radiation oncology treatment: Topics by WorldWideScience.org

Radiation Therapy and Psychological Distress in Gynecologic Oncology Patients: Outcomes and Recommendations for Enhancing Adjustment

Cancer and Tobacco Abuse

2007-10-29

2

Dosimetric considerations for patients with HIP prostheses undergoing pelvic irradiation. Report of the AAPM Radiation Therapy Committee Task Group 63

SummaryRadiotherapy is used commonly in the treatment of gynecologic malignancies. Many patients experience emotional distress prior to the initiation of radiotherapy, during...Full Text Available

1986-01-01

3

Radiation Dosimetry considerations in the safe administration of therapeutic radiopharmaceuticals

This document is the report of a task group of the Radiation Therapy Committee of the AAPM and has been prepared primarily to advise hospital physicists involved in external beam treatment of patients with pelvic malignancies who have high atomic number (Z) hip prostheses. The purpose of the report is to make the radiation oncology community aware of the problems arising from the presence of these devices in the radiation beam, to quantify the dose perturbations they cause, and, finally, to provide recommendations for treatment planning and delivery. Some of the data and recommendations are also applicable to patients having implanted high-Z prosthetic devices such as pins, humeral head replacements. The scientific understanding and methodology of clinical dosimetry for these situations is still incomplete. This report is intended to reflect the current state of ...

2003-06-01

4

The course, diagnosis and treatment of Ewing's sarcoma of the rib in children

A set of eight questions was put to advanced nuclear medicine physicians-in-training participating in a continuing assessment exercise in practical therapeutic nuclear oncology. Using the particular example of {sup 131}I-MIBG treatment of neuroblastoma in children, the questions were directed to the rationale of therapy and the contribution of other forms of treatment to toxic effects. The best answer to the questions are reproduced together with an introduction by the examiner, Dr. H. Turner. tabs.

1995-12-01

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Current Role and Future Perspectives of Magnetic Resonance Spectroscopy in Radiation Oncology for Prostate Cancer

Advances in the diagnosis of Ewing's sarcoma of the rib were considered and retrospective analysis of the treatment of 32 patients (76% of them were children at the age of 10-15 y.o.) in the clinic of children oncology was performed. It was shown that the diagnosis of Ewing's sarcoma of the rib in children ought to be combined taking into account the course, morphology and radiation examination techniques. Most optimum treatment consisted of combined therapy (cyclic polychemotherapy, lesion focus irradiation at the summary focus dose of 57 Gy, surgery with subsequent polychemotherapy for not less than 1.5 years

1997-11-18

6

Relevance of circulating nucleosomes and oncological biomarkers for predicting response to transarterial chemoembolization therapy in liver cancer patients

Prostatic neoplasms are not uniformly distributed within the prostate volume. With recent developments in three-dimensional intensity-modulated and imageguided radiation therapy, it is possible to treat...Full Text Available

2007-06-01

7

Phase II Evaluation of Paclitaxel and Carboplatin in the Treatment of Carcinosarcoma of the Uterus: A Gynecologic Oncology Group Study

BackgroundTransarterial chemoembolization (TACE) therapy is an effective locoregional treatment in hepatocellular cancer (HCC) patients. For early modification of therapy, markers...Full Text Available

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PurposePlatinum and taxane compounds have demonstrated activity in uterine carcinosarcoma (malignant mixed Mullerian tumor). Ifosfamide plus paclitaxel is the regimen with established...Full Text Available

2010-06-01

9

Radiobiology

Use of a convolution/superposition-based treatment planning system for dose calculations in the kilovoltage energy range

This text-book (electronic book - multi-media CD-ROM) constitutes a course-book - author's collection of lectures. It consists of 13 lectures in which the reader acquaints with the basis of radiobiology: Introduction to radiobiology; Physical fundamentals of radiobiology; Radiation of cells; Modification of radiation damage of cells; Reparation of radiation damage of cells; Radiation syndromes and their modification; Radiation injury; Radiation damage of tissues; Effect of radiation on embryo and fetus; Biological effects of incorporated radionuclides; Therapy of acute irradiation sickness; Delayed consequences of irradiation; Radiation oncology and radiotherapy. This course-book may be interesting for students, post-graduate students of chemistry, biology, physics, medicine as well as for teachers, ...

10

Proposal of procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions; Proposta de procedimentos para evitar erros em radioterapia baseados em licoes aprendidas de exposicoes acidentais

A number of procedures in diagnostic radiology and cardiology make use of long exposures to x-rays from fluoroscopy units. Although numerous studies have been performed to measure or calculate skin dose from these procedures, there have only been a handful of studies to determine the dose to the other organs. This thesis was focused on devising a method to calculate the absorbed dose to underlying tissues and organs. The work was performed in several stages. First, a commercial convolution/superposition-based treatment planning system used in radiation oncology was modified and complemented to make it usable with the low energies of x-rays used in diagnostic radiology. This required generation of energy deposition kernels in the kilovoltage energy range. The kernels were generated using the EGS4 Monte Carlo system of codes and added to the treatment planning system. The treatment ...

2001-03-01

11

Conformal radiation therapy: technical requirements and clinical applications

In order to consider some procedures to prevent errors in radiotherapy based in learned lessons of accidental expositions and in accordance with information contained in international reports elaborated by International Atomic Energy Agency (IAEA) and of the data base availability by the European group Radiation Oncology Safety Information System (ROSIS) on the events, a research of the occurred errors was performed. For the evaluation of the incidents a data base based in the ROSIS and added plus a parameter was created 'type of error'. All the stored data make possible the evaluation of the 839 incidents in terms of frequency of the type of error, the process of detention, the number of reached patients and the degree of severity. Of the 50 types of found errors, the type of error more frequently was 'incorrect treatment coordinate', confirmed with the data of literature and ...

2007-07-01

12

The Results of Curative Concurrent Chemoradiotherapy for Anal Carcinoma

Conformal radiation therapy represents a considerable and attractive challenge in oncology. Its aim is mainly to improve local control by increasing the dose with an acceptable rate of complications. This work overviews the world literature on this subject. The technical and theoretical requirements are highlighted. These requirements include a precise definition of the target volume by digital imaging (essentially CT scan), but also clear view of the target volume and the organs at risk, a specific collimation of the beam, 3-D dose calculations, optimization procedures, and a rigid immobilization of the patient with verification of his position. Moreover, the clinical applications of conformal radiation therapy are reviewed and discussed. (authors). 80 refs., 1 tab.

1995-01-01

13

Multiple courses of high-dose total skin electron beam therapy in the management of mycosis fungoides

To evaluate the predictive factors for treatment response and prognostic factors affecting survival outcomes after concurrent chemoradiotherapy (CCRT) for patients with anal squamous cell carcinoma. Medical records of forty two patients with histologically confirmed analsquamous cell carcinoma, who had complete CCRT between 1993 and 2008, were reviewed retrospectively. Median age was 61.5 years (39-89 years), and median radiotherapy (RT) dose was 50.4 Gy (30.0-64.0 Gy). A total of 36 patients had equal to or less than T2 stage (85.7%). Fourteen patients (33.3%) showed regional nodal metastasis, 36 patients (85.7%) were treated with 5-fluorouracil (5-FU) plus mitomycin, and the remaining patients were treated by 5-FU plus cisplatinum. The median follow--up time was 62 months (2-202 months).The 5-year overall survival, locoregional relapse-free survival, disease-free survival, and colostomy-free survival rates were 86.0%, 71.7%, 71.7%, 78.2%, respectively. Regarding ...

2010-11-15

14

Multi-modality treatment of primary nonresectable intrahepatic cholangiocarcinoma with "1"3"1I anti-CEA--a Radiation Therapy Oncology Group Study

Purpose: A retrospective analysis was undertaken to determine the indications for, the efficacy of, and the long-term complications of two courses of total skin electron beam therapy for mycosis fungoides. Methods and Materials: A retrospective analysis of 15 patients with the pathologic diagnosis of mycosis fungoides treated in the Department of Radiation Oncology at Stanford University Medical Center between 1968 and 1990 was performed. All patients received two courses of high-dose electron beam therapy to the skin. The mean dose for the total skin treatment for the first course was 32.6 Gy and 23.4 Gy for the second course of treatment. Results: Following the first course of total skin electron beam therapy, 11 of 15 had a complete response, with a mean duration of 11.6 months. All patients received adjuvant therapies between the first and second courses of high-dose total skin electron beam ...

1995-07-30

15

Can intensity-modulated radiation therapy of the paraaortic region overcome the problems of critical organ tolerance?

Thirty-seven patients with primary nonresectable intrahepatic cholangiocarcinoma (57% with prior treatment and/or metastasis) were prospectively treated with external radiation, chemotherapy, and "1"3"1I labelled anti-CEA. Therapy began in all trials with whole liver irradiation (21.0 Gy, 3.0 Gy/Fx, 4 days/week, 10 MV photons) with alternate treatment day chemotherapy (Adriamycin, 15 mg + 5-FU, 500 mg). One month after external beam therapy, chemotherapy was given (Adriamycin, 15 mg + 5-FU, 500 mg) followed the next day by the first administration of "1"3"1I anti-CEA. The treatment schedule used was 20 mCi day 0; 10 mCi day 5 as an outpatient. This schedule was derived from tumor dose estimates which indicated that 20 mCi (8-10 mCi/mg IgG) was sufficient to achieve tumor saturation with a tumor effective half-life of 3 to 5 days, depending upon the species of animal from which the antibody was obtained. ...

16

Ewing's sarcoma. Evaluation of radiotherapy and control of the primary tumor

Background and purpose: the recent RTOG guidelines for future clinical developments in gynecologic malignancies included the investigation of dose escalation in the paraaortic (PO) region which is, however, very difficult to target due to the presence of critical organs such as kidneys, liver, spinal cord, and digestive structures. The aim of this study was to investigate intensity-modulated radiotherapy's (IMRT) possibilities of either increasing, in a safe way, the dose to 50-60 Gy in case of macroscopic disease or decreasing the dose to organs at risk (OR) when treatment is given in an adjuvant setting. Material and methods: the dosimetric charts of 14 patients irradiated to the PO region at the department of radiation oncology, university hospital of Liege, Belgium, in 2000 were analyzed in order to compare six-field conformal external-beam radio-therapy (CEBR) and five-beam IMRT approaches. Both CEBR and IMRT ...

2005-03-01

17

A multidisciplinary study investigating radiotherapy in Ewing's sarcoma: end results of POG no. 8346

From 1964 to 1973 at the Institute of Oncology and Radiobiology, Havana City, 18 clinical histories were studied, all of them from patients with Erwing's sarcoma, histologically diagnosticated by biopsy. Age, sex, race, traumatism background, hemogram disturbances, radiographic signs, primary tumor localization, and early treatment, were exposed. Early treatment in 14(83%) patients as radiotherapy. Local recurrence or metastasis was presented in 10(55,5%) patients during the two first years following attack treatment. Five (35,7%) patients was the survival rate within five years starting early treatemt. After five years, three (21,4%) patients were alive: for 18 and 14 year, and 64 month period; two patients died at 62 and 64 months. It is concluded that this survival may be increased by initial behaviour enclosed at the technologic therapeutic patterns of the the Institute of ...

18

The reirradiation of the cavum cancer. Experience of the oncology center Ibn-Rochd of Casablanca (C.O.I.R.); La reirradiation du cancer du cavum. Experience du centre d'oncologie Ibn-Rochd de Casablanca (COIR)

Purpose: To determine if involved field radiation (IF) is equivalent to standard whole bone radiation (SF) in local tumor control; to establish patterns of failure following treatment; and to determine response, event-free survival (EFS), and overall survival rates from multidisciplinary therapy in Ewing's sarcoma. Methods and Materials: Between 1983 and 1988, 184 children with Ewing's sarcoma were enrolled onto Pediatric Oncology Group 8346 (POG 8346). A total of 178 (97%) met eligibility criteria; 6 had pathology other than Ewing's sarcoma. Induction chemotherapy of cyclophosphamide/doxorubicin (adriamycin )(C/A) x 12 weeks was followed by local treatment either surgery or radiation therapy and C/A, dactinomycin, and vincristine for 50 weeks. Resection was advised for patients with small primary tumors if accomplished without functional loss. Forty patients ...

1998-08-01

19

The Use of Medical Images in Planning and Delivery of Radiation Therapy

The radiotherapy is the prime treatment for the cavum cancer. It is also useful to treat the tumor recurrences, in this case the reirradiation stays the only efficient therapy option to give a correct local control. The reirradiation, exclusive or in association with other therapies can contribute to the local control of cavum cancer recurrences with a survival rate at five years of 36 to 58%. (N.C.)

2006-11-15

20

Can intensity-modulated radiation therapy of the paraaortic region overcome the problems of critical organ tolerance?

Abstract The authors provide a survey of how images are used in radiation therapy to improve the precision of radiation therapy plans, and delivery of radiation treatment. In contrast...Full Text Available

1997-09-01

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Treatment of persons exposed in radiation accidents or nuclear explosions. Omhaendertagande av skadade vid radiakolyckor och kaernvapenexplosioner

Background and purpose: the recent RTOG guidelines for future clinical developments in gynecologic malignancies included the investigation of dose escalation in the paraaortic (PO) region which is, however, very difficult to target due to the presence of critical organs such as kidneys, liver, spinal cord, and digestive structures. The aim of this study was to investigate intensity-modulated radiotherapy's (IMRT) possibilities of either increasing, in a safe way, the dose to 50-60 Gy in case of macroscopic disease or decreasing the dose to organs at risk (OR) when treatment is given in an adjuvant setting. Material and methods: the dosimetric charts of 14 patients irradiated to the PO region at the department of radiation oncology, university hospital of Liege, Belgium, in 2000 were analyzed in order to compare six-field conformal external-beam radio-therapy (CEBR) and five-beam IMRT approaches. Both CEBR and IMRT ...

2005-03-01

22

Radiation Therapy in Treating Patients With Prostate Cancer

The report gives general principles of treatment and care of casualties caused by radiation accidents or nuclear explosions.

1991-01-01

23

Interinstitutional Variations in Planning for Stereotactic Body Radiation Therapy for Lung Cancer

Prostate Cancer; Psychosocial Effects of Cancer and Its Treatment; Radiation Toxicity; Sexual Dysfunction and Infertility

2011-09-13

24

British Library Electronic Table of Contents (United Kingdom)

Purpose: The aim of this study was to assess interinstitutional variations in planning for stereotactic body radiation therapy (SBRT) for lung cancer before the start of the Japan Clinical Oncology Group (JCOG) 0403 trial.Methods and Materials: Eleven institutions created virtual plans for four cases of solitary lung cancer. The created plans should satisfy the target definitions and the dose constraints for the JCOG 0403 protocol.Results: FOCUS/XiO (CMS) was used in six institutions, Eclipse (Varian) in 3, Cadplan (Varian) in one, and Pinnacle3 (Philips/ADAC) in one. Dose calculation algorithms of Clarkson with effective path length correction and superposition were used in FOCUS/XiO; pencil beam convolution with Batho power law correction was used in Eclipse and Cadplan; and collapsed co...

2007-01-01

25

Imaging pharmacodynamics in oncology. The potential significance of 'flares'

Successful treatment of stereotactic body radiation therapy combined with transarterial chemolipiodolization for hepatocellular carcinoma with biliary obstruction.

The clinical use of "1"8F-fluorodeoxyglucose (FDG) positron emission tomography in monitoring anticancer treatment is expanding. At the same time a number of radiotracers aiming to image different aspects of tumour biology such as proliferation and apoptosis are being developed. However, the factors determining changes of radiotracer uptake parameters in response to treatment are not well understood. In many cases, cellularity may be the primary determinant of changes of FDG uptake and may confound the interpretation of metabolic changes. Early imaging assessments have in some cases showed transient increases of uptake parameters, commonly termed 'flares', which are likely to be unaffected by cellularity and directly reflect pharmacodynamics at a cellular level. In this review a number of settings where molecular imaging 'flares' have been described are discussed. Such changes may often be clinically informative and warrant careful study as ...

2010-04-01

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Enteral nutrition with cosilate and full parenteral nutrition in multimodality treatment of late radiation injuries of large intestine

Full Text Available

2011-03-01

27

Multiscale registration of planning CT and daily cone beam CT images for adaptive radiation therapy

Short note.

1989-06-01

28

The effects of cosmic radiation on implantable medical devices

Adaptive radiation therapy (ART) is the incorporation of daily images in the radiotherapy treatment process so that the treatment plan can be evaluated and modified to maximize the amount of radiation...Full Text Available

2009-01-01

29

Application of gamma radiation

Metal oxide semiconductor (MOS) integrated circuits, with the benefits of low power consumption, represent the state of the art technology for implantable medical devices. Three significant sources of radiation are classified as having the ability to damage or alter the behavior of implantable electronics; Secondary neutron cosmic radiation, alpha particle radiation from the device packaging and therapeutic doses(up to 70 G{gamma}) of high energy radiation used in radiation oncology. The effects of alpha particle radiation from the packaging may be eliminated by the use of polyimide or silicone rubber die coatings. The relatively low incidence of therapeutic radiation incident on an implantable device and the use of die coating leaves cosmic radiation induced secondary neutron single event upset ...

1996-12-31

30

Safety of pull-type and introducer percutaneous endoscopic gastrostomy tubes in oncology patients: a retrospective analysis

Described and discussed in this paper are radiation processes and their advantages over the conventional techniques. Radiation sterilization of medical products, food irradiation, wood plastic composites, and radiation treatment of sewage and waste waters are presented. The Philippine experience in using these technologies, its problems and barriers are also given. (ELC).

1985-12-10

31

Oncology data management in the UK--BODMA's view. British Oncology Data Managers Association.

BackgroundPercutaneous endoscopic gastrostomy (PEG) allows long-term tube feeding. Safety of pull-type and introducer PEG placement in oncology patients with head/neck or oesophageal...Full Text Available

32

Robot-Assisted Gynecologic Oncology Surgery

Over the past 10 years, the original partnership of clinician and statistician for the running of clinical research projects, especially clinical trials, has come to be supplemented by the data manager...Full Text Available

1994-09-01

33

Medline Plus

... these flat monitors don't really do you justice. You actually have a much better view than ...

34

Combined Radiation and Thermal Injury after Nuclear Attack

Orbital lymphoma: Role of radiation

... Except for isolated radiation accidents over the ensuing years, little practical experience has been gained in the treatment of thermal injuries ...

2011-05-13

35

Anxiety and Cancer Treatment: Response to Stressful Radiotherapy

The purpose of this article is to review the literature for clinical presentation, treatment, outcome and complications of using radiotherapy for the treatment of orbital lymphoma. For this, MEDLINE,...Full Text Available

2009-03-01

36

Radiation, adriamycin, and skin reactions: effects of radiation and drug fractionation, hyperthermia, and tetracycline. [X rays

Previous research with individuals undergoing surgery or diagnostic procedures provided a conceptual framework for analysis of radiation therapy, a common form of cancer treatment. The present...Full Text Available

1984-01-01

37

Radiation therapy alone versus radiation therapy and chemotherapy in the management of Hodgkin's disease.

The effect of adriamycin in combination with radiation on the skin reactions of mouse feet has been examined under a variety of experimental conditions including: (a) hyperthermic treatment of the foot immediately following adriamycin administration, with the former given either just before or just after x irradiation, and (b) fractionated treatments of drug and radiation in a variety of sequences over an 18-day period. In the case of the most severe hyperthermic treatment, no increased radiation reactions were observed in the presence of adriamycin. However, in the case of the less severe hyperthermic treatment a small but significant increase in skin reactions was observed. In the study of fractionated drug and radiation treatments, an enhancement of reaction in those animals receiving combined ...

1981-06-01

38

Radiations against tumors: a bit old-fashioned?; Rayonnements contre tumeurs: un rien demode?

Forty-four patients with histologically proven Hodgkin's disease underwent initial treatment with extended-field radiation therapy. Nineteen of these patients also received combination chemotherapy....Full Text Available

1990-02-01

39

Combined Modality Treatment for Prostate Cancer With Dynamic Adaptive Radiation Therapy Using Four-Dimensional Image-Guided Intensity-Modulated Radiation Therapy and Brachytherapy

The proton therapy gives an irradiation adapted to the shape and the depth of tumors ( eyes, head and neck) with a millimetric, even sub millimetric precision for the ophthalmological tumors. It is equally an excellent tool for the pediatrics tumors. For numerous treatments in France the proton therapy is associated to the photons treatments (x radiation). however, others physical treatments could modulate the medical offer, such thermal therapy or treatments by ultrasonic waves. (N.C.)

2004-09-01

40

British Library Electronic Table of Contents (United Kingdom)

Prostate cancer can be successfully treated using dynamic adaptive external beam radiation techniques along with interstitial brachytherapy to deliver curative therapies with low urinary, rectal and erectile function morbidity. Through the use of sophisticated, state-of-the art radiographic imaging for staging and treatment planning, a precise, individual design for treatment is accomplished. Symptom management and patient education are of paramount importance and are integrated throughout the treatment process.

2009-01-01

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Hyperfractionated radiotherapy with simultaneous chemotherapy in Ewing's sarcoma

The benefits of low level radiation

In 1981, the German Society of Pediatric Oncology initiated a multi-institutional study for the treatment of Ewing's sarcoma. The protocol (Cooperative Ewing's Sarcoma Study, CESS 81) consisted of four courses of a four-drug-regimen (VACA), each course taking nine weeks. Local therapy (radical surgery or resection plus irradiation or radiotherapy alone) was performed after the second course. The results of CESS 81 can be summarized as follows: VACA-chemotherapy is effective in controlling systemic disease. Initial tumor mass and response to initial chemotherapy are of major prognostic value for local control and survival. Permanent local control is a problem, especially in irradiated patients. The high local failure rate in irradiated patients in CESS 81 could be attributable to the following reasons: Late start of local therapy (after 18 weeks of chemotherapy), uneven distribution of prognostic parameters: Large tumors were more often ...

42

Proton beam therapy for cancer in deep-seated organs

The assumed linear relationship between exposure to radiation and cancer incidence is questioned in this article. The current research data on radiation effects at the cellular level is reviewed, as are epidemiological studies of background radiation effects and health effects of populations exposed to low levels of radiation exposure via employment or medical treatments. Statistics reveal that threshold levels currently in force need to be reviewed. Some evidence of beneficial effects of low level radiation exposure effects of low level radiation exposure is also presented, and so regulations should be reviewed at an international level. (UK).

1997-06-01

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The use of EPID-measured leaf sequence files for IMRT dose reconstruction in adaptive radiation therapy

Radiation therapy has shown definite technical improvement due to application of proton beam irradiation. Clinical results of proton beam therapy also suggested enlargement of indication ranges in radial treatment and decrease of post radiation damages of the treatment of cancers in deep-seated organs. Inprovement of result in cancer therapy could be expected by this treatment technique in the future.

1988-10-01

44

Radiation modification of vascular prostheses

For intensity modulated radiation treatment (IMRT) dose reconstruction, multileaf collimator (MLC) log files have been shown applicable for deriving delivered fluence maps. However, MLC log files are...Full Text Available

2008-11-01

45

Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol

The radiation method has been employed for the modification of the surface of vascular prostheses by means of acrylamide. As a result of the treatment, the tightness of the prosthesis walls was improved as well as an increase of surface hydrophilicity. Upon autoclaving, stable binding of polyacrylamide to prostheses is achieved. (author).

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Optimization of extracranial stereotactic radiation therapy of small lung lesions using accurate dose calculation algorithms

PurposeRadiation-induced heart disease (RIHD) is a severe side effect of thoracic radiotherapy. This study examined the effects of PTX and α-tocopherol on...Full Text Available

2008-09-01

47

Comparing Radiation Treatments Using Intensity-Modulated Beams, Multiple Arcs and Single Arc

BackgroundThe aim of this study was to compare and to validate different dose calculation algorithms for the use in radiation therapy of small lung lesions and to optimize the treatment...Full Text Available

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PurposeA dosimetric comparison between multiple static-field intensity-modulated radiation therapy (IMRT), multi-arc intensity-modulated arc therapy (IMAT) and single-arc...Full Text Available

2010-04-01

49

Motion management with phase-adapted 4D-optimization

PMID:18640506

2008-08-01

50

Laser Technology for Remote Treatment of Atomic Equipment

Cancer treatment with ionizing radiation is often compromised by organ motion, in particular for lung cases. Motion uncertainties can significantly degrade an otherwise optimized treatment plan....Full Text Available

2010-09-07

51

International Science & Technology Center (ISTC)

Investigation of Interaction of Laser Radiation with Radioactive Deposits on the metal Surface and Creation of Experimental Stand for Development of Laser Technology for Remote Treatment of Materials Contaminated with Radioactive Substances at the Atomic Power Plants

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Comparing two strategies of dynamic intensity modulated radiation therapy (dIMRT) with 3-dimensional conformal radiation therapy (3DCRT) in the hypofractionated treatment of high-risk prostate cancer

Medulloblastoma: Are We Overtreating?

BackgroundTo compare two strategies of dynamic intensity modulated radiation therapy (dIMRT) with 3-dimensional conformal radiation therapy (3DCRT) in the setting of hypofractionated...Full Text Available

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Fractionated stereotactic radiotherapy in the treatment of pituitary macroadenomas

Modern advances in the concept and the techniques of megavoltage radiation therapy have revolutionized the treatment of medulloblastoma. Five-year survivals of 50 to 70 percent are achieved by craniospinalaxis...Full Text Available

1985-02-01

54

Application of low dose radiation for preservation of sea foods

BackgroundThe use of fractionated stereotactic radiotherapy (fsrt) has evolved with technical advances in noninvasive immobilization, radiation delivery, and image guidance....Full Text Available

2008-12-01

55

Radiotherapy quality assurance review in a multi-center randomized trial of limited-disease small cell lung cancer: the Japan Clinical Oncology Group (JCOG) trial 0202

Treatment of food with low doses of gamma radiation has been recognized to have two main advantages. These consist of: (1) improvement of food safety by elimination of pathogens and (2) reduction of microbial spoilage and extension of shelf life of perishable items by reducing the number of viable spoilage organisms. Studies during the last few decades have conclusively proved the beneficial effects of radiation with respect to fishery products. The three potential areas of application to fish products include: (i) radurization for shelf life extension (ii) radicidation to eliminate food borne pathogens in the products and (iii) radiation treatment to dried products to control insects.

1994-03-01

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Radiological concepts in radiotherapy

BackgroundThe purpose of this study was to analyze the radiotherapy (RT) quality assurance (QA) assessment in Japan Clinical Oncology Group (JCOG) 0202, which was the first trial...Full Text Available

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New concepts in risk assessment for patients with radiological treatment

The atomic explosions in Hiroshima and Nagasaki made the name radiation itself become a nightmare. Notwithstanding this, radiation continued to serve the mankind specially in diagnosis of several human diseases and in the treatment of intractable malignancies. With their latest research tools biologists have now shown a significant shift in the earlier paradigm; even the concept that radiation initiates cancer appears to be no longer tenable. On the contrary, selective radiation doses inhibit growth of cancer cells and radiation in combination with many chemotherapeutic drugs, radiosensitizing chemicals and/or hyperthermia, is emerging as a new modality for cancer treatment which offers high therapeutic advantages. In addition, the deleterious effects of radiation can now be strategically counter poised by the use of ...

58

Effect of rapid thermal annealing on radiation hardening of MOS devices

In radiation risk assessment it must be differentiated between somatic and genetic effect on the one hand as well as between stochastic and non-stochastic effect on the other. According to definitions of the ICRP report 26 the limit for the dose equivalent of all tissues prevents non-stochastic radiation effects. With stochastic radiation effects probably exist no threshold doses; therefore the ALARA principle must be applied concerning radiation protection. The individual risk by stochastic radiation effects in its linear, linear-quadratic and quadratic extrapolations, respectively, is discussed in detail. The effective stochastic dose equivalent (H/sub eff/) as well as collective dose and collective damage are outlined.

1986-01-01

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Interinstitutional Variations in Planning for Stereotactic Body Radiation Therapy for Lung Cancer

The influence of RTA (Rapid Thermal Anneal) treatment on MOS radiation hardness is demonstrated and compared with classical furnace treatment. In the case of the RTA, the oxide trapped charge is found to depend on: (i) the anneal temperature as expected, data are in good agreement with a recently developed model of oxygen out-diffusion; (ii) the location across the wafer with a radial dependence, results could be related to stress induced by thermal gradient.

1995-07-17

60

What, why, and when we image: considerations for diagnostic imaging and clinical research in the Children's Oncology Group

Purpose: The aim of this study was to assess interinstitutional variations in planning for stereotactic body radiation therapy (SBRT) for lung cancer before the start of the Japan Clinical Oncology Group (JCOG) 0403 trial. Methods and Materials: Eleven institutions created virtual plans for four cases of solitary lung cancer. The created plans should satisfy the target definitions and the dose constraints for the JCOG 0403 protocol. Results: FOCUS/XiO (CMS) was used in six institutions, Eclipse (Varian) in 3, Cadplan (Varian) in one, and Pinnacle3 (Philips/ADAC) in one. Dose calculation algorithms of Clarkson with effective path length correction and superposition were used in FOCUS/XiO; pencil beam convolution with Batho power law correction was used in Eclipse and Cadplan; and collapsed cone convolution superposition was used in Pinnacle3. For the target volumes, the overall coefficient of variation was 16.6%, and the interinstitutional ...

2007-06-01

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Treatment of cancer of the pancreas by intraoperative electron beam therapy: physical and biological aspects

Success in improving treatment outcomes in childhood cancer has been achieved almost exclusively through multicenter and multidisciplinary clinical and applied research over several decades. While biologically rational as well as empirical approaches have led to combination chemotherapy and multimodality approaches to therapy, which have given rise to evidence-based practice standards, similar scientific rigor has not always been as evidently applied to modalities utilized to assess initial disease burden and, more important, response to investigational approaches to therapy. As the empirical approach to therapeutic advances has likely maximized its benefit, future progress will require translation of biologic discovery most notably from the areas of genomics and proteomics. Hence, attempts to improve efficacy of therapy will require a parallel effort to minimize collateral damage of future therapeutic approaches, and such a parallel approach will mandate the ...

2009-02-15

62

Treatment of cancer of the pancreas by intraoperative electron beam therapy: physical and biological aspects

Radiation therapy has had a significant and an expanded role in the management of cancer of the pancreas during the last decade. In particular, for locally advanced disease, radiation therapy has improved the median survival of patients to 1 year. Intraoperative electron beam therapy has been applied to unresectable and resectable pancreatic cancer in an attempt to enhance local control of disease and to improve patient survival. This paper presents a survey of the role of radiation therapy in treatment of cancer of the pancreas, provides information on the radiobiological aspects of this treatment modality and details the physical and dosimetric characteristics of intraoperative radiation therapy with electrons. Presented are the design specifics of an applicator system, central axis beam data, applicator parameters, dose distribution data, shielding, ...

1989-01-01

63

Radiation preservation of foods of plant origin. Part IV. Subtropical fruits: citrus, grapes, and avocados

Radiation therapy has had a significant and an expanded role in the management of cancer of the pancreas during the last decade. In particular, for locally advanced disease, radiation therapy has improved the median survival of patients to 1 year. Intraoperative electron beam therapy has been applied to unresectable and resectable pancreatic cancer in an attempt to enhance local control of disease and to improve patient survival. This paper presents a survey of the role of radiation therapy in treatment of cancer of the pancreas, provides information on the radiobiological aspects of this treatment modality and details the physical and dosimetric characteristics of intraoperative radiation therapy with electrons. Presented are the design specifics of an applicator system, central axis beam data, applicator parameters, dose distribution data, shielding, ...

64

X-ray imaging dose due to the digital imaging devices used in radiation therapy for patient positioning and repositioning: How to take it into account?; Les doses dues a l'imagerie numerique pour le controle de positionnement du patient en radiotherapie: comment les prendre en compte?

Current information on the use of ionizing radiation for improving the storage of subtropical fruits like citrus, grapes, and avocados is reviewed. The feasibility of applying radiation either alone or in combination with other physical or chemical treatments for the control of postharvest fungal diseases is considered. Irradiation effects on the physiology of the fruits as related to respiration, ethylene evolution, changes in major chemical constituents, and quality are discussed. The recent trends in the possible use of irradiation as an alternative treatment to chemical fumigants for disinfestation of citrus and avocados and the prospects for the future application of irradiation for preservation of some of these fruits are outlined. 128 references.

1986-01-01

65

Radiation accidents with multi-organ failure in the United States.

The patient positioning and repositioning control in radiation therapy all along the treatment can be conducted using a variety of X-ray sources and imaging detector devices. The development of image guided radiation therapy techniques leads to more frequent use of this imaging control. In this article we summarize the current methods for measuring the dose delivered by X-ray imaging devices used in radiation therapy, as well as basic proposals to take account of these imaging doses for prescribing, recording and reporting radiation therapy treatment. (authors)

2008-12-15

66

Organization of setting-up sanitary pass-control regime and sanitary treatment of injured persons in case of radiation accidents

Only a small number of radiation accidents in the United States have been severe enough to result in multi-organ failure (MOF). Medical details of selected medical misadministration and criticality cases are reviewed, with an emphasis on pathophysiology. The four criticality cases are particularly relevant for analysis of MOF, since medical treatment was supportive and did not appreciably alter the clinical evolution of radiation injury. PMID:15975871

2005-01-01

67

Pathways, Outcomes, and Costs in Colon Cancer: Retrospective Evaluations in Two Distinct Databases

The main aim of sanitary pass-control regime is to prevent propagation of radioactive contamination outside the area of emergency-rescue works and guarantee of sanitary treatment of all persons having radioactive contamination. The paper has studied the questions of organization of sanitary pass-control regime, arrangement of sanitary treatment of the injured persons and rendering first aid in case of radioactive contamination of wounds. 5 refs.

68

Memories of John N. Brady: scientist, mentor and friend

Purpose:The goal of this study was to use two separate databases to evaluate the clinical outcomes and the economic impact of adherence to Level I Pathways, an evidence-based oncology...Full Text Available

2011-05-01

69

Initial Report of the Cancer PROMIS Supplement Sexual Function Committee: Review of Sexual Function Measures and Domains Used in Oncology

Friends and colleagues remember John N. Brady, Ph.D., Chief of the Virus Tumor Biology Section of the Laboratory of Cellular Oncology, who died much too young at the age of 57 on April 27, 2009 of colon...Full Text Available

70

Decentralized Data Sharing of Tissue Microarrays for Investigative Research in Oncology

ObjectiveThis report describes initial activities of the Cancer Patient-Reported Outcomes Measurement Information System (PROMIS) Sexual Function domain group (CaPS-SF),...Full Text Available

2009-03-15

71

Advances in Fine Needle Aspiration Cytology for the Diagnosis of Pulmonary Carcinoma

Tissue microarray technology (TMA) is a relatively new approach for efficiently and economically assessing protein and gene expression across large ensembles of tissue specimens. Tissue microarray technology...Full Text Available

72

Radiotherapy and multimodality management of cholangiocarcinoma

New developments in the field of thoracic oncology have challenged the way pathologists approach the diagnosis of pulmonary carcinoma. Nonsmall cell carcinoma is no longer an adequate diagnostic category....Full Text Available

73

Combined chemotherapy and radiotherapy: from biology to bed-side

Purpose: To evaluate the results of radiotherapy in cholangiocarcinoma patients managed with various combinations of chemotherapy and surgical resection with selective liver transplantation. Methods and Materials: From January 1990 to December 1995, 61 patients with histologically confirmed biliary duct adenocarcinoma were seen in the Radiation Oncology Department of the University of Pittsburgh. Median follow-up was 22 months (1 to 91 months). The extent of surgery was complete resection in 23 patients (including 17 with orthotopic liver transplant), partial resection in 4, and biopsy in 34. All patients had radiotherapy; median dose was 49.5 Gy. Thirty patients received chemotherapy: 5-fluorouracil (5-FU)-leucovorin with interferon alpha (IFN#alpha#) in 27, and taxol in 3. Results: The median survival was 20 months (95% CI 15-25 months). The 5-year actuarial survival was 23.8 #+-# 6.8%. The only significant variable in multivariate analysis ...

1999-04-01

74

Radiation treatment for sterilization of packaging materials

Combination of radiotherapy and chemotherapy (CRC) is actually one important way of research in oncology. Theoretical advantages are: (1) Spatial cooperation; (2) Additivity, which is only obtained if the toxicity of each modality are different; (3) Supra-additivity, which needs a rigorous in vitro definition; the only way to prove it is to make an isobologram analysis. This model has however, some limitations: qualitative variable could not be used, results could be different, depending on the cell line and isoeffect chosen...In fact, a supra-additivity was only demonstrated for cis platinum and etoposide. Interactions mechanisms were: (1) at the molecular level, creation of new lesions or inhibition of radiation lesions repair; (2) At the cellular level, either cytokinetic cooperation with S-phase dependent drugs, or synchronization for the drugs which blocked the cells in M-phase; (3) At the tissular level, reoxygenation, cycle ...

75

Determination of gamma radiation dose as a post-harvest treatment in mangos infested with the South American fruit fly

Treatment with gamma and electron radiation is becoming a common process for the sterilization of packages, mostly made of natural or synthetic plastics, used in the aseptic processing of foods and pharmaceuticals. The effect of irradiation on these materials is crucial for packaging engineering to understand the effects of these new treatments. Packaging material may be irradiated either prior to or after filling. The irradiation prior to filling is usually chosen for dairy products, processed food, beverages, pharmaceutical, and medical device industries in the United States, Europe, and Canada. Radiation effects on packaging material properties still need further investigation. This paper summarizes the work done by different groups and discusses recent developments in regulations and testing procedures in the field of packaging technology.

2007-08-01

76

Radiation therapy in the treatment of hilar cholangiocarcinoma

Efforts are being made to determine a gamma radiation dose for mortality of third-instar larvae of Anastrepha fraterculus which infest mangos of the Haden variety of 400 g weight. Four radiation treatments were tested: 0.4 kGy, 0.6 kGy, 0.8 kGy and 1.0 kGy. Using as a criterium for mortality the interruption of the biological cycle between larva and pupa, the following results were achieved: 49.61%, 63.33%, 74.86% and 90.72%. The percentages obtained have been corrected using the Abbot formula. When the criterium was based on no adult emergence, 100% mortality was achieved for the four treatments. (author)

1999-01-01

77

Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine

The incidence of hilar cholangiocarcinoma is very rare worldwide. Radical resection is the only prognostic factor for long survival in patients with hilar cholangiocarcinoma. Postoperative radiation therapy can improve local control and survival rates for patients with palliative resection, but it remains controversial in patients with radical resection. Biliary drainage can effectively release bile duct obstruction for the majority of patients with locally advanced disease, and may even prolong survival when combined with radiation therapy. Radiation therapy includes extrernal beam therapy alone, external beam therapy with intraluminal brachytheapy and new radiation technique, such as three dimentional conformal therapy and intensity modulated radiation therapy. The propective randomized clinical study is needed for further investigation in the role of combined modality therapy ...

2007-10-01

78

Anatomical Description of the Female Reproductive Organ and Radiation Induced Histological changes of Ovary of Melon fly, Bactrocera cucurbitae (Coq.) (Diptera: Tephritidae)

This book examines the applications of Monte Carlo (MC) calculations in therapeutic nuclear medicine, from basic principles to computer implementations of software packages and their applications in radiation dosimetry and treatment planning. It is written for nuclear medicine physicists and physicians as well as radiation oncologists, and can serve as a supplementary text for medical imaging, radiation dosimetry and nuclear engineering graduate courses in science, medical and engineering faculties. With chapters is written by recognised authorities in that particular field, the book covers the entire range of MC applications in therapeutic medical and health physics, from its use in imaging prior to therapy to dose distribution modelling targeted radiotherapy. The contributions discuss the fundamental concepts of radiation dosimetry, radiobiological aspects of targeted radionuclide ...

2003-01-01

79

Packaging materials for use in radiation processing of foods

Application of gamma radiation as a physical method of disinfestations against melon flies was recognized as a potential quarantine treatment. At 50 Gy, oocytes showed degeneration one day after treatment whereas seven-day-old oocytes did not differ greatly in appearance from control groups. Abnormal enlargement of trophocyte cells and vacuolization of oocytes occurred predominantly following the treatment with 100 and 150 Gy. One day after treatment with 150 Gy trophocytes underwent hypertrophy and hyperplasia. Irradiation at 100 and 150 Gy reduced the fertility to almost zero percent in the female melon flies.(authors)

2006-06-01

80

Intraoperative and external beam irradiation for locally advanced colorectal cancer.

In radiation processing of food, the product often has to be prepackaged to prevent microbial recontamination during and after irradiation. The packaging material is exposed to radiation during radiation processing and radiation stability is a key consideration in the selection of packaging materials. The effects of ionizing radiation on many food packaging materials at the dose levels recommended for food precessing can be minimized by selecting appropriate radiation resistant materials. It is important to select materials in which chemicals formed as a result of the radiation treatment do not migrate and interact with the food, affecting its organoleptic and toxicological aspects. It is also important to select materials in which the physical properties are not altered to the extent they cannot resist damage during ...

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81

Intensity modulated radiotherapy: advantages, limitations and future developments

In view of poor local control rates obtained with standard treatment, intraoperative radiation (IORT) using electrons was combined with external beam irradiation and surgical resection, with or without...Full Text Available

1988-01-01

82

Excessive Soft Tissue Reaction after Stereotactic Body Radiation Therapy in a Woman with Four Different Cancer Diagnoses

Intensity modulated radiotherapy (IMRT) is widely used in clinical applications in developed countries, for the treatment of malignant and non-malignant diseases. This technique uses multiple radiation...Full Text Available

83

Bleeding during cancer treatment: MedlinePlus Medical Encyclopedia

Patients experiencing several cancers can be a challenge, as optimal treatment options for the different cancers might interfere with each other. In this case report, we present a woman diagnosed with...Full Text Available

84

Relationship of doxorubicin- and radiation-induced apoptosis with Ki-67 labeling index in human tumors in vivo

- flushing Chemotherapy - what to ask your doctor Dry Mouth Oral mucositis Peripherally inserted central catheter Radiation therapy - what to ask your doctor Safe drinking during...

2011-08-09

85

Applications or radiation polymerization hardening to composites

In the use of doxorubicin and radiation for treatment of human malignant tumors in vivo, the relationship between treatment-induced apoptosis and Ki-67 labeling index was investigated. Four human tumor xenografts (ependymoblastoma, NNE; primitive neuroectodermal tumor, YKP; small cell lung carcinoma, GLS; glioblastoma, KYG) were transplanted under the skin of thigh of the nude mice (BALB/cA JcL-nu). The mice were given a single radiation dose of 1 Gy, or doxorubicin alone intraperitoneally at a dose of 8 mg/kg. After treatment, sections of tumor specimens were prepared from paraffin-embedded tissues. Hematoxylin and eosin staining, TUNEL staining, and immunohistochemical analysis of Ki-67 were performed. In NNE, apoptotic cells appeared most frequently after treatment compared with all other tumors, and the incidence of apoptosis in the ...

1999-11-01

86

Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer

Comprehensive investigation has been made into the application of the polymerization hardening by radiation, particularly electron beam, to the composites of polymers and other materials. The report is divided into four parts, namely 1) characteristics and problems of the reaction of curing by radiation polymerization, 2) improvement of the bonding capability of high molecular weight materials, 3) bonding by radiation, and 4) composites made by the impregnation and polymerization hardening of monomers. The first part includes the effects of dose rate, temperature rise during the hardening, the peculiarity of electron beam irradiation at high dose rate, reaction environment and additive effects. Main conclusions are as follows: caution must be taken to the amount of residual double bonds because they affect the quality of hardened polymers; the polymerization hardening reaction at high dose rate cannot be analogized by that ...

1976-01-01

87

DEFF Research Database (Denmark)

Purpose Cisplatin plus gemcitabine is a standard regimen for first-line treatment of advanced non-small-cell lung cancer (NSCLC). Phase II studies of pemetrexed plus platinum compounds have also shown activity in this setting. Patients and Methods This noninferiority, phase III, randomized study compared the overall survival between treatment arms using a fixed margin method (hazard ratio [HR] < 1.176) in 1,725 chemotherapy-naive patients with stage IIIB or IV NSCLC and an Eastern Cooperative Oncology Group performance status of 0 to 1. Patients received cisplatin 75 mg/m(2) on day 1 and gemcitabine 1,250 mg/m(2) on days 1 and 8 (n = 863) or cisplatin 75 mg/m(2) and pemetrexed 500 mg/m(2) on day 1 (n = 862) every 3 weeks for up to six cycles. Results Overall survival for cisplatin/pemetrexed was noninferior to cisplatin/ gemcitabine (median survival, 10.3 v 10.3 months, respectively; HR = 0.94; 95% CI, 0.84 to 1.05). ...

2008-01-01

88

Health risks arising from ionizing radiation and chemical pollutants

The effect of irradiation on packaging materials

In quantifying health risks arising from radiation exposure and synergistic effects promoted by radiation the dose-effect relationship must be used as a basis. Special problems arise in the extrapolation of experimental results or in the treatment of data in the region of low doses administered over long periods of time. For radiation protection purposes, especially manifestations of cancer and genetic effects are significant. The International Commission on Radiation Protection has published binding guiding values on the basis of which to assess the risk of cancer. The cancer risk and genetic risks are estimated for relevant dose ranges and compared with other factors of civilization. For the most important chemical pollutants emitted into the environment the possibilities of impacts arising from synergistic effects are discussed on the basis of the rules and regulations specified ...

1979-10-03

89

Ionizing radiation, mainly in the form of #gamma#-rays from the radioisotope cobalt 60, is being used increasingly for the inactivation of contaminants in cosmetic and toiletry preparations. The treatment is applied to the product in its final pack, and therefore, it is important to recognize that the properties of the packaging materials could be affected, particularly if high radiation doses are used. The stability of a wide range of materials is discussed. The nature and extent of chemical and physical changes in plastics very much depends on the presence of antioxidants and other additives, and on the environmental conditions during irradiation. Some useful information is available from research into the use of radiation for the preservation of food - many films and laminates have been cleared for use in the United States. The low radiation doses used for the control of ...

90

Irradiation of food

Radiation treatment of some poultry products

Processing of food with ionizing radiation is a method suitable to enhance shelf-life and hygienic quality. Up to a dose of 10 kGy the method is considered wholesome. In many countries the practical use of food irradiation is increasing, however, in the Federal Republic of Germany the process is strictly forbidden. Applications and methods for radiation processing of food are compiled, limits and prospects are explained, and advantages and disadvantages are compared with traditional methods. Identification of irradiated foods and dosimetry and process control for radiation processing of food are areas where further research is needed. Continuous processing of particulate foods in bulk is an application where electron accelerators might be profitable. Beam parameters and velocity distribution of food particles in the treatment area can be matched for an effective result. Thus, dose distribution can be ...

91

Radiation treatment of crude drugs. Development of suitable methods of detection. Strahlenbehandlung von Arzneidrogen. Entwicklung geeigneter Nachweismethoden

Practical procedures were developed for large-scale microbial decontamination of dry egg powder and gelatine with gamma radiation ("6"0Co). The formation and lifes of free organic radicals in these materials were examined by ESR measurements of powder samples. The concentration of these radicals was studied in dependence on the time of storage. Secondary oxidation of egg fats by air oxygen was investigated. Sensoric tests of irradiated gelatine, both in powder and hydrogel form, were performed. (author). 4 figs., 2 tabs., 2 refs.

1988-09-26

92

Fractionation of combined heat and radiation in asynchronous CHO cells. II. The role of cell-cycle redistribution

It may be necessary to reduce microbiological contamination of crude drugs (medicinal plants or their parts like roots, leaves, flowers). This can be done by treating the drugs with ionizing radiation. Meethods for detection of such an irradiation were developed. It could be pointed out that measurements of luminescence, viscosity and electron spin resonance were suitable for specific drugs, but not for all drugs. (orig.).

1992-09-01

93

The value of radiotherapy in the treatment of Ewing's sarcoma in children

Asynchronous Chinese hamster ovary (CHO) cells treated with conditioning hyperthermia (10 min at 45/sup 0/C) followed immediately by x irradiation with 4 Gy at room temperature display a decreased radiation response when either irradiated, or heated and irradiated again 24 h later. In addition, conditioning by 4 Gy of x radiation alone followed at 24 h by the combined heat and radiation treatment als resulted in a larger radiation D/sub 0/. Since the differential cell-cycle responses to heat- and x-ray-induced lethality are well established for CHO cells, the potential role of cell-cycle redistribution in the observed radiation desensitization was investigated by flow cytometry. At 24 h after the combined treatment, the fraction of the cells found in the G/sub 2/ + M portion of the DNA histograms was about three times that of the controls ...

1979-11-01

94

Radionuclide X-ray fluorescence determination of Mn, Fe, Cu, Zn and Pb in wastewaters and sludges from wastewater treatment plants in Bratislava (SR)

Results of treatment of 30 children with Ewing's sarcoma irradiated in the First Radiotherapy Department, Cancer Center, Warsaw, in the period 1983-1992, are described. In 40% of patients NED survival from 1 till 10 years and in 70% the local control was obtained, and no serious radiations equelae were observed. (author).

95

Radiation inactivation target size of rat adipocyte glucose transporters in the plasma membrane and intracellular pools

Radiometric X-ray fluorescence analysis was used for the determination of Mn, Fe, Cu, Zn and Pb in wastewater and sludges from three wastewater treatment plants in Bratislava (SR). Metals were determined in wastewaters after preconcentration by 8-hydroxyquinoline and in sludges by drying and pressing to pellets. "2"3"8Pu and "1"0"9Cd was used for excitation of fluorescence radiation. (author).

1997-01-01

96

Radiation decontamination of dry food ingredients and processing aids

The in situ assembly states of the glucose transport carrier protein in the plasma membrane and in the intracellular (microsomal) storage pool of rat adipocytes were assessed by studying radiation-induced inactivation of the D-glucose-sensitive cytochalasin B binding activities. High energy radiation inactivated the glucose-sensitive cytochalasin B binding of each of these membrane preparations by reducing the total number of the binding sites without affecting the dissociation constant. The reduction in total number of binding sites was analyzed as a function of radiation dose based on target theory, from which a radiation-sensitive mass (target size) was calculated. When the plasma membranes of insulin-treated adipocytes were used, a target size of approximately 58,000 daltons was obtained. For adipocyte microsomal membranes, we obtained target sizes of approximately 112,000 and 109,000 daltons prior ...

1987-06-15

97

The role of brachytherapy in radiation and isotopes centre of Khartoum (RICK)

Radiation decontamination of dry ingredients, herbs and enzyme preparations is a technically feasible, economically viable and safe physical process. The procedure is direct, simple, requires no additives and is highly efficient. Its dose requirement is moderate. Radiation doses of 3-10 kGy (0.3-1 mrad) have proved sufficient to reduce the viable counts to a satisfactory level. Ionising radiations do not cause any significant rise in temperature. The flavour, texture or other important technological or sensory properties of most ingredients are not influenced at radiation doses necessary for satisfactory decontamination, and radiation obviates the chemical residue problem. The microflora surviving radiation decontamination of dry ingredients are more susceptible to subsequent antimicrobial treatments. Recontamination can be prevented as the ...

98

The application of Geant4 simulation code for brachytherapy treatment

As there are many efforts devoted in order to manage the cancer, here the researcher handle one of these efforts that play a major part in treating the cancer internationally, it is a brachytherapy system. Brachytherapy was carried out mostly with radium sources, but recently some artificial sources are incorporated in this mode of treatment such as Cs-137, Ir-192, Au-198, P-32, Sr-90 and I-125. The research cover history of brachytherapy and radioactive sources used in, techniques of implementation, radiation protection and methods of brachytherapy dose calculation, as well as brachytherapy in radiation and isotopes centre in Khartoum.

99

Review of electron beam therapy physics

Brachytherapy is a radiotherapeutic modality that makes use of radionuclides to deliver a high radiation dose to a well-defined volume while sparing surrounding healthy structures. At the National Institute for Cancer Research of Genova a High Dose Rate remote afterloading system provides Ir(192) endocavitary brachytherapy treatments. We studied the possibility to use the Geant4 Monte Carlo simulation toolkit in brachytherapy for calculation of complex physical parameters, not directly available by experiment al measurements, used in treatment planning dose deposition models.

2000-01-01

100

Ewing's sarcoma: treatment and prognosis

For over 50 years, electron beams have been an important modality for providing an accurate dose of radiation to superficial cancers and disease and for limiting the dose to underlying normal tissues and structures. This review looks at many of the important contributions of physics and dosimetry to the development and utilization of electron beam therapy, including electron treatment machines, dose specification and calibration, dose measurement, electron transport calculations, treatment and treatment-planning tools, and clinical utilization, including special procedures. Also, future changes in the practice of electron therapy resulting from challenges to its utilization and from potential future technology are discussed. (review)

2006-07-07

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101

Radiotherapy for nonfunctioning pituitary adenomas: from conventional to modern stereotactic radiation techniques

The results of treatment of 134 cases of morphologically-verified localized Ewing's sarcoma were evaluated. A comparative analysis showed relapse-free survival to be significantly lower for radiation treatment (23 %) than for its combination with various cytostatic drugs. Two-year relapse-free survival rate was as high as 43 % in cases receiving sarcolysin or cyclophosphamide as adjuvants. This was matched by 47 % for adjuvant ardiamycin or carminomycin and 56 % for adriamycin plus cyclophosphamide and vincristine. Evaluation of long-term results of adjuvant chemotherapy showed sex, age and site involvement to be of certain prognostic value.

102

British Library Electronic Table of Contents (United Kingdom)

The initial management of nonfunctioning pituitary macroadenomas (NFAs) is usually surgery; however, a significant proportion of NFAs may require further treatment. Radiotherapy is currently used in patients with residual tumour and achieves excellent long-term control, but there are concerns about potential late toxicity. Stereotactic radiotherapy, both in the form of radiosurgery or fractionated stereotactic radiotherapy, has been developed as a more accurate technique of irradiation with more precise tumour localization and consequently a reduction in the volume of normal tissue, particularly the brain, irradiated to high radiation doses. A review of the literature suggests that new radiation techniques offer safe and effective treatment for recurrent or residual pituitary adenomas; how...

2007-01-01

103

Intensity-Modulated Radiation Therapy with Noncoplanar Beams for Treatment of Prostate Cancer in Patients with Bilateral Hip Prosthesis-A Case Study

Ewing's sarcoma. Radiographic pattern of healing and bony complications in patients with long-term survival

Megavoltage photon intensity-modulated radiation therapy (IMRT) is typically used in the treatment of prostate cancer at our institution. Approximately 1% to 2% of patients with prostate cancer have hip prostheses. The presence of the prosthesis usually complicates the planning process because of dose perturbation around the prosthesis, radiation attenuation through the prosthesis, and the introduction of computed tomography artifacts in the planning volume. In addition, hip prostheses are typically made of materials of high atomic number, which add uncertainty to the dosimetry of the prostate and critical organs in the planning volume. When the prosthesis is bilateral, treatment planning is further complicated because only a limited number of beam angles can be used to avoid the prostheses. In this case study, we will report the observed advantages of using noncoplanar beams in the delivery of IMRT to ...

2010-01-01

104

Radiation hardening of final optics for an ICF reactor

The radiographic appearance of Ewing's sarcoma was studied retrospectively in 22 patients who survived 5 years or longer after diagnosis and treatment. Expected changes from treatment, including regression of the extraosseous soft tissue mass, periostitis, and reconstitution of the cortex, occurred in all patients. Local recurrence occurred in one patient 10 years after complete remission whereas secondary osteosarcoma occurred more than 5 years after complete remission in two other cases. Both recurrent and secondary tumors presented as new lytic foci at the site of the original primary lesion. Lytic changes from radiation (radiation osteitis) may develop more than 2 years after treatment and in this sample; such findings were widely distributed in the radiation port. The authors conclude that bone remodeling and postradiation changes occur slowly over 2 years ...

105

Effectiveness of radiation therapy after surgery for hilar cholangiocarcinoma

Radiation damage of the final optical components in an Inertial Confinement Fusion (ICF) reactor is a crucial issue for development of a laser-fusion reactor. To some extent, this problem will be encountered in the National Ignition Facility (NIF), but there, the integrated radiation dose will be considerably less than that encountered in a future reactor. This extremely harsh radiation environment necessitates shielding the ICF optics from direct neutron and x-ray bombardment. Several approaches have been suggested, such as the use of grazing incidence metal mirrors or fused silica wedge deflectors. While metal mirrors can withstand a larger radiation dose, their focusing qualities pose problems. Therefore wedge deflectors, originally suggested by Lawrence Livermore National Laboratory (LLNL) staff, represent a promising alternative. Radiation hardening of the fused silica ...

1995-04-24

106

Non-seminomatous testicular germ cell tumours in Denmark 1976-1980. Results of treatment

Some studies suggest that giving radiation therapy after surgery for hilar cholangiocarcinoma improves the survival rate; however, many of these studies did not specify numbers of subjects or provide an impartial analysis. Thus, we evaluated the effectiveness of radiation therapy as adjuvant treatment after surgery and attempted to establish appropriate adaptation standards. We reviewed the records of 69 patients who underwent surgery for hilar cholangiocarcinoma between June 1980 and April 1998. Thirty-nine patients were treated with surgery followed by radiation therapy and 30 were treated with surgery alone. The clinicopathologic features that might have influenced prognosis were similar in the patients who received radiation therapy and those who did not. Radiation as adjuvant therapy did not have a beneficial effect on overall survival (P=0.554, log-rank ...

2005-07-01

107

Exploring the mechanism of radiation-enhanced hepatocellular carcinoma cell invasion by swept source optical coherence tomography

Over a 5-year period (1976-1980) 499 patients with non-seminomatous testicular germ cell tumours were included in the Danish Testicular Carcinoma Study (DATECA). The 3-year crude survival for patients in clinical stages I, II and III was 91, 77 and 45 per cent, respectively. In stage I the relapse-free survival for patients given radiation combined with bleomycin and vincristine was significantly higher than that for patients given radiation alone. No difference in the crude survival for patients given radiation combined with bleomycin and vincristine was significantly higher than that for patients given radiation alone. No difference in the crude survival was observed. For stage II patients maintenance chemotherapy following radiation combined with bleomycin and vincristine did not improve relapse-free or crude survival. The survival of patients with non-seminomatous tumours ...

1984-01-01

108

Effective radiation therapy on two cases of primary Ewing's sarcoma of the rib

Ionizing radiation is a standard treatment for various human solid tumors. However, several clinical studies showed that a significant proportion of patients undergoing radiotherapy for hepatocellular carcinoma (HCC) develop intrahepatic and extrahepatic metastasis. Understanding of radiation-induced cancer cell invasiveness and behavior is essential and of great important for developing suitable treatment strategies to contain cancer spread. Therefore, in this study we evaluated the effectiveness of using swept source optical coherence tomography (SS-OCT) to monitor the enhancement of HCC cell invasiveness by radiation. SS-OCT images were acquired and recorded to obtain three-dimensional data sets per four hours in 48 hours after irradiating HepG2 cells with 7.5 Gy. The cell migration behavior in three-dimensional tissue models was quantified from images of ...

2011-02-01

109

Paediatric radiography - the avoidance of late radiation damage to the growing hip

Two cases of primary Ewing's sarcoma of the rib are reported, in which radiation therapy was quite effective. Case 1 was an 18-year-old female who had had an operation and radiation therapy for Ewing's sarcoma of the left 7th rib. She was referred to our hospital after a recurrent tumor was found. Radiation therapy (tumor dose 46.2 Gy) and chemotherapy were given. The tumor disappeared and there has been no relapse for 1 year and 3 months after the treatment. Case 2 was a 2-year-old-infant. Radiation therapy (tumor dose 74 Gy) was given for primary Ewing's sarcoma of the left 6th rib. The tumor became small and was successfully removed at operation. There has been no relapse or distant metastasis for 8 months following the operation. We emphasize the importance of multidisciplinary treatment in case 1 and the usefulness of preoperative radiotherapy in case 2. ...

110

New procedures. Comprehensive staging of lung cancer by MRI

Epiphyseal plates of growing bones are sensitive to ionizing radiation and this poses problems for the paediatric radiotherapist. In this case report we describe a child in whom electron beam therapy to the groin delivered only low dose radiation to the proximal hip epiphyses - 130 cGy fractionated over 5 weeks - but who suffered late maldevelopment. We explore the success of various radiotherapy techniques in minimizing the dose to the hip epiphyses in four other children. The appropriate positioning of the limb, the choice of treatment modality and, where possible, individual shielding blocks are considered and their effect on the dose to the hip estimated. Absorbed doses of radiation delivered to the midpoint of the proximal femoral epiphyses have been retrospectively determined. (author).

1993-04-01

111

Functional and Oncologic Outcomes of Partial Adrenalectomy for Pheochromocytoma in Patients With von Hippel-Lindau Syndrome After at Least 5 Years of Followup

Lung cancer staging according to the TNM system is based on morphological assessment of the primary cancer, lymph nodes and metastases. All aspects of this important oncological classification are measurable with MRI. Pulmonary nodules can be detected at the clinically relevant size of 4-5 mm in diameter. The extent of mediastinal, hilar and supraclavicular lymph node affection can be assessed at the same time. The predominant metastatic spread to the adrenal glands and spine can be detected in coronal orientation during dedicated MRI of the lungs. Search focused whole body MRI completes the staging. Various additional MR imaging techniques provide further functional and clinically relevant information during a single examination. In the oncological context the most important techniques are imaging of perfusion and tumor motion. Functional MRI of the lungs complements the pure staging and improves surgical approaches and radiotherapy planning. ...

2010-08-01

112

British Library Electronic Table of Contents (United Kingdom)

PurposeAlthough the safety and feasibility of partial adrenalectomy in patients with von Hippel-Lindau syndrome have been established, long-term outcomes have not been examined. In this study we evaluate the recurrence and functional outcomes in a von Hippel-Lindau syndrome cohort treated for pheochromocytoma with partial adrenalectomy with a followup of at least 5 years. Materials and MethodsWe reviewed the records of patients with von Hippel-Lindau syndrome treated with partial adrenalectomy for pheochromocytoma at the National Cancer Institute. Demographic, germline mutation status, surgical indication, oncologic and functional outcome data were collected. Local recurrence was defined as radiographic evidence of recurrent tumor on the ipsilateral side of partial adrenalectomy. Patients ...

2010-01-01

113

Correlation between tensile property and micro-hardness in reduced activation ferritic/martensitic steel irradiated at 573 K

The use of "1"3"1I-radioiodine in diagnostic and treatment: estimated risk in Guanabara

Full text of publication follows: Radiation hardening and embrittlement due to high-energy neutron radiation around 623 K are the important issues on reduced-activation ferritic/martensitic (RAF/M) steels. It is expected that the improvement of radiation hardening might be one of effective ways to control the mechanical properties of RAF/M after irradiation. It has been reported that the weld joint has less hardening than the base metal from the tensile test results of TIG weldments irradiated in HFIR. This report indicated that radiation hardening can be reduced by the optimization of heat treatment condition for F82H. The purposes of this study are to establish the condition of heat treatment for minimum of radiation hardening in F82H steel using Neutron/Ion-irradiation and to examine a correlation between tensile property and ...

2007-12-10

114

Effect of irradiation on bone remodelling and the structural integrity of the vertebral column. Doctoral thesis

The "1"3"1-radioiodine use in Guanabara area, during 1972-1973, is analysed. References are made to the radiation levels delivered to thyroid, bone marrow and gonads in a population of 27000 people examined by tracer techniques, 190 submitted to hyperthyroidism treatment and 50 treated for thyroid cancer. The pertinent literature gives some data concerning radiation induced cancer (leukaemia and thyroid cancer). By this, it was possible to estimate the probability of tumour occurrence in that population, assuming a linear relationship between dose and effect. The conclusions are the followings: 1 - there are many duties in this field at the present; 2 - the leukaemia incidence related to the 131-radioiodine use is negligible, either in diagnostic or therapeutic modalities; 3 - the possibility of thyroid tumors induced by radiation is real, specially in hyperthyroidism treatment; 4 - ...

115

Bevacizumab as a treatment option for radiation-induced cerebral necrosis

The effects of therapeutic levels of radiation on the axial properties of the primate vertebral column were studied. Seven male rhesus monkeys (Macaca mulatta) were irradiated with a single does of 1300 cGy to the specific lumbar vertebrae of L2, L3, and L4. Three additional animals served as controls. Radiographs were taken before the radiation treatment and just prior to sacrifice to determine density changes in the bone. The animal subjects were sacrificed 105 days following the radiation exposure. Biomechanical testing was completed on lumbar levels 2 and 3 to identify changes in strength characteristics following radiation treatment. Histomorphometric analysis of lumbar vertebrae level 4 was completed to identify volume and surface density changes as well as cellular changes. Tetracycline, dicarbomethylaminomethyl fluorescein (DCAF), and xylenol orange were ...

1990-01-01

116

Luminescence characteristics for the detection of radiation treatment of shellfish by using isolated minerals

Radiation necrosis of normal CNS tissue represents one of the main risk factors of brain irradiation, occurring more frequently and earlier at higher total doses and higher doses per fraction. At present, it is believed that the necrosis results due to increasing capillary permeability caused by cytokine release leading to extracellular edema. This process is sustained by endothelial dysfunction, tissue hypoxia, and subsequent necrosis. Consequently, blocking the vascular endothelial growth factor (VEGF) at an early stage could be an option to reduce the development of radiation necrosis by decreasing the vascular permeability. This might help to reverse the pathological mechanisms, improve the symptoms and prevent further progression. A patient with radiation-induced necrosis was treated with an anti-VEGF antibody (bevacizumab), in whom neurologic signs and symptoms improved in accordance with a decrease in T1-weighted ...

2011-02-01

117

A comparison study for dose calculation in radiation therapy: pencil beam Kernel based vs. Monte Carlo simulation vs. measurements

Seven types of shellfish were irradiated by gamma ray at doses of 0, 3 and 6 kGy. Pulse photo-stimulated luminescence (PPSL) and thermoluminescence (TL) methods were employed to detect the radiation treatment. The screening of irradiation was carried out by the PPSL method followed by identification using the TL technique. Most of the irradiated shellfish were screened out correctly and only a few showed photon counts a bit higher than the lower threshold value by much lower than the upper threshold value. The TL method was employed using minerals isolated from all the control and irradiated shellfish samples by density gradient treatment. Three parameters, integrated intensities of first glow curves (TL1), ratios of first to that of second glow curves (TL1/TL2), and the shapes of maxima of first glow curves, were utilized for the identification of gamma ray treatment of shellfish. (author)

118

Positive effects of UV radiation on a calanoid copepod in a transparent lake: do competition, predation or food availability play a role?

Accurate dose calculation in radiation treatment planning is most important for successful treatment. Since human body is composed of various materials and not an ideal shape, it is not easy to calculate the accurate effective dose in the patients. Many methods have been proposed to solve inhomogeneity and surface contour problems. Monte Carlo simulations are regarded as the most accurate method, but it is not appropriate for routine planning because it takes so much time. Pencil beam kernel based convolution/superposition methods were also proposed to correct those effects. Nowadays, many commercial treatment planning systems have adopted this algorithm as a dose calculation engine. The purpose of this study is to verify the accuracy of the dose calculated from pencil beam kernel based treatment planning system comparing to Monte Carlo simulations and measurements especially in ...

2002-10-20

119

British Library Electronic Table of Contents (United Kingdom)

Zooplankton tolerant to ultraviolet radiation (UVR) could be indirectly affected by UVR through interactions with UV-sensitive species in the same ecosystem. In Lake Giles, Pennsylvania, USA, the calanoid copepod Leptodiaptomus minutus is more UVR tolerant than the cohabiting species Daphnia catawba and Cyclops scutifer. We asked whether L. minutus is affected by UV-induced mortality of a food competitor (D. catawba) or a predator of its nauplii (C. scutifer). We conducted two in situ enclosure experiments with six treatments: L. minutus alone, L . minutus + Daphnia and L. minutus + Cyclops in the presence and absence of UVR. There were few differences in survival among treatments in Experiment 1, which had enhanced food and a cumulative UVR (320 nm) dose of 9.3 kJ m-2. In Experiment 2, wh...

2006-01-01

120

Effects of acute and chronic gamma irradiation on the shoot apex and general morphology of Lupinus albus L

Dosimetric evaluation of multi-pattern spatially fractionated radiation therapy using a multi-leaf collimator and collapsed cone convolution superposition dose calculation algorithm

Lupinus albus L. plants were grown from seeds and irradiated at various stages of development with acute or chronic gamma rays. All plants were greenhouse grown (pre- and post-irradiation) and allowed to proceed through their normal growth cycle. The purpose of these experiments was to establish a Plactochron Index for Lupinus albus L. and to determine the effects of acute and chronic irradiation on development at the macro and microscopic levels. A Plastochron Index was calculated and used as an indirect time scale to evaluate the effects of gamma rays from a common base line. Acute radiation treatment lasted for a period of a few days, whereas chronic treatment was initiated at the seedling stage and lasted for the entire growth season. Vegetative plants were used to study the effects of acute radiation exposure on apical meristem morphology, Plastochron Index, phyllatoxis and gross morphology.

1980-01-01

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121

British Library Electronic Table of Contents (United Kingdom)

Purpose: In this paper, we present an alternative to the originally proposed technique for the delivery of spatially fractionated radiation therapy (GRID) using multi-leaf collimator (MLC) shaped fields. We employ the MLC to deliver various pattern GRID treatments to large solid tumors and dosimetrically characterize the GRID fields. Methods and materials: The GRID fields were created with different open to blocked area ratios and with variable separation between the openings using a MLC. GRID designs were introduced into the Pinnacle3 treatment planning system, and the dose was calculated in a water phantom. Ionization chamber and film measurements using both Kodak EDR2 and Gafchromic EBT film were performed in a SolidWater phantom to determine the relative output of each GRID design as w...

2009-01-01

122

Ionising radiation effects on food packaging

Resonance scattering of Lyman-. cap alpha. radiation by hydrogen in the ground state

The main aim of any food irradiation treatment is to guarantee the best safe quality of the products, reducing the spreading risk ("cross-contamination") for several food-associated diseases. Actually, over 40 countries provide clearances for the treatment of about 45 different types of foodstuffs. EU has to homogenise the situation within the associated States. With the European directive 1999/2/EC Italy, as other EU countries, already has brought into force their regulations to comply. The current Italian regulation on irradiation treatment of foodstuffs is referred since 1996 as follows: a) potatoes, onions and garlic; b) spices, herbs and condiments microbial. The new (April 2001) Italian law allows the possibility to ask for special permission of treatment for other foodstuff which is possible to treat in other E.U. countries. Large majority of foods are submitted to irradiation ...

2001-10-22

123

Quantum electrodynamic and semiclassical interference effects in spontaneous radiation

We calculate the cross section for the resonance scattering of Lyman-..cap alpha.. radiation by spinless nonrelativistic hydrogen atoms in the ground state using a two-level model. A generalization of Dirac's resonance scattering theory is used together with the exact matrix elements for the electromagnetic interaction. In contrast to the usual treatments in which only the dipole approximation for the matrix elements are taken, the shift in position of the resonance is finite and has a value of 75% of the Lamb shift of the n=1 state. Whether this latter fact is significant in renormalization calculations is left open.

1980-11-01

124

Oncogenic transformation produced by agents and modalities used in cancer therapy and its modulation

The theory of spontaneous decay is studied using both quantum electrodynamics (QED) and semiclassical theories of radiation. There are qualitative differences between the theories in the prediction of interference phenomena. In QED, systems which were excited with pulsed laser light do not exhibit quantum interference effects associated with lower state splittings. On the other hand, semiclassical treatments of spontaneous decay do indicate the existence of interference effects not present in QED. In addition to this, differences are found between the predictions of fluorescence intensity in the presence of lower-state level crossings under continuous excitation. (U.S.).

1975-01-01

125

A mathematical model for simulating shallow solar ponds for treatment of industrial wastewater

The long-term survival of certain patients after treatment with radiation or chemotherapeutic agents has allowed the realization that agents that effectively control cancer in the human subject may also possess an oncogenic potential, resulting in secondary malignancies in a significant proportion of surviving patients. A quantitative assessment of the oncogenic effects of these agents at a cellular level is important, as is information on conditions and agents that may effectively alter the development of the neoplastic state. Cell culture systems where the neoplastic transformation of cells can be scored after exposure to carcinogens offer powerful tools for evaluating the oncogenic potential of radiation and chemotherapeutic agents.

1982-01-01

126

Radiotherapeutic methods for Ewing's sarcoma of the long tubular bones in children

This paper presents a mathematical model to analyze the solar evaporation in a shallow pond in steady state, when the inlet flow rate, concentration, surface area and solar radiation are given. The simultaneous heat and mass transfer mechanisms are considered for quantifying the amount of evaporated water to the atmosphere and the actual absorbed heat by wastewater is calculated to obtain the bottom temperature of water pond. The heat losses to air by radiation and convection mechanisms are considered and the heat transmission across the water film is evaluated by the forced convection mechanism. 6 refs., 5 figs., 1 tab.

1996-12-31

127

Mathematical child phantom for the calculation of dose to the organs at risk

Radiotherapeutic results of the Ewing sarcoma of the long tubular bones in 140 pediatric patients aged 3-16 are analyzed with the respect to different methods of irradiation. Three-field irradiation, the fields being located at 120 deg to one another with daily irradiation of all three fields at a focal dose of 2 Gy, was found superior in treatment of primary neoplasm. It is stressed that the disease termination mainly depends on the efficiency of primary neoplasm treatment, as the neoplasm reccurence generally is followed by metastases. Radiation load is calculated for maximal irradiation area of soft tissues in children.

128

Linac based free-electron laser

In order to calculate the doses received by the organs of 530 children treated by radiation for cancer between 1945 and 1969 at the G. Roussy Institute, we have developed a computer program for organ location calculation. To calculate the location of each child's organs of interest at the time of the treatment, only two parameters are necessary; sex and height or sex and age when the height at the time of the treatment is unknown. The algorithm is based on the metric studies of growth known as auxology. Each organ is located by one point representing its center. The model has been checked on 100 healthy children.

1988-05-01

129

Title of paper: the induction of P-53 independent programmed cell death (apoptosis) with ionizing radiation and 5-fluorouracil (5-FU) in the HT-29 human colon carcinoma cell line

A basic treatment of the principle of the linac-driven free-electron laser (FEL) is given. The first part of the paper describes the FEL in low-gain approximation, and in the second part the high-gain FEL theory is given. The majority of the treatment describes FELs in one dimensional approximation, neglecting effects by diffraction of radiation and by electron beam emittance. Only in the final section a few remarks on these issues are given. The ambition of the paper is by no means any progress in FEL theory but a clear presentation of basic FEL theory concepts with explicit derivation of the formulae from first principles. (orig.)

130

The EnviroLink Network - RTK Net

Purpose/Objective: The role of programmed cell death (apoptosis) as a cellular response to cancer therapy such as radiation or chemotherapy is the subject of much study, and manipulation of the apoptotic response in tumor cells may be valuable in the treatment of a variety of cancers. Both p53 dependent and independent apoptotic pathways have been identified; p53 is mutated in at least 50 % of human cancers and a majority of radiation resistant tumors contain p53 mutations. This study is designed to examine the induction of programmed cell death in a human colon carcinoma cell line that possesses two mutated p53 alleles. Ionizing radiation alone, or in combination with the chemotherapeutic drug 5-fluorouracil (5-FU), were used to elicit the apoptotic response. This study will focus on whether these treatments can induce a significant apoptotic response in cells that have mutated p53 ...

1996-09-01

131

Application of radiation in Bangladesh

... (last modified: 10/22/2002) Organizations Saratoga Foundation (last modified: 02/11/2003) Actions You Can Take Global Response (last modified: 05/10/2000) Organizations University of Pittsburgh Cancer Institute - Center for Environmental Oncology (last modified: 01/14/2005) Home | Site Map | About EnviroLink | Advanced Search | Suggest ...

132

Radiation treatment of medical devices and packaging materials. Pt. 1

Radiation technology offers a very wide scope for utilisation and commercial exploitation in various field. All over the world, this technology is being favourably considered for different applications like radiation sterilisation of medical products, preservation of food by controlling the physiological processes for extending shelf-life and eradication of microbial and insect pests, radiation processing of polymeric materials and treatment of sewage sludge. Bangladesh Atomic Energy Commission has taken radiation processing programmes in a big way right from its inception. This paper describes the studies carried out by various research groups in Bangladesh Atomic Energy Commission mainly using Cobalt-60 gamma radiation. The investigation covers medical sterilisation, food preservation and development and modification of polymeric materials by gamma ...

2001-03-01

133

Fifteen-year follow-up of a patient with beta thalassaemia and extramedullary haematopoietic tissue compressing the spinal cord

The first part of the study contains a literature compilation of more than 50 original publications reporting the radiation induced effects in 17 different high polymer materials and glass which are relevant in the manufacturing of medical devices or packing materials. The results collected demonstrate that high energy radiation, i.e. gamma- or X-rays, causes various physical and chemical alterations in high polymer materials. A detailed summary and discussion of the results of the original publications is not included in the present report, it will be presented in the second part of the study. Furthermore, the second part of the study will refer to the aspect of wholesomeness of irradiated medical devices or packing materials in a more general manner of representation. (orig.).

134

The BCNT treatment planning for the Brookhaven trials on human gliomas

A long-term follow-up of a patient with beta thalassaemia with intra- and extraspinal extramedullary haematopoietic tissue compressing the spinal cord is presented. Extramedullary haematopoietic nodules are a rare cause of spinal cord compression and should be included in the differential diagnosis, especially in patients from Mediterranean countries. Treatment with radiation therapy solely failed, giving rise to the need of surgical intervention. Surgical decompression of the spine and the removal of the culprit lesion compressing the spine were performed. Postinterventional radiation therapy was applied to the spine. A relapse had to be treated again by surgical means combined with postinterventional radiation therapy. A complete relief of the symptoms and control of the lesion could be obtained.

2005-04-01

135

Improvement on Liquid Radioactive Waste Treatment System of Nuclear Power Plant By Applying Ion Exchange Method

Boron neutron capture therapy (BNCT) trials for human glioma (glioblastoma multiform) were initiated September 1994 at the Brookhaven National Laboratory (BNL). Patients are given p-boronophenylalanine-fructose (BPA-F) intravenously as the boron carrier followed by exposure to the epithermal-neutron beam at the Brookhaven Medical Research Reactor (BMRR). The initial phase of the study is to determine safety and toxicity of the drug and irradiation procedure. The epithermal-neutron beam was developed in a joint effort by BNL and Idaho National Engineering Laboratory (INEL) researchers. For the human trials, treatment planning and radiation dose estimation is performed using the BNCT-Rtpe and the rtt-MC computer codes developed by the INEL BNCT program. This paper discusses our initial experience using these treatment planning codes for human subjects. The basic principles of BNCT have been previously documented.

136

Sphincter-saving procedure for radiation-injuried rectum. A report of four cases with special reference to pull-through procedure

Liquid radioactive waste treatment method of using evaporator was widely used from Kori 1 to Uljin 3 and 4, but a liquid radioactive waste treatment equipment that uses an ion exchange method instead of an evaporator was adopted aiming to minimize amount of radioactive waste and radiation exposure. However, the same equipment was introduced and applied for the first time in Korea and had experienced difficulties in securing credibility for the equipment and handling of liquid radioactive waste with inadequate data about performance and experience in operation and maintenance. In this study, examination, application and effect analysis was performed on the optimization measure for handling liquid radioactive waste of Yonggwang Nuclear Power Unit 5 and 6(YGN 5 and 6) that applies an ion exchange method

2010-10-01

137

Non-seminomatous testicular germ cell tumours in Denmark 1976-1980

Up to this time the sigmoid colostomy has been widely accepted and conventional treatment for radiation-injured rectum, but patients without residual malignancy strongly desire to live without colostomy. We have tried to remove the involved rectal segments by sphincter-saving procedures. Four patients underwent these procedures, pull-through procedure in three and low anterior resection in one. Among sphincter-saving procedures, pull-through procedure was most adequate. Provided the following five conditions are fulfilled, pull-through procedure should be considered for severe radiation-injured rectum. (1) No recurrence of initial malignancy in the pelvis. (2) More than 2 cm intact rectal segment above dentate line may be preserved. (3) No radiation-injured segment in upper sigmoid. (4) No severe radiation damage in small intestine. (5) Patients under 70 year-old, with normal tonus ...

1982-09-01

138

Total dose hardening of SIMOX buried oxides for fully depleted devices in rad-tolerant applications

Over a 5-year period (1976-1980) 499 patients with non-seminomatous testicular germ cell tumours were included in the Danish Testicular Carcinoma Study (DATECA). The 3-year crude survival for patients in clinical stages I, II and III was 91, 77 and 45 per cent, respectively. In stage I the relapse-free survival for patients given radiation combined with bleomycin and vincristine was significantly higher than that for patients given radiation alone. No difference in the crude survival for patients given radiation combined with bleomycin and vincristine was significantly higher than that for patients given radiation alone. No difference in the crude survival was observed. For stage II patients maintenance chemotherapy following radiation combined with bleomycin and vincristine did not improve relapse-free or crude survival. The survival of patients with non-seminomatous tumours ...

1976-01-01

139

Radiotherapy in Ewing's sarcoma and PNET of the chest wall: results of the trials CESS 81, CESS 86 and EICESS 92

A total dose hardening treatment is applied to SIMOX buried oxides. Total ionizing dose radiation testing is performed on fully-depleted transistors fabricated on both hardened and non-hardened substrates. At 200 krads x-ray dose, the front gate shift is reduced from -0.7 to -0.2 V for FETs built on the hardened wafers.

1996-07-15

140

M 1 decay rates of heavy quarkonia with a nonsingular potential

Purpose: Treatment results and the pattern of relapse were evaluated in the multimodal treatment of Ewing's sarcomas of the chest wall. Methods and Materials: In a retrospective analysis, 114 patients with non-metastatic Ewing's sarcoma of the chest wall were evaluated. They were treated in the CESS 81, CESS 86, or EICESS 92 studies between January 1981 and December 1993. The treatment consisted of polychemotherapy (VACA, VAIA, or EVAIA) and local therapy, either surgery alone (14 patients), radiotherapy alone (28 patients) or a combination of both (71 patients). The median follow-up was 46.6 months (range 5-170). A relapse analysis for all patients with local or combined relapses was performed. Results: Overall survival was 60% after 5 years, event-free survival was 50%. Thirty-seven patients had a systemic relapse (32.4%), 11 patients had a local relapse alone (9.6%), and 3 patients had a combined local and systemic ...

1998-12-01

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141

In vivo^99mTc-HYNIC-annexin V imaging of early tumor apoptosis in mice after single dose irradiation

We use a nonsingular-potential model for heavy quarkonia proposed by Gupta, Repko, and Suchyta to calculate the transition amplitudes for the magnetic-dipole ({ital M}1) one-photon radiative decays of the {ital c{bar c}} and {ital b{bar b}} bound systems. The wave functions of the bound systems are calculated by a nonperturbative treatment. The results are in better agreement with the experimental data than those predicted using other potential models.

1991-09-01

142

Dosimetric Evaluation of Heterogeneity Corrections for RTOG 0236: Stereotactic Body Radiation Therapy of Inoperable Stage I/II Non-Small Cell Lung Cancer

BackgroundApoptosis is a major mode of hematological tumor death after radiation. Early detection of apoptosis may be beneficial for cancer adaptive treatment. ^99mTc-HYNIC-annexinV...Full Text Available

143

Combined therapy of localized Ewing's sarcoma of bone: Analysis of results in 100 patients

PurposeUsing a retrospective analysis of treatment plans submitted from multiple institutions accruing patients to the RTOG #0236 non-small cell SBRT protocol, this...Full Text Available

2009-03-15

144

Acute myelogenous leukemia following chemotherapy and radiation for rectal cancer

From 1979 to 1986, 182 patients with biopsy proven diagnosis of Ewing's sarcoma of bone were observed. One hundred of the 182 patients (72 males, 28 females, median age 15.8 years) with localized disease and no previous treatment were treated with chemotherapy (VCR, ADM, CTX, D-ACT) for 15-18 months. Local treatment was radiotherapy (42 patients), surgery (31 patients), or a combination of both (27 pts). Radiation doses ranged from 45 to 64 Gy given with conventional fractionation. Median follow-up was 51.2 months (24-106). Overall and disease-free survival were, respectively, 58.7 and 42.6%. Resected patients tended to have a better local control (Surgery 93.6%, Surgery + Radiation therapy 92.6%, Radiation therapy 69.1%). Disease-free survival was significantly related to the volume of the primary tumor (bulky: 33.2%, not-bulky: 57.7%), to site (extremities 54.6%, central sites ...

145

Evaluation of the Inventories Released from Liquid Radwaste Treatment Systems of Wolsung Nuclear Power Units 3 and 4 Using Linear Regression Method

In August 1982, a 44-year-old man was diagnosed as having rectal cancer, histologically diagnosed as well differentiated adenocarcinoma, and abdominoperineal resection and colostomy were performed. Postoperatively, he received chemotherapy with mitomycin C up to a total dose of 100 mg. In September 1986, lung metastasis occurred and he was treated with a combination chemotherapy consisting of cisplatin, pirarubicin and 5-fluorouracil. In the following year, radiation treatment (total: 6900 rad) was given for a recurrent pelvic lesion. Peripheral blood on April 30, 1988, showed anemia, thrombocytopenia and appearance of myeloblasts, and a diagnosis of acute myelogenous leukemia (FAB: M1) was made. Combination chemotherapy (including aclarubicin, vincristine, behenoyl ara-C, daunorubicin, 6-mercaptopurine, cytarabine, etoposide and prednisolone) failed to induce remission and the patient died in June 1988. This case was thought to be one of ...

1989-03-01

146

Evaluation of the Inventories Released from Liquid Radwaste Treatment Systems of Wolsung Nuclear Power Units 3 and 4 Using Linear Regression Method

In the preparing stage of Final Safety Analysis Report (FSAR), the expected inventories of radwaste treatment systems are estimated. The inventory calculation plays an important role in the estimation of environmental radiation as well as nuclear power plant (hereafter referred to NPP) integrity, and further improvement of the public perception for NPP or radiation. The inventory has been accumulated and periodically measured for every NPP during the whole operation in Korea. But, a detailed analysis and database construction for the inventory have not still been carried out. For estimating the inventory change in this study, the radwaste treatment systems of Wolsung (hereafter referred to WS) nuclear power units 3 and 4 were selected as the reference systems. An analysis and prediction of the inventory change were performed for total activity released to environment during the whole operation. The ...

2006-07-01

147

Estimation of cancer risks from radiotherapy of benign diseases

In the preparing stage of Final Safety Analysis Report (FSAR), the expected inventories of radwaste treatment systems are estimated. The inventory calculation plays an important role in the estimation of environmental radiation as well as nuclear power plant (hereafter referred to NPP) integrity, and further improvement of the public perception for NPP or radiation. The inventory has been accumulated and periodically measured for every NPP during the whole operation in Korea. But, a detailed analysis and database construction for the inventory have not still been carried out. For estimating the inventory change in this study, the radwaste treatment systems of Wolsung (hereafter referred to WS) nuclear power units 3 and 4 were selected as the reference systems. An analysis and prediction of the inventory change were performed for total activity released to environment during the whole operation. The ...

2006-11-02

148

Estimation of cancer risks from radiotherapy of benign diseases

Background: The effective-dose method which was proposed by the ICRP (International Commission of Radiation Protection) for the estimation of risk to the general population from occupational or environmental, low-dose radiation exposure is not adequate for estimating the risk of cancer induction by radiotherapy of malignant or nonmalignant diseases. Methods:The risk of cancer induction by radiotherapy of benign diseases should be based on epidemiologic data directly derived from follow-up studies of patients who had been given radiotherapy for nonmalignant diseases in the past. Results: Risk factors were derived from epidemiologic studies of patients treated with irradiation for nonmalignant diseases to be used for selecting treatment options and optimizing treatment procedures. Conclusion: In most cases, cancer risks estimated by the effective-dose method may overestimate the true risks by one order of ...

2006-08-15

149

Concepts of radiotherapy treatment planning

Background: The effective-dose method which was proposed by the ICRP (International Commission of Radiation Protection) for the estimation of risk to the general population from occupational or environmental, low-dose radiation exposure is not adequate for estimating the risk of cancer induction by radiotherapy of malignant or nonmalignant diseases. Methods:The risk of cancer induction by radiotherapy of benign diseases should be based on epidemiologic data directly derived from follow-up studies of patients who had been given radiotherapy for nonmalignant diseases in the past. Results: Risk factors were derived from epidemiologic studies of patients treated with irradiation for nonmalignant diseases to be used for selecting treatment options and optimizing treatment procedures. Conclusion: In most cases, cancer risks estimated by the effective-dose method may overestimate the true risks by one order of ...

2006-08-01

150

The efficacy of low-dose radiation therapy and surgical resection for Ewing's sarcoma

Full text: Radiotherapy treatment planning (RTP) relies heavily on medical imaging. Until recently, the most important planning tool was the treatment simulator. The kilovoltage radiographic capabilities in a treatment simulator enabled the boundaries of treatment fields to be visualized with respect to bony anatomic landmarks. Perhaps the most important advance in treatment planning in recent years is the ability to visualize the passage of the beams with respect to a more accurate geometrical representation of the tumor and other soft tissue structures. This 'virtual simulation' uses a computer-based representation of a patient to determine the extent of the disease and the location of radiation sensitive normal tissue. Computer tomographic (CT) imaging produces a high-resolution three-dimensional representation of anatomy that can be correlated with other ...

2000-12-01

151

Accuracy of two heterogeneity dose calculation algorithms for IMRT in treatment plans designed using an anthropomorphic thorax phantom

Purpose: To evaluate the effect of low-dose radiation therapy and surgery on local control in patients with Ewing's Sarcoma. Materials and Methods: Between 1979 and 1995 24 patients (ages 4-47) with Ewing's sarcoma were treated with combined modality therapy that included multi agent chemotherapy, surgical resection, and radiation therapy. Twelve patients had metastatic disease at the time of presentation (pleura = 3, lung = 5, bone 4). Tumor location was central in 16 and peripheral in 8. Multi agent chemotherapy consisted of vincristine/actinomycin D/cyclophosphamide/doxorubicin in 19. The same agents with the addition of ifosfamide and etoposide were given in 5. The extent of resection was considered to be radical in 14 and of the 16 patients who received preoperative chemotherapy, 5 were found to have a pathologic complete response. All patients with lung metastases at diagnosis received whole-lung irradiation to 1400 cGy in 10 fractions. ...

1996-09-01

152

Monte Carlo-based investigation of effect of inhomogeneity in brachytherapy dose calculation - Part I

With the advent of intensity-modulated radiation therapy (IMRT), the inclusion of heterogeneity corrections is further complicated by the conformal delivery of many small beams forming steep dose gradients. Radiation treatment planning has evolved to take into account even small changes in tissue density so that the dose to tumor can be further optimized. However, different treatment planning systems incorporate different heterogeneity correction algorithms, and it is unclear whether any of these algorithms are superior to others in terms of accurately predicting delivered radiation doses relative to measurement in a clinical setting. The purpose of this study was to determine the accuracy of heterogeneity dose calculations from two widely used IMRT treatment planning systems (Pinnacle and Corvus) against measurement. These two systems handle heterogeneity dose ...

2007-05-01

153

Dosimetric evaluation and therapeutic response to iodine-131 labelled lipiodol in treatment of hepatocellular carcinomas; Evaluation dosimetrique et reponse therapeutique de la curietherapie metabolique des hepatocarcinomes par le lipiodol marque par l'iode 131

Brachytherapy refers to short distance treatment of cancer with radiation from small, encapsulated radionuclide sources. This type of treatment is given by placing sources directly into or near the volume to be treated. The dose is then delivered continuously, either over a short period of time (temporary implants) or over the lifetime of the source to a complete decay (permanent implants). This technique is extensively used in the treatments of gynecological, breast, prostate, head and neck, and other soft tissue cancers. The clinical outcomes of this treatment depend on accurate dosimetry and dose delivery. The patient is generally considered to be water equivalent. So the treatment planning system software generally is based on measured or calculated dose distributions in homogenous water medium. In real situation, the treatment volume is ...

2009-04-01

154

Salmonella radicidation of poultry carcasses

Faced with increasing indications for the use of iodine-131 labelled lipiodol in the treatment of hepatocellular carcinoma (HCC), it appears essential to develop an individualized dosimetrY so we can predict the potential effectiveness of this treatment and adjust the activity to be injected. We developed a dosimetric protocol based on imagery and dedicated to calculation of the tumoral dose during the treatment of hepatocellular carcinoma by iodine-131 labelled lipiodol. This concept was developed on a SPECT- CT gantry, and integrates corrections for the phenomena of attenuation, diffusion and dead time. The dose is calculated according to the formalism proposed by the Medical Internal Radiation Dose Committee (MIRD). This protocol was applied to a series of 41 patients in the framework of a retrospective study. The results obtained in terms of biodistribution are compatible with previously published ...

2006-12-15

155

Gene expression analysis after low dose ionising radiation exposure of the developing organism

This thesis reports investigations using gamma-radiation to decontaminate poultry carcasses. The application to foods of doses of ionizing radiation sufficient to reduce the number of viable specific non-sporeforming pathogenic microorganisms so that none is detectable in the treated food by any standard method is termed radicidation. The doses used in this study were at such a level that no undesirable or unfavourable side-effects occurred. The effects of these doses were studied on salmonellae and other microorganisms present in, or associated with poultry carcasses and in liquid and on solid culture media as well. Decimal reduction (D_1_0) values were estimated. These represent the dose (kGy) required to achieve a reduction in initial colony count from N_0 to 0.1 N_0. Together with the estimation of the numbers of Salmonella present per carcass the data were used to predict the effect of an ionizing radiation ...

2005-09-22

156

Verification of electron beam therapy with storage phosphor images: Precision of field placement

Measuring gene expression using microarrays is relevant to many areas of biology and medicine, such as follow up of developmental stages and diseases onset, and treatment study. Since there can be tens of thousands of distinct probes on an array, each micro array experiment can accomplish the equivalent number of genetic tests in parallel. Arrays have therefore dramatically accelerated many types of investigations. For example, microarrays can be used to identify stress response genes by comparing gene expression in challenged versus normal cells. In the Molecular and Cellular Biology lab (MCB), the micro array experiments are performed within the Genomic Platform, fully equipped to analyse either the behaviour of bacteria during long space flight, the effect of low dose ionising radiation on the developing organism in mice, or the human individual radiation sensitivity. For the low dose effect, two main stages of ...

2007-09-01

157

Brachytherapy in the Treatment of Cholangiocarcinoma

Portal verification images were generated from the photon contamination in electron beams produced by a linear accelerator during treatment of patients receiving high-energy electron radiation therapy (8-14 MeV). An experimental storage phosphor system was used to record the images and display them on laser-printed film. Images were obtained from four or more treatment fractions from 21 cases of head and neck cancer. Precision in field placement was estimated by determining the position of a selected anatomic landmark relative to the center of the field for each series of images. The average standard deviation in the field-position measurements was 3.8 mm. Several procedural problems were also detected and corrected after review of the verification images. The results indicate that the emphasis placed on monitoring and control of field-positioning error in high-energy electron treatments should be ...

1990-04-01

158

Irradiation with and without razoxane in the treatment of incompletely resected or inoperable recurrent rectal cancer. Results of a small randomized multicenter study

Purpose: To examine the role of brachytherapy in the treatment of cholangiocarcinomas in a relatively large group of patients. Methods and Materials: Using the Surveillance, Epidemiology and End Results database, a total of 193 patients with cholangiocarcinoma treated with brachytherapy were identified for the period 1988-2003. The primary analysis compared patients treated with brachytherapy (with or without external-beam radiation) with those who did not receive radiation. To try to account for confounding variables, propensity score and sensitivity analyses were used. Results: There was a significant difference between patients who received radiation (n = 193) and those who did not (n = 6859) with regard to surgery (p < 0.0001), race (p < 0.0001), stage (p < 0.0001), and year of diagnosis (p <0.0001). Median survival for patients treated with brachytherapy was 11 months (95% confidence ...

2010-11-01

159

Analysis of Result of Treatment of Ewing's Sarcoma

Background and Purpose: In an earlier phase II study, irradiation together with razoxane was shown to improve local control in recurrent rectal cancer. Therefore, the Austrian Society of Radiooncology (OeGRO) initiated a randomized controlled trial in 1992 to compare this combined treatment versus radiation therapy alone. Patients and Methods: Between 1992 and 1999, 36 patients with localized recurrences of rectal cancer were randomized to receive radiotherapy without (group A) or with razoxane (group B). The prognostic variables of the two groups were similar except for a longer median latency period from initial surgery to local recurrence in group A. High-energy photons with daily fractions between 170 and 200 cGy were used. The median total radiation dose was 60 Gy in each group. The patients in group B received a median razoxane dose of 9.6 g (range, 5-12 g). Main outcome measures were local control, overall survival, ...

2007-07-15

160

Irradiation as an alternative post harvest treatment

Total 125 patients with primary and metastatic Ewing's sarcoma were treated in various ways between 1963 to 1977. Patients were divided into 3 groups according to the treatment methods. Group 1 was nonprotocol patients with or without chemotherapy. Total 58 patients were entered. Group 1 was divided into 2 subgroups. 33 patients were treated locally without chemotherapy and 25 patients were treated with local therapy and nonprotocol chemotherapy. Group 2 was treated with local therapy and plus T-2 regimen multiagent chemotherapy. 29 patients were entered. Group 3 was treated with local therapy and T-6 regimen multiagent chemotherapy. 38 patients were entered. Local treatments for primary tumor were surgery and/or radiation therapy. Radiation dose ranged between 2,000 and 8,000 rad. Patients with pulmonary metastases received bilateral pulmonary RT. Local recurrence rate was analyzed according to ...

1984-06-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

Induction of hepatocellular carcinoma in nonhuman primates by chemical carcinogens

This current world population has significantly added to the pressures placed upon our finite resources and our resulting ability to feed ourselves. In order to cope with current and future demands, the two established lines of action, that is, reduced population growth and expansion of agricultural production, must be supplemented with the parallel activity of reducing food losses during and after harvest. For developing countries in particular, enormous post-harvest losses result from spillage, contamination, pests and physiological deterioration during storage. Studies in these countries indicate that post-harvest losses are enormous and amount to tens of millions of tons per year valued at billions of dollars. Programs to reduce post-harvest losses, if applied properly, can result in realistic yield increases between 10 and 30%, which can be directly converted into increased consumption for humans. Post-harvest losses vary greatly and are a function of the crop variety, pest ...

1997-10-27

162

Results of electron beam therapy using intra-oral cone for carcinoma of the oral tongue

Several compounds were evaluated in nonhuman primates for their potential to induce neoplasms, especially hepatocellular carcinoma (HCC). The compounds can be classified into three groups: food contaminants, model rodent carcinogens, and nitrosamines. All three compounds in the food contaminants group, namely, aflatoxin B1, sterigmatocystin, and methylazoxymethanol acetate, induced HCC. None of the model rodent carcinogens tested consistently induced HCC in rhesus and cynomolgus monkeys. Three of four nitrosamines evaluated induced HCC in rhesus and cynomolgus monkeys. One nitrosamine, diethylnitrosamine, is a predictable and potent inducer of HCC and is useful for establishment of a nonhuman primate model for numerous oncologic studies.

1989-01-01

163

Renal artery stenosis after radiotherapy for Ewing's sarcoma

Retrospective analyses were performed to evaluate the therapeutic efficacy of intra-oral cone (IOC) radiation therapy for carcinoma of the oral tongue, especially about its faculty of local control and complications. Thirty-nine patients with squamous cell carcinoma of the oral tongue were treated with IOC radiation therapy alone or in combination with external irradiation. IOC radiation therapy was given not only for T1 and T2, but also for T3 tumors. Hypofractionation was used for IOC radiation therapy. The 2 year local control rates, including surgical salvage, for T1, T2, T3 and T4 were 100%, 73.3%, 40% and 0%, respectively. The 5 year actuarial survival rates for Stage I, II, III and IV were 100%, 65.3%, 35.4% and 0%, respectively. The incidences of radiation complications, i.e. soft tissue ulceration and osteoradionecrosis, were 42.9% and 2.9%, respectively. It is suggested ...

1992-07-01

164

Sequential chemical treatment of radium species in TENORM waste sludge produced from oil and natural gas production.

Background: the fact that therapeutic irradiation can induce significant stenosis in the arteries of the head, neck, and chest, as welt as in the aorta and the iliac arteries, is familiar in daily practice and well documented in the literature. By contrast, radiation-induced renal artery stenosis seems to be a less widely known complication. Patients and methods: the sudden onset of medically refractory arterial hypertension and coma in a 27-year-old man is reported, who had been treated at age 20 with chemotherapy and radiotherapy for Ewing's sarcoma in the lumbar region. This treatment had been performed at the hospital of Sion, Switzerland in 2001. Also, the relevant literature from 1965 to 2007 is reviewed to underscore various aspects of this problem and to demonstrate the clinical relevance of renal artery stenosis as a potential long-term sequela of radiotherapy. Conclusion: radiation-induced renal artery stenosis ...

2008-09-01

165

Sequential chemical treatment of radium species in TENORM waste sludge produced from oil and natural gas production

This paper is dedicated to the treatment of sludge occurring in frame of the Egyptian produced from oil and gas production. The activity levels of three radium isotopes: Ra-226 (of U-series), Ra-228 and Ra-224 (of Th-series) in the solid TENORM waste (sludge) were first evaluated and followed by a sequential treatment for all radium species (fractions) presented in TENORM. The sequential treatment was carried out based on two approaches 'A' and 'B' using different chemical solutions. The results obtained indicate that the activity levels of all radium isotopes (Ra-226, Ra-228 and Ra-224) of the environmental interest in the TENORM waste sludge were elevated with regard to exemption levels established by IAEA [International Atomic Energy Agency (IAEA), International basic safety standards for the protection against ionizing radiation and for the safety of radiation sources. ...

2008-04-18

166

Intraoperative radiation therapy at the National Cancer Institute: technical innovations and dosimetry

This paper is dedicated to the treatment of sludge occurring in frame of the Egyptian produced from oil and gas production. The activity levels of three radium isotopes: Ra-226 (of U-series), Ra-228 and Ra-224 (of Th-series) in the solid TENORM waste (sludge) were first evaluated and followed by a sequential treatment for all radium species (fractions) presented in TENORM. The sequential treatment was carried out based on two approaches 'A' and 'B' using different chemical solutions. The results obtained indicate that the activity levels of all radium isotopes (Ra-226, Ra-228 and Ra-224) of the environmental interest in the TENORM waste sludge were elevated with regard to exemption levels established by IAEA [International Atomic Energy Agency (IAEA), International basic safety standards for the protection against ionizing radiation and for the safety of ...

2009-01-30

167

Treatment of hepatocellular carcinoma (HCC) with radiolabeled Lipiodol: a preliminary report

The technical complexity of intraoperative radiotherapy (IORT) requires modification of the standard physical and dosimetric methods used in external electron beam therapy. At the National Cancer Institute, a number of technical innovations have been integrated into ongoing clinical studies of IORT. These include: (1) an electron beam applicator system that is significantly different from other IORT systems and includes customized squircle applicators; (2) peripheral dose shields; (3) a modified surgical table replacing the standard radiation treatment couch; and (4) routine use of multiple IORT fields that necessitates field matching. The IORT applicator system and related devices and techniques are dosimetrically characterized in detail both for use in the IORT program and in order to illustrate many useful facets of electron dosimetry.

1985-07-01

168

The effect of X-radiation on reticuloendothelial system and its treatment with radiodetoxified-endotoxin and trace elements in rats

Fatty acid esters such as Lipiodol or Ethiodol are known to selectively localize in vascular hepatocellular carcinomas (HCC), following intraarterial hepatic administration. Lipiodol was labeled with radioactive /sup 131/I and administered in 47 patients with HCC for both imaging and therapy. The short term preliminary results suggest radiolabeled Lipiodol is effective in eliminating ascites, shrinking the tumor by a high internal radiation dose, and in improving symptomatology of these tumors. In the future, /sup 90/Y, which is a stronger pure beta-emitter (maximum beta energy of 2.27 MeV, a half life of 64 h, and a maximum penetration or beta range of 11mm), than /sup 131/I will be used for more effective treatment of HCC.

1987-12-01

169

Association of area sociodemographic characteristics and capacity for treatment with disparities in colorectal cancer care and mortality

A new in vivo method has been developed for the precise observation of RES activity. Both Escherichia coli endotoxin 100 #mu#g/100 g i.v. (LPS) and radiodetoxified endotoxin 100 #mu#g/100 g body weight i.v. (RD-LPS, TOLERIN) increased the granulopectic activity of RES. The RD-LPS was more effective. The preparation containing trace elements also increased the activity of RES. The treatment consisting of the use of both trace elements and RD-LPS proved to be the most effective. The activity of RES was inversely proportional to various doses of X-ray irradiation (7, 8, 9 Gy). Trace elements and RD-LPS even improved the immunity system of animals having deteriorated RES. (N.T.).

170

British Library Electronic Table of Contents (United Kingdom)

AbstractBACKGROUND: Disparities in treatment and mortality for colorectal cancer (CRC) may reflect differences in access to specialized care or other characteristics of the area where an individual lives. METHODS: Surveillance, Epidemiology and End Results Program-Medicare data for seniors diagnosed with CRC were linked to area measures of the sociodemographic characteristics and the capacity of surgeons, medical oncologists, and radiation oncologists. Outcomes included receipt of stage-appropriate CRC care and mortality. RESULTS: After adjustment, blacks and Hispanics were less likely than whites to undergo surgery (odds ratio [OR] 0.57, 95% confidence interval (CI) 0.52-0.63 and OR 0.82, 95% CI 0.70-0.95, respectively). Individuals who lived in areas with the highest tertile of surgeon c...

2011-01-01

171

Adaptive Management of Liver Cancer Radiotherapy

British Library Electronic Table of Contents (United Kingdom)

Adaptive radiation therapy for liver cancer has the potential to reduce normal tissue complications and enable dose escalation, allowing the potential for tumor control in this challenging site. Using adaptive techniques to tailor treatment margins to reflect patient-specific breathing motions and image-guidance techniques can reduce the high dose delivered to surrounding normal tissues while ensuring that the prescription dose is delivered to the tumor. Several treatment planning and delivery techniques have been developed for use in the liver, including a margin to encompass the full breathing motion, mean position techniques, which evaluate the probability of tumor location during breathing, breath hold, gating, and tracking. Patient selection, clinical workflow, and quality assurance m...

2010-01-01

172

The development of automatic surface dose-rate measuring and recording system for radioactive waste drum

Reports of the second All-Union conference on the chemistry of transplutonium elements (Dmitrovgrad, June 21-23, 1963)

The system which is performed the transportation and measurement of drum automatically to measure the surface dose-rate of radioactive waste drum and can inspect place of contaminated sources and precise dose-rate within a drum according to measuring many places equally at the same time has been developed. It is expected that the system be used to minimized radiation exposure of workers and manage the drum effectively according to established at the production facilities as well as the radioactive waste treatment facilities. (author). 7 refs., 9 tabs., 16 figs.

173

Radiolysis of selected antibiotics and their toxic effects on various aquatic organisms

The nine papers presented at this conference cover the following topics: the systematization, condensed description, and prediction of sets of anion exchange extraction constants on the basis of their statistical computer treatment; characteristics and uses of solid extractants containing D2EHPA and TBP for separating the transplutonium elements; enrichment of americium 242m and americium 242 by the Szilard-Chalmers method; an x-ray diffraction pattern analysis for transplutonium compounds; the radiation chemistry of americium; and the effects of alpha irradiation on the behavior of americium in perchlorate solutions.

1987-05-01

174

New results for 5-point functions

This study was conducted to investigate the decomposition of three {gamma}-irradiated antibiotics (e.g., tetracycline, sulfamethazine, and lincomycin) and to compare the toxic effects on Daphnia magna, Vibrio fischeri, and Pseudokirchneriella subcapitata. The median cell growth inhibition concentrations (IC{sub 50}) of tetracycline, lincomycin, and sulfamethazine for P. subcapitata dramatically increased (e.g., toxicity decreased) after radiolysis. The results demonstrated that {gamma}-radiation treatment was efficient to decompose antibiotics and thereby their toxicity on P. subcaptitata remarkably decreased due to reduced parent compounds.

2009-04-15

175

Megavoltage electron beam therapy in the treatment of basal and squamous cell carcinomata of the pinna

Bhabha scattering is one of the processes at the ILC where high precision data will be expected. The complete NNLO corrections include radiative loop corrections, with contributions from Feynman diagrams with five external legs. We take these diagrams as an example and discuss several features of the evaluation of pentagon diagrams. The tensor functions are usually reduced to simpler scalar functions. Here we study, as an alternative, the application of Mellin-Barnes representations to 5-point functions. There is no evidence for an improved numerical evaluation of their finite, physical parts. However, the approach gives interesting insights into the treatment of the IR- singularities. (orig.)

2007-12-15

176

Induction of sterility in adults of Earias vittella Fabricius through late pupal irradiation

Forty-three patients with basal and squamous cell carcinomata arising on the pinna were treated radically using a 10 MeV electron beam. The technique and dosage are described and discussed. Primary cancer control with retention of the pinna was achieved in 34 patients. Salvage pinnectomy was performed in four patients for recurrence and one patient for radiation necrosis. Two patients with large primary tumours failed to resolve and died of their disease. The advantages for the patient of the policy of primary radical electron beam therapy are discussed.

1982-05-01

177

INEEL Advanced Radiotherapy Research Program Annual Report 2001

Studies on pupal irradiation of Earias vittella Fabricius, were undertaken to determine the optimum dose for sterile and competitive adults. Late pupae were irradiated with gamma radiation doses ranging from 150 to 300 Gy. Emerging adults were normal and without malformation. When males that emerged from irradiated pupae were crossed with normal female, fecundity as well as longevity was comparable to control, but there was drastic reduction in percent egg hatch in all the treatments. However, when females emerging from irradiated pupae were crossed with normal male, there was reduction in the fecundity as well as fertility and this effect was dose dependent. (author).

178

INEEL Advanced Radiotherapy Research Program Annual Report 2001

This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

2002-04-01

179

Guidelines on the medical therapy of persons accidentally overexposed to ionizing radiations. External contamination

This report summarizes the major activities and accomplishments of the Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Radiotherapy Research Program for calendar year 2001. Applications of supportive research and development, as well as technology deployment in the fields of chemistry, radiation physics and dosimetry, and neutron source design and demonstration are described. Contributions in the fields of physics and biophysics include development of advanced patient treatment planning software, feasibility studies of accelerator neutron source technology for Neutron Capture Therapy (NCT), and completion of major modifications to the research reactor at Washington State University to produce an epithermal-neutron beam for NCT research applications.

2002-04-30

180

Department of Nuclear Safety Research and Nuclear Facilities annual report 1995

The document represents a guide for the external decontamination of persons accidentally radio contaminated due to the use, production or transport of radioactive materials. The general conditions, from the medical point of view, to be kept in mind, in the event of accidental overexposures as decontamination treatment and the handling of samples are detailed throughout report. The external contamination without injury in skin or with wound its considered. The distribution of measures and responsibilities for the therapy of the irradiated patients with radioactive materials are enumerated. The preparations of decontaminate solutions are detailed in this work. Moreover, forms for the reception, physical evaluation of the patient and external contamination are presented. (author)

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

181

A case of Ewing's sarcoma treated successfully with chemotherapy and radiotherapy

The report presents a summary of the work of the Department of Nuclear Safety Research and Nuclear Facilities in 1995. The department`s research and development activities are organized in three research programmes: Radiation Protection, Reactor Safety, and Radioanalytical Chemistry. The nuclear facilities operated by the department include the Research Reactor DR3, the Isotope Laboratory, the Waste Treatment Plant, and the Educational Reactor DR1. Lists of staff and publications are included together with a summary of the staff`s participation in national and international committees. (au) 5 tabs., 21 ills.

1996-03-01

182

Some comments on BEIR III

We encountered a case of Ewing's sarcoma. The patient was a 19 year-old girl, who visited a local physician because of pain in the left scapular region, and was referred to us. Roentgenograms of her left scapula revealed an irregular moth-eaten shadow which was suspected to be a malignant bone tumor. The histological diagnosis of Ewing's sarcoma was comfirmed by needle biopsy. The initial stage of treatment consisted of radiation therapy (6000 rads) and chemotherapy (VAC and ADR). At the end of the initial stage, the symptoms were improved, the size of the local lesion was reduced on the roentgenogram and there was no evidence of distant metastases. (author).

183

Radiation technology of wood-plastic composite materials

... organizations irradiation radiation doses radiation effects RADIATIONS.

1982-01-01

184

Radiation chloration sulfochloration and sulfooxidation of organic compounds

... radiation effects RADIATIONS. WOOD-PLASTIC COMPOSITES.

1981-10-02

185

Hyperfractionated radiation therapy for incompletely resected supratentorial low-grade glioma. A phase II study

... halogenation ionizing radiations kinetics radiations reaction kinetics

186

The enhanced genomic instability was induced by alpha particle and low-energy ion irradiation in somatic cells of Arabidopsis thaliana

Background and purpose: In order to investigate the feasibility, toxicity and antitumor efficacy of hyperfractionated radiation therapy, 37 adult patients with incompletely resected supratentorial low-grade glioma were entered into a phase II study. Materials and methods: The radiation therapy dose was 55 Gy in 50 fractions in 25 treatment days over 5 weeks to the tumor plus a 2-cm margin, with an additional 17.6 Gy given in 16 fractions in 8 treatment days over 1.5 weeks to the tumor plus a 1-cm margin, using 1.1 Gy b.i.d. fractionation with a 6 h interfraction interval. The total tumor dose was 72.6 Gy in 66 fractions in 33 treatment days over 6.5 weeks. Results: The median survival time (MST) for all 37 patients has not yet been attained, while 5- and 7-year survival rates were 75% and 69%, respectively. The median time to tumor progression (MTP) has also not yet been attained, ...

1998-10-01

187

Radiation therapy for Ewing's sarcoma: Results from Memorial Sloan-Kettering in the modern era

Although low-energy ion radiation has been proven to have a wide range of biological effects and led to fruitful achievements as a new mutagenic source for genetic modification, there still exist some disputes about its mutagenic mechanisms because of its short-penetrating property. In present research, Arabidopsis thaliana transgenic for GUS recombination substrate was used to evaluate the genomic instability induced by irradiations of alpha particle (3.3MeV) and Low-energy-Argon ion (30 KeV). A pronounced effects of alpha particle irradiation to Arabidopsis thaliana seedlings and Argon ion irradiation to seeds on the somatic homologous recombination frequency (sHRF) were reported. The sHRFs increased 1.88-fold and 2.42-fold, respectively, which indicated that the short-penetrating radiation could effectively induce the plant genomic instability in either dry seeds or seedlings with active metabolism. The local alpha particle irradiation of ...

2008-08-12

188

Influence of gamma rays and some pre and post harvest treatments on behavior of some fruits during cold storage

Purpose: To evaluate the outcomes of patients with Ewing's sarcoma family of tumors (ESFT) treated with modern radiotherapy techniques with MRI along with optimal chemotherapy. Methods and Materials: The records of all 60 patients with ESFT who received radiation to the primary site between 1990 and 2004 were reviewed. All patients received chemotherapy, including vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide. Radiation was used as the sole modality for local control in 31 patients and was given either before (n = 3) or after surgical resection (n = 26) in the remainder. All patients had MRI and CT scan-based treatment planning, and 43% received intensity-modulated radiation therapy. Radiation doses ranged from 30 Gy to 60 Gy (median, 51 Gy), and 35% received hyperfractionated radiotherapy. Results: Median age was 16 years (range, 2-40 years). Because of ...

2006-02-01

189

The review of radioactive waste management in the world

Apricot fruits usually harvested relatively mature but hard enough to withstand-post harvest handling through the marketing chain. These fruits have considerably lower edible quality than tree-ripened fruit. Fruit quality can be improved by delaying harvest least until physiological maturation is completed on the tree (Bonghi et al. 1999) Apricots containing 11% soluble solids concentration, or higher are in high demand by consumers, as fruit have developed considerable taste, aroma and handling for long distance markets. (Kader, 1999). These fruit will be highly perishable, so rapid cold storage to the lowest safe temperature and supplementary treatments (Mc Donald et al, 1999) such as irradiation with the recommend doses (Sillano et al, 1994) or pre-storage heat treatments will be necessary to retard ripening (mainly softening) during 1-2 weeks post harvest life necessary for distribution to distant markets (Mc Donald et al 1999). Therefore, ...

2003-03-01

190

The combination therapy with hepatic arterial infusion chemotherapy and radiation therapy for unresected intrahepatic cholangiocarcinoma

Radioactive waste is generally classified on the basis of how much radiation and the type of radiation it emits as well as the length of time over which it will continue to emit radiation. Many activities dealing with radioactive materials produce nuclear wastes, including civilian nuclear power programs (nuclear Power plant operations and nuclear fuel-cycle activities), defense nuclear programs (nuclear weapons production, naval nuclear reactor programs, and related R and D), and industrial and institutional activities (scientific research, medical operations, and other industrial uses of Radioisotopic sources or Radio chemicals). To minimize the potential adverse health and environment impacts to people and other systems including of animals, plant and etc, during the entire lifetime of the radionuclides involved, nuclear waste must be carefully and properly managed. The scope of nuclear - waste management encompasses ...

191

Prevention and Treatment of Functional and Structural Radiation Injury in the Rat Heart by Pentoxifylline and Alpha-Tocopherol

The outcome was retrospectively examined and prognostic factors were discussed for arterial chemo-infusion therapy (ACT) through an implanted reservoir system and radiation therapy (RT) in patients with unresectable intrahepatic cholangiocarcinoma (CCC). ACT plus RT were conducted to 25 patients (mean age 61.7 y, M/F 12/13, stage III-IVB) during 10 years from 1996 to 2005 with various regimens of cisplatin (CDDP), 5- fluorouracil (FU), epirubicin (FARM), mitomycin C (MMC) plus 39-50 Gy of radiation in a fractionated manner partly involving internal RT (2 cases, 15 Gy) and RT for metastatic bone (1, 25 Gy). The survival rates at 1, 2 and 3 years after ACT+RT were respectively 52.5, 43.7 and 28.1%; total efficacy (PR) was 36% (9/25) at 6 months; and significantly good prognostic factors were found to be female and absence of metastasis remote and/or lymphatic around artery. Authors concluded that ACT+RT was a meaningful ...

2007-11-01

192

British Library Electronic Table of Contents (United Kingdom)

Purpose Radiation-induced heart disease (RIHD) is a severe side effect of thoracic radiotherapy. This study examined the effects of pentoxifylline (PTX) and a-tocopherol on cardiac injury in a rat model of RIHD. Methods and Materials Male Sprague-Dawley rats received fractionated local heart irradiation with a daily dose of 9 Gy for 5 days and were observed for 6 months after irradiation. Rats were treated with a combination of PTX, 100 mg/kg/day, and a-tocopherol (20 IU/kg/day) and received these compounds either from 1 week before until 6 months after irradiation or starting 3 months after irradiation, a time point at which histopathologic changes become apparent in our model of RIHD. Results Radiation-induced increases in left ventricular diastolic pressure (in mm Hg: 35 +- 6 after sham...

2008-01-01

193

Effects of irradiation in medicinal and eatable herbs

Development of functional foods for radiation workers

For ages, herbs have been used as medicine and food. Nowadays, the interest in phytotherapeutics is increasing as well as the consumer attention. Some biochemical compounds synthesized by plants as alkaloids, phenolics, flavonoids, essential oils, tannins and vitamins, influence the composition of these plant pharmacologicals, which may produce various reactions in the human body. The microbial contamination in these raw plant materials is common, and the radiation processing is one appropriate technique for the reduction of microorganism. In herbs used as food products, the changes in total #beta#-carotene and flavonoids upon the radiation treatment were tested. The powdered and dehydrated herbs were irradiated with "6"0Co gamma rays applying doses of 0, 10, 20 and 30 kGy. The botanical species investigated were rosemary (Rosmarinus officinalis Linne), watercress (Nasturtium officinale R. Br), artichoke (Cynara scolymus ...

2002-03-01

194

Biological wound dressings sterilized with gamma radiation: Mexican clinical experience

In searching modulators of immunity and hematopoiesis among natural products, being used as foods, six herbs exhibited lymphocyte proliferation in vitro, and six exhibited augmentation of hematopoietic cell growth. The combined treatments showed synergistic effects of lymphocyte proliferation and of hematopoietic cell growth. On the other hand, we found four effective oriental medicinal prescriptions, used as energy tonic or blood-building decoctions, for survival and regeneration of hematopoietic cells and for protection of stem cells of intestinal crypt in irradiated mice. On the basis of these results, extracts from combinations of herbs were made in expectation of higher effects in the three respects. In immuno modulation activity by the two combinations of herbs was confirmed in mice. In culture of bone narrow cells, growth improvement of non-adherent precursor and induction of cytokine expression by herb mixture extracts were observed. In evaluation of ...

2000-03-01

195

Utilisation of gamma radiation of Cobalt-60 as quarantine treatment of medicinal plant, aromatic and seasoning plants dehydrated infested by Lasioderma serricorne (Fabricius, 1792) (Coleoptera, Anobiidae) and Plodia interpunctella (Hubner, 1813) (Lepidoptera, Pyralidae); Utilizacao da radiacao gama do Cobalto-60 como tratamento quarentenario de plantas medicinais, aromaticas e condimentares desidratadas infestadas por Lasioderma serricorne (Fabricius, 1792) (Coleoptera, Anobiidae) e Plodia interpunctella (Hubner, 1813) (Lepidoptera, Pyralidae)

Biological wound dressings sterilized with gamma radiation, such as amnion and pig skin, are a reality in Mexico. These tissues are currently processed in the tissue bank and sterilized in the Gamma Industrial Irradiation Plant; both facilities belong to the Instituto Nacional de Investigaciones Nucleares (ININ) (National Institute of Nuclear Research). With the strong support of the International Atomic Energy Agency, the bank was established at the ININ and the Mexican Ministry of Health issued its sanitary license on July 7, 1999. The Quality Management System of the bank was certified by ISO 9001:2000 on August 1, 2003; the scope of the system is 'Research, Development and Processing of Biological Tissues Sterilized with Gamma Radiation'. At present, more than 150 patients from 16 hospitals have been successfully treated with these tissues. This paper presents a brief description of the tissue processing, as well as the present Mexican ...

2007-11-01

196

Surgical adjuvant therapy in colon carcinoma: a human tumor spheroid model for evaluating radiation sensitizing agents

The research had as objective the use of the gamma radiation of the Cobalto-60 as quarantine treatment of the medicinal plant, aromatic and seasoning plants dehydrated infested by Lasioderma serricorne and Plodia interpunctella determining the disinfestation doses to attend the criterion in the not emergency of adults of the species in study and analysing through the Chromatography of Thin Layer the effect of the gamma radiation of the cobalto-60 on the active principle of extract dehydrated of Chamomilla recutita, Pimpinella anisum, Origanum vulgare, Cymbopogon citratus, Ocimum basilicum and Thymus vulgaris. The work was developed in the Laboratorio de Inseticidas in the Instituto Biologico in Sao Paulo in the period of August of 2005 the June of 2007. The radiation source used gamma was an experimental irradiator of Cobalto-60, model Gamacell 220, located in the Instituto de Pesquisas Energeticas e ...

2007-07-01

197

Evaluation of fungal bio burden and mycotoxins presence in irradiated samples of medicinal plants purchased from wholesale and retail market

HT-29 human colon tumor cells growing as spheroids have been evaluated as a model system for measuring the response of human colon tumor cell to antineoplastic agents. HT-29 cells have been capacity to form spheroids up to 1 mm or more in diameter when grown in spinner culture. The multicellular HT-29 spheroids develop hypoxic centers reflecting the cellular conditions found in human cancer treatment, i.e., nutritionally deficient hypoxic cells that are felt to be a significant source of both radiation and chemotherapy clinical treatment failures. Spheroids of increasing size were radiated and then dispersed into single cells for colony survival assay. Compared with irradiated single cell suspensions, the spheroid cells demonstrated a significant increase in radioresistance. Growing spheroids developed a complex radiation survival curve which was variable with respect to size of the ...

198

Actual and future strategies in interdisciplinary treatment of medulloblastomas, supratentorial PNET and intracranial germ cell tumors in childhood

This present study evaluated the effect of gamma radiation on the fungal survival in packed medicinal plants, purchased from wholesale and retail market, in different period (0 and 30 days) after the treatment. Five kind of medicinal plants (Peumus boldus, Camellia sinensis, Maytenus ilicifolia, Paullinia cupana and Cassia angustifolia), were collected from different cities of Sao Paulo State, and submitted to irradiation treatment using a 60Co source (type Gammacell 220) with doses of 5,0 kGy and 10 kGy and at dose rate of 3.0 kGy/h. Non-irradiated samples (control group) were used for fungal counts and serial dilutions from 10-1 to 10-6 of the samples were seeded in duplicates and plated using the surface culture method in Dichloran 18% Glycerol Agar (DG 18) and were counted after five days at 25 deg C. The control group revealed the presence of genera Aspergillus and Penicillium, which are known as toxigenic fungi and a ...

2006-12-20

199

A clinical perspective on common forms of acquired heterotopic ossification

Methods: Systemic irradiation of neuroaxis is an essential part in the management of medulloblastoma, stPNET and intracranial germ cell tumors. The introduction of quality assurance programs in radiooncology assures a precise radiotherapy of target volumes and is a prerequisite to improve survival. Results: Hyperfractionated radiotherapy has the potential of increasing dose to tumor more safely without increasing the risk for late adverse effects. Pilot studies revealed excellent tumor control in medulloblastoma with acceptable acute toxicity and a long-term survival of up to 96%. In medulloblastoma stereotactic radiation techniques reveal an acceptable toxicity and promising results in tumor control in recurrent disease or as primary treatment. They are now part of future treatment protocols in case of persisting residual tumor. Radiotherapy alone in pure germinoma is continuously yielding high cure rates. In secreting ...

2001-09-01

200

A clinical perspective on common forms of acquired heterotopic ossification

The clinical courses of heterotopic ossification (HO) as a consequence of trauma and central nervous system insults have many similarities as well as dissimilarities. Detection is commonly noted at two months. The incidence of clinically significant HO is 10%-20%. Approximately 10% of the HO is massive and causes severe restriction in joint motion or ankylosis. The most common sign and symptom are decreased range of motion and pain. The locations are the proximal limbs and joints. Sites of HO about a joint may vary according to the etiology of the HO. Roentgenographic evolution of HO occurs during a six-month period in the majority of patients. Treatment modalities include diphosphonates, indomethacin, radiation, range of motion exercises, and surgical excision. Surgical timing differs according to etiology: traumatic HO may be resected at six months; spinal cord injury HO is excised at one year; and traumatic brain injury HO is removed at 1.5 ...

1991-02-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

201

Radiation therapy in Ewing's sarcoma: an update of the CESS 86 trial

The clinical courses of heterotopic ossification (HO) as a consequence of trauma and central nervous system insults have many similarities as well as dissimilarities. Detection is commonly noted at two months. The incidence of clinically significant HO is 10%-20%. Approximately 10% of the HO is massive and causes severe restriction in joint motion or ankylosis. The most common sign and symptom are decreased range of motion and pain. The locations are the proximal limbs and joints. Sites of HO about a joint may vary according to the etiology of the HO. Roentgenographic evolution of HO occurs during a six-month period in the majority of patients. Treatment modalities include diphosphonates, indomethacin, radiation, range of motion exercises, and surgical excision. Surgical timing differs according to etiology: traumatic HO may be resected at six months; spinal cord injury HO is excised at one year; and traumatic brain injury HO is removed at 1.5 ...

202

Clinical implementation of a convolution based algorithm for 3D treatment planning

Purpose: We present an update analysis of the multiinstitutional Ewing's sarcoma study CESS 86. Methods and Materials: From January 1986 through June 1991, 177 patients with localized Ewing's sarcoma of bone, aged 25 years or less, were recruited. Chemotherapy consisted of four 9-week courses of vincristine, actinomycin D, cyclophosphamide, and adriamycin (VACA) in low-risk tumors (extremity tumors =# 100 cm"3). Local therapy was an individual decision in each patient and was either radical surgery (amputation, wide resection) or resection plus postoperative irradiation with 45 Gy or definitive radiotherapy with 60 Gy (45 Gy plus boost). Irradiated patients were randomized concerning the type of fractionation in either conventional fractionation (once daily 1.8-2.0 Gy, break of chemotherapy) or hyperfractionated split-course irradiation simultaneously with the VACA/VAIA chemotherapy (twice daily 1.6 Gy, break of 12 days after 22.4 Gy and 44.8 Gy, total dose and ...

1995-07-15

203

The radiological accident in Tammiku

Purpose/Objective: With the advent of computed tomography and magnetic resonance imaging, the three dimensional representation of the patient anatomy has become an invaluable resource for better diagnosis and delineation of the target volume and sensitive structures in radiation therapy. Although the therapeutic linear accelerator industry has made available highly sophisticated equipment, the aggressiveness in dose prescription and delivery has to be complimented by accurate dose computation methods. We have adopted a convolution/superposition algorithm for the calculation of absolute dose that fully accounts for the external shape and internal structure of the patient for photon treatment radiotherapy. In this paper, we will discuss the principles of the convolution algorithm and we will show how the computed dose compares to clinically relevant treatment techniques. Materials and Methods: A computer controlled data ...

204

Long-term results in 144 localized Ewing's sarcoma patients treated with combined therapy

On 21 October 1994, three brothers entered a waste repository at Tammiku, Estonia, without authorization and removed a metal container enclosing a caesium-137 source. During the removal the source was dislodged and fell to the ground. One of the men picked up the source, placed it in his pocket and took it to his home in the nearby village of Kiisa. Very soon after entry into the repository he began to feel ill, and few hours later he began to vomit. The man was subsequently admitted to hospital with severe injuries to his leg and hip and died on 2 November 1994. The injury and subsequent death were not attributed to radiation exposure, and the source remained in the man's house with his wife and stepson and the boy's great-grandmother. The boy was hospitalized on 17 November with severe burns on his hands, and these were identified by a doctor as radiation induced. The authorities were alerted, and the Estonian Rescue Board recovered the ...

205

Gamma irradiation in the control of pathogenic bacteria in refrigerated ground chicken meat; Irradiacao gama no controle de bacterias patogenicas em carne de frango refrigerada

The results of 144 previously untreated cases of primary Ewing's sarcoma of bone are reported with a minimum follow-up of 5 years. This series was treated between 1972 and 1982 at Istituto Ortopedico Rizzoli with a combined therapy. The local control of the disease consisted of amputation (ten cases), resection followed by radiation therapy (35-45 Gy) (48 cases) and radiation therapy alone (40-60 Gy) (86 cases). Adjuvant chemotherapy, rigorously standardized, was performed according two different protocols: the first (85 cases treated in the period 1972-1978) consisted of vincristine (VCR) Adriamycin (doxorubicin) (ADM), and cyclophosphamide (EDX); the second (59 cases treated in the period 1979-1982) of VCR, ADM, EDX and dactinomycin (DACT). At a follow-up of 5 to 16 years (median, 9), 59 patients (41%) are continuously disease-free (CDF), 81 (56%) developed metastatic disease and/or local recurrence, and four (3%) had a second malignancy. ...

206

Concept of malignant significant factor and its applicability for and occupational exposures

This work evaluated the effect of gamma radiation on reducing the population of Staphylococcus aureus, Escherichia coli nd Salmonella typhimurium in ground chicken breast stored under refrigeration. The experiment included a control and 4 doses of gamma radiation ( 2.0, 4.0, 6.0 and 8.0 kGy) along with 5 periods of storage under refrigeration ( 1, 7 14, 21 and 28 days). Samples of ground chicken breast were inoculated with Staphylococcus aureus (ATCC 14458), Escherichia coli (ATCC 11105) and Salmonella typhimurium (ATCC 0626), irradiated at temperatures between 4 and 8 deg C and stored under refrigeration (5 deg C) for 28 days. The increased radiation dose and period of storage under refrigeration caused a reduction of Staphylococcus aureus, Escherichia coli and Salmonella typhimurium populations in the ground chicken breast. Mean radiation D values determined for Staphylococcus aureus and Escherichia ...

2000-09-01

207

Early and Late Bowel Complication Following Irradiation of Cancer of the Uterine Cervix-Whole Pelvis External Irradiation end High-Dose-Rate Interactively Irradiation

In the medical and occupational exposures, there is a tradition to use the genetically significant dose as an index of harm to the population although it only includes the genetical effects from ionizing radiations. A similar significant dose for somatic effects such as radiation leukemogenesis and carcinogenesis should be added to the genetically significant dose in order to approach an index of total harm to the population from medical and occupational exposures. For this purpose, leukemia and malignant significant factors were determined based on the induction of malignant diseases including leukemia for the atomic bombs in Hiroshima and Nagasaki and the life expectancy of individuals subject to medical examinations or treatments as well as radiation workers, taking account of the possibility of their deaths due to other diseases or accidents during a latent period of malignant diseases. The ...

1980-01-01

208

Second malignancies after treatment for Ewing's sarcoma

Cervix cancer is the most common female cancer in Korea. In spite of their relatively local invasive tendency, still 44% of patient will develop recurrent cancer This result suggests that more aggressive local treatment may increase the cure rate but increased complication risk also cannot be avoidable. Various institutions proposed different treatment regimen, but recommended dose were about 4500 cGy for whole pelvis and 8000 cGy at point A, even though they agreed that those doses may not be satisfactory for control of bulky disease. 96 cases of invasive cervical cancer, treated with postoperative or primary radiation therapy were analyzed to determine the complication rate and prognostic factor in our treatment regimen which is 500-1000 cGy higher than other institution. Mean follow up duration was 21 months. Symptomatic patients including mild but persistent abdominal discomfort was 46%, but only 1 ...

1989-06-01

209

The effect of a metal hip prosthesis on the radiation dose in therapeutic photon beam irradiations

Background: Some former retrospective studies have suggested that patients with Ewing's sarcoma might have a very high risk for developing secondary sarcomas if treated with radiotherapy. We have evaluated the risk of second malignancies (SM) in patients treated in the German Cooperative Ewing's Sarcoma Studies CESS 81 and CESS 86. Materials and methods: From January 1981 through June 1991, a total number of 674 patients was registered in the two multicentric Ewing's sarcoma trials CESS 81 (1981 through 1985) and CESS 86 (1986 through June 1991). The systemic treatment consisted in both studies of a four-drug-chemotherapy (VACA= vincristine, actinomycin D, cyclophosphamide and adriamycin; or VAIA= vincristine, actinomycin D, ifosfamide and adriamycin) and a total number of four courses, each lasting nine weeks, was recommended by the protocol. Local therapy was either complete surgery or surgery plus postoperative radiotherapy with 36-46Gy or definitive ...

210

Radiosurgery for metastatic brain tumors

Prostate and cervical cancer patients are often treated with external X-ray beams of bi-lateral incidence. Such treatment may incur some dose effect that cannot be predicted precisely in commercial treatment planning systems (TPS) for patients having undergone total hip replacement. This study performs a Monte Carlo (MC) simulation and an analytical calculation (convolution superposition algorithm which is implemented in ADAC TPS) of a 6 MV, 5x5 cm"2 X-ray beam incident into water with the existence of hip prosthesis, e.g. Ti6Al4V and CoCrMo alloy. The results indicate that ADAC TPS cannot precisely account for the scatter and backscatter radiation that a metal hip prosthesis causes. For percent depth dose (PDD) curves, the maximum underdosage of ADAC TPS up to 5 mm above the interface between dense material and water is 5%, 20% and 27% for PDD_B_o_n_e, PDD_T_i and PDD_C_o, respectively. The dose re-buildup, which occurs ...

2002-07-01

211

Radiation disinfestation of dried salted mackerel found on packaging, transporting and marketing. Part of a coordinated programme for radiation preservation of dried fish indigenous to Asia

Stereotactic radiosurgery (SRS) precisely delivers high-dose radiation to a small target (usually less than 3-4 cm in diameter), in a single session with steep dose-fall, employing various radiation methods. SRS provides good tumor control for small brain metastases from various primary cancers, with minimal untoward effects on surrounding normal brain. This excellent tumor control prevents neurological death and maintains good activity of daily life. Although surgery with whole-brain radiation therapy (WBRT) remains an important option for patients with a solitary brain metastasis, SRS with or without WBRT should be considered in patients with a limited number of small tumors and a good prognosis. Many reports, as well as both retrospective and prospective reviews, have shown WBRT before or after SRS to improve local control and reduce new distant lesion emergence. However, upfront WBRT does not improve survival. There are ...

2009-08-01

212

Comparison of the radiobiological effect of carbon ion beam therapy and conventional radiation therapy on cervical cancer

Studies were made on different types of packaging materials used for packing dried fish in the Philippines with a view to finding a suitable packaging material for irradiated dried fish. Among these packaging materials (polyethylene, cello/polyethylene, polyester/polyethylene, Kraft paper, polypropylene and interwoven polypropylene sacks), polyester/polyethylene laminate was the most resistant material against penetration by Dermestes carnivorous. No insect damage occurred on the dried fish packed in interwoven polypropylene lined with polyester/polyethylene laminate. The cost per sack of such packaging material having a capacity of 50-80 kg is US$ 0.50. The sack lined with polyester/polyethylene proved to be durable for surface transportation from Bacolod City to Manila (approx. 360 miles). Radiation treatment at 225 krad was effective against bacterial contamination but not effective in inhibiting mould growth. Raw fish soaked in 25% salt for ...

213

Molecular targeted treatment and radiation therapy for rectal cancer

Little clinical evidence has been provided to show the minimization of radiation resistance of tumors using high linear energy transfer radiation. We therefore investigated the radiobiological and molecular pathological aspects of carbon beam therapy. A total of 27 patients with squamous cell carcinoma (SCC) of the cervix were treated using a carbon beam and 50 control patients with SCC of the cervix using a photon beam. The expression of Ki-67, p53, and p27 proteins before radiotherapy and 5 and 15 days after therapy initiation were investigated using immunohistochemistry. Similar changes were observed in Ki-67 labeling index (LI) and p53 LI during carbon and photon beam therapies. However, for carbon beam therapy, the mean p27 LI significantly decreased from 25.2% before treatment to 18.6% on the 5th day after treatment initiation, followed by a significant increase to 36.1% on the 15th day. In ...

2008-09-01

214

Effects of postoperative adjuvant chemotherapy and radiotherapy on ovarian function in women undergoing treatment for soft tissue sarcoma

Background: EGFR (epidermal growth factor receptor) and VEGF (vascular endothelial growth factor) inhibitors confer clinical benefit in metastatic colorectal cancer when combined with chemotherapy. An emerging strategy to improve outcomes in rectal cancer is to integrate biologically active, targeted agents as triple therapy into chemoradiation protocols. Material and methods: cetuximab and bevacizumab have now been incorporated into phase I-II studies of preoperative chemoradiation therapy (CRT) for rectal cancer. The rationale of these combinations, early efficacy and toxicity data, and possible molecular predictors for tumor response are reviewed. Computerized bibliographic searches of Pubmed were supplemented with hand searches of reference lists and abstracts of ASCO and ASTRO meetings. Results: the combination of cetuximab and CRT can be safely applied without dose compromises of the respective treatment components. Disappointingly low rates of pathologic ...

2009-06-15

215

Effects of postoperative adjuvant chemotherapy and radiotherapy on ovarian function in women undergoing treatment for soft tissue sarcoma

Ovarian function was evaluated in 11 women 16 to 43 years of age at treatment who received doxorubicin, cyclophosphamide, and high doses of methotrexate with or without radiotherapy in adjuvant therapy of soft tissue sarcoma. Five women (16-33 yr old) who received chemotherapy alone or combined with radiotherapy only at sites distant from the ovaries (chest wall, thigh, and leg) had minimal menstrual irregularities or temporary cessation of menses during therapy; cyclic menses returned promptly after therapy. Gonadotropin levels (expressed as means +/- SD) (follicle-stimulating hormone (FSH), 10 +/- 15 mlU/ml; luteinizing hormone (LH), 10 +/- 4 mlU/ml) and 17 ..beta..-estradiol (E/sub 2/) levels (means +/- SD, 208 +/- 147 pg/ml) were normal. By contrast, 4 older women (ages 36-43 yr) who received similar treatment developd persistent amenorrhea with postmenopausal levels of gonadotropin (FSH, 109 +/- 29 mlU/ml; LH, 72 +/- 19 mlU/ml) and E/sub ...

1981-12-01

216

Dosimetric evaluation of multi-pattern spatially fractionated radiation therapy using a multi-leaf collimator and collapsed cone convolution superposition dose calculation algorithm

Ovarian function was evaluated in 11 women 16 to 43 years of age at treatment who received doxorubicin, cyclophosphamide, and high doses of methotrexate with or without radiotherapy in adjuvant therapy of soft tissue sarcoma. Five women (16-33 yr old) who received chemotherapy alone or combined with radiotherapy only at sites distant from the ovaries (chest wall, thigh, and leg) had minimal menstrual irregularities or temporary cessation of menses during therapy; cyclic menses returned promptly after therapy. Gonadotropin levels (expressed as means +/- SD (follicle-stimulating hormone (FSH), 10 +/- 5 mlU/ml; luteinizing hormone (LH), 10 +/- 4 mlU/ml) and 17 beta-estradiol (E2) levels (means +/- SD, 208 +/- 147 pg/ml) were normal. By contrast, 4 older women (ages 36-43 yr) who received similar treatment developed persistent amenorrhea with postmenopausal levels of gonadotropin (FSH, 108 +/- 29 mlU/ml; LH, 72 +/- 19 mlU/ml) and E2 (19 +/- 8 ...

1981-12-01

217

Potentially pathogenic free-living amoebae isolated from hospital wards with immunodeficient patients in Tehran, Iran

Purpose: In this paper, we present an alternative to the originally proposed technique for the delivery of spatially fractionated radiation therapy (GRID) using multi-leaf collimator (MLC) shaped fields. We employ the MLC to deliver various pattern GRID treatments to large solid tumors and dosimetrically characterize the GRID fields. Methods and materials: The GRID fields were created with different open to blocked area ratios and with variable separation between the openings using a MLC. GRID designs were introduced into the Pinnacle"3 treatment planning system, and the dose was calculated in a water phantom. Ionization chamber and film measurements using both Kodak EDR2 and Gafchromic EBT film were performed in a SolidWater phantom to determine the relative output of each GRID design as well as its spatial dosimetric characteristics. Results: Agreement within 5.0% was observed between the Pinnacle"3 predicted dose ...

2009-10-01

218

British Library Electronic Table of Contents (United Kingdom)

This study investigated the occurrence of free-living amoebae (FLA) in immunodeficiency wards of hospitals in Tehran, Iran. A total of 70 dust and biofilm samples from wards serving transplant, pediatric (malignancies), HIV, leukemia and oncology patients of five university hospitals were collected and examined for the presence of FLA using culturing and molecular approaches. Based on the morphology of the amoebae in plate cultures, primer sets were applied for molecular identification of Acanthamoeba, vahlkampfiid amoebae and Hartmannella. Out of 70 samples, 37 (52.9%) were positive for FLA. Acanthamoeba belonged to the T4 genotype was the most prevalent isolate. Presence of the T4 genotype on medical instruments, including an oxygen mask in an isolation room of an immunodeficiency pediat...

2011-01-01

219

In vitro and in vivo evaluation of [{sup 123}I]-VEGF{sub 165} as a potential tumor marker

Image-guided percutaneous cryotherapy for the management of gynecologic cancer metastases

One of the research challenges in oncology is to develop new biochemical methods for noninvasive tumor therapy evaluation to determine whether the chemotherapeutics is effective. Vascular endothelial growth factor (VEGF) was labeled with radioiodine and evaluated in vitro as well as in vivo, using A2058, a melanoma cell line overexpressing VEGFR-1 and -2. Saturation binding analysis with [{sup 125}I]-VEGF resulted in a K {sub d} of 0.1 nM. Internalization assays indicate the preserved ligand induced internalization and metabolization of the tracer. Biodistribution studies with [{sup 123}I]-VEGF in wild type and A2058 tumor-bearing athymic mice showed low background activity and a tumor to reference tissue ratio of maximum 6.12. These results suggest that [{sup 123}I]-VEGF is a potentially suitable tracer for tumor therapy evaluation.

2005-07-01

220

British Library Electronic Table of Contents (United Kingdom)

Objective To report the clinical response to image-guided percutaneous cryotherapy (IPC) for the palliative management of localized metastases in patients with gynecologic malignancies. Methods Institutional review board approval and patient consent were obtained. Gynecologic oncology patients were identified from our institution's cryotherapy database from August 2003 to August 2007. Cryotherapy was performed with 2.4?mm diameter probes (Endocare, Irvine, CA) with ultrasound or computerized tomography (CT) guidance under conscious sedation and local anesthesia. Follow-up was conducted by imaging studies and clinical encounters, using Response Evaluation Criteria in Solid Tumors (RECIST criteria). Results Twenty-eight ablation sessions were performed for 41 metastatic foci in 15 patients w...

2008-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

221

Evaluation of surgical gamma probes for sentinel node localisation in cervical and vulvar cancer

Antitumor activity of platinum(II) complexes with histamine and radioiodinated histamine in a transplantable murine adenocarcinoma model

Sentinel node (SN) scintigraphy for cervical and vulvar cancer guides the gynaecological oncologist in finding the metastatic lymph nodes during lymphadenectomy. The role of the surgical gamma probe in the sentinel node concept in gynaecological oncology is to localise (SN) both intra-operatively and transcutaneously. Intra-operative hand-held collimated gamma probes are increasingly used for detection of the sentinel lymph node. A comparative evaluation of handheld gamma probes: Neoprobe 1500, Europrobe, Gamma Finder, Gamma Ray Prospector GRP1 and GPR2 was performed using different detection methods. Laboratory tests were performed in which sensitivity, spatial resolution and angular sensitivity were evaluated. The results for each gamma probe were summarised and discussed. Awareness of a gamma probes capabilities and limitations should be considered in the appropriate selection of a device. (author)

222

Reaction of ions in radiation chemistry

Purpose: Antitumor activity of the dichloroplatinum(II)-histamine complexes labeled with I-125 or I-131 was investigated in a transplantable murine adenocarcinoma (MA) model. Methods: The tumor model was obtained in C3H/W female mice after subcutaneous inoculation of the tumor cells derived from the mice bearing a mammary tumor of spontaneous origin. Antitumor activities of the platinum-histamine complexes were investigated in three independent experiments, which differed in applied doses of preparations (PtCl{sub 2}Hist, PtCl{sub 2}[{sup 125}I]Hist, PtCl{sub 2}[{sup 131}I]Hist, PtCl{sub 2}Hist/PtCl{sub 2}[{sup 125}I]Hist and PtCl{sub 2}Hist/PtCl{sub 2}[{sup 131}I]Hist), treatment schedules as well as stages of the disease progress in the animals used. Experiment 1 included long-term, multidose treatment with low single doses (treatment duration 31-32 days; 8-10 doses of ca. 0.25{center_dot}MTD{sub Pt} each). Experiment 2 ...

2008-07-15

223

Radiation Safety and Nutrition

No abstract prepared

1998-01-01

224

Environmental Research Database

No further description is available

225

Animal Models for Radiation Injury, Protection and Therapy

The Simultaneous effect of gamma radiation on susceptibility of the cotton leaf worm Spodoptera Littoralis (Boisd.) to methomy

... radiation during clinical therapy and exposures due to radiation accidents or attacks, in which the doses are uncontrolled ... only be used off-label in victims of radiation accidents or attacks. The idea...

226

Study on the stability of the Maytenus aquifolium Martius chemical components submitted to ionizing radiation (X-ray and #gamma#)

The simultaneous effects of irradiating full grown pupae of Spodoptera Littoralis with doses 30 and 40 krad followed by topical treatment of adults with methomyl were studied. Gamma rays decreased the toxicity of methomyl against adult moths. The obtained LD_5_0 values for male moths emerging from unirradiated or irradiated pupae with 30 or 40 krad were 7, 9.93 and 10.33 u g/g. b.wt., respectively. F1 larvae (produced from unirradiated females mated to irradiated males) became more tolerant to methomyl by increasing radiation doses from 5 to 30 krad. The toxicity of methomyl to F1, F2 and F3 larvae (whose male parents had been irradiated in the pupal stage with 10 krad) was less than its toxicity to the larvae produced from unirradiated parents. F2 and F3 larvae were more tolerant to methomyl effect than the F1 larvae.

227

Radiation processing as a post-harvest quarantine control for raisins, dried figs and dried apricots

The interest for medicinal plants has raised again in the last decades, after overcoming a declination period caused by the advances in the researches and development of the synthetic drugs industries. This growing interest has been stimulated mainly by searching cheap and accessible alternative therapies. However, in order to have natural products based treatment in an efficient and safety way, it is necessary to guarantee the plant authenticity, finding adulterations and to assure a low level of microbiological contaminations to avoid damages to consumer's health. The decontamination method should be chosen for eliminating or reduce the microorganisms level without loss of the plant active constituents that would destroy its therapeutic action. At the present work, the possibility of using #gamma# and X electromagnetic radiations to sterilize a Brazilian medicinal plant (Maytenus aquifolium Martius, Celastraceae), which shows anti-ulcer ...

228

Production of wood plastic properties using gamma radiation as a polimerization agent

The commercially packed samples of raisins, dried figs and dried apricots were irradiated using doses in the range of 0.5-1.0 kGy for disinfestation and 0.5-5.0 kGy for sensory analysis with the dose rate ranging from 1.44 to 1.92 kGy/h. Pests on dried fruits were evaluated after 0, 1, 2 and 3 months of storage for irradiated dried figs and 1, 3, 6 and 12 months of storage for raisins and dried apricots. Sensory analysis of dried figs, dried apricots and raisins were carried out after 0, 1, 3, 6 and 12 months of storage. The results indicated that radiation processing at low doses (#approx#1.0 kGy) is an effective post-harvest treatment and quarantine control for these products with no adverse effects on sensory (marketing) attributes.

2006-03-01

229

Numerical simulations of industrial processes involving fluid dynamics, combustion and radiation

The properties of wood plastic composites (WPC) based on Pinus Radiata D. Don impregnated with methylmethacrylate and subsequently polymerized with gamma radiation were studied. Different systems of impregnation were utilized, in order to obtain partial and shell loads. The minimum irradiation dose uses was 16 kGy. The following tests were made to the material: static bending, compression strenght parallel to grain, hardness, sheer strength, toughness, water absorption, dimensional stability and flame propagation index. To evaluate the testing, the results of the samples were separated according final density in the ranges: R_1 = 429-483 kg/m3 (without treatment); R_2 = 500-650 kg/m3 and R3 = 651-850 kg/m3. In general, the best results were obtained for samples of high density. The most important results were achieved for dimensional stability, water absorption and hardness. (Author).

1984-01-01

230

Effect of gamma irradiation on the antimicrobial and free radical scavenging activities of Glycyrrhiza glabra root

Moving out of the scientific community research laboratories, computational fluid dynamics (CFD) software packages are now allowing industrials to analyse and optimize industrial processes involving the use of gases, liquids and even some two-phase fluids. Their attractiveness and their impact stems out from the opportunity they offer to bring insight into an existing unit, or even at the design stage, by displaying the spatial distribution of process relevant variables such as temperature, concentration. The filling of the spacing in between a two-layer window is a simple example. This new opportunity of visualisation is at times an unique way, when the process environment is an opaque one, such as liquid metal flowing into a tundish or when measurements of flows may be a long and tedious work, such as flows within water treatment basins. This environment we are to investigate in order to optimize can also be a harsh one, due to its high temperature level for ...

1997-12-31

231

ESR dosimetry of irradiated chicken legs and chicken eggs

The efficacy of gamma irradiation as a method of decontamination for food and herbal materials is well established. In the present study, Glycyrrhiza glabra roots were irradiated at doses 5, 10, 15, 20 and 25 kGy in a cobalt-60 irradiator. The irradiated and un-irradiated control samples were evaluated for phenolic contents, antimicrobial activities and DPPH scavenging properties. The result of the present study showed that radiation treatment up to 20 kGy does not affect the antifungal and antibacterial activity of the plant. While sample irradiated at 25 kGy does showed changes in the antibacterial activity against some selected pathogens. No significant differences in the phenolic contents were observed for control and samples irradiated at 5, 10 and 15 kGy radiation doses. However, phenolic contents increased in samples treated with 20 and 25 kGy doses. The DPPH scavenging activity significantly (p<0.05) increased in ...

2010-04-01

232

A Two-step Intensity-modulated Radiation Therapy Method for Nasopharyngeal Cancer: The Kinki University Experience

Ionising radiation induces stable free radicals in chicken bones and in the shell of chicken eggs which can be detected, by the electrons spin resonance (ESR) technique, well beyond the shelf-life of the food and can be used for dosimetry. The method usually adopted to evaluate ``a posteriori`` the dose given during the ionising radiation treatment of food, is the dose additive method. To assess the dose, the ESR signal amplitude of the irradiated food (bone or egg shell in the present case) is measured and then the dose-effect relationship is obtained by re-irradiating the sample with some additive doses (usually of 1 kGy). The dose-effect curve is back-extrapolated and the initial given dose determined. At the Istituto Superiore di Sanita (ISS), Rome, Italy, a research programme was approved two years ago aimed to, (1) study new methodological approaches for ESR dose assessment, and (2) analyse the factors which may ...

1996-12-31

233

British Library Electronic Table of Contents (United Kingdom)

Objective The aim of this study was to analyze the clinical results of our adaptive radiation therapy scheme of a two-step intensity-modulated radiotherapy (IMRT) method for nasopharyngeal cancer (NPC) at Kinki University Hospital. Methods Between 2000 and 2007, 35 patients with Stage I-IVB NPC treated by IMRT were included. For all patients, treatment-planning computed tomography was done twice before and during IMRT to a total dose of 60-70 Gy/28-35 fractions (median 68 Gy). Chemotherapy (cisplatin 80 mg/m2/3 weeks x 1-3 courses) was given concurrently with IMRT for 31 patients. Results The 3- and 5-year overall survival rates for the 31 patients treated with concurrent chemotherapy were 88% and 83%, respectively. The 3- and 5-year loco-regional control rates for the 31 patients were 93%...

2010-01-01

234

The preparation of highly absorbing cellulosic copolymers -the cellulose acetate/propionate-g. co-acrylic acid system

Process development for remote-handled mixed-waste treatment

A series of copolymers based on the cellulose acetate/propionate-g.co-acrylic acid system has been prepared under radiation-induced control. These copolymers have been assessed for their water-retention capacity both in an unmodified state and after ''decrystallization'' or ''neutralization'' treatments. The grafting of acrylic acid onto the cellulose acetate/propionate had little effect on the water retention power of the cellulose acetate/propionate. However, improvements to the water retentivity was obtained after ''decrystallization'' procedures had been carried out on the copolymers using selected alkali metal salts with methanol as the continuous medium. The water-retentivity of the copolymers increased with increase in the extent of grafting, though the effect is less pronounced at high graft levels. Neutralization of the ...

1990-01-01

235

Cytotoxic effects of WR-2721 on mouse testicular cells

The Oak Ridge National Laboratory (ORNL) is developing a treatment process for remote-handled (RH) liquid transuranic mixed waste governed by the concept of minimizing the volume of waste requiring disposal. This task is to be accomplished by decontaminating the bulk components so the process effluent can be disposed with less risk and expense. Practical processes have been demonstrated on the laboratory scale for removing cesium 137 and strontium 90 isotopes from the waste, generating a concentrated waste volume, and rendering the bulk of the waste nearly radiation free for downstream processing. The process is projected to give decontamination factors of 10{sup 4} for cesium and 10{sup 3} for strontium. Because of the extent of decontamination, downstream processing will be contact handled. The transuranic, radioactive fraction of the mixed waste stream will be solidified using a thin-film evaporator and/or microwave solidification system. ...

1990-01-01

236

New placement of TIPS during pregnancy for recurring esophageal variceal bleeding: Estimation of fetal radiation exposure; TIPS-Neuanlage in der Schwangerschaft bei rezidivierender Oesophagusvarizenblutung - Abschaetzung der fetalen Strahlenexposition

WR-2721 (S-2-(3-aminopropylamino)ethylphosphorothioic acid) has been demonstrated to be cytotoxic to stem spermatogonia in the mouse. Five and 10 injections of 300 mg/kg killed sufficient numbers of stem cells to reduce sperm production 56 days after treatment by 16 and 43%, respectively. Single injections of 300 or 400 mg/kg of WR-2721 given 15 min after irradiation produced negligible toxicity to stem cells as measured by counts of repopulated tubules; 600 mg/kg reduced stem cell survival by 47%. Four daily injections of 300 mg/kg given 4, 3, 2, and 1 days prior to irradiation reduced stem cell survival by about 60%. The cytotoxic effects of WR-2721 on testicular stem cells at least partially explains the reduced protection factors observed in the testis with low doses of radiation and during fractionated treatments involving multiple injections of drug.

1984-09-01

237

Metabolic effects of microwave radiation and convection heating on human mononuclear leukocytes. Final report, January 1985-May 1986

Recurrent variceal bleeding due to liver cirrhosis led to treatment with a transjugular intrahepatic portosystemic shunt (TIPS) in a pregnant woman at 20 weeks` gestation. Fetal radiation exposure was estimated to be less than 10 mSv. The use of a graduated catheter allowed measurement of field size and reliable determination of the patient`s entrance dose. Radiation exposure of an approximated fetal dosage of 5.2 mSv did not justify abortion for medical reasons. Therefore, TIPS procedure is not generally contraindicated during pregnancy itself. TIPS placement may be a therapeutic option related to the severity of the underlying maternal disease, after radiation exposure of the fetus has been estimated. (orig.) [Deutsch] Bei rezidivierender Oesophagusvarizenblutung auf dem Boden einer Leberzirrhose wurde bei bestehender Schwangerschaft der 20. Woche ein transjugulaerer portosystemischer Stent-Shunt ...

1998-10-01

238

[Study of body composition by potassium-40 measurement in patients with breast and uterine cancer].

Investigated here were the effects of microwave (MW) radiation (2450-MHz, continuous-wave, mean specific absorption rate of 103.5 + or - 4.2 W/kg) and convention heating on the nonphosphorylating oxidative metabolism of human peripheral mononuclear leukocytes (96% lymphocytes, 4% monocytes) at 37 C. Metabolic activity, determined by chemiluminescence (CL) of cells challenged with luminol (5-aminO-2, 3-dihydro-1, 4-phthalazinedione) linked to bovine serum albumin, was detected with a brightness photomer. A significant stimulation after after MW exposure (p < 0.005) over total CL of matched 37 C-incubator controls was observed. A similar degree of stimulation, compared to incubator controls, was also detected after sham treatment. No significant difference existed between changes in total CL or stimulation indices of the MW and sham-exposed groups. Exposure to MW radiation, under normothermic (37 + or - 0.03 C) conditions, ...

1986-01-01

239

The prooxidant-antioxidant homeostasis in Guinea pigs after exposure to fractionated low-low X-radiation and correction of its disturbances with antioxidant complex treatment

Total potassium was assayed in 150 normal weight and obese females (cervical carcinoma-52, endometrial carcinoma-25 and breast cancer-73) by measurements of 40K spontaneous radiation in a low-background chamber. Control group included 30 healthy and 25 obese females. Computations of body cell and extracellular mass and fat were carried out on the basis of the said measurements. Extracellular fluid volume was measured in 38 patients by X-ray fluorescence method using sodium bromide. The results pointed to a body cell mass deficit matched by increased extracellular mass due to a higher fat level in patients with breast, endometrial and cervical carcinoma. The said correlation was particularly pronounced in obese patients. The beneficial effect of treatment was more often observed in patients with normal body weight. PMID:3739295

1986-01-01

240

Synthesis of metallic nanoparticles in SiO{sub 2} matrices; Sintesis de nanoparticulas metalicas en matrices de SiO{sub 2}

The state of prooxidant-antioxidant homeostasis in Guinea pigs exposed to whole-body fractionated X-irradiation (5 fractions of 0.2 Gy at a 24 hr interval, up to total dose of 1.0 Gy, at a dose rate of 0.425 R/min) and a possibility of its disturbance correction with the complex of vitamins C, E and P was studied. Accumulation of primary and secondary lipid peroxidation products, decrease of the ascorbic acid content, increase of the content of its oxidized forms (dehydroascorbic acid and diketogulonic acid) in radiosensitive and radioresistant organs were found. Antioxidant complex administration reduced the disturbances of prooxidant-antioxidant homeostasis, but did not provide complete normalization.

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

241

Radiation processing of fibre-reinforced composites

Metallic nanoparticles was synthesized in SiO{sub 2} matrices by means of a process of two stages. The first one proceeded via sol-gel, incorporating the metallic precursors to the reaction system before the solidification of the matrix. Later on, the samples underwent a thermal treatment in atmosphere of H{sub 2}, carrying out the reduction of the metals that finally formed to the nanoparticles. Then it was detected the presence of smaller nanoparticles than 20 nm, dispersed and with the property of being liberated easily of the matrix, conserving a free surface, chemically reactive and with response to external electromagnetic radiation. The system SiO{sub 2}-Pd showed an important thermoluminescent response. (Author)

2004-07-01

242

Prevention of death from ingested ruthenium-106 by colectomy

Electron beam (EB) processing involves using electrons to initiate polymerization or cross-linking reactions in suitable substrates, thereby enhancing specific physical and chemical properties. A relatively new use of EB processing is now emerging: the production of fibre-reinforced composites. EB curing at ambient temperature has the potential to reduce the residual stresses in an advanced composite, a result of expansion during thermal curing, and to significantly increase the overall cure speed and process throughput. Wood fibres are used as a filler material for various thermoplastics such as polypropylene. EB treatment, combined with selected EB-curable coupling agents, significantly increases the adhesion between the wood fibres and the thermoplastic polymer, resulting in improved material properties. Work to develop both products and processes for the EB curing of fibre-reinforced composites is currently underway at AECL Research. This paper briefly updates ...

1991-06-09

243

Preparation and dosimetry of radiotherapeutic particles for arthropaties; Preparacion y dosimetria de particulas radioterapeuticas para artropatias

Two dogs were given 3.0 mCi/kg body weight of "1"0"6Ru-"1"0"6Rh and two were given 4.0 mCi/kg. At 5 days after treatment, one dog from each dose level was colectomized. The dog given the larger dose but not surgically treated was killed in extremis due to acute lower bowel injury at 18 days. The other dog, given 3.0 mCi/kg but not surgically treated, was killed in a moribund condition at 145 days after dosing. The rectum had perforated. The colectomized dogs recovered from intestinal injury and showed no radiation damage at the termination of the study.

1977-05-01

244

Packing for food irradiation

It was developed a new formulation of macro aggregates of Samarium 153 ({sup 153} Sm-MH) for the arthropaties treatment. The radio pharmaceutic was prepared by reaction of Samarium 153 chloride (SmCl{sub 3}) in aqueous environment with sodium boron hydride in NaOH 0.5 N. The microscopic analysis shown that the particles have an average size of 4% m (range 1-14 {mu} m). The velocity of sedimentation was 0.008 cm/min with high stability in vitro in human serum. The biological studies in healthy rabbits, shown that the complex is retained inside the articulation still eight days after of the administration of the radiopharmaceutical. Likewise, it is presented the data of absorbed dose in the different target organs, which was determined by thermoluminescent dosimetry (TLD) through the use of a REMCAL phantom (radiation equivalent manikin calibration). (Author)

1999-07-01

245

Automated preparation of Re-188 lipiodol for the treatment of hepatocellular carcinoma

Joint FAO/IAEA/WHO Expert Committee approved the use of radiation treatment of foods. Nowadays food packaging are mostly made of plastics, natural or synthetic, therefore effect of irradiation on these materials is crucial for packing engineering for food irradiation technology. By selecting the right polymer materials for food packaging it can be ensured that the critical elements of material and product performance are not compromised. When packaging materials are in contact with food at the time of irradiation that regulatory approvals sometimes apply. The review of the R-and-D and technical papers regarding material selection, testing and approval is presented in the report. The most information come from the USA where this subject is well elaborated, the International Atomic Energy Agency (IAEA) reports are reviewed as well. The report can be useful for scientists and food irradiation plants operators. (author)

246

Adaptive Radiation Therapy for Localized Mesothelioma with Mediastinal Metastasis Using Helical Tomotherapy

The iodinated oil lipiodol is commonly used as a carrier for in situ delivery of drugs or radioactivity to hepatic tumors. Recently, we reported a new kit formulation for high-activity labeling of lipiodol with the {beta}-emitting radionuclide Re-188. Since the whole preparation involves different steps and complex manipulations of high-activity samples, we describe here an automated synthesis module that allows the easy preparation of sterile and pyrogen-free samples of Re-188 lipiodol ready to be administered to the patient. Important advantages include the possibility to incorporate high Re-188 activity into the lipiodol hydrophobic phase and a sharp reduction of radiation exposure of the operator assisting the labelling procedure. Application of this modular reaction system could be also extended to the preparation of other Re-188 radiopharmaceuticals and to compound labelled with different {beta}-emitting therapeutic radionuclides.

2011-02-15

247

British Library Electronic Table of Contents (United Kingdom)

The purpose of this study was to compare 2 adaptive radiotherapy strategies with helical tomotherapy. A patient having mesothelioma with mediastinal nodes was treated using helical tomotherapy with pretreatment megavoltage CT (MVCT) imaging. Gross tumor volumes (GTVs) were outlined on every MVCT study. Two alternatives for adapting the treatment were investigated: (1) keeping the prescribed dose to the targets while reducing the dose to the OARs and (2) escalating the target dose while maintaining the original level of healthy tissue sparing. Intensity modulated radiotherapy (step-and-shoot IMRT) and 3D conformal radiotherapy (3DCRT) plans for the patient were generated and compared. The primary lesion and nodal mass regressed by 16.2% and 32.5%, respectively. Adapted GTVs and reduced plan...

2009-01-01

248

Radiation therapy for gastrointestinal lymphomas: indications and techniques

Lung dose calculations at kilovoltage x-ray energies using a model-based treatment planning system

Gastrointestinal lymphomas are almost exclusively of a non Hodgkin's type. The Western form is characterized by a higher incidence of stomach location (50 %), a MALT type (mucosa associated lymphoid tissue) (40 %), a B-cell type (90 %), and a high grade (55 %). Chronic infection with Helicobacter pylori is an important risk factor. Mediterranean lymphomas form a particular clinical and pathological entity with diffuse involvement of the small bowel and are frequently being associated with a chronic malabsorption disorder. Eradication of Helicobacter pylori in early lymphomas, and the use of tetracyclines in early Mediterranean lymphomas, have been shown to induce durable remissions. For more advanced gastric lymphomas, treatment usually consists of anthracycline-based chemotherapy followed by involved field radiotherapy. Surgery is usually reserved for complications such as perforation or bleeding, or in some selected cases for salvage after failure of non-surgical ...

249

Long-term results following multidisciplinary treatment of localized Ewing's sarcoma in children and adolescents

The determination of the dose to organs from diagnostic x rays has become important because of reports of radiation injury to patients from fluoroscopically guided interventional procedures. We have modified a convolution/superposition-based treatment planning system to compute the dose distribution for kilovoltage beams. We computed lung doses using this system and compared them to those calculated using the CDI3 organ dose calculation program. We also computed average lung doses from a simulated radiofrequency ablation procedure and compared our results to published doses for a similar procedure. Doses calculated using this system were an average of 20% lower for AP beams and 7% higher for PA beams than those obtained using CDI3. The ratio of the average dose to the lungs to the skin dose from the simulated ablation procedure ranged from 25% higher to 15% lower than that determined by other authors. Our results show that a ...

2001-02-01

250

Heat Shock Protein 27-Targeted Heptapeptide of the PKC? Catalytic V5 Region Sensitizes Tumors With Radio- and Chemoresistance

Purpose: To identify results and prognostic factors on long-term survival and local control following treatment of localized Ewing's sarcoma. Patients and Methods: Between 1979 and 2004, a total of 60 children and young adults with Ewing's sarcoma were treated. Patients with distant metastases at presentation (n = 6) and recurrent cases (n = 2) were excluded from this analysis. Patients were exclusively treated within ongoing national and international protocols CESS-81, CESS-86, EICESS-92, EURO-EWING-99. All patients received local irradiation with a total dose of 45-60 Gy; in addition, 41 (79%) of the patients had local surgical procedures, 27 (52%) of them with clear margins. Results: Overall survival rates at 5 and 10 years were 56% and 45%, respectively. Patients #<=# 14 years at diagnosis had overall survival rates of 66% and 61% at 5 and 10 years compared to older patients with corresponding survival rates of 47% and 31%, respectively (p = 0.05). Patients ...

2008-03-01

251

Bacterial radiosensitization by using radiation processing in combination with essential oil: Mechanism of action

Purpose: Previous data suggest that the PKC? catalytic V5 (PKC?-V5) heptapeptide (HEPT) (FEQFLDI) binds HSP27 and blocks HSP27-mediated radio- or chemoresistance. Here we investigated further the in vivo function of the PKC?-V5 HEPT. Methods and Materials: Labeling of HEPT with Cy5.5 or fluorescein isothiocyanate was performed to evaluate in vitro or in vivo distribution of HEPT. A clonogenic survival assay, flow cytometry, and Western blotting of cleaved caspase-3 were performed to determine in vitro sensitization effects of HEPT plus ionizing radiation (IR) versus IR alone or those of HEPT plus cisplatin(Cis) versus Cis alone. A nude mouse xenografting system was also applied to detect in vivo sensitizing effects of HEPT. Results: HEPT efficiently bound to HSP27 and showed sensitization after combined treatment with IR versus treatment with Cis alone in NCI-H1299 lung carcinoma cells, with higher HSP27 expression, which ...

2011-05-01

252

Effect of gamma radiation in the conservation of minimally processed cassava-parsley (Arracacia xanthorrhiza Bancroft) packed under vacuous

Spice extracts under the form of essential oils were tested for their efficiency to increase the relative radiosensitivity of Listeria monocytogenes and Escherichia coli O157H7 in culture media. The two pathogens were treated by gamma-irradiation alone or in combination with oregano essential oil to evaluate their mechanism of action. The membrane murein composition, and the intracellular and extracellular concentration of ATP was determined. The bacterial strains were treated with two irradiation doses: 1.2 kGy to induce cell damage and 3.5 kGy to cause cell death for L. monocytogenes. A dose of 0.4 kGy to induce cell damages, 1.1 kGy to obtain viable but nonculturable (VBNC) state and 1.3 kGy to obtain a lethal dose was also applied on E. coli O157H7. Oregano essential oil was used at 0.020% and 0.025% (w/v), which is the minimum inhibitory concentration (MIC) for L. monocytogenes. For E. coli O157H7, a concentration of 0.006% and 0.025% (w/v) which is the minimum inhibitory ...

2009-07-15

253

Statistical cut-off criterion

In the third millennium, when the main words are globalization, world net of computers, genetic code and efficiency, deep transformations have been incorporated to human behavior. Among such transformations it may be pointed out, matching with the objectives of this study, the modem consumer's profile. The consumers have quickly become more and more conscious and demanding regarding to the quality of the available products in the market. In that sense, the consumer's concern about the natural and healthy appearance, as well as the preservation of the nutritious content of the foods, have been a constant sign of alert for producers and suppliers. Besides, the timeless for domestic preparation of foods have imposed the use of minimally processed as an incontestable reality. A barrier for the production of minimally processed foods is imposed by the degree of perishability of certain products, such as the cassava-parsley. This vegetable is a source of energy, calcium, phosphorus and ...

254

Radiation protection and the management of radioactive waste in the oil and gas industry

... radiation effects human populations low dose irradiation neoplasms radiation

1980-01-01

255

Influence of germanium and oxygen impurities on the radiation hardening of monocrystalline silicon

Radiation protection and the management of radioactive waste in the oil and gas industry

2003-01-01

256

Higher harmonics of spontaneous radiation of ultrarelativistic channeled particles

... defects doped materials germanium infrared radiation monocrystals neutron

257

Genetically and somatically significant radiation doses in the radiotherapy of inflammatory and degenerative diseases

The case of spontaneous radiation of channeled ultrarelativistic particles is considered when the dipolarity condition is not satisfied. The change of the particle longitudinal velocity affecting the maximum radiation frequency is included. The angular and frequency characteristics of the radiation for superhigh energies are studied for the first time. It is shown that there is an optimum energy at which the radiation density is maximum. The influence of the angle at which electrons enter a crystal and of the beam divergence on the radiation is investigated. The problem of quasichanneled particle radiation and also the radiation in axis-plane transitions are considered. (author).

1980-06-01

258

Contribution to the radiation preparation of wood-plastic materials. Pt. 7

... pathological changes patients radiation protection radiotherapy diseases

1982-10-25

259

Contribution to the radiation preparation of wood-plastic materials. Pt. 6

... odd nuclei organic compounds radiation effects radioisotopes synthesis

1974-01-01

260

Contribution to the radiation preparation of wood-plastic materials Pt. 3

... compounds polymers polyolefins polyvinyls radiation effects SYNTHESIS.

1974-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

261

Compact Proton and Carbon Ion Synchrotrons for Radiation Therapy

... compounds plants radiation effects radioisotopes reaction kinetics trees

1974-01-01

262

Compact Proton and Carbon Ion Synchrotrons for Radiation Therapy

2002-01-01

263

? j -

Sequence analysis of the ATM gene in 20 patients with RTOG grade 3 or 4 acute and/or late tissue radiation side effects

duced and spontaneous radiation. The amount of polarization is ... of the induced and spontaneous radiation patterns. Therefore ...

264

Radiation therapy in the multimodal management of Ewing's sarcoma of bone: report of the Intergroup Ewing's Sarcoma Study

Purpose: Patients with ataxia-telangiectasia (A-T) show greatly increased radiation sensitivity and cancer predisposition. Family studies imply that the otherwise clinically silent heterozygotes of this autosomal recessive disease run a 3.5 to 3.8 higher risk of developing cancer. In vitro studies suggest moderately increased cellular radiation sensitivity of A-T carriers. They may also show elevated clinical radiosensitivity. We retrospectively examined patients who presented with severe adverse reactions during or after standard radiation treatment for mutations in the gene responsible for A-T, ATM, considering a potential means of future identification of radiosensitive individuals prospectively to adjust dosage schedules. Material and Methods: We selected 20 cancer patients (breast, 11; rectum, 2; ENT, 2; bladder, 1; prostate, 1; anus, 1; astrocytoma, 1; Hodgkins lymphoma, 1) with Grade 3 to 4 ...

1999-07-15

265

Biokinetic and dosimetric studies of {sup 188}Re-hyaluronic acid: a new radiopharmaceutical for treatment of hepatocellular carcinoma

This paper is a progress report on the role of radiation therapy (RT) in local tumor control and the decreased incidence of pulmonary metastasis in 251 patients entered in the Intergroup Ewing's Sarcoma Study. All were followed for more that 1 year, and their RT records were reviewed. Doses to the primary tumor in the range of 4,500--6,500 rad were administered over approximately 5 to 6 weeks in combination with 4 drugs, i.e., vincristine (VCR), dactinomycin (DAC), cyclophosphamide (CY), and adriamycin, or only the first 3. One group of patients received the 3 drugs and bilateral pulmonary irradiation (approximately 1,500 rad in 2 wk). Preliminary analysis showed a local primary tumor control of approximately 90%. Patients with lesions in the pelvis and humerus had local failure rates of 13% (7 of 54) and 21.4% (6 of 28), respectively. The treatment groups differed significantly in the incidence of pulmonary metastasis. Patients treated with ...

266

Systematics of average radiative width of heavy nuclides

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and has very limited therapeutic options. Recently, it has been found that hyaluronic acid (HA) shows selective binding to CD44 receptors expressed in most cancer histotypes. Since the trend in cancer treatment is the use of targeted radionuclide therapy, the aim of this research was to label HA with rhenium-188 and to evaluate its potential use as a hepatocarcinoma therapeutic radiopharmaceutical. Methods: {sup 188}Re-HA was prepared by a direct labelling method to produce a ReO(O-COO){sub 2}-type coordination complex. {sup 188}Re-HA protein binding and its stability in saline, phosphate buffer, human serum and cysteine solutions were determined. Biokinetic and dosimetric data were estimated in healthy mice (n=60) using the Medical Internal Radiation Dose methodology and mouse model beta-absorbed fractions. To evaluate liver toxicity, alanine aminotranferase (AST) and ...

2009-08-15

267

Pilot Study of the Treatment of VEGF-Signaling Pathway Inhibitor-Induced Hypertension

Systematics of neutron capture radiative width were studied in the target element range from Th to Cm. Reduced radiative widths were analyzed with a simple radiative width formula based on E1 transition. Average radiative width is presented with the standard deviation of 15%. (author)

1999-03-01

268

Acute treatment of inversion ankle sprains: immobilization versus functional treatment.

Treatment Induced Hypertension

2011-01-19

269

Development of a computerized portal verification scheme for pelvic treatment fields

PMID:17912059

2007-10-01

270

A multi-disciplinary study investigating radiotherapy in Ewing's sarcoma - a final report of POG 8346

Purpose/Objective: At present, treatment verification between portal and reference images is performed based on manually-identified features by radiation oncologist, which is both time-consuming and potentially error-prone. There is a demand for the computerized verification procedure in clinical application. The purpose of this study is to develop a computerized portal verification scheme for pelvic treatment fields. Materials/Methods: The automated verification system involves image acquisition, image feature extraction, feature matching between reference and portal images and quantitative evaluation of patient setup. Electronic portal images with a matrix size of 256 x 256 and 12 bit gray levels were acquired using a liquid matrix electronic portal imaging device. Simulation images were acquired by digitizing simulation films using a TV camera into images with 256 x 256 matrix and 8 bit gray levels. Initially a Canny ...

1996-09-01

271

Incorporating an improved dose-calculation algorithm in conformal radiotherapy of lung cancer: re-evaluation of dose in normal lung tissue

Purpose: To determine if involved field radiation (IF) is equivalent to standard whole bone radiation (SF) in local tumor control; to establish patterns of failure following treatment; and to determine response, event free (EFS) and overall survival rates from multi-disciplinary therapy in Ewing's Sarcoma (ES). Materials and Methods: Between 1983 and 1988, 184 children with ES were enrolled onto POG 8346. 178 (97%) met eligibility criteria; 6 had non-ES pathology. Induction treatment of Cyclophosphamide/Adriamycin (C/A) x 12 weeks was followed by local treatment either surgery or radiation therapy (XRT) and C/A, Dactinomycin and Vincristine for 50 weeks. Resection was advised for patients with small primary tumors if accomplished without functional loss. 40 patients were randomized to receive SF, whole bone XRT to 39.6 Gy plus a 16.2 Gy boost (total 55.8 Gy) or ...

272

The role of the HCR system in the repair of lethal lesions of Bacillus subtilis phages and their transfecting DNA damaged by radiation and alkylating agents

Background and purpose: The low density of lung tissue causes a reduced attenuation of photons and an increased range of secondary electrons, which is inaccurately predicted by the algorithms incorporated in some commonly available treatment planning systems (TPSs). This study evaluates the differences in dose in normal lung tissue computed using a simple and a more correct algorithm. We also studied the consequences of these differences on the dose-effect relations for radiation-induced lung injury. Materials and methods: The treatment plans of 68 lung cancer patients initially produced in a TPS using a calculation model that incorporates the equivalent-pathlength (EPL) inhomogeneity-correction algorithm, were recalculated in a TPS with the convolution-superposition (CS) algorithm. The higher accuracy of the CS algorithm is well-established. Dose distributions in lung were compared using isodoses, dose-volume histograms ...

2003-10-01

273

Punica granatum peel extract protects against ionizing radiation-induced enteritis and leukocyte apoptosis in rats

The role of the HCR system in the repair of prelethal lesions induced by UV light, #gamma# radiation and alkylating agents was studied in the Bacillus subtilis SPP1 phage, its heat sensitive mutants (N3, N73 nad ts_1) and corresponding infectious DNA. The survival of phages and their transfecting DNA after treatment with UV light is substantially higher in hcr"+ cells than in hcr cells, the differences being more striking in intact phages than in their transfecting DNA's. Repair inhibitors reduce survival in hcr"+ cells: caffeine lowers the survival of UV-irradiated phage SPP1 in exponentially growing hcr"+ cells but has no effect on its survival in competent hcr"+ cells; acriflavin and ethidium bromide decrease the survival of the UV-irradiated SPP1 phage in both exponentially growing and competent hcr"+ cells to the level of survival observed in hcr cells; moreover, ethidium bromide lowers the number of infective centres in hcr"+ cells of the ...

274

Induction and use of sex linked lethal mutations in the pink bollworm

Radiation-induced enteritis is a well-recognized sequel of therapeutic irradiation. Therefore we examined the radioprotective properties of Punica granatum peel extract (PPE) on the oxidative damage in the ileum. Rats were exposed to a single whole-body X-ray irradiation of 800 cGy. Irradiated rats were pretreated orally with saline or PPE (50 mg/kg/day) for 10 days before irradiation and the following 10 days, while control rats received saline or PPE but no irradiation. Then plasma and ileum samples were obtained. Irradiation caused a decrease in glutathione and total antioxidant capacity, which was accompanied by increases in malondialdehyde levels, myeloperoxidase activity, collagen content of the tissue with a concomitant increase 8-hydroxy-2'-deoxyguanosine (an index of oxidative DNA damage). Similarly, pro-inflammatory cytokines (TNF-?, IL-1? and IL-6) and lactate dehydrogenase were elevated in irradiated groups as compared to control. PPE ...

2009-07-01

275

Electron beam intraoral cone therapy in carcinoma of tongue. Report of eight cases and review of the literature

The sterile insect release technique can often be improved by removal of females before release. Rearing efficiencies can also be increased if removal of the females occurs at early developmental stages. In order to begin to develop genetic sexing strains for the pink bollworm, Pectinophora gossypiella (Saunders), it was necessary to determine the best dosage of radiation for induction of viable sex linked recessive lethal mutations and to see if stocks containing induced sex linked lethals could be maintained in culture. Sex linked recessive lethal mutations can be detected by distorted sex ratios in the progeny of treated adults. However, in the pink bollworm, highly distorted sex ratios are common even in the absence of induced mutations. Therefore, a visible sex linked trait, purple eye, was used as a marker for the untreated X-chromosomes in crosses. Thus, the presence of a recessive sex linked lethal mutation induced by the radiation ...

1987-11-16

276

A detailed analysis of the properties of radiolyzed proteinaceous amino acids

The clinical results of electron beam therapy using intraoral cone in 8 cases of primary and recurrence carcinoma of tongue (T1 and smaller T2) were reported. The primary and recurrence cases were 5 and 3, respectively. In the 5 cases, a total dose of 10-30 Gy external radiation therapy were combined prior to electron beam therapy. The total dose of electron beam therapy varied from 40 to 60 Gy. In all cases, tumor showed good response and disappeared clinically. Radiation stomatitis, pain of the tongue with masticatory disturbance due to tenderness were complicated in all cases. These complications gradually disappeared 2 to 6 months after treatment. However, loss of body weight and bone exposure were not recognized in any case. Intraoral-cone electron beam therapy is thought to be available and has less complications comparing interstitial irradiation therapy from the review of literature. Within 6 months after ...

1989-06-01

277

Monte Carlo evaluation of the AAA treatment planning algorithm in a heterogeneous multilayer phantom and IMRT clinical treatments for an Elekta SL25 linear accelerator

The thermal behaviour of 21 proteinaceous l-amino acids either as pristine samples and also as radiolyzed (3.2 MGy) samples was studied with the differential scanning calorimeter. The onset and peak melting point as well as the melting enthalpy of all samples before and after the radiation treatment was measured and reported. The residual amount of each amino acid survived to the radiation dose of 3.2 MGy (N_#gamma#) was measured from the melting enthalpies before and after radiolysis and hence the radiation resistance of each amino acid has been determined. The radiolysis causes a systematic reduction of the melting enthalpy and a shift of the onset and peak melting point to lower values. It is shown that N_#gamma# does not correlate with the melting points of the amino acids but shows a correlation with the entity of the shift of the melting point peaks occurred after radiolysis. Such correlation ...

2011-03-01

278

Hyperthermia in the Treatment of Cholangiocarcinoma: Development and Testing of an Endobiliary Microwave Device

The Anisotropic Analytical Algorithm (AAA) is a new pencil beam convolution/superposition algorithm proposed by Varian for photon dose calculations. The configuration of AAA depends on linear accelerator design and specifications. The purpose of this study was to investigate the accuracy of AAA for an Elekta SL25 linear accelerator for small fields and intensity modulated radiation therapy (IMRT) treatments in inhomogeneous media. The accuracy of AAA was evaluated in two studies. First, AAA was compared both with Monte Carlo (MC) and the measurements in an inhomogeneous phantom simulating lung equivalent tissues and bone ribs. The algorithm was tested under lateral electronic disequilibrium conditions, using small fields (2x2 cm"2). Good agreement was generally achieved for depth dose and profiles, with deviations generally below 3% in lung inhomogeneities and below 5% at interfaces. However, the effects of attenuation and scattering close to ...

2007-05-01

279

Dose verification using a pelvic phantom in high dose rate (HDR) brachytherapy

Purpose: The aim of this study was to create, perfect and test a hyperthermia balloon catheter for local treatment of cholangiocarcinoma. The device should induce hyperthermia in tumor tissue by acting locally in the bile duct lumen in contact with the tumor-infiltrated duct wall. In addition, it should exert tissue compression to cause an appreciable reduction in tumor microvasculature flow, thus improving thermal performance. Methods: According to the design specifications, the working temperature range should allow the device to be used for hyperthermia therapy either in combination with radiation and/or chemotherapy(radio/chemo-sensitizing effect at 42-45 deg. C) or alone (induction of coagulation necrosis above 65 deg. C). The balloon serves as an anchoring system during treatment and as a functional element to induce tissue compression. In vitro mechanical evaluation of the pressure/volume relationship, with the ...

2003-08-01

280

Can simulation measurements be used to predict the irradiated lung volume in the tangential fields in patients treated for breast cancer

High dose rate (HDR) brachytherapy for treating a cervix carcinoma has become popular, because it eliminates many of the problems associated with conventional brachytherapy. In order to improve the clinical effectiveness with HDR brachytherapy, a dose calculation algorithm, optimization procedures, and image registrations need to be verified by comparing the dose distributions from a planning computer and those from a humanoid phantom. In this study, the humanoid phantom was fabricated in order to verify the absolute doses and the relative dose distributions. The measured doses from the humanoid phantom were then compared with the treatment planning system for the dose verification. The humanoid phantom needs to be designed such that the dose distributions can be quantitatively evaluated thermoluminescent dosimeter (TLD) chips with a dimension of 1/8 and film dosimetry with a spatial resolution of <1 mm used to measure the radiation ...

2003-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

281

Development of internal dose estimation software on radiation protection

A simple method of estimating the amount of lung irradiated in patients with breast cancer would be of use in minimizing lung complications. To determine whether simple measurements taken at the time of simulation can be used to predict the lung volume in the radiation field, we performed CT scans as part of treatment planning in 40 cases undergoing radiotherapy for breast cancer. Parameters measured from simulator films included: (a) the perpendicular distance from the posterior tangential field edge to the posterior part of the anterior chest wall at the center of the field (CLD); (b) the maximum perpendicular distance from the posterior tangential field edge to the posterior part of the anterior chest wall (MLD); and (c) the length of lung (L) as measured at the posterior tangential field edge on the simulator film. CT scans of the chest were performed with the patient in the treatment position with 1 cm slice intervals, ...

1990-01-01

282

The evaluation of risks from radiation

Objective: To develop a computerized method of internal dose estimation on radiation protection. Methods: Based on MIRD mathematic model of the organs and by means of the programming language of MS Visual Basic 6.0, a computer program of dose estimation in internal radiation was developed for radiation protection. Results: The computerized method of dose estimation for internal radiation was completed. Conclusions: This computerized method is very convenient for internal radiation dose estimation of several aspects. It can also be used in radiation accident. (authors)

2008-10-01

283

Study of Maytenus aquifolium martius chemical compounds stability face to ionizing radiations (x radiation and gamma radiation)

German translation of the publication 'The evaluation of risks from radiation' published in 1965 by the International Commission on Radiological Protection. In a survey, genetic and somatic risks from radiation are presented and explained. (HP).

1977-01-01

284

Role of Mast Cells in Early and Delayed Radiation Injury in Rat Intestine

Portuguese Sep-Oct 1996 p. 571 Brazil Campos, Patricia Sao Paulo

285

Radionuclide X-ray fluorescence analysis. 1: Excitation of X-ray fluorescense radiation by nuclear radiation

... mast cell staining; ref. 16). The severity of structural radiation injury was assessed using a histopathological radiation injury score ... ...

286

Radionuclide X-ray fluorescence analysis. 2: Detection of the X-ray fluorescence radiation excited by radionuclide radiation

The principles of radionuclide excitation of X-ray fluorescence radiation and its application in

1972-01-01

287

Radiation protection - an overview of the concept for radiation protection at work and the concept for environmental radiation protection

This investigation describes the technique for the detection of the X-ray fluorescent radiation

1972-01-01

288

A versatile and potentially general approach to the targeting of specific cell types by retroviruses: Application to the infection of human cells by means of major histocompatibility complex class I and class II antigens by mouse ecotropic murine leukemia virus-derived viruses

This book gives an overview of the entire field of radiation protection with the subject areas radioactivity, X-rays, UV radiation, laser beams and high-frequency electromagnetic fields. It deals graphically with the most important physical notions, the incidence, origin, properties and biological effects of types of radiation, administrative and practical protection measures and the code of rules governing them. Apart from fundamentals of radiation protection the emphasis on the following: natural radiation exposure, radiation exposure to radon, disaster relief plans in the environment of nuclear plant, the precautionary radiation protection system evolved after Chernobyl, radiation exposure through UV radiation devices, radio, RF communication, radar, microwave ovens and high-voltage transmission ...

1993-01-01

289

New procedures. Comprehensive staging of lung cancer by MRI; Neue Verfahren. Umfassendes Staging des Lungenkarzinoms mit der MRT

A technique for delivering genes carried by recombinant retroviruses into specific cell types could have numerous applications in oncology, developmental biology, and gene therapy. As a first step toward this remote goal the authors designed a procedure allowing in vitro cell targeting by retroviruses. Biotinylated antibodies against the viral envelope protein on one side, and against specific cell membrane markers on the other side, were bridged by streptavidin and used to link the virus to the host. The method was successfully used to infect human cells with ecotropic murine retroviruses by means of major histocompatibility complex class I and class II antigens and appears easily adaptable to other cell, membrane markers. Moreover, the sequential protocol they design, although allowing infection of human cells, requires less stringent safety constraints than would handling of amphotropic virus stocks.

1989-12-01

290

Progress and Compliance in Alcohol Abuse Treatment*

Lung cancer staging according to the TNM system is based on morphological assessment of the primary cancer, lymph nodes and metastases. All aspects of this important oncological classification are measurable with MRI. Pulmonary nodules can be detected at the clinically relevant size of 4-5 mm in diameter. The extent of mediastinal, hilar and supraclavicular lymph node affection can be assessed at the same time. The predominant metastatic spread to the adrenal glands and spine can be detected in coronal orientation during dedicated MRI of the lungs. Search focused whole body MRI completes the staging. Various additional MR imaging techniques provide further functional and clinically relevant information during a single examination. In the oncological context the most important techniques are imaging of perfusion and tumor motion. Functional MRI of the lungs complements the pure staging and improves surgical approaches and radiotherapy planning. ...

2010-08-15

291

Pharmacological treatment of neuropathic pain in older persons

Improving patient compliance with physicians’ treatment or prescription recommendations is an important goal in medical practice. We examine the relationship between treatment progress...Full Text Available

2010-03-01

292

The superconducting critical temperature of radiation damaged A-15 compounds

Interest and research into the mechanisms and treatment of neuropathic pain have increased during recent years, but current treatment is still far from satisfactory (Dworkin...Full Text Available

2008-03-01

293

The European XFEL Free Electron Laser at DESY

Not Available

1978-05-01

294

ScienceCinema

...spontaneous radiation ...

295

THE ENVIRONMENTAL MANAGEMENT AND CO-ORDINATION ACT, 1999

Radiation processing technology for cosmetics: a report on a canadian study

Subject to the provisions of the Radiation Protection Act, the Authority, on the advice of ...(f) in collaboration with the Radiation Protection Board, conduct an ionising radiation monitoring programme and ...or document kept under the control of the Radiation Protection Board.

296

Radiation cryochemistry of cubic ice; Kriochemia radiacyjna lodu kubicznego

Short communications only.

1992-09-13

297

Monitoring station for medical effects of exposure during radiation accidents

No abstract prepared

1998-12-31

298

Measurement of UV radiation of LED lighting

Short communication.

1995-04-06

299

Ignition of a solid fuel by thermal radiation

Full Text Available

2011-03-01

300

Estimation of the radiation damages of the Uppsala spectator detector

Full Text Available

1998-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

Comparative characteristics of radiation accidents affecting population

No abstract prepared.

2002-03-01

302

???? ?? ???? ?? ?? ( Ignition of a Solid Fuel by Thermal Radiation )

Short communication.

1994-10-25

303

X-ray and UV-light irradiation effects on oxide superconducting thin films

Full Text Available

1998-03-01

304

Untersuchung von Bildqualitat und Genauigkeit der Dosisberechnung bei cone-beam-CT-Aufnahmen mit reduziertem Projektionsdatensatz (half scan, half fan) im Hinblick auf die Verwendbarkeit fur die adaptive Bestrahlungsplanung

Oxide superconducting thin films were irradiated with X-rays and ultra-violet (UV) light, and induced radiation effects on electrical and chemical properties were examined by transport measurement, X-ray diffraction analysis (XRD), diamagnetization measurement and X-ray photoemission spectroscopy (XPS). After irradiation for ErBa_2Cu_3O_x films with X-rays emitted from a Rh tube for 100 hours, superconductivity was remarkably damaged, destroying the zero-resistance state. The UV-light irradiation for Bi_2Sr_2CaCu_2O_x films was performed in He gas of about 500 Pa with a low pressure mercury lamp. The superconductivity was gradually degraded with the UV irradiation time up to 70 minutes. In both cases, adequate oxygen-annealing treatments restored superconductivity. The X-ray photoemission spectra showed that the mean Cu valence of the films was decreased approximately from +2 to +1 by the irradiation. From these results we can find that ...

305

British Library Electronic Table of Contents (United Kingdom)

Subject of this study is the question of whether cone beam CT (CBCT) images with reduced projection data are suitable for use in adaptive radiation therapy (ART) treatment planning. For this purpose image quality and dose calculation accuracy depending on imaging modality were analysed. In this context, two CBCT-methods will be indicated having reduced projection data sets: Scans acquired with 200^o rotation angle in order to accelerate the CBCT process (half scan), or scans with an asymmetric cone beam and detector offset, used to enlarge the field-of-view (half fan). Methods: For three different CBCT-modes (On-Board-Imaging, Varian Medical Systems), two of them based on reduced projection data, and a conventional multidetector CT system, the main image quality parameters were studied. Tr...

2011-01-01

306

The impact of accretion disk winds on the X-ray spectrum of AGN: Part 1 - XSCORT

Regulation of macrophage accessory cell activity by mycobacteria. I. Ia expression in normal and irradiated mice infected with Mycobacterium mycroti

(abridged) The accretion disk in AGN is expected to produce strong outflows, in particular a UV-line driven wind. Despite providing a good fit to the data, current spectral models of the X-ray spectrum of AGN observed through an accretion disk wind are ad-hoc in their treatment of the properties of the wind material. In order to address these limitations we adopt a numerical computation method that links a series of radiative transfer calculations, incorporating the effect of a global velocity field in a self-consistent manner (XSCORT). We present a series of example spectra from the XSCORT code that allow us to examine the shape of AGN X-ray spectra seen through a wind, for a range of velocity and density distributions, total column densities and initial ionization parameters. These detailed spectral models clearly show considerable complexity and structure that is strongly affected by all these factors. The presence of sharp features in the ...

2007-01-01

307

Radiation-enhanced diffusion in amorphous Pd-Cu-Si

CBA/Ca mice were infected by either the intravenous or intraperitoneal route with Mycobacterium microti and the subsequent changes in local macrophage populations examined. Following infection, the number of macrophages increased and they showed greater expression of both MHC Class II molecules. This response was not dependent on viability of the mycobacteria, in contrast to reports with other microorganisms such as Listeria. Studies in sublethally irradiated mice indicated that persistent antigen could give rise to a response after a period of host recovery which was radiation dose dependent. This procedure also highlighted differences in the regulation of different murine class II antigens in vivo, as seen by delayed re-expression of I-E antigens. Macrophage accessory cell function, as assessed by an in vitro T cell proliferation assay, correlated with Ia expression after fixation, but not after indomethacin treatment; this highlights the ...

308

Radiation-enhanced diffusion in amorphous Pd-Cu-Si

Diffusion during He/sup +/, Ne/sup +/, and Xe/sup +/ irradiations of trace amounts of Au in melt-spun amorphous Pd/sub 78/Cu/sub 6/Si/sub 16/ has been experimentally investigated. Diffusion constants were measured by following the changes in ion-implanted Au profiles with Rutherford-backscattering spectrometry. Heat treatments and simultaneous irradiations were performed as a function of temperature (533--588 K), ion flux, and ion mass. Total integrated fluences being very small, ion-beam-mixing effects are negligible. More than an order of magnitude enhancement in the diffusion was observed because of irradiations. This enhancement saturates at higher fluxes, the level being independent of ion mass, i.e., independent of collision-cascade parameters. Except at higher temperatures, where the enhancement decreases, the temperature dependence of the diffusion-saturation level is similar to that of the diffusion without irradiation. The data suggest that vacancylike ...

1988-11-01

309

Preliminary studies on the detection of irradiated prawns using 2-alkylcyclobutanones

Diffusion during He"+, Ne"+, and Xe"+ irradiations of trace amounts of Au in melt-spun amorphous Pd/sub 78/Cu_6Si/sub 16/ has been experimentally investigated. Diffusion constants were measured by following the changes in ion-implanted Au profiles with Rutherford-backscattering spectrometry. Heat treatments and simultaneous irradiations were performed as a function of temperature (533--588 K), ion flux, and ion mass. Total integrated fluences being very small, ion-beam-mixing effects are negligible. More than an order of magnitude enhancement in the diffusion was observed because of irradiations. This enhancement saturates at higher fluxes, the level being independent of ion mass, i.e., independent of collision-cascade parameters. Except at higher temperatures, where the enhancement decreases, the temperature dependence of the diffusion-saturation level is similar to that of the diffusion without irradiation. The data suggest that vacancylike defects play a ...

310

Irradiating the groin nodes without breaking a leg: A comparison of techniques for groin node irradiation

The use of ionising radiation for the preservation of food has been under investigation for many years but has yet to receive worldwide acceptance. Although irradiation can be carefully controlled, it is generally accepted that the development of a test or tests for the detection of irradiated food would enhance consumer confidence and might help to enforce labelling regulations. The 2-alkylcyclobutanones are reported to be the only cyclic compounds formed as the products of the radiolysis of saturated and unsaturated triglycerides. The synthesis of 2-dodecylcyclobutanone (DCB) and 2-tetradecylcyclobutanone (TCB), which are formed from palmitic and stearic acid respectively following irradiation, has been carried out and using irradiated chicken meat as the model for a high-lipid containing food, both cyclobutanones have been extracted with hexane and then identified using gas chromatography/mass spectrometry (GC/MS). DCB and TCB have been detected in chicken meat ...

1996-12-31

311

Investigation of natural radionuclides in selected NORM-samples

The purpose of this study was to determine the optimal technique for delivering postoperative radiotherapy for vulvar cancer and other tumors requiring treatment of the inguinal nodes. This project compared tumor coverage and normal tissue sparing for the 5 main radiotherapy techniques that are used to treat vulvar cancer. The intensity-modulated radiation therapy (IMRT) plan was undesirable because it resulted in an excessive dose to portions of the central pelvic structures. The photon thunderbird with skin match was unacceptable because it underdosed a portion of the groin region. The electron thunderbird was ideal for thin patients but was not applicable for most patients because of excessive dose to the skin and subcutaneous tissues. The photon through-and-through and the photon thunderbird with deep match were acceptable in most situations. In thin patients, where the depth of the inguinal vessels is less than 3 cm, the electron ...

312

Interaction of x-rays and food pyrolysis products in producing oncogenic transformation in vitro

A programme has been initiated by the Coordinating Office for Monitoring of enhanced natural radioactivity of the Federal Office for Radiation Protection to investigate different kinds of sample materials with enhanced naturally occurring radioactivity (NORM) such as scales from oilfield and naturally gasfield pipes, blast furnace sludge and sinter dust from the production of pig iron, as well as bauxit and red mud from the production of aluminium oxide. The aim of these investigations is to find proper preparation and measuring methods which allow, in particular, a sample treatment with optimised effort combined with a reliable determination of the specific activities of the dominating radionuclides. Of particular interest is the method of gamma-ray spectrometry, since this method has been used for most of our studies of sample materials. Due to different compositions of calibration and NORM-samples, e.g. different densities, and the analysis ...

2005-09-20

313

Enhancement of the decontamination factor for liquid radioactive waste and other radioactive materials

In recent years it has become evident from epidemiological and experimental data that a large number of environmental factors, including diet, play a role in modifying the incidence of cancer. Cell culture systems in which oncogenic transformation serves as an end point are powerful tools for evaluating these questions. Using such systems it has been shown recently that pyrolysis products from charred surfaces of broiled meat and fish can transform hamster embryo cells in vitro as well as produce tumors in the animal. Our studies in vitro have demonstrated the oncogenic potential of ionizing radiation in both hamster and human cells and have established in hamster cells the dose response relationship at doses ranging from 1 to 600 rad for x-rays and 0.1 to 150 rad for neutrons. The present work was aimed at evaluating whether there exists a cocarcinogenic interaction between a pyrolysis product and x-rays in their ability to transform hamster embryo cells in vitro. ...

1981-07-01

314

Dose planning and dose delivery in radiation therapy

Decommissioning of radiological and nuclear installations is for this century the new challenge. One of the performance criteria is the reduction of total quantities of radioactive materials (liquid or solid) arising from dismantling and decontamination of radiological and nuclear installations. In this work we present a new application of the water soluble polymers used as: - flocculation agents in treatment and conditioning process within the management of radioactive liquid materials; - strippable coatings on solid materials based on the water soluble polymers. The parameters of water soluble polymers made in our Institute by radiation processing have been analysed, namely the molecular average weight, composition, and efficiency of utilization of these polymeric materials as well as the content of ash, additives, decontamination factor, consumption per surfaces/liter, corrosion aspects, compatibility with various surfaces (of metal, ...

2003-10-20

315

Detecting exposure to environmental organic toxins in individual cells: towards development of a micro-fabricated device

A method has been developed for calibration of CT-numbers to volumetric electron density distributions using tissue substitutes of known elemental composition and experimentally determined electron density. This information have been used in a dose calculation method based on photon and electron interaction processes. The method utilizes a convolution integral between the photon fluence matrix and dose distribution kernels. Inhomogeneous media are accounted for using the theorems of Fano and O'Connor for scaling dose distribution kernels in proportion to electron density. For clinical application of a calculated dose plan, a method for prediction of accelerator output have been developed. The methods gives the number of monitor units that has to be given to obtain a certain absorbed dose to a point inside an irregular, inhomogeneous object. The method for verification of dose distributions outlined in this study makes it possible to exclude the treatment related ...

2008-08-01

316

Design experience of the JRR-2 BNCT facility in JAERI

A new method is being developed to quickly screen for the human exposure potential to polycyclic aromatic hydrocarbons (PAHs) and organochlorines (OCs). The development involves two key elements: identifying suitable signals that represent intracellular changes that are specific to PAH and OC exposure, and constructing a device to guide the biological cell growth so that signals from individual cells are consistent and reproducible. We are completing the identification of suitable signals by using synchrotron radiation-based (SR) Fourier-transform infrared (FTIR) spectromicroscopy in the mid-infrared region (4000-400 cm-1). Distinct changes have been observed in the IR spectra after treatment of human cells in culture medium with PAHs and OCs. The potential use of this method for detecting exposure to PAHs and OCs has been tested and compared to a reverse transcription polymerase chain reaction (RT-PCR) assay that quantifies increased ...

1999-01-10

317

Corrections to quark asymmetries at LEP

The thermal neutron column of the JRR-2 reactor was remodelled in order to install a medical irradiation facility. The design experience and the cource of this remodelling are presented. At first, the thermal neutron flux was lower than expected, and the expected radiation condition was achieved by the following improvements: (1) removal of graphite from the thermal neutron column to increase the neutron flux, (2) twice increase of bismuth shielding and the shift of its position to improve the shielding effect against gamma ray, (3) application of B{sub 4}C rubber on the both surfaces of the shielding door to suppress the secondary gamma ray generation from the structural materials, (4) LiF tiles are applied on the inner face of the neutron beam exit hole to suppress the secondary gamma ray from the beam exit, and (5) installment a cone-shape polyethylene collimator to relieve the decay of thermal neutron. After the improvements, medical irradiation ...

1994-06-01

318

Computed Tomography in staging and follow-up of thoracic Hodgkin's diseases

The most precise measurement of the weak mixing angle sin{sup 2} {theta}{sub eff}{sup l} at LEP is from the forward-backward asymmetry e{sup +}e{sup -} {yields} b{bar b} at the Z-pole. In this note the QED and electroweak radiative corrections to obtain the pole asymmetry from the measured asymmetry for b- and c-quarks have been calculated using ZFITTER, which has been amended to allow a consistent treatment of partial two-loop corrections for the b-quark final asymmetries. A total correction of {delta}A{sub FB}{sup b} = 0.0019 {+-} 0.0002 and {delta}A{sub FB}{sup c} = 0.0064 {+-} 0.0001 has been found, where the remaining theoretical uncertainty is much too small to explain the apparent discrepancy between sin{sup 2} {theta}{sub eff}{sup l} obtained from A{sub FB}{sup b} and from the left-right asymmetry at SLD.

2004-11-01

319

Activation of Polymethyl-Methacrylate by Proton Beam

As yet, the role of Computed Tomography (CT) as a routine imaging technique in the staging and follow-up of thoracic Hodgkin's disease has not been assessed. The authors reported the results obtained in 120 patients affected with thoracic Hodgkin's disease, staged and followed by means af chest X-rays and CT. CT better identified intrathoracic involvement of mediastinal nodes, of lung parenchyma, of pleura, and of pericarcial and chest walls in 54/120 patients (45%), with staging modifications in 18 (15%) of them only. Treatment was changed only in 12 patients (19%) where radiation therapy had been planned. The clinical value of the additional information yielded by CT was especially evident in the follow-up: CT allowed the correct evaluation of persistent/ recurrent disease in 51/117 patients (43.5%), a figure high enough to suggest the use of CT in the routive follow-up of patients affected with thoracic Hodgkin's disease.

1990-01-01

320

Studies on lipids in fractions of spherosomes and mitochondria of #gamma#-irradiated seeds of peanuts and walnuts

Activation has been used for many kinds of useful applications, such as use of the radioisotopes for diagnosis and treatment of cancer, and wear (or corrosion) investigation for using thin layer activation (TLA) technique, etc. But activation also has severe problems for the post-processing of the samples; such as time-loss, inconvenience of sample handling, personal radiation safety, etc. For in-vitro experiments, we observed death of tumor cells by proton irradiation. The use of large activated container material can cause erroneous results in this case. To solve these problems, we studied why the samples were activated and how the level of the activation could be reduced. In proton beam irradiation experiments, the target materials could be defined as the container and sample itself. We could easily reduce activation of container material comparing to activation of sample itself. Therefore, we tried to find less activated container material ...

2010-10-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

Radiation Therapy and Cisplatin With or Without Amifostine in Treating Patients With Stage IIIB or Stage IVA Cancer of the Cervix

... chemical radiation effects decomposition extraction columns gamma radiation

1972-01-01

322

Cervical Cancer; Radiation Toxicity

2011-09-09

323

NAME=\\

Measurement of fast fluctuations of radiation intensity in pulsed charged particle accelerators

... Radiation Protection Products and Equipment Find and compare a variety of radiation protection products and equipment on the world's largest environmental industry portal. View product ...

324

Wetland Performance for Wastewater Treatment in Growing and Winter Seasons

... beam monitoring betatrons delay circuits errors fluctuations gamma radiation

325

Treatment of Rice-Washing Wastewater by ph Adjustment

Full Text Available

1999-08-01

326

Treatment of Artificial Sewage Using a Zeolite Column

Full Text Available

1994-08-01

327

Surgical treatment of subretinal neovascular membrane.

Full Text Available

2002-09-01

328

Paying for treatments? Influences on negotiating clinical need and decision-making for dental implant treatment

Full Text Available

1999-06-01

329

Metformin Versus Insulin in the Treatment of Gestational Diabetes Mellitus

BackgroundThe aim of this study is to examine how clinicians and patients negotiate clinical need and treatment decisions within a context of finite resources. Dental implant treatment...Full Text Available

330

Materials science and technology a comprehensive treatment

Gestational Diabetes Mellitus

2010-03-15

331

Effectiveness of Selective Peripheral Denervation for the Treatment of Spasmodic Torticollis

Materials science and technology

1991-01-01

332

Demineralization of Crab Shells by Chemical and Biological Treatments

Full Text Available

2005-11-01

333

Three-Dimensional Rotational Angiography of the Inferior Vena Cava as an Adjunct to Inferior Vena Cava Filter Retrieval

Full Text Available

2005-02-01

334

Standards and guidances for limiting ionizing radiation exposure

The objective of this study was to explore the role of three-dimensional (3-D) rotational angiography (RA) of the inferior vena cava (IVC; 3-D CV) before filter retrieval and its impact on treatment planning compared with standard anteroposterior cavography (sCV). Thirty patients underwent sCV and 3-D CV before IVC filter retrieval. Parameters assessed were: projection of filter arms or legs beyond the caval lumen, thrombus burden within the filter and IVC, and orientation of the filter within IVC. Skin and effective radiation doses were calculated. Statistical analysis was performed using paired Student t test and nonparametric McNemar's test. Standard anteroposterior cavography detected 49 filter arms or legs projecting beyond the caval lumen in 25 patients. Three-dimensional CV demonstrated 89 filter arms or legs projecting beyond the caval lumen in 28 patients. Twenty-two patients had additional filter arms or legs projecting beyond the ...

2009-01-01

335

Radiation protection in the operating room

This chapter is concerned with standards and guidances for limiting radiation exposures. It is divided into three sections, each of which has several parts. Section 1: Ionizing Radiation -- Standards and Guidances Applicable to the Public: Part A, Radiation Protection Standards; Part B, Environmental Radiation Standards; Part C, Exempt Levels of Radioactivity; Part D, Protective Action Guides for Accidents. Section 2: Ionizing Radiation -- Standards Applicable to the Workplace. Section 3: Medical and Other Standards.

1992-12-31

336

Spinal cord stimulation in treatment of chronic benign pain: challenges in treatment planning and present status, a 22-year experience.

On the basis of legally provided area dose measurements and time records of fluoroscopic examinations during the operation, radiation doses to medical personnel and patients are evaluated. Adequate radiation protection measures and a careful behaviour in the operating room keep the radiation exposure to the personnel below the maximum permissible exposure. Taking into account the continuous personnel radiation monitoring and medical supervision, radiation hazards in the operating room can be considered low.

337

Survey of Radiation Protection Education and Training in Finland in 2003

PMID:16528188

2006-03-01

338

Role of radiation therapy in the management of nonmetastatic Ewing's sarcoma of bone. Report of the intergroup Ewing's sarcoma study

The current state and need for radiation protection training in Finland have been surveyed by the Radiation and Nuclear Safety Authority STUK. The survey sought to determine whether the current requirements for radiation protection training had been met, and to promote radiation protection training. Details of the scope and quality of present radiation protection training were requested from all educational institutes and organizations providing radiation protection training. The survey covered both basic and further training, special training of radiation safety officers, and supplementary training. The questionnaire was sent to 77 educational organization units, 66 per cent of which responded. Radiation workers and radiation safety officers were asked about radiation protection ...

2004-07-01

339

Population doses from beam-therapy in Japan, 1978, 3

The role of radiation therapy in local tumor control and decreased incidence of pulmonary metastasis is reported in 271 patients who were entered into the Intergroup Ewing's Sarcoma Study with more than one year follow-up and on whom all radiotherapy records were reviewed. The majority of the patients were irradiated to the primary tumor with doses of 4500 to 6500 rad in five to six weeks in combination with systemic administration of three drugs (vincristine, actinomycin-D and cyclophosphamide) or four drugs (vincristine, actinomycin-D, cyclophosphamide and adriamycin). One of the groups of patients was treated with three drugs and bilateral pulmonary irradiation (1500 rad, uncorrected dose, in two weeks). Preliminary analysis shows an overall local primary tumor control of 89%. Patients with lesions in the pelvis had a local failure rate of 17% (9 of 52) and in the humerus 23% (7 of 31). Factors affecting local recurrences are analyzed in detail. Distant ...

340

Impact of more intensive written information in patients having radical radiation therapy: Results of a prospective randomized phase III trial

As a series of estimations of population doses and of risk estimates from medical exposures in Japan, the malignancy significant dose (MSD) and the fatal malignant risk from beam therapy were estimated based on a nationwide survey of radiotherapeutic treatments, using a malignancy significant factor and a weighting factor determined from the data on the cancer mortality among the atomic bomb survivors in Nagasaki. The effective dose was defined as a sum of the product of the weighting factor and the organ or tissue doses with respect to the malignant diseases. The organ or tissue doses were determined with ionization chambers placed at the positions of their center in a MixDp-phantom simulated lung tissues by a block of cork, using a telecobalt unit, a conventional X-ray unit and a medical linear accelerator. The organ or tissue doses were categorized into three dose components; namely 1) dose from useful beams; 2) scattered radiation dose from ...

1981-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

Gamma radiation effects at color, antioxidant capacity and fatty acid profile in peanut (Arachis hypogaea L.)

Background and purpose: A diagnosis of malignancy and its treatment is a very stressful time for patients and their families. This study was conducted to determine the impact of more intensive written information on patients' anxiety levels. The secondary aim was to determine the impact of this information on patients' satisfaction levels. Materials and methods: This prospective randomized trial consisted of patients with a pathological diagnosis of cancer having radical radiotherapy (RT). Patients were randomized to receive the more intensive information (including written information and a telephone call from the research nurse) or not to receive the more intensive information at the time of their initial consultation with the radiation oncologist. Study questionnaires measuring anxiety (STAI form) were completed prior to their first consultation (baseline) at the time of simulation (pre-RT) and at the completion of radiotherapy. A second ...

2010-08-01

342

Evaluation of a process for the decontamination of radioactive hotspots due to activated stellite particles

Irradiation is efficient at extinction fungi contamination in peanuts. Peanuts have high biologic value protein, minerals, vitamin E, complex B, and high concentration of lipids. The objective of this research is to evaluate the gamma irradiation effect on color, total phenolic, antioxidant activity, and fatty acid profile in peanuts (Arachis hypogaea L.). Cultivars IAC-Tatu ST and IAC-Runner 886 were submitted to gamma radiation with doses of 5.0; 7.5; 10.0, and 15.0 kGy and storage at room temperature. There was no significant difference in the color of IAC-Tatu ST. However, significant difference was found in the luminosity and Chroma in IAC-Runner 886. Total fenolics differed from the control with 33.27 mg.g-1 and treatment dose of 10.0 kGy with 58.60 mg.g-1 in IAC-Tatu ST. This parameter not had significant difference in IAC-Runner 886 and the control with 51.59 mg.g-1. The antioxidant activity did not present significant difference with a ...

2011-01-01

343

Development of functional foods for radiation workers - Search for the active components and studies on the mechanism of the hematopoiesis improvement foods

Some of the Indian pressurized heavy water reactors (PHWRs) which use Stellite balls in the ball and screw mechanism of the adjustor rod drive mechanism in the moderator circuit have encountered high radiation fields in the moderator system due to "6"0Co. Release of particulate Stellite is responsible for the hotspots in addition to the general uniform contamination of internal surfaces with "6"0Co. Extensive laboratory studies have shown that it is possible to dissolve these Stellite particles by adopting a three-step redox process with permanganic acid as the oxidizing agent. These investigations with inactive Stellite in powder form helped to optimize the process conditions. Permanganic acid was found to have the highest dissolution efficiency as compared to alkaline and nitric acid permanganate. The susceptibility of Stellite to corrode or dissolve was found to depend on the concentration of the permanganate, pH and temperature of the process and microstructure ...

2011-06-01

344

A survey of monitoring and assay systems for release of metals from radiation controlled areas at LANL.

In this experiments, we established long-termed culture methods of bone marrow stromal cells for proliferation and differentiation of stem cells. And we selected some extracts which support maximal proliferation of stromal cells with this method. We conformed the synergic effects of herbal mixture extracts for stromal cell growth. The proliferation of stromal cells was increased rather by the addition of mixture extracts than by addition of single strain extract. In the previous and cooperative experiments, we selected complex extracts (Him-I, Him-II) which increased the number of nonadherent mononuclear cells. Different cytokine expression patterns were observed stromal cells cultured in the presence or absence of mixture extracts which support differentiation of nonadherent cells. Some fractions of Him-I and Him-II increased the proliferation of bone marrow cells irradiated {gamma}-ray(4Gray). Stimulation of macrophage cell line with herval extracts with the ...

2000-04-01

345

Update of the management strategy for Oak Ridge National Laboratory Liquid Low-Level Waste

At Los Alamos National Laboratory (LANL), a recent effort in waste minimization has focused on scrap metal from radiological controlled areas (RCAs). In particular, scrap metal from RCAs needs to be dispositioned in a reasonable and cost effective manner. Recycling of DOE scrap metals from RCAs is currently under a self-imposed moratorium. Since recycling is not available and reuse is difficult, often metal waste from RCAs, which could otherwise be recycled, is disposed of as low-level waste. Estimates at LANL put the cost of low-level waste disposal at $550 to $4000 per cubic meter, depending on the type of waste and the disposal site. If the waste is mixed, the cost for treatment and disposal can be as high as $50,000 per cubic meter. Disposal of scrap metal as low-level waste uses up valuable space in the low-level waste disposal areas and requires transportation to the disposal site under Department of Transportation (DOT) regulations for low-level waste. In ...

2002-01-01

346

Status of the ORNL liquid low-level waste management upgrades

The strategy for management of the Oak Ridge National Laboratory`s (ORNL) radioactively contaminated liquid waste was reviewed in 1991. The latest information available through the end of 1990 on waste characterization, regulations, US Department of Energy (DOE) budget guidance, and research and development programs was evaluated to determine how the strategy should be revised. Few changes are needed to update the strategy to reflect new waste characterization, research, and regulatory information. However, recent budget guidance from DOE indicates that minimum funding will not be sufficient to accomplish original objectives to upgrade the liquid low-level waste (LLLW) system to comply with the Federal Facilities Agreement, provide long-term LLLW treatment capability, and minimize environmental, safety, and health risks. Options are presented that might allow the ORNL LLLW system to continue operations temporarily, but they would significantly reduce its ...

1995-04-01

347

Relationship of DNA repair processes to mutagenesis and carcinogenesis in mammalian cells. Progress report, November 1, 1979-October 31, 1980

The strategy for management of the Oak Ridge National Laboratory`s (ORNL`s) radioactively contaminated liquid waste was reviewed. The latest information on waste characterization, regulations, US Department of Energy (DOE) budget guidance, and research and development programs was evaluated to determine how the strategy should be revised. Few changes are needed to update the strategy to reflect new waste characterization, research, and regulatory information. However, recent budget guidance from DOE indicates that minimum funding will not be sufficient to accomplish original objectives to upgrade the liquid low-level waste (LLLW) system to be in compliance with the Federal Facilities Agreement compliance, provide long-term LLLW treatment capability, and minimize Environmental Safety & Health risks. Options are presented that might allow the ORNL LLLW system to continue operations temporarily but significantly reduce its capabilities to handle emergency ...

1995-08-01

348

Regulatory quality assurance requirements for the operation of nuclear R and D facilities in Korea

The objective of this research is to determine the role of DNA repair in mutagenesis and carcinogenesis in mammalian cells. Use of the host-cell reactivation viral suicide enrichment procedure was initiated in the isolation of repair-deficient mutants. Lightly mutagenized BHK cells were infected with irradiated Herpes simplex virus (HSV); several radiation-sensitive strains were isolated among the survivors of the infection. The characterization of these strains is progressing and the enrichments are continuing. That alterations in the frequency of mutation of C3H/10T 1/2 cells, occurring as a result of holding the cells in a confluent state following treatment with ethylmethane sulfonate, parallel the alterations in the frequency of neoplastic transformation was found. The repair capabilities of BHK cells were found to be intermediate in comparison to repair-proficient and -deficient human cells with regard to the reactivation of HSV treated ...

349

Phase I Study of Conformal Radiotherapy and Concurrent Full-Dose Gemcitabine with Erlotinib for Unresected Pancreatic Cancer.

Full text: Korea Atomic Energy Research Institute (KAERI) has many R and D facilities in operation. including HANARO research reactor, radioactive waste treatment facility (RWTF), post-irradiation examination facility (PIEF) and irradiated material test facility (IMEF). Recently. nation-wide interest is focused on the safety and security of major industrial facilities. Safe operation of nuclear facilities is imperative because of the consequence of public disaster by radiological release/contamination, in case of an accident. Recently, Ministry of Science and Technology (MOST) of the Korean government announced amendments of Atomic Energy laws to enforce requirements of the physical protection and radiological emergency. All provisions on nuclear safety regulation and radiation protection are entrusted to the Atomic Energy Act(AEA). The Act is enacted as the main law concerning the safety regulation of nuclear installations, and is supplemented ...

2006-10-15

350

Phase 2 report on the evaluation of polyacrylonitrile (PAN) as a binding polymer for absorbers used to treat liquid radioactive wastes

PURPOSE: To determine the recommended dose of radiotherapy when combined with full-dose gemcitabine and erlotinib for unresected pancreas cancer. METHODS AND MATERIALS: Patients with unresected pancreatic cancer (Zubrod performance status 0-2) were eligible for the present study. Gemcitabine was given weekly for 7 weeks (1,000 mg/m(2)) with erlotinib daily for 8 weeks (100 mg). A final toxicity assessment was performed in Week 9. Radiotherapy (starting at 30 Gy in 2-Gy fractions, 5 d/wk) was given to the gross tumor plus a 1-cm margin starting with the first dose of gemcitabine. A standard 3 plus 3 dose escalation (an additional 4 Gy within 2 days for each dose level) was used, except for the starting dose level, which was scheduled to contain 6 patients. In general, Grade 3 or greater gastrointestinal toxicity was considered a dose-limiting toxicity, except for Grade 3 anorexia or Grade 3 fatigue alone. RESULTS: A total of 20 patients were treated (10 men and 10 women). Nausea, ...

2011-05-01

351

Genotoxicity of 2-alkylcyclobutanones, markers for an irradiation treatment in fat-containing food--Part I: cyto- and genotoxic potential of 2-tetradecylcyclobutanone

The performance of PAN-based composite absorbers was evaluated in dynamic experiments at flow rates ranging from 25--100 bed volumes (BV) per hour. Composite absorbers with active components of ammonium molybdophosphate (AMP) PAN and K-Co ferrocyanide (KCoFC) PAN were used for separating Cs from a 1 M HNO{sub 3} + 1 M NaNO{sub 3} + 2 {times} 10{sup {minus}5} M CsCl acidic simulant solution. KCoFC-PAN and two other FC-based composite absorbers were tested for separating Cs from alkaline simulant solutions containing 0.01 M to 1 M NaOH and 1 M NaNO{sub 3} + x {times} 10{sup {minus}4} M CsCl. The efficiency of the Cs sorption on the AMP-PAN absorber from acidic simulant solutions was negatively influenced by the dissolution of the AMP active component. At flow rates of 50 BV/hr, the decontamination factor of about 10{sup 3} could be maintained for treatment of 380 BV of the feed. With the KCoFC-PAN absorber, the decontamination factor of about 10{sup 3} could be ...

1996-05-01

352

Disposal of old heads for Daya Bay NPP

Previous experiments had indicated a slight genotoxic potential both in rat and in human colon cells of a sample of 2-dodecylcyclobutanone, a compound formed by irradiation of food containing palmitic acid in its triglycerides. Up to date, there is no evidence that 2-alkylcyclobutanones occur in non-irradiated foodstuffs, consequently it is prudent to test several members of the class of 2-alkylcyclobutanones which are produced by treatment of fat-containing food with ionising radiation. In this work, 2-tetradecylcyclobutanone (derived from stearic acid) has been tested for its cytotoxic and genotoxic potential. Human colon tumor cell lines, i.e. HT 29 and HT 29 clone 19A, were employed as models for in vitro experiments for cytotoxicity and genotoxicity tests. Cytotoxicity was measured by tetrazolium salt reduction assays (MTT and WST-1) and genotoxicity by determining DNA damage using the Comet Assay. Neither cytotoxic nor genotoxic effects ...

2002-03-01

353

Decontamination of the reactor coolant pump in Maanshan nuclear power plant

The paper introduces the disposal procedures of the old reactor pressure vessel head. Reactor pressure vessel (RPV) heads were replaced successfully in Daya Bay Nuclear Power Plant. The on-site treatment and disposal of replaced heads was thereafter implemented. This is the first time in China for large size radioactive article disposal. To guarantee the safety of old head treatment, issues of radiation protection have to be taken into account. Dose rate distribution of the old head surface and radioactivity were initially calculated according to the operation history and the neutron flux rate of the reactor. Shielding calculation and package design was thereafter worked out based on the data obtained from the old head, e.g. neutron flux, sorts of nuclides, radioactivity and dose rates. Shielding package was afterwards manufactured in special factories and transported to Daya Bay NPP site by truck and ship. The shielding ...

354

Cutaneous and subcutaneous Ewing's sarcoma: an indolent disease

To reduce the radiation dose that accumulated on the reactor coolant pump, decontamination work was carried out at the Maanshan Nuclear Power Plant. A four-step alkaline permanganate (AP)-CanDecon process was applied to remove the activity on the turning vane diffuser and pump impeller. The first step consisted of 8 h of AP treatment and 7 h of decontamination. It was followed by 2.5 h of AP treatment and 5 h of decontamination. An average decontamination factor of 2.9 was obtained. To understand the corrosion of the decontaminating reagents on the materials, coupons were installed in the decontamination tank. These were as-received and sensitized 304SS, alloy 600, casting stainless steel (CF-8), stellite-6, and carbon steels (A508 and A533). The exposure rates (mR h"-"1) of the carbon steels were approximately five times higher in magnitude than those of the other materials. The decontamination levels (dpm per 100 cm"2) of ...

355

MRI evaluation and image processing in gel dosimetry. A study of selected MRI properties and image processing in 3D gel dosimetry

Purpose: The occurrence of extraosseous Ewing's sarcoma (ES) in deep soft tissues has been well described, but cases in which this tumor occurs in a primary cutaneous or subcutaneous site have rarely been reported. The superficial variant may be less aggressive than are the more common bony and deep soft tissue counterparts with an apparently favorable outcome. A retrospective review of patients with cutaneous or subcutaneous ES was conducted to analyze outcome and patterns of failure. Methods and Materials: Between July 1985 and March 1997, 14 patients with cutaneous or subcutaneous ES were treated at St. Jude Children's Research Hospital. The median age at presentation was 16 years (range 7-21 years). Anatomic locations included trunk and pelvis (7), upper or lower extremity (4), and head and neck (3). The median size of the lesion was 3 cm (range, 1-12 cm). Thirteen had definitive surgical resections, and one had biopsy of the mass at the time of referral. They were enrolled on ...

2000-01-15

356

Stimulated radiation of high - current relativistic electron beams

Gel dosimetry is a new dosimetry method applied in radiation therapy. Gel dosimeters consist of a radiation sensitive gel, which can integrate absorbed doses from several radiation sources or beams. The dose to the gel can be evaluated by magnetic resonance imaging (MRI), a procedure that is the focus of the present thesis. A robust tool for the evaluation of the nonuniformity in MRI has been developed, the Deviation Image method. Unlike previously presented methods, the Deviation Image method includes all nonuniformity variations across a phantom surface and is insensitive to stochastic noise. Methods for the estimation of stochastic noise were analyzed in terms of sensitivity to nonuniformities. A method that averages the stochastic noise level over five regions over the phantom surface, and a method that assesses the stochastic noise level from the background, were found to be the methods of choice. Pronounced MR image ...

2001-03-01

357

Radiation protection. A guide for scientists and physicians

The most propagated mechanisms of stimulated radiation of electron beam such as Cherenkov one-particle and collective effects, ondulator and magnetic bremsshrahlung radiations, Doppler anomalous effect, Thompson and Raman scattering and radiation are discussed. Relation of spontaneous radiation mechanisms of individual electron and stimulated radiation effects in electron beams has been elucidated, grounds of linear electrodynamics of radiative beam instabilities are stated, and main mechanisms of their nonlinear stabilization are elucidated as well. Various simulated processes in electron beams are considered from the unique point of view using a simple mathematical apparatus and such physical laws as conservation and Newton laws.

1987-01-01

358

Combining satellite data and models to estimate cloud radiative effect at the surface and in the atmosphere

This manual was written for individuals who wish to become qualified in radiation protection as an adjunct to working with sources of ionizing radiation or using radionuclides in the field of medicine. It provides the radiation user with information needed to protect himself and others and to understand and comply with governmental and institutional regulations regarding the use of radionuclides and radiation machines. It is designed for a wide spectrum of users, including physicians, research scientists, engineers, and technicians. It should be useful also to radiation safety officers, members of radiation safety committees, and others who are responsible for the proper use of radiation sources, although they may not be working with the sources directly. The presentation in this manual is designed to obviate the need for reviews of atomic ...

359

British Library Electronic Table of Contents (United Kingdom)

Abstract Satellite measurements and numerical forecast model reanalysis data are used to compute an updated estimate of the cloud radiative effect on the global multi-annual mean radiative energy budget of the atmosphere and surface. The cloud radiative cooling effect through reflection of short wave radiation dominates over the long wave heating effect, resulting in a net cooling of the climate system of - 21 Wm-2. The short wave radiative effect of cloud is primarily manifest as a reduction in the solar radiation absorbed at the surface of - 53 Wm-2. Clouds impact long wave radiation by heating the moist tropical atmosphere (up to around 40 Wm-2 for global annual means) while enhancing the radiative cooling of the atmosphere over other regions, in particular higher latitudes and sub-trop...

2011-01-01

360

Biological effects of electromagnetic radiation in the microwave range

[The indicators of biological age and accelerated aging in liquidators of the consequences of radiation emergency].

The book examines current experimental and clinical knowledge concerning the biological and biophysical effects of electromagnetic radiation, particularly that in the microwave range. The biophysical bases of the interaction of electromagnetic radiation with matter are reviewed with emphasis on biological systems, and the effects of radiation on critical biological systems, including the nervous, reproductive, visual and blood-forming systems are compared. Data concerning the lethal effects of nonionizing radiation is presented and characteristics of the effects of electromagnetic radiation on the whole mammalian organisms are examined. Various reactions of the neuroendocrine system to electromagnetic radiation are described, with particular attention given to the adrenal system, and the combined effects of ionizing and microwave radiation ...

1980-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

The THz Radiation from Undulator

The biological age (BA) of the majority of the liquidators of the consequences of the radiation accidents in the Navy and of the liquidators of the Chernobyl' APS accident exceeds the medium standard and the DBA (due BA). The index of the BA can be a characteristic of the influence of the social-hygienic factors on the health condition of the Special Risk Subunit--the liquidators of the consequences of the radiation accidents. It was established, that the radiation influence concerns to the factors dramatically increasing the BA and the rate of senescence of the liquidators of the consequences of the radiation accidents. PMID:21809627

2011-01-01

362

Study of emission of Cerenkov radiation by tachyons

The experimental device for generation of undulator radiation in terahertz wavelength region by use of undulator with ferromagnets is created. The device is based on a beam of a microtron with the energy 7.5 MeV. The radiation wavelength is 200 mu. Registered spontaneous radiation has a power 10{sup -6} W at a current of a beam 2 mA in a pulse. With the optical resonator, in a mode, the amplification of 6% is received, that in sometimes is more than the expected value. This effect is explained as a result of partial coherence of radiation.

2010-02-03

363

Radiation facility with electron accelerator of the Institute for Nuclear Research of Ukraine, Kiev

The emission of Cerenkov radiation by tachyons has been examined by using the reduced expansions of superluminal electromagnetic fields in terms of standard helicity representation of Poincare group. It has been shown that the tachyons emit Cerenkov radiation through their coupling only with subluminal electromagnetic fields and that a charged tachyon can emit Cerenkov radiation only in the media in which it travels with a velocity lower than that of light while in the usual medium in which its velocity is more than that of light, it will never emit Cerenkov radiation.

1983-01-01

364

Radiation exposure of the population of the GDR by X-ray diagnostics

Characteristics of the Ukrainian NSA NRI radiation facility for scientific researches and developments of industrial radiation technology are performed. Parts of the facility, design peculiarities of technical tools are described. Biological protection of the facility and radiation protection system, transport line, systems of technical provision and radiation measurements are discussed

2003-02-01

365

Potential Hazards from Neutrino Radiation at Muon Colliders

The radiation burden of the people of the GDR in relation to biomedical radiography altogether as well as organ doses, gonad doses and genetically significant doses in detail are outlined. The concepts of radiation protection and standards of radiographic examination are demonstrated. Possibilities of influencing radiation exposure by scientifically based indication of X-ray examination, application of new and improvement of usual examination techniques are discussed with regard to quality assurance and control. Proposals concerning the reduction of radiation exposure of the GDR population are presented.

1986-01-01

366

Model of quantum noise of shadow radiation images

High energy muon colliders, such as the TeV-scale conceptual designs now being considered, are found to produce enough high energy neutrinos to constitute a potentially serious off-site radiation hazard in the neighbourhood of the accelerator site. A general characterization of this radiation hazard is given, followed by an order-of-magnitude calculation for the off-site annual radiation dose and a discussion of accelerator design and site selection strategies to minimize the radiation hazard.

1999-01-01

367

Coherent oscillator radiation

Correlation characteristics of quantum noise on the shadow radiation image (RI) of the object under nondestructive testing are studied. Mathematical model of RI occasional distortions is derived. The model takes into account the parameters of object under testing and of radiation beam by radiation quanta flux density. The results obtained can be used as a component in the process of investigation of various radiation testing systems

368

Study of particles trapped by a magnetic field

Coherent oscillator radiation is considered. A comparison is made with classical particle radiation with gauss distribution. Decay probability for coherent state in spontaneous radiation is estimated. The method suggested for describing harmonic oscillator allows to separate the effect of classical field radiation from quantum description of particle state within the framework of a self-consistent quantum mechanical problem.

1982-04-01

369

Study of Maytenus aquifolium martius chemical compounds stability face to ionizing radiations (x radiation and gamma radiation); Estudo da estabilidade dos compostos quimicos de Maytenus aquifolium martius frente a radiacao ionizante (X e Y)

A new type of radiation which occurs when particles are accelerated in the field of a longitudinal wave and in a transverse magnetic field is studied. The characteristics of such spontaneous radiation are obtained, and the influence of collective effects on the radiation is analyzed. The application of the findings to the theory of free electron lasers is discussed. 8 references.

1986-01-01

370

Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries

No abstract prepared

1996-09-01

371

Radiation exposure due to X-rays of the hip joint in babies

Objectives To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental,...Full Text Available

2005-07-09

372

Lagranzheva dinamika kollektivnykh vzaimodejstvij v potokakh diskretnykh izluchatelej. (Lagrange dynamics of collective interactions in flows of discrete radiators).

Exact anatomic knowledge about the location of the gonads and the application of corresponding measures of radiation protection are the preconditions for an efficient reduction of the danger of a possible genetic damage as a result of radiation exposition during X-ray examination of the hip joint of newborns. (VJ).

373

Granite Countertops and Radiation | Radiation Protection | US EPA

Analytical method of theoretical simulation of collective hydrodynamic instabilities of intensive flows of discrete radiators, interacting with each other only through the coherent fields of their spontaneous radiation in corresponding media was suggested...

1989-01-01

374

Are natural radioactive materials dangerous

... Top of page Testing Radiation coming from granite countertops results from natural radioactive material in the granite. Identifying the presence and concentration of radioactive elements in granite requires expensive and sophisticated portable instruments or laboratory equipment. These instruments and equipment require proper calibration, and interpretation of ...

375

A radiator of electromagnetic waves with a combined shape of generatrices

The different radiation loads caused by natural and artificial radionuclides are compared in this paper. This examples will serve to illustrate that the problem of population exposure to radiation can only be solved in consideration of all components and to show which effects of the radiation from natural sources are of special importance in this connexion. (orig./AK).

1974-09-23

376

British Library Electronic Table of Contents (United Kingdom)

The problem of optimizing a horn radiator of electromagnetic waves for the reflection coefficient and the coefficient of transformation of the fundamental mode into higher order modes is solved. Optimization is performed by means of selecting a combined shape of the radiator generatrices.

2008-01-01

377

Using ICCD as a fast optical switch to measure harmonic super-radiation from an optical klystron in a storage ring

The medical exposures to ionizing radiations, it is a world priority in radiation protection

An optical klystron is built in the 800 MeV electron storage ring at University of Science and Technology of China for harmonic super-radiation generation. In single bunch operation mode the repetition rate of the spontaneous radiation pulses is about 4.533 MHz, and the repetition rate of the seed laser pulses is about 3 Hz, while the radiation pulse duration is 300 ps. For measuring harmonic radiation a high on/off ratio ICCD is used as an optical switch to reject spontaneous radiation pulses of high repetition rate

2001-07-01

378

Treatment planning for children with attention-deficit/hyperactivity disorder: treatment utilization and family preferences

The document published under A/63:46 and titled report of the scientific committee of United Nations for the study of ionizing radiations effects, gives the situation of the fifty sixth session of the committee that stood at Vienna from the 10. to 18. july 2008. In the chapter 3 of this report the writers summarize the strategic planning and the working program of the scientific committee for the period 2009-2013. They note that the committee worry about the inadequate means, particularly in personnel. The priorities for the given period will be the medical exposure of patients, the radiation levels and the effects of energy production, the exposure to natural radiation sources and the improvement of the understanding of the effects of the low doses radiation exposure. (N.C.)

379

Qualitative and Quantitative Effects of Treatment for Dental Fear and Avoidance

BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a common condition that often results in child and family functional impairments. Although there are evidence-based treatment...Full Text Available

380

Policy Progress for Physician Treatment of Opiate Addiction

In a Swedish community-based program for the treatment of dental phobic patients, a clinical trial was performed among 99 severely phobic individuals with long-standing avoidance of dental treatment....Full Text Available

1986-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

381

Interest in Behavioral and Psychological Treatments Delivered Face-to-Face, by Telephone and by Internet

Medical treatment of heroin addiction with methadone and other pharmacotherapies has important benefits for individuals and society. However, regulatory policies have separated this treatment from the...Full Text Available

2002-05-01

382

Improvement of structure and mechanical properties of cast titanium alloys using rapid heat treatment

BackgroundLittle is known about the acceptability of internet and telephone treatments, or what factors might influence patient interest in receiving treatments via...Full Text Available

2010-08-01

383

Differing prognosis of cervical cancer patients with high risk of treatment failure after radical hysterectomy warrants trial treatment modification

The possibility of rapid heat treatment (RHT) application to titanium castings has been studied. It was shown that such treatment provides a significant improvement of intragrain structure and mechanical properties of cast ({alpha}+{beta})-titanium alloys. ((orig.))

1995-01-01

384

x - NASA Technical Reports Server

ObjectiveThe aim of this study was to ascertain whether all cervical cancer patients who received adjuvant concurrent chemoradiation (CCRT) for high risk of treatment failure after...Full Text Available

2009-03-01

385

VOLUME I11 IMISSION SYSTEM PERFORMANCE - NASA Technical Report ...

Mar 1, 2011 ... Radionuclide X-ray fluorescence analysis. 2: Detection of the X-ray fluorescence radiation excited by radionuclide radiation ...

386

The importance of radiation quality for optimisation in radiology

Nov 8, 2010 ... Ihring Mission 11, the radiation dosimetry measurement system functioned normally and provided data on the Earth's trapped radiation belts ...

387

The biological aspects and behaviour of Heliothis virescens Fabricius adults from irradiated diapausal pupae

Selection of the appropriate radiation quality is an important aspect of optimisation for every clinical imaging task in radiology, since it affects both image quality and patient dose. Spreadsheet...Full Text Available

388

Tachyon Cerenkov radiation

... bollworm fertility gamma radiation genetic radiation effects life span mating

1974-07-22

389

Solar Cell Radiation Response near the Interface of Different ...

By proposing the four-dimensional, reciprocity transformations the appropriate condition for superluminal electromagnetic Cerenkov radiation is obtained by introducing the hypothesis that tachyons possess vector energy and scalar momentum.

1985-09-01

390

Relationship of Optical Coating on Thermal Radiation ...

... Solar Cell Radiation Respinnse Near the Interface o~f fliffprerv- ... 5 4. CALCUTl-ATED SOLAR CELL RLSPONSE FOR VARIOUS BASE MATERIALS ...

1971-11-01

391

References | Radiation Protection | US EPA

drical Enclosures Using a Numerical Ray Tracing Technique. NASA. TM-I02527, 1990 . Buckley, H.: Radiation from the Interior of a Reflecting Cylinder. Philos. ...

392

Radiation-response study of new radiation-hardened low-power TTL series

...References | Radiation Protection | US EPA This page provides links to the reference material on EPA's Radiation Protection Web site. U.S. EPA/...OAR/ORIA/Radiation Protection Division Jump to main content. Radiation Protection Contact Us Search: All EPA This Area You are here: EPA Home ... Radiation Protection References PageName Technical Users General Public Reporters Librarians Students/Teachers PROGRAMS TOPICS REFERENCES References The Reference Section provides general material that support the ...other sections of EPA's Radiation Protection Web site. You will find links within the information to related pages throughout the Radiation Protection , EPA ...

393

Radiation deamination of tetracycline. [Gamma radiation

(Dec 1971). United States Olson, RJ Alexander, DR Antinone, RJ Durham,

394

Radiation Damage Calculations for the FUBR and BEATRIX Irradiations of Lithium Compounds in EBR-II and FFTF

The fundamental product of tetracycline hydrochlorine gamma radiolysis was separated in its solid state. From the results of spectroscopic studies it has been established that it is des-N,N-dimethylaminotetracycline.

1980-01-01

395

Onclas U9800 - NASA Technical Report Server (NTRS)

Radiation Damage Calculations for the FUBR and BEATRIX Irradiations of Lithium Compunds in EBR-II and FFTF

1999-05-01

396

Numerical analysis of methane-air combustion considering radiation effect

the probability of its spontaneous radiation de-excitation increases. ... consider spontaneous radiation transitions. We will examine the ...

397

Numerical analysis of methane-air combustion considering radiation effect

Turbulent premixed methane-air combustion in a cylindrical chamber is numerically simulated considering radiation effect. Reaction rates are considered as minimum rates between Arrhenius rates and eddy break up rates. A five step reduced mechanism is used. Turbulent modeling is done via standard k-{epsilon} model imposed by empirical inlet boundary conditions. Source terms of energy equation consist of reaction rates and radiation effects. The discrete ordinate method (DOM) is employed to solve the radiative transfer equation (RTE) and the weighted sum of gray gas model (WSGGM) is imposed to consider radiation effect of non-gray gases. The results indicate that in the case of turbulent combusting flows, the effect of radiation of gases can affect the temperature and species concentrations. The numerical results obtained considering radiation effect are closer to ...

2008-12-15

398

Multifunctional, Boron-Foam Based Radiation Shielding

Turbulent premixed methane-air combustion in a cylindrical chamber is numerically simulated considering radiation effect. Reaction rates are considered as minimum rates between Arrhenius rates and eddy break up rates. A five step reduced mechanism is used. Turbulent modeling is done via standard k-? model imposed by empirical inlet boundary conditions. Source terms of energy equation consist of reaction rates and radiation effects. The discrete ordinate method (DOM) is employed to solve the radiative transfer equation (RTE) and the weighted sum of gray gas model (WSGGM) is imposed to consider radiation effect of non-gray gases. The results indicate that in the case of turbulent combusting flows, the effect of radiation of gases can affect the temperature and species concentrations. The numerical results obtained considering radiation effect are closer to the ...

2008-12-01

399

Mathematical Analysis of Three Free-Electron-Laser Issues

PROPOSAL NUMBER: 04 B3.09-7744. SUBTOPIC TITLE: Radiation Shielding to Protect Humans. PROPOSAL TITLE: Multifunctional, Boron-Foam Based ...

400

Equipment hardening and hardness assurance

... iFfficiency-en- enhanced spontaneous radiation at the free-electron- ... as enhanced spontaneous radiation at the free-electron-laser wavelength. ...

1990-09-30

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

Enhanced coherent undulator radiation from bunched electron beams

The introduction of tolerance to radiation (''radiation-hardness'') into large electronic systems is one of the major tasks to which this Handbook will be put. The practices recommended here for inculcating radiation-tolerance in equipment require advanced physical modeling techniques, precise engineering procedures, and firm assurance procedures. The degree to which these procedures should be used in an equipment project can be measured by the severity of the raw radiation environment, the desired reliability of the system, and the requirement of that project for radiation-sensitive technologies. The balance of device/circuit design versus shielding will depend on whether the radiation is highly penetrating -- as in isotope handling or military environments -- or readily attenuated, as in space. In this chapter the authors have attempted to summarize the ...

402

Effect of gamma radiation and bag packaging materials on the development of Dermestes maculatus De Geer (Coleoptera: Dermestidae) in sword fish

When energetic bunches of electrons traverse an undulator field, they can spontaneously emit radiation both coherently and incoherently. Although it has generally been assumed that undulator radiation is incoherent at wavelengths short compared to the longitudinal size of the electron bunch, several recent observations have proved this assumption false. Furthermore, the appearance of coherent radiation is often accompanied by a significant increase in radiated power. Here we report observations of strongly enhanced coherent spontaneous radiation together with direct measurements, using transition radiation techniques, of the electron distributions responsible for the coherent emission. We also report demonstrated enhancements in the predicted spontaneous radiated power by as much as 6x10"4 using electron bunch compression. copyright 1996 ...

1995-09-28

403

ESR study in radiation damage in pyrimidines. 3-year comprehensive progress report

... EFFECT OF GAMMA RADIATION AND BAG PACKAGING MATERIALS ON

1998-06-01

404

Differences in synchrotron radiation induced gas desorption from stainless steel and aluminium alloy

General mechanisms of radiation damage to biomolecules was studied by using substituted pyrimidines, particularly barbituric acid derivatives.

405

Chinese Journal of Lasers (Selected Articles)

Differences in synchrotron radiation induced gas desorption from stainless steel and aluminium alloy

1990-01-01

406

An evaluation of planning techniques for stereotactic body radiation therapy in lung tumors

... spontaneous radiation of amplifiers within a relatively w~de range of ... pulse widths are 20-30ns, while amplified spontaneous radiation pulse ...

1991-12-10

407

Study on dose distribution of therapeutic proton beams with prompt gamma measurement

PurposeTo evaluate four planning techniques for stereotactic body radiation therapy (SBRT) in lung tumors.Methods...Full Text Available

2008-04-01

408

Primary malignant lymphoma of the brain; Primaere maligne Lymphome des Gehirns

The proton beam has an advantage of the sharp dose falloff in dose distribution called Bragg peak while conventional radiation therapy modalities such as photons exhibit considerable amount of exit dose. To take advantage of this property it is important to know the exact location of the distal dose falloff. An error can cause overdose to the normal tissue or underdose to the tumor volume. The only way of finding out the dose distribution in-situ in particle therapy is to measure the gammas produced by nuclear reactions with tissue materials. Two kinds of gammas can be used: one is prompt gamma and the other is coincident gamma from the positron-emission isotopes. We chose to detect prompt gammas, and developed a prompt gamma scanning system (PGS). The proton beams of the proton therapy facility at National Cancer Center were used. The gamma distribution was compared to the dose distribution measured by an ionization chamber at three different energies of 100, 150, ...

2007-03-15

409

Monitoring of DNA and cytogenetic damage in lymphocytes from persons with skin cancer diseases

Primary malignant lymphoma of the brain is a disease of unknown etiology, which is increasing in incidence and has an unfavorable prognosis. Despite the lack of specific changes on CT or MRI in most cases, these procedures may typically facilitate the diagnosis: A focal-enhancing mass with subependymal spread on CT or MRI and hyperattenuation on nonenhanced CT are the most reliable features in the diagnosis of primary malignant lymphoma of the brain. Peritumoral edema and mass effect are usually not prominent features. On unenhanced CT scans they usually appear homogeneously isodense to mildly hyperdense relative to the gray matter. On MRI these tumors are slightly hypointense on T1-weighted images and slightly hpyerintense on PD- and T2-weighted images relative to the gray matter. On CT and MRI enhancement is usually homogeneous. Contrast-enhanced MRI, with its multiplanar capability, lack of bone-induced artifacts, and high-contrast resolution, is likely to reveal subependymal spread ...

1997-01-01

410

Characterization of an add-on multileaf collimator for electron beam therapy

There is a lot of interest in the studies that would help to understand whether there is a casual association between cancer and various types of molecular or cytogenetic damage detected in human cells. One major oncogenesis process is activation of proto-oncogenes by point mutations or chromosomal translocation. There are substantial evidence that indicates that the loss of heterozygosity of certain chromosomes is involved in human cancerogenesis. Our study aimed to elicit the possible association between cancer and DNA and cytogenetic abnormalities induced in lymphocytes of people bearing various categories of skin cancer cells. Fresh blood was collected by venipuncture from 25 individuals (including nine prior to cancer treatment). All patients were nonsmoking males, however 42.3 % of them were former smokers. Blood samples were divided into two parts and in the first part of samples cytogenetic studies were performed immediately, while from the second part ...

2004-11-01

411

A deterministic partial differential equation model for dose calculation in electron radiotherapy

An add-on multileaf collimator for electrons (eMLC) has been developed that provides computer-controlled beam collimation and isocentric dose delivery. The design parameters result from the design study by Gauer et al (2006 Phys. Med. Biol. 51 5987-6003) and were configured such that a compact and light-weight eMLC with motorized leaves can be industrially manufactured and stably mounted on a conventional linear accelerator. In the present study, the efficiency of an initial computer-controlled prototype was examined according to the design goals and the performance of energy- and intensity-modulated treatment techniques. This study concentrates on the attachment and gantry stability as well as the dosimetric characteristics of central-axis and off-axis dose, field size dependence, collimator scatter, field abutment, radiation leakage and the setting of the accelerator jaws. To provide isocentric irradiation, the eMLC can be placed either 16 or ...

2008-02-21

412

Workability and Heat Treatment Characteristics of Beta ...

High-energy ionizing radiation is a prominent modality for the treatment of many cancers. The approaches to electron dose calculation can be categorized into semi-empirical models (e.g. Fermi-Eyges, convolution-superposition) and probabilistic methods (e.g. Monte Carlo). A third approach to dose calculation has only recently attracted attention in the medical physics community. This approach is based on the deterministic kinetic equations of radiative transfer. We derive a macroscopic partial differential equation model for electron transport in tissue. This model involves an angular closure in the phase space. It is exact for the free streaming and the isotropic regime. We solve it numerically by a newly developed HLLC scheme based on Berthon et al (2007 J. Sci. Comput. 31 347-89) that exactly preserves the key properties of the analytical solution on the discrete level. We discuss several test cases taken from the medical ...

2010-07-07

413

Vascular Effects of Photodynamic and Pulsed Dye Laser Therapy Protocols

... Accession Number : ADD135317. Title : Workability and Heat Treatment Characteristics of Beta Titanium Alloy, Ti-15V-3Cr-3Sn-3Al,. ...

1986-04-01

414

The Epidemiology of Cosmetic Treatments for Corneal Opacities in a Korean Population

Background and ObjectivePulsed dye laser (PDL) treatment of cutaneous vascular lesions is associated with variable and unpredictable efficacy. Thus, alternative treatment...Full Text Available

2008-11-01

415

Photocatalytic oxidation and reduction chemistry and a new process for treatment of pink water and related contaminated water

PurposeTo describe etiologies and clinical characteristics of corneal opacities leading patients to seek cosmetic treatments.MethodsThe medical records...Full Text Available

2010-06-01

416

Peritonectomy procedures.

The objective of this project was to develop new photocatalytic or other innovative process chemistry for the treatment of pink water and related contaminated water.

1996-10-01

417

Morphine versus Mexiletine for Treatment of Postamputation Pain

OBJECTIVE: New surgical procedures designed to assist in the treatment of peritoneal surface malignancy were sought. BACKGROUND: Decisions regarding the treatment of cancer depend on the anatomic location...Full Text Available

1995-01-01

418

Local excision as a treatment for tumors of ampulla of Vater

BackgroundStump and phantom pains are debilitating sequelae of amputations that are often resistant to treatment. The efficacy of pharmacologic therapies, including...Full Text Available

2008-08-01

419

Lapses following Alcohol Treatment: Modeling the Falls From the Wagon*

BackgroundAlthough local excision (ampullectomy) was first described by Halsted in 1899, its adequacy as an alternative surgical treatment for the ampullary tumors is still a matter...Full Text Available

420

Influence of inflammation on the efficacy of antibiotic treatment of experimental pyelonephritis.

ObjectiveThis study investigated transitions between drinking and nondrinking during the first 12 months following treatment and whether transitions in posttreatment...Full Text Available

2008-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

421

Analysis of plasma treatment and vapor heat treatment for thin-film transistors by extracting trap densities at front and back interfaces

An acute exudative Escherichia coli pyelonephritis rat model was used to study the influence of progressive pyelonephritis on the efficacy of antibiotic treatment. In this model, transient ureteral...Full Text Available

1986-05-01

422

A fuel treatment reduces fire severity and increases suppression efficiency in a mixed conifer forest

Hydrogen (H) plasma treatment, oxygen (O) plasma treatment and water (H_2O)-vapor heat treatment for polycrystalline-silicon (poly-Si) thin-film transistors (TFTs) have been analyzed by separately extracting trap density at a front silicon-oxide interface (D_F) and trap density at a back interface (D_B). It is found that the H plasma treatment is apt to generate D_F and D_B. The O plasma treatment reduces D_F, while the H_2O-vapor heat treatment reduces both D_F and D_B. Improvement of transistor characteristics of poly-Si TFTs depends on understanding these results.

2004-05-17

423

HDR and MDR intracavitary treatment for carcinoma of the uterine cervix. A prospective randomized study

Fuel treatments are being implemented on public and private lands across the western United States. Although scientists and managers have an understanding ... ...

424

Actual and future strategies in interdisciplinary treatment of medulloblastomas, supratentorial PNET and intracranial germ cell tumors in childhood; Aktuelle und zukuenftige Strategien in der interdisziplinaeren Therapie von Medulloblastomen, supratentoriellen PNET und intrakraniellen Keimzelltumoren im Kindesalter

Aim: Treatment of carcinoma of the uterine cervix by remote afterloading brachytherapy has been accompanied with new isotopes having dose rates different from the classical low-dose rate (LDR) radium source. The dose rate conversion factor from LDR to high-dose rate (HDR) found to be around 0.54 in most studies. As regards medium-dose rate (MDR) brachytherapie, the published data are very few and the experience is still short. In this study the experience of Osaka University Hospital with micro-HDR-Selectron and Selectron-MDR, as a preliminary report of the clinical trial, is presented. Results: The 3-year survival and loco-regional control rates for both modalities were nearly equivalent (62% and 67% for HDR and 68% and 74% for MDR)(totally 45 patients). The cumulative rectal and bladder complication rates were the same in both groups (29% at 3 years), with only 1 patient (MDR-group) developed grade 3 rectal and bladder complication. In this study, point A dose ...

1997-03-01

425

Accuracy of patient dose calculation for lung IMRT: A comparison of Monte Carlo, convolution/superposition, and pencil beam computations

Methods: Systemic irradiation of neuroaxis is an essential part in the management of medulloblastoma, stPNET and intracranial germ cell tumors. The introduction of quality assurance programs in radiooncology assures a precise radiotherapy of target volumes and is a prerequisite to improve survival. Results: Hyperfractionated radiotherapy has the potential of increasing dose to tumor more safely without increasing the risk for late adverse effects. Pilot studies revealed excellent tumor control in medulloblastoma with acceptable acute toxicity and a long-term survival of up to 96%. In medulloblastoma stereotactic radiation techniques reveal an acceptable toxicity and promising results in tumor control in recurrent disease or as primary treatment. They are now part of future treatment protocols in case of persisting residual tumor. Radiotherapy alone in pure germinoma is continuously yielding high cure rates. In secreting ...

2001-09-01

426

uv photobiology: postreplication repair. [Escherichia coli, synchrotron radiation

The accuracy of dose computation within the lungs depends strongly on the performance of the calculation algorithm in regions of electronic disequilibrium that arise near tissue inhomogeneities with large density variations. There is a lack of data evaluating the performance of highly developed analytical dose calculation algorithms compared to Monte Carlo computations in a clinical setting. We compared full Monte Carlo calculations (performed by our Monte Carlo dose engine MCDE) with two different commercial convolution/superposition (CS) implementations (Pinnacle-CS and Helax-TMS's collapsed cone model Helax-CC) and one pencil beam algorithm (Helax-TMS's pencil beam model Helax-PB) for 10 intensity modulated radiation therapy (IMRT) lung cancer patients. Treatment plans were created for two photon beam qualities (6 and 18 MV). For each dose calculation algorithm, patient, and beam quality, the following set of clinically relevant dose-volume ...

2006-09-01

427

Water Concentration Dependent Photochemistry of Ketoprofen in Neutral Aqueous Solutions

The following topics are discussed: insertion of incorrect bases in DNA; ability of DNA polymerase to copy uv-irradiated DNA; role of enzymes in repair of DNA; effects of uv radiation on molecular weight of DNA; photoreactivation; repair of DNA in Escherichia coli and xp cells following uv radiation; and synchrotron radiation studies on DNA repair. (HLW)

1978-01-01

428

Use of cozilat preparation as enteral nutrition for patients with late radiation injuries of colon

... v. 1267(1) RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR

2010-08-06

429

Tumorigenic and tumoricidal actions of ionizing radiations

Short note.

1988-06-28

430

The influence of stray radiation on image quality

The book is divided into two approximately equal parts. The first four chapters are relatively lengthy and cover the basic principles of radiation biology, carcinogenesis and therapy, along with a brief introduction to radiological physics to orient the reader without background in this specialized related discipline. The remainder consists of twenty-four relatively brief chapters, each covering the radiation biology of a specific organ, tissue, or systems tissues, with emphasis on the tumorigenic and tumoricidal action of ionizing radiations.

1983-01-01

431

The influence of copper(II) on radiation-induced damages to DNA

The present state of knowledge on the influence of stray radiation on image quality and its physical description and quantification is summarized. Experimental results on the influence of physical parameters on the fraction of scattered radiation and the effect of scatter reduction by air gap technique and secondary radiation grids are committed. Open theoretical and practical problems and the limitations of common methods of scatter reduction are pointed out. (author).

432

The Effect of Radiated Electromagnetic Wave by Digital Modulation Signals on the Electronic Devices

Short communication. 5 refs., 2 figs.

1996-12-31

433

Surprising collectivity in neutron-rich iron isotopes

Full Text Available

2011-02-01

434

Surface radiation effects on natural convection cooling of discrete heat source in an open-top cavity

... VDPEAZ (Bonn 2010 issue) NUCLEAR PHYSICS AND RADIATION PHYSICS

2010-03-15

435

Sur face Modification of Ultra High Molecular Weight Polyethylene Films by UV/ozone Ir radiation

Short communication.

1995-08-14

436

Study of Heat Transfer Augmentation in a High-Temperature Field by a Radiation Promoter Generating a Secondary Flow

Full Text Available

2011-06-01

437

Space Radiation Detector with Spherical Geometry

Not Available

1999-01-01

438

Some methodological aspects of investigations into radiation hardening of WWER-type reactor vessels

A particle detector is provided, the particle detector including a spherical Cherenkov detector, and

2011-01-01

439

Solar Radiation Pressure Binning for the Geosynchronous Orbit

Short communication.

1992-10-27

440

Self-filling and self-purging apparatus for detecting spontaneous radiation from substances in fluids

Orbital maintenance parameters for individual satellites or groups of satellites have traditionally

2011-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

Role of hormone and nutrition in radiation-induced rat mammary carcinogenesis

Disclosed herein is a radiation detector providing for the in situ automatic sampling of fluids containing substances emitting radiation, especially Cerenkov radiation. The detector permits sampling within well casings and is self-purging such that no additional provisions must be established for the storage and disposal of contaminated fluids.

1993-01-01

442

Radiological equipment for emergencies

Published in summary form only.

443

Radiative processes as a condensation phenomenon and the physical meaning of deformed canonical structures

A brief guide to training and equipment needed to effectively manage victims of radiation accidents. (DT)

1985-01-01

444

Radiative Heat Transfer Augmentation in Gas-Fired Radiant Tube Burners by Porous Inserts: Effect of Insert Geometry

No abstract prepared.

2008-07-01

445

Radiation-induced OH radical generation and its use for groundwater remediation

Not Available

1993-07-01

446

Radiation-annealing hardening of vanadium

Short communications only.

1992-09-13

447

Radiation processing used in forestry in Thailand

A study is made of the mechanical properties of vanadium irradiated with fast neutrons up to dose 8.6.10"-"4 dpa, as a function of the temperature of post-radiation annealing. The radiation-annealing hardening (RAH) effect is observed at 300"oC, in agreement with previous studies. It is established for the first time that RAH is accompanied by fall in ductility. A phenomenological model is described which explains the dependence of RAH on radiation dose and temperature, as well as on the content of chemically active alloying impurities. (author).

448

Radiation effects on the shoot tip culture of chrysanthemum

A summary is presented of research being carried out in Thailand on the preparation of irradiation-impregnated wood.

1981-01-01

449

Radiation cryochemistry of glass water; Kriochemia radiacyjna zeszklonej wody

Japanese (Mar 1974). Japan Mabuchi, Toshio Kuwada, Hikaru . Kagawa Univ.,

450

Radiation assessment of contaminated sites of peat mining and peat bricks used as fuel by the population of Zhitomir area of the Ukraine

Short communication. 4 refs.

1996-12-31

451

Radiation and fetal brain development

Short communication.

452

Radiation Protection of the Organism (Selected Chapters)

(4 Sep 1986). United Kingdom Zamenhof, Stephen . California Univ., Los

453

Quantum theory of spontaneous radiation by relativistic channeled particles

... biologically important compounds is sharply lowered with passage of the solutions to the cell an organ, where their sensitivity ...

1970-12-11

454

Quality Assurance of Intensity Modulated Radiation Therapy: Site-Specific Results of Eulji University Hospital

1977. USSR Beloshitsky, VV Kumakhov, MA Wedell, R. Moskovskij

1977-09-23

455

Possibility of production of new superheavy nuclei in complete fusion reactions

Full Text Available

2011-06-01

456

Nuclear physics with a free electron laser

... of Sciences (Poland) [5.48 Megabytes] NUCLEAR PHYSICS AND RADIATION

2008-09-01

457

N=2 supersymmetric radiation damping in an external electromagnetic field, noncommutativity and duality

... radiation parity photonuclear reactions polarized beams resonance

458

Multi-spectral schottky barrier infrared radiation detection array

No abstract prepared.

2008-07-01

459

Multi-spectral schottky barrier infrared radiation detection array

A multi-spectral Schottky barrier infrared detector array in which individual pixels of radiation from a remote radiating object are detected by two or more Schottky barrier infrared radiation detectors each having a different spectral response so as to provide a ''color'' discrimination for the array.

1983-12-27

460

Linearization of nondestructive radiation testing instruments using television technique

A multi-spectral Schottky barrier infrared detector array in which individual pixels of radiation from a remote radiating object are detected by two or more Schottky barrier infrared radiation detectors each having a different spectral response so as to provide a ''color'' discrimination for the array.

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

Kinetics of low-temperature radiation hardening of metallic materials under irradiation

(1985). USSR Nedavnij, OI Tomskij Politekhnicheskij Inst. (USSR).

462

British Library Electronic Table of Contents (United Kingdom)

A formula is obtained which describes the kinetics of low-temperature radiation hardening caused by creation of dislocation loops of interstitial type during irradiation. The radiation hardening of aluminum and vanadium is estimated using this formula and results of experiments on studying processes of nucleation and growth of interstitial dislocation loops in these materials by transparent electron microscopy. It is shown that the proposed formula is valid for description of the kinetics of low-temperature radiation hardening.

2011-01-01

463

Investigations and development of gaseous radiation detectors; Badania i rozwoj konstrukcji gazowych detektorow promieniowania

Infrared processes in the auroral zone

No abstract prepared

1998-12-31

464

Influence of production technology and irradiation conditions on radiation hardening of reactor vessel steels

... aurorae carbon dioxide emission spectra infrared radiation nitrogen nitrogen

8432-01-01

465

Induced radiation during scattering of channeled electrons and positrons by point defects

Short communication.

1992-10-27

466

Individually adapted examination protocols for reduction of radiation exposure in chest CT

In scattering of channeled particles by point defects and in emission of gamma rays in the spontaneous-radiation spectral region conditions are attained where the momentum transferred to the defect is taken up by the crystal as a whole. This leads to coherent and interference effects in the radiation from the crystal defects. When the longitudinal momentum transferred is zero, an induced radiation effect appears in the transitions between the states of transverse motion.

1984-12-01

467

Improvement of the Radiation Efficiency for a CPW(Co-Planar Waveguide)-Fed ZOR(Zeroth-Order Resonant) Antenna

No abstract prepared.

2002-02-01

468

Ignition and Flame Propagation of Solid Fuel with Radiation Effect in a Cylindrical Combustor

Full Text Available

2011-01-01

469

Full Text Available

2001-02-01

470

ISR site

Free radicals in lysozyme reacted with peroxidizing methyl linoleate

A last look at the green field, in the triangular wedge of land stray radiation near the CERN accelerators.

1965-01-01

471

Four cases of bowel perforation following radiation therapy for cervical cancer

... electron spin resonance gamma radiation lipids lyophilization lysozyme radicals

472

Experts' discussion on the possibility of quantification of the radiation hazard

External radiation dose exceeded 5,000 rad in three cases, and intravaginal radiation dose was 5,000 rad in one case. Radiation damage including perforation was seen in the end of ileus in one case, in the sigmoid and rectum in two cases, and in the end of ileus, sigmoid and rectum in the last case. Satisfactory results were obtained by the removal of the ileocecum in the case of the damage in the end of the ileus. However, only colostomy was performed for the damage in the sigmoid and rectum.

1984-10-01

473

Establishment of Short-Term Teratogenicity Study for Detecting Developmental Toxicity Induced by Gamma Radiation

Due to the intensity and vast number of subjects, this Bremen experts' discussion, too, could discuss only part of the problem of the possibilitiy to quantify the radiation hazard. One preliminary result is that there is no scientific proof of the harmlessness of radiation exposure during normal operation of a nuclear power plant, either within the plant or in its vicinity. Other results are that some important questions can not be answered yet, and that there are important hints on the dangers even of low radiation doses. (GL).

1978-01-01

474

Effective dose equivalent in nuclear medicine investigations

Full Text Available

2004-06-01

475

Differentiation between brain tumor recurrence and radiation injury using perfusion, diffusion-weighted imaging and MR spectroscopy.

... radiation hazards hazards health hazards MEDICINE. SOMATICALLY

1984-05-07

476

Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy.

PMID:20602289

2010-01-01

477

Development of a real-time, neutron and gamma dosimeter

PMID:16304000

2005-12-01

478

Development of a real-time, neutron and gamma dosimeter

In 1998, research began at Idaho National Engineering and Environmental Laboratory to investigate the application of {sup 6}Li and {sup 7}Li isotopes to the measurement of neutron and gamma radiation. Various size pairs of {sup 6}Li and {sup 7}Li based detectors were exposed to mixed neutron and gamma radiation. Experiments demonstrated that these detectors could be used to measure low level neutron radiation in the presence of high level gamma radiation. (author)

2001-07-01

479

Cooperative spontaneous emission from two different atoms

In 1998, research began at Idaho National Engineering and Environmental Laboratory to investigate the application of "6Li and "7Li isotopes to the measurement of neutron and gamma radiation. Various size pairs of "6Li and "7Li based detectors were exposed to mixed neutron and gamma radiation. Experiments demonstrated that these detectors could be used to measure low level neutron radiation in the presence of high level gamma radiation. (author)

2001-06-10

480

Comparison between DNA damage investigated by the ''Comet'' assay and chromosomal damage induced in human lymphocytes by radiation and chemicals

The total radiation rate, angular distribution of the emitted energy and photon correlations of the cooperative spontaneous radiation from two atoms with different resonance frequencies and spontaneous decay rates are calculated. Contrary to the case of two identical atoms oscillations appear in the total radiation rate and the spatial distribution of the total number of emitted photons differs from the single-atom radiation pattern. The effect of the dipole-dipole near-field interaction on the time evolution of the atomic system is discussed. (author).

1986-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

481

Cluster-loop structure influence on molybdenum radiation hardening

Short communication.

1995-08-20

482

Characteristics of Radiated Electromagnetic Wave and Partial Discharge in Power XLPE Cable

Results on defect structure study and degree of molybdenum radiation hardening irradiated by fission neutrons and medium energy alpha-particles are presented. It is shown that molybdenum irradiation by alpha-particles and neutrons leads to different degree of material hardening for the same damage level. It is established that molybdenum radiation hardening is mainly defined by radiation defect clusters visible in electron microscope whose coefficient of rigidity depends on their size. 5 refs.; 6 figs.; 2 tabs. (author).

1990-05-22

483

Bulgarian population exposure resulting from diagnostic nuclear-medicine applications

Full Text Available

2004-09-01

484

Behavior study of polyphenols from Maytenus aquifolium due to X and gamma radiations

... populations radiation doses RADIOACTIVE MATERIALS. SOMATICALLY

1980-10-26

485

An Analysis of Vibration and Sound Radiation of Sandwich Panels Using the Rayleigh-Ritz Method

Short communication.

1995-09-03

486

Action of the venom of Apis mellifera and gamma radiation on mammalian cells

Full Text Available

2011-05-01

487

Published in summary form only.

1988-07-01

488

About tachyons

... Part A: The electromagnetic radiation of a charged tachyon. Part B: Some

489

ASE FILE

A Numerical Model of an Edge-clamped Rectangular Plate Based on a Mode Method to Predict Acoustic Radiation Characteristics

radionuclide X-ray fluorescence analysis: the resolving power of the ... The radiation detectors used in radionuclide X-ray fluorescence ...

490

Full Text Available

2011-04-01

491

Theory of edge radiation

Radiative corrections to the atomic levels in a periodic electromagnetic field

We formulate a complete theory of Edge Radiation based on a novel method relying on Fourier Optics techniques. Similar types of radiation like Transition Undulator Radiation are addressed in the framework of the same formalism. Special attention is payed in discussing the validity of approximations upon which the theory is built. Our study makes consistent use of both similarity techniques and comparisons with numerical results from simulation. We discuss both near and far zone. Physical understanding of many asymptotes is discussed. Based on the solution of the field equation with a tensor Green's function technique, we also discuss an analytical model to describe the presence of a vacuum chamber. In particular, explicit calculations for a circular vacuum chamber are reported. Finally, we consider the use of Edge Radiation as a tool for electron beam diagnostics. We discuss Coherent Edge ...

2008-01-01

492

Biological radiation effects

The influence of a periodic electromagnetic field on the radiative corrections to the atomic energy levels is studied for the case of ''strong fields'' for which the interaction between the atom and field is of the order or greater than the radiative effects. The analysis is carried out on the basis of the Schwinger-Dirac equation for the propagation function of a bound electron in the field and on the basis of the density matrix in the Furry representation. It is shown that in the strong field approximation the radiative shifts and widths are manifest as radiative corrections to the quasi-energies. In super-high resolution experiments intensity effects in the radiative corrections to the atomic levels are obtained in the case of single-photon resonance. Some multiphoton processes are condidered by taking into account the effect of the field on ...

1982-12-01

493

A study on the real-time radiation dosimetry measurement system based on optically stimulated luminescence

The stages of processes leading to radiation damage are studied, as well as, the direct and indirect mechanics of its production. The radiation effects on nucleic acid and protein macro moleculas are treated. The physical and chemical factors that modify radiosensibility are analysed, in particular the oxygen effects, the sensibilization by analogues of nitrogen bases, post-effects, chemical protection and inherent cell factors. Consideration is given to restoration processes by excision of injured fragments, the bloching of the excision restoration processes, the restoration of lesions caused by ionizing radiations and to the restoration by genetic recombination. Referring to somatic effects of radiation, the early ones and the acute syndrome of radiation are discussed. The difference of radiosensibility observed in mammalian cells and main observable alterations in tissues and ...

1976-01-01

494

Simulation for position determination of distal and proximal edges for SOBP irradiation in hadron therapy by using the maximum likelihood estimation method

The optically stimulated luminescent (OSL) radiation dosimeter technically surveys a wide dynamic measurement range and a high sensitivity. Optical fiber dosimeters provide capability for remote monitoring of the radiation in the locations which are difficult-to-access and hazardous. In addition, optical fiber dosimeters are immune to electrical and radio-frequency interference. In this paper, a novel remote optical fiber radiation dosimeter is described. The optical fiber dosimeter takes advantage of the charge trapping materials CaS:Ce, Sm that exhibit OSL. The measuring range of the dosimeter is from 0.1 to 100 Gy. The equipment is relatively simple and small in size, and has low power consumption. This device is suitable for measuring the space radiation dose and also can be used in high radiation dose condition and other dangerous radiation occasions. ...

2008-05-01

495

Inherited sterility progeny gamma irradiated male Spiny Bollworm Earias Insulana Boisd

In radiation therapy with hadron beams, conformal irradiation to a tumour can be achieved by using the properties of incident ions such as the high dose concentration around the Bragg peak. For the effective utilization of such properties, it is necessary to evaluate the volume irradiated with hadron beams and the deposited dose distribution in a patient's body. Several methods have been proposed for this purpose, one of which uses the positron emitters generated through fragmentation reactions between incident ions and target nuclei. In the previous paper, we showed that the maximum likelihood estimation (MLE) method could be applicable to the estimation of beam end-point from the measured positron emitting activity distribution for mono-energetic beam irradiations. In a practical treatment, a spread-out Bragg peak (SOBP) beam is used to achieve a uniform biological dose distribution in the whole target volume. Therefore, in the ...

2005-12-21

496

Heavy fuel oil combustion in a cylindrical laboratory furnace: measurements and modeling

The present work studies the fecundity, egg batching and mating of normal females of Earias Insulana Boisd. crossed with males irradiated as 24 h adult moths with two doses (80 and 100 Gy.) of gamma radiation. The male progeny were out bred or inbred with untreated individuals for two successive generations F_1and F_2 and their progeny was observed for any inherited deleterious effects on reproduction. The female fecundity and egg hatch were significantly reduced among P1,F1 and F2 generations by increasing the dosages applied to P_1 males as compared with the untreated control. The percentage of mating of P_1 females was significantly reduced at the two doses as compared to the untreated control. The average number of spermatophores per mated female was reduced among P_1,F_1 and F_2 generations when parental males were irradiated with 100 Gy. The larval and pupal mortality a,o mg F_1, F_2 and F_3 generations was high and dose dependent. The average developmental ...

2003-01-01

497

Floating zone crystal growth of selected R2PdSi3 ternary silicides

The finite-volume based commercial CFD-code Fluent was used to simulate the reacting flow in a heavy fuel oil fired laboratory furnace. Both the standard {kappa}-{epsilon} turbulence model and the Reynolds stress model (RSM) were tested. The combustion model was based on the conserved scalar (mixture fraction) and prescribed probability density function approach. The heavy fuel oil droplet trajectories were predicted by solving the momentum equations for the droplets using the Lagrangian treatment. The soot distribution in the furnace was calculated by solving a transport equation for the soot mass fraction. Simple expressions for the soot formation and oxidation rates were employed. The radiation heat transfer equation was solved using the finite volume method. The formation of thermal NO from molecular nitrogen was modeled according to the extended Zeldovich mechanism. Fuel-based NO was modeled assuming that all the nitrogen in the fuel is ...

2005-03-01

498

Combined photochemical-biological processes for treatment of unleaded gasoline oxygenates : MTBE, ETBE and TAME

Substitution of various rare earths R within the class of R2PdSi3 single crystals with hexagonal AlB2-type crystallographic structure reveals the systematic dependence of anisotropic magnetic properties governed by the interplay of crystal-electric field effects and magnetic two-ion interactions. Here we compare the floating zone (FZ) crystal growth with radiation heating of compounds with R = Tb, Tm, Pr, and Gd. The congruent melting behavior enabled moderate growth velocities of 3 to 5 mmh-1. The preferred growth directions are close to the basal plane of the hexagonal unit cell. The composition of the crystals, except of Tb2PdSi3, is slightly Pd-depleted with respect to the nominal composition 16.7 at.% Pd. Thin precipitates of RSi secondary phases were detected in the crystal matrix. Their phase fraction can be diminished by growth from Pd-rich melt compositions and annealing treatments. The compounds exhibit antiferromagnetic order below ...

2011-06-01

499

A case of wound intake of plutonium isotopes and 241Am in a human: application and improvement of the NCRP wound model.

A study was conducted to determine the feasibility and the opportunity of photochemical pretreatment on the biodegradation and detoxification of Methyl Tert Butyl Ether (MTBE), Ethyl Tert Butyl Ether (ETBE) and Tert Amyl Methyl Ether (TAME), the most common oxygenates used as octane enhancers in unleaded gasoline. The production, storage, uses and disposal of oxygenates result in an unknown amount of groundwater pollution. Because of their high solubility, MTBE, ETBE and TAME are detected in large portions in saturated zones of aquifers. The biodegradation of these oxygenates is difficult and slow, and information regarding their biodegradability is scarce. Photo-decomposition of oxidants under appropriate UV radiation has been shown to be very effective because the hydroxyl radicals produced possess high oxidation potential. In this study, the H_2O_2/UV process was used to generate hydroxyl radicals. Maximal oxygenates transformation was obtained in a few minutes. ...

1998-10-01

500