PurposeA dosimetric comparison between multiple static-field intensity-modulatedradiation therapy (IMRT), multi-arc intensity-modulated arc therapy (IMAT) and single-arc...Full Text Available
Selective estrogen receptor modulators (SERMs) represent a class with a growing number of compounds that act as either estrogen receptor agonists or antagonists in a tissue-specific manner. This article...Full Text Available
New non-collinear schemes are suggested for transverse velocity modulation of electron beams and for the generation of coherent spontaneous radiation by these transversely modulated beams. It is shown that due to the non-collinearity some orders of magnitude enhancement can be achieved for the coherent spontaneous radiation (CSR) power at both the fundamental and harmonic frequencies.
A new kind of e-beam bunching enabling the production of coherent spontaneous emission (CSE) is proposed and considered. It is shown that an e-beam in passing through an undulator will induce CSE along with incoherent spontaneous radiation on the same wavelength if the e-beam transverse velocity is modulated with a spatial period twice as long as the radiation wavelength. Such angular modulated beams can be regarded as alternatives to conventionally density modulated beams for CSE production. Requirements for e-beams are similar in both cases.
BackgroundTo compare two strategies of dynamic intensity modulatedradiation therapy (dIMRT) with 3-dimensional conformal radiation therapy (3DCRT) in the setting of hypofractionated...Full Text Available
Intensity modulated radiotherapy (IMRT) is widely used in clinical applications in developed countries, for the treatment of malignant and non-malignant diseases. This technique uses multiple radiation...Full Text Available
BackgroundTo compare the differences in dose-volume data among coplanar intensity modulated radiotherapy (IMRT), noncoplanar IMRT, and helical tomotherapy (HT) among patients with...Full Text Available
The behavior of a small power system consisting of two interconnected generators is simulated in real-time by a prototype Digital Transient Network Analyzer (TNA). The prototype Digital TNA consists of two Computational Modules and one I/O Module. The Modules communicate with each other through ribbon cables. Each Computational Module simulates one Turbo-Generator, its Transformer, its Governor, Exciter, and Power System Stabilizer Systems. The numerical integration is shared by two TMS320C30 DSPs at a step-size of 100 microseconds in real-time. The I/O module post-processes the state variables and presents selected information for analog display. The paper presents oscillograms from a test program which includes symmetry checks and behavioral checks against well known waveforms of hunting oscillations, synchronization out-of-phase torques, and subsynchronous ...
For intensity modulatedradiation treatment (IMRT) dose reconstruction, multileaf collimator (MLC) log files have been shown applicable for deriving delivered fluence maps. However, MLC log files are...Full Text Available
Prostatic neoplasms are not uniformly distributed within the prostate volume. With recent developments in three-dimensional intensity-modulated and imageguided radiation therapy, it is possible to treat...Full Text Available
In many radiotherapy clinics, geometric uncertainties in the delivery of 3D conformal radiation therapy and intensity modulatedradiation therapy of the prostate are reduced by aligning the...Full Text Available
Purpose: To evaluate the outcomes of patients with Ewing's sarcoma family of tumors (ESFT) treated with modern radiotherapy techniques with MRI along with optimal chemotherapy. Methods and Materials: The records of all 60 patients with ESFT who received radiation to the primary site between 1990 and 2004 were reviewed. All patients received chemotherapy, including vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide. Radiation was used as the sole modality for local control in 31 patients and was given either before (n = 3) or after surgical resection (n = 26) in the remainder. All patients had MRI and CT scan-based treatment planning, and 43% received intensity-modulatedradiation therapy. Radiation doses ranged from 30 Gy to 60 Gy (median, 51 Gy), and 35% received hyperfractionated radiotherapy. Results: Median age was 16 years (range, 2-40 years). Because of ...
Selection of the appropriate radiation quality is an important aspect of optimisation for every clinical imaging task in radiology, since it affects both image quality and patient dose. Spreadsheet...Full Text Available
... spontaneous radiation of amplifiers within a relatively w~de range of ... pulse widths are 20-30ns, while amplified spontaneous radiation pulse ...
In embodiments, spectroscopic monitor monitors modulated light signals to detect low levels of contaminants and other compounds in the presence of background interference. The monitor uses a spectrometer that includes a transmissive modulator capable of causing different frequency ranges to move onto and off of the detector. The different ranges can include those with the desired signal and those selected to subtract background contributions from those with the desired signal. Embodiments of the system are particularly useful for monitoring metal concentrations in combustion effluent.
Implementation of quantum logical gates for multilevel systems is demonstrated through decoherence control under the quantum adiabatic method using simple phase modulated laser pulses. We make use of selective population inversion and Hamiltonian evolution with time to achieve such goals robustly instead of the standard unitary transformation language. (letter to the editor)
Allen's Rule documents a century-old biological observation that strong positive correlations exist among latitude, ambient temperature, and limb length in mammals. Although genetic selection for thermoregulatory...Full Text Available
BackgroundVisual neurons respond essentially to luminance variations occurring within their receptive fields. In primary visual cortex, each neuron is a filter for stimulus features...Full Text Available
BackgroundTo evaluate the performance of three different advanced treatment techniques on a group of complex paediatric cancer cases.MethodsCT...Full Text Available
Women experience a decline in estrogen and androgen levels after natural or surgically induced menopause, effects that are associated with a loss of sexual desire and bone mineral density. Studies in...Full Text Available
Tamoxifen (TAM) is a selective estrogen receptor modulator widely used in the prevention and treatment of breast cancer. A major mode of metabolism of the major active metabolites of TAM, 4-OH-TAM...Full Text Available
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. However, the role of the AHR...Full Text Available
In this experiments, we established long-termed culture methods of bone marrow stromal cells for proliferation and differentiation of stem cells. And we selected some extracts which support maximal proliferation of stromal cells with this method. We conformed the synergic effects of herbal mixture extracts for stromal cell growth. The proliferation of stromal cells was increased rather by the addition of mixture extracts than by addition of single strain extract. In the previous and cooperative experiments, we selected complex extracts (Him-I, Him-II) which increased the number of nonadherent mononuclear cells. Different cytokine expression patterns were observed stromal cells cultured in the presence or absence of mixture extracts which support differentiation of nonadherent cells. Some fractions of Him-I and Him-II increased the proliferation of bone marrow cells irradiated {gamma}-ray(4Gray). Stimulation of macrophage cell line with herval ...
Purpose:To investigate the clinical usage of dose verification of Helical Tomotherapy plans by using 2D-array ion chambers, and to develop an efficient way to validate the dose delivered...Full Text Available
The problem of optimizing a horn radiator of electromagnetic waves for the reflection coefficient and the coefficient of transformation of the fundamental mode into higher order modes is solved. Optimization is performed by means of selecting a combined shape of the radiator generatrices.
Dose calculations for radiation arc therapy are traditionally performed by approximating continuous delivery arcs with multiple static beams. For 3D conformal arc treatments, the shape and weight variation per degree is usually small enough to allow arcs to be approximated by static beams separated by 5"0-10"0. But with intensity-modulated arc therapy (IMAT), the variation in shape and dose per degree can be large enough to require a finer angular spacing. With the increase in the number of beams, a deterministic dose calculation method, such as collapsed-cone convolution/superposition, will require proportionally longer computational times, which may not be practical clinically. We propose to use a homegrown Monte Carlo kernel-superposition technique (MCKS) to compute doses for rotational delivery. The IMAT plans were generated with 36 static beams, which were subsequently interpolated into finer angular intervals for dose calculation to mimic ...
High energy muon colliders, such as the TeV-scale conceptual designs now being considered, are found to produce enough high energy neutrinos to constitute a potentially serious off-site radiation hazard in the neighbourhood of the accelerator site. A general characterization of this radiation hazard is given, followed by an order-of-magnitude calculation for the off-site annual radiation dose and a discussion of accelerator design and site selection strategies to minimize the radiation hazard.
In this experiments, we established long-termed culture methods of bone marrow stromal cells for proliferation and differentiation of stem cells. And we selected some extracts which support maximal proliferation of stromal cells with this method. We conformed the synergic effects of herval mixture extracts for stromal cell growth. The proliferation of stromal cells was increased rather by the addition of mixture extracts than by addition of single strain extract. In the previous and cooperative experiments, we selected complex extracts which increased the number of nonadherent mononuclear cells. Different cytokine expression patterns were observed stromal cells cultured in the presence or absence of mixture extracts which support differentiation of nonadherent cells. Stimulation of macrophage cell line with herval extracts with the treatments of recombinant interferon-{gamma} resulted in increased nitric oxide synthesis in a dose-dependent ...
Monochromator stabilization (MOSTAB) is a feedback control system to stabilize an x-ray beam of synchrotron radiation. It applies a feedback voltage to a piezo electric transducer attached to a double-crystal monochromator. We developed MOSTAB modules and examined their performances using SPring-8 beamlines. The x-ray beam position stabilization using MOSTAB was realized simultaneously with the x-ray beam intensity stabilization. As an example of its application, we performed EXAFS measurement with MOSTAB. (author)
The proton therapy gives an irradiation adapted to the shape and the depth of tumors ( eyes, head and neck) with a millimetric, even sub millimetric precision for the ophthalmological tumors. It is equally an excellent tool for the pediatrics tumors. For numerous treatments in France the proton therapy is associated to the photons treatments (x radiation). however, others physical treatments could modulate the medical offer, such thermal therapy or treatments by ultrasonic waves. (N.C.)
The incidence of hilar cholangiocarcinoma is very rare worldwide. Radical resection is the only prognostic factor for long survival in patients with hilar cholangiocarcinoma. Postoperative radiation therapy can improve local control and survival rates for patients with palliative resection, but it remains controversial in patients with radical resection. Biliary drainage can effectively release bile duct obstruction for the majority of patients with locally advanced disease, and may even prolong survival when combined with radiation therapy. Radiation therapy includes extrernal beam therapy alone, external beam therapy with intraluminal brachytheapy and new radiation technique, such as three dimentional conformal therapy and intensity modulatedradiation therapy. The propective randomized clinical study is needed for further investigation in the role of combined ...
This user's guide describes BNW-III, a computer code developed by the Pacific Northwest Laboratory (PNL) as part of the Dry Cooling Enhancement Program sponsored by the US Department of Energy (DOE). The BNW-III code models a modular dry/wet cooling system for a nuclear or fossil fuel power plant. The purpose of this guide is to give the code user a brief description of what the BNW-III code is and how to use it. It describes the cooling system being modeled and the various models used. A detailed description of code input and code output is also included. The BNW-III code was developed to analyze a specific cooling system layout. However, there is a large degree of freedom in the type of cooling modules that can be selected and in the performance of those modules. The costs of the modules are input to the code, giving the user a great deal of flexibility.
The authors present the emitter efficiency results for the thin film 25 percent Ho YAG (Yttrium Aluminum Garnet, Y3Al5O12) selective emitter from 1000 to 1700 K with a platinum substrate. Spectral emittance and emissive power measurements were made (1.2 less than lambda less than 3.2 microns) and used to calculate the radiative efficiency. The radiative efficiency and power density of rare earth doped selective emitters are strongly dependent on temperature and experimental results indicate an optimum temperature (1650 K for Ho YAG) for thermophotovoltaic (TPV) applications.
This paper presents an analysis of the performance of a selective emitter using small particles of rare earth compounds stable at high temperatures in a low emittance inert gas stream. An expression for the spectral emissive power excluding radiation scattering was derived to include the radiation in the emission band, produced by electronic transitions of the rare earth ion, and the continuum radiation outside the emission band produced by the rare earth host. Preliminary results suggest that a selective emitter based on suspended rare earth oxide particles will have high efficiency and merits further experimental investigation. {copyright} {ital 1996 American Institute of Physics.}
A brief overview if provided of selected reports presented at the International Symposium on Molecular Mechanisms of Radiation- and Chemical Carcinogen-Induced Cell Transformation held at Mackinac Island, Michigan on September 19-23, 1993.
A method for recycling laser flashlamp radiation in selected wavelength ranges to decrease thermal loading of the solid state laser matrix while substantially maintaining the pumping efficiency of the flashlamp.
Prostate cancer can be successfully treated using dynamic adaptive external beam radiation techniques along with interstitial brachytherapy to deliver curative therapies with low urinary, rectal and erectile function morbidity. Through the use of sophisticated, state-of-the art radiographic imaging for staging and treatment planning, a precise, individual design for treatment is accomplished. Symptom management and patient education are of paramount importance and are integrated throughout the treatment process.
In searching modulators of immunity and hematopoiesis among natural products, being used as foods, six herbs exhibited lymphocyte proliferation in vitro, and six exhibited augmentation of hematopoietic cell growth. The combined treatments showed synergistic effects of lymphocyte proliferation and of hematopoietic cell growth. On the other hand, we found four effective oriental medicinal prescriptions, used as energy tonic or blood-building decoctions, for survival and regeneration of hematopoietic cells and for protection of stem cells of intestinal crypt in irradiated mice. On the basis of these results, extracts from combinations of herbs were made in expectation of higher effects in the three respects. In immuno modulation activity by the two combinations of herbs was confirmed in mice. In culture of bone narrow cells, growth improvement of non-adherent precursor and induction of cytokine expression by herb mixture extracts were observed. In ...
Lifetime of minority charae carriers in the Si and Ge p-n unctions has been measured by pulse method of conductivity modulation of base. Its dependence on the X-ray radiation dose has been investigated. Dependence of current transmission coefficients on the dose has been measured and their sharp decrease at low doses and the following saturation at high doses have been observed. Linear dependence of lifetime on X-ray radiation dose has been obtained. Resulting from the comparison of regularities of the change of lifetime due to current characteristics, it has been shown that X-ray radiation leads to the formation of the surface defects, influencing the change of current characteristics as well as to stationary structural defects, causing the decrease of lifetime of the charge carriers with the increase of X-ray radiation dose.
Silicon sensors have about ten times improved radiation hardness around 130 K temperature, compared with the state-of-art sensors close to room temperature. This is based on the Lazarus effect studied by the RD39 Collaboration of CERN. Other benefits of low temperatures will also be discussed. We shall describe the conceptual design of low-mass detector modules cooled using two-phase flow of argon in miniature cooling pipes integrated in the module structure between the sensors and the readout hybrid circuit. The main engineering features of the cooling system and mechanical support structures are discussed, as well as the benefits arising from the operation of the tracker under cryogenic vacuum. 4 Refs.
A consideration is given to the problem of selecting optimized methods of radionuclide radiation registration during the control of the objects with essential changes in thickness. Adequate model of information signal formation is developed and analyzed for the case of the existence of an inertial link of the system with the dead time of a noncontinued type. The boundary values of radiation thickness and radiation flux intensity that divide the priority of using either digital or analog registration modes are revealed. The method is found for the full correction of a systematic error of flux intensity measurement because of the dead time of the apparatus. To control the objects with essential variation of thickness the method of selective measurement of radiation intensity is proposed
BC Hydro recently conducted a demonstration test of a bearing condition monitor. The test, at the 529-MW Kootenay Canal project, proved the ability of the monitor to detect machine condition faults. The capability to detect changing conditions during normal operation of hydroelectric machines gives hydro plant owners the opportunity to anticipate needed maintenance and ultimately to reduce the number of equipment failures. BC Hydro intends to install bearing condition monitors, as well as windings monitors, brushgear monitors, environmental monitors, and other selected systems in as many as 46 of its hydro generators. BC Hydro analyzed forced outages between 1985 and 1989 in its hydro system to identify which parts of a generating unit resulted in the highest number of hours of outage. From there, the utility has formulated a concept for a machine condition monitoring system. To keep the system cost effective, it will be developed in modules. ...
A new leaf-sequencing approach has been developed that is designed to reduce the number of required beam segments for step-and-shoot intensity modulatedradiation therapy (IMRT). This approach to leaf sequencing is called continuous-intensity-map-optimization (CIMO). Using a simulated annealing algorithm, CIMO seeks to minimize differences between the optimized and sequenced intensity maps. Two distinguishing features of the CIMO algorithm are (1) CIMO does not require that each optimized intensity map be clustered into discrete levels and (2) CIMO is not rule-based but rather simultaneously optimizes both the aperture shapes and weights. To test the CIMO algorithm, ten IMRT patient cases were selected (four head-and-neck, two pancreas, two prostate, one brain, and one pelvis). For each case, the optimized intensity maps were extracted from the Pinnacle"3 treatment planning system. The CIMO algorithm was applied, and the ...
A testing program has been conducted by the Westinghouse Hanford Company to confirm the baseline waste form selection for use in Waste Receiving and Processing (WRAP) Module 2A. WRAP Module 2A will provide treatment required to properly dispose of containerized contact-handled, mixed low-level waste at the US Department of Energy Hanford Site in south-central Washington State. Solidification/stabilization has been chosen as the appropriate treatment for this waste. This work is intended to test cement-based, thermosetting polymer, and thermoplastic polymer solidification media to substantiate the technology approach for WRAP Module 2A. Screening tests were performed using the major chemical constituent of each waste type to measure the gross compatibility with the immobilization media and to determine formulations for more detailed testing. Surrogate materials representing each of the eight waste types ...
Standard radiation monitoring has been conducted at Sendai nuclear power station for the purpose of estimation of 'source activity' during refueling outage and evaluation of countermeasures to reduce dose rate. Selected objects of the monitoring are radiation dose rate at maintenance area, radiation field at each equipment and piping, coolant chemistry and plant operation condition. Monitored data indicates that 'source activity' variation can be estimated to some extent using influential factors, and that evaluation of change of loose crud activity, which is presumed to be represented by the dose rate at letdown heat exchanger, is necessary to further explain change in radiation field at main work area. (author).
The effect of abatacept, a selective T-cell co-stimulation modulator, on vaccination has not been previously investigated. In this open-label, single-dose, randomized, parallel-group, controlled study,...Full Text Available
Spider venoms provide a highly valuable source of peptide toxins that act on a wide diversity of membrane-bound receptors and ion channels. In this work, we report isolation, biochemical analysis, and...Full Text Available
In radiation processing of food, the product often has to be prepackaged to prevent microbial recontamination during and after irradiation. The packaging material is exposed to radiation during radiation processing and radiation stability is a key consideration in the selection of packaging materials. The effects of ionizing radiation on many food packaging materials at the dose levels recommended for food precessing can be minimized by selecting appropriate radiation resistant materials. It is important to select materials in which chemicals formed as a result of the radiation treatment do not migrate and interact with the food, affecting its organoleptic and toxicological aspects. It is also important to select materials in which the physical properties are ...
Endothelial dysfunction and increased platelet aggregation may be involved in the pathogenesis of normal tissue radiation toxicity. This study assessed clopidogrel, an inhibitor of ADP-induced platelet aggregation, as a modulator of intestinal radiation injury (radiation enteropathy). Rat small intestine was exposed to 21 Gy X-radiation. Clopidogrel (20 mg/kg/day) or vehicle was administered from 2 days before to 10 days after irradiation. Structural radiation injury, neutrophil infiltration, smooth muscle cell proliferation, collagen content, and TGF-beta1 expression were assessed 2 weeks (early phase) and 26 weeks (delayed phase) after irradiation, using quantitative histology and immunohistochemistry, morphometry, and real-time fluorogenic probe RT-PCR. Irradiated intestine exhibited significant histopathologic injury, reduced mucosal surface area, vascular ...
Full text: Radiotherapy treatment planning (RTP) relies heavily on medical imaging. Until recently, the most important planning tool was the treatment simulator. The kilovoltage radiographic capabilities in a treatment simulator enabled the boundaries of treatment fields to be visualized with respect to bony anatomic landmarks. Perhaps the most important advance in treatment planning in recent years is the ability to visualize the passage of the beams with respect to a more accurate geometrical representation of the tumor and other soft tissue structures. This 'virtual simulation' uses a computer-based representation of a patient to determine the extent of the disease and the location of radiation sensitive normal tissue. Computer tomographic (CT) imaging produces a high-resolution three-dimensional representation of anatomy that can be correlated with other image sets such as magnetic resonance images (MRI) of function. Positron emission tomographic (PET) imaging ...
This document is a progress report to the USDOE Atmospheric Radiation and Measurement Program (ARM). The overall project goal is to relate subgrid-cumulus-cloud formation, coverage, and population characteristics to statistical properties of surface-layer air, which in turn are modulated by heterogeneous land-usage within GCM-grid-box-size regions. The motivation is to improve the understanding and prediction of climate change by more accurately describing radiative and cloud processes.
The long-term survival of certain patients after treatment with radiation or chemotherapeutic agents has allowed the realization that agents that effectively control cancer in the human subject may also possess an oncogenic potential, resulting in secondary malignancies in a significant proportion of surviving patients. A quantitative assessment of the oncogenic effects of these agents at a cellular level is important, as is information on conditions and agents that may effectively alter the development of the neoplastic state. Cell culture systems where the neoplastic transformation of cells can be scored after exposure to carcinogens offer powerful tools for evaluating the oncogenic potential of radiation and chemotherapeutic agents.
Only a small number of radiation accidents in the United States have been severe enough to result in multi-organ failure (MOF). Medical details of selected medical misadministration and criticality cases are reviewed, with an emphasis on pathophysiology. The four criticality cases are particularly relevant for analysis of MOF, since medical treatment was supportive and did not appreciably alter the clinical evolution of radiation injury. PMID:15975871
The philosophy of work management in radiation protection puts emphasis on the following up and management of overall process from work selection, planning, preparation, implementation till experience feedback, and overall optimization of production and safety management. This paper reports practices and experiences of Daya Bay nuclear power plant in the implementation of the philosophy during operational radiation protection through the practical examples
To determine if barbiturates would protect brain at high doses of radiation, survival rates in rats that received whole-brain x-irradiation during pentobarbital- or lidocaine-induced anesthesia were compared with those of control animals that received no medication and of animals anesthetized with ketamine. The animals were shielded so that respiratory and digestive tissues would not be damaged by the radiation. Survival rates in rats that received whole-brain irradiation as a single 7500-rad dose under pentobarbital- or lidocaine-induced anesthesia was increased from between from 0% and 20% to between 45% and 69% over the 40 days of observation compared with the other two groups (p less than 0.007). Ketamine anesthesia provided no protection. There were no notable differential effects upon non-neural tissues, suggesting that pentobarbital afforded protection through modulation of ambient neural activity during ...
Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitaive are also the least relevant in terms of human carcinogenesis and human risk estimation. The development of cell culture systems has made it possible to assess at the cellular level the oncogenic potential of a variety of chemical, physical and viral agents. Cell culture systems afford the opportunity to identify factors and conditions that may prevent or enhance cellular transformation by radiation and chemicals. Permissive and protective factors in radiation-induced transformation include thyroid hormone and the tumor promoter TPA that increase the transformation incidence for a given dose of radiation, and retinoids, selenium, vitamin E, and ...
Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitaive are also the least relevant in terms of human carcinogenesis and human risk estimation. The development of cell culture systems has made it possible to assess at the cellular level the oncogenic potential of a variety of chemical, physical and viral agents. Cell culture systems afford the opportunity to identify factors and conditions that may prevent or enhance cellular transformation by radiation and chemicals. Permissive and protective factors in radiation-induced transformation include thyroid hormone and the tumor promoter TPA that increase the transformation incidence for a given dose of radiation, and retinoids, selenium, vitamin E, and ...
This book presents the basic ideas of the physics of non-gravitational perturbations and the mathematics required to compute their orbital effects. It conveys the relevance of the different problems that must be solved to achieve a given level of accuracy in orbit determination and in recovery of geophysically significant parameters. Selected Contents are: Orders of Magnitude of the Perturbing Forces, Tides and Apparent Forces, Tools from Celestial Mechanics, Solar Radiation Pressure-Direct Effects: Satellite-Solar Radiation Interaction, Long-Term Effects on Semi-Major Axis, Radiation Pressure-Indirect Effects: Earth-Reflected Radiation Pressure, Anisotropic Thermal Emission, Drag: Orbital Perturbations by a Drag-Like Force, and Charged Particle Drag.
Megavoltage photon intensity-modulatedradiation therapy (IMRT) is typically used in the treatment of prostate cancer at our institution. Approximately 1% to 2% of patients with prostate cancer have hip prostheses. The presence of the prosthesis usually complicates the planning process because of dose perturbation around the prosthesis, radiation attenuation through the prosthesis, and the introduction of computed tomography artifacts in the planning volume. In addition, hip prostheses are typically made of materials of high atomic number, which add uncertainty to the dosimetry of the prostate and critical organs in the planning volume. When the prosthesis is bilateral, treatment planning is further complicated because only a limited number of beam angles can be used to avoid the prostheses. In this case study, we will report the observed advantages of using noncoplanar beams in the delivery of IMRT to a prostate cancer ...
The atomic explosions in Hiroshima and Nagasaki made the name radiation itself become a nightmare. Notwithstanding this, radiation continued to serve the mankind specially in diagnosis of several human diseases and in the treatment of intractable malignancies. With their latest research tools biologists have now shown a significant shift in the earlier paradigm; even the concept that radiation initiates cancer appears to be no longer tenable. On the contrary, selectiveradiation doses inhibit growth of cancer cells and radiation in combination with many chemotherapeutic drugs, radiosensitizing chemicals and/or hyperthermia, is emerging as a new modality for cancer treatment which offers high therapeutic advantages. In addition, the deleterious effects of radiation can now be strategically counter poised by the use of many drugs and ...
Reported in this paper are the theoretical and experimental studies, with regard to the effects of radiation between walls, conducted for the improvement of heat transfer characteristics of the circular duct in high temperature heat exchangers that operate through the medium of non-radiating gases at around 1,000"0C. To study the fundamental performance of the heat transfer augmentation, the experiment was carried out using a double tube at temperatures up to 900"0C. The outer tube in a double tube was selectively heated so as to give a uniform heat flux selected of 6.5 x 10"3 and 4.6 x 10"4 kcal/m"2.h, while the inner tube was used as a radiating surface to impart the radiation heat transmitted from the outer tube. Selectively preheated air was caused to flow in an annular passage at an inlet temperature selected within ...
For the step-and-shoot intensity-modulatedradiation therapy (IMRT) technique, the combination of high dose rate, multiple beam segments and low dose per segment can lead to significant differences between the planned dose and the dose delivered to the patient. In this technique, a dose delivery inaccuracy known as the 'overshoot' effect is caused by the dose servo control system. This typically occurs in the first and last beam segments and causes an over- and underdose, respectively. Some dose positional error in the segment sequence is also possible there. Commercial ionization chambers (RK-type) and radiographic Kodak films were used for the measurements. The reported results were obtained using the Pinnacle{sup 3}-V6.2 treatment planning system and a Varian Clinac 21 EX linear accelerator equipped with a 120-leaf Millennium MLC. The dose inaccuracy measurements were based on the comparison of the dose and profiles for ...
Central nervous system (CNS) development, homeostasis, stress responses, and plasticity are all mediated by epigenetic mechanisms that modulate gene expression and promote selective deployment of functional gene networks in response to complex profiles of interoceptive and environmental signals. Thus, not surprisingly, disruptions of these epigenetic processes are implicated in the pathogenesis of a spectrum of neurological and psychiatric diseases. Epigenetic mechanisms involve chromatin remodeling by relatively generic complexes that catalyze DNA methylation and various types of histone modifications. There is increasing evidence that these complexes are directed to their sites of action by long non-protein-coding RNAs (lncRNAs), of which there are tens if not hundreds of thousands speci...
Recent advances in steering algorithms have made it possible to accurately control electron beam position in storage rings, implement fast and slow feedback systems, and in some cases detect hardware errors. In practice, however, the program operator would like to reduce the overhead of selecting variables and constraints and to easily view the data. To simplify the process, we constructed an interactive orbit control program in MATLAB [1]. The program modules are easily adapted to new algorithms or beam lines. This paper describes the program functionality and architecture.
Recently it was demonstrated that long-lived quantum coherence exists during excitation energy transport in photosynthesis. It is a valid question up to which length, time and mass scales quantum coherence may extend, how one may detect this coherence and what, if any, role it plays in the dynamics of the system. Here we suggest that the selectivity filter of ion channels may exhibit quantum coherence, which might be relevant for the process of ion selectivity and conduction. We show that quantum resonances could provide an alternative approach to ultrafast two-dimensional (2D) spectroscopy to probe these quantum coherences. We demonstrate that the emergence of resonances in the conduction of ion channels that are modulated periodically by time-dependent external electric fields can serve as signatures of quantum coherence in such a system. Assessments of experimental feasibility and specific paths towards the experimental ...
E-35 reported the specific air flow analysis program using a CFSV model (including a human body model) to develop a high-accuracy evaluation simulator for heterogeneous thermal environment based on human thermal physiological conditions. E-36 reported development of the radiation heat transfer analysis module by using a numerical integral method to calculate shape factors. Radiation heat transfer characteristics every body part were clarified quantitatively by this module. E-37 reported the results on continuous measurement of physiological conditions and thermal environment factors every monitor under controlled indoor thermal environment, to collect measurement data necessary for improving the accuracy of a prediction program for human body temperatures. E-38 reported the study result on physiological reaction and subjective evaluation through an examinee experiment in a blood controlled region, to ...
Objective The aim of this study was to analyze the clinical results of our adaptive radiation therapy scheme of a two-step intensity-modulated radiotherapy (IMRT) method for nasopharyngeal cancer (NPC) at Kinki University Hospital. Methods Between 2000 and 2007, 35 patients with Stage I-IVB NPC treated by IMRT were included. For all patients, treatment-planning computed tomography was done twice before and during IMRT to a total dose of 60-70 Gy/28-35 fractions (median 68 Gy). Chemotherapy (cisplatin 80 mg/m2/3 weeks x 1-3 courses) was given concurrently with IMRT for 31 patients. Results The 3- and 5-year overall survival rates for the 31 patients treated with concurrent chemotherapy were 88% and 83%, respectively. The 3- and 5-year loco-regional control rates for the 31 patients were 93%...
This paper reports the study results on the standard weather data necessary for simulation of PV power generation systems in fiscal 1994. In the study on the selection criterion of the standard weather data from the viewpoint of PV power generation systems, three typical years are used; a year with average solar radiation, and two years with extremely less and more solar radiation for safe simulation. The standard weather data are arranged for output calculation of PV power generation systems by selecting the most typical year based on long-term observation data. The data to be arranged are as follows; total, direct and scattered solar radiations incident upon a horizontal surface, solar radiation upon a slope surface, sunshine duration, air temperature, wind direction, wind velocity, amount of precipitation, and snow depth. For arrangement of the nationwide ...
The principle is described of a method using low-activity emitters as the primary radiation source for analysis. The selection of the radiation source and the detection methods including the assessment of the applicability of various radiation detectors are discussed. The benefits and the constraints of the method are considered. Practical examples are presented showing the application possibilities of the method for testing the thickness of bearing layers, piston ring coats, lead layers, etc. The possibility is shown of applying the rapid test for the composition of tungsten and chromium alloyed metal materials in testing complex systems. (J.K.).
An array of sonic transducers, useful for medical ultrasonic imaging, has individual sections thereof separately coupled for forming separate beams of sonic energy which converge, respectively, to separate foci along a common axis of the beams. The ratio of the diameter of the radiating aperture of the array relative to a wavelength of the sonic energy is chosen to provide a moderate degree of focusing so that the depth of field at one focus blends with the depth of field of the next focus. Thereby, there is formed a continuous region of substantially uniform intensity of sonic radiation along the common beam axis. Circuitry is provided for selecting one or more specific foci dependent on the bounds of a selected region to be insonified. Upon reception of sonic energy, circuitry is provided for selecting one or more specific foci as a function of the time of travel of an echo from a ...
Endothelial dysfunction is involved in radiation responses in many normal tissues, including intestine. Endothelium-directed interventions ameliorate intestinal radiation injury (radiation enteropathy) in animal models, and anecdotal reports also suggest a beneficial effect of heparin. This study assessed low molecular weight heparin as an intestinal radiation response modifier. Rats underwent localized small bowel irradiation. Groups of rats were treated with saline, nadroparin (3 mg/kg/d), or a non-anticoagulant heparin (SR80258, 3 mg/kg/d), from 3 days before to 2 weeks after irradiation. The intestinal radiation response was assessed 2 weeks and 6 weeks after irradiation using quantitative histology; morphometry, and cellular and molecular end-points. Compared to vehicle-treated controls, nadroparin significantly exacerbated structural radiation injury, ...
This report documents a one-dimensional numerical model, SAMFT1D, developed to simulate single-phase and multiphase fluid flow and solute transport in variably saturated porous media. The formulation of the governing equations and the numerical procedures used in the code for single-phase and multiphase flow and transport are presented. The code is constructed to handle single-phase as well as two or three-phase flow conditions using two integrated sets of computational modules. The fully implicit scheme is used in the code for both single-phase and multiphase flow simulations. Either the Crank-Nicholson scheme or the fully implicit scheme may be used in the transport simulation. The single-phase modules employ the Galerkin and upstream weighted residual finite element techniques to model flow and transport of water (aqueous phase) containing dissolved single-species contaminants concurrently or sequentially, and include the treatment of ...
Sandia is a national security laboratory operated for the U.S. department of Energy by the Sandia Corporation, a Lockheed Martin Company. Sandia designs all non-nuclear components for the nation's nuclear weapons, performs a wide variety of energy research and development projects, and works on assignments that respond to national security threats - both military and economic. They encourage and seek partnerships with appropriate U.S. industry and government groups to collaborate on emerging technologies that support their mission. Today, Sandia has two primary facilities, one in Albuquerque, New Mexico, and one in Livermore, California. They employ about 7,600 people and manage about $1.4 billion of work per year. In 1995, a decision was made to move from their in-house developed systems to commercial software. This decision was driven partly by Y2K compliance issues associated with the existing operating system and support environment. Peoplesoft was ...
A method, system and a radiation detector system for use therein are provided for determining the depth distribution of radiation-emitting material distributed in a source medium, such as a contaminated field, without the need to take samples, such as extensive soil samples, to determine the depth distribution. The system includes a portable detector assembly with an x-ray or gamma-ray detector having a detector axis for detecting the emitted radiation. The radiation may be naturally-emitted by the material, such as gamma-ray-emitting radionuclides, or emitted when the material is struck by other radiation. The assembly also includes a hollow collimator in which the detector is positioned. The collimator causes the emitted radiation to bend toward the detector as rays parallel to the detector axis of the detector. The collimator may be a hollow cylinder ...
Radiation damage of the final optical components in an Inertial Confinement Fusion (ICF) reactor is a crucial issue for development of a laser-fusion reactor. To some extent, this problem will be encountered in the National Ignition Facility (NIF), but there, the integrated radiation dose will be considerably less than that encountered in a future reactor. This extremely harsh radiation environment necessitates shielding the ICF optics from direct neutron and x-ray bombardment. Several approaches have been suggested, such as the use of grazing incidence metal mirrors or fused silica wedge deflectors. While metal mirrors can withstand a larger radiation dose, their focusing qualities pose problems. Therefore wedge deflectors, originally suggested by Lawrence Livermore National Laboratory (LLNL) staff, represent a promising alternative. Radiation hardening of the fused silica ...
A system is claimed for multiplexing or demultiplexing pulsed laser radiation having an acousto-optical device which is electrically controlled to switch a common path of high pulse rate laser radiation between a plurality of spatially distinct paths for relatively lower pulse rate laser radiation at which the pulses are sequenced according to a predetermined time pattern. The acousto-optical element typically includes a Bragg cell which is electrically driven by a set of distinct frequencies, causing deflection of radiation passing therethrough at a predetermined set of angles whereby pulsed radiation on a single path may be distributed onto the plural separate paths or radiation on plural separate paths of time-sequenced pulses of radiation can be combined into a single path of augmented pulse rate. The control of the acousto-optical ...
An analytical method was proposed for calculating radiative fluxes incident on a planar circular detector from a volume multiple point chemi- or bio-luminescent source inside a coaxial cylindrical reactor. The method was designed for a cylindrical reactor when the surface reflections were neglected and when chemi- or bio-luminescence reaches a detector embedded in the same homogeneous optical medium as the point emitters of the volume multiple point source model. The radiative fluxes from arbitrarily distributed point emitters were expressed by one generalized quadruple-integral formula. Then some double- and single-integral formulas were obtained for calculating radiative fluxes from identically radiating point emitters uniformly distributed within the reactor. Selected results were compu...
The synthesis and structure-activity relationship analysis of a novel class of amide-based biaryl NR2B-selective NMDA receptor antagonists are presented. Some of the studied compounds are potent, selective, non-competitive, and voltage-independent antagonists of NR2B-containing NMDA receptors. Like the founding member of this class of antagonists (ifenprodil), several interesting compounds of the series bind to the amino terminal domain of the NR2B subunit to inhibit function. Analogue potency is modulated by linker length, flexibility, and hydrogen bonding opportunities. However, unlike previously described classes of NR2B-selective NMDA antagonists that exhibit off-target activity at a variety of monoamine receptors, the compounds described herein show much diminished effects against the...
A novel compact CT-guided intensity modulated proton radiotherapy (IMPT) system is described. The system is being designed to deliver fast IMPT so that larger target volumes and motion management can be accomplished. The system will be ideal for large and complex target volumes in young patients. The basis of the design is the dielectric wall accelerator (DWA) system being developed at the Lawrence Livermore National Laboratory (LLNL). The DWA uses fast switched high voltage transmission lines to generate pulsed electric fields on the inside of a high gradient insulating (HGI) acceleration tube. High electric field gradients are achieved by the use of alternating insulators and conductors and short pulse times. The system will produce individual pulses that can be varied in intensity, energy and spot width. The IMPT planning system will optimize delivery characteristics. The system will be capable of being sited in a conventional linac vault and provide intensity ...
Radiation exposure control is one of the most important aspects in any nuclear facility . It encompasses continuous monitoring of the various areas of the facility to detect any increase in the radiation level and/or the air activity level beyond preset limits and alarm the O and M personnel working in these areas. Detection and measurement of radiation level and the air activity level is carried out by a number of monitors installed in the areas. These monitors include Area Gamma Monitors, Continuous Air Monitors, Pu-In-Air Monitors, Criticality Monitors etc. Traditionally, these measurements are displayed and recorded on a Central Radiation Protection Console(CRPC), which is located in the central control room of the facility. This methodology suffers from the shortcoming that any worker required to enter a work area will have to inquire about the radiation status of the area ...
The aim of this study was to evaluate the differences in accuracy of dose calculation between 3 commonly used algorithms, the Pencil Beam algorithm (PB), the Anisotropic Analytical Algorithm (AAA), and the Collapsed Cone Convolution Superposition (CCCS) for intensity-modulatedradiation therapy (IMRT). The 2D dose distributions obtained with the 3 algorithms were compared on each CT slice pixel by pixel, using the MATLAB code (The MathWorks, Natick, MA) and the agreement was assessed with the ? function. The effect of the differences on dose-volume histograms (DVHs), tumor control, and normal tissue complication probability (TCP and NTCP) were also evaluated, and its significance was quantified by using a nonparametric test. In general PB generates regions of over-dosage both in the lung and in the tumor area. These differences are not always in DVH of the lung, although the Wilcoxon test indicated significant differences in 2 of 4 patients. ...
Background: the authors report on the conception and first clinical application of a donut-shaped high-dose configuration for proton therapy (PT). This approach allows one to intensify target volume dose coverage for targets encompassing a critical, dose-limiting structure - like here, the cauda equina -, whilst delivering minimal dose to other healthy structures surrounding the target, thereby reducing the integral dose. Methods and results: intensity-modulated PT methods (IMPT) for spot scanning were applied to create and deliver a donut-shaped high-dose configuration with protons, allowing treating > 75% of the target with at least 95% of the prescribed dose of 72.8 CGE, whilst restricting dose to the cauda equina to 60-65 CGE. Integral dose was lower by a factor of 3.3 as compared to intensity-modulated radiotherapy with photons (IMXT). Conclusion: IMPT and spot scanning technology allow a potentially clinically useful approach which ...
Background: the authors report on the conception and first clinical application of a donut-shaped high-dose configuration for proton therapy (PT). This approach allows one to intensify target volume dose coverage for targets encompassing a critical, dose-limiting structure - like here, the cauda equina -, whilst delivering minimal dose to other healthy structures surrounding the target, thereby reducing the integral dose. Methods and results: intensity-modulated PT methods (IMPT) for spot scanning were applied to create and deliver a donut-shaped high-dose configuration with protons, allowing treating > 75% of the target with at least 95% of the prescribed dose of 72.8 CGE, whilst restricting dose to the cauda equina to 60-65 CGE. Integral dose was lower by a factor of 3.3 as compared to intensity-modulated radiotherapy with photons (IMXT). Conclusion: IMPT and spot scanning technology allow a potentially clinically useful approach which is ...
A paraboloidal dish solar thermal power plant produces electrical energy by a two-step conversion process. The collector subsystem is composed of a two-axis tracking paraboloidal concentrator and a cavity receiver. The concentrator focuses intercepted sunlight (direct, normal insolation) into a cavity receiver whose aperture encircles the focal point of the concentrator. At the internal wall of the receiver the electromagnetic radiation is converted to thermal energy. A heat engine/generator assembly, which is mounted directly behind th receiver, then converts the thermal energy captured by the receiver to electricity. Developmental activity has been concentrated on relatively small power modules which employ 11- to 12-m-diam dishes to generate nominal power levels of approximately 20 kW. A comparison of advanced heat engines for use on the dish power module is presented in terms of the performance potential of each engine ...
The genetically significant dose (GSD) is an index variable which exclusively allows to describe the genetic risk in the progeny of a population due to the application of ionizing radiation and radioactive substances in one part of this population. It may result in wrong interpretation of population exposure at increasing incidence of examinations in a population involving ionizing radiation and radioactive drugs at simultaneously increasing application of alternative methods in children and adolescents owing to the fact that it indicates a downward trend although somatic exposure of this population has increased. Therefore, it is recommended to state both the GSD and the level of somatic radiation exposure of the population taken from the individual sources for the comparison and assessment of radiation exposure from various sources in future. Although the somatically significant dose constitutes the ...
Apparatus and method for selective measurement of tritium oxide in an environment which may include other radioactive components and gamma radiation, the measurement including the selective separation of tritium oxide from a sample gas through a membrane into a counting gas, the generation of electrical pulses individually representative by rise times of tritium oxide and other radioactivity in the counting gas, separation of the pulses by rise times, and counting of those pulses representative of tritium oxide. The invention further includes the separate measurement of any tritium in the sample gas by oxidizing the tritium to tritium oxide and carrying out a second separation and analysis procedure as described above.
Thin films of high temperature garnet materials such as yttrium aluminum garnet (YAG) doped with rare earths are currently being investigated as selective emitters. This paper presents a radiative transfer analysis of the thin film emitter. From this analysis the emitter efficiency and power density are calculated. Results based on measured extinction coefficients for erbium-YAG and holmium-YAG are presented. These results indicated that emitter efficiencies of 50 percent and power densities of several watts/sq cm are attainable at moderate temperatures (less than 1750 K).
The radiative transport problem is cast in integral form using a transport kernel. The transport kernel has an explicit representation in terms of a Feynman Path Integral over all paths between selected points in a volume. This representation is setup in detail. Numerical evaluation of this Path Integral is formulated with a Frenet-Serret based procedure for generating valid random paths, and with a numerical evaluation of the weight for each valid path. Very early sanity checks of a numerical implementation are reported. Approaches to optimization are identified. (authors)
Purpose To study the activation and expression of vascular (aorta and small mesenteric arteries) potassium channels during septic shock with or without modulation of the NO pathway. Methods Septic shock was induced in rats by peritonitis. Selective inhibitors of vascular KATP (PNU-37883A) or BKCa [iberiotoxin (IbTX)] channels were used to demonstrate their involvement in vascular hyporeactivity. Vascular response to phenylephrine was measured on aorta and small mesenteric arteries mounted on a wire myograph. Vascular expression of potassium channels was studied by PCR and Western blot, in the presence or absence of 1400W, an inducible NO synthase (iNOS) inhibitor. Aortic activation of the transcriptional factor nuclear factor-kappaB (NF-?B) was assessed by electrophoretic mobility shift as...
The aim of this study was to measure the nociceptive response (avoidance latency) of the land snail Megalobulimus abbreviatus (N=8 in each group) after topical capsaicin exposure (0.1% and 0.5% in 20% ethanol) and to compare it to a well-studied stressful (50??C) thermal stimulus model. We also tested if ruthenium red, and capsazepine, respectively nonselective and selective TRPV1 receptor antagonists, could modify both capsaicin- and thermal-evoked responses. Finally, animals were pretreated with morphine, naloxone or morphine plus naloxone prior to capsaicin stimuli. Latencies were measured when the animal lifted its head?foot complex 1?cm from the substrate. Data were compared using ANOVA and LSD post hoc, and the Student T Test (pM. abbreviatus.
The simplest high gain free electron laser (FEL) amplifier concept is proposed. A klystron amplifier has the useful property that the various electronic processes take place in separate portions of the amplifier, rather than overlapping as in FEL amplifier with an uniform undulator. The klystron consists of two fundamental parts: succession of 2-3 cascades (modulator), and an output undulator (radiator) in which the modulated electron beam coherently radiates. Each cascade consists of uniform undulator and dispersion section. Unlike distributed optical klystrons, we have a high gain per cascade pass. This has a few consequences. First, klystron gain does not depend on the bunch compression in the injector linac, i.e. maximum gain per cascade pass at high peak beam current is the same at low peak beam current, without compression. Conventional, short-wavelength FEL amplifier and distributed optical ...
Radiation technology offers a very wide scope for utilisation and commercial exploitation in various field. All over the world, this technology is being favourably considered for different applications like radiation sterilisation of medical products, preservation of food by controlling the physiological processes for extending shelf-life and eradication of microbial and insect pests, radiation processing of polymeric materials and treatment of sewage sludge. Bangladesh Atomic Energy Commission has taken radiation processing programmes in a big way right from its inception. This paper describes the studies carried out by various research groups in Bangladesh Atomic Energy Commission mainly using Cobalt-60 gamma radiation. The investigation covers medical sterilisation, food preservation and development and modification of polymeric materials by gamma radiation. ...
Thermophotovoltaic (TPV) systems are attractive possibilities for direct thermal-to-electric energy conversion, but have typically required the use of black body radiators operating at high temperatures. Recent advances in both the understanding and performance of solid rare-earth oxide selective emitters make possible the use of TPV at temperatures as low as 1200K. Both selective emitter and filter system TPV systems are feasible. However, requirements on the filter system are severe in order to attain high efficiency. A thin-film of a rare-earth oxide is one method for producing an efficient, rugged selective emitter. An efficiency of 0.14 and power density of 9.2 W/KG at 1200K is calculated for a hypothetical thin-film neodymia (Nd2O3) selective emitter TPV system that uses radioisotope decay as the thermal energy source.
The aim of this study was to evaluate the differences in accuracy of dose calculation between 3 commonly used algorithms, the Pencil Beam algorithm (PB), the Anisotropic Analytical Algorithm (AAA), and the Collapsed Cone Convolution Superposition (CCCS) for intensity-modulatedradiation therapy (IMRT). The 2D dose distributions obtained with the 3 algorithms were compared on each CT slice pixel by pixel, using the MATLAB code (The MathWorks, Natick, MA) and the agreement was assessed with the gamma function. The effect of the differences on dose-volume histograms (DVHs), tumor control, and normal tissue complication probability (TCP and NTCP) were also evaluated, and its significance was quantified by using a nonparametric test. In general PB generates regions of over-dosage both in the l...
An electronically controllable apparatus is described which modulates a continuous wave laser beam so as to produce an output beam consisting of coherent ''pulses'' that are electronically controllable as to both pulse repetition rate and pulse width. The apparatus includes two acoustic devices positioned so that the laser beam passes through them in sequence, and apparatus or for passing sound waves through the devices to frequency shift the laser radiation as well as to diffract it. Each acoustic device such as generates sound waves containing a group of frequencies which result in spaced pulses. The spreading of a laser beam at which emanates from the first acoustic device is countered by the second acoustic device to produce a collimated, coherently pulsed, laser beam.
The iodinated oil lipiodol is commonly used as a carrier for in situ delivery of drugs or radioactivity to hepatic tumors. Recently, we reported a new kit formulation for high-activity labeling of lipiodol with the {beta}-emitting radionuclide Re-188. Since the whole preparation involves different steps and complex manipulations of high-activity samples, we describe here an automated synthesis module that allows the easy preparation of sterile and pyrogen-free samples of Re-188 lipiodol ready to be administered to the patient. Important advantages include the possibility to incorporate high Re-188 activity into the lipiodol hydrophobic phase and a sharp reduction of radiation exposure of the operator assisting the labelling procedure. Application of this modular reaction system could be also extended to the preparation of other Re-188 radiopharmaceuticals and to compound labelled with different {beta}-emitting therapeutic radionuclides.
The purpose of this study was to compare 2 adaptive radiotherapy strategies with helical tomotherapy. A patient having mesothelioma with mediastinal nodes was treated using helical tomotherapy with pretreatment megavoltage CT (MVCT) imaging. Gross tumor volumes (GTVs) were outlined on every MVCT study. Two alternatives for adapting the treatment were investigated: (1) keeping the prescribed dose to the targets while reducing the dose to the OARs and (2) escalating the target dose while maintaining the original level of healthy tissue sparing. Intensity modulated radiotherapy (step-and-shoot IMRT) and 3D conformal radiotherapy (3DCRT) plans for the patient were generated and compared. The primary lesion and nodal mass regressed by 16.2% and 32.5%, respectively. Adapted GTVs and reduced plan...
Oncospheres produced by a nonirradiated worm and oncospheres produced by a worm that had been subjected to high gamma radiation (successive generations of cysticercoids were irradiated with 15,000 r until a cumulative dose of 120,000 r was obtained) were compared. Radiation had no effect on the sizes of the embryos, the shell, and the median hooks. Radiation may have resulted in certain large, hookless embryos that did not occur in the normal worm. Two anomalies, reduced hook number and failure of growth, were more frequent in the normal than in the irradiated worm. This result, although surprising, can be explained by the high selection pressure operating under the experimental conditions. (auth)
The estimation of radiation dose to man from either external or internal exposure to radionuclides requires a knowledge of the energies and intensities of the atomic and nuclear radiations emitted during the radioactive decay process. The availability of evaluated decay data for the large number of radionuclides of interest is thus of fundamental importance for radiation dosimetry. This handbook contains a compilation of decay data for approximately 500 radionuclides. These data constitute an evaluated data file constructed for use in the radiological assessment activities of the Technology Assessments Section of the Health and Safety Research Division at Oak Ridge National Laboratory. The radionuclides selected for this handbook include those occurring naturally in the environment, those of potential importance in routine or accidental releases from the nuclear fuel cycle, those of current interest in ...
The purpose of this note is to provide guidance to those who have duties under the Health and Safety at Work Act and other relevant legislation. It gives guidance on the practical application of legislation, concerning radiotherapy equipment. Two particular issues arise out of the requirements of Regulation 33 of the Ionising Radiations Regulations 1985 (IRR85) in relation to equipment which is used for medical exposures. These are the requirement to select, install and maintain this type of equipment in such a way that it is capable of restricting, so far as reasonably practicable, the medical exposure of any person where this is compatible with the intended clinical purpose, including the need to ensure that equipment used for radiotherapy is properly calibrated, and the requirement to notify the Health and Safety Executive (HSE) when an incident occurs involving a malfunction or defect in any 'radiation ...
While it is quite obvious that photons have an essential role in photochemical and photocatalytic processes, it is not simple to analyse the radiation process. A simple approach is presented on the assumption that photons can be treated as immaterial reactants. It is then possible to evaluate the radiation process in terms of parameters such as conversion, selectivity and yield, which are common in the conventional reaction engineering, and of an additional parameter, a volume efficiency factor, which accounts for the exploitation of the reaction volume as the result of the inevitable attenuation of the radiation in the transport through the participating medium. Attention has also been focused on the validation of kinetic data when, as it is usually done, they are interpreted in terms of volume averages. Finally, guidelines have been prepared to support preliminary phases of analysis and/or design of a ...
Purpose: This study presents a dosimetric optimization effort aiming to compare intensity-modulated (IM) X-rays and IM protons in 4 different orbital and paraorbital tumors. These are most challenging targets for standard radiotherapy due to their close relationship with the eyes and related structures. Methods and Materials: A primary orbital lymphoma, an optic nerve meningioma, a sphenoidal ridge meningioma protruding into the orbit, and a pediatric parameningeal paraorbital rhabdomyosarcoma were selected for the purpose of this study. Planning target volumes (PTVs) and organs at risk (OAR) were defined in each patient CT data set for each tumor site. IM X-ray and IM proton three-dimensional treatment plans were implemented. The following total tumor doses were prescribed: 30 Gy for the orbital lymphoma, 54 Gy for both meningiomas, and 50.4 Gy for the rhabdomyosarcoma case. Dose-volume histograms (DVHs) were obtained for all targets and OAR ...
The feasibility was studied of the application of radionuclide X-ray fluorescence analysis to the identification and determination of chemical elements in the air. A description of the method is presented, the main stages of the analysis are discussed (sample preparation and standards, selection of radioactive radiation sources, geometry of measurement and evaluation of results). The method is illustrated on the determination of elements Fe, Cu, Zn, Br, and Pb in air samples taken in the city of Prague. (author) 2 tabs., 2 figs., 14 refs.
The application of robotics for repair, refurbishing or dismantling of nuclear installations implies eventually severe radiation resistance requirements on embarked components and subsystems. This is particularly critical when optical sensing is considered. Optoelectronic components and optical fibers are indeed quite sensitive to radiation, and without special design are rapidly out-of-operation in such an environment. This paper reports the results of a series of #gamma# irradiation experiments on such devices, and identify their behavior under radiation. Test results show that carefully selected optical fibers can keep their radiation induced attenuation lower than 0.3 dB/m even up to a total dose of 10 MGy. Temperature annealing can even lower this attenuation down to 0.1 dB/m. On the other hand, commercially available light emitting diodes and photodiodes present attenuations ...
The thermal radiation which generated from the patterned Ta/Pt/Ta thin heater achieved a high temperature up to 1010 {sup o}C under applied current of 2.4 A. In order to reduce an electromigration at high current of 2 A, a Ta capping layer was placed on the Pt layer instead of conventional capping layer, such as SiNx and CoWP. Under the thermal radiation at the applied current of 2 A in the Ta/Pt/Ta thin heater, the Ta capping layer enhanced the lifetime of the Pt thin heater up to 5 h. A stamping process for the crystallization of a-Si was performed for 40 samples using the Ta/Pt/Ta thin heater. For all samples, a-Si has been selectively crystallized and Raman peaks were located near 519 cm{sup -} {sup 1}. These results indicated that the thermal radiation of the Ta/Pt/Ta thin heater was maintained constantly due to the Ta capping.
Tetracycline is an antibiotic that absorbs ultraviolet light at 355 nm and preferentially binds to atherosclerotic plaque both in vitro and in vivo. Tetracycline-treated human cadaveric aorta was compared with untreated aorta using several techniques: absorptive spectrophotometry; and tissue uptake of radiolabeled tetracycline, which showed 4-fold greater uptake by atheroma than by normal vessel. In addition, intravenous tetracycline administered to patients undergoing vascular surgery demonstrated characteristic fluorescence in surgically excised diseased arteries. Because of tetracycline's unique properties, the authors exposed tetracycline-treated and untreated aorta to ultraviolet laser radiation at a wavelength of 355 nm. They found enhanced ablation of tetracycline-treated atheroma compared with untreated atheroma. The plaque ablation caused by ultraviolet laser radiation was twice as extensive in tetracycline-treated vs ...
Background and purpose: the recent RTOG guidelines for future clinical developments in gynecologic malignancies included the investigation of dose escalation in the paraaortic (PO) region which is, however, very difficult to target due to the presence of critical organs such as kidneys, liver, spinal cord, and digestive structures. The aim of this study was to investigate intensity-modulated radiotherapy's (IMRT) possibilities of either increasing, in a safe way, the dose to 50-60 Gy in case of macroscopic disease or decreasing the dose to organs at risk (OR) when treatment is given in an adjuvant setting. Material and methods: the dosimetric charts of 14 patients irradiated to the PO region at the department of radiation oncology, university hospital of Liege, Belgium, in 2000 were analyzed in order to compare six-field conformal external-beam radio-therapy (CEBR) and five-beam IMRT approaches. Both CEBR and IMRT investigations were planned to ...
Full text: The principal nuclear design tools available to the shielding designer include diffusion approximation, transport theory, and Monte Carlo techniques. Full transport theory or Monte Carlo methods are routinely used for shielding analyses, where penetration investigations are more sensitive to directional aspects. However, the aim of this paper is to illustrate the coupled neutron-gamma Albedo method particularly as applied to problems of shielding analysis. The multigroup Albedo method is applied to coupled neutron-gamma radiations considering 'n' neutron energy groups and 'g' gamma energy groups to estimate the probabilities of transmission through, absorption in, and reflection from shieldings composed by multiple material layers, 'm' slabs, in which no fission occurs. In this study, these energy groups were selected in order to minimize upscattering effects of the radiation from lower energy groups to higher ...
Full text: The general population is daily exposed to chronic, low doses of ionizing radiation (IR) from both natural and artificial sources. The biological consequences of acute, high dose IR exposure can be readily determined; however, the nature and significance of low dose, low dose-rate IR effects are still the subject of debate. Confounding the issue, are the phenomena collectively referred to as the Radiation-induced Bystander Effect (RIBE). The RIBE describes a collection of in vitro observations that suggest the presence of a soluble, transmissible factor(s) released from irradiated cells that can induce a biological response in un-irradiated cells. The induction, nature and magnitude of the RIBE varies between cell culture systems, radiation sources and end-points measured. Efforts to confirm the presence of the RIBE in vivo have been confined to in vivo-like culture systems and limited work with tumour and ...
This paper describes the design of PMT readout module for detector prototype of Daya Bay Reactor Neutrino Experiment. According to the design requirements of the readout module, the basic structure of the readout module is discussed. This paper also discusses how to realize the charge measurement and time measurement and data processing using a high performance FPGA. The DAQ system including three readout modules and one trigger module are well commissioned and doing data taking now. (authors)
According to ICRP 60 and European-Directive 96/29, Naturally Occurring Radioactive Materials (NORM) and Technical Enriched Naturally Occurring Radioactive Materials (TENORM) have to take the radiation protection of the general population as well as of workers into account. The German radiation protection regulations stress that particularly. In connection with these regulations, various measurement programs have been and still are performed to investigate the relevant exposure paths. One of these programs is the determination of the intake of natural occurring radionuclides of the uranium decay series in individuals of the public, in exposed regions and houses and also at NORM workplaces by excretion analysis. Excretion analysis surveillance is one of the common tools for internal dosimetry. Sources of primordial radionuclides could be the ingestion of foodstuff and water and the incorporation of (mostly airborne) pollution on work places. The ...
The thermophotovoltaic (TPV) option was not selected for further deep space mission technology development in NASA for several reasons. Chief among them was the large radiator required to keep the photovoltaic cells at a sufficiently low operating temperature. This led to significant integration problems with the spacecraft and limited sensor view angles. It is clear that the issue of cell temperature is crucial for space applications because of radiator size and system impact. Many efforts have focused on matching cell band gap to appropriate emitters in the 1 to 2 {mu}m range, resulting in band gaps in the 0.5 to 0.8 eV range. However, low band gaps lead to low open circuit voltages ({approximately}0.25 to 0.45 V) caused by high intrinsic carrier concentrations (n{sub i}{sup 2}). Thus, in order to obtain high performance. Photovoltaic cell temperatures must be kept near room temperature. This leads to the inevitable ...
In this updated second edition, the order of contents of the textbook has been reorganized. It has been divided into main parts: Basic Science and Clinical Nuclear Medicine. Basic Science, Part I, encompasses basic physics, radiation protection, interaction of radiation with matter and radiation detection, imaging, nuclear pharmacy, and radiation biology. Part II, Clinical Nuclear Medicine, covers the central nervous system, bone, gastroenterology (liver/spleen), cardiovascular system, pulmonary system, genitourinary system, thyroid and endocrine systems, gallium studies, radioassay, hematology, and therapy. The total number of pages of the current edition is increased to 250 from the 213 of the first edition but there are fewer questions because those in the basic science area have been carefully selected to 60 of the original 98 questions. Compared with the previous edition, there ...
Two local repair procedures, one without (9) and the other with (14) a bulbocavernosus muscle graft were performed on 20 patients with a radiation induced rectovaginal fistula. Four patients had two procedures successively. The initial success rate of both procedures was 7/9 and 14/14 respectively. Though the initial result of the bulbocavernosus graft was obviously better, in many of the local repair procedures, subclinical radiation damage progressed, resulting in recurrence of rectovaginal fistula (5), rectovesical fistula (4), pararectal abscess (2) etc. After a mean follow up of around 10 years, the success rate of fistula repair decreased to 5/9 and 13/14 and only 2/9 and 6/14 finally remained without a colostomy. A local repair operation should be restricted to carefully selected cases. The musculus gracilis is proposed as a better vascular graft. If the general condition of the patient does not allow more aggressive ...
Handheld, backpack, and mobile sensors are elements of the Global Nuclear Detection System for the interdiction and control of illicit radiological and nuclear materials. They are used by the U.S. Department of Homeland Security (DHS) and other government agencies and organizations in various roles for border protection, law enforcement, and nonproliferation monitoring. In order to systematically document the operational performance of the common commercial off-the-shelf portable radiation detection systems, the DHS Domestic Nuclear Detection Office conducted a test and evaluation campaign conducted at the Nevada Test Site from January 18 to February 27, 2006. Named 'Anole', it was the first test of its kind in terms of technical design and test complexities. The Anole test results offer users information for selecting appropriate mission-specific portable radiation detection systems. The campaign also ...
The use of hypothesis which assumes a dose / harmful effect relationship without a limit allows the calculation of risks attributable to doses too small to produce detectable, harmful biological effects. The daughter product of this hypothesis is ALARA concept which requires that the dose received is kept as low as reasonably achievable. This concept of prudent avoidance is generally accepted by international radiation protection organisations and universally applied by radiation health professionals. The acceptance of a hypothesis which assumes that a single nuclear event can cause carcinogenesis, has generated levels of anxiety which may have resulted in significant detriment to those possibly exposed to ionising radiation. The anxiety generated may have caused more detriment and a higher death rate than the worst case ` theoretical` value calculated using the Linear or Quadratic Linear Hypothesis. Information ...
Disclosed in this proposal are plans to construct a patent pending wrist module with computer control, configurable to form high-dexerity telerobotic arms ...
Purpose/Objective: The role of programmed cell death (apoptosis) as a cellular response to cancer therapy such as radiation or chemotherapy is the subject of much study, and manipulation of the apoptotic response in tumor cells may be valuable in the treatment of a variety of cancers. Both p53 dependent and independent apoptotic pathways have been identified; p53 is mutated in at least 50 % of human cancers and a majority of radiation resistant tumors contain p53 mutations. This study is designed to examine the induction of programmed cell death in a human colon carcinoma cell line that possesses two mutated p53 alleles. Ionizing radiation alone, or in combination with the chemotherapeutic drug 5-fluorouracil (5-FU), were used to elicit the apoptotic response. This study will focus on whether these treatments can induce a significant apoptotic response in cells that have mutated p53 alleles. Materials and Methods: HT-29 ...
RESRAD was one of the multimedia models selected by the US Nuclear Regulatory Commission (NRC) to include in its workshop on radiation dose modeling and demonstration of compliance with the radiological criteria for license termination. This paper is a summary of the presentation made at the workshop and focuses on the 10 questions the NRC distributed to all participants prior to the workshop. The code selection criteria, which were solicited by the NRC, for demonstrating compliance with the license termination rule are also included. Among the RESRAD family of codes, RESRAD and RESRAD-BUILD are designed for evaluating radiological contamination in soils and in buildings. Many documents have been published to support the use of these codes. This paper focuses on these two codes. The pathways considered, the databases and parameters used, quality control and quality assurance, benchmarking, verification and validation of ...
Joint FAO/IAEA/WHO Expert Committee approved the use of radiation treatment of foods. Nowadays food packaging are mostly made of plastics, natural or synthetic, therefore effect of irradiation on these materials is crucial for packing engineering for food irradiation technology. By selecting the right polymer materials for food packaging it can be ensured that the critical elements of material and product performance are not compromised. When packaging materials are in contact with food at the time of irradiation that regulatory approvals sometimes apply. The review of the R-and-D and technical papers regarding material selection, testing and approval is presented in the report. The most information come from the USA where this subject is well elaborated, the International Atomic Energy Agency (IAEA) reports are reviewed as well. The report can be useful for scientists and food irradiation plants operators. (author)
Industrial radiography accounts for approximately half of all the reported accidents for the nuclear related industry, in both developed and developing countries. This Safety Report is the result of a review made of a large selection of accidents in industrial radiography reported by regulatory authorities, professional associations and scientific journals. A small, representative selection of 43 accident descriptions has been used to illustrate the primary causes of radiography accidents, and a set of measures provided to prevent the recurrence of such accidents or to mitigate the consequences of those that do occur. These accident descriptions were categorized by primary causes as follows: inadequate regulatory control; failure to follow operational procedures; inadequate training; inadequate maintenance; human error; equipment malfunction or defect; design flaws; and wilful violation. The information in this Safety report is intended for use ...
Microbiological comparison between irradiated and non-irradiated foodstuff has been studied for a long time as a way to detect whether a foodstuff has been irradiated or not. Generally, the proposed methods are based on the fact that ionization select species of bacteria which are recognized to be radioresistant. So reduction or elimination of known radiation sensitive microbes from the normal endogenous microflora could give an indication that the foodstuff has been irradiated, predominance of known radioresistant bacteria should be another indication. In the present work, we try to develop a test based on the radiosensitivity of the bacteria independently of their place. These first experiments show that the determination of radiosensitivity of strains isolated from a product or even of global radioresistance of mesophilic microflora could indicate if this product has been previously submitted to ionizing radiations. (4 ...
Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 {mu}s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatial position and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kicks are reported as a function of charge.
Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 {mu}s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatial position and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kicks are reported as a function of charge.
Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 [mu]s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatialposition and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kick effects are reported as a function of charge.
Time-resolved characterizations of electron beams using optical transition radiation (OTR) as a prompt conversion mechanism have recently been extended on the Los Alamos Free-electron Laser (FEL) facility 40-MeV linac. Two key timescales for rf-linac driven FELs are the micropulse (10 ps) and the macropulse (5 {mu}s to 1 ms). In the past we have used gated, intensified cameras to select a single or few micropulses (25 to 400 ns gate width) out of the pulse train to evaluate submacropulse effects. Recently, we have obtained some of the first measurements of micropulse bunch length (7 to 10 ps) and submacropulse spatialposition and profile using OTR and a Hamamatsu streak camera. Additionally, micropulse elongation effects and head-to-tail transverse kick effects are reported as a function of charge.
A 150 Watt thermophotovoltaic (TPV) power generator is being developed. The technical approach taken in the design focused on optimizing the integrated performance of the primary subsystems in order to yield high energy conversion efficiency and cost effectiveness. An important aspect of the approach is the use of a selective emitter radiating to a bandgap matched photovoltaic array to minimize thermal and optical recuperation requirements, as well as the non-recoverable heat losses. For the initial prototype system, fibrous ytterbia emitters radiating in a band centered at 980 nm are matched with high efficiency silicon photoconverters. The integrated system includes a dielectric stack filter for optical energy recovery and a ceramic recuperator for thermal energy recovery. The system has been operated with air preheat temperatures up to 1350K. The design of the system and development status are presented. {copyright} ...
The activity of tyrosine aminotransferase (TAT) in the liver of mice subjected simultaneously to ionizing radiation and to local inflammatory process showed in the first 24 hours of the experiment statistically significant changes resulting from summation of the harmful effects of both factors. In the second 24-hour period an evident tendency was observed for return of a normal circadian rhythm of the enzyme. This points to presence of an endogenous mechanism of suppression of the manifestations of significant desynchronization of the circadian rhythm. The paper contains also a trial of mathematical analysis of changes in TAT activity in the circadian rhythm, a description and analysis or the suppression process, qualitative and quantitative determination of the phenomenon of cumulation of the effects of powerful stress factors acting on the animal organism. The obtained results were compared with the results of investigations of TAT activity changes obtained in ...
Fibre-reinforced-polymer-composite material has been suggested as a bearing material to overcome tribological problems witnessed during the testing of Ram assembly of the 540 MWe fuelling machine at RTD. After successful trials at B-Ram the composite material has been adapted for B-RAM, C-Ram and RDB head at fuelling machines being tested at RTD, Hall 7 and at Tarapur. Laboratory evaluations were also carried out at Tribology Lab RTD to study effect of radiation on the composite. Paper deals with the various aspects of life prediction of this material in term of wear and radiation damage. (author)
Retrospective analyses were performed to evaluate the therapeutic efficacy of intra-oral cone (IOC) radiation therapy for carcinoma of the oral tongue, especially about its faculty of local control and complications. Thirty-nine patients with squamous cell carcinoma of the oral tongue were treated with IOC radiation therapy alone or in combination with external irradiation. IOC radiation therapy was given not only for T1 and T2, but also for T3 tumors. Hypofractionation was used for IOC radiation therapy. The 2 year local control rates, including surgical salvage, for T1, T2, T3 and T4 were 100%, 73.3%, 40% and 0%, respectively. The 5 year actuarial survival rates for Stage I, II, III and IV were 100%, 65.3%, 35.4% and 0%, respectively. The incidences of radiation complications, i.e. soft tissue ulceration and osteoradionecrosis, were 42.9% and 2.9%, respectively. It is suggested ...
It is anticipated that early in the next century manned missions into outer space will occur, with a mission to Mars scheduled between 2015 and 2020. However, before such missions can be undertaken, a realistic estimation of the potential risks to the flight crews is required. One of the uncertainties remaining in this risk estimation is that posed by the effects of exposure to the radiation environment of outer space. Although the composition of this environment is fairly well understood, the biological effects arising from exposure to it are not. The reasons for this are three-fold: (1) A small but highly significant component of the radiation spectrum in outer space consists of highly charged, high energy (HZE) particles which are not routinely experienced on earth, and for which there are insufficient data on biological effects; (2) Most studies on the biological effects of radiation to date have been high-dose, high ...
We introduce a methodology for analysis of multiwavelength data from X-ray selected BL Lac (XBL) objects detected in the TeV regime. By assuming that the radio--through--X-ray flux from XBLs is nonthermal synchrotron radiation emitted by isotropically-distributed electrons in the randomly oriented magnetic field of a relativistic blazar jet, we obtain the electron spectrum. This spectrum is then used to deduce the synchrotron self-Compton (SSC) spectrum as a function of the Doppler factor, magnetic field, and variability timescale. The variability timescale is used to infer the comoving blob radius from light travel-time arguments, leaving only two parameters. With this approach, we accurately simulate the synchrotron and SSC spectrum of flaring XBLs in the Thomson through Klein-Nishina regimes. Photoabsorption by interactions with internal jet radiation and the intergalactic background light (IBL) is included. Doppler ...
This invention is concerned with a solar energy system for propelling aircraft. Obtained are forces for aerodynamic lift and impetus. The lifted body had a transparent upper surface for the sun light, but black or reflecting for IR-radiation and high thermal insulation properties. Inside of the lifted body, the air temperature increases and is lifted by convection influence. The air resistance of this body is low in horizontal direction and higher in vertical position. The payload could be shifted, so that the positive or negative angle of the whole body can be selected. By this principal it is possible to transform the static lifting force in a dynamic impetus.
This study was conducted to investigate the decomposition of three {gamma}-irradiated antibiotics (e.g., tetracycline, sulfamethazine, and lincomycin) and to compare the toxic effects on Daphnia magna, Vibrio fischeri, and Pseudokirchneriella subcapitata. The median cell growth inhibition concentrations (IC{sub 50}) of tetracycline, lincomycin, and sulfamethazine for P. subcapitata dramatically increased (e.g., toxicity decreased) after radiolysis. The results demonstrated that {gamma}-radiation treatment was efficient to decompose antibiotics and thereby their toxicity on P. subcaptitata remarkably decreased due to reduced parent compounds.
CERN has encouraged the US-LARP collaboration to participate in Phase I of the LHC luminosity upgrade by analyzing the benefits gained by using Nb3Sn technology to replace the functionality of select NbTi magnets that CERN is committed to construct. Early studies have shown that the much higher gradients (shorter magnetic lengths) and temperature margins (quench stability) of Nb3Sn magnets compared to their NbTi counterparts is favorable--allowing the insertion of additional absorbers between Q1 and Q2, for example. This paper discusses the relative merits of the NbTi and Nb3Sn options.
A study is made of plant sensitivity to mutagens during the processing of seeds. An examination is made of problems concerned with modification mutability, the nature of plant restoration following irradiation. Particular attention is given to mutation changes. A presentation is made of several features of mutant changes initially selected by separate indicators. An examination is made of the possible study of mutant indicator genetics. General data on the forms and varieties produced by the mutagenesis method are given. The book is designed for breeding specialists and geneticists engaged in the study of mutagenesis. 439 references, 27 figures, 66 table.
The authors trace the early history of nuclear power regulation in the US. Focusing on the Atomic Energy Commission, they describe the role of other groups that figured in the development of regulatory policies, including the Congressional Joint Committee on Atomic Energy, other federal agencies, state governments, the nuclear industry, and scientific organizations. They consider changes in public perceptions of and attitudes toward atomic energy and the dangers of radiation exposure. The basic purpose of the book is to provide the Nuclear Regulatory Commission and the general public with information on the historical antecedents and background of regulatory issues so that there will be continuity in policy decisions. The book concludes with an annotated bibliography of selected references. 19 figures.
As a first step an attempt was made to integrate a personnel information facility into a system for optimising materials flow. The two systems developed did not reach a workable stage because the synthetic language would have required an input on the part of the personnel operating the system beyond what could reasonably be expected. The research in the second stage consisted in developing and testing a module with which language storage services could be built up on the basis of digitalised speech and controlled via the in-house telephone network. In language storage services users may feed in data or interrogate. Services of this kind can readily be integrated into available telephone installations working on the pulse selection principle. The low cost of the hardware involved means the system can be built up with modest investment while offering high effectiveness. 6 refs., 2 figs.
In 1998, in the frame of the ITER EDA phase, an European R and D Programme for the Blanket Design was implemented for developing and selecting the materials and the relevant fabrication procedures for manufacturing the shielding modules of the ITER Primary Wall. The fabrication of several Beryllium armored small scale mock-ups, reproducing representative portions of a Primary Wall panels, was also launched (Fusion Technol. (1998) 195). Further experimental activities were also programmed for investigating the thermal-mechanical behavior of these mock-ups at high heat flux and under thermal fatigue tests. In 2001, the ITER European Home Team decided to assign to ENEA a contract for the thermal fatigue testing of six mock-ups aiming at verifying the reliability of the Beryllium/Dispersion Strengthened Copper alloy/Stainless Steel and Beryllium/Precipitation hardened Copper alloy/Stainless Steel joints manufactured by solid Hot Isostatic Pressing ...
This report describes the fiscal 1998 result on development of genome informatics technology. As comparative analysis technique of genes, the combination of electrophoresis and PCR was used. For improvement of the throughput and reproducibility of the technique, module- shuffling primers were used, and the multi(96)-arrayed capillary fragment analyzer was devised. The system detecting SNPs rapidly was also developed successfully. As analysis technology of DNA sequence by use of triple- stranded DNA formation, study was made on construction of long cDNA libraries, selective subtraction of specific sequences from libraries, and the basic technology of homologous cloning. Study was also made on each reaction step of IGCR technique for fast analysis, and specifications of a fluorescence transfer monitor. As modeling technique of genetic sequence information, the simulation model was developed for gene expression regulatory networks during muscle ...
Crystallography and computer modeling have been used to exploit a previously unexplored channel in the glucocorticoid receptor (GR). Highly potent, nonsteroidal indazole amides showing excellent complementarity to the channel were designed with the assistance of the computational technique AlleGrow. The accuracy of the design process was demonstrated through crystallographic structural determination of the GR ligand-binding domain-agonist complex of the D-prolinamide derivative 11. The utility of the channel was further exemplified through the design of a potent phenylindazole in which structural motifs, seen to interact with the traditional GR ligand pocket, were abandoned and replaced by interactions within the new channel. Occupation of the channel was confirmed with a second GR crystal structure of this truncated D-alaninamide derivative 13. Compound 11 displays properties compatible with development as an intranasal solution formulation, whereas oral bioavailability has been ...
In this paper a computational analysis of 11 fuel samples (seven UO_2 and four MOX) with a burn-up ranging from 20 MWd/kgHM up to 121 MWd/kgHM (HM: Heavy Metal) is carried out with the depletion module of the lattice code CASMO-4E [Rhod01, Rhod01b] using the neutron data libraries ENDF/B-VI and JEF-2.2 and a pin cell model. In order to assess the accuracy of the model and the depletion calculation in the determination of the isotopic inventory after several irradiation cycles, the calculated results were compared to experimental data gathered from a chemical isotopic analysis of the fuel samples performed at the Hot Laboratory at the Paul Scherrer Institut (PSI), Switzerland. Selected results of this comparison, which includes 54 isotopes (17 actinides and 37 fission products), are presented here. (orig.)
Recently a new method of controlling the pulse length of a short-pulse free-electron laser (FEL) has been developed. By modulating the synchronism between the optical and electron pulses in the FEL cavity, it was found that the output power and the micropulse length of the FEL beam oscillates at the modulation frequency. In this paper, we study theoretically the behavior of the micropulse length, both in the high loss (steady state) regime and the low loss (limit cycle) regime, when a modulated desynchronism is applied. In order to do this, we analyze the dynamics of a short-pulse FEL oscillator. The modulation frequency value plays an important role in the dynamics. We find that there is a resonantlike phenomenon between the externally applied desynchronism modulation and the limit cycle oscillation without modulation of a free-electron laser.
Aimed at some typical constraints of police dogs and robots used in the areas of reconnaissance and counterterrorism currently, the multifunction anti-terrorism robotic system based on police dog has been introduced. The system is made up of two parts: portable commanding device and police dog robotic system. The portable commanding device consists of power supply module, microprocessor module, LCD display module, wireless data receiving and dispatching module and commanding module, which implements the remote control to the police dogs and takes real time monitor to the video and images. The police dog robotic system consists of microprocessor module, micro video module, wireless data transmission module, power supply module and offence weapon module, which real time collects ...
In this paper the authors present the first emitter efficiency results for the thin film 40 percent Er-1.5 percent Ho YAG (Yttrium Aluminum Garnet, Y3Al5O12) and 25 percent Ho YAG selective emitter at 1500 K with a platinum substrate. Spectral emittance and emissive power measurements were made (1.2 less than lambda less than 3.2 microns). Emitter efficiency and power density are significantly improved with the addition of multiple rare earth dopants. Predicted efficiency results are presented for an optimized (equal power density in the Er, (4)I[sub 15/2]-(4)I[sub 13/2] at 1.5 microns, and Ho, (5)I[sub 7]-(5)I[sub 8] at 2.0 micron emission bands) Er-Ho YAG thin film selective emitter.
The details and principles of an apparatus built for measurements of fluorescence quantum yields and cascade-free lifetimes of open-shell cations are reported. These rely on the detection of coincidences between energy selected photo-electrons and undispersed photons. The results of such measurements for CO"+_2,COS"+,CS"+_2 and N_2O"+ in selected vibrational levels of their excited states are presented. Non-unity fluorescence quantum yields are found for some vibronic levels of CO"+_2(B), COS"+(A), N_2O"+(A) and a non-exponential decay is observed for CS"+_2(B). The data yield the following values for the radiative lifetimes: CO"+_2(A) 124 +- 6 ns,CO"+_2(B) 140 +- 7 ns, COS"+(A) 550 +- 50 ns and N_2O"+(A) 240 +- 12 ns. (orig.).
Full text: DNA rearrangement events leading to chromosomal aberrations are central to ionizing radiation-induced cell death. Although DNA double-strand breaks are probably the lesion that initiates formation of chromosomal aberrations, little is understood about the molecular mechanisms that generate and modulate DNA rearrangement. Examination of the sequences that flank sites of DNA rearrangement may provide information regarding the processes and enzymes involved in rearrangement events. Accordingly, we developed a method using inverse PCR that allows the detection and sequencing of putative radiation-induced DNA rearrangements in defined regions of the human genome. The method can detect single copies of a rearrangement event that has occurred in a particular region of the genome and, therefore, DNA rearrangement detection does not require survival and continued multiplication of the affected cell. Ionizing ...
In this paper, we put forward a systematic method to analyze, control and evaluate the safety issues of medical robotics. We created a safety model that consists of three axes to analyze safety factors. Software and hardware are the two material axes. The third axis is the policy that controls all phases of design, production, testing and application of the robot system. The policy was defined as hazard identification and safety insurance control (HISIC) that includes seven principles: definitions and requirements, hazard identification, safety insurance control, safety critical limits, monitoring and control, verification and validation, system log and documentation. HISIC was implemented in the development of a robot for urological applications that was known as URObot. The URObot is a universal robot with different modules adaptable for 3D ultrasound image-guided interstitial laser coagulation, radiation seed implantation, laser resection, ...
The UK Energy Research Centre (UKERC) in it's submission to the DTI's 2006 Energy Review reminded us that the 'UK has abundant wind, wave and tidal resources available; its mild climate lends itself to bio-energy production, and solar radiation levels are sufficient to sustain a viable solar industry'. These technologies are at different stages of development but they all draw on basic and applied Science and Engineering. The paper will briefly review the renewable energy technologies and their potential for contributing to a sustainable energy supply. Three research topics will be highlighted that bridge the gap between the physics underpinning the energy conversion, and the engineering aspects of development and deployment; all three are highly relevant to the Government's programme on micro-generation. Two are these are taken from field of thin film photovoltaics (PV), one related to novel device development and the other to a measurement technique for assessing ...
A LIXI (Light Intensifier X-ray Image) device has been employed in a real-time neutron radiography system. The LIXI is coupled to a video camera and the real-time images can be observed in a TV monitor, and processed in a computer. In order to get the real-time system operational, the neutron radiography facility installed at the IEA-R1 m nuclear research reactor of the IPEN-CNEN/S P has been optimized. The most important improvements were the neutron/gamma ratio, the effective energy of the neutron beam, decrease of the scattered radiation at the irradiation position, and the additional shielding of the video camera. Several one-frame as well as computer processed images are presented. The overall Modulation Transfer Function for the real-time system was obtained from the resolution parameter p = 0:44 +- 0:04 mm; the system sensitivity, evaluated for a Perspex step wedge, was determined and the average value is 0:70 +- 0:09 mm. (author)
The purpose of this study was to determine the optimal technique for delivering postoperative radiotherapy for vulvar cancer and other tumors requiring treatment of the inguinal nodes. This project compared tumor coverage and normal tissue sparing for the 5 main radiotherapy techniques that are used to treat vulvar cancer. The intensity-modulatedradiation therapy (IMRT) plan was undesirable because it resulted in an excessive dose to portions of the central pelvic structures. The photon thunderbird with skin match was unacceptable because it underdosed a portion of the groin region. The electron thunderbird was ideal for thin patients but was not applicable for most patients because of excessive dose to the skin and subcutaneous tissues. The photon through-and-through and the photon thunderbird with deep match were acceptable in most situations. In thin patients, where the depth of the inguinal vessels is less than 3 cm, the electron ...
Natural sunlight induces a genotoxic response in cultured CHO cells pre-treated with shale oil retort process water. Near ultraviolet light (NUV) component of the solar spectrum is the apparent radiation responsible for photoactivation. Cultured human skin fibroblasts are acutely sensitive to the genotoxic effects of photoactivated process water. The mutagenic potential of photoactivated process water in human cells is the same as that witnessed for an equivalent killing dose of the potent skin carcinogen FUV. DNA repair processes are involved in modulating genotoxic effects of this photo-induced process. The exact magnitude of the potential health-related and environmental risks resulting from photoactivation of retort process waters and other oil shale by-products is unassessed at this time. Our demonstration that a significant rate of mutation occurs in cultured human cells exposed to high dilutions of process waters and fluences of NUV ...
The magnetically controlled plasma opening switch (MCPOS) is an advanced plasma opening switch that utilizes magnetic fields to improve operation. Magnetic fields always dominate terawatt, pulsed power plasma opening switches. For that reason, the MCPOS uses controlled applied magnetic fields with magnitude comparable to the self-magnetic field of the storage inductor. One applied field holds the plasma in place while energy accumulates in the storage inductor, then another applied field pushes the plasma away from the cathode to allow energy to flow downstream. Over a ten month period, an MCPOS was designed, built, and tested on DECADE Module 2 at Physics International. The peak drive current was 1.8 MA in 250 ns. The output parameters were up to 1 MA into an electron beam load. The radiation temporal pulse width averaged 60 nanoseconds full-width at half-maximum. The peak load voltage ranged from one to two megavolts. The experiments ...
CT-Expo is a novel MS Excel application for assessing the radiation doses delivered to patients undergoing CT examinations, based on computational methods that were used to analyze the data collected in the German survey on CT practice in 1999. The program enables the calculation of all dose quantities of practical value, such as axial dose free-in-air, weighted CTDI, dose-length product, effective dose and uterine dose. In contrast to existing programs for CT dose assessment, CT-Expo offers a number of unique features, such as gender-specific dose calculation for all age groups (adults, children, newborns), applicability to all existing scanner models including correction of scanner-specific influences, and the possibility of comparison with the results from the German CT survey on CT practice. Three different application modules offer free and standardized dose calculations as well as a comprehensive benchmarking section including guidance on ...
The present study discusses the contribution of the adoption of more rigorous and objective criteria to the selection and analysis of information sources, leading to more scientific rigour when registering phytotherapic drugs. To this end, it is herein proposed the adoption of a previously tested and acknowledged methodology, namely the Systematic Revision, as a standard for phytotherapic drug analyses. In order to show differences brought about by the Systematic Revision during the registration procedures of phytotherapic drugs, the case of the Maytenus ilicifolia (known popularly in Brazil as 'espinheira-santa') is presented. As it is well known, the use of ionizing radiation is expanding, especially in medicine and pharmacy. Therefore, gamma radiation was applied to the microbiological quality control of phytotherapic matrices. Results indicated a positive contribution of Systematic Revision to the ...
Large-scale field tracer experiments have been conducted on Ulchin and Wolsung nuclear sites for the purpose of validating FADAS and of analyzing the environmental characteristics around the nuclear site. The most influential factor in atmospheric dispersion is the meteorological condition. During the experiment, meteorological data were measured on the release point and the selected positions among sampling points. Once radioactive materials are released to the atmosphere, members of public may be exposed through the environmental media such as air, soil and foods. Therefore, to protect the public, adequate countermeasures should be taken at due time for those exposure pathways. Both processes of justification and optimization are applied to a countermeasure simultaneously for decision-making. The work scope of biological research for the radiation protection had contained the search of biological microanalytic methods for the assessment of ...
In May 1990 a group of scientists representing several federal agencies, the International Society of Regulatory Toxicology and Pharmacology, the private sector, and academia met to develop a strategy to encourage the study of the biological effects of low level exposures (BELLE) to chemical agents and radioactivity. A workshop was held in 1991 with seven invited speakers focusing on the toxicological implications of biological adaptations. The selection of topics and speakers was designed to consider critically the concept of hormesis, not only in a broad, conceptual manner, but also at the molecular and biochemical levels. These presentations offered a complementary perspective on the diverse range of molecular mechanisms that can become activated at low levels of toxicant exposure. In addition to chemical toxicology research, an overview of current research on 'Effects of low-dose radiation on the immune response' was presented as well as ...
Background and purpose: the recent RTOG guidelines for future clinical developments in gynecologic malignancies included the investigation of dose escalation in the paraaortic (PO) region which is, however, very difficult to target due to the presence of critical organs such as kidneys, liver, spinal cord, and digestive structures. The aim of this study was to investigate intensity-modulated radiotherapy's (IMRT) possibilities of either increasing, in a safe way, the dose to 50-60 Gy in case of macroscopic disease or decreasing the dose to organs at risk (OR) when treatment is given in an adjuvant setting. Material and methods: the dosimetric charts of 14 patients irradiated to the PO region at the department of radiation oncology, university hospital of Liege, Belgium, in 2000 were analyzed in order to compare six-field conformal external-beam radio-therapy (CEBR) and five-beam IMRT approaches. Both CEBR and IMRT investigations were ...
This paper describes EPRI`s computer based Performance, Operation and Maintenance Management System (``POMMS``) consisting of four (4) modules (``Modules``). These Modules are used to monitor, evaluate and analyze the cost effective operation of simple cycle and combined cycle gas turbine power plants. Inputs to POMMS relating to plant performance, availability and maintenance are monitored, stored in a data acquisition system and analyzed to determine their impact on performance and cost parameters. POMMS was developed by EPRI, Project Manager Fluor Daniel Power Generation Company and by the subcontractors who, together, engineered the individual POMMS Modules while working on EPRI`s Durability Surveillance of Advanced Gas Turbines Project (``Project``). The following modules are described in this paper and may be applied together or individually: Rotating Blade Temperature ...
The Engineering and Technology Validation Team at the National Renewable Energy Laboratory (NREL) conducts in-situ technical evaluations of polycrystalline thin-film photovoltaic (PV) modules and arrays. This paper focuses on the technical evaluation of Solar Cells, Inc., (SCI) cadmium telluride (CdTe) module and array performance by attempting to correlate individual module and array performance. This is done by examining the performance and stability of the modules and array over a period of more than one year. Temperature coefficients for module and array parameters (P{sub max}, V{sub oc}, V{sub max}, I{sub sc}, I{sub max}) are also calculated.
A module is described with a receiver having a solar energy acceptance opening and supported by a mounting ring along the optic axis of a parabolic mirror in coaxial alignment for receiving solar energy from the mirror, and a solar flux modulator plate for varying the quantity of solar energy flux received by the acceptance opening of the module. The modulator plate is characterized by an annular, plate-like body, the internal diameter of which is equal to or slightly greater than the diameter of the solar energy acceptance opening of the receiver. Slave cylinders are connected to the modulator plate for supporting the plate for axial displacement along the axis of the mirror thereby shading the opening with respect to solar energy flux reflected from the surface of the mirror to the solar energy acceptance opening.
The Hazardous Materials Control Module (HMC) is one module of four for the Industrial Health component. The HMC module was designed to inform employees of health and safety hazards in the workplace and to track the movement of hazardous materials through the facility. The module performs these functions by maintaining health and safety data on hazardous materials used in the facility, and by tracking who requests information about any hazardous materials. The HMC module gets its information from two sources. The first one is the Hazardous Materials Information System (HMIS), this is a national system that is used by the Department of Defense. It is loaded on to the system via tapes that contain all safety, health and transportation information about a particular product. The second is Material Safety Data Sheets (MSDS) that are procured by a particular site. This information is ...
This research report for the Swiss Federal Office of Energy (SFOE) presents the results of a project that examined the feasibility of setting up 'MINERGIE' low-energy-consumption module standards for the production of heat in small residential buildings. The aims of the standards and the basic idea behind the MINERGIE-modules are discussed. The concepts of the modules for heat pumps and wood-fired heating systems and their combination with solar installations are examined, as are their areas of application. The requirements placed on the modules are listed. System concepts, including simple schematics for typical installations, are presented for wood-log, wood-chippings and pellets-fired systems as well as for ground-loop and air-water heat pump systems as well as their solar-aided counterparts. The results of cost-benefit analyses are presented and questions regarding system guarantee ...
SAMPSON is an integration of twelve analysis modules under the final development phase (phase-2) and will be capable of simulating hypothesized severe accidents in a nuclear power plant. One of these modules, the Molten Core Relocation Analysis (MCRA) module, simulates the relocation behavior of a molten core during a severe accident. MCRA models severe accident phenomena by using mechanistic formulations for multi-phase, multi-component, and multi-velocity field. As one of the verification studies of SAMPSON in Phase-1, the in-core phenomena of PHEBUS/FPT0 was analyzed with three modules, MCRA, fuel rod heat up analysis (FRHA) module, and the analysis control module (ACM) of SAMPSON. (author)
The GABA-modulating and GABA-mimetic activities of the monoterpenoid thymol were explored on human GABAA and Drosophila melanogaster...Full Text Available
We have measured the forward and reverse rates of the allosteric transition of hemoglobin A with three CO molecules bound by using modulated excitation coupled with fluorescence quenching of the DPG...Full Text Available
...this pathway study the following two focus modules (in addition to the six core modules) and carry out a research investigation within this theme: Agricultural Production Systems Considers the type of farming systems that have evolved globally in relation to the prevailing agro-climatic zones, the influences of economic factors ...
Many lifespan-modulating genes are involved in either generation of oxidative substrates and end-products, or their detoxification and removal. Among such metabolites, only lipoperoxides have the ability...Full Text Available
The ToxRS system in Vibrio cholerae plays a central role in the modulation of virulence gene expression in response to environmental stimuli. An integration of multiple signalling inputs...Full Text Available
This paper presents the design and implementation of a clinical picture archiving and communication system (PACS) module within the radiology department of a 700-bed teaching hospital. The system is...Full Text Available
This document describes testing and computation procedures used to generate a photovoltaic Module Energy Rating (MER). The MER consists of 10 estimates of the amount of energy a single module of a particular type (make and model) will produce in one day. Module energy values are calculated for each of five different sets of weather conditions (defined by location and date) and two load types. Because reproduction of these exact testing conditions in the field or laboratory is not feasible, limited testing and modeling procedures and assumptions are specified.
... concentrated on the construction of switches using fiber ... been chosen for a switch realized in ... of these techniques using acousto-optic modulators or ...
Purpose: To report outcomes of a single institution study of stereotactic body radiotherapy (SBRT) for unresectable cholangiocarcinoma. The dose-volume dependency of the observed gastrointestinal toxicity is explored. Methods and materials: Twenty-seven patients with unresectable cholangiocarcinoma (n = 26 Klatskin tumours and one intrahepatic cholangiocarcinoma (IHCC)) were treated by linac-based SBRT. The dose schedule was 45 Gy in three fractions prescribed to the isocenter. Results: The median progression-free survival and overall survival were 6.7 and 10.6 months, respectively. With a median follow-up of 5.4 years, 6 patients had severe duodenal/pyloric ulceration and 3 patients developed duodenal stenosis. Duodenal radiation exposure was higher in patients developing moderate to high-grade gastrointestinal toxicity with the difference in mean maximum dose to 1 cm"3 of duodenum reaching statistical significance. A statistically significant association between ...
We present an approach for fabrication of intentionally positioned epitaxial InAs QDs in a micron sized light emitting diode. For site-selective growth, a combination of molecular beam epitaxy (MBE) and focused ion beam (FIB) implantation technology in an all-ultra-high-vacuum (UHV) setup has been employed. Single dot occupancy of almost 55 % on FIB patterned nano-depressions was successfully achieved. Thereafter, carrier injection and subsequent radiative recombination from the positioned InAs/GaAs self-assembled QDs was investigated by embedding these QDs in the intrinsic part of a GaAs-based micron sized p-i-n junction device. Few or single dot are expected to be electrically addressed in these devices. We report results from electroluminescence (EL) measurement which proves the single dot characteristics of our device. The EL spectra consist of sharp emission lines and their dependence on injection current shows linear behavior for exciton ...
We study quasifinite highest weight modules over the supersymmetric extension of the W_1_+_#infinity# algebra on the basis of the analysis by Kac and Radul. We find that the quasifiniteness of the modules is again characterized by polynomials, and obtain the differential equations for highest weights. The spectral flow, free field realization over the (B, C)-system, and the embedding into gl(#infinity#vertical stroke #infinity#) are also presented. (orig.).
Based on the nonlinear dispersion relation of electromagnetic wave in relativistic plasma, the nonlinear controlling equation for linearly polarized mode is obtained using Karpman's method. The modulation instability of intense laser pulse propagating through relativistic plasma is analyzed and the modulation instability growth rate as a function of perturbation wave number for laser beam propagating through relativistic plasma is given. (authors)
The mz8310 device support module provides support for the following record types: event, pulseCounter, pulseDelay, and pulseTrain. No driver support is needed. Up to 4 mz8310 modules are supported. Each 8310 module contains 10 channels, which are identified as signals O,...9. Each channel is individually configurable. Each mz83 10 has two Am9513 Timing Controller chips. Each Am9513 has 5 counters.
Upgrading of oil palm empty fruit bunch (EFB), which is a main by-product of palm oil industry, to animal feeds by radiation pasteurization and fermentation was investigated for recycling the agro-resources and reducing the environmental pollution. The following results were obtained: 1) The necessary dose for pasteurization of EFB contaminated by various microorganisms including aflatoxin producing fungi was determined as 10 kGy. The chemical and biological properties of EFB were changed little by irradiation up to 50 kGy. 2) In the fermentation process, Pleurotus sajor-caju was selected as the most effective fungi and the optimum condition for fermentation was clarified. The process of fermentation in suspension was also established for the liquid seed preparation. 3) The digestibility and nutritional value of fermented products were evaluated as ruminant animal feeds and the mushroom can be produced as by-product. 4) The pilot plant named ...
We investigate some aspects of the radiation damage mechanisms in biomolecules, focusing on the modelling of resonant fragmentation caused by the attachment of low-energy electrons (LEEs) initially ejected by biological tissues when exposed to ionizing radiation. Scattering equations are formulated within a symmetry-adapted, single-center expansion of both continuum and bound electrons, and the interaction forces are obtained from a combination of ab initio calculations and a nonempirical model of exchange and correlation effects developed in our group. We present total elastic scattering cross-sections and resonance features obtained for the equilibrium geometries of glycine, alanine, proline and valine. Our results at those geometries of the target molecules are briefly shown to qualitatively explain some of the fragmentation patterns obtained in experiments. We further carry out a one-dimensional (1D) modeling for the dynamics of ...
The Sp-100 reactor is a lithium-cooled high-temperature fast-spectrum reactor. The fuel is UN. The cladding is fabricated from PWC-11, a Nb alloy, as are all the primary structural components. A reactor lifetime of up to ten years with an operating temperature of 1370 K is required. The accumulated fluence is expected to be 6 x10"2"2 n/cm"2. The damage, which could result in swelling or embrittlement, anneals out as fast as it occurs for the majority of the structure. This has been confirmed by earlier radiation testing. A number of components, however, are exposed to lower temperatures and the reactor design and materials selection for these components must take this into consideration. Radiation effects must also be considered for the UN fuel, bearing materials, etc. To data an instrumented experiment, MOTO 1000A, has been conducted in the FFTF reactor and as uninstrumented experiment SPM-1 in the EBR-II reactor. In this ...
The interference of hyperthermia and ionizing radiation, respectively, with the effects of capric (10:0), lauric (12:0), myristic (14:0), oleic (cis-18:1) and elaidic (trans-18:1) acids on the osmotic resistance of human erythrocytes was investigated. The results are summarized as follows: (A) not only at 37 degrees, but also at 42 and 47{degrees}C lauric acid (12:0) represents the minimum chain length for the biphasic behaviour of protecting against hypotonic hemolysis at a certain lower concentration range and hemolysis promotion at subsequent higher concentrations; (B) with increasing temperatures the protecting as well as the hemolytic effects occur at lower concentrations of the fatty acids; (C) the increase of temperature promotes the extent of hemolysis and reduces the extent of protection against hypotonic hemolysis; (D) Gamma-irradiation of erythrocytes selectively affects the concentration of oleic acid at which maximum protection ...
In the preparing stage of Final Safety Analysis Report (FSAR), the expected inventories of radwaste treatment systems are estimated. The inventory calculation plays an important role in the estimation of environmental radiation as well as nuclear power plant (hereafter referred to NPP) integrity, and further improvement of the public perception for NPP or radiation. The inventory has been accumulated and periodically measured for every NPP during the whole operation in Korea. But, a detailed analysis and database construction for the inventory have not still been carried out. For estimating the inventory change in this study, the radwaste treatment systems of Wolsung (hereafter referred to WS) nuclear power units 3 and 4 were selected as the reference systems. An analysis and prediction of the inventory change were performed for total activity released to environment during the whole operation. The linear regression ...
In the preparing stage of Final Safety Analysis Report (FSAR), the expected inventories of radwaste treatment systems are estimated. The inventory calculation plays an important role in the estimation of environmental radiation as well as nuclear power plant (hereafter referred to NPP) integrity, and further improvement of the public perception for NPP or radiation. The inventory has been accumulated and periodically measured for every NPP during the whole operation in Korea. But, a detailed analysis and database construction for the inventory have not still been carried out. For estimating the inventory change in this study, the radwaste treatment systems of Wolsung (hereafter referred to WS) nuclear power units 3 and 4 were selected as the reference systems. An analysis and prediction of the inventory change were performed for total activity released to environment during the whole operation. The linear regression ...
Background: The effective-dose method which was proposed by the ICRP (International Commission of Radiation Protection) for the estimation of risk to the general population from occupational or environmental, low-dose radiation exposure is not adequate for estimating the risk of cancer induction by radiotherapy of malignant or nonmalignant diseases. Methods:The risk of cancer induction by radiotherapy of benign diseases should be based on epidemiologic data directly derived from follow-up studies of patients who had been given radiotherapy for nonmalignant diseases in the past. Results: Risk factors were derived from epidemiologic studies of patients treated with irradiation for nonmalignant diseases to be used for selecting treatment options and optimizing treatment procedures. Conclusion: In most cases, cancer risks estimated by the effective-dose method may overestimate the true risks by one order of magnitude, yet in ...
Background: The effective-dose method which was proposed by the ICRP (International Commission of Radiation Protection) for the estimation of risk to the general population from occupational or environmental, low-dose radiation exposure is not adequate for estimating the risk of cancer induction by radiotherapy of malignant or nonmalignant diseases. Methods:The risk of cancer induction by radiotherapy of benign diseases should be based on epidemiologic data directly derived from follow-up studies of patients who had been given radiotherapy for nonmalignant diseases in the past. Results: Risk factors were derived from epidemiologic studies of patients treated with irradiation for nonmalignant diseases to be used for selecting treatment options and optimizing treatment procedures. Conclusion: In most cases, cancer risks estimated by the effective-dose method may overestimate the true risks by one order of magnitude, yet in ...
The efficacy of gamma irradiation as a method of decontamination for food and herbal materials is well established. In the present study, Glycyrrhiza glabra roots were irradiated at doses 5, 10, 15, 20 and 25 kGy in a cobalt-60 irradiator. The irradiated and un-irradiated control samples were evaluated for phenolic contents, antimicrobial activities and DPPH scavenging properties. The result of the present study showed that radiation treatment up to 20 kGy does not affect the antifungal and antibacterial activity of the plant. While sample irradiated at 25 kGy does showed changes in the antibacterial activity against some selected pathogens. No significant differences in the phenolic contents were observed for control and samples irradiated at 5, 10 and 15 kGy radiation doses. However, phenolic contents increased in samples treated with 20 and 25 kGy doses. The DPPH scavenging activity significantly (p<0.05) increased in ...
Fatty acid esters such as Lipiodol or Ethiodol are known to selectively localize in vascular hepatocellular carcinomas (HCC), following intraarterial hepatic administration. Lipiodol was labeled with radioactive /sup 131/I and administered in 47 patients with HCC for both imaging and therapy. The short term preliminary results suggest radiolabeled Lipiodol is effective in eliminating ascites, shrinking the tumor by a high internal radiation dose, and in improving symptomatology of these tumors. In the future, /sup 90/Y, which is a stronger pure beta-emitter (maximum beta energy of 2.27 MeV, a half life of 64 h, and a maximum penetration or beta range of 11mm), than /sup 131/I will be used for more effective treatment of HCC.
In this paper we present status and developments of the Duke storage ring facility. The Duke storage ring facility provides the unique combination of phase-locked light sources ranging from high power OK-4 XUV FEL to quasimonochromatic {gamma}-ray beam and IR/X-ray spontaneous radiation. The XUV OK-4 FEL, which is collaborative project with BlNP, Novosibirsk, is in operation since November, 1996. The OK-4 UV FEL is also used for production of nearly monochromatic {gamma}-ray s with tunable energy. We present the results of UV lasing with the OK4 FEL and selected results of its applications. We will discuss our future plans for extension of this source and status of the construction of dedicated used facility adjacent to the FEL building. (author)
We have performed extended X-ray absorption fine structure (EXAFS) analysis for artificial Cr-goethite to elucidate the local structure around Cr in Cr-goethite. The spectra were obtained using synchrotron radiation X-rays at the Photon Factory in Tsukuba. The first shell contributions were isolated by Fourier filtering EXAFS data, and the inverse Fourier transformed single-shell data were analyzed using a curve fitting method. The results show that Cr is coordinated with (7#+-#1)O"2"- ions. The protective characteristics of the Cr-goethite protective rust layer on weathering steel can be interpreted in terms of the O"2"- coordination around Cr"3"+ resulting in the creation of negative fixed charge in the Cr-goethite particles. (author)
In a fluoroscopic imaging system, image quality and patient dose are both affected by the optical system linking the image intensifier with the video camera. The effect on patient exposure of increasing the optical iris aperture size over that required for other procedures performed on the same imaging system was investigated for the air-contrast barium enema examination. Using a large-area transmission ionisation chamber to monitor the Roentgen-area-product of entrance exposure, a decrease in fluoroscopic radiation of greater than 50% was clinically documented for a fluoroscopic system utilising kVp and mA variable automatic brightness control. For this iris change, the video image was of acceptable quality for positioning and monitoring the patient, and no deleterious effect was detected in the conduct of the air-contrast exam. The availability of a variable-sized operator-selectable iris diaphragm would permit this dose-reduction approach to ...
Electron beam (EB) processing involves using electrons to initiate polymerization or cross-linking reactions in suitable substrates, thereby enhancing specific physical and chemical properties. A relatively new use of EB processing is now emerging: the production of fibre-reinforced composites. EB curing at ambient temperature has the potential to reduce the residual stresses in an advanced composite, a result of expansion during thermal curing, and to significantly increase the overall cure speed and process throughput. Wood fibres are used as a filler material for various thermoplastics such as polypropylene. EB treatment, combined with selected EB-curable coupling agents, significantly increases the adhesion between the wood fibres and the thermoplastic polymer, resulting in improved material properties. Work to develop both products and processes for the EB curing of fibre-reinforced composites is currently underway at AECL Research. This paper briefly updates ...
This study is an attempt to measure the quantities of elements in a composite by irradiating that composite with #gamma#-rays of various energies and detecting the transmitted radiation through the composite. A previous knowledge of the number of the elements and their attenuation coefficients is required. The quantities are calculated by solving the matrix of a linear system of equations. A computer program was developed to select the best combinations of the available energies. Five criteria were established to determine these energy combinations: (i) the determinant of the attenuation coefficient matrix; (ii) the condition number, (iii) the number of times the solution of the matrix leads to acceptable results; (iv) the indicator, (a new concept); (v) the standard deviations of the results. The intended application of this technique in medicine is to measure the bone mineral content of the skeleton. An examination of the error propagation, ...
We compute QCD corrections to the production of a ttbar pair in association with a hard photon at the Tevatron and the LHC. This process allows a direct measurement of the top quark electromagnetic couplings that, at the moment, are only loosely constrained. We include top quark decays, treating them in the narrow width approximation, and retain spin correlations of final-state particles. Photon radiation off top quark decay products is included in our calculation and yields a significant contribution to the cross-section. We study next-to-leading order QCD corrections to the ppbar -> ttbar+gamma process at the Tevatron for the selection criteria used in a recent measurement by the CDF collaboration. We also discuss the impact of QCD corrections to the pp -> ttbar+gamma process on the measurement of the top quark electric charge at the 14 TeV LHC.
Photoemission-electron-microscopy (PEEM) is introduced as a tool for the characterization of organic electronic devices. PEEM-measurements are used for imaging as well as for spectroscopic analyses by illumination with light of a Hg-lamp (4.9 eV), a D2 lamp (7.3 eV), and with synchrotron radiation for resonant photoelectron spectroscopy. We determine the charge carrier concentration inside the channel region of the organic device and its lateral distribution. From resonant photoelectron spectroscopy (RPES) we deduce the electronic states which are accessible with the Hg and D2 illumination. Photoelectron-spectroscopy at selected areas ({mu}-PES) gives information on the absolute values of surface potentials in lateral resolution. We are able to perform these studies with applied voltages at the source- and drain-electrode.
A glass heat pipe is adapted for use as a solar energy absorber in an evacuated tube solar collector and for transferring the absorbed solar energy to a working fluid medium or heat sink for storage or practical use. A capillary wick is formed of granular glass particles fused together by heat on the inside surface of the heat pipe with a water glass binder solution to enhance capillary drive distribution of the thermal transfer fluid in the heat pipe throughout the entire inside surface of the evaporator portion of the heat pipe. Selective coatings are used on the heat pipe surface to maximize solar absorption and minimize energy radiation, and the glass wick can alternatively be fabricated with granular particles of black glass or obsidian.
A plant for the fixation of high-level wastes in borosilicate glass has been operating in France since 1978. A large plant is under construction in the U.S. for the fixation of defence high-level waste and plans for other glass fixation plants are well advanced at several sites around the world. Among the reasons for the selection of borosilicate glass as a fixation medium are the relative ease of processing wastes of variable composition by means of well established technology, and the long-term radiation and thermal stability of the glass. Well formulated glass also has sufficient resistance to the action of groundwater so that it can serve as an important barrier against the spread of radionuclides via groundwater in any forseeable situation. Research is continuing to quantify the reactions of waste glass in site-specific geological repository environments.
This case study is an application, to a nuclear power plant, of the methodology for quantifying environmental costs and benefits, contained in the regional energy plan, adopted in April, 1983, by the Northwest Power Planning Council, pursuant to Public Law 96-501.The study is based on plant number 2 of the Washington Public Power Supply System (WNP-2), currently nearing completion on the Hanford Nuclear Reservation in eastern Washington State. This report describes and documents efforts to quantify and estimate monetary values for the following seven areas of environmental effects: radiation/health effects, socioeconomic/infrastructure effects, consumptive use of water, psychological/health effects (fear/stress), waste management, nuclear power plant accidents, and decommissioning costs. 103 references.
The major degradation mechanisms acting during the aging of selected WWER-440/213 primary circuit facilities were assessed critically. The analysis gave evidence that such mechanisms include radiation and fatigue damage of the reactor pressure vessel (effect of the neutron flow, cyclic fatigue promoted by the corrosive medium, effect of thermal aging), corrosion-mechanical and thermo-mechanical (fatigue) damage of the steam generator (stress corrosion cracking, erosion corrosion, thermal aging, wear), thermal and dynamic aging of the pressurizer, and corrosion-mechanical damage of the primary circuit piping (thermal aging, corrosion). (J.B.). 5 tabs., 1 fig., 62 refs.
Adaptive radiation therapy for liver cancer has the potential to reduce normal tissue complications and enable dose escalation, allowing the potential for tumor control in this challenging site. Using adaptive techniques to tailor treatment margins to reflect patient-specific breathing motions and image-guidance techniques can reduce the high dose delivered to surrounding normal tissues while ensuring that the prescription dose is delivered to the tumor. Several treatment planning and delivery techniques have been developed for use in the liver, including a margin to encompass the full breathing motion, mean position techniques, which evaluate the probability of tumor location during breathing, breath hold, gating, and tracking. Patient selection, clinical workflow, and quality assurance m...
With the advent of intensity-modulatedradiation therapy (IMRT), the inclusion of heterogeneity corrections is further complicated by the conformal delivery of many small beams forming steep dose gradients. Radiation treatment planning has evolved to take into account even small changes in tissue density so that the dose to tumor can be further optimized. However, different treatment planning systems incorporate different heterogeneity correction algorithms, and it is unclear whether any of these algorithms are superior to others in terms of accurately predicting delivered radiation doses relative to measurement in a clinical setting. The purpose of this study was to determine the accuracy of heterogeneity dose calculations from two widely used IMRT treatment planning systems (Pinnacle and Corvus) against measurement. These two systems handle heterogeneity dose corrections by means of a collapsed-cone ...
The radiation decimal reduction dose (D_1_0) of toxigenic Vibrio cholerae O1 El Tor, Inaba was determined in vitro (0.13 kGy) and in inoculated fresh fillets of saurel (Trachurus picturatus murphyi) (0.12 kGy) and another Pacific fish species known in Peru as ''lisa'', Mugil cephalus (0.13 kGy), both of which are frequently consumed raw in ''ceviche''. The D_1_0 value was similarly determined in tails of the shrimp species Penaeus vannamei (0.13 kGy). In a second phase of the study, radiation doses in the range 1.0-4.0 kGy were evaluated for use in microbiological shelf-life extension of the selected seafood, and for adverse effects on various sensory attributes (appearance, odor, flavor, and texture). A dose of 1.0 kGy doubled the microbiological shelf-life of fish fillets during post-irradiation storage at 0-1 deg. C to approximately 30 days. This dose was deemed optimal also for preserving all sensory characteristics ...
Purpose: Treatment results and the pattern of relapse were evaluated in the multimodal treatment of Ewing's sarcomas of the chest wall. Methods and Materials: In a retrospective analysis, 114 patients with non-metastatic Ewing's sarcoma of the chest wall were evaluated. They were treated in the CESS 81, CESS 86, or EICESS 92 studies between January 1981 and December 1993. The treatment consisted of polychemotherapy (VACA, VAIA, or EVAIA) and local therapy, either surgery alone (14 patients), radiotherapy alone (28 patients) or a combination of both (71 patients). The median follow-up was 46.6 months (range 5-170). A relapse analysis for all patients with local or combined relapses was performed. Results: Overall survival was 60% after 5 years, event-free survival was 50%. Thirty-seven patients had a systemic relapse (32.4%), 11 patients had a local relapse alone (9.6%), and 3 patients had a combined local and systemic relapse (2.6%). The risk to relapse locally after 5 years was 0% ...
Large-scale field tracer experiments have been conducted on Ulchin, Wolsung and Daeduk sites for the purpose of validating FADAS and of analyzing the environmental characteristics around the nuclear sites. The most influential factor in atmospheric dispersion is the meteorological condition. During the experiment, meteorological data were measured on the release point and the selected positions among sampling points. Once radioactive materials are released to the atmosphere, members of public may be exposed through the environmental media such as air, soil and foods. Therefore, to protect the public, adequate countermeasures should be taken at due time for those exposure pathways. both processes, of justification and optimization are applied to a countermeasure simultaneously for decision-making. The work scope of Biological research for the radiation protection had contained the search of biological microanalytic methods for assessing the ...
The absorption of solar heat and the attendant thermal and mechanical loadings on the tubes of cavity receivers depend predominantly on the flux distribution of the incident solar radiation. For an axially symmetric cavity receiver with a parabolic dish collector, it is simple to determine the insolation pattern on the receiver internal surfaces if the system is ideal. In such a system the surface of the dish is perfectly parabolic (no contour flaws are present), and the sun's central ray impinges on the dish surface parallel to the focal axis (no sun tracking flaws are present). These two conditions cannot be achieved in practice, and therefore the feasible parabolic dish system is referred to as a real system although, in actual fact, it is only an approximation to any actual system. The purpose of this paper is to devise calculation principles which permit analysis of a receiver designed for ideal conditions to verify its structural adequacy under the ...
In order to qualify corrosion resistant materials for high level waste (HLW) packagings acting as a long-term barrier in a rock salt repository, the corrosion behaviour of the preselected materials Ti 99.8-Pd, Hastelloy C4 and two unalloyed steels was investigated. The resistance of the materials to general corrosion, local corrosion and stress corrosion cracking was examined under postulated accident conditions in the repository by long-term immersion tests of up to 4 years duration and electrochemical methods. The parameters investigated were different salt brines, temperatures of 90 deg. C, 170 deg. C and 200 deg. C as well as a gamma radiation field of 10"3Gy/h (10"5rad/h). Among the materials studied, Ti 99.8-Pd exhibited the highest corrosion resistance. This material corroded at a very low rate (radiation, and proved to be resistant to local corrosion and stress corrosion cracking. Hastelloy C4 ...
An all solid-state kicker pulser for a proton radiography system has been designed. Multiple solid-state modulators stacked in an inductive-adder configuration are utilized in this kicker pulser design. Each modulator is comprised of multiple metal-oxide-semiconductor field-effect transistors (MOSFETs) which quickly switch the energy storage capacitors across a magnetic induction core. Metglas is used as the core material to minimize loss. Voltage from each modulator is inductively added by a voltage summing stalk. A circuit model of a prototype inductive adder kicker pulser modulator has been developed to predict the performance of the pulser modulator. The modeling results are compared with experimental data.
Summary Metabotropic GABAB receptors play a fundamental role in modulating the excitability of neurons and circuits throughout the brain. These receptors influence synaptic transmission by inhibiting presynaptic release or activating postsynaptic potassium channels. However, their ability to directly influence different types of postsynaptic glutamate receptors remains unresolved. Here we examine GABAB receptor modulation in layer 2/3 pyramidal neurons from the mouse prefrontal cortex. We use two-photon laser-scanning microscopy to study synaptic modulation at individual dendritic spines. Using two-photon optical quantal analysis, we first demonstrate robust presynaptic modulation of multivesicular release at single synapses. Using two-photon glutamate uncaging, we then reveal that GABAB r...
Abstract The authors provide a survey of how images are used in radiation therapy to improve the precision of radiation therapy plans, and delivery of radiation treatment. In contrast...Full Text Available
... radiation during clinical therapy and exposures due to radiation accidents or attacks, in which the doses are uncontrolled ... only be used off-label in victims of radiation accidents or attacks. The idea...
Four 10 MW, highly-stabilized power supply modules have been installed at the National High Magnetic Field Laboratory in Tallahassee, FL, to energize water-cooled, resistive, high-field research magnets. The power supply modules achieve a long term current stability if 10 ppM over a 12 h period with a short term ripple and noise variation of <10 ppM over a time period of one cycle. The power supply modules can operate independently, feeding four separate magnets, or two, three or four modules can operate in parallel. Each power supply module consists of a 12.5 kV vacuum circuit breaker, two three-winding, step-down transformers, a 24-pulse rectifier with interphase reactors, and a passive and an active filter. Two different transformer tap settings allow rated dc supply output voltages of 400 and 500 V. The rated current of a supply module is 17 kA and each ...
The DOE-Idaho Operations Office (DOE-ID) has prepared an environmental assessment (EA) on the replacement of the Idaho National Engineering Laboratory Health Physics Instrumentation Laboratory at the Idaho National Engineering Laboratory (INEL). The purpose of this project is to replace the existing Health Physics Instrumentation Laboratory (HPIL) with a new facility to provide a safe environment for maintaining and calibrating radiation detection instruments used at the Idaho National Engineering Laboratory. The existing HPIL facility provides portable health physics monitoring instrumentation and direct reading dosimetry procurement, maintenance and calibration of radiation detection instruments, and research and development support-services to the INEL and others. However, the existing facility was not originally designed for laboratory activities and does not provide an adequate, safe environment for calibration activities. The EA examined ...
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and has very limited therapeutic options. Recently, it has been found that hyaluronic acid (HA) shows selective binding to CD44 receptors expressed in most cancer histotypes. Since the trend in cancer treatment is the use of targeted radionuclide therapy, the aim of this research was to label HA with rhenium-188 and to evaluate its potential use as a hepatocarcinoma therapeutic radiopharmaceutical. Methods: {sup 188}Re-HA was prepared by a direct labelling method to produce a ReO(O-COO){sub 2}-type coordination complex. {sup 188}Re-HA protein binding and its stability in saline, phosphate buffer, human serum and cysteine solutions were determined. Biokinetic and dosimetric data were estimated in healthy mice (n=60) using the Medical Internal Radiation Dose methodology and mouse model beta-absorbed fractions. To evaluate liver toxicity, alanine aminotranferase (AST) and ...
Because every cell within the body has the same genetic information, a significant problem in biology is to understand how cells within a tissue express genes selectively. A sophisticated network of physical and biochemical signals converge in a highly orchestrated manner to bring about the exquisite regulation that governs gene expression in diverse tissues. Thus, the ultimate decision of a cell to proliferate, express tissue-specific genes, or apoptose must be a coordinated response to its adhesive, growth factor, and hormonal milieu. The unifying hypothesis examined in this overview is that the unit of function in higher organisms is neither the genome nor the cell alone but the complex, three-dimensional tissue. This is because there are bidirectional connections between the components of the cellular microenvironment (growth factors, hormones, and extracellular matrix) and the nucl2048 These connections are made via membrane-bound receptors and transmitted to ...
A unified Nonhydrostatic Multiscale Model on the Arakawa B grid (NMMB) designed for a broad range of spatial and temporal scales has been under development within the Earth System Modeling Framework (ESMF) at the National Centers for Environmental Prediction (NCEP) as a part of the new National Environmental Modeling System (NEMS). The model follows the general modeling philosophy of the NCEP's WRF NMM grid-point regional dynamical core. The model uses the regular latitude-longitude grid for the global domain, and a rotated latitude-longitude grid in regional applications. The nonhydrostatic component of the model dynamics is introduced through an add-on module that can be turned on or off depending on resolution. The "isotropic" quadratic conservative finite-volume horizontal differencing employed in the model conserves a variety of basic and derived dynamical and quadratic quantities and preserves some important properties of differential operators. Among these, ...
Purpose: Patients with ataxia-telangiectasia (A-T) show greatly increased radiation sensitivity and cancer predisposition. Family studies imply that the otherwise clinically silent heterozygotes of this autosomal recessive disease run a 3.5 to 3.8 higher risk of developing cancer. In vitro studies suggest moderately increased cellular radiation sensitivity of A-T carriers. They may also show elevated clinical radiosensitivity. We retrospectively examined patients who presented with severe adverse reactions during or after standard radiation treatment for mutations in the gene responsible for A-T, ATM, considering a potential means of future identification of radiosensitive individuals prospectively to adjust dosage schedules. Material and Methods: We selected 20 cancer patients (breast, 11; rectum, 2; ENT, 2; bladder, 1; prostate, 1; anus, 1; astrocytoma, 1; Hodgkins lymphoma, 1) with Grade 3 to 4 ...
A mesoscopically ordered lamellar gel phase of a polymer-grafted, lipid-based complex fluid is used as a scaffolding to spatially organize inorganic nanoparticles. The complex fluid provides both a highly anisotropic environment and a segregated aqueous and organic domains in which inorganic nanoparticles can be selectively placed by tailoring their size and surface characteristics. Three types of silver nanoparticles -- underivatized, surfactant-stabilized, and dodecanthiol-derivatized -- were evaluated. Comparison of the surface plasmon resonance of the various silver particles dispersed in conventional solvents to those contained within the complex fluid was used to determine the region of spatial localization in the lamellar gel phase. Silver particles rendered hydrophobic by capping with an alkane thiol insert into the hydrocarbon bilayer region. Surfactant-stabilized and underivatized silver nanoparticles reside in the aqueous channels, with the latter ...
This paper presents a technical feasibility study project for the large scale rooftop photovoltaics (PV) grid connected system at Charoenphol-Rama I green building super store of TESCO LOTUS (TL) in Thailand. The objective of this project is (i) to study the technical feasibility of installation 350 kWp PV systems on the top of the roof in this site (ii) and to determine the energy produce from this system. The technical factors are examined using a computerized PVS 2000 simulation and assessment tool. This super store building located in Bangkok, with latitude 14 N, longitude 100 E and the building direction is 16 from North direction. The building roof area is 14,000 m2; with 3 degree face East and 3 degree face West pitch. Average daily solar energy in this area is approximately 5.0 kWh. The study team for this project consists of educational institution as School of Renewable Energy Technology (SERT) and private institution as Panya Consultants (PC). TL is the project owner, PC is ...
Hox genes encode a family of transcriptional regulators that operate differential developmental programs along the anteroposterior axis of bilateral animals. Regulatory changes affecting Hox gene expression are believed to have been crucial for the evolution of animal body plans. In Drosophila melanogaster, Hox expression is post-transcriptionally regulated by microRNAs (miRNAs) acting on target sites located in the 3' untranslated regions (3'UTRs) of Hox mRNAs. Notably, recent work has shown that during D. melanogaster development Hox genes produce mRNAs with variable 3'UTRs (short and long forms) in different sets of tissues as a result of alternative polyadenylation; importantly, Hox short and long 3'UTRs contain very different target sites for miRNAs. Here, we use a computational approach to explore the evolution of Hox 3'UTRs treated with especial regard to miRNA regulation. Our work is focused on the 12 Drosophila species for which genomic sequences are available and shows, ...
The computer program is developed based on Visual C++, which is equipped with a user-friendly interface of the input/output(I/O) and a display function for the measuring conditions. This program consists of three parts which are the port communication, PLC(Programmable Logic Controller) and the MCA(Multi Channel Analyzer) control parts. The communication type between the CPU of the PLC module box and the computer is selected as be the Rs-232 asynchronous type and the thread method is adapted in the development of the first part of the program. The PLC-related program has been developed so that the data communication between the PLC CPU and the computer could be harmonized with the unique commands which have already been defined in the PLC. The measuring space and time intervals, the start and end ROI(region of interest) values, and the allowable error limitation are input at each measurement in this program. Finally the controlling MCA program ...
Background and purpose: To compare 6 MV and 18 MV photon intensity modulated radiotherapy (IMRT) for non-small cell lung cancer. Materials and methods: Doses for a cohort of 10 patients, typical for our department, were computed with a commercially available convolution/superposition (CS) algorithm. Final dose computation was also performed with a dedicated IMRT Monte Carlo dose engine (MCDE). Results: CS plans showed higher D _9_5_% (Gy) for the GTV (68.13 vs 67.36, p = 0.004) and CTV (67.23 vs 66.87, p = 0.028) with 18 than with 6 MV photons. MCDE computations demonstrated higher doses with 6 MV than 18 MV in D _9_5_% for the PTV (64.62 vs 63.64, p = 0.009), PTV_o_p_t_i_m (65.48 vs 64.83, p = 0.014) and CTV (66.22 vs 65.64, p = 0.027). Dose inhomogeneity was lower with 18 than with 6 MV photons for GTV (0.08 vs 0.09, p = 0.007) and CTV (0.10 vs 0.11, p = 0.045) in CS but not MCDE plans. 6 MV photons significantly (D _3_3_%; p = 0.045) spared the esophagus in MCDE ...
NuEra Oilfield Services Inc. combines various technologies, including advanced bearing assemblies and compact wireless decoders that interface with downhole directional tools, to engineer unique, purpose-built measurement-while-drilling (MWD) tool string packages. The 9-metre-long MWD tool string is lowered into the drill pipe from the surface. The directional module monitors the position of the drill bit, which the driller can monitor using an electronic drilling recorder at the surface. The directional drillstring uses a mud motor with adjustable bent housing to correct the direction of the well, as the system cannot steer while drilling. At bottomhole, mud circulation continues after the rotation of the drillstring has been stopped, driving the mud motor, which in turn drives the drill bit, permitting a new direction to be taken even though the drillstring is not turning. The operator points the bent housing in a new direction and slides the bit along before ...
A balloon-borne instrument has measured the cosmic-ray antiproton flux between 130 and 320 MeV and searched for antihelium between 130 and 370 MeV per nuclear. These particles were selected from the background of normal-matter cosmic rays by combining a selective trigger with a detailed spark chamber visualization of each recorded event. Antiprotons are identified by their characteristic annihilatin radiation. Residue from background processes meeting the selection criteria is small. The observed 14 antiprotons yield a measured differential flux of 1.7 +- 0.5 x 10/sup -4/ antiprotons m/sup -2/ sr/sup -1/ s/sup -1/ MeV/sup -1/ at the top of the atmosphere. The corresponding antiproton/proton ratio is 2.2 +- 0.6 x 10/sup -4/,, only slightly smaller than the ratio observed by other experiments at higher energies. Thus the antiprotons have a spectral shape similar to the protons, at least down to about 100 ...
Ellipsometric studies and reflectance measurements on five anodized coloured 304 stainless steel samples (Brown, Violet, Blue, Light Grey and Dark Grey) are reported. The optical properties, solar absorptance and thermal emittance of samples have been obtained. Measured values of absorptance lay between 0.75-0.87 together with a near normal emittance value approx. =0.10 at 100/sup 0/C. The total hemispherical emittance has been measured at 100 and 200/sup 0/C for the sample having the best selective surface. This study shows that the blue coloured surface has the most favourable combination of radiation properties. The surface deteriorates at temperatures above 210/sup 0/C. Oxidation is assumed to be the deterioration mechanism. The different samples exhibited difference in the /PSI/ and ..delta.. parameters as determined by ellipsometry both before and after heat treatments. When brown and violet samples were coated with a 125 nm layer of ...
The Fermi National Laboratory (Fermilab) operates the Tevatron proton-antiproton collider at a center-of-mass energy of {radical}s = 1.96 TeV, the is therefore the only collider which is today able to produce the heaviest known particle, the top quark. The top quark was discovered at the Tevatron by the CDF and D0 collaborations in 1995. At the Tevatron, most top quarks are produced via the strong interaction, whereby quark-antiquark annihilation dominates with 85%, and gluon fusion contributes with 15%. Considering next-to-leading order (NLO) contributions in the cross section of top-antitop quark production, leads to a slight positive asymmetry in the differential distribution of the production angle {alpha} of the top quarks. This asymmetry is due to the interference of certain NLO contributions. The charge asymmetry A in the cosine of {alpha} is predicted [14] to amount to 4-6%. Information about the partonic rest frame, necessary for a measurement of A in the observable cos ...
The case of spontaneous radiation of channeled ultrarelativistic particles is considered when the dipolarity condition is not satisfied. The change of the particle longitudinal velocity affecting the maximum radiation frequency is included. The angular and frequency characteristics of the radiation for superhigh energies are studied for the first time. It is shown that there is an optimum energy at which the radiation density is maximum. The influence of the angle at which electrons enter a crystal and of the beam divergence on the radiation is investigated. The problem of quasichanneled particle radiation and also the radiation in axis-plane transitions are considered. (author).
An add-on multileaf collimator for electrons (eMLC) has been developed that provides computer-controlled beam collimation and isocentric dose delivery. The design parameters result from the design study by Gauer et al (2006 Phys. Med. Biol. 51 5987-6003) and were configured such that a compact and light-weight eMLC with motorized leaves can be industrially manufactured and stably mounted on a conventional linear accelerator. In the present study, the efficiency of an initial computer-controlled prototype was examined according to the design goals and the performance of energy- and intensity-modulated treatment techniques. This study concentrates on the attachment and gantry stability as well as the dosimetric characteristics of central-axis and off-axis dose, field size dependence, collimator scatter, field abutment, radiation leakage and the setting of the accelerator jaws. To provide isocentric irradiation, the eMLC can be placed either 16 or ...
A prototype for a quasi-cw, and high-average power free electron laser (FEL) driven by a 15 MeV superconducting rf linac has been developed, and constructed at Tokai, JAERI since 1989. Cryogenic and accelerating fields' performances of four JAERI superconducting accelerator modules have been realized without any serious problem in the FEL accelerator vault and experimental hall. Since modification and related maintenance of the cryogenic refrigerator system for the driver were completed in the middle of October 1995, the system has run with no trouble, and the driver has been continuously run very successfully up to now. The optical resonator system and related electron beam transport system have been modified to realize larger acceptance than the old for both of the undulator radiation and energetic electron beam in 1995 Japanese fiscal year. In the modification, an alignment and distance measurement system has been newly developed, and ...
The main objective of the present thesis was develop and get operational a real-time neutron radiography system, at the IPEN-CNEN/SP. This system is installed inside the shielding of an old facility, designed in 1988, for film radiography, which is installed at the beam-hole 08 of the 5 MW, IEA-R1 Nuclear Research Reactor. The most important modifications at the such facility were the increase of the {gamma}-radiation filter thickness, increase of the inner area of the shielding, design of a neutron collimator and a light tight box. The main characteristics of the neutron beam at the irradiation position are: flux: 1 x 10{sup 6}n/cm{sup 2}s, collimation ratio 70, effective energy 7 meV, diameter 20 cm, neutron/{gamma} ratio {approx} 10{sup 6}n/cm{sup 2}mrem. The real-time images have been obtained by means of an imaging system that consists of a screen scintillator, a light intensifier, a video camera, a digitizing frame grabber and a computer. The device composed ...
The main objective of the present thesis was develop and get operational a real-time neutron radiography system, at the IPEN-CNEN/SP. This system is installed inside the shielding of an old facility, designed in 1988, for film radiography, which is installed at the beam-hole 08 of the 5 MW, IEA-R1 Nuclear Research Reactor. The most important modifications at the such facility were the increase of the #gamma#-radiation filter thickness, increase of the inner area of the shielding, design of a neutron collimator and a light tight box. The main characteristics of the neutron beam at the irradiation position are: flux: 1 x 10"6n/cm"2s, collimation ratio 70, effective energy 7 meV, diameter 20 cm, neutron/#gamma# ratio #approx# 10"6n/cm"2mrem. The real-time images have been obtained by means of an imaging system that consists of a screen scintillator, a light intensifier, a video camera, a digitizing frame grabber and a computer. The device composed by the scintillator ...
The Anisotropic Analytical Algorithm (AAA) is a new pencil beam convolution/superposition algorithm proposed by Varian for photon dose calculations. The configuration of AAA depends on linear accelerator design and specifications. The purpose of this study was to investigate the accuracy of AAA for an Elekta SL25 linear accelerator for small fields and intensity modulatedradiation therapy (IMRT) treatments in inhomogeneous media. The accuracy of AAA was evaluated in two studies. First, AAA was compared both with Monte Carlo (MC) and the measurements in an inhomogeneous phantom simulating lung equivalent tissues and bone ribs. The algorithm was tested under lateral electronic disequilibrium conditions, using small fields (2x2 cm"2). Good agreement was generally achieved for depth dose and profiles, with deviations generally below 3% in lung inhomogeneities and below 5% at interfaces. However, the effects of attenuation and scattering close to ...
In cooperation with NRPB, the specifications of the mainframe COSYMA version 95/1 and the PC COSYMA version 2.0 were prepared and the corresponding modifications implemented. Important improvements are dose-rate dependent models for deterministic health effects, the time dependent efficiency of stable iodine tablets, the extension of data bases for the inclusion of activation products, and supplementary evaluation programs. PC COSYMA has been completed by an economics module, further options in the ingestion pathways, and a graphics package for presenting assessment results. COSYMA has been applied for probabilistic dose assessments within paramter studies and special investigations of EPR concepts. RODOS, the real-time on-line decision support system for nuclear emergency management, has been further developed with the aim of the first pilot version 2.0 for pre-operational application in the second half of 1995. At present, some 20 institutes in the EU, 8 ...
We describe the development of a fully coupled climate model configuration where the Community Climate System Model (CCSM) has been coupled with the VERDE (Visualizing Energy Resources Dynamically on the Earth) analysis modules that compute the response of the electric grid to temperature drivers. The VERDE model includes datasets characterizing the 26,500 sub-stations and 6,000 power generation stations fuel mix, efficiency, service areas, and future performance and these have been geo-located on a 1.4 degree latitude by 1.4 degree longitude CCSM grid (T85). The total electric customers have been computed using conversions derived from economic structure and population data. The carbon emissions per customer and the power generation in megawatts electric (MWe) have also been placed on reconciled 1 km, 4 km and the T85 climate model grid. The CCSM temperature for the present and future have been extracted from the climate model output and placed on the same grid as ...
The object of this paper is to identify the key elements that impact a radiation dose at EAB (Exclusion Area Boundary). This study is based on the AST (Alternative Source Terms) as defined in Regulatory Guide 1.183. The LOCA (Loss of Coolant Accident) and the LRA (Locked Rotor Accident) are selected as limiting cases. A sensitivity analysis of accidental behavior with respect to various parameters during LOCA and LRA at Kori Unit 1 is also undertaken for the following objectives: to determine the limiting parameters, to find the impact trend of the radiation dose, and to find the safety margin between AST and TID (Technical Information Document) methodologies. This work confirms that key parameters are particulate removal rate, decontamination factor, iodine chemical form, gap fraction, partitioning factor, and the impact of isotopes group. Comparing TID with AST, the radiation dose of TID is about 80% ...
The late effects of "2"3"9Pu have been studied after its administration to perinatal, juvenile and adult rats. Adults and weanlings were injected intravenously, newborns intracardially and 19-day foetuses by intravenous injection of the dam. Dose levels were selected to deliver radiation doses of approximately 7, 23, or 70 rads to the femur of all ages during the first 10 days post injection; in general these values were achieved as shown by tissue analysis. Dose rates subsequently diverged, resulting in widely varying cumulative radiation doses for the four age groups. Survival times of rats exposed post-natally were progressively decreased by increasing dose. No decrement in survival was found for those exposed prenatally. Bone tumour incidence was increased by exposure to Pu in all age groups. The younger rats were less sensitive on an administered dose basis, but perhaps more sensitive on the basis of cumulative ...
Systematics of neutron capture radiative width were studied in the target element range from Th to Cm. Reduced radiative widths were analyzed with a simple radiative width formula based on E1 transition. Average radiative width is presented with the standard deviation of 15%. (author)
This paper proposes an optimization algorithm to reduce the distortion produced in the loop-filter of Continuous-Time Sigma-Delta Modulators. The aim of the algorithm is to find the loop-filter implementation that minimizes distortion at the output of the modulator, by modifying the output swing of every integrator. The algorithm is implemented in Matlab as an evolutive searching. During each step of the searching, the algorithm evaluates the harmonical distortion of a tone when it is applied to the modulator with a certain loop-filter implementation. The output of the algorithm is an optimum linear state-space representation of the loop-filter. This particular state-space representation leads to minimum distortion at the output of the modulator when the loop-filter is implemented with some specific circuitry previously defined. As long as the search is of evolutive type, the solution represents a local ...
What kind of hardware and software should be used to interface GPIB devices with the existing computer system. One idea was to use a commercially available Multibus card, BLC 8488 from National Semiconductor, whose on-board Z80 would manage the GPIB read/write functions and handshakes. With this card, one could make a hardware system which would consist of (1) CAMAC 080, (2) Multibus crate, (3) M. Shea's M68000, (4) M080, (5) BLC 8488 and (6) memory board. And the software considered for such a hardware package was GAS, which had been an established software package for communication between the ACNET computer system and smart CAMAC modules. However, a second idea was to put everything on a two-wide CAMAC module. The author pursued the second idea and came up with a two-wide CAMAC module called C488. The author describes the hardware - block diagrams, circuit blocks, front panel and hardware tests. He also refers ...
A plan to diffuse instructional modules for the preparation of transportation professionals is presented, based on research and demonstration projects sponsored by the Urban Mass Transportation Administration (UMTA). The diffusion/adoption plan involves: developing instructional modules; disseminating the modules to professors teaching transportation courses at the college level; promoting the use and adoption of the modules; and evaluating and revising the plan. Transportation educators teach in a variety of disciplines (e.g., engineering, public administration, urban planning, and technology). Eight design and evaluation criteria for the instructional modules are listed, along with the procedures used by West Virginia University in developing the five instructional modules. The diffusion strategy involves repackaging UMTA research findings, change agents, and ...
In this paper, an approximate curve fitting method for photovoltaic modules is presented. The operation is based on solving a simple solar cell electrical model by a microcontroller in real time. Only four voltage and current coordinates are needed to obtain the solar module parameters and set its operation at maximum power in any conditions of illumination and temperature. Despite its simplicity, this method is suitable for low cost real time applications, as control loop reference generator in photovoltaic maximum power point circuits. The theory that supports the estimator together with simulations and experimental results are presented. (author)
The General Purpose Light Source VME module is an integral part of every front-end micro in the NSLS control system. The board incorporates features such as a video character generator, clock signals, time-of-day clock, a VME bus interrupter and general-purpose digital inputs and outputs. This module serves as a valuable diagnostic and real-time display tool for the micro development as well as for the final operational systems. This paper describes the functions provided by the board for the NSLS micro control monitor software.
A fiber optic feedthrough module which comprises a metal sleeve, a fiber optic element extending through the sleeve in spaced relation thereto, and a tandem series of centrally-apertured mating annular sealant bodies of thermoplastic material surrounding the fiber optic element and compressed between it and the sleeve. The module is made by first providing a loose subassembly of a plurality of individual but interfitting sealant bodies on the fiber optic element and then inserting this subassembly into a metal sleeve, following by swaging the whole assembly which eliminates clearances and provides sealed interfaces between the various contacting components. (author).
The expected interstellar antiproton spectrum arising from cosmic-ray interactions in the Galaxy is recalculated, and the modulation of both antiprotons and protons is calculated using a two-dimensional modulation model incorporating gradient and curvature drifts and a wavy current sheet as well as the usual diffusion, convection, and energy-loss effects. Significant differences in the antiproton/proton ratio for different solar magnetic field polarities are predicted as well as a 'low-energy' component for antiprotons below about 1 GeV. 28 refs.
Collection, analysis and quantification of human factor data are important compositions of human reliability analysis (HRA) and probabilistic risk assessment (PRA). Various human factor databases have been set up, but there are comparatively little human factor data management systems which can be uses for collection, classification, analysis, calculation and predication of the human factor data. Therefore, the human factor data management system for Daya Bay NPP is developed, with the following three modules and four databases: original data module, computing module, introduced data module, and basic database, other data source of the plant, external database and introduced database. The foundational problems about human factor data and the systemic structure and function are described. The data structure in the database is also discussed, because it is of the most importance in the system
The in vivo photochemical activity of photosystem II was inferred from modulated chlorophyll fluorescence and photoacoustic measurements in intact leaves of several plant species (Lycopersicon...Full Text Available
... 36 7 Corrugated Steel Pipe Concept Layout--Elevation ..... 37 viii ... revetment. 3. Land Use ... Corner modules and capping blocks are available. ...
There is considerable evidence that purines are vasoactive molecules involved in the regulation of blood flow. Adenosine is a well known vasodilator that also acts as a modulator of the response to...Full Text Available
The purpose of this study is to explain the unplanned longitudinal dose modulations that appear in helical tomotherapy (HT) dose distributions in the presence of irregular patient breathing....Full Text Available
The steroidal regulation of vertebrate neuroanatomy and neurophysiology includes a seemingly unending list of brain areas, cellular structures and behaviors modulated by these hormones. Estrogens,...Full Text Available
... modules 2 and 3, 45 ft from each end) in a ... The toe of the stone revetment was 2 ft out from the ... in parentheses are for the current meters in layout 2. ...
... revetment construction, water well drilling, mobile facility assets construction using ... five days, and establish site layout for the follow-on RH ... modules. ...
Temperature is an important modulator of longevity and aging in both poikilotherms and homeotherm animals. In homeotherms, temperature homeostasis is regulated primarily in the preoptic area...Full Text Available
In the rf-driven free-electron laser (FEL) at the Los Alamos National Laboratory, there are two pulsed-power rf modulators as sources for two tandem, side-coupled 20-MeV linear accelerators. The rf power used to control the cavity fields is supplied by two 5.5-MW modulating anode klystrons operating at a center frequency of 1300.2 MHz. The modulation of the 125 kV klystron is achieved by using a triode switch tube that provides a pulse width up to 300 ..mu..s and a pulse repetition rate up to 10 Hz. This paper describes the present configuration of these two duplicate systems and presents plans for meeting the requirements of future rf FEL experiments at Los Alamos. 12 refs., 5 figs.
This Guideline provides a set of procedures for the measurement of organic contaminants and particles in producer gases from biomass gasifiers. The procedures are designed to cover different gasifier types (updraft or downdraft fixed bed or fluidised bed gasifiers), operating conditions (0 - 900C and 0.6-60 bars) and concentration ranges (1 mg/m{sub n}{sup 3} to 300 g/m{sub n}{sup 3}). The Guideline describes a modular sampling train, and a set of procedures, which include: planning and preparation of the sampling, sampling and post-sampling, analysis, calculations, error analysis and reporting. The modular sampling train consists of 4 modules. Module 1 is a preconditioning module for isokinetic sampling and gas cooling. Module 2 is a particle collection module including a heated filter. Module 3 is a tar collection module with a gas quench ...
Glucagon plays critical roles in regulating glucose homeostasis, mainly by counteracting the effects of insulin. Consequently, the dysregulated glucagon secretion that is evident in type 2 diabetes has significant implications in the pathophysiology of the disease. Glucagon secretion from pancreatic -cells has been suggested to be modulated by blood glucose, signals from the nervous system and endocrine components. In addition to these regulators, intraislet factors acting in a paracrine manner from neighbouring -cells are emerging as central modulator(s) of -cell biology. One of the most important of these paracrine factors, insulin, modulates glucagon secretion. Indeed, the -cell-specific insulin receptor knockout (IRKO) mouse manifests hypersecretion of glucagon in the postprandial stag...
was deemed adequate and a cooling system designed utilizing the Melcor CP2-15- 10B thermoelectric module. Wall temperature achieved with this system was - 36 ...
With the ubiquitous availability of commercial VME modules and interface chips many experiments in all branches of Experimental Physics are turning to VME as the module packaging and backplane protocol of choice for application specific modules. The current VME backplane, electrical, and mechanical standards are clearly lacking when it comes to implementing the analogue and digital front end modules that Physics experiments rely on to provide the needed high speed and intelligent solutions to their data collection requirements. To address these needs the European ESONE and American VME-P committees are collaborating with the ANSII and ISO standards committees, and the VME VITA/VSO manufacturers associations, to define standard extensions to the VME protocols for such HEP needs as ``sparse data scans``, standard uses and implementations of previously user defined pins and connectors, standardization of ...
An important growth in the power of the photovoltaic systems connected to a grid has recently been observed. In spite of the advances in module technology, the problems in the system design increased, especially regarding the surface of the earth they occupy. In this work we propose a complete model for plant simulation with different wiring diagrams and under dynamic shading. Results obtained from simulations showed that the configuration with the lowest performance was that of only one serial-parallel group, whereas the highest efficiency corresponded to a design of groups of modules in parallel connected then in series. In general, a higher efficiency was obtained diminishing the quantity of modules in series and increasing their number in parallel. The simulation model proposed allows exploring different alternatives of wiring modules and finding the most efficient configurations for photovoltaic ...
The Four years of the IMPACT, 'Integrated Modular Plant Analysis and Computing Technology' project Phase 1 have been completed. The verification study of Severe Accident Analysis Code SAMPSON prototype developed in Phase 1 was conducted in two steps. First, each analysis module was run independently and analysis results were compared and verified against separate-effect test data with good results. Test data are as follows: CORA-13 (FZK) for the Core Heat-up Module; VI-3 of HI/VI Test (ORNL) for the FP Release from Fuel Module; KROTOS-37 (JRC-ISPRA) for the Molten Core Relocation Module; Water Spread Test (UCSB) for the Debris Spreading Model and Benard's Melting Test for Natural Convection Model in the Debris Cooling Module; Hydrogen Burning Test (NUPEC) for the Ex-Vessel Thermal Hydraulics Module; PREMIX, PM10 (FZK) for the Steam Explosion ...
Code coupling activities have so far focused on coupling the neutronics modules with the CFD module. An interface module for the CFD-ACE/DeCART coupling was established as an alternative to the original STAR-CD/DeCART interface. The interface module for DeCART/CFD-ACE was validated by single-pin model. The optimized CFD mesh was decided through the calculation of multi-pin model. It was important to consider turbulent mixing of subchannels for calculation of fuel temperature. For the parallel calculation, the optimized decompose process was necessary to reduce the calculation costs and setting of the iteration and convergence criterion for each code was important, too.
switch when this cavity matching condition is determined. This results is a ... MHz offset is provided by an acousto-optic modulator. (AOM). The AOM will be shut ...
The pleiotropic actions of neuromodulators on pre- and postsynaptic targets present challenges to disentangling the mechanisms underlying regulation of synaptic transmission. Within the striatum,...Full Text Available
CAAX proteins are widely involved in global cellular functions such as proliferation, differentiation, and carcinogenesis. As an important modulator of biological activity, signal transduction via protein...Full Text Available
Microbonding of the CMS Tracker Inner Barrel (TIB) and Tracker Inner Disks (TID) modules was shared among six different Italian Institutes. The organization devised and the infrastructure deployed to handle this task is illustrated. Microbonding specifications and procedures for the different types of TIB and TID modules are given. The tooling specially designed and developed for these types of modules is described. Experience of production is presented. Attained production rates are given. An analysis of the microbonding quality achieved is presented, based on bond strengths measured in sample bond pull tests as well as on rates of bonding failures. Italian Bonding Centers routinely performed well above minimum specifications and a very low global introduced failure rate, at the strip level, of only $\\sim$0.015 \\% is observed.
This paper describes the benchmark analysis results of Rapid Boron Dilution (RBD) transient tests. The RBD transient tests were carried out at University of Maryland. The data were obtained as a part of the International Standard Problem No. 43, ISP-43, for code assessment. Nuclear Power Engineering Corporation (NUPEC) participated the benchmark analysis of ISP443 with the PLASHY code. The PLASHY code is a general purpose single-phase fluid analysis code, developed by NUPEC. The code has two types of module, Cartesian/Cylindrical coordinate system module and BFC module. In order to reduce the computing time, the Cartesian/Cylindrical coordinate system module was employed. All calculations were done on a parallel computer, IBM SP2, by using the 12 of 76 CPU units. (author)
The synapsin III gene, SYN3, which belongs to the family of synaptic vesicle-associated proteins, has been implicated in the modulation of neurotransmitter...Full Text Available
Variations in thermal energy costs of single module solar central receiver systems using one, two, three, and four aperture cavity receivers at a location corresponding to Barstow, California are investigated for nominal power ratings ranging from 100 MWt to 900 MWt. Also considered are the effects on energy costs of changes in plant latitude, and the energy cost impact of the replacement of the single module design with multiple connected modules producing the same thermal power. The results, obtained with the aid of the DELSOL2 computer program, indicate that solar central receiver plant energy costs are insensitive functions of power level, latitude, and configuration. No clear cost of energy advantage between single and multiple modules is seen.
Artificial selection and experimental evolution document natural selection under controlled conditions. Collectively, these techniques are continuing to provide fresh and important insights into the...Full Text Available
Sesame varieties/genotypes showed a good response to radiation with gamma rays and treatments with EMS. In M_1 both gamma rays and EMS influenced germination, seedling height, survival of plants and pollen fertility/sterility, producing deleterious effects on these characters. Compared to black seeded genotypes, white seeded ones are more susceptible to radiation. Both gamma rays and EMS produced various types of morphological variations in M_2 generation. These were dwarf plant mutants, mottled and fleshy leaved mutants (sterile), fasciated stem, flower colour, altered phyllotaxy, early, uniculm, capsule size variations, multiple capsule/leaf axil, seed coat colour variations, indehiscent and semi-indehiscent type mutants. Moreover, studies on quantitative characters including seed yield revealed the induction of mutants in both positive and negative directions for such traits which made a good scope of selection of ...
Objective: To develop a computerized method of internal dose estimation on radiation protection. Methods: Based on MIRD mathematic model of the organs and by means of the programming language of MS Visual Basic 6.0, a computer program of dose estimation in internal radiation was developed for radiation protection. Results: The computerized method of dose estimation for internal radiation was completed. Conclusions: This computerized method is very convenient for internal radiation dose estimation of several aspects. It can also be used in radiation accident. (authors)
German translation of the publication 'The evaluation of risks from radiation' published in 1965 by the International Commission on Radiological Protection. In a survey, genetic and somatic risks from radiation are presented and explained. (HP).
This book gives an overview of the entire field of radiation protection with the subject areas radioactivity, X-rays, UV radiation, laser beams and high-frequency electromagnetic fields. It deals graphically with the most important physical notions, the incidence, origin, properties and biological effects of types of radiation, administrative and practical protection measures and the code of rules governing them. Apart from fundamentals of radiation protection the emphasis on the following: natural radiation exposure, radiation exposure to radon, disaster relief plans in the environment of nuclear plant, the precautionary radiation protection system evolved after Chernobyl, radiation exposure through UV radiation devices, radio, RF communication, radar, microwave ovens and high-voltage transmission ...
Oxide superconducting thin films were irradiated with X-rays and ultra-violet (UV) light, and induced radiation effects on electrical and chemical properties were examined by transport measurement, X-ray diffraction analysis (XRD), diamagnetization measurement and X-ray photoemission spectroscopy (XPS). After irradiation for ErBa_2Cu_3O_x films with X-rays emitted from a Rh tube for 100 hours, superconductivity was remarkably damaged, destroying the zero-resistance state. The UV-light irradiation for Bi_2Sr_2CaCu_2O_x films was performed in He gas of about 500 Pa with a low pressure mercury lamp. The superconductivity was gradually degraded with the UV irradiation time up to 70 minutes. In both cases, adequate oxygen-annealing treatments restored superconductivity. The X-ray photoemission spectra showed that the mean Cu valence of the films was decreased approximately from +2 to +1 by the irradiation. From these results we can find that irradiation with the X-ray ...
Portal verification images were generated from the photon contamination in electron beams produced by a linear accelerator during treatment of patients receiving high-energy electron radiation therapy (8-14 MeV). An experimental storage phosphor system was used to record the images and display them on laser-printed film. Images were obtained from four or more treatment fractions from 21 cases of head and neck cancer. Precision in field placement was estimated by determining the position of a selected anatomic landmark relative to the center of the field for each series of images. The average standard deviation in the field-position measurements was 3.8 mm. Several procedural problems were also detected and corrected after review of the verification images. The results indicate that the emphasis placed on monitoring and control of field-positioning error in high-energy electron treatments should be similar to the emphasis placed on this aspect ...
Development of techniques for separating isomeric nuclides is important to the investigation of schemes for gamma-ray lasers. In preparation for an experiment to separate 10_1_4 atoms of the /sub 197m/Hg (299 keV, tau/sub 1/2/ = 24 hours) isomer, we report isotopically selective resonance ionization of mercury atoms. This has been accomplished by three-step excitation via the 6_3P"1 and 8_1S"0 excited states, using three collinear pulsed laser beams of 254, 286, and 532 nm wavelengths from a Nd:YAG and two dye lasers. These beams were passed through a closed mercury-vapor cell containing electrostatic plates to which the ions were drawn. Ion current and fluorescent radiation were measured as a function of laser frequency. Hyperfine structures for the 254- and 286-nm transitions were observed.
A series of copolymers based on the cellulose acetate/propionate-g.co-acrylic acid system has been prepared under radiation-induced control. These copolymers have been assessed for their water-retention capacity both in an unmodified state and after ''decrystallization'' or ''neutralization'' treatments. The grafting of acrylic acid onto the cellulose acetate/propionate had little effect on the water retention power of the cellulose acetate/propionate. However, improvements to the water retentivity was obtained after ''decrystallization'' procedures had been carried out on the copolymers using selected alkali metal salts with methanol as the continuous medium. The water-retentivity of the copolymers increased with increase in the extent of grafting, though the effect is less pronounced at high graft levels. Neutralization of the ...
The millimeter microwave source of gyrotron-traveling-wave amplifier (gyro-TWT) is capable of generating high power coherent radiation in a broad bandwidth, while its performance is severely deteriorated by the stability problems. This paper focuses on modeling and the stability analysis of the Naval Research Laboratory (NRL) Ka-band TE{sub 01} mode gyro-TWT based on an interaction circuit alternately loaded with lossy ceramic shells and metal rings. The propagation characteristics of the interaction circuit is analyzed first, based on which the boundary impedance method is employed to build an equivalent uniform lossy circuit. Then the stability of the interaction system is studied using linear and nonlinear theories. The analysis reveals that, due to the special waveguide structure and the dielectric loss, the propagation characteristics of the complex waveguide are similar to that of a uniform lossy circuit. The analysis of the absolute instabilities ...
The millimeter microwave source of gyrotron-traveling-wave amplifier (gyro-TWT) is capable of generating high power coherent radiation in a broad bandwidth, while its performance is severely deteriorated by the stability problems. This paper focuses on modeling and the stability analysis of the Naval Research Laboratory (NRL) Ka-band TE01 mode gyro-TWT based on an interaction circuit alternately loaded with lossy ceramic shells and metal rings. The propagation characteristics of the interaction circuit is analyzed first, based on which the boundary impedance method is employed to build an equivalent uniform lossy circuit. Then the stability of the interaction system is studied using linear and nonlinear theories. The analysis reveals that, due to the special waveguide structure and the dielectric loss, the propagation characteristics of the complex waveguide are similar to that of a uniform lossy circuit. The analysis of the absolute instabilities characterizes the ...
Current bioartificial extra-corporeal systems are bioreactors where cells are separated from the surrounding media by porous polymeric membranes. The present work focuses on the design of membranes that allow the differential diffusion of plasma metabolites and proteins such as immunoglobulin (IgG). This design will improve catabolites removal and reduce possible immune response and virus infection. We demonstrate the feasibility to synthesize the hydrogels confined to the macroporous structure of membranes by radiation-induced in situ polymerization. The hollow-fiber membranes were soaked in aqueous monomeric solution, rinsed and irradiated while submerged in oil. This procedure confined the hydrogel to the void internal volume of the pores of the membrane. Hydrogels of polyacrylamide and polyHEMA were synthesized this way by irradiation at 10 kGy. Hydraulic permeability and diffusion of glucose, albumin and IgG were measured in these hydrogel-filled membranes. ...
Selected local woods and their wood-polymer combinations or composites (WPC) were tested for their thermal conductivity and their fire resistance. WPC were prepared by polymerizing monomers ''in situ'' in oven dried woods by gamma radiation. The monomers included acrylonitrile (AN), 60% styrene-40% acrylonitrile (STAN), methyl methacrylate (MMA), 95% methyl methacrylate-5% dioxane (MD), and vinylidene chloride (VDC). A reduction in thermal conductivity was exhibited by all the composites prepared. W-PAN showed the greatest reduction in thermal conductivity and W-PSTAN in general showed the least. An explanation is suggested for this behaviour. The polymers PMMA and PMD were found to enhance flammability of the woods while PVDC, PAN, and PSTAN imparted fire resistance to the woods. Of the six local woods studied, Ramin-and-Keruing-polymer composites showed the highest flammable tendencies obtained. The ...
The aim of this work is the evaluation of biodistribution and radiation dosimetry of a cocaine analog, the N-(3-iodo-prop-2E-enyl)-2beta-carbo-methoxy-3beta-(4-methyl-phenyl) nor-tropane (PE2I), labeled with carbon 11 ([{sup 11}C]PE2I). The [{sup 11}C]PE2I is a selective radioligand for imaging neuronal dopamine transporter (DAT) with positron emission tomography (PET). The DAT is a membrane-bound pre synaptically located protein that regulates the concentration of dopamine at nerve terminals. DAT radioligands are often used to evaluate the progression of Parkinson's disease or the efficiency of neuro-protective therapeutics and, typically, these studies required several successive PET scans. (author)
Presently in the FRG there are essentially three institutions involved in corrosion experiments related to high level waste package materials, namely KfK-INE, Nukem and Bayer Leverkusen. In 1981 KfK-INE started a corrosion test program aiming at the selection of suitable canister materials for vitrified high level waste. The program encompassed electrochemical investigations, which were concluded in 1984. Moreover field corrosion tests and laboratory experiments were initiated, and are still ongoing. Several possible canister materials such as mild steel, Ti-Pd-alloy, Hastelloy C4 and others were investigated under the influence of varying parameters such as temperature, and radiation. Both Nukem Company and DWK were assigned the responsibility to conceive and develop a cask for the direct final disposal of spent fuel assemblies. Two solution turned out as most promising for corrosion protection of final disposal casks: (1) protective layer of ...
The design of a gaging head for a portable radionuclide X-ray fluorescence analyzer is described. The gaging head is designed as a construction unit system which enables the application of lateral reflexion geometry as well as of coaxial geometry. It is designed so that adjustment from one geometry to the other is labour and time saving. The selection of characteristic radiation is performed by a couple of Ross' differential filters. These filters are prepared by a novel technique developed by our laboratory. The filter exchange is effected by the longitudinal move of the couple of filters encapsulated in a holder. The shift of the filters is controlled by means of a triggering mechanism situated in the body of the gaging head handle. This design makes is possible to handle the gaging head during measurements with one hand. A simple interchange of the absorption filter for the transmissive filter allows the operator to avoid any unwanted shift ...
A pilot project was started in 1977 over the Lake Superior basin to measure water storage on the land area using aerial gamma-ray spectrometry to provide hydrologic information for forecasting inflow to the lake. Two airborne surveys were made, respectively in November 1977 and March 1978 which provided estimates of the increase in snow water equivalent between these surveys. The basin is located on the Canadian Shield and consequently, the gamma radiation count rate is quite variable. The airborne results are compared with ground measurements on selected flight lines and show generally good agreement. Two equipment calibrations in the Ottawa area provided inconsistent parameter values which are consequently also reflected in the results over the Lake Superior basin. The project has demonstrated to-date that the technique can be developed into an operational system for measuring snow cover water equivalent of this vast and remote area by using ...
The National Spallation Neutron Source (NSNS), in which neutrons are generated by bombarding a liquid mercury target with 1 GeV protons, will place extraordinary demands on materials performance. The target structural material will operate in an aggressive environment, subject to intense fluxes of high energy protons, neutrons, and other particles, while exposed to liquid mercury and to water. Components that require special consideration include the Hg liquid target container and protective shroud, beam windows, support structures, moderator containers, and beam tubes. In response to these demands a materials R and D program has been developed for the NSNS that includes: selection of materials; calculations of radiation damage; irradiations, post irradiation testing, and characterization; compatibility testing and characterization; design and implementation of a plan for monitoring of materials performance in service; and materials engineering ...
The Holifield Radioactive Ion Beam Facility (HRIBF) now under construction at the Oak Ridge National Laboratory will use the 25-MV tandem accelerator for the acceleration of radioactive ion beams to energies appropriate for research in nuclear physics; negative ion beams are, therefore, required for injection into the tandem accelerator. Because charge exchange is an efficient means for converting initially positive ion beams to negative ion beams, both positive and negative ion sources are viable options for use at the facility; the choice of the type of ion source will depend on the overall efficiency for generating the radioactive species of interest. A high-temperature version of the CERN-ISOLDE positive ion source has been selected and a modified version of the source designed and fabricated for initial use at the HRIBF because of its low emittance, relatively high ionization efficiencies and species versatility, and because it has been engineered for remote ...
The Holifield Radioactive Ion Beam Facility (HRIBF) now under construction at the Oak Ridge National Laboratory will use the 25-MV tandem accelerator for the acceleration of radioactive ion beams to energies appropriate for research in nuclear physics; negative ion beams are, therefore, required for injection into the tandem accelerator. Because charge exchange is an efficient means for converting initially positive ion beams to negative ion beams, both positive and negative ion sources are viable options for use at the facility; the choice of the type of ion source will depend on the overall efficiency for generating the radioactive species of interest. A high-temperature version of the CERN-ISOLDE positive ion source has been selected and a modified version of the source designed and fabricated for initial use at the HRIBF because of its low emittance, relatively high ionization efficiencies and species versatility, and because it has been engineered for remote ...
A programme has been initiated by the Coordinating Office for Monitoring of enhanced natural radioactivity of the Federal Office for Radiation Protection to investigate different kinds of sample materials with enhanced naturally occurring radioactivity (NORM) such as scales from oilfield and naturally gasfield pipes, blast furnace sludge and sinter dust from the production of pig iron, as well as bauxit and red mud from the production of aluminium oxide. The aim of these investigations is to find proper preparation and measuring methods which allow, in particular, a sample treatment with optimised effort combined with a reliable determination of the specific activities of the dominating radionuclides. Of particular interest is the method of gamma-ray spectrometry, since this method has been used for most of our studies of sample materials. Due to different compositions of calibration and NORM-samples, e.g. different densities, and the analysis of low-energy ...
Geological, geophysical, thermal, petrophysical and hydrological data available for the East Mesa hydrothermal system that are pertinent to the construction of a computer model of the natural flow of heat and fluid mass within the system are assembled and correlated. A conceptual model of the full system is developed and a subregion selected for quantitative modeling. By invoking the Boussinesq approximation, valid for describing the natural flow of heat and mass in a liquid hydrothermal system, it is found practical to carry computer simulations far enough in time to ensure that steady-state conditions are obtained. Initial calculations for an axisymmetric model approximating the system demonstrate that the vertical formation permeability of the deep East Mesa system must be very low (k/sub v/ approx. 0.25 to 0.5 md). Since subsurface temperature and surface heat flow data exhibit major deviations from the axisymmetric approximation, exploratory three-dimensional ...
The production of cellulolytic enzymes from fungi has been extensively studied. Several mutants of Trichoderma reesei were selected. Most of the studies were carried out on T. reesei, T. viride, T. harzianum, Penicillium funiculosum, Altemaria alternata. Aspergillus phoenicis, A. ustus, A. tamarii, A. japonicus, and A. niger. T. koningii is one of the most active producers of the so-called C, factor, which is indispensable for the rapid and extensive attack on crystal-line cellulose. However, Trichodenna is known to excrete only small amounts of {beta}-glucosidase. Therefore, Trichoderma is supplemented with {beta}-glucosidase from Aspergillus to increase the saccharification rate of cellulose to glucose as the main sugar. Induction of mutations in Trichodenna spp. rather than T. viride as a tool for the enhancement of {beta}-glucosidase activity was reported. Unfortunately, T. reesei is a poor producer of {beta}-glucosidase. On the other hand, T. harzianum M{sub ...
Emergency response preparedness for radiological accidents involving wound contamination has become more important, considering the current extending tendency in the nuclear industry related to the nuclear fuel cycle. The US National Council on Radiation Protection and Measurements (NCRP) proposed a biokinetic and dosimetric model for the intake of radionuclides through contaminated wounds in 2007. The present paper describes the implementation of this NCRP wound model for the prediction of systemic behaviour of some important radioactive elements encountered in workplaces related to the nuclear industry. The NCRP wound model was linked to the current ICRP systemic model at each blood compartment and simultaneous differential equations for the content of radioactivity in each compartment and excreta were solved with the Runge-Kutta method. The results of the calculation of wound, whole-body or specific organ retention and daily urinary or faecal excretion rate of ...
Ionizing radiation dose levels due to home radon can rise to levels that would be illegal for workers in the nuclear industry. It is well known that radon levels within homes and from home to home, and also from month to month, vary considerably. To define an Isle of Man radon seasonal correction factor, readings were taken in eight homes over a 12 month period. An average island indoor exposure of 48 Bq m{sup -3} (range 4-518 Bq m{sup -3}) was determined from 285 homes selected from a cohort of 1300 families participating in the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) in the Isle of Man. This compares with a UK home average of 20 Bq m{sup -3} and a European Union average (excluding UK) of 68 Bq m{sup -3}. Ten homes of those measured were found to have radon levels above the National Radiological Protection Board 200 Bq m{sup -3} action level. There are 29 377 homes on the Isle of Man, suggesting that there could be some ...
Alloy HT-9 is being used for both duct and cladding applications in advanced liquid-metal reactor (LMR) experiments. This tempered martensitic steel was selected for use as an LMR core component material primarily because of its excellent resistance to radiation-induced swelling. Experiments conducted in the Fast Flux Test Facility (FFTF) at 410 degree C and exposures in the range of 150 to 175 displacements per atom (dpa) have shown that Ht-9 exhibits only a 0.2 to 0.3% increase in volume. Cold-worked austenitic steels exhibit volumetric increases of 20 to 30% at 410 degree C, Alloy HT-9 is being used for a series of fuel pin experiments in the FFTF, and these tests have achieved a burnup of 175 MWd/kg metal and a fluence of 25 x 10"2"2 n/cm"2 (E > 0.1 MeV) without fuel pin breach. The high confidence placed in HT-9 is based on a wide series of in- and ex-reactor experiments. Test results for these experiments are summarized in this paper.
Simple correlations and corresponding nomographs are presented, which express the maximum useful heat received from salt-gradient solar ponds throughout the year or during a specified season of the year, and the corresponding optimum depth of the nonconvective zone in terms of the thickness of the upper convective zone and the temperature under which the maximum useful heat is received. The correlations are valid for the Athens (Greece) area or for regions with a similar climate, because solar radiation and ambient temperature values for Athens have been employed, obtained by a statistical process of hourly measurements over a period of about 20 years. For other climates, it is easy to develop similar correlations using the same methodology, Development of the proposed correlations is based on a method, which simulates the transient operation of the salt-gradient pond using finite-differences, and calculates the useful heat received hourly along the typical year. ...
The feasibility of developing a fusion power monitor based on a fluid activation detector is considered here. The activation fluid may be either a liquid or a gas and its composition can be selected from a number of candidate materials to provide desired activation and decay characterisitcs. Performance calculations indicate that ordinary water would be a nearly ideal activation fluid. The "1"6O(n,p)"1"6N reaction has a threshold at about 10 MeV and a cross section energy dependence giving it a predominant response for unmoderated D-T fusion neutrons. Adequate activation can be obtained at moderate flow rates for remote counting away from the high radiation area of the reactor. The 7.16 sec half-life of "1"6N is ideal for remote counting with subsequent decay in a small hold-up tank to eliminate activity build-up in the recycled water.
Objective: To investigate the feasibility of low-dose single-slice helical CT in pulmonary CT scan and evaluate the clinical application. Methods: Thirteen cases were selected out of 132 cases, in which low-dose (50mAs) single-slice helical CT scan of chest was performed. This set of cases included 7 cases of multiple metastatic nodules; 3 of solitary pulmonary, nodule; and 3 of pulmonary patchy lesions. Regular dose (170mAs) CT scan was also performed on all those patients. The regular dose and low dose CT scan were compared on sensitivity of detecting the lesions; the performance in demonstrating the details of the abnormalities; and the capability of revealing the segmental bronchi as well. Results: The same number and size of the pulmonary nodules were revealed with scan modalities loaded with different doses. No significant difference in demonstrating the details of the nodules and the segmental bronchi was found between both modalities (#chi#"2=0.123-3.39, ...
Acceptance testing of mammographic imaging systems technical is the first approach in order to guarantee that mammograms will be achieved with the minimum radiation dose compatible with an image quality suitable for diagnose purposes. The aim of this study is to assess the practical applicability of different protocols in acceptance test of digital mammographic systems. This study has been carried out on the results of the acceptance tests of five flat panel digital mammographic systems. Parameters established in the systems technical specifications and those evaluated in the consulted protocols were tested. Due to the fact that the legislation in our country does not demand to consider a specific protocol, the results obtained were also compared considering different existing protocols. Results show discrepancies between manufacturers limiting values and those established in the protocols. Some parameters, such as the automatic exposure control compensation and ...
An overview is given of the interest of the Dutch government, several organizations and consumers in the quality of the indoor environment. Main aspects, sub-aspects and indicators for the indoor environment of dwellings are listed: site selection, thermal comfort, air quality, light, view, privacy, noise, safety, and radiation. [Dutch] In het veld wordt onvoldoende aandacht en prioriteit gegeven aan de kwaliteit van het binnenmilieu. Het ligt voor de hand de kennis over de relatie gezondheid en binnenmilieu bij professionele partijen te vergroten. In dit kader is het Binnenmilieuprofiel voor de kantooromgeving geintroduceerd. Aan de hand hiervan kan de discussie worden gevoerd tussen vrager en aanbieder over de kwaliteit van het binnenmilieu. Het zou de basis kunnen zijn voor een keurmerk Gezond Gebouw. Dezelide binnenmilieuproblematiek doet zich natuurlijk ook voor bij woningen. In dit artikel wordt een introductie gegeven van het ...
The GASPAR module utilized in MAXIGASP and POPGASP has been verified by hand calculations. The program operates as documented by the NRC [Eckerman et. al. 1980]. Equations used in the code to calculate downwind deposition rates, concentrations in air, on ground surfaces, and in vegetables, meat, and milk are provided in this report.
Metabotropic glutamate receptor 2/3 (mGluR2/3) agonists were shown previously to nonselectively decrease both cocaine- and food-maintained responding in rats. mGluR2 positive allosteric modulators (PAMs)...Full Text Available
Using a sensitive optical wavelength modulation technique the surface-plasmon excited on a gold grating surface immersed in sulfuric acid is studied at the same time as cyclic voltammetry is undertaken. Because of the optical sensitivity of the modulation technique significant optical effects are observed at potentials well below those at which any gross oxidation effects occur.
We provide an analytic study of the dynamics of semiconductor lasers with injection (pump) of spin-polarized electrons, previously considered in the steady-state regime. Using complementary approaches of quasi-static and small signal analyses, we elucidate how the spin modulation in semiconductor lasers can improve performance, as compared to the conventional (spin-unpolarized) counterparts. We reveal that the spin-polarized injection can lead to an enhanced bandwidth and desirable switching properties of spin-lasers.
Computer simulations and experiments indicate that we can shape the infrared picosecond pulses of the Mark III FEL in amplitude, frequency, and phase. Strongly modulated fundamental and second harmonic pulses have been generated by operating the Mark III FEL in the regime of strong sideband growth. In this paper, we present the results of simulations and experiments for second harmonic generation with fundamental inputs from 2 to 3 {mu}m.
Certification as applied to existing computer codes includes the verification and validation process, placing the code in configuration control, establishing user qualification standards and training requirements. All software intended for use in critical calculations must be certified. This report is intended to fulfill the requirements for the certification of the SHIELD, SHLDED, GEDIT, GENPRT, FIPROD, FPCALC, and PROCES modules of the SHIELD system built February, 1992, by W.S. Parks. These modules are used for burnup, cooling, separate, and edit calculations.
We determine the structure of the total homology groups of exotic Springer fibers as affine Weyl group representations. As applications, we provide single top/socle property of standard modules in the exotic Deligne-Langlands correspondence (except for root of unity case), an analogue of Verma's theorem, the coincidence of analytic/geometric gradings in the $C ^{\\infty}$-realization of anti-spherical modules of graded Hecke algebras of type $\\mathsf{BC}$ with unequal parameters, among others.
It is proposed to measure the spot sizes and polarization of #gamma# beams of future #gamma#e and #gamma##gamma# colliders detecting e"+e"- pairs produced as a result of interaction of high energy #gamma# quanta with density modulated and not modulated laser photons. The quantum electrodynamics cross sections, necessary numerical results as well as a short comparison of the proposed method with some other methods are given. (orig.).
We study the influence of Sr substitutions on the structural counterpart of the MI transition of Formula Not Shown . When Sr content increases, the commensurate CDW modulation of pure Formula Not Shown is changed into an incommensurate short range modulation that we attribute to a charge ordering of the Formula Not Shown electrons. The same features are observed in S deficient samples.
Oestrogen has been reported to modulate tumour necrosis factor (TNF), interleukin (IL)-1 and IL-6 cytokine levels in human mononuclear cell cultures. In the present study, the effects of exogenous oestrogen...Full Text Available
The National Center for Photovoltaics sponsored the 17th Workshop on Crystalline Silicon Solar Cells & Modules: Materials and Processes, held in Vail, CO, August 5-8, 2007. This meeting provided a forum for an informal exchange of technical and scientific information between international researchers in the photovoltaic and relevant non-photovoltaic fields. The theme of this year's meeting was 'Expanding Technology for a Future Powered by Si Photovoltaics.'
This proceedings is the compilation of papers presented at the ninth PV Performance and Reliability Workshop held at the Sheraton Denver West Hotel on September 4--6, 1996. This years workshop included presentations from 25 speakers and had over 100 attendees. All of the presentations that were given are included in this proceedings. Topics of the papers included: defining service lifetime and developing models for PV module lifetime; examining and determining failure and degradation mechanisms in PV modules; combining IEEE/IEC/UL testing procedures; AC module performance and reliability testing; inverter reliability/qualification testing; standardization of utility interconnect requirements for PV systems; need activities to separate variables by testing individual components of PV systems (e.g. cells, modules, batteries, inverters,charge controllers) for individual reliability and then test them in ...
KM3NeT is a future deep-sea research infrastructure hosting a neutrino telescope with a volume of at least one cubic kilometer to be constructed in the Mediterranean Sea. The experiment aims to detect high-energy cosmic neutrinos using a 3D array of optical modules to collect the Cherenkov light induced by charged particles in the water. Upward going muons and showers produced in neutrino interactions with the surrounding matter will allow the search and study of possible sources of extra-terrestrial neutrinos. The design of optical modules makes an important impact on the performance and cost of the KM3NeT project. Several different optical module configurations are under consideration; based on glass pressure spheres containing: a large (10 in.) hemispherical photomultiplier tube (with a multi-anode version as an option); 25-31 3 in. photomultiplier tubes, or a crystal scintillator-based hybrid device (X-HPD). The ...
This Phase 1 final report covers the work performed by Springborn Testing and Research, Inc., for the period October 1, 1997 to June 30, 1998 under the Department of Energy Cooperative Agreement Number DE-FC36-97GO10255, entitled Development of Flame Retardant PV Module Encapsulants. While use of roof-mounted arrays has always been an attractive means of deploying PV, only within recent years have such building integrated concepts (BIPV) found renewed interest among module makers and end-users. Prior to building integrated and rooftop applications, flammability requirements for modules have not been a great industry concern. However, with growing interest in BIPV and the requirement for building code requirements for commercial and industrial structures, flammability issues have become a barrier to entry for many module constructions into this potentially huge domestic market for PV. The overall goal of ...
Metabolic profile is an important biological marker of neoplastic processes not only in the tumor itself but also in the host organism. The neuro-hormone melatonin has been implicated in the experiments as an oncostatic agent. Female Wistar:Han SPF rats (Velaz, Prague, Czech Republic) were irradiated continuously for 15 days using a daily gamma rays dose of 96 mGy. At the end of exposure one group of rats was administered 5 mg/kg b.w. of dimethylbenz/a/anthracene (DMBA) intragastrically. During the period of exposure to ionizing radiation a part of the animals was supplied with melatonin (M) at a concentration of 20 #mu#l/ml in drinking water. Selected parameters of lipid and carbohydrate metabolism and levels of selected hormones were determined 2, 30 and 100 days post-irradiation. The irradiation itself caused only small changes in tissue lipids. The application of a single low dose (subthreshold from the point of view of ...
The 177 underground storage tanks at the DOE's Hanford Site contain an estimated 180 million tons of high-level radioactive wastes. It is desirable to remove and concentrate the highly radioactive fraction of the tank wastes for vitrification. Resorcinol-formaldehyde (R-F) resin, an organic ion-exchange resin with high selectivity and capacity for the cesium ion, which is a candidate ion-exchange material for use in remediation of tank wastes. The report includes information on the structure/function analysis of R-F resin and the synthetic factors that affect performance of the resin. CS-100, a commercially available phenol-formaldehyde (P-F) resin, and currently the baseline ion-exchanger for removal of cesium ion at Hanford, is compared with the R-F resin. The primary structural unit of the R-F resin was determined to consist of a 1,2,3,4-tetrasubstituted resorcinol ring unit while CS-100, was composed mainly of a 1,2,4-trisubstituted ring. CS-100 shows the ...
The Holifield Radioactive Ion Beam Facility now under construction at the Oak Ridge National Laboratory will use the 25 MV tandem accelerator for the acceleration of radioactive ion beams to energies appropriate for research in nuclear physics; negative ion beams are, therefore, required for injection into the tandem accelerator. Because charge exchange is an efficient means for converting initially positive ion beams to negative ion beams, both positive and negative ion sources are viable options for use at the facility. The choice of the type of ion source will depend on the overall efficiency for generating the radioactive species of interest. Although direct-extraction negative ion sources are clearly desirable, the ion formation efficiencies are often too low for practical consideration; for this situation, positive ion sources, in combination with charge exchange, are the logical choice. The high-temperature version of the CERN-ISOLDE positive ion source has been ...
Promoting the exchange of information related to implementation of the As Low as Reasonably Achievable (ALARA) philosophy is a continuing objective for the Department of Energy (DOE). This report was prepared by the Brookhaven National Laboratory (BNL) ALARA Center for the DOE Office of Health. It contains the fifth in a series of bibliographies on dose reduction at DOE facilities. The BNL ALARA Center was originally established in 1983 under the sponsorship of the Nuclear Regulatory Commission to monitor dose-reduction research and ALARA activities at nuclear power plants. This effort was expanded in 1988 by the DOE`s Office of Environment, Safety and Health, to include DOE nuclear facilities. This bibliography contains abstracts relating to various aspects of ALARA program implementation and dose-reduction activities, with a specific focus on DOE facilities. Abstracts included in this bibliography were selected from proceedings of technical meetings, journals, ...
This bibliography contains abstracts relating to various aspects of ALARA program implementation and dose reduction activities, with a focus on DOE facilities. Abstracts included in this bibliography were selected from proceedings of technical meetings, journals, research reports, searches of the DOE Energy, Science and Technology Database (in general, the citation and abstract information is presented as obtained from this database), and reprints of published articles provided by the authors. Facility types and activities covered in the scope of this report include: radioactive waste, uranium enrichment, fuel fabrication, spent fuel storage and reprocessing, facility decommissioning, hot laboratories, tritium production, research, test and production reactors, weapons fabrication and testing, fusion, uranium and plutonium processing, radiography, and aocelerators. Information on improved shielding design, decontamination, containments, robotics, source prevention ...
We describe a new apparatus that combines pulsed laser excitation in a molecular beam with surface-science methods for preparation of clean single-crystal surfaces and detection of adsorbates to enable state-selected studies of gas-surface reaction dynamics. Reactant molecules are prepared in specific vibrationally excited states via overtone pumping using tunable, narrow-band laser radiation. The collision-free environment of the molecular beam prevents relaxation of the prepared molecules before impact on the target surface and enables complete control over the collision energy and incidence angle. Chemisorption products are detected after a given deposition time by Auger electron spectroscopy. To achieve sufficient beam flux of state-selected reactant molecules for product detection by standard surface-science techniques, we use a high-intensity, short-pulse molecular-beam source matched to the low duty cycle of the ...
Alloys of zirconium are widely used in various core components of power reactors. Nuclear assemblies require high degree of reliability and integrity for performing in radiation and corrosive atmosphere. The hostile environments of reactor core and inaccessibility for repairs make it mandatory to select only those joining techniques which produce not only superior quality but are also amenable to NDT methods and such other techniques which ensure acceptable performance. The author has worked on various types of welding of zirconium alloys for different applications. Modern techniques in electron beam (EB) welding, resistance welding, GTAW welding and laser welding have been developed for joining Zr alloys components for different types of reactors. Many of these have been standardized and successfully used in production. Several advancements have been made in the welding technologies towards achieving high productivity and increased reliability ...
Subject to the provisions of the Radiation Protection Act, the Authority, on the advice of ...(f) in collaboration with the Radiation Protection Board, conduct an ionising radiation monitoring programme and ...or document kept under the control of the Radiation Protection Board.
Described and discussed in this paper are radiation processes and their advantages over the conventional techniques. Radiation sterilization of medical products, food irradiation, wood plastic composites, and radiation treatment of sewage and waste waters are presented. The Philippine experience in using these technologies, its problems and barriers are also given. (ELC).
This thesis deals with the evaluation of Solar Grade Silicon (SoG-Si) purified by different techniques, and also the fabrication and characterization of high efficiency and advanced bifacial solar cells. In the beginning of Chapter 1, various SoG-Si production methods relevant for this work are qualitatively described. The three feedstock materials used in this work are from the Fluidized Bed Reactor (FBR) process, metallurgical feedstock-I and feedstock-II process. In metallurgical feedstock-I, the lifetime of the minority charge carriers in multicrystalline silicon (mc-Si) samples at the grain boundaries are found to be higher than the grains themselves possibly due to lower resistivities in the grain boundaries. The efficiency of the best solar cell obtained using the mc-Si metallurgical feedstock-I is 16.1%. It has been identified that the fast light induced degradation, whose magnitude is lower than that of a reference cell suggests the formation of a B-metal complex in the SoG-Si ...
Nitroaromatic radiosensitizers become metabolically bound preferentially to hypoxic cells and at least 10/sup 9/ adducts/cell can be tolerated as non-toxic. EMT-6 tumor cells have been incubated in hypoxia in the presence of /sup 3/H-Misonidazole and /sup 125/I-Azomycin Riboside for various times and the amount of /sup 3/H or /sup 125/I bound/cell was determined. Cells were stored as monolayers at 25"0C for up to 96 hr to accumulate radioactive decays and transferred at various times to 37"0C for colony-forming assays. No radiation inactivation was measured in cells which had incorporated at least 10/sup 6/ /sup 3/H or 10/sup 5/ /sup 125/I atoms. Previous studies had shown that -- 1% of MISO adducts to EMT-6 cells was associated with cellular DNA. These data indicate that the radiation-induced damage produced by these quantities of bound /sup 3/H or /sup 125/I causes little or not cell inactivation. The results of current studies to measure the ...
Nuclear fuel vendors in Japan are now studying reprocessed uranium (RepU) fuel in order to prepare for full scale utilization in the future. Separate studies are made for PWR and BWR fuel. The study consists of 2 phrases. The purposes of phase-1 are to understand various RepU characteristics in the fuel fabrication process, to analyze the core characteristics by loading RepU assemblies, to solve the problems clarified in the study, and to collect basic data for licensing. In phase-2, the effects of impurities on the fabrication process will be evaluated, and the safety of RepU fuel manufacturing will be confirmed with a RepU fuel fabrication campaign in 1990. The neutronic data will be collected after insertion into power reactors, and the data will be used to verify plant safety for full utilization of RepU in the future. This paper summarizes the phase-1 study results. 1. RepU Characteristics. The internal and external radiation exposures due to nuclide ...
Purpose: Reconstruction of organ doses of selected organs and tissues from radiographic settings and exposure data collected during chest X-ray examinations of children of various age groups performed in Dr. von Hauner's Kinderspital (children's hospital of the University of Munich, DvHK) between 1976 and 2007. Materials and Method: The dosimetric data of all X-ray examinations performed since 1976 at DvHK were stored electronically in a database. After 30 years of data collection, the database now includes 305 107 radiological examinations (radiographs and fluoroscopies), especially 119 150 chest radiographs of all age groups. Reconstruction of organ doses in 40 organs and tissues in X-ray examinations of the chest was performed based on the conversion factor concept. Results: The radiation exposure of organs in projection radiography is determined by the exact site of the organs relative to the edges of the X-ray field and ...
The expanding plasma produced when an intense pulse of laser radiation is focused in vacuum onto a solid target has been used as a source of highly stripped ions for collision cross-section measurements. Usable fluxes of carbon nuclei at energies of a few hundred eV/charge have been obtained by irradiation of graphite with pulses of CO"2 laser radiation at a focused power density of 3 x 10_1_0 W/cm_2. Bombardment of aluminum and iron targets at comparable power levels have yielded ions of maximum charges of 9 and 16 respectively. A time-of-flight apparatus has been constructed to utilize the laser source for measurement of electron capture cross sections for highly stripped ions in gases at energies in the few hundred eV/charge range. Apertures collimate an ion beam from the plasma blowoff, and an electrostatic analyzer selects ions from the expanding plasma which have the same energy per charge. The beam is directed ...
During Phase 2 of our study of the CIXS conceptual design we have tackled additional important issues that are unique to the ITER environment. These include the thermal control of the crystal and detector enclosures located in an environment with a 100-250 C ambient temperature, tritium containment, and the range of crystal and detector movement based on the need for spectral adjustments and the desire to make measurements of colder plasmas. In addressing these issues we have selected a ''Dewar''-type enclosure for the crystals and detectors. Applying realistic view factors for radiant heat and making allowance for conduction we have made engineering studies of this enclosure and showed that the cooling requirements can be solved and the temperature can be kept sufficiently constant without compromising the specification parameters of the CIXS. We have chosen a minimum 3 mm combined thickness of the six beryllium windows needed in a Dewar-type enclosure and showed ...
The Department of Energy's National Solar Data Program established solar energy systems in residential and commercial buildings across the United States. These solar sites are linked to Vitro Laboratories Division's computer in the National Solar Data Network (NSDN). Vitro collects and analyzes data from this network to determine the thermal performance of each of the solar systems. The network consists of: (1) sensors which measure key performance parameters at a selected site; (2) a Site Data Acquisition Subsystem (SDAS); (3) telephone transmission circuits; and (4) a Central Data Processing System (CDPS). For the majority of parameters, raw data is collected approximately every five minutes. Solar insolation and certain other parameters, which are subject to rapid variance, are sampled every 32 seconds. Environmental information collected at the sites for the reporting month are presented. The environmental data for the NSDN are presented in ...
Development of food preservation and processing techniques by radiation was performed. Gamma irradiation at 2-10 kGy is considered to be an effective method to control pathogenic bacteria in species including Escherichia coli O157:H7. Gamma irradiation at 5 kGy completely eliminated pathogenic bacteria in beef. Gamma irradiation at such doses and subsequent storage at less than 4 deg C could ensure hygienic quality and prolong the microbiological shelf-life resulting from the reduction of spoilage microorganisms. Gamma irradiation on pre-rigor beef shortens the aging-period, improves tenderness and enhances the beef quality. And, a new beef processing method using gamma irradiation, such as in the low salt sausage and hygienic beef patty was developed. Safety tests of gamma-irradiated meats(beefs: 0-5 kGy; porks: 0-30 kGy) in areas such as genotoxicity, acute toxicity, four-week oral toxicity, rat hepato carcinogenesis and the anti oxidative defense system, were ...
This text-book (electronic book - multi-media CD-ROM) constitutes a course-book - author's collection of lectures. It consists of 13 lectures in which the reader acquaints with the basis of radiobiology: Introduction to radiobiology; Physical fundamentals of radiobiology; Radiation of cells; Modification of radiation damage of cells; Reparation of radiation damage of cells; Radiation syndromes and their modification; Radiation injury; Radiation damage of tissues; Effect of radiation on embryo and fetus; Biological effects of incorporated radionuclides; Therapy of acute irradiation sickness; Delayed consequences of irradiation; Radiation oncology and radiotherapy. This course-book may be interesting for students, post-graduate students of chemistry, biology, physics, medicine as well as for teachers, scientific workers ...
... Radiation Protection Products and Equipment Find and compare a variety of radiation protection products and equipment on the world's largest environmental industry portal. View product ...
The United States Department of Energy (U.S. DOE) has recently implemented a series of strategic initiatives to address long-term radiological surveillance needs at former U.S. nuclear test sites in the Marshall Islands. The plan is to engage local atoll communities in developing shared responsibilities for implementing radiation protection monitoring programs for resettled and resettling populations in the northern Marshall Islands. Using the pooled resources of the U.S. DOE and local atoll governments, individual radiological surveillance programs have been developed in whole body counting and plutonium urinalysis in order to accurately assess radiation doses resulting from the ingestion and uptake of fallout radionuclides contained in locally grown foods. Permanent whole body counting facilities have been established at three separate locations in the Marshall Islands including Rongelap Atoll (Figure 1). These facilities are operated and ...
Purpose: Various published reports involving intensity-modulated radiotherapy (IMRT) plans developed using automated optimization (inverse planning) have demonstrated highly conformal plans. These reported conformal IMRT plans involve significant target dose inhomogeneity, including both overdosage and underdosage within the target volume. In this study, we demonstrate the development of optimized beamlet IMRT plans that satisfy rigorous dose homogeneity requirements for all target volumes (e.g., #+-#5%), while also sparing the parotids and other normal structures. Methods and Materials: The treatment plans of 15 patients with oropharyngeal cancer who were previously treated with forward-planned multisegmental IMRT were planned again using an automated optimization system developed in-house. The optimization system allows for variable sized beamlets computed using a three-dimensional convolution/superposition dose calculation and flexible cost functions derived ...
CT-Expo is a novel MS Excel application for assessing the radiation doses delivered to patients undergoing CT examinations, based on computational methods that were used to analyze the data collected in the German survey on CT practice in 1999. The program enables the calculation of all dose quantities of practical value, such as axial dose free-in-air, weighted CTDI, dose-length product, effective dose and uterine dose. In contrast to existing programs for CT dose assessment, CT-Expo offers a number of unique features, such as gender-specific dose calculation for all age groups (adults, children, newborns), applicability to all existing scanner models including correction of scanner-specific influences, and the possibility of comparison with the results from the German CT survey on CT practice. Three different application modules offer free and standardized dose calculations as well as a comprehensive benchmarking section including guidance on ...
This chapter is concerned with standards and guidances for limiting radiation exposures. It is divided into three sections, each of which has several parts. Section 1: Ionizing Radiation -- Standards and Guidances Applicable to the Public: Part A, Radiation Protection Standards; Part B, Environmental Radiation Standards; Part C, Exempt Levels of Radioactivity; Part D, Protective Action Guides for Accidents. Section 2: Ionizing Radiation -- Standards Applicable to the Workplace. Section 3: Medical and Other Standards.
On the basis of legally provided area dose measurements and time records of fluoroscopic examinations during the operation, radiation doses to medical personnel and patients are evaluated. Adequate radiation protection measures and a careful behaviour in the operating room keep the radiation exposure to the personnel below the maximum permissible exposure. Taking into account the continuous personnel radiation monitoring and medical supervision, radiation hazards in the operating room can be considered low.
Purpose: We present an update analysis of the multiinstitutional Ewing's sarcoma study CESS 86. Methods and Materials: From January 1986 through June 1991, 177 patients with localized Ewing's sarcoma of bone, aged 25 years or less, were recruited. Chemotherapy consisted of four 9-week courses of vincristine, actinomycin D, cyclophosphamide, and adriamycin (VACA) in low-risk tumors (extremity tumors =# 100 cm"3). Local therapy was an individual decision in each patient and was either radical surgery (amputation, wide resection) or resection plus postoperative irradiation with 45 Gy or definitive radiotherapy with 60 Gy (45 Gy plus boost). Irradiated patients were randomized concerning the type of fractionation in either conventional fractionation (once daily 1.8-2.0 Gy, break of chemotherapy) or hyperfractionated split-course irradiation simultaneously with the VACA/VAIA chemotherapy (twice daily 1.6 Gy, break of 12 days after 22.4 Gy and 44.8 Gy, total dose and treatment time as for ...
The current state and need for radiation protection training in Finland have been surveyed by the Radiation and Nuclear Safety Authority STUK. The survey sought to determine whether the current requirements for radiation protection training had been met, and to promote radiation protection training. Details of the scope and quality of present radiation protection training were requested from all educational institutes and organizations providing radiation protection training. The survey covered both basic and further training, special training of radiation safety officers, and supplementary training. The questionnaire was sent to 77 educational organization units, 66 per cent of which responded. Radiation workers and radiation safety officers were asked about radiation protection ...
We have been piloting web-based multimedia learning modules (MLMs), developed by the Physics Education Research Group at the University of Illinois at Urbana Champaign (UIUC), as a "prelecture assignment" in several introductory physics courses at California State Polytechnic University at Pomona. In this study, we report the results from a controlled study utilizing modules on electricity and magnetism as a part of a blended hybrid-online course. We asked students in the experimental section to view the MLMs prior to attending the face-to-face class, and to make sure this would not result in additional instructional time, we reduced the weekly class time by one-third. We found that despite reduced class time, student-learning outcomes were not hindered; in fact, the implementation of the UIUC MLMs resulted in a positive effect on student performance on conceptual tests and classroom discussion questions. (Contains 4 figures and 1 table.)
The generalized demodulation time-frequency analysis is a novel signal processing method, which is particularly suitable for the processing of multi-component amplitude-modulated and frequency-modulated (AM-FM) signals as it can decompose a multi-component signal into a set of single-component signals whose instantaneous frequencies own physical meaning. While fault occurs in gear, the vibration signals measured from gearbox would exactly display AM-FM characteristics. Therefore, targeting the modulation feature of gear vibration signal in run-ups and run-downs, a fault diagnosis method in which generalized demodulation time-frequency analysis and envelope order spectrum technique are combined is put forward and applied to the transient analysis of gear vibration signal. Firstly the multi-...
This paper reviews the state of the art of silicon-germanium technology and assesses the problems of building thermoelectric modules in Europe, based upon silicon-germanium alloys, for use in multihundred watt radio-isotope thermoelectric generator. The generator developed in the United States for the International Solar Polar mission has been used as a reference system. The essential features of an alternative system, which employs thermocouples fabricated from improved silicon-germanium alloys based upon a design by the Fairchild Space and Electronics Company, is also described. It is concluded that although the fabrication of reliable electrical contacts will present a major problem, the technology is available in Europe to build thermoelectric modules similar to those developed for the International Solar Polar mission. (orig.).
A 100-bit slitlike aperture array spatial light modulator has been developed using 8.8/65/35 PLZT for a high-bit-density 1-D hologram memory. The most desirable characteristics, such as distortion-free diffraction-limited Fourier transform patterns and good uniformity of displayed bit patterns over 100 bits, have been realized. The lowest SNR was 86, and rise time and fall time have been 30 microsec and 8 microsec, respectively, at 190-V halfwave voltage. One-dimensional holographic storage experiments have been successfully performed using this PLZT spatial light modulator. PMID:20216813
Negative frequency has a physical meaning, the complete description of a frequency signal is a rotating complex signal, in complete description, positive frequency signal exp(iwt) and negative frequency signal exp(-iwt) is two distinguishable and independent frequency signals. Because the real-carrier modulation and demodulation do not distinguish positive and negative frequency, so half of the spectrum resources and signal energy are wasted. The complex-carrier modulation uses the distinguishable positive frequency signal exp(iwt) and negative frequency signal exp(-iwt) as the carrier signals, they can carry different information, so the spectrum resources is full used, the complex-carrier demodulation does not lose signal energy, so the spectrum efficiency is improved.
In the frame of the Primary Wall Module prototype manufacturing for ITER, a consistent R and D phase was conducted in order to identify the industrial allowable tolerances and manufacturing problems which would occur when joining pieces by HIPping process during the PW module manufacturing. The purpose of this development was to give as industrial as possible manufacturing routes for joining together large Stainless Steel or DS-Copper pieces with Stainless Steel tubes and for bonding Beryllium tiles onto a curved component surface. The study concerned surface preparations, allowable gaps and joint geometry, Beryllium tile geometry, Titanium interlayer thickness, etc. This R and D phase also allowed the development and validation of different ultrasonic inspection tools needed for plate-plate, tube-plate, edge to edge plate bonding.
Midway Labs currently produces a 335x concentrator module that has reached as high as 19{percent} active area efficiency in production. The current production module uses the single crystal silicon back contact SunPower cell. The National Renewable Energy Lab has developed a multi junction cell using GalnP/GaAs technologies. The high efficiency ({gt}30{percent}) and high cell voltage offer an opportunity for Midway Labs to develop a tracking concentrator module that will provide 24 volts in the 140 to 160 watt range. This voltage and wattage range is applicable to a range of small scale water pumping applications that make up the bulk of water pumping solar panel sales. {copyright} {ital 1997 American Institute of Physics.}
I. S. Kirbis, P. Maxwell, M. S. Flear, K. Miller and M. Ibrahim External quality control for immunocytochemistry on cytology samples: a review of UK NEQAS ICC (cytology module) results Objective:- To date, external quality control for immunocytochemistry on cytology samples is provided only by the United Kingdom national external quality assessment service for immunocytochemistry and in situ hybridisation (UK NEQAS ICC & ISH). For the purpose of this study a retrospective analysis of a comprehensive collection of quality-related data regarding immunocytochemistry on cytology samples collected through this service was analysed. Methods:- The quality of immunocytochemical reactions, using on-line collected data, was analysed for the last 23 UK NEQAS ICC cytology module external quality asses...
A cooperative effort of the Center for Solar Energy and Hydrogen Research (ZSW) and Phototronics Solartechnik GmbH (PST) aimed at the transfer of highly efficient solar cells developed on a laboratory scale, to large-area thin-film solar modules suitable for production. This work was based on research and development at the Institute for Physical Electronics (IPE) of Stuttgart University and ZSW on one hand, and on the know-how of PST in regard to large-area module fabrication on the other hand. The various thin-film layers of the cells and modules comprize molybdenum as rear contact, copper-indium(gallium)-diselenide (CIGS) as absorber material, the combination of cadmium sulphide (CdS) and ZnO as window layer. To produce these layers on large areas (30x30 cm{sup 2}), equipment was constructed and procedures were developed. Monolithic series connection of cells, used in other thin-film technologies, was studied and ...
We report progress in an effort to develop and demonstrate a refuelable zinc/air battery for fleet electric vehicle applications. A refuelable module consisting of twelve bipolar cells with internal flow system has been refueled at rates of nearly 4 cells per minute refueling time of 10 minutes for a 15 kW, 55 kWh battery. The module is refueled by entrainment of 0.5-mm particles in rapidly flowing electrolyte, which delivers the particles into hoppers above each cell in a parallel-flow hydraulic circuit. The concept of user-recovery is presented as an alternative to centralized service infrastructure during market entry.
The assumed linear relationship between exposure to radiation and cancer incidence is questioned in this article. The current research data on radiation effects at the cellular level is reviewed, as are epidemiological studies of background radiation effects and health effects of populations exposed to low levels of radiation exposure via employment or medical treatments. Statistics reveal that threshold levels currently in force need to be reviewed. Some evidence of beneficial effects of low level radiation exposure effects of low level radiation exposure is also presented, and so regulations should be reviewed at an international level. (UK).
The most propagated mechanisms of stimulated radiation of electron beam such as Cherenkov one-particle and collective effects, ondulator and magnetic bremsshrahlung radiations, Doppler anomalous effect, Thompson and Raman scattering and radiation are discussed. Relation of spontaneous radiation mechanisms of individual electron and stimulated radiation effects in electron beams has been elucidated, grounds of linear electrodynamics of radiative beam instabilities are stated, and main mechanisms of their nonlinear stabilization are elucidated as well. Various simulated processes in electron beams are considered from the unique point of view using a simple mathematical apparatus and such physical laws as conservation and Newton laws.
Limestone slurry needs to move efficiently through a complex process, meaning that selecting the right pumps and valves is critical. The article discusses factors to consider in selecting pumps and values for flue gas desulfurization process in coal-fired power plants. 2 photos.
Economic and performance criteria that should be used in the selection of a scrubber system are presented. Selection should be based on the type of emissions put out by a plant and the removal efficiency required by pollution control standards. Costs and efficiencies for 10 different scrubber systems are reported. (10 diagrams)
Major advances in 'Energy and Materials Cycles' have been achieved in the removal of heavy metals from the solid residues of municipal waste incineration. It has been conclusively shown that the oxidation/reduction conditions established during the thermal treatment of filter ash have a decisive influence on the evaporation of groups of heavy metals. With respect to biomass gasification, studies have been carried out with respect to the best way of extracting pure hydrogen from the low calorific value gas that is typically obtained from a biomass gasifier. The overarching goal of the laboratory 'High Temperature Solar Technology' is the use of solar energy for the production of solar fuels, or for the reduction of CO{sub 2} emissions in large scale industrial processes that are conventionally carried out with the use of fossil fuels. In a short-term project targeted at the solar production of lime, highly encouraging results (98% degree of ...
Main topic of the project was the manufacturing of highly efficient GaAs-solar cells and the fabrication of concentrator cells. During this process significant progress was made with the material preparation, the solar cell technology and the material and process characterisation. This succeeded in the following efficiencies: - GaAs solar cell made by MOVPE technology: 22.9% on 4 cm{sup 2} (AM1.5g) - GaAs solar cell made by LPE-ER process: 22.8% on 4 cm{sup 2} (AM1.5g) - GaAs concentrator solar cell made by LPE-ER process: 24.9% at C=100xAM1.5d - GaAs concentrator module with fresnel lenses: Module efficiency 20.1% (under irradiation of 793 W/m{sup 2}). Another main focus was the epitaxy of GaAs on Si substrate. Two different approaches were investigated. Together with the cooperation partner ASE, Heilbronn a selective growth technology was developed that led to a decreased crack formation. By a simultanous optimization of ...
BackgroundFeature selection is an important pre-processing task in the analysis of complex data. Selecting an appropriate subset of features can improve classification or clustering...Full Text Available
The development of several DDT-resistant strains of Anopheles atroparvus is described. They were selected by larval treatment only (RL), selection of larval and adult females (RLAF),...Full Text Available
... TITLE (Include Security Classification) Sorption of Selected Volatile Organic Constituents of Jet Fuels and Solvents on Natural Sorbents from Gas ...
Sep 21, 2006 ... NASA has selected Air Products and Chemicals, Inc., Allentown, Pa., to design, furnish and install a plant to produce liquid nitrogen for ...
This poster describes single-molecule tracking and total internal reflection fluorescence microscopy. It discusses whether the carbohydrate-binding module (CBM) moves on cellulose, how the CBM binds to cellulose, and the mechanism of cellulosome assembly.
The effect of TP (triosephosphates:glyceraldehyde-3 phosphate, GAP, +dihydroxyacetone phosphate, DHAP) on respiration, phosphorylation and matrix ATP/ADP ratios of isolated oat mesophyll mitochondria...Full Text Available
AIM: To investigate the effects of transforming growth factor β1 (TGF-β1) on the differentiation of colonic lamina propria fibroblasts (CLPF) into myofibroblasts in vitro.METHODS:...Full Text Available
BackgroundProcessing of multimodal information is a critical capacity of the human brain, with classic studies showing bimodal stimulation either facilitating or interfering in perceptual...Full Text Available
Recent research has implicated the nucleus accumbens (NAc) in consolidating recently acquired goal-directed appetitive memories, including spatial learning and other instrumental processes. However,...Full Text Available
The mini-chromosome maintenance proteins Mcm2–7 are essential for DNA replication. They are loaded onto replication origins during G1 phase of the cell cycle to form a pre-replication complex...Full Text Available
OBJECTIVETo determine if ProL1, a member of the opiorphin family of genes, can modulate erectile physiology, as it encodes a peptide which acts as...Full Text Available
The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover,...Full Text Available
Two dimensional Fourier spectra of near-infrared images of galaxies provide a powerful diagnostic tool for the detection of spiral arm modulation in stellar disks. Spiral arm modulation may be understood in terms of interference patterns of outgoing and incoming density wave packets or modes. The brightness along a spiral arm will be increased where two wave crests meet and constructively interfere, but will be decreased where a wave crest and a wave trough destructively interfere. Spiral arm modulation has hitherto only been detected in grand design spirals (such as Messier 81). Spiral arm amplitude variations have the potential to become a powerful constraint for the study of galactic dynamics. We illustrate our method in two galaxies: NGC 4062 and NGC 5248. In both cases, we have detected trailing and leading m=2 waves with similar pitch angles. This suggests that the amplification mechanism is the WASER type II. In this ...
The canonical Wnt/β-catenin pathway plays a pivotal role in regulating embryogenesis and tumorigenesis by promoting cell proliferation. BAMBI (BMP and activin membrane-bound inhibitor) has...Full Text Available
The Fermilab Linac Upgrade is planned to increase the energy of the H- linac from 200 to 400 MeV. This is intended to reduce the incoherent space-charge tuneshift at injection into the 8 GeV Booster which can limit either the brightness or the total intensity of the beam. The Linac Upgrade will be achieved by replacing the last four 201.25 MHz drift-tube tanks which accelerate the beam from 116 to 200 MeV, with seven 805 MHz side-coupled cavity modules operating at an average axial field of abut 7.5 MV/m. This will allow acceleration to 400 MeV in the existing Linac enclosure. Each accelerator module will be driven with a klystron-based rf power supply. A prototype rf modulator has been built and tested at Fermilab, and a prototype 12 MW klystron is being fabricated by Litton Electron Devices. Fabrication of production accelerator modules is in progress. 8 figs., 4 tabs.
Milstar 2. (USA 115). 60A. Titan IV. Nov. 12, 1995. Install Docking Module on the Mir space. 396 km. Second of 9 planned flights. Space Shuttle Atlantis ...
Many growth factors and hormones modulate the reproductive status in mammals. Among these, insulin and insulin-like growth factor I (IGF-I) regulate the development of gonadal tissues. SH2-B has been...Full Text Available
Rate of dehydration greatly affects desiccation tolerance of recalcitrant seeds. This effect is presumably related to two different stress vectors: direct mechanical or physical stress because of the...Full Text Available
Assimilatory nitrate reductase activity (NRA) in crude spinach leaf (Spinacia oleracea) extracts undergoes rapid changes following fluctuations in photosynthesis brought about by changes...Full Text Available
Calculations of dose per monitor unit (D∕MU) are required in addition to measurements to increase patient safety in the clinical practice of proton radiotherapy. As in conventional photon and...Full Text Available
Computer-aided diagnosis of neural diseases from EEG signals (or other physiological signals that can be treated as time series, e.g., MEG) is an emerging field that has gained much attention in past...Full Text Available
A substantial proportion of lymph node-negative patients who receive adjuvant chemotherapy do not derive any benefit from this aggressive and potentially toxic treatment. However, standard histopathological...Full Text Available
This patent describes improvement in a system for stabilizing the operation of an electrical generator connected to a power distribution network of the type including a power system stabilizer for providing an oscillation signal having a value which normally represents generator oscillations and a modulator circuit responsive to input signals including the oscillation signal to provide a modulated output signal for varying generator excitation, means for checking for operational integrity of the power system stabilizer. It comprises: means for applying, to the power system stabilizer, a test signal of known amplitude and frequency, the test signal simulating generator oscillations and serving to produce a simulated oscillation signal for employment as the oscillation signal, means to store representations of time related values of the test signal; means to demodulate the modulated output signal to develop a demodulated ...
BackgroundPolymorphisms in Epidermal Growth Factor Receptor (EGFR) gene may influence EGFR production and/or activity, thereby modulating susceptibility to lung...Full Text Available
PurposeThe size of neuronal populations is modulated by gene variants that influence cell production and survival, in turn influencing neuronal connectivity, function,...Full Text Available
Motivation: The identification of gene regulatory modules is an important yet challenging problem in computational biology. While many computational methods have been proposed to identify...Full Text Available
Human skin is a local source of corticotropin-releasing hormone (CRH) and expresses CRH and CRH receptors (CRH-R) at mRNA and protein levels. Epidermal melanocytes respond to CRH by induction...Full Text Available
A number of studies have examined the functional roles of individual muscles during normal walking, but few studies have examined which are the primary muscles that respond to changes in external...Full Text Available
BackgroundCalcium signaling plays an important role in B lymphocyte survival and activation, and is critically dependent on the inositol-1,4,5-tris-phosphate-induced...Full Text Available
AbstractIntrathymic expression of tissue-restricted antigens (TRAs) has been viewed as the key element in the induction of central tolerance and recently, a central role for the autoimmune...Full Text Available
Mitochondrial heat shock protein 70 (mtHSP70) is found to play a primary role in cellular defense against physiological stress like exposure to environmental contaminants and helpful in the maintenance...Full Text Available
Studies have shown that the nervous system may adopt a control scheme in which synergistic muscle groups are controlled by common excitation patters, or modules, to simplify the coordination...Full Text Available
Cross-resistance to cefoxitin (FOX), chloramphenicol (CMP), and quinolones (nalidixic acid [NAL]) related to a putative efflux system overexpression has recently been reported for Klebsiella...Full Text Available
Inducible gene expression appears to be an essential event that couples light to entrainment of the master mammalian circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus....Full Text Available
BackgroundLipocalin 2 (Lcn2) is a bacteriostatic factor that may also modulate cellular function, however, little is known concerning the expression or role of Lcn2 in CNS inflammation....Full Text Available
Mammals possess multiple insulin-like growth factor (IGF) binding proteins (IGFBPs), and related proteins, that modulate the activity of insulin/IGF signalling (IIS), a conserved neuroendocrine signalling...Full Text Available
We have characterized the kinetic response of gene targets throughout the murine genome to transcriptional modulation by the glucocorticoid receptor (GR). In contrast to a model in which multiple genes...Full Text Available
Segments of the chick basilar papilla were isolated and maintained in culture medium. The sensory hair bundle of individual hair cells was observed with light microscopy and stimulated with a water...Full Text Available
Decitabine, an epigenetic modifier that reactivates genes otherwise suppressed by DNA promoter methylation, is effective for some, but not all cancer patients, especially those with solid tumors. It...Full Text Available
The murine γ-herpesvirus-68 (γHV68) establishes viral latency in dendritic cells (DCs). In the present study, we examined the specific consequences...Full Text Available
BackgroundClinical studies suggest that local wall shear stress (WSS) patterns modulate the site and the progression of atherosclerotic lesions. Computational fluid dynamics (CFD)...Full Text Available
Auxin autonomous growth of most crown gall tumor cells requires the expression of two auxin biosynthesizing genes (tms 1 and tms 2) from the T-DNA of Agrobacterium...Full Text Available
Auxin modulates diverse plant developmental pathways through direct transcriptional regulation and cooperative signaling with other plant hormones. Genetic and biochemical approaches have clarified...Full Text Available
Ethnopharmacological relevanceHLXL is a traditional Chinese medicine that has long been used in folk medicine for the treatment of chronic inflammatory diseases....Full Text Available
In order to maintain stable functionality in the face of continually changing input, neurones in the CNS must dynamically modulate their electrical characteristics. It has been hypothesized that in...Full Text Available
Orientation and movement relies on both visual and vestibular information mapped in separate coordinate systems. Here, we examine how coordinate systems interact to guide eye movements of rabbits....Full Text Available
In chemostat culture, the virulence of two strains of Legionella pneumophila was shown to be significantly (P < 0.05) reduced when the culture temperature was lowered from 37 to 24 degrees C....Full Text Available
Our increasing capabilities for quantitative hormone analysis and automated high resolution growth studies have allowed a reassessment of the classical Cholodny-Went hypothesis of gravitropism. According...Full Text Available
Animals in a variety of taxa discriminate between a greater quantity and a lesser quantity of the same object, an ability that is referred to as relative numerousness judgment. For example,...Full Text Available
γ-Aminobutyric acid (GABA)-ergic transmission is critical for normal cortical function and is likely abnormal in a variety of neuropsychiatric disorders. We tested the in...Full Text Available
We construct two families of refinements of the (projectivized) support variety of a finite dimensional module $M$ for a finite group scheme $G$. For an arbitrary finite group scheme, we associate a family of {\\it non maximal rank varieties} $\\Gamma^j(G)_M$, $1\\leq j \\leq p-1$, to a $kG$-module $M$. For $G$ infinitesimal, we construct a finer family of locally closed subvarieties $V^{\\ul a}(G)_M$ of the variety of one parameter subgroups of $G$ for any partition $\\ul a$ of $\\dim M$. For an arbitrary finite group scheme $G$, a $kG$-module $M$ of constant rank, and a cohomology class $\\zeta$ in $\\HHH^1(G,M)$ we introduce the {\\it zero locus} $Z(\\zeta) \\subset \\Pi(G)$. We show that $Z(\\zeta)$ is a closed subvariety, and relate it to the non-maximal rank varieties. We also extend the construction of $Z(\\zeta)$ to an arbitrary extension class $\\zeta \\in \\Ext^n_G(M,N)$ whenever $M$ and $N$ are ...
To successfully grow, neurons need to overcome the effects of hostile environments, such as the inhibitory action of myelin. We have evaluated the potential of exercise to overcome the intrinsic...Full Text Available
The programming of cellular networks to achieve new biological functions depends on the development of genetic tools that link the presence of a molecular signal to gene-regulatory activity. Recently,...Full Text Available
Changes in synaptic strength are believed to underlie learning and memory. We explore the idea that norepinephrine is an essential modulator of memory through its ability to regulate synaptic mechanisms....Full Text Available
BackgroundNeuropathic pain (NP) is partially mediated by neuroinflammatory mechanisms, and also modulates local neurogenic inflammation. Dietary lipids, in particular the total amount...Full Text Available
BackgroundCells dynamically adapt their gene expression patterns in response to various stimuli. This response is orchestrated into a number of gene expression modules consisting...Full Text Available
Caries is a multifactorial disease, and studies aiming to unravel the factors modulating its etiology must consider all known predisposing factors. One major factor is bacterial colonization,...Full Text Available
ATLAS is one of the four experiments which will take place at the LHC, the CERN future protons collider. This accelerator, which should start in 2007, will allow to continue the studies carried out by its predecessors, as the standard model Higgs boson and new physics searches. The very high luminosity -10 fb{sup -1} during the first three functioning years, then 100 fb{sup -1}- and the 14 TeV in the frame center will ease these studies. The Centre de Physique des Particules de Marseille took part in the ATLAS collaboration, taking in charge half of the End-cap electromagnetic calorimeter modules construction. The description of this sub-detector and the construction steps, in particular the electrical tests which allow the stacking validation, are presented in this document. These tests results, obtained for the live first production modules, are analysed. The pre-series module (module 0) performances, ...
Conjugated linoleic acid (CLA) has been the subject of extensive investigation regarding its possible benefits on a variety of human diseases. In some animal studies, CLA has been shown to have a beneficial...Full Text Available
BackgroundSteroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind....Full Text Available
Colour television is examined as an attempt to imitate the human visual system in image formation, spectral sensitivities, adaptation, contrast effects, signal processing, signal modulation, signal...Full Text Available
Germ cell tumor development in humans has been proposed to be part of testicular dysgenesis syndrome (TDS), which manifests as undescended testes, sterility, hypospadias, and, in extreme cases,...Full Text Available
We introduce cyclophosphamide-induced alopecia (CYP-IA) in C57BL-6 mice as a clinically relevant model for studying the biology of chemotherapy-induced alopecia and for developing anti-alopecia drugs....Full Text Available
Zinc modulates the activity of glutamic acid decarboxylase, the rate limiting enzyme in the synthesis of gamma-aminobutyric acid (GABA), which is a major inhibitory neurotransmitter. Low cerebrospinal...Full Text Available
New neurons are generated in the granule cell layer of the dentate gyrus (GCL) throughout adulthood. This process is modulated by many environmental and neurochemical factors. We previously...Full Text Available
A program was conducted to develop a pop-up artificial-foliage system compatible with the rural Maryland (summertime) background environment. The result of this Phase I effort was a self-expanding leaf module, a number of which are stored flat in a simple...
Stomatal movements depend on both ion influx and efflux; attainment of steady state apertures reflects modulation of either or both processes. The role of Ca2+ in those two processes was...Full Text Available
Recent evidence suggests a role for corticotropin-releasing factor (CRF) in the regulation of pair bonding in prairie voles. We have previously shown that monogamous and non-monogamous vole...Full Text Available
In the present work, we describe application of binary pseudo-random gratings (BPRG) and arrays (BPRA) as effective 1D and 2D test surfaces suitable for calibration of different surface profilometers, including a number of interferometric microscopes and scatterometers.
The super simulator 'SAMPSON' has been developed to show that there exist certain safety margins for light water reactors under hypothetical severe accidents and to investigate realistic measures of accident management by simulating accidents with a parallel computer. Heat-up of fuel rods and release of fission products from fuels are important factors to evaluate source terms. Models for fuel rod heat-up, hydrogen production due to cladding oxidation and cladding deformation and failure in the core region have been developed in the fuel rod heat-up analysis module. Fuel temperatures were calculated by solving the heat conduction equation. The calculated results for fuel temperature and hydrogen production were compared with CORA-13 experiment results. The comparisons showed prediction capability for the heat-up of fuel rods. The fission product release analysis module incorporates with models for fission product transport within fuel pellets, ...
Debris coolability in the lower plenum of the reactor pressure vessel is an important factor for evaluation of debris in-vessel retention. The debris coolability analysis module is developed for the accurate prediction of the safety margin of the present reactor vessels in a severe accident. The module calculates debris spreading and cooling through melting and solidification in combination with a temperature distribution and failure evaluation of the vessel wall. Debris spreading is solved by the explicit method on a quasi-three-dimensional scheme and debris coolability is solved on the basis of natural convection analysis. The calculation for spreading is compared with a water spreading experiment on the floor and the calculation for coolability is compared with a n-octadecane melting experiment in a rectangular vessel. The comparisons show capabilities for predictions of spearhead transportation in the debris spreading process and of melting ...
Debris coolability in the lower plenum of the reactor pressure vessel is an important factor for evaluation of debris in-vessel retention. The debris coolability analysis module is developed for the accurate prediction of the safety margin of the present reactor vessels in a severe accident. The module calculates debris spreading and cooling through melting and solidification in combination with a temperature distribution and failure evaluation of the vessel wall. Debris spreading is solved by the explicit method on a quasi-three-dimensional scheme and debris coolability is solved on the basis of natural convection analysis. The calculation for spreading is compared with a water spreading experiment on the floor and the calculation for coolability is compared with a n-octadecane melting experiment in a rectangular vessel. The comparisons show capabilities for predictions of spearhead transportation in the debris spreading process and of melting ...
The frequency dependence of the lasing power of a He-Ne laser was studied using the electrooptic effect in a KDP crystal. The gain profile of the power curve was found to differ noticeably between the high-frequency and low-frequency edges. (AIP). (AIP)
Muscarinic cholinergic receptors modulate dopaminergic function in brain pathways thought to mediate cocaine's abuse-related effects. Here, we sought to confirm and ...Full Text Available
IntroductionThe goal of this study was to identify serum markers that are modulated by treatment with golimumab with or without methotrexate (MTX) and are associated with clinical...Full Text Available
There is a growing evidence that serotoninergic systems modulate dopaminergic neurotransmission. We analyzed the association between the variations in the brain tryptophan hydroxylase 2 (TPH2)...Full Text Available
Chagas disease, caused by infection with Trypanosoma cruzi, is an important cause of cardiovascular disease. It is increasingly clear that parasite-derived prostaglandins potently modulate...Full Text Available
BackgroundThe successful interaction of bacterial pathogens with host tissues requires the sensing of specific chemical and physical cues. The human gut contains a huge number of...Full Text Available
Ataxin-3, the protein involved in Machado-Joseph disease, is able to bind ubiquitylated substrates and act as a deubiquitylating enzyme in vitro, and it has been involved in the modulation of protein...Full Text Available
Abs facilitate humoral immunity via the classical mechanisms of opsonization, complement activation, Ab-dependent cellular cytotoxicity, and toxin/viral neutralization. There is also evidence that some...Full Text Available
Background/AimTobacco use reduces the effect of non-surgical periodontal therapy. Host-modulation with low-dose doxycycline (LDD) might favour repair and promote...Full Text Available
Developing cortex generates endogenous activity that modulates the formation of functional units, but how this activity is altered to support mature function is poorly understood. Using recordings...Full Text Available
Pestiviruses are positive-strand RNA viruses closely related to human hepatitis C virus. Gene expression of these viruses occurs via translation of a polyprotein, which is further processed by cellular...Full Text Available