UK PubMed Central (United Kingdom)

Invasive prenatal testing has become an important way to evaluate fetuses at increased risk for hereditary disorders. In utero sampling of fetal skin, liver, and muscle may be required to diagnose before-birth...Full Text Available

International Nuclear Information System (INIS)

In defining criteria for good protection against ionizing radiation, it is important to assess quantitatively the likely risk of any radiation exposure. The 'somatic' risks to the individual result mainly from induction of cancer in the organs irradiated, and these risks can now be estimated on the basis of numerous detailed epidemiological surveys of exposed human populations. Estimates of the risk of hereditary effects, from genetic changes induced in germ cells, are based largely on the frequency with which such effects are induced in other species. In both cases the risk at very low dose can be inferred using knowledge of the way in which radiation damage is caused in tissues. Coherent systems of radiation protection are based on a restriction of doses to the whole body and to individual organs, such that the induction of cancer and genetic harm is ...

International Nuclear Information System (INIS)

Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitaive are also the least relevant in terms of human carcinogenesis and human risk estimation. The development of cell culture systems has made it possible to assess at the cellular level the oncogenic potential of a variety of chemical, physical and viral agents. Cell culture systems afford the opportunity to identify factors and conditions that may prevent or enhance cellular transformation by radiation and chemicals. Permissive and protective factors in radiation-induced transformation include thyroid hormone and the tumor promoter TPA that increase the transformation incidence for a given dose of radiation, and retinoids, selenium, vitamin E, and 5-aminobenzamide that ...

International Nuclear Information System (INIS)

7,959 patients were examined by radionuclide in-vivo methods within one year, 1,228 of them by application of "1"3"1I-iodide (radioiodine test and scintigraphy of the thyroid gland). In compliance with the ICRP publications 26 and 27 the somatically effective equivalent dose H/sub s,eff/ was ascertained for several examining methods, derived from it the collective dose S/sub s,eff/ and considering a part of manifestation resulting from the age distribution of patients, the somatic risk regarding radiation-induced malignoma with fatal termination. For the patients examined by "1"3"1I-iodide the collective dose was 79.9 man x Sv and the mean somatic risk 30 x 10"-"5 with a part of manifestation of 0.39 accordig to 0.37 radiation-induced malignomas with fatal termination. For all patients examined by other radiopharmaceuticals the collective dose was 14.07 man x Sv, the mean somatic ...

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The Effective Dose Equivalent Concept defined by the International Commission on Radiological Protection in 1977 considers the risk from irradiation including both hereditary and somatic effects. This paper will deal with the definition of a concept for somatic effects only, the somatically significant dose equivalent. This is defined as the dose equivalent which if received by every member of the population, would be expected to produce the same total somatic injury to the population as does the actual dose equivalent received by various individuals. The somatically effective dose equivalent for a particular radiopharmaceutical is the weighted sum of the average dose equivalent to various organs. The dose equivalent to various organs can be derived from an extended MIRD formalism also considering the rest of body excluding the source volumes and the re iden e times in total body and the target organs. Examples are given for the calculation of ...

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Two local repair procedures, one without (9) and the other with (14) a bulbocavernosus muscle graft were performed on 20 patients with a radiation induced rectovaginal fistula. Four patients had two procedures successively. The initial success rate of both procedures was 7/9 and 14/14 respectively. Though the initial result of the bulbocavernosus graft was obviously better, in many of the local repair procedures, subclinical radiation damage progressed, resulting in recurrence of rectovaginal fistula (5), rectovesical fistula (4), pararectal abscess (2) etc. After a mean follow up of around 10 years, the success rate of fistula repair decreased to 5/9 and 13/14 and only 2/9 and 6/14 finally remained without a colostomy. A local repair operation should be restricted to carefully selected cases. The musculus gracilis is proposed as a better vascular graft. If the general condition of the patient does not allow more aggressive reconstructive ...

CERN Document Server

Differences in synchrotron radiation induced gas desorption from stainless steel and aluminium alloy

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Published in summary form only.

UK PubMed Central (United Kingdom)

Hereditary hemorrhagic telangiectasia is characterized by mucocutaneous and visceral telangiectasia and involves several organs with vascular malformations. It is an autosomal dominant disease and is...Full Text Available

International Nuclear Information System (INIS)

On 21 October 1994, three brothers entered a waste repository at Tammiku, Estonia, without authorization and removed a metal container enclosing a caesium-137 source. During the removal the source was dislodged and fell to the ground. One of the men picked up the source, placed it in his pocket and took it to his home in the nearby village of Kiisa. Very soon after entry into the repository he began to feel ill, and few hours later he began to vomit. The man was subsequently admitted to hospital with severe injuries to his leg and hip and died on 2 November 1994. The injury and subsequent death were not attributed to radiation exposure, and the source remained in the man's house with his wife and stepson and the boy's great-grandmother. The boy was hospitalized on 17 November with severe burns on his hands, and these were identified by a doctor as radiation induced. The authorities were alerted, and the Estonian Rescue Board recovered the ...

International Nuclear Information System (INIS)

The "1"3"1-radioiodine use in Guanabara area, during 1972-1973, is analysed. References are made to the radiation levels delivered to thyroid, bone marrow and gonads in a population of 27000 people examined by tracer techniques, 190 submitted to hyperthyroidism treatment and 50 treated for thyroid cancer. The pertinent literature gives some data concerning radiation induced cancer (leukaemia and thyroid cancer). By this, it was possible to estimate the probability of tumour occurrence in that population, assuming a linear relationship between dose and effect. The conclusions are the followings: 1 - there are many duties in this field at the present; 2 - the leukaemia incidence related to the 131-radioiodine use is negligible, either in diagnostic or therapeutic modalities; 3 - the possibility of thyroid tumors induced by radiation is real, specially in hyperthyroidism treatment; 4 - the use of tracer techniques that cause lower irradiation to ...

International Nuclear Information System (INIS)

Background: Some former retrospective studies have suggested that patients with Ewing's sarcoma might have a very high risk for developing secondary sarcomas if treated with radiotherapy. We have evaluated the risk of second malignancies (SM) in patients treated in the German Cooperative Ewing's Sarcoma Studies CESS 81 and CESS 86. Materials and methods: From January 1981 through June 1991, a total number of 674 patients was registered in the two multicentric Ewing's sarcoma trials CESS 81 (1981 through 1985) and CESS 86 (1986 through June 1991). The systemic treatment consisted in both studies of a four-drug-chemotherapy (VACA= vincristine, actinomycin D, cyclophosphamide and adriamycin; or VAIA= vincristine, actinomycin D, ifosfamide and adriamycin) and a total number of four courses, each lasting nine weeks, was recommended by the protocol. Local therapy was either complete surgery or surgery plus postoperative radiotherapy with 36-46Gy or ...

International Nuclear Information System (INIS)

The most important factor in assessing radiologic risk is ensuring scientific means for evaluation of the radioactive release impact upon humans and organisms. To evaluate quantitatively this impact not only knowledge of radioactivity distribution in these dynamical systems is necessary but also understanding the transfer mechanisms between ecosystem components is needed. Thus a complete radioecologic study appear to be very complex and needs defining the source term, dynamic description of radionuclides behavior in the ecosystem, estimation of radiation doses in the major components of the ecosystem and finally the effects of radiation doses upon different parts of the systems. A diagram of the steps implied in evaluation of the effects due to radioactive effluent release in the environment is presented and discussed. The following steps are described: - identification of radioactive sources, as well as their input rate. Presence of noxious materials such as heavy ...

UK PubMed Central (United Kingdom)

Haemophilia, the commonest hereditary bleeding disorder, arises because of the absence of, decrease in, or deficient functioning of plasma coagulation factor VIII or factor IX. With rare exceptions,...Full Text Available

UK PubMed Central (United Kingdom)

Though the genetic background of ischaemic and haemorrhagic stroke is often polygenetic or multifactorial, it can in some cases result from a monogenic disease, particularly in young adults. Besides...Full Text Available

UK PubMed Central (United Kingdom)

DNA double-strand breaks (DSBs) are generally accepted to be the most biologically significant lesion by which ionizing radiation causes cancer and hereditary disease. However, no information on the...Full Text Available

UK PubMed Central (United Kingdom)

Fast and efficient high-throughput techniques are essential for the molecular diagnosis of highly heterogeneous hereditary diseases, such as retinitis pigmentosa (RP). We had previously approached RP...Full Text Available

UK PubMed Central (United Kingdom)

To capitalize on the response of tumor cells to ionizing radiation, we developed a controlled-release nanoparticle drug delivery system using a targeting peptide that recognizes a radiation-induced...Full Text Available

UK PubMed Central (United Kingdom)

PurposeRadiation-induced heart disease (RIHD) is a severe side effect of thoracic radiotherapy. This study examined the effects of PTX and α-tocopherol on...Full Text Available

UK PubMed Central (United Kingdom)

By using EPR measurements of radiation-induced radicals it is possible to utilize human fingernails to estimate radiation dose after-the-fact. One of the potentially limiting factors in this...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Survival curves were constructed from dose-incidence curves for apoptosis in the crypts of mouse small intestine, using the number of apoptotic cells after high doses (N{sub M}) as maximum cell population size. The mean lethal doses (D{sub 0}) for the dose range 0-0.5 Gy were calculated for each time of day. A circadian rhythm in both D{sub 0} and N{sub M} values was detected, indicating that both the number and sensitivity of radiation-induced apoptosis were changing throughout the day. (author).

Energy Technology Data Exchange (ETDEWEB)

The resistance of six tropical hardwoods to fungal degradation by two wild-type strains of Phanerochaete chrysosporium Burdsall was investigated using vermiculite burial and wood-block weight loss techniques. Radiation-induced wood-polymer composites (WPC), based on two hardwoods Ramin and Rubberwood with methyl methacrylate, were prepared, and samples were also exposed to the wood-rotting fungus. A significant improvement in resistance to fungal decay was observed in the WPC. Scanning-electron micrographs of the two woods and their composites after fungal degradation are presented and discussed.

International Nuclear Information System (INIS)

Polytetrafluoroethylene was obtained by radiation induced polymerization of tetrafluoroethylene in acetone at 195 K. An average diameter of the products was very small compared with commercial one; it was about 0.3 micro-meters. The yield was reached to 100% with a dose of 4 kGy. The crystallinity of the products is decreasing with increasing dose. The products become amorphous, for higher irradiation doses. It was found that PTFE obtained by irradiation of TFE in acetone at 195 K has branching structure. This was demonstrated by means of "1"9F MAS NMR. (Author)

International Nuclear Information System (INIS)

The electronic structure of the clusters [V_3Si_4]"1"2"-, [Nb_3Sn_4]"1"2"-[Mo_3Ge_4]"1"5"- in crystalline V_3Si, Nb_3Sn, Mo_3Ge compounds is calculated by the Extended Hueckel method. The influence of different types of radiation induced defects on the density of states at the Fermi level (the anti-site defects, the displacement of atoms in linear chains, the vacancy-interstitial type defects) is considered. (author).

British Library Electronic Table of Contents (United Kingdom)

This study assessed the impact of the results of genetic testing for hereditary cancer from a multifactorial health psychology perspective, considering that emotional expression plays a key role in psychological adjustment. Measures of dispositional and transactional coping strategies, anxiety and alexithymia were filled out by 77 participants in a longitudinal study design. Statistical analyses were performed using general linear models and partial least squares path modelling, low-constraint methods that are particularly useful in the behavioural sciences. While anxiety levels prior to the result announcement were predictive of the distress experienced by noncarriers, considerable variability was observed for mutation carriers. Some subjects who had lower anxiety levels before the test d...

International Nuclear Information System (INIS)

There are very different views on the health hazards of DU munitions. Most of the concerns of veterans and their advisors focus on the radiological effects of DU and consequently these are the focus of this editorial. Effects on the kidney and environmental consequences are, however, considered in the second of the Royal Society reports and the main conclusions of both of the reports are outlined in the summary document published in this issue of the journal. The main radiological concerns focus on the irradiation of lung tissues from inhaled DU particles and irradiation resulting from the translocation of inhaled particles to the thoracic lymph nodes.The overwhelming scientific view, presented in the two Royal Society reports and in other independent reviews, is that the main risks of exposure to DU aerosols are an increase in lung cancer and (from chemical toxicity) damage to the kidney, although these are likely to be evident only following substantial intakes. ...

International Nuclear Information System (INIS)

Background: the fact that therapeutic irradiation can induce significant stenosis in the arteries of the head, neck, and chest, as welt as in the aorta and the iliac arteries, is familiar in daily practice and well documented in the literature. By contrast, radiation-induced renal artery stenosis seems to be a less widely known complication. Patients and methods: the sudden onset of medically refractory arterial hypertension and coma in a 27-year-old man is reported, who had been treated at age 20 with chemotherapy and radiotherapy for Ewing's sarcoma in the lumbar region. This treatment had been performed at the hospital of Sion, Switzerland in 2001. Also, the relevant literature from 1965 to 2007 is reviewed to underscore various aspects of this problem and to demonstrate the clinical relevance of renal artery stenosis as a potential long-term sequela of radiotherapy. Conclusion: radiation-induced renal artery stenosis has only rarely been ...

British Library Electronic Table of Contents (United Kingdom)

Radiofrequency electromagnetic fields (EMF) are harmful to public health, but the certain anti-irradiation mechanism is not clear yet. The present study was performed to investigate the possible protective effects of green tea polyphenols against electromagnetic radiation-induced injury in the cultured rat cortical neurons. In this study, green tea polyphenols were used in the cultured cortical neurons exposed to 1800?MHz EMFs by the mobile phone. We found that the mobile phone irradiation for 24?h induced marked neuronal cell death in the MTT (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl-tetrazolium bromide) and TUNEL (TdT mediated biotin-dUTP nicked-end labeling) assay, and protective effects of green tea polyphenols on the injured cortical neurons were demonstrated by testing the content ...

International Nuclear Information System (INIS)

The radiation induced reactions in LDPE in the presence of phenolic type antioxidants have been studied. It was shown that various antioxidants can influence the polyethylene network formation and the radical yield in different ways. The dependence of network structure on absorbed doses was determined by gel analysis, hot-set test and extraction of antioxidants for samples irradiated with accelerated electrons. It was found that the antioxidants eluted from polyethylene in higher percentage influence polymer crosslinking to a smaller degree. The ESR studies of #gamma#-irradiated blends of polyethylene with antioxidant indicate the presence of alkyl and phenoxyl radicals. The role of antioxidant molecules on radiation induced reactions in polyethylene-antioxidant systems is considered. The correlation between the network structure and the type of additive in polyethylene is also discussed. (author).

International Nuclear Information System (INIS)

Radicals formed in gamma-irradiated crystals of galactose and glycine were found, upon dissolution, to cause mutagenesis of Salmonella typhimurium strains TA-98 and TA-100. Although the reproducibility of the results has not been adequately determined, they suggest the possibility of developing a test to measure the mutagenic-carcinogenic potential of radiation-induced free radicals with a microbial system.

International Nuclear Information System (INIS)

The influence of additionally injected short-wavelength photobleaching light on the radiation hardness of Ge-doped graded index fibers working at 1,300 nm wavelength is investigated. Predictions are complicated by the fact that more efficient shortwave bleaching light experiences higher radiation-induced loss. Promising results are found for low fiber temperatures (approx-lt -50 C) and bleaching light of about 835 nm wavelength.

Energy Technology Data Exchange (ETDEWEB)

Plantago ovata Forsk - an economically important medicinal plant - was analyzed for trace elements and chlorophyll in a study of the effects of gamma radiation on physiological responses of the seedlings. Proton-induced X-ray emission (PIXE) technique was used to quantify trace elements in unirradiated and gamma-irradiated plants at the seedling stage. The experiments revealed radiation-induced changes in the trace element and chlorophyll concentrations.

International Nuclear Information System (INIS)

Phospholipid vesicles were found to be lysed by exposure to free radicals derived from irradiated glycine and galactose. The decomposition yield increased with vesicle concentration, and attained values of 0.0006 vesicles destroyed per radical added. Ionic charge at the phospholipid end groups was found to be more important than degree of unsaturation in determining this yield. Radicals derived from irradiated serine and alanine had no detectable lytic action at the vesicle concentrations tested.

International Nuclear Information System (INIS)

Tow experiments were carried out in 1981 and 1982 growth seasons at the greenhouse of the department of agriculture for soils and water researches, atomic energy authority, at inshas, to investigate the responses of two mutation derived lines of sesame and the local cultivar giza 25 to the application of micro nutrients. The possible effect of radiation on germination and growth of sesame seed was also studied in a separate experiment conducted in 1985 season, at inshas.

International Nuclear Information System (INIS)

Cell death after irradiation occurs by apoptosis in certain cell populations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in intestinal crypts) for neutrons with energies of 14 MeV and up to 600 MeV. It is thought that p53 plays a role in the phenomenon, as radiation-induced apoptosis is not observed in p53-null animals. (orig.).

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Factors influencing the rooting-potential of stem cuttings of conifers were studied for the purpose of improving methods of rapid vegetative propagation. Within the bounds of hereditary limits, root regeneration depends, to a considerable extent, on the qualities of rooting-media, date of cutting excision, age and physiological conditions of the stock plant, age of the cutting-wood, its position on the plant, and chemical treatment. Hardwood cuttings, which have a relatively high content of endogenous auxin and carbohydrates, and morphological root initials, gave the best results. This method made it possible to increase the growth rate of cuttings 2.5-5 times that of cuttings taken from shoots of current growth. (Refs. 21).

CERN Document Server

Security Risks of Peer-to-Peer Software across the Internet

Energy Technology Data Exchange (ETDEWEB)

Tensile specimens 60 ..mu..m thick of Ni-8 at. % Si have been bombarded at 475/sup 0/C to doses of 0.1 to 0.3 dpa with either 7 MeV proton or 28 MeV alpha particle beams. Deliberate embrittlement by high temperature (700/sup 0/C) preimplantation of helium was required to produce intergranular fracture. Depth profile sputtering and analysis in a Scanning Auger Microprobe was then used to study radiation-induced segregation of silicon both at the external surfaces and at internal interfaces. The external surfaces exhibited a strongly silicon-enriched zone for the first 10 to 20 nm followed by a broad (approx.200 nm), shallow silicon-depleted region. Segregation of silicon to grain boundaries varied from interface to interface and possibly from region to region on a given interface. In general, however, depth profiles of silicon content with distance from internal boundaries showed no noticeable depletion zone and a more gradual fall-off compared to the profiles from ...

Energy Technology Data Exchange (ETDEWEB)

Previous behavioral and pharmacological studies have implicated endorphins in radiation-induced locomotor hyperactivity of the C57BL/6J mouse. However, the endogenous opiate(s) responsible for this behavioral change have not been identified. The present study measured beta-endorphin-like immunoreactivity (beta-END-LI) in brain, blood, and combined brain and pituitary samples from irradiated and sham-irradiated C57BL/6J mice. After radiation exposure, levels of beta-END-LI decreased significantly in the brain. A similar, but not statistically significant, decline was measured in combined brain and pituitary samples. Concentrations of blood beta-END-LI were not changed by irradiation. These radiogenic changes in beta-END-LI are in some ways similar to those observed after other stresses. However, radiation-induced locomotor hyperactivity may be mediated more by alterations of beta-END-LI in the brain than in the periphery. Other endogenous opiate ...

Energy Technology Data Exchange (ETDEWEB)

This report concerns investigations in the title conducted by 8 groups of National Institute of Radiological Sciences (NIRS) during the period of 1998-2000. The groups are for investigation of: Effects of p53 tumor suppressor gene in radiation-induced leukemia, Role of atm-gene in dose rate effect of ionizing radiation, Function of DNA-dependent protein kinase catalytic subunit (DNA-PK{sub cs}), Functional complementation of radiation-sensitive mutant M10 cell line by human XRCC4 cDNA expression, Role of radiation-induced apoptosis in digital defects in embryonic mice, Functional analysis of S-phase specific novel nuclear protein NP95 by gene targeting, Role of chemokine in T cell development and lymphomagenesis, and establishment of production techniques of gene-modified mice using embryonic stem cells for genetic analysis of radiation-sensitive genes. The groups describe summaries of their studies and published original articles are also ...

International Nuclear Information System (INIS)

The thermal properties of five types of radiation-induced wood-polymer composites based on a tropical hardwood, rubberwood (Hevea braziliensis), was studied by oxygen index measurement, differential thermal analysis (DTA) and thermogravimetry (TG). The DTA and TG curves of composites were different from those of rubberwood, which can be attributed to the presence of the incorporated polymers. Of the five composites, the one impregnated with bis(2-chloroethyl)vinyl phosphonate reduced the initial temperature of decomposition, increased the peak temperatures of exothermic reactions, and increased the char yield. Comparison with physical blends of rubberwood and the corresponding polymer provided some evidence of chemical interaction of wood and polymer in some of the composites. (author).

Energy Technology Data Exchange (ETDEWEB)

In future experiments the readout electronics for pixel detectors is required to be resistant to a very high radiation level. In this paper we report on irradiation tests performed on several preFPIX2 prototype pixel readout chips for the BTeV experiment exposed to a 200 MeV proton beam. The prototype chips have been implemented in commercial 0.25 {micro}m CMOS processes following radiation tolerant design rules. The results show that this ASIC design tolerates a large total radiation dose, and that radiation induced Single Event Effects occur at a manageable level.

Energy Technology Data Exchange (ETDEWEB)

A wood/polymer composite was produced by impregnating Ramin wood with methyl methacrylate monomer and subsequently polymerizing it by gamma irradiation. To assess the improvement in compression strength of the wood caused by the polymer impregnation, a microbuckling compression failure mechanism was used to model the compression failure of the composite. Such a mechanism was found to predict a linear relationship between the compression strength and the percentage polymer impregnation (by weight). Uniaxial compression test results at 45({plus minus}5)% and 90({plus minus}5)% relative humidity levels, after being statistically analysed, showed that such a linear relationship was valid for up to 100% polymer impregnation. (author).

Energy Technology Data Exchange (ETDEWEB)

Wood-plastic composites (WPC) have been prepared with five low-grade woods, native to Syria, using three monomer systems; acrylamide, butylmethacrylate, and styrene, with methanol as the swelling solvent. Polymerization was induced at various radiation doses (10, 20, and 30 kGy) at a dose rate of 3.5 kGy/h using a {sup 60}Co gamma radiation source. Some physical properties of WPC, namely polymer loading and compression strength have been measured. The polymer loading decreases approximately with increasing density of the wood species used.

International Nuclear Information System (INIS)

Wood-plastic composites (WPC) have been prepared with five low-grade woods, native to Syria, using three monomer systems; acrylamide, butylmethacrylate, and styrene, with methanol as the swelling solvent. Polymerization was induced at various radiation doses (10, 20, and 30 kGy) at a dose rate of 3.5 kGy/h using a "6"0Co gamma radiation source. Some physical properties of WPC, namely polymer loading and compression strength have been measured. The polymer loading decreases approximately with increasing density of the wood species used. (author)

Wastenet

... Risk (Adverse) for Endangered Species: Risk to aquatic species if anticipated pesticide residue levels equal one-fifth of LD10 or one-tenth of LC50; risk to ...terrestrial species if anticipated pesticide residue levels equal one-fifth of LC10 or one-tenth of LC50. Risk Assessment: Qualitative and quantitative evaluation of the ... Risk for Non-Endangered Species: Risk to species if anticipated pesticide residue levels are equal to or greater than LC50. Risk Management: The process ...

International Nuclear Information System (INIS)

Radiation-induced enteritis is a well-recognized sequel of therapeutic irradiation. Therefore we examined the radioprotective properties of Punica granatum peel extract (PPE) on the oxidative damage in the ileum. Rats were exposed to a single whole-body X-ray irradiation of 800 cGy. Irradiated rats were pretreated orally with saline or PPE (50 mg/kg/day) for 10 days before irradiation and the following 10 days, while control rats received saline or PPE but no irradiation. Then plasma and ileum samples were obtained. Irradiation caused a decrease in glutathione and total antioxidant capacity, which was accompanied by increases in malondialdehyde levels, myeloperoxidase activity, collagen content of the tissue with a concomitant increase 8-hydroxy-2'-deoxyguanosine (an index of oxidative DNA damage). Similarly, pro-inflammatory cytokines (TNF-?, IL-1? and IL-6) and lactate dehydrogenase were elevated in irradiated groups as compared to control. PPE treatment reversed ...

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This paper explores for the first time the post-radiation-induced-graft polymerization on solid substrate using reversible addition-fragmentation transfer (RAFT) mechanism. Radiation-induced graft polymerization onto polymers is a potentially interesting technique to create easily new materials from highly resistant polymers, e.g. surface graft polymerization of acrylic acid (AA) onto poly(vinylidene difluoride) (PVDF) improves its surface properties without losing its excellent mechanical properties. As a consequence of the radical nature of the polymerization processes it is difficult to control molecular weight of grafted chains, and therefore design and standardize the properties of the final product. RAFT polymerization is a suitable method to obtain monodisperse polymers. The ability of the RAFT agents to control the polymer chain length could be an interesting approach to improve the grafted polymers obtained by ...

International Nuclear Information System (INIS)

Apoptosis, or programmed cell death (PCD), is a fundamental process that protects organismal integrity. In earlier work, we demonstrated that over-expression of either of two anti-apoptotic members of the BCL-2 family (BCL-2 or BCL-X L could elevate the frequency of radiation-induced mutations at the autosomal TK1 locus in human TK6 lymphoblasts that express wild-type TP53. Ectopic expression of BCL-X L also elevated the frequencies of double-strand break-induced gene conversion. The purpose of this study is to determine if BCL-2 family proteins promote radiation mutagenesis indirectly through their suppression of PCD, or whether the 'pro-mutagenic' function of these proteins can be separated from their anti-apoptotic function. We developed stable transfectants of TK6 cells that express a mutated form of BCL-X L with a single amino acid substitution in the BH1 domain that is known to interfere with the ability to suppress PCD (BCL-X L gly159ala). We also developed ...

International Nuclear Information System (INIS)

German translation of the publication 'The evaluation of risks from radiation' published in 1965 by the International Commission on Radiological Protection. In a survey, genetic and somatic risks from radiation are presented and explained. (HP).

British Library Electronic Table of Contents (United Kingdom)

The penetrance of Lebers hereditary optic neuropathy (LHON) in families with primary mitochondrial DNA (mtDNA) mutations is very complex. Matrilineal and nuclear genetic background, as well as environmental factors, have been reported to be involved in different affected pedigrees. Here we describe two large Chinese families that show a striking difference in the penetrance of LHON, in which 53.3% and 15.0% of members were affected (Pin vivo mitochondrial oxidative metabolism as described in a previous study. Evolutionary analysis failed to indicate any putatively pathogenic mutation that cosegregated with G11778A in these two pedigrees. Our results suggest that the variable penetrance of LHON in the two Chinese families is independent of both their mtDNA haplotype background and a seconda...

Energy Technology Data Exchange (ETDEWEB)

The information given in the present report about the Chernobyl accident and its radiological consequences indicates a serious crisis of the international radiation community. The following signs of this crises can be discerned: The international radiation community did not recognize the real reasons of the accident for a long time. It could not make a correct assessment of the damage to the thyroid of the affected populations of Belarus, Russia and the Ukraine. Up to present time it rejects the reliable data on hereditary malformations. It is not able to accept reliable data on the increase in the incidence in all categories of people affected by the Chernobyl accident. The international radiation community supported the Soviet authorities in their attempts to play down the radiological consequences of the Chernobyl accident for a long time. (author)

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The Business Value of IT

UK PubMed Central (United Kingdom)

A computer program, RISK-XLR, which calculates genetic risk for carrier status of a Mendelian X-linked recessive condition has been written for the Macintosh series of microcomputers. The program,...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The two main aspects of the concept proposed by the ICRP in recommendation 26 for the radiation risk, the differentiation of stochastic and non stochastic damages and the qualification of the stochastic risk, are discussed in its consequences for radiation protection in X-ray diagnostics. Quantitative results from the literature serve to demonstrate the risk factors for the various organs and their sum concerning the position of the layer. As special points of somatic risk appeared the mamma and the pelvic region. The particular risk of CT examination is determined by number and position of the layers and the scan parameters of the system. For typical CT examination the resulting risk factors are estimated in comparison with conventional X-ray diagnostics. The somatic risk of CT examination is relatively high and comparable to conventional ...

International Nuclear Information System (INIS)

The two main aspects of the concept proposed by the ICRP in recommendation 26 for the radiation risk, the differentiation of stochastic and non stochastic damages and the qualification of the stochastic risk, are discussed in its consequences for radiation protection in X-ray diagnostics. Quantitative results from the literature serve to demonstrate the risk factors for the various organs and their sum concerning the position of the layer. As special points of somatic risk appeared the mamma and the pelvic region. The particular risk of CT examination is determined by number and position of the layers and the scan parameters of the system. For typical CT examination the resulting risk factors are estimated in comparison with conventional X-ray diagnostics. The somatic risk of CT examination is relatively high and comparable to conventional ...

International Nuclear Information System (INIS)

Organizational risk indicators are proposed as a tool for risk control during operation of offshore installations, as a complement to QRA-based indicators. An organizational factor framework is developed based on a review of existing organizational factor frameworks, research on safety performance indicators, and previous work on QRA-based indicators. The results comprise a qualitative organizational model, proposed organizational risk indicators, and a quantification methodology for assessing the impact of the organization on risk. The risk indicators, when validated, will aid in a frequent control of the risk in the periods between the updating of the quantitative risk assessments.

International Nuclear Information System (INIS)

The Risk Evaluation System (RES) is an integrated approach to determining safeguards and security effectiveness and risk. RES combines the planning and technical analysis into a format that promotes an orderly development of protection strategies, planning assumptions, facility targets, vulnerability and risk determination, enhancement planning, and implementation. In addition, the RES computer database program enhances the capability of the analyst to perform a risk evaluation of the facility. The computer database is menu driven using data input screens and contains an algorithm for determining the probability of adversary defeat and risk. Also, base case and adjusted risk data records can be maintained and accessed easily.

Energy Technology Data Exchange (ETDEWEB)

Most plans for the disposition of surplus nuclear materials involve storage in sealed containers where the evolution of gases from reactions of adsorbed water could present both pressure and flammability hazards[l] . Despite efforts such as calcining the material to minimize the water content prior to packaging, both residual moisture and readsorbed water may be present in the final containers . Given the anticipated temperature excursions during transportation and storage, this water may thermally desorb, increasing the pressure, and/or thermally dissociate to produce H2 gas, increasing flammability hazards . In addition, the radiation from the nuclear material may induce radiolysis of the water with the likely products being water vapor, H2, 02 and H2O2. In order to better understand the relative importance of the thermal- and radiationinduced chemistry, we have studied the interactions of water on single crystals of uranium dioxide .

Energy Technology Data Exchange (ETDEWEB)

Elevation of zinc protoporphyrin (ZPP) levels in the blood has served as an indicator of lead poisoning and iron deficiency anemia for many years. We have discovered that sublethal doses of whole body irradiation with x-rays also elevates ZPP 2-3-fold over normal levels. The ZPP level does not begin to increase until days 12-14 postirradiation and peaks between days 18 and 20 before returning to normal levels between days 28 and 35. Increasing the radiation dose delays the onset of the rise in ZPP, but does not affect the magnitude of the elevation. At lethal doses, ZPP elevation is not observed. Neither of the two previously described mechanisms that cause elevations of ZPP, namely iron deficiency and inhibition of ferrochelatase, are responsible for the radiation-induced elevation of ZPP. The elevation of ZPP appears to be correlated with the recovery of the hematopoietic system from radiation injury.

International Nuclear Information System (INIS)

The synthetic process of polyethylene cation exchange capillary via radiation grafting polystyrene by simultaneous irradiation with "6"0Co #gamma#-ray source and sulfonation with concentrated H_2SO_4 was studied. The effects of dose, dose rate, monomer concentration, solvents, temperature and crosslinking agents on the graft copolymerization of styrene with polyethylene capillary were illustrated. The relationship between the radiation grafting conditions and the properties of ion-exchange capillary were examined. A polyethylene cation exchange capillary with I.D. 0.8 mm, length 20 m, exchange capacity 0.7 Meq/g 60% capacity in 10 s (flow rate 20 ml/min) was prepared. No significant loss of copacity was found from this ion-exchange capillary after 200 adsorption/regeneration cycles.

International Nuclear Information System (INIS)

We study CP-violating phenomena in the production, mixing and decay of a coupled system of CP-violating neutral Higgs bosons at #gamma##gamma# colliders, assuming a Minimal Supersymmetric Standard Model (MSSM) Higgs sector in which CP violation is radiatively induced by phases in the soft supersymmetry-breaking gaugino masses and third-generation trilinear squark couplings. We discuss CP asymmetries in the production and decays of #mu#"+#mu#"-, #tau#"+#tau#"-, b-bar b and t-bar t pairs. We find large asymmetries when two (or all three) neutral Higgs bosons are nearly degenerate with mass differences comparable to their decay widths, as happens naturally in the CP-violating MSSM for values of tan#beta#-bar 5 (30) and large (small) charged Higgs-boson masses.

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Two patients who developed large intracranial vessel occlusion after standard radiation therapy for brain tumor are described. This form of vascular occlusion is usually seen in patients who have previously been treated by radiotherapy for intracranial tumor who then develop a relatively acute change in neurologic status. Histology of the lesion mimics accelerated focal arteriosclerosis. The clinical and radiographic manifestations of one case were highly atypical. The vasculopathy became evident shortly after termination of radiation therapy for a fourth ventricular ependymoma, and the angiographic picture stimulated a diffuse arteritis. The second patient was more typical, with clinical symptoms developing 12 years after radiation therapy for an oligodendroglioma. Occlusion of a proximal vessel that had been included in the radiation port was demonstrated radiographically and confirmed by pathologic examination. The clinical, angiographic, and histologic features of these two cases ...

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Photoluminescence spectroscopy measurements were carried out for silicon 50{mu}m BSFR space solar cells irradiated with 1MeV electrons with a fluence exceeding 1 x 10{sup 16} e/cm{sup 2} and 10MeV protons with a fluence exceeding 1 x 10{sup 13} p/cm{sup 2}. The results were compared with the previous result performed in a relative low fluence region, and the radiation-induced defects which cause anomalous degradation of the cell performance in such large fluence regions were discussed. As far as we know, this is the first report which presents the PL measurement results at 4.2K of the large fluence radiation irradiated silicon solar cells. (author)

International Nuclear Information System (INIS)

Nickel ion radiation at 500 C was shown to have a strong effect on the surface electrochemistry and intergranular corrosion (IGC) of stainless steel (SS). Measured current densities in a 1 N sulfuric acid solution at room temperature were increased at active-passive, passive, and transpassive potentials. Radiation effects on the current decay behavior and susecptibility to IGC were similar for a fine-grained (FG) S alloy and for a very large-grained (LG) SS. Radiation-induced segregation (RIS) at the surface was believed to promote higher currents at short times, whereas segregation at grain boundaries was responsible for IG attack. Analytical electron microscopy (AEM) measurements revealed chromium and iron depletion plus Ni and silicon enrichment at grain boundaries in irradiated specimens. Si enhanced dissolution at transpassive potentials, whereas Cr depletion did the same at active-passive and passive potentials.

International Nuclear Information System (INIS)

Increased levels of epidermal growth factor receptor have been reported in a variety of tumors, including pulmonary squamous cell carcinomas in man. The purpose of this study was to determine if increased levels of epidermal growth factor (EGFR) were present in lung tumors from Beagle dogs that had been exposed to "2"3"9PuO_2- Using immunohistochemical techniques, sections from 17 lung tumors were examined for the presence of EGFR. Seven of the tumors were strongly positive for EGFR; the remainder of the tumors and the normal lung sections were negative. The positive immunostaining could not be correlated with the histologic phenotype of the tumors. Work is in progress to determine the level of EGFR in preneoplastic, proliferative epithelial foci in the Iung. (author)

International Nuclear Information System (INIS)

The effect of exposure to gamma rays on LPO contents in liver, spleen and kidney of mice and the anti-lipid-peroxidation of preparations of chinonin, tannic acid and squalene were reported. All these preparations were given by intragastric perfusion. For LPO, a modified method of TBA spectrophotometry was used for determination. The results show that LPO contents in tissues increased 72 h after whole-body exposure of mice to gamma rays, that in range of 0-4 Gy, there was a linear relationship between radiation doses and LPO contents, and that all three preparations were effective in reduction of the LPO content in liver, spleen and kidney of mice, with chinonin (at dose of 0.35 mg/mouse#centre dot#day) being more effective than tannic acid (at dose of 15 mg/mouse#centre dot#day) and squalene (at dose of 0.6 mg/mouse#centre dot#day).

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Data are presented to support the hypothesis that the initial step in the morphologic transformation of irradiated rodent (BALB/3T3) cells is a frequent cellular event involving a large fraction of the irradiated population. This process appears to involve DNA damage, but not to represent a targeted mutation in specific structural gene(s). Morphologic transformation and immortalization appear to be distinct steps in the overall process of transformation. In contradistinction to rodent cells, immortalization is a very rare event in human diploid cells which is induced at extremely low frequencies. The hypothesis is presented that immortality develops among clones of cells bearing stable chromosomal rearrangements which emerge during the proliferation of a population of radiation damaged cells.

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The content and biosynthesis of glycosaminoglycans (GAGs) were studied in pig thigh muscle after acute local {gamma}-irradiation. Seven months following irradiation, the muscular tissue next to the irradiation cone was replaced by severe mutilating fibrosis delimited by an intermediary perifibrotic zone. Results showed a parallel increase of collagen and GAG content in perifibrotic and fibrotic tissues. Sulphated GAGs, heparan sulphate and dermatan sulphate were preferentially accumulated in fibrotic tissue, while the hyaluronic acid content increased only slightly. Synthesis of sulphated GAGs was more elevated in fibrotic tissue than in perifibrotic zone as compared with normal muscle. Seven months after irradiation well-developed fibrotic tissue continued to synthesize and to accumulate extracellular matrix macromolecules. (Author).

British Library Electronic Table of Contents (United Kingdom)

The relative risk model (RRM) was applied in regional ecological risk assessments successfully. In this study, the RRM was developed through increasing the data of risk source and introducing the source?stressor?habitat exposure filter (SSH), the endpoint?habitat exposure filter (EH) and the stressor?endpoint effect filter (SE) to reflect the meaning of exposure and effect more explicit. Water environment which include water quality, water quantity and aquatic ecosystems was selected as the ecological risk assessment endpoints. The Luanhe River Basin located in the North China was selected as model case. The results showed that there were three low risk regions, one medium risk region and two high risk regions in the Luanhe River Basin. The results also indicated habitat destruction was th...

International Nuclear Information System (INIS)

Based on a literature study an actual summary of the risk-utility problems in X-ray diagnosis is outlined due to the Recommendations of the International Commission for Radiation Protection (ICRP publication 26/1977). Papers demonstrating quantitative assessment of the somatic and genetical risk in X-ray examination are preferably cited and evaluated. It is concluded that the somatic and genetical risk is low in diagnostic ratiology. However, it must not be neglected and has always to be compared to the utility of an examination as well as to other risks of the examination. (author).

International Nuclear Information System (INIS)

For the risk estimate of fatal malignancies, an effective dose was proposed on the basis of the assumption that the risk should be equal whether the whole body irradiated uniformly or whether there is non-uniform irradiation. The effective dose was defined by the product of organ or tissue doses and a weighting factor representing the proportion of risk factor for a fatal malignancy resulting from organ or tissue irradiation to the total malignant factor. The risk of malignancies can be derived by multiplying the malignant significant factor by the product of the risk factor and the effective dose. For the genetic risk, a significant factor was a relative child expectancy and organ or tissue doses were gonad doses. And, for the leukemogenic risk, a significant factor was the leukemia significant factor and organ or tissue dose was mean bone ...

UK PubMed Central (United Kingdom)

ObjectiveTo determine whether erectile dysfunction (ED) predicts cardiovascular disease (CVD) beyond traditional risk factors.BackgroundFull Text Available

Energy Technology Data Exchange (ETDEWEB)

Metal oxide semiconductor (MOS) integrated circuits, with the benefits of low power consumption, represent the state of the art technology for implantable medical devices. Three significant sources of radiation are classified as having the ability to damage or alter the behavior of implantable electronics; Secondary neutron cosmic radiation, alpha particle radiation from the device packaging and therapeutic doses(up to 70 G{gamma}) of high energy radiation used in radiation oncology. The effects of alpha particle radiation from the packaging may be eliminated by the use of polyimide or silicone rubber die coatings. The relatively low incidence of therapeutic radiation incident on an implantable device and the use of die coating leaves cosmic radiation induced secondary neutron single event upset (SEU) as the main pervasive ionising radiation threat to the reliability of implantable devices. A theoretical model which predicts the susceptibility ...

International Nuclear Information System (INIS)

In-reactor testing of bolt-loaded compact tension specimens was performed in 360 C water to determine the irradiation-assisted stress corrosion cracking (IASCC) behavior of HTH Alloy X-750 and direct-aged Alloy 625. New data confirm previous results showing that high irradiation levels reduce SCC resistance in Alloy X-750. Heat-to-heat variability correlates with boron content, with low boron heats showing improved IASCC properties. Alloy 625 is resistant to IASCC, as no cracking was observed in any Alloy 625 specimens. Microstructural, microchemical and deformation studies were performed to characterize the mechanisms responsible for IASCC in Alloy X-750 and the lack of an effect in Alloy 625. The mechanisms under investigation are: boron transmutation effects, radiation-induced changes in microstructure and deformation characteristics, and radiation-induced segregation. Irradiation of Alloy X-750 caused significant strengthening and ductility ...

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Introduction: Thalassemia is the most common hereditary blood disorder in the world. Iran is located on the thalassemic belt and there is a high prevalence of the hepatosplenomegaly in beta thalassemia minor patients which is reported to be very variable. The goal of this research was to study the frequency of these signs in the cases with beta thalassemia minor patients in Iran. Materials and methods: Two hundred and fifty-nine cases that referred to center for pre-marriage tests were divided into two groups according to their MCV, MCH, and HbA2 (beta thalassemia minor cases and control groups). Liver and spleen sizes were determined by ultrasonographic method and the two groups were compared with each other. Results: Average spleen volumes in case and control groups were 163.48 {+-} 133.97 and 126.29 {+-} 53.98 mm{sup 3}, respectively. Average spleen lengths in case and control groups were 10.71 {+-} 1.52 and 10.60 {+-} 5.4 cm, respectively. Conclusion: In the ...

International Nuclear Information System (INIS)

From the beginning, one of the most useful applications of Probabilistic Safety Assessment (PSA) is its use in evaluating the risk importance of changes to plant design, operations, or other plant conditions. Risk importance measures the impact of a change on the risk. Risk is defined as a combination of the likelihood of failure and consequence of the failure. The consequence can be safety system unavailability, core melt frequency, early release, or various other consequence measures. The goal in this PSA application is to evaluate the risk importance of an ISI process, as applied to plant piping systems. Two approaches can be taken in this evaluation: Current PSA Approach or the Blended Approach. Both are discussed here.

UK PubMed Central (United Kingdom)

Bone mineral density is considered to be the standard measure for the diagnosis of osteoporosis and the assessment of fracture risk. The majority of fragility fractures occur in patients with bone mineral...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

UK PubMed Central (United Kingdom)

Production agriculture is associated with a variety of occupational illnesses and injuries. Agricultural workers are at higher risk of death or disabling injury than most other workers. Traumatic injury...Full Text Available

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The management of risks of explosives are described. Administrative and procedural controls are considered. The safety management plan involves hazard identification, risk analysis, assessment and control. The current position of explosives safety is considered. 4 tabs.

UK PubMed Central (United Kingdom)

Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well as in patients with chronic kidney disease, but the mechanisms underlying this risk are not completely understood....Full Text Available

UK PubMed Central (United Kingdom)

The existence of thresholds for toxicants is a matter of debate in chemical risk assessment and regulation. Current risk assessment methods are based on the assumption that, in the absence of sufficient...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

There are several methods for the risk assessment and risk management applied to pipelines, among them the Muhlbauer's Method. W. Kent Muhlbauer is an internationally recognized authority on pipeline risk management. He made a detailed identification about 300 distinct conditions that influence the risk assessment in pipelines and he proposed a score system that is known as method of Muhlbauer. The purpose of this model is to evaluate the public exposure to the risk and identify ways for management that risk in fact. The assessment is made by the attribution of quantitative values to the several items that influences in the pipeline risk. This paper approaches the Muhlbauer's basic model for risk assessment and management in pipelines. In the beginning, the basic model for risk ...

International Nuclear Information System (INIS)

On the 3. and 4. November 1982 the sixth conference of the Corporation for Reactor Safety (GRS) was held in Cologne's Guerzenich. The theme of this year's meeting was the 'Status of Risk Investigations at Nuclear Power Plants'. A principal topic was a report on findings made by the GRS during the 'Risk Oriented Analysis SNR-300'. The second topic comprised the newest developments within Phase B of the Risk Study of Water Pressure Reactors, the discussion of the dose/effect relationship and considerations on threshold risk values. (orig.).

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In this study, for the institutionalization of risk informed and performance based regulation in Korea, the latest technical movements of overseas countries are examined and reviewed. And the issues that was found when license change petition using risk information was submitted in Korean regulatory body are reviewed. Based on these review, the applicable areas to domestic situation will be found and proposed. This study can contribute to setting up the proper direction for the institutionalization of risk informed and performance based regulation.

Energy Technology Data Exchange (ETDEWEB)

As competition dramatically reshapes power markets, electric utilities strive to increase flexibility in their commitments and limit exposure to market risks. This paper provides an overview of a promising tool called option valuation which is useful for analyzing and managing risks. The paper demonstrates an application of these techniques for developing new pricing products tailored to meet customers` risk preference.

CSIR Research Space (South Africa)

Full Text Available

Science.gov (United States)

Analyzing the risk of a safeguards system, in particular the security of a computer network based on the notion of fuzzy sets and linguistic variables, addresses concerns such as complexity and inherent imprecision in estimating the possibility of loss or compromise. Automated risk analysis allows the risk to be determined for an entire system based on estimates for lowest level components and the component weight. In addition, for each component (asset) we select the most effective combination of protection mechanisms against a given set of threats.

Science.gov (United States)

PMID:21768762

DEFF Research Database (Denmark)

Udgivelsesdato: 2008-May

Science.gov (United States)

Cardiac Arrest; Coronary Disease; Cardiovascular Risk Factors

Science.gov (United States)

The Seismic Risk Explorer, an extension for ArcGIS Desktop developed by cedim AG, is a tool for computing the seismic risk, i.e. damage on residential buildings and thereby caused monetary losses for earthquake scenarios. It is based on the research results of the CEDIM (Center for Disaster Management and Risk Reduction Technology) research center, located at the Karlsruhe Institute of Technology (KIT) and the GeoForschungsZentrum (GFZ) in Potsdam. With this software tool seismic scenarios can be simulated for a given magnitude, depths and location. The seismic intensity, the resulting mean damage ratio for residential buildings and the seismic risk, expressed as the monetary loss caused by an earthquake can be computed downscaled to communities, postcode areas or even single buildings. Interested end-users are especially insurance companies, but also public authorities which may use the tool for ...

Science.gov (United States)

The risk of cyber attacks on process control networks (PCN) is receiving significant attention due to the potentially catastrophic extent to which PCN failures can damage the infrastructures and commodity flows that they support. Risk management addresses the coupled problems of (1) reducing the likelihood that cyber attacks would succeed in disrupting PCN operation and (2) reducing the severity of consequences in the event of PCN failure or manipulation. The Network Security Risk Model (NSRM) developed in this article provides a means of evaluating the efficacy of candidate risk management policies by modeling the baseline risk and assessing expectations of risk after the implementation of candidate measures. Where existing risk models fall short of providing adequate insight into the efficacy of candidate risk ...

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This paper describes a Qualitative/Screening Methodology included in the draft ANS Low Power and Shutdown (LPSD) PRA (Probabilistic Risk Assessment) Standard. The screening methodology can be used to eliminate certain specified shutdown POSs (Plant Operating States) from requiring further quantitative risk assessment in the context of a specified application based on demonstrating that their risk is lower than some predetermined limiting value. The paper also describes a methodology for qualitative risk assessment (QRA) tools that are used to support the screening process. The paper outlines the bases of both methodologies. (authors)

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The objective of Configuration Risk Management Program(CRMP) is to maintain the safety level by assuring the defense-in-depth of nuclear power plant while the configurations are changed during plant operations, especially for the LP/SD. Such a safety purpose can be achieved by establishing the risk monitoring programs with both quantitative and qualitative features. Generally, the quantitative risk evaluation models, i.e., PRA models are used for the risk evaluation during full power operation, and the qualitative risk evaluation models such as safety function assessment trees are used. Through this study, safety function assessment trees were developed.

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The Screening Risk Evaluation (SRE) guidance document is a set of guidelines provided for the uniform implementation of SREs performed on decontamination and decommissioning (D&D) facilities. Although this method has been developed for D&D facilities, it can be used for transition (EM-60) facilities as well. The SRE guidance produces screening risk scores reflecting levels of risk through the use of risk ranking indices. Five types of possible risk are calculated from the SRE: current releases, worker exposures, future releases, physical hazards, and criticality. The Current Release Index (CRI) calculates the current risk to human health and the environment, exterior to the building, from ongoing or probable releases within a one-year time period. The Worker Exposure Index (WEI) calculates the current risk to workers, occupants and ...

International Nuclear Information System (INIS)

Ionizing radiation, mainly in the form of #gamma#-rays from the radioisotope cobalt 60, is being used increasingly for the inactivation of contaminants in cosmetic and toiletry preparations. The treatment is applied to the product in its final pack, and therefore, it is important to recognize that the properties of the packaging materials could be affected, particularly if high radiation doses are used. The stability of a wide range of materials is discussed. The nature and extent of chemical and physical changes in plastics very much depends on the presence of antioxidants and other additives, and on the environmental conditions during irradiation. Some useful information is available from research into the use of radiation for the preservation of food - many films and laminates have been cleared for use in the United States. The low radiation doses used for the control of contaminants in cosmetic products are quite unlikely to cause changes in packaging materials which will limit the ...

International Nuclear Information System (INIS)

The spectral energy-dependence of the radiation-induced ESR signal has been studied in ovine cortical bone. Crushed bone samples were irradiated using photon beams with effective energies in the range from 0.06 to 6 MeV, and electron beams with mean energies in the range from 2 to 10 MeV. The photon and electron data were normalized to a dose to bone of 50 Gy and the results are reported as response relative to the ESR signal for photon irradiation at 1.25 MeV ("6"0Co). The photon irradiation results show that the ESR response is greatest at low energies with a relative value of 1.2 at 0.06 MeV. The relative response decreases, as the energy increases, to approximately 0.85 in the region of 2 to 3 MeV. These variations in the relative ESR responses are significantly less than the ESR energy-dependent responses reported in the literature for human tooth enamel and synthetic hydroxyapatite. An explanation for this difference is offered. For electron beam ...

International Nuclear Information System (INIS)

The high-energy radiation-induced degradation of an H-acid derivative azo dye, Apollofix-Red SF-28 (AR-28) was studied in aqueous solution by using pulse radiolysis with kinetic spectroscopic detection for transient measurements. Gamma radiolysis with UV-VIS spectroscopy and gradient ionpair HPLC separation with diode array detection were applied for following the destruction of AR-28 and measuring the products. The reactions of hydrated electron (e_a_q "-) and hydroxyl ("#centre dot#OH) radical were investigated separately. "#centre dot#OH reacts with the unsaturated bonds of the molecule. In the further reactions of the "#centre dot#OH adduct radicals, the AR-28 molecules partly reform with a slightly modified structure. The products formed in the first reaction of "#centre dot#OH and AR-28 molecules have also high reactivity towards the "#centre dot#OH radicals. For these reasons the efficiency of "#centre dot#OH radicals in discolouration of the solution is ...

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Poly(methyl methacrylate), PMMA, Acrigel, a Brazilian polymer, is used in the manufacture of medical supplies sterelizable by ionizing radiation. However, when PMMA is gamma-irradiated it undergoes main chain scissions, which promote molecular degradation causing reduction in its mechanical properties. Therefore, radiolytic of PMMA is important for it to become commercially radiosterizable. In this work some commercial additives, originally used in photo-and thermo-oxidate stabilization of polymers, were tested. Only two additives, type HALS (Hindered Amine Light Stabilizer), denoted Scavenger, showed a good protective quality. The investigation of radiation-induced main scissions was carried out by viscosimetric method. The most effective additive, added to the polymer system at 0.3 w/w%, promotes a great molecular radioprotection of 93%. That means a reduction of G-value (scissions/100 eV) from 0.611 to 0.053. In addition, the glassy transition temperature (T{sub ...

International Nuclear Information System (INIS)

In experiments designed to detect new mutations affecting hemoglobin, we irradiated the male or female parent in reciprocal crosses of two mouse strains that differ in alleles at the hemoglobin (Hba, Hbb) loci as well as at five other specific loci. Offspring were analyzed for hemoglobin properties (electrophoretic pattern, solubility, crystal pattern), serum albumin differences, erythrocyte lysis, reticulocyte count, and external appearance. Five hemoglobin variants were found among the mutants. In three, the genetic contribution from the irradiated father was not expressed with regard to the #alpha#-chain; one carried a tandem duplication (the first known case in the mouse) involving Hbb; and one probably resulted from double nondisjunction of chromosome 7. The finding that major chromosome aberratios can mimic hemoglobin mutations indicates the need, in similar experiments, to follow F_1 screening with thorough cytogenetic analysis. The variants in which there is nonexpression of ...

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Wood sawdust has been applied to manufacture the sawdust-clay-plastic composite (SDCPC) by radiation process for the purpose of disposing large amount of wood sawdust waste material. The process comprises the impregnation of liquid vinyl monomers into the completely dried molded sawdust-clay specimens followed by exposure to Co-60 gamma-radiation to induce graft-copolymerization of the impregnated vinyl monomers onto the sawdust-clay matrix. The comonomer system of unsaturated polyester and vinyl compounds was found to be the ideal impregnating monomer for the preparation of the SDCPC from the viewpoint of the technological and economical advantages. The SDCPC material has a variety of the sawdust content which enables the composite to have wide range of mechanical properties, e.g., 410 to 1100 kg/cm/sup 2/ in compressive strength, 120 to 380 kg/cm/sup 2/ in tensile strength and 0.32 to 4.41 kg/mm/sup 2/ in static bending strength. The SDCPC having higher content of clay (more than 50% ...

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The in situ assembly states of the glucose transport carrier protein in the plasma membrane and in the intracellular (microsomal) storage pool of rat adipocytes were assessed by studying radiation-induced inactivation of the D-glucose-sensitive cytochalasin B binding activities. High energy radiation inactivated the glucose-sensitive cytochalasin B binding of each of these membrane preparations by reducing the total number of the binding sites without affecting the dissociation constant. The reduction in total number of binding sites was analyzed as a function of radiation dose based on target theory, from which a radiation-sensitive mass (target size) was calculated. When the plasma membranes of insulin-treated adipocytes were used, a target size of approximately 58,000 daltons was obtained. For adipocyte microsomal membranes, we obtained target sizes of approximately 112,000 and 109,000 daltons prior to and after insulin treatment, respectively. In the case of ...

International Nuclear Information System (INIS)

Total-dose irradiation seriously damages MOS devices and their circuit performance. Threshold voltage shifts, transconductance degradation and increase in off-state leakage current are generally observed for irradiated devices. These instabilities are essentially due to positive and/or negative charge trapping in SiO_2 and interface trap generation at the SiO_2/Si interface. Radiation hardening of CMOS VLSIs is to eliminate these trapping effects, and for this purpose, special considerations for fabrication processes and layout design are necessary. In this paper, basic mechanisms for radiation-induced charge trapping and related effects on MOS devices are reviewed. Also discussed are radiation-hardening technologies from both fabrication-process and layout-design viewpoints. Using these technologies, 1 #mu#m radiation-hard CMOS gate arrays have been successfully developed. Experimental data taken for 2k-gate test chips indicate that radiation hardness of these ...

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The adverse effect of moisture diffusion on the properties of wood has been one of the main weaknesses of wood. Using a gamma irradiation method, wood-polymer composites have been produced which exhibit significant improvement in mechanical properties like compression, creep deformation and creep rupture particularly at high humidity. It has been thought that the impregnation of polymer into the wood has affected the moisture diffusion in the wood, so that its adverse effects on the mechanical properties has been reduced. In this report the apparent diffusion coefficients of a Ramin wood impregnated with varying amounts of polymethyl methacrylate (PMMA) were determined using a Fick's law approach. An initial linear relationship was found for impregnation of up to 70% PMMA, after which the diffusion coefficient levels off to a maximum value, for the three environmental relative humidity levels of 40, 60 and 90({plus minus}5)%. The phenomenon could be explained by means of a ...

Energy Technology Data Exchange (ETDEWEB)

The electrical conductivity of Vitox-alumina (99.2%), Wesgo-alumina (99.9%) and AlN (99.6%) has been measured during and after irradiation with an experimental set-up which allows fusion relevant loading conditions. All irradiations were performed in high vacuum at 450 C using a 104 MeV {alpha}-particle beam with an applied DC electric field of 100 kV/m. In the high purity Vitox-alumina the in-situ and postirradiation bulk conductivities {sigma} and {sigma}{sub 0} show the highest irradiation induced electrical breakdown ever observed. The saturation level near 4 x 10{sup -2} ({Omega}m){sup -1}, reached already after 0.015 dpa (O-sublattice), is already above the critical value necessary to avoid MHD pressure drop with 10 {mu}m coatings in flowing liquid metal coolants. Under the same conditions no radiation induced electrical degradation at all has been found in Wesgo-alumina and AlN. (orig.).

International Nuclear Information System (INIS)

Thermoluminescence (TL) dosimetry was used to measure dose effects on the raw stock material of borosilicate container glass from different geographical locations. Effects were studied at times up to 60 days post-irradiation at doses from 0.15 to 20 Gy. The minimum detectable dose using this technique was estimated to be 0.15 Gy which is roughly equivalent to a 24 hr irradiation 1 cm from a 50 ng source of 60Co. Two peaks were identified in the TL glow curve, a relatively unstable peak around 125 C and a more stable peak around 225 C. Differences in TL glow curve shape and intensity were also observed for the glasses from different geographical origins. We investigate radiation induced defects in glass to further develop the technique of intrinsic dosimetry - the measurement of the total absorbed dose received by the walls of a container holding radioactive material. Intrinsic dosimetry is intended to be used as an interrogation tool to provide ...

Energy Technology Data Exchange (ETDEWEB)

For an assessment of the future US spallation neutron source (SNS) target performance, radiation induced hardening and microstructural evolution were investigated as a function of ion dose for EC316LN stainless steel. Irradiation was carried out using 3.5 MeV Fe{sup +}, 360 keV He{sup +}, and 180 keV H{sup +} simultaneous ion-beams at 200 deg. C to simulate the damage, He and H production in the SNS target vessel wall. At low dose (< 1 dpa), the predominant defects were black dots whose number density saturated rapidly within a few dpa. This was followed by the evolution of interstitial loops whose number density saturated below 15 dpa. Although He-bubbles were not visible, severely scalloped loops suggested that the implanted He/H atoms existed in the form of small clusters. Comparison with reported neutron irradiation data showed that hardening and ductility loss occurred mostly in the black dot regime (< 1 dpa), but that good ...

International Nuclear Information System (INIS)

The application of robotics for repair, refurbishing or dismantling of nuclear installations implies eventually severe radiation resistance requirements on embarked components and subsystems. This is particularly critical when optical sensing is considered. Optoelectronic components and optical fibers are indeed quite sensitive to radiation, and without special design are rapidly out-of-operation in such an environment. This paper reports the results of a series of #gamma# irradiation experiments on such devices, and identify their behavior under radiation. Test results show that carefully selected optical fibers can keep their radiation induced attenuation lower than 0.3 dB/m even up to a total dose of 10 MGy. Temperature annealing can even lower this attenuation down to 0.1 dB/m. On the other hand, commercially available light emitting diodes and photodiodes present attenuations figures up to 15 dB, even after a gamma irradiation as low as ...

Energy Technology Data Exchange (ETDEWEB)

Aluminum nitride has been proposed as electrically insulating coating in connection with blankets made of vanadium alloys. Irradiations were performed with an applied DC electric field of 100 kV/m, using a 104 MeV {alpha}-particle beam. The dose achieved were 0.1 dpa at 300 C, 0.05 dpa at 400 C, and 0.06 dpa at 500 C. The out-of-beam conductivity {sigma}{sub 0} decreased at all temperatures employed during early stage of irradiation. Before 0.02 dpa had been reached, {sigma}{sub 0} dropped to low values of typically (2-4) x 10{sup -11} ({Omega} m){sup -1}. Although a moderate increase can be observed during further irradiation, {sigma}{sub 0} remained below the initial value of the unirradiated specimen for all temperatures. That is, there is no significant evidence for radiation induced electrical degradation. The in-beam conductivity {sigma}, measured continuously during irradiation, also decreased by at least one order of magnitude. Relevant ...

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Effect of radiation dose and carbon nanotubes (CNT) on the mechanical properties of standard Malaysian rubber (SMR) was investigated in this study. SMR nanocomposites containing 1-7 phr CNT were prepared using the solvent casting method and the nanocomposites were radiated at doses of 50-200 kGy. The change in mechanical properties, especially, tensile strength (Ts), elongation at break (Eb), hardness and tensile modulus at 100% elongation (M{sub 100}) were studied as a function of radiation dose. The structure and morphology of reinforced natural rubber was investigated by FESEM, TEM and AFM in order to gain further evidence on the radiation-induced crosslinking. It was found that the Ts, M{sub 100} and the hardness of the SMR/CNT nanocomposites significantly increased with radiation dose; the elongation at break exhibited an increase up to 100 kGy, and a downward trend thereafter. Results on gel fraction further confirmed the crosslinking of SMR/CNT ...

International Nuclear Information System (INIS)

Alloy HT-9 is being used for both duct and cladding applications in advanced liquid-metal reactor (LMR) experiments. This tempered martensitic steel was selected for use as an LMR core component material primarily because of its excellent resistance to radiation-induced swelling. Experiments conducted in the Fast Flux Test Facility (FFTF) at 410 degree C and exposures in the range of 150 to 175 displacements per atom (dpa) have shown that Ht-9 exhibits only a 0.2 to 0.3% increase in volume. Cold-worked austenitic steels exhibit volumetric increases of 20 to 30% at 410 degree C, Alloy HT-9 is being used for a series of fuel pin experiments in the FFTF, and these tests have achieved a burnup of 175 MWd/kg metal and a fluence of 25 x 10"2"2 n/cm"2 (E > 0.1 MeV) without fuel pin breach. The high confidence placed in HT-9 is based on a wide series of in- and ex-reactor experiments. Test results for these experiments are summarized in this paper.

International Nuclear Information System (INIS)

The work scope of 'Biological Research for the Radiation Protection' had contained the research about ornithine decarboxylase and its controlling proteins, thioredoxin, peroxiredoxin, S-adenosymethionine decarboxylase, and glutamate decarboxylase 67KD effect on the cell death triggered ionizing radiation and H_2O_2(toxic agents). In this study, to elucidate the role of these proteins in the ionizing radiation (or H_2O_2)-induced apoptotic cell death, we utilized sensesed (or antisensed) cells, which overexpress (or down-regulate) RNAs associated with these proteins biosynthesis, and investigated the effects of these genes on the cytotoxicity caused by ionizing radiation and H_2O_2(or paraquat). We also investigated whether genisteine(or thiamine) may enhance the cytotoxic efficacy of tumor cells caused by ionizing radiation (may enhance the preventing effect radiation or paraquat-induced damage) because such compounds are able to potentiate the cell-killing or cell protecting effects. ...

Energy Technology Data Exchange (ETDEWEB)

The overall objective of this project has been to develop immunochemical methods to quantitate unique DNA base damages in order to facilitate studies on radiation-induced damage production and repair. Specifically, we have been using antibodies raised to damaged bases to quantitate unique lesions in model systems in order to evaluate their potential biological consequences. Our approach has been to synthesize modified nucleotides or nucleosides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits or to prepare monoclonal antibodies. We have been studying damages that are stable radiolysis products found in X-irradiated DNA and thus of potential biological consequence. Our aim is to build an in vitro and in vivo data base on the interactions between model DNA lesions and such cellular enzymes as DNA polymerases and repair endonucleases. Initial studies have focused on pyrimidine ring saturation products (thymine glycol.and ...

Science.gov (United States)

Two hazard risk assessment matrices for the ranking of occupational health risks are described. The qualitative matrix uses qualitative measures of probability and consequence to determine risk assessment codes for hazard-disease combinations. A walk-through survey of an underground metalliferous mine and concentrator is used to demonstrate how the qualitative matrix can be applied to determine priorities for the control of occupational health hazards. The semi-quantitative matrix uses attributable risk as a quantitative measure of probability and uses qualitative measures of consequence. A practical application of this matrix is the determination of occupational health priorities using existing epidemiological studies. Calculated attributable risks from epidemiological studies of hazard-disease combinations in mining and minerals processing are used as examples. These historic ...

International Nuclear Information System (INIS)

As part of the Nondestructive Evaluation Reliability Program sponsored by the US Nuclear Regulatory Commission, the Pacific Northwest Laboratory is developing a method that uses risk-based approaches to establish in-service inspection plans for nuclear power plant components. This method uses probabilistic risk assessment (PRA) results and Failure Modes and Effects Analysis (FEMA) techniques to identify and prioritize the most risk-important systems and components for inspection. The Surry Nuclear Power Station Unit 1 was selected for pilot applications of this method. The specific systems addressed in this report are the reactor pressure vessel, the reactor coolant, the low-pressure injection, and the auxiliary feedwater. The results provide a risk-based ranking of components within these systems and relate the target risk to target failure probability values for individual ...

British Library Electronic Table of Contents (United Kingdom)

ABSTRACT Traditional risk-based design process involves designing the structure based on risk estimates obtained during several iterations of an optimization routine. This approach is computationally expensive for large-scale aircraft structural systems. Therefore, this paper introduces the concept of risk-based design plots that can be used for both structural sizing and risk assessment for fracture strength when maximum allowable crack length is available. In situations when crack length is defined as a probability distribution the presented approach can only be applied for various percentiles of crack lengths. These plots are obtained using normalized probability density models of load and material properties and are applicable for any arbitrary load and strength values. Risk-based desi...

British Library Electronic Table of Contents (United Kingdom)

BACKGROUND: Glyphosate resistance has been confirmed in 58 populations of Lolium rigidum (Gaud.), a major weed of crops in southern Australia. Extensive use of glyphosate in conjunction with minimal soil disturbance has been identified as high risk for resistance to that herbicide. Land managers need a simple method for rapid assessment of the risk of resistance occurring as a result of past and proposed future management practices. Modelled on risk assessment nomographs, a simple calculator for indicating the risk of evolved glyphosate resistance in L. rigidum is described.RESULTS: The calculator uses the generations since first use and the frequency of use of glyphosate in combination with historical cultivation levels as critical factors for determining the risk of glyphosate resistance...

Science.gov (United States)

The somatically significant dose index can be considered as a measure for the somatic radiation risk to which the population is exposed. Figures are stated for conventional tomography of the skull and thorax. These are compared with the corresponding data for other x-ray examinations, especially computerised tomography. PMID:7134769

UK PubMed Central (United Kingdom)

Invasive species are increasingly becoming a policy priority. This has spurred researchers and managers to try to estimate the risk of invasion. Conceptually, invasions are dependent both on the receiving...Full Text Available

UK PubMed Central (United Kingdom)

Sunbed use is associated with increased risk of melanoma. Younger people might be more susceptible to the carcinogenic effects of ultraviolet radiation. We investigated the association between...Full Text Available

International Nuclear Information System (INIS)

The somatically significant dose index can be considered as a measure for the somatic radiation risk to which the population is exposed. Figures are stated for conventional tomography of the skull and thorax. These are compared with the corresponding data for other X-ray examinations, especially computerised tomography. (orig.).

UK PubMed Central (United Kingdom)

Objectives To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental,...Full Text Available

UK PubMed Central (United Kingdom)

This research focuses on young Mexican American girls who are not formal gang members yet participate in street-based activities of male gangs and engage in risk behaviors. These females comprise...Full Text Available

UK PubMed Central (United Kingdom)

The authors’ objective was to analyze the impact of respiratory impairment on the risk of physical functional limitations among adults with chronic obstructive pulmonary disease (COPD)....Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVETo determine the association between 25-hydroxyvitamin D (25-OHD) concentration and risk of incident type 2 diabetes.RESEARCH DESIGN AND METHODSIn...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The Boiler and Pressure Vessel Code (BPVC) of the American Society of Mechanical Engineers (ASME) has introduced a risk based approach into Section XI that covers Rules for Inservice Inspection of Nuclear Power Plant Components. The risk based approach requires application of the probabilistic risk assessments (PRA). Because no industry consensus standard existed for PRAs, ASME has developed a standard to evaluate the quality level of an available PRA needed to support a given risk based application. The paper describes the PRA standard, Section XI application of PRAs, and plans for broader applications of PRAs to other ASME nuclear codes and standards. The paper addresses several specific topics of interest to Section XI. Important consideration are special methods (surrogate components) used to overcome the lack of PRA treatments of passive components in PRAs. The approach allows calculations of ...

UK PubMed Central (United Kingdom)

IntroductionWhile epidemiological methods have grown in sophistication during the 20^th century, their application in historical occupational (and environmental) health...Full Text Available

UK PubMed Central (United Kingdom)

To elucidate problems with microfungal infestation in indoor environments, a multidisciplinary collaborative pilot study, supported by a grant from the Danish Ministry of Housing and Urban Affairs,...Full Text Available

UK PubMed Central (United Kingdom)

This study sought to assess the association between traditional masculine gender role ideologies and sexual risk and intimate partner violence (IPV) perpetration behaviors in young men's heterosexual...Full Text Available

UK PubMed Central (United Kingdom)

ObjectiveTo investigate possible differences in operative delivery rate among low-risk women, randomised to an alongside midwifery-led unit or to standard obstetric units within...Full Text Available

UK PubMed Central (United Kingdom)

A collaborative research effort by scientists in several states and in Canada has produced information to develop a formal risk assessment of the impact of Bt corn on monarch butterfly...Full Text Available

International Nuclear Information System (INIS)

Hospital wastes comprises approximately 80% domestic waste components, also known as non-risk waste and 20% hazardous or risk waste. The 20% of the hospital waste stream or the risk waste (also known as infectious, medical, clinical wastes) comprises components which could be potentially contaminated with infections, chemical or radioactive agents. Therefore, it should be handled and disposed of in such a manner as to minimize potential human exposure and cross-contamination. Hospital risk waste and be subdivided into seven general categories as follows: infections, anatomical/pathological, chemical, pharmaceutical, radioactive waste, sharps and pressurised containers. These waste categories are generated by many types of health care establishments, including hospitals, clinics, infirmaries.... The document presents also tables of number of hospitals and estimated bed number in different regions in ...

UK PubMed Central (United Kingdom)

Purpose:The risks and benefits of continuing bisphosphonate therapy beyond 5 years in patients with primary osteoporosis have not been well established.Methods:We...Full Text Available

UK PubMed Central (United Kingdom)

At least implicitly, most clinical decisions represent an integration of disease and treatment-based risk assessments. Often, as is the case with acute coronary syndrome (ACS), these decisions need...Full Text Available

International Nuclear Information System (INIS)

Background: The effective-dose method which was proposed by the ICRP (International Commission of Radiation Protection) for the estimation of risk to the general population from occupational or environmental, low-dose radiation exposure is not adequate for estimating the risk of cancer induction by radiotherapy of malignant or nonmalignant diseases. Methods:The risk of cancer induction by radiotherapy of benign diseases should be based on epidemiologic data directly derived from follow-up studies of patients who had been given radiotherapy for nonmalignant diseases in the past. Results: Risk factors were derived from epidemiologic studies of patients treated with irradiation for nonmalignant diseases to be used for selecting treatment options and optimizing treatment procedures. Conclusion: In most cases, cancer risks estimated by the effective-dose method may overestimate the true ...

UK PubMed Central (United Kingdom)

ObjectiveThe aim of this study was to ascertain whether all cervical cancer patients who received adjuvant concurrent chemoradiation (CCRT) for high risk of treatment failure after...Full Text Available

UK PubMed Central (United Kingdom)

AIMSTo evaluate and compare the risk of specific safety outcomes in patients prescribed ibuprofen and paracetamol concomitantly with those in patients prescribed ibuprofen or paracetamol...Full Text Available

UK PubMed Central (United Kingdom)

The ethical dimension of treating the elderly, including risk–benefit analysis, focuses mainly on quality of life and end-of-life issues. These include arguments on advance directives and the...Full Text Available

UK PubMed Central (United Kingdom)

Carotid artery stenosis is a major risk factor for stroke, and treatments for this condition to decrease the risk of stroke include medical therapy, carotid endarterectomy (CEA), and, more recently,...Full Text Available

UK PubMed Central (United Kingdom)

Current pesticide health risk assessments in the United States require the characterization of aggregate exposure and cumulative risk in the setting of food tolerances. Biologic monitoring can aggregate...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThis is a preliminary report of an ongoing prospective bimodality lung cancer surveillance trial for high‐risk patients. Bimodality surveillance incorporates autofluorescence...Full Text Available

UK PubMed Central (United Kingdom)

Numbers of non-indigenous species--species introduced from elsewhere - are increasing rapidly worldwide, causing both environmental and economic damage. Rigorous quantitative risk-analysis frameworks,...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe aim of this cohort study was to quantify the effect of alcohol in the risk of oral cancer in different strata of folate intake, controlling for known...Full Text Available

UK PubMed Central (United Kingdom)

This study examines the longitudinal relationship between personal and sexual partner incarceration and subsequent HIV risk behaviors among drug-involved men and their primary female sexual...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The study required by the West German Ministry of Research and Technology (RS 605) for the Committee on 'Future Nuclear Energy Policy' of the 9th German Parliament is concerned with the following main points: 1) Assessment of technical risks from the social aspect; 2) Discussion of terms and quantification of risks; 3) 'Engineering judgment' and 'questionable' methods in the Fast Breeder analysis of the Society for Reactor Safety (GRS); 4) Assessment criteria of potential damage.

International Nuclear Information System (INIS)

... body body areas diagnostic techniques hazards health hazards mammals

Science.gov (United States)

ASME PRA STANDARD FOR PRA. FOR NPP APPLICATION. " Provides a Standard for performing and using a. PRA. Definitions. Risk assessment ...

Energy Technology Data Exchange (ETDEWEB)

(B204)Probabilistic risk assessment (PRA) insights are now used by the United States Nuclear Regulatory Commission (USNRC) to confirm the level of safety for plant operations and to justify changes in nuclear power plant operating requirements, both on an exception basis and as changeds to a plant's licensing basis. This report examines qualitative and quantitative risk assessments during shutdown plant states, providing feedback to utilities in the use of qualitative models for outage risk management, and also providing input to the development of the American Nuclear Society (ANS) Low Power and Shutdown PRA Standard.

International Nuclear Information System (INIS)

Computer software for risks assessment of transportation of important freight has been developed. It incorporates models of transport accidents, including terrorist attacks. These models use, among the others, unput data of cartographic character. Geographical information system technology and electronic maps of an area are involved as an instrument for handling this kind of data. Fuzzy set theory methods as well as standard methods of probability theory have been used for quantitative risk assessment. Fuzzy algebraic operations and their computer realisation are discussed. One preliminary example of risk assessment is described. (authors)

DEFF Research Database (Denmark)

Udgivelsesdato: 2004-Apr

Science.gov (United States)

... Accession Number : ADA326934. Title : Analyzing and Improving Stochastic Network Security: A Multicriteria Prescriptive Risk Analysis Model. ...

Science.gov (United States)

PMID:16912339

Energy Technology Data Exchange (ETDEWEB)

The volume contains reports on plant technology, on systems organisation with the aim to minimize the risk (human error), on the problem of seismic risk, on core-disruptive accidents and on accident consequence models with different release categories and a comparison of the potential damage incurred. Mr. Webb; one of the authors, attempts to disprove the objections to his two earliest SNR statements by experts of Karlsruhe Nuclear Research Centre.

International Nuclear Information System (INIS)

The article applies the Probability Safety Assessment approach to analyze the risk impact of extension of allowed outage time of emergency diesel generator in Daya Bay NPP and adopts the risk-acceptance criteria used by NRC to evaluate changes to the licensing basis. The assessment results show that the risk impact is acceptable to increase the emergency diesel generator allowed outage time from 3 days to 14 days. (authors)

International Nuclear Information System (INIS)

In this study, a probabilistic seismic risk analysis of the Wolsung NPP containment building was performed by a seismic hazard analysis and a seismic fragility analysis based on the nonlinear dynamic time-history analyses. The conventional seismic fragility analysis of the safety related structures in a NPP have been performed by using the linear elastic analysis results. The probabilistic seismic risk of the containment building was 5.19e-8.

Environmental Research Database

DescriptionThe initiative on risk assessment and toxicology arose in 1995 when the limitations of current methods of risk assessment and the possibilities offered by new options were identified. Government Departments agreed to explore with the Research Councils how a joint strategy could be focused on the Departments' policy needs. In October 2002 the Steering Committee reviewed the work of IGHRC and recommended that the Initiative should continue for a further three years (October 2003 - September 2006 [continued...

International Nuclear Information System (INIS)

The risks from radiation exposure during radiological diagnosis has usually been estimated in relation to genetic changes. Relevant information has been expressed as the genetically significant dose. In this paper we attempt to produce an analogous measure for evaluating the somatic risk in the form of a somatically significant dose index for radiological and CT examinations. It is shown that, for both types of examination, the two risk factors may be entirely different. (orig.).

Energy Technology Data Exchange (ETDEWEB)

Specifically this report: 1. Compares requirements of the WAP that are pertinent from a technical viewpoint with the WIPP pre-Permit waste characterization program, 2. Presents the results of a risk analysis of the currently emplaced wastes. Expected and bounding risks from routine operations and possible accidents are evaluated; and 3. Provides conclusions and recommendations.

International Nuclear Information System (INIS)

Late somatic and genetic radiation effects are imperfectly understood, particularly in the human species. However the available information is sufficient to draw reasonably precise risk estimates in man for many types of damage by means of scientifically justifiable procedures and with the necessary caution. This overall absolute risk of major somatic and genetic damage may be set at around 10"-"4/rad of chronic whole-body doses.

International Nuclear Information System (INIS)

The penetrance of Leber's hereditary optic neuropathy (LHON) in families with primary mitochondrial DNA (mtDNA) mutations is very complex. Matrilineal and nuclear genetic background, as well as environmental factors, have been reported to be involved in different affected pedigrees. Here we describe two large Chinese families that show a striking difference in the penetrance of LHON, in which 53.3% and 15.0% of members were affected (P < 0.02), respectively. Analysis of the complete mtDNA genome of the two families revealed the presence of the primary mutation G11778A and several other variants suggesting the same haplogroup status G2a. The family with higher penetrance contained a previously described secondary mutation G13708A, which presents a polymorphism in normal Chinese samples and does not affect in vivo mitochondrial oxidative metabolism as described in a previous study. Evolutionary analysis failed to indicate any putatively pathogenic mutation that ...

International Nuclear Information System (INIS)

Full text: Disorders of brain development and phakomatosis are resulting from disturbed embryonic-foetal development One third of all major embryological anomalies involve CNS, and over 2000 different anomalies have been described. Anomalies of the brain often cause foetal and neonatal death, and mental and physical retardation in pediatric group. The majority of disorders of brain development and phakomatosis are idiopathic, and most of them are not hereditary or familial. Ultrasonography plays the important role in screening foetal and neonatal brain, but after closure of fontanels it is difficult to find the acoustic window. CT has limited contrast resolution, and disadvantage exposing infant to ionizing radiation. It is helpful to demonstrate the presence of calcifications. MR imaging has proved to be a diagnostic tool of major importance in children with disorders of brain development and phakomatosis. The excellent grey/white matter differentiation and ...

Energy Technology Data Exchange (ETDEWEB)

The scope of this RA is limited to the evaluation of potential human health risks associated with a failure event of a tank containing Basin F liquid. Section 1.0 contains an introduction to the health risk assessment. Section 2.0 describes the site history, location, and land use. Section 3.0 provides a brief description of exposure pathways and potention receptors. Section 4.0 describes the sources of data used and identifies chemicals of concern. Section 5.0 discusses the toxicity of concern. Section 6.0 explains the methods used for calculation of carcinogenic risks and the noncarcinogenic hazard indexes. Section 7.0 describes uncertainties inherent in the current methodology used to determine potential human health risks. Section 8.0 presents a summary of results and conclusions. Section 9.0 includes the references cited.

British Library Electronic Table of Contents (United Kingdom)

How do police respond to and manage complaints of stalking? To answer this question, we conducted a 3-phase study. First, we reviewed the literature to identify risk management tactics used to combat stalking. Second, we asked a group of police officers to review those tactics for completeness and group them into categories reflecting more general risk management strategies. The result was 22 categories of strategies. Finally, we used qualitative methods to evaluate the files of 32 cases referred to the specialized anti-stalking unit of a metropolitan police department. We coded specific risk management tactics and strategies used by police. Results indicated that a median number of 19 specific tactics from 7 general strategies were used to manage risk. Also, the implementation of strategi...

British Library Electronic Table of Contents (United Kingdom)

Background Despite potentially relevant chemical differences between filtered and boiled coffee, this study is the first to investigate consumption in relation to the risk of incident cancer. Methods Subjects were from the V?sterbotten Intervention Project (64,603 participants, including 3,034 cases), with up to 15?years of follow-up. Hazard ratios (HR) were calculated by multivariate Cox regression. Results No associations were found for all cancer sites combined, or for prostate or colorectal cancer. For breast cancer, boiled coffee ?4 versus <1 occasions/day was associated with a reduced risk (HR?=?0.52, CI?=?0.30?0.88, p trend?=?0.247). An increased risk of premenopausal and a reduced risk of postmenopausal breast cancer were found for both total (HRpremenopausal?=?1.69, CI?=?0.96?2.98...

British Library Electronic Table of Contents (United Kingdom)

The article maps the risk management failures within Anglo Irish Bank, showing that, when banks are systemic in nature, poor internal corporate governance within a Minsky credit cycle can lead to destabilising macroeconomic conditions, which may prolong the effects of a credit-induced downturn. The article highlights a failure of management at Anglo Irish Bank to establish and measure firm-level risks and develop appropriate internal controls to support a culture of prudent credit management. We propose the adoption of a novel supervisory architecture based on the meta-risk regulatory philosophy, which is designed to strengthen risk management practices at banks.

DEFF Research Database (Denmark)

OBJECTIVES: The authors examine the rationale and efficacy of pre-travel hepatitis B immunization strategies based on itinerary and presumed on-travel risk behaviour. METHODS: A large survey among 26,640 Danes survey provided data on journey lengths and destinations, immunization coverage, risk behaviour and knowledge. RESULTS: The estimated cumulative lifetime stay in endemic areas outside Europe is 4.3 months. The majority of risk situations are involuntary and unforeseeable. The majority of risk situations occur on short-term journeys. 5% nonimmune and 5% short-term travellers experienced at least one risk situation such as injections/operations/tattoos on their journey. The level of knowledge of hepatitis A and B is low. CONCLUSIONS: The rationale and efficacy of current immunization strategies are challenged. Based on the results presented here and the availability of vaccines ...

Energy Technology Data Exchange (ETDEWEB)

A risk-based sensor placement methodology is proposed to solve the problem of optimal location of sensors or detectors to protect population against the exposure to and effects of known and/or postulated chemical, biological, and/or radiological threats. Risk is calculated as a quantitative value representing population at risk from exposure against standard exposure levels. Historical meteorological data are used to characterize weather conditions as the frequency of wind speed and direction pairs. The meteorological data drive atmospheric transport and dispersion modeling of the threats, the results of which are used to calculate risk values. Sensor locations are determined via an iterative dynamic programming algorithm whereby threats captured or detected by sensors placed in prior stages are removed from consideration in subsequent stages. In addition to the risk-based placement ...

International Nuclear Information System (INIS)

In the 5th year of the Japan International Cooperation Agency (JICA) Technical Cooperation Project 'Seismic Risk Reduction for Buildings and Structures in Romania', the implementing agency - National Center for Seismic Risk Reduction (NCSRR) and JICA jointly organized the International Symposium on Seismic Risk Reduction (ISSRR-2007) held in Bucharest at the Romanian Academy Library in the period April 26-27, 2007. The present volume contains the Proceedings of the International Symposium on Seismic Risk Reduction, ISSRR-2007. The Proceedings are organized in three parts: (I) keynote lectures, (II) papers on the results of JICA Project in Romania and (III) contributions from authors. Eight keynote lectures by specialists from Japan, USA, France and Greece, and fourteen papers on the results of JICA Project are included. The contributions from authors are divided in five sections: (i) Seismicity, Seismic ...

Energy Technology Data Exchange (ETDEWEB)

The risk assessment report for gasoline was discussed at the EU TCNES (Technical Committee for New and Existing Substances) on 1 December 2004. CONCA WE was represented at the meeting by Tom Parkerton (EMBSI), Peter Boogaard (Shell),Jan Urbanus (CONCA WE) and Duncan King (BP). First a short introduction to CONCAWE was given, followed by a summary of the on-going programme of risk assessments on groups of petroleum substances. The methodology and outline conclusions for the environmental and health risk assessment for gasoline were then presented. Member States were invited to comment on the draft risk assessment. It was clear that not ail of the Member States had yet reviewed the report in detail (it had been circulated to the Member States approximately 5 weeks in advance of the meeting). However, those that did provide comments (along with ail of all European Chemicals Bureau representatives) were ail ...

Energy Technology Data Exchange (ETDEWEB)

Austenitic 316LN alloy was ion-irradiated using the unique Triple Ion Beam Facility (TIF) at ORNL to investigate radiation damage effects relevant to spallation neutron sources. The TIF was used to simulate significant features of GeV proton irradiation effects in spallation neutron source target materials by producing displacement damage while simultaneously injecting helium and hydrogen at appropriately high gas/dpa ratios. Irradiations were carried out at 80, 200, and 350 C using 3.5 MeV Fe{sup ++}, 360 keV He{sup +}, and 180 keV H{sup +} to accumulate 50 dpa by Fe, 10,000 appm of He, and 50,000 appm of H. Irradiations were also carried out at 200 C in single and dual ion beam modes. The specific ion energies were chosen to maximize the damage and the gas accumulation at a depth of {approximately} 1 {micro}m. Variations in microstructure and hardness of irradiated specimens were studied using transmission electron microscopy (TEM) and a nanoindentation technique, respectively. TEM ...

International Nuclear Information System (INIS)

In this paper we discuss the results of thermoluminescence (TL) studies carried out on freshly quenched crystals of KBr doped with #approx# 50 ppm of Eu"2"+ ions which were X-irradiated at room temperature. The TL glow curve of this phosphor material consists of three glow peaks at 355, 376 and 398 K whose intensities increased as a function of X-irradiation time. The TL glow peaks were analyzed by the total curve-fitting method in order to obtain the characteristic parameters; activation energy, pre-exponential factor and kinetic order. The spectral character of the emission recorded during thermoluminescence was found to be the same for all glow peaks and consists of a broad band centered at #approx# 420 nm. It is proposed that the model of the TL process most consistent with our experimental results is one in which the Eu"2"+ impurity acts as an electron trap during the irradiation process and that the radiation induced center (partner of an ...

International Nuclear Information System (INIS)

Nitroaromatic radiosensitizers become metabolically bound preferentially to hypoxic cells and at least 10/sup 9/ adducts/cell can be tolerated as non-toxic. EMT-6 tumor cells have been incubated in hypoxia in the presence of /sup 3/H-Misonidazole and /sup 125/I-Azomycin Riboside for various times and the amount of /sup 3/H or /sup 125/I bound/cell was determined. Cells were stored as monolayers at 25"0C for up to 96 hr to accumulate radioactive decays and transferred at various times to 37"0C for colony-forming assays. No radiation inactivation was measured in cells which had incorporated at least 10/sup 6/ /sup 3/H or 10/sup 5/ /sup 125/I atoms. Previous studies had shown that -- 1% of MISO adducts to EMT-6 cells was associated with cellular DNA. These data indicate that the radiation-induced damage produced by these quantities of bound /sup 3/H or /sup 125/I causes little or not cell inactivation. The results of current studies to measure the colony-forming ...

International Nuclear Information System (INIS)

In the use of doxorubicin and radiation for treatment of human malignant tumors in vivo, the relationship between treatment-induced apoptosis and Ki-67 labeling index was investigated. Four human tumor xenografts (ependymoblastoma, NNE; primitive neuroectodermal tumor, YKP; small cell lung carcinoma, GLS; glioblastoma, KYG) were transplanted under the skin of thigh of the nude mice (BALB/cA JcL-nu). The mice were given a single radiation dose of 1 Gy, or doxorubicin alone intraperitoneally at a dose of 8 mg/kg. After treatment, sections of tumor specimens were prepared from paraffin-embedded tissues. Hematoxylin and eosin staining, TUNEL staining, and immunohistochemical analysis of Ki-67 were performed. In NNE, apoptotic cells appeared most frequently after treatment compared with all other tumors, and the incidence of apoptosis in the radiation-treated group was much higher than in the doxorubicintreated group. As the incidence of apoptosis in NNE increased, the Ki-67 labeling index ...

International Nuclear Information System (INIS)

Radiation hardening in austenitic stainless steels is shown to modify deformation characteristics and correlate well with an increased susceptibility to intergranular stress corrosion cracking (IGSCC). Available data on neutron-irradiated materials have been analyzed and correlations developed between fluence, yield strength and cracking susceptibility in high-temperature water environments. Large heat-to-heat differences in the critical fluence (0.2 to 2.5 x10"2"1 n/cm"2) for IGSCC are documented. In many cases, this variability is consistent with yield strength differences among irradiated materials. IGSCC correlates better to yield strength than to fluence for most heats suggesting a possible role of radiation-induced hardening and microstructure on cracking. Microstructural evolution during proton and heavy-ion irradiation has been characterized in low-carbon 304SSs. Hardening results from a dispersion of dislocation loops in the matrix which increase in ...

Energy Technology Data Exchange (ETDEWEB)

Microcapsules consisting of alginate and hyaluronic acid that can be decomposed by radiation are currently under development. In this study, the composition of the microcapsule material was optimized by changing the amounts of alginate and hyaluronic acid. Solutions of 0.025%, 0.05%, 0.1%, 0.2%, or 0.4% (wt./vol.) hyaluronic acid were mixed into a 0.2% alginate solution. To these mixtures, carboplatin (0.2 mmol) was added and the resulting material was used for the capsule preparation. The capsules were prepared by spraying the material into a CaCl{sub 2} solution (0.34 mol/l) using a microatomizer. These capsules were irradiated by a single dose of 2, 5, or 10 Gy {sup 60}Co {gamma}-ray radiation. Immediately after irradiation, the releasing of core content of microcapsule was determined, using a micro particle induced X-ray emission (PIXE) camera. The average diameter of the microcapsules was 22.3 {+-} 3.3 {mu}m, and that of the liquid core was 10.2 {+-} 4.3 {mu}m. The maximum ...

Energy Technology Data Exchange (ETDEWEB)

Background: EGFR (epidermal growth factor receptor) and VEGF (vascular endothelial growth factor) inhibitors confer clinical benefit in metastatic colorectal cancer when combined with chemotherapy. An emerging strategy to improve outcomes in rectal cancer is to integrate biologically active, targeted agents as triple therapy into chemoradiation protocols. Material and methods: cetuximab and bevacizumab have now been incorporated into phase I-II studies of preoperative chemoradiation therapy (CRT) for rectal cancer. The rationale of these combinations, early efficacy and toxicity data, and possible molecular predictors for tumor response are reviewed. Computerized bibliographic searches of Pubmed were supplemented with hand searches of reference lists and abstracts of ASCO and ASTRO meetings. Results: the combination of cetuximab and CRT can be safely applied without dose compromises of the respective treatment components. Disappointingly low rates of pathologic complete remission have ...

International Nuclear Information System (INIS)

The radiation-induced microstructural changes have been studied by cross-sectional transmission electron microscopy for single-crystal #alpha#-Al_2O_3 samples irradiated with triple ion beams (0.25 MeV H"+, 0.6 MeV He"+ and 2.4 MeV O"2"+; 'Triple (A)'), (0.33 MeV H"+, 0.45 MeV He"+ and 1.3 MeV O"+; 'Triple (B)') and three consecutive single ion beams (0.3 MeV H"+ ion followed by 0.6 MeV He"+ and then 0.8 MeV O"+ ions) at 650 C to doses in the range 0.1-8.4 dpa at the damage peak. In the specimen irradiated with Triple (A), having the same average projected range to a total peak dose of 3.7 dpa, cavities with an average diameter of 13 nm were formed between 1.2 and 1.75 #mu#m in depth causing a swelling of 0.1% at the peak, which is larger than those of the specimens irradiated with other conditions. The extent of the cavity-introduced region is some 40% smaller than observed in the damage region due to the He"+ and the O"+ ions and due to the H"+ ions in the sample ...

Energy Technology Data Exchange (ETDEWEB)

The purified integral membrane protein, band 3, from human erythrocytes was inserted into egg lecithin liposomes. The insertion of band 3 was determined from thermal transition data from the analysis of the C-H stretching region bands recorded at temperatures from 25 to -22[sup o]C. Raman spectra show that band 3 considerably broadens and lowers the thermal transition of egg lecithin liposomes, suggesting the insertion of band 3. The band 3-inserted liposomes were irradiated with gamma-rays (40 Gy) and the radiation target groups were determined by the analysis of the structural sensitive Raman bands in the 1600-1700 cm[sup -1] (amide I), 1200-1300 cm[sup -1] (amide III) and 550-1030 cm[sup -1] (side chain amino groups) regions. The radiation-sensitive groups as identified from Raman spectra in the region 550-1030 cm[sup -1] are tyrosines and cysteines. The radiation-induced changes in the secondary structure were determined from amide I and III bands. Quantitative ...

International Nuclear Information System (INIS)

Borosilicate based glass formulations have been found suitable for fixing the HLW (high level radioactive liquid waste) generated after reprocessing of the spent nuclear fuel. As the glass experiences continuous irradiation by #alpha#, #beta#a, and #gamma# radiations from the radioactive components of HLW, alteration in the glass structure may occur. Understanding of these structural evolutions of the nuclear waste glasses under irradiation is crucial to secure long term disposal and predict their behavior. In the present work, alkali based barium borosilicate glasses, having composition similar to that of Trombay Research Reactor waste glass were irradiated with high energy "1"2C beam and the radiation induced changes were monitored by micro Raman experiment. Since a "1"2C atom can be considered as a cluster of alphas, this beam was chosen to yield linear energy losses (LET) comparable to that in case of a particles. The irradiations were ...

International Nuclear Information System (INIS)

This report summarizes work performed by Argonne National Laboratory (ANL) on fatigue and environmentally assisted cracking (EAC) in light water reactors (LWRs) during the six months from October 1993 to March 1994. EAC and fatigue of piping, pressure vessels, and core components in LWRs are important concerns in operating plants and as extended reactor lifetimes are envisaged. Topics that have been investigated include (a) fatigue of low-alloy steel used in piping, steam generators, and reactor pressure vessels, (b) EAC of wrought and cast austenitic stainless steels (SSs), and (c) radiation-induced segregation and irradiation-assisted stress corrosion cracking (IASCC) of Type 304 SS after accumulation of relatively high fluence. Fatigue tests have been conducted on A302-Gr B low-alloy steel to verify whether the current predictions of modest decreases of fatigue life in simulated pressurized water reactor water are valid for high-sulfur heats that show ...

International Nuclear Information System (INIS)

The present study was designed to assess the radioprotective effects of amifostine on ovarian follicles. Three week-old female mice with or without pretreatment of amifostine were irradiated with 6.42 Gy of #gamma# -ray. Ovaries were collected 0 and 6h after irradiation. DNA fragmentation pattern and expression of genes and activity of proteins related with apoptosis were investigated by means of RT-PCR and Western blot. Proliferation of granulosa cells was reduced and incidence rate of follicular atresia was increased in ovarian follicles in #gamma# -ray irradiated mice compared to those in control or amifostine-treated group. DNA fragmentation was increased in time-dependent manner in granulosa cells of all irradiated groups. However, no difference between amifostine pre-treated group and irradiated groups was found and the expression of p53 as tumor suppressor gene and Bax as one of pro-apoptotic Bcl-2 family was increased in irradiated mice ovaries. PARP as DNA damage sensor was ...

International Nuclear Information System (INIS)

The DNA double-strand break (DSB) damage response induced by high energy charged particles on lung fibroblast cells embedded in a 3-dimensional (3-D) collagen tissue equivalents was investigated using antibodies to the DNA damage response proteins gamma-histone 2AX (#gamma#-H2AX) and phosphorylated DNA-PKcs (p-DNA-PKcs). 3-D tissue equivalents were irradiated in positions across the linear distribution of the Bragg curve profiles of 307.7 MeV/nucleon, 556.9 MeV/nucleon, or 967.0 MeV/nucleon "5"6Fe ions at a dose of 0.30 Gy. Patterns of discrete DNA damage streaks across nuclei or saturated nuclear damage were observed, with saturated nuclear damage being more predominant as samples were positioned closer to the physical Bragg peak. Quantification of the DNA damage signal intensities at each distance for each of the examined energies revealed a biological Bragg curve profile with a pattern of DNA damage intensity similar to the physical Bragg curve for the particular energy. ...

International Nuclear Information System (INIS)

Simulation irradiation experiments were carried out to investigate the formation processes and contribution to hardening of radiation-induced features in low alloy steels. Medium Cu (0.12 and 0.16%) and low Cu (0.03%) A533B steels were irradiated with 3 MeV Ni ions and 5 MeV electrons, and in KUR at 290degC. Irradiated steels were examined by three-dimensional atom probe, positron annihilation, high-resolution transmission electron microscopy and hardness measurements. Electron irradiation caused almost the same hardening as KUR irradiation in medium Cu steels under almost the same dose rate and dose conditions, whereas the formation of larger, denser and more Cu enriched clusters and smaller accumulation of single vacancies were confirmed for KUR irradiation. This indicated that cascade damage provides additional cluster nucleation sites to compensate for lower free point defect production. High dose rate Ni ion irradiation produced Mn-Ni-Si clusters and ...

International Nuclear Information System (INIS)

A conceptual framework is proposed within which the notion of risk as normally used in risk assessment (RA) could be enlarged in line with the real substance of social issues of technology policy, to help avoid RA's threatened irrelevance to social decision making. It is argued that the frequent organizational incoherence and thus the unviability of modern technology arises from 'social alienation' between the innovation-commitment phase and the implementation of the technology in society. The roles of technical elites and of particular concepts of technology in this alienation are emphasized. One of the case studies deals with 'Nuclear power - myths of scientific and organizational realism' and discusses the UK nuclear 'programme' and the Three Mile Island accident. (author).

British Library Electronic Table of Contents (United Kingdom)

Back pain from osteoporosis is commonly related to compression fractures. The patient with vertebral compression fractures additionally suffers from an ongoing risk of recurrent fractures and postural abnormalities that can result in impaired respiratory function, leading to increased risk of morbidity. Weakened back muscles, especially the back extensor group, are felt to contribute significantly to this risk. The combination of pharmacologic and nonpharmacologic interventions, through physical activity, exercise, and modalities, are potential interventions that could be used to help reduce the pain of osteoporotic compression fractures as well as potentially reducing recurrent fracture rates.

UK PubMed Central (United Kingdom)

Patients rely on their primary care physician to manage multiple, often chronic medical conditions that require prescription medications. Balancing the risk to benefit of treatments can be challenging...Full Text Available

UK PubMed Central (United Kingdom)

Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably soy. A litany of health benefits including a lowered risk of osteoporosis, heart disease, breast cancer,...Full Text Available

Science.gov (United States)

Schizophrenia and bipolar disorder share genetic risk, brain vulnerability, and clinical symptoms. The ZNF804A risk variant, rs1344706, confers susceptibility for both disorders. This study aimed to identify neural mechanisms common to both schizophrenia and bipolar disorder through this variant's potential effects on cortical thickness, white matter tract integrity, and cognitive function. Imaging, genetics, and cognitive measures were ascertained in 62 healthy adults aged between 18 and 59 years. High-resolution multimodal MRI/DTI imaging was used to measure cortical thickness and major frontotemporal and interhemispheric white matter tracts. The general linear model was used to examine the influence of the ZNF804A rs1344706 risk variant on cortical thickness, white matter tract integrity, and cognitive measures. Individuals homozygous for the risk variant ('A' allele) demonstrated reduced cortical ...