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Sample records for reported depressed mood

  1. Social support and depressed mood in isolated and confined environments

    Palinkas, Lawrence A.; Johnson, Jeffrey C.; Boster, James S.

    2004-05-01

    The influence of isolation and confinement on social support and depressed mood was examined in a study of 235 men and women who spent a year at McMurdo Station in Antarctica, and a study of 77 men and women who spent a year at the Amundson-Scott South Pole Station. Although availability of support remained unchanged, there was a significant decrease in reported satisfaction with support obtained, as well as a significant increase in depressed mood. Satisfaction with support was inversely associated with depressed mood at the beginning and end of isolation and confinement. At the end of winter, this association varied by source of support. High levels of tension-anxiety, depression and anger preceded an increase in advice seeking, but high levels of advice seeking also preceded an increase in tension-anxiety and depression. Results suggest a significant erosion of social support under conditions of prolonged isolation and confinement, leading to an increase in depressed mood.

  2. Risk and Protective Factors Associated with Trajectories of Depressed Mood from Adolescence to Early Adulthood

    Costello, Darce M.; Swendsen, Joel; Rose, Jennifer S.; Dierker, Lisa C.

    2008-01-01

    This study used semi-parametric group-based modeling to explore unconditional and conditional trajectories of self-reported depressed mood from ages 12 to 25 years. Drawing on data from the National Longitudinal Study of Adolescent Health (N = 11,559), 4 distinct trajectories were identified: no depressed mood, stable low depressed mood, early…

  3. Depressed Mood and Maternal Report of Child Behavior Problems: Another Look at the Depression-Distortion Hypothesis.

    Gartstein, Maria A; Bridgett, David J; Dishion, Thomas J; Kaufman, Noah K

    2009-03-01

    Caregiver depression has been described as leading to overreport of child behavior problems. This study examines this "depression-distortion" hypothesis in terms of high-risk families of young adolescents. Questionnaire and diagnostic interview data were collected from mothers, teachers, and fathers, and self-report information was obtained from youth between ages 10 and 14 years. First, convergent and discriminant validity were demonstrated for internalizing and externalizing multiagent constructs. Second, the depression-distortion hypothesis was examined, revealing a modest effect of maternal depression, leading to the inflation of reported son externalizing and daughter internalizing problems. The data suggest the need to consider multiple influences on parental perceptions of child behavior and psychopathology in research and clinical settings. PMID:20161323

  4. Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer

    Prabhavalkar, Kedar S.; Poovanpallil, Nimmy B.; Bhatt, Lokesh K.

    2015-01-01

    The efficacy of lamotrigine in the treatment of focal epilepsies have already been reported in several case reports and open studies, which is thought to act by inhibiting glutamate release through voltage-sensitive sodium channels blockade and neuronal membrane stabilization. However, recent findings have also illustrated the importance of lamotrigine in alleviating the depressive symptoms of bipolar disorder, without causing mood destabilization or precipitating mania. Currently, no mood st...

  5. Examination of Adolescents' Negative Thoughts, Depressive Mood and Family Environment.

    Aydin, Betul; Oztutuncu, Filiz

    2001-01-01

    Study focused on the relationship among adolescents' negative thoughts, depressive mood and family environment. Family cohesion was found to be related to the degree of negative thoughts and depressive mood, while perceived control within the family was not. (BF)

  6. College Students’ Perceptions of Depressed Mood: Exploring Accuracy and Associations

    Geisner, Irene M.; Kirk, Jennifer L.; Mittmann, Angela J.; Kilmer, Jason R.; LARIMER, MARY E.

    2015-01-01

    College is a time of high risk for depressed mood. Theories about depression (i.e. Cognitive Theory and Depressive Realism theory) are well researched, but suggest different venues of understanding the cognitive underpinnings of mood. In addition, much research is available about normative perceptions around substance use and how those perceptions relate to behaviors. However, there are no studies examining normative perceptions around depressed mood nor how these perceptions may relate to st...

  7. Ruminative thought style and depressed mood.

    Brinker, Jay K; Dozois, David J A

    2009-01-01

    Recent research has suggested that the measure most commonly used to assess rumination, the Response Style Questionnaire (RSQ; L. D. Butler & S. Nolen-Hoeksema, 1994), may be heavily biased by depressive symptoms, thereby restricting the scope of research exploring this construct. This article offers a broader conceptualization of rumination, which includes positive, negative, and neutral thoughts as well as past and future-oriented thoughts. The first two studies describe the development and evaluation of the Ruminative Thought Style Questionnaire (RTS), a psychometrically sound measure of the general tendency to ruminate. Further, the scale is comprised of a single factor and shows high internal consistency, suggesting that rumination does encompasses the factors mentioned. The final study involved a longitudinal diary investigation of rumination and mood over time. Results suggest that the RTS assesses a related, but separate, construct than does the RSQ. RTS scores predicted future depressed mood beyond the variance accounted for by initial depressed mood whereas RSQ scores did not. The implications of these results and directions for future research are discussed. PMID:19048597

  8. Mood, self-set goals and examination performance: the moderating effect of depressed mood

    Lane, Andrew M; Whyte, Gregory P; Peter C. Terry; Alan M Nevill

    2005-01-01

    The purpose of the present study was to investigate relationships between mood, performance goals, and examination performance. We tested the notion that feelings of depressed mood are central to the overall mood response and influence the functional impact of anger and tension on performance (see Lane & Terry, 2000). Fifty undergraduate students completed a measure of anger, confusion, depression, fatigue, tension and vigour approximately 10 min before a practical physiology examination. Par...

  9. A momentary biomarker for depressive mood.

    Kim, Jinhyuk; Nakamura, Toru; Yamamoto, Yoshiharu

    2016-12-01

    Many biomarkers from genetic, neuroimaging, and biological/biochemical measures have been recently developed in order to make a shift toward the objective evaluation of psychiatric disorders. However, they have so far been less successful in capturing dynamical changes or transitions in pathological states, such as those occurring during the course of clinical treatments or pathogenic processes of disorders. A momentary biomarker is now required for objective monitoring of such dynamical changes. The development of ecological momentary assessment (EMA) allows the assessment of dynamical aspects of diurnal/daily clinical conditions and subjective symptoms. Furthermore, a variety of validation studies on momentary symptoms assessed by EMA using behavioral/physiological/biochemical measures have demonstrated the possibility of evaluating momentary symptoms from such external objective measures. In this review, we introduce physical activity as a candidate biobehavioral biomarker for psychiatric disorders. We also mention its potential as a momentary biomarker for depressive mood. Finally, we address the continuous monitoring of the pathogenic processes and pathological states of depressive disorders based on physical activity, as well as its application in pharmacological animal studies. PMID:26979449

  10. Storm in My Brain: Kids and Mood Disorders (Bipolar Disorder and Depression)

    ... Storm in my Brain Kids and Mood Disorders (Bipolar Disorder and Depression) What is a mood disorder? Everyone ... with high energy. It is one part of bipolar disorder, also called manic depression. In bipolar disorder, moods ...

  11. Depressed Mood and Maternal Report of Child Behavior Problems: Another Look at the Depression–Distortion Hypothesis

    Gartstein, Maria A.; Bridgett, David J.; Dishion, Thomas J.; Kaufman, Noah K.

    2009-01-01

    Caregiver depression has been described as leading to overreport of child behavior problems. This study examines this “depression–distortion” hypothesis in terms of high-risk families of young adolescents. Questionnaire and diagnostic interview data were collected from mothers, teachers, and fathers, and self-report information was obtained from youth between ages 10 and 14 years. First, convergent and discriminant validity were demonstrated for internalizing and externalizing multiagent constructs. Second, the depression–distortion hypothesis was examined, revealing a modest effect of maternal depression, leading to the inflation of reported son externalizing and daughter internalizing problems. The data suggest the need to consider multiple influences on parental perceptions of child behavior and psychopathology in research and clinical settings. PMID:20161323

  12. Depressed mood, anxiety, and the use of labor analgesia.

    Pettersson, Fatimah Dabo; Hellgren, Charlotte; Nyberg, Fred; Ćkerud, Helena; Sundström-Poromaa, Inger

    2016-02-01

    Relatively little is known about mental health and labor pain. The aim of this study was to assess if self-rated antenatal depressed mood and anxiety are associated with pain-related behaviors and self-reported labor pain. We also wanted to replicate our previous finding of altered labor pain behavior in carriers of a specific guanosine triphosphate cyclohydrolase 1 gene (GCH1) haplotype. Ninety-nine women in gestational weeks 37 to 40 filled out questionnaires on depression and anxiety symptoms and later rated their labor pain by use of visual analog scales. Each subject was also genotyped for GCH1. Following adjustment for relevant confounders, women who arrived early to the delivery unit (cervical dilation 5 cm). Women with increased Spielberger State-Trait Anxiety Inventory (STAI-T) scores reported higher self-rated pain prior to labor analgesia, p?pain-protective haplotype and cervical dilation was found, but a previously demonstrated association with increased use of second-line analgesia was confirmed. Depressed mood during pregnancy is associated with early arrival to the delivery department, whereas antenatal anxiety is associated with increased self-rated pain prior to labor analgesia. PMID:26392364

  13. Frequent assessment of negative symptoms does not induce depressed mood

    Joan E. Broderick; Vikingstad, Gregory

    2008-01-01

    Use of real-time data collection is rapidly expanding in the medical sciences and questions have been raised as to whether frequent ratings of disease symptoms could evoke depressed mood. This study investigated the effect of an intensive momentary assessment protocol on depressed mood. Community rheumatology patients (N=105) were recruited to participate in a 30-day momentary assessment protocol of pain and fatigue. Patients were randomly signaled and completed approximately 6 ratings per da...

  14. Depressed mood in pregnancy: Prevalence and correlates in two Cape Town peri-urban settlements

    le Roux Ingrid; Stewart Jacqueline; Comulada W Scott; Greco Erin; Tomlinson Mark; Hartley Mary; Mbewu Nokwanele; Rotheram-Borus Mary Jane

    2011-01-01

    Abstract Background The disability associated with depression and its impact on maternal and child health has important implications for public health policy. While the prevalence of postnatal depression is high, there are no prevalence data on antenatal depression in South Africa. The purpose of this study was to determine the prevalence and correlates of depressed mood in pregnancy in Cape Town peri-urban settlements. Methods This study reports on baseline data collected from the Philani Me...

  15. Early Adolescent Depressive Mood: Direct and Indirect Effects of Attributional Styles and Coping

    Chan, Siu Mui

    2012-01-01

    The present study used a cross-sectional survey design to examine how adolescent depressive mood was related to attributional styles and coping strategies with a sample of 326 youths (aged 8-14 years). With the cutting point adopted in the West, 20.9% of the current sample reported depressive symptoms. Regression analysis results show that, with


  16. Early Adolescent Depressive Mood: Direct and Indirect Effects of Attributional Styles and Coping

    Chan, Siu Mui

    2012-01-01

    The present study used a cross-sectional survey design to examine how adolescent depressive mood was related to attributional styles and coping strategies with a sample of 326 youths (aged 8-14 years). With the cutting point adopted in the West, 20.9% of the current sample reported depressive symptoms. Regression analysis results show that, with…

  17. Adolescents' Perceptions of Family Connectedness, Intrinsic Religiosity, and Depressed Mood

    Houltberg, Benjamin J.; Henry, Carolyn S.; Merten, Michael J.; Robinson, Linda C.

    2011-01-01

    Using a sample of 248 ninth and tenth grade students at public high schools, we examined adolescents' perceptions of family connectedness, intrinsic religiosity, and adolescents' gender in relation to depressed mood and whether intrinsic religiosity and gender moderated the association of aspects of family connectedness to adolescent depressed…

  18. Temporal Patterns of Anxious and Depressed Mood in Generalized Anxiety Disorder: A Daily Diary Study

    Starr, Lisa R.; Davila, Joanne

    2011-01-01

    Research suggests that anxiety disorders tend to temporally precede depressive disorders, a finding potentially relevant to understanding comorbidity. The current study used diary methods to determine whether daily anxious mood also temporally precedes daily depressed mood. 55 participants with generalized anxiety disorder (GAD) and history of depressive symptoms completed a 21-day daily diary tracking anxious and depressed mood. Daily anxious and depressed moods were concurrently associated....

  19. The effects of cognitive-behavioural therapy on mood-related ruminative response style in depressed adolescents

    Goodyer Ian M; Wilkinson Paul O

    2008-01-01

    Abstract Background A mood-related ruminative response style increases the risk of onset and persistence of depression. This preliminary study investigated whether, in depressed adolescents, cognitive-behaviour therapy reduces mood-related ruminative response style. Whether specific factors within the rumination scale were differentially affected by CBT is also reported. Methods 26 depressed adolescents were randomised to receiving serotonin-specific reuptake inhibitor antidepressants (SSRI) ...

  20. Familiality of mood repair responses among youth with and without histories of depression.

    Bylsma, Lauren M; Yaroslavsky, Ilya; Rottenberg, Jonathan; Kiss, EnikƑ; Kapornai, Krisztina; Halas, Kitti; Dochnal, Roberta; Lefkovics, Eszter; Baji, Ildikό; Vetrό, Ágnes; Kovacs, Maria

    2016-06-01

    Affect regulation skills develop in the context of the family environment, wherein youths are influenced by their parents', and possibly their siblings', regulatory responses and styles. Regulatory responses to sadness (mood repair) that exacerbate or prolong dysphoria (maladaptive mood repair) may represent one way in which depression is transmitted within families. We examined self-reported adaptive and maladaptive mood repair responses across cognitive, social and behavioural domains in Hungarian 11- to 19-year-old youth and their parents. Offspring included 214 probands with a history of childhood-onset depressive disorder, 200 never depressed siblings and 161 control peers. Probands reported the most problematic mood repair responses, with siblings reporting more modest differences from controls. Mood repair responses of parents and their offspring, as well as within sib-pairs, were related, although results differed as a function of the regulatory response domain. Results demonstrate familiality of maladaptive and adaptive mood repair responses in multiple samples. These familial associations suggest that relationships with parents and siblings within families may impact the development of affect regulation in youth. PMID:25849259

  1. Does Negative Mood Influence Self-Report Assessment of Individual and Relational Measures? An Experimental Analysis

    Heene, Els; De Raedt, Rudi; Buysse, Ann; Van Oost, Paulette

    2007-01-01

    The present study was designed to test the influence of negative mood on the self-report of individual and relational correlates of depression and marital distress. The authors applied a combined experimental mood induction procedure, based on music, autobiographical recall, and environmental manipulation. Results showed that the mood manipulation…

  2. Does Negative Mood Influence Self-Report Assessment of Individual and Relational Measures? An Experimental Analysis

    Heene, Els; De Raedt, Rudi; Buysse, Ann; Van Oost, Paulette

    2007-01-01

    The present study was designed to test the influence of negative mood on the self-report of individual and relational correlates of depression and marital distress. The authors applied a combined experimental mood induction procedure, based on music, autobiographical recall, and environmental manipulation. Results showed that the mood manipulation


  3. Mood congruent memory bias of individuals with depressed mood and anxiety

    Lange, Gregor; CARR, ALAN

    2001-01-01

    Fifteen individuals with clinically significant levels of both depressed mood and anxiety were compared with 20 demographically similar controls on implicit and explicit memory tests for recall of negative, physically threatening, socially threatening, positive and neutral word stimuli. Compared with the control group, the depressed and anxious group remembered more negative and socially threatening words and fewer positive words in both the implicit and explicit memory conditions...

  4. The effects of Chinese five-element music therapy on nursing students with depressed mood.

    Chen, Chen-Jung; Sung, Huei-Chuan; Lee, Ming-Shinn; Chang, Ching-Yuan

    2015-04-01

    This study aimed to evaluate the effects of Chinese five-element music therapy on nursing students with depressed mood. We randomly assigned 71 nursing students from Taiwan with depressed mood to the music and control groups. The music group (n = 31) received Chinese five-element music therapy, whereas the participants in the control group (n = 40) maintained their routine lifestyles with no music therapy. All of the participants were assessed using the Depression Mood Self-Report Inventory for Adolescence, and their salivary cortisol levels were measured. The study found that there was a significant reduction in depression between the pre- and posttherapy test scores and in salivary cortisol levels over time in the music group. After receiving the music therapy, the nursing students' depression levels were significantly reduced (P = 0.038) compared with the control group (P music therapy has the potential to reduce the level of depression in nursing students with depressed mood. PMID:24593291

  5. Social Context in School: Its Relation to Adolescents' Depressive Mood

    Boulard, Aurore; Quertemont, Etienne; Gauthier, Jean-Marie; Born, Michel

    2012-01-01

    This study examined the impact of various school-related factors on adolescents' depressive mood, including prosocial behavior, verbal aggression, and relationships with teachers. The data used in this study were collected in the context of a larger survey on victimization in secondary schools from the French Community of Belgium. Participants…

  6. Cyberbullying Victimisation in Adolescence: Relationships with Loneliness and Depressive Mood

    Olenik-Shemesh, Dorit; Heiman, Tali; Eden, Sigal

    2012-01-01

    Cyberbullying is deliberate, aggressive activity carried out through digital means. Cybervictimisation in adolescence may be related to negative psychosocial variables such as loneliness and depressive mood. The purpose of the present study, the first of its kind in Israel, was to examine the association between adolescent cybervictimisation and…

  7. Depressed mood in pregnancy: Prevalence and correlates in two Cape Town peri-urban settlements

    le Roux Ingrid

    2011-05-01

    Full Text Available Abstract Background The disability associated with depression and its impact on maternal and child health has important implications for public health policy. While the prevalence of postnatal depression is high, there are no prevalence data on antenatal depression in South Africa. The purpose of this study was to determine the prevalence and correlates of depressed mood in pregnancy in Cape Town peri-urban settlements. Methods This study reports on baseline data collected from the Philani Mentor Mothers Project (PMMP, a community-based, cluster-randomized controlled trial on the outskirts of Cape Town, South Africa. The PMMP aims to evaluate the effectiveness of a home-based intervention for preventing and managing illnesses related to HIV, TB, alcohol use and malnutrition in pregnant mothers and their infants. Participants were 1062 pregnant women from Khayelitsha and Mfuleni, Cape Town. Measures included the Edinburgh Postnatal Depression Scale (EPDS, the Derived AUDIT-C, indices for social support with regards to partner and parents, and questions concerning socio-demographics, intimate partner violence, and the current pregnancy. Data were analysed using bivariate analyses followed by logistic regression. Results Depressed mood in pregnancy was reported by 39% of mothers. The strongest predictors of depressed mood were lack of partner support, intimate partner violence, having a household income below R2000 per month, and younger age. Conclusions The high prevalence of depressed mood in pregnancy necessitates early screening and intervention in primary health care and antenatal settings for depression. The effectiveness and scalability of community-based interventions for maternal depression must be developed for pregnant women in peri-urban settlements. Trial registration ClinicalTrials.gov: NCT00972699.

  8. Adolescent Perceptions of Parental Behaviors, Adolescent Self-Esteem, and Adolescent Depressed Mood

    Plunkett, Scott W.; Henry, Carolyn S.; Robinson, Linda C.; Behnke, Andrew; Falcon, Pedro C., III

    2007-01-01

    Using symbolic interaction, we developed a research model that proposed adolescent perceptions of parental support and psychological control would be related to adolescent depressed mood directly and indirectly through self-esteem. We tested the model using self-report questionnaire data from 161 adolescents living with both of their biological…

  9. Adolescent Perceptions of Parental Behaviors, Adolescent Self-Esteem, and Adolescent Depressed Mood

    Plunkett, Scott W.; Henry, Carolyn S.; Robinson, Linda C.; Behnke, Andrew; Falcon, Pedro C., III

    2007-01-01

    Using symbolic interaction, we developed a research model that proposed adolescent perceptions of parental support and psychological control would be related to adolescent depressed mood directly and indirectly through self-esteem. We tested the model using self-report questionnaire data from 161 adolescents living with both of their biological


  10. "I felt sad and did not enjoy life": Cultural context and the associations between anhedonia, depressed mood, and momentary emotions.

    Chentsova-Dutton, Yulia E; Choi, Eunsoo; Ryder, Andrew G; Reyes, Jenny

    2015-10-01

    The meanings of "anhedonia" and "depressed mood," the cardinal emotional symptoms of major depression, may be shaped by cultural norms regarding pleasure and sadness. Thirty-two European Americans, 26 Hispanic Americans, 33 Asian Americans, and 20 Russian Americans provided reports of (a) depressive symptoms, (b) momentary emotions and pleasure, and (c) global subjective well-being. Momentary reports were collected over 10 days using handheld personal digital assistants. Reports of anhedonia were associated with heightened levels of momentary low arousal negative emotions (e.g., sadness), whereas reports of depressed mood were associated with dampened levels of momentary positive emotions (e.g., happiness). Symptoms of anhedonia and depressed mood interacted in their associations with momentary pleasure. In addition, the associations of anhedonia and depressed mood with positive emotions and life satisfaction differed across cultural groups. Specifically, these symptoms were associated with dampened positive emotions in the Asian American group only. Additionally, anhedonia was associated with dampened global life satisfaction in the European American group only. These results suggest that reports of anhedonia and depressed mood cannot be interpreted at face value as specific and culture-free indicators of emotional deficits. Instead, they appear to signal changes in the balance of positive and negative emotions, with the exact nature of these signals shaped at least in part by cultural context. This conclusion has important consequences for the clinical interpretation of depressive symptoms in multicultural societies. PMID:25603917

  11. Risk Factors Linking Maternal Depressed Mood to Growth in Adolescent Substance Use

    Cortes, Rebecca C.; Fleming, Charles B.; Mason, W. Alex; Catalano, Richard F.

    2009-01-01

    Maternal depression has been implicated in the development of adolescent substance use. Conceptualizing depression as a continuum, the aims of this study are to (a) understand the relationship between maternal depressed mood and risk factors associated with adolescent substance use; (b) understand the relationship between maternal depressed mood…

  12. Gender Differences in Responses to Depressed Mood in a College Sample.

    Butler, Lisa D.; Nolen-Hoeksema, Susan

    1994-01-01

    Two studies involving 151 male and 103 female college students tested the hypothesis that women are more likely than men to focus on themselves and their moods when in a depressed mood, leading to longer periods of depressed mood. Results support the hypothesis. (SLD)

  13. Mood self-assessment in bipolar disorder: a comparison between patients in mania, depression, and euthymia

    Rafael de Assis da Silva

    2013-01-01

    Full Text Available BACKGROUND: Some studies indicate that mood self-assessment is more severely impaired in patients with bipolar disorder in a manic episode than in depression. OBJECTIVES: To investigate variations in mood self-assessment in relation to current affective state in a group of individuals with bipolar disorder. METHODS: A total of 165 patients with a diagnosis of bipolar disorder type I or type II had their affective state assessed using the Clinical Global Impressions Scale for use in bipolar illness (CGI-BP, the Positive and Negative Syndrome Scale (PANSS, and the Global Assessment of Functioning (GAF. In addition, participants completed a self-report visual analog mood scale (VAMS. Patients were divided into three groups (euthymia, mania, and depression and compared with regard to VAMS results. RESULTS: Manic patients rated their mood similarly to patients in euthymia in 14 out of 16 items in the VAMS. By contrast, depressed patients rated only two items similarly to euthymic patients. CONCLUSION: Patients with bipolar disorder in mania, but not those in depression, poorly evaluate their affective state, reinforcing the occurrence of insight impairment in the manic syndrome.

  14. Interactive Effect of Child Maltreatment and Substance Use on Depressed Mood Among Adolescents Presenting to Community-Based Substance Use Treatment.

    Gomez, Judelysse; Becker, Sara; O'Brien, Kimberly; Spirito, Anthony

    2015-10-01

    Adolescents referred to community behavioral health centers (CBHC) for substance use (SU) problems report high rates of child maltreatment. Although SU and maltreatment are independent risk factors for adolescent depression, few studies have examined their interactive effects. This study examined the interactive effects of SU (alcohol and marijuana) and exposure to different types of trauma on depressed mood among 74 adolescents referred to a CBHC for SU. Hierarchical regressions controlling for sex and common adolescent comorbidities showed that sexual abuse had a stronger relationship with depressed mood than other types of maltreatment. Although SU was not independently related to depressed mood, consistent with the self-medication hypothesis, increased SU was associated with lower levels of depressed mood among adolescents with greater exposure to sexual abuse. Results suggest that teens presenting to CBHCs for SU should be assessed for multiple forms of maltreatment and for depressed mood. PMID:26017474

  15. The effects of cognitive-behavioural therapy on mood-related ruminative response style in depressed adolescents

    Goodyer Ian M

    2008-01-01

    Full Text Available Abstract Background A mood-related ruminative response style increases the risk of onset and persistence of depression. This preliminary study investigated whether, in depressed adolescents, cognitive-behaviour therapy reduces mood-related ruminative response style. Whether specific factors within the rumination scale were differentially affected by CBT is also reported. Methods 26 depressed adolescents were randomised to receiving serotonin-specific reuptake inhibitor antidepressants (SSRI plus psychosocial treatment as usual or SSRI and psychosocial treatment as usual plus CBT. Ruminative response style and depressive symptoms were measured at baseline and after 30 weeks of treatment, with the Responses to Depression Questionnaire and Mood and Feelings Questionnaire. Results There were significantly greater reductions in ruminations in the CBT group compared to the non-CBT group (p = .002. There was no significant difference in the reduction in self-reported depressive symptoms between the groups. Rumination was reduced to levels of never-depressed controls in adolescents who had recovered from depression and received CBT. There were greater falls in the CBT group in the more pathological 'brooding' factor of rumination. Conclusion These findings suggest that adding CBT to SSRI medication in the presence of active clinical care causes a greater reduction in mood-related ruminative response style in depressed adolescents. This may reduce the risk of future relapse. Trial registration Current Controlled Trials ISRCNT83809224.

  16. Does outdoor work during the winter season protect against depression and mood difficulties?

    Hahn, Ina H; Grynderup, Matias Brþdsgaard; Dalsgaard, Sofie B; Thomsen, Jane F; Hansen, Åse Marie; Kérgaard, Anette; Kérlev, Linda; Mors, Ole; Rugulies, Reiner; Mikkelsen, Sigurd; Bonde, Jens Peter; Kolstad, Henrik

    2011-01-01

    At temperate latitudes, 1-5% of the population suffer from winter depression; during winter, mood difficulties tend to increase but may be alleviated by bright light therapy. Unlike indoor workers, outdoor workers are exposed to therapeutic levels of sunlight during winter. We hypothesized that...... outdoor work may protect against mood difficulties and depression....

  17. Inhibitory Control Mediates the Relationship between Depressed Mood and Overgeneral Memory Recall in Children

    Raes, Filip; Verstraeten, Katrien; Bijttebier, Patricia; Vasey, Michael W.; Dalgleish, Tim

    2010-01-01

    It has been well established that depressed mood is related to overgeneral memory recall (OGM), which refers to a relative difficulty in retrieving specific information from one's autobiographical memory (AM). The present study examined whether OGM is also related to depressed mood in children and whether lack of inhibitory control mediates this


  18. Inhibitory Control Mediates the Relationship between Depressed Mood and Overgeneral Memory Recall in Children

    Raes, Filip; Verstraeten, Katrien; Bijttebier, Patricia; Vasey, Michael W.; Dalgleish, Tim

    2010-01-01

    It has been well established that depressed mood is related to overgeneral memory recall (OGM), which refers to a relative difficulty in retrieving specific information from one's autobiographical memory (AM). The present study examined whether OGM is also related to depressed mood in children and whether lack of inhibitory control mediates this…

  19. Heterogeneity in Antisocial Behaviours and Comorbidity with Depressed Mood: A Behavioural Genetic Approach

    Rowe, Richard; Rijsdijk, Fruhling V.; Maughan, Barbara; Eley, Thalia C.; Hosang, Georgina M.

    2008-01-01

    Background: Antisocial behaviour is often comorbid with depressed mood but is itself a collection of heterogeneous behaviours. Using a genetically informative design, we examine heterogeneity in antisocial behaviour and overlaps between different forms of antisocial behaviour with depressed mood. Methods: Data were drawn from the G1219 large-scale


  20. Depression Moderates Smoking Behavior in Response to a Sad Mood Induction

    Fucito, Lisa M; Juliano, Laura M.

    2009-01-01

    Previous laboratory research suggests that stress and anxiety increase smoking motivation and are attenuated by smoking. There is little experimental data, however, on the relationship between depressed or sad mood and smoking. This study investigated if induced sadness would have a differential effect on smoking behavior compared to a neutral mood state. Baseline depression scores were examined as a potential moderator of this relationship. Mood changes were also tested as a potential mediat...

  1. Trajectories of alcohol use and consequences in college women with and without depressed mood.

    Kenney, Shannon; Abar, Caitlin C; O'Brien, Kimberly; Clark, Gabrielle; LaBrie, Joseph W

    2016-02-01

    College students with depressed mood face heightened risk for experiencing drinking-related negative consequences. However, few studies have examined prospective patterns of alcohol consequences among depressed students. In the present investigation, we assessed how first-year college women's trajectories of heavy episodic drinking (HED) and alcohol consequences differed as a function of depressed mood at college entry. Participants were 233 heavy drinking incoming first-year college females (61% White) at a mid-sized West Coast University. Participants completed an online baseline survey, attended a single brief group intervention session, and completed 1- and 6-month post-intervention follow-up surveys. Depressed mood, alcohol consumption, and alcohol consequences were assessed at each time point. We employed latent growth curve analyses. Females with depressed mood, versus without depressed mood, experienced greater levels of alcohol consequences overall, particularly during transitions to college. However, contrary to hypotheses, participants with depressed mood (vs. without) exhibited significantly steeper declining trends in consequences, controlling for treatment condition, age, race, and ethnicity, and despite stable drinking levels, depressed mood, and use of protective behaviors over time. Potential explanations and suggestions for future research are discussed. PMID:26426743

  2. Cognitive reactivity to sad mood: The importance of the first depressive episode

    Marić Zorica

    2010-01-01

    Full Text Available Cognitive reactivity to sad mood refers to the degree to which a mild dysphoric state reactivates negative thinking patterns. In this research, the contribution of the history of depression, the length of the current depressive episode and the intensity of the depressive symptoms were assessed in explaining the cognitive reactivity to sad mood measured with the Leiden Index of Depression Sensitivity (LEIDS. The sample consisted of 123 depressed outpatients. The results of principal components analysis suggested a three-factor solution of the LEIDS. The intensity of depressive symptoms, the history of depression and the length of the current depressive episode were all significant in explaining cognitive reactivity to sad mood. We have also found out a significant effect of interaction of the history of depression and the length of the current depressive episode, which demonstrated that a prolonged depression does not induce a stronger cognitive reactivity to sad mood during the relapse of a depressive episode, while during the first depressive episode a longer duration of depression does induce a stronger cognitive reactivity. Such a result demonstrates that the length of the first depressive episode, regardless of its intensity, is crucially important for the formation of cognitive reactivity.

  3. A cognitive neuroscience hypothesis of mood and depression

    Bar, Moshe

    2009-01-01

    Although mood has a direct impact on mental and physical health, our understanding of the mechanisms underlying mood regulation is limited. I propose here that there is a direct, reciprocal relation between the cortical activation of associations and mood regulation, whereby positive mood promotes associative processing, and associative processing promotes positive mood. This relation might stem from an evolutionary pressure for learning and predicting. Along these lines, one can think of moo...

  4. Cortisol response to acute stress in asthma: Moderation by depressive mood.

    Trueba, Ana F; Simon, Erica; Auchus, Richard J; Ritz, Thomas

    2016-05-15

    Both individuals with asthma and depression show signs of a dysregulated hypothalamus-pituitary-adrenal axis. However, little is known about the cortisol response to stress in the context of co-occurring asthma and depressive mood. Thirty-nine individuals with asthma and 41 healthy controls underwent a combined speech and mental arithmetic stressor. During the course of the laboratory session, salivary cortisol was collected 5 times, with 1 sample at 0min before the stressor and 4 samples at 0, 15, 30 and 45min after the stressor. Depressive mood in the past week was assessed with the Hospital Anxiety and Depression Scale at the beginning of the session. Depressive symptoms moderated cortisol response to the acute stressor, but only among asthmatic patients. Higher depressive mood was associated with a significant increase in cortisol, whereas low depressive mood was associated with no cortisol response. In healthy participants, depressive mood had no substantial effect on cortisol response to the stressor. These findings suggest that depressive mood and chronic inflammatory diseases such as asthma can interact to augment cortisol response to stress. PMID:26965527

  5. Autobiographical Memory in Adults with Autism Spectrum Disorder: The role of Depressed Mood, Rumination, Working Memory and Theory of Mind

    Crane, Laura; Goddard, Lorna; Pring, Linda

    2013-01-01

    Autobiographical memory difficulties have been widely reported in adults with autism spectrum disorder (ASD). The aim of the current study was to explore the potential correlates of autobiographical memory performance (including depressed mood, rumination, working memory and theory of mind) in adults with ASD, relative to a group of typical adults


  6. Autobiographical Memory in Adults with Autism Spectrum Disorder: The role of Depressed Mood, Rumination, Working Memory and Theory of Mind

    Crane, Laura; Goddard, Lorna; Pring, Linda

    2013-01-01

    Autobiographical memory difficulties have been widely reported in adults with autism spectrum disorder (ASD). The aim of the current study was to explore the potential correlates of autobiographical memory performance (including depressed mood, rumination, working memory and theory of mind) in adults with ASD, relative to a group of typical adults…

  7. Comparing the effectiveness of mood stabilizers and antidepressants for bipolar depression treatment: a retrospective chart review

    Nickholas Craddock

    2010-01-01

    Full Text Available Objective: The purpose of this study was to evaluate the effect of antidepressants on recovery in bipolar depression. Method: The most recent depressive episode of patients with DSM-IV Bipolar Disorder, recruited from a specialized mood disorder outpatient unit in Turkey, were evaluated retrospectively. Thirty-four patients, only received mood stabilizer titration or did not change their current treatment regimens and thirty patients, treated with an antidepressant agent were compared on rates of recurrence and time to remission. Results: One third of patients in each group were taking at least one mood stabilizer during their depressive episodes. Mood stabilizer levels were similar in each group and were within therapeutic limits. There were no significant differences between groups on rates of recurrence or time to remission. Conclusions: In this preliminary retrospective study, patients with bipolar depression who were treated with antidepressants did not have a better outcome than patients who received no antidepressants.

  8. Mood Symptoms, Cognition, and Everyday Functioning: in Major Depression, Bipolar Disorder, and Schizophrenia

    Harvey, Philip D.

    2011-01-01

    People with depression, bipolar disorder, and schizophrenia manifest considerable cognitive deficits and impairments in everyday functional outcomes. The severity of current mood symptoms is associated with the severity of cognitive deficits in people with unipolar and bipolar disorder, but impairments are clearly still present in cases with minimal current mood symptoms. In people with schizophrenia, depression is less strongly associated with cognitive deficits on a cross-sectional basis, a...

  9. Feeling and Time: The Phenomenology of Mood Disorders, Depressive Realism, and Existential Psychotherapy

    Ghaemi, S. Nassir

    2006-01-01

    Phenomenological research suggests that pure manic and depressive states are less common than mixtures of the two and that the two poles of mood are characterized by opposite ways of experiencing time. In mania, the subjective experience of time is sped up and in depression it is slowed down, perhaps reflecting differences in circadian pathophysiology. The two classic mood states are also quite different in their effect on subjective awareness: manic patients lack insight into their excitatio...

  10. Mood and the market: can press reports of investors' mood predict stock prices?

    Cohen-Charash, Yochi; Scherbaum, Charles A; Kammeyer-Mueller, John D; Staw, Barry M

    2013-01-01

    We examined whether press reports on the collective mood of investors can predict changes in stock prices. We collected data on the use of emotion words in newspaper reports on traders' affect, coded these emotion words according to their location on an affective circumplex in terms of pleasantness and activation level, and created indices of collective mood for each trading day. Then, by using time series analyses, we examined whether these mood indices, depicting investors' emotion on a given trading day, could predict the next day's opening price of the stock market. The strongest findings showed that activated pleasant mood predicted increases in NASDAQ prices, while activated unpleasant mood predicted decreases in NASDAQ prices. We conclude that both valence and activation levels of collective mood are important in predicting trend continuation in stock prices. PMID:24015202

  11. Magnetic seizure therapy improves mood in refractory major depression.

    Kosel, Markus; Frick, Caroline; Lisanby, Sarah H; Fisch, Hans-Ulrich; Schlaepfer, Thomas E

    2003-11-01

    This report describes the successful treatment of a patient suffering from an episode of drug-resistant major depression using magnetic seizure therapy (MST). The patient suffered from recurrent major depression since adolescence. MST is a novel brain stimulation method using transcranial magnetic stimulation at convulsive parameters in order to induce therapeutic seizures under general anesthesia in the same setting used for electroconvulsive therapy (ECT). The first use of therapeutic magnetic seizure induction in a psychiatric patient took place at the University Hospital in Bern, Switzerland, in May 2000. Results of a recent randomized, within-subject, double-masked trial comparing ECT and MST in 10 patients indicate that MST appears to have less subjective and objective side effects, is associated with faster recovery of orientation, and is superior to ECT on measures of attention, retrograde amnesia, and category fluency. ECT has an unparalleled and well-documented efficacy in severe depression but is associated with cognitive side effects. MST is currently under study in several centers with respect to its antidepressant efficacy. We report here on the treatment of a patient with refractory major depression (DSM IV-R), who underwent a series of 12 sessions of MST in an inpatient setting. Baseline Hamilton Depression Rating Scale (HRSD-21) of 33 and Beck Depression Inventory (BDI) of 40 decreased to 6 and 11 respectively, 1 week after completion of the MST trial. Measures of cognitive functions support the hypothesis that MST is associated with a less severe profile of cognitive side effects. [(99m)Tc]-HMPAO SPECT studies (baseline and 4 days after the completion of the MST trial) point to a raise of blood flow at baseline in the left fronto-parietal region and the brainstem. Our preliminary data support the prospect of antidepressant efficacy of MST and point to a benign cognitive side-effect profile in a patient suffering from severe treatment-resistant major depression. PMID:12942146

  12. Sensorimotor modulation of mood and depression: In search of an optimal mode of stimulation

    RESIT CANBEYLI

    2013-07-01

    Full Text Available Depression involves a dysfunction in an affective fronto-limbic circuitry including the prefrontal cortices, several limbic structures including the cingulate cortex, the amygdala and the hippocampus as well as the basal ganglia. A major emphasis of research on the etiology and treatment of mood disorders has been to assess the impact of centrally generated (top-down processes impacting the affective fronto-limbic circuitry. The present review shows that peripheral (bottom-up unipolar stimulation via the visual and the auditory modalities as well as by physical exercise modulates mood and depressive symptoms in humans and animals and activates the same central affective neurocircuitry involved in depression. It is proposed that the amygdala serves as a gateway by articulating the mood regulatory sensorimotor stimulation with the central affective circuitry by emotionally labeling and mediating the storage of such emotional events in long-term memory. Since both amelioration and aggravation of mood is shown to be possible by unipolar stimulation, the review suggests that a psychophysical assessment of mood modulation by multi-modal stimulation may uncover mood ameliorative synergisms and serve as adjunctive treatment for depression. Thus, the integrative review not only emphasizes the relevance of investigating the optimal levels of mood regulatory sensorimotor stimulation, but also provides a conceptual springboard for related future research.

  13. Mood Disorders

    ... say they're in a bad mood. A mood disorder is different. It affects a person's everyday emotional ... in ten people aged 18 and older have mood disorders. These include depression and bipolar disorder (also called ...

  14. Screening for Depressive Disorders Using the Mood and Anxiety Symptoms Questionnaire Anhedonic Depression Scale: A Receiver-Operating Characteristic Analysis

    Bredemeier, Keith; Spielberg, Jeffery M.; Silton, Rebecca Levin; Berenbaum, Howard; Heller, Wendy; Miller, Gregory A.

    2010-01-01

    The present study examined the utility of the anhedonic depression scale from the Mood and Anxiety Symptoms Questionnaire (MASQ-AD scale) as a way to screen for depressive disorders. Using receiver-operating characteristic analysis, we examined the sensitivity and specificity of the full 22-item MASQ-AD scale, as well as the 8- and 14-item


  15. Maternal and paternal alcoholism and depressive mood in college students: parental relationships as mediators of ACOA-depressive mood link.

    Kelley, Michelle L; Pearson, Matthew R; Trinh, Scott; Klostermann, Keith; Krakowski, Kristina

    2011-07-01

    The present study examined whether suspecting one's mother versus father of alcohol abuse was associated with parent-offspring relationships, and the degree to which parent-child relationships were associated with depressive symptoms. As compared to non-ACOAs (n=288), ACOAs (n=100) reported more negative parent-child relationships (i.e., greater alienation, poorer communication, less trust, greater emotional longing, and more negative attitudes toward the parent) and increased depressive symptoms on the POMS (McNair, Lorr, & Droppleman, 1992). A closer look revealed that suspected maternal alcohol abuse was associated with more negative mother-child relationships, whereas suspected paternal alcohol abuse was associated with more negative father-child relationships. Both maternal alcohol abuse and paternal alcohol abuse predicted depressive symptoms. PMID:21392890

  16. Links between Antisocial Behavior and Depressed Mood: The Role of Life Events and Attributional Style

    Rowe, Richard; Maughan, Barbara; Eley, Thalia C.

    2006-01-01

    Comorbidity between antisocial behavior and depression in adolescence is widely recognized. This paper examines whether links with depressed mood differ among three subtypes of antisocial behavior: oppositionality, physical aggression and delinquency. In addition we examine two possible contributors to these links: negative life events that are


  17. Links between Friendship Relations and Early Adolescents' Trajectories of Depressed Mood

    Brendgen, Mara; Lamarche, Veronique; Wanner, Brigitte; Vitaro, Frank

    2010-01-01

    The present study examined to what extent different types of friendship experiences (i.e., friendlessness, having depressed friends, and having nondepressed friends) are associated with early adolescents' longitudinal trajectories of depressed mood. On the basis of a sample of 201 youths (108 girls, 93 boys), we identified 3 distinct longitudinal…

  18. Mood-congruent true and false memory: Effects of depression

    Howe, M. L.; Malone, C.

    2011-01-01

    The Deese/Roediger-McDermott paradigm was used to investigate the effect of depression on true and false recognition. In this experiment, true and false recognition was examined across positive, neutral, negative, and depression-relevant lists for individuals with and without a diagnosis of major depressive disorder. Results showed that participants with major depressive disorder falsely recognized significantly more depression-relevant words than non-depressed controls. These findings also p...

  19. Depression

    Kessing, Lars Veddel; Bukh, Jens Drachmann

    2014-01-01

    these diagnostic criteria represent an oversimplification, which has blurred the concept of depression. We suggest a greater emphasis on the depressed mood as the core symptom of depression, which may increase the specificity of the diagnosis. Furthermore, basic principles for the treatment of......The prevalence of depression is not clearly established, but estimated to 3-4% in a Danish questionnaire study. Lifetime's prevalences of 12-17% are reported in other community samples. In the current diagnostic system depression is defined categorically and operationally. It has been argued, that...... depression are presented....

  20. Depression

    Kessing, Lars Veddel; Bukh, Jens Otto Drachmann

    2014-01-01

    The prevalence of depression is not clearly established, but estimated to 3-4% in a Danish questionnaire study. Lifetime's prevalences of 12-17% are reported in other community samples. In the current diagnostic system depression is defined categorically and operationally. It has been argued, that...... these diagnostic criteria represent an oversimplification, which has blurred the concept of depression. We suggest a greater emphasis on the depressed mood as the core symptom of depression, which may increase the specificity of the diagnosis. Furthermore, basic principles for the treatment of...... depression are presented....

  1. Does Improving Mood in Depressed Patients Alter Factors That May Affect Cardiovascular Disease Risk?

    Taylor, C. Barr; Conrad, Ansgar; Wilhelm, Frank H.; Strachowski, Diane; Khaylis, Anna; Neri, Eric; Giese-Davis, Janine; Roth, Walton T.; Cooke, John P.; Kraemer, Helena; Spiegel, David

    2009-01-01

    To determine if improvement in mood would ameliorate autonomic dysregulation, HPA dysfunction, and typical risk factors and C-reactive protein in depressed patients with elevated cardiovascular disease risk (CVD), 48 depressed participants with elevated cardiovascular risk factors were randomized to a cognitive behavioral intervention (CBT) or a waiting list control (WLC) condition. Twenty non-depressed age and risk-matched controls were also recruited. Traditional risk factors (e.g., lipids,...

  2. Depressed Mood and Lateralized Prefrontal Activity During a Stroop Task in Adolescent Children

    Killgore, William D.S.; Gruber, Staci A.; Yurgelun-Todd, Deborah A.

    2007-01-01

    Negative affective style and depressive disorders share a common pattern of brain activation asymmetry in adults, characterized by reduced left relative to right prefrontal activation. It is not clear whether a similar pattern of asymmetry is related to depressive mood state during the period of adolescence, an important stage of emotional and brain development. We correlated Beck Depression Inventory (BDI) scores from 16 adolescents with prefrontal, anterior cingulate, and amygdala activity ...

  3. Induction of cytokine synthesis and fever suppresses REM sleep and improves mood in patients with major depression.

    Bauer, J; Hohagen, F; Gimmel, E; Bruns, F; Lis, S; Krieger, S; Ambach, W; Guthmann, A; Grunze, H; Fritsch-Montero, R

    1995-11-01

    Beneficial effects of inflammatory events on certain psychiatric disorders, including depression, were reported sporadically by ancient Greek physicians, but have been described also in our times by a few psychiatrists during the past decades. During febrile inflammatory events, mediators of the immune system such as interleukin-1 can be detected in the brain and may act on their respective receptors which have also been demonstrated in the brain. Since cytokines such as interleukin-1 have been shown in animal studies to exert sedative behavioral effects, to be somnogenic, and to induce slow-wave sleep (SWS), we performed a pilot study to evaluate scientifically the anecdotically reported beneficial effects of inflammatory states on depressive disorders. Mood and sleep parameters were monitored in seven drug-free, severely depressed patients before, during, and after the administration of a single dose of endotoxin. All patients responded with a short pulse of increased synthesis of the cytokines tumor necrosis factor, interleukin-1, and interleukin-6 and elevated body temperature for several hours. During the night following endotoxin administration, rapid eye movement (REM) sleep was significantly suppressed, while changes in slow wave sleep were not significant. During the next day, all patients were in a significantly improved mood; however a rebound of REM sleep was observed in the second night after endotoxin administration and mood worsened again during the next days, indicating an only transient beneficial effect of the treatment. PMID:8573663

  4. A Daily Diary Study of Co-Rumination, Stressful Life Events, and Depressed Mood in Late Adolescents

    White, Megan E.; Shih, Josephine H.

    2012-01-01

    The purpose of this study was to extend the research on co-rumination and depressed mood by examining the impact of co-rumination on depressed mood on a daily basis while controlling for the effects of daily stress events in a sample of late adolescents. Two-hundred and seventy-nine predominantly Caucasian college students (95 male, 184 female)…

  5. The Role of Depressed Mood and Anger in the Relationship between Family Conflict and Delinquent Behavior

    Sigfusdottir, Inga-Dora; Farkas, George; Silver, Eric

    2004-01-01

    Drawing on R. Agnew's (Foundation for a general strain theory of crime and delinquency. Criminology 30: 47-87, 1992) general strain theory, this paper examines whether depressed mood and anger mediate the effects of family conflict on delinquency. We examine data on 7,758 students, 14-16 years old, attending the compulsory 9th and 10th grades of


  6. Mood Management Intervention for College Smokers with Elevated Depressive Symptoms: A Pilot Study

    Schleicher, Holly E.; Harris, Kari Jo; Campbell, Duncan G.; Harrar, Solomon W.

    2012-01-01

    Objective: This pilot study examined smoking reduction and cessation among college smokers with elevated depressive symptomatology participating in a group-based behavioral counseling, mood management, and motivational enhancement combined intervention (CBT). Participants and Methods: Fifty-eight smokers (smoked 6 days in the past 30) were


  7. Dietary patterns and depressive mood in a multiethnic representative sample of Texas eighth graders

    The purpose of the study was to examine the relation between dietary patterns and depressive mood among 8th grade students in Texas. Data were from the 2004–2005 School Physical Activity and Nutrition study, a multistage probability-based sample of Texas 8th graders. Participants (n=8827; 14.7% Afri...

  8. Expert consensus statement on diagnosis and treatment of cancer-related depressed mood state based on Chinese medicine

    Shaodan Tian

    2015-10-01

    Full Text Available This consensus statement is organized into six parts: 1 Definitions: cancer-related depressed mood state is defined as a group of depressive symptoms, rather than major depressive disorder. Thus, “cancer-related depression” or “depressed mood state” is introduced as standard terminology and associated with the Chinese medicine concept of “yu zheng” (depression syndrome. 2 Pathogenesis: factors including psychological stress, cancer pain, cancer fatigue, sleep disorders, surgery trauma, chemotherapy, and radiation therapy are strongly associated with cancer-related depressed mood state. Crucial elements of pathogenesis are cancer caused by depression, depression caused by cancer, and the concurrence of phlegm, dampness, and stasis from constrained liver-qi and spleen deficiency. 3 Symptoms: these include core symptoms, psychological symptoms, and somatic symptoms. Depressed mood and loss of interest are the main criteria for diagnosis. 4 Clinical evaluation: based on the Mini-International Neuropsychiatric Interview and a numeric rating scale, and taking mood changes during cancer diagnosis and treatment into consideration, a questionnaire can be drafted to distinguish between major depressive disorder and cancer-related depression. The aim is to assist oncology clinicians to identify, treat, and refer patients with cancer-related depression. 5 Diagnosis: diagnosis should be based on the Chinese Classification for Mental Disorders (CCMD-3, taking patients' mood changes during diagnosis and treatment into consideration. 6 Treatment: treatments for cancer-related depression must be performed concurrently with cancer treatment. For mild depression, non-pharmacologic comprehensive therapies, including psychological intervention, music therapy, patient education, physical activity, and acupuncture, are recommended; for moderate depression, classical Chinese herbal formulas based on syndrome pattern differentiation combined with antidepressants are suggested; for severe depressive symptoms that have progressed to major depressive disorder, patients should be referred to a psychiatric clinician for specialized care.

  9. Dejian Mind-Body Intervention on Depressive Mood of Community-Dwelling Adults: A Randomized Controlled Trial

    Chan, Agnes S.; Mei-chun Cheung; Tsui, Wilson J.; Sophia L Sze; Dejian Shi

    2011-01-01

    The present study evaluated the effectiveness of a short-term mind-body intervention program on improving the depressive mood of an adult community sample. Forty adult volunteers with various degrees of depressive mood were randomly assigned to the experimental group (Dejian Mind-Body Intervention, DMBI) and control group (Cognitive-Behavioral Therapy, CBT). For each group, a total of four 90-min weekly sessions were conducted. Treatment-related changes were measured using the Beck Depression...

  10. Depressive Mood and Testosterone Related to Declarative Verbal Memory Decline in Middle-Aged Caregivers of Children with Eating Disorders.

    Romero-Martínez, Ángel; Ruiz-Robledillo, Nicolås; Moya-Albiol, Luis

    2016-01-01

    Caring for children diagnosed with a chronic psychological disorder such as an eating disorder (ED) can be used as a model of chronic stress. This kind of stress has been reported to have deleterious effects on caregivers' cognition, particularly in verbal declarative memory of women caregivers. Moreover, high depressive mood and variations in testosterone (T) levels moderate this cognitive decline. The purpose of this study was to characterize whether caregivers of individuals with EDs (n = 27) show declarative memory impairments compared to non-caregivers caregivers (n = 27), using for this purpose a standardized memory test (Rey's Auditory Verbal Learning Test). Its purpose was also to examine the role of depressive mood and T in memory decline. Results showed that ED caregivers presented high depressive mood, which was associated to worse verbal memory performance, especially in the case of women. In addition, all caregivers showed high T levels. Nonetheless, only in the case of women caregivers did T show a curvilinear relationship with verbal memory performance, meaning that the increases of T were associated to the improvement in verbal memory performance, but only up to a certain point, as after such point T continued to increase and memory performance decreased. Thus, chronic stress due to caregiving was associated to disturbances in mood and T levels, which in turn was associated to verbal memory decline. These findings should be taken into account in the implementation of intervention programs for helping ED caregivers cope with caregiving situations and to prevent the risk of a pronounced verbal memory decline. PMID:27072418

  11. Depressive Mood and Testosterone Related to Declarative Verbal Memory Decline in Middle-Aged Caregivers of Children with Eating Disorders

    Romero-Martínez, Ángel; Ruiz-Robledillo, Nicolås; Moya-Albiol, Luis

    2016-01-01

    Caring for children diagnosed with a chronic psychological disorder such as an eating disorder (ED) can be used as a model of chronic stress. This kind of stress has been reported to have deleterious effects on caregivers’ cognition, particularly in verbal declarative memory of women caregivers. Moreover, high depressive mood and variations in testosterone (T) levels moderate this cognitive decline. The purpose of this study was to characterize whether caregivers of individuals with EDs (n = 27) show declarative memory impairments compared to non-caregivers caregivers (n = 27), using for this purpose a standardized memory test (Rey’s Auditory Verbal Learning Test). Its purpose was also to examine the role of depressive mood and T in memory decline. Results showed that ED caregivers presented high depressive mood, which was associated to worse verbal memory performance, especially in the case of women. In addition, all caregivers showed high T levels. Nonetheless, only in the case of women caregivers did T show a curvilinear relationship with verbal memory performance, meaning that the increases of T were associated to the improvement in verbal memory performance, but only up to a certain point, as after such point T continued to increase and memory performance decreased. Thus, chronic stress due to caregiving was associated to disturbances in mood and T levels, which in turn was associated to verbal memory decline. These findings should be taken into account in the implementation of intervention programs for helping ED caregivers cope with caregiving situations and to prevent the risk of a pronounced verbal memory decline. PMID:27072418

  12. Depressive Mood Among Within-Country Migrants in Periurban Shantytowns of Lima, Peru.

    Ruiz-Grosso, Paulo; Bernabe-Ortiz, Antonio; Diez-Canseco, Francisco; Gilman, Robert H; Checkley, William; Bennett, Ian M; Miranda, J Jaime

    2015-12-01

    In low- and middle-income countries, migration to urban settings has reshaped the sprawl and socio demographic profiles of major cities. Depressive episodes make up a large portion of the burden of disease worldwide and are related to socio-demographic disruptions. As a result of terrorism, political upheaval, followed by economic development, Peru has undergone major demographic transitions over the previous three decades including large migrations within the country. We aimed to determine the prevalence of current depressive mood and its relationship with parameters of internal migration, i.e. region of origin, age at migration, and years since migration. A community-wide census was carried out between January and June 2010 within a shantytown immigrant receiving community in Lima, Peru. One male or female adult per household completed a survey. Depressive mood was assessed with a 2-item Center for Epidemiologic Studies Depression (CESD) scale. Migration-related variables included place of birth, duration of residence in Lima, and age at migration. Prevalence ratios (PR) and 95% confidence intervals (95% CI) were calculated. A total of 8,551 out of 9,561 participants, response rate 89%, participated in the census. Of these, 8,091 records were analyzed: 71.8% were women [average age 39.4 (SD 13.9 years)] and 59.3% were immigrants. The overall prevalence of individuals with current depressive mood was 17.1% (95% CI 16.2-17.9%) and varied significantly by all socio-demographic and migration variables assessed. On unadjusted analyses, immigrants to Lima had higher prevalence of depressive mood if they originated in other costal or Andean areas, had lived in Lima for more than 20 years, or were migrants. PMID:25367530

  13. Associations between Sexual Abuse and Family Conflict/Violence, Self-Injurious Behavior, and Substance Use: The Mediating Role of Depressed Mood and Anger

    Asgeirsdottir, Bryndis Bjork; Sigfusdottir, Inga Dora; Gudjonsson, Gisli H.; Sigurdsson, Jon Fridrik

    2011-01-01

    Objective: To examine whether depressed mood and anger mediate the effects of sexual abuse and family conflict/violence on self-injurious behavior and substance use. Methods: A cross-sectional national survey was conducted including 9,085 16-19 year old students attending all high schools in Iceland in 2004. Participants reported frequency of


  14. Associations between Sexual Abuse and Family Conflict/Violence, Self-Injurious Behavior, and Substance Use: The Mediating Role of Depressed Mood and Anger

    Asgeirsdottir, Bryndis Bjork; Sigfusdottir, Inga Dora; Gudjonsson, Gisli H.; Sigurdsson, Jon Fridrik

    2011-01-01

    Objective: To examine whether depressed mood and anger mediate the effects of sexual abuse and family conflict/violence on self-injurious behavior and substance use. Methods: A cross-sectional national survey was conducted including 9,085 16-19 year old students attending all high schools in Iceland in 2004. Participants reported frequency of…

  15. Cognitive Variables and Depressed Mood in Adults with Intellectual Disability

    Esbensen, A. J.; Benson, B. A.

    2005-01-01

    Background Cognitive theory forms the foundation for cognitive therapy. There has been little research on cognitive theories and cognitive variables associated with depression in individuals with intellectual disability (ID). The current study examined cognitive variables of automatic thoughts, cognitive triad, hopelessness, attributions and


  16. Glucocorticoid mediated regulation of inflammation in human monocytes is associated with depressive mood and obesity.

    Cheng, Tiefu; Dimitrov, Stoyan; Pruitt, Christopher; Hong, Suzi

    2016-04-01

    Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is observed in various conditions, including depression and obesity, which are also often related. Glucocorticoid (GC) resistance and desensitization of peripheral GC receptors (GRs) are often the case in HPA dysregulation seen in depression, and GC plays a critical role in regulation of inflammation. Given the growing evidence that inflammation is a central feature of some depression cases and obesity, we aimed to investigate the immune-regulatory role of GC-GR in relation to depressive mood and obesity in 35 healthy men and women. Depressive mood and level of obesity were assessed, using Beck Depression Inventory (BDI-Ia) and body mass index (BMI), respectively. We measured plasma cortisol levels via enzyme-linked immunosorbent assay and lipopolysaccharide-stimulated intracellular tumor necrosis factor (TNF) production by monocytes, using flow cytometry. Cortisol sensitivity was determined by the difference in monocytic TNF production between the conditions of 1 and 0ÎŒM cortisol incubation ("cortisol-mediated inflammation regulation, CoMIR"). GR vs. mineralocorticoid receptor (MR) antagonism for CoMIR was examined by using mifepristone and spironolactone. A series of multiple regression analyses were performed to investigate independent contribution of depressive mood vs. obesity after controlling for age, gender, systolic blood pressure (SBP), and plasma cortisol in predicting CoMIR. CoMIR was explained by somatic subcomponents of depressive mood (BDI-S: ÎČ=-0.499, p=0.001), or BMI (ÎČ=-0.466, p<0.01) in separate models. The effects of BMI disappeared when BDI-S was controlled for in the model, while BDI-S remained a significant independent predictor for CoMIR (ÎČ=-0.369, p<0.05). However, BMI remained the only independent predictor when BDI-T or BDI-C were controlled for in the model. Mediation analyses also revealed that the relationship between BMI and CoMIR was mediated by BDI-S. The exploratory findings of the relative GR vs. MR roles in CoMIR, using GR and MR blockers, indicated that CoMIR in our cellular model was predominantly mediated by GRs at the higher cortisol dose (1ÎŒM). There was initial indication that greater obesity and somatic depressive symptoms were associated with smaller efficacy of the blockers, which warrants further investigation. Our findings, although in a preclinical sample, signify the shared pathophysiology of immune dysregulation in depression and obesity and warrant further mechanistic investigation. PMID:26829709

  17. An Instrumental Variable Probit (IVP Analysis on Depressed Mood in Korea: The Impact of Gender Differences and Other Socio-Economic Factors

    Lara Gitto

    2015-08-01

    Full Text Available Background Depression is a mental health state whose frequency has been increasing in modern societies. It imposes a great burden, because of the strong impact on people’s quality of life and happiness. Depression can be reliably diagnosed and treated in primary care: if more people could get effective treatments earlier, the costs related to depression would be reversed. The aim of this study was to examine the influence of socio-economic factors and gender on depressed mood, focusing on Korea. In fact, in spite of the great amount of empirical studies carried out for other countries, few epidemiological studies have examined the socio-economic determinants of depression in Korea and they were either limited to samples of employed women or did not control for individual health status. Moreover, as the likely data endogeneity (i.e. the possibility of correlation between the dependent variable and the error term as a result of autocorrelation or simultaneity, such as, in this case, the depressed mood due to health factors that, in turn might be caused by depression, might bias the results, the present study proposes an empirical approach, based on instrumental variables, to deal with this problem. Methods Data for the year 2008 from the Korea National Health and Nutrition Examination Survey (KNHANES were employed. About seven thousands of people (N= 6,751, of which 43% were males and 57% females, aged from 19 to 75 years old, were included in the sample considered in the analysis. In order to take into account the possible endogeneity of some explanatory variables, two Instrumental Variables Probit (IVP regressions were estimated; the variables for which instrumental equations were estimated were related to the participation of women to the workforce and to good health, as reported by people in the sample. Explanatory variables were related to age, gender, family factors (such as the number of family members and marital status and socio-economic factors (such as education, residence in metropolitan areas, and so on. As the results of the Wald test carried out after the estimations did not allow to reject the null hypothesis of endogeneity, a probit model was run too. Results Overall, women tend to develop depression more frequently than men. There is an inverse effect of education on depressed mood (probability of -24.6% to report a depressed mood due to high school education, as it emerges from the probit model marginal effects, while marital status and the number of family members may act as protective factors (probability to report a depressed mood of -1.0% for each family member. Depression is significantly associated with socio-economic conditions, such as work and income. Living in metropolitan areas is inversely correlated with depression (probability of -4.1% to report a depressed mood estimated through the probit model: this could be explained considering that, in rural areas, people rarely have immediate access to high-quality health services. Conclusion This study outlines the factors that are more likely to impact on depression, and applies an IVP model to take into account the potential endogeneity of some of the predictors of depressive mood, such as female participation to workforce and health status. A probit model has been estimated too. Depression is associated with a wide range of socioeconomic factors, although the strength and direction of the association can differ by gender. Prevention approaches to contrast depressive symptoms might take into consideration the evidence offered by the present study.

  18. Physical activity, depressed mood and pregnancy worries in European obese pregnant women

    de Wit, Linda; Jelsma, Judith G M; van Poppel, Mireille N M; Bogaerts, Annick; Simmons, David; Desoye, Gernot; Corcoy, Rosa; Kautzky-Willer, Alexandra; Harreiter, Jürgen; van Assche, Andre; Devlieger, Roland; Timmerman, Dirk; Hill, David; Damm, Peter; Mathiesen, Elisabeth R; Wender-Ozegowska, Ewa; Zawiejska, Agnieszka; Rebollo, Pablo; Lapolla, Annunziata; Dalfrà, Maria G; Del Prato, Stefano; Bertolotto, Alessandra; Dunne, Fidelma; Jensen, Dorte M; Andersen, Liselotte; Snoek, Frank J

    2015-01-01

    -related worries with the Cambridge Worry Scale (CWS). In addition, socio-demographic characteristics, lifestyle factors, and perceptions and attitude regarding weight management and physical activity were measured. Linear regression analyses were performed to assess the association of mental health status with...... with less physical activity. The combined risk of poor mental health and low physical activity levels makes women vulnerable for pregnancy complications. Whether a depressed mood may be a barrier for improving physical activity warrants further study.......BACKGROUND: The purpose of this study was to examine the association between mental health status (i.e. depressed mood and pregnancy-related worries) and objectively measured physical activity levels in obese pregnant women from seven European countries. METHODS: Baseline data from the vitamin D...

  19. Body Dissatisfaction Prospectively Predicts Depressive Mood and Low Self-Esteem in Adolescent Girls and Boys

    Paxton, Susan J.; Neumark-Sztainer, Dianne; Hannan, Peter J.; Eisenberg, Marla E.

    2006-01-01

    This research examined whether body dissatisfaction prospectively predicted depressive mood and low self-esteem in adolescent girls and boys 5 years later. Participants were early-adolescent girls (n = 440, Time 1 M age = 12.7 years) and boys (n = 366, Time 1 M age = 12.8 years) and midadolescent girls (n = 946, Time 1 M age = 15.8 years) and boys


  20. Physical activity, depressed mood and pregnancy worries in European obese pregnant women

    de Wit, Linda; Jelsma, Judith G M; van Poppel, Mireille N M; Bogaerts, Annick; Simmons, David; Desoye, Gernot; Corcoy, Rosa; Kautzky-Willer, Alexandra; Harreiter, JĂŒrgen; van Assche, Andre; Devlieger, Roland; Timmerman, Dirk; Hill, David; Damm, Peter; Mathiesen, Elisabeth R; Wender-Ozegowska, Ewa; Zawiejska, Agnieszka; Rebollo, Pablo; Lapolla, Annunziata; DalfrĂ , Maria G; Del Prato, Stefano; Bertolotto, Alessandra; Dunne, Fidelma; Jensen, Dorte M; Andersen, Liselotte; Snoek, Frank J

    2015-01-01

    BACKGROUND: The purpose of this study was to examine the association between mental health status (i.e. depressed mood and pregnancy-related worries) and objectively measured physical activity levels in obese pregnant women from seven European countries. METHODS: Baseline data from the vitamin D...... MVPA and sedentary behaviour. RESULTS: A total of 98 obese pregnant women from Austria, Belgium, Ireland, Italy, Poland, Spain and the Netherlands were included. Women had a mean age of 31.6 ± 5.8 years, a pre-pregnancy BMI of 34.1 ± 4.3 kg/m(2), and were on average 15.4 ± 2.8 weeks pregnant. WHO-5...... levels were found for women with no, some, or many pregnancy worries. Depressed mood and pregnancy-related worries were not associated with sedentary behaviour. CONCLUSIONS: These findings suggest that in pregnant women who are obese, a depressed mood, but not pregnancy-related worries, may be associated...

  1. The examination of sport managers and coaches’ stress levels and depressed mood at work in Turkey

    Bilge Donuk

    2013-04-01

    Full Text Available This paper is an investigation of stress levels and depressed mood at work in sport managers and coaches. Three different questionnaires were applied to professional sport managers (n=60 and coaches (n=52 in Turkey to regard to potential sources of stress before, during and after competitions. This sample represented approximately 21% of the total professional football, basketball and volleyball clubs in Turkey. The questionnaires used are “Perceived Stress Questionnaire”, “Anxiety-Stress Questionnaire” and “Depressed Mood at Work Questionnaire”. Our findings indicated that: The aim of first questionnaire was to assess perceived stressful situations and results show that general stress levels of managers and coaches are under the average. When we examine the second questionnaire consisting of health, physical condition, tension caused by stress; it is seen that negative effects of these factors increase. At last; according to the depressed mood at work questionnaire which evaluates the physiological conditions related to stress; it’s found out that both managers and coaches aren’t satisfied with their working atmosphere and managers’ unhappiness levels are higher than coaches are.

  2. Combining an SSRI with an anticonvulsant in depressed patients with dysphoric mood: an open study

    Cascavilla Isabella

    2007-02-01

    Full Text Available Abstract Background Several patients with unipolar depression present with prominent dysphoric mood. We aimed at examining the effectiveness of the combination of an SSRI with an anticonvulsant in such patients. Methods Thirty-five newly admitted outpatients with substantial anger, irritability, aggressiveness or hostility who were diagnosed a DSM-IV unipolar depressive disorder were rated on the Hamilton Depression Rating Scale (HDRS, the Clinical Global Improvement (CGI scale, and a scale for the rapid dimensional assessment (SVARAD, were prescribed an SSRI and an anticonvulsant (usually valproate, and were followed up for 12 weeks. Repeated measures analysis of variance was used to test for within-subject changes in scale scores over time. Results Thirty-two and 23 patients attended the follow-up visits 4 and 12 weeks later, respectively. Significant decreases (p Conclusion Although our study has several limitations, we observed a remarkable improvement in most unipolar depressed outpatients with dysphoric mood treated with an SSRI and an anticonvulsant. The effectiveness of anticonvulsants might be linked to their action on symptoms of aggression and behavioural activation.

  3. Methadone-Maintained Pregnant Patients and Current Mood Disorder: Delivery and Neonatal Outcomes

    Tuten, Michelle; Heil, Sarah H.; O'Grady, Kevin E.; Fitzsimons, Heather; Chisolm, Margaret S.; Jones, Hendrée E.

    2009-01-01

    Methadone-maintained pregnant patients with mood disorders have compromised treatment outcomes (1). This study examined the relationship between the presence of mood disorders and delivery and neonatal outcomes. Participants were categorized into two groups: no current mood disorder (n=30) or primary mood disorder (n=38). The mood disorder group reported more serious lifetime and current depression than did the no current mood disorder group. Neonates from mothers with mood disorders had a lo...

  4. Infant sleep and feeding patterns are associated with maternal sleep, stress, and depressed mood in women with a history of major depressive disorder (MDD).

    Sharkey, Katherine M; Iko, Ijeoma N; Machan, Jason T; Thompson-Westra, Johanna; Pearlstein, Teri B

    2016-04-01

    Our goal was to examine associations of infant sleep and feeding patterns with maternal sleep and mood among women at risk for postpartum depression. Participants were 30 women (age ± SD = 28.3 ± 5.1 years) with a history of MDD (but not in a mood episode at enrollment) who completed daily sleep diaries, wore wrist actigraphs to estimate sleep, and had their mood assessed with the Hamilton Depression Rating Scale (HAM-D-17) during four separate weeks of the perinatal period (33 weeks pregnancy and weeks 2, 6, and 16 postpartum). They logged their infants' sleep and feeding behaviors daily and reported postnatal stress on the Childcare Stress Inventory (CSI) at week 16. Mothers' actigraphically estimated sleep showed associations with infant sleep and feeding patterns only at postpartum week 2. Shorter duration of the longest infant-sleep bout was associated with shorter maternal sleep duration (p = .02) and lower sleep efficiency (p = .04), and maternal sleep efficiency was negatively associated with the number of infant-sleep bouts (p = .008) and duration of infant feeding (p = .008). Neither infant sleep nor feeding was associated with maternal sleep at 6 or 16 weeks, but more disturbed infant sleep and more frequent feeding at 6 weeks were associated with higher HAM-D scores at 6 and 16 weeks and higher CSI scores. Sleep in the mother-infant dyad is most tightly linked in the early postpartum weeks, but mothers continue to experience disturbed sleep and infant sleep and feeding behaviors continue to be associated with mothers' depressive symptoms and stress ratings as long as 16 weeks postpartum. These data imply that interventions designed to improve maternal sleep and postpartum mood should include both mothers and infants because improving infant sleep alone is not likely to improve maternal sleep, and poor infant sleep is linked to postpartum depression and stress. PMID:26228760

  5. The role of Personality, Mood, Subjective Health, and Stress in Depressive Symptoms among High School Students

    K. Gunnar Götestam

    2008-09-01

    Full Text Available Background and Objectives: Traditionally, depression among adolescents has been considered uncommon, with around 5% estimated to suffer from depressive disorder. The purpose is to investigate occurrence and psychological correlates for depressive symptoms in male and female high school adolescents in urban and rural settings. Methods: Participants were 1,069 high school students (response rate 92.0% with a mean age of 17.6 years. The instruments used were the Zung Depression Self-Rating Scale (SDS, Life Regard Index (LRI, the Neuroticism scale by Eysenck (EPQ-N, the Tension and Effort Stress Inventory (TESI, the Subjective Health Complaints scale (SHC, and the Sense of Humour Questionnaire (SHQ-6. Results: Analyzes of Variance showed sex and urban/rural main effects, and/or interactions (boys and rural students showing highest positive ratings. Stepwise regression analyzes on depression showed all but the TESI variables to significantly explain 41% of the variance in depression. The Sense of Humour and Life Regard Index were strong contributors to depression (55% of variation when effects of bodily complaints and scores on stressors and efforts were eliminated. Conclusions: The present study showed an unexpectedly high prevalence of severe (12.7% as well as moderate depressive symptoms (total of 49.2%. Therefore, the results indicate an increase of adolescent depression in recent years. Negative and positive mood, as well as sense of humour, goals in life, and fulfilment of goals seemed to be protecting. Prevalence of depressive symptoms in adolescents was shown to be higher than expected. Positive resource variables appeared to be protecting.

  6. Thought suppression as a mediator of the association between depressed mood and prescription opioid craving among chronic pain patients.

    Garland, Eric L; Brown, Samantha M; Howard, Matthew O

    2016-02-01

    Emerging research suggests that prescription opioid craving is associated with negative mood and depression, but less is known about cognitive factors linking depressive symptoms to opioid craving among adults with chronic pain. The present cross-sectional study examined thought suppression as a mediator of the relation between depression and prescription opioid craving in a sample of chronic pain patients receiving long-term opioid pharmacotherapy. Data were obtained from 115 chronic pain patients recruited from primary care, pain, and neurology clinics who had taken prescription opioids daily or nearly every day for ?90 days prior to assessment. In this sample, 60 % of participants met DSM-IV criteria for current major depressive disorder. Depressed mood (r = .36, p thought suppression (r = .33, p thought suppression on the association between depressed mood and opioid craving (indirect effect = .09, 95 % CI .01, .20). Sensitivity analyses showed a similar indirect effect of suppression linking major depressive disorder diagnosis and opioid craving. Attempts to suppress distressing and intrusive thoughts may result in increased craving to use opioids among chronic pain patients with depressive symptoms. Results highlight the need for interventions that mitigate thought suppression among adults with pain and mood disorders. PMID:26345263

  7. Depressed visual field and mood are associated with sleep disorder in glaucoma patients

    Ayaki, Masahiko; Shiba, Daisuke; Negishi, Kazuno; Tsubota, Kazuo

    2016-01-01

    The aim of the present study was to evaluate sleep and mood disorders and related ocular parameters in glaucoma patients. We focused on visual fields and the retinal nerve fibre layer, because decreased circadian photoreception by damaged intrinsically photosensitive retinal ganglion cells is suspected in glaucoma. A cross-sectional study was performed on 140 subjects: 69 with glaucoma and 71 normal controls. Individuals with cataract, dry eye, or retinal pathology were excluded from the study. Participants completed the Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS) and underwent comprehensive ophthalmological examinations for glaucoma. Patients with advanced glaucoma had significantly worse PSQI scores than normal controls (P glaucoma patients was correlated with visual field loss and mood status. PMID:27168309

  8. Depressed visual field and mood are associated with sleep disorder in glaucoma patients.

    Ayaki, Masahiko; Shiba, Daisuke; Negishi, Kazuno; Tsubota, Kazuo

    2016-01-01

    The aim of the present study was to evaluate sleep and mood disorders and related ocular parameters in glaucoma patients. We focused on visual fields and the retinal nerve fibre layer, because decreased circadian photoreception by damaged intrinsically photosensitive retinal ganglion cells is suspected in glaucoma. A cross-sectional study was performed on 140 subjects: 69 with glaucoma and 71 normal controls. Individuals with cataract, dry eye, or retinal pathology were excluded from the study. Participants completed the Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS) and underwent comprehensive ophthalmological examinations for glaucoma. Patients with advanced glaucoma had significantly worse PSQI scores than normal controls (P glaucoma patients was correlated with visual field loss and mood status. PMID:27168309

  9. Adolescent Self-Control Predicts Joint Trajectories of Marijuana Use and Depressive Mood into Young Adulthood Among Urban African Americans and Puerto Ricans

    Pahl, Kerstin; Brook, Judith S.; LEE, JUNG YEON

    2013-01-01

    Previous studies have identified an association between depressive mood and marijuana use. We examined adolescent self-control as a predictor of membership in joint developmental trajectories of depressive mood and marijuana use from adolescence to young adulthood. Urban African Americans and Puerto Ricans (N=838) were sampled when participants were on average 14, 19, 24, and 29 years old. Using growth mixture modeling, four joint trajectory groups of depressive mood and marijuana use were es...

  10. Memory mood congruency phenomenon in bipolar I disorder and major depression disorder patients

    V.B. Delgado

    2012-09-01

    Full Text Available The objective of the present study was to evaluate memory performance in tasks with and without affective content (to confirm the mood congruency phenomenon in acutely admitted patients with bipolar I disorder (BD and major depression disorder (MDD and in healthy participants. Seventy-eight participants (24 BD, 29 MDD, and 25 healthy controls were evaluated. Three word lists were used as the memory task with affective content (positive, negative and indifferent. Psychiatric symptoms were also evaluated with rating scales (Young Mania Rating Scale for mania and Hamilton Depression Rating Scale for depression. Patients were selected during the first week of hospitalization. BD patients showed higher scores in the word span with positive tone than MDD patients and healthy controls (P = 0.002. No other difference was observed for tests with affective tone. MDD patients presented significantly lower scores in the Mini-Mental State Exam, logical memory test, visual recognition span, and digit span, while BD patients presented lower scores in the visual recognition test and digit span. Mood congruency effect was found for word span with positive tone among BD patients but no similar effect was observed among MDD patients for negative items. MDD patients presented more memory impairment than BD patients, but BD patients also showed memory impairment

  11. Mental Health and Functional Outcomes of Maternal and Adolescent Reports of Adolescent Depressive Symptoms

    Rice, Frances; Lifford, Kate J.; Thomas, Hollie V.; Thapar, Anita

    2007-01-01

    Objective: To assess the value of maternal and self-ratings of adolescent depression by investigating the extent to which these reports predicted a range of mental health and functional outcomes 4 years later. The potential influence of mother's own depressed mood on her ratings of adolescent depression and suicidal ideation on adolescent outcome


  12. Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression.

    Hieronymus, F; Emilsson, J F; Nilsson, S; Eriksson, E

    2016-04-01

    The recent questioning of the antidepressant effect of selective serotonin reuptake inhibitors (SSRIs) is partly based on the observation that approximately half of company-sponsored trials have failed to reveal a significant difference between active drug and placebo. Most of these have applied the Hamilton depression rating scale to assess symptom severity, the sum score for its 17 items (HDRS-17-sum) serving as effect parameter. In this study, we examined whether the negative outcomes of many SSRI trials may be partly caused by the use of this frequently questioned measure of response. We undertook patient-level post-hoc analyses of 18 industry-sponsored placebo-controlled trials regarding paroxetine, citalopram, sertraline or fluoxetine, and including in total 6669 adults with major depression, the aim being to assess what the outcome would have been if the single item depressed mood (rated 0-4) had been used as a measure of efficacy. In total, 32 drug-placebo comparisons were reassessed. While 18 out of 32 comparisons (56%) failed to separate active drug from placebo at week 6 with respect to reduction in HDRS-17-sum, only 3 out of 32 comparisons (9%) were negative when depressed mood was used as an effect parameter (P<0.001). The observation that 29 out of 32 comparisons detected an antidepressant signal from the tested SSRI suggests the effect of these drugs to be more consistent across trials than previously assumed. Further, the frequent use of the HDRS-17-sum as an effect parameter may have distorted the current view on the usefulness of SSRIs and hampered the development of novel antidepressants. PMID:25917369

  13. Consistent superiority of selective serotonin reuptake inhibitors over placebo in reducing depressed mood in patients with major depression

    Hieronymus, F; Emilsson, J F; Nilsson, S; Eriksson, E

    2016-01-01

    The recent questioning of the antidepressant effect of selective serotonin reuptake inhibitors (SSRIs) is partly based on the observation that approximately half of company-sponsored trials have failed to reveal a significant difference between active drug and placebo. Most of these have applied the Hamilton depression rating scale to assess symptom severity, the sum score for its 17 items (HDRS-17-sum) serving as effect parameter. In this study, we examined whether the negative outcomes of many SSRI trials may be partly caused by the use of this frequently questioned measure of response. We undertook patient-level post-hoc analyses of 18 industry-sponsored placebo-controlled trials regarding paroxetine, citalopram, sertraline or fluoxetine, and including in total 6669 adults with major depression, the aim being to assess what the outcome would have been if the single item depressed mood (rated 0–4) had been used as a measure of efficacy. In total, 32 drug-placebo comparisons were reassessed. While 18 out of 32 comparisons (56%) failed to separate active drug from placebo at week 6 with respect to reduction in HDRS-17-sum, only 3 out of 32 comparisons (9%) were negative when depressed mood was used as an effect parameter (P<0.001). The observation that 29 out of 32 comparisons detected an antidepressant signal from the tested SSRI suggests the effect of these drugs to be more consistent across trials than previously assumed. Further, the frequent use of the HDRS-17-sum as an effect parameter may have distorted the current view on the usefulness of SSRIs and hampered the development of novel antidepressants. PMID:25917369

  14. Mood Reactivity Rather than Cognitive Reactivity Is Predictive of Depressive Relapse: A Randomized Study with 5.5-Year Follow-Up

    van Rijsbergen, Gerard D.; Bockting, Claudi L. H.; Burger, Huibert; Spinhoven, Philip; Koeter, Maarten W. J.; Ruhe, Henricus G.; Hollon, Steven D.; Schene, Aart H.

    2013-01-01

    Objective: The current study examined whether cognitive reactivity, cognitive extremity reactivity, and mood reactivity following mood provocation predicted relapse in depression over 5.5 years. Additionally, this study was the 1st to examine whether changes in cognitive reactivity and mood reactivity following preventive cognitive therapy (PCT)


  15. Mood Reactivity Rather than Cognitive Reactivity Is Predictive of Depressive Relapse: A Randomized Study with 5.5-Year Follow-Up

    van Rijsbergen, Gerard D.; Bockting, Claudi L. H.; Burger, Huibert; Spinhoven, Philip; Koeter, Maarten W. J.; Ruhe, Henricus G.; Hollon, Steven D.; Schene, Aart H.

    2013-01-01

    Objective: The current study examined whether cognitive reactivity, cognitive extremity reactivity, and mood reactivity following mood provocation predicted relapse in depression over 5.5 years. Additionally, this study was the 1st to examine whether changes in cognitive reactivity and mood reactivity following preventive cognitive therapy (PCT)…

  16. Depressed mood: changes during a five-year follow-up in 75-year-old men and women in three Nordic localities

    Heikkinen, Riitta-Liisa; Berg, Stig; Avlund, Kirsten; Törmäkangas, Timo

    they predicted depressed mood in this study. The study is a part of a 5-year follow-up of the Nordic comparative NORA study on functional capacity. A 5-year follow-up was carried out with the survivors in 1994. Depressive symptomatology was assessed by the Center for Epidemiologic Studies Depression...... score describing depressed mood (CES-D total scale) in any locality in either men or women. The mean score of those who died during the follow-up period differed significantly from the score of survivors among women in Göteborg and in Glostrup. The most clear predictors for depressed mood in this Nordic...

  17. Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders.

    Frye, M A; Nassan, M; Jenkins, G D; Kung, S; Veldic, M; Palmer, B A; Feeder, S E; Tye, S J; Choi, D S; Biernacka, J M

    2015-01-01

    The objective of this study was to determine whether proteomic profiling in serum samples can be utilized in identifying and differentiating mood disorders. A consecutive sample of patients with a confirmed diagnosis of unipolar (UP n=52) or bipolar depression (BP-I n=46, BP-II n=49) and controls (n=141) were recruited. A 7.5-ml blood sample was drawn for proteomic multiplex profiling of 320 proteins utilizing the Myriad RBM Discovery Multi-Analyte Profiling platform. After correcting for multiple testing and adjusting for covariates, growth differentiation factor 15 (GDF-15), hemopexin (HPX), hepsin (HPN), matrix metalloproteinase-7 (MMP-7), retinol-binding protein 4 (RBP-4) and transthyretin (TTR) all showed statistically significant differences among groups. In a series of three post hoc analyses correcting for multiple testing, MMP-7 was significantly different in mood disorder (BP-I+BP-II+UP) vs controls, MMP-7, GDF-15, HPN were significantly different in bipolar cases (BP-I+BP-II) vs controls, and GDF-15, HPX, HPN, RBP-4 and TTR proteins were all significantly different in BP-I vs controls. Good diagnostic accuracy (ROC-AUCâ©Ÿ0.8) was obtained most notably for GDF-15, RBP-4 and TTR when comparing BP-I vs controls. While based on a small sample not adjusted for medication state, this discovery sample with a conservative method of correction suggests feasibility in using proteomic panels to assist in identifying and distinguishing mood disorders, in particular bipolar I disorder. Replication studies for confirmation, consideration of state vs trait serial assays to delineate proteomic expression of bipolar depression vs previous mania, and utility studies to assess proteomic expression profiling as an advanced decision making tool or companion diagnostic are encouraged. PMID:26645624

  18. Poor quality of life, depressed mood, and memory impairment may be mediated by sleep disruption in patients with Addison's disease.

    Henry, Michelle; Wolf, Pedro S A; Ross, Ian L; Thomas, Kevin G F

    2015-11-01

    Standard replacement therapy for Addison's disease (AD) does not restore a normal circadian rhythm. In fact, hydrocortisone replacement in AD patients likely induces disrupted sleep. Given that healthy sleep plays an important role in improving quality of life, optimizing cognition, and ensuring affect regulation, the aim of this study was to investigate whether poor quality of life, mood alterations, and memory complaints reported by AD patients are associated with their disrupted sleep patterns. Sixty patients with AD and 60 matched healthy controls completed a battery of self-report questionnaires assessing perceived physical and mental health (Short-Form 36), mood (Beck Depression Inventory-II), sleep quality (Pittsburgh Sleep Quality Index), and cognition (Cognitive Failures Questionnaire). A latent variable model revealed that although AD had a significant direct effect on quality of life, the indirect effect of sleep was significantly greater. Furthermore, although AD had no direct effect on cognitive functioning, the indirect effect of sleep was significant. The overall model showed a good fit (comparative fit index = 0.91, root mean square of approximation = 0.09, and standardized root mean square residual = 0.05). Our findings suggest that disrupted sleep, and not the disease per se, may induce poor quality of life, memory impairment, and affect dysregulation in patients with AD. We think that improving sleep architecture may improve cognitive, affective, and physical functioning. PMID:26256520

  19. Resting and reactive frontal brain electrical activity (EEG among a non-clinical sample of socially anxious adults: Does concurrent depressive mood matter?

    Elliott A Beaton

    2008-03-01

    Full Text Available Elliott A Beaton1, Louis A Schmidt2, Andrea R Ashbaugh2,5, Diane L Santesso2, Martin M Antony1,3,4, Randi E McCabe1,31Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada; 2Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ontario, Canada; 3Anxiety Treatment and Research Centre, St. Joseph’s Healthcare, Hamilton, Ontario, Canada; 4Department of Psychology, Ryerson University, Toronto, Ontario, Canada; 5Concordia University, Montreal, Quebec, CanadaAbstract: A number of studies have noted that the pattern of resting frontal brain electrical activity (EEG is related to individual differences in affective style in healthy infants, children, and adults and some clinical populations when symptoms are reduced or in remission. We measured self-reported trait shyness and sociability, concurrent depressive mood, and frontal brain electrical activity (EEG at rest and in anticipation of a speech task in a non-clinical sample of healthy young adults selected for high and low social anxiety. Although the patterns of resting and reactive frontal EEG asymmetry did not distinguish among individual differences in social anxiety, the pattern of resting frontal EEG asymmetry was related to trait shyness after controlling for concurrent depressive mood. Individuals who reported a higher degree of shyness were likely to exhibit greater relative right frontal EEG activity at rest. However, trait shyness was not related to frontal EEG asymmetry measured during the speech-preparation task, even after controlling for concurrent depressive mood. These findings replicate and extend prior work on resting frontal EEG asymmetry and individual differences in affective style in adults. Findings also highlight the importance of considering concurrent emotional states of participants when examining psychophysiological correlates of personality.Keywords: social anxiety, shyness, sociability, depression, mood, frontal EEG alpha asymmetry

  20. Abnormal brain glucose metabolism and depressive mood in patients with pre-dialytic chronic kidney disease: SPM analysis of F-18 FDG positron emission tomography

    The aim of this study was to investigate the relationship between depressive mood and pre-dialytic CKD, to localize and quantify depressive mood -related lesions in pre-dialytic CKD patients through statistical parametric mapping (SPM) analysis of brain positron emission tomography (PET), and to examine the usefulness of brain PET for early detection and proper treatment of depressive mood. Twenty one patients with stage 5 CKD and 22 healthy volunteers were analyzed by depressive mood assessment and statistical parametric mapping (SPM) analysis of 18F-FDG PET. Depressive mood assessment was done by Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HDRS). The largest clusters were areas including precentral gyrus, prefrontal cortex, and anterior cingulated cortex of left hemisphere. Other clusters were left transverse temporal gyrus, left superior temporal gyrus, right prefrontal cortex, right dorsolateral prefrontal cortex (BA 46, 44), right inferior frontal gyrus, right inferior parietal lobule, left angular gyrus. In addition, correlation was found between hypometabolized areas and HDRS scores of CKD patients in right prefrontal cortex (BA 11) and right anterior cingulated gyrus (BA 24). In conclusion, this study demonstrated specific depressive mood-related abnormal metabolic lesion. Interestingly, in CKD patients with severe depressive mood, cerebral metabolism was similar to that of MDD

  1. Abnormal brain glucose metabolism and depressive mood in patients with pre-dialytic chronic kidney disease: SPM analysis of F-18 FDG positron emission tomography

    Jun, Sung Min; Song, Sang Heon; Kim, Seong Jang; Kim, Ji Hoon; Kwak, Ihm Soo; Kim, In Ju; Kim, Yong Ki [Pusan National University Hospital, Pusan (Korea, Republic of)

    2007-07-01

    The aim of this study was to investigate the relationship between depressive mood and pre-dialytic CKD, to localize and quantify depressive mood -related lesions in pre-dialytic CKD patients through statistical parametric mapping (SPM) analysis of brain positron emission tomography (PET), and to examine the usefulness of brain PET for early detection and proper treatment of depressive mood. Twenty one patients with stage 5 CKD and 22 healthy volunteers were analyzed by depressive mood assessment and statistical parametric mapping (SPM) analysis of 18F-FDG PET. Depressive mood assessment was done by Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HDRS). The largest clusters were areas including precentral gyrus, prefrontal cortex, and anterior cingulated cortex of left hemisphere. Other clusters were left transverse temporal gyrus, left superior temporal gyrus, right prefrontal cortex, right dorsolateral prefrontal cortex (BA 46, 44), right inferior frontal gyrus, right inferior parietal lobule, left angular gyrus. In addition, correlation was found between hypometabolized areas and HDRS scores of CKD patients in right prefrontal cortex (BA 11) and right anterior cingulated gyrus (BA 24). In conclusion, this study demonstrated specific depressive mood-related abnormal metabolic lesion. Interestingly, in CKD patients with severe depressive mood, cerebral metabolism was similar to that of MDD.

  2. Tinnitus Severity Is Reduced with Reduction of Depressive Mood – a Prospective Population Study in Sweden

    Hébert, Sylvie; Canlon, Barbara; Hasson, Dan; Magnusson Hanson, Linda L; Westerlund, Hugo; Theorell, Töres

    2012-01-01

    Tinnitus, the perception of sound without external source, is a highly prevalent public health problem with about 8% of the population having frequently occurring tinnitus, and about 1–2% experiencing significant distress from it. Population studies, as well as studies on self-selected samples, have reported poor psychological well-being in individuals with tinnitus. However, no study has examined the long-term co-variation between mood and tinnitus prevalence or tinnitus severity. In this st...

  3. Mood-Reactive Self-Esteem and Depression Vulnerability: Person-Specific Symptom Dynamics via Smart Phone Assessment

    Clasen, Peter C.; Fisher, Aaron J.; Beevers, Christopher G.

    2015-01-01

    Cognitive theories of depression suggest that mood-reactive self-esteem, a pattern of cognitive reactivity where low self-esteem is temporally dependent on levels of sadness, represents vulnerability for depression. Few studies have directly tested this hypothesis, particularly using intensive data collection methods (i.e., experience sampling) required to capture the temporal dynamics of sadness and self-esteem as they unfold naturally, over time. In this study we used participants’ smartpho...

  4. Association Between Depression and Anxiety in High-Functioning Children with Autism Spectrum Disorders and Maternal Mood Symptoms

    Mazefsky, Carla A; Conner, Caitlin M.; Donald P. Oswald

    2010-01-01

    Research suggests that children with autism spectrum disorders (ASDs) and their relatives have high rates of depression and anxiety. However, relatively few studies have looked at both factors concurrently. This study examined the potential relationship between maternal mood symptoms and depression and anxiety in their children with ASD. Participants were 31 10- to 17-year-old children with an ASD diagnosis that was supported by gold-standard measures and their biological mothers. Mothers com...

  5. Can a One-Item Mood Scale Do the Trick? Predicting Relapse over 5.5-Years in Recurrent Depression

    van Rijsbergen, Gerard D.; Bockting, Claudi L. H.; Berking, Matthias; Koeter, Maarten W. J.; Schene, Aart H

    2012-01-01

    Background To examine whether a simple Visual Analogue Mood Scale (VAMS) is able to predict time to relapse over 5.5-years. Methodology/Principal Findings 187 remitted recurrently depressed out-patients were interviewed using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and the 17-item Hamilton Depression rating scale (HAM-D) to verify remission status (HAM-D

  6. Unequal depression for equal work? How the wage gap explains gendered disparities in mood disorders.

    Platt, Jonathan; Prins, Seth; Bates, Lisa; Keyes, Katherine

    2016-01-01

    Mood disorders, such as depression and anxiety, are more prevalent among women than men. This disparity may be partially due to the effects of structural gender discrimination in the work force, which acts to perpetuate gender differences in opportunities and resources and may manifest as the gender wage gap. We sought to quantify and operationalize the wage gap in order to explain the gender disparity in depression and anxiety disorders, using data from a 2001-2002 US nationally representative survey of 22,581 working adults ages 30-65. Using established Oaxaca-Blinder decomposition methods to account for gender differences in individual-level productivity, our models reduced the wage gap in our sample by 13.5%, from 54% of men's pay to 67.5% of men's pay. We created a propensity-score matched sample of productivity indicators to test if the direction of the wage gap moderated the effects of gender on depression or anxiety. Where female income was less than the matched male counterpart, odds of both disorders were significantly higher among women versus men (major depressive disorder OR: 2.43, 95% CI: 1.95-3.04; generalized anxiety disorder OR: 4.11, 95% CI: 2.80-6.02). Where female income was greater than the matched male, the higher odds ratios for women for both disorders were significantly attenuated (Major Depressive Disorder OR: 1.20; 95% CI: 0.96-1.52) (Generalized Anxiety Disorder OR: 1.5; 95% CI: 1.04-2.29). The test for effect modification by sex and wage gap direction was statistically significant for both disorders. Structural forms of discrimination may explain mental health disparities at the population level. Beyond prohibiting overt gender discrimination, policies must be created to address embedded inequalities in procedures surrounding labor markets and compensation in the workplace. PMID:26689629

  7. Relationship between maternal depression as a risk factor for childhood trauma and mood disorders in young adults

    Luana Porto Barbosa

    2014-07-01

    Full Text Available Background Maternal depression may be a risk factor for childhood trauma (CT, with resultant offspring development of mood disorders (MD in adult life. Objective To verify the relationship between maternal depression (as a risk factor for childhood trauma and mood disorders in young adults. Methods The sample was composed of 164 young adults and their mothers. Maternal depression was identified through the Mini International Neuropsychiatric Interview (M.I.N.I.. Mood Disorders in the young adults were confirmed with the Structured Interview for the DSM-IV (SCID, whereas the CT was evaluated using the Childhood Trauma Questionnaire (CTQ. Results In the group of young adults with MD, individuals who had depressed mothers presented higher mean scores of CT in comparison to the ones who did not have mothers with Depression (p < 0.005. Childhood trauma was also associated with lower social classes (p < 0.005. In the group of young adults without MD, the only variable that was associated with CT was the young adult’s (not current work (p < 0.005. Discussion Maternal depression was considered to be a risk factor for CT and MD in young adults. Thus, preventing and treating maternal psychiatric disorders may diminish the risk of offspring childhood trauma, and, consequently, avoid negative effects in the offspring’s adult life.

  8. Do We Need Both Cognitive and Behavioural Components in Interventions for Depressed Mood in People with Mild Intellectual Disability?

    McGillivray, J. A.; Kershaw, M.

    2015-01-01

    Background: A growing literature suggests that people with mild intellectual disability (ID) who have depressed mood may benefit from cognitive--behavioural interventions. There has been some speculation regarding the relative merit of the components of this approach. The aim of this study was to compare (i) cognitive strategies; (ii) behavioural


  9. Physical Activity Buffers the Effects of Family Conflict on Depressed Mood: A Study on Adolescent Girls and Boys

    Sigfusdottir, Inga Dora; Asgeirsdottir, Bryndis Bjork; Sigurdsson, Jon Fridrik; Gudjonsson, Gisli H.

    2011-01-01

    This paper investigates the relationship between physical activity and depressed mood, under conditions of family conflict. We analyze data from a representative sample of 7232 Icelandic adolescents. Analysis of variance was carried out to test for main and interaction effects. The study shows that while family conflict increases the likelihood of…

  10. A comparison of depressive mood of older adults in a community, nursing homes, and a geriatric hospital: factor analysis of Geriatric Depression Scale.

    Onishi, Joji; Suzuki, Yusuke; Umegaki, Hiroyuki; Endo, Hidetoshi; Kawamura, Takashi; Iguchi, Akihisa

    2006-03-01

    The Geriatric Depression Scale (GDS)-15 was used in 607 adults aged 65+ years living in a community, nursing homes, and a general hospital to explore characteristics of depressive mood in different care settings. Factor analysis of GDS-15 extracted 4 factors labeled unhappiness, apathy and anxiety, loss of hope and morale, and energy loss. The scale scores labeled unhappiness, apathy and anxiety, and loss of hope and morale were negatively correlated with the Barthel Index and the Mini-Mental State Examination scores. The results classified the depressive patterns into 2 types, one fitting the nursing home residents and the other fitting the hospital patients. The dominant factors of the nursing-home type were unhappiness and loss of hope and morale, and the hospital type was highly related with apathy and anxiety. The results indicate an extended utility of the GDS-15 for a deeper understanding of depressive mood in various care settings. PMID:16449757

  11. Alcohol Problems as a Risk Factor for Post-Disaster Depressed Mood among U.S. Veterans

    Heslin, Kevin C.; Stein, Judith A.; Dobalian, Aram; Simon, Barbara; Lanto, Andrew B.; Yano, Elizabeth M.; Rubenstein, Lisa V.

    2012-01-01

    Alcohol problems may impede adaptive, proactive responses to disaster-related injury and loss, thus prolonging the adverse impact of disasters on mental health. Previous work suggests that veterans of the U.S. armed forces have a relatively high prevalence of alcohol misuse and other psychiatric disorders. This is the first study to estimate the impact of pre-disaster alcohol problems on post-disaster depressed mood among veterans, using data that were collected before and after the 1994 Northridge, California earthquake. We assessed the impact of alcohol problems on post-disaster depressed mood in an existing clinical cohort of veterans who experienced the 6.7-magnitude earthquake that struck Northridge in January 1994. One-to-three months after the disaster, interviewers contacted participants by telephone to administer a follow-up questionnaire based on a survey that had been done pre-earthquake. Post-earthquake data were obtained on 1144 male veterans for whom there were pre-earthquake data. We tested a predictive path model of the relationships between latent variables for pre-disaster alcohol problems, functional limitations, and depressed mood on latent variables representing post-disaster “quake impact” and depressive mood. Results showed that veterans who had more alcohol problems before the earthquake experienced more earthquake-related harms and severely depressed mood after the earthquake, compared with those who had fewer alcohol problems. Programs serving veterans with a high prevalence of alcohol problems should consider designing disaster response protocols to locate and assist these patients in the aftermath of disasters. PMID:23106638

  12. Depression, Schizophrenia, and Social Attraction.

    Boswell, Philip C.; Murray, Edward J.

    1981-01-01

    Compared the dysphoric mood induction and attraction that subjects reported after a vicarious experience with a depressed patient and a comparable experience with a schizophrenic patient. Results showed similar arousal of dysphoric mood and rejection for both patients. (RC)

  13. IRRITABLE MOOD IN ADULT MAJOR DEPRESSIVE DISORDER: RESULTS FROM THE WORLD MENTAL HEALTH SURVEYS

    Kovess-Masfety, Viviane; Alonso, Jordi; Angermeyer, Matthias; Bromet, Evelyn; de Girolamo, Giovanni; de Jonge, Peter; Demyttenaere, Koen; Florescu, Silvia E.; Gruber, Michael J.; Gureje, Oye; Hu, Chiyi; Huang, Yueqin; Karam, Elie G.; Jin, Robert; LĂ©pine, Jean-Pierre; Levinson, Daphna; McLaughlin, Katie A.; Medina-Mora, MarĂ­a E.; O’Neill, Siobhan; Ono, Yutaka; Posada-Villa, JosĂ© A.; Sampson, Nancy A.; Scott, Kate M.; Shahly, Victoria; Stein, Dan J.; Viana, Maria C.; Zarkov, Zahari; Kessler, Ronald C.

    2014-01-01

    Background Although irritability is a core symptom of DSM-IV major depressive disorder (MDD) for youth but not adults, clinical studies find comparable rates of irritability between nonbipolar depressed adults and youth. Including irritability as a core symptom of adult MDD would allow detection of depression-equivalent syndromes with primary irritability hypothesized to be more common among males than females. We carried out a preliminary examination of this issue using cross-national community-based survey data from 21 countries in the World Mental Health (WMH) Surveys (n = 110,729). Methods The assessment of MDD in the WHO Composite International Diagnostic Interview includes one question about persistent irritability. We examined two expansions of the definition of MDD involving this question: (1) cases with dysphoria and/or anhedonia and exactly four of nine Criterion A symptoms plus irritability; and (2) cases with two or more weeks of irritability plus four or more other Criterion A MDD symptoms in the absence of dysphoria or anhedonia. Results Adding irritability as a tenth Criterion A symptom increased lifetime prevalence by 0.4% (from 11.2 to 11.6%). Adding episodes of persistent irritability increased prevalence by an additional 0.2%. Proportional prevalence increases were significantly higher, but nonetheless small, among males compared to females. Rates of severe role impairment were significantly lower among respondents with this irritable depression who did not meet conventional DSM-IV criteria than those with DSM-IV MDD. Conclusion Although limited by the superficial assessment in this single question on irritability, results do not support expanding adult MDD criteria to include irritable mood. PMID:23364997

  14. Brief Report: The Factor Structure of Mood States in an Early Adolescent Sample

    Duffy, Christopher J.; Cunningham, Everarda G.; Moore, Susan M.

    2005-01-01

    The purpose of this study was to examine the structure of negative mood states among young adolescents. Students (N=216) aged 11-15 years from a secondary school in Melbourne, Australia, completed the Depression, Anxiety, Stress Scales (DASS) [Lovibond, S. H., & Lovibond, P. F. (1996). "Depression anxiety stress scales." Sydney: The Psychology


  15. Prevalence, stability, 1-year incidence and predictors of depressive symptoms among Norwegian adolescents in the general population as measured by the Short Mood and Feelings Questionnaire.

    Larsson, Bo; Ingul, JoMagne; Jozefiak, Thomas; Leikanger, Einar; Sund, Anne Mari

    2016-05-01

    Background In numerous surveys the prevalence of depressive symptoms in adolescents has been examined in single sites and at one time point. Aims We examined depressive symptoms among adolescents aged 10-19 years in four different large school samples including two cohorts over a 10-year period in different locations in the same health region in central Norway including a total of 5804 adolescents. Two cohorts were retested within a 1-year time period to predict high versus low depressive symptom scores. Changes over a 6-year period in depressive symptom levels were examined in two of the samples of 12-14-year olds. Methods Depressive symptoms were estimated by the 13-item Short Mood and Feelings Questionnaire (SMFQ). Covariates were student age, sex, school size and location. Results "Miserable or unhappy", "Tired", "Restlessness" and "Poor concentration" were the most commonly reported depressive symptoms. Depressive symptom levels and proportions of high scoring students were consistently higher among girls, in particular in mid and late adolescence. Poisson regression analysis showed that all SMFQ items significantly predicted total scores for the whole sample, while sex (girls having a higher risk) emerged as a consistent 1-year predictor of high depressive symptom levels. Conclusions The SMFQ constitutes a short, practical and feasible measure. We recommend that this standardized measure should be used in the assessment of depressive symptoms among adolescents in school, primary care and clinical settings but also to evaluate treatment outcome. High scorers should be evaluated in subsequent clinical interviews for the presence of a depressive disorder. PMID:26817811

  16. Usefulness of the Spanish version of the mood disorder questionnaire for screening bipolar disorder in routine clinical practice in outpatients with major depression

    Montes José

    2008-05-01

    Full Text Available Abstract Background According to some studies, almost 40% of depressive patients – half of them previously undetected – are diagnosed of bipolar II disorder when systematically assessed for hypomania. Thus, instruments for bipolar disorder screening are needed. The Mood Disorder Questionnaire (MDQ is a self-reported questionnaire validated in Spanish in stable patients with a previously known diagnosis. The purpose of this study is to evaluate in the daily clinical practice the usefulness of the Spanish version of the MDQ in depressive patients. Methods Patients (n = 87 meeting DSM-IV-TR criteria for a major depressive episode, not previously known as bipolar were included. The affective module of the Structured Clinical Interview (SCID was used as gold standard. Results MDQ screened 24.1% of depressive patients as bipolar, vs. 12.6% according to SCID. For a cut-off point score of 7 positive answers, sensitivity was 72.7% (95% CI = 63.3 – 82.1 and specificity 82.9% (95% CI = 74.9–90.9. Likelihood ratio of positive and negative tests were 4,252 y 0,329 respectively. Limitations The small sample size reduced the power of the study to 62%. Conclusion Sensitivity and specificity of the MDQ were high for screening bipolar disorder in patients with major depression, and similar to the figures obtained in stable patients. This study confirms that MDQ is a useful instrument in the daily clinical assessment of depressive patients.

  17. Gender disparities of depressive mood and roles of family factors, school difficulty, violence, and unhealthy behaviours among adolescents

    Chau, KĂ©nora; Baumann, MichĂšle

    2012-01-01

    Nowadays modern societies are to be more competitive and include more non-intact families and living difficulties due to employment and social deprivations. Adolescents may suffer from depressive mood (DM) which is common and multi-factorial. This study assessed, among boys and girls, the causal relationships between DM and parent education, nationality, occupation, income, divorce/separation, and death, repeating a school-year, lifetime alcohol/tobacco/cannabis/other drugs use...

  18. The impact of daily stress on adolescents' depressed mood: The role of social support seeking through Facebook

    Frison, Eline; Eggermont, Steven

    2015-01-01

    This study examined relationships among daily stress (i.e., school- and family-related stress), social support seeking through Facebook, perceived social support through Facebook, and depressed mood among adolescents (N = 910). Structural equation modeling showed that daily stress positively predicted adolescents’ seeking of social support through Facebook. In addition, when social support was sought on Facebook and subsequently perceived, social support seeking through Facebook decreased a...

  19. Depressive mood, bonding failure, and abusive parenting among mothers with three-month-old babies in a Japanese community

    Toshinori Kitamura; Yukiko Ohashi; Sachiko Kita; Megumi Haruna; Reiko Kubo

    2013-01-01

    Objective: To investigate the relationships between depressive mood, bonding failure, and abusive parenting. Method: We distributed questionnaires to 1198 mothers attending a three-month postnatal health check-up in rural areas in Japan. The questionnaires assessed these three variables along with demographics. We evaluated the causal relationships by comparing different structural equation models to the data. Results: Although all the models fit the data well, the best Akaike Information Cr...

  20. Kleptomania, mood disorder and lithium

    Fábio Lopes Rocha; Maria Elizabete Guimarăes Rocha

    1992-01-01

    Kleptomania has been found in association with major depression in a fairly large number of reports in recent years. We describe a patient with concurrent DSM-III-R Bipolar Mood Disorder and Kleptomania, whose symptoms remitted completely, apparently in response to lithium therapy, which raised the possibility that pharmacological treatment may benefit kleptomania. Further studies are needed to establish the possible relationship between kleptomania, mood disorders and lithium therapy.

  1. Kleptomania, mood disorder and lithium

    FĂĄbio Lopes Rocha

    1992-12-01

    Full Text Available Kleptomania has been found in association with major depression in a fairly large number of reports in recent years. We describe a patient with concurrent DSM-III-R Bipolar Mood Disorder and Kleptomania, whose symptoms remitted completely, apparently in response to lithium therapy, which raised the possibility that pharmacological treatment may benefit kleptomania. Further studies are needed to establish the possible relationship between kleptomania, mood disorders and lithium therapy.

  2. Correlations between regional cerebral blood flow and depression scale in the mood disorder. A study using 123I-IMP SPECT

    Regional cerebral blood flow (rCBF) was assessed on 26 mood disorder patients using 123I-iodoamphetamine and single photon emission computed tomography (SPECT), and their correlations to depression scores of Hamilton's Rating Scale for Depression were studied. Region of interest (ROI) was established on coronary images and used as an indicator. As a result, left hemisphere was suspected of a primary lesion in mood disorder, however, the relationship between clinical symptoms and various lesion areas were not clarified. Further studies with neuropsychological loading or pharmaceutical loading such as antidepressant are thus expected to clarify the etiology of mood disorders. (S.Y.)

  3. Internet-Based Recruitment to a Depression Prevention Intervention: Lessons From the Mood Memos Study

    Morgan, Amy Joanna; Jorm, Anthony Francis; Mackinnon, Andrew James

    2013-01-01

    Background Recruiting participants to randomized controlled trials of health interventions can be very difficult. Internet-based recruitment is becoming an increasingly important mode of recruitment, yet there are few detailed accounts of experiences recruiting participants to mental health interventions. Objective To report on our experience with Internet-based recruitment to an online depression prevention intervention and pass on lessons we learned. Methods Participants were recruited to t...

  4. Prevalence of mood and anxiety disorder in self reported irritable bowel syndrome (IBS. An epidemiological population based study of women

    Mykletun Arnstein

    2010-08-01

    Full Text Available Abstract Background Irritable bowel syndrome (IBS is commonly regarded as a functional disorder, and is hypothesized to be associated with anxiety and depression. This evidence mainly rests on population-based studies utilising self-report screening instruments for psychopathology. Other studies applying structured clinical interviews are generally based on small clinical samples, which are vulnerable to biases. The extant evidence base for an association between IBS and psychopathology is hence not conclusive. The aim of this study was therefore to re-examine the hypothesis using population-based data and psychiatric morbidity established with a structured clinical interview. Methods Data were derived from a population-based epidemiological study (n = 1077. Anxiety and mood disorders were established using the Structured Clinical Interview for DSM-IV-TR (SCID-I/NP and the General Health Questionnaire (GHQ-12. Current and lifetime IBS was self-reported. Hypertension and diabetes were employed as comparison groups as they are expected to be unrelated to mental health. Results Current IBS (n = 69, 6.4% was associated with an increased likelihood of current mood and/or anxiety disorders (OR = 2.62, 95%CI 1.49 - 4.60. Half the population reporting a lifetime IBS diagnosis also had a lifetime mood or anxiety disorder. Exploratory analyses demonstrated an increased prevalence of IBS across most common anxiety and mood disorders, the exception being bipolar disorder. The association with IBS and symptoms load (GHQ-12 followed a curved dose response pattern. In contrast, hypertension and diabetes were consistently unrelated to psychiatric morbidity. Conclusions IBS is significantly associated with anxiety and mood disorders. This study provides indicative evidence for IBS as a disorder with a psychosomatic aspect.

  5. The Relationship between ADHD Symptoms, Mood Instability, and Self-Reported Offending

    Gudjonsson, Gisli H.; Sigurdsson, Jon Fridrik; Adalsteinsson, Tomas F.; Young, Susan

    2013-01-01

    Objective: To investigate the relative importance of ADHD symptoms, mood instability, and antisocial personality disorder traits in predicting self-reported offending. Method: A total of 295 Icelandic students completed two scales of offending behavior and measures of ADHD symptoms, mood instability, and antisocial personality traits. Results:


  6. The Relationship between ADHD Symptoms, Mood Instability, and Self-Reported Offending

    Gudjonsson, Gisli H.; Sigurdsson, Jon Fridrik; Adalsteinsson, Tomas F.; Young, Susan

    2013-01-01

    Objective: To investigate the relative importance of ADHD symptoms, mood instability, and antisocial personality disorder traits in predicting self-reported offending. Method: A total of 295 Icelandic students completed two scales of offending behavior and measures of ADHD symptoms, mood instability, and antisocial personality traits. Results:…

  7. Prospective and Retrospective Reports of Mood States before Relapse to Substance Abuse.

    Hodgins, David C.; And Others

    1995-01-01

    Examines the role of mood in precipitating relapses among alcohol-dependent participants from both a retrospective and predictive point of view. Support was found for a relationship between negative bias and the amount of negative mood assessed at the time the report was given. As previously found, the most frequent precipitant of relapses and


  8. Efficacy of pain treatment on mood syndrome in patients with dementia: a randomized clinical trial

    Husebű, Bettina Sandgathe; Ballard, Clive; Fritze, Friederike; Sandvik, Reidun Karin; Aarsland, Dag

    2014-01-01

    Background: Depression is common in nursing home (NH) patients with dementia, and often clustered with anxiety and other mood symptoms. An association between pain and depressive symptoms has been reported, but the impact of pain management on depression and other mood symptoms has not been investigated.

    Objective: Secondary analyses of a cluster randomized clinical trial examine the response of dementia-related mood symptoms to a Stepwise Protocol of Treating Pain.

  9. Internet Cognitive Behavioral Therapy for Women With Postnatal Depression: A Randomized Controlled Trial of MumMoodBooster

    Milgrom, Jeannette; Danaher, Brian G; Holt, Charlene; Holt, Christopher J; Seeley, John R; Tyler, Milagra S; Ross, Jessica; Ericksen, Jennifer

    2016-01-01

    Background There are few published controlled trials examining the efficacy of Internet-based treatment for postnatal depression (PND) and none that assess diagnostic status (clinical remission) as the primary outcome. This is despite the need to improve treatment uptake and accessibility because fewer than 50% of postnatally depressed women seek help, even when identified as depressed. Objective In a randomized controlled trial (RCT), we aimed to test the efficacy of a 6-session Internet intervention (the MumMoodBooster program, previously evaluated in a feasibility trial) in a sample of postnatal women with a clinical diagnosis of depression. The MumMoodBooster program is a cognitive behavioral therapy (CBT) intervention, is highly interactive, includes a partner website, and was supported by low-intensity telephone coaching. Methods This was a parallel 2-group RCT (N=43) comparing the Internet CBT treatment (n=21) to treatment as usual (n=22). At baseline and at 12 weeks after enrollment, women’s diagnostic status was assessed by telephone with the Standardized Clinical Interview for DSM-IV (SCID-IV) and symptom severity with the Beck Depression Inventory (BDI-II). Depression symptoms were measured repeatedly throughout the study period with the Patient Health Questionnaire (PHQ-9). Results At the end of the study, 79% (15/19) of women who received the Internet CBT treatment no longer met diagnostic criteria for depression on the SCID-IV (these outcome data were missing for 2 intervention participants). This contrasted with only 18% (4/22) remission in the treatment as usual condition. Depression scores on the BDI-II showed a large effect favoring the intervention group (d=.83, 95% CI 0.20-1.45). Small to medium effects were found on the PHQ-9 and on measures of anxiety and stress. Adherence to the program was very good with 86% (18/21) of users completing all sessions; satisfaction with the program was rated 3.1 out of 4 on average. Conclusions Our results suggest that our Internet CBT program, MumMoodBooster, is an effective treatment option for women clinically diagnosed with PND. This is one of only two controlled evaluations of specialized online psychological treatment among women clinically diagnosed with PND. MumMoodBooster appears to be a feasible, effective treatment option, which is potentially accessible to large numbers of women in metropolitan, rural, and remote areas. Future work might be focused profitably on establishing comparability with face-to-face treatments and purely self-guided delivery. We have commenced a larger RCT comparing MumMoodBooster with face-to-face CBT. Trial Registration Australian and New Zealand Clinical Trials Registry (ANZCTR): ACTRN12613000113752; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=363561 (Archived by WebCite¼ at http://www.webcitation.org/6f64kuyLf). PMID:26952645

  10. About Mood Disorders

    ... experience ups and downs during their lives, those living with depression experience specific symptoms daily for two weeks or ... DBSA envisions wellness for people who live with depression and bipolar disorder. ... living with mood disorders, our vision, mission, and programming ...

  11. Evidence against mood-congruent attentional bias in Major Depressive Disorder.

    Cheng, Philip; Preston, Stephanie D; Jonides, John; Mohr, Alicia Hofelich; Thummala, Kirti; Casement, Melynda; Hsing, Courtney; Deldin, Patricia J

    2015-12-15

    Depression is consistently associated with biased retrieval and interpretation of affective stimuli, but evidence for depressive bias in earlier cognitive processing, such as attention, is mixed. In five separate experiments, individuals with depression (three experiments with clinically diagnosed major depression, two experiments with dysphoria measured via the Beck Depression Inventory) completed three tasks designed to elicit depressive biases in attention, including selective attention, attentional switching, and attentional inhibition. Selective attention was measured using a modified emotional Stroop task, while attentional switching and inhibition was examined via an emotional task-switching paradigm and an emotional counter task. Results across five different experiments indicate that individuals with depression perform comparably with healthy controls, providing corroboration that depression is not characterized by biases in attentional processes. PMID:26477954

  12. Does depression screening have an effect on the diagnosis and treatment of mood disorders in general medical settings?: an instrumental variable analysis of the national ambulatory medical care survey.

    Mojtabai, Ramin

    2011-08-01

    This study examined the association of depression screening with the diagnoses of mood disorders and prescription of antidepressants in 73,712 visits to nonpsychiatrist physician offices drawn from the 2005-2007 U.S. National Ambulatory Medical Care Survey. Physicians used depression screening selectively for patients whom they perceived as more likely to have a mood disorder. In bivariate probit analyses with instrumental variables, depression screening did not increase the prevalence of either mood disorder diagnoses or prescription of antidepressants. However, screening was associated with lower rates of antidepressants prescription without a diagnosis of a mood disorder. In visits in which antidepressants were prescribed, 47.4% of the screened visits compared with 16.3% of nonscreened visits had a mood disorder diagnosis. As currently practiced in medical settings, depression screening may help improve targeting and appropriate use of antidepressant medications. Wider use of depression screening may help curb the growing trend of off-label antidepressant prescriptions. PMID:21454246

  13. Locus of Control, Self-Reported Depression, and Perceived Causes of Depression

    Calhoun, Lawrence G.; And Others

    1974-01-01

    Examines the relation of depression to locus of control and to the perceived causes of depression in a nonpsychiatric population. Findings suggest that adolescent females tend to hold themselves more responsible than males for unsatisfactory personal situations, and this extends to the attribution of causes for unhappy moods. (Author/PC)

  14. Poor quality of life, depressed mood, and memory impairment may be mediated by sleep disruption in patients with Addison's disease

    Henry, Michelle; Wolf, Pedro S. A.; Ian L. Ross; Thomas, Kevin G. F.

    2015-01-01

    Standard replacement therapy for Addison's disease (AD) does not restore a normal circadian rhythm. In fact, hydrocortisone replacement in AD patients likely induces disrupted sleep. Given that healthy sleep plays an important role in improving quality of life, optimizing cognition, and ensuring affect regulation, the aim of this study was to investigate whether poor quality of life, mood alterations, and memory complaints reported by AD patients are associated with their disrupted sleep patt...

  15. Major depressive disorder in an adolescent with Turner syndrome: a case report.

    Mao, Shujiong; Sun, Liying; Li, Rong; Zhao, Zhengyan; Yang, Rongwang

    2016-05-01

    Turner syndrome (TS) is a chromosomal abnormality, of which the presence and impact of coexisting psychiatric morbidity has received little attention. The present report describes an adolescent with mosaic karyotype TS who had major depressive disorder with the predisposing cause of psychosocial burden, and relieved with the treatment of sertraline and complete remission with combined use of estradiol valerate. The report suggests us to pay more attention on the mood disorders in children with TS, especially in adolescents. For treatment aspect, medications for improving the puberty development and short stature should be added to in addition to antidepressants if they had mood disorders. PMID:26698832

  16. Continuity and Discontinuity of Depressed Mood from Late Adolescence to Young Adulthood: The Mediating and Stabilizing Roles of Young Adults' Socioeconomic Attainment

    Wickrama, K. A. S.; Conger, Rand D.; Lorenz, Federick O.; Martin, Monica

    2012-01-01

    Using prospective, longitudinal data from 467 youth over a 13-year period (late adolescence and young adulthood), the present study investigates three research questions: (1) to what extent do elevations in depressed mood continue (homotypic continuity) from adolescence to young adulthood, (2) to what extent do young adults' socioeconomic…

  17. Postpartum Depression

    ... shifts affect the brain's mood chemistry in a way that can lead to sadness, low mood, and depression that lingers. Stress hormones may have an added effect on mood. Some women might experience this more than others. When to ...

  18. Chronobiology and Mood Disorders

    Yavuz Selvi

    2011-09-01

    Full Text Available Living organizms show cyclic rhythmicity in a variety of physiological, hormonal, behavioral, and psychological processes. Sleep-wake cycles, body temperature, hormone levels, mood and cognition display a circadian rhythm in humans. Delays, advances or desynchronizations of circadian rhythm are known to be strongly associated with mental illness especially mood disorders such as bipolar disorder, major depression and seasonal affective disorder. Furthermore, some of the mood stabilizers, sleep deprivation and light treatment are employed to treat mood disorders by shifting circadian rhythm. This paper reviews the relationship between mood disorders and circadian rhythm, and describes treatment options by altering circadian rhythm.

  19. Impact of group music therapy on the depression mood of college students

    Haizhen Wang; Jinliang Wang; Dajun Zhang

    2011-01-01

    The goal of this study was to examine the effects of group music therapy on depression and mental health among college students. 80 students participated in this study, with 40 assigned to control group and other 40 assigned to experimental group. The results showed that after the group music therapy, for the experimental group, the depression scores have reduced significantly and the mental health scores have improved, while for the control group, no significant difference was obtained on th...

  20. Yoga as a Complementary Treatment of Depression: Effects of Traits and Moods on Treatment Outcome

    Michelle Abrams; Cristina Ottaviani; Leuchter, Andrew F.; Davydov, Dmitry M.; Cook, Ian A.; David Shapiro

    2007-01-01

    Preliminary findings support the potential of yoga as a complementary treatment of depressed patients who are taking anti-depressant medications but who are only in partial remission. The purpose of this article is to present further data on the intervention, focusing on individual differences in psychological, emotional and biological processes affecting treatment outcome. Twenty-seven women and 10 men were enrolled in the study, of whom 17 completed the intervention and pre- and post-interv...

  1. Statistical parametric mapping analysis of the relationship between regional cerebral blood flow and symptom clusters of the depressive mood in patients with pre-dialytic chronic kidney disease

    The aim of this study is to investigate the relationship between regional cerebral blood flow (rCBF) and symptom clusters of depressive mood in pre-dialytic chronic kidney disease (CKD). Twenty-seven patients with stage 4-5 CKD were subjected to statistical parametric mapping analysis of brain single-photon emission computed tomography. Correlation analyses between separate symptom clusters of depressive mood and rCBF were done. The first factor (depressive mood) was negatively correlated with rCBF in the right insula, posterior cingulate gyrus, and left superior temporal gyrus, and positively correlated with rCBF in the left fusiform gyrus. The second factor (insomnia) was negatively correlated with rCBF in the right middle frontal gyrus, bilateral cingulate gyri, right insula, right putamen, and right inferior parietal lobule, and positively correlated with rCBF in left fusiform gyrus and bilateral cerebellar tonsils. The third factor (anxiety and psychomotor aspects) was negatively correlated with rCBF in the left inferior frontal gyms, right superior frontal gyms, right middle temporal gyrus, right superior temporal gyrus, and left superior frontal gyrus, and positively correlated with rCBF in the right ligual gyrus and right parahippocampal gyrus. In this study, the separate symptom clusters were correlated with specific rCBF patterns similar to those in major depressive disorder patients without CKD. However, some areas with discordant rCBF patterns were also noted when compared with major depressive disorder patients. Further larger scale investigations are needed. (author)

  2. Measuring Positive Emotion With the Mood and Anxiety Symptom Questionnaire: Psychometric Properties of the Anhedonic Depression Scale.

    Kendall, Ashley D; Zinbarg, Richard E; Bobova, Lyuba; Mineka, Susan; Revelle, William; Prenoveau, Jason M; Craske, Michelle G

    2016-02-01

    Low positive emotion distinguishes depression from most types of anxiety. Formative work in this area employed the Anhedonic Depression scale from the Mood and Anxiety Symptom Questionnaire (MASQ-AD), and the MASQ-AD has since become a popular measure of positive emotion, often used independently of the full MASQ. However, two key assumptions about the MASQ-AD-that it should be represented by a total scale score, and that it measures time-variant experiences-have not been adequately tested. The present study factor analyzed MASQ-AD data collected annually over 3 years (n = 618, mean age = 17 years at baseline), and then decomposed its stable and unstable components. The results suggested the data were best represented by a hierarchical structure, and that less than one quarter of the variance in the general factor fluctuated over time. The implications for interpreting past findings from the MASQ-AD, and for conducting future research with the scale, are discussed. PMID:25657305

  3. Prefrontal Electrical Stimulation in Non-depressed Reduces Levels of Reported Negative Affects from Daily Stressors

    Austin, Adelaide; Jiga-Boy, Gabriela M.; Rea, Sara; Newstead, Simon A.; Roderick, Sian; Davis, Nick J.; Clement, R. Marc; Boy, Frédéric

    2016-01-01

    Negative emotional responses to the daily life stresses have cumulative effects which, in turn, impose wide-ranging negative constraints on emotional well being and neurocognitive performance (Kalueff and Nutt, 2007; Nadler et al., 2010; Charles et al., 2013). Crucial cognitive functions such as memory and problem solving, as well more short term emotional responses (e.g., anticipation of- and response to- monetary rewards or losses) are influenced by mood. The negative impact of these behavioral responses is felt at the individual level, but it also imposes major economic burden on modern healthcare systems. Although much research has been undertaken to understand the underlying mechanisms of depressed mood and design efficient treatment pathways, comparatively little was done to characterize mood modulations that remain within the boundaries of a healthy mental functioning. In one placebo-controlled experiment, we applied daily prefrontal transcranial Direct Current Stimulation (tDCS) at five points in time, and found reliable improvements on self-reported mood evaluation. Using a new team of experimenters, we replicated this finding in an independent double-blinded placebo-controlled experiment and showed that stimulation over a shorter period of time (3 days) is sufficient to create detectable mood improvements. Taken together, our data show that repeated bilateral prefrontal tDCS can reduce psychological distress in non-depressed individuals. PMID:26973591

  4. Epigenetics in mood disorders.

    McGowan, Patrick O; Kato, Tadafumi

    2008-01-01

    Depression develops as an interaction between stress and an individual's vulnerability to stress. The effect of early life stress and a gene-environment interaction may play a role in the development of stress vulnerability as a risk factor for depression. The epigenetic regulation of the promoter of the glucocorticoid receptor gene has been suggested as a molecular basis of such stress vulnerability. It has also been suggested that antidepressive treatment, such as antidepressant medication and electroconvulsive therapy, may be mediated by histone modification on the promoter of the brain-derived neurotrophic factor gene. Clinical genetic studies in bipolar disorder suggest the role of genomic imprinting, although no direct molecular evidence of this has been reported. The role of DNA methylation in mood regulation is indicated by the antimanic effect of valproate, a histone deacetylase inhibitor, and the antidepressive effect of S-adenosyl methionine, a methyl donor in DNA methylation. Studies of postmortem brains of patients have implicated altered DNA meA methylation of the promoter region of membrane-bound catechol-O-methyltransferase in bipolar disorder. An altered DNA methylation status of PPIEL (peptidylprolyl isomerase E-like) was found in a pair of monozygotic twins discordant for bipolar disorder. Hypomethylation of PPIEL was also found in patients with bipolar II disorder in a case control analysis. These fragmentary findings suggest the possible role of epigenetics in mood disorders. Further studies of epigenetics in mood disorders are warranted. PMID:19568875

  5. Help4Mood: a computational distributed system to support the treatment of patients with major depression

    Pérez Díaz de Cerio, David; Valenzuela Gonzålez, José Luis; Ruiz Boqué, Sílvia; García Lozano, Mario; Colomé, Josep Maria

    2011-01-01

    A closed loop approach supporting the control, communication and treatment management of patients with Major Depression is presented, based on a distributed system with three main components: a Personal Monitoring System, a Virtual Agent component and the Decision Support System for Treatment Management. In this paper an explanation of the main concepts related with Remote Personal Monitoring and Patient Interaction that have been adopted in the project is given, with special emph...

  6. MomMoodBooster Web-Based Intervention for Postpartum Depression: Feasibility Trial Results

    Danaher, Brian G; Milgrom, Jeannette; Seeley, John R; STUART, SCOTT; Schembri, Charlene; Tyler, Milagra S.; Ericksen, Jennifer; Lester, Whitney; Gemmill, Alan W; Kosty, Derek B; LEWINSOHN, PETER

    2013-01-01

    Background Postpartum depression (PPD)—the most common complication of childbirth—is a significant and prevalent public health problem that severely disrupts family interactions and can result in serious lasting consequences to the health of women and the healthy development of infants. These consequences increase in severity when left untreated; most women with PPD do not obtain help due to a range of logistical and attitudinal barriers. Objective This pilot study was designed to test the fe...

  7. A proof of principle for using adaptive testing in routine Outcome Monitoring: the efficiency of the Mood and Anxiety Symptoms Questionnaire -Anhedonic Depression CAT

    Smits Niels; Zitman Frans G; Cuijpers Pim; den Hollander-Gijsman Margien E; Carlier Ingrid VE

    2012-01-01

    Abstract Background In Routine Outcome Monitoring (ROM) there is a high demand for short assessments. Computerized Adaptive Testing (CAT) is a promising method for efficient assessment. In this article, the efficiency of a CAT version of the Mood and Anxiety Symptom Questionnaire, - Anhedonic Depression scale (MASQ-AD) for use in ROM was scrutinized in a simulation study. Methods The responses of a large sample of patients (N = 3,597) obtained through ROM were used. The psychometric evaluatio...

  8. Paternal postpartum mood: bipolar episodes? DepressĂŁo paterna: episĂłdio bipolar?

    Karen Amaral Tavares Pinheiro

    2011-09-01

    Full Text Available OBJECTIVE: We describe the prevalence of depressive and bipolar spectrum episodes in fathers in antenatal and postnatal periods, as well as at 12 months after childbirth. METHOD: A longitudinal follow-up study was conducted with a representative sample of 739 fathers whose children were born between April 2007 and May 2008 in maternity wards in the city of Pelotas, southern Brazil. Paternal psychopathology was measured with the Mini Neuropsychiatric Interview (MINI across three time points: between 28 and 34 weeks of pregnancy (T1, 30 to 60 days postpartum (T2, and 12 months after childbirth (T3. RESULTS: The prevalence of depressive episodes was 5.0% at T1, 4.5% at T2, and 4.3% at T3. Mixed episodes were present in 3%, 1.7%, and 0.9% of subjects, respectively, and accounted for 61.1% of the cases of depression in the antenatal period, 37.5% in postpartum, and 21.4% at 12 months. Depressive and manic/hypomanic episodes were significantly associated during pregnancy and in postpartum, but not at 12 months after childbirth. CONCLUSION: Bipolar episodes were common in men with depressive symptoms during their partner's pregnancy in the postpartum period and, to a lesser extent, 12 months after childbirth. Therefore, this population should be carefully investigated for manic and hypomanic symptoms.OBJETIVO: Verificar a prevalĂȘncia dos episĂłdios depressivos e bipolares em homens no perĂ­odo prĂ© e pĂłs-natal, assim como 12 meses apĂłs o parto. MÉTODO: Estudo longitudinal com amostra de pais cujas crianças nasceram entre abril de 2007 e maio de 2008 em maternidades da cidade de Pelotas-RS, no sul do Brasil. EpisĂłdios depressivos e manĂ­acos/hipomanĂ­acos foram mensurados com o Mini Neuropsychiatric Interview em trĂȘs tempos diferentes: entre a 28ÂȘ e 34ÂȘ semanas de gestação (T1, 30 a 60 dias apĂłs o parto (T2 e 12 meses apĂłs o nascimento da criança. RESULTADOS: A prevalĂȘncia de episĂłdios depressivos foi 5,0% em T1, 4,5% em T2 e 4,3% em T3. EpisĂłdios mistos estiveram presentes em 3,0, 1,7 e 0,9%, respectivamente, e somaram 61,1% de casos de depressĂŁo antenatal, 37,5% pĂłs-natal e 21,4% aos 12 meses pĂłs-parto. EpisĂłdio depressivo e manĂ­aco/hipomanĂ­aco esteve significativamente associado durante a gestação e o pĂłs-parto. CONCLUSÃO: EpisĂłdios bipolares sĂŁo comuns em homens com sintomas depressivos durante a gestação de suas companheiras e no perĂ­odo pĂłs-natal. Essa população deveria ser cuidadosamente investigada para sintomas manĂ­acos e hipomanĂ­acos, a fim de ser adequadamente tratada.

  9. Condiçőes ambientais associadas ao humor depressivo na adolescência / Environmental conditions associated with depressed mood in adolescence

    Anabela, Rosando; Margarida Gaspar de, Matos.

    2013-03-01

    Full Text Available O presente trabalho analisa a associaçăo entre ambiente físico e social e a psicopatologia, nomeadamente depressăo, numa amostra de 254 adolescentes, 82 do sexo masculino e 172 do sexo feminino, todos estudantes do ensino secundário de três escolas de uma zona perto de Lisboa, com uma média de idade [...] de 16,9 (DP = 1,48). A recolha de dados foi efetuada com recurso a um Questionário Demográfico, ao Inventário de Depressăo Infantil - CDI (Kovacs, 1981) e ao Inventário de Sintomas Breve - BSI (Derogatis, 1982). Os resultados confirmaram a hipótese de uma associaçăo entre sexo, grau de escolaridade, a ESE parental e as condiçőes ambientais da habitaçăo e do bairro. As implicaçőes dos resultados săo discutidas sobre os esforços para aumentar a prevençăo de bem-estar e saúde mental durante a adolescência. Abstract in english The present work analyse the association of the social and physical environment and the psychopathology, namely depression, in a sample of 254 teenagers, 82 males and 172 females, all them high school students from three schools nearby area of Lisbon, with a average age of 16.9 (SD = 1.48). The data [...] collection included a Demographic Questionnaire, the ChildrenŽs Depression Inventory - CDI (Kovacs, 1981) and the Brief Symptom Inventory - BSI (Derogatis, 1982). Results confirmed the hypothesis of an association among gender, school grade, parental SES and the environmental conditions of the housing and neighbourhood. Implications of the results are discussed namely concerning preventing efforts to increase wellbeing and mental health during adolescence.

  10. Ecological momentary assessment versus standard assessment instruments for measuring mindfulness, depressed mood, and anxiety among older adults.

    Moore, RC; Depp, CA; Wetherell, JL; Lenze, EJ

    2016-01-01

    As mobile data capture tools for patient-reported outcomes proliferate in clinical research, a key dimension of measure performance is sensitivity to change. This study compared performance of patient-reported measures of mindfulness, depression, and anxiety symptoms using traditional paper-and-pencil forms versus real-time, ambulatory measurement of symptoms via ecological momentary assessment (EMA). Sixty-seven emotionally distressed older adults completed paper-and-pencil measures of mindf...

  11. Ecological momentary assessment versus standard assessment instruments for measuring mindfulness, depressed mood, and anxiety among older adults.

    Moore, Raeanne C; Depp, Colin A; Wetherell, Julie Loebach; Lenze, Eric J

    2016-04-01

    As mobile data capture tools for patient-reported outcomes proliferate in clinical research, a key dimension of measure performance is sensitivity to change. This study compared performance of patient-reported measures of mindfulness, depression, and anxiety symptoms using traditional paper-and-pencil forms versus real-time, ambulatory measurement of symptoms via ecological momentary assessment (EMA). Sixty-seven emotionally distressed older adults completed paper-and-pencil measures of mindfulness, depression, and anxiety along with two weeks of identical items reported during ambulatory monitoring via EMA before and after participation in a randomized trial of Mindfulness-Based Stress Reduction (MBSR) or a health education intervention. We calculated effect sizes for these measures across both measurement approaches and estimated the Number-Needed-to-Treat (NNT) in both measurement conditions. Study outcomes greatly differed depending on which measurement method was used. When EMA was used to measure clinical symptoms, older adults who participated in the MBSR intervention had significantly higher mindfulness and significantly lower depression and anxiety than participants in the health education intervention at post-treatment. However, these significant changes in symptoms were not found when outcomes were measured with paper-and-pencil measures. The NNT for mindfulness and depression measures administered through EMA were approximately 25-50% lower than NNTs derived from paper-and-pencil administration. Sensitivity to change in anxiety was similar across administration modes. In conclusion, EMA measures of depression and mindfulness substantially outperformed paper-and-pencil measures with the same items. The additional resources associated with EMA in clinical trials would seem to be offset by its greater sensitivity to detect change in key outcome variables. PMID:26851494

  12. Prospective longitudinal study of subcortical brain volumes in individuals at high familial risk of mood disorders with or without subsequent onset of depression

    Papmeyer, Martina; Sussmann, Jessika E.; Stewart, Tiffany; Giles, Stephen; Centola, John G.; Zannias, Vasileios; Lawrie, Stephen M.; Whalley, Heather C.; McIntosh, Andrew M.

    2016-01-01

    Subcortical volumetric brain abnormalities have been observed in mood disorders. However, it is unknown whether these reflect adverse effects predisposing to mood disorders or emerge at illness onset. Magnetic resonance imaging was conducted at baseline and after two years in 111 initially unaffected young adults at increased risk of mood disorders because of a close family history of bipolar disorder and 93 healthy controls (HC). During the follow-up, 20 high-risk subjects developed major depressive disorder (HR-MDD), with the others remaining well (HR-well). Volumes of the lateral ventricles, caudate, putamen, pallidum, thalamus, hippocampus and amygdala were extracted for each hemisphere. Using linear mixed-effects models, differences and longitudinal changes in subcortical volumes were investigated between groups (HC, HR-MDD, HR-well). There were no significant differences for any subcortical volume between groups controlling for multiple testing. Additionally, no significant differences emerged between groups over time. Our results indicate that volumetric subcortical brain abnormalities of these regions using the current method appear not to form familial trait markers for vulnerability to mood disorders in close relatives of bipolar disorder patients over the two-year time period studied. Moreover, they do not appear to reduce in response to illness onset at least for the time period studied. PMID:26778365

  13. Prospective longitudinal study of subcortical brain volumes in individuals at high familial risk of mood disorders with or without subsequent onset of depression.

    Papmeyer, Martina; Sussmann, Jessika E; Stewart, Tiffany; Giles, Stephen; Centola, John G; Zannias, Vasileios; Lawrie, Stephen M; Whalley, Heather C; McIntosh, Andrew M

    2016-02-28

    Subcortical volumetric brain abnormalities have been observed in mood disorders. However, it is unknown whether these reflect adverse effects predisposing to mood disorders or emerge at illness onset. Magnetic resonance imaging was conducted at baseline and after two years in 111 initially unaffected young adults at increased risk of mood disorders because of a close family history of bipolar disorder and 93 healthy controls (HC). During the follow-up, 20 high-risk subjects developed major depressive disorder (HR-MDD), with the others remaining well (HR-well). Volumes of the lateral ventricles, caudate, putamen, pallidum, thalamus, hippocampus and amygdala were extracted for each hemisphere. Using linear mixed-effects models, differences and longitudinal changes in subcortical volumes were investigated between groups (HC, HR-MDD, HR-well). There were no significant differences for any subcortical volume between groups controlling for multiple testing. Additionally, no significant differences emerged between groups over time. Our results indicate that volumetric subcortical brain abnormalities of these regions using the current method appear not to form familial trait markers for vulnerability to mood disorders in close relatives of bipolar disorder patients over the two-year time period studied. Moreover, they do not appear to reduce in response to illness onset at least for the time period studied. PMID:26778365

  14. Electronic self-monitoring of mood using IT platforms in adult patients with bipolar disorder: A systematic review of the validity and evidence

    Faurholt-Jepsen, Maria; Munkholm, Klaus; Frost, Mads; Bardram, Jakob Eyvind; Kessing, Lars Vedel

    2016-01-01

    electronic self-monitoring tools as a method of evaluating mood compared to clinical rating scales for depression and mania and 2) to investigate the effect of electronic self-monitoring tools on clinically relevant outcomes in bipolar disorder. Methods: A systematic review of the scientific literature......-monitoring tools in patients with bipolar disorder reporting on validity of electronically self-reported mood ratings compared to clinical rating scales for depression and mania and 2) randomized controlled trials (RCT) evaluating electronic mood self-monitoring tools in patients with bipolar disorder. Results: A...... majority of studies. Conclusions: Electronic self-monitoring of mood in depression appears to be a valid measure of mood in contrast to self-monitoring of mood in mania. There are yet few studies on the effect of electronic self-monitoring of mood in bipolar disorder. The evidence of electronic self...

  15. Preschoolers' Psychopathology and Temperament Predict Mothers' Later Mood Disorders.

    Allmann, Anna E S; Kopala-Sibley, Daniel C; Klein, Daniel N

    2016-04-01

    Considerable research exists documenting the relationship between maternal mood disorders, primarily major depressive disorder (MDD), and a variety of negative child outcomes. By contrast, research exploring the reverse pathway whereby child traits are associated with later maternal mood disorders is much more limited. We examined whether young children's temperament and psychopathology predicted maternal mood disorders approximately 6 years later. Child temperament and symptoms were assessed at age three using semi-structured diagnostic interviews and parent-report inventories. Maternal psychopathology was assessed with semi-structured interviews when children were 3 and 9 years old. Mothers also reported on their marital satisfaction when children were 3 and 6 years old. Child temperamental negative affectivity (NA), depressive symptoms, and externalizing behavior problems significantly predicted maternal mood disorders over and above prior maternal mood, anxiety, and substance disorders. The link between children's early externalizing symptoms and maternal mood disorders 6 years later was mediated by maternal marital satisfaction 3 years after the initial assessment. These findings suggest that early child temperament and psychopathology contribute to risk for later maternal mood disorders both directly and through their impact on the marital system. Research indicates that effective treatment of maternal depression is associated with positive outcomes for children; however, this study suggests that treating early child problems may mitigate the risk of later maternal psychopathology. PMID:26219263

  16. Web-Based Intervention for Postpartum Depression: Formative Research and Design of the MomMoodBooster Program

    Danaher, Brian G; Milgrom, Jeannette; Seeley, John R; STUART, SCOTT; Schembri, Charlene; Tyler, Milagra S.; Ericksen, Jennifer; Lester, Whitney; Gemmill, Alan W; LEWINSOHN, PETER

    2012-01-01

    Background Postpartum depression is a significant public health problem affecting approximately 13% of women. There is strong evidence supporting Cognitive Behavioral Therapy (CBT) for successful psychosocial treatment. This treatment model combines cognitive and behavioral strategies to address pessimism, attributions for failure, low self-esteem, low engagement in pleasant activities, social withdrawal, anxiety, and low social support. Encouraging results have been reported for using Web-ba...

  17. Feasibility of an interval, inspiration-triggered nocturnal odorant application by a novel device: a patient-blinded, randomised crossover, pilot trial on mood and sleep quality of depressed female inpatients.

    Vitinius, Frank; Hellmich, Martin; Matthies, Annalena; Bornkessel, Fabian; Burghart, Heiner; Albus, Christian; Huettenbrink, Karl-Bernd; Vent, Julia

    2014-09-01

    It has been suggested that certain odorants positively affect mood, but this has not yet been scientifically tested in humans. The aim of the current study was to demonstrate the feasibility of a new odorant applicator and to assess the effects of nocturnal intermittent rose odorant application on mood, and quality of sleep and dreams in depressed female inpatients. We hypothesised that mood as primary outcome will improve. Twenty-seven normosmic, 18- to 49-year-old female, depressed inpatients were investigated in a randomised, placebo-controlled, crossover study. Exclusion criteria were rhinitis, hyp- or anosmia. During sleep, an interval-controlled, inspiration-triggered applicator added rose concentrate to the inspirated air. There were three consecutive nights of each odorant and placebo application and a wash-out phase. Patients completed standardised questionnaires on mood, dreams, and sleep quality. Four patients dropped out (n = 1: non-compliance in filling in the questionnaires, n = 3: intolerance of nasal tube). Otherwise, this novel odorant applicator was well tolerated. Application of the odorant showed no significant mood differences between rose and placebo, however, some subdomains of sleep quality and mood showed a positive trend towards improvement by rose application. The feasibility of this new device and of nasal tubes could be shown. Odorant application is well tolerated. It may have a positive influence on quality of mood and sleep in depressed patients. A longer application phase is planned to obtain convincing evidence for our hypothesis. PMID:24390040

  18. Occurrence of symptoms and depressive mood among working-aged coronary heart disease patients

    Sillanmäki Lauri H; Koskenvuo Markku J; Suominen Sakari B; Sumanen Markku PT; Mattila Kari J

    2004-01-01

    Abstract Background The typical symptoms of coronary heart disease (CHD), chest pain and breathlessness, are well-known. They are considered quite dramatic, and can thus be fairly reliably mapped by a survey. However, people might have other clearly unpleasant symptoms impairing quality of life. The aim of this study is to evaluate the appearance of these complaints of working-aged people with self-reported CHD. Methods The study consists of a postal questionnaire of randomly selected Finns i...

  19. Event related field (ERF) correlates of visual attentional processing during experimentally induced sad and happy mood states: an emotional rapid serial visual presentation (RSVP) paradigm.

    Louisa Coulson

    2010-01-01

    Previous studies report emotion-related, mood-congruent information processing biases in patients with Major Depression. We examined whether rapidly presented emotional word stimuli influenced visual attentional processing; recruiting a sample of 24 psychiatrically healthy participants following induced neutral and sad (n=12) or happy (n=12) mood. Mood induction procedures (MIPs) by means of self-referential statements and music were used to manipulate mood. We developed an emotional version ...

  20. The Bipolar II Depression Questionnaire: A Self-Report Tool for Detecting Bipolar II Depression

    Leung, Chi Ming; Lapyim, Chi; Yan, Connie T. Y.; Chan, Cheuk Chi; XIANG, YU-TAO; Mak, Arthur D. P.; Fok, Marcella Lei-Yee; Ungvari, Gabor S.

    2016-01-01

    Bipolar II (BP-II) depression is often misdiagnosed as unipolar (UP) depression, resulting in suboptimal treatment. Tools for differentiating between these two types of depression are lacking. This study aimed to develop a simple, self-report screening instrument to help distinguish BP-II depression from UP depressive disorder. A prototype BP-II depression questionnaire (BPIIDQ-P) was constructed following a literature review, panel discussions and a field trial. Consecutively assessed patien...

  1. Epilepsy and Mood Disorders

    Sermin Kesebir

    2012-03-01

    Full Text Available Mood disorders are the most common psychiatric comorbid disorder that affects quality of life and prognosis in epilepsy. The relation between depression and epilepsy is bidirectional. Not only the risk of having a depression among epilepsy cases is more than the healthy control cases, but also the risk of having epilepsy among depressive cases is more than the healthy control cases. People diagnosed with epilepsy are five times more likely than their peers to commit suicide. Moreover it seems that some epilepsy types like temporal lobe epilepsy have a much higher risk (25 times for suicide. Risk of suicide in epilepsy, which is independent from depression, increases more with the presence of depression. The common pathway between epilepsy, depression and suicide is hypofrontality and irregularity of serotonin metabolism. Contrary to depression, data on relationship between bipolar disorder and epilepsy is limited. However, mood disorder, mixed episodes with irritable character and mania are more frequent than assumed. As a matter of fact, both disorders share some common features. Both are episodic and can become chronic. Kindling phenomenon, irregularities in neurotransmitters, irregularities in voltage gate ion channels and irregularities in secondary messenger systems are variables that are presented in the etiologies of both disorders. Anticonvulsant drugs with mood regulatory effects are the common points of treatment. Understanding their mechanisms of action will clarify the pathophysiological processes. In this article, the relationhip between epilepsy and mood disorders, comorbidity, secondary states and treatment options in both cases have been discussed.

  2. The effect of a negative mood priming challenge on dysfunctional attitudes, explanatory style, and explanatory flexibility.

    Fresco, David M; Heimberg, Richard G; Abramowitz, Adrienne; Bertram, Tara L

    2006-06-01

    Ninety-seven undergraduates, 48 of whom had a history of self-reported major depression, completed measures of mood and cognitive style (e.g. explanatory style, explanatory flexibility, dysfunctional attitudes) prior to and directly after a negative mood priming challenge that consisted of listening to sad music and thinking about an upsetting past event. Eighteen of the previously depressed participants endorsed baseline levels of depression, explanatory style for negative events, and dysfunctional attitudes higher than levels reported by never depressed participants or euthymic participants with a history of depression. All three groups (never depressed participants, dysphoric participants with a history of depression, euthymic participants with a history of depression) demonstrated increases in dysphoria and dysfunctional attitudes in response to the negative mood priming challenge. Dysphoric participants with a history of depression, but not the other two groups, evidenced modest increases in explanatory style following the negative mood priming challenge. Finally, euthymic participants with a history of depression, but not the other two groups, evidenced drops in explanatory flexibility. Findings from the present study suggest that the cognitive theories of depression may benefit from examining both cognitive content and cognitive flexibility when assessing risk for depression. PMID:16719978

  3. Depression

    Grace Sherry L; Gucciardi Enza; Stewart Donna E

    2004-01-01

    Abstract Health Issue Depression causes significant distress or impairment in physical, social, occupational and other key areas of functioning. Women are approximately twice as likely as men to experience depression. Psychosocial factors likely mediate the risks for depression incurred by biological influences. Key Findings Data from the 1999 National Population Health Survey show that depression is more common among Canadian women, with an annual self-reported incidence of 5.7% compared wit...

  4. Depression

    STEWART, DONNA E.; Gucciardi, Enza; Grace, Sherry L.

    2004-01-01

    Health Issue Depression causes significant distress or impairment in physical, social, occupational and other key areas of functioning. Women are approximately twice as likely as men to experience depression. Psychosocial factors likely mediate the risks for depression incurred by biological influences. Key Findings Data from the 1999 National Population Health Survey show that depression is more common among Canadian women, with an annual self-reported incidence of 5.7% compared with 2.9% in...

  5. Mood Disorders after TBI

    Jorge, Ricardo E.; Arciniegas, David B

    2014-01-01

    In this article, we will examine the epidemiology and risk factors for the development of the most common mood disorders observed in the aftermath of TBI: depressive disorders and bipolar spectrum disorders. We will describe the classification approach and diagnostic criteria proposed in the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-V). We will also examine the differential diagnosis of post-TBI mood disorders and describe the mainstay of the evaluation ...

  6. Understanding Depression (For Parents)

    ... for Your Child All About Food Allergies Understanding Depression KidsHealth > For Parents > Understanding Depression Print A A ... or a child you know, seems depressed. About Depression Depression isn't just bad moods and occasional ...

  7. A randomised, feasibility trial of a tele-health intervention for Acute Coronary Syndrome patients with depression ('MoodCare': Study protocol

    Hare David L

    2011-02-01

    Full Text Available Abstract Background Coronary heart disease (CHD and depression are leading causes of disease burden globally and the two often co-exist. Depression is common after Myocardial Infarction (MI and it has been estimated that 15-35% of patients experience depressive symptoms. Co-morbid depression can impair health related quality of life (HRQOL, decrease medication adherence and appropriate utilisation of health services, lead to increased morbidity and suicide risk, and is associated with poorer CHD risk factor profiles and reduced survival. We aim to determine the feasibility of conducting a randomised, multi-centre trial designed to compare a tele-health program (MoodCare for depression and CHD secondary prevention, with Usual Care (UC. Methods Over 1600 patients admitted after index admission for Acute Coronary Syndrome (ACS are being screened for depression at six metropolitan hospitals in the Australian states of Victoria and Queensland. Consenting participants are then contacted at two weeks post-discharge for baseline assessment. One hundred eligible participants are to be randomised to an intervention or a usual medical care control group (50 per group. The intervention consists of up to 10 × 30-40 minute structured telephone sessions, delivered by registered psychologists, commencing within two weeks of baseline screening. The intervention focuses on depression management, lifestyle factors (physical activity, healthy eating, smoking cessation, alcohol intake, medication adherence and managing co-morbidities. Data collection occurs at baseline (Time 1, 6 months (post-intervention (Time 2, 12 months (Time 3 and 24 months follow-up for longer term effects (Time 4. We are comparing depression (Cardiac Depression Scale [CDS] and HRQOL (Short Form-12 [SF-12] scores between treatment and UC groups, assessing the feasibility of the program through patient acceptability and exploring long term maintenance effects. A cost-effectiveness analysis of the costs and outcomes for patients in the intervention and control groups is being conducted from the perspective of health care costs to the government. Discussion This manuscript presents the protocol for a randomised, multi-centre trial to evaluate the feasibility of a tele-based depression management and CHD secondary prevention program for ACS patients. The results of this trial will provide valuable new information about potential psychological and wellbeing benefits, cost-effectiveness and acceptability of an innovative tele-based depression management and secondary prevention program for CHD patients experiencing depression. Trial Registration Number Australia and New Zealand Clinical Trials Register (ANZCTR: ACTRN12609000386235

  8. [Psychotropic drugs and mechanisms of mood regulation].

    Deniker, P; Ginestet, D; Lôo, H

    1975-01-01

    Pharmaco-psychiatry has contributed to the study of mood regulation mechanisms (thymo-regulation). Anti-manic neuroleptics may induce depressions: anti-depressants may cause mood inversion (with artificial "bipolarity"), and lithium has an action upon alternating disorders of the mood. Correlations with the extrapyramidal syndromes are to be noted: parkinsonism going along with depression, and the antiparkinsonian action with the stimulation of mood. The extent of the role played by neuro-hormones, beta-inhibitors, and releasing-factors is still under discussion. The theoretical notion of mood regualtion makes it possible to single out a special type of psycho-stimulation implying manifold applications. PMID:815083

  9. The relation between mood and sexuality in heterosexual men.

    Bancroft, John; Janssen, Erick; Strong, David; Carnes, Lori; Vukadinovic, Zoran; Long, J Scott

    2003-06-01

    This paper reports on a study of individual variability in the relationship between negative mood and sexuality in men. Part 1 involves a questionnaire survey of 919 white heterosexual men, asking what typically happens to sexual interest and response when (a) depressed and (b) anxious/stressed, using the Mood and Sexuality Questionnaire (MSQ). Trait measures of sexual inhibition and excitation, depression, anxiety, and sensation seeking were also used. Relationships between trait measures and MSQ scores were tested using multiple linear and ordinal logistic regression. Of those reporting the experience of depression, 9.4% indicated increased and 42% decreased sexual interest when depressed; for anxiety/stress, the percentages were 20.6 and 28.3%, respectively. Increase in sexual interest during negative mood states was negatively related to age and trait measures of sexual inhibition and positively related to depression proneness and sexual excitation. In Part 2, the relationship between mood and sexuality was explored qualitatively, using in-depth interviews with 43 participants from Part 1. This supported the findings in Part 1, while finding more complex relations with depression than anxiety. Sex when depressed can serve needs for intimacy and self-validation as well as sexual pleasure. Sex when anxious appears to be more simply related to the calming effect of sexual release, plus a possible "excitation transfer" effect of anxious arousal. Further research is needed to explore these relationships in clinical mood disorders. Paradoxical increases of sexual interest with negative mood may help explain high risk as well as "out of control" patterns of sexual behavior. PMID:12807294

  10. Preventing mood and anxiety disorders in youth: a multi-centre RCT in the high risk offspring of depressed and anxious patients

    Nauta Maaike H

    2012-04-01

    Full Text Available Abstract Background Anxiety and mood disorders are highly prevalent and pose a huge burden on patients. Their offspring is at increased risk of developing these disorders as well, indicating a clear need for prevention of psychopathology in this group. Given high comorbidity and non-specificity of intergenerational transmission of disorders, prevention programs should target both anxiety and depression. Further, while the indication for preventive interventions is often elevated symptoms, offspring with other high risk profiles may also benefit from resilience-based prevention programs. Method/design The current STERK-study (Screening and Training: Enhancing Resilience in Kids is a randomized controlled clinical trial combining selected and indicated prevention: it is targeted at both high risk individuals without symptoms and at those with subsyndromal symptoms. Individuals without symptoms meet two of three criteria of the High Risk Index (HRI; female gender, both parents affected, history of a parental suicide (attempt. This index was developed in an earlier study and corresponds with elevated risk in offspring of depressed patients. Children aged 8–17 years (n = 204 with subthreshold symptoms or meeting the criteria on the HRI are randomised to one of two treatment conditions, namely (a 10 weekly individual child CBT sessions and 2 parent sessions or (b minimal information. Assessments are held at pre-test, post-test and at 12 and 24 months follow-up. Primary outcome is the time to onset of a mood or anxiety disorder in the offspring. Secondary outcome measures include number of days with depression or anxiety, child and parent symptom levels, quality of life, and cost-effectiveness. Based on models of aetiology of mood and anxiety disorders as well as mechanisms of change during interventions, we selected potential mediators and moderators of treatment outcome, namely coping, parent–child interaction, self-associations, optimism/pessimism, temperament, and emotion processing. Discussion The current intervention trial aims to significantly reduce the risk of intergenerational transmission of mood and anxiety disorders with a short and well targeted intervention that is directed at strengthening the resilience in potentially vulnerable children. We plan to evaluate the effectiveness and cost-effectiveness of such an intervention and to identify mechanisms of change. Trial registration NTR2888

  11. Classification of mood disorders

    Jules Angst

    2015-08-01

    derdiagnosis of bipolar disorder in depressed patients. Other contributory factors include that patients often do not feel ill or seek treatment for the consequences of their high mood, and that hypomania can be hidden by substance use disorders (SUD. Hidden hypomanic syndromes are important because associated with treatment resistance, high comorbidity with anxiety/panic and SUD, psychotic and cognitive symptoms, dementia and higher mortality. Anxiety, too, is doubtless a mood disorder but there is still no concept which integrates anxiety with bipolar disorder and depression. Classification involves the definition of artificial subgroups and is necessary for treatment and communication but clinicians, when in doubt, (...

  12. Anomalous Functional Brain Activation Following Negative Mood Induction in Children with Pre-School Onset Major Depression

    Pagliaccio, David; Luby, Joan; Gaffrey, Mike; Belden, Andrew; Botteron, Kelly; Gotlib, Ian H.; Barch, Deanna M.

    2011-01-01

    While major depressive disorder has been shown to be a significant mental health issue for school-age children, recent research indicates that depression can be observed in children as early as the preschool period. Yet, little work has been done to explore the neurobiological factors associated with this early form of depression. Given research suggesting a relation between adult depression and anomalies in emotion-related neural circuitry, the goal of the current study was to elucidate chan...

  13. MOOD PROFILING DURING OLYMPIC QUALIFYING JUDO COMPETITION: A CASE STUDY TESTING TRANSACTIONAL RELATIONSHIPS

    Matthew J. Stevens

    2006-07-01

    Full Text Available This case study investigated relationships between personality, mood states changes, coping strategies, self-set goals, and self-efficacy in an elite judo player. A transactional perspective of psychological responses over time was used to guide data analysis. The ambient mood is proposed to contribute to the interpretation of, and reaction to, events during competition, which lead to subsequent emotional responses. A male international Judo player completed a number of self-report measures before and during a 4-contest tournament. Measures included the EPQ, MCOPE, Brunel Mood Scale, self-set goals, and self-efficacy for goal attainment. State measures were completed after every contest. Results indicated high scores of self-efficacy to achieve performance goals and outcome goals. Pre-competition mood results indicated high scores on the Vigor and Anger subscales with moderate scores for Tension, and zero scores for Depressed mood, a mood profile that remained relatively stable after winning his first two contests. After losing his third contest, he reported symptoms of Depressed mood and indicated using self-blame as coping strategy during the contest. Before the fourth contest, he coped by using planning and increasing effort. These coping strategies were associated with reductions in Depressed mood and increases in Vigor. After finding out his next contest was against a former World Championship bronze medalist, self-set goals became performance and process with no outcome goal. On losing this contest, scores on the Anger and Depression subscales increased sharply, Fatigue scores increased slightly and Tension and Vigor reduced. Self-blame was used as a coping strategy when experiencing unpleasant emotions. Findings suggest that self-blame was associated with negative psychological states comprising depressed mood. Increasing effort and planning were associated with positive psychological states. Collectively, findings emphasize the value of using a transactional design to explore mood changes over time, and future research should investigate the effectiveness of applied interventions

  14. Psychotherapy of Mood Disorders

    Picardi, Angelo; Gaetano, Paola

    2014-01-01

    In the last decades, psychotherapy has gained increasing acceptance as a major treatment option for mood disorders. Empirically supported treatments for major depression include cognitive behavioural therapy (CBT), interpersonal psychotherapy (IPT), behavioural therapy and, to a lesser extent, short-term psychodynamic psychotherapy. Meta-analytic evidence suggests that psychotherapy has a significant and clinically relevant, though not large, effect on chronic forms of depression. Psychothera...

  15. Pilot Randomized Clinical Trial of an SSRI vs Bupropion: Effects on Suicidal Behavior, Ideation, and Mood in Major Depression

    Grunebaum, Michael F.; Ellis, Steven P.; Duan, Naihua; Burke, Ainsley K.; Oquendo, Maria A.; John Mann, J

    2011-01-01

    Randomized controlled trials in depressed patients selected for elevated suicidal risk are rare. The resultant lack of data leaves uncertainty about treatment in this population. This study compared a serotonin reuptake inhibitor with a noradrenergic/dopaminergic antidepressant in major depression with elevated suicidal risk factors. We conducted a double-blind, randomized, clinical pilot trial of paroxetine (N=36) or bupropion (N=38) in DSM IV major depression with a suicide attempt history ...

  16. Temperament and Character in Euthymic Major Depressive Disorder Patients: The Effect of Previous Suicide Attempts and Psychotic Mood Episodes

    Ekinci, Okan; Albayrak, Yakup; Ekinci, Aslı Erkan

    2012-01-01

    Objective The purpose of this study was to examine personality traits of patients with major depressive disorder and explore the possible connections between personality and clinical and sociodemographic variables. Methods The sociodemographic and clinical properties of 80 patients with major depression, who were euthymic according to Hamilton Depression Scale scores, were recorded. Their personality was evaluated by using Temperament and Character Inventory and results were compared with 80 ...

  17. MOOD CHANGES FOLLOWING GOLF AMONG SENIOR RECREATIONAL PLAYERS

    Haydn Jarrett

    2005-03-01

    Full Text Available Golf has been recommended as a relatively risk-free form of exercise for an ageing population. The aim of this study was to investigate the effects of playing a round of golf on mood states in recreational players. Ageing male golfers (N = 34; Age: M = 68.7, SD = 5.4 years completed a mood measure immediately before and after an 18-hole round of golf. Distance walked per game was measured using a pedometer. Results indicate reported scores on Anger, Depression, and Fatigue increased and Vigor reduced following the game. However, it should be noted that although there was an increase in unpleasant mood states, this should be seen in the context of the overall mood profile, which was positive. Pedometer results indicated golfers walked a mean distance of 10.21 km (± 1.11. Results show participants of this age-group engaged in a meaningful exercise session and that mood scores deteriorated following play. Findings from the present study show that elderly golfers experienced mood profiles following golf similar to younger athletes following competition. For golf to be recommended as an activity for promoting physical activity among an aging population, the player's ability to regulate unpleasant mood states should be considered. Future research should investigate the effects of experiencing negative mood states following golf on motivation to participate.

  18. Pessimistic Mood in Decompensated Narcissistic Patient.

    Ping-Suen Yang

    2004-04-01

    Full Text Available We report the negative emotional state as pessimistic mood of a case with narcissisticpersonality disorder during the period of narcissistic decompensation. In addition, we identifiedthe clinical differences between pessimistic mood and depressive disorder. An 28-yearoldunmarried woman experienced herself; her life and the external object as futile and disappointingafter repeated failure to satisfy her grandiose fantasies about the search for ideallove. The patient then gave up her formerly gratifying activities, and fell into a prolongedstate of negative emotions and passivity dominated by pessimistic mood characterized by anoverwhelming sense of futility. The patient did not respond to medical treatment with antidepressantsfirstly. However after a 2-year course of intensive psychotherapy , the patientwas able to restore her zest to find a new boyfriend with a more rational and realistic attitude.Clinically, decompensated narcissistic patients do not exhibit the typical attitude ofworthlessness or guilty feelings, and are devoid of certain specific depressive emotions(e.g.,sadness, sorrow, etc.. In contrast, decompenssted narcissistic patients with pessimistic moodexhibit a dominant sense of futility and other negative emotions presented as outrage anddisappointment. The purpose of this case report was to emphasize the importance to recognizeclinical features of pessimistic mood for the differential diagnosis and management ofthe decompensated narcissistic patient.

  19. Regional cerebral blood flow in mood disorders. I. Comparison of major depressives and normal controls at rest

    We measured regional cerebral blood flow with the xenon 133 inhalation technique in 41 patients with major depressive disorder and 40 matched, normal controls during an eyes-closed, resting condition. The depressed group had a marked reduction in global cortical blood flow. To examine topographic abnormalities, traditional multivariate analyses were applied, as well as a new scaled subprofile model developed to identify abnormal functional neural networks in clinical samples. Both approaches indicated that the depressed sample had an abnormality in topographic distribution of blood flow, in addition to the global deficit. The scaled subprofile model identified the topographic abnormality as being due to flow reduction in the depressed patients in selective frontal, central, superior temporal, and anterior parietal regions. This pattern may reflect dysfunction in the parallel distributed cortical network involving frontal and temporoparietal polymodal association areas. The extent of this topographic abnormality, as revealed by the scaled subprofile model, was associated with both patient age and severity of depressive symptoms

  20. The impact of a multidimensional exercise program on self-reported anxiety and depression in cancer patients undergoing chemotherapy: A phase II study

    Klausen, Julie Midtgaard; RÞrth, Mikael Rahbek; Stelter, Reinhard; TveterÄs, Anders; Andersen, Christina; Quist, Morten; MÞller, Tom; Adamsen, Lis Ørgaard

    2005-01-01

    Little is known about the role of exercise in improving cancer patients' mood while undergoing chemotherapy. In this phase II study changes in self-reported anxiety and depression and fitness (VO2max) are reported in relation to a 6-week, 9 h weekly, multidimensional exercise program. A total of 91...... patients receiving chemotherapy, between 18 and 65 years old, completed a Hospital Anxiety and Depression Scale Questionnaire (HADS; response rate 91%, adherence rate 78%). Anxiety (p < 0.001) and depression (p = 0.042) was significantly reduced. The mean ± SD of the change was [minus sign]1.14 ± 2.91 for...

  1. Mood Congruence Effect in Autobiographical Recall: Is Mood a Mediator ?

    Dra?e Saša; Desrichard Olivier

    2013-01-01

    In the present study we test the hypothesis that the effect of mood congruence in autobiographical recall is underlain by mood. Thirty-eight female participants were subjected to positive, negative and neutral mood inductions, and then asked to recall three personal memories. Participants’ mood was assessed using self-report questionnaires and by electromyograph (EMG) measurements of corrugator supercilii and zygomaticus major muscle activity. We replicated the congruence effect between...

  2. Depression - overview

    Depression may be described as feeling sad, blue, unhappy, miserable, or down in the dumps. Most of ... one time or another for short periods. Clinical depression is a mood disorder in which feelings of ...

  3. STEVENS JOHNSON SYNDROME DURING TREATMENT WITH LITHIUM AND VALPROATE IN MOOD DISORDER: A REPORT OF TWO CASES

    Misra, B.N.; Mohapatra, P. K.; D. Roy

    2002-01-01

    Very rarely Stevens Johnson Syndrome develops following drug therapy particularly Lithium and Valproate. Worldwide, the reports regarding Lithium and Valproate induced Stevens Johnson Syndrome are very few. Here, we present two cases of Stevens Johnson Syndrome following treatment with Lithium and Valproate for Mood Disorder.

  4. Use of standardised patients in the evaluation of a residency mood disorders curriculum: a brief report

    Kobus, A M; Heintzman, J; Garvin, R D

    2013-01-01

    Background and objectives The purpose of this paper is to describe the use of resident performance on an observed structured clinical examination (OSCE) as a tool to refine a mood disorders curriculum, and to disseminate a mood disorders OSCE for use in other residency settings.

  5. Testosterone and Depression

    ĆžĂŒkrĂŒ Kartalcı

    2010-12-01

    Full Text Available Androgens have various effects on human body and mood. Testosterone, a hormone mainly secreted from testes and adrenals, is one of the most potent androgens. Multiple studies have found that testosterone plays a role in regulating sexual activity, libido, social behaviors, aggression, cognitive functions, sleep control and well-being in men and women. Testosterone deficiency in hypogonadic or elderly men leads to neuropsychiatric problems, such as fatigue, loss of libido, irritability, insomnia and depressive mood. Testosterone replacement therapy consistently reverses these sequel in men. On the other hand, hyperandrogenic states in women are related to aggression and antisocial behavior, which might lead to depressive mood. Low testosterone levels may also result in depression among oophorectomized women. Because of such effects, a relationship between testosterone and depression has long been an issue of speculation, but yet very few studies have addressed this relation. Along with clinical studies, experimental and epidemiological studies show that testosterone is related to depression in men and women. But studies of testosterone concentrations in depression have yielded inconsistent results reporting low as well as high testosterone levels associated with depression. In this article, the physiological and psychological effects of testosterone and evidence regarding its relationship to depressive disorders and possible gender differences have been reviewed.

  6. Parent Prediction of Child Mood and Emotional Resilience: The Role of Parental Responsiveness and Psychological Control

    Margaret N. Lumley; Kristy L. Boughton

    2011-01-01

    Research consistently shows low to moderate agreement between parent and child reports of child mood, suggesting that parents are not always the best predictors of child emotional functioning. This study examines parental responsiveness and psychological control for improving prediction of early adolescent mood and emotional resilience beyond parent report of child emotional functioning. Participants were 268 early adolescents administered measures of depression symptoms, emotional resilience...

  7. A proof of principle for using adaptive testing in routine Outcome Monitoring: the efficiency of the Mood and Anxiety Symptoms Questionnaire -Anhedonic Depression CAT

    Smits Niels

    2012-01-01

    Full Text Available Abstract Background In Routine Outcome Monitoring (ROM there is a high demand for short assessments. Computerized Adaptive Testing (CAT is a promising method for efficient assessment. In this article, the efficiency of a CAT version of the Mood and Anxiety Symptom Questionnaire, - Anhedonic Depression scale (MASQ-AD for use in ROM was scrutinized in a simulation study. Methods The responses of a large sample of patients (N = 3,597 obtained through ROM were used. The psychometric evaluation showed that the items met the requirements for CAT. In the simulations, CATs with several measurement precision requirements were run on the item responses as if they had been collected adaptively. Results CATs employing only a small number of items gave results which, both in terms of depression measurement and criterion validity, were only marginally different from the results of a full MASQ-AD assessment. Conclusions It was concluded that CAT improved the efficiency of the MASQ-AD questionnaire very much. The strengths and limitations of the application of CAT in ROM are discussed.

  8. Diurnal pattern of serum BDNF before partial sleep deprivation in stress-related mood disorders – an association with therapy response in major depression

    Maria Giese

    2012-09-01

    Full Text Available Background : Depression is one of the most prevalent forms of mood disorders. Compelling evidence suggests that mood disorders are characterized by reduced neuronal plasticity, which can be brought about by exposure to stress. Furthermore, there is good agreement in considering key proteins such as the brain-derived neurotrophic factor (BDNF, as a central player for the effects of stress on brain function and plasticity and psychopathological implications. Still, there is a high non-responder rate in antidepressant therapy, which explains the need to find reliable predictors for adequate treatment. Previous studies revealed that plasma and serum BDNF levels in depressed patients were significantly lower than in healthy controls. Since the protein can cross the blood brain-barrier serum content correspondingly correlates with cortical BDNF concentrations suggesting BDNF levels as a promising candidate biomarker for depression and antidepressant treatment response. Methods : To investigate the association between serum BDNF levels and treatment outcome, blood was drawn from 28 patients with a major depressive episode (DMS-IV, ICD-10 that participated in a double-blind placebo controlled treatment study. All patients were treated with a stable mirtazapine monotherapy. Partial sleep deprivation (PSD was performed after one week. Placebo controlled additional morning treatment with the stimulant modafinil to reduce microsleep throughout the day was started during PSD and maintained over two weeks. Serum concentrations of BDNF and cortisol were assessed by an enzyme-linked immunosorbent assay (ELISA from day 1 (“before PSD” at 8 am, 2 pm, 8 pm and day 2 (“after PSD” at 8 am, 2 pm and 8 pm. Samples were appropriately diluted and detection of soluble BDNF or cortisol was carried out in an antibody sandwich format in duplicates and means were calculated for the corresponding group. Moreover, sleep EEG and microsleep episodes were recorded with a portable EEG. Depression severity using the Hamilton Depression Rating Scale and mood, tiredness and relaxation were assessed with visual analog scales (VASs for psychological functioning at days 1, 2 and 3 (“after recovery night” as well as after one and two weeks of ongoing treatment. Results : Notably, depressive patients who showed an acute HDRS-6 improvement after PSD exhibited a prominent diurnal pattern of serum BDNF levels during the day before PSD whereas acute non-responders did not show such a pattern and BDNF levels were rather constantly expressed. Serum BDNF levels were significantly elevated in acute responders compared to non-responders in the morning at 8.00 am before PSD corrected for Bonferroni (p>0.01. Also responders after two weeks (FU2 exhibited a prominent diurnal serum BDNF pattern before and after PSD on day one and two, while it was more pronounced after PSD. There was no diurnal pattern for non-responders after two weeks before; however, after PSD on day two an even modest diurnal change was visible in this group but less pronounced compared to FU2-responders. We found no association between treatment condition placebo vs. modafinil and response for acute neither response after two weeks. When we linked daily peak BDNF levels from day two at 2 pm with overall HDRS-6 improvement, responders were associated with elevated BDNF levels compared to non-responders on day three after recovery night already. Even after one (FU1 and two (FU2 weeks increased BDNF levels of day two at 2 pm were more prominent in the responder group. This difference between responders and non-responders of peak serum BDNF levels from 2 pm after PSD was statistically significant after two weeks. In addition, HDRS-6 improvement after two weeks of on-going treatment was significantly correlated with elevated serum BDNF levels in all patients. Moreover, peak levels of serum BDNF after PSD on day 2 at 2 pm were correlated with increased relaxation and improved mood in all depressive patients. In addition, placebo treated patients during PSD exhibited a significant increase of serum cortisol levels during PSD when compared to morning peak levels at 8 am between day one and two. There was no serum cortisol increase in the modafinil treated group during PSD intervention. Conclusions : Altogether, it seems that a diurnal pattern of serum BDNF during the day is necessarily associated with acute and response after two weeks in terms of partial sleep deprivation independently from additional treatment (modafinil vs. placebo. BDNF levels peaking in the morning and declining during the day seem to be favourable for an antidepressant response. Therefore, BDNF expression profile in serum at baseline could be used as possible predictor for therapy outcome.

  9. Stress and Depressed Mood in Medical Students, Law Students, and Graduate Students at McGill University.

    Helmers, Karin F.; Danoff, Deborah; Steinert, Yvonne; Young, Simon N.; Leyton, Marco

    1997-01-01

    Administration of the Derogatis Stress Profile to 509 medical students, 380 law students, and 215 graduate students at McGill University (Ontario) revealed that medical students are not greatly stressed relative to other groups, so other explanations must be sought for elevated levels of depression in some. One clear stressor found is the


  10. Temper Outbursts in Paediatric Obsessive-Compulsive Disorder and Their Association with Depressed Mood and Treatment Outcome

    Krebs, Georgina; Bolhuis, Koen; Heyman, Isobel; Mataix-Cols, David; Turner, Cynthia; Stringaris, Argyris

    2013-01-01

    Background: Temper outbursts in youth with obsessive-compulsive disorder (OCD) are a common source of concern, but remain poorly understood. This study examined a set of hypotheses related to: (a) the prevalence of temper outbursts in paediatric OCD, (b) the associations of temper outbursts with OCD severity and depressive symptoms; and (c) the


  11. Mood disorder with mixed, psychotic features due to vitamin b12 deficiency in an adolescent: case report

    Tufan Ali; Bilici Rabia; Usta Genco; Erdoğan Ayten

    2012-01-01

    Abstract Vitamin B12 is one of the essential vitamins affecting various systems of the body. Reports of psychiatric disorders due to its deficiency mostly focus on middle aged and elderly patients. Here we report a case of vitamin B 12 deficiency in a 16-year old, male adolescent who presented with mixed mood disorder symptoms with psychotic features. Chief complaints were “irritability, regressive behavior, apathy, crying and truancy” which lasted for a year. Premorbid personality was unrema...

  12. Female-specific mood disorders.

    Steiner, M

    1992-09-01

    Hormones are partial determinants of certain sexually dimorphic behaviors and interact with psychosocial, environmental, and other physiologic factors. The part played by sex hormones in the direct control of overt human behavior is, compared with that found in lower animals, slight and less readily definable. In humans, these hormones, although necessary for maintenance of libido and sexual behavior, seem to control the intensity of such behavior rather than its direction. In most women of reproductive age, the different phases of the menstrual cycle are not associated with major physical or psychologic discomfort. Some women actually report positive changes during the premenstrual period. Only 5-10% of women in this age group have changes in mood, sleep, eating habits, level of energy, and physical symptoms that appear to be linked temporally to the late-luteal phase of the cycle. It is plausible to assume that women with LLPDD are vulnerable to the menstrual cycle as a Zeitgeber. In these women, a cascade of events triggered originally along the HPG axis brings about the shift from an existing vulnerability to the actual manifestations of LLPDD and other forms of female-specific mood disorders. The degree of vulnerability becomes apparent at puberty when girls are exposed to increasing estrogenic influences. Particularly vulnerable times are the periods that mark shifts in the reproductive stages (menarche, the premenstruum, puerperium, and menopause), periods associated with major hormonal turmoil and psychosocial stresses. A conditioning-sensitization model has been described to explain the longitudinal course of affective disorders, and it also has been proposed for PMS. According to this model, even low levels of psychosocial stress are capable of triggering episodes of dysphoria in vulnerable previously sensitized subjects. LLPDD is associated strongly with a lifetime diagnosis of major depression, and the concurrent comorbidity in these women is also high. Future epidemiologic studies on depression should consider the effects of female-specific Zeitgeber on mood disorders in the populations studied. PMID:1521388

  13. Positive Affect Stimulation and Sustainment (PASS) Module for Depressed Mood: A preliminary investigation of treatment-related effects

    McMakin, Dana L.; Siegle, Greg J; Shirk, Stephen R.

    2011-01-01

    Positive affective functioning (PAF) is critical to the development, course and treatment of depressive symptoms. Targeting key features of PAF during treatment may provide a new angle through which to improve affective functioning and reduce symptoms. The current study was a treatment development trial for the Positive Affect Stimulation and Sustainment (PASS) Module. PASS is conceptualized as a means of capitalizing on positive events (e.g. planned through behavioral activation) by enhancin...

  14. Acceptability of Online Self-Help to People With Depression: Users’ Views of MoodGYM Versus Informational Websites

    Schneider, Justine; Sarrami Foroushani, Pooria; Grime, Paul; Thornicroft, Graham

    2014-01-01

    Background Little is known about the factors that influence acceptability of and adherence to online psychological interventions. Evidence is needed to guide further development of promising programs. Objective Our goal was to investigate users’ views of two online approaches to self-help for depression: computerized cognitive behavior therapy (cCBT) and informational websites, in a workplace context. Computerized CBT offers an inexpensive and accessible alternative to face-to-face therapy, a...

  15. GANGGUAN MOOD PADA STROKE

    Gabriella Tantular

    2015-10-01

    Full Text Available Stroke adalah salah satu sindrom neurologi yang dapat menimbulkan kecacatan dalam kehidupanmanusia. Salah  satu gejala yang dapat  timbul  setelah  seseorang  terkena  stroke adalah gangguanmood. Gangguan mood berhubungan dengan disabilitas fisik, beratnya stroke dan gangguan kognitif.Gangguan mood yang ditemukan pada stroke adalah depresi, gangguan afektif bipolar dan mania.Gambaran  gejala  berhubungan dengan  lesi  anatomis  stroke. Terapi  yang diberikan dapat  berupafarmakologis, psikoterapi, dan rehabilitasi. [MEDICINA 2015;46:33-36].Stroke is one of neurology syndrome that cause disability in human life. One of the symptoms thatappear after stroke was mood disorder. Mood disorder were related to physical disability, severity ofstroke  and  cognitive  dysfunction. Mood  disorder  found  in  stroke was  depression,  affective  bipolardisorder, and mania. Symptoms were associated with anatomical lesion. Treatment for this disorderare pharmacologic treatment, psychotherapy, and rehabilitation. [MEDICINA 2015;46:33-36].

  16. Light treatment of mood disorders

    Parry, Barbara L.; Maurer, Eva L.

    2003-01-01

    In 1981, seven patients with nonseasonal depression were treated with bright white light in 1982, bright artificial light was used to treat a manic-depressive patient with a seasonal mood cycle. In the last 20 years, a plethora of studies have further defined the depressive populations, who are responsive to light treatment; the optimal timing, intensity, spectral frequency, and duration of treatment; its comparison with other pharmacological interventions; predictors of response; side-effect...

  17. The Bipolar II Depression Questionnaire: A Self-Report Tool for Detecting Bipolar II Depression

    Leung, Chi Ming; Yim, Chi Lap; Yan, Connie T. Y.; Chan, Cheuk Chi; Xiang, Yu-Tao; Mak, Arthur D. P.; Fok, Marcella Lei-Yee; Ungvari, Gabor S.

    2016-01-01

    Bipolar II (BP-II) depression is often misdiagnosed as unipolar (UP) depression, resulting in suboptimal treatment. Tools for differentiating between these two types of depression are lacking. This study aimed to develop a simple, self-report screening instrument to help distinguish BP-II depression from UP depressive disorder. A prototype BP-II depression questionnaire (BPIIDQ-P) was constructed following a literature review, panel discussions and a field trial. Consecutively assessed patients with a diagnosis of depressive disorder or BP with depressive episodes completed the BPIIDQ-P at a psychiatric outpatient clinic in Hong Kong between October and December 2013. Data were analyzed using discriminant analysis and logistic regression. Of the 298 subjects recruited, 65 (21.8%) were males and 233 (78.2%) females. There were 112 (37.6%) subjects with BP depression [BP-I = 42 (14.1%), BP-II = 70 (23.5%)] and 182 (62.4%) with UP depression. Based on family history, age at onset, postpartum depression, episodic course, attacks of anxiety, hypersomnia, social phobia and agoraphobia, the 8-item BPIIDQ-8 was constructed. The BPIIDQ-8 differentiated subjects with BP-II from those with UP depression with a sensitivity/specificity of 0.75/0.63 for the whole sample and 0.77/0.72 for a female subgroup with a history of childbirth. The BPIIDQ-8 can differentiate BP-II from UP depression at the secondary care level with satisfactory to good reliability and validity. It has good potential as a screening tool for BP-II depression in primary care settings. Recall bias, the relatively small sample size, and the high proportion of females in the BP-II sample limit the generalization of the results. PMID:26963908

  18. The Bipolar II Depression Questionnaire: A Self-Report Tool for Detecting Bipolar II Depression.

    Leung, Chi Ming; Yim, Chi Lap; Yan, Connie T Y; Chan, Cheuk Chi; Xiang, Yu-Tao; Mak, Arthur D P; Fok, Marcella Lei-Yee; Ungvari, Gabor S

    2016-01-01

    Bipolar II (BP-II) depression is often misdiagnosed as unipolar (UP) depression, resulting in suboptimal treatment. Tools for differentiating between these two types of depression are lacking. This study aimed to develop a simple, self-report screening instrument to help distinguish BP-II depression from UP depressive disorder. A prototype BP-II depression questionnaire (BPIIDQ-P) was constructed following a literature review, panel discussions and a field trial. Consecutively assessed patients with a diagnosis of depressive disorder or BP with depressive episodes completed the BPIIDQ-P at a psychiatric outpatient clinic in Hong Kong between October and December 2013. Data were analyzed using discriminant analysis and logistic regression. Of the 298 subjects recruited, 65 (21.8%) were males and 233 (78.2%) females. There were 112 (37.6%) subjects with BP depression [BP-I = 42 (14.1%), BP-II = 70 (23.5%)] and 182 (62.4%) with UP depression. Based on family history, age at onset, postpartum depression, episodic course, attacks of anxiety, hypersomnia, social phobia and agoraphobia, the 8-item BPIIDQ-8 was constructed. The BPIIDQ-8 differentiated subjects with BP-II from those with UP depression with a sensitivity/specificity of 0.75/0.63 for the whole sample and 0.77/0.72 for a female subgroup with a history of childbirth. The BPIIDQ-8 can differentiate BP-II from UP depression at the secondary care level with satisfactory to good reliability and validity. It has good potential as a screening tool for BP-II depression in primary care settings. Recall bias, the relatively small sample size, and the high proportion of females in the BP-II sample limit the generalization of the results. PMID:26963908

  19. Validation of the Chinese version of the "Mood Disorder Questionnaire" for screening bipolar disorder among patients with a current depressive episode

    Gan Zhaoyu

    2012-01-01

    Full Text Available Abstract Background The Mood Disorder Questionnaire (MDQ is a well-recognized screening tool for bipolar disorder, but its Chinese version needs further validation. This study aims to measure the accuracy of the Chinese version of the MDQ as a screening instrument for bipolar disorder (BPD in a group of patients with a current major depressive episode. Methods 142 consecutive patients with an initial DSM-IV-TR diagnosis of a major depressive episode were screened for BPD using the Chinese translation of the MDQ and followed up for one year. The final diagnosis, determined by a special committee consisting of three trained senior psychiatrists, was used as a 'gold standard' and ROC was plotted to evaluate the performance of the MDQ. The optimal cut-off was chosen by maximizing the Younden's index. Results Of the 142 patients, 122 (85.9% finished the one year follow-up. On the basis of a semi-structured clinical interview 48.4% (59/122 received a diagnosis of unipolar depression (UPD, 36.9% (45/122 BPDII and 14.8% (18/122 BPDI. At the end of the one year follow-up,9 moved from UPD to BPD, 2 from BPDII to UPD, 1 from BPDII to BPDI, the overall rate of initial misdiagnosis was 16.4%. MDQ showed a good accuracy for BPD: the optimal cut-off was 4, with a sensitivity of 0.72 and a specificity of 0.73. When BPDII and BPDI were calculated independently, the optimal cut-off for BPDII was 4, with a sensitivity of 0.70 and a specificity of 0.73; while the optimal cut-off for BPDI was 5, with a sensitivity of 0.67 and a specificity of 0.86. Conclusions Our results show that the Chinese version of MDQ is a valid tool for screening BPD in a group of patients with current depressive episode on the Chinese mainland.

  20. Sleep disorders and depression: brief review of the literature, case report, and nonpharmacologic interventions for depression

    Luca A

    2013-08-01

    Full Text Available Antonina Luca,1 Maria Luca,2 Carmela Calandra2 1Department GF Ingrassia, Section of Neuroscience, 2Department of Medical and Surgery Specialties, Psychiatry Unit, University Hospital Policlinico-Vittorio Emanuele, Catania, Sicily, Italy Abstract: Sleep disorders are so frequently associated with depression that, in the absence of sleep complaints, a diagnosis of depression should be made with caution. Insomnia, in particular, may occur in 60%–80% of depressed patients. Depressive symptoms are important risk factors for insomnia, and depression is considered an important comorbid condition in patients with chronic insomnia of any etiology. In addition, some drugs commonly prescribed for the treatment of depression may worsen insomnia and impair full recovery from the illness. The aim of this paper is to review briefly and discuss the following topics: common sleep disturbances during depression (in particular pavor nocturnus, nightmares, hypersomnia, and insomnia; circadian sleep disturbances; and treatment of depression by manipulation of the sleep-wake rhythm (chronotherapy, light therapy, cycles of sleep, and manipulation of the sleep-wake rhythm itself. Finally, we present a case report of a 65-year-old Caucasian woman suffering from insomnia associated with depression who was successfully treated with sleep deprivation. Keywords: sleep disorders, depression, insomnia, sleep-wake rhythm

  1. A Pilot Evaluation of Associations Between Displayed Depression References on Facebook and Self-reported Depression Using a Clinical Scale

    Moreno, Megan Andreas; Christakis, Dimitri A; Egan, Katie G; Jelenchick, Lauren A; Cox, Elizabeth; Young, Henry; Villiard, Hope; Becker, Tara

    2011-01-01

    The objective of this study was to determine associations between displayed depression symptoms on Facebook and self-reported depression symptoms using a clinical screen. Public Facebook profiles of undergraduates from two universities were examined for displayed depression references. Profiles were categorized as depression symptom displayers or non-displayers. Participants completed an online PHQ-9 depression scale. Analyses examined associations between PHQ-9 score and depression symptom d...

  2. Mood and affect disorders.

    Tang, Michael H; Pinsky, Elizabeth G

    2015-02-01

    Depressive disorders are common in children and adolescents, with estimates for depressive episodes as high as 18.2% for girls and 7.7% for boys by age 17 years, and are a major cause of morbidity and even mortality. The primary care pediatrician should be able to (1) diagnose depressive disorders and use standardized instruments; (2) ask about suicide, self-harm, homicide, substance use, mania, and psychosis; (3) triage the severity of illness; (4) be aware of the differential diagnosis, including normal development, other depressive disorders, bipolar disorders, and comorbid disorders, such as anxiety and substance use; (5) refer to evidenced-based psychotherapies; (6) prescribe first-line medications; and (7) provide ongoing coordination in a medical home. Pediatric bipolar disorders and the new disruptive mood dysregulation disorder (DMDD) diagnoses are controversial but not uncommon, with prevalence estimates ranging from 0.8% to 4.3% in children at various ages. Although the pediatrician is not likely to be prescribing medications for children with bipolar disorder and DMDD diagnoses, all clinicians should be familiar with common neuroleptics and other mood stabilizers, including important potential adverse effects. Basic management of depressive and bipolar disorders is an important skill for primary care pediatricians. PMID:25646309

  3. Job strain and the risk of depression: is reporting biased?

    Kolstad, Henrik; Hansen, Åse Marie; Kérgaard, Anette; Thomsen, Jane F; Kaerlev, Linda; Mikkelsen, Sigurd; Grynderup, Matias Brþdsgaard; Mors, Ole; Rugulies, Reiner; Kristensen, Ann Suhl; Andersen, Niels Johan; Bonde, Jens Peter

    2011-01-01

    It is unknown whether the relation between job strain and depression reflects causal characteristics of the working environment or reporting bias. The authors investigated reporting bias by analyzing individual versus work-unit measures of job strain and the risk of depressive symptoms (n = 287) ...

  4. Postpartum Depression Facts

    ... Where can I find more information? Share Postpartum Depression Facts Download PDF Download ePub Download Mobi Order ... for herself or her family. What is postpartum depression? Postpartum depression is a mood disorder that can ...

  5. Post-vasectomy depression: a case report and literature review

    Subahani Shaik; Ravi Philip Rajkumar

    2014-01-01

    Vasectomy is a commonly performed and relatively safe procedure, with low reported rates of psychological morbidity, though there is some variability across studies. Depression following a vasectomy is relatively infrequent. A married man aged 30 developed a chronic depressive episode, lasting four years and resistant to an adequate trial of fluoxetine, following a vasectomy. His depression was heralded by a post-operative panic attack, and was accompanied by medically unexplained symptoms an...

  6. Relationship between maternal depression as a risk factor for childhood trauma and mood disorders in young adults / Relaçăo entre depressăo materna como fator de risco para trauma na infância e transtornos de humor em jovens

    Luana Porto, Barbosa; Luciana, Quevedo; Giovanna Del Grande Da, Silva; Karen, Jansen; Pedro, Magalhăes; Ricardo Tavares, Pinheiro; Ricardo Azevedo da, Silva.

    2014-07-01

    Full Text Available Contexto Depressăo materna pode ser um fator de risco para trauma na infância (TI), com consequente desenvolvimento de transtornos de humor (TH) em seus filhos na vida adulta. Objetivo Verificar a relaçăo entre depressăo materna (como fator de risco para TI) e TH em jovens. Métodos A amostra [...] foi composta de 164 jovens adultos e suas măes. A depressăo materna foi identificada por meio do Mini International Neuropsychiatric Interview (M.I.N.I.). Transtornos de humor nos jovens foram confirmados pela entrevista estruturada para o DSM-IV (SCID), enquanto o TI foi avaliado pelo Questionário de Trauma na Infância (CTQ). Resultados No grupo de jovens com TH, indivíduos que tiveram măes deprimidas apresentaram escores médios de TI mais altos em comparaçăo aos que năo tinham măes com depressăo (p Abstract in english Background Maternal depression may be a risk factor for childhood trauma (CT), with resultant offspring development of mood disorders (MD) in adult life. Objective To verify the relationship between maternal depression (as a risk factor for childhood trauma) and mood disorders in young adults. [...] Methods The sample was composed of 164 young adults and their mothers. Maternal depression was identified through the Mini International Neuropsychiatric Interview (M.I.N.I.). Mood Disorders in the young adults were confirmed with the Structured Interview for the DSM-IV (SCID), whereas the CT was evaluated using the Childhood Trauma Questionnaire (CTQ). Results In the group of young adults with MD, individuals who had depressed mothers presented higher mean scores of CT in comparison to the ones who did not have mothers with Depression (p

  7. Mood disorder as a manifestation of primary hypoparathyroidism: a case report

    Rosa, Regis G.; Barros, Alcina JS; de Lima, Antonio RB; Lorenzi, William; Da Rosa, Rafael R; Zambonato, Karine D; Alves, Gustavo V

    2014-01-01

    Introduction Primary hypoparathyroidism is a rare condition caused by parathyroid hormone deficiency and characterized by hypocalcemia. The clinical manifestations of primary hypoparathyroidism include tetany, seizures, paresthesias, dementia, and parkinsonism. Psychiatric manifestations such as mood disorders are unusual and may constitute a major diagnostic challenge, especially if the typical manifestations caused by hypocalcemia are absent. Case presentation The patient was a 22-year-old ...

  8. In the winning mood

    Marieke de Vries

    2008-01-01

    Full Text Available The present research aimed to test the role of mood in the Iowa Gambling Task (IGT; Bechara et al., 1994. In the IGT, participants can win or lose money by picking cards from four different decks. They have to learn by experience that two decks are overall advantageous and two decks are overall disadvantageous. Previous studies have shown that at an early stage in this card-game, players begin to display a tendency towards the advantageous decks. Subsequent research suggested that at this stage, people base their decisions on conscious gut feelings (Wagar and Dixon, 2006. Based on empirical evidence for the relation between mood and cognitive processing-styles, we expected and consistently found that, compared to a negative mood state, reported and induced positive mood states increased this early tendency towards advantageous decks. Our results provide support for the idea that a positive mood causes stronger reliance on affective signals in decision-making than a negative mood.

  9. Why do bad things happen to me? Attributional style, depressed mood, and persecutory delusions in patients with schizophrenia.

    Mehl, Stephanie; Landsberg, Martin W; Schmidt, Anna-Christine; Cabanis, Maurice; Bechdolf, Andreas; Herrlich, Jutta; Loos-Jankowiak, Stephanie; Kircher, Tilo; Kiszkenow, Stephanie; Klingberg, Stefan; Kommescher, Mareike; Moritz, Steffen; MĂŒller, Bernhard W; Sartory, Gudrun; Wiedemann, Georg; Wittorf, Andreas; Wölwer, Wolfgang; Wagner, Michael

    2014-11-01

    Theoretical models postulate an important role of attributional style (AS) in the formation and maintenance of persecutory delusions and other positive symptoms of schizophrenia. However, current research has gathered conflicting findings. In a cross-sectional design, patients with persistent positive symptoms of schizophrenia (n = 258) and healthy controls (n = 51) completed a revised version of the Internal, Personal and Situational Attributions Questionnaire (IPSAQ-R) and assessments of psychopathology. In comparison to controls, neither patients with schizophrenia in general nor patients with persecutory delusions (n = 142) in particular presented an externalizing and personalizing AS. Rather, both groups showed a "self-blaming" AS and attributed negative events more toward themselves. Persecutory delusions were independently predicted by a personalizing bias for negative events (beta = 0.197, P = .001) and by depression (beta = 0.152, P = .013), but only 5% of the variance in persecutory delusions could be explained. Cluster analysis of IPSAQ-R scores identified a "personalizing" (n = 70) and a "self-blaming" subgroup (n = 188), with the former showing slightly more pronounced persecutory delusions (P = .021). Results indicate that patients with schizophrenia and patients with persecutory delusions both mostly blamed themselves for negative events. Nevertheless, still a subgroup of patients could be identified who presented a more pronounced personalizing bias and more severe persecutory delusions. Thus, AS in patients with schizophrenia might be less stable but more determined by individual and situational characteristics that need further elucidation. PMID:24743864

  10. Stimulation dependent induction of fear and depression in deep brain stimulation: a case report

    Sabolek Michael

    2009-09-01

    Full Text Available Abstract Introduction Psychiatric side effects of deep brain stimulation are not uncommon. It is often limited to transient mood alterations. We report for the first time a case of acute stimulation-dependent fear during intraoperative test stimulation. Case presentation During test stimulation for electrode placement to the left subthalamic nucleus, a 58-year-old caucasian man with Parkinson's disease developed a severe reproducible feeling of fear together with elevated heart rate and sweating. Postoperatively, the patient developed a therapy refractory major depression in spite of excellent motor-control. Reprogramming the stimulator using a more rostral contact resulted in an abrupt and complete disappearance of the depressive syndrome. Conclusion Postoperative re-evaluation of the stimulation site of the patient inducing acute fear by analyzing his intraoperative microrecordings and Talairach coordinates revealed stimulation within his right substantia nigra. The contrast analysis of the postoperative stimulation site suggests induction of depression in the patient by stimulation of the caudal part of his subthalamic nucleus. Acute psychiatric side effects of deep brain stimulation are relatively rare but must not be overlooked while concentrating on the improvement of motor deficit.

  11. Patient Mood and Instrumental Activities of Daily Living in Alzheimer Disease: Relationship Between Patient and Caregiver Reports.

    Votruba, Kristen L; Persad, Carol; Giordani, Bruno

    2015-09-01

    This retrospective study investigated the relationship between self-reports and caregiver perceptions of patients' depressive symptoms and the respective ability of these reports to predict instrumental activities of daily living (IADLs) beyond what is accounted for by cognitive abilities in 71 patients with mild Alzheimer disease. Patients completed the Geriatric Depression Scale-Short Form, and caregivers completed the Behavior Rating Scale for Dementia assessing their perception of patients' depressive symptoms. Caregivers also completed IADL items from the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory. Cognitive measures included the Mini-Mental State Examination, Logical Memory from the Wechsler Memory Scale III, and Trail Making Test, Part B. The relationship between self-reported depressive symptoms and caregiver report of patients' depressive symptoms showed a trend toward significance (r = .22, P = .06). Measures of depressive symptoms significantly predicted 12.5% of the variance in IADLs performance, beyond that accounted for by patient demographics and cognitive functioning. Interestingly, patients' reports, rather than caregivers', were particularly useful in this prediction. PMID:26071443

  12. Modified electroconvulsive therapy for recurrent major depressive disorder in a meningioma patient: a case report of clinical experience.

    Nakatake, Masayuki; Teraishi, Toshiya; Ide, Makoto; Wakizono, Tomoki; Ogawa, Tetsuo; Kuwahara, Tatsuro; Yoshino, Aihide; Nomura, Soichiro

    2010-09-01

    Electroconvulsive therapy (ECT) is primarily indicated for mood disorders and schizophrenia. Clinicians may encounter cases in which ECT is administered to patients with various kinds of complications. However, to our knowledge, no detailed medical guideline is available about the indications for ECT in psychiatric illness complicated with a concomitant brain tumor, which is one of the most likely physical complications that can directly affect ECT. We report a case in which 3 courses of modified ECT (m-ECT) were successfully administered without any neurological deterioration to a patient, who was frequently hospitalized for recurrent depressive disorder with stupor. We did not undertake any additional measures for reducing adverse events derived from the meningioma during m-ECT. In this report, we discuss the relation between brain tumor and depression. PMID:21222352

  13. Sensitivity and specificity of the Major Depression Inventory in outpatients

    Noteboom Annemieke; Dekker Jack; Cuijpers Pim; Smits Niels; Peen Jaap

    2007-01-01

    Abstract Background The Major Depression Inventory (MDI) is a new, brief, self-report measure for depression based on the DSM-system, which allows clinicians to assess the presence of a depressive disorder according to the DSM-IV, but also to assess the severity of the depressive symptoms. Methods We examined the sensitivity, specificity, and psychometric qualities of the MDI in a consecutive sample of 258 psychiatric outpatients. Of these patients, 120 had a mood disorder (70 major depressio...

  14. Benefits from aerobic exercise in patients with major depression: a pilot study

    Dimeo, F; Bauer, M.; Varahram, I; Proest, G; Halter, U

    2001-01-01

    Background—Several reports indicate that physical activity can reduce the severity of symptoms in depressed patients. Some data suggest that even a single exercise bout may result in a substantial mood improvement.

  15. Rumination, anxiety, depressive symptoms and subsequent depression in adolescents at risk for psychopathology: a longitudinal cohort study

    Wilkinson, Paul O.; Croudace, Tim J.; Goodyer, Ian M.

    2013-01-01

    Background A ruminative style of responding to low mood is associated with subsequent high depressive symptoms and depressive disorder in children, adolescents and adults. Scores on self-report rumination scales correlate strongly with scores on anxiety and depression symptom scales. This may confound any associations between rumination and subsequent depression. Methods Our sample comprised 658 healthy adolescents at elevated risk for psychopathology. This study applied ordinal item (non-lin...

  16. MOOD AND PERFORMANCE IN YOUNG MALAYSIAN KARATEKA

    Rebecca S. K. Wong

    2006-07-01

    Full Text Available In an attempt to test the conceptual model by Lane and Terry, the purposes of this study were 1 to assess mood states in non-depressed and depressed young karate athletes; 2 to assess mood states in relation to performance in young karate athletes. The participants were recruited from the 2004 Malaysian Games (72 males, 19.20 ± 1.16 years; 37 females, 18.78 ± 0.88 years. The athletes were divided into winners (medalists and losers. The Brunel Mood Scale (BRUMS was administered prior to the start of competition. MANOVA was employed to treat the data, while Pearson correlations were calculated for mood states in each depressed mood group and by gender. In terms of non-depressed and depressed mood, tension in the females was higher in the depressed group (5.61 ± 3.02 vs. 3.11 ± 1.90, p = 0.026, eta2 = 0.133, as was fatigue (3.64 ± 2.61 vs. 0.89 ± 1.69, p = 0.006, eta2 = 0.199. Tension in the males was higher in the depressed group (4.41 ± 2.52 vs. 1.50 ± 1.55, p < 0.001, eta2 = 0.215, as was anger (1.43 ± 1.88 vs. 0.25 ± 1.00, p = 0.019, eta2 = 0.076. The highest associations among mood subscales were between anger and depression (r = 0.57, and between depression and fatigue ( r = 0.55 in depressed males. The female winning karateka scored higher on anger (3.08 ± 2.96 vs. 1.29 ± 2.24, p = 0.046, eta2 = 0.109. The highest correlations between mood dimensions in depressed females were between depression and anger (r = 0.85 and between depression and confusion (r = 0.85. Contrary to previous research on the influence of depression on anger, only the female winners scored higher on anger. Several negative mood dimensions were higher in both male and female depressed groups, lending some support to the conceptual model advanced by Lane and Terry

  17. USE OF TRANYLCYPROMINE IN SEVERE RESISTANT DEPRESSION : A CASE REPORT

    Maulik, Pallab K.; Das, Sudipto; Saxena, Shekhar

    1999-01-01

    This case report describes the improvement obtained by using tranylcypromine in a patient of severe treatment resistant depression. The adverse effects faced and steps taken to overcome them have also been discussed.

  18. Restriction of meat, fish, and poultry in omnivores improves mood: A pilot randomized controlled trial

    Beezhold Bonnie L

    2012-02-01

    Full Text Available Abstract Background Omnivorous diets are high in arachidonic acid (AA compared to vegetarian diets. Research shows that high intakes of AA promote changes in brain that can disturb mood. Omnivores who eat fish regularly increase their intakes of eicosapentaenoic acid (EPA and docosahexaenoic acid (DHA, fats that oppose the negative effects of AA in vivo. In a recent cross-sectional study, omnivores reported significantly worse mood than vegetarians despite higher intakes of EPA and DHA. This study investigated the impact of restricting meat, fish, and poultry on mood. Findings Thirty-nine omnivores were randomly assigned to a control group consuming meat, fish, and poultry daily (OMN; a group consuming fish 3-4 times weekly but avoiding meat and poultry (FISH, or a vegetarian group avoiding meat, fish, and poultry (VEG. At baseline and after two weeks, participants completed a food frequency questionnaire, the Profile of Mood States questionnaire and the Depression Anxiety and Stress Scales. After the diet intervention, VEG participants reduced their EPA, DHA, and AA intakes, while FISH participants increased their EPA and DHA intakes. Mood scores were unchanged for OMN or FISH participants, but several mood scores for VEG participants improved significantly after two weeks. Conclusions Restricting meat, fish, and poultry improved some domains of short-term mood state in modern omnivores. To our knowledge, this is the first trial to examine the impact of restricting meat, fish, and poultry on mood state in omnivores.

  19. Depression history, depression vulnerability and the experience of everyday negative events

    O’Grady, Megan A.; Tennen, Howard; Armeli, Stephen

    2010-01-01

    This study examined whether deficits in dealing with daily problems emerge before a depressive episode (i.e., pre-existing vulnerability) or after a depressive episode (i.e., psychosocial scar). Participants completed a 30-day daily diary in which they reported their most negative event of the day, their appraisals of that event, and their mood. Three years later, they completed a structured depression interview. The sample consisted of 350 college students, 24 of whom had a past history of d...

  20. Reproductive Hormones and Mood Disorders

    Sermin Kesebir

    2010-12-01

    Full Text Available During the menstrual cycle, pregnancy and breast-feeding periods, as well as in menopausal and post-menopausal periods, the physiological and psychological processes that change according to the hormonal fluctuations influence every women similarly and each one differently. These physiological processes are controlled by neuroendocrine sequences, of which the hypothalamo-pituitary-adrenal axis and the hypothalamo-pituitary-gonadal axis are the most important ones. The hypothalamo-pituitary-gonadal axis affects mood, anxiety, cognition and pain. The interaction of these hormones with mood and behavior is bidirectional. The differences in phenomenology and epidemiology of mood disorders with regards to gender can be explained with the effects of hormones. All of the periods mentioned above are related with mood disorders at terms of risk factors, disease symptoms, progress of disease and response to treatment. Epidemiologic data supports the relationship between the mood disorders and reproductive processes. The prevalence of major depression increases in women with the menarche and ceases in post- menopausal period. Similarly, the initial symptoms of bipolar disorder begins around the menarche period in 50% of the cases. Despite proper treatment, some female patients with major depression experience recurrence during the premenstrual period of their menstrual cycles. The conformity and change in a woman’s brain during pregnancy is controlled dominantly by the neuroendocrine systems, while it is controlled by the external stimuli actively related to the baby during nursing period. The changes that occur are closely related to postpartum mood disorders. Again, all the changes and suspension of medication during this procedure are risk factors for early depressive and dysphoric situations. Variables of a wide range, from follicle stimulating hormone, melatonin, and sleep to body mass index interact with mood disorders in menopausal and post-menopausal periods. Interest on the effects of gonadal steroids on the central nervous system has grown parallel with our increasing knowledge. In the last decade, the place of hormonal treatments in the treatment of mood disorders have been discussed continously. During this period, along with the anti-depressant efficacy of estrogen, anti-manic efficacy of tamoxifen was also demonstrated in several studies. In this paper, the complex relationship between the physiological changes and the mood disorders during a menstrual cycle, pregnancy, nursing, menopausal and post-menopausal periods are briefly reviewed and discussed over the reproductive hormones in the context of etiology, phenomenology and treatment.

  1. Nonlinear time-series approaches in characterizing mood stability and mood instability in bipolar disorder.

    Bonsall, MB; Wallace-Hadrill, SM; Geddes, JR; Goodwin, GM; Holmes, EA

    2012-01-01

    Bipolar disorder is a psychiatric condition characterized by episodes of elevated mood interspersed with episodes of depression. While treatment developments and understanding the disruptive nature of this illness have focused on these episodes, it is also evident that some patients may have chronic week-to-week mood instability. This is also a major morbidity. The longitudinal pattern of this mood instability is poorly understood as it has, until recently, been difficult to quantify. We prop...

  2. A PER3 Polymorphism Interacts with Sleep Duration to Influence Transient Mood States in Women

    Gobin, Christina M.; Fins, Ana I.; Craddock, Travis J.A.; Tartar, Aurélien; Tartar, Jaime L.

    2016-01-01

    Background: Expression of the clock family of genes in the suprachiasmatic nuclei (SCN) regulates the molecular control of circadian timing. Increasing evidence also implicates clock gene activity in the development of mood disorders. In particular, variation in the PER3 clock gene has been shown to influence diurnal preference and sleep homeostasis. However, there is not currently a clear association between PER3 polymorphisms and mood. This is possibly because the PER3 gene has been shown to influence homeostatic sleep drive, rather than circadian timing, and the PER3 gene may be behaviorally relevant only under chronic sleep loss conditions. Methods: To test the association between PER3 allele status and impaired mood, a total of 205 healthy women were genotyped for PER3 allele status and responded to previously-validated psychological questionnaires surveying self-reported sleep habits (MEQ, PSQI) and mood. Our mood measures included two measures of short-term, transient mood (state anxiety and mood disturbance) and two measures of longer term, ongoing mood (trait anxiety and depressive symptomology). Results: The PER3 genotype distribution was 88 (42.9%) for PER3(4/4), 98 (47.8%) for PER3(4/5), and 19 (9.3%) for PER3(5/5). Our sleep duration x genotype interaction analyses showed that, relative to longer allele carriers, PER3(4/4) genotypes were at greater risk for transient psychological effects (mood and state anxiety) when they reported reduced sleep durations. Conclusion: Sleep duration plays a critical role in understanding the extent to which PER3 allele status relates to mood states.

  3. Outpatient triple chronotherapy for bipolar depression: case report.

    Gottlieb, John F; Terman, Michael

    2012-09-01

    There is an urgent need for rapid, effective, and safe treatments for bipolar depression. Triple chronotherapy is a combination of sleep deprivation, sleep phase advance, and bright light therapy that has been shown to induce accelerated and sustained remissions in bipolar depression. This case report describes the first outpatient program designed to administer triple chronotherapy and reviews the organizational and clinical requirements for providing such care. PMID:22995965

  4. Depression, anxiety and major adverse cardiovascular and cerebrovascular events in patients following coronary artery bypass graft surgery

    Tully, Phillip J; Winefield, Helen R; Baker, Robert A; Denollet, Johan; Pedersen, Susanne S; Wittert, Gary A; Turnbull, Deborah A

    2015-01-01

    anxiety disorders were arranged into the distress cluster (major depression, dysthymia, generalized anxiety disorder, post-traumatic stress disorder) and fear cluster (panic disorder, agoraphobia, social phobia). Patients also completed the self-report Mood and Anxiety Symptom Questionnaire, measuring...

  5. Diagnosis, phenomenology and treatment of poststroke depression

    Starkstein Sergio E

    2002-01-01

    Full Text Available Diagnosing depression in stroke patients is a challenge in neuropsychiatry since depression symptoms may overlap neurological deficit signs. The best approach is to assess the presence of depressive symptoms using semi-structured or structured psychiatric interviews, such as the Present State Exam, the Structured Clinical Interview for DSM-IV or the Schedules for Clinical Assessment in Neuropsychiatry. The diagnosis of a depressive syndrome should be made according to standardized diagnostic criteria for mood disorders due to neurological disease such as in the DSM-IV or ICD-10. Depression rating scales such as the Hamilton Depression Scale and the Center for Epidemiologic Scales for Depression may be used to rate the depression severity and monitor the progression of antidepressant treatment. Most studies have reported the effectiveness of pharmacological treatment in patients with post-stroke depression, and there is preliminary evidence that the degree of impairment in activities of daily living (ADL may improve as well.

  6. The Effects of Musical Mood Induction on Creativity.

    Adaman, Jill E.; Blaney, Paul H.

    1995-01-01

    A music mood-induction procedure was used to induce either elated, depressed, or neutral mood in 71 college undergraduates. Creativity measures revealed that the subjects in the elated and depressed groups showed significantly greater creativity than subjects in the neutral group. (Author/DB)

  7. Depression and Smoking

    ... Quit Stress & Mood Stress & Mood Smoking & Mood Stress Depression Anger Weight Management Weight Management Smoking and Weight Healthy Weight Loss Being Comfortable in Your Own Skin Your Weight Loss Expectations & Goals Healthier Lifestyle Healthier Lifestyle Physical Fitness Food & Nutrition Sleep, Stress & ...

  8. Depressive symptoms in schizophrenic patients

    Gozdzik-Zelazny A

    2011-12-01

    Full Text Available Abstract Distinction between true negative and depressive symptoms in schizophrenia is difficult. In the present study we seek to establish the psychological profile of depression-prone schizophrenic patients. We addressed the issue by comparing the expression of psychological indices, such as the feelings of being in control of events, anxiety, mood, and the style of coping with stress in depressive and non-depressive schizophrenics. We also analyzed the strength of the association of these indices with the presence of depressive symptoms. A total of 49 patients (18 women and 31 men, aged 23-59 were enrolled into the study, consisting of a self-reported psychometric survey. We found that the prevalence of clinically significant depression in schizophrenic patients was 61%. The factors which contributed to the intensification of depressive symptoms were the external locus of control, anxiety, gloomy mood, and the emotion-oriented coping with stress. We conclude that psychological testing may discern those schizophrenic patients who would be at risk of depression development and may help separate the blurred boundaries between depressive and negative symptoms of schizophrenia.

  9. Stepped care for depression and anxiety: from primary care to specialized mental health care: a randomised controlled trial testing the effectiveness of a stepped care program among primary care patients with mood or anxiety disorders

    Seekles Wike

    2009-06-01

    Full Text Available Abstract Background Mood and anxiety disorders are highly prevalent and have a large impact on the lives of the affected individuals. Therefore, optimal treatment of these disorders is highly important. In this study we will examine the effectiveness of a stepped care program for primary care patients with mood and anxiety disorders. A stepped care program is characterized by different treatment steps that are arranged in order of increasing intensity. Methods This study is a randomised controlled trial with two conditions: stepped care and care as usual, whereby the latter forms the control group. The stepped care program consists of four evidence based interventions: (1 Watchful waiting, (2 Guided self-help, (3 Problem Solving Treatment and (4 Medication and/or specialized mental health care. The study population consists of primary care attendees aged 18–65 years. Screeners are sent to all patients of the participating general practitioners. Individuals with a Diagnostic and Statistical Manual of mental disorders (DSM diagnosis of major depression, dysthymia, panic disorder (with or without agoraphobia, generalized anxiety disorder, or social phobia are included as well as individuals with minor depression and anxiety disorders. Primary focus is the reduction of depressive and anxiety symptoms. Both conditions are monitored at 8, 16 and 24 weeks. Discussion This study evaluates the effectiveness of a stepped care program for patients with depressive and anxiety disorder. If effective, a stepped care program can form a worthwhile alternative for care as usual. Strengths and limitations of this study are discussed. Trial Registration Current Controlled Trails: ISRCTN17831610.

  10. Intramuscular ketamine in acute depression: A report on two cases

    Harihar, Chilukuri; Dasari, Padmavathy; Srinivas, Jakka Sriramulu

    2013-01-01

    It takes about 2 weeks for the onset of antidepressant action of drugs while electroconvulsive therapy though faster, is a cumbersome procedure requiring an anaesthetist and at least a minor operation theatre. Recent studies have shown that Ketamine, when given to severely depressed patients in the dose of 0.5 mg/kg as a slow intravenous infusion over 40 minutes, brought about acute relief from depression and amelioration of suicidal risk within a few hours. The improvement, however, was transient and lasted for up to a week but could be sustained by further weekly or biweekly injections. As the dose of ketamine administered was found to be safe, it was now tried in the intramuscular route in two severely depressed patients with similar rapid improvement. The cases are reported here which pave way for an easier mode of treating acute depression. PMID:23825857

  11. Improving mood with psychoanalytic and cognitive therapies (IMPACT: a pragmatic effectiveness superiority trial to investigate whether specialised psychological treatment reduces the risk for relapse in adolescents with moderate to severe unipolar depression: study protocol for a randomised controlled trial

    Suckling John

    2011-07-01

    Full Text Available Abstract Background Up to 70% of adolescents with moderate to severe unipolar major depression respond to psychological treatment plus Fluoxetine (20-50 mg with symptom reduction and improved social function reported by 24 weeks after beginning treatment. Around 20% of non responders appear treatment resistant and 30% of responders relapse within 2 years. The specific efficacy of different psychological therapies and the moderators and mediators that influence risk for relapse are unclear. The cost-effectiveness and safety of psychological treatments remain poorly evaluated. Methods/Design Improving Mood with Psychoanalytic and Cognitive Therapies, the IMPACT Study, will determine whether Cognitive Behavioural Therapy or Short Term Psychoanalytic Therapy is superior in reducing relapse compared with Specialist Clinical Care. The study is a multicentre pragmatic effectiveness superiority randomised clinical trial: Cognitive Behavioural Therapy consists of 20 sessions over 30 weeks, Short Term Psychoanalytic Psychotherapy 30 sessions over 30 weeks and Specialist Clinical Care 12 sessions over 20 weeks. We will recruit 540 patients with 180 randomised to each arm. Patients will be reassessed at 6, 12, 36, 52 and 86 weeks. Methodological aspects of the study are systematic recruitment, explicit inclusion criteria, reliability checks of assessments with control for rater shift, research assessors independent of treatment team and blind to randomization, analysis by intention to treat, data management using remote data entry, measures of quality assurance, advanced statistical analysis, manualised treatment protocols, checks of adherence and competence of therapists and assessment of cost-effectiveness. We will also determine whether time to recovery and/or relapse are moderated by variations in brain structure and function and selected genetic and hormone biomarkers taken at entry. Discussion The objective of this clinical trial is to determine whether there are specific effects of specialist psychotherapy that reduce relapse in unipolar major depression in adolescents and thereby costs of treatment to society. We also anticipate being able to utilise psychotherapy experience, neuroimaging, genetic and hormone measures to reveal what techniques and their protocols may work best for which patients. Trial Registration Current Controlled Trials ISRCTN83033550

  12. Psychotherapy of mood disorders.

    Picardi, Angelo; Gaetano, Paola

    2014-01-01

    In the last decades, psychotherapy has gained increasing acceptance as a major treatment option for mood disorders. Empirically supported treatments for major depression include cognitive behavioural therapy (CBT), interpersonal psychotherapy (IPT), behavioural therapy and, to a lesser extent, short-term psychodynamic psychotherapy. Meta-analytic evidence suggests that psychotherapy has a significant and clinically relevant, though not large, effect on chronic forms of depression. Psychotherapy with chronic patients should take into account several important differences between patients with chronic and acute depression (identification with their depressive illness, more severe social skill deficits, persistent sense of hopelessness, need of more time to adapt to better circumstances). Regarding adolescent depression, the effectiveness of IPT and CBT is empirically supported. Adolescents require appropriate modifications of treatment (developmental approach to psychotherapy, involvement of parents in therapy). The combination of psychotherapy and medication has recently attracted substantial interest; the available evidence suggests that combined treatment has small but significant advantages over each treatment modality alone, and may have a protective effect against depression relapse or recurrence. Psychobiological models overcoming a rigid brain-mind dichotomy may help the clinician give patients a clear rationale for the combination of psychological and pharmacological treatment. In recent years, evidence has accumulated regarding the effectiveness of psychological therapies (CBT, family-focused therapy, interpersonal and social rhythm therapy, psychoeducation) as an adjunct to medication in bipolar disorder. These therapies share several common elements and there is considerable overlap in their actual targets. Psychological interventions were found to be useful not only in the treatment of bipolar depressive episodes, but in all phases of the disorder. PMID:25493093

  13. Depression and Suicide Risk

    Depression and Suicide Risk (2014) Definition: A mood disorder that causes a persistent feeling of sadness and loss of interest. It ... mental disorders, recurrent episodes and higher rates of suicide. New Classification in the DSMV: xi ‱ Major depressive ...

  14. Screening for Depression

    Depression and Bipolar Support Alliance Crisis Hotline Information Coping with a Crisis Suicide Prevention Information Psychiatric Hospitalization ... training, events Visit the podcast archive Mood Disorders Depression Bipolar Disorder Anxiety Screening Center Co-occurring Illnesses/ ...

  15. Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees

    Payne, Jennifer L.; Klein, Sarah R; Zamoiski, Rachel B.; Zandi, Peter P.; Bienvenu, Oscar J; MacKinnon, Dean F.; Mondimore, Francis M.; Schweizer, Barbara; SWARTZ, KAREN L.; Crowe, Raymond P.; Scheftner, William A.; Weissman, Myrna M.; Levinson, Douglas F.; Depaulo, J Raymond; Potash, James B

    2009-01-01

    We sought to determine whether premenstrual mood symptoms exhibit familial aggregation in bipolar disorder or major depression pedigrees. Two thousand eight hundred seventy-six women were interviewed with the Diagnostic Interview for Genetic Studies as part of either the NIMH Genetics Initiative Bipolar Disorder Collaborative study or the Genetics of Early Onset Major Depression (GenRED) study and asked whether they had experienced severe mood symptoms premenstrually. In families with two or ...

  16. Method of treating depression

    Henn, Fritz (East Patchogue, NY)

    2012-01-24

    Methods for treatment of depression-related mood disorders in mammals, particularly humans are disclosed. The methods of the invention include administration of compounds capable of enhancing glutamate transporter activity in the brain of mammals suffering from depression. ATP-sensitive K.sup.+ channel openers and .beta.-lactam antibiotics are used to enhance glutamate transport and to treat depression-related mood disorders and depressive symptoms.

  17. Method of treating depression

    Henn, Fritz

    2013-04-09

    Methods for treatment of depression-related mood disorders in mammals, particularly humans are disclosed. The methods of the invention include administration of compounds capable of enhancing glutamate transporter activity in the brain of mammals suffering from depression. ATP-sensitive K.sup.+ channel openers and .beta.-lactam antibiotics are used to enhance glutamate transport and to treat depression-related mood disorders and depressive symptoms.

  18. Protocol for a randomised controlled trial investigating self-help email messages for sub-threshold depression: the Mood Memos study

    Mackinnon Andrew J.; Jorm Anthony F; Morgan Amy J

    2011-01-01

    Abstract Background Sub-threshold depression is common, impairs functioning, and increases the risk of developing major depression. Although psychological treatments have been investigated for sub-threshold depression, they are costly. A less costly alternative could be an educational health promotion campaign about effective self-help for depression symptoms. The aim of the study is to test the efficacy of a low-cost email-based mental health promotion campaign in changing self-help behaviou...

  19. A randomised, feasibility trial of a tele-health intervention for Acute Coronary Syndrome patients with depression ('MoodCare'): Study protocol

    Hare David L; Atherton John; Hollingsworth Bruce; Forbes Andrew; Sanderson Kristy; Chan Bianca; Hawkes Anna L; O'Neil Adrienne; Jelinek Michael; Eadie Kathy; Taylor C Barr; Oldenburg Brian

    2011-01-01

    Abstract Background Coronary heart disease (CHD) and depression are leading causes of disease burden globally and the two often co-exist. Depression is common after Myocardial Infarction (MI) and it has been estimated that 15-35% of patients experience depressive symptoms. Co-morbid depression can impair health related quality of life (HRQOL), decrease medication adherence and appropriate utilisation of health services, lead to increased morbidity and suicide risk, and is associated with poor...

  20. Mood disorder with mixed, psychotic features due to vitamin b12 deficiency in an adolescent: case report.

    Tufan, Ali Evren; Bilici, Rabia; Usta, Genco; Erdoğan, Ayten

    2012-01-01

    Vitamin B12 is one of the essential vitamins affecting various systems of the body. Reports of psychiatric disorders due to its deficiency mostly focus on middle aged and elderly patients. Here we report a case of vitamin B 12 deficiency in a 16-year old, male adolescent who presented with mixed mood disorder symptoms with psychotic features. Chief complaints were "irritability, regressive behavior, apathy, crying and truancy" which lasted for a year. Premorbid personality was unremarkable with no substance use/exposure or infections. No stressors were present. The patient was not vegetarian. Past medical history and family history was normal. Neurological examination revealed glossitis, ataxia, rigidity in both shoulders, cog-wheel rigidity in the left elbow, bilateral problems of coordination in cerebellar examination, reduced swinging of the arms and masked face. Romberg's sign was present. Laboratory evaluations were normal. Endoscopy and biopsy revealed atrophy of the gastric mucosa with Helicobacter Pylori colonization. Schilling test was suggestive of malabsorbtion. He was diagnosed with Mood disorder with Mixed, Psychotic Features due to Vitamin B12 Deficiency and risperidone 0.5 mg/day and intramuscular vitamin B12 500 mcg/day were started along with referral for treatment of Helicobacter pylori. A visit on the second week revealed no psychotic features. Romberg's sign was negative and cerebellar tests were normal. Extrapyramidal symptoms were reduced while Vitamin B12 levels were elevated. Risperidone was stopped and parenteral Vitamin B12 treatment was continued with monthly injections for 3 months. Follow-up endoscopy and biopsy at the first month demonstrated eradication of H. pylori. He was followed monthly for another 6 months and psychiatric symptoms did not recur at the time of last evaluation. Despite limitations, this case may underline the observation that mood disorders with psychotic features especially with accompanying extrapyramidal symptoms lacking a clear etiology may be rare manifestation of vitamin B12 and/or folate deficiency in children and adolescents and be potentially amenable to treatment. PMID:22726236

  1. Mood disorder with mixed, psychotic features due to vitamin b12 deficiency in an adolescent: case report

    Tufan Ali

    2012-06-01

    Full Text Available Abstract Vitamin B12 is one of the essential vitamins affecting various systems of the body. Reports of psychiatric disorders due to its deficiency mostly focus on middle aged and elderly patients. Here we report a case of vitamin B 12 deficiency in a 16-year old, male adolescent who presented with mixed mood disorder symptoms with psychotic features. Chief complaints were “irritability, regressive behavior, apathy, crying and truancy” which lasted for a year. Premorbid personality was unremarkable with no substance use/exposure or infections. No stressors were present. The patient was not vegetarian. Past medical history and family history was normal. Neurological examination revealed glossitis, ataxia, rigidity in both shoulders, cog-wheel rigidity in the left elbow, bilateral problems of coordination in cerebellar examination, reduced swinging of the arms and masked face. Romberg’s sign was present. Laboratory evaluations were normal. Endoscopy and biopsy revealed atrophy of the gastric mucosa with Helicobacter Pylori colonization. Schilling test was suggestive of malabsorbtion. He was diagnosed with Mood disorder with Mixed, Psychotic Features due to Vitamin B12 Deficiency and risperidone 0.5 mg/day and intramuscular vitamin B12 500 mcg/day were started along with referral for treatment of Helicobacter pylori. A visit on the second week revealed no psychotic features. Romberg’s sign was negative and cerebellar tests were normal. Extrapyramidal symptoms were reduced while Vitamin B12 levels were elevated. Risperidone was stopped and parenteral Vitamin B12 treatment was continued with monthly injections for 3 months. Follow-up endoscopy and biopsy at the first month demonstrated eradication of H. pylori. He was followed monthly for another 6 months and psychiatric symptoms did not recur at the time of last evaluation. Despite limitations, this case may underline the observation that mood disorders with psychotic features especially with accompanying extrapyramidal symptoms lacking a clear etiology may be rare manifestation of vitamin B12 and/or folate deficiency in children and adolescents and be potentially amenable to treatment.

  2. Depressants

    Drug Fact Sheet Depressants Overview Includes barbiturates (barbs), benzodiazepines (benzos) and sedative-hypnotics. Depressants will put you ... unsafe, increasing the likelihood of coma or death. Benzodiazepines were developed to replace barbiturates, though they still ...

  3. Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

    FlĂĄvia de L. OsĂłrio

    2015-03-01

    Full Text Available Objectives: Ayahuasca (AYA, a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D, the Montgomery-Åsberg Depression Rating Scale (MADRS, and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS. AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. Conclusions: These results suggest that AYA has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder.

  4. Post-vasectomy depression: a case report and literature review

    Subahani Shaik

    2014-09-01

    Full Text Available Vasectomy is a commonly performed and relatively safe procedure, with low reported rates of psychological morbidity, though there is some variability across studies. Depression following a vasectomy is relatively infrequent. A married man aged 30 developed a chronic depressive episode, lasting four years and resistant to an adequate trial of fluoxetine, following a vasectomy. His depression was heralded by a post-operative panic attack, and was accompanied by medically unexplained symptoms and the attribution of all his symptoms to the procedure – a belief that was shared by his family. Psychological complications of vasectomy have generally been studied under four heads: sexual dysfunction, effects on marital relationships, chronic post-operative pain, and other complications including anxiety and depression. These complications have generally been reported at higher rates in developing countries, and are linked to poor knowledge about the procedure and inadequate pre-operative counseling. The implications of the existing literature for the patient’s current complaints, and the mechanisms and risk factors involved, are discussed in the light of existing research. Suggestions for the prevention and treatment of post-vasectomy depression are also outlined.

  5. Post-vasectomy depression: a case report and literature review.

    Shaik, Subahani; Rajkumar, Ravi Philip

    2014-09-01

    Vasectomy is a commonly performed and relatively safe procedure, with low reported rates of psychological morbidity, though there is some variability across studies. Depression following a vasectomy is relatively infrequent. A married man aged 30 developed a chronic depressive episode, lasting four years and resistant to an adequate trial of fluoxetine, following a vasectomy. His depression was heralded by a post-operative panic attack, and was accompanied by medically unexplained symptoms and the attribution of all his symptoms to the procedure - a belief that was shared by his family. Psychological complications of vasectomy have generally been studied under four heads: sexual dysfunction, effects on marital relationships, chronic post-operative pain, and other complications including anxiety and depression. These complications have generally been reported at higher rates in developing countries, and are linked to poor knowledge about the procedure and inadequate pre-operative counseling. The implications of the existing literature for the patient's current complaints, and the mechanisms and risk factors involved, are discussed in the light of existing research. Suggestions for the prevention and treatment of post-vasectomy depression are also outlined. PMID:25553234

  6. Depression

    Cizza, G; Ravn, Pernille; Chrousos, G P; Gold, P W

    2001-01-01

    Existing studies of the relationship between depression and osteoporosis have been heterogeneous in their design and use of diagnostic instruments for depression, which might have contributed to the different results on the comorbidity of these two conditions. Nevertheless, these studies reveal a...... strong association between depression and osteoporosis. Endocrine factors such as depression-induced hypersecretion of corticotropin-releasing hormone and hypercortisolism, hypogonadism, growth hormone deficiency and increased concentration of circulating interleukin 6, might play a crucial role in the...... bone loss observed in subjects suffering from major depression....

  7. Music Shifts Frontal EEG in Depressed Adolescents.

    Field, Tiffany; Martinez, Alex; Nawrocki, Thomas; Pickens, Jeffrey; Fox, Nathan A.; Schanberg, Saul

    1998-01-01

    Fourteen chronically depressed female adolescents listened to rock music for a 23-minute session. EEG was recorded and saliva samples were collected to determine the effects of the music on stress hormone cortisol levels. No differences were reported for mood state; however, cortisol levels decreased and relative right-frontal activation was


  8. Mood changes following modern-dance classes

    Lane, Andrew M; Hewston, Ruth M.; Redding, Emma; Whyte, Gregory P

    2003-01-01

    Full-time dancers typically spend a large proportion of time participating in dance classes. The present study examined mood state changes following two contrasting modern-dance styles on a sample of full-time dancers. Twenty-three dancers completed the Brunel University Mood Scale (Terry, Lane, Lane, & Keohane, 1999) to assess anger, confusion, depression, fatigue, tension, and vigor before and after two different dance classes. One class taught was the Jose Limon technique style, characteri...

  9. Adjunctive Triple Chronotherapy (Combined Total Sleep Deprivation, Sleep Phase Advance, and Bright Light Therapy) Rapidly Improves Mood and Suicidality in Suicidal Depressed Inpatients: An Open Label Pilot Study

    Sahlem, Gregory L.; Kalivas, Benjamin; Fox, James B.; Lamb, Kayla; Roper, Amanda; Williams, Emily N.; Williams, Nolan R; Korte, Jeffrey E; Zuschlag, Zachary D.; El Sabbagh, Salim; Guille, Constance; Barth, Kelly S.; Uhde, Thomas W.; George, Mark S.; Short, E. Baron

    2014-01-01

    Previous studies have demonstrated that combined total sleep deprivation (Wake therapy), sleep phase advance, and bright light therapy (Triple Chronotherapy) produce a rapid and sustained antidepressant effect in acutely depressed individuals. To date no studies have explored the impact of the intervention on unipolar depressed individuals with acute concurrent suicidality. Participants were suicidal inpatients (N=10, Mean age=44±16.4SD, 6F) with unipolar depression. In addition to standard o...

  10. Adolescent coping profiles differentiate reports of depression and anxiety symptoms.

    Herres, Joanna

    2015-11-01

    The purpose of the study was to identify groups of adolescents based on their reported use of different coping strategies and compare levels of depression and anxiety symptoms across the groups. Tenth and eleventh grade public school students (N=982; 51% girls; 66% Caucasian; M age=16.04, SD=0.73) completed a battery of self-report measures that assessed their use of different coping strategies, depressive symptoms, and anxiety symptoms. Latent profile analysis (LPA) classified the participants into four distinct groups based on their responses on subscales of the COPE inventory (Carver et al., 1989). Groups differed in amount of coping with participants in each group showing relative preference for engaging in certain strategies over others. Disengaged copers reported the lowest amounts of coping with a preference for avoidance strategies. Independent copers reported moderate levels of coping with relatively less use of support-seeking. Social support-seeking copers and active copers reported the highest levels of coping with a particular preference for support-seeking strategies. The independent copers reported the lowest levels of depressive symptoms compared to the three other groups. The Social Support Seeking and Active Coping Groups reported the highest levels of anxiety. Although distinct coping profiles were observed, findings showed that adolescents between the ages of 14 and 16 engage in multiple coping strategies and are more likely to vary in their amount of coping than in their use of specific strategies. PMID:26275359

  11. Hypomania spectrum disorder in adolescence : a 15-year follow-up of non-mood morbidity in adulthood

    Päären, Aivar; Bohman, Hannes; von Knorring, Anne-Liis; von Knorring, Lars; Olsson, Gunilla; Jonsson, Ulf

    2014-01-01

    Background: We investigated whether adolescents with hypomania spectrum episodes have an excess risk of mental and physical morbidity in adulthood, as compared with adolescents exclusively reporting major depressive disorder (MDD) and controls without a history of adolescent mood disorders. Methods: A community sample of adolescents (N = 2 300) in the town of Uppsala, Sweden, was screened for depressive symptoms. Both participants with positive screening and matched controls (in total 631) we...

  12. Depression

    ... mania may include agitation, confusion, hallucinations, or delusions. Schizophrenia that does not respond to medication. Tips on getting through depression DO: Pace yourself. Get involved in activities that ...

  13. Clinical and psychopatological features of organic depressive disorder in the individual abusing alcohol (case report

    Spirina I.D.

    2015-03-01

    Full Text Available The article describes a clinical case of organic depressive disorder in the personality who sustained a traumatic brain injury and who abused alcohol, with distinguishing number of clinical and psychopathological features. Depressed mood, slowed thinking process, sleep disturbances, low self-esteem, hypochondriacal tendencies allowed to diagnose depressive disorder. Clinical history on sustained brain concussion, as well as inertness of nervous and mental processes revealed in psychodiagnostic study testified to organic genesis of the disease. Alcohol abuse by the person having an adverse organic background contributed to appearance of psychotic symptoms in clinical picture. Hallucinatory and delusional inclusions relatively quickly stopped on a background of antipsychotic treatment; this testified that they are secondary to the affective (depressive symptoms.

  14. The Relationship between Mood State, Interpersonal Attitudes and Psychological Distress in Stroke Patients

    Turner, Margaret A.; Andrewes, David G.

    2010-01-01

    This study investigated whether increasing positive mood improved interpersonal attitudes and relieved depression in depressed stroke patients despite levels of cognitive and emotional dysfunction. Depressed stroke (n = 30) and rheumatic/orthopaedic controls (n = 30) were compared on the effect of verbal and nonverbal positive and neutral mood…

  15. Lithium safety and tolerability in mood disorders: a critical review

    Ivan Aprahamian

    2014-04-01

    Full Text Available Background : Lithium is a first-line treatment for bipolar disorder in all phases, also indicated as add-on drug for unipolar depression and suicide prevention. This study encompasses a broad critical review on the safety and tolerability of lithium for mood disorders. Methods : A computerized search for English written human studies was made in MEDLINE, using the keywords “lithium” and “mood disorders”, starting from July 1993 through July 2013 (n = 416. This initial search aimed to select clinical trials, prospective data, and controlled design studies of lithium treatment for mood disorders reporting adverse effects (n = 36. The final selection yielded 91 studies. Results : The most common general side effects in patients on lithium treatment were thirst, frequent urination, dry mouth, weight gain, fatigue and cognitive complaints. Lithium users showed a high prevalence of hypothyroidism, hyperparathyroidism, and decrease in urinary concentration ability. Reduction of glomerular filtration rate in patients using lithium was also observed, but in a lesser extent. The evidence of teratogenicity associated with lithium use is not well established. Anti-inflammatory non-steroidal drugs, thiazide diuretics, angiotensin-converting enzyme inhibitors, and alprazolam may increase serum lithium and the consequent risk for intoxication. Discussion : Short-term lithium treatment is associated with mild side effects. Medium and long-term lithium treatment, however, might have effects on target organs which may be prevented by periodical monitoring. Overall, lithium is still a safe option for the treatment of mood disorders.

  16. Retinoid-mediated regulation of mood: possible cellular mechanisms.

    O'Reilly, Kally; Bailey, Sarah J; Lane, Michelle A

    2008-03-01

    Vitamin A and its derivatives, the retinoids, have long been studied for their ability to alter central nervous system (CNS) development. Increasingly, it is recognized that sufficient levels of retinoids may also be required for adult CNS function. However, excess dietary vitamin A, due to the consumption of supplements or foods rich in vitamin A, has been reported to induce psychosis. In addition, 13-cis-retinoic acid (13-cis-RA, isotretinoin), the active ingredient in the acne treatment Accutane, has been reported to cause adverse psychiatric events, including depression and suicidal ideation. Nevertheless, epidemiological studies have reported no consistent link between Accutane use and clinical depression in humans. Using an animal model, we have recently shown that 13-cis-RA induces an increase in depression-related behavior. Impairments in spatial learning and memory have also been demonstrated following 13-cis-RA treatment in mice. This review focuses on the behavioral and possible cellular effects of retinoid deficiency or excess in the adult brain in relation to altered mood. Specifically, we discuss the effect of retinoids on depression-related behaviors and whether norepinephrinergic, dopaminergic, or serotonergic neurotransmitter systems may be impaired. In addition, we consider the evidence that adult neurogenesis, a process implicated in the pathophysiology of depression, is reduced by retinoid signaling. We suggest that 13-cis-RA treatment may induce depression-related behaviors by decreasing adult neurogenesis and/or altering the expression of components of serotonergic neurotransmitter system, thereby leading to impaired serotonin signaling. PMID:18296731

  17. Depression.

    Strock, Margaret

    Approximately ten percent of the population suffers from a depressive illness each year. Although the economic cost is high, the cost in human suffering is immeasurable. To help educate the population about this disorder, this paper presents a definition of depression and its common manifestations. The symptoms that people often experience are


  18. Depression

    ... also can have side effects that contribute to depression. Children with depression may pretend to be sick, refuse to go to school, cling to a parent, or worry that a parent may die. Older children or teens may get into trouble at school ...

  19. Depression

    Johansen, Jon O. J.

    2013-01-01

    Nyhederne er fulde af historier om depression. Overskrifter som: ’Danskerne propper sig med lykkepiller’ eller ‘depression er stadigvĂŠk tabu’ gĂ„r tit igen i dagspressen. Men hvor er nuancerne, og hvorfor gider vi lĂŠse de samme historier igen og igen? MĂ„ske er det fordi, vores egne forestillinger er...

  20. The influence of rumination and distraction on depressed and anxious mood: a prospective examination of the response styles theory in children and adolescents.

    Roelofs, Jeffrey; Rood, Lea; Meesters, Cor; te Dorsthorst, Valérie; Bögels, Susan; Alloy, Lauren B; Nolen-Hoeksema, Susan

    2009-10-01

    The present study sought to test predictions of the response styles theory in a sample of children and adolescents. More specifically, a ratio approach to response styles was utilized to examine the effects on residual change scores in depression and anxiety. Participants completed a battery of questionnaires including measures of rumination, distraction, depression, and anxiety at baseline (Time 1) and 8-10 weeks follow-up (Time 2). Results showed that the ratio score of rumination and distraction was significantly associated with depressed and anxious symptoms over time. More specifically, individuals who have a greater tendency to ruminate compared to distracting themselves have increases in depression and anxiety scores over time, whereas those who have a greater tendency to engage in distraction compared to rumination have decreases in depression and anxiety symptoms over time. These findings indicate that a ratio approach can be used to examine the relation between response styles and symptoms of depression and anxiety in non-clinical children and adolescents. Implications of the results may be that engaging in distractive activities should be promoted and that ruminative thinking should be targeted in juvenile depression treatment. PMID:19415414

  1. The influence of rumination and distraction on depressed and anxious mood: a prospective examination of the response styles theory in children and adolescents

    Roelofs, Jeffrey; Rood, Lea; Meesters, Cor; Dorsthorst, Valérie; Bögels, Susan; Alloy, Lauren B.; Nolen-Hoeksema, Susan

    2009-01-01

    Abstract The present study sought to test predictions of the response styles theory in a sample of children and adolescents. More specifically, a ratio approach to response styles was utilized to examine the effects on residual change scores in depression and anxiety. Participants completed a battery of questionnaires including measures of rumination, distraction, depression, and anxiety at baseline (Time 1) and 8?10 weeks follow-up (Time 2). Results showed that the ratio score of ...

  2. Colour fluctuations in grapheme-colour synaesthesia: The effect of clinical and non-clinical mood changes.

    Kay, Collette L; Carmichael, Duncan A; Ruffell, Henry E; Simner, Julia

    2015-08-01

    Synaesthesia is a condition that gives rise to unusual secondary sensations (e.g., colours are perceived when listening to music). These unusual sensations tend to be reported as being stable throughout adulthood (e.g., Simner & Logie, 2007, Neurocase, 13, 358) and the consistency of these experiences over time is taken as the behavioural hallmark of genuineness. Our study looked at the influence of mood states on synaesthetic colours. In Experiment 1, we recruited grapheme-colour synaesthetes (who experience colours from letters/digits) and elicited their synaesthetic colours, as well as their mood and depression states, in two different testing sessions. In each session, participants completed the PANAS-X (Watson & Clark, 1999) and the BDI-II (Beck, Steer, & Brown, 1996, Manual for Beck Depression Inventory-II), and chose their synaesthetic colours for letters A-Z from an interactive colour palette. We found that negative mood significantly decreased the luminance of synaesthetic colours. In Experiment 2, we showed that synaesthetic colours were also less luminant for synaesthetes with anxiety disorder, versus those without. Additional evidence suggests that colour saturation, too, may inversely correlate with depressive symptoms. These results show that fluctuations in mood within both a normal and clinical range influence synaesthetic colours over time. This has implications for our understanding about the longitudinal stability of synaesthetic experiences, and of how mood may interact with the visual (imagery) systems. PMID:25413977

  3. Influence of postpartum onset on the course of mood disorders

    Olgiati Paolo

    2006-01-01

    Full Text Available Abstract Background To ascertain the impact of postpartum onset (PPO on the subsequent time course of mood disorders. Methods This retrospective study compared per year rates of excited (manic or mixed and depressive episodes between fifty-five women with bipolar (N = 22 or major depressive (N = 33 disorders with first episode occurring postpartum (within four weeks after childbirth according to DSM-IV definition and 218 non-postpartum onset (NPPO controls. Such patients had a traceable illness course consisting of one or more episodes alternating with complete symptom remission and no additional diagnoses of axis I disorders, mental retardation or brain organic diseases. A number of variables reported to influence the course of mood disorders were controlled for as possible confounding factors Results Bipolar women with postpartum onset disorder had fewer excited episodes (p = 0.005 and fewer episodes of both polarities (p = 0.005 compared to non-postpartum onset subjects. No differences emerged in the rates of depressive episodes. All patients who met criteria for rapid cycling bipolar disorder (7 out of 123 were in the NPPO group. Among major depressives, PPO patients experienced fewer episodes (p = 0.016. With respect to clinical and treatment features, PPO-MDD subjects had less personality disorder comorbidity (p = 0.023 and were less likely to be on maintenance treatment compared to NPPO comparison subjects (p = 0.002 Conclusion Such preliminary findings suggest that PPO mood disorders may be characterized by a less recurrent time course. Future research in this field should elucidate the role of comorbid personality disorders and treatment. Moreover it should clarify whether PPO disorders are also associated with a more positive outcome in terms of social functioning and quality of life.

  4. Circadian Genes, Rhythms and the Biology of Mood Disorders

    McClung, Colleen A.

    2007-01-01

    For many years, researchers have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders such as bipolar disorder, major depression and seasonal affective disorder. Furthermore, some of the treatments that are currently employed to treat mood disorders are thought to act by shifting or “resetting” the circadian clock, including total sleep deprivation and bright light therapy. There is also reason to suspect that many of the mood stabilizers and antide...

  5. Mood Disorders Are Glial Disorders: Evidence from In Vivo Studies

    Karsten Mueller; Blasig, Ingolf E.; Johann Steiner; Hashim Abdul-Khaliq; Julia Sacher; Matthias L. Schroeter

    2010-01-01

    It has recently been suggested that mood disorders can be characterized by glial pathology as indicated by histopathological postmortem findings. Here, we review studies investigating the glial marker S100B in serum of patients with mood disorders. This protein might act as a growth and differentiation factor. It is located in, and may actively be released by, astro- and oligodendrocytes. Studies consistently show that S100B is elevated in mood disorders; more strongly in major depressive tha...

  6. Providers' Attitudes Towards Treating Depression and Self-Reported Depression Treatment Practices in HIV Outpatient Care

    Bess, Kiana D.; Adams, Julie; Watt, Melissa. H.; O'Donnell, Julie K.; Gaynes, Bradley N.; Thielman, Nathan M.; Heine, Amy; Zinski, Anne; James L. Raper; Pence, Brian W

    2013-01-01

    Depression is highly prevalent among HIV-infected patients, yet little is known about the quality of HIV providers' depression treatment practices. We assessed depression treatment practices of 72 HIV providers at three academic medical centers in 2010–2011 with semi-structured interviews. Responses were compared to national depression treatment guidelines. Most providers were confident that their role included treating depression. Providers were more confident prescribing a first antidepress...

  7. Depressants

    ... effects include: impaired sexual function insomnia and other sleep problems breathing problems convulsions (similar to seizures) depression and other mental health issues continue Other Possible Problems Taking too much ...

  8. Recent progress in mood disorder research

    When papers published in highly-prestigious journals in 2010 and 2011 were categorized, the number of papers on genestic studies was found to be the largest, followed by papers on brain imaging, postmortem brain studies, and animal model studies. Follow-up studies of the findings of initial genome-wide association analyses constitute a major part of genetic studies. Recent brain imaging studies were found to integrate previous findings that indicated altered responces of prefrontal cortex to cognitive stimuli and enhanced responces of amygdala to emotional faces. Reduced size of the hippocampus is reportedly not a result of stress but perhaps a vulnerability factor. Among animal model studies, molecular mechanisms underlying rapid anti-depressive effects of ketamine are drawing attention. The role of neurogenesis in fear memory and depression is complex, and a link between psychopathology and neuroscience may be needed to understand the roles of neurogenesis. Postmortem brain analyses are currently used to investigate several pathophysiological hypotheses related to the roles of monoamine, neuroplasticity, and neuroinflammation in depression, as well as the roles of gamma-aminobutyric acid (GABA)ergic neurons and mitochondria in bipolar disorder. Several studies are integrating postmortem brain analysis and animal model studies. Genetic and neuroimaging studies of mood disorders have advanced, and neurobiological basis of the findings of these studies should be further elucidated in animal models and postmortem brains. (author)

  9. [Recent progress in mood disorder research].

    Kato, Tadafumi

    2012-02-01

    When papers published in highly-prestigious journals in 2010 and 2011 were categorized, the number of papers on genestic studies was found to be the largest, followed by papers on brain imaging, postmortem brain studies, and animal model studies. Follow-up studies of the findings of initial genome-wide association analyses constitute a major part of genetic studies. Recent brain imaging studies were found to integrate previous findings that indicated altered responces of prefrontal cortex to cognitive stimuli and enhanced responces of amygdala to emotional faces. Reduced size of the hippocampus is reportedly not a result of stress but perhaps a vulnerability factor. Among animal model studies, molecular mechanisms underlying rapid anti-depressive effects of ketamine are drawing attention. The role of neurogenesis in fear memory and depression is complex, and a link between psychopathology and neuroscience may be needed to understand the roles of neurogenesis. Postmortem brain analyses are currently used to investigate several pathophysiological hypotheses related to the roles of monoamine, neuroplasticity, and neuroinflammation in depression, as well as the roles of GABAergic neurons and mitochondria in bipolar disorder. Several studies are integrating postmortem brain analysis and animal model studies. Genetic and neuroimaging studies of mood disorders have advanced, and neurobiological basis of the findings of these studies should be further elucidated in animal models and postmortem brains. PMID:22308257

  10. Ups and Downs: Daily Cycles of Adolescent Moods.

    Barber, Bonnie L.; Jacobson, Kristen C.; Miller, Kristelle E.; Petersen, Anne C.

    1998-01-01

    Examined diurnal patterns of adolescents' stress, affect, and arousal. Found that gender, depression risk status, and day of week influenced mean levels of adolescent moods but were not associated with differences in mood patterns throughout the day. Suggested that adolescents' emotional states follow a diurnal cycle stemming from endogenous


  11. Acute Psychosis and Depression Associated with Hypercalcemia: A Case Report

    Halil ÖZCAN

    2013-03-01

    Full Text Available Psychosis and depression are mental disorders that can exist secondary to some medical disorders and may be associated with the use of drugs. The most frequent causes of these disorders are substance abuse, infections (especially central nervous system infections, hormone or collagen tissue disorders, cancer, and side effect of drugs used to treat diseases. Hypercalcemia is referred as high level of calcium in the blood - higher than 10,2 mg/dl - and is often seen with parathyroid adenoma. Hypercalcemia may cause several symptoms. In this case report, we represent the case of a patient who presented with delusion of persecution and depressive symptoms probably secondary to hypercalcemia. (Arc­hi­ves of Neu­ropsy­chi­atry 2013;50: 75-77

  12. Transtornos do humor em enfermaria de clínica médica e validação de escala de medida (HAD de ansiedade e depressão Mood disorders among medical in-patients: a validation study of the hospital anxiety and depression scale (HAD

    Neury J. Botega

    1995-10-01

    Full Text Available Para estimar a prevalĂȘncia de transtornos do humor, foram utilizadas a entrevista estruturada, "Clinical Interview Schedule" (CIS-R, e a escala "Hospital Anxiety and Depression" (HAD em 78 pacientes internados em uma enfermaria geral de adultos (43 homens e 35 mulheres, mĂ©dia de idade = 43,2 anos. Foi encontrada prevalĂȘncia instantĂąnea de 39% de transtornos do humor. Dezesseis (20,5% pacientes preencheram critĂ©rios para ansiedade, a maioria dos casos sendo de gravidade leve. Vinte e seis (33% casos de depressĂŁo foram detectados, 7 dos quais de gravidade moderada. Observou-se uma combinação de sintomas de preocupação, depressĂŁo, ansiedade e insĂŽnia. A HAD mostrou-se de fĂĄcil compreensĂŁo pelos pacientes. As subescalas de ansiedade e de depressĂŁo tiveram consistĂȘncia interna de 0,68 e 0,77, respectivamente. A correlação dos itens com as respectivas subescalas sugere que essas possuem validades convergentes, nĂŁo discriminantes. Com ponto de corte 8/9, a sensibilidade e a especificidade foram 93,7% e 72,6%, para ansiedade, e 84,6% e 90,3%, para depressĂŁo. Na prĂĄtica clĂ­nica, a utilização da HAD poderia auxiliar na detecção de casos de transtornos do humor que necessitam de tratamento.The revised Clinical Interview Schedule (CIS-R and the Hospital Anxiety and Depression (HAD Scale were used to estimate the prevalence of mood disorders among 78 consecutive admissions to a general medical ward in a university general hospital in Brazil (43 males and 35 females; mean age = 43.2yr. Interviewers also completed a 5-point symptom severity scales for anxiety and depression. The definition of cases of anxiety [and depression] was based on two criteria: a. score > 2 on the CIS-R section of anxiety [> 4 on the CIS-R sections of depression and depressive ideas]; and b. score > 2 on the clinical severity scale for anxiety [score > 2 on the clinical severity scale for depression]. A 39% prevalence rate of affective disorders was found. Sixteen (20.5% patients met criteria for anxiety, most of the disorders being of mild severity. Twenty-sic patients (33% were depressed, 7 of them in a moderate degree. The HAD was easily understood by the patients. Anxiety and depression subscales had internal consistency of 0.68 and 0.77, respectively. At a cut-off point of 8/9 sensibility and specificity were 93.7% and 72.6% for anxiety, and 84.6% and 90.3% for depression. HAD items correlated positively with the respective subscales. To a lesser degree, they also correlated with the alternative subscale. Our findings confirm the high prevalence of mood disorders among medical in-patients. In clinical practice, the HAD may have a useful role in detecting those patients requiring further psychological care.

  13. Erythropoietin improves mood and modulates the cognitive and neural processing of emotion 3 days post administration.

    Miskowiak, Kamilla; Inkster, Becky; Selvaraj, Sudhakar; Wise, Richard; Goodwin, Guy M; Harmer, Catherine J

    2008-02-01

    Erythropoietin (Epo) has neuroprotective and neurotrophic effects and is a promising candidate for treatment of neurodegenerative and psychiatric disorder. Recently, we demonstrated that Epo modulates memory-relevant hippocampal response and fear processing in human models of antidepressant drug action 1 week post-administration, and improves self-reported mood for 3 days immediately following administration. The present study explored the effects of Epo (40 000 IU) vs saline on self-reported mood and on neural and cognitive function in healthy volunteers 3 days post-administration to test the reliability of the rapid mood improvement and its neuropsychological basis. Neuronal responses during the processing of happy and fearful faces were investigated using functional magnetic resonance imaging (fMRI); facial expression recognition performance was assessed after the fMRI scan. Daily ratings of mood were obtained for 3 days after Epo/saline administration. During faces processing Epo enhanced activation in the left amygdala and right precuneus to happy and fearful expressions. This was paired with improved recognition of all facial expressions, in particular of low intensity happiness and fear. This is similar to behavioral effects observed with acute administration of serotonergic antidepressants. Consistent with our previous finding, Epo improved self-reported mood for all 3 days post-administration. Together, these results suggest that characterization of the effects of Epo in a clinically depressed group is warranted. PMID:17473836

  14. The increasing burden of depression.

    LĂ©pine, Jean-Pierre; Briley, Mike

    2011-01-01

    Recent epidemiological surveys conducted in general populations have found that the lifetime prevalence of depression is in the range of 10% to 15%. Mood disorders, as defined by the World Mental Health and the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, have a 12-month prevalence which varies from 3% in Japan to over 9% in the US. A recent American survey found the prevalence of current depression to be 9% and the rate of current major depression to be 3.4%. All studies of depressive disorders have stressed the importance of the mortality and morbidity associated with depression. The mortality risk for suicide in depressed patients is more than 20-fold greater than in the general population. Recent studies have also shown the importance of depression as a risk factor for cardiovascular death. The risk of cardiac mortality after an initial myocardial infarction is greater in patients with depression and related to the severity of the depressive episode. Greater severity of depressive symptoms has been found to be associated with significantly higher risk of all-cause mortality including cardiovascular death and stroke. In addition to mortality, functional impairment and disability associated with depression have been consistently reported. Depression increases the risk of decreased workplace productivity and absenteeism resulting in lowered income or unemployment. Absenteeism and presenteeism (being physically present at work but functioning suboptimally) have been estimated to result in a loss of $36.6 billion per year in the US. Worldwide projections by the World Health Organization for the year 2030 identify unipolar major depression as the leading cause of disease burden. This article is a brief overview of how depression affects the quality of life of the subject and is also a huge burden for both the family of the depressed patient and for society at large. PMID:21750622

  15. [The modern concept of atypical depression: four definitions].

    Ohmae, Susumu

    2010-01-01

    This report describes and compares four current concepts and definitions of atypical depression. Since its emergence, atypical depression has been considered a depressive state that can be relieved by MAO inhibitors. Davidson classified the symptomatic features of atypical depression into type A, which is predominated by anxiety symptoms, and type V, which is represented by atypical vegetative symptoms, such as hyperphagia, weight gain, oversleeping, and increased sexual drive. Features that are shared by both subtypes include: early onset, female predominance, outpatient predominance, mildness, few suicide attempts, nonbipolarity, nonendogeneity, and few psychomotor changes. Based on these features, bipolar depression can also be defined as atypical depression type V. Herein, we examine and classify four concepts of atypical depression according to the endogenous-nonendogenous (melancholic-nonmelancholic) and unipolar-bipolar dichotomies. The Columbia University group (see Quitkin, Stewart, McGrath, Klein et al.) and the New South Wales University group (see Parker) consider atypical depression to be chronic, mild, nonendogenous (nonmelancholic), unipolar depression. The former group postulates that mood reactivity is necessary, while the latter asserts the structural priority of anxiety symptoms over mood symptoms and the significance of interpersonal rejection sensitivity. For the Columbia group, the significance of mood reactivity reflects the theory that mood nonreactivity is the essential symptom of "endogenomorphic depression", which was proposed by Klein as typical depression. Thus, mood reactivity is not related to overreactivity or hyperactivity, which are often observed in atypical depressives. However, Parker postulates that psychomotor symptoms are the essential features of melancholia, which he recognizes as typical depression; therefore, the New South Wales group does not recognize the significance of mood reactivity. The New South Wales group accepts the relationship between anxiety symptoms and interpersonal rejection sensitivity, while the Columbia group does not recognize the importance of anxiety symptoms because they could not identify a relationship between such symptoms and the efficacy of MAO inhibitors. The concept of atypical depression proposed by the New South Wales group overlaps considerably with that of hysteroid dysphoria, which was proposed by Klein et al., and was the progenitor of Columbia group's concept of atypical depression. The Pittsburgh University group (see Himmelhoch, Kupfer, Thase et al.) and the soft bipolar spectrum group (see Akiskal, Perugi, Benazzi et al.) regard atypical depression as a depressive state that can be observed in bipolar disorder. The former groups takes into account reversed vegetative symptoms and lethargy as signs of bipolar disorder, while the latter recognizes that atypical depression shares features with bipolar II disorder or soft bipolar spectrum disorder. The soft bipolar spectrum group maintains their unique concept of bipolar disorder, which regards some unipolar depressions as bipolar disorder, while the Pittsburg group continues to share the conventional concept of a unipolar-bipolar dichotomy with other groups. The fundamental pattern of atypical depression is represented by chronic mild depressions, which are characterized by a younger age at onset, female predominance, interpersonal rejection sensitivity, and mood lability, which are difficult to distinguish from a characterological pathology. Patients who present with such patterns are frequently diagnosed with borderline, histrionic, or avoidant personality disorders; therefore, we must recognize the significance of atypical depression as a concept that can suggest the utility of medication for these patients. For such patients, however, various groups have proposed different kinds of definition and therapeutic guidelines that are difficult to synthesize and utilize in clinical settings. Moreover, some features of atypical depression outlined in the Columbia University criteria, such as a younger age at onset, chronicity, mildness, and female predominance, were excluded from DSM-IV. Consequently, the concept of atypical depression has become overextended and gradually lost its construct validity. Therefore, the diagnostic criteria for atypical depression should be reconsidered in reference to various definitions and concepts and refined through accumulated clinical research. PMID:20184236

  16. Stress and Mood

    ... Relaxation Emotions & Relationships HealthyYouTXT Tools Home » Stress & Mood Stress & Mood Many people who go back to smoking ... story: Time Out Times 10 >> share What Causes Stress? Read full story: What Causes Stress? >> share The ...

  17. Self-Reported versus Informant-Reported Depressive Symptoms in Adults with Mild Intellectual Disability

    Mileviciute, I.; Hartley, S. L.

    2015-01-01

    Background: Virtually nothing is known about potential differences in the types of depression symptoms reported by adults with mild intellectual disability (ID) on self-reported questionnaires as compared with the types of symptoms reported by caregivers on informant questionnaires. Moreover, little is known about how the presentation of


  18. Sleep disorders and depression: brief review of the literature, case report, and nonpharmacologic interventions for depression

    De Luca A; De Luca M.; Calandra C

    2013-01-01

    Antonina Luca,1 Maria Luca,2 Carmela Calandra2 1Department GF Ingrassia, Section of Neuroscience, 2Department of Medical and Surgery Specialties, Psychiatry Unit, University Hospital Policlinico-Vittorio Emanuele, Catania, Sicily, Italy Abstract: Sleep disorders are so frequently associated with depression that, in the absence of sleep complaints, a diagnosis of depression should be made with caution. Insomnia, in particular, may occur in 60%–80% of depressed patients. Depressive sympto...

  19. Electrophysiological evidence of the time course of attentional bias in nonpatients reporting symptoms of depression with and without co-occurring anxiety

    SarahM.Sass

    2014-04-01

    Full Text Available Anxiety is characterized by attentional biases to threat, but findings are inconsistent for depression. To address this inconsistency, the present study systematically assessed the role of co-occurring anxiety in attentional bias in depression. In addition, the role of emotional valence, arousal, and gender was explored. Ninety-two nonpatients completed the Penn State Worry Questionnaire (PSWQ; Meyer et al., 1990; Molina & Borkovec, 1994 and portions of the Mood and Anxiety Symptom Questionnaire (MASQ; Watson, Clark, et al., 1995; Watson, Weber, et al., 1995. Individuals reporting high levels of depression and low levels of anxiety (depression only, high levels of depression and anxiety (combined, or low levels of both (control completed an emotion-word Stroop task during event-related brain potential (ERP recording. Pleasant and unpleasant words were matched on emotional arousal level. An attentional bias was not evident in the depression-only group. Women in the combined group had larger N200 amplitude for pleasant than unpleasant stimuli, and the combined group as a whole had larger right-lateralized P300 amplitude for pleasant than unpleasant stimuli, consistent with an early and later attentional bias that is specific to unpleasant valence in the combined group. Men in the control group had larger N200 amplitude for pleasant than unpleasant stimuli, consistent with an early attentional bias that is specific to pleasant valence. The present study indicates that the nature and time course of attention prompted by emotional valence and not arousal differentiates depression with and without anxiety, with some evidence of gender moderating early effects. Overall, results suggest that co-occurring anxiety is more important than previously acknowledged in demonstrating evidence of attentional biases in depression.

  20. Regular group exercise is associated with improved mood but not quality of life following stroke

    Michelle N. McDonnell

    2014-03-01

    Full Text Available Purpose. People with stroke living in the community have an increased prevalence of depression and lower quality of life than healthy older adults. This cross-sectional observational study investigated whether participation in regular exercise was associated with improved mood and quality of life. Methods. We recruited three groups of community dwelling participants: 13 healthy older adults, 17 adults post-stroke who regularly participated in group exercise at a community fitness facility and 10 adults post-stroke who did not regularly exercise. We measured mood using the Depression, Anxiety, Stress Scale (DASS and quality of life using the Assessment of Quality of Life (AQoL scale. Results. Levels of stress and depression were significantly greater in the people with stroke who did not undertake regular exercise (p = 0.004 and p = 0.004 respectively, although this group had more recent strokes (p < 0.001. Both stroke groups had lower quality of life scores (p = 0.04 than the healthy adults. Conclusions. This small, community-based study confirms that people following stroke report poorer quality of life than stroke-free individuals. However, those who exercise regularly have significantly lower stress and depression compared to stroke survivors who do not. Future research should focus on the precise type and amount of exercise capable of improving mood following stroke.

  1. Emerging Novel Treatments for Severe Mood Disorders Involving Cellular Plasticity Cascades

    Machado-Vieira, Rodrigo; Zarate, Carlos A.; MANJI, HUSSEINI K.

    2006-01-01

    Mood disorders are the most prevalent psychiatric disorders. Despite recent advances in the understanding of therapeutically relevant biochemical pathways associated with mood regulation, patients with bipolar disorder and major depression present high rates of recurrences, residual symptoms, and pharmacologic refractoriness. Increasing evidence supports the observations that mood disorders are accompanied by regional brain volumetric reductions accompanied by cellular atrophy/loss. In this p...

  2. Report of three cases that received maintenance treatment with risperidone as a mood stabilizer

    Fountoulakis, Konstantinos N; Nimatoudis, Ioannis; Iacovides, Apostolos; Kaprinis, George

    2004-01-01

    Introduction The current study is a short report of 3 cases of bipolar patients. Material and methods Three bipolar patients were prospectively followed up. All were partial responders to lithium therapy alone, and unresponsive to other therapies (anticonvulsants, antidepressants, typical antipsychotics, various combinations). Results All manifested complete remission of symptoms after combination therapy with lithium (plasma levels above 0.8 mEq/lt) plus 1–3 mg of risperidone daily. The two of them are still free of symptomatology during the maintenance period for 28 and 38 months respectively. The third patient, after several months during which she was free of symptomatology discontinued lithium against the psychiatrist's advise and received only 3 mg of risperidone daily. For the next 15 months the patient was under risperidone monotherapy and free of symptomatology. She discontinued therapy to become pregnant, the illness recurred several times during pregnancy and after the delivery the patient restarted risperidone therapy. She was free of symptoms for the following 9 months until her last follow-up. Discussion The current study provides preliminary evidence concerning the long term efficacy of risperidone in the treatment of bipolar patients PMID:15163347

  3. Depression and inflammation in rheumatic diseases.

    Buras, Aleksandra; Waszkiewicz, Napoleon; Szulc, Agata

    2016-01-01

    It is known that the prevalence of depression in rheumatologic patients is higher than in the general population. Socioeconomic factors are not a sufficient explanation of mood disorder in these patients. Symptoms reported by patients with chronic inflammatory diseases resemble changes defined as "sickness behavior". Mood disorders among somatic patients could be explained by disturbances of the immune system according to the monoaminergic theory of depression. Inflammatory factors such as IL-1 (interleukin-1), IL-2 (interleukin-2), IL-6 (interleukin-6), TNF-? (tumor necrosis factor ?), and IFN-? (interferon-?) act within the CNS (central nervous system). They get through from peripheral tissues as well as being synthesized de novo by neurons. This cytokine activity correlates positively with depression intensity as well as with genetic polymorphism of the serotonin (5-HT) transporter. The theory of glucocorticoid resistance-mediated depression (limbic-hypothalamic-pituitary-adrenal [LHPA] axis) is also connected with gained proinflammatory cytokines activity. It might assume the form of a vicious circle. Depressed mood is probably linked with depression in immune-mediated diseases. An elevated level of proinflammatory cytokines is able to activate IDO (indoleamine 2,3-dioxygenase) - an enzyme catabolizing tryptophan (5-HT precursor). Those reactions probably play the main role at the biochemical level. IDO metabolites extensively disturb neurotransmission. 3-Hydroxykynurenine (3OH-KYN), quinolinic acid (Quin) and kynurenic acid (KYNA) are neurotoxic by releasing oxidative stress mediators. Moreover, they activate MAO (monoamine oxidase), which degrades neurotransmitters responsible for stable mood. Bidirectional communication between the neuroendocrine and immune systems is significant for depression treatment, as well as CNS protection against incremental neurodegeneration among seemingly diverse diseases. PMID:26943313

  4. Depression and inflammation in rheumatic diseases

    Aleksandra Buras

    2016-03-01

    Full Text Available It is known that the prevalence of depression in rheumatologic patients is higher than in the general population. Socioeconomic factors are not a sufficient explanation of mood disorder in these patients. Symptoms reported by patients with chronic inflammatory diseases resemble changes defined as “sickness behavior”. Mood disorders among somatic patients could be explained by disturbances of the immune system according to the monoaminergic theory of depression. Inflammatory factors such as IL-1 (interleukin-1, IL-2 (interleukin-2, IL-6 (interleukin-6, TNF-α (tumor necrosis factor α, and IFN-Îł (interferon-Îł act within the CNS (central nervous system. They get through from peripheral tissues as well as being synthesized de novo by neurons. This cytokine activity correlates positively with depression intensity as well as with genetic polymorphism of the serotonin (5-HT transporter. The theory of glucocorticoid resistance-mediated depression (limbic-hypothalamic-pituitary-adrenal [LHPA] axis is also connected with gained proinflammatory cytokines activity. It might assume the form of a vicious circle. Depressed mood is probably linked with depression in immune-mediated diseases. An elevated level of proinflammatory cytokines is able to activate IDO (indoleamine 2,3-dioxygenase – an enzyme catabolizing tryptophan (5-HT precursor. Those reactions probably play the main role at the biochemical level. IDO metabolites extensively disturb neurotransmission. 3-Hydroxykynurenine (3OH-KYN, quinolinic acid (Quin and kynurenic acid (KYNA are neurotoxic by releasing oxidative stress mediators. Moreover, they activate MAO (monoamine oxidase, which degrades neurotransmitters responsible for stable mood. Bidirectional communication between the neuroendocrine and immune systems is significant for depression treatment, as well as CNS protection against incremental neurodegeneration among seemingly diverse diseases.

  5. Depression vulnerability: is it really what you think?: understanding the impact of emotion and cognition on the course of depression

    van Rijsbergen, Gerard

    2014-01-01

    Depression is a recurrent disorder. Given the high risk of relapse it is important to study how patients relapse in depression. This thesis, which focused on recurrent depression specifically, showed that it is not so much mood activated dysfunctional thinking patterns that predict relapse in depression, but rather mood itself. Moreover, Preventive Cognitive Therapy, an effective treatment to prevent relapse in depression, did not appear to work through reduction of activation of mood-linked ...

  6. Magnetic seizure therapy in an adolescent with refractory bipolar depression: a case report

    Noda, Yoshihiro; Daskalakis, Zafiris J.; Downar, Jonathan; Croarkin, Paul E.; Fitzgerald, Paul B; Blumberger, Daniel M.

    2014-01-01

    Magnetic seizure therapy (MST) has shown efficacy in adult patients with treatment-resistant depression with limited impairment in memory. To date, the use of MST in adolescent depression has not been reported. Here we describe the first successful use of MST in the treatment of an adolescent patient with refractory bipolar depression. This patient received MST in an ongoing open-label study for treatment-resistant major depression. Treatments employed a twin-coil MST apparatus, with the cent...

  7. Sleep and perinatal mood disorders: a critical review.

    Ross, Lori E; Murray, Brian J; Steiner, Meir

    2005-07-01

    Pregnancy and the postpartum period are recognized as times of vulnerability to mood disorders, including postpartum depression and psychosis. Recently, changes in sleep physiology and sleep deprivation have been proposed as having roles in perinatal psychiatric disorders. In this article we review what is known about changes in sleep physiology and behaviour during the perinatal period, with a focus on the relations between sleep and postpartum "blues," depression and psychosis and on sleep-based interventions for the treatment and prevention of perinatal mood disorders. The interaction between sleep and perinatal mood disorders is significant, but evidence-based research in this field is limited. Studies that measure both sleep and mood during the perinatal period, particularly those that employ objective measurement tools such as polysomnography and actigraphy, will provide important information about the causes, prevention and treatment of perinatal mood disorders. PMID:16049568

  8. Inflamed moods: a review of the interactions between inflammation and mood disorders.

    Rosenblat, Joshua D; Cha, Danielle S; Mansur, Rodrigo B; McIntyre, Roger S

    2014-08-01

    Mood disorders have been recognized by the World Health Organization (WHO) as the leading cause of disability worldwide. Notwithstanding the established efficacy of conventional mood agents, many treated individuals continue to remain treatment refractory and/or exhibit clinically significant residual symptoms, cognitive dysfunction, and psychosocial impairment. Therefore, a priority research and clinical agenda is to identify pathophysiological mechanisms subserving mood disorders to improve therapeutic efficacy. During the past decade, inflammation has been revisited as an important etiologic factor of mood disorders. Therefore, the purpose of this synthetic review is threefold: 1) to review the evidence for an association between inflammation and mood disorders, 2) to discuss potential pathophysiologic mechanisms that may explain this association and 3) to present novel therapeutic options currently being investigated that target the inflammatory-mood pathway. Accumulating evidence implicates inflammation as a critical mediator in the pathophysiology of mood disorders. Indeed, elevated levels of pro-inflammatory cytokines have been repeatedly demonstrated in both major depressive disorder (MDD) and bipolar disorder (BD) patients. Further, the induction of a pro-inflammatory state in healthy or medically ill subjects induces 'sickness behavior' resembling depressive symptomatology. Potential mechanisms involved include, but are not limited to, direct effects of pro-inflammatory cytokines on monoamine levels, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, pathologic microglial cell activation, impaired neuroplasticity and structural and functional brain changes. Anti-inflammatory agents, such as acetyl-salicylic acid (ASA), celecoxib, anti-TNF-α agents, minocycline, curcumin and omega-3 fatty acids, are being investigated for use in mood disorders. Current evidence shows improved outcomes in mood disorder patients when anti-inflammatory agents are used as an adjunct to conventional therapy; however, further research is needed to establish the therapeutic benefit and appropriate dosage. PMID:24468642

  9. Relationship between global cognitive decline and depressive symptoms in multiple sclerosis.

    Barwick, Fiona H; Arnett, Peter A

    2011-02-01

    Cognitive impairment and depressed mood are common symptoms in multiple sclerosis (MS), which significantly impact patients' role functioning and quality of life. Cross-sectional studies indicate a modest association between cognitive impairment and depressive symptoms in MS. Longitudinal studies show inconsistent results but provide some data indicating a relationship between increasing global cognitive decline and increasing depressive symptoms over time. Establishing whether such a relationship exists represents an important first step in understanding the temporal nature of that relationship along with any treatment implications. The current study investigated this relationship by using the adjusted difference between a demographic estimate of premorbid intellectual functioning (Barona) and a performance measure of current intellectual functioning (Shipley Institute of Living) to capture long-term global cognitive decline in MS patients. Degree of global cognitive decline was then related to a self-report measure of mood, evaluative, and vegetative depression symptoms (Chicago Multiscale Depression Inventory). Global cognitive decline accounted for 5% of the variance in mood-evaluative symptoms but none of the variance in vegetative symptoms. When groups experiencing moderate, mild, and no global cognitive decline were compared on depression symptom subscales, MS patients experiencing moderate cognitive decline reported significantly higher mood and evaluative, but not vegetative, depressive symptoms than MS patients with stable cognitive functioning. PMID:21246447

  10. Treatment of depression in an adolescent with cardiomyopathy and arrhythmia.

    Tanidir, Canan; Tanidir, Ibrahim C; Tuzcu, Volkan

    2015-10-01

    Patients with cardiomyopathy have a higher incidence of mood and anxiety disorders, resulting in greater probability for hospitalisation and increased risk for arrhythmia and death. We report a case of a 16-year-old boy with Danon disease, Wolff-Parkinson-White syndrome, and hypertrophic cardiomyopathy, who later developed depression and significant weight loss. The patient was successfully treated for his anxiety and depression with mirtazapine without any adverse cardiac effects. PMID:25400066

  11. Persistent depressive disorder

    American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders . 5th ed. Arlington, VA: American Psychiatric Publishing, 2013. Fava M, Cassano P. Mood disorders: major depressive disorder and dysthymic ...

  12. Glycogen Synthase Kinase-3 in the Etiology and Treatment of Mood Disorders

    Jope, Richard Scott

    2011-01-01

    The mood disorders major depressive disorder and bipolar disorder are prevalent, are inadequately treated, and little is known about their etiologies. A better understanding of the causes of mood disorders would benefit from improved animal models of mood disorders, which now rely on behavioral measurements. This review considers the limitations in relating measures of rodent behaviors to mood disorders, and the evidence from behavioral assessments indicating that glycogen synthase kinase-3 (...

  13. Glycogen synthase kinase-3 in the etiology and treatment of mood disorders

    Richard Scott Jope

    2011-01-01

    The mood disorders major depressive disorder and bipolar disorder are prevalent, are inadequately treated, and little is known about their etiologies. A better understanding of the causes of mood disorders would benefit from improved animal models of mood disorders, which now rely on behavioral measurements. This review considers the limitations in relating measures of rodent behaviors to mood disorders, and the evidence from behavioral assessments indicating that glycogen synthase kinase-3 (...

  14. The effects of nutrients on mood.

    Benton, D; Donohoe, R T

    1999-09-01

    A recent major theory was that a meal high in carbohydrate increased the rate that tryptophan enters the brain, leading to an increase in the level of the neurotransmitter serotonin that modulates mood. Although such a mechanism may be important under laboratory conditions it is unlikely to be of significance following the eating of any typical meal. As little as 2-4% of the calories of a meal as protein will prevent an increased availability of tryptophan. Arguably the food with the greatest impact on mood is chocolate. Those who crave chocolate tend to do so when they feel emotionally low. There have been a series of suggestions that chocolate's mood elevating properties reflect 'drug-like' constituents including anandamines, caffeine, phenylethylamine and magnesium. However, the levels of these substances are so low as to preclude such influences. As all palatable foods stimulate endorphin release in the brain this is the most likely mechanism to account for the elevation of mood. A deficiency of many vitamins is associated with psychological symptoms. In some elderly patients folate deficiency is associated with depression. In four double-blind studies an improvement in thiamine status was associated with improved mood. Iron deficiency anaemia is common, particularly in women, and is associated with apathy, depression and rapid fatigue when exercising. PMID:10610080

  15. SYMPTOMATOLOGY OF DEPRESSION IN DIFFERENT AGE GROUPS

    Vinodkumar M

    2014-05-01

    Full Text Available BACKGROUND: The “typical” depression presentation in primary care is dominated by physical (somatic complaints as opposed to psychological complaints. More than 50% of patients with depression report somatic complaints only and at least 60% of these somatic complaints are pain related. AIMS & OBJECTIVES: 1. To study the symptomatology of depression in different age groups. 2. To compare the symptomatology of depression found in each age groups. MATERALS & METHODS: Patients who have attended out-patient psychiatric department of tertiary general hospital in urban area and diagnosed as having depression were divided in four age groups (60years and were evaluated for depressive symptomatology. The SYMPTOMATOLOGY part was assessed by using two scales, (1 Inventory of depressive symptomatology scale (IDS-30 and (2 Hamilton depression rating scale (HDRS-17. RESULTS: There is high frequency of somatic symptoms (both general and gastrointestinal spontaneously as well as on systemic evaluation across all age groups amongst which most disturbing was headache followed by fatigue in all age groups. In all age groups who have reported primary depressive features like sadness and loss of pleasure, most of them had history of previous affective episodes so that they might have some insight into their depression. CONCLUSION: Our patients cannot voice their complaints spontaneously as there is a more of somatic symptoms presentation and striking rarity of spontaneously expressed depressed mood but it is invariably present on systemic interview across all age groups

  16. Trastorno del estado de ĂĄnimo mixto con sĂ­ntomas psicĂłticos asociado a Sibutramina Case Report: Mixed Mood Disorder with Psychotic Symptoms Associated to Sibutramine

    Juan Carlos Alba

    2006-03-01

    Full Text Available Objetivos: describir un caso de una persona que en relación con el uso de Sibutramina presenta trastorno del estado de ånimo. Métodos: reporte de caso. Resultados: paciente de 28 años, quien presenta primer episodio maniaco con síntomas psicóticos y posterior asociación de sintomatología depresiva inducida probablemente por el uso de Sibutramina. Conclusiones: la Sibutramina puede estar relacionada con la presentación de cuadros afectivos y psicóticos en personas vulnerables, por lo que se recomienda la evaluación del estado mental y los antecedentes de la persona a quien se va a prescribir.Objectives: Describe a case of Mood Disorder in relation to the use of Sibutramine. Methods: Case Report. Results: A 28 year-old patient who shows the first episode of mania with psychotic features, with later association of depressive symptoms possibly induced by the administration of Sibutramine. Conclusions: Sibutramine can be related with the development of affective and psychotic symptoms in a vulnerable patient. The evaluation of the mental state and history is recommended before its prescription.

  17. The genetics of mood disorders.

    Lau, Jennifer Y F; Eley, Thalia C

    2010-01-01

    Studying the genetics of mood disorders has never been more exciting. We have moved rapidly from establishing the genetic basis of depression to asking questions about how genes are expressed. This has been made possible by the capacity to collect and sequence DNA for large samples cheaply. But "multidisciplinary" approaches investigating interrelationships between risk factors have also been increasingly adopted, encouraging collaborations between those studying genes and those studying the brain, cognition, and/or the social environment. In this review, we first describe findings from quantitative and molecular studies investigating the genetic basis of depression. Second, we present overviews of three hot topics of genetic research: gene-environment interplay, which considers how genetic factors shape exposure and responses toward the social environment; endophenotypic research, which identifies neurophysiological and psychological mediators of genetic risk; and epigenetics, which explain how early environments can foster changes in gene expression, altering subsequent emotional development. PMID:20001729

  18. Local cerebral glucose metabolism (LCMRGlc) in mood disorders

    PET studies (LCMRGlc units of Ό moles/min/100g and errors in std. dev.) were performed in patients with unipolar depression (n=11), bipolar depression (n=8), hypomania (n=8) and bipolar mixed states (n=3) in drug free states as well as during spontaneous or drug induced changes in mood, and age/sex matched normals (n=9). The major findings were: bipolar depressed patients had lower (P<0.001) supratentorial CMRGlc (16.7 +- 3.7) than normals (23.6 +- 1.9), hypomanic bipolars (24.7 + 44.6) or unipolars (24.5 +- 3.0). Bipolar mixed (16.4 +- 4.8) were not different from bipolar depressed but were different from all other states (P<0.02). Bipolar depressed and mixed showed increased (30%) supratentorial CMRGlc (P<0.05) with elevated mood (euthymic or hypomanic). Three rapid cycling bipolar patients (2 studies depressed and 1 hypomanic) also showed consistent increases (35%) in supratentorial CMRGlc from depressed to elevated mood state. Unipolar depressed patients had a low LCMRGlc ratio of caudate to hemispheric (c/Hem) (1.18 +- 0.09) compared to bipolar depression (1.30 +- 0.13) or normals (1.32 +- 0.07). Four unipolar patients studied after drug induced recovery showed corresponding return of Cd/Hem ratio to normal. Results of these studies show; delineation of bipolar depressed from unpolar depressed and normals. Separation of mixed biopolar from unipolar and correspondence of the former with bipolar rather than unipolar depression (controversial characterization by other diagnostic criteria), separation of unipolar from normal and bipolar by reduced LCMRGlc of caudate, and direct correspondence of changes in mood state with changes in LCMRGlc independent of whether changes in mood were drug induced or spontaneous

  19. Local cerebral glucose metabolism (LCMRGlc) in mood disorders

    Phelps, M.E.; Baxter, L.R.; Mazziotta, J.C.; Schwartz, J.M.; Gerner, R.H.

    1985-05-01

    PET studies (LCMRGlc units of ..mu.. moles/min/100g and errors in std. dev.) were performed in patients with unipolar depression (n=11), bipolar depression (n=8), hypomania (n=8) and bipolar mixed states (n=3) in drug free states as well as during spontaneous or drug induced changes in mood, and age/sex matched normals (n=9). The major findings were: bipolar depressed patients had lower (P<0.001) supratentorial CMRGlc (16.7 +- 3.7) than normals (23.6 +- 1.9), hypomanic bipolars (24.7 + 44.6) or unipolars (24.5 +- 3.0). Bipolar mixed (16.4 +- 4.8) were not different from bipolar depressed but were different from all other states (P<0.02). Bipolar depressed and mixed showed increased (30%) supratentorial CMRGlc (P<0.05) with elevated mood (euthymic or hypomanic). Three rapid cycling bipolar patients (2 studies depressed and 1 hypomanic) also showed consistent increases (35%) in supratentorial CMRGlc from depressed to elevated mood state. Unipolar depressed patients had a low LCMRGlc ratio of caudate to hemispheric (c/Hem) (1.18 +- 0.09) compared to bipolar depression (1.30 +- 0.13) or normals (1.32 +- 0.07). Four unipolar patients studied after drug induced recovery showed corresponding return of Cd/Hem ratio to normal. Results of these studies show; delineation of bipolar depressed from unpolar depressed and normals. Separation of mixed biopolar from unipolar and correspondence of the former with bipolar rather than unipolar depression (controversial characterization by other diagnostic criteria), separation of unipolar from normal and bipolar by reduced LCMRGlc of caudate, and direct correspondence of changes in mood state with changes in LCMRGlc independent of whether changes in mood were drug induced or spontaneous.

  20. Sleep and Mood During A Winter in Antarctica

    Palinkas, Lawrence A.; Houseal, Matt; Miller, Christopher

    2000-01-01

    Seasonal variations in sleep characteristics and their association with changes in mood were examined in 91 American men and women also who spent the 1991 austral winter at three different research stations in Antarctica. Measures of total hours of sleep over a 24-hr period, duration of longest (i.e.,"nighttime") sleep event, number of sleep events, time of sleep onset, and quality of sleep remained unchanged over the course of the austral winter (March through October). However, exposure to total darkness based on station latitude was significantly associated with total hours of sleep, duration of are longest sleep event, time of sleep onset, and quality of sleep. Reported vigor the previous month was a significant independent predictor of changes in all five sleep measures; previous month's measures of all six POMS subscales were significant independent predictors of sleep quality. Sleep characteristics were significant independent predictors of vigor and confusion the following month; total sleep, longest sleep event, sleep onset and sleep quality were significant independent predictors of tension-anxiety and depression. Changes in mood during the austral winter are preceded by changes in sleep characteristics, but prolonged exposure to the photoperiodicity characteristic of the high latitudes appears to be associated with improved sleep. In turn, mood changes appear to affect certain sleep characteristics, especially sleep quality.

  1. Mood disorders in childhood and adolescence

    Thiago Botter Maio Rocha

    2013-01-01

    Full Text Available The identification and treatment of mood disorders in children and adolescents has grown over the last decades. Major depression is one of the most common and debilitating disorders worldwide, imposing a massive burden to the youth population. Bipolar disorder is being increasingly recognized as having its roots early in life, and its presentation during childhood and adolescence has been submitted to extensive research. This review aims to highlight clinical aspects of the current knowledge on mood disorders in the pediatric population, presenting updated information on epidemiology, diagnostic procedures, and management strategies. Limitations of available evidence and future directions of research in the field are also discussed.

  2. Predictors of Self-Reported Depression in Korean Children 9 to 12 Years of Age

    Shin, Yun Mi; Cho, Hyun; Lim, Ki Young; Cho, Sun Mi

    2008-01-01

    Purpose The aim of this study was to evaluate the relationships among various psychosocial factors, behavior problems, and depressive symptoms reported by parents, and to investigate self-reported depression in Korean children using a community sample. Materials and Methods The sample consisted of 1279 children between 9 and 12 years of age. The children were evaluated using the Korean version of the Child Behavior Checklist (K-CBCL) and the Child Depression Inventory (CDI). Results The avera...

  3. Changeability of mood

    BrandstÀtter, Hermann

    1994-01-01

    Time sampling of emotional experience, several times a day over a period of several weeks (BrandstÀtter. 1977; Csikszentmihalyi, Larsen & Prescott, 1977; Diener, 1984), provides data which can be analyzed from many different perspectives. This paper focusses on the changeability of mood as a personality characteristic. Everybody would agree that mood changes all the time and that people differ in the frequency of mood changes. This intuitive idea was supported by a number of studies (for e...

  4. Asthma and Mood Disorders

    Kewalramani, Anupama; Bollinger, Mary E.; Postolache, Teodor T.

    2008-01-01

    The high rate of comorbidity of asthma and mood disorders would imply the possibility of potential shared pathophysiologic factors. Proposed links between asthma and mood disorders include a vulnerability (trait) and state connection. Vulnerability for both asthma and mood disorders may involve genetic and early developmental factors. State-related connections may include obstructive factors, inflammatory factors, sleep impairment, psychological reactions to chronic medical illness, as well a...

  5. 'You're depressed'; 'no I'm not': GPs' and patients' different models of depression. UMDS MSc in General Practice Teaching Group.

    1999-01-01

    Questionnaires concerning models of depression were completed by 90 general practitioners (GPs) and 681 patients. GPs and patients held similar beliefs about the role of mood-related symptoms, psychological causes, and non-medical treatments. However, the GPs reported greater support for somatic symptoms, medical causes, and medical treatments. Therefore, GPs and patients report different models of depression, with GPs favouring a more medical perspective. In addition, the results illustrated...

  6. PSYCHOLOGICAL CORRELATES OF POSTPARTUM DEPRESSION

    Anida Fazlagić

    2011-12-01

    Full Text Available Manual of Mental Disorders (DSM-IV, postpartum depression may include any nonpsychotic depressive disorder during the first four weeks of postpartum, according to research criteria during the first year after birth. The exact cause of postpartum depression is not yet known, and most researchers believe that postpartum depression is a bio-psycho-social problem. So far, the biological aspect of the disease is explained by changing the levels of estrogen and progesterone during pregnancy, and by decrease of hormone levels after birth. Psychological correlates are often associated with low selfesteem, pessimism as a personality trait, bad strategies of coping with stress, mood swings and emotional reactions. The social aspect of the disease is associated with the existential conditions of pregnant woman, support of partners and education level. This paper will include issues like hereditary causes and possible psychological factors of postpartum depression prevention. Nowadays, it is estimated that on average 15% of women, regardless of the pregnancy outcome, are suffering from postpartum depression. However, this information includes only those women who were diagnosed with postpartum depression and who themselves reported about it. Almost every woman receives basic care during pregnancy to prevent complications in the physiological level. This paper has shown possible psychological factors of postpartum depression prevention, the impact of optimism, self-esteem and coping skills.

  7. Optimal management of perimenopausal depression

    Barbara L Parry

    2010-06-01

    Full Text Available Barbara L ParryDepartment of Psychiatry, University of California, San Diego, USAAbstract: Only recently has the perimenopause become recognized as a time when women are at risk for new onset and recurrence of major depression. Untreated depression at this time not only exacerbates the course of a depressive illness, but also puts women at increased risk for sleep disorders, cardiovascular disease, diabetes, and osteoporosis. Although antidepressant medication is the mainstay of treatment, adjunctive therapy, especially with estrogen replacement, may be indicated in refractory cases, and may speed the onset of antidepressant action. Many, but not all, studies, report that progesterone antagonizes the beneficial effects of estrogen. Although some antidepressants improve vasomotor symptoms, in general they are not as effective as estrogen alone for relieving these symptoms. Estrogen alone, however, does not generally result in remission of major depression in most (but not all studies, but may provide benefit to some women with less severe symptoms if administered in therapeutic ranges. The selective serotonin reuptake inhibitors (SSRIs in addition to estrogen are usually more beneficial in improving mood than SSRIs or estrogen treatment alone for major depression, whereas the selective norepinephrine and serotonin reuptake inhibitors do not require the addition of estrogen to exert their antidepressant effects in menopausal depression. In addition to attention to general health, hormonal status, and antidepressant treatment, the optimal management of perimenopausal depression also requires attention to the individual woman’s psychosocial and spiritual well being.Keywords: menopause, depression, management

  8. Diurnal variation of depressive symptoms

    Wirz-Justice, Anna

    2008-01-01

    Diurnal variation of depressive symptoms appears to be part of the core of depression. Yet longitudinal investigation of an individual's pattern regularity, relation to clinical state, and clinical improvement reveals little homogeneity. Morning lows, afternoon slump, evening worsening - all can occur during a single depressive episode. Mood variability, or the propensity to produce mood swings, appears to be the characteristic that most predicts capacity to respond to treatment. Laboratory s...

  9. Effectiveness of cognitive behavior therapy for severe mood disorders in an acute psychiatric naturalistic setting: a benchmarking study.

    Björgvinsson, Thröstur; Kertz, Sarah J; Bigda-Peyton, Joseph S; Rosmarin, David H; Aderka, Idan M; Neuhaus, Edmund C

    2014-01-01

    The current study examined the effectiveness of brief cognitive behavior therapy (CBT) for severe mood disorders in an acute naturalistic setting. The sample included 951 individuals with either major depressive disorder (n = 857) or bipolar disorder with depressed mood (n = 94). Participants completed a battery of self-report measures assessing depression, overall well-being, and a range of secondary outcomes both before and after treatment. We found significant reductions in depressive symptoms, worry, self-harm, emotional lability, and substance abuse, as well as significant improvements in well-being and interpersonal relationships, post-treatment. Comparable to outpatient studies, 30% of the sample evidenced recovery from depression. Comparison of findings to benchmark studies indicated that, although the current sample started treatment with severe depressive symptoms and were in treatment for average of only 10 days, the overall magnitude of symptom improvement was similar to that of randomized controlled trials. Limitations of the study include a lack of control group, a limitation of most naturalistic studies. These findings indicate that interventions developed in controlled research settings on the efficacy of CBT can be transported to naturalistic, "real world" settings, and that brief CBT delivered in a partial hospital program is effective for many patients with severe depressive symptoms. PMID:24679127

  10. KLEPTOMANIA PRESENTING WITH MAJOR DEPRESSIVE DISORDER : A CASE REPORT

    Sharma, R. C.

    1996-01-01

    A 35 year old, married, educated woman of well to do economic condition who was referred by court for psychiatric opinion was found to suffer from “Kleptomania” with “recurrent major depressive disorder.” The patient had been stealing and hoarding (at times giving away when caught) defective and useless objects for the past 3 years .mostly during periods of depression and had been arrested twice for stealing. Her kleplomanic symptoms improved moderately when her depression lifted with antidep...

  11. Mood Disorders in Systemic Lupus Erythematosus

    Hanly, John G; Su, Li; Urowitz, Murray B; Romero-Diaz, Juanita; Gordon, Caroline; Bae, Sang-Cheol; Bernatsky, Sasha; Clarke, Ann E; Wallace, Daniel J; Merrill, Joan T; Isenberg, David A; Rahman, Anisur; Ginzler, Ellen M; Petri, Michelle; Bruce, Ian N; Dooley, M A; Fortin, Paul; Gladman, Dafna D; Sanchez-Guerrero, Jorge; Steinsson, Kristjan; Ramsey-Goldman, Rosalind; Khamashta, Munther A; Aranow, Cynthia; AlarcĂłn, Graciela S; Fessler, Barri J; Manzi, Susan; Nived, Ola; Sturfelt, Gunnar K; Zoma, Asad A; van Vollenhoven, Ronald F; Ramos-Casals, Manuel; Ruiz-Irastorza, Guillermo; Lim, S Sam; Kalunian, Kenneth C; Inanc, Murat; Kamen, Diane L; Peschken, Christine A; Jacobsen, Soren; Askanase, Anca; Theriault, Chris; Thompson, Kara; Farewell, Vernon

    2015-01-01

    disorders (4 types, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) and 18 other neuropsychiatric events. Global disease activity scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage scores (Systemic Lupus International Collaborating Clinics/American College...... risk was associated with Asian race/ethnicity (P = 0.01) and treatment with immunosuppressive drugs (P = 0.003). Mood disorders were associated with lower mental health and mental component summary scores but not with the SLEDAI-2K, SDI, or lupus autoantibodies. Among the 232 patients with depression......OBJECTIVE: To examine the frequency, characteristics, and outcome of mood disorders, as well as clinical and autoantibody associations, in a multiethnic/racial, prospective inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: Patients were assessed annually for mood...

  12. Vegetarian diets are associated with healthy mood states: a cross-sectional study in Seventh Day Adventist adults

    Johnston Carol S

    2010-06-01

    Full Text Available Abstract Background The physical health status of vegetarians has been extensively reported, but there is limited research regarding the mental health status of vegetarians, particularly with regard to mood. Vegetarian diets exclude fish, the major dietary source of eicosapentaenoic acid (EPA and docosahexaenoic acid (DHA, critical regulators of brain cell structure and function. Omnivorous diets low in EPA and DHA are linked to impaired mood states in observational and experimental studies. Methods We examined associations between mood state and polyunsaturated fatty acid intake as a result of adherence to a vegetarian or omnivorous diet in a cross-sectional study of 138 healthy Seventh Day Adventist men and women residing in the Southwest. Participants completed a quantitative food frequency questionnaire, Depression Anxiety Stress Scale (DASS, and Profile of Mood States (POMS questionnaires. Results Vegetarians (VEG:n = 60 reported significantly less negative emotion than omnivores (OMN:n = 78 as measured by both mean total DASS and POMS scores (8.32 ± 0.88 vs 17.51 ± 1.88, p = .000 and 0.10 ± 1.99 vs 15.33 ± 3.10, p = .007, respectively. VEG reported significantly lower mean intakes of EPA (p p p p p p p p p p Conclusions The vegetarian diet profile does not appear to adversely affect mood despite low intake of long-chain omega-3 fatty acids.

  13. [Mood induction procedures: a critical review].

    Gilet, A-L

    2008-06-01

    For a long period in the history of psychological research, emotion and cognition have been studied independently, as if one were irrelevant to the other. The renewed interest of researchers for the study of the relations between cognition and emotion has led to the development of a range of laboratory methods for inducing temporary mood states. This paper aims to review the main mood induction procedures allowing the induction of a negative mood as well as a positive mood, developed since the pioneer study of Schachter and Singer [Psychol Rev 69 (1962) 379-399] and to account for the usefulness and problems related to the use of such techniques. The first part of this paper deals with the detailed presentation of some of the most popular mood induction procedures according to their type: simple (use of only one mood induction technique) or combined (association of two or more techniques at once). The earliest of the modern techniques is the Velten Mood Induction Procedure [Behav Res Ther 6 (1968) 473-482], which involves reading aloud sixty self-referent statements progressing from relative neutral mood to negative mood or dysphoria. Some researchers have varied the procedure slightly by changing the number of the statements [Behav Res Ther 21 (1983) 233-239, Br J Clin Psychol 21 (1982) 111-117, J Pers Soc Psychol 35 (1977) 625-636]. Various other mood induction procedures have been developed including music induction [Cogn Emotion 11 (1997) 403-432, Br J Med Psychol 55 (1982) 127-138], film clip induction [J Pers Soc Psychol 20 (1971) 37-43, Cogn Emotion 7 (1993) 171-193, Rottenberg J, Ray RR, Gross JJ. Emotion elicitation using films. In: Coan JA, Allen JJB, editors. The handbook of emotion elicitation and assessment. New York: Oxford University Press, 2007], autobiographical recall [J Clin Psychol 36 (1980) 215-226, Jallais C. Effets des humeurs positives et négatives sur les structures de connaissances de type script. ThÚse de doctorat non publiée. Université de Nantes, Nantes] or combined inductions [Gilet AL. Etude des effets des humeurs positives et négatives sur l'organisation des connaissances en mémoire sémantique. ThÚse de doctorat non publiée, Université de Nantes, Nantes, J Ment Imagery 19 (1995) 133-150]. In music or film clip inductions, subjects are asked to listen or view some mood-suggestive pieces of material determined by the experimenter according to standardized music or film sets [J Ment Imagery 19 (1995) 133-150, Cogn Emotion 7 (1993) 171-193] and selected to elicit target moods. According to many authors, these two mood induction procedures seem to be among the most effective manners to induce moods [Br J Psychol 85 (1994) 55-78, Eur J Soc Psychol 26 (1996) 557-580] in an individual or in a group setting [Jallais C. Effets des humeurs positives et négatives sur les structures de connaissances de type script. ThÚse de doctorat non publiée. Université de Nantes, Nantes]. As it is believed that multiple inductions contribute additively to a mood [Am Psychol 36 (1981) 129-148], researchers proposed to combine two or more techniques at the same time. Thus, the Velten Mood Induction Procedure has been successively associated with the hypnosis mood induction procedure [J Pers Soc Psychol 42 (1982) 927-934], the music mood induction procedure [Behav Res Ther 21 (1983) 233-239, J Exp Soc Psychol 26 (1990) 465-480] or the imagination mood induction procedure [Br J Clin Psychol 21 (1982) 111-117]. Successful combinations of inductions usually use a first induction that occupies foreground attention and a second one that contributes to congruent background atmosphere. One of the most successful combined mood induction procedures has been developed by Mayer, Allen and Beauregard [J Ment Imagery 19 (1995) 133-150]. This technique associates guided imagery with music and is supposed to increase effectiveness of the induction. In the second part of this paper the aim is to present the usefulness of mood induction procedures in the study of cognitive processes in depression [Clin Psychol Rev 25 (2005) 487-510], borderline personality disorder [J Behav Ther Exp Psychiatry 36 (2005) 226-239] or associated with brain imaging [Am J Psychiatry 161 (2004) 2245-2256]. Then the inherent problems to the use of experimental mood induction procedures are reconsidered. Doubts have effectively arisen about the effectiveness and validity of the mood induction procedures usually used in research. Some authors questioned whether a sufficient intensity of mood is produced or the possibility that the effects observed are due mainly to demand effects [Br J Psychol 85 (1994) 55-78, Clin Psychol Rev 10 (1990) 669-697, Eur J Soc Psychol 26 (1996) 557-580]. In fact, the various mood induction procedures are not equal with regard to the demand effects observed. The question of demand characteristics with respect to mood induction procedures is still under debate, even if demand effects are supposed to be most likely to occur with self-statement techniques (especially with the Velten mood induction procedure) or when subjects are explicitly instructed to try to enter a specific mood state [Eur J Soc Psychol 26 (1996) 557-580]. Another interrogation relates to the effectiveness of these various procedures of induction and the duration of induced moods. Generally, the various techniques used produce true changes of moods in the majority if not the whole of the subjects. However, certain procedures seem more effective in inducing a mood in particular [Br J Psychol 85 (1994) 55-78, Clin Psychol Rev 10 (1990) 669-697, Eur J Soc Psychol 26 (1996) 557-580]. As for the duration of induced moods this depends at the same time on the procedure used and the mood induced. Nevertheless, mood induction remains fundamental in the study of the effects of mood on the cognitive activities, insofar as it makes it possible to study the effects of negative as well as positive moods. PMID:18558143

  14. Vascular Depression

    Yunus Emre Sönmez

    2013-03-01

    Full Text Available Research until today has found a positive relationship between vascular risk factors and depression. With the advance in neuroimaging methods in the last years, a more definite relation between cerebrovascular diseases and old-age depression have been described, and in the light of the studies in this field, a ‘vascular depression’ subtype has been defined. According to this hypothesis, ‘vascular depression’ implies a special depression subtype which begins first time in old age, which is accompanied less by depressive mood, characterized by impairment in cognitive abilities, especially in executive functions, dominated by psychomotor retardation and somatic symptoms, and lack of family history of depression. A group of researchers stated that defining vascular depression only with clinical findings would be insufficient, suggested brain imaging findings are required for the diagnosis, and subcortical hyperintensities are related to depression symptoms. Late-onset depression is shown to be related to frontal subcortical white-matter hyperintensities, and these findings were found to be correlated with affect dysregulation and executive dysfunction in late-life depression. Executive dysfunction as well as memory and attention problems in late-onset depression have been shown in different studies. Thus, vascular depression hypothesis is thought to be related with subcortical dementia upon these findings. There is currently no consensus on the concept of vascular depression and diagnostic criteria. But this concept which is explaining a subgroup of late-life depressions, predicting the treatment outcome, and implying a preventable disease with the control of vascular factors, makes vascular depression a very important topic. In this review, research on vascular depression hypothesis, findings and critics about the concept will be reviewed.(Arc­hi­ves of Neu­ropsy­chi­atry 2013; 50: 1-8

  15. Improvement of Depression after Treatment of Dural Arteriovenous Fistula: A Case Report and a Review

    Minoru Nakagawa; Kenji Sugiu; Koji Tokunaga; Chihoko Sakamoto; Kenjiro Fujiwara

    2012-01-01

    Patients with dural arteriovenous fistulas (DAVFs) in the transverse-sigmoid sinus suffer from several symptoms: bruit, headache, visual impairment, and so on. But depression is rare in patients with DAVF. The authors reported a rare case presenting the improvement of depression after the treatment of a dural arteriovenous fistula in the left transverse-sigmoid sinus. A 46-year-old male had suffered from depression and was treated with antidepressants at a local hospital for four years. The p...

  16. Development of a Patient-Report Measure of Psychotherapy for Depression

    Miranda, Jeanne; Hepner, Kimberly A; Azocar, Francisca; Greenwood, Greg; Ngo, Victoria; Burnam, M. Audrey

    2010-01-01

    Despite clear indications of need to improve depression treatment, practical tools that efficiently measure psychotherapy are not available. We developed a patient-report measure of psychotherapy for depression that assesses Cognitive Behavioral (CBT), Interpersonal (IPT), and Psychodynamic therapies. 420 patients with depression from a large managed behavioral health care organization completed the measure. The three subscales measuring CBT, IPT, and Psychodynamic Therapy showed good interna...

  17. Development of a Patient-Report Measure of Psychotherapy for Depression

    Miranda, Jeanne; Hepner, Kimberly A; Azocar, Francisca; Greenwood, Greg; Ngo, Victoria; Burnam, M. Audrey

    2009-01-01

    Despite clear indications of need to improve depression treatment, practical tools that efficiently measure psychotherapy are not available. We developed a patient-report measure of psychotherapy for depression that assesses Cognitive Behavioral (CBT), Interpersonal (IPT), and Psychodynamic therapies. 420 patients with depression from a large managed behavioral health care organization completed the measure. The three subscales measuring CBT, IPT, and Psychodynamic Therapy showed good interna...

  18. The relationship between self-report of depression and media usage

    Martin Block; Stern, Daniel B.; Sang Lee; Bobby Calder; Rudick, Charles N.; Blood, Anne J.

    2014-01-01

    Depression is a debilitating condition that adversely affects many aspects of a person's life and general health. Earlier work has supported the idea that there may be a relationship between the use of certain media and depression. In this study, we tested if self-report of depression (SRD), which is not a clinically based diagnosis, was associated with increased internet, television, and social media usage by using data collected in the Media Behavior and Influence Study (MBIS) database (N=1...

  19. Can Reporting Heterogeneity Explain Differences in Depressive Symptoms across Europe?

    Kok, Renske; Avendano, Mauricio; d'Uva, Teresa Bago; Mackenbach, Johan

    2012-01-01

    Depression is one of the leading causes of disability in the developed world. Previous studies have shown varying depression prevalence rates between European countries, and also within countries, between socioeconomic groups. However, it is unclear whether these differences reflect true variations in prevalence or whether they are attributable to


  20. Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study

    Aimee C. Richardson

    2015-07-01

    Full Text Available Studies investigating possible associations between iron status and mood or depressive symptoms have reported inconsistent results. However, they have neither used body iron to measure iron status nor measured mood using daily measures. We investigated whether body iron was associated with depressive symptoms, daily mood, daily tiredness, difficulty concentrating, and stress in young adult women and men. Young adult (17–25 years women (n = 562 and men (n = 323 completed the Center for Epidemiologic Studies Depression Scale, then reported negative and positive mood, and other states daily for 13 days. Non-fasting venous blood was collected to determine hemoglobin, serum ferritin and soluble transferrin receptor (to calculate body iron, C-reactive protein, and alpha-1-acid glycoprotein concentration. Regression models tested linear associations between body iron and the outcome variables, controlling for possible confounders. No associations were found between body iron and the outcome variables in women. However, higher body iron was associated with more depressive symptoms in men (3.4% more per body iron mg/kg; 95% confidence intervals (CI: 0.8%, 5.9%. In young adult women, body iron is unlikely to be associated with significant deficits in mood or depressive symptoms. However, higher body iron may be associated with more depressive symptoms in young adult men.

  1. Asthma, allergy, mood disorders, and nutrition

    Wilczynska-Kwiatek A

    2009-12-01

    Full Text Available Abstract Background Growing evidence supports comorbidity of asthma and allergies with mood disorders and various connections between these diseases. It still remains unclear whether this comorbidity is caused by the same pathophysiological factors or whether there are other links between asthma and depression. There is no definite answer to the question of an optimal treatment to deal with both asthma and depression, when they occur simultaneously. Epidemiological and clinical trials on the influence of nutrition on certain diseases suggest the effects of ?3 polyunsaturated fatty acids (PUFAs in aiding treatment of mood disorders and inflammatory conditions. Objective This is an overview showing the connections between asthma, allergic disease, and mood disorders, and the influence of nutrition on these conditions. Evidence indicates positive correlations between consumption of PUFAs and mood correction. Several analyses show the connection between diet and asthma. They may form a basis for potential recommending ?3 PUFAs as an adjuvant in prevention and treatment of mental disorders, asthma, and allergy.

  2. Disruption of the circadian timing systems: molecular mechanisms in mood disorders.

    Mendlewicz, Julien

    2009-01-01

    Depression is one of the leading causes of morbidity worldwide and represents a huge burden to society. As with many other psychiatric disorders, a genetic basis for depression has been identified. Evidence for the role of circadian genes in depression is particularly compelling. Circadian gene mutations are also associated with circadian rhythm disorders such as familial advanced sleep phase syndrome, delayed sleep phase syndrome, and non-24-hour sleep-wake syndrome. Such disorders, plus the other manifestations of a disrupted circadian system such as hormone dysregulation, are often observed among those with depression. This suggests a shared aetiology between circadian disruption and depression, although the exact mechanisms underlying the association are unclear. This paper reviews the molecular mechanisms involved in depression, with an emphasis on circadian genes. Twin studies in depression have reported probandwise concordance rates of 40% and 70% using narrow and broad diagnostic criteria, respectively, and heritability of over 85% for bipolar disorder. In association studies, increased susceptibility to depression has been noted in those with polymorphisms in the following: D-amino-acid-oxidase activator/G30 gene complex, glucocorticoid receptor gene, serotonin transporter gene, tryptophan hydroxylase 2 gene, dopamine transporter gene and G protein-coupled receptor 50 gene. Polymorphisms in these genes have also been linked to a better or worse response to antidepressant therapy, an increased likelihood of responding poorly to adversity and increased suicide ideation. Polymorphisms in the CLOCK, BMAL1, Per3 and TIMELESS genes have been associated with susceptibility to mood disorder, and single nucleotide polymorphisms and haplotypes in several circadian genes have been observed among those displaying certain circadian phenotypes, including worse mood in the evening, insomnia in mania and early, middle or late insomnia in depression. Manipulation of the circadian timing system via sleep deprivation, bright light or pharmacological therapy has also been shown to alleviate depressive symptoms, providing further evidence for the role of circadian dysfunction in depression pathophysiology. The new antidepressant agomelatine is the first melatonergic antidepressant with an innovative mode of action: it is a melatonergic MT(1), MT(2) receptor agonist and 5-HT(2c) antagonist, and is able to restore the internal clock, which is profoundly disturbed in depression, thus being efficacious in major depressive disorders. In conclusion, a wealth of evidence is now available supporting a genetic basis for depression. The apparent importance of mutations in the circadian genes in determining disease susceptibility, disease recurrence and response to treatment suggests that the circadian pathway represents an attractive target for pharmacological manipulation to improve management of this debilitating disorder. PMID:19708722

  3. Controversies about a common etiology for eating and mood disorders

    Rossetti, Clara; Halfon, Olivier; Boutrel, Benjamin

    2014-01-01

    Obesity and depression represent a growing health concern worldwide. For many years, basic science and medicine have considered obesity as a metabolic illness, while depression was classified a psychiatric disorder. Despite accumulating evidence suggesting that obesity and depression may share commonalities, the causal link between eating and mood disorders remains to be fully understood. This etiology is highly complex, consisting of multiple environmental and genetic risk factors that inter...

  4. Improving mood with psychoanalytic and cognitive therapies (IMPACT): a pragmatic effectiveness superiority trial to investigate whether specialised psychological treatment reduces the risk for relapse in adolescents with moderate to severe unipolar depression: study protocol for a randomised controlled trial

    Suckling John; Senior Robert; Roberts Christopher; Reynolds Shirley; Kelvin Raphael; Hill Jonathan; Dubicka Bernadka; Byford Sarah; Tsancheva Sonya; Goodyer Ian M; Wilkinson Paul; Target Mary; Fonagy Peter

    2011-01-01

    Abstract Background Up to 70% of adolescents with moderate to severe unipolar major depression respond to psychological treatment plus Fluoxetine (20-50 mg) with symptom reduction and improved social function reported by 24 weeks after beginning treatment. Around 20% of non responders appear treatment resistant and 30% of responders relapse within 2 years. The specific efficacy of different psychological therapies and the moderators and mediators that influence risk for relapse are unclear. T...

  5. Depressive symptomatology in hospitalised children

    M. Rangaka

    1993-05-01

    Full Text Available This study was undertaken to determine the extent and nature of depressive symptoms exhibited by black South African children during hospitalisation for orthopaedic procedures. Social factors associated with the risk for depression, in response to hospitalisation, were also examined. Pre- and post-test assessments were conducted on a sample of 30 children aged between 6 and 12 years. The assessment entailed a structured interview, together with the following psychometric instruments: A Global Mood Scale, a Depressive Symptoms Checklist, a Hospital Fears Rating Scale and a Self Report Depression Rating Scale. A large proportion of the children were rated by ward sisters as showing high levels of depressive symptomatology two weeks after admission to hospital. As expected, discrepancies were found between adult and child self-ratings of depression. The results of this study indicate that hospitalisation for orthopaedic child patients is associated with the development of depressive symptomatology. It is suggested that emphasis be placed on the development of supportive programmes and procedures aimed at maximising children's coping responses to hospitalisation, particularly for children who find themselves Isolated from their communities and families, as a result of both centralised health services and poor socio-economic conditions.

  6. Brief report: Explaining differences in depressive symptoms between African American and European American adolescents.

    Mrug, Sylvie; King, Vinetra; Windle, Michael

    2016-01-01

    African American adolescents report more depressive symptoms than their European American peers, but the reasons for these differences are poorly understood. This study examines whether risk factors in individual, family, school, and community domains explain these differences. African American and European American adolescents participating in the Birmingham Youth Violence Study (N = 594; mean age 13.2 years) reported on their depressive symptoms, pubertal development, aggressive and delinquent behavior, connectedness to school, witnessing violence, and poor parenting. Primary caregivers provided information on family income and their education level, marital status, and depression, and the adolescents' academic performance. African American adolescents reported more depressive symptoms than European American participants. Family socioeconomic factors reduced this difference by 29%; all risk factors reduced it by 88%. Adolescents' exposure to violence, antisocial behavior, and low school connectedness, as well as lower parental education and parenting quality, emerged as significant mediators of the group differences in depressive symptoms. PMID:26580552

  7. ESTROGEN IN THE TREATMENT OF DEPRESSION: A CASE REPORT

    Putu Andrika Kusuma

    2014-02-01

    Full Text Available Depression led to the decline quality of life. With more incidence in women due tohormonal cycle caused women more susceptible to depression. Hormone that fluctuatesand holds a key role in brain and nerve cells is estrogen. Estrogen in premenopausalwomen already decreases. Treatment of depression in premenopausal women who gopast the various considerations needs to consider the provision of hormonal therapy. Inthe case of patients treated with psychotherapy and pharmacotherapy in the form of 2 x20 mg Fluoxetine by mouth and hormonal therapy in the form of 1 x 2 mg Estradiol.Feasibility study to evaluate the hormonal therapy contraindications such as breastcancer also needs to be done.

  8. Self-Reported Depressive Symptoms in Lesbian Birth Mothers and Comothers

    Maccio, Elaine M.; Pangburn, Jaimee A.

    2012-01-01

    Despite the frequency of postpartum depression, little is known about the experiences of lesbian birth mothers and their female partners, or comothers. In this modest yet important exploratory investigation, 20 lesbian mothers completed a survey of self-reported postpartum depressive symptoms (PDS) and related risk factors. Results indicate that…

  9. Differential Effects of Hormone Therapy on Serotonin, Vascular Function and Mood in the KEEPS

    Raz, Limor; Hunter, Larry; Dowling, N. Maritza; Wharton, Whitney; Gleason, Carey; Jayachandran, Muthuvel; Anderson, Layne; Asthana, Sanjay; Miller, Virginia

    2016-01-01

    Background Serotonin (5-hydroxytryptamine, 5-HT) is modulated by sex steroid hormones and affects vascular function and mood. In the Kronos Early Estrogen Prevention Cognitive and Affective Ancillary Study (KEEPS-Cog), women randomized to oral conjugated equine estrogens (oCEE) showed greater benefit on affective mood states than women randomized to transdermal 17ÎČ-estradiol (tE2) or placebo (PL). This study examined the effect of these treatments on the platelet content of 5-HT as a surrogate measure of 5-HT synthesis and uptake in the brain. Methods The following were measured in a subset (n = 79) of women enrolled in KEEPS-Cog: 5-HT by ELISA, carotid intima-medial thickness (CIMT) by ultrasound, endothelial function by reactive hyperemia index (RHI), and self-reported symptoms of affective mood states by the Profile of Mood States (POMS) questionnaire. Results Mean platelet content of 5-HT increased by 107.0%, 84.5% and 39.8%, in tE2, oCEE and PL groups, respectively. Platelet 5-HT positively correlated with estrone in the oCEE group and with 17ÎČ- estradiol in the tE2 group. Platelet 5-HT showed a positive association with RHI, but not CIMT, in the PL and oCEE groups. Reduction in mood scores for depression-dejection and anger-hostility associated with elevations in platelet 5-HT only in the oCEE group (r = −0.5, p = 0.02). Conclusions Effects of oCEE compared to tE2 on RHI and mood may be related to mechanisms involving platelet, and perhaps neuronal, uptake and release of 5-HT and reflect conversion of estrone to bioavailable 17ÎČ- estradiol in platelets and the brain. PMID:26652904

  10. Paroxetine in the treatment of recurrent brief depressive disorder

    Sathya Prakash

    2013-01-01

    Full Text Available Recurrent brief depressive disorder is now a well-recognized type of depressive disorder. However, there is still no clear evidence base for its treatment. The efficacy of several drugs including antidepressants and mood stabilizers in this disorder has been controversial. Methodological limitations need to be considered when interpreting the results of studies on efficacy of drugs in this disorder. We report a case of recurrent brief depressive disorder that responded dramatically to paroxetine. However, there is a need for larger, methodologically sound, double-blind, placebo-controlled studies.

  11. Discriminating Between Bipolar Disorder and Major Depressive Disorder.

    Vöhringer, Paul A; Perlis, Roy H

    2016-03-01

    Rates of misdiagnosis between major depressive disorder and bipolar disorder have been reported to be substantial, and the consequence of such misdiagnosis is likely to be a delay in achieving effective control of symptoms, in some cases spanning many years. Particularly in the midst of a depressive episode, or early in the illness course, it may be challenging to distinguish the 2 mood disorders purely on the basis of cross-sectional features. To date, no useful biological markers have been reliably shown to distinguish between bipolar disorder and major depressive disorder. PMID:26876315

  12. The effect of mood congruence music in mood change.

    Langenberg, L.E.

    2013-01-01

    This study was set out to assess the importance of listening to mood congruent songs versus mood incongruent songs in terms of mood change. Forty-eight participants were divided into four groups (1) participants with a happy pretest score and who received a happy song (mood congruent), (2) participants with a sad pretest mood and who received a happy song (mood incongruent) (3) participants with a happy pretest score who received a sad song and (mood incongruent)(4) participants with a sad pr...

  13. Severe depression associated with ACTH, PRL, and GH deficiency: a case report.

    Kawai, K; Tamai, H; Nishikata, H; Kobayashi, N; Matsubayashi, S

    1994-06-01

    A 68-year-old man was hospitalized in August, 1990 with general malaise, loss of energy, poor appetite and severe depression. He had experienced depressed moods, markedly diminished interest, feelings of worthlessness, diminished ability to think, general malaise and muscle weakness beginning in November, 1989. He was treated for depression at another hospital until his emergent admission to our hospital because of difficulty in walking. Laboratory studies disclosed hyponatremia, low plasma ACTH level (4.2 pmol/L), and a low cortisol level (27.6 nmol/L). Rapid ACTH test elicited an increase in serum cortisol from 75.6 nmol/L to 361.2 nmol/L at 30 min. Ovine corticotropin releasing hormone (CRH) did not stimulate secretion of either ACTH or cortisol. Human growth hormone releasing hormone (GRH) together with thyrotropin releasing hormone (TRH) elicited a normal response of TSH and low responses of GH and PRL. The patient's serum autoantibodies to anterior pituitary cell membranes using GH3 rat pituitary cells and AtT-20 mouse pituitary cells were positive. On the basis of these data, the diagnosis of selective ACTH, GH and PRL deficiency was made and thought to have been caused by lymphocytic adenohypophysitis. Following cortisol replacement therapy, he quickly regained his appetite and was restored to a normal mental state of being. PMID:7951579

  14. Intramuscular ketamine in acute depression: A report on two cases

    Harihar, Chilukuri; Dasari, Padmavathy; Srinivas, Jakka Sriramulu

    2013-01-01

    It takes about 2 weeks for the onset of antidepressant action of drugs while electroconvulsive therapy though faster, is a cumbersome procedure requiring an anaesthetist and at least a minor operation theatre. Recent studies have shown that Ketamine, when given to severely depressed patients in the dose of 0.5 mg/kg as a slow intravenous infusion over 40 minutes, brought about acute relief from depression and amelioration of suicidal risk within a few hours. The improvement, however, was tran...

  15. Mood Adjustment via Mass Communication.

    Knobloch, Silvia

    2003-01-01

    Proposes and experimentally tests mood adjustment approach, complementing mood management theory. Discusses how results regarding self-exposure across time show that patterns of popular music listening among a group of undergraduate students differ with initial mood and anticipation, lending support to mood adjustment hypotheses. Describes how


  16. Music feels like moods feel

    KrisGoffin

    2014-04-01

    Full Text Available While it is widely accepted that music evokes moods, there is disagreement over whether music-induced moods are relevant to the aesthetic appreciation of music as such. The arguments against the aesthetic relevance of music-induced moods are: (1 moods cannot be intentionally directed at the music and (2 music-induced moods are highly subjective experiences and are therefore a kind of mind-wandering. This paper presents a novel account of musical moods that avoids these objections. It is correct to say that a listener's entire mood is not relevant to the aesthetic appreciation of music. However, the experience of mood consists of having different feelings. Music induces feelings that are intentionally directed at the music and clusters of these feelings can be recognized as typical of a specific mood. Therefore, mood-feelings are relevant to the aesthetic appreciation of music.

  17. Music feels like moods feel

    Goffin, Kris

    2014-01-01

    While it is widely accepted that music evokes moods, there is disagreement over whether music-induced moods are relevant to the aesthetic appreciation of music as such. The arguments against the aesthetic relevance of music-induced moods are: (1) moods cannot be intentionally directed at the music and (2) music-induced moods are highly subjective experiences and are therefore a kind of mind-wandering. This paper presents a novel account of musical moods that avoids these objections. It is correct to say that a listener’s entire mood is not relevant to the aesthetic appreciation of music. However, the experience of mood consists of having different feelings. Music induces feelings that are intentionally directed at the music and clusters of these feelings can be recognized as typical of a specific mood. Therefore, mood-feelings are relevant to the aesthetic appreciation of music. PMID:24795677

  18. Management of bipolar depression

    Jae Seung Chang

    2011-01-01

    Full Text Available Patients with bipolar disorder spend more time in a depressed than manic state, even with individualized treatment. To date, bipolar depression is often misdiagnosed and ineffectively managed both for acute episodes and residual symptoms. This review attempts to summarize the current status of available treatment strategies in the treatment of bipolar depression. For acute and prophylactic treatment, a substantial body of evidence supports the antidepressive efficacy of lithium for bipolar disorders and its antisuicidal effects. Among numerous anticonvulsants with mood-stabilizing properties, valproate and lamotrigine could be first-line options for bipolar depression. Due to receptor profile, mood-stabilizing properties of second-generation antipsychotics have been explored, and up to date, quetiapine and olanzapine appear to be a reasonable option for bipolar depression. The usefulness of antidepressants in bipolar depression is still controversial. Current guidelines generally recommend the cautious antidepressant use in combination with mood stabilizers to reduce the risk of mood elevation or cycle acceleration. Results from clinical trials on psychosocial intervention are promising, especially when integrated with pharmacotherapy. Most patients with bipolar depression need individualized and combined treatment, although the published evidence on this type of treatment strategy is limited. Future studies on the utility of currently available agents and modalities including psychosocial intervention are required.

  19. The increasing burden of depression

    LĂ©pine J-P

    2011-05-01

    Full Text Available Jean-Pierre Lépine1, Mike Briley21HÎpital LariboisiÚre Fernand Widal, Assistance Publique HÎpitaux de Paris Unité INSERM 705 CNRS UMR 8206, Université Paris Diderot, Paris, France; 2NeuroBiz Consulting and Communication, Castres, FranceAbstract: Recent epidemiological surveys conducted in general populations have found that the lifetime prevalence of depression is in the range of 10% to 15%. Mood disorders, as defined by the World Mental Health and the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, have a 12-month prevalence which varies from 3% in Japan to over 9% in the US. A recent American survey found the prevalence of current depression to be 9% and the rate of current major depression to be 3.4%. All studies of depressive disorders have stressed the importance of the mortality and morbidity associated with depression. The mortality risk for suicide in depressed patients is more than 20-fold greater than in the general population. Recent studies have also shown the importance of depression as a risk factor for cardiovascular death. The risk of cardiac mortality after an initial myocardial infarction is greater in patients with depression and related to the severity of the depressive episode. Greater severity of depressive symptoms has been found to be associated with significantly higher risk of all-cause mortality including cardiovascular death and stroke. In addition to mortality, functional impairment and disability associated with depression have been consistently reported. Depression increases the risk of decreased workplace productivity and absenteeism resulting in lowered income or unemployment. Absenteeism and presenteeism (being physically present at work but functioning suboptimally have been estimated to result in a loss of $36.6 billion per year in the US. Worldwide projections by the World Health Organization for the year 2030 identify unipolar major depression as the leading cause of disease burden. This article is a brief overview of how depression affects the quality of life of the subject and is also a huge burden for both the family of the depressed patient and for society at large.Keywords: epidemiology, DALY, mortality risk, economic burden, family burden, depression

  20. Uncontrolled Self-Medication with Venlafaxine in a Patient with Major Depressive Disorder

    Song, Ji-Hye; Yu, Bum-Hee; Lee, Dongsoo; Yoon, Se Chang; Jeon, Hong Jin

    2010-01-01

    Antidepressants are known to have no significant ability to cause addiction. However, a recent study showed many individuals with mood disorders self-medicated with antidepressants to relieve symptoms. We report here a male physician, diagnosed five years ago with major depressive disorder, with insomnia, anxiousness, and chest heaviness. He began self-medicating with 150 mg of venlafaxine daily, without any monitoring. During his most recent severe depressive episode, he was taking up to 1,5...

  1. Ketamine-induced affective switch in a patient with treatment-resistant depression

    Girish Banwari; Prutha Desai; Prahlad Patidar

    2015-01-01

    There is growing evidence to support the rapid, albeit short-lived antidepressant effect of subanesthetic dose of ketamine, a noncompetitive glutamate N-methyl-D-aspartate receptor antagonist in treatment-resistant unipolar and bipolar depression. Ketamine is known to cause transient mood elevation or euphoria, psychotomimetic effects, and dissociative symptoms, but its use in unipolar or bipolar depression has not been reported to induce an affective switch amounting to persistent or prolong...

  2. Early trauma and mood disorders in youngsters

    Caroline Elizabeth Konradt

    2013-01-01

    Full Text Available OBJECTIVE: To verify early experiences of childhood abuse and neglect among young with bipolar disorder (BD, major depression (MDD, and controls. METHOD: Case-control study nested to a population-based cross-sectional study. The diagnosis was performed via the structured clinical interview for DSM-IV Axis I Disorders (SCID. Traumatic events were analyzed using the Portuguese version - QuestionĂĄrio sobre Traumas na InfĂąncia (CTQ - based on the Childhood Trauma Questionnaire. RESULTS: The sample comprised 231 adolescents with 95 individuals in the control group, 82 with MDD and 54 with BD (32 of type I and 22 type II. The prevalence of trauma or violence in childhood was 42.2%; among those, 54.7% had BD, 62.2% had MDD and 18.1% were in the control group. Young people with BD or MDD obtained higher means in total CTQ and among their components when compared with those in the control group. DISCUSSION: Reports on early traumatic experiences were more frequent among young people with mood disorders than in the general population, corroborating the literature on the subject. In this sense, the traumatic experiences during childhood seemed to contribute to the onset of the disorder.

  3. Depression as the cause and consequence of cerebrovascular diseases

    Rabi-Ćœikić Tamara

    2007-01-01

    Full Text Available Inbtroduction: Recent epidemiological, clinical, neuroimaging and neuropathological studies have reported substantial evidence on the complex interactive relationships between depression and cerebrovascular diseases, especially in older populations, and plausible explanations of the etiopathogenetic mechanisms in both directions have been proposed. Poststroke depression Although there is no general consensus regarding its prevalence, it is widely accepted that major depression after stroke is common and that it should be recognized as a key factor in rehabilitation and outcome following stroke. Vascular depression The "vascular depression" hypothesis presupposes that late-onset depression may often result from vascular damage to frontal-subcortical circuits implicated in mood regulation. This concept has stimulated many researches and the obtained results support the proposed hypothesis. Depression as a stroke risk factor Recent large studies have emphasized the role of depression per se in the development of subsequent stroke. Mechanisms proposed to explain the increased risk of cerebrovascular diseases in depressed patients There are a number of plausible mechanisms that could explain why depression may increase the risk of subsequent cerebrovascular disease, the most important being sympathoadrenal hyperactivity, platelet activation, an increase in inflammatory cytokines and an increased risk of arrhythmias. Conclusion: Thorough clinical examinations determining the conventional stroke risk factors in the population with depression, as well as management of depression as part of the overall measures for the reduction of cerebrovascular risk factors are of utmost importance.

  4. Ethiopathogenesis of Depressive Disorders

    Pasquini, M.; Berardelli, I; M. Biondi

    2014-01-01

    Etiology of depressive disorders is still unknown. Several factors are involved in its pathophysiology such as neurotransmitters and neuroendocrine alterations, genetics, life events and their appraisal. Some of these components are strictly linked. Subjects with a family member affected by mood disorders are more prone to suffer from depressive disorders. It is also true that receiving feedbacks of indifference or neglect during childhood from one parent who suffer from depression may repres...

  5. Circadian Gene Circuitry Predicts Hyperactive Behavior in a Mood Disorder Mouse Model.

    Hagihara, Hideo; Horikawa, Tomoyasu; Nakamura, Hironori K; Umemori, Juzoh; Shoji, Hirotaka; Kamitani, Yukiyasu; Miyakawa, Tsuyoshi

    2016-03-29

    Bipolar disorder, also known as manic-depressive illness, causes swings in mood and activity levels at irregular intervals. Such changes are difficult to predict, and their molecular basis remains unknown. Here, we use infradian (longer than a day) cyclic activity levels in αCaMKII (Camk2a) mutant mice as a proxy for such mood-associated changes. We report that gene-expression patterns in the hippocampal dentate gyrus could retrospectively predict whether the mice were in a state of high or low locomotor activity (LA). Expression of a subset of circadian genes, as well as levels of cAMP and pCREB, possible upstream regulators of circadian genes, were correlated with LA states, suggesting that the intrinsic molecular circuitry changes concomitant with infradian oscillatory LA. Taken together, these findings shed light onto the molecular basis of how irregular biological rhythms and behavior are controlled by the brain. PMID:27028761

  6. Translation and validation of Brunel Mood Scale for Serbian athlete population

    Rajkovic, Ivica

    2014-01-01

    Ivica Rajkovic, 2014. Translation and validation of Brunel Mood Scale for Serbian athlete population. Master Thesis in Sport and Exercise Psychology. Department of Sport Sciences, University of JyvÀskylÀ. 40p. Present study developed and validated the Serbian version (SERMS) of Brunel Mood Scale (BRUMS). BRUMS is 24 item questionnaire used to asses mood profile on six subscales (anger, confusion, depression, fatigue, tension and vigour). BRUMS was translated in to the Serbian using transl...

  7. How might circadian rhythms control mood? Let me count the ways
..

    McClung, Colleen A.

    2013-01-01

    Mood disorders are serious diseases that affect a large portion of the population. There have been many hypotheses put forth over the years to explain the development of major depression (MDD), bipolar disorder (BD) and other mood disorders. These hypotheses include disruptions in monoamine transmission, HPA axis function, immune function, neurogenesis, mitochondrial dysfunction and neuropeptide signaling (to name a few). Nearly all people suffering from mood disorders have significant disrup...

  8. Oral Perceptions of Fat and Taste Stimuli Are Modulated by Affect and Mood Induction

    Platte, Petra; Herbert, Cornelia; Pauli, Paul; Breslin, Paul A.S.

    2013-01-01

    This study examined the impact of three clinical psychological variables (non-pathological levels of depression and anxiety, as well as experimentally manipulated mood) on fat and taste perception in healthy subjects. After a baseline orosensory evaluation, ‘sad’, ‘happy’ and ‘neutral’ video clips were presented to induce corresponding moods in eighty participants. Following mood manipulation, subjects rated five different oral stimuli, appearing sweet, umami, sour, bitter, fatty, which were ...

  9. Development and initial validation of the Music Mood-Regulation Scale (MMRS)

    Hewston, RM; Lane, AM; Karageorghis, CI

    2008-01-01

    This study designed a measure to assess the perceived effectiveness of music as a strategy to regulate mood among a sport and exercise population. A strategy of assessing and comparing the integrity of competing hypotheses to explain the underlying factor structure of the scale was used. A 21-item Music Mood-Regulation Scale (MMRS) was developed to assess the extent to which participants used music to alter the mood states of anger, calmness, depression, fatigue, happiness, tension, and vigor...

  10. Emotional intelligence and mood states associated with optimal performance

    Lane, A; Thelwell, Richard; Devonport, T.

    2009-01-01

    This study utilized a within-subject design to investigate relationships between emotional intelligence and memories of mood states associated with optimal and dysfunctional performance in competitive sport and academic situations. Sport students (N = 436) completed a self-report Emotional Intelligence Scale (EIS), whilst retrospective accounts of mood states associated with optimal and dysfunctional sporting competition and academic examination performance were recorded using the Brunel Mood...

  11. The Relationship between Mood State, Interpersonal Attitudes and Psychological Distress in Stroke Patients

    Turner, Margaret A.; Andrewes, David G.

    2010-01-01

    This study investigated whether increasing positive mood improved interpersonal attitudes and relieved depression in depressed stroke patients despite levels of cognitive and emotional dysfunction. Depressed stroke (n = 30) and rheumatic/orthopaedic controls (n = 30) were compared on the effect of verbal and nonverbal positive and neutral mood


  12. Gut microbiota in autism and mood disorders

    Mangiola, Francesca; Ianiro, Gianluca; Franceschi, Francesco; Fagiuoli, Stefano; Gasbarrini, Giovanni; Gasbarrini, Antonio

    2016-01-01

    The hypothesis of an important role of gut microbiota in the maintenance of physiological state into the gastrointestinal (GI) system is supported by several studies that have shown a qualitative and quantitative alteration of the intestinal flora in a number of gastrointestinal and extra-gastrointestinal diseases. In the last few years, the importance of gut microbiota impairment in the etiopathogenesis of pathology such as autism, dementia and mood disorder, has been raised. The evidence of the inflammatory state alteration, highlighted in disorders such as schizophrenia, major depressive disorder and bipolar disorder, strongly recalls the microbiota alteration, highly suggesting an important role of the alteration of GI system also in neuropsychiatric disorders. Up to now, available evidences display that the impairment of gut microbiota plays a key role in the development of autism and mood disorders. The application of therapeutic modulators of gut microbiota to autism and mood disorders has been experienced only in experimental settings to date, with few but promising results. A deeper assessment of the role of gut microbiota in the development of autism spectrum disorder (ASD), as well as the advancement of the therapeutic armamentarium for the modulation of gut microbiota is warranted for a better management of ASD and mood disorders. PMID:26755882

  13. Progressive multiple sclerosis and mood disorders.

    Lorefice, Lorena; Fenu, G; Trincas, G; Moro, M F; Frau, J; Coghe, G C; Cocco, E; Marrosu, M G; Carta, M G

    2015-09-01

    Mood disorders are very common among multiple sclerosis (MS) patients, but their frequency in patients with progressive course (PMS) has not been adequately researched. Our study aimed to determine the frequency of mood disorders among patients with PMS compared with those with relapsing-remitting MS (RMS) and to explore the associations with disability and disease duration. The study included consecutive outpatients affected by MS according the 2010 revised Mc Donald diagnostic criteria. Psychiatric diagnoses were determined according to DSM-IV by psychiatrists using structured interview tools (ANTAS-SCID). Demographic and clinical data of patients were also collected. Disease courses were defined according to the re-examined phenotype descriptions by the Committee and MS Phenotype Group. Intergroup comparisons were performed by Chi-square test, while logistic regression analysis was performed to assess possible factors associated with mood disorders. In total, 240 MS patients (167 women) were enrolled; of these, 18 % (45/240) had PMS. The lifetime DSM-IV major depression diagnosis (MDD) was established in 40 and 23 % of the PMS and RMS patients, respectively. Using logistic regression analysis, the presence of MDD was independent from disease duration and disability and dependent on PMS course (P = 0.02; OR 2.2). Patients with PMS presented with MDD more frequently than those with RMS, independently from disease duration and physical disability. These findings highlight the importance of considering mood disorders, especially MDD, in the management of PMS patients. PMID:25899424

  14. Mood disorders and complementary and alternative medicine: a literature review

    Qureshi NA

    2013-05-01

    Full Text Available Naseem Akhtar Qureshi,1 Abdullah Mohammed Al-Bedah21General Administration for Research and Studies, Sulaimania Medical Complex, 2National Center for Complementary and Alternative Medicine, Ministry of Health, Riyadh, Saudi ArabiaAbstract: Mood disorders are a major public health problem and are associated with considerable burden of disease, suicides, physical comorbidities, high economic costs, and poor quality of life. Approximately 30%–40% of patients with major depression have only a partial response to available pharmacological and psychotherapeutic interventions. Complementary and alternative medicine (CAM has been used either alone or in combination with conventional therapies in patients with mood disorders. This review of the literature examines evidence-based data on the use of CAM in mood disorders. A search of the PubMed, Medline, Google Scholar, and Quertile databases using keywords was conducted, and relevant articles published in the English language in the peer-reviewed journals over the past two decades were retrieved. Evidence-based data suggest that light therapy, St John's wort, Rhodiola rosea, omega-3 fatty acids, yoga, acupuncture, mindfulness therapies, exercise, sleep deprivation, and S-adenosylmethionine are effective in the treatment of mood disorders. Clinical trials of vitamin B complex, vitamin D, and methylfolate found that, while these were useful in physical illness, results were equivocal in patients with mood disorders. Studies support the adjunctive role of omega-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid in unipolar and bipolar depression, although manic symptoms are not affected and higher doses are required in patients with resistant bipolar depression and rapid cycling. Omega-3 fatty acids are useful in pregnant women with major depression, and have no adverse effects on the fetus. Choline, inositol, 5-hydroxy-L-tryptophan, and N-acetylcysteine are effective adjuncts in bipolar patients. Dehydroepiandrosterone is effective both in bipolar depression and depression in the setting of comorbid physical disease, although doses should be titrated to avoid adverse effects. Ayurvedic and homeopathic therapies have the potential to improve symptoms of depression, although larger controlled trials are needed. Mind-body-spirit and integrative medicine approaches can be used effectively in mild to moderate depression and in treatment-resistant depression. Currently, although CAM therapies are not the primary treatment of mood disorders, level 1 evidence could emerge in the future showing that such treatments are effective.Keywords: complementary and alternative medicine, mood disorders, Ayurveda, homeopathy, integrative medicine

  15. Postpartum depression: Etiology, treatment and consequences for maternal care.

    Brummelte, Susanne; Galea, Liisa A M

    2016-01-01

    This article is part of a Special Issue "Parental Care". Pregnancy and postpartum are associated with dramatic alterations in steroid and peptide hormones which alter the mothers' hypothalamic pituitary adrenal (HPA) and hypothalamic pituitary gonadal (HPG) axes. Dysregulations in these endocrine axes are related to mood disorders and as such it should not come as a major surprise that pregnancy and the postpartum period can have profound effects on maternal mood. Indeed, pregnancy and postpartum are associated with an increased risk for developing depressive symptoms in women. Postpartum depression affects approximately 10-15% of women and impairs mother-infant interactions that in turn are important for child development. Maternal attachment, sensitivity and parenting style are essential for a healthy maturation of an infant's social, cognitive and behavioral skills and depressed mothers often display less attachment, sensitivity and more harsh or disrupted parenting behaviors, which may contribute to reports of adverse child outcomes in children of depressed mothers. Here we review, in honor of the "father of motherhood", Jay Rosenblatt, the literature on postnatal depression in the mother and its effect on mother-infant interactions. We will cover clinical and pre-clinical findings highlighting putative neurobiological mechanisms underlying postpartum depression and how they relate to maternal behaviors and infant outcome. We also review animal models that investigate the neurobiology of maternal mood and disrupted maternal care. In particular, we discuss the implications of endogenous and exogenous manipulations of glucocorticoids on maternal care and mood. Lastly we discuss interventions during gestation and postpartum that may improve maternal symptoms and behavior and thus may alter developmental outcome of the offspring. PMID:26319224

  16. Music feels like moods feel

    KrisGoffin

    2014-01-01

    While it is widely accepted that music evokes moods, there is disagreement over whether music-induced moods are relevant to the aesthetic appreciation of music as such. The arguments against the aesthetic relevance of music-induced moods are: (1) moods cannot be intentionally directed at the music and (2) music-induced moods are highly subjective experiences and are therefore a kind of mind-wandering. This paper presents a novel account of musical moods that avoids these objections. It is cor...

  17. Cognitive schemas as longitudinal predictors of self-reported adolescent depressive symptoms and resilience.

    Friedmann, Jordan S; Lumley, Margaret N; Lerman, Bethany

    2016-01-01

    Given that depression risk intensifies in adolescence, examining associates of depressive symptoms during the shift from childhood to adolescence is important for expanding knowledge about the etiology of depression symptoms and disorder. A longitudinal youth report was employed to examine the trajectory of both the content and structure of positive and negative schemas in adolescence and also whether these schemas could prospectively predict depressive symptoms and youth-reported resilience. One hundred and ninety-eight participants (aged 9 to 14) were recruited from four schools to complete measures of youth depressive symptoms, resilience, and schema content and structure. Those who consented to a follow-up study completed the same measures online (50 participants completed). Negative and positive schema content and structure were related over time. After controlling depressive symptoms/resilience at Time 1, negative schema content was the only significant predictor (trend level) of depressive symptoms and resilience at Time 2. Implications for cognitive theories and clinical practice are discussed. PMID:26681480

  18. Explicit and implicit information needs of people with depression: a qualitative investigation of problems reported on an online depression support forum

    Banfield Michelle A

    2011-05-01

    Full Text Available Abstract Background Health management is impeded when consumers do not possess adequate knowledge about their illness. At a public health level, consumer knowledge about depression is particularly important because depression is highly prevalent and causes substantial disability and burden. However, currently little is known about the information needs of people with depression. This study aimed to investigate the explicit and implicit information needs of users of an online depression support forum. Methods A sample of 2680 posts was systematically selected from three discussion forums on an online depression bulletin board (blueboard.anu.edu.au. Data were examined for evidence of requests for information (reflecting explicit needs and reports of past or current problems (implicit needs. Thematic analysis was conducted using a data-driven inductive approach with the assistance of NVivo 7, and instances of questions and people reporting particular types of problems were recorded. Results A total of 134 participants with personal experience of depression contributed to the data analysed. Six broad themes represented participant queries and reported problems: Understanding depression; disclosure and stigma; medication; treatment and services; coping with depression; and comorbid health problems. A variety of specific needs were evident within these broad thematic areas. Some people (n = 46 expressed their information needs by asking direct questions (47 queries but the majority of needs were expressed implicitly (351 problems by the 134 participants. The most evident need for information related to coping with depression and its consequences, followed by topics associated with medication, treatment and services. Conclusions People with depression have substantial unmet information needs and require strategies to deal with the difficulties they face. They require access to high quality and relevant online resources and professionals; thus, there is a need to rectify current gaps in the provision of information and limitations of dissemination. Greater knowledge about depression and its treatment is also needed at the general community level.

  19. Aerobic and resistance training improves mood state among adults living with HIV.

    Jaggers, J R; Hand, G A; Dudgeon, W D; Burgess, S; Phillips, K D; Durstine, J L; Blair, S N

    2015-02-01

    The purpose of this investigation was to examine the effects of combined aerobic and resistance exercise training among self-reported mood disturbances, perceived stress, frequency of self-reported symptoms, and symptom distress in a sample of HIV+ adults. For this purpose, 49 participants were randomly assigned into an exercise (EX) or control (CON) group. Those in the EX group completed 50 min of supervised aerobic and resistance training at a moderate intensity twice a week for 6 weeks. The CON group reported to the university and engaged in sedentary activities. Data were collected at baseline before randomization and 6 weeks post intervention. Measures included the symptom distress scale (SDS), perceived stress scale (PSS), profile of mood states (POMS) total score, and the POMS sub-scale for depression and fatigue. A 2 way ANOVA was used to compare between and within group interactions. The EX group showed a significant decrease in reported depression scores (p=0.03) and total POMS (p=0.003). The CON group reported no change in POMS or SDS, but showed a significant increase in PSS. These findings indicate that combination aerobic and resistance training completed at a moderate intensity at least twice a week provides additional psychological benefits independent of disease status and related symptoms. PMID:25322262

  20. Reported Food Choices in Older Women in Relation to BMI and Depressive Symptoms

    Robert W. Jeffery; Linde, Jennifer A.; Gregory E. Simon; Ludman, Evette J; Rohde, Paul; Ichikawa, Laura E.; Finch, Emily A.

    2008-01-01

    This paper examines the relationships among reports of depressive symptoms, BMI and frequency of consumption of 30 foods in 4,655 middle-aged women. Food was grouped into three categories: high-calorie sweet, high-calorie nonsweet, and low calorie. Controlling for total energy intake, BMI and depressive symptoms were both inversely associated with a higher frequency of consumption of low-calorie foods. BMI was positively associated with consumption of high-calorie nonsweet foods and negativel...

  1. The Relationships of Personality and Cognitive Styles with Self-Reported Symptoms of Depression and Anxiety

    Sutton, Jonathan M.; Mineka, Susan; Zinbarg, Richard E; Craske, Michelle G; Griffith, James W; Rose, Raphael D.; Allison M. Waters; Nazarian, Maria; Mor, Nilly

    2010-01-01

    Many studies have reported concurrent relationships between depressive symptoms and various personality, cognitive, and personality-cognitive vulnerabilities, but the degree of overlap among these vulnerabilities is unclear. Moreover, whereas most investigations of these vulnerabilities have focused on depression, their possible relationships with anxiety have not been adequately examined. The present study included 550 high school juniors and examined the cross-sectional relationships among ...

  2. High serum testosterone levels during postpartum period are associated with postpartum depression.

    Aswathi, A; Rajendiren, Soundravally; Nimesh, Archana; Philip, R Ravi; Kattimani, Shivanand; Jayalakshmi, D; Ananthanarayanan, P H; Dhiman, Pooja

    2015-10-01

    In view of the reported cases of mood disorders that occur in mothers following childbirth and believing that sex steroid hormones contribute to mood and behavioral changes, this study has been aimed to explore the role of sex steroid hormones as an etiological factor for postpartum depression (PPD). This study was conducted at JIPMER, Puducherry, India between January 2010 and 2011. 103 women were recruited in the study after childbirth, out of which 62 women who were believed to be suffering from PPD were categorized as cases and the remaining 41 with no mood changes as controls, using Edinburgh Postpartum Depression Scale (EPDS) (cases had EPDS score ?10 at 24-28h, controls had score women following childbirth and PPD. PMID:26372084

  3. Magnetic seizure therapy in an adolescent with refractory bipolar depression: a case report

    Noda Y

    2014-10-01

    Full Text Available Yoshihiro Noda,1,2 Zafiris J Daskalakis,1–3 Jonathan Downar,4 Paul E Croarkin,5 Paul B Fitzgerald,6 Daniel M Blumberger1–3 1Department of Psychiatry, Faculty of Medicine, University of Toronto, 2Temerty Centre for Therapeutic Brain Intervention, 3Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 4MRI-Guided rTMS Clinic, University Health Network, Toronto, ON, Canada; 5Division of Child and Adolescent Psychiatry, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA; 6Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne, Australia Abstract: Magnetic seizure therapy (MST has shown efficacy in adult patients with treatment-resistant depression with limited impairment in memory. To date, the use of MST in adolescent depression has not been reported. Here we describe the first successful use of MST in the treatment of an adolescent patient with refractory bipolar depression. This patient received MST in an ongoing open-label study for treatment-resistant major depression. Treatments employed a twin-coil MST apparatus, with the center of each coil placed over the frontal cortex (ie, each coil centered over F3 and F4. MST was applied at 100 Hz and 100% machine output at progressively increasing train durations. Depressive symptoms were assessed using the 24-item Hamilton Depression Rating Scale and cognitive function was assessed with a comprehensive neuropsychological battery. This adolescent patient achieved full remission of clinical symptoms after an acute course of 18 MST treatments and had no apparent cognitive decline, other than some autobiographical memory impairment that may or may not be related to the MST treatment. This case report suggests that MST may be a safe and well tolerated intervention for adolescents with treatment-resistant bipolar depression. Pilot studies to further evaluate the effectiveness and safety of MST in adolescents warrant consideration. Keywords: brain stimulation, treatment-resistant depression, adolescent depression, cognitive effects

  4. Postpartum depresyon görĂŒlme sıklığı ve tarama yöntemleri [The prevalence and screening methods of postpartum depression

    Erdem, ÖzgĂŒr; Bucaktepe, P. Gamze Erten

    2012-01-01

    Postpartum Depression is the most common complication of the delivery and affects approximately 10%-15% of women who had just gave birth. During a period in which women believe that they should be happy, the depressive mood experienced by most women leads to feelings of guilt, hiding the symptoms, and postpartum depression to be overlooked. Although the incidence of serious psychiatric disorders during pregnancy is low, it is reported that the incidence shows a dramatic increase during the po...

  5. Mood Change of English, French and Chinese Immigrants in Ottawa-Gatineau Region, Canada

    Ning Tang

    2014-12-01

    Full Text Available This multicultural study aimed at examining moodchange of English, French and Chinese speaking immigrants in Ottawa-Gatineau Region, Canada, and identifying demographic factors that impact the change. 810 immigrants of English, French and Chinese speaking sub-groupswere recruited by purposive-sampling. Using self-reports, respondents answered questions regarding moodchange (moodstatus change and mood belief change and demography in Multicultural Lifestyle Change Questionnaire of English, French or Chinese version. Data were analyzed statistically for the different immigrant sub-groups. Immigrants of different gender, language and category sub-groups exhibited different Mood Change Rates, Mood Improving Rates,Mood Declining Rates and MoodBelief Change Rates. There was no statistical difference between the ratesof immigrant sub-groups.Mood Change (MoodStatus Change + MoodBelief Change was correlated positively with Mother Tongue and negatively with Speaking Languages. Mood Status  Change was negatively correlated with Marital Status and Highest Level of Education. Mother Tongue, Speaking Languages and Highest Level of Education significantly impacted MoodChange (Mood Status Change + Mood Belief Change. Marital Status and Highest Level of Education significantly influenced Mood Status Change. Immigrants of different sub-groups in Canada experienceddifferentmoodchanges. Marital Status and Highest Level of Educationwerethe main factors impacting Mood Status Change. Mother Tongue and Speaking Languages werethe principal factors influencing Mood Belief Change. Culture was an important factor contributing Mood Change. Acculturation could impact Mood Status Change and Mood Belief Change. Data of immigrant mood change can provide evidence for health policy-making and policy-revising in Canada.

  6. Sleep and perinatal mood disorders: a critical review

    Ross, Lori E.; Murray, Brian J.; Steiner, Meir

    2005-01-01

    Pregnancy and the postpartum period are recognized as times of vulnerability to mood disorders, including postpartum depression and psychosis. Recently, changes in sleep physiology and sleep deprivation have been proposed as having roles in perinatal psychiatric disorders. In this article we review what is known about changes in sleep physiology and behaviour during the perinatal period, with a focus on the relations between sleep and postpartum “blues,” depression and psychosis and on sleep-...

  7. Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis

    Lehmann, Michael L.; Brachman, Rebecca A.; Martinowich, Keri; Schloesser, Robert J.; Herkenham, Miles

    2013-01-01

    Both social defeat stress and environmental enrichment stimulate adrenal glucocorticoid secretion, but they have opposing effects on hippocampal neurogenesis and mood. Hypothalamic-pituitary-adrenal (HPA) axis dysregulation and decreased neurogenesis are consequences of social defeat. These outcomes are correlated with depressive states, but a causal role in the etiology of depression remains elusive. The antidepressant actions of environmental enrichment are neurogenesis-dependent, but the c...

  8. Three types of self-efficacy associated with medication adherence in patients with co-occurring HIV and substance use disorders, but only when mood disorders are present

    Reif S

    2013-06-01

    Full Text Available Susan Reif,1 Rae Jean Proeschold-Bell,1,2 Jia Yao,1 Sara LeGrand,1,2 Anna Uehara,2 Edgar Asiimwe,2 Evelyn Byrd Quinlivan31Duke Center for Health Policy and Inequalities Research, 2Duke Global Health Institute, Duke University, Durham, NC, 3Center for Infectious Diseases, University of North Carolina Chapel Hill, Chapel Hill, NC, USABackground: Adherence with medication regimens for human immunodeficiency virus (HIV is a life-saving behavior for people with HIV infection, yet adherence is challenging for many individuals with co-occurring substance use and/or mood disorders. Medication-taking self-efficacy, which is the confidence that one can take one's medication as prescribed, is associated with better adherence with HIV medication. However, little is known about the influence that other kinds of self-efficacy have on adherence with HIV medication, especially among HIV-infected individuals with co-occurring substance use and/or mood disorders. We sought to examine the relationship between adherence with HIV medication among substance users and three specific kinds of self-efficacy, ie, one's confidence that one can communicate with medical providers, get support, and manage one's mood. We further sought to examine whether symptoms of depression and anxiety moderate these relationships.Methods: Patients were recruited from three HIV clinics in the southeastern United States as part of an integrated study of treatment for HIV and substance use.Results: We interviewed 154 patients with HIV and substance use who reported taking HIV medications. Based on symptoms of depression and anxiety using the Patient Health Questionnaire-9 and the Hospital Anxiety and Depression Scale-Anxiety, 63% had probable depression and/or anxiety. Higher levels of self-efficacy in provider communication (ÎČ = 3.86, P < 0.01, getting needed support (ÎČ = 2.82, P < 0.01, and mood management (ÎČ = 2.29, P < 0.05 were related to better self-reported adherence with HIV medication among study participants with probable depression and/or anxiety. The three kinds of self-efficacy were not associated with medication adherence among participants with HIV and substance use only.Conclusion: In the search for mutable factors to improve medication adherence among individuals triply diagnosed with HIV, substance use, and mood disorders, these findings support previous research indicating the benefit of enhancing self-efficacy, and further point to three specific kinds of self-efficacy that may benefit medication adherence, ie, provider communication, getting support, and mood management.Keywords: human immunodeficiency virus, self-efficacy, substance use, depression, anxiety, interventions

  9. Mood response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease.

    Campbell, Meghan C; Black, Kevin J; Weaver, Patrick M; Lugar, Heather M; Videen, Tom O; Tabbal, Samer D; Karimi, Morvarid; Perlmutter, Joel S; Hershey, Tamara

    2012-01-01

    Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) improves motor functioning but has variable effects on mood. Little is known about the relationship between electrode contact location and mood response. The authors identified the anatomical location of electrode contacts and measured mood response to stimulation with the Visual Analog Scale in 24 STN DBS PD patients. Participants reported greater positive mood and decreased anxiety and apathy with bilateral and unilateral stimulation. Left DBS improved mood more than right DBS. Right DBS-induced increase in positive mood was related to more medial and dorsal contact locations. These results highlight the functional heterogeneity of the STN. PMID:22450611

  10. Resilience and Unemployment: Exploring Risk and Protective Influences for the Outcome Variables of Depression and Assertive Job Searching

    Moorhouse, Anne; Caltabiano, Marie L.

    2007-01-01

    This study examined adult resilience in the context of the adversity of unemployment. Seventy-seven unemployed job seekers completed a self-report survey containing the Resilience Scale (G. M. Wagnild & H. M. Young, 1993), Centre for Epidemiologic Studies-Depressed Mood Scale (L. S. Radloff, 1977), and the Assertive Job Hunting Survey (H. A.


  11. Demand Characteristics, Moods, and Helping

    Wispe, Lauren; And Others

    1977-01-01

    Procedures used in empathy-helping studies suggest results may be due to demand characteristics. Two studies were run to investigate especially the mood induction process. One reproduced the Aderman-Berkowitz main mood effects. Another showed that after seeing a help-non-help incident, mood effects were demonstrated only when Ss knew the research


  12. Computerized ambulatory monitoring in mood disorders: feasibility, compliance, and reactivity.

    Husky, Mathilde M; Gindre, Claire; Mazure, Carolyn M; Brebant, Catherine; Nolen-Hoeksema, Susan; Sanacora, Gerard; Swendsen, Joel

    2010-07-30

    Patients with depression (n=20) or bipolar disorder (n=21) completed computerized ambulatory monitoring for three consecutive days. Results indicate satisfactory rates of acceptance and compliance, with no salient fatigue effects. However, some evidence for reactive effects was found. The findings provide support for this approach in the study of mood disorders. PMID:20488558

  13. Interaction between Personality and Mood in Unipolar and Bipolar Patients.

    Alexander, Gene E.; And Others

    Much of the literature on affective disorders has been devoted to categorizing, assessing, and treating the mood and behavioral symptoms typically associated with depressive illness, and much research has studied how personality traits interact with these state symptoms. The personality scales of the Millon Clinical Multiaxial Inventory (MCMI) are


  14. Vitamins, Minerals, and Mood

    Kaplan, Bonnie J.; Crawford, Susan G.; Field, Catherine J.; Simpson, J. Steven A.

    2007-01-01

    In this article, the authors explore the breadth and depth of published research linking dietary vitamins and minerals (micronutrients) to mood. Since the 1920s, there have been many studies on individual vitamins (especially B vitamins and Vitamins C, D, and E), minerals (calcium, chromium, iron, magnesium, zinc, and selenium), and vitamin-like


  15. Genetic biomarkers of depression

    Anand Tamatam

    2012-01-01

    Full Text Available Depression is a term that has been used to describe a variety of ailments, ranging from minor to incapacitating. Clinically significant depression, termed as major depression, is a serious condition characterized not only by depressed mood but also by a cluster of somatic, cognitive, and motivational symptoms. Significant research efforts are aimed to understand the neurobiological as well as psychiatric disorders, and the evaluation of treatment of these disorders is still based solely on the assessment of symptoms. In order to identify the biological markers for depression, we have focused on gathering information on different factors responsible for depression including stress, genetic variations, neurotransmitters, and cytokines and chemokines previously suggested to be involved in the pathophysiology of depression. The present review illustrates the potential of biomarker profiling for psychiatric disorders, when conducted in large collections. The review highlighted the biomarker signatures for depression, warranting further investigation.

  16. Yoga in Public School Improves Adolescent Mood and Affect

    Felver, Joshua C.; Butzer, Bethany; Olson, Katherine J.; Smith, Iona M.; Khalsa, Sat Bir S.

    2015-01-01

    The purpose of the present study was to directly compare the acute effects of participating in a single yoga class versus a single standard physical education (PE) class on student mood. Forty-seven high school students completed self-report questionnaires assessing mood and affect immediately before and after participating in a single yoga class…

  17. Development and Initial Psychometrics of the Korean Mood State Inventory

    Lee, Sang Min; Moon, Kyoung-Suk; Puig, Ana; Cho, Eunsoo; Lee, Sun Young; Back, Sun Hee; Woo, Yeon Kyoung

    2008-01-01

    The authors describe the development and psychometric properties of the Korean Mood State Inventory (KMSI), which is designed to measure the mood states of Korean college students. Factor structure, concurrent validity, and internal consistency of the KMSI scores are reported. Implications, limitations, and recommendations for future research are…

  18. Bupropion XL use in comorbidity of depression and restless leg syndrome: a case report

    onur durmaz

    2014-01-01

    Full Text Available Restless leg syndrome (RLS is a sensorimotor disorder with symptoms including uncomfortable subjective sensations in the legs and the urge to move them. This common disorder affects 10% of the population and may reduce quality of life. The pathophysiology of RLS is not well understood but dysfunction of dopaminergic pathways is the most prominent theory. Antidepressants, especially SSRIs, can aggravate the symptoms of RLS. Here we present a 42 year old woman diagnosed with major depressive disorder and comorbid RLS and who had been treated with paroxetine 20 mg/day for 2 months who benefited from switching to bupropion treatment. In this case the RLS symptoms had existed for approximately 3 years but were milder before paroxetine treatment. The patient met the diagnostic criteria for RLS. We used the International Restless Legs Scale (IRLS and Montgomery-Asberg Depression Rating Scale (MADRS to measure the patient’s symptom severity. The severity of her depressive symptoms was similar to baseline despite the two month paroxetine treatment. Due to symptoms of RLS and her ongoing depressive complaints, we decided to switch from paroxetine to bupropion. With 150 mg/day bupropion XL treatment, her RLS symptoms improved substantially at a one month follow-up while her depression severity was not changed significantly. Due to inadequate response for depression, bupropion XL was titrated to 300 mg/day. Her depressive symptoms improved significantly at a further one month follow-up. Comorbidity of RLS and depression was found to be as a frequent occurence reported in the literature. We concluded that bupropion, as a selective noradrenergic-dopaminergic reuptake inhibitor can be a good alternative to the SSRIs for patients, who suffer from both depression and RLS.

  19. Stress in women with postpartum depression: a phenomenological study

    Arthur, DG; Martinson, IM; Leung, SSK

    2005-01-01

    AIM: The aim of this paper is to report a study of the lived experience of postpartum stress among depressed Hong Kong Chinese mothers. BACKGROUND: Research consistently relates postpartum stress to the mood and well-being of mothers during the postpartum period. While several studies have used questionnaires to assess the stress levels of mothers or have identified stressors by asking them to list stressful events, the existing literature lacks in-depth information on the lived experience of...

  20. Mood disorders and complementary and alternative medicine: a literature review.

    Qureshi, Naseem Akhtar; Al-Bedah, Abdullah Mohammed

    2013-01-01

    Mood disorders are a major public health problem and are associated with considerable burden of disease, suicides, physical comorbidities, high economic costs, and poor quality of life. Approximately 30%-40% of patients with major depression have only a partial response to available pharmacological and psychotherapeutic interventions. Complementary and alternative medicine (CAM) has been used either alone or in combination with conventional therapies in patients with mood disorders. This review of the literature examines evidence-based data on the use of CAM in mood disorders. A search of the PubMed, Medline, Google Scholar, and Quertile databases using keywords was conducted, and relevant articles published in the English language in the peer-reviewed journals over the past two decades were retrieved. Evidence-based data suggest that light therapy, St John's wort, Rhodiola rosea, omega-3 fatty acids, yoga, acupuncture, mindfulness therapies, exercise, sleep deprivation, and S-adenosylmethionine are effective in the treatment of mood disorders. Clinical trials of vitamin B complex, vitamin D, and methylfolate found that, while these were useful in physical illness, results were equivocal in patients with mood disorders. Studies support the adjunctive role of omega-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid in unipolar and bipolar depression, although manic symptoms are not affected and higher doses are required in patients with resistant bipolar depression and rapid cycling. Omega-3 fatty acids are useful in pregnant women with major depression, and have no adverse effects on the fetus. Choline, inositol, 5-hydroxy-L-tryptophan, and N-acetylcysteine are effective adjuncts in bipolar patients. Dehydroepiandrosterone is effective both in bipolar depression and depression in the setting of comorbid physical disease, although doses should be titrated to avoid adverse effects. Ayurvedic and homeopathic therapies have the potential to improve symptoms of depression, although larger controlled trials are needed. Mind-body-spirit and integrative medicine approaches can be used effectively in mild to moderate depression and in treatment-resistant depression. Currently, although CAM therapies are not the primary treatment of mood disorders, level 1 evidence could emerge in the future showing that such treatments are effective. PMID:23700366

  1. Biological rhythm disturbances in mood disorders.

    Wirz-Justice, Anna

    2006-02-01

    From earliest times, psychiatrists have described biological rhythm disturbances as characteristic of mood disorders. The present flourishing of circadian biology has revealed the molecular basis of 24-h rhythmicity driven by 'clock' genes, as well as the importance of zeitgebers (synchronisers). Winter depression was first modelled on regulation of animal behaviour by seasonal changes in daylength, and led to application of light as the first successful chronobiological treatment in psychiatry. Light therapy has great promise for many other disorders (e.g. sleep-wake cycle disturbances in Alzheimer's dementia, bulimia, premenstrual disorder, depression during pregnancy) and, importantly, as an adjuvant to antidepressant medication in major non-seasonal depression. The pineal hormone melatonin is also a zeitgeber for the human circadian system, in addition to possessing direct sleep-promoting effects. Chronobiology has provided efficacious non-pharmaceutical treatments for mood disorders (such as sleep deprivation or light therapy) as well as novel approaches to new drugs (e.g. agomelatine). PMID:16436934

  2. Smoking Cessation with E-Cigarettes in Smokers with a Documented History of Depression and Recurring Relapses

    Pasquale Caponnetto; Riccardo Polosa; Roberta Auditore; Cristina Russo; Davide Campagna

    2011-01-01

    The association between nicotine dependence and affective disorders, particularly major depressive disorder (MDD), is well known with high prevalence rates being reported for smokers. The reason for this association is not clear, but, it has been argued that smoking may help individuals to cope with stress or medicate depressed mood. Smoking cessation programs are useful in helping smokers to quit, but smoking is a very difficult addiction to break, especially for people suffering from depres...

  3. Mindfulness significantly reduces self-reported levels of anxiety and depression

    WĂŒrtzen, Hanne; Dalton, Susanne Oksbjerg; Elsass, Peter; Sumbundu, Antonia Dorthea; Steding-Jensen, Marianne; Karlsen, Randi ValbjĂžrn; Andersen, Klaus Kaae; Flyger, Henrik L; Pedersen, Anne E.; Johansen, Christoffer

    2013-01-01

    INTRODUCTION: As the incidence of and survival from breast cancer continue to raise, interventions to reduce anxiety and depression before, during and after treatment are needed. Previous studies have reported positive effects of a structured 8-week group mindfulness-based stress reduction program...... (MBSR) among patients with cancer and other conditions. PURPOSE: To test the effect of such a programme on anxiety and depression among women with breast cancer in a population-based randomised controlled study. METHODS: A total of 336 women who had been operated on for breast cancer (stage I-III) were...... randomised to usual care or MBSR+usual care. Questionnaires including the Symptom Checklist-90r anxiety and depression subscales and the Center for Epidemiological Studies-Depression scale were administered before randomisation and immediately, 6 and 12 months after the intervention. RESULTS: Intention...

  4. Patient-reported depression measures in cancer: a meta-review.

    Wakefield, Claire E; Butow, Phyllis N; Aaronson, Neil A; Hack, Thomas F; Hulbert-Williams, Nicholas J; Jacobsen, Paul B

    2015-07-01

    The patient-reported depression measures that perform best in oncology settings have not yet been identified. We did a meta-review to integrate the findings of reviews of more than 50 depression measures used in adults with, or recovering from, any type of cancer. We searched Medline, PsycINFO, Embase, and grey literature from 1999 to 2014 to identify 19 reviews representing 372 primary studies. 11 reviews were rated as being of high quality (defined as meeting at least 20 criteria in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement). The Hospital Anxiety Depression Scale (HADS) was the most thoroughly evaluated measure, but was limited by cutpoint variability. The HADS had moderate screening utility indices and was least recommended in advanced cancer or palliative care. The Beck Depression Inventory was more generalisable across cancer types and disease stages, with good indices for screening and case finding. The Center for Epidemiologic Studies Depression Scale was the best-weighted measure in terms of responsiveness. This meta-review provides a comprehensive overview of the strengths and limitations of available depression measures. It can inform the choice of the best measure for specific settings and purposes. PMID:26303561

  5. Atypical Depression

    Erhan Ertekin

    2013-09-01

    Full Text Available Atypical depression is defined as a specifier of major depressive disorder. Columbia criteria for atypical depression are commonly used to make a diagnosis. Female sex, onset at early age, chronic course, and higher rate of comorbidity (especially anxiety disorder and bipolar disorder is noteworthy in atypical depression. Although, the atypical depression seems to support the familial genetic transition, there is not any specific study supporting these data. In the treatment of atypical depression, monoamine oxidase inhibitors are reported to be more effective than tricyclic antidepressants. In recent studies, selective serotonin reuptake inhibitors have also proven to be efficient.

  6. Painful temporomandibular disorders, self reported tinnitus, and depression are highly associated

    Giovana Fernandes

    2013-12-01

    Full Text Available Objective The aim of this study was to investigate the association among painful temporomandibular disorders (TMD, self reported tinnitus, and levels of depression. Method The sample consisted of 224 individuals with ages ranges from 18 to 76 years. The Research Diagnostic Criteria for Temporomandibular Disorders Axis I were used to classify TMD and Axis II were used for self reported tinnitus, and to score the levels of depression. The odds ratio (OR with 95% confidence interval (CI was applied. Results The presence of painful TMD without tinnitus was significantly associated with moderate/severe levels of depression (OR=9.3, 95%; CI: 3.44-25.11. The concomitant presence of painful TMD and tinnitus self-report increased the magnitude of the association with moderate/severe levels of depression (OR=16.3, 95%; CI, 6.58-40.51. Conclusion Painful temporomandibular disorders, high levels of depression, and self reported tinnitus are deeply associated. However, this association does not imply a causal relationship.

  7. Adolescents with depressive symptoms and their challenges with learning in school.

    Humensky, Jennifer; Kuwabara, Sachiko A; Fogel, Joshua; Wells, Corrie; Goodwin, Brady; Van Voorhees, Benjamin W

    2010-10-01

    We examine school performance among 83 adolescents at risk for major depression. Negative mood interfered with subjective measures of school performance, including ability to do well in school, homework completion, concentrate in class, interact with peers, and going to class. No significant relationships were found for mood and objective measures of school performance (school attendance, English, and Math grades). Students with a college-educated parent had stronger performance in objective measures (school attendance and Math grades), whereas males had lower English grades. In qualitative interviews, adolescents reported that negative thinking led to procrastination, which led to poor school performance, which led to more negative thinking. Adolescents with depressive symptoms that do not meet the threshold for referral report struggles in school. Understanding the specific challenges faced by adolescents with even low levels of depressive symptoms can help school nurses, teachers, and parents identify appropriate interventions to help adolescents succeed in school. PMID:20606058

  8. MOOD DISTURBANCE DURING CYCLING PERFORMANCE AT EXTREME CONDITIONS

    Matthew Wilson

    2005-03-01

    Full Text Available The purpose of the study was to investigate the effects of extreme environments on mood state changes in hypoxic conditions and cold conditions in comparison to baseline conditions. The research design involved participants completing a two-hour stationary cycle ergometer ride at a simulated altitude of 2,500 metres, O°C, and normal laboratory conditions at a pace equivalent of lactate threshold. Eight male elite cyclists (Age: M = 26.23 yrs., SD = 6.74 completed the hypoxia- normal cycling trials. Ten male highly trained cyclists (Age: M = 23.34 yrs., SD = 5.45 participated in the cold-normal trials. Mood was assessed before, after one hour, and after two hours using the 24-item Brunel Mood Scale. MANOVA results indicated no significant interaction effect for mood changes over time by environment condition (Wilks' Lambda = .73, p = .32, Eta2 = .05, a significant main effect for mood changes over time (Wilks' Lambda = .61. p < .001, Partial Eta2 = .15 and a significant main effect for differences in mood by condition (Wilks' Lambda = .72, p < .000, Partial Eta2 = .15. Results indicated that increased anger, depression and fatigue were associated with performing at altitude, particularly after two hours of exercise. Collectively, results lend support to the notion that altitude is associated with negative mood states, although it should be noted that environment conditions did not affect the change in mood states over time. We suggest that further research is needed to explore mechanisms that individuals use to regulate negative mood during strenuous exercise.

  9. Talk Therapy May Help Depressed Teens Who Shun Antidepressants

    ... Talk Therapy May Help Depressed Teens Who Shun Antidepressants Cognitive behavioral therapy can help boost mood without ... 20, 2016 (HealthDay News) -- Depressed teens who refuse antidepressants may benefit from counseling, a new study suggests. ...

  10. The self-reported Montgomery-Åsberg depression rating scale is a useful evaluative tool in major depressive disorder

    Fantino Bruno

    2009-05-01

    Full Text Available Abstract Background The use of Patient-reported Outcomes (PROs as secondary endpoints in the development of new antidepressants has grown in recent years. The objective of this study was to assess the psychometric properties of the 9-item, patient-administered version of the Montgomery-Åsberg Depression Rating Scale (MADRS-S. Methods Data from a multicentre, double-blind, 8-week, randomised controlled trial of 278 outpatients diagnosed with Major Depressive Disorder were used to evaluate the validity, reliability and sensitivity to change of the MADRS-S using psychometric methods. A Receiver Operating Characteristic (ROC curve was plotted to identify the most appropriate threshold to define perceived remission. Results No missing values were found at the item level, indicating good acceptability of the scale. The construct validity was satisfactory: all items contributed to a common underlying concept, as expected. The correlation between MADRS-S and physicians' MADRS was moderate (r = 0.54, p Conclusion Taking account of patient's perceptions of the severity of their own symptoms along with the psychometric properties of the MADRS-S enable its use for evaluative purposes in the development of new antidepressant drugs.

  11. Congenital depressed skull fracture in the absence of trauma: case report and literature review

    Tovar-Spinoza ZS

    2012-02-01

    Full Text Available Zulma S Tovar-Spinoza, Peter D KimDepartment of Neurosurgery, SUNY Upstate Medical University, Syracuse NYAbstract: There are limited reports of neonatal depressed skull fractures in the absence of any known trauma or obvious risk factors. Here we describe a male neonate with a significant frontal nontraumatic depressed fracture, his course of treatment, and a literature review. A male neonate was attended for a significant congenital depressed skull fracture in the left frontal bone. He was born full term after an uncomplicated delivery to a multiparous mother who was a human immunodeficiency syndrome (HIV-positive immigrant from sub-Saharan Africa. The pregnancy was otherwise uncomplicated. There was no history of trauma to the mother during the pregnancy or delivery. Ultrasonography had been unremarkable. No other abnormalities were noted. The patient was brought to the operating room at the age of 13 days for elevation of his fracture due to its nonreducible nature. A small linear incision was made just posterior to the coronal suture. The dura mater was stripped and a combination of Penfield and periostial elevators was used to elevate the depressed fracture. Nontraumatic depressed skull fractures are uncommon in neonates. The cause of this entity has not been identified, and many theories about its origin have been proposed. Treatment can be either surgical or conservative.Keywords: neonatal, congenital, depressed fracture, spontaneous, nontraumatic

  12. Mood States as Predictors of Characteristics and Precipitants of Suicidality among College Students

    Hess, Elaine A.; Becker, Martin A.; Pituch, Keenan A.; Saathoff, Andrea K.

    2011-01-01

    This article examines college students' self-reported mood states during a suicidal crisis and the relationship between mood and indicators of suicidality. Multilevel modeling demonstrated that the moods of hopelessness and anger predicted stronger intent; anxiety/worry predicted weaker thoughts of suicide; hopelessness increased the odds of…

  13. Mood congruity and episodic memory in young children.

    Christodoulou, Joan; Burke, Deborah M

    2016-02-01

    Although mood congruity effects on episodic memory have been reported extensively in adults, they have not been reported for children younger than 10years. The current research investigated mood congruity effects in story recall using an embodied approach to mood induction involving a facial manipulation task with 3- and 4-year-old children. Participants held a chopstick or a popsicle stick in their mouths in a way to either produce or inhibit a smile while they listened to a story featuring happy events for a happy character and sad events for a sad character. Children's mood ratings before and after mood induction indicated that mood became more positive in the smile condition, with no change in the no smile condition. Children in the smile condition, but not in the no smile condition, remembered more about the happy character than the sad character in the story. These results extend mood congruity effects to 3- and 4-year olds, suggesting that at this age representations of emotion interact with basic memory processes. Moreover, the efficacy of reenactment of sensorimotor components of emotion in modifying mood is consistent with embodied representation of emotion during early childhood. PMID:26601787

  14. The relationship between self-report of depression and media usage

    Martin Block

    2014-09-01

    Full Text Available Depression is a debilitating condition that adversely affects many aspects of a person's life and general health. Earlier work has supported the idea that there may be a relationship between the use of certain media and depression. In this study, we tested if self-report of depression (SRD, which is not a clinically based diagnosis, was associated with increased internet, television, and social media usage by using data collected in the Media Behavior and Influence Study (MBIS database (N=19,776 subjects. We further assessed the relationship of demographic variables to this association. These analyses found that SRD rates were in the range of published rates of clinically diagnosed major depression. It found that those who tended to use more media also tended to be more depressed, and that segmentation of SRD subjects was weighted toward internet and television usage, which was not the case with non-SRD subjects, who were segmented along social media use. This study found that those who have suffered either economic or physical life setbacks are orders of magnitude more likely to be depressed, even without disproportionately high levels of media use. However, among those that have suffered major life setbacks, high media users – particularly television watchers – were even more likely to report experiencing depression, which suggests that these effects were not just due to individuals having more time for media consumption. These findings provide an example of how Big Data can be used for medical and mental health research, helping to elucidate issues not traditionally tested in the fields of psychiatry or experimental psychology.

  15. The relationship between self-report of depression and media usage.

    Block, Martin; Stern, Daniel B; Raman, Kalyan; Lee, Sang; Carey, Jim; Humphreys, Ashlee A; Mulhern, Frank; Calder, Bobby; Schultz, Don; Rudick, Charles N; Blood, Anne J; Breiter, Hans C

    2014-01-01

    Depression is a debilitating condition that adversely affects many aspects of a person's life and general health. Earlier work has supported the idea that there may be a relationship between the use of certain media and depression. In this study, we tested if self-report of depression (SRD), which is not a clinically based diagnosis, was associated with increased internet, television, and social media usage by using data collected in the Media Behavior and Influence Study (MBIS) database (N = 19,776 subjects). We further assessed the relationship of demographic variables to this association. These analyses found that SRD rates were in the range of published rates of clinically diagnosed major depression. It found that those who tended to use more media also tended to be more depressed, and that segmentation of SRD subjects was weighted toward internet and television usage, which was not the case with non-SRD subjects, who were segmented along social media use. This study found that those who have suffered either economic or physical life setbacks are orders of magnitude more likely to be depressed, even without disproportionately high levels of media use. However, among those that have suffered major life setbacks, high media users-particularly television watchers-were even more likely to report experiencing depression, which suggests that these effects were not just due to individuals having more time for media consumption. These findings provide an example of how Big Data can be used for medical and mental health research, helping to elucidate issues not traditionally tested in the fields of psychiatry or experimental psychology. PMID:25309388

  16. High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding

    Frokjaer, Vibe G; Vinberg, Maj; Erritzoe, David; Svarer, Claus; Baaré, William Frans Christian; Budtz-Joergensen, Esben; Madsen, Karine; Madsen, Jacob; Kessing, Lars V; Knudsen, Gitte Moos

    2009-01-01

    Mood disorders are elicited through a combination of genetic and environmental stress factors, and treatment with selective serotonin reuptake inhibitors ameliorates depressive symptoms. Changes in the serotonin transporter (SERT) binding may therefore occur in depressive patients and in subjects...... at risk for developing depression. The aim of this study was to explore whether abnormalities in SERT might be present in healthy individuals with familial predisposition to mood disorder. Nine individuals at high familial risk (mean age 32.2+/-4.2 years) and 11 individuals at low risk (mean age 32.......4+/-5.0 years) for developing mood disorder were included. The subjects were healthy twins with or without a co-twin history of mood disorder identified by linking information from the Danish Twin Register and the Danish Psychiatric Central Register. Regional in vivo brain serotonin transporter binding was...

  17. Basic concepts of depression

    Eugene S. Paykel

    2008-01-01

    This paper reviews concepts of depression, including history and classification. The original broad concept of melancholia included all forms of quiet insanity. The term depression began to appear in the nineteenth century as did the modern concept of affective disorders, with the core disturbance now viewed as one of mood. The 1930s saw the introduction of defined criteria into official diagnostic schemes. The modern separation into unipolar and bipolar disorder was introduced following empi...

  18. Mood alterations in mindful versus aerobic exercise modes.

    Netz, Yael; Lidor, Ronnie

    2003-09-01

    The results of most recent studies have generally indicated an improvement in mood after participation in aerobic exercise. However, only a few researchers have compared mindful modes of exercise with aerobic exercise to examine the effect of 1 single session of exercise on mood. In the present study, the authors assessed state anxiety, depressive mood, and subjective well-being prior to and following 1 class of 1 of 4 exercise modes: yoga, Feldenkrais (awareness through movement), aerobic dance, and swimming; a computer class served as a control. Participants were 147 female general curriculum and physical education teachers (mean age = 40.15, SD = 0.2) voluntarily enrolled in a 1-year enrichment program at a physical education college. Analyses of variance for repeated measures revealed mood improvement following Feldenkrais, swimming, and yoga but not following aerobic dance and computer lessons. Mindful low-exertion activities as well as aerobic activities enhanced mood in 1 single session of exercise. The authors suggest that more studies assessing the mood-enhancing benefits of mindful activities such as Feldenkrais and yoga are needed. PMID:14629072

  19. Mood changes by self-administered acupressure in Japanese college students: a randomized controlled trial.

    Horiuchi, Satoshi; Tsuda, Akira; Honda, Yasuhiro; Kobayashi, Hisanori; Naruse, Mayu; Tsuchiyagaito, Aki

    2015-01-01

    The aim of this 2-week study was to examine the effects of self-administered acupressure intervention onlevels of mood of 54 students (34 males and 20 females) majoring in acupuncture and moxibustion medicineat a college located in Fukuoka, Japan. Eligibility criteria were the ability to complete the intervention accurately and no history of psychiatric diseases. The students were randomly assigned to one of the two groups: an intervention group (IG, n = 28) and a control group (CG, n = 26). The IG participants completed fiveacupressure sessions three times a day (morning, noon, and night), involving the application of pressure to six acupuncture points (GB12, SI17, and LI18 according to 2008 World Health OrganizationRegional Office in the Western Pacific standard), three on the left and three on the right side of the neck for 5 s each. The CG participants were requested to spend their time as usual. Self-reported levels of tension-anxiety, depression-dejection, anger-hostility, vigor, fatigue, and confusion over the past week were measured before and after the study as the main outcomes. Side effects were not predicted and not assessed. The retention rate of this trial was 100%. Improvements in mood, defined as a change from baseline to 2 weeks later, were significantly greater in IG. Our results showed that self-administered intervention had the ability to alter mood levels in college students. PMID:25946916

  20. Event related field (ERF correlates of visual attentional processing during experimentally induced sad and happy mood states: an emotional rapid serial visual presentation (RSVP paradigm.

    Louisa Coulson

    2010-03-01

    Full Text Available Previous studies report emotion-related, mood-congruent information processing biases in patients with Major Depression. We examined whether rapidly presented emotional word stimuli influenced visual attentional processing; recruiting a sample of 24 psychiatrically healthy participants following induced neutral and sad (n=12 or happy (n=12 mood. Mood induction procedures (MIPs by means of self-referential statements and music were used to manipulate mood. We developed an emotional version of an RSVP paradigm wherein participants were instructed to identify a neutral yellow (T1 and neutral or emotional green (T2 word in a rapidly presented visual stream of distractor items (5 letter consonant strings. The attentional blink (AB, a phenomenon identified in RSVP paradigms, is the reduced ability to identify the second target word (T2 when participants are also required to identify the first target word (T1. We hypothesised that the AB would be associated with suppression of ERFs at 300-450ms (M3 component and 450-600ms (M4 component post-stimulus onset in left frontal and inferior parietal cortices. This effect would be reduced when T2 valence was congruent with the participants’ mood state, i.e. negative T2 following a sad MIP. Sad and happy MIPs altered mood state in the expected directions. A preliminary analysis of the behavioural data for the first 18 participants to complete the study following neutral and sad (n=8 or happy (n=10 MIPs was conducted. We found a main effect of duration (p<0.001 wherein a shorter latency between T1 and T2 presentation was associated with a larger proportion of T2 blinked trials. However the predicted interaction of mood*valence could not be found. A time-locked analysis of magnetoencephalography (MEG data for T2 blinked trials will be presented to investigate the predicted effects, and beamformer analysis will utilise MRI data to model the sources of the electrophysiological brain activity.

  1. Associations between Peer Victimization, Self-Reported Depression and Social Phobia among Adolescents: The Role of Comorbidity

    Ranta, Klaus; Kaltiala-Heino, Riittakerttu; Pelkonen, Mirjami; Marttunen, Mauri

    2009-01-01

    Associations of peer victimization with adolescent depression and social phobia (SP), while controlling for comorbidity between them, have not been sufficiently explored in earlier research. A total of 3156 Finnish adolescents aged 15-16 years participated in a survey study. Self-reported peer victimization, as well as self-reported depression…

  2. Family Report of ASD Concomitant with Depression or Anxiety among US Children

    McPheeters, Melissa L.; Davis, Alaina; Navarre, J. Richard; Scott, Theresa A.

    2011-01-01

    The objective is to estimate prevalence of parent-reported depression or anxiety among children with ASD, and describe parental concerns for their children. The design is Analysis of National Survey of Children's Health, 2003-2004. The participants are a national sample of 102,353 parents. 311,870 (544/100,000) parents of children ages 4-17 in the


  3. Psychometric Evaluation of a Self-Report Measure of Depression for Individuals with Mental Retardation

    Esbensen, Anna J.; Seltzer, Marsha Mailick; Greenberg, Jan S.; Benson, Betsey A.

    2005-01-01

    The psychometric properties of the Self-Report Depression Questionnaire (SRDQ) were evaluated, extending a previous assessment of this instrument. Data from two independent studies (Esbensen, 2004; Seltzer & Krauss, 1989) were pooled to generate a sample of 192 individuals with primarily mild or moderate mental retardation. Reliability estimates…

  4. Relationships between Exercise as a Mood Regulation Strategy and Trait Emotional Intelligence

    Andrew M. Lane

    2010-12-01

    Full Text Available Purpose:The aim of this study was to investigate the relationship between perception of emotional intelligence and beliefs in the extent to which exercising leads to mood-enhancement. Methods: Volunteer participants (N= 315 completed a 33-item self-report measure of trait emotional intelligence and an exercise-mood regulation scale.Results: Emotional intelligence significantly correlated with beliefs that exercise could be used to regulate mood (r =0.45, P<0 .01.Conclusion: Findings demonstrate that using exercise to regulate mood relates significantly to emotional intelligence and suggest that individuals who use exercise to enhance mood report higher scores of emotional intelligence.

  5. Social disability of Brazilian mood disorder patients

    A.M. Tucci

    2004-11-01

    Full Text Available Mood disorders cause many social problems, often involving family relationships. Few studies are available in the literature comparing patients with bipolar, unipolar, dysthymic, and double depressive disorders concerning these aspects. In the present study, demographic and disease data were collected using a specifically prepared questionnaire. Social adjustment was assessed using the Disability Adjustment Scale and family relationships were evaluated using the Global Assessment of Relational Functioning Scale. One hundred patients under treatment for at least 6 months were evaluated at the Psychiatric Outpatient Clinic of the Botucatu School of Medicine, UNESP. Most patients were women (82% more than 50 (49% years old with at least two years of follow-up, with little schooling (62% had less than 4 years, and of low socioeconomic level. Logistic regression analysis showed that a diagnosis of unipolar disorder (P = 0.003, OR = 0.075, CI = 0.014-0.403 and dysthymia (P = 0.001, OR = 0.040, CI = 0.006-0.275 as well as family relationships (P = 0.002, OR = 0.953, CI = 0914-0.992 played a significant role in social adjustment. Unipolar and dysthymic patients presented better social adjustment than bipolar and double depressive patients (P < 0.001, results that were not due to social class. These patients, treated at a teaching hospital, may represent the severest mood disorder cases. Evaluations were made knowing the diagnosis of the patients, which might also have influenced some of the results. Social disabilities among mood disorder patients are very frequent and intensive.

  6. Cross Cultural Relationships of Depression, Attachment Styles, and Quality of Romantic Relationships: Cultural Difference between Taiwanese

    Burleson, Yi-An Lo

    2013-01-01

    Relationship quality has been determined to be a positive factor in the treatment of depression (Brown, 2000; Fagan, 2009). Although the importance of marriage has been broadly studied, little research has investigated correlations among relationship quality, depressive moods, and attachment styles. Although the prevalence of depressive moods has


  7. DEPRESSION AND ITS PHARMACOLOGICAL MANAGEMENT: A CRITICAL REVIEW

    Nagapati P Bhat

    2015-07-01

    Full Text Available Depression is considered as an affective disorder characterized primarily by change of mood. It is associated with significant socioeconomic problems, morbidity and mortality. The prevalence of major depression in the general population is estimated at 5% in world population. Prevalence ranges from 9% in ambulatory medical patients to 30% in hospitalized patients. According to the World Health report approximately 450 million people suffer from a mental or behavioral disorder, yet only a small minority of them receives even the most basic treatment. Currently, the available anti-depressant agents are associated with unwanted side effects and have their own limitations. An increasing number of herbal products have been introduced into psychiatric practice, as alternative or complementary medicines. The added advantages of indigenous medicinal treatment would include its complementary nature to the conventional treatment making latter safer, well tolerated and economical remedy for depressive disorders

  8. Is Chronic Inflammation a Possible Cause of Obesity-Related Depression?

    Piotr Dąbrowski; Tomasz Wikarek; Wojciech Gruszka; ElĆŒbieta Semik-Grabarczyk; Joanna Janowska; Barbara Zahorska-Markiewicz; Piotr KoceƂak; Magdalena Olszanecka-Glinianowicz

    2009-01-01

    Adult obesity has been associated with depression, especially in women. Whether depression leads to obesity or obesity causes depression is unclear. Chronic inflammation is observed in obesity and depression. In 63 obese women without additional diseases depression level was assessed with the Beck's questionnaire. After evaluation of depression level study group was divided into groups according to the mood status (A—without depression, B—mild depression, and C—severe depression), and serum c...

  9. Mood-Dependent Cognitive Change in a Man with Bipolar Disorder Who Cycles Every 24 Hours

    Lam, Dominic; Mansell, Warren

    2008-01-01

    A case study of a bipolar patient whose mood changes every 24 hours is described to illustrate the changes in cognitive processing and content during different phases of bipolar disorder. The participant completed a battery of questionnaires and tasks on 4 separate occasions: twice when depressed and twice when manic. Depression tended to be


  10. Depression and Anxiety in Pain

    Woo, Adam KM

    2010-01-01

    Mood disorders, especially depression and anxiety, play an important role in the exacerbation of pain perception in all clinical settings.Depression commonly occurs as a result of chronic pain and needs treating to improve outcome measures and quality of life.Anxiety negatively affects thoughts and behaviours which hinders rehabilitation.Anxiety and depression in acute hospital settings also negatively affect pain experience and should be considered in both adults and children.Poor pain contr...

  11. TREATMENT OF DEPRESSION COLLABORATIVE RESEARCH PROGRAM (TDCRP)

    The NIMH Treatment of Depression Collaborative Research Program (TDCRP) was a collaborative agreement between NIMH (Mood, Anxiety and Personality Disorder Research Branch) and three research sites, George Washington University, University of Oklahoma and the University of Pittsbu...

  12. The effect of web based depression interventions on self reported help seeking: randomised controlled trial [ISRCTN77824516

    Mackinnon Andrew J; Barney Lisa; Leach Liana S; Christensen Helen; Griffiths Kathy M

    2006-01-01

    Abstract Background To date, there has been very little work investigating behaviour changes induced by interventions that are designed to increase help seeking. The present paper examines the effects of two Internet depression websites on help seeking. Methods 414 individuals with elevated scores on a depression assessment scale were randomly allocated to a depression information website, a cognitive-behavioural skills training website (CBT) or an attention control condition. Reports of help...

  13. Mechanisms of Resilience in Children of Mothers Who Self-Report with Depressive Symptoms in the First Postnatal Year

    Savage-McGlynn, Emily; Redshaw, Maggie; Heron, Jon; Stein, Alan; Quigley, Maria A.; Evans, Jonathan; Ramchandani, Paul; Gray, Ron

    2015-01-01

    Background Symptoms of maternal postnatal depression are associated with an increased risk of adverse effects on child development. However, some children exposed to postnatal depression have outcomes similar to unexposed children, and can be referred to as resilient. This study aimed to determine the mechanisms of resilience in children exposed to depressive symptoms postnatally. Method Data are from a prospective cohort study, the Avon Longitudinal Study of Parents and Children. Self-report...

  14. Recurrence of major depressive disorder following a switch from escitalopram to St. John’s Wort: a case report

    erhan ertekin

    2014-01-01

    Full Text Available Hypericum perforatum extracts, popularly known as St. John’s wort (known as “sar? kantaron” in Turkish are widely used for the treatment of major depression, especially in German speaking countries. Data on the effectiveness of such extracts for the maintenance treatment of major depression is limited. In this case report, a female patient who was euthymic under escitalopram treatment and experienced a recurrence of depression following a switch to St. John’s wort will be described.

  15. Does follow-up in a specialized center influence symptom profile and severity of bipolar depression?

    E. Timuçin Oral

    2010-01-01

    Full Text Available Introduction: Despite bipolar patients spend up to one third of their lives in depression, the treatment of bipolar depression remains as an understudied area. Although more atypical depressive symptoms are expected to be seen in bipolar depression, ethnocultural differences and regular follow-ups can change the onset and expression of clinical symptoms. Thus, in the present study, we aimed to evaluate the symptoms of depressive bipolar patients who are followed up in a specialized mood disorder unit. Methods: The most severe depressive symptoms of 144 bipolar patients were followed up using standardized forms in a specialized mood disorder outpatient unit. Obtained data analyzed by descriptive statistics. Results: It was determined that less than 10% of depressive symptoms were severe. Feelings of guilt and low self-esteem were not detected in nearly half of the patients (45,8%; active (3,5% or passive (15,3% suicidal ideation was seen approximately in one-fifth of the patients. The rate of psychotic symptoms was considerably low (4,2%. Beside this, vegetative symptoms other than loss of energy and lack of concentration were not seen in more than half of the patients. Adding a mood stabilizer or titrating the levels and psychotherapeutic interventions were adequate for remission in one-third of the patients. Discussion: Although previously it was reported bipolar depressive symptoms were severe with higher suicide rates, in less than 10% of patients, depressive symptoms were severe and the rate of active suicidal ideation was 3,5% in our study. Moreover, the rate of psychotic symptoms was found 4,2%. Although occurrence of milder symptoms contradicts with the literature, this can be explained by the follow-up of the patients in a specialized unit and early intervention before symptoms get more severe. Decreased need for pharmacological intervention can also be explained by the same reason.

  16. Ketamine-induced affective switch in a patient with treatment-resistant depression

    Girish Banwari

    2015-01-01

    Full Text Available There is growing evidence to support the rapid, albeit short-lived antidepressant effect of subanesthetic dose of ketamine, a noncompetitive glutamate N-methyl-D-aspartate receptor antagonist in treatment-resistant unipolar and bipolar depression. Ketamine is known to cause transient mood elevation or euphoria, psychotomimetic effects, and dissociative symptoms, but its use in unipolar or bipolar depression has not been reported to induce an affective switch amounting to persistent or prolonged hypomania/mania or manic-like syndrome. We report the case of a 52-year-old male with first episode, continuous, nonpsychotic, treatment-resistant, unipolar major depression of 10 years duration, who manifested a switch from depression to mania while being treated with subanesthetic dose of ketamine, given intramuscularly. This case suggests that polarity switch should be considered as a potential side effect while using ketamine for treatment-resistant depression.

  17. Ketamine-induced affective switch in a patient with treatment-resistant depression.

    Banwari, Girish; Desai, Prutha; Patidar, Prahlad

    2015-01-01

    There is growing evidence to support the rapid, albeit short-lived antidepressant effect of subanesthetic dose of ketamine, a noncompetitive glutamate N-methyl-D-aspartate receptor antagonist in treatment-resistant unipolar and bipolar depression. Ketamine is known to cause transient mood elevation or euphoria, psychotomimetic effects, and dissociative symptoms, but its use in unipolar or bipolar depression has not been reported to induce an affective switch amounting to persistent or prolonged hypomania/mania or manic-like syndrome. We report the case of a 52-year-old male with first episode, continuous, nonpsychotic, treatment-resistant, unipolar major depression of 10 years duration, who manifested a switch from depression to mania while being treated with subanesthetic dose of ketamine, given intramuscularly. This case suggests that polarity switch should be considered as a potential side effect while using ketamine for treatment-resistant depression. PMID:26288483

  18. Epigenetics in mood disorders

    McGowan, Patrick O; Kato, Tadafumi

    2007-01-01

    Depression develops as an interaction between stress and an individual’s vulnerability to stress. The effect of early life stress and a gene–environment interaction may play a role in the development of stress vulnerability as a risk factor for depression. The epigenetic regulation of the promoter of the glucocorticoid receptor gene has been suggested as a molecular basis of such stress vulnerability. It has also been suggested that antidepressive treatment, such as antidepressant medication ...

  19. Ecological Momentary Assessment of Mood Disorders and Mood Dysregulation

    Ebner-Priemer, Ulrich W.; Trull, Timothy J.

    2009-01-01

    In this review, we discuss ecological momentary assessment (EMA) studies on mood disorders and mood dysregulation, illustrating 6 major benefits of the EMA approach to clinical assessment: (a) Real-time assessments increase accuracy and minimize retrospective bias; (b) repeated assessments can reveal dynamic processes; (c) multimodal assessments


  20. Ecological Momentary Assessment of Mood Disorders and Mood Dysregulation

    Ebner-Priemer, Ulrich W.; Trull, Timothy J.

    2009-01-01

    In this review, we discuss ecological momentary assessment (EMA) studies on mood disorders and mood dysregulation, illustrating 6 major benefits of the EMA approach to clinical assessment: (a) Real-time assessments increase accuracy and minimize retrospective bias; (b) repeated assessments can reveal dynamic processes; (c) multimodal assessments…

  1. Personality Does not Influence Exercise-Induced Mood Enhancement Among Female Exercisers.

    Lane, Andrew M; Milton, Karen E; Terry, Peter C

    2005-09-01

    The present study investigated the influence of personality on exercise-induced mood changes. It was hypothesised that (a) exercise would be associated with significant mood enhancement across all personality types, (b) extroversion would be associated with positive mood and neuroticism with negative mood both pre- and post-exercise, and (c) personality measures would interact with exercise-induced mood changes. Participants were 90 female exercisers (M = 25.8 yr, SD = 9.0 yr) who completed the Eysenck Personality Inventory (EPI) once and the Brunel Mood Scale (BRUMS) before and after a 60-minute exercise session. Median splits were used to group participants into four personality types: stable introverts (n = 25), stable extroverts (n = 20), neurotic introverts (n = 26), and neurotic extroverts (n = 19). Repeated measures MANOVA showed significant mood enhancement following exercise across all personality types. Neuroticism was associated with negative mood scores pre- and post-exercise but the effect of extroversion on reported mood was relatively weak. There was no significant interaction effect between exercise-induced mood enhancement and personality. In conclusion, findings lend support to the notion that exercise is associated with improved mood. However, findings show that personality did not influence this effect, although neuroticism was associated with negative mood. Key PointsResearch in general psychology has found that stable personality trait are associated changes in mood states. Ninety females exercisers completed a personality test and mood scales before and after exercise. Results indicated mood changes were not associated with personality, although neuroticism was associated with negative mood. PMID:24453525

  2. The Sleep Or Mood Novel Adjunctive therapy (SOMNA) trial: a study protocol for a randomised controlled trial evaluating an internet-delivered cognitive behavioural therapy program for insomnia on outcomes of standard treatment for depression in men

    Cockayne, Nicole L.; Christensen, Helen M; Kathleen M. Griffiths; Naismith, Sharon L.; Hickie, Ian B; Thorndike, Frances P.; Ritterband, Lee M.; Glozier, Nick S

    2015-01-01

    Background Insomnia is a significant risk factor for depression onset, can result in more disabling depressive illness, and is a common residual symptom following treatment cessation that can increase the risk of relapse. Internet-based cognitive behavioural therapy for insomnia has demonstrated efficacy and acceptability to men who are less likely than women to seek help in standard care. We aim to evaluate whether internet delivered cognitive behavioural therapy for insomnia as an adjunct t...

  3. PERSONALITY DOES NOT INFLUENCE EXERCISE-INDUCED MOOD ENHANCEMENT AMONG FEMALE EXERCISERS

    Andrew M. Lane

    2005-09-01

    Full Text Available The present study investigated the influence of personality on exercise-induced mood changes. It was hypothesised that (a exercise would be associated with significant mood enhancement across all personality types, (b extroversion would be associated with positive mood and neuroticism with negative mood both pre- and post-exercise, and (c personality measures would interact with exercise-induced mood changes. Participants were 90 female exercisers (M = 25.8 yr, SD = 9.0 yr who completed the Eysenck Personality Inventory (EPI once and the Brunel Mood Scale (BRUMS before and after a 60-minute exercise session. Median splits were used to group participants into four personality types: stable introverts (n = 25, stable extroverts (n = 20, neurotic introverts (n = 26, and neurotic extroverts (n = 19. Repeated measures MANOVA showed significant mood enhancement following exercise across all personality types. Neuroticism was associated with negative mood scores pre- and post-exercise but the effect of extroversion on reported mood was relatively weak. There was no significant interaction effect between exercise-induced mood enhancement and personality. In conclusion, findings lend support to the notion that exercise is associated with improved mood. However, findings show that personality did not influence this effect, although neuroticism was associated with negative mood

  4. Treatment of Bipolar Depression

    KĂŒrƟat AltıntaƟ

    2005-01-01

    Full Text Available Depressive episodes are significant in bipolar illness since patients can spend up to one-third of their lives in depression. Although the treatment of bipolar depression remains an understudied area, new data from randomized, controlled trials and naturalistic studies expanded the range of treatments avaliable. The main aim in the treatment of bipolar depression is the prevention of the patient switching to mania and cycle acceleration, and antidepressant therapy may be contraindicated because of the risk for switching. Guidelines for the acute treatment of the bipolar depression emphasize treatment with a mood stabilizer, of which lithium has been the most thoroughly studied in randomized, controlled trials in acute bipolar depression. Lamotrigine had found significant ellicacy in recent studies as well and got FDA approval for its effect on preventing new episodes.

  5. Predicting depression using earliest childhood memories.

    Acklin, M W; Sauer, A; Alexander, G; Dugoni, B

    1989-01-01

    In order to investigate the utility of earliest childhood memories (EMs) in clinical assessment, this study investigated the value of EMs in predicting naturally occurring depressive mood states. Of interest were those features of EMs that discriminate depressed from nondepressed individuals. Subjects were 212 undergraduate volunteers who completed the Beck Depression Inventory, the Profile of Mood States, and a self-administered EM questionnaire. Utilizing thematic predictors derived from cognitive and psychodynamic theories of depression, depressed subjects were differentiated from nondepressed subjects at a rate significantly greater than chance, p less than .001, with a highly respectable estimate of cross-validation shrinkage. The findings demonstrate the phenomenon of mood dependent recall in autobiographical memory, namely, that memory attributes are strongly influenced by current mood state. Consistent with psychodynamic theories of depression and in contrast to cognitive theory, depressive mood states appear to facilitate retrieval of memory schemas involving deprivation and disturbing human interaction. Schemas involving loss of control, failure, or reactions to noncontingent reinforcement (perceptions of the self as agent) appear less salient than relationship schemas (perceptions of the self as related) in depressive experience. PMID:2918458

  6. Migraine with aura, bipolar depression, ACM aneurysm. A case report

    De Filippis, S.; Salvatori, E; Bozzao, A.; Fantozzi, L.M.; Martelletti, P

    2005-01-01

    B.D. is a 48–year–old professional woman. She has been suffering for migraine since she was 28, but she did not have serious problems until last year, when headache episodes became more frequent and it was necessary an admission to emergency room. At the beginning, the events were about 6 per month, lasting from 2 to 4 days, beating and of high intensity together with nausea, vomit, photo and phonophobia and visual area. Looking at the anamnesis, we report a psychiatric treatment since about ...

  7. Migraine with aura, bipolar depression, ACM aneurysm. A case report.

    de Filippis, Sergio; Salvatori, Emiliano; Bozzao, Alessandro; Fantozzi, Luigi Maria; Martelletti, Paolo

    2005-04-01

    B.D. is a 48-year-old professional woman. She has been suffering for migraine since she was 28, but she did not have serious problems until last year, when headache episodes became more frequent and it was necessary an admission to emergency room. At the beginning, the events were about 6 per month, lasting from 2 to 4 days, beating and of high intensity together with nausea, vomit, photo and phonophobia and visual area. Looking at the anamnesis, we report a psychiatric treatment since about ten years, because of type II bipolar disorder. In spite of the psychopharmacological treatment, as the patient came in our Regional Headache Center, she talked about 7 events with aura (scintillating scotomas, emianopsia) per month, lasting 2-4 days with photo and phonophobia, nausea, crying crisis, anxiety. Although the neurological examination was normal, the sudden aggravation of pain symptomatology and the unresposiveness to usual painkillers, suggested a cerebral CT and CT-angiography. CT and CT-angiography discovered the presence of an aneurysm of the right middle cerebral artery (MCA) of 4 mm diameter, with parietal irregularities. The patient was operated to reduce the hemorrhagic risk, with a positive result. One year after the operation, the patient reports a decrease of headache events with a frequency of 2 per month, lasting only a few hours, which she can now solve with COXIB. PMID:16362650

  8. Cyclic AMP response element binding protein and brain-derived neurotrophic factor: Molecules that modulate our mood?

    A Nair; V A Vaidya

    2006-09-01

    Depression is the major psychiatric ailment of our times, afflicting ∌20% of the population. Despite its prevalence, the pathophysiology of this complex disorder is not well understood. In addition, although antidepressants have been in existence for the past several decades, the mechanisms that underlie their therapeutic effects remain elusive. Building evidence implicates a role for the plasticity of specific neuro-circuitry in both the pathophysiology and treatment of depression. Damage to limbic regions is thought to contribute to the etiology of depression and antidepressants have been reported to reverse such damage and promote adaptive plasticity. The molecular pathways that contribute to the damage associated with depression and antidepressant-mediated plasticity are a major focus of scientific enquiry. The transcription factor cyclic AMP response element binding protein (CREB) and the neurotrophin brain-derived neurotrophic factor (BDNF) are targets of diverse classes of antidepressants and are known to be regulated in animal models and in patients suffering from depression. Given their role in neuronal plasticity, CREB and BDNF have emerged as molecules that may play an important role in modulating mood. The purpose of this review is to discuss the role of CREB and BDNF in depression and as targets/mediators of antidepressant action.

  9. Cyclic AMP response element binding protein and brain-derived neurotrophic factor: Molecules that modulate our mood?

    Nair, A; Vaidya, V A

    2008-01-01

    Depression is the major psychiatric ailment of our times, afflicting ~20% of the population. Despite its prevalence, the pathophysiology of this complex disorder is not well understood. In addition, although antidepressants have been in existence for the past several decades, the mechanisms that underlie their therapeutic effects remain elusive. Building evidence implicates a role for the plasticity of specific neuro-circuitry in both the pathophysiology and treatment of depression. Damage to limbic regions is thought to contribute to the etiology of depression and antidepressants have been reported to reverse such damage and promote adaptive plasticity. The molecular pathways that contribute to the damage associated with depression and antidepressant-mediated plasticity are a major focus of scientific enquiry. The transcription factor cyclic AMP response element binding protein (CREB) and the neurotrophin brain-derived neurotrophic factor (BDNF) are targets of diverse classes of antidepressants and are known to be regulated in animal models and in patients suffering from depression. Given their role in neuronal plasticity, CREB and BDNF have emerged as molecules that may play an important role in modulating mood. The purpose of this review is to discuss the role of CREB and BDNF in depression and as targets/mediators of antidepressant action. PMID:17006024

  10. Play Practices and Play Moods

    Karoff, Helle Skovbjerg

    2013-01-01

    The aim of this article is to develop a view of play as a relation between play practices and play moods based on an empirical study of children's everyday life and by using Bateson's term of ‘framing’ [(1955/2001). In Steps to an ecology of mind (pp. 75–80). Chicago: University of Chicago Press......], Schmidt's notion of ‘commonness’ [(2005). Om respekten. Kűbenhavn: Danmarks Pædagogiske Universitets Forlag; (2011). On respect. Copenhagen: Danish School of Education University Press] and Heidegger's term ‘mood’ [(1938/1996). Time and being. Cornwall: Wiley-Blackwell.]. Play mood is a state of being in...... which we are open and ready, both to others and their production of meaning and to new opportunities for producing meaning. This play mood is created when we engage with the world during play practices. The article points out four types of play moods – devotion, intensity, tension and euphorica – which...

  11. Subjective Memory Complaints are Involved in the Relationship between Mood and Mild Cognitive Impairment.

    Yates, Jennifer A; Clare, Linda; Woods, Robert T; Matthews, Fiona E

    2015-09-24

    Subjective memory complaints (SMC) are a criterion in many definitions of mild cognitive impairment (MCI). However, there is controversy over whether this is useful and appropriate, as previous research has suggested that SMC may be a function of mood problems such as anxiety and depression. This paper aimed to establish the relationship between MCI and mood in older people and to investigate the role that SMC play in the relationship. Structured interviews were conducted with community dwelling older people in Wales to collect information regarding cognitive functioning, mood, and well-being. A widely-used algorithm was used to categorize 3,173 participants into three groups: not cognitively impaired, MCI including SMC (MCI), and MCI without SMC (MCIW). The odds of experiencing anxiety or depression were calculated for each cognitive group. Participants with MCI had increased odds of experiencing symptoms of both anxiety and depression, but the odds were not changed for participants in the not cognitively impaired or MCIW categories. A mediation analysis was performed on the whole sample using cognition as a dichotomous variable, grouped using an age-, education-, and gender-adjusted median cut off point. This showed that SMC partially mediated the relationship between anxiety and cognition, and depression and cognition. Mood problems may be related to SMC rather than objective cognitive impairment, as only participants with MCI that included SMC showed increased odds of experiencing anxiety and depression. SMC are likely to play a mediating role in the relationship between mood and cognitive functioning. PMID:26402102

  12. Music-induced Mood Biases Decision Strategies during the Ultimatum Game

    Chung, Hwanjun; Lee, Eun Jung; Jung, You Jin; Kim, Sang Hee

    2016-01-01

    Recently, an increasing attempt has been made to understand the influence of mood on socioeconomic decision-making. We tested in this study whether an unpleasant mood would lead to unfavorable decisions more frequently than a pleasant mood, and whether decisions under different moods can be explained in different ways. Healthy volunteers were assigned to either a pleasant or unpleasant mood group and listened to musical excerpts to induce pleasant or unpleasant mood. Both groups completed the ultimatum game as a responder with an unacquainted partner who was actually a confederate. The proposer’s offers were made in six different ratios of split (1:9, 2:8, 3:7, 4:6, 5:5, 6:4) in a preprogramed manner unbeknownst to the participants. After the completion of the task as a responder, the participant rated subjectively perceived fairness and emotional feelings about each split of offer. The statistical results showed that the unpleasant mood group rejected unfair offers more often compared to the pleasant mood group. Self-reported ratings of perceived fairness and emotional feelings did not statistically differ between the two groups. Interestingly, however, only in the unpleasant mood group, rejection rates of unfair offers were negatively correlated with perceived fairness. Both the pleasant and unpleasant mood groups showed a negative correlation between rejection rates of unfair offers and self-reported happiness. These results suggest a possibility that different decision strategies operate under different mood during a socioeconomic exchange. PMID:27065921

  13. Sex Differences on Depression Self-Rating Scale in Two Populations: Research Report

    Seyed-Hossein, Salimi; Mohamad-Reza, Tagavi; Parviz, Azad-Fallah; Reza, Karaminia; Tayebi, A.

    The self-report of depressive symptoms of high school adolescents from two populations were compared. The study aims to find out whether or not; 1) there are significant sex differences between two communities and 2) with regard to the same-sex, there are significant differences between two communities. Nine hundred and twenty eight adolescents from London and 2012 adolescents from six cities from Iran were requested to fill in the Depression Self-Rating Scale (DSRS). The results showed that significant differences between two sexes in each population. All girls had higher mean scores on all items on DSRS than boys. With regard to the same-sex, significant differences were found between either female or male populations in two communities. The research showed that female adolescents from Iran were significantly experienced more depressive symptoms than the Londoners. Similar results were repeated for the male groups. In conclusion, female adolescents are vulnerable to life stressors and tend to experience more negative feedback and interpretations than boys. Moreover, social roles and limitations, particularly for Iranian adolescents, may influence female adolescents to demonstrate depression symptoms.

  14. Recognition of Depression and Anxiety among Elderly Colorectal Cancer Patients

    Cooper, Gregory S; Zhang, Amy Y.

    2010-01-01

    This study investigated the ICD-9 diagnostic rates of depressive and anxiety disorders, including major depression, neurotic depression, adjustment disorder with depressed mood, depressive disorder NOS (not elsewhere classified), and anxiety states, among elderly Medicare beneficiaries (age ≄ 65) who received a colorectal cancer diagnosis between 1998 and 2002 in U.S. The Seer-Medicare data, representing 14–25% of the U.S. population, was used to examine ICD-9 diagnostic rates of depressive a...

  15. Are consumers of Internet health information “cyberchondriacs”? Characteristics of 24,965 users of a depression screening site

    Leykin, Yan; Muñoz, Ricardo F.; Contreras, Omar

    2011-01-01

    Background The number of individuals looking for health information on the Internet continues to expand. The purpose of the study was to understand the prevalence of major depression, among English-speaking individuals worldwide looking for information on depression online. Methods An automated online Mood Screener website was created and advertised via Google AdWords, for one year. Participants (N = 24,965) completed a depression screening measure and received feedback based on their results. Participants were then invited to participate in a longitudinal mood screening study. Results Of the 24,965 who completed the screening, 66.6% screened positive for current major depression, 44.4% indicated current suicidality, and 7.8% reported a recent (past two weeks) suicide attempt. Of those consenting to participate in the longitudinal study (n = 1,327, from 86 countries), 77.4% screened positive for past depression, 64.6% reported past suicidality, and 17.5% a past suicide attempt. Yet, only 25% of those screening positive for current depression, and only 37.2% of those reporting a recent suicide attempt are in treatment. Conclusions Many of the consumers of Internet health information may genuinely need treatment and are not “cyberchondriacs”. Online screening, treatment, and prevention efforts may have the potential to serve many currently untreated clinically depressed and suicidal individuals. PMID:21681872

  16. Mood states influence cognitive control: the case of conflict adaptation.

    Schuch, Stefanie; Koch, Iring

    2015-09-01

    Conflict adaptation can be measured by the "congruency sequence effect", denoting the reduction of congruency effects after incongruent trials (where response conflict occurs) relative to congruent trials (without response conflict). Recently, it has been reported that conflict adaptation is larger in negative mood than in positive mood (van Steenbergen et al., Psychological Science 21:1629-1634, 2010). We conducted two experiments further investigating this important finding. Two different interference paradigms were applied to measure conflict adaptation: Experiment 1 was a Flanker task, Experiment 2 was a Stroop-like task. To get as pure a measure of conflict adaptation as possible, we minimized the influence of trial-to-trial priming effects by excluding all kinds of stimulus repetitions. Mood states were induced by presenting film clips with emotional content prior to the interference task. Three mood states were manipulated between subjects: amused, anxious, and sad. Across both interference paradigms, we consistently found conflict adaptation in negative, but not in positive mood. Taken together with van Steenbergen et al. (Psychological Science 21:1629-1634, 2010) findings, the results suggest that the negative-mood-triggered increase in conflict adaptation is a general phenomenon that occurs independently of the particular mood-induction procedure and interference paradigm involved. PMID:25100233

  17. The Relationships between Mood Disturbances and Pain, Hope, and Quality of Life in Hospitalized Cancer Patients with Pain on Regularly Scheduled Opioid Analgesic

    Utne, Inger; Miaskowski, Christine; Bjordal, Kristin; PAUL, STEVEN M; Rustűen, Tone

    2010-01-01

    Objective: The study purposes were to describe the percentage of patients in one of four mood groups (i.e., neither anxiety nor depression [NEITHER], only anxiety [ANX], only depression [DEP], both anxiety and depression [BOTH]) and to evaluate how differences in mood states are related to pain, hope, and quality of life (QOL). Methods: Oncology inpatients (n=225) completed Brief Pain Inventory, Herth Hope Index (HHI), and the European Organization for Research and Treatment of Cancer Core QO...

  18. Identifying Personality Pathology Associated With Major Depressive Episodes: Incremental Validity of Informant Reports

    Galione, Janine N.; OLTMANNS, THOMAS F.

    2013-01-01

    Major limitations are associated with the use of a single source of information to assess personality pathology. The construct validity of standardized interviews and informant reports on personality pathology has been established relative to other measures of personality pathology, but it is also important to consider these measures in relation to other constructs that should be related to personality pathology. One example is major depression. In this study, we evaluated whether less common...

  19. Applications of time-series analysis to mood fluctuations in bipolar disorder to promote treatment innovation: a case series.

    Holmes, E A; Bonsall, M B; Hales, S A; Mitchell, H; Renner, F; Blackwell, S E; Watson, P; Goodwin, G M; Di Simplicio, M

    2016-01-01

    Treatment innovation for bipolar disorder has been hampered by a lack of techniques to capture a hallmark symptom: ongoing mood instability. Mood swings persist during remission from acute mood episodes and impair daily functioning. The last significant treatment advance remains Lithium (in the 1970s), which aids only the minority of patients. There is no accepted way to establish proof of concept for a new mood-stabilizing treatment. We suggest that combining insights from mood measurement with applied mathematics may provide a step change: repeated daily mood measurement (depression) over a short time frame (1 month) can create individual bipolar mood instability profiles. A time-series approach allows comparison of mood instability pre- and post-treatment. We test a new imagery-focused cognitive therapy treatment approach (MAPP; Mood Action Psychology Programme) targeting a driver of mood instability, and apply these measurement methods in a non-concurrent multiple baseline design case series of 14 patients with bipolar disorder. Weekly mood monitoring and treatment target data improved for the whole sample combined. Time-series analyses of daily mood data, sampled remotely (mobile phone/Internet) for 28 days pre- and post-treatment, demonstrated improvements in individuals' mood stability for 11 of 14 patients. Thus the findings offer preliminary support for a new imagery-focused treatment approach. They also indicate a step in treatment innovation without the requirement for trials in illness episodes or relapse prevention. Importantly, daily measurement offers a description of mood instability at the individual patient level in a clinically meaningful time frame. This costly, chronic and disabling mental illness demands innovation in both treatment approaches (whether pharmacological or psychological) and measurement tool: this work indicates that daily measurements can be used to detect improvement in individual mood stability for treatment innovation (MAPP). PMID:26812041

  20. Depression and Hippocampal Neurogenesis: A Road to Remission?

    Eisch, Amelia J.; Petrik, David

    2012-01-01

    Adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new neurons to treat mood disorders such as depression. However, conflicting findings from preclinical research – involving stress, depression, and neurogenesis – highlight the complexity of considering neurogenesis as a “road to remission” from depression. To reconcile differences in the literature, we introduce the “neurogenic interactome”, a ...

  1. Metabolic disturbances connecting obesity and depression

    StephanieE.Fulton

    2013-01-01

    Obesity markedly increases the odds of developing depression. Depressed mood not only impairs motivation, quality of life and overall functioning but also increases the risks of obesity complications. Abdominal obesity is a better predictor of depression and anxiety risk than overall adipose mass. A growing amount of research suggests that metabolic abnormalities stemming from central obesity that lead to metabolic disease may also be responsible for the increased incidence of depression in o...

  2. Mood disorders and complementary and alternative medicine: a literature review

    Qureshi NA; Al-Bedah AM

    2013-01-01

    Naseem Akhtar Qureshi,1 Abdullah Mohammed Al-Bedah21General Administration for Research and Studies, Sulaimania Medical Complex, 2National Center for Complementary and Alternative Medicine, Ministry of Health, Riyadh, Saudi ArabiaAbstract: Mood disorders are a major public health problem and are associated with considerable burden of disease, suicides, physical comorbidities, high economic costs, and poor quality of life. Approximately 30%–40% of patients with major depression have only...

  3. Do mood disorders play a role in pig welfare?

    Giovanna Martelli; Lucio Tonello; Luca Sardi; Massimo Cocchi

    2010-01-01

    The work examines the hypothesis that the behavioural disorders found in pigs under conditions of stress may also be attributable to inherent conditions of alteration in mood. In light of new evidence that links the biochemical characterization of human depression to a particular profile of fatty acids in platelets, in particular the Palmitic Acid, Linoleic and Arachidonic, the decision was made to investigate platelet fatty acids of different animal species (pig, cattle, cat, sheep), togethe...

  4. The relationship between serotonin, decision-making and mood

    Faulkner, P

    2014-01-01

    The serotonin (5-HT) system has been implicated in both depression and reward and punishment processing. This thesis presents data from four studies designed to better understand the role of serotonin in decision-making and mood. Following the general introduction and description of the main experimental methods, the first experimental chapter presents a study that examined the relationship between naturally-varying 5-HT1A receptor availability, measured using positron emission tomography, an...

  5. Signs of Mood and Anxiety Disorders in Chimpanzees

    Ferdowsian, Hope R.; Durham, Debra L.; Kimwele, Charles; Kranendonk, Godelieve; Otali, Emily; Akugizibwe, Timothy; Mulcahy, J. B.; Ajarova, Lilly; Johnson, Cassie Meré

    2011-01-01

    Background In humans, traumatic experiences are sometimes followed by psychiatric disorders. In chimpanzees, studies have demonstrated an association between traumatic events and the emergence of behavioral disturbances resembling posttraumatic stress disorder (PTSD) and depression. We addressed the following central question: Do chimpanzees develop posttraumatic symptoms, in the form of abnormal behaviors, which cluster into syndromes similar to those described in human mood and anxiety diso...

  6. Effects of Music Therapy on Mood in Stroke Patients

    Kim, Dong Soo; Park, Yoon Ghil; Choi, Jung Hwa; Im, Sang-Hee; Jung, Kang Jae; Cha, Young A; Jung, Chul Oh; Yoon, Yeo Hoon

    2011-01-01

    Purpose To investigate the effects of music therapy on depressive mood and anxiety in post-stroke patients and evaluate satisfaction levels of patients and caregivers. Materials and Methods Eighteen post-stroke patients, within six months of onset and mini mental status examination score of over 20, participated in this study. Patients were divided into music and control groups. The experimental group participated in the music therapy program for four weeks. Psychological status was evaluated...

  7. Psychobehavioral validity of self-reported symptoms based on spontaneous physical activity.

    Jinhyuk Kim; Nakamura, Toru; Kikuchi, Hiroe; Yamamoto, Yoshiharu

    2015-08-01

    A limitation of self-reports is the presence of recall biases including retrospective distortions of the respondents' experiences. To overcome this concern, ecological momentary assessment (EMA) and day reconstruction method (DRM) have recently been developed. Very recently, we reported the psychobehavioral validity of within-individual temporal variations in momentary depressive mood recorded with EMA by examining co-variant properties with spontaneous physical activity as the external criteria. However, the validity of DRM in this context has not been objectively examined yet. Therefore, in this study, we examined the psychobehavioral validity of DRM by examining temporal associations with spontaneous physical activity and then showed the difference from EMA. Twenty-two healthy undergraduates wore a watch-type computer for two consecutive days and recorded self-reported symptoms (fatigue, depressive mood, and anxious mood) by EMA. They also recorded the symptoms afterward according to the series of behavioral episodes they reconstructed (DRM) about the same days. Physical activity was also obtained using an actigraph built into the watch-type computer. Multilevel analysis showed the significant association between depressive mood recorded with EMA and local statistics (mean activity levels calculated from 60min data length) of physical activity around EMA recordings. However, depressive mood recorded with DRM had no significant association with physical activity. As for fatigue and anxious mood, none of the methods showed significant associations with the local statistics of physical activity. These results imply that depressive mood recorded with EMA would include psychobehavioral information which cannot be captured with DRM. PMID:26737176

  8. Relationship between cognitive appraisals of symptoms and negative mood for subtypes of irritable bowel syndrome

    Nomura Shinobu

    2008-04-01

    Full Text Available Abstract Background The onset and course of irritable bowel syndrome (IBS are strongly influenced by psychological factors, and treatment often includes cognitive-behavioral therapy. We conducted a study of the relationships between cognitive appraisal of IBS symptoms and negative mood for the subtypes of IBS. Method The participants were 1087 college students who completed a set of questionnaires that included the Rome II Modular Questionnaire, Self-reported IBS Questionnaire, Cognitive Appraisal Rating Scale, and the Hospital Anxiety and Depression Scale. Results The participants included 206 individuals with IBS; 61 had diarrhea-predominant IBS (IBSD and 45 had constipation-predominant IBS (IBSC. The overall IBS group scored higher on anxiety and depression than the control group. The IBSD and IBSC groups each had significantly higher scores for anxiety but did not significantly differ from the control group in scores for depression. There were no significant differences between the IBSD and IBSC groups in their cognitive appraisal of IBS symptoms. For the IBSD group, anxiety was significantly, positively correlated with commitment, effect, and threat, and depression was significantly, negatively correlated with controllability. In contrast, there were no significant correlations between mood and cognitive appraisal for the IBSC group. Multiple regression analyses with abdominal symptoms as dependent variables and cognitive appraisals as independent variables showed that for the IBSD group, abdominal pain was significantly, positively correlated with commitment, and abdominal discomfort was significantly, positively correlated with appraisal of effect and threat. For the IBSC group, abdominal pain and hard stool were significantly, positively correlated with commitment, and abdominal discomfort was significantly, positively correlated with appraisal of effect and threat. Conclusion IBS patients as a general group report high levels of anxiety and depression. However, IBSD and IBSC were both associated only with high anxiety, but not depression, when compared to the non-IBS control group. For the IBSD group, anxiety was associated with cognitive appraisals, but this association was not found for the IBSC group. These groups did not differ in their associated cognitive appraisals, and are similar in terms of the positive relationship between abdominal pain and discomfort and the cognitive appraisals of coping.

  9. Use and perceived effectiveness of pre-competition mood regulation strategies among athletes

    Terry, PC; Dinsdale, SL; Karageorghis, CI; Lane, AM

    2006-01-01

    The well-established link between mood and sport performance highlights a need for athletes to develop mood regulation strategies. The present study investigated such strategies among 195 volunteer athletes. Participants completed the Regulation of Feelings Scale, a 37-item measure assessing frequency of use and perceived effectiveness of strategies to reduce feelings of anger, confusion, depression, fatigue, tension, and increase feelings of vigour on the day of a competition. The most popul...

  10. Stigma and Discrimination in People Suffering with a Mood Disorder: A Cross-Sectional Study

    R. Milev; Stuart, H.; Lazowski, L.; Koller, M

    2012-01-01

    Background. Much research is done on the stigma of mental illness, but little research has been done to characterize these phenomena from the perspective of people with mood disorders. Objective. To characterize the extent to which individuals with bipolar disorder and depression are stigmatized, determine factors related to higher levels of stigmatization, and assess the reliability of the Inventory of Stigmatizing Experiences in a population of people with a mood disorder. Methods. Two hund...

  11. Treatment for illegal drug use disorders: the role of comorbid mood and anxiety disorders.

    Melchior, Maria; Prokofyeva, Elena; YounĂšs, Nadia; Surkan, Pamela; Martins, Silvia

    2014-01-01

    BACKGROUND: Our aim was to examine whether comorbid mood and anxiety disorders influence patterns of treatment or the perceived unmet need for treatment among those not receiving treatment for illegal drug use disorders. METHODS: Data came from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, 2001-2002 and 2004-2005, n = 34,653). Lifetime DSM-IV illegal drug use disorder (abuse and dependence), as well as comorbid mood (major depression, dysthymia, manic disorder, ...

  12. Circadian Rhythms and Mood Disorders: Are the Phenomena and Mechanisms Causally Related?

    Bechtel, William

    2015-01-01

    This paper reviews some of the compelling evidence of disrupted circadian rhythms in individuals with mood disorders (major depressive disorder, seasonal affective disorder, and bipolar disorder) and that treatments such as bright light, designed to alter circadian rhythms, are effective in treating these disorders. Neurotransmitters in brain regions implicated in mood regulation exhibit circadian rhythms. A mouse model originally employed to identify a circadian gene has proven a potent mode...

  13. Loving-Kindness Meditation to Target Affect in Mood Disorders: A Proof-of-Concept Study.

    Hofmann, Stefan G; Petrocchi, Nicola; Steinberg, James; Lin, Muyu; Arimitsu, Kohki; Kind, Shelley; Mendes, Adriana; Stangier, Ulrich

    2015-01-01

    Conventional treatments for mood disorders primarily focus on reducing negative affect, but little on enhancing positive affect. Loving-kindness meditation (LKM) is a traditional meditation practice directly oriented toward enhancing unconditional and positive emotional states of kindness towards oneself and others. We report here two independent and uncontrolled studies carried out at different centers, one in Boston, USA (n = 10), and one in Frankfurt, Germany (n = 8), to examine the potential therapeutic utility of a brief LKM group intervention for symptoms of dysthymia and depression. Results at both centers suggest that LKM was associated with large-sized effects on self-reported symptoms of depression (d = 3.33 and 1.90), negative affect (d = 1.98 and 0.92), and positive affect (d = 1.63 and 0.94). Large effects were also found for clinician-reported changes in depression, rumination and specific positive emotions, and moderate effects for changes in adaptive emotion regulation strategies. The qualitative data analyses provide additional support for the potential clinical utility of the intervention. This proof-of-concept evaluation of LKM as a clinical strategy warrants further investigation. PMID:26136807

  14. Moods and the conservative process.

    Bollas, C

    1984-01-01

    In summary, then, moods are ordinary psychic phenomenon which serve important unconscious functions. Like the dream, a mood has a kind of necessary autistic structure to it: people who are in a mood, like persons who are asleep, are inside a special state where a temporal element is at play. They will emerge, like the dreamer, after the spell is over. Some moods, particularly those that are a part of a person's character, are occasions for the expression of a conservative object, as a conservative object is that internal self state that has been preserved intact during childhood often upon some breakdown between the child in relation to his parents. When a person goes 'into' a mood he becomes that child self who was refused expression in relation to his parents for one reason or another. As such, moods are often the existential registers of the moment of a breakdown between a child and his parents, and partly notate the parent's own developmental arrest, in that the parent was unable to deal appropriately with the child's particular maturational needs. What was a self experience in the child, one that could have been integrated into the child's continuing self development, was rejected by the parents, who failed to perform adequately as ordinary 'transformational objects', thereby destining a self state to be frozen by the child into a conservative object that fated such a state of being to be subsequently represented only through moods. PMID:6735602

  15. Measuring consistency of autobiographical memory recall in depression.

    Semkovska, Maria; Noone, Martha; Carton, Mary; McLoughlin, Declan M

    2012-05-15

    Autobiographical amnesia assessments in depression need to account for normal changes in consistency over time, contribution of mood and type of memories measured. We report herein validation studies of the Columbia Autobiographical Memory Interview - Short Form (CAMI-SF), exclusively used in depressed patients receiving electroconvulsive therapy (ECT) but without previous published report of normative data. The CAMI-SF was administered twice with a 6-month interval to 44 healthy volunteers to obtain normative data for retrieval consistency of its Semantic, Episodic-Extended and Episodic-Specific components and assess their reliability and validity. Healthy volunteers showed significant large decreases in retrieval consistency on all components. The Semantic and Episodic-Specific components demonstrated substantial construct validity. We then assessed CAMI-SF retrieval consistencies over a 2-month interval in 30 severely depressed patients never treated with ECT compared with healthy controls (n=19). On initial assessment, depressed patients produced less episodic-specific memories than controls. Both groups showed equivalent amounts of consistency loss over a 2-month interval on all components. At reassessment, only patients with persisting depressive symptoms were distinguishable from controls on episodic-specific memories retrieved. Research quantifying retrograde amnesia following ECT for depression needs to control for normal loss in consistency over time and contribution of persisting depressive symptoms. PMID:22397910

  16. Measuring consistency of autobiographical memory recall in depression.

    Semkovska, Maria

    2012-05-15

    Autobiographical amnesia assessments in depression need to account for normal changes in consistency over time, contribution of mood and type of memories measured. We report herein validation studies of the Columbia Autobiographical Memory Interview - Short Form (CAMI-SF), exclusively used in depressed patients receiving electroconvulsive therapy (ECT) but without previous published report of normative data. The CAMI-SF was administered twice with a 6-month interval to 44 healthy volunteers to obtain normative data for retrieval consistency of its Semantic, Episodic-Extended and Episodic-Specific components and assess their reliability and validity. Healthy volunteers showed significant large decreases in retrieval consistency on all components. The Semantic and Episodic-Specific components demonstrated substantial construct validity. We then assessed CAMI-SF retrieval consistencies over a 2-month interval in 30 severely depressed patients never treated with ECT compared with healthy controls (n=19). On initial assessment, depressed patients produced less episodic-specific memories than controls. Both groups showed equivalent amounts of consistency loss over a 2-month interval on all components. At reassessment, only patients with persisting depressive symptoms were distinguishable from controls on episodic-specific memories retrieved. Research quantifying retrograde amnesia following ECT for depression needs to control for normal loss in consistency over time and contribution of persisting depressive symptoms.

  17. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms.

    Cropley, Mark; Banks, Adrian P; Boyle, Julia

    2015-12-01

    This trial evaluated the impact of a Rhodiola rosea L. extract on self-reported anxiety, stress, cognition, and other mood symptoms. Eighty mildly anxious participants were randomized into two different groups of either Rhodiola rosea L (2?Ś?200 mg dose Vitanoź, 1 tablet taken before breakfast and 1tablet before lunch) or a control condition (no treatment). Self-report measures and cognitive tests were completed at four testing sessions over a period of 14 days. Relative to the controls, the experimental group demonstrated a significant reduction in self-reported, anxiety, stress, anger, confusion and depression at 14 days and a significant improvements in total mood. No relevant differences in cognitive performance between the groups were observed. Rhodiola rosea L (Vitanoź) presented a favourable safety tolerability profile. Although this was a non-placebo controlled trial, it is unlikely that the findings were the result of placebo effects as changes appeared gradual and were specific to certain psychological measures. However, we cannot determine a causal relationship; further investigations are recommended to support the effects of Rhodiola rosea L. extract on stress related symptoms. Copyright © 2015 John Wiley & Sons, Ltd. PMID:26502953

  18. Severe anorexia nervosa, co-occurring major depressive disorder and electroconvulsive therapy as maintenance treatment: a case report

    Poutanen, Outi; Huuhka, Kaija; Perko, Kaisa

    2009-01-01

    Introduction It is difficult to treat patients who, in addition to having severe anorexia nervosa, also have severe symptoms of major depressive disorder and a tendency for impulsive acting out behaviour. Our case report considers the feasibility of maintenance electroconvulsive therapy in such complicated cases. Case presentation This is a case report of a woman with anorexia nervosa and co-morbid severe major depressive disorder who was treated with electroconvulsive therapy as a maintenanc...

  19. Reduced reward anticipation in youth at high-risk for unipolar depression: A preliminary study

    Thomas M. Olino

    2014-04-01

    Full Text Available Offspring of depressed parents are at risk for depression and recent evidence suggests that reduced positive affect (PA may be a marker of risk. We investigated whether self-reports of PA and fMRI-measured striatal response to reward, a neural correlate of PA, are reduced in adolescent youth at high familial risk for depression (HR relative to youth at low familial risk for depression (LR. Functional magnetic resonance imaging assessments were conducted with 14 HR and 12 LR youth. All youth completed an ecological momentary assessment protocol to measure PA in natural settings and a self-report measure of depression symptomatology. Analyses found that HR youth demonstrated lower striatal response than LR youth during both reward anticipation and outcome. However, after controlling for youth self-reports of depression, HR youth demonstrated lower striatal response than LR youth only during reward anticipation. No significant differences were found between HR and LR youth on subjective ratings of PA or depressive symptoms. Results are consistent with previous findings that reduced reward response is a marker of risk for depression, particularly during reward anticipation, even in the absence of (or accounting for disrupted subjective mood. Further examinations of prospective associations between reward response and depression onset are needed.

  20. Effects of Self-Objectification on Self-Reported Eating Pathology and Depression.

    Register, Joshua D; Katrevich, Alina V; Aruguete, Mara S; Edman, Jeanne L

    2015-01-01

    Self-objectification occurs when people internalize an observer's perspective onto their own bodies. This study experimentally examined the impacts of self-objectification on 156 male and female college students. We induced a state of self-objectification by having undergraduate students in an experimental condition describe their bodies in writing, from an observer's viewpoint. Participants then completed a questionnaire measuring self-reported eating pathology and depression. When compared with a control group, the self-objectification manipulation caused an increase in self-reported eating pathology in both men and women. The results support previous research finding broad, negative impacts of self-objectification. PMID:26219177

  1. Mood and mental effort : informational mood impact on cardiovascular reactivity and the context-dependency of moods

    De Burgo De Lima Ramos, Joana

    2009-01-01

    This thesis goal was to test the role of mood in the mobilisation of mental effort. Based on the Mood-Behavior-Model, study 1 intended to clarify that mood effects on effort mobilization are context-dependent; study 2 was designed to provide a more conclusive test of mood informational impact on behavior-related judgments; and studies 3 and 4 manipulated judgment context itself, while accounting for the context-dependency of moods. Effort mobilization was operationalized as cardiovascular rea...

  2. The Effect of Mental Progression on Mood

    Mason, Malia F.; Bar, Moshe

    2012-01-01

    Mood affects the way people think. But can the way people think affect their mood? In the present investigation, we examined this promising link by testing whether mood is influenced by the presence or absence of associative progression by manipulating the scope of participants' information processing and measuring their subsequent mood. In…

  3. Managing Data in Help4Mood

    Maria K. Wolters

    2013-03-01

    Full Text Available Help4Mood is a system that supports the treatment of people with depression in the community. It collects rich cognitive, psychomotor, and motor data through a Personal Monitoring System and a Virtual Agent, which is then analysed by a Decision Support System; analysis results are fed back to patients and their treating clinicians. In this paper, we describe how the complex data is managed and discuss ethical issues. Data is stored in functional units that correspond to treatment relevant entities. Custom XML DTDs are defined for each unit, which are used to exchange information between system components. As far as possible, observations and findings are coded using SNOMED CT to ensure interoperability with other applications such as Electronic Health Records.

  4. Cognitive behaviour therapy (CBT) for anxiety and depression in adults with mild intellectual disabilities (ID): a pilot randomised controlled trial

    Blizard Robert; Parkes Charles; Martin Sue; Strydom Andre; Azam Kiran; Serfaty Marc; Hassiotis Angela; King Michael

    2011-01-01

    Abstract Background Several studies have showed that people with intellectual disabilities (ID) have suitable skills to undergo cognitive behavioural therapy (CBT). Case studies have reported successful use of cognitive behavioural therapy techniques (with adaptations) in people with ID. Modified cognitive behavioural therapy may be a feasible and effective approach for the treatment of depression, anxiety, and other mood disorders in ID. To date, two studies have reported group-based manauli...

  5. Depression associated with dementia.

    Gutzmann, H; Qazi, A

    2015-06-01

    Depression and cognitive disorders, including dementia and mild cognitive impairment, are common disorders in old age. Depression is frequent in dementia, causing distress, reducing the quality of life, exacerbating cognitive and functional impairment and increasing caregiver stress. Even mild levels of depression can significantly add to the functional impairment of dementia patients and the severity of psychopathological and neurological impairments increases with increasing severity of depression. Depressive symptoms may be both a risk factor for, as well as a prodrome of dementia. Major depressive syndrome of Alzheimer's disease may be among the most common mood disorders of older adults. Treating depression is therefore a key clinical priority to improve the quality of life both of people with dementia as well as their carergivers. Nonpharmacological approaches and watchful waiting should be attempted first in patients who present with mild to moderate depression and dementia. In cases of severe depression or depression not able to be managed through nonpharmacological means, antidepressant therapy should be considered. PMID:25962363

  6. Screening for depressed mood in an adolescent psychiatric context by brief self-assessment scales -- testing psychometric validity of WHO-5 and BDI-6 indices by latent trait analyses

    Blom, Eva Henje; Bech, Per; Högberg, Göran; Larsson, Jan Olov; Serlachius, Eva

    2012-01-01

    ABSTRACT: BACKGROUND: Major depressive disorder is prevalent in the adolescent psychiatric clinical setting and often comorbid with other primary psychiatric diagnoses such as ADHD or social anxiety disorder. Systematic manual-based diagnostic procedures are recommended to identify such comorbidity...... but they are time-consuming and often not fully implemented in clinical practice. Screening for depressive symptoms in the child psychiatric context using brief, user-friendly and easily managed self-assessment scales may be of clinical value and utility. The aim of the study is to test the...... 0.52 and for the BDI-6 of 0.46. Rasch analysis also accepted unidimensionality when testing males versus females (p > 0.05). CONCLUSIONS: The WHO-5 is psychometrically valid in an adolescent psychiatric context including both genders to assess the wellness dimension and applicable as a first step in...

  7. Dysphoric mood states are related to sensitivity to temporal changes in contingency

    Rachel M.Msetfi

    2012-09-01

    Full Text Available A controversial finding in the field of causal learning is that mood contributes to the accuracy of perceptions of uncorrelated relationships. When asked to report the degree of control between an action and its outcome, people with dysphoria or depression are claimed to be more realistic in reporting non-contingency (e.g., Alloy & Abramson, 1979. The strongest evidence for this depressive realism (DR effect is derived from data collected with experimental procedures in which the dependent variables are verbal or written ratings of contingency or cause, and, perhaps more importantly, the independent variable in these procedures may be ambiguous and difficult to define. In order to address these possible confounds, we used a two-response free-operant causal learning task in which the dependent measures were performance based. Participants were required to respond to maximise the occurrence of a temporally contiguous outcome that was programmed with different probabilities, which also varied temporally across two responses. Dysphoric participants were more sensitive to the changing outcome contingencies than controls even though they responded at a similar rate. During probe trials, in which the outcome was masked, their performance recovered more quickly than that of the control group. These data provide unexpected support for the depressive realism hypothesis suggesting that dysphoria is associated with heightened sensitivity to temporal shifts in contingency.

  8. Herbal remedies, mood, and cognition.

    Acee, Anna M; Sharoff, Leighsa

    2012-01-01

    Herbal medicines were the "sole" source of medicine for thousands of years, in every culture since the advent of human civilization. Today, patients are increasing the use of these botanicals for numerous conditions, such as mood and cognition. This article will explore commonly used herbal remedies for mood and cognition functioning. It is imperative that nurses and nurse practitioners obtain expertise with these botanicals with regard to efficacy, adverse effects and contraindications, possible drug interactions, and safety considerations. PMID:22157508

  9. Contribution of attachment insecurity to health-related quality of life in depressed patients

    Ponizovsky, Alexander M; Drannikov, Angela

    2013-01-01

    AIM: To examine the individual contributions of insecure attachment styles and depression symptom severity to health-related quality of life (HRQoL) in patients diagnosed with adjustment disorder (AJD) with depressed mood.

  10. Effects of frontal transcranial direct current stimulation on emotional processing and mood in healthy humans

    MichaelA.Nitsche

    2012-06-01

    Full Text Available The prefrontal cortex is involved in mood and emotional processing. In patients suffering from depression, the left dorsolateral prefrontal cortex is hypoactive, while activity of the right dorsolateral prefrontal cortex is enhanced. Counterbalancing these pathological excitability alterations by repetitive transcranial magnetic stimulation (rTMS or transcranial direct current stimulation (tDCS improves mood in these patients. In healthy subjects, however, rTMS of the same areas has no major effect, and the effects of tDCS are mixed. We aimed to evaluate the effects of prefrontal tDCS on mood and mood-related cognitive processing in healthy humans. In a first study, we administered excitability-enhancing anodal, excitability-diminishing cathodal and placebo tDCS to the left dorsolateral prefrontal cortex, combined with antagonistic stimulation of the right frontopolar cortex, and tested acute mood changes by an adjective checklist. Subjective mood was not influenced by tDCS. Emotional face identification, however, which was explored in a second experiment, was subtly improved by a tDCS-driven excitability modulation of the prefrontal cortex, markedly by anodal tDCS of the left dorsolateral prefrontal cortex for positive emotional content. We conclude that tDCS of the prefrontal cortex improves mood processing in healthy subjects, but does not influence subjective mood state.

  11. Negative Mood Increases Selective Attention to Negatively Valenced Body Parts in Female Adolescents with Anorexia Nervosa

    Svaldi, Jennifer; Bender, Caroline; Caffier, Detlef; Ivanova, Viliana; Mies, Nina; Fleischhaker, Christian; Tuschen-Caffier, Brunna

    2016-01-01

    Objective Previous research has yielded evidence of increased attentional processing of negatively valenced body parts in women with anorexia nervosa (AN), especially for those with high depressive symptomatology. The present study extended previous research by implementing an experimental mood manipulation. Method In a within-subjects design, female adolescents with AN (n = 12) and an age matched female control group (CG; n = 12) were given a negative and a positive mood induction at a one-week interval. After each mood induction, participants underwent a 3-min mirror exposure, while their eye movements were recorded. Results After the positive mood induction, both AN and CG participants displayed longer and more frequent gazes towards their self-defined most ugly relative to their self-defined most beautiful body part. However, after the negative mood induction, only females with AN were characterized by increased attention to their most ugly compared to their most beautiful body part, while CG participants’ attention distribution was balanced. Furthermore, in the negative (but not in the positive) mood induction condition gaze frequency and duration towards the most ugly body part was significantly stronger in the AN group relative to the CG. Discussion The results emphasize the role of negative mood in the maintenance of pathological information processing of the self-body. This increased body-related negativity-bias during negative mood may lead to the persistence and aggravation of AN patients’ body image disturbance. PMID:27123587

  12. The role of temperament in the relationship between morningness-eveningness and mood.

    Jankowski, Konrad S

    2014-02-01

    Apart from differences in circadian phase position, individuals with different morningness-eveningness levels vary in many more characteristics. Particularly consistent relationships have been observed between morningness-eveningness and mood. Eveningness has been associated with disadvantageous mood, e.g. depressiveness in healthy individuals, and mood disorders. A concept of social jetlag suggests that evening subjects function in less advantageous environments due to discrepancies between internal and social time (societies promote morning-oriented functioning), which results in their lowered mood. Individual temperament, as defined by the Regulative Theory of Temperament (RTT), refers to the capacity of the human organism to meet environmental requirements - the greater the capacity, the less negative impact of external conditions. Thus, the aim of this study is to determine which RTT traits are linked to both morningness-eveningness and mood dimensions and to test whether they account for the relationship between morningness-eveningness and mood. A sample of 386 university students (267 female) aged between 19 and 47 (M?=?21.15, SD?=?4.23) years completed the University of Wales Institute of Science and Technology (UWIST) Mood Adjective Check List, Morningness-Eveningness Questionnaire and Formal Characteristics of Behaviour - Temperament Inventory. Analyses revealed lower endurance (EN) and higher emotional reactivity (ER) related to eveningness as well as to lower hedonic tone (HT), energetic arousal (EA) and to higher tense arousal (TA). Moreover, eveningness was associated with lower HT, EA and higher TA. Among RTT traits, EN was most strongly related to eveningness, and mediation analyses revealed that this temperamental trait fully mediated the relationship between eveningness and the three mood dimensions. The remaining RTT traits did not provide more explanation of the association between morningness-eveningness and mood than EN itself. If subjects did not differ in EN, the association between morningness-eveningness and mood was absent. EN is discussed as a protective factor against negative consequences of social jetlag and particularly lowered mood in evening individuals. PMID:24144242

  13. Managing mood disorders in patients attending pulmonary rehabilitation clinics

    Selvarajah S

    2013-01-01

    Full Text Available Colleen Doyle,1–3 David Dunt,2 David Ames,1 Suganya Selvarajah11National Ageing Research Institute, Royal Melbourne Hospital Royal Park Campus, Parkville, Victoria, Australia; 2Centre for Health Policy, Programs and Economics, University of Melbourne, Parkville, Victoria, Australia; 3Australian Catholic University, Fitzroy, Victoria, AustraliaBackground: There is good evidence for the positive benefits of pulmonary rehabilitation (PR in the prevention of hospital admissions, lower mortality, and improved health-related quality of life. There is also increasing evidence about the impact of PR on mental health and, in particular, mood disorders. We aimed to identify how depression in chronic obstructive pulmonary disease (COPD patients in Victoria, Australia, is being managed in PR, to identify the prevalence of depressive symptoms among COPD patients who attend PR, and to determine whether patients with depressive symptoms or anxiety symptoms dropped out of PR early.Method: Of 61 PR clinics, 44 were invited and 22 agreed to participate. Telephone interviews were conducted to see how depression and anxiety in COPD patients were being recognized and managed in these clinics. A total of 294 questionnaires were distributed to patients by clinic coordinators to determine the prevalence of anxiety/depression, as measured by the Hospital Anxiety and Depression Scale. Coordinators were contacted to provide information on whether respondents dropped out of rehabilitation early or continued with their treatment at 2–4 months post program.Results: Seven clinics were not aware of local guidelines on assessment/treatment/management of mood. Four clinics did not use any screening tools or other aids in the recognition and management of depression and/or anxiety. Overall, eight clinics participating in this study requested advice on suitable screening tools. The patient survey indicated that the mean depression score on the Hospital Anxiety and Depression Scale was 5.0 (standard deviation 3.0, range 1–13. The mean anxiety score was 5.5 (standard deviation 3.4, range 0–18. There was no evidence of a link between failure to complete rehabilitation and depression or anxiety scores, as only three of 105 patients failed to complete their rehabilitation.Discussion: Awareness of management guidelines for depression and anxiety in COPD patients was variable across the clinics recruited into our study. We found no link between compliance with rehabilitation and depression, but our sample had limitations.Conclusion: Future research needs to investigate how best to encourage more use of available guidelines regarding integrating psychological and psychosocial support to supplement the exercise and education that are currently offered routinely by all PR clinics studied in Victoria, Australia.Keywords: chronic obstructive pulmonary disease, depression, anxiety, pulmonary rehabilitation

  14. Chronic inhalant dependence with early onset cognitive impairment, depression and psychotic disorders: a case report

    Safiye GĂŒrel

    2011-01-01

    Full Text Available Inhalant substance dependence is generally seen at 14-15 years of age and its prevalence decreases in adulthood. Inhalant use is common among disadvantaged groups, street children, people with history of crime, depression, suicide, antisocial attitudes, history of abuse, violence and any other drug dependence. Psychosocial factors are important in the beginning of inhalant dependence. Medical and neurological problems are frequently seen in chronic inhalant users. The duration of inhalant use is positively correlated with morbidity and mortality. In this report, medical and neuropsychiatric results of chronic inhalant dependence will be discussed. In our patient, chronic inhalant use caused central and peripheral neuropathy, cognitive impairment, depression, psychotic disorder, upper motor neuron type destruction in muscles and mild anemia. Neuropsychiatric destructive effects are prominent in chronic abuse. Mirtazapine and olanzapine treatment decreased depressive and psychotic symptoms, but cognitive impairment, neuropathy, upper motor neuron type destruction didn’t recover completely. Given serious and sometimes irreversible consequences of chronic inhalant dependence, early medical and psychosocial interventions seem very important.

  15. Eating Disorders and Major Depression: Role of Anger and Personality

    Giovanni, Abbate-Daga; Carla, Gramaglia; Enrica, Marzola; Federico, Amianto; Maria, Zuccolin; Secondo, Fassino

    2011-01-01

    This study aimed to evaluate comorbidity for MD in a large ED sample and both personality and anger as clinical characteristics of patients with ED and MD. We assessed 838 ED patients with psychiatric evaluations and psychometric questionnaires: Temperament and Character Inventory, Eating Disorder Inventory-2, Beck Depression Inventory, and State-Trait Anger Expression Inventory. 19.5% of ED patients were found to suffer from comorbid MD and 48.7% reported clinically significant depressive symptomatology: patients with Anorexia Binge-Purging and Bulimia Nervosa were more likely to be diagnosed with MD. Irritable mood was found in the 73% of patients with MD. High Harm Avoidance (HA) and low Self-Directedness (SD) predicted MD independently of severity of the ED symptomatology, several clinical variables, and ED diagnosis. Assessing both personality and depressive symptoms could be useful to provide effective treatments. Longitudinal studies are needed to investigate the pathogenetic role of HA and SD for ED and MD. PMID:21977317

  16. VNS and depression: current status and future directions.

    Walsh, Sally P; Kling, Mitchel A

    2004-09-01

    Vagus nerve stimulation (VNS) is an established anticonvulsant therapy in treatment-resistant patients with epilepsy. The known anatomical projections of the vagus nerve to many brain regions that have been implicated in mood disorders suggest that VNS may also have useful antidepressant effects. There has been growing interest in the potential application of VNS in the nonpharmacological management of treatment-resistant depression. Results from an open-label study, in which 59 subjects with treatment-resistant depression were treated for 10 weeks with VNS therapy, reported a 31% response rate. In a recent controlled double-blind trial of VNS and depression, short-term treatment for 10 weeks failed to demonstrate statistical improvement over sham treatment. Results from the long-term phase of this trial may be more significant, however published data are awaited. PMID:16293018

  17. Emotional eating as a mediator between depression and weight gain.

    van Strien, Tatjana; Konttinen, Hanna; Homberg, Judith R; Engels, Rutger C M E; Winkens, Laura H H

    2016-05-01

    Depression is often associated with weight gain but underlying mechanisms are unclear. This study assessed whether three psychological eating styles (emotional eating, external eating and restrained eating) act as mediators between depression and weight gain. We used structural equation modelling to test the hypothesized mediation models in a sample of 298 fathers and 294 mothers by assessing self-reported eating styles (Dutch Eating Behavior Questionnaire), depressive feelings (Depressive Mood List) and body mass index (BMI) at baseline and BMI after five years. In the model with emotional eating we also assessed the moderation effect of 5-HTTLPR genotype in a sub-sample of 520 Caucasians. All analyses were performed separately for the two sexes. Although the overall effect of depression on weight gain was statistically non-significant in both sexes, there was a causal chain between depression, emotional eating and weight gain in the mothers. Depressive symptoms were related to higher emotional eating and emotional eating predicted greater increases in BMI independently of depression. Moreover, the indirect effect (via emotional eating) of depression on BMI change was significant (Beta = 0.18, P = 0.026). This mediation effect was found to be independent of 5-HTTLPR genotype. No such mediation effect was found for the fathers. Further, external eating and restrained eating did not act as mediators between depression and weight gain in either sex. The finding that emotional eating acted as mediator between depression and weight gain in the mothers suggests that obesity interventions should take emotional eating into account. PMID:26911261

  18. The effect of music video clips on adolescent boys' body image, mood, and schema activation.

    Mulgrew, Kate E; Volcevski-Kostas, Diana; Rendell, Peter G

    2014-01-01

    There is limited research that has examined experimentally the effects of muscular images on adolescent boys' body image, with no research specifically examining the effects of music television. The aim of the current study was to examine the effects of viewing muscular and attractive singers in music video clips on early, mid, and late adolescent boys' body image, mood, and schema activation. Participants were 180 boys in grade 7 (mean age = 12.73 years), grade 9 (mean age = 14.40 years) or grade 11 (mean age = 16.15 years) who completed pre- and post-test measures of mood and body satisfaction after viewing music videos containing male singers of muscular or average appearance. They also completed measures of schema activation and social comparison after viewing the clips. The results showed that the boys who viewed the muscular clips reported poorer upper body satisfaction, lower appearance satisfaction, lower happiness, and more depressive feelings compared to boys who viewed the clips depicting singers of average appearance. There was no evidence of increased appearance schema activation but the boys who viewed the muscular clips did report higher levels of social comparison to the singers. The results suggest that music video clips are a powerful form of media in conveying information about the male ideal body shape and that negative effects are found in boys as young as 12 years. PMID:23443315

  19. Depression in children suffering from sickle cell anemia.

    Lukoo, Rita N; Ngiyulu, René M; Mananga, Gilbert L; Gini-Ehungu, Jean-Lambert; Ekulu, Pépé M; Tshibassu, Pierre M; Aloni, Michel N

    2015-01-01

    Sickle cell anemia is a chronic illness associated with important nonmedical complications. The prevalence of depression and its clinical profile among Congolese children suffering from sickle cell disease are unknown. We therefore conducted a cross-sectional study in children between 8 and 17 years. The main goal of this study was to describe prevalence and characteristics of depression in this population living in Kinshasa, the Democratic Republic of Congo. The cross-sectional survey is of patients attending 2 referral centers. Children aged 8 to 17 years old were evaluated by a semistructured interview and standardized scales for depression separated by age and sex, the Multiscore Depression Inventory for Children. Completed questionnaires were received from 81 respondents. There were 43 girls and 38 boys. Depression symptoms were observed in 70 (86.4%) cases. Among this group, 6 children (8.6%) were observed to have severe depression. The most common symptoms were observed to be social introversion (81.5%), defiance (77.8%), helplessness (76.5%), and sad mood (70.4%). Of the 70 subjects, 19 (23.5%) had suicidal ideation. In Kinshasa, the prevalence of depression was high to those reported in western countries. Psychological interventions for individuals with sickle cell disease might complement current medical treatment in our midst. PMID:25354254

  20. Rumination and behavioural factors in Parkinson's disease depression

    Julien, Camille L.; Rimes, Katharine A.; Brown, Richard G.

    2016-01-01

    Objective Parkinson's disease is associated with high rates of depression. There is growing interest in non-pharmacological management including psychological approaches such as Cognitive Behaviour Therapy. To date, little research has investigated whether processes that underpin cognitive models of depression, on which such treatment is based, apply in patients with Parkinson's disease. The study aimed to investigate the contribution of core psychological factors to the presence and degree of depressive symptoms. Methods 104 participants completed questionnaires measuring mood, motor disability and core psychological variables, including maladaptive assumptions, rumination, cognitive-behavioural avoidance, illness representations and cognitive-behavioural responses to symptoms. Results Regression analyses revealed that a small number of psychological factors accounted for the majority of depression variance, over and above that explained by overall disability. Participants reporting high levels of rumination, avoidance and symptom focusing experienced more severe depressive symptoms. In contrast, pervasive negative dysfunctional beliefs did not independently contribute to depression variance. Conclusion Specific cognitive (rumination and symptom focusing) and behavioural (avoidance) processes may be key psychological markers of depression in Parkinson's disease and therefore offer important targets for tailored psychological interventions. PMID:26944399

  1. Does treatment of subsyndromal depression improve depression and diabetes related outcomes: protocol for a randomised controlled comparison of psycho-education, physical exercise and treatment as usual

    Lovrenčić Marijana

    2011-01-01

    Full Text Available Abstract Background The prevalence of mood difficulties in persons with diabetes is approximately twice that in the general population, affecting the health outcomes and patients' quality of life in an undesirable way. Although subsyndromal depression is an important predictor of a more serious clinical depression, it is often overlooked. This study aims to compare the effects of two non-pharmacological interventions for subsyndromal depression, psychoeducation and physical exercise, with diabetes treatment as usual on mood- and diabetes-related outcomes. Methods and Design Type 2 diabetic patients aged 18-65 yrs. who report mood difficulties and the related need for help in a mail survey will be potential participants. After giving informed consent, they will be randomly assigned to one of the three groups (psychoeducation, physical activity, treatment as usual. Depressive symptoms, diabetes distress, health-related quality of life and diabetes self-care activities will be assessed at baseline, at 6 weeks, 6 months and 12 months. A structured clinical interview for DSM-IV Axis I Disorders (SCID-I will be performed at baseline and at one-year follow-up in order to determine the clinical significance of the patients' depressive symptoms. Disease-related data will be collected from patients' files and from additional physical examinations and laboratory tests. The two interventions will be comparable in terms of format (small group work, duration (six sessions and approach (interactive learning; supporting the participants' active roles. The group treated as usual will be informed about their screening results and about the importance of treating depression. They will be provided with brief re-education on diabetes and written self-help instructions to cope with mood difficulties. Primary outcomes will be depressive symptoms. Secondary outcomes will be glycaemic control, diabetes-related distress, self-management of diabetes and health-related quality of life. Tertiary outcomes will be biochemical markers reflecting common pathophysiological processes of insulin resistance, inflammation and oxidative damage that are assumed to be intertwined in both diabetes and depression. The mixed-effect linear model will be used to compare the outcome variables. Power analysis has indicated that the two intervention groups and the control group should comprise 59 patients to enable detection of clinically meaningful differences in depressive symptoms with a power of 80% and alpha = 0.05. Outcomes will be analysed on an intention-to-treat basis. Trial Registration ISRCTN: ISRCTN05673017

  2. Prevalence of mood disorders and utility of the PRIME-MD in patients undergoing radiation therapy

    Purpose: To validate a short, structured interview procedure that allows practicing oncologists to quickly and reliably identify mood disorders in their patients, and to estimate the prevalence and types of mood disorders in a radiation therapy patient setting, noting relationships between mood disorders and patient characteristics. Methods: Consecutive, eligible adult patients from the practices of two radiation oncologists were administered the Primary Care Evaluation of Mental Disorders (PRIME-MD) by the treating physician. A subset of these patients was also evaluated with the SCID, administered by trained mental health care personnel. Agreement between the two instruments was examined using the kappa statistic. Prevalence of mood disorders was determined from the PRIME-MD. The significance of relationships between patient characteristics and mood disorders was examined by chi-square and ANOVA analysis, and subsequently by multivariate logistic regression analysis. Results: One hundred twenty-two patients were studied. Fifty-three of these were administered the SCID. Agreement between the two instruments was very good (kappa = 0.70). A diagnosis of a depressive or anxiety disorder by the PRIME-MD was made in 59 of the 122 patients (48%, 95% confidence interval = 39%, 58%). Multivariate analysis showed that a diagnosis of a depressive mood disorder was significantly related to pain intensity and prior history of depression. Conclusion: We have demonstrated the validity and feasibility of the PRIME-MD administered by oncologists in making diagnoses of mood disorders. The prevalence of mood disorders in our set of patients undergoing a course of RT was nearly 50%. Future studies should describe the natural history of these disorders, and determine optimal intervention strategies

  3. Depressive Disorders: Treatments Bring New Hope.

    Sargent, Marilyn

    This booklet describes the symptoms, forms, causes, and treatment of depression, with particular focus on depression in children, adolescents, and older adults. Symptoms include: persistent sad or "empty" mood; feelings of hopelessness, guilt, or helplessness; loss of interest in ordinary activities; sleep disturbances; eating disturbances;


  4. Sintomas obsessivo-compulsivos na depressĂŁo pĂłs-parto: relatos de casos Obsessive-compulsive symptoms in postpartum depression: case reports

    Carla Fonseca Zambaldi

    2008-08-01

    Full Text Available A depressĂŁo pĂłs-parto Ă© o transtorno afetivo mais prevalente no puerpĂ©rio. O seu quadro clĂ­nico apresenta algumas peculiaridades sintomatolĂłgicas, podendo uma delas ser a presença mais freqĂŒente de obsessĂ”es e compulsĂ”es. Relatamos seis casos identificados pela anĂĄlise de prontuĂĄrios de puĂ©rperas atendidas no Programa de SaĂșde Mental da Mulher do Hospital das ClĂ­nicas da Universidade Federal de Pernambuco. Todas elas tinham diagnĂłstico de depressĂŁo atravĂ©s do Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I e apresentavam concomitantemente sintomas obsessivo-compulsivos. Nos relatos, abordamos o perĂ­odo de aparecimento desses sintomas nas mulheres deprimidas, assim como o seu conteĂșdo, duração e resposta ao tratamento. Em duas mulheres, os sintomas obsessivo-compulsivos precederam os depressivos, e em outras duas, deu-se o inverso. Houve exacerbação de obsessĂ”es e compulsĂ”es preexistentes em duas puĂ©rperas. O conteĂșdo mais freqĂŒente foi de pensamentos agressivos contra o bebĂȘ. Os sintomas tenderam a diminuir juntamente com a melhora da depressĂŁo.Postpartum depression is the most common affective disorder in the puerperium. There are some particular symptoms in its clinical presentation, and one might be the higher frequency of obsessions and compulsions. We report six cases identified from the analysis of medical charts of puerperal women receiving care at the Women's Mental Health Program, Hospital das ClĂ­nicas, Universidade Federal de Pernambuco, Brazil. All the women were diagnosed with postpartum depression using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I and had associated obsessive-compulsive symptoms. We report time of onset, topics, course and treatment response of these symptoms. Obsessive-compulsive symptoms preceded depressive symptoms in two women, and were succeeded in two other women. There was exacerbation of preexisting obsessions and compulsions in two puerperal women. The most frequent topic was aggressive thoughts toward the baby. Improvement in depressive symptoms tended to reduce obsessive-compulsive symptoms.

  5. Winter Fatigue and Winter Depression : Prevalence and Treatment with Bright Light

    Rastad, Cecilia

    2009-01-01

    The aim of this thesis is to study prevalence of winter depressive mood and treatment effects of bright light for persons with winter fatigue and winter depression. Study I is a cross-sectional survey of a random sample (N=1657) from the general population between 18-65 years of age in Dalarna, Sweden (latitude 60°N). Study II is a similar survey of 17-18 year old students (N=756) in the municipality of Falun. Approximately 20% of both samples report seasonal symptoms, mainly fatigue, lowered...

  6. Lifetime socio-economic position and depression

    Osler, Merete; Bruunsgaard, Helle; Mortensen, Erik Lykke

    2015-01-01

    BACKGROUND: Little is known about the influence of lifetime socio-economic position (SEP) on adult depression. We examined the association of SEP during the life course with depressive mood in late midlife and explored whether cognitive function at age 20, health-related behaviour and inflammatory...... among variables. RESULTS: Social circumstances during the life course were associated with depressive mood. Further, low lifetime SEP was associated with lower cognitive score, smoking, alcohol use, high body mass index (BMI) and increased level of high sensitive ProReactive Protein and Interleukin-6...

  7. Management of resistant depression.

    Warneke, L.

    1996-01-01

    Treatment-resistant depression is a relative concept. It has been formally defined as a mood disorder that fails to respond to three adequate trials of antidepressants. However, treatment resistance is relative to the expertise and knowledge of the treating physician and the availability of resources, such as electroconvulsive therapy. Only about 7% of patients show absolute treatment resistance, and even they can be helped.

  8. Somatic symptoms in depression

    Kapfhammer, Hans-Peter

    2006-01-01

    Both painful and nonpainful somatic symptoms essentially characterize clinical states of depressive mood. So far, this well-established psychopathological knowledge has been appreciated only insufficiently by the official diagnostic sys-terms of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Text Revision (DSM-IVTR) and the ICD-10 Classification of Mental and Behavioral Disorders. Clinical Descriptions and Diagnostic Guidelines (ICD-10). From a perspective of primary ...

  9. Depression in Coronary Artery Disease

    Nasser Safaie

    2012-09-01

    Full Text Available Introduction: Depression is one of the Common psychological disorders. From the cognitive point of view, the unhealthy attitudes increase the severity of the depression. The aim of this study was to investigate depression and unhealthy attitudes in coronary patients hospitalized at Tabriz Shahid Madani Heart Center. Methods: One hundred twenty eight hospitalized patients having myocardial Infarctions were studied regarding unhealthy attitudes, severity of depression and demographic data. Results: The study showed a significant relation between unhealthy attitudes, BDI (Beck Depression Inventory and severe depression. Moreover, a significant relation existed between gender and depression (P=0.0001. In addition, the level of education increased the intensity of unhealthy attitudes (P=0.0001. Several researches in both outside and inside Iran support the idea. Conclusion: Based on present study and more other investigations, it can be suggested to provide the necessary elements and parameters such as antidepressant medication, psychologists, complementary treatment for coping with negative mood and its unwanted consequences.

  10. Treatment resistant adolescent depression with upper airway resistance syndrome treated with rapid palatal expansion: a case report

    Miller Paul; Iyer Mala; Gold Avram R

    2012-01-01

    Abstract Introduction To the best of our knowledge, this is the first report of a case of treatment-resistant depression in which the patient was evaluated for sleep disordered breathing as the cause and in which rapid palatal expansion to permanently treat the sleep disordered breathing produced a prolonged symptom-free period off medication. Case presentation An 18-year-old Caucasian man presented to our sleep disorders center with chronic severe depression that was no longer responsive to ...

  11. Self-reported Health and Physician Diagnosed Illnesses in Women with Posttraumatic Stress Disorder and Major Depressive Disorder

    Calhoun, Patrick S.; Wiley, Matthew; Dennis, Michelle F.; Beckham, Jean C.

    2009-01-01

    PTSD has been associated with poor physical health. Depression is also associated with poor health, and may be responsible for the apparent relationship between PTSD and health outcomes. The current study examined self-reported and physician diagnosed medical morbidity in women. Women with PTSD alone were compared to three other groups of women: women with PTSD and comorbid major depressive disorder (MDD), women with MDD only, or women with neither diagnosis (comparison group). Results sugges...

  12. Retrospective reports of behavioral inhibition and young adults’ current symptoms of social anxiety, depression, and anxious arousal

    Schofield, Casey A.; Coles, Meredith E.; Gibb, Brandon E.

    2009-01-01

    The primary goal of this study was to investigate the specificity of the social versus nonsocial components of self-reported behavioral inhibition during childhood with young adults’ current symptoms of anhedonic depression, social anxiety, and anxious arousal. As hypothesized, the social component of BI demonstrated some specificity for symptoms of social anxiety versus other internalizing disorders. Furthermore, results support the hypothesis that the relationship between BI and depressive ...

  13. Multivitamin and Protein Supplement Use Is Associated With Positive Mood States and Health Behaviors in US Military and Coast Guard Personnel

    Austin, Krista G.; McGraw, Susan M.; Lieberman, Harris R

    2014-01-01

    Abstract Approximately 60% of Armed Forces personnel regularly consume dietary supplements (DSs). We investigated the association of mood and health behaviors with multiple classes of DSs in military and Coast Guard personnel (N = 5536). Participants completed a survey of DS use and the Quick Mood Scale to assess mood domains of wakeful-drowsiness, relaxed-anxious, cheerful-depressed, friendly-aggression, clearheaded-confused, and well coordinated–clumsy. Supplements were categorized as multi...

  14. Relationships between Exercise as a Mood Regulation Strategy and Trait Emotional Intelligence

    Lane, Andrew M.; Dharmendra Solanki

    2010-01-01

    Purpose:The aim of this study was to investigate the relationship between perception of emotional intelligence and beliefs in the extent to which exercising leads to mood-enhancement. Methods: Volunteer participants (N= 315) completed a 33-item self-report measure of trait emotional intelligence and an exercise-mood regulation scale.Results: Emotional intelligence significantly correlated with beliefs that exercise could be used to regulate mood (r =0.45, P

  15. Development and Validation of the Brief Music in Mood Regulation Scale (B-MMR)

    Saarikallio, Suvi

    2012-01-01

    mood regulation has been shown to be among of the most important reasons for musical engagement, but there has been a lack of a concise measurement instrument for this behavior. The current study focused on developing and testing the Brief Music in Mood Regulation scale (BMMR), a 21-item self-report instrument for assessing the use of seven different music-related mood-regulation strategies. Two survey studies (N = 1515 and N = 526) were conducted to first develop and ...

  16. Acute effects of beta blockade and exercise on mood and anxiety.

    Head, A.; Kendall, M. J.; FERNER, R; Eagles, C

    1996-01-01

    OBJECTIVE: To measure the previously reported beta blocker induced adverse changes in mood state and anxiety measures, and to determine if prolonged aerobic exercise attenuates such mood modifications. METHODS: After 4 days of drug treatment with comparable doses of propranolol (40 and 80 mg), metoprolol (50 and 100 mg), or placebo, mood (POMS) and anxiety states (STAI) were assessed in healthy volunteers, before and after 1 h of treadmill walking exercise at 50% maximum oxygen uptake. RESULT...

  17. Cognitive–Behavioral Treatment for Depression in Alcoholism

    Brown, Richard A.; Evans, D. Matthew; Miller, Ivan W.; Burgess, Ellen S.; Mueller, Timothy I.

    1997-01-01

    Alcoholics with depressive symptoms score ≄ 10 on the Beck Depression Inventory (A. T. Beck, C. H. Ward, M. Mendelson, J. Mock, & J. Erbaugh, 1961) received 8 individual sessions of cognitive–behavioral treatment for depression (CBT-D, n = 19) or a relaxation training control (RTC; n =16) plus standard alcohol treatment. CBT-D patients had greater reductions in somatic depressive symptoms and depressed and anxious mood than RTC patients during treatment. Patients receiving CBT-D had a greater...

  18. Depression-like behaviour in mice is associated with disrupted circadian rhythms in nucleus accumbens and periaqueductal grey.

    Landgraf, Dominic; Long, Jaimie E; Welsh, David K

    2016-05-01

    An association between circadian rhythms and mood regulation is well established, and disturbed circadian clocks are believed to contribute to the development of mood disorders, including major depressive disorder. The circadian system is coordinated by the suprachiasmatic nucleus (SCN), the master pacemaker in the hypothalamus that receives light input from the retina and synchronizes circadian oscillators in other brain regions and peripheral tissues. Lacking the tight neuronal network that couples single-cell oscillators in the SCN, circadian clocks outside the SCN may be less stable and more susceptible to disturbances, for example by clock gene mutations or uncontrollable stress. However, non-SCN circadian clocks have not been studied extensively in rodent models of mood disorders. In the present study, it was hypothesized that disturbances of local circadian clocks in mood-regulating brain areas are associated with depression-like behaviour in mice. Using the learned helplessness procedure, depression-like behaviour was evoked in mice bearing the PER2::LUC circadian reporter, and then circadian rhythms of PER2 expression were examined in brain slices from these mice using luminometry and bioluminescence imaging. It was found that helplessness is associated with absence of circadian rhythms in the nucleus accumbens and the periaqueductal grey, two of the most critical brain regions within the reward circuit. The current study provides evidence that susceptibility of mice to depression-like behaviour is associated with disturbed local circadian clocks in a subset of mood-regulating brain areas, but the direction of causality remains to be determined. PMID:26414405

  19. Mood and cognition after electrical injury: a follow-up study.

    Aase, Darrin M; Fink, Joseph W; Lee, Raphael C; Kelley, Kathleen M; Pliskin, Neil H

    2014-03-01

    Individuals who have experienced an electrical injury have been reported to demonstrate both acute and delayed cognitive and psychiatric symptoms. The present study assessed 20 electrically injured patients who underwent neuropsychological evaluations twice following their injury. Time since injury, time between assessments, and longitudinal mood changes were evaluated for their potential impact on simple and complex attention outcomes. As an overall group, there was little change over time from low average to average baseline attention/concentration performance. However, results indicated that longitudinal increases in depressive symptoms were consistently associated with poorer performance on a measure of simple and complex attention. Loss of consciousness, litigation status, baseline injury status (acute vs. post-acute), and time between evaluations were not significant predictors of changes in cognitive performance. Implications for the treatment of comorbid psychiatric issues and for future research on victims of electrical trauma are discussed. PMID:24395352

  20. Omega-3 polyunsaturated fatty acids and mood disorders

    Astorg Pierre

    2007-05-01

    Full Text Available The hypothesis of a role of n-3 polyunsaturated fatty acids (PUFA in the pathophysiology of depression has emerged from the observation that depressed patients had decreased levels of n-3 long-chain PUFA (especially eicosapentaenoic acid, EPA, and docosahexaenoic acid, DHA in plasma, erythrocytes, or adipose tissue, as compared to healthy controls, a decrease which was not observed with n-6 PUFA. Suicide attempters have much lower levels of EPA and DHA in red blood cells than hospital controls. Recently, a decreased level of DHA has also been observed in the post-mortem brain cortex of patients with major depression. The fact that these changes were specific of the n-3 family suggests that a low n-3 PUFA status or intake predisposes to depression. International ecological studies show a strong negative correlation between apparent fish consumption and the prevalence of depression or of bipolar disorder, as well as between DHA content of maternal milk and the prevalence of postpartum depression. In cross-sectional studies in several countries, a higher risk of depression or of depressive symptoms has been found in subjects with a lower fish consumption. In a French cohort of adults, habitual fatty fish consumption or a higher n-3 PUFA intake were associated with a lower risk of depression, especially of recurrent depression. Randomized, placebo-controlled trials have been conducted to test the effects of long-chain n-3 PUFA in depressive or bipolar patients. EPA as an adjunct to a standard treatment appears to improve depressive patients or bipolar patients in depressive phase when given at the dose of 1-2 g/day, and fish oil prevents depressive recurrences in bipolar patients. Recently, a mixture of EPA plus DHA has proven efficiency in untreated depressive children. In summary, many epidemiological and clinical works in the last ten years have abundantly documented the existence of an association between a low n-3 PUFA intake or status and a greater risk of mood disorder, as well as a therapeutic potential of n-3 PUFA in depressed or bipolar patients. Other works are necessary in order to establish a causal relation between n-3 PUFA deficiency and depression, and to further explore their preventive or therapeutic use.