The transformation of two different types of glialcells has been studied using an in vivo-/in vitro model and a complete in vitro model. The purpose of the study and to define in vitro model systems is to study the the neoplastic transformation of pure populations of glialcells. Data are presented to demonstrate that the transformed cells are glial and tumorigenic. (ACR)
BackgroundThe dynorphin-kappa opioid receptor (KOR) system regulates glial proliferation after sciatic nerve injury. Here, we investigated its role in cell proliferation following...Full Text Available
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the JC virus (JCV), a human papovavirus. PML is a relatively rare disease seen predominantly in immunocompromised individuals and is a frequent complication observed in AIDS patients. The significantly higher incidence of PML in AIDS patients than in other immunosuppressive disorders has suggested that the presence of human immunodeficiency virus type 1 (HIV-1) in the brain may directly or indirectly contribute to the pathogenesis of this disease. In the present study the authors have examined the expression of the JCV genome in both glial and non-glialcells in the presence of HIV-1 regulatory proteins. They find that the HIV-1-encoded trans-regulatory protein tat increases the basal activity of the JCV late promoter, JCV{sub L}, in glialcells. They conclude that the ...
Acute inflammation is important for tissue repair; however, chronic inflammation contributes to neurodegeneration in Alzheimer’s disease (AD) and occurs when glialcells undergo prolonged...Full Text Available
Astrocytes have long been perceived only as structural and supporting cells within the central nervous system (CNS). However, the discovery that these glialcells may potentially express receptors capable...Full Text Available
Candoxin (PDB #1JGK), a three-finger neurotoxin from Bungarus candidus venom, inhibits post-synaptic neuromuscular and neuronal alpha7nACh-receptors, and induces delayed cell-death throughout the glial population. When applied to cultured human glialcell lines, candoxin (CDX) induced cell death in a concentration (EC(50) approximately 1muM) and time dependent manner. Results of TUNEL-histochemistry further confirm CDX-induced brain (hippocampus, frontal cortex, and temporal regions) damage when administered intracerebroventricularly (i.c.v) in adult mice. In this study, we explored differential gene expression profiles following exposure of human glial (Hs 683) cell lines to CDX at various time intervals using Affymetrix-GeneChips. By means of MAS and GeneSpring analyses, 105 genes whose expression was significantly (P<0.01) altered by ...
The efficient use of the fuel is one of the objectives in the assemblies design of type BWR. The present tendency in the assemblies design of type BWR is through a radial distribution of enrichments. The present work has like object showing the because of this decision, for what a comparison of the neutronic performance of two fuel cells with the same enrichment average but one of them with radial distribution of enrichment and the other with a single enrichment equal to the average. The cells were analyzed with the CASMO-4 code and the obtained results of the behavior of the neutron flow and the power sustain the because of the radial distribution of enrichments. (Author)
Nitric oxide (NO) is a gas produced through the action of nitric oxide synthase that acts as a neurotransmitter in the central nervous system (CNS) of adult gastropod mollusks. There are no known reports of the presence of NOS-containing neurons and glialcells in young and adult Megalobulimus abbreviatus. Therefore, NADPH-d histochemistry was employed to map the nitrergic distribution in the CNS of young and adult snails in an attempt to identify any transient enzymatic activity in the developing CNS. Reaction was observed in neurons and fibers in all CNS ganglia of both age groups, but in the pedal and cerebral ganglia, positive neurons were more intense than in other ganglia, forming clusters symmetrically located in both paired ganglia. However, neuronal NADPH-d activity in the mesocer...
Abstract in english Cytokines are molecules that were initially discovered in the immune system as mediators of communication between various types of immune cells. However, it soon became evident that cytokines exert profound effects on key functions of the central nervous system, such as food intake, fever, neuroendocrine regulation, long-term potentiation, and behavior. In the 80's and 90's our group and others discovered that the genes encoding various cytokines and their receptors are e (more) xpressed in vascular, glial, and neuronal structures of the adult brain. Most cytokines act through cell surface receptors that have one transmembrane domain and which transduce a signal through the JAK/STAT pathway. Of particular physiological and pathophysiological relevance is the fact that cytokines are potent regulators of hypothalamic neuropeptidergic systems that maintain neuroendocrine homeostasis and which regulate the ...
Spherical aggregates formed rapidly in culture by re-aggregation of trypsin-dissociated brain cells from the 17-day-old fetal rat. Over about 10 days an initially random distribution of cells evolved into a 3-layered arrangement; cells with characteristics of neurons were found largely in the intermediate layer. The survival of neuronal and glialcell types was evaluated histologically and verified by electron microscopy, which revealed synaptic and myelin structures that rapidly increased in number after 18 days in culture. Levels of norepinephrine (NE) and dopamine (DA) reached peaks of 9.5 and 4.4 ng/mg protein, respectively, at culture day 21. Uptake of ["3H]NE paralleled these amine levels and was blocked by desipramine or pretreatment with either reserpine or 6-OH-DA. Autoradiographs of aggregates labeled with ["3H]NE showed a high density of silver grains over ...
Neonatal bacterial infection in rats alters the responses to a variety of subsequent challenges later in life. Here we explored the effects of neonatal bacterial infection on a subsequent drug...Full Text Available
BackgroundApolipoprotein E (ApoE), a cholesterol carrier associated with atherosclerosis, is a major risk factor for Alzheimer's disease (AD). The low-density lipoprotein receptor...Full Text Available
BackgroundMethamphetamine (METH), an addictive psycho-stimulant drug with euphoric effect is known to cause neurotoxicity due to oxidative stress, dopamine accumulation and glial...Full Text Available
In multiple sclerosis (MS), oligodendrocyte and myelin destruction lead to demyelination with subsequent axonal loss. Experimental demyelination in rodents has highlighted the activation of the subventricular...Full Text Available
Early white matter (WM) injury affects brain maturation in preterm infants as revealed by diffusion tensor imaging and volumetric magnetic resonance (MR) imaging at term postmenstrual age (PMA). The aim of the study was to assess quantitatively brain maturation in preterm infants with and without milder forms of WM damage (punctate WM lesions, PWML) using conventional MRI. Brain development was quantitatively assessed using a previously validated scoring system (total maturation score, TMS) which utilizes four parameters (progressive myelination and cortical infolding, progressive involution of glialcell migration bands and germinal matrix tissue). PWML were defined as foci of increased signal on T1-weighted images and decreased signal on T2-weighted images with no evidence of cystic degeneration. A group of 22 preterm infants with PWML at term PMA (PWML group) were compared with 22 matched controls with a normal MR appearance. The two groups ...
A cell calculation code SLAROM-UF was developed to improve calculation accuracy of effective cross sections for various fast reactor types. SLAROM-UF has a capability to calculate effective cross sections in ultra fine groups of about 100,000 below 50keV and in fine groups above the energy (maximum 900 groups). Resonance interaction among the fuel, the coolant, and the structure materials can be treated accurately even in a heterogeneous cell structure. Temperature can be set up freely in a cell by the ultra fine group calculation. Improvement in nuclear characteristics was observed in the analysis of JUPITER critical experiment, as 0.1% for criticality, 4% for sodium void reactivity, several % for radial reaction rate distribution, when SLAROM-UF was used instead of the typical cell calculation code. The effect of the ultra fine group calculation is remarkable in the non-leakage ...
Precocious puberty is a significant child health problem, especially in girls, because 95% of cases are idiopathic. Our earlier studies demonstrated that low-dose levels of manganese (Mn) caused precocious puberty via stimulating the secretion of luteinizing hormone-releasing hormone (LHRH). Because glial-neuronal communications are important for the activation of LHRH secretion at puberty, we investigated the effects of prepubertal Mn exposure on specific glial-derived puberty-related genes known to affect neuronal LHRH release. Animals were supplemented with MnCl2 (10 mg/kg) or saline by gastric gavage from day 12 until day 22 or day 29, then decapitated, and brains removed. The site of LHRH release is the medial basal hypothalamus (MBH), and tissues from this area were analyzed by real-...
The objective of this study is to develop an artificial neural network (ANN) model to predict the thermal conductivity of ethylene glycol-water solutions based on experimentally measured variables. The thermal conductivity of solutions at different concentrations and various temperatures was measured using the cylindrical cell method that physical properties of the solution are being determined fills the annular space between two concentric cylinders. During the experiment, heat flows in the radial direction outwards through the test liquid filled in the annual gap to cooling water. In the steady state, conduction inside the cell was described by the Fourier equation in cylindrical coordinates, with boundary conditions corresponding to heat transfer between the solution and cooling water. ...
Within the framework of the EFTTRA cooperation between CEA, ECN, EDF, FZK, IAM and ITU, six metallic {sup 99}Tc rods have been irradiated in the Petten HFR for 193 effective full power days. During this irradiation, more than 6% of the {sup 99}Tc has been transmuted to the stable {sup 100}Ru. At ECN, one of the six rods has been examined in the hot cell laboratory. The ruthenium concentration in the rod measured by Isotope Dilution Mass Spectrometry reaches 6.4% at 5 mm from the bottom of the rod and 6.0% at 5 mm from the top. Also the axial and radial distributions of the ruthenium have been measured by Electron Probe Micro Analysis. The ruthenium concentrations calculated by the three-dimensional Monte Carlo code KENO reach 6.1% at 5 mm from the bottom of the rod and 5.7% at 5 mm from the top. These values are in reasonable agreement with the measured ones. However, the calculated radial distribution of the ruthenium ...
Sex steroids and thyroid hormones play a key role in the development of the central nervous system. The critical role of these hormonal systems may explain the sensitivity of the hypothalamus, the cerebral cortex, and the hippocampus to endocrine-disrupting chemicals (EDC). This review examines the evidence for endocrine disruption of glial-neuronal functions in the hypothalamus, hippocampus, and cerebral cortex. Focus was placed on two well-studied EDC, the insecticide dichlorodiphenyltrichloroethane (DDT) and polychlorinated biphenyls (PCB). DDT is involved in neuroendocrine disruption of the reproductive axis, whereas polychlorinated biphenyls (PCB) interact with both the thyroid hormone- and sex steroid-dependent systems and disturb the neuroendocrine control of reproduction and develo...
The objective of this study is to develop an artificial neural network (ANN) model to predict the thermal conductivity of ethylene glycol-water solutions based on experimentally measured variables. The thermal conductivity of solutions at different concentrations and various temperatures was measured using the cylindrical cell method that physical properties of the solution are being determined fills the annular space between two concentric cylinders. During the experiment, heat flows in the radial direction outwards through the test liquid filled in the annual gap to cooling water. In the steady state, conduction inside the cell was described by the Fourier equation in cylindrical coordinates, with boundary conditions corresponding to heat transfer between the solution and cooling water. The performance of ANN was evaluated by a regression analysis between the predicted and the experimental values. The ANN predictions ...
The TRAC/PFI-MOD2 Version 5.3 code was assessed against six FLECHT-SEASET forced reflood tests (31504, 31203, 31302, 31701, 34209, and 31922) and two cylindrical core test facility (CCTF) tests [C1-19 and C2-6]. The objective of this study was to evaluate the clad thermal response predictive capabilities of the code with the newly added reflood model under large-break loss-of-coolant accident (LOCA) conditions in a pressurized water reactor (PWR). The TRAC model for the FLECHT-SEASET test facility was developed from a RELAP5 model. The test section was modeled using a vessel component with 23 axial levels, 1 radial ring, and 1 azimuthal cell. Test inlet and exit conditions were modeled using fill and break components, respectively. The measured lower and upper plenum test conditions were input to the model. The electrically heated rod was modeled using a rod component with 22 axial mesh points. The axial boundary of each mesh point coincided ...
A single radial hemolysis test was developed for quantitation of specific antibody to non-hemagglutinating viruses. With the human coronaviruses as models, this test utilizes the binding properties...Full Text Available
Background and purposeRadial head fractures are common, and may be associated with other injuries of clinical importance. We present the results of a standard additional MRI scan...Full Text Available
The influence of geometry and operating conditions of the centrifugal compressor stage on the radial gas force is determined on the basis of the theoretical method and calculation program using experimental boundary conditions.
An earlier representation of the radial distribution of dose about the path of a heavy ion in liquid water is modified and extended to include silicon, lithium fluoride, and sodium iodide. 6 refs., 5 figs., 1 tab.
A radial-flow type internally oil-cooled oil-filled cable has been developed. This system is characterized in that the oil flows radially through the paper insulation. The thermal resistance of the insulation is equivalently decreased by the radial-flow. The decreased thermal resistance as well as the cooling effect of the oil flow in the central oil duct and the outer oil duct under an aluminum sheath increase the current capacity. A calculation method of cooling characteristics is introduced. The stability of the cable and accessories was confirmed through initial electrical tests and a long-term field test.
The He-shell flash convection in AGB stars is the site for the high-temperature component of the s-process in low- and intermediate mass giants, driven by the Ne22 neutron source. [...] The upper convection boundary plays a critical role during the H-ingestion episode that may lead to neutron-bursts in the most metal-poor AGB stars. We address these problems through global 3-dimensional hydrodynamic simulations including the entire spherical He-shell flash convection zone (as oposed to the 3D box-in-a-star simulations). An important aspect of our current effort is to establish the feasibility of our appoach. We explain why we favour the explicit treatment over the anelastic approximation for this problem. The simulations presented in this paper use a Cartesian grid of 512^3 cells and have been run on four 8-core workstations for four days to simulate ~5000s, which corresponds to almost ten convective turn-over times. The convection layer extends ...
Uranium enrichment by gas centrifugation relies on the pressure diffusion of the isotopes when their gaseous mixture is submitted to the pressure diffusion in the strong radial pressure gradient due to the centrifugal force in a very rapidly rotating cylinder. To compute the isotope separation in a gas centrifuge, the viscous compressible Navier-Stokes equations are solved for the mixture, then the diffusion equations are solved for the isotopes. As far as the separation performance is concerned, the models deal with the steady state of the axi-symmetric gas motion in the rotating cylinder. The numerical tools are briefly presented: first, the MOLINA code which numerically solves the axi-symmetric gas motion in the specific conditions of rapid rotation by use of a change of variables suited to the high density gradient and by use of a Marker And Cell method; then, the diffusion equations solver which uses a Finite Volume method with a mesh ...
We have performed precision measurements in a magneto-optical trap of the 7P1/2 hyperfine structure of the isotopes 209-210Fr. The ratio of these hyperfine constants to the previously measured 7S1/2 ground state values reveals a significant hyperfine anomaly. This anomaly results from the different radial dependence of the electron density in the two atomic levels. The measurements are sensitive to changes in the radial distribution of the neutron magnetism.
The radial distribution function (RDF) derived from wide angle X-ray diffraction patterns gives additional information about the spatial distribution of atoms. Their radial distances and relative average coordination numbers can be calculated using appropriate mathematical procedures. 7 refs.
This document is divided in two parts. The first part deals with the radial velocities (RV) distributions for B-type stars and nebulosities observed with the VLT-GIRAFFE in the Large and Small Magellanic Clouds towards the open clusters NGC2004 and NGC330. Thanks to the resolution of GIRAFFE spectra, we found that the RV distribution for the nebulosities in the LMC is bi-modal. This bi-modality can be interpreted, in term of dynamics, by the expansion of the LMC4 superbubble. The second part deals with the GAIA space mission and the determination of the radial velocities by using Radial Velocity Spectrometer (RVS) spectra. The methods to determine the radial velocities are presented as well as preliminary results on simulated RVS spectra.
The Monte-Carlo method and experimental methods were used to determine the neutron fluxes in the irradiation channels of the Ghana Research Reactor -1. The MCNP5 code was used for this purpose to simulate the radial and axial distribution of the neutron fluxes within all the ten irradiation channels. The results obtained were compared with the experimental results. After the MCNP simulation and experimental procedure, it was observed that axially, the fluxes rise to a peak before falling and then finally leveling out. Axially and radially, it was also observed that the fluxes in the centre of the channels were lower than on the sides. Radially, the fluxes dip in the centre while it increases steadily towards the sides of the channels. The results have shown that there are flux variations within the irradiation channels both axially and radially. (au)
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature astrocytes, but also an important component of the cytoskeleton in astrocytes during development. Major recent developments in astrocyte biology and the discovery of novel intermediate filament functions enticed the interest in the function of GFAP. The discovery of various GFAP splice variants gave an additional boost to explore this protein in more detail.The structural role of GFAP in astrocytes has been widely accepted for a long time, but over the years, GFAP has been shown to be involved in astrocyte functions, which are important during regeneration, synaptic plasticity and reactive gliosis. Moreover, different subpopulations of astrocytes have been identified, which are likely to have distinc...
To aid in the study of lower hybrid current drive as a means of current profile control, the radial profile and velocity distribution of the fast current-carrying electrons and their time evolution must be known. As part of the recent effort to understand this fast electron transport, a diagnostic has been installed on PBX-M to measure the electron cyclotron emission from the fast electrons. An oblique horizontal view of upshifted cyclotron emission in the midplane can give radial as well as velocity space information about the fast electrons. Emission in X mode frequencies refracted by the right-hand cutoff is radially localized. The observed emission at a specific frequency comes only from the radial region r_t_u_r_n=#0. Emission measured by this new diagnostic has been found to be radially localized as predicted. It is also expected that localized moments of the distribution ...
This report is devoted to the investigation of the influence of electron collisions and radial non-uniformity of plasma density on phase characteristics, spatial attenuation and wave field structure of slow symmetric electromagnetic waves that propagate along cylindrical waveguide structure. It has been shown that collision rate and radial non-uniformity of plasma density for various parameters of waveguide structure and dielectric affect essentially on the wave characteristics and consequently, on the parameters of gas discharge that is sustained by this wave. The results obtained are of large importance for the construction of the theory of gas discharges that are sustained by the surface electromagnetic waves.
The double-mode cepheid Y Car has been found to have a variable centre-of-mass velocity. Though the observations did not cover a cycle, an orbital period of about 400-600 days was estimated. Radial-velocity observations of this star have now been continued in order to derive the orbital elements. Observations were made with the photoelectric radial-velocity spectrophotometer at the coude focus of the 1.88-m reflector at Sutherland. The velocity system was standardized by frequent nightly observations of stars in the Mount Wilson catalogue with 'a'-quality radial velocities.
Role of ballooning effect in toroidal plasmas on the transient transport problems is investigated. Due to the mode localization along the magnetic field line, a meso scale appears in a radial correlation length of fluctuating fields. This scale length introduces the interference of the gradient and flux in different radial locations. For the fluctuation which gives the gyro-Bohm-like diffusion in a stationary state, this long radial correlation of the fluctuating field causes a fast propagation of response against a rapid transient perturbation. Upper bound of transient thermal diffusivity is derived. (author)
This paper attempts to explain the peculiarities of the radial-distribution function of metal glasses without involving ideas of the amorphous structure. On a computer, the radial atomic density for a spherical eutectic single crystal of the composition Fe/sub 84/C/sub 16/ of radius 15 A formed by alternating small crystals of e-Fe and Fe/sub 3/C of cubic form with the edge of the cube ca 10 A. For the sake of clarity, the diagram of such a quasisingle crystal is shown and has been given a cubic boundary. The change in the relationship between the heights of the subpeaks of the second maximum of the radial distribution function of atoms in the Fe-B glasses with a change in the concentration of boron can be explained by the change in the space group of the Fe/sub 3/B metastable boride which is formed in this system.
This paper introduces a novel three-phase power flow approach for unbalanced radial distribution systems. The proposed approach is developed based on the loop frame of reference, rather than the traditional bus frame of reference. On the basis of the loop frame of reference, a simple direct iterative method in impedance form is applied. Basic graph theory and injection current technique are also applied in the proposed approach. The clear theoretical foundation and the simple topology of the radial distribution network make the proposed method efficient and reliable. To demonstrate the better convergence performance and the efficiency of the proposed approach, four three-phase IEEE test feeders are used for comparisons. The test results show that the proposed method has robust convergence characteristics and high performance, especially for large-scale radial distribution systems. (author)
Molecular dynamics simulations have been carried out of the radial distribution function of the hard sphere fluid for a range of densities in the equilibrium fluid and just into the metastable region. The first derivative of the hard-sphere radial distribution function at contact was computed and its density dependence fitted to a simple analytic form. Comparisons were made with semi-empirical formulae from the literature, and of these the formula proposed by Tao et al (1992 Phys. Rev. A 46 8007) was found to be in best agreement with the simulation data, although it slightly underestimates the derivative at the higher packing fractions in excess of about 0.45. Close to contact, within a few per cent of the particle diameter, the radial distribution function can be represented well by a second order polynomial. An exponential function, which has some useful analytic features, can also be applied in this region.
The present emphasis on inherent safety for LMR designs has resulted in a need to represent the various reactivity feedback mechanisms as accurately as possible. The dominant negative reactivity feedback has been found to result from radial expansion of the core for most postulated ATWS events. For this reason, a more detailed model for calculating the reactivity feedback from radial core expansion has been recently developed for use with the SASSYS/SAS4A Code System. The purpose of this summary is to present an extension to the model so that it is more suitable for handling a core restraint design as used in FFTF, and to compare the SASSYS/SAS4A results using this model to the empirical correlation presently being used to account for radial core expansion reactivity feedback to FFTF.
A new semi-empirical algorithm for the radial distribution of dose is compared with available data. The algorithm is used to calculate the inactivation cross section for dry enzymes and viruses using an extended target model of a 1-hit detector. Agreement with data is at about the 15% level, approximating the precision of the data itself. (author).
The fission gas xenon bonded in bubbles, in pore, and in the lattice of mixed carbide fuels is measured by electron-probe microanalysis. Radial xenon distribution and release curves are determined and are calibrated by gas chromatography of the bonded fission gas and by burnup analysis in the respective pin sections of the irradiation experiments FR2 6A and 6C, Mol 11/K 2, and DFR 330/1. The results are correlated to the microstructure of the fuel, bonding medium, temperature, and burnup. (Auth.).
Radial distribution functions of liquid sodium and caesium at 100"0C have been calculated by the method of molecular dynamics with interionic pair potentials derived from Heine-Abarenkov-Shaw type model potential. The results were found to be in good agreement with recent experimental data. (Auth.).
Substantial changes in the radial distribution function of amorphous Si films have been observed in neutron-diffraction studies. The spectra indicate changes in short-range order associated with an approx.11% modification in the bond-angle distribution width. The results allow the first direct comparison of structural and vibrational Raman probes of variations in local order in thin-film amorphous solids. Good agreement is obtained between the measured bond-angle variation and that based on Raman estimates.
The radial distribution function and the second virial coefficient of interacting bosons have been studied. The second virial coefficient has been deduced theoretically and is in good agreement with experimental values. The third virial coefficient has been calculated from the experimental values of the pressure. (Auth.).
In this paper, a new design methodology for determining the size, location, type and number of capacitors to be placed on a radial distribution system is presented. The objective is to minimize the peak power losses and the energy losses in the distribution system considering the capacitor cost. A sensitivity analysis based method is used to select the candidate locations for the capacitors. A new optimization method using a Genetic Algorithm is proposed to determine the optimal selection of capacitors. Test results have been presented along with the discussion of the algorithm.
A formula for calculating the Dirac S-matrix for central Lorentz scalar and vector potentials is derived by use of a new amplitude-phase method. The derivation also makes use of certain invariants of the reduced 2-spinor radial Dirac equations.
A formula for calculating the Dirac S-matrix for central Lorentz scalar and vector potentials is derived by use of a new amplitude-phase method. The derivation also makes use of certain invariants of the reduced 2-spinor radial Dirac equations.
Suspension direct current plasma spraying allows achieving finely structured coatings whose thickness is between few tens and few hundreds of micrometres. Drops (200-300 ?m in diameter) or liquid jets are mechanically injected in the plasma jet. With radial injection they are rapidly (a few ?s) fragmented into droplets (a few ?m in diameter). The latter are vaporized (in a few ?s) and the solid particles contained in suspension droplets are accelerated and melted by the plasma jet. As in conventional plasma spraying (CPS), much smaller splats (with diameters between 0.2 and 3 ?m and thicknesses between 30 and 200 nm) are arranged in layers up to form the coating. The low inertia of particles requires spray distances between 40 and 60 mm which induces plasma heat fluxes up to 22 MW m-2 participating in coating densification. Even more than in CPS, the plasma jet fluctuations, particularly for plasmas containing di-atomic gases, perturb drops penetration and ...
An axisymmetric plasma screw pinch is an axisymmetric column of ionized gaseous plasma radially confined by forces from axial and azimuthal currents driven in the plasma and its surroundings. This dissertation is a contribution to detailed, high resolution computer simulation of dynamic plasma screw pinches in 2-d {ital rz}-coordinates. The simulation algorithm combines electron fluid and particle-in-cell (PIC) ion models to represent the plasma in a hybrid fashion. The plasma is assumed to be quasineutral; along with the Darwin approximation to the Maxwell equations, this implies application of Ampere`s law without displacement current. Electron inertia is assumed negligible so that advective terms in the electron momentum equation are ignored. Electrons and ions have separate scalar temperatures, and a scalar plasma electrical resistivity is assumed. Altemating-direction-implicit (ADI) methods are used to advance the electron fluid drift ...
A unique beam of pulsed electrons has been developed using the 19-MeV, 700-kA Hermes-III accelerator. The extended planar-anode diode is used to extract at large radius an annular electron beam from the accelerator and inject the resulting beam at small angle into a low-pressure gas cell, where the beam is rapidly charge neutralized and almost current neutralized. Under these conditions, the beam propagates nearly ballistically to a focus downstream of injection, where objects can be placed for irradiation and study. For a focal length of 78 cm, measurements with a segmented calorimeter show that this configuration can deliver an energy deposition of 200 J/g [20 Mrad] over a useful area of 70 cm{sup 2} and a 4-cm depth in graphite in 25 ns. Increasing the injection angle by reducing the AK gap permits higher doses over smaller areas to be achieved. Such beams are of interest for the study of material property changes from short-pulse high-energy depositions and for ...
The DNA double-strand break (DSB) damage response induced by high energy charged particles on lung fibroblast cells embedded in a 3-dimensional (3-D) collagen tissue equivalents was investigated using antibodies to the DNA damage response proteins gamma-histone 2AX (#gamma#-H2AX) and phosphorylated DNA-PKcs (p-DNA-PKcs). 3-D tissue equivalents were irradiated in positions across the linear distribution of the Bragg curve profiles of 307.7 MeV/nucleon, 556.9 MeV/nucleon, or 967.0 MeV/nucleon "5"6Fe ions at a dose of 0.30 Gy. Patterns of discrete DNA damage streaks across nuclei or saturated nuclear damage were observed, with saturated nuclear damage being more predominant as samples were positioned closer to the physical Bragg peak. Quantification of the DNA damage signal intensities at each distance for each of the examined energies revealed a biological Bragg curve profile with a pattern of DNA damage intensity similar to the physical Bragg curve for the ...
Propagation of an intense charged particle beam pulse through a background plasma is a common problem in astrophysics and plasma applications. The plasma can effectively neutralize the charge and current of the beam pulse, and thus provides a convenient medium for beam transport. The application of a small solenoidal magnetic field can drastically change the self-magnetic and self- electric fields of the beam pulse, thus allowing effective control of the beam transport through the background plasma. An analytic model is developed to describe the self-magnetic field of a finite- length ion beam pulse propagating in a cold background plasma in a solenoidal magnetic field. The analytic studies show that the solenoidal magnetic field starts to infuence the self-electric and self-magnetic fields when ?ce > ?pe?b, where ?ce = e?/mec is the electron gyrofrequency, ?pe is the electron plasma frequency, and ?b = Vb/c is the ion beam velocity relative to the speed of light. This condition ...
Astrocyte dysfunction is implicated in course of various age-related neurodegenerative diseases. Chronic injection of D-galactose can cause a progressive deterioration in learning and memory capacity and serve as an animal model of aging. To investigate the involvement of astrocytes in this model, oxidative stress biomarkers, biochemical and pathological changes of astrocytes were examined in the hippocampus of the rats with six weeks of D-galactose injection. D-galactose-injected rats displayed impaired antioxidant systems, an increase in nitric oxide levels, and a decrease in reduced glutathione levels. Consistently, western blotting and immunostaining of glial fibrillary acidic protein showed extensive activation of astrocytes. Double-immunofluorescent staining further showed activated astrocytes highly expressed inducible nitric oxide synthase. Electron microscopy demonstrated the degeneration of astrocytes, especially in the aggregated area of synapse and ...
We demonstrate a novel cross-sectional deformation, called the radial corrugation, of multi-walled carbon nanotubes (MWNTs) under hydrostatic pressure. Theoretical analyses based on the continuum elastic approximation have revealed that MWNTs consisting of more than ten concentric walls undergo elastic deformations at critical pressure Formula Not Shown , above which the circular shape of the cross-section becomes radially corrugated. Various corrugation modes have been observed by tuning the innermost tube diameter and the number of constituent walls, which is a direct consequence of the core-shell structure of MWNTs. Cross-sectional views of MWNT under high hydrostatic pressure: elliptic deformation with the mode index n = 2 (left), and radial corrugations with n = 5 (center), and n = 6 ...
The possibility of controlling the radial electric field of toroidal plasmas by injecting high energy electrons along the reversible loss cone orbit of the helical magnetic traps is investigated. It is well known that the radial electric field plays an important role in the confinement improvement scenario especially in the low collisional regime under the physics picture of neoclassical theory. For this purpose, it is made clear that the most suitable particles are transit particles, which show a transition from helically trapped orbits to blocked ones. It is also found that a parallel AC electric field launched from outside assists this transition and makes it possible for particles to penetrate deeply into the plasma. In addition we clarify that the viscosity of the plasma coupled with the helical field configuration provide a bifurcation of plasma states and its stable solution results in confinement improvement. (author)
The present paper describes the application of the commercial CFD-code FLUENT 6.1 to the numerical simulation of the flow field in a high specific speed radial fan. Two-dimensional as well as three-dimensional computations are performed using the steady 'Frozen-Rotor method' as well as the unsteady 'Sliding-Mesh method'. The predicted performance curves of the radial fan are compared with the results obtained from measurements on a test stand. Due to the relatively low computation times, the 'Frozen-Rotor method' can be used routinely for design purposes. The results of this approach can be improved if the leakage flow through the gap between the inlet nozzle and the impeller is taken into account. (orig.)
Dark matter particles form halos that contribute the major part of the mass of galaxy clusters. The formation of these cosmological structures have been investigated both observationally and in numerical simulations, which have confirmed the existence of a universal mass profile. However, the dynamic behaviour of dark matter in halos is not as well understood. We have used observations of 16 equilibrated galaxy clusters to show that the random velocities of dark matter particles are larger on average along the radial direction than along the tangential, and that the magnitude of this velocity anisotropy is radially varying. Our measurement implies that the collective behaviour of dark matter particles is fundamentally different from that of normal particles and the radial variation of the anisotropy velocity agrees with the predictions of numerical simulation.
New non-stationary non-contracted form of the erosive radially-slotted discharge as a thin round sheet with the current of the azimuth direction have been discovered, its existence beings stipulated by a radial transport-wave fluxes. Characteristic features of this discharge is self-confinement of the discharge current magnitude, corresponding decrease of the current pulse duration and occurrence of an energy and substance ejection with rather unusual properties. Measurements of kinetics of the discharge current, the plasma radiation intensity and an electrical probe signal, as well as the transmission electron microscope investigations of characteristic aerodisperse aggregates arising the erosive phase, have been carried out. The probe signal duration was about 10 times greater than that of the current; its kinetics was complicated suggesting existence in the slot of two components with fundamentally different properties and states of the ...
The separator can be used for electrical separation of the drilling string used as the channel of communication with transmission of face information. It contains upper and lower metal conductors electrically insulated from each other by an insulator made of layered polymer composite material. In order to improve reliability of the connection of the conductors to the insulator and reduce the metal consumption on the ends of the conductors that come into contact with the insulator there are graduated niches with radial projections. The latter form jointly with the layers of the insulator a crown-radial-multiple stage undetachable connection. The niches decreases from the outer diameter of the conductors to the inner. The insulator has additional layers made of high-module fibers of carbon or boron which cover the radial projections in stages.
Radial sonic crystals (RSC) are fluidlike structures infinitely periodic along the radial direction that verify the Bloch theorem and are possible only if certain specially designed acoustic metamaterials with mass density anisotropy can be engineered (see Torrent and Sanchez-Dehesa 2009 Phys. Rev. Lett. 103 064301). A comprehensive analysis of two-dimensional (2D) RSC shells is reported here. A given shell is in fact a circular slab with a central cavity. These finite crystal structures contain Fabry-Perot-like resonances and modes strongly localized at the central cavity. Semi-analytical expressions are developed to obtain the quality factors of the different resonances, their symmetry features and their excitation properties. The results reported here are completely general and can be extended to equivalent 3D spherical shells and to their photonic counterparts.
The energy deposited by the passage of a single, energetic, heavy-ion through a semiconductor produces dense electron-hole (eh) pair concentrations near the ion trajectory. The size, shape, and charge density of an ion track represent critical parameters for many models of single event phenomena. The authors describe the design and uses of possible semiconductor test structures for measuring the initial radial distribution of charge and subsequent charge transport in a high energy, heavy-ion track. Numerical simulations show how the test structure can resolve different radial distributions of charge within an ion track. The test structure simulations also show the importance of accurately representing ion track structure in single event effects simulations.
Thin film solar cells and solar cell testing - photovoltaic cells, radiation damage to cadmium sulfide solar cells, and airplane testing of solar cells
Abstract The term -stem cell- most commonly refers to embryonic stem cells, particularly in the lay media; however, it also describes other cell types. A stem cell represents a cell of multi-lineage potential with the ability for self-renewal. It is now clear that the plasticity and immortality of a given stem cell will depend on what type of stem cell it is, whether an embryonic stem cell, a fetal-placental stem cell or an adult stem cell. Stem cells offer great promise as cell-based therapies for the future. With evolving technology, much of the socio-political debate regarding stem cells can now be avoided.
We obtain the radial Dirac equations for the Plebanski metric and transform these equations into one-dimensional wave equations. Finally we conclude with the result that the electron and the neutrino fields are not superradiant.
The present emphasis on inherent safety for liquid-metal reactor designs has resulted in a need to represent the various reactivity feedback mechanisms as accurately as possible. The dominant negative reactivity feedback has been found to result from radial expansion of the core for most postulated anticipated transient without scram events. For this reasons, a more detailed model for calculating the reactivity feedback from radial core expansion, including subassembly bowing has been recently developed for use with the SASSYS/SAS4A code system. The purpose of this summary is to present an extension to the model so that it is more suitable for handling a core restraint design as used in the Fast Flux Test Facility (FFTF), and to compare the SASSYS/SAS4A results using this model to the empirical correlation presently being used to account for radial core expansion reactivity feedback in the FFTF.
Extensive investigations and detailed analysis of the failure reason of 9DVN002ZV fan in Daya Bay Nuclear Power Station showed that the fan destroy was caused by the failure of non-drive end bear. The direct cause of this bearing' failure was its improper assembly caused by improper maintenance procedure, and the root cause was too small internal radial clearance after mounting. The factor affecting bearing internal radial clearance, the relationship between clearance and operating life time and fan failure process were discussed. (authors)
The title invention aims at a vibrations-free running of the flywheel to realize a high speed (18,000-20,000 revolutions per minute). The flywheel consists of a case which holds a central stator, a rotor and two ball-bearings. The ball-bearings have a first radial stiffness and are placed in between the rotor and an upper, respectively lower support bearer. The support bearers are supported on the stator with a second radial stiffness. The top and the bottom of the stator is connected to the case by means of a support with a third stiffness. 6 figs.
A clear and reproducible transition to a regime with an improved particle confinement is routinely observed on the CASTOR tokamak, if the biasing electrode is inserted deep enough into the plasma (r/a?0.5) and biased up to +250 V. The steepening of the radial profiles of the plasma density and potential demonstrate the formation of a transport barrier just inside the last closed flux surface. Fast relaxations of the edge plasma parameters, with a frequency of about 10 kHz, are observed when the average radial electric field within the barrier prevails values of about 20 kV/m. A detailed analysis of the spatial-temporal behaviour of these relaxations is presented.
XAFS data of metallic glass Al_0_._9_1La_0_._0_9 and a crystalline phase Al_1_1La_3 formed by annealing of the glass were measured at the La L_3 edge at T=12 K and analyzed using the radial distribution function method. The shortest La-Al distance appeared to be distinctively smaller within the glass than in the crystal. This difference decreases the disparity in size of La and Al in the alloy, allowing their mixing in the glassy state. ((orig.)).
Longitudinal space charge (LSC) force can be a main effect driving the microbunching instability in the linac for an x-ray free-electron laser (FEL). In this paper, the LSC-induced beam modulation is studied using an integral equation approach that takes into account the transverse (radial) variation of LSC field for both the coasting beam limit and bunched beam. Changes of beam energy and the transverse beam size can be also incorporated. We discuss the validity of this approach and compare it with other analyses as well as numerical simulations.
A sample of 41 radio-galaxies with 13.0<=msub(corr)<=15.5 has been analyzed to test the angular redshift anisotropy discovered on Sc I galaxies by Rubin, Rubin and Ford (1973). The sample does not present their anisotropy but contains an even more curious distribution of radial velocities which suggests that the Rubin-Ford effect results from an anomalous redshift of light when it travels through clusters of galaxies. (Auth.).
The outward radial expansion of a free liquid annulus is a common problem of both earlier and current ICF blanket design. Whether the annulus fractures or not depends on the internal pressure and surface stability. In this paper a model based on incompressible cylindrically symmetric flow is used to get a theoretical solution similar to that of the Rayleigh's solution for bubble dynamics. The pressure inside the annulus is found positive all time but the peak is lowering during the expansion. Besides, both surfaces are Taylor stable during such motion. Thus, it is concluded that an annulus in outward radial motion will not cavitate or breakup.
Differential cross sections have been measured for the elastic and inelastic scattering of 104 MeV alpha-particles from /sup 90/,/sup 92/Zr. The experimental data are analyzed in terms of coupled channels on the basis of a flexible anharmonic vibrator model and using different parametrizations of the radial shape of the extended optical potential. The results favour the squared Saxon-Woods type for the real part. Additionally to a radial momentum analysis of the real potentials a semimicroscopic folding model has been invoked for extracting isoscalar quadrupole and hexadecapole transition rates.
Differential cross sections have been measured for the elastic and inelastic scattering of 104 MeV alpha-particles from "9"0,"9"2Zr. The experimental data are analyzed in terms of coupled channels on the basis of a flexible anharmonic vibrator model and using different parametrizations of the radial shape of the extended optical potential. The results favour the squared Saxon-Woods type for the real part. Additionally to a radial momentum analysis of the real potentials a semimicroscopic folding model has been invoked for extracting isoscalar quadrupole and hexadecapole transition rates. (orig.).
Human bone marrow mesenchymal stem cells (BM-MSC) are multipotent progenitor cells that have transient immunomodulatory properties on Natural Killer (NK) cells, Dendritic Cells (DC), and T cells. This...Full Text Available
Motivation: Automatic recognition of cell identities is critical for quantitative measurement, targeting and manipulation of cells of model animals at single-cell resolution. It has been...Full Text Available
We study the spin dependence of accretion onto rotating Kerr black holes using analytic techniques. In its linear regime, angular momentum transport in MHD turbulent accretion flow involves the generation of radial magnetic field connecting plasma in a differentially rotating flow. We take a first principles approach, highlighting the constraint that limits the generation and amplification of radial magnetic fields, stemming from the transfer of energy from mechanical to magnetic form. Because the energy transferred in magnetic form is ultimately constrained by gravitational potential energy or Killing energy, the spin dependence of the latter allows us to derive spin-dependent constraints on the success of the accreting plasma to expel its angular momentum. We find an inverse relationship between this ability and black hole spin. If this radial magnetic field generation forms the basis for angular momentum transfer in ...
We present high-precision time-series photometry of the classical delta Scuti star HD 144277 obtained with the MOST (Microvariability and Oscillations of STars) satellite in two consecutive years. The observed regular frequency patterns are investigated asteroseismologically. HD 144277 is a hot A-type star that is located on the blue border of the classical instability strip. While we mostly observe low radial order modes in classical delta Scuti stars, HD 144277 presents a different case. Its high observed frequencies, i.e., between 59.9c/d (693.9 microHz) and 71.1c/d (822.8microHz), suggest higher radial orders. We examine the progression of the regular frequency spacings from the low radial order to the asymptotic frequency region. Frequency analysis was performed using Period04 and SigSpec. The results from the MOST observing runs in 2009 and 2010 were compared to each other. The resulting frequencies were submitted to ...
The visual outcomes of Acanthamoeba keratitis, a rare cause of corneal infection, can be devastating. This paper reports two contact lens wearers with severe pain and photophobia who presented to the emergency room. Biomicroscopy revealed radial keratoneuritis in both individuals. Tissue culture on a nonnutrient agar plate with Escherichia coli overlay resulted in a heavy growth of Acanthamoeba. The inpatient treatment included 0.02% polyhexamethylene biguanide, chlorhexidine, neomycin/polymyxin B/bacitracin (Neosporin), and oral fluconazole, which successfully controlled the corneal infection and improvement in the best corrected visual acuity in both patients. Infection did not recur during the 12-month follow-up period. Acanthamoeba keratitis can present as radial keratoneuritis, mimicking other common corneal infections resulting in diagnostic and treatment delays. Early diagnosis and prudent treatment of Acanthamoeba keratitis are the keys ...
We present analytic and numerical results which illustrate the effects of Jupiter's accretion of nebular gas and the planet's radial migration on its Trojan companions. Initially, we approximate the system by the planar circular restricted three-body problem and assume small Trojan libration amplitudes. Employing an adiabatic invariant calculation, we show that Jupiter's thirty-fold growth from a $10 M_\\oplus$ core to its present mass causes the libration amplitudes of Trojan asteroids to shrink by a factor of about 2.5 to $\\sim 40%$ of their original size. The calculation also shows that Jupiter's radial migration has comparatively little effect on the Trojans; inward migration from 6.2 to 5.2 AU causes an increase in Trojan libration amplitudes of $\\sim4%$. In each case, the area enclosed by small tadpole orbits, if made dimensionless by using Jupiter's semimajor axis, is approximately conserved. Similar adiabatic invariant calculations ...
In the frame of the European Technology R and D programme for International thermonuclear experimental reactor (ITER) and in the area of high heat flux plasma facing components (HHFC), representative small-scale mock-ups were manufactured and tested to compare different concepts and joining technologies (i.e. active brazing, hot isostatic pressing (HIPping), diffusion bonding, etc.). On the basis of the results obtained by thermal fatigue tests, the monoblock concept resulted to be the most robust one, particularly when the HIPping manufacturing technology is used. Within this programme, ENEA developed an alternative technique for manufacturing plasma-facing components with a monoblock geometry of the ITER machine. The basic idea of this technique, named hot radial pressing (HRP), is to perform a radial diffusion bonding between the cooling tube and the armour tile by pressurising the internal tube only and by keeping the process parameters ...
The thermal contact resistance between balls and inner and outer rings of thermally steady space-use deep groove ball bearings was studied experimentally to verify the validity of the previously proposed calculation method for the resistance. The 440C stainless steel single row bearing was used for measuring its steady state temperature distributions in a vacuum environment under axial, radial and combined load conditions. As a result, the experimental results of the resistance well agreed with calculated ones under each load condition resulting in the sufficient validity at nearly the same surface roughness. It was necessary to apply a static equivalent radial load to calculation under the combined load that a contact angle is larger than the angle of resultant force dependent on both load components. In experiments under only radial load, measurement of outer ring temperatures was necessary at some points with no contact ...
In this work, the Calibration-Free approach for Laser-Induced Breakdown Spectroscopy (CF-LIBS) was applied for the first time to radially resolved spectra emitted by a laser-induced plasma. The radial profiles of plasma temperature and electron number density were used to calculate the local relative concentration of the elements of interest. We analyzed a set of profiles of the local spectral emission coefficient obtained previously by means of spatial deconvolution of the spectra from a copper-based alloy (Cu 93, Fe 5, Mn 1, Ni 1 wt.%) laser-induced plasma. A spatially integrated spectrum of the same plasma was also analyzed for comparison purpose. The relative abundance of the minor components Fe, Mn and Ni was calculated. The results obtained from the central region of the plasma were closer to the nominal concentrations than those obtained from the spatially integrated spectrum. However, an increasing deviation was observed towards the ...
In this work, the Calibration-Free approach for Laser-Induced Breakdown Spectroscopy (CF-LIBS) was applied for the first time to radially resolved spectra emitted by a laser-induced plasma. The radial profiles of plasma temperature and electron number density were used to calculate the local relative concentration of the elements of interest. We analyzed a set of profiles of the local spectral emission coefficient obtained previously by means of spatial deconvolution of the spectra from a copper-based alloy (Cu 93, Fe 5, Mn 1, Ni 1 wt.%) laser-induced plasma. A spatially integrated spectrum of the same plasma was also analyzed for comparison purpose. The relative abundance of the minor components Fe, Mn and Ni was calculated. The results obtained from the central region of the plasma were closer to the nominal concentrations than those obtained from the spatially integrated spectrum. However, an increasing deviation was observed towards the ...
We studied telomeric DNA in leukemic cells as well as in normal T cells, B cells, monocytes, polymorphonuclear leukocytes, and bone marrow hematopoietic progenitor cells. No marked differences were...Full Text Available
We present ultraviolet through far-infrared (FIR) surface brightness profiles for the 75 galaxies in the Spitzer Infrared Nearby Galaxies Survey (SINGS). The imagery used to measure the profiles includes Galaxy Evolution Explorer UV data, optical images from Kitt Peak National Observatory, Cerro Tololo Inter-American Observatory, and Sloan Digital Sky Survey, near-IR data from Two Micron All Sky Survey, and mid- and FIR images from Spitzer. Along with the radial profiles, we also provide multi-wavelength asymptotic magnitudes and several nonparametric indicators of galaxy morphology: the concentration index (C 42), the asymmetry (A), the Gini coefficient (G), and the normalized second-order moment of the brightest 20% of the galaxy's flux (M-bar20). In this paper, the first of a series, we describe the technical aspects regarding the surface photometry, and present a basic analysis of the global and structural properties of the SINGS galaxies at different ...
Abstract In this paper, the effect of several turbulence parameters during various flow conditions in Owens Valley, educed from coherent Doppler lidar data have been studied. Radial velocity structure functions are processed to estimate the turbulent kinetic energy (TKE) dissipation rate, integral length scale and velocity variance, assuming a theoretical model for isotropic wind fields. Corrections for turbulence measurements have been considered to address the complications due to inherent volumetric averaging of radial velocity over each range gate, noise of the lidar data, and the assumptions required to estimate effects of smaller scales of motion on turbulence quantities. Using data from the Terrain-induced Rotor Experiment (T-REX) in April-May 2006, vertical profiles of wind and tur...
Determining the radial distribution of the thermal neutron field in the core of the Dalat reactor was done by the Cu foil activation method. The measured data were fitted by the least square method to determine some physical parameters of the reactor, as follows: 1. Laplacian: B_r"2 = (84.6 +- 5.5)10_-_4/,cm"2. 2. The effective radius: R_e_f_f = (27.6 +- 1.0)cm. 3. The extrapolation distance: #lambda#_r = (8.7 +- 1.0)cm. 4. The unequal coefficient of the effective multiplication: k_r = 1.77 +- 0.11. (author). 3 refs., 4 figs., 1 tab.
A rotary drill bit having a drill bit body and at least one trunnion projecting from the drill bit body and a rotary cutter supported on at least one radial roller bearing on the trunnion. The rolling elements of the bearing are guided on at least one axial end facing the drill bit body in an outer bearing race groove incorporated in the bore of the rotary cutter. The inner bearing race groove is formed on the trunnion for the rolling elements of the radial roller bearing. At least one filling opening is provided which extends through the drill bit body and trunnion and is essentially axially oriented having one terminal end adjacent the inner bearing race groove and at least one filler piece for sealing the opening.
The noncrystalline compounds MoS_3, WS_3 and MoSe_3 were studied by X-ray diffraction. From the diffuse intensities radial distribution functions were computed and interpreted in terms of pair distribution functions. The substances are built up by microcrystallites which contain three metal atoms and are bridged statistically to each another. The shortest metal chalcogen distances d(MoS) approximately d(WS) = 2.40 +- 0.05 A and d(MoSe) = 2.50 +- 0.05 A are significantly longer than in MS- or MSe compounds with a d"0 configuration of the metal respectively and metal-metal distances within the microcrystallites are less than 3 A. (author).
A generalized relativistic harmonic oscillator for spin 1/2 particles is studied. The Dirac Hamiltonian contains a scalar, $S$, and a vector, $V$, quadratic potentials in the radial coordinate, as well as a tensor potential, $U$, linear in $r$. Setting either or both combinations $\\Sigma=S+V$ and $% \\Delta=V-S$ to zero, analytical solutions for bound states of the corresponding Dirac equations are found. The eigenenergies and wave functions are presented and particular cases are discussed, devoting a special attention to the non-relativistic limit and the case $\\Sigma=0$, for which pseudospin symmetry is exact. We also show that the case $U=\\Delta=0$ is the most natural generalization of the non-relativistic harmonic oscillator. The radial node structure of the Dirac spinor is studied for several combinations of harmonic oscillator potentials, and that study allows us to explain why nuclear intruder levels cannot be described in the ...
The authors describe a new method which makes it possible to determine the radial distribution of the diffuse component of galactic gamma rays outside the solar circle. They use the observation that a good correlation exists between gamma-ray intensities and total column densities of the local interstellar gas and that the fractional column density of H_2<0.1 HI outside the solar circle. Thus the gamma-ray intensities are shown to be proportional to N(HI). The authors use the kinematics of the HI to determine the distances from which various fractions of the emission originate in the second and third galactic quadrants. Preliminary results of our analysis show that a significant flux of gamma rays originates from distances as large as 18 kpc from the galactic centre. (Auth.).
The confining effect of a spherical substrate inducing anchoring (normal to the surface) of rod-like liquid crystal molecules contained in a thin film spread over it has been investigated with regard to possible changes in the nature of the isotropic-to-nematic phase transition as the sample is cooled. The focus of these Monte Carlo simulations is to study the competing effects of the homeotropic anchoring due to the surface inducing orientational ordering in the radial direction and the inherent uniaxial order promoted by the intermolecular interactions. By adopting entropic sampling procedure, we could investigate this transition with a high temperature precision, and we studied the effect of the surface anchoring strength on the phase diagram for a specifically chosen geometry. We find that there is a threshold anchoring strength of the surface below which uniaxial nematic phase results, and above which the isotropic fluid cools to a ...
We have investigated the properties of nerve cell precursors in hydra by analyzing the differentiation and proliferation capacity of interstitial cells in the peduncle of Hydra oligactis, which is a region of active nerve cell differentiation. Our results indicate that about 50% of the interstitial cells in the peduncle can grow rapidly and also give rise to nematocyte precursors when transplanted into a gastric environment. If these cells were committed nerve cell precursors, one would not expect them to differentiate into nematocytes nor to proliferate apparently without limit. Therefore we conclude that cycling interstitial cells in peduncles are not intermediates in the nerve cell differentiation pathway but are stem cells. The remaining interstitial cells in the peduncle are ...
A silicon solar cell assembly comprising a large, thin silicon solar cell bonded to a metal mount for use when there exists a mismatch in the thermal expansivities of the device and the mount.
Experiments were designed to elucidate whether or not the irradiated bone marrow cells receive any stimulation for the self-replication and differentiation from normal 'stromal' cell colonies in the bone marrow cell culture in vitro. When irradiated or unirradiated bone marrow cells were overlaid on the normal adherent cell colonies, the proliferation of haemopoietic stem cells was supported, the degree of the stimulation depending on the starting cellular concentration. There was, however, no significant changes in the concentration of either CFUs or CFUc regardless of the dose of irradiation on the bone marrow cells overlaid. This was a great contrast to the dose-dependent decrease of CFUs or CFUc within the culture in which both the stem cells and stromal cells were ...
Ethane oxidation was studied in ethane-grown resting cells (mycelia) of an Acremonium sp. and in cell-free preparations of such mycelia. From resting cell experiments evidence was found for a pathway...Full Text Available
In most adult tissues there reside pools of stem and progenitor cells inside specialized microenvironments referred to as niches. The niche protects the stem cells from inappropriate expansion...Full Text Available
... Fuel Cell Technologies Equipment on Environmental Expert Find and compare a variety of fuel cell technologies equipment on the world's largest environmental industry portal. View ...
Purpose.There is a paucity of neuron replacement studies for retinal ganglion cells. Given the complex phenotype of these neurons, replacement of ganglion cells may be impossible....Full Text Available
Cell cultures were prepared from lung tumors occurring in beagles following exposure to inhaled plutonium. Morphologic and growth characteristics of two of these cell lines are described.
We report the isolation of adherent, clonogenic, fibroblast-like cells with osteogenic and adipogenic potential from the blood of four mammalian species. These cells phenotypically resemble but are...Full Text Available
The wind unit working wheel has 4 radial rectangular frames arranged in two vertical planes which are perpendicular to each other. In the planes limited by the frames, on loop hinges with limiting supports, there are flat blades. When the working wheel rotates under the influence of wind pressure, the blades automatically occupy a vertical or horizontal (wind vane) position depending on the direction of blade motion and the direction of wind velocity.
Transition rates for electrons in the superheavy elements Z = 114, 126, 134, 145, 164 and 173 are calculated. K, L and M-shells are considerd as final states. The 2s - 1s stransition of multipolarity M1 is dominant for Z = 173 with a transition time of 10"-"1"8s. The radial expectation values and #sq root# are given. (orig.).
The completed ribbon-winding theory, including temperature loading of the high-pressure compound vessel, was proposed. The influence of the bending stress in the wound ribbon is taken into account. Internal core of the compound vessel consists of matrix and ring, made of different materials. The relations were derived in analytical form, describing the radial distribution of necessary tangential prestressing.
The general relativistic version is developed for Robertson's discussion of the Poynting-Robertson effect that he based on special relativity and Newtonian gravity for point radiation sources like stars. The general relativistic model uses a test radiation field of photons in outward radial motion with zero angular momentum in the equatorial plane of the exterior Schwarzschild or Kerr spacetime.
In this Letter the bound states of (2+1) Dirac equation with the cylindrically symmetric $\\delta (r-r_{0})$-potential are discussed. It is surprisingly found that the relation between the radial functions at two sides of $r_{0}$ can be established by an SO(2) transformation. We obtain a transcendental equation for calculating the energy of the bound state from the matching condition in the configuration space. The condition for existence of bound states is determined by the Sturm-Liouville theorem.
The motion of a test particle moving in an interior static spherically symmetric geometry is investigated. The author concludes that an oscillatory motion with the test particle changing its motion from a free fall towards the center to an outward radial motion can not exist for any static interior spherically symmetric model.
The Klein-Gordan equation in the background of the Schwarzschild curved space-time is considered and the scattering of radial tardyons and tachyons from a black hole is studied. It is shown that black holes of mass below 7x10/sup 14/g may contain bound states of tardyons of pion mass which will be unstable on account of the presence of an attractive r/sup -4/ term.
The Klein-Gordan equation in the background of the Schwarzschild curved space-time is considered and the scattering of radial tardyons and tachyons from a black hole is studied. It is shown that black holes of mass below 7x10"1"4g may contain bound states of tardyons of pion mass which will be unstable on account of the presence of an attractive r"-"4 term. (author).
''Magnetic braking'' of the plasma toroidal rotation in the high confinement H mode by applied resonant, low m,n=1 static error fields is used in DIII-D [Nucl. Fusion 31, 875 (1991)] as an independent control to evaluate the E_rxB stabilization of microturbulence in the plasma core. In the core (#rho# approx-lt 0.9) of a tokamak, the radial electric field and its shear are dominated by toroidal rotation. The fundamental quantity for shear stabilization of microturbulence is shear in the velocity of the fluctuations v_p_e_r_p_e_n_d_i_c_u_l_a_r#approx#E_rxB/B#centre dot#B which in the core is v_p_e_r_p_e_n_d_i_c_u_l_a_r#approx#v_#phi#B_#theta#/ B_#phi#. With magnetic braking greatly decreasing the toroidal rotation and thus reducing the core radial electric field and shear, far infrared (FIR) measurements of density microturbulence show downshifting in frequency near #rho##approx#0.8 as a result of the reduced Doppler shift ...
Radiation therapy has shown definite technical improvement due to application of proton beam irradiation. Clinical results of proton beam therapy also suggested enlargement of indication ranges in radial treatment and decrease of post radiation damages of the treatment of cancers in deep-seated organs. Inprovement of result in cancer therapy could be expected by this treatment technique in the future.
A general theorem on the GBDT version of the B\\"acklund-Darboux transformation for systems rationally depending on the spectral parameter is treated and its applications to nonlinear equations are given. Explicit solutions of direct and inverse problems for Dirac-type systems, including systems with singularities, and for the system auxiliary to the $N$-wave equation are reviewed. New results on explicit construction of the wave functions for radial Dirac equation are obtained.
Considering the radial motion of a test particle in the Schwarzschild field in the hypothesis of local rotational invariance, the authors discuss the conditions to be satisfied by a physically acceptable model of broken SO(3,1) symmetry, and shown in particular that to preserve causality a breaking, even infinitesimal, makes necessarily impenetrable the interior of the Schwarzschild sphere.
Impact of apparatus dead time on the accuracy of measurement of radial distribution of the radiation attenuation factor in the roentgen computer tomography for rotation bodies is studied. Analytical expressions are obtained. Calculations of the threshold loads for radiometric detectors, providing for the accuracy of measurement at the stage of designing the tomographic complex detecting unit, are obtained
The influence of RTA (Rapid Thermal Anneal) treatment on MOS radiation hardness is demonstrated and compared with classical furnace treatment. In the case of the RTA, the oxide trapped charge is found to depend on: (i) the anneal temperature as expected, data are in good agreement with a recently developed model of oxygen out-diffusion; (ii) the location across the wafer with a radial dependence, results could be related to stress induced by thermal gradient.
Compton scatter tomography utilizes the electronic collimation characteristics available through the Compton scattering angle-energy correlation to obtain tomographic images. In this work we present particular aspects of the technique, which are relevant to the inverse radiation transport problem of reducing marginal projection data to radial two-phase flow regime maps. The results indicate a viable technique for the tomographic imaging of tow-phase flow using practical source strengths and reasonably few detectors.
A unified calculation of neutron-rich isotopes in lithium is performed using the hyperspherical basis in which the underlying symmetry of each isotope exhibits a simple structure. The variation of the binding energy as a function of mass number is qualitatively reproduced, and the asymptotic of radial distribution of each isotope decreases exponentially. The form factors of the lithium isotopes are calculated and display diffraction minima. 27 refs., 3 figs., 3 tabs.
Effects of cell concentrations on the survival and repopulation of haemopoietic stem cells after irradiation were studied in the long-term culture of mouse bone marrow cells in vitro. No difference was observed in the survival of the stem cells among cultures in which 0 - 10/sup 7/ cells were re-inoculated on the adherent cell colonies in the culture flask. Stem cells showed a significant proliferation within 1 week and the number of the stem cells exceeded the control in 3 weeks after irradiation in the cultures with less than 10/sup 6/ re-inoculated cells per flask. In contrast, there was a considerable delay in the onset of stem cell proliferation after irradiation in the culture with 10/sup 7/ cells per flask. Based on these results, a possibility that a ...
SummaryIn vivo tumor cell migration through integrin-dependent pathways is key to the metastatic behavior of malignant cells. Using quantitative in vivo...Full Text Available
Terminal differentiation of many vascular cells involves cell wall changes. Cells first elongate their primary wall, then lay down a lignified secondary wall, which is often followed by digestion of...Full Text Available
For proper tissue morphogenesis, cell divisions and cell fate decisions must be tightly and coordinately regulated. One elegant way to accomplish this is to couple them with asymmetric cell divisions....Full Text Available
Totipotent stem cells have the potential to differentiate into every cell type. Renewal of totipotent stem cells in the germline and cellular differentiation during early embryogenesis rely upon posttranscriptional...Full Text Available
We have established a cartilaginous fish cell line [Squalus acanthias embryo cell line (SAE)], a mesenchymal stem cell line derived from the embryo of an elasmobranch, the spiny dogfish...Full Text Available
AIM: To isolate and identify the biological characteristics of human colon cancer stem cells (SW1116 cells) and further study their proteome.METHODS: SW1116 cells were isolated and cultured with...Full Text Available
Interleukin 2 (IL-2) and B-cell growth factors I and II (BCGF I and BCGF II) are lymphokines produced by T cells that play a major role in T- and B-cell cooperation. Peripheral blood lymphocytes from...Full Text Available
Normal cells, both in vivo and in vitro, become quiescent after serial cell proliferation. During this process, cells can develop immortality with genomic instability,...Full Text Available
BackgroundStem cell characteristics are an important feature of human cancer cells and play a major role in the therapy resistance of tumours. Strategies to target cancer stem cells...Full Text Available
Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibroblasts) are known to communicate with one another. Their interactions not only serve to support fully functional blood...Full Text Available
BackgroundAs the resident stem cells of skeletal muscle, satellite cells are activated by extracellular cues associated with local damage. Once activated, satellite cells will re-enter...Full Text Available
Craniofacial injuries require a variety of different cell types to repopulate areas of bone, cartilage, tendon, and fat. Mesenchymal stem cells (MSCs) provide a multipotent cell source for tissue...Full Text Available
We describe the lethal, recessive accelerated-cell-death11 Arabidopsis mutant (acd11). Cell death in acd11 exhibits characteristics of animal apoptosis...Full Text Available
Somatic cell nuclear transfer or therapeutic cloning has provided great hope for stem cell-based therapies. However therapeutic cloning has been experiencing both ethical and technical difficulties....Full Text Available
Background:Stem cells can differentiate into multiple cell types, and therefore can be used for cellular therapies, including tissue repair. However, the participation of stem cells...Full Text Available
It has been postulated that thrombin binds to endothelial cells through, at least in part, cell surface glycosaminoglycans such as heparan sulfate, which could serve as antithrombin cofactor on the...Full Text Available
Hematopoietic stem cells replenish all the cells of the blood throughout the lifetime of an animal. Although thousands of stem cells reside in the bone marrow, only a few contribute to blood production...Full Text Available
In the growing chloronema cell suspension cultures of the moss Funaria hygrometrica Hedw., activities of several enzymes have been found to be cell-density-dependent. Cyclic nucleotide...Full Text Available
In preimplantation mouse development, the first cell lineages to be established are the trophectoderm (TE) and inner cell mass. TE possesses epithelial features, including apical-basal cell polarity...Full Text Available
...false Guidelines for Human Stem Cell Research Presidential Documents ...2009 Guidelines for Human Stem Cell Research Memorandum for the Heads...scientifically worthy human stem cell research, including human...
We have developed a cell-mediated mutagenesis assay in which cells with the appropriate markers for mutagenesis are co-cultivated with either lethally irradiated rodent embryonic cells that can metabolize carcinogenic hydrocarbons or with primary rat liver cells that can metabolize chemicals carcinogenic to the liver. During co-cultivation, the reactive metabolites of the procarcinogen appear to be transmitted to the mutable cells and induce mutations in them. Assays of this type make it possible to demonstrate a relationship between carcinogenic potency of the chemicals and their ability to induce mutations in mammalian cells. In addition, by simultaneously comparing the frequencies of transformation and mutation induced in normal diploid hamster cells by benzo(a)pyrene (BP) and one of its metabolites, it is possible to estimate the genetic ...
...Basic Information | Fuel Cells & Vehicles | US EPA This web page provides basic information on EPA's Fuel Cells & Vehicles web site ...including the chemical composition of fuel cell technology, how it works, descriptions of the various types of fuel cells , their availability and ... background,electrochemical,hydrogen,fuel cell,fuel cell vehicle,fuel reformer,performace,improved fuel economy,increased engine efficiency,lower emissions,zero emissions,availablity,fuel cell types,diagram,Proton ...Exchange Membrane,PEM Basic Information | Fuel Cells & Vehicles | US EPA background,electrochemical,hydrogen,fuel cell,fuel cell vehicle,fuel reformer,performace,improved fuel economy,...
Laser-assisted processing techniques for producing high-quality solar cell metallization patterns are investigated, developed, and characterized. The tasks comprising these investigations are outlined. A new batch of solar cells was processed using the laser decomposition of spun-on silver neodecanoate to metallize cells. Decomposition of silver neodecanoate was carried out at different laser powers on different cells on a given wafer to determine whether this would have any effect on cell performance. Solar cells which were written with laser powers of 5 to 8 watts, gave excellent results with cell efficiencies in the range of 14 to 16%.
... nent to the design and construction of metal-semiconductor solar cells, in that both the photovoltage and the efficiency of metal-semiconductor cells ...
... and pathogen transmission. Because the ultimate object of stem cell research is cell-based clinical therapy, hES cells should ... 4%) Supported by grants (SC12021 and SC11012) from Stem Cell Research...
Abstract Epstein-Barr virus (EBV), which infects not only B cells, but also T cells and natural killer (NK) cells, is associated with multiple lymphoid malignancies. Recently, the proteasome inhibitor bortezomib was reported to induce apoptosis of EBV-transformed B cells. We evaluated the killing effect of this proteasome inhibitor on EBV-associated T lymphoma cells and NK lymphoma cells. First, we found that bortezomib treatment decreased the viability of multiple T and NK cell lines. No significant difference was observed between EBV-positive and EBV-negative cell lines. The decreased viability in response to bortezomib treatment was abrogated by a pan-caspase inhibitor. The induction of apoptosis was confirmed by flow cytometric assessment of annexin V staining. Additionally, cleavage o...
In order to identify cells of maternal origin in CVS cultures, tissue from 1st trimester abortions were cultivated and the cultures stained in situ for X-chromatin. Convoluted cells and maternal fibroblasts were found to be positive. By chromosome analysis of cultures from 105 diagnostic placenta biopsies, obtained by the transabdominal route, metaphases of maternal origin were found in nine cases. In eight of these cases colonies of convoluted cells were observed. We conclude that convoluted cells are of maternal origin and are a reliable marker for maternal cell contamination in CVS cultures.
An assay system for the stem cell that colonizes the thymus and differentiates into T cells was developed, and by using this assay system the existence of two subpopulations of stem cells for T cell lineage was clarified. Part-body-shielded and 900-R-irradiated C57BL/6 (H-2b, Thy-1.2) recipient mice, which do not require the transfer of pluripotent stem cells for their survival, were transferred with cells from B10 X Thy-1.1 (H-2b, Thy-1.1) donor mice. The reconstitution of the recipient's thymus lymphocytes was accomplished by stem cells in the donor cells and those spared in the shielded portion of the recipient that competitively colonize the thymus. Thus, the stem cell activity of donor cells can be evaluated by determining the proportion of donor-type (Thy-1.1+) ...
Understanding prostate stem cells may provide insight into the origin of prostate cancer. Primary cells have been cultured from human prostate tissue but they usually survive only 15-20 population doublings before undergoing senescence. We report here that RC-170N/h/clone 7 cells, a clonal cell line from hTERT-immortalized primary non-malignant tissue-derived human prostate epithelial cell line (RC170N/h), retain multipotent stem cell properties. The RC-170N/h/clone 7 cells expressed a human embryonic stem cell marker, Oct-4, and potential prostate epithelial stem cell markers, CD133, integrin #alpha#2#beta#1"h"i and CD44. The RC-170N/h/clone 7 cells proliferated in KGM and Dulbecco's Modified Eagle Medium with 10% fetal bovine serum and 5 #mu#g/ml insulin (DMEM + 10% FBS + Ins.) ...
In a recent survey of the stellar populations of LINERS and LINER/HII Transition Objects (TOs) we identified a numerous class of nuclei which stand out because of their conspicuous 10^8-9 yr populations. These objects were called ``Young-TOs'', since they all have TO-like emission line ratios. In this paper we investigate the radial variations of spectral properties in Low Luminosity AGN. Our analysis is based on high S/N, 3500-5500 A, long-slit spectra for 47 galaxies. The data probe distances of typically up to 850 pc from the nucleus with a resolution of ~ 100 pc and S/N ~ 30. Stellar population gradients are mapped by the radial profiles of absorption line equivalent widths and colours along the slit. These variations are further analyzed by means of a decomposition of each spectrum in terms of template galaxies representative of very young (<= 10^7 yr), intermediate age (10^8-9 yr) and old (10^10 yr) populations. Our main findings are: ...
The stellar disc kinematics in a sample of fifteen intermediate- to late-type edge-on spiral galaxies are studied using a dynamical modeling technique. The sample covers a substantial range in maximum rotation velocity and deprojected face-on surface brightness and contains seven spirals with either a boxy- or peanut-shaped bulge. Dynamical models of the stellar discs are constructed using the disc structure from $I$-band surface photometry and rotation curves observed in the gas. The differences in the line-of-sight stellar kinematics between the models and absorption line spectroscopy are minimized using a least-squares approach. The modeling constrains the disc surface density and stellar radial velocity dispersion at a fiducial radius through the free parameter $\\sqrt{M/L}$ $(\\sigma_{\\rm z}/\\sigma_{\\rm R})^{-1}$, where $\\sigma_{\\rm z}/\\sigma_{\\rm R}$ is the ratio of vertical and radial velocity dispersion and $M/L$ the disc ...
% In this work we investigated, in the Smooth Particle Hydrodynamics (SPH) framework, the development of spiral structures and shock fronts in the radial flow of accretion discs in close binary systems. These shock waves take place when the initially supersonic radial flow penetrating the disc bulk, reduces substantially its speed becoming suddenly subsonic. To this purpose, keeping constant the mass of the compact primary (M1 = 1 MO ), the separation between the two components and the injection speed at the inner Lagrangian point L1 (close to the local sound speed), we carried out 2D SPH simulations for four values of the stellar mass ratio M2/M1. We worked out 2D models because the damping effect of the artificial viscosity is too strong in 3D. Furthermore, the 2D environment seems the most suitable in order to evidence shock fronts in highly compressible gases. The results show that spiral structures and shock fronts develop for low values ...
The numerical calculation of oscillatory wavefunctions occurring in the theory of electron scattering from positive ions is considered, the aim being to develop methods for evaluating the oscillatory solutions using a logarithmic grid. Thus, the permitted step-size for the solution depends only upon the potential, enabling calculations at different energies to be performed using the same discretisation. Two similar generalisations of the W.K.B. transformation for second order ordinary differential equations are made and applied to the radial Dirac equations. Iterative schemes for the solution of the resulting non-linear amplitude equations are discussed, one for use in the asymptotic region and the other a Newton scheme for continuing the solution closer to the origin. Using these techniques a reliable and efficient program for calculating relativistic scattering phase shifts from ionic potentials has been written. Relativistic Optical Model problems have been ...
Optimal capacitor placement determines the size, type, and location of capacitors to be installed on a radial distribution feeder that will reduce peak power and energy losses while minimizing the costs of investment and installation of the capacitor banks. This paper describes a sensitivity-based optimal placement of capacitors that employs a new load characterization scheme using a voltage-current-angle-logger. The proposed method allows modeling of loads of different power factors for different portions of the distribution feeder. The optimal solution is obtained by testing various combinations of capacitor banks (based on the smallest bank size specified by the user) and candidate nodes along the distribution feeder, and calculating the resultant savings. In order to reduce solution time, the candidate nodes are ranked according to their sensitivity factors. The highest ranking nodes are considered first in the optimization process. At a node where the ...
The macroscopic rotation of plasma in a toroidal containment device is an important feature of the equilibrium. Toroidal and polidal rotation in the high-beta tokamak Torus II is measured experimentally by examining the Doppler shift of the 4685.75 A He II line emitted from the plasma. The toroidal flow at an average velocity of 1.6 x 10/sup 6/ cm/sec, a small fraction of the ion thermal speed, moves in the same direction as the toroidal-plasma current. The poloidal flow follows the ion diamagnetic current direction, also at an average speed of 1.6 x 10/sup 6/ cm/sec. In view of certain ordering parameters, the toroidal flow is compared with predictions from neoclassical theory in the collisional, Pfirsch-Schluter regime. The poloidal motion, however, results from an E x B drift in a positive radial electric field, approaching a stable ambipolar state. This radial electric field is determined from theory by using the measured poloidal velocity. ...
The macroscopic rotation of plasma in a toroidal containment device is an important feature of the equilibrium. Toroidal and poloidal rotation in the high beta tokamak Torus II is measured experimentally by examining the Doppler shift of the 4685.75 A He II line emitted from the plasma. The toroidal flow at an average velocity of 1.6 x 10/sup 6/ cm/sec, a small fraction of the ion thermal speed, moves in the same direction as the toroidal plasma current. The poloidal flow follows the ion diamagnetic current direction, also at an average speed of 1.6 x 10/sup 6/ cm/sec. In view of certain ordering parameters, the toroidal flow is compared with predictions from neoclassical theory in the collosional, Pfirsch-Schluter regime. The poloidal motion, however results from an E x B drift in a positive radial electric field, approaching a stable ambipolar state. This radial electric field is determined from theory by using the measured poloidal velocity. ...
The performance of the new combustor was tested. Experiments showed that this combustor has superior insulating quality than the previous one. Measured radial concentrations indicated uniform distribution of the primary fuel (coal) inside the fire tube resulting in reasonably flat concentration profiles. However, measured radial concentrations after the addition of the reburn fuel showed uneven distribution of the fuel resulting in parabolic concentration profiles, an indication of insufficient mixing in the reburn zone. In order to study mechanisms of nitrogenous species destruction in the reburn zone, it is necessary to achieve adequate mixing if the assumption of one dimensional plug flow behavior is to be valid. Thus, it became necessary to modify the injector design and the injection mode of the reburn fuel to achieve an adequate level of mixing which is the focus of this report. The results show that a minimum reburn fuel jet velocity of ...
It is well known that composite armors, consisting of glass elements confined with metallic tampers, are extraordinarily effective against shaped charge attack. Early experiments showed that jets fired against glass targets appeared to be bombarded by tiny fragments that destroyed alignment and reduced residual jet penetration. This result was attributed to an elastic rebound effect in which the outward radial motion of the target around the jet periphery was supposed to be arrested by tensile hoop stresses which developed behind the divergent shock front. Glass fragments were then accelerated radially inward and these destabilized the jet. To sustain the large tensile hoop stresses required, the glass must not have been fractured by the initial shock, behind which the stress state is typically well above the Hugoniot elastic limit. Modeling the penetration of a jet into glass requires not only determining the spall strength, i.e., the tensile ...
A parametric experimental investigation of an 85 millimeter bore angular contact ball bearing running in RP-1 fuel was performed at speeds of 10,000 to 24,000 rpm. Thrust loads were varied from 4450 to 17,800 Newtons (1000 to 4000 lbs.). Radial loads were varied from 1335 to 13,350 Newtons (300 to 3000 lbs.). RP-1 lubrication for the bearing was provided through a stationary jet ring located adjacent to the test bearing outer ring. Increases in both the thrust and radial loads resulted in increased bearing temperature, while increases in shaft speed resulted in much more dramatic increases in bearing temperature. These trends are typical for ball bearings operating under these types of conditions. Results are given for outer ring temperatures of the test bearing at the various test conditions employed. In addition, the heat energy removed from the bearing by the RP-1 was determined by measuring the increase in temperature as the RP-1 passed ...
The Moderator Temperature Coefficient of reactivity (MTC) was earlier proven to be properly determined via noise analysis when the neutron noise is measured locally and when the radial average of the moderator temperature noise is used. Nevertheless, measurements revealed that the MTC was correctly estimated on a much narrower frequency band (0.6 - 0.7 Hz) than expected (0.1 - 1.0 Hz). The present paper investigates the effect of the feedback on the MTC determination using this new MTC noise estimator (which could explain the deviation at low frequencies, i.e. between 0.1 - 0.5 Hz) and the effect of the detector time constants (which could explain the deviation at high frequencies, i.e. between 0.7 - 1.0 Hz). For that purpose, a coupled neutronic/thermalhydraulic model of the Ringhals-3 PWR is developed in the frequency-domain, based on a radial 2-dimensional heterogeneous representation of the core. The transfer function of the detectors is ...
Detailed spray characteristics were obtained for a small-capacity, pressure-swirl atomizer using an Aerometrics phase-Doppler particle analyzer. Measurements included drop size and velocity distributions, liquid volume fluxes, and air velocities at four axial locations, 25,50,75, and 100 mm, with complete radial traverses at each location. Drop size results were compared with measurements from a Malvern laser-diffraction instrument, and integrated liquid volume fluxes were compared with measured flow rates to estimate measurement uncertainties. Drop sizes measured by the two independent techniques and area-weighted-averaged over the radial traverses at each of the four axial stations varied on average by less than 4 percent. Integrated volume flux measurements by the phase-Doppler instrument at four axial stations differed from the nozzle flow rate by at most 19 percent, with some of the difference due to evaporation. The phase-Doppler data ...
The thermal and heat transfer characteristics of stearic acid during the solidification processes were investigated experimentally in a vertical annulus energy storage system. The temperature distribution and temperature variations with time at different radial positions during the freezing processes were obtained. The thermal characteristics of the stearic acid, including movement of the solid-liquid interface in the radial direction, and the effects of Reynolds number on the heat transfer parameters were studied. The heat flux was estimated by using a simple approximate model. A new copper fin was designed and fixed to the electrical heating rod to enhance the thermal conductivity of the stearic acid. The results show that the new fin can enhance both the conduction and the natural convection heat transfer of the PCM, and the enhancement factor during solidification is estimated to be as high as 250%. The effect of the fin width on the ...
The thermal and heat transfer characteristics of stearic acid during the solidification processes were investigated experimentally in a vertical annulus energy storage system. The temperature distribution and temperature variations with time at different radial positions during the freezing processes were obtained. The thermal characteristics of the stearic acid, including movement of the solid-liquid interface in the radial direction, and the effects of Reynolds number on the heat transfer parameters were studied. The heat flux was estimated by using a simple approximate model. A new copper fin was designed and fixed to the electrical heating rod to enhance the thermal conductivity of the stearic acid. The results show that the new fin can enhance both the conduction and the natural convection heat transfer of the PCM, and the enhancement factor during solidification is estimated to be as high as 250%. The effect of the fin width on the ...
This paper deals with electron flux densities and electron energy flux densities in positive column discharges. Recent kinetic calculations by Uhrlandt and Winkler have revealed the interesting physical phenomenon of radially inward directed energy flux densities in positive column plasmas. We have used a self-consistent positive column model, based on an accurate and highly detailed Monte Carlo code, to study this effect in more depth. The results of this study show a rather complex physical picture of electron particle and energy flux densities. Electrons with low energies usually exhibit radially outward directed particle and energy flux densities. At energies above the threshold for electronic excitation particle and energy flux densities are usually inward directed. Only close to the wall, at total energies above the wall potential energy, do these flux densities point towards the wall. The thickness of this 'wall loss ...
A study on development of magnetic drive packless valves for commercial purpose showed the results as follows; 1. Study on the radial rays effecting to the permanent magnets -Measurement of the strength of Nd-magnets according to irradiation of radial rays. 2. Effects of temperature on the magnetic driving device -Temperature dependency of the Nd-casting magnets. -Effects of temperature on the heat releasing fins of high-temperature valve. 3. Optimization of torque -Arranging method of permanent magnets -Measuring method and results of torque. 4. Design, manufacture and test for the pressure-resisting structure of magnetic power transmitting device -Calculation and design for the flat circular plates under pressure of the magnetic power transmitting device -Design, manufacture and test for the pressure-resisting structure of magnetic power transmitting device -Comparison of the characteristics between magnetic drive valve and ...
We model the transport of cosmic ray nuclei in the Galaxy by means of a new numerical code. Differently from previous numerical models we account for a generic spatial distribution of the diffusion coefficient. We found that in the case of radially uniform diffusion, the main secondary/primary ratios (B/C, N/O and sub-Fe/Fe) and the modulated antiproton spectrum match consistently the available observations. Convection and re-acceleration do not seem to be required in the energy range we consider: $1 \\le E \\le 10^3$ GeV/nucleon. We generalize these results accounting for radial dependence of the diffusion coefficient, which is assumed to trace that of supernova remnants. While this does not affect the prediction of secondary/primary ratios, the simulated longitude profile of the diffuse $\\gamma$-ray emission is significantly different from the uniform case and may agree with EGRET measurements without invoking {\\it ad hoc} assumptions on ...
Abstract in english In this work the air flow in a furnace was computationally investigated. The furnace, for which experimental test data are available, is composed of a movable block burner connected to a cylindrical combustion chamber by a conical quarl. The apertures between the movable and the fixed blocks of the burner determine the ratio of the tangential to the radial air streams supplied to the furnace. Three different positions of the movable blocks were studied at this time. A thr (more) ee-dimensional investigation was performed by means of the finite volume method. The numerical grid was developed by the multiblock technique. The turbulence phenomenon was addressed by the RNG k-epsilon model. Profiles of the axial, tangential and radial velocities in the combustion chamber were outlined. The map of the predicted axial velocity in the combustion chamber was compared with a map of the experimental axial velocity. The internal space ...
We point out that the moduli sector of the $(2,2)$ string compactification with its nonperturbatively preserved non-compact symmetries is a fertile framework to study global topological defects, thus providing a natural source for the large scale structure formation. Based on the target space modular invariance of the nonperturbative superpotential of the four-dimensional N=1 supersymmetric string vacua, topologically stable stringy domain walls are found. They are supersymmetric solutions, thus saturating the Bogomolnyi bound. It is also shown that there are moduli sectors that allow for the global monopole-type and texture-type configurations whose radial stability is ensured by higher derivative terms.
The All Union Scientific Research Institute of Drilling Techniques has developed the SH01-195 spindle deflector designed for use with the 195 millimeter turbodrill sections in place of the standard spindle. This spindle deflector is an axial support for the turbodrill, manufactured as a separate unit that attaches to the turbosections using the standard attachment configuration for series manufactured turbodrills, using the sub for attachment to the frame and a splined half coupling for attachment to the shaft. The spindle deflector itself consists of two parts connected by a curved sub through the frame and by a double hinge to the shaft. The hinge is isolated from axial forces by mounting radial support ball bearings above and below it.
Muonic-atom energy levels and wave functions are calculated. The results are corrected for nearly all important static effects, including finite nuclear size as produced by a user-specified nuclear charge distribution. Fourth-order Runge-Kutta integration of the radial Dirac equations, with the secant method determining the eigenvalues. Corrections are either included as potentials in the Dirac equations or computed as first-order perturbations. The code assumes spherical symmetry, so that effects of nuclear deformation may be treated only as static first-order perturbations. Dynamic muon-electron and muon-nuclear effects are neglected (the latter are calculated by RURP). (Auth.).
This paper describes the design of a high-voltage negative ion source based on a magnetically insulated diode and generating microsecond pulses. Plane an cylindrical cathodes have been tested. The spatial and angular distributions of negative ions in the beam have been measured. The content of negative ions with different masses in the beam are given. The ion current density measured by a Faraday cup was up to 1 A/cm{sup 2} for the radial beam and 30-40 A/cm{sup 2}.
A catalytic trap oxidizer based on a radial flow metal mesh filter was developed for use as an after treatment device on light-duty diesel vehicles. A complete system for assisted regeneration was devised to enable this unit to operate without blocking during all normal driving modes. The integration of the catalyzed trap and regeneration system with the vehicle to provide a practical system for the reduction of diesel particulate emissions is discussed. To date, many prototype catalytic trap and regeneration system installations have been completed on various test vehicles, both naturally aspirated and turbocharged. The operational conditions and test results from a selection of these studies are presented.
The JUPITER-II Program is the Joint Physics Large Heterogeneous Core Critical Experiments Program between the U.S. Department of Energy (US DOE) and PNC, Japan. The experiments began in May 1982 and ended in April 1984, as a part of the ZPPR-13 program. The ZPPR-13 is a series of critical assemblies designed to study the fundamental neutronic behavior of large, radially-heterogeneous LMFBR cores. This report describes the results of analysis of ZPPR-13A and preliminary analysis of ZPPR-13B, and some topics of recent activities in fast reactor physics.
We present radial velocity and photometry for four early-type, massive double-lined spectroscopic binaries in the R136 cluster. Three of these systems are eclipsing, allowing orbital inclinations to be determined. One of these systems, R136-38 (O3 V + O6 V), has one of the highest masses ever measured, 57 Mo, for the primary. Comparison of our masses with those derived from standard evolutionary tracks shows excellent agreement. We also identify five other light variables in the R136 cluster which are worthy of follow-up study.
A method for the determination of different ''bare'' characteristics of the one-particle motion and one-particle basis in magic nuclei is described. The method is based on separating out the mixing with phonons from the phenomenological one-particle characteristics. By means of a generalization of the procedure for localization of the mass operator, relations linking the bare and phenomenological characteristics are obtained. The radial dependence of these characteristics in finite nuclei and the influence of the quasiparticle--phonon interaction on the phenomenological characteristics are studied. Calculations are performed for the neutrons in /sup 208/Pb.
The mass distribution of the Sombrero Galaxy, NGC 4594, is calculated in order to investigate the suspicion that the rotational velocity of the galactic gas does not measure the circular velocity in the galaxy. It is shown that the H II rotation velocities are much less than circular in the central 35 arcsec of the galaxy, and that the suspicion is correct. Thus, the H II rotation velocities cannot be used to measure the mass distribution. The absorption-line rotation curve is used to derive the mass distribution, and it is found that the M/L ratio is nearly constant. It is concluded that the visible matter is self-gravitating at least in the central 180 arcsec. 44 references.
To investigate the magnetic fluctuations and for further transport study, the poloidal and radial magnetic field measurement is conducted on the Sino United Spherical Tokamak (SUNIST). Auto-power spectral density indicates that the magnetic fluctuation energy mainly concentrates in the frequency region lower than 10 kHz. The magnetic field oscillations, which are characterized by harmonic frequencies of 40 kHz, are observed in the scrape-off layer; by contrast, in the plasma core, the magnetic fluctuations are of Gaussian type. The time-frequency profiles show that the poloidal magnetic fluctuations are temporally intermittent. The autocorrelation calculation indicates that the fluctuations in decorrelation time vary between the core and the edge. (authors)
The combined magnetic braking-ambipolar diffusion problem in weakly ionized, rigidly rotating disks is studied. An analytical solution is presented for a disk whose angular velocity and magnetic yield vectors are aligned with the symmetry axis, illustrating the effects of the relative azimuthal drift of neutrals and ions. The effects of radial drift are added, commenting on the ratio of the characteristic ambipolar diffusion and magnetic braking time scales in high-mass and low-mass disks. A numerical calculation is used to show the combined action of these two processes. 31 references.
In drift tube linacs a beam energy spread results form the finite beam size. Radial variation of the axial accelerating field induces a beam energy spread, which, in general, will accumulate as the beam passes through successive drift tubes. This paper shows that under some conditions of periodic transverse focusing and longitudinal phase focusing, the correlation between the longitudinal and transverse motion can be used to correct the energy spread. The process of achieving such a correction is first described in a simplified situation, and then demonstrated for a particular tuning using a ray-tracing program which models a low velocity and low charge state linac designed for radioactive ion beams.
Exact solutions are found for the Chandrasekhar Page angular equation which results when the Dirac equation in a Kerr Newman space time is separated into its radial and angular parts. The solutions turn out to be remarkably simple in form while satisfying the asymptotic conditions deduced earlier. The eigenvalues are found to be the square root of the total angular momentum as first found by Dirac for flat space; supplemented by a term which is the product of the mass of the Dirac particle times the specific angular momentum of the black hole. The additional contribution is what is expected from frame dragging.
Stabilized formation temperatures were estimated at different depths in 40 wells from the Los Humeros geothermal field, Mexico, using the Horner and the spherical radial flow (SRF) methods. The results showed that the Horner method underestimates formation temperatures, while the SRF method gives temperatures that are closer to the true formation temperatures. This was supported by numerical simulation of a combined circulation and shut-in period in several wells, and results for well H-26 are presented. Numerical reproduction of logged temperature is more feasible if an initial temperature profile based on the SRF method is employed instead of using an initial temperature profile based on the Horner method. (Author)
A nanoparticle generator based on the principle of electrical discharge (PALAS GFG-1000) was used to produce nanoparticles of different chemical natures. The fractions of electrically neutral particles were then measured by means of a Spectrometre de Mobilite Electrique Circulaire (SMEC, i.e. radial-flow mobility analyzer) for different operating conditions. The experimental results were compared with the theoretical values calculated from the Fuchs extended charge equilibrium model for spherical particles and agglomerates. For the smallest particles (below 20 nm), the deviations observed remain below 10%, and tend towards 20% for larger particles (over 35 nm).
We find a large family of solutions to the Dirac equation on a manifold of $G_2$ holonomy asymptotic to a cone over $S^3 \\times S^3$, including all radial solutions. The behaviour of these solutions is studied as the manifold developes a conical singularity. None of the solutions found are both localised and square integrable at the origin. This result suggests that M-theory on the conifold over $S^3\\times S^3$ does not produce a chiral theory. The approach here is complementary to previous analyses using dualities and anomaly cancellation which found chiral fermions on all known $G_2$ conifolds except that over $S^3\\times S^3$.
Toroidal Alfven eigenmodes (TAE) destabilized by the pressure gradient of energetic alpha particles may expel the alpha particles before thermalization. TAE is important for tokamaks, and for helical systems (stellarators) as well. In CHS (compact helical system) TAE localized in the plasma core are destabilized when the plasma current is induced by co-injection of neutral beams. The observed TAE exhibits a ballooning nature. The internal structure of TAE was measured with a soft X-ray detector. The soft X-ray fluctuations level for TAE is too low to obtain the radial profiles of fluctuation intensities. (Tanaka, M.)
The validity is given to the newly proposed two {delta}f method for neoclassical transport calculation, which can be solve the drift kinetic equation considering effects of steep plasma gradients, large radial electric field, finite banana width, and an orbit topology near the axis. The new method is applied to the study of ion transport with steep plasma gradients. It is found that the ion thermal diffusivity decreases as the scale length of density gradient decreases, while the ion particle flux due to ion-ion self collisions increases with increasing gradient. (author)
The method of augmented plane wave (APW) is used to obtain the band structure of the SmS compound in the semiconductor and metal phases. The noncentral part of the Coulomb electron-electron interaction is taken into account in the first order perturbation theory. In this case the radial part of the wave APW-function is taken as a zero approximation function. A multiplet structure of the excited configuration f"5d, which provides a good description of the X-ray photoelectron spectrum and optical spectrum epsilon_2(#omega#), is obtained. The configuration fd is calculated for the interpretation of the optical absorption spectrum of the samarium monosulfide metal phase. (author).
A method of using gamma radiation to determine the density and phase distribution in two-phase flows in pipes is described. Three collimated beams of radiation that pass through a pipe cross-section at different radial positions are used. A theory and computer program used to relate the measured attenuation of these beams to a three-parameter model of the phase distribution and to the average density and void fraction are discussed. Data obtained during both static and dynamic verification experiments using Lucite inserts are presented, as well as the results of several tests done in high pressure, steam-water flows.
Network reconfiguration is an operation problem, which entails altering the topological structure of the distribution feeders by rearranging the status of switches in order to obtain an optimal configuration in order to minimise the system losses. This paper presents a new reconfiguration algorithm that enhances voltage stability and improves the voltage profile besides minimising losses without incurring any additional cost for installation of capacitors, tap changing transformers and related switching equipment in the distribution system. Test results on a 69 node distribution system reveal the superiority of this algorithm.
A large acceptance, high stopping power Bragg curve spectrometer has been developed for use in coincidence experiments with heavy ions. The electron collection fields are radial and position information is obtained from a resistive anode. The detector is 60 cm deep and operates at pressures of up to 2.5 atm of P-10 gas. It is mated to a scattering chamber which allows it to be moved out of plane during coincidence measurements. Factors affecting the performance of the detector are discussed, and results obtained with the detector are presented. (orig.).
A large acceptance, high stopping power Bragg curve spectrometer has been developed for use in coincidence experiments with heavy ions. The electron collection fields are radial and position information is obtained from a resistive anode. The detector is 60 cm deep and operates at pressures of up to 2.5 atm of P-10 gas. It is mated to a scattering chamber which allows it to be moved out of plane during coincidence measurements. Factors affecting the performance of the detector are discussed, and results obtained with the detector are presented. (orig.).
The herbicide atrazine is a known immunotoxicant and an inhibitor of human natural killer (NK) cell lytic function. The precise changes in NK cell lytic function following atrazine exposure have not been fully elucidated. The current study identifies the point at which atrazine exerts its affect on the stepwise process of human NK cell-mediated lyses of the K562 target cell line. Using intracellular staining of human peripheral blood lymphocytes, it was determined that a 24-h in vitro exposure to atrazine did not decrease the level of NK cell lytic proteins granzyme A, granzyme B or perforin. Thus, it was hypothesized that atrazine exposure was inhibiting the ability of the NK cells to bind to the target cell and subsequently inhibit the release of lytic protein from the NK cell. To test t...
Introduction: Haploidentical transplantation, with extensive T cell depletion to prevent GvHD, is associated with a high incidence of infection-related deaths. The key challenge is to improve immune recovery with allogeneic donor T cells without triggering GvHD. As T regulatory cells (Tregs) controlled GvHD in pre-clinical studies, the present study evaluated the impact of an infusion of donor CD4/CD25 + Tregs, followed by an inoculum of donor mature T cells (Tcons) and positively immunoselected CD34 + cells in the setting of haploidentical stem cell transplantation. Patients and methods: Twenty-eight patients were enrolled in this study (22 AML; 5 ALL; 1 NHL). All received immunoselected Tregs (CliniMACS, Miltenyi Biotec) followed by positively immunoselected CD34 + cells together with Tc...
We present high-quality X-ray scattering experiments on pure water taken over a temperature range of 2 to 77 C using a synchrotron beam line at the advanced light source (ALS) at Lawrence Berkeley National Laboratory. The ALS X-ray scattering intensities are qualitatively different in trend of maximum intensity over this temperature range compared to older X-ray experiments. While the common procedure is to report both the intensity curve and radial distribution function(s), the proper extraction of the real-space pair correlation functions from the experimental scattering is very difficult due to uncertainty introduced in the experimental corrections, the proper weighting of OO, OH, and HH contributions, and numerical problems of Fourier transforming truncated data in Q-space. Instead, we consider the direct calculation of X-ray scattering spectra using electron densities derived from density functional theory based on real-space configurations generated with ...
For the study of radiation biology and its application to radiotherapy, the double differential cross section of electron emission from water vapor induced by 6.0 MeV alpha particle beam is measured. The energy spectra of electrons ranging 7- 10000 eV are detected by the electrostatic analyzer and micro channel plate. The measurements are made at angles between 20 and 160 degrees. With use of this data set, the radial dose distribution in water is calculated by using KURBUC code. It is the Monte Carlo type code of the electron transport process, where the track of the electron is simulated through each individual interactions including elastic scattering, ionization cross section and total excitation cross section in case that electrons with certain energy are put in the liquid-density water. In order to understand the effect of radiation when the particle flux is injected in the human body like radiotherapy using accelerator beam, the dose distribution in the ...
Gyrokinetic particle simulation of edge pedestal formation and plasma rotation dynamics will be presented, and compared with experimental observations. Realistic tokamak edge geometry is used which include separatrix/X-point and material wall from EFIT g-eqdsk data. In order to handle adequately the spatially inhomogeneous electric potential in the scrape-off region, the full-f electron technique is used, in addition to the full-f ions. Monte Carlo neutral particles with wall recycling coefficient will be included self-consistently with the plasma kinetics. Ion-ion Coulomb collisions will be particle, momentum and energy conserving. Energy source for the pedestal and scrape-off plasmas is the heat flow from the core plasma, and the particle source is the ionization of the neutral atoms which are either wall recycled and/or gas puffed. The simulation will be self-consistent with the first principles nonlinear neoclassical and (electrostatic so far) turbulence interactions. Plasma ions ...
A general theoretical approach for the study of the two-dimensional structure of high-n Toroidal Alfven Eigenmodes (TAE) in finite-#beta#, large aspect ratio (R_o/a much-gt 1) tokamak equilibria is presented. Here, n is the toroidal mode number, #beta# = plasma/magnetic pressure, and a(R_o) is the minor (major) radius of the torus. It is shown how the general pseudo-differential boundary value problem for the radial eigenmode structure can be systematically constructed from the local dispersion relation; which is obtained using the ballooning formalism. The TAE modes are characterized by a broad radial envelope, the width of which is independent on the mode number in the general case of monotonic equilibrium profiles. The results on the two-dimensional eigenmode structure are expected to be applicable to drift-type waves. The ballooning transform is generalized here to handle singular eigenfunctions typical of the continuous shear Alfven ...
January, 1992, to October, 1995, sixty-four patients with advanced head and neck cancer underwent head and neck reconstructive surgery using myocutaneous or revascularized flaps; in the same period, all patients were consecutively examined with CT and MRI. Myocutaneous flaps were used in 26 patients: 12 flaps were tubular and 14 linear. Revascularized flaps were used in 38 patients: to repair a large defect in 26 patients (14 latissimus dorsi flaps and 12 temporal muscle flaps) and to repair an oral damage in 12 patients (5 revascularized radial and 7 jejunal flaps). CT and MR images of myocutaneous flaps showed the flaps as fatty areas, repairing large surgical defects, hypodense at CT and hyperintense at MRI, with no post-contrast enhancement. The appearance of revascularized flaps at CT and MRI depends on the characteristics of the structure used to repair the surgical defect: jejunal and radial flaps appeared as mostly fatty thickened ...
January, 1992, to October, 1995, sixty-four patients with advanced head and neck cancer underwent head and neck reconstructive surgery using myocutaneous or revascularized flaps; in the same period, all patients were consecutively examined with CT and MRI. Myocutaneous flaps were used in 26 patients: 12 flaps were tubular and 14 linear. Revascularized flaps were used in 38 patients: to repair a large defect in 26 patients (14 latissimus dorsi flaps and 12 temporal muscle flaps) and to repair an oral damage in 12 patients (5 revascularized radial and 7 jejunal flaps). CT and MR images of myocutaneous flaps showed the flaps as fatty areas, repairing large surgical defects, hypodense at CT and hyperintense at MRI, with no post-contrast enhancement. The appearance of revascularized flaps at CT and MRI depends on the characteristics of the structure used to repair the surgical defect: jejunal and radial flaps appeared as mostly fatty thickened ...
The presence of a high number of activated T cells in the bloodstream and spontaneous proliferation of peripheral blood mononuclear cells in vitro are striking characteristics of human T-cell leukemia...Full Text Available
The article is the second part of a review dealing with latest developments in the area of solar cell technologies and application. Physical principles, design and efficiency as well as advantages and disadvantages of GaAs- and CdS-solar cells are described. Power generation solar cell systems with voltage converters, combined solar cell/solar collector systems and thermoelectric solar systems are presented in the second part of the article.
The herbicide atrazine is a known immunotoxicant and an inhibitor of human natural killer (NK) cell lytic function. The precise changes in NK cell lytic function following atrazine exposure have not been fully elucidated. The current study identifies the point at which atrazine exerts its affect on the stepwise process of human NK cell-mediated lyses of the K562 target cell line. Using intracellular staining of human peripheral blood lymphocytes, it was determined that a 24-h in vitro exposure to atrazine did not decrease the level of NK cell lytic proteins granzyme A, granzyme B or perforin. Thus, it was hypothesized that atrazine exposure was inhibiting the ability of the NK cells to bind to the target cell and subsequently inhibit the release of lytic protein from the NK cell. To test this hypothesis, flow cytometry ...
Cell therapy is a promising novel option for treatment of cardiovascular disease. Because the role of bone marrow-derived circulating progenitor cells (BM-CPCs) after cell therapy is less clear, we...Full Text Available
PCD (programmed cell death) in plants presents important morphological and biochemical differences compared with apoptosis in animal cells. This raises the question of whether PCD arose independently...Full Text Available
Although human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL), the role of viral gene expression in the progression to and maintenance of the...Full Text Available
Bovine leukemia virus (BLV), a retrovirus related to human T-cell leukemia virus types 1 and 2, can induce persistent nonneoplastic expansion of the CD5+ B-cell population, termed...Full Text Available
Solid Oxide Fuel Cell (SOFC) is expected as a new power generation source. The development of SOFC is being conducted by CRIEPI, and so far several reports of the reults were presented. This report examines materials of SOFC. For the purpose, cells were made using some of typical materials and manufacturing processes, and cell performance tests were carried out.
The PVSCAN is an instrument designed to characterize silicon solar cell materials and devices. It performs a host of measurements that yield spatial maps of dislocation density, grain distribution, reflectance, and photoresponses from near-junction and the bulk of a solar cell.
The penetration by moxifloxacin of human neutrophils (polymorphonuclear leukocytes [PMN]) and tissue-cultured epithelial cells (McCoy cells) was evaluated by a fluorometric assay. At...Full Text Available
There is ample evidence suggesting that superantigens may act as a triggering factor in the pathogenesis of rheumatoid arthritis (RA). We investigated whether superantigen could activate T cells in...Full Text Available
SUMMARYThe cytolytic activity of natural killer (NK) cells is regulated by inhibitory receptors that detect the absence of self molecules on target cells. Structural studies of...Full Text Available
The proliferation of stem cell research, conflated with its ethical and moral implications, has led governments to attempt regulation of both the science and funding of stem cells. Due to a diversity...Full Text Available
Embryonic stem cells have the ability to develop into virtually any cell in the body, and may have the potential to treat medical conditions such as diabetes and Parkinsons disease. On August 9, 2001, President Bush announced that for the first time feder...
Background: In North America and Europe, 80% of invasive skin cancers are basal cell carcinoma while 20% are squamous cell carcinoma (SCC). In contrast, African studies reveal a preponderance...Full Text Available
BackgroundSpindle cell carcinoma (SpCC) is a rare microscopic type of cancer of the mouth and oropharynx. Although SpCC is thought to arise from squamous cell carcinoma (SCC), it...Full Text Available
This paper describes a radiation shield verification survey of a large hot cell at the Fast Flux Test Facility (FFTF). The following aspects of the shield test are discussed: description of the FFTF; description of the hot cell; the test procedures; radiation protection, and the test results.
... from Dr. Austin Smith of the Institute for Stem Cell Research, University of Edinburgh) was modified from the CGR8 ... to thank Dr. Austin Smith, the Institute for Stem Cell Research, University of Edinbu...
Human myeloid-lineage cells are refractory to HIV-1 infection. The Vpx proteins from HIV-2 and sooty mangabey SIV render these cells permissive to HIV-1 infection through proteasomal degradation of...Full Text Available
Most genetic changes that promote tumorigenesis involve dysregulation of G1 cell cycle progression. A key regulatory site in G1 is a growth factor–dependent restriction point (R) where cells...Full Text Available
Target of rapamycin (TOR) kinases control cell growth through two functionally distinct multiprotein complexes. TOR complex 1 (TORC1) controls temporal cell growth and is sensitive to rapamycin, whereas...Full Text Available
... based, disease treatment remains promising, the emphasis for stem cell research from the biomedical research community is clear, and ... diagnosis as a novel source of embryos for stem cell research. Repr...
The cells of the endosperm of castor bean seeds (Ricinus communis) undergo programmed cell death during germination, after their oil and protein reserves have been mobilized. Nuclear...Full Text Available
Placental and placental-like alkaline phosphatase (PLAP) levels in the culture media of 87 cell lines of neoplastic and 'normal' origin were measured by a conventional immunosorbent enzymatic assay...Full Text Available
The rate and capacity for chloroform (CF) and trichloroethylene (TCE) transformation by a mixed methanotrophic culture of resting cells (no exogenous energy source) and formate-fed cells were measured....Full Text Available
A new method is described for continuously measuring cell turgor pressure (P), hydraulic conductivity (Lp), and volumetric elastic modulus (ε) in higher plant cells, using a pressure...Full Text Available
PURPOSE: To determine the frequency of ophthalmic abnormalities in patients with cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome) and T-cell lymphoma involving the skin and...Full Text Available
Neutral endopeptidase 24.11 (NEP, CD10) is a cell-surface enzyme expressed by prostatic epithelial cells that cleaves and inactivates neuropeptides implicated in the growth of androgen-independent prostate...Full Text Available
The primary aim of this study was to develop a model system that uses epidermal cells (keratinocytes and accessory pigmented cells) cultured on a reconstituted basement membrane biomatrix for use in...Full Text Available
Amorphous silicon solar cells have been shown to have efficiencies which degrade as a result of long exposure to light. Annealing such cells in air at a temperature of about 200.degree. C. for at least 30 minutes restores their efficiency.
Special red cells were found on the adaxial surface of tertiary pulvini of Mimosa pudica and experiments performed to determine the origin and function of these cells. Using anatomical...Full Text Available
Red cell transfusions are associated with the development of acute lung injury in the critically ill. Recent evidence suggests that storage induced alterations of the red blood cell (RBC) collectively...Full Text Available
Adhesion of Spirogyra (tentatively, Spirogyra fluviatilis) cells to glass is described. The cells of an algal filament can adhere to a substrate only when they are...Full Text Available
Many patients who undergo hematopoietic cell transplantation (HCT) present with anemia and have received red blood cell transfusions before HCT. As a result, iron overload is frequent and appears...Full Text Available
Understanding the interactions between herpesviruses and their host cells and also the interactions between neoplastically transformed cells and the host immune system is fundamental to understanding...Full Text Available
Stem cells of the human prostate gland have not yet been identified utilizing a structural biomarker. We have discovered a new prostatic epithelial cell phenotype-expressing cytokeratin 6a (Ck6a+...Full Text Available
BackgroundStem cells divide to reproduce themselves and produce differentiated progeny. A fundamental problem in human biology has been the inability to measure how often stem cells...Full Text Available
... is known as "reproductive cloning." The Link to Stem Cell Research Stem cell research and research cloning are closely linked. Scientists in ... to arrive at a position on cloning and stem cell research. Many nations, including the UK, China, and South ...
Although most self-reactive T cells are eliminated in the thymus, mechanisms to inactivate or control T cells specific for extrathymic antigens are required and exist in the periphery. By investigating...Full Text Available
The glycolipid content of human non-seminomatous germ cell tumour cell lines correlates with their differentiation lineage. To analyse whether this reflects the situation in primary tumours, we studied...Full Text Available
One of the major decisions that germ cells make during their development is whether to differentiate into oocytes or sperm. In mice, the germ cells’ decision to develop as male or female depends...Full Text Available
DNA from the peripheral blood mononuclear cells of 17 different individuals infected with human T-cell lymphoma/leukemia virus type II (HTLV-II) was successfully amplified by the polymerase chain reaction...Full Text Available
It Peripheral blood progenitor enriched CD34+ cells (PBPC) are rather often used as stem cell background in cancer patients following high dose therapy. Keeping in mind that precursor dendritic cells (DCs) originate from haematopoietic progenitor cells, purified CD34+ cells might also serve as starting cells for ex-vivo production of DC. The aim of the present study is to develop a clinical grade procedure for ex-vivo production of DC derived from enriched CD34+ cells. Various concentrations of CD34+ cells were grown in gas-permeable Teflon bags with different serum-free and serum-containing media supplemented with GM-CSF, IL-4, TNF-a, SCF, Flt-3L and INF-a. Serum-free CellGroSCGM medium for 7 days followed by CellGroDC medium in 7 days gave equal results as serum-containing ...
Metastatic testicular germ cell tumours are cured in approximately 85% of patients using cisplatin-based combination chemotherapy. Patients who fail to respond have a poor prognosis, and there is a...Full Text Available
The first cell lineage specification in mouse embryo development is the formation of trophectoderm (TE) and inner cell mass (ICM) of the blastocyst. This article is to review and discuss the...Full Text Available
Zygotes of fucoid algae have long been studied as a paradigm for cell polarity. Polarity is established early in the first cell cycle and is then expressed as localized growth and invariant cell division....Full Text Available
Naturally occurring and contaminant ferromagnetic and ferrimagnetic particles have been found within or near cells, and might allow pulsed magnetic fields to create transient cell membrane opening ("pores")....Full Text Available
BackgroundClara cell protein (CC16), the main secretory product of bronchiolar Clara cells, plays an important protective role in the respiratory tract against oxidative stress and...Full Text Available
... ions. MATERIALS AND METHODS Cell Culture Culture of NT2/D1 cells was carried out as described previously (18, 19). NT2 cells were plated at a density of 2. ... ...
BackgroundPerfluorocarbons (PFC) are used to improve gas exchange in diseased lungs. PFC have been shown to affect various cell types. Thus, effects on alveolar type II (ATII) cells...Full Text Available
1. Paired or single recordings of paraventricular and/or supraoptic oxytocin cells at the beginning of suckling in urethane-anaesthetized rats enabled us to study cell recruitment and compare the characteristics...Full Text Available
Reaggregated cells from 6- to 8-day-old mouse cerebella have been used to raise antibodies in rabbits. The interaction of these antibodies with cerebellar cell surface components was assessed by cytotoxicity...Full Text Available
Cells have an internal compass that enables them to move along shallow chemical gradients. As amoeboid cells migrate, signaling events such as Ras and PI3K activation occur spontaneously on pseudopodia....Full Text Available
The cell types involved in the cellular immune response were studied with the GVH in vitro as a test system. Comparison of the activities of cells of different lymphoid organs in the...Full Text Available
Species differences in lifespan have been attributed to cellular survival during various stressors, designated here as ‘cell resilience’. In primary fibroblast cultures, cell...Full Text Available
Stem cell therapies for neurodegenerative disorders require accurate delivery of the transplanted cells to the sites of damage. Numerous studies have established that fluid injections to the hippocampus...Full Text Available
We review the application of C. elegans as a model system to understand key aspects of stem cell biology. The only bona fide stem cells in C. elegans...Full Text Available
One of the main obstacles encountered when trying to culture human seminoma (SE) cells in vitro is massive degeneration of the tumour cells. We investigated whether dissociation of tumour tissue, to...Full Text Available
SummaryFor mammalian somatic cells the importance of microtubule cytoskeleton integrity in interphase cell cycle progression is uncertain. The loss, diminishment, or stabilization...Full Text Available
BACKGROUND--Interstitial lung diseases are characterised by the recruitment of mononuclear cells to disease sites where maturation occurs and activation products, including lysozyme (LZM), are released....Full Text Available
BackgroundA fundamental requirement for the exploitation of embryonic stem (ES) cells in regenerative medicine is the ability to reproducibly derive sufficient numbers of cells of...Full Text Available
Cultured mouse or human embryonic stem (ES) cells provide access to all of the genes required to elaborate the fundamental components and physiological systems of a mammalian cell. Chemical or insertional...Full Text Available
ObjectiveThe goal of the study was to investigate the genetic and molecular basis of a novel syndrome of marked hyperglucagonemia and pancreatic α cell hyperplasia...Full Text Available
Fate maps are generated by marking and tracking cells in vivo to determine how progenitors contribute to specific structures and cell types in developing and adult tissue. An advance in this...Full Text Available
It may result in acute radiation syndrome after body is exposed to ionizing radiation. The one of long-term effects of irradiation injury is leukemia. The bone marrow cells (BMC) transplantation including stem cells is the only effective therapy for acute radiation syndrome patients. Recently, with the advancement of stem cell research that the stem cells have multipotential and can convert each other, it may supply the new stem source for the irradiation injury patients. At the same time with the further research of radioprotective reagents, the hematopoietic stem cells proliferation after irradiation injury is promoted
In the last two years, rapid progress has been made in the energy conversion efficiencies of GaAs solar cells fabricated from molecular beam epitaxy (MBE) material. The efficiencies of cells fabricated from MBE material are now comparable with those fabricated from metal-organic chemical vapor deposition material, even for cells of dimension 2 cmx4 cm. This paper reviews the progress in MBE cell efficiencies. Also discussed is the role oval defects play in GaAs diode and solar cell performance. (orig.).
As concern regarding global environmental problems such as the greenhouse effect and acid rain has increased, so too has the demand for commercially viable solar cells as a clean energy source. Interest in amorphous silicon (a-Si) solar cells has been particularly high, due to their low cost. Technological developments in the field of a-Si solar cells are discussed from the viewpoints of fabrication process, materials, and cell structures. Various applications and systems that take advantage of the a-Si solar cell are then introduced. Finally, future prospects are mentioned
Transdifferentiation of an individual's own cells into functional differentiated cells to replace an organ's lost function would be a personalized approach to therapeutics. In this two part series, we will describe the progress toward establishing functional transdifferentiated adrenal cortical cells. In this article (Part 2), we describe the disorders of the adrenal cortex, therefore establishing why there is the need for personalized cell-based therapy for individuals with these disorders. We then present our pilot studies of cell transdifferentiation toward an adrenal cortical fate using genes described in the first article of this pair (Part 1).
In this contract, Laser-assisted processing techniques for producing high-quality solar cell metallization patterns are being investigated, developed, and characterized. The tasks comprising these investigations are outlined. Four new batches of solar cells were processed, in addition to several test runs on wafers, using the laser decomposition of spun-on silver neodecanoate to metallize cells. Decomposition of silver neodecanoate was carried out at different laser powers on different cells on a given wafer to determine whether this would have any effect on cell performance. A one watt laser power gave an electroplated linewidth of 50 microns , while at 8 watts the line width was 90 microns.
We report on multijunction GaInP/GaAs photovoltaic cells with total-area efficiencies of 29.5% at one-sun concentration and air mass (AM) 1.5 global and 25.7% one-sun, AM0. These values represent the highest efficiencies achieved by any solar cell under these illumination conditions. Three key areas in this technology are identified and discussed: the grid design, front surface passivation of the top cell, and bottom surface passivation of both cells. Aspects of cell design related to its operation under different solar spectra and under concentration are also discussed.
The theory for the general case of solar cells operating inside integrating cavity receivers is established. This is applied to the particular case of different configurations of silicon and GaAs cells. The results of the analysis show that a composite system of silicon and GaAs cells manufactured using relatively simple technology could reach an efficiency of 34%. The optimal configuration is that in which the GaAs cells are placed in the directly illuminated area of the receiver and the silicon cells are placed in the indirectly illuminated area of the receiver. (orig.).
pletely new PW fuel cell model had to be developed for CINDA. Several ...... following linear equation, which is used in the SINDA fuel cell model: ...
ObjectiveTo achieve osteochondral regeneration utilizing transplantation of cartilage-lineage cells and adequate scaffolds, it is essential to characterize the behavior of transplanted...Full Text Available
BackgroundThe evolution of eukaryotic cells is widely agreed to have proceeded through a series of endosymbiotic events between larger cells and proteobacteria or cyanobacteria,...Full Text Available
The molecular structure, chemical properties, and biological function of the xyloglucan polysaccharide isolated from cell walls of suspension-cultured sycamore (Acer pseudoplatanus)...Full Text Available
... Program: Quallion Matrix Design (small cells) - Investigate the feasibly of a hybrid battery matrix composed of small D-sized cells for use in HEVs ...
The most advanced frontier of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is represented by the use of an HLA-partially matched relative as donor. In this type of transplantation, donor-derived natural killer (NK) cells, which are alloreactive towardtoward recipient cells, significantly contribute to the eradication of leukemia blasts. Alloreactive NK cells may also kill host dendritic cells and T lymphocytes, thus preventing graft-versus-host disease and graft rejection, respectively. Sophisticated strategies of adoptive infusion of T-cell lines/clones specific for the most life-threatening pathogens (namely cytomegalovirus, Epstein-Barr virus, Aspergillus and Adenovirus) have been envisaged, and successfully tested in a few pilot trials, to protect the recipient in the...
Gene expression is a fundamentally stochastic process, with randomness in transcription and translation leading to significant cell-to-cell variations in mRNA and protein levels. This variation...Full Text Available
Conditions were found in which Chlamydomonas reinhardi exhibits a circadian alteration of its cell surface, measured as ability to stick to glass. Under these same conditions the cells...Full Text Available
To examine the possibility that mast cells have a central role in the pathogenesis of hypersensitivity pneumonitis, 20 patients with this disease were studied with the aim of seeking evidence for mast...Full Text Available
Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory...Full Text Available
There is a requirement for a noninvasive technique to monitor stem cell differentiation. Several candidates based on optical spectroscopy are discussed in this review: Fourier transform infrared (FTIR)...Full Text Available
Diverse cell polarity networks require positive feedback for locally amplifying distributions of signalling molecules at the plasma membrane1. Additional...Full Text Available
Morphological, Electrophysiological and Behavioral Investigations of the Nervous Tissue Developed from the Embryonic Matrix Zone Cells of the Dorsolateral Walls of Lateral Ventricles, Implanted into the Lesioned Regions of the Adult Rat's Brain
Jun 10, 2011 ... The PSSC is a picosatellite designed to test the space environment by providing a testbed to gather data on new solar cell technologies.
The present volume on modeling of batteries and fuel cells discusses the significance of the effectiveness factor for flooded porous electrodes, active pore distribution spectroscopy for characterizing porous battery electrodes, the agglomerate model for porous electrodes, and dynamic-performance measurements of battery cells for electric vehicles and other applications. Attention is given to mathematical modeling of a primary zinc/air battery, mathematical modeling of Grace Li-TiS2 cells, modeling of electrocrystallization processes in battery systems, and rotating disk electrode studies in molten Li/K carbonate eutectic. Topics addressed include the variability of nickel oxide cathode dissolution in molten carbonate fuel cells, water transport properties of fuel cell ionomers, modeling water content effects in polymer electrolyte fuel cells, and computer ...
Many mutations associated with retinal degeneration lead to the production of misfolded proteins by cells of the retina. Emerging evidence suggests that these abnormal proteins cause cell death...Full Text Available
Methods for improving the sensitivity of scintillation cells for radon concentration measurements were studied with emphasis on improving light collection efficiency. This allows the length and hence the volume of the cell to be increased. Variables studied were choice of scintillator material, its method of application and thickness, length of cell, cell material, type and configuration of reflectors, choice of photomultipliers, and factors affecting background. Response from various areas of the cell surface was studied with an alpha source and with radon filling. Coating the window with phosphor was found to be counter-productive. The optimum results obtained were with the inside of the cell (other than the window) covered with a thick layer of ZnS(Ag), or with a thick layer of reflective material coated with a thin layer of phosphor. With it, a 10 cm ...
Methods for improving the sensitivity of scintillation cells for radon concentration measurements were studied with emphasis on improving light collection efficiency. This allows the length and hence the volume of the cell to be increased. Variables studied were choice of scintillator material, its method of application and thickness, length of cell, cell material, type and configuration of reflectors, choice of photomultipliers, and factors affecting background. Response from various areas of the cell surface was studied with an alphy source and with radon filling. Coating the window with phosphor was found to be counter-productive. The optimum results obtained were with the inside of the cell (other than the window) covered with a thick layer of ZnS(Ag), or with a thick layer of reflective material coated with a thin layer of phosphor. With it, a 10 cm ...
Proliferating cells have been immunophenotypically characterized in lymph node and bronchoalveolar lavage (BAL) samples obtained from patients with active and inactive sarcoidosis with the cell-cycle-related...Full Text Available
Erythrocytes serve as reservoirs for cis- and trans-epoxyeicosatrienoic acids (EETs). Incubation of rat red blood cells (RBCs) with cis- and...Full Text Available
PASTICCINO (PAS) genes are required for coordinated cell division and differentiation during plant development. In loss-of-function pas mutants,...Full Text Available
PurposeTo analyze the expression of apoptosis and cell proliferation molecules in pterygium tissues of Chinese patients.MethodsThirty-three pterygia...Full Text Available
Proton exchange membrane (PEM) fuel cells are energy sources that have the ... for H2 /02 PEM fuel cells because their catalysts have properties suitable for 0 ...
Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo(a)pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors. 2 tabs.
... with the loosening of Bush-era restrictions on stem cell research, a move that was widely hailed by the ... The first two explore the contentious debate over stem cell research. Using a series of intervie...
The existence of stem cells committed to the T lymphoid lineage was deduced from studying how rat T and B stem cells differ in their expression of membrane W3/13 antigen and in their susceptibility in vivo to gamma irradiation. Stem cell activity of rat bone marrow and fetal liver was measured in long-term radiation chimeras using B and T cell alloantigenic surface markers to identify the progeny of donor cells. Monoclonal mouse anti-rat thymocyte antibody W3/13 labeled approximately 40% of fetal liver cells and 60-70% of young rat bone marrow cells (40% brightly, 25% dimly). Bright, dim, and negative cells were separated on a fluorescence-activated cell sorter. All B and T lymphoid stem cells in fetal liver were W3/13 bright, as were B lymphoid stem cells in ...
Cancer, by definition, is a proliferative disease. The fundamental scientific issue explored at the international symposium "Cell Proliferation and Chemical Carcinogenesis" was the impact of chemically...Full Text Available
Cells of the mononuclear phagocyte lineage have the capability to adhere to and fuse with each other and to differentiate into osteoclasts and giant cells. To investigate the macrophage adhesion/fusion...Full Text Available
Abstract: In many biological processes heterogeneity within clonal cell populations is an important issue. One of the most striking examples is a population of cancer cells in which after a common, identical death signal some cells die whereas others survive. The reason for this heterogeneity is intrinsic and extrinsic noise. In this paper we present a mechanistic multi-scale modeling framework for cell populations, in which the dynamics of every individual cell is captured by a parameter dependent stochastic differential equation (SDE). Heterogeneity among individual cells is accounted for by differences in parameter values, modeling extrinsic influences. Based on the statistical properties of the extrinsic noise and the SDE model for the individual cell, a partial differential equation (...
We present a sample preparation method for measuring magnesium in individual whole lymphocytes by electron probe X-ray microanalysis. We use Burkitt's lymphoma cells in culture as the test sample and compare X-ray microanalysis of individual cells with atomic absorption analysis of pooled cell populations. We determine the magnesium peak-to-local continuum X-ray intensity ratio by electron probe X-ray microanalysis and calculate a mean cell magnesium concentration of 39 +/- 19 mmol/kg dry weight from analysis of 100 cells. We determine a mean cell magnesium concentration of 34 +/- 4 mmol/kg dry weight by atomic absorption analysis of pooled cells in three cell cultures. The mean cell magnesium concentrations determined by the two methods are not significantly different. We find a 10% coefficient of ...
May 31, 2011 ... A Theoretical Solid Oxide Fuel Cell Model for System Controls and Stability Design AUTHOR(S): Kopasakis, George; Brinson, Thomas; Credle, ...
The purpose of this review is to consider the hypothesis that cancer frequently originates from stem cells. Using the spleen transplantation assay where stem cells were transplanted in the spleen of mice lethally irradiated by ionizing radiation, the author undertook a study aimed at defining the risk of radiogenic cancer per susceptible cells with use of rat radiogenic mammary and thyroid cancers because of the high incidences of these cancers in a-bomb survivors. Measured were the number of cancer-susceptible cells initially present in the tissue, the number of such cells that survived at a given dose and the number of cancers that developed per surviving cell. Thyroid cell differentiation and proliferation in rats transplanted with thyroid cells were enhanced by thyroidectomy and low iodine diet. Further, the ...
Physiological functions are carried out by differentiated cells, with finite lifespans, which age and need to be replaced. In young individuals, tissue functions are sustained at optimal levels because cellular dysfunction and cell loss are balanced by the emergence of newly differentiated cells as stem cells and their partially differentiated descendants replicate. However, with the passage of time the mitotic rates of these cells diminish. Eventually, replications occur too infrequently to offset the loss. It is at this point that the tissue begins to show structural changes and declining function which, as they become pervasive, are identified as ageing. In this paper the theory is set forth that: (1) Diminishing mitotic activity in older tissues results from limited stem cell replicative capacity. (2) All stem cells, regardless of ...
Bone marrow is one of the most radiosensitive organs. Irradiation causes a marked decrease in the total number of hematopoietic cells in the bone marrow. The reticular meshwork structure of marrow stromal cells, however, is relatively resistant to irradiation. Unimpaired stromal cell structure has been thought to be a prerequisite for the repopulation of hematopoietic cells during recovery from the effects of irradiation. The reticular framework is maintained by cell adhesion apparatuses such as gap junctions. The in vitro radiobiologic survival values of a cloned stromal cell line, H-1/A, were studied (n = 1.8, D0 = 138 cGy). Radiation doses of up to 4000 cGy had no detectable effects on the production of colony-stimulating factor 1. H-1/A cells communicate with each other via gap junctions as determined by the sensitive dye-transfer ...
Bone marrow is one of the most radiosensitive organs. Irradiation causes a marked decrease in the total number of hematopoietic cells in the bone marrow. The reticular meshwork structure of marrow stromal cells, however, is relatively resistant to irradiation. Unimpaired stromal cell structure has been thought to be a prerequisite for the repopulation of hematopoietic cells during recovery from the effects of irradiation. The reticular framework is maintained by cell adhesion apparatuses such as gap junctions. The in vitro radiobiologic survival values of a cloned stromal cell line, H-1/A, were studied (n = 1.8, D0 = 138 cGy). Radiation doses of up to 4000 cGy had no detectable effects on the production of colony-stimulating factor 1. H-1/A cells communicate with each other via gap junctions as determined by the sensitive dye-transfer ...
The cell is modeled as an ellipsoid with shell and the surface stress distribution calculated by means of the Maxwell Stress Tensor. The cell membrane is treated as incompressible material having both bending and shear energies of deformation. Employing the principle of virtual work, cell volume (and hence shape) is computed as a function of the external field strength and orientation with respect to the field. The following results were obtained: (1) The surface stresses that develop or the cell membrane are distributed having both normal and tangential components that act together to produce a rounding of the cell. (2) If the tangential component of the stress is ignored, then higher field strengths are needed to produce similar deformation (shape change) of cells. (3) The threshold value of the applied field, i.e, the field strength at which the volume ...
The field of stem cell research was revolutionized with the advent of induced pluripotent stem cells. By reprogramming somatic cells to pluripotent stem cells, most ethical concerns associated with the use of embryonic stem cells are overcome, such that many hopes from the stem cell field now seem a step closer to reality. Several methods and cell sources have been described to create induced pluripotent stem cells and we discuss their characteristics in terms of feasibility and efficiency. From these cells, cardiac progenitors and cardiomyocytes can be derived by several protocols and most recent advances as well as remaining limitations are being discussed. However in the short time period this technology has been around, evidence emerges that induced pluripotent stem cells may ...
In order to study the neurobiological basis of seasonal changes in hippocampal structure and function, the rate of cell proliferation was examined in male and female wild meadow voles captured during different seasons. We found that the number of [3H]thymidine-labeled cells varied across the seasons and across sex in the meadow vole. Non-breeding female meadow voles had a higher rate of cell proliferation and cell death than males captured during either season or breeding females. These seasonal changes in the female meadow vole were associated with both fluctuating levels of adrenal steroids and gonadal steroids. Estradiol level was highly correlated with both the number of [3H]thymidine-labeled cells and the number of pyknotic cells in female meadow voles, with high levels of estradiol being associated with low levels of cell proliferation ...
The authors describe an effect of suppression of invasion of the guinea pig eye conjunctiva and the HEp-2 epithelial cells by virulent Sh. flexneri bacilli, with a simultaneous administration of the same dose of avirulent shigella mutants, genetically connected with them. The data of morphological study and experiments with 3H-glucose labeled shigellae carried out on the cell species model indicated that the bacterial competition for the specific sites for absorption on the epithelial cells underlay the observed phenomenon. PMID:331774
Hyperosmotic stress is known to significantly enhance net uptake of inorganic ions into plant cells. Direct evidence for cell turgor recovery via such a mechanism, however, is still lacking. In the...Full Text Available
A new fabrication process is being developed which significantly improves the efficiency of metal-semiconductor solar cells. The resultant effect, a marked increase in the open-circuit voltage, is produced by the addition of an interfacial layer oxide on the semiconductor. Cells using gold on n-type gallium arsenide have been made in small areas (0.17 sq cm) with conversion efficiencies of 15% in terrestrial sunlight.
Epidermal gamma delta T cells (γδ T) and Langerhans cells (LC) are immune cells altered by exposure to ultraviolet radiation (UVB), a powerful stressor resulting in immune suppression....Full Text Available
The AT and T Round Cell has recently become a viable alternative to the conventional, rectangular, lead acid storage batteries in Class 1E applications at US nuclear generating stations. This paper discusses the qualification of the Round Cell for nuclear generating stations, its principal design attributes, the types of Class 1E applications most suited for the Round Cell, and industry experience related to its installation and operation.
Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that,...Full Text Available
Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.
IntroductionThe phenotypic and functional differences between cells that initiate human breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to...Full Text Available
The origin of the epithelial and myoepithelial cells in the human breast has not been delineated. In this study we have addressed whether luminal epithelial cells and myoepithelial cells are vertically connected, i.e., whether one is the precursor for the other. We used a primary culture assay allowing preservation of basic phenotypic traits of luminal epithelial and myoepithelial cells in culture. The two cell types were then separated immunomagnetically using antibodies directed against lineage-specific cell surface antigens into at best 100% purity. The cellular identity was ascertained by cytochemistry, immunoblotting, and 2-D gel electrophoresis. Luminal epithelial cells were identified by strong expression of cytokeratins 18 and 19 while myoepithelial cells were recognized by expression of vimentin and ...
Murine embryonic stem (ES) cells have unusually long telomeres, much longer than those in embryonic tissues. Here we address whether hyper-long telomeres are a natural property of pluripotent stem cells,...Full Text Available
The state of chromatin during the cell cycle was examined using synchronized cultures of CHO hamster cells. Results support Mazia's dynamic chromosome cycle model and indicate that DNA-interactive chemotherapeutic agents elicit different types of kinetic responses in treated cells, suggesting a degree of specificity of interaction between various alkylating and intercalating agents and the genome. Effects of sarkosyl crystals, heparin, and chemotherapeutic agents, neocarzinostatin and adriamycin, on chromation are discussed. (HLW)
BackgroundAberrant CD40 ligand (CD154) expression occurs on both T cells and B cells in human lupus patients, which is suggested to enhance B cell CD40 signaling and play a role...Full Text Available
The zinc-air battery/fuel cell is an old technology invented one hundred years ago. However, there is renewed interest in this technology in response to the growing need for clean energy technology. The zinc-air battery/fuel cell is more attractive than similar technologies because its characteristics include high power density, safe operation and storage, and low cost. Zinc-air battery/fuel cells can be made in milliwatts to mega watts to accommodate different applications. The zinc-air battery/fuel cell has four major designs, namely primary, mechanically rechargeable, continuous feed and electrically rechargeable zinc-air battery/fuel cells. Among the different designs, the most common is the air cathode. There are 3 generations of catalysts used in the air cathodes. This paper discussed the different designs of the zinc-air battery/fuel cell, and more ...
Sphere-forming abilities in culture condition are considered a hallmark of cancer stem-like cells, which represents tumor cell invasiveness and stem-like characteristics. We aimed to show that the sphere-forming subpopulation of human malignant melanoma cell line WM-266-4 acts differently to zebrafish embryo extracts compared with their bulk counterpart. Spheres were maintained in neural stem cell culture conditions. The embryos of zebrafish at specific developmental stages were collected and the extracts were purified under 100 kDa. Spheres were treated with embyo extracts and proliferation assay and immunocytochemistry were conducted. Spheroid cells expressed nestin and epidermal growth factor receptor (EGFR) but not melanoma antigen recognized by T-cells (MART)1, indicating their stem-l...
Summary The effects of high-intensity pulsed electromagnetic stimulation (HIPEMS) on proliferation and differentiation of neonatal rat neural stem cells in vitro were investigated. Neural stem cells derived from neonatal rats were exposed to 0.1 Hz, 0.5-10 Tesla (T) [8 groups of B-I, respectively], 5 stimuli of HIPEMF. The sham exposure controls were correspondingly established. Inverted phase contrast microscope was used to observe the cultured cells, MTT assay to detect the viability of the cells as expressed by absorbance (A) value, and flow cytometry to measure differentiation of neural stem cells. The results showed that A values of neural stem cells in both 3.0 T and 4.0 T groups were significantly higher than the other groups 24 to 168 h post HPEMS, indicating a strong promotion of ...
A numerical model is developed to study electrolyte dependent kinetics in fuel cells. The model is based on the Poisson-Nernst-Planck (PNP) and generalized-Frumkin-Butler-Volmer (gFBV) equations, and is used to understand how the diffuse layer and ionic transport play a role in the performance difference between acidic and alkaline systems. The laminar flow fuel cell (LFFC) is used as the model fuel cell architecture to allow for the appropriate comparison of equivalent acidic and alkaline systems. We study the overall cell performance and individual electrode polarizations of acidic and alkaline fuel cells for both balanced and unbalanced electrode kinetics as well as in the presence of transport limitations. The results predict cell behavior based on electrolyte composition that strongly...
Cyclooxygenase-2 (COX-2) content is increased in many types of tumor cells. We have investigated the mechanism by which resveratrol, a stilbene that is pro-apoptotic in many tumor cell lines, causes apoptosis in human head and neck squamous cell carcinoma UMSCC-22B cells by a mechanism involving cellular COX-2. UMSCC-22B cells treated with resveratrol for 24 h, with or without selected inhibitors, were examined: (1) for the presence of nuclear activated ERK1/2, p53 and COX-2, (2) for evidence of apoptosis, and (3) by chromatin immunoprecipitation to demonstrate p53 binding to the p21 promoter. Stilbene-induced apoptosis was concentration-dependent, and associated with ERK1/2 activation, serine-15 p53 phosphorylation and nuclear accumulation of these proteins. These effects were blocked by ...
...Polymer Fuel Cells Challenge Publications News Events Login Register Search Content type All Web pages Case studies Publications News Video Home ...Buildings Carbon capture & storage Combined heat & power Electricity transmission & distribution Energy storage Fuel cells Geothermal Hydroelectric Hydrogen Industry Lighting Marine Metering Nuclear Solar Transport Wind ...Home Emerging technologies Current focus areas Polymer Fuel Cell Challenge Polymer Fuel Cells Challenge The objective of the Polymer Fuel Cells Challenge is to develop,...prove and commercialise novel polymer fuel cell technologies that have the potential to deliver a step-change in overall system cost. What are ...
To determine whether PKH26 labeling affects the morphologies, phenotypes, proliferation, and secretion abilities of human umbilical mesenchymal stromal cells (HUMSCs) were investigated. Isolated HUMSCs were labeled with PKH26, and cell morphology was observed under microscope. Cell cycle, apoptotic cell death, expression of PKH26, and the proliferation rate were evaluated. Additionally, fluorescence intensity of PKH26 labeling at different passage times was quantified. There were no detectable differences in cell morphology, cell growth, and proliferation rate after PKH26 labeling. In addition, fluorescence intensity of PKH26 labeling was gradually reduced with increase of the passage times. The PKH26 labeling disappeared after passage six times. In summary, PKH26 labeling is a safe and ef...
Recent improvements in cell purification and transplantation techniques have contributed to the identification of cell populations known as tumor-initiating cells (TIC). This discovery has led to the -cancer stem cell hierarchy- concept, which holds that tumors are organized as a hierarchy of malignant tissues sustained by such TIC. However, this concept remains controversial. In this review, we examine recent advances in cancer stem cell research that have been generated from studies of Philadelphia (Ph) chromosome-positive leukemia. The abnormal Ph chromosome, which arises from a translocation creating the BCR-ABL1 fusion gene, is most commonly associated with chronic myelogenous leukemia (CML) and precursor B cell acute lymphoblastic leukemia (B-ALL). Examination of the pathophysiology ...
Epigenetic regulations of genes by reversible methylation of DNA (at the carbon-5 of cytosine) and numerous reversible modifications of histones play important roles in normal physiology and development, and epigenetic deregulations are associated with developmental disorders and various disease states, including cancer. Stem cells have the capacity to self-renew indefinitely. Similar to stem cells, some malignant cells have the capacity to divide indefinitely and are referred to as cancer stem cells. In recent times, direct correlation between epigenetic modifications and reprogramming of stem cell and cancer stem cell is emerging. Major discoveries were made with investigations on reprogramming gene products, also known as master regulators of totipotency and inducer of pluoripotency, na...
The key factors of enzymatic lysis of cells are the interaction between the enzyme and the cell - catalytic and non-catalytic adsorption of enzyme on cell surface. Here, the studies of lysis of intact Escherichia coli cells by chicken egg white lysozyme were performed. It was found that the ionic strength has a dual effect onto the system. On the one hand, the desorption constant of the enzyme increases with the increase of the solution ionic strength, which results in a better enzyme performance. On the other hand, due to the higher osmosis, the cell lysis rate decreases with the increasing of ionic strength of the system. It was found that pH 8.6 and 30mM NaCl are optimal conditions for lysis of E. coli cells by lysozyme.
Ex vivo expanded peripheral blood progenitor cells (PBPC) have been shown to provide rapid neutrophil engraftment, and in some patients, to eliminate neutropenia after transplantation to support high-dose chemotherapy. However, the effect of expansion culture on stem cell content and potential loss of stem cells caused by induction of differentiation remains a concern. We have transplanted 21 patients with breast cancer with expanded autologous PBPC, with 11 patients receiving expanded PBPC as their sole hematopoietic cell source. In these studies, the CD34+ cells were selected and cultured for 10 days in defined media containing 100 ng/mL each of recombinant human stem cell factor (rhSCF), recombinant human granulocyte colony stimulating factor (rhG-CSF), and recombinant human megakaryocy...
A laser beam apparatus and method for analyzing, inter alia, the current versus voltage curve at the point of illumination on a solar cell and the open circuit voltage of a solar cell. The apparatus incorporates a lock-in amplifier, and a laser beam light chopper which permits the measurement of the AC current of the solar cell at an applied DC voltage at the position on the solar cell where the cell is illuminated and a feedback scheme which permits the direct scanning measurements of the open circuit voltage. The accuracy of the measurement is a function of the intensity and wavelength of the laser light with respect to the intensity and wavelength distribution of sunlight and the percentage the dark current is at the open circuit voltage to the short circuit current of the solar cell.
We report for the first time a relationship between the Tpl-2/cot oncogene and Mouse Mammary Tumor Virus (MMTV) associated transformation of mammary gland cells. A sub-genomic library generated from a primary mammary gland tumor yielded a novel MMTV integration site which disrupted the Tpl-2/cot proto-oncogene between exons 7 and 8. Comparison of a cell line derived from normal mammary gland (comma-D) and a cell line established from an MMTV induced mammary tumor (GR) demonstrated similar rearrangements within Tpl-2/cot for the GR cells but not in the comma-D cells. These rearrangements in the cell line were accompanied by an increase in the level of Tpl-2/cot specific mRNA. This data suggests that Tpl-2/cot expression may be important in epithelial cell transformation or tumor progression. PMID:8934549
Abstract Human mesenchymal stem cells (hMSCs) may be used for therapeutic applications. Culture conditions such as the serum source may impact on cell quality and the onset of replicative senescence. We have examined the effect of culturing hMSCs in autologous serum (AS) versus fetal bovine serum (FBS) on factors involved in in vitro replicative senescence. hMSCs from four donors were cultured in 10% FBS or 10% AS until they reached senescence. Cells were harvested at early passage and near senescence to study factors known to be involved in cellular senescence. The number of population doublings till senescence was similar for cells cultured in FBS, but varied greatly for hMSCs cultured in AS. FBS cells accumulated in S phase of cell cycle. This could not be explained by increased express...
Heart cells from the clam Ruditapes decussatus were routinely cultured with a high level of reproducibility in sea water based medium. Three cell types attached to the plastic after 2?days and could be maintained in vitro for at least 1?month: epithelial-like cells, round cells and fibroblastic cells. Fibroblastic cells were identified as functional cardiomyocytes due to their spontaneous beating, their ultrastructural characteristics and their reactivity with antibodies against sarcomeric ?-actinin, sarcomeric tropomyosin, myosin and troponin T-C. Patch clamp measurements allowed the identification of ionic currents characteristic of cardiomyocytes: a delayed potassium current (I K?slow) strongly suppressed (95%) by tetraethylammonium (1?mM), a fast inactivating potassium current (I K?fas...
Human pluripotent stem cells hold promising potential in many therapeutics applications including regenerative medicine and drug discovery. Over the past three decades, embryonic stem cell research has illustrated that embryonic stem cells possess two important and distinct properties: the ability to continuously self-renew and the ability to differentiate into all specialized cell types. In this article, we will discuss the continuing evolution of human pluripotent stem cell culture by examining requirements needed for the maintenance of self-renewal in vitro. We will also elaborate on the future direction of the field toward generating a robust and completely defined culture system, which has brought forth collaborations amongst biologists and engineers. As human pluripotent stem cell re...
Pro-inflammatory cytokines may directly influence the viability and metabolic function of colonic epithelial cells (CEC) as an early event in the development of inflammatory bowel disease. We report here that TNF-alpha+IFN-gamma induced a synergistic, concentration-dependent decline in butyrate oxidation, an essential energy supply, in HT-29 and DLD-1 cells. TNF-alpha+IFN-gamma induced a parallel profound decline in cell viability in HT-29 cells, but not in DLD-1 cells, where impairment of butyrate oxidation seemed to precede later occurrence of cell damage. TNF-alpha+INF-gamma induced CEC damage was independent on NO formation and involved the IFN-gamma signalling pathway as well as induction of apoptosis. If cytokines have similar effects in vivo, these may lead to energy deficiency and thus contribute to CEC damage and disturbance of the epithelial integrity.
Gold-coated iron nanoparticles (NPs) selectively and significantly (P <0.0001) inhibit proliferation of oral- and colorectal-cancer cells in vitro at doses as low as 5 mg/mL, but have little adverse effect on normal healthy control cells. The particle treatment caused delay in cell-cycle progression, especially in the S-phase. There was no significant difference in the NP uptake between cancer and control cells, and cytotoxicity resulted primarily from the iron core, before oxidation, rather than from the Fe ions released from the core. In contrast with magnetic NPs that usually serve as drug carriers, diagnostic probes or hyperthermia media, the iron, before oxidation, in the NPs selectively suppressed cancer cell growth and left healthy control cells unaffected in vitro and in vivo. This...
Colorectal cancer is the second most common cause of cancer death in the world and about half of the patients with colorectal cancer require adjuvant therapy after surgical resection. Therefore, the eradication of cancer cells via chemotherapy constitutes a viable approach to treating patients with colorectal cancer. In this study, the effects of bufalin isolated from a traditional Chinese medicine were evaluated and characterized in HT-29 and Caco-2 human colon cancer cells. Contrary to its well-documented apoptosis-promoting activity in other cancer cells, bufalin did not cause caspase-dependent cell death in colon cancer cells, as indicated by the absence of significant early apoptosis as well as poly(ADP-ribose) polymerase and caspase-3 cleavage. Instead, bufalin activated an autophagy...
A case (female, 39?years of) of thyroid-like nasopharyngeal low-grade papillary adenocarcinoma with a significant spindle cell component is presented. The tumor was located on the posterior nasal septum. The spindle cells displayed nuclear features very much similar to the epithelial component and the two cell types merged imperceptibly. Immunohistochemically, the neoplastic cells (including the spindle cell component) were strongly and diffusely positive for TTF-1, cytokeratins (AE1-3), cytokeratin 19 and vimentin. C-kit immunohistochemistry showed diffuse mild to moderate membranous positivity with focal areas displaying moderate to strong immunoreactivity. EMA was strongly positive in the epithelial component with membranous and cytoplasmic reactivity whereas the spindle cell component ...
The Interim Examination and Maintenance (IEM) Cell is located within the Fast Flux Test Facility (FFTF) Reactor Containment Building. This cell is a complex vertical hot cell whose purpose is to process reactor experiments and to perform maintenance on reactor and refueling components. Because access to this very complex cell is limited, a mock-up called the IEM Training Facility (IEMTF) has been developed. The IEMTF provides the IEM cell with many valuable benefits. Four of these benefits are: (1) development of alternate processing methods; (2) hands-on evaluation of equipment problems; (3) a ready source of verified parts, and (4) training facilities for IEM Cell technicians.
The influence of low-frequency electromagnetic field irradiating by high-voltage transmission lines on signal transduction of cell in spleen cells of the rates have been studied by molecular-biology techniques. The spleen cells are extracted from skilled rates, which are exposed in the electromagnetic field of high-voltage transmission lines with 4000 V/m and 0.09-0.1 G about 400 days. The quantity or level of phosphorylation of signal transducer and activator of transcription (STAT3) in JAK-STAT signal transduction pathway of spleen cells, which are stimulated and unstimulated by IL-2, respectively, are detected by the immunoblotting and immunobiochemistry. The results show that the expression of phospho-STAT3 in spleen cell stimulated by IL-2 differ not from that in the unstimulated cell. The former is significantly large than the latter. This shows that ...
High-quality solar cells have been fabricated by utilizing localized argon-ion laser decomposition of silver neodecanoate spun onto diffused silicon substrates and subsequent electroplating. Early adhesion problems during electroplating have been carefully studied and finally solved using a novel coating procedure. The laser-metallized solar cells have been characterized using lighted and dark current-voltage measurements and compared with baseline cells metallized using standard photolithographic procedures. Non-AR-coated cell efficiencies ranging from 10 to over 11% have been obtained for the laser-metallized cells, comparable with the best baseline cells. The laser-metallized cells have 30 to 40% lower series resistance than the unsintered baseline cells, indicating that in-situ sintering takes place during laser ...
Reference is made to Cheng and Leblond (Amer. J. Anat.; 141:537 (1974)) who used tritiated thymidine to kill cells synthesising DNA in the crypts of the small intestine. Amongst their findings was that very low doses caused measurable cell killing and that the killing was not random throughout the crypt but occurred selectively at the crypt base where stem cells are presumably located. It is here reported that the presence of hypersensitive cells at the base of the crypts can be demonstrated after whole-body X- or gamma-irradiation, and the time sequence for the production and loss of the killed cells is described together with their dose-response relationship. The studies were conducted on mice. The data were expressed as surviving rather than killed cells, and it was established that the crypt are amongst the most sensitive of mammalian ...
In culture migrating and interacting amoeboid cells can form nematic liquid crystal phases. A polar nematic liquid crystal is formed if the interaction has a polar symmetry. One type of white blood cells (granulocytes) form clusters where the cells are oriented towards the center. The core of such an orientational defect (disclination) is either a granulocyte forced to be in an isotropic state or another cell type like a monocyte. An apolar nematic liquid crystal is formed if the interaction has an apolar symmetry. Different cell types like human melanocytes (=pigment cells of the skin), human fibroblasts (=connective tissue cells), human osteoblasts (=bone cells), human adipocytes (= fat cells) etc., form an apolar nematic liquid crystal. The orientational elastic energy is derived and the ...
Abstract Purpose: To describe the pattern of expression of the cyclin-dependent kinase inhibitors (CDKIs) p16, p21 and p27, and the cell cycle in SRA 01/04 cells relative to contact inhibition. Methods: SRA 01/04 cells were grown to overconfluence under normal conditions. At various phases of the cell growth, cells were assayed by flow cytometry and Western blotting for the expression of CDKIs. Results: Expression of p16 was detected from early logarithmic growth to stationary phases, during which the number of cells in G0/G1 increased from 46 to 69%. Expression of p21 was detected only during the overgrowth phase, when 60% of the cells were in G0/G1. Expression of p27 was not observed in SRA 01/04 cells. Conclusions: p16 expression was likely mediated by G0/G1 arrest to induce contact inh...
A conceptual design of an advanced sodium/sulfur cell for US electric-van applications has been completed. The important design factors included specific physical and electrical requirements, service life, manufacturability, thermal management, and safety. The capacity of this cell is approximately the same as that for the ``PB`` cell being developed by Silent Power Limited (10 Ah). The new cell offers a 50% improvement in energy capacity and nearly a 100% improvement in peak power over the existing PB cells. A battery constructed with such cells would significantly exceed the USABC`s mid-term performance specifications. In addition, a similar cell and battery design effort was completed for an advanced passenger car application. A battery using the van cell would have nearly 3 times the energy compared to lead-acid ...
The GEOFLOW I experiment has been successfully performed on the International Space Sta-tion (ISS) in 2008 in the Columbus module in order to study the stability, pattern formation and transition to turbulence in a viscous incompressible fluid layer enclosed in two concentric co-rotating spheres subject to a radial temperature gradient and a radial volumetric force field. The objective of the study is the experimental investigation of large scale astrophysical and geophysical phenomena in spherical geometry stipulated by rotation, thermal convections and radial gravity fields. These systems include earth outer core or mantle convection, differen-tial rotation effects in the sun, atmosphere of gas planets as well as a variety of engineering applications. The GEOFLOW I experimental instrument consists of an experiment insert for operation in the Fluid Science Laboratory, which is part of the Columbus Module of the ISS. It was ...
A review is given of the state-of-the-art of single and polycrystalline solar cells, which includes a short theoretical review, laboratory achievements, and production methods. The Si single and polycrystalline cell and the amorphous Si cell are described, including material preparation, crystal and sheet growth, and cell and panel production. Promising second generation thin film solar cells including GaAs, CdS(CuInSe/sub 2/), and CdTe are briefly described. Economical aspects are discussed.
The possibility of using lead and lead-bismuth mixed oxides as positive active materials in organic electrolyte lithium cells with a working voltage similar to those of silver zinc cells has been considered. Button cells of SR 44 size have been developed as a test vehicle and studied under various conditions of discharge rate and storage. This paper describes the performance characteristics obtained under these conditions and suggests in conclusion the possible replacement of silver zinc cells by such systems for a large range of low-rate applications on the basis of cost effectiveness.
Scientists at JPL have developed chemical and biological techniques using microspheres filled with drugs, electron-opaque metals, or radioactive, fluorescent, magnetic or electrically charged materials to label specific groups of cells. Synthetic polymeric microspheres are coupled with specific antibodies to form reagents called immunomicrospheres, which can seek out and attach themselves to any specific group of cells. These cell-labeling techniques, therefore, open new avenues not only to the basic study of cells but also to the diagnosis and treatment of many diseases, including cancer.
The combination of wood gasification and high temperature fuel cells like solid oxide fuel cells (SOFC) is an interesting approach to achieve high electrical efficiencies (40%) in small scale combined heat and power plants. This combination is called 'Biomass - Integrated Gasification Fuel Cell System' (B-IGFC). The main challenge is the adjustment of the three main components gasification, gas cleaning and fuel cell. In this technology, the first proof of principle by combining a gasifier with a SOFC in a laboratory scale for more than 100 hours was achieved. During this period, no deactivation of the system was found. (author)
The analgesic, dipyrone (1,phenyl-2,3-dimethyl-5-pyrazolone-4-methylamino methane sulphonate sodium), at 20 mM concentration, inhibited the rejoining of single-strand scissions in DNA of Escherichia coli B/r cells induced by 20 krad gamma-radiation. The chemical altered the cell membrane structure as evidenced from the uptake of acriflavin, the efflux of potassium ions from the bacterial cells and the inhibition of alkaline phosphatase-a cell membrane associated enzyme. (author). 18 refs., 6 figures.
The analgesic, dipyrone (1,phenyl-2,3-dimethyl-5-pyrazolone-4-methylamino methane sulphonate sodium), at 20 mM concentration, inhibited the rejoining of single-strand scissions in DNA of Escherichia coli B/r cells induced by 20 krad gamma-radiation. The chemical altered the cell membrane structure as evidenced from the uptake of acriflavin, the efflux of potassium ions from the bacterial cells and the inhibition of alkaline phosphatase-a cell membrane associated enzyme. (author).
Models of the human airways have played a major role in evaluating the health effects of inhaled radionuclides. While models such as those of Weibel (1963) provide data necessary for characterizing deposition of aerosol, they have not characterized the cells at risks in the airspaces. Given the advancements in techniques and study of cell cultures exposed to ionizing radiation there is a need to extrapolate between the simple structures of cell culture systems and the complex architecture of the human airways. The preliminary data in this paper provide a complete characterization of the size and number of cells in the airways and represents a significant advance in our study of the health consequences of exposure to inhaled radionuclides. 26 refs., 2 figs., 4 tabs.
Cell voltage monitoring (CVM) systems are essential for the operation of fuel cell stacks and some battery systems, in the field as well as in the laboratory, because they allow the diagnosis and correction of problems that would otherwise go unnoticed and cause impaired performance or even permanent damage. A robust, safe, and low-cost design for a CVM unit is presented, using electromechanical relays as multiplexing switches. Some examples from the application of the unit on the University of Delaware's fuel cell battery hybrid buses are presented, including its use in automatically correcting anode flooding and diagnosing air channel blockage. (author)
The radio, optical, x-ray and gamma-ray nebulae that surround many pulsars are thought to arise from synchrotron and inverse Compton emission. The energy powering this emission as well as the magnetic fields and relativistic particles are supplied by a 'wind' driven by the central object. The inner parts of the wind can be described using the equations of MHD, but these break down in the outer parts, when the density of charge carriers drops below a critical value. This paper reviews the wave properties of the inner part (striped wind), and uses a relativistic two-fluid model (cold electrons and positrons) to re-examine the nonlinear electromagnetic modes that propagate in the outer parts. It is shown that in a radial wind, two solutions exist for circularly polarized electromagnetic modes. At large distances one of them turns into a freely expanding flow containing a vacuum wave, whereas the other decelerates, corresponding to a confined flow.
Using an expanded nuclear data base, the transmutation of PCA, AMCR33 (a reduced activation austenitic steel), HT-9, Rafer2 (a reduced activation ferritic steel), V-15%Cr-5%Ti alloy, and SiAlON (a ceramic) were calculated for two positions in the Fast Flux Test Facility (FFTF), three positions in the High Flux Isotope Reactor (HFIR), and the first wall position of both the STARFIRE and MARS conceptual fusion reactors. The peripheral test (PTP) position, and to a lesser extent the radial beryllium (RB) position, of HFIR show significant transmutations which are often in the opposite direction to the transmutations in the fusion conceptual designs. The positions in FFTF, as well as the hafnium covered location in the HFIR RB position show relative minor transmutations.
Measurement results of total interaction cross sections averaged by the spectrum of ultracold neutrons (UCN) within the rate range from 3.2 to 5.7 m/s at the temperatures of 80 and 300 K for the following gases: hydrogen, parahydrogen, helium-4, nitrogen, neon, argon, xenon are presented. The experiment has been conducted conducted in the facility for UCN extraction, mounted in the radial channel of the WWR-K reactor. Experimental dependences of UCN counting rate on pressure of the investigated gases in the chamber varying from 0 to 1.5x10/sup 3/ torr are presented graphically. The measured total cross sections mainly satisfactorily agree with calculations, divergences are observed only for hydrogen and xenon.
A simple tube-in-tube heat exchanger system for thermal energy storage employing stearic acid as PCM has been investigated. The performance and heat transfer characteristics of such a system were studied. Phase transition temperature range and times were measured and the speed of the phase transition front was computed. The melting front was found to move in the radial direction inward as well as in the axial direction from the top toward the bottom of the phase change material PCM tube. The speed of the melting front is enhanced by a convection heat transfer mechanism in the melted PCM. The heat transfer rate and, consequently, phase transition time can be altered by changing the water inlet temperature to the heat exchanger. In addition, a faster phase transition is realized by placing the heat exchanger in a horizontal position rather than a vertical one. (Author)
The effect of burn-up on the thermal conductivity of homogeneous SBR MOX fuel is investigated and compared with standard UO_2 LWR fuel. New thermal diffusivity results obtained on SBR MOX fuel with a pellet burn-up of 35 MWd/kgHM are reported. The thermal diffusivity measurements were carried out at three radial positions using a shielded 'laser-flash' device and show that the thermal diffusivity increases from the pellet periphery to the centre. The fuel thermal conductivity was found to be in the same range as for UO_2 of similar burn-up. The annealing behaviour was characterized in order to identify the degradation due to the out-of-pile auto-irradiation.
The spatial distribution of argon clusters in gas jet is tested using the Rayleigh scattering method. A pulsed laser is used to acquire the whole evolution of the cluster inside one event. The measured results at a fixed axial position show that the argon clusters grow in less than one millisecond after the nozzle is opened and the cluster size keeps constant during the whole open period of 20 ms. Further results show that the scattering signal along the radial direction is almost Gaussian-distributed and the full width half maximum (FWHM) increases almost linearly when the distance from nozzle increases. The scattering signal along the axial direction is Landau-distributed and the area near the nozzle is most effective for laser cluster interaction. (authors)
Despite advances in polymer and drug technology, the underlying stent platform remains a key determinant of clinical outcome. A clear understanding of stent design and the differences between various stent platforms are of increasing importance for the interventional cardiologist. Reduction in stent strut thickness has been associated with improved stent deliverability, improved procedural outcome, and lower rates of subsequent restenosis. Newer-generation 316L-SS stent designs have enabled reduced strut thickness while retaining radial strength and minimizing recoil, but with significant loss of radiopacity, leading to reduced visibility. Cobalt chromium alloys have enabled a reduction in stent strut thickness to around 80?90 mm while retaining modest radiopacity, but due to higher elasti...
The mixture of 65 mol% capric acid and 35 mol% lauric acid (C-L acid) is a potential latent heat storage material. However, its melting temperature of 18.0 {sup o}C is quite high for low-temperature thermal energy storage. Addition of pentadecane, with a melting point of 9.9 {sup o}C, is proposed. The thermal characteristics of the combination of the C-L acid with pentadecane (CL:P) in different volume ratio are investigated employing the DSC analysis. The actual thermal performance of each CL:P combination is further determined from their radial and axial temperature distribution employing a fabricated thermal storage capsule. The 90:10 CL:P combination manifests an improvement in the melting characteristic of the C-L acid.(author)
Peculiar velocities induce apparent line of sight displacements of galaxies in redshift space, distorting the pattern of clustering in the radial versus transverse directions. On large scales, the amplitude of the distortion yields a measure of the dimensionless linear growth rate \\ff of fluctuations, which is related to the cosmological density \\Omega and the linear bias factor b in linearly biassed standard cosmology by \\ff \\approx \\Omega^{0.6} /b. To make the maximum statistical use of the data in a wide angle redshift survey, and for the greatest accuracy, the spherical character of the distortion needs to be treated properly, rather than in the simpler plane parallel approximation. In the linear regime, the redshift space correlation function is described by a spherical distortion operator acting on the true correlation function. It is pointed out here that there exists an operator, which is essentially the logarithmic derivative with respect to pair ...
We investigate the existence of time-periodic solutions of the Dirac equation in the Kerr-Newman background metric. To this end, the solutions are expanded in a Fourier series with respect to the time variable $t$ and the Chandrasekhar separation ansatz is applied so that the question of existence of a time-periodic solution is reduced to the solvability of a certain coupled system of ordinary differential equations. First, we prove the already known result that there are no time-periodic solutions in the non-extreme case. Then it is shown that in the extreme case for fixed black hole data there is a sequence of particle masses $(m_N)_{N\\in\\mathbb N}$ for which a time-periodic solution of the Dirac equation does exist. The period of the solution depends only on the data of the black hole described by the Kerr-Newman metric.
This paper describes in an apparatus for absorbing a beam of concentrated solar energy and which includes a cavity receiver with an inlet for transmission thereinto of solar radiation, a protective apertured shield means about the inlet. It comprises: rigid support means fixed to the periphery of the inlet and projecting radially inwardly therefrom to define a generally central aperture area through which the solar radiation can pass into the cavity receiver; and non-structural blanket means spread over the rigid support means between the periphery of the inlet and the aperture area, the material having a high temperature capability and providing for infra-red radiation insulation, while remaining relatively cool when subjected to solar radiation.
Two quantities play a central role in that part of nonlinear optics which deals with the effects of a finite momentum spread in a particle beam: the orbit position whose derivative with respect to momentum is called 'orbit dispersion' and the betatron wave number whose derivative WRT momentum is the 'chromaticity'. The orbit dispersion varies with the azimuth and is essentially horizontal in a machine with a horizontal symmetry plane; parasitic radial fields induce a vertical component. The chromaticity is a scalar quantity related to the integral of the focusing strength, over one turn of the machine; it is defined for the horizontal and vertical planes. After recalling the general motion equation in the horizontal plane, the orbit dispersion and the chromaticity will be treated. Closed formulae are given for lumped elements and special emphasis is put on dipoles with a high deflection angle. (8 refs).
In this article, the ability of artificial neural networks in prediction of separation in steady two dimensional boundary layer flows is studied. Data for network training is extracted from numerical solution of an ODE obtained from Von Karman integral equation with approximate one parameter Pohlhousen velocity profile. As an appropriate neural network, a two layer radial basis generalized regression artificial neural network is used. The results shows good agreements between the overall behavior of the flow fields predicted by the artificial neural network and the actual flow fields for some cases. The method easily can be extended to unsteady separation and turbulent as well as compressible boundary layer flows. (author)
In this article, the ability of artificial neural networks in prediction of separation in steady two dimensional boundary layer flows is studied. Data for network training is extracted from numerical solution of an ODE obtained from Von Karman integral equation with approximate one parameter Pohlhousen velocity profile. As an appropriate neural network, a two layer radial basis generalized regression artificial neural network is used. The results shows good agreements between the overall behavior of the flow fields predicted by the artificial neural network and the actual flow fields for some cases. The method easily can be extended to unsteady separation and turbulent as well as compressible boundary layer flows. (author)
A steadily increasing part of comminution is nowadays carried out by tube ball mills. Our investigations are a first step to a possible tuning of material distribution with mechanical stress characteristic of the grinding media charge, that is essential for a high efficiency of grinding. A BOND mill filled with porcelain balls as grinding media and labelled corundum (Au-198) as grinding material was used to measure the distribution of material over the cross-section. The evaluation was made by linear interpolation between all combinations of adjacent measuring points to calculate all coordinates with equal intensity for each selected level of activity. Two plottings showing the dependence of material distribution on the rotating speed are presented. (author).
A method for systematically including topological degrees of freedom in perturbation theory is developed. This is not bound by the restrictions of semi-classical techniques. The Yang-Mills theory in three Euclidean dimensions is considered here. A well-defined separation of the topological and the ``spin wave'' degrees of freedom is obtained, motivated by a singular gauge. This has ``photons'' distorting the spherically symmetric magnetic fields of Dirac monopoles, and massless charged vector bosons ``W'' scattering off the latter. It is explicitly shown that the Dirac string does not contribute. The mode of the charged vector bosons with total angular momentum J=0 provides precisely the core to give a finite energy to the monopole. The radial equation for W is remarkably simplified and only two polarization states survive exactly for the anomalous magnetic moment required by the Yang-Mills interaction.
A 206-size hybrid (ceramic/steel) cylindrical roller bearing was tested in MIL-L-23699 C oil at several speeds and loads. Heat-generation data was collected and subsequently correlated with bearing-analysis software. Bearing-cage slip data was also collected at various oil-flow rates, oil temperatures, and with both MIL-L-7808 J and MIL-L-23699 C oils. The hybrid bearing was tested in MIL-L-23699 C oil for for 25 hours at 2220 N radial load and 1.08 MDN shaft speed. The hybrid bearing technology demonstrated in the report is applicable to the Integrated High Performance Turbine Engine Technology Initiative. 15 refs.
The validity is given to the newly proposed two weighting {delta}f scheme (Wang et al., Research Report of National Institute for Fusion Science NIFS-588, 1999) for collisional or neoclassical transport calculations, which can solve the drift kinetic equation taking account of effects of steep plasma gradients, large radial electric field, finite banana width, and the non-standard orbit topology near the axis. The marker density functions in weight equations are successively solved by using the idea of {delta}f method and a hierarchy of equations for weight and marker density functions is obtained. These hierarchy equations are solved by choosing an appropriate source function for each marker density. Thus the validity of the two weighting {delta}f scheme is mathematically proved. (author)
Supernova explosions within wind-driven bubbles are studied with 2D hydrodynamical calculations. Two different density distributions for the ejecta are considered: (i) a smooth, unfragmented power-law stratification, and (ii) a fragmented distribution. As in 1D models, the presence of the shell of interstellar swept-up matter causes the rapid evolution of the remnant to the radiative phase. The main 2D effects, for both fragmented and unfragmented ejecta, include: (i) substantial chaotic deviations from a purely radial flow in the remnant interior, (ii) efficient turbulent mixing between the ejecta and the shocked wind, resulting in homogenization of the former wind cavity, and (iii) severe distortion of the wind-driven shell by cooling and Rayleigh-Taylor instabilities. (author).
In a new series of modulated electron cyclotron heating (MECH) on RTP the MECH power was deposited either on-axis or off-axis in plasmas with different values of the plasma current (I{sub p}). Besides confirming all previous MECH results on RTP, the new data can be simulated by assuming a radial profile of the incremental diffusivity ({chi}{sup inc}) that is constant ({chi}{sup inc} < 1 m{sup 2}/s) inside the sawtooth region, makes a sharp step near the inversion radius, and has an offset parabolic profile elsewhere with a value of {chi}{sup inc} {approx} 6 m{sup 2}/s at r/a {approx} 0.6. No significant dependence of {chi}{sup inc} on q{sub a} is observed apart from the position of the transition from low to high {chi}{sup inc}. (author) 5 refs., 4 figs.
The problem of a spin 1 charged particle with electromagnetic polarizability, obeying a generalized 15-component quantum mechanical equation, is investigated in presence of the external Coulomb potential. With the use of the Wigner's functions techniques, separation of variables in the spherical tetrad basis is done and the 15-component radial system is given. It is shown that there exists a class of quantum states for which the additional characteristics, polarizability, does not manifest itself anyhow; at this the energy spectrum of the system coincides with the known spectrum of the scalar particle. For j=0 states, a 2-order differential equation is derived, it contains an additional potential term 1/r^{4}. In analogous approach wave functions the generalized particle are examined in presence of external Dirac monopole field. It is shown that there exists one special state with minimal conserved quantum number j_{min}. It this solution, first, the polarizability ...
Modern tubular type pumps commonly have lubricated radial bearings which require no compressed water supply and reduce the servicing requirements. Problems that may possibly result from entrained sand in the pumped fluid were solved with the development of ceramic Residur {sup trademark} bearngs in the early eighties. (orig.) [German] In zunehmendem Masse werden Rohrgehaeusepumpen mit foerdermediumgeschmierten Radiallagern ausgestattet, da dies z.B. neben dem Wegfall einer ansonsten notwendigen Druckwasserversorgung auch einen deutlichen reduzierten Wartungsaufwand nach sich zieht. Den Problemen durch eine moegliche Sandbeladung des Foerdermedium wurde bereits durch die Entwicklung der keramischen Residur {sup trademark} -Lager Anfang der 80er Jahre Rechnung getragen. (orig.)
The Lorentz and coordinate covariant calculus of spinors in Riemannian spacetime, which is the mathematical model for the description of the quantum mechanics of elementary particles with spin interacting with the classical gravitation field, is explored. The Dirac equation describing the interaction of neutrinos with the gravitational fields of the Robertson-Walker cosmological world models is separated, and the spectrum of eigenfunctions and eigenvalues for particular choices of the set of quantum numbers is given explicitly for the k = 0 and k = +1 models, although only the radial equations determining the final quantum number are given for the k = -1 model. The mathematical theory of the motion of a perfect fluid whose elements interact via long-range neutrino-exchange forces, as well as gravitationally, is developed. The formalism for calculating, by calculating the Bogoliubov transformation of the Fock space operators that instantaneously diagonalize their ...
Because the state of a free-floating space robot model is uncertain and sudden changes in the model parameters might undermine the stability of the system, this paper proposes a control strategy based on a variable structure neural integrated controller. This scheme does not need a precise space robot model, making use of the radial basis function neural network ability approach to learn about an uncertain model. The network weights are adjusted online in real-time. During the early period of the control phase and parameter changes, the variable structure controller compensates for the uncertain model which the neural network could not learn well. It also creates global asymptotic stability for the whole closed-loop system. Simulation results show that the controller can handle bad changea...
Water flow experiments were conducted on natural circulation decay heat removal with an electrically heated 91-rod bundle. Experimental results were compared with analytical predictions to provide thermal hydraulic characteristics for LMFBR Fuel assemblies under a low flow, typical of the natural circulation regime. The results revealed that, at low flow rate region (Re<1,200), axial friction loss in a heated bundle increases with buoyancy effect. The radial temperature profile provides some insight regarding the concept that coolant redistribution would occur. COBRA-V-I predictions are successfully proved validity in comparison with experimental results.
All-atom molecular dynamics simulations were used to study the morphology of polymer/inorganic composite particles prepared by heterocoagulation. The results were also compared to those of our previous study of the preparation of TiO2/poly(acrylic acid-co-methyl methacrylate) and Fe3O4/polystyrene composite particles. In the simulation system, polymer or inorganic particles were simulated by surface-charge-modified C60 or Na atoms. Through a combination of analysis of the radial distribution functions of charged atoms and snapshots of the equilibrated structure, three kinds of particle distributions were observed under different conditions. When the polymer and inorganic particles had opposite surface charges and their sizes were very different, the composite morphology showed a core-shell...
O.K. Andersen has recently introduced a linear augmented plane wave method (LAPW) for the calculation of electronic structure that was shown to be computationally fast. A more general formulation of an LAPW method is presented here. It makes use of a freely disposable number of eigenfunctions of the radial Schroedinger equation. These eigenfunctions can be selected in a self-consistent way. The present formulation also results in a computationally fast method. It is shown that Andersen's LAPW is obtained in a special limit from the present formulation. Self-consistent test calculations for copper show the present method to be remarkably accurate. As an application, scalar-relativistic self-consistent calculations are presented for the band structure of FCC lanthanum. (author).
We have analyzed data obtained with the Deep River neutron monitor and the underground vertical muon telescope at Embudo for the period 1965--79. Our data in conjunction with other published data show that for 1957--70 the diurnal anisotropy is unidirectional; with direction along 18 hour LT (east-west). During 1971--79, the diurnal anisotropy consists of two components. One is in east-west direction and the other is the radial component, with direction along 12 hour LT. The latter attains a maximum amplitude in 1976. We find no evidence for the existence of the twenty year wave in the diurnal anisotropy of cosmic rays. copyright American Geophysical Union 1988
A new test methodology is described which allows access to loading rates that lie between split Hopkinson bar and shock-loading techniques. Gas gun experiments combined with velocity interferometry techniques have been used to experimentally determine the intermediate strain-rate loading behavior of Coors AD995 alumina and Cercom silicon-carbide rods. Graded-density materials have been used as impactors; thereby eliminating the tension states generated by the radial stress components during the loading phase. Results of these experiments demonstrate that the time-dependent stress pulse generated during impact allows an efficient transition from the initial uniaxial strain loading to a uniaxial stress state as the stress pulse propagates through the rod. This allows access to intermediate loading rates over 5 x 10{sup 3}/s to a few times 10{sup 4}/s.
Engineering details of a high voltage driven corona-plasma ozone generator are described. The plasma diode of generator has coaxial cylindrical geometry with cathode located inside anode. Cathode is made of a large number of radial gas nozzles arranged on central tubular mast which admits oxygen gas. The sharp endings of the nozzles along with a set of corona rings create the high electric field at the cathode required for formation of dense corona plume responsible for O_3 evolution. A model of coronal plasma generation and ozone production is presented. The plasma formation is strongly dependent on the electric field and temperature in side diode where a high electron density in a low temperature negative corona is suited for high ozone yields. These are established by suitable regulation of A-K gap, voltage, oxygen pressure, and cathode-nozzle population.
The characteristics of the local magnetic shear, a quantity associated with high-mode-number ballooning mode stability, are considered in heliotron/torsatron devices that have a large Shafranov shift. The local magnetic shear is shown to vanish even in the stellarator-like region in which the global magnetic shear is positive. The reason for this is that the degree of the local compression of the poloidal magnetic field on the outer side of the torus, which maintains the toroidal force balance, is reduced in the stellarator-like region of global magnetic shear because the global rotational transform in heliotron/torsatron systems is a radially increasing function. This vanishing of the local magnetic shear is a universal property in heliotron/torsatron systems with a large Shafranov shift since it results from toroidal force balance in the stellarator-like global shear regime that is inherent to such systems.
In the emerging restructured power system, the congestion management (CM) has become extremely important in order to ensure the security and reliability of the system. In addition to this, lack of CM can impose a hindrance in electricity trading. This paper presents a novel, growing radial basis function neural network (GRBFNN)-based approach for CM. For achieving CM, Nodal congestion price (NCP) forecasting is performed in real time competitive power market. NCP forecasting is an effective way of price-based preventive CM as it directly indicates the presence as well as the severity of the congestion in the system. In present paper, GRBFNN has been developed for NCP forecasting dividing the whole power system into various congestion zones. An unsupervised learning vector quantization (VQ)...
The dynamic response of cylindrical and ring-shaped YBaCuO bulk parts to pulsed magnetic fields is calculated by using small sets of finite elements. Some comparisons with experimental results are provided, and they give confidence in the modelling of the superconducting properties. Transient magnetizations as a function of time and space as well as shapes and absolute values of trapped magnetic flux profiles are presented. The influence of the sample geometry is investigated for different millisecond pulsed magnetization processes. Results are reported for different radial thicknesses and heights, different pulse durations, peak magnetic fields and pulse sequences with and without stepwise cooling. Comparisons concerning the achievable trapped magnetic field and flux are made, and implications for the use of high-temperature superconductor bulk parts as cryo-permanent magnets in potential applications like electric machinery are discussed.
The controlled growth of nanowires (NWs) with dimensions comparable to the Fermi wavelengths of the charge carriers allows fundamental investigations of quantum confinement phenomena. Here, we present studies of proximity-induced superconductivity in undoped Ge/Si core/shell NW heterostructures contacted by superconducting leads. By using a top gate electrode to modulate the carrier density in the NW, the critical supercurrent can be tuned from zero to greater than 100 nA. Furthermore, discrete sub-bands form in the NW due to confinement in the radial direction, which results in stepwise increases in the critical current as a function of gate voltage. Transport measurements on these superconductor-NW-superconductor devices reveal high-order (n = 25) resonant multiple Andreev reflections, indicating that the NW channel is smooth and the charge transport is highly coherent. The ability to create and control coherent superconducting ordered states in ...
Preparations are under way for the initial startup and testing of the Fast Flux Test Facility (FFTF). The FFTF Reactor Characterization Program is that part of the startup test plan that deals with the determination of the neutron, gamma ray and thermal hydraulic characteristics of the reactor. This program encompasses measurements and calculations of: neutron spectra, flux and fluence; gamma-ray spectra, dose and heating; fission rate distributions; capture rate distributions; other reaction rates of interest; fission product yields; and thermal hydraulic data. Measurements of these parameters will be made in the reactor core and reflectors, will extend vertically downward to the vicinity of the core support structure and upward to the top of the sodium pool, and will extend radially outward to include in-vessel fuel storage locations and the cavity between the reactor vessel and the concrete wall.
In the WWER-440 reactor the primary piping consists of six horizontal loops going radially from the pressure vessel, each loop having a horizontal steam generator. In this reactor type the relatively long primary piping with many curved sections requires special attention in order to successfully eliminate the consequences of the design basis accident. Emergency supports are located in appropriate places to restrict the movements of the pipe. Under normal conditions there is a gap of some centimeters between the pipe and a support so that in the pipe can be deformed freely under changing loads. This paper deals with those energy-absorbing structures used at the Loviisa Nuclear Power Plant for protection against impact loading. Places and circumstances where energy-absorbing structures are employed are specified. Development and design of impact absorber elements are discussed and impact tests are described. (Auth.).
Background/Purpose: Congenital esophageal stenosis (CES) is a rare malformation. Endoscopic dilations represent a therapeutic option. This study retrospectively evaluated the efficacy and safety of a conservative treatment of CES. Patients and Methods: Patients diagnosed with CES since 1980 by a barium study or endoscopy were reviewed. Endoscopic ultrasonography (Olympus UM-3R-20-MHz radial miniprobe, Olympus Corporation, Tokyo, Japan), available from 2001, allowed for the differential diagnosis of tracheobronchial remnants (TBR) and fibromuscular hypertrophy (FMH) CES. All children underwent conservative treatment by endoscopic dilations (hydrostatic and Savary). Results: Forty-seven patients (20 men) had CES. Fifteen were associated with esophageal atresia; and 8, with Down syndrome. Mea...
We have calculated the electronic structure of Eu for the bcc, hcp, and fcc crystal structures for volumes near equilibrium up to a calculated 90 GPa pressure using the augmented-plane-wave method in the local-density approximation. The frozen-core approximation was used with a semi-empirical shift of the f-states energies in the radial Schroedinger equation to move the occupied 4f valence states below the #GAMMA#_1 energy and into the core. This shift of the highly localized f-states yields the correct europium phase ordering with lattice parameters and bulk moduli in good agreement with experimental data. The calculated superconductivity properties under pressure for the bcc and hcp structures are also found to agree with and follow a T_c trend similar to recent measurement by Debessai et al.
The effect of a sawtooth crash on the radial distribution of the slowing down fusion product tritons and on beams ions, is examined with measurements of the 2.5 MeV and 14 MeV neutron emission line-integrals before and after sawtooth crashes. In deuterium discharges, the 14 MeV neutron production was wholly attributable to burnup of the 1 MeV fusion product tritons from d-d fusion. The local emissivity of 14 MeV neutrons, and hence of the profile of thermalizing tritons, is shown to be only weakly affected by crashes in the discharges studied. This is in contradiction with the apparent behaviour of injected beam ions as deduced from a study of the considerable changes in local emissivity of the 2.5 MeV neutrons. Nevertheless, the behaviour of the fusion product tritons is consistent with the scaling of the beam injected deuterium. 1 ref., 6 figs.
The effect of Kerr nonlinearity on an Airy beam is investigated by using the nonlinear Schroedinger equation. Based on the moments method, the evolution of the Airy beam width in the rms sense is analytically described. Numerical simulations indicate that the central parts of the major lobe of the Airy beam initially give rise to radial compression during propagation in a focusing medium, even though the rms beam width broadens. The partial collapse of the center parts of the major lobe of the beam appear below the threshold for a global collapse. The evolutions of the field distributions of the Airy beams are different during propagation in different Kerr media while the beams still travel along the parabolic trajectory just as the beam propagates in free space.
We have obtained radial velocities for 69 stars in the globular cluster M2 (NGC 7089). M2's rotation axis is, within sizeable uncertainties, perpendicular to the major axis determined by the flattening. The ratio of rotational to random kinetic energy agrees with that predicted from the ellipticity assuming an oblate figure and an isotropic velocity-dispersion tensor. We have fitted King-Michie models to determine M2's mass, the exponent of an assumed power-law mass function, and the anisotropy radius. The most significant sources of uncertainty in the modeling are the velocity dispersion, the distance, and the mass-luminosity relation for the cluster stars. The models favor mass functions similar to or shallower than the Salpeter initial-mass function and a moderate amount of velocity anisotropy.
Improved separation of heavier material from a dispersoid of gas and heavier material entrained therein is taught by the method of this invention which advantageously uses apparatus embodied in an inertial separator having rotary partition means comprising wall members dividing a housing into a plurality of axially-extending through passages arranged in parallel. Simultaneously with the helical transit of a moving stream of the dispersoid through the parallel arrangement of axially-extending through passages at a constant angular velocity, the heavier material is driven radially to the collecting surfaces of the rotational wall members where it is collected while the wall members are rotating at the same angular velocity as the moving stream. The plurality of wall members not only provides an increased area of collecting surfaces but the positioning of each of the wall members according to the teaching of this invention also results in a shortened time-of-flight to ...
Sulfur pollution can lead to serious problems in freshwater wetlands, including phosphorus eutrophication and sulfide toxicity. We tested the effects of anaerobic iron-rich groundwater discharge in fens, simulated by iron injection, on two characteristic species (Juncus effusus and Caltha palustris) in a sulfidic environment. Biomass production of C. palustris roots showed an optimum response to the combined addition of iron and sulfide, with highest values at intermediate concentrations of both substances. Iron deficiency apparently occurred at low iron concentrations, while at high iron concentrations, growth was decreased. For J. effusus, in contrast, no toxic effects were found of both iron and sulfide. This could be explained by larger radial oxygen loss (ROL) of J. effusus and could ...
An all-atom polarizable chloroform (CHCl{sub 3}) potential model has been developed using the classical molecular dynamics techniques. This potential is shown to reproduce reasonably well the structural, dynamical, and thermodynamic properties of bulk liquid CHCl{sub 3} at various temperatures and pressures. With this potential, we carried out computer simulations to investigate the CHCl{sub 3}-H{sub 2}O liquid/liquid interface. Detailed structural and electrical properties at the interface will be analyzed via the density profile, radial distribution functions, molecular orientation, hydrogen bonding, and the z-dependent dipole distributions. Comparison will also be made to the results of the CCl{sub 4}-H{sub 2}O liquid/liquid interface.
The homogeneity of a helium dielectric barrier discharge, working at atmospheric pressure and containing oxygen as contaminant, is assessed by mapping the spatial distribution of oxygen metastable atoms in relation to the uniformity of surface properties. Tunable diode laser absorption spectroscopy is used to monitor the time evolution of the absorption coefficient corresponding to the oxygen metastable atoms on the 35S2 level, as a function of the laser absorbing path, whereas bi-dimensional Abel transform is used to obtain local information on the space distribution of the metastable atoms in the discharge. The radial distribution of the surface properties is investigated using atomic force microscopy, contact angle measurement and X-ray photoelectron spectroscopy. The results show that ...
The (simplified) Backus? Problem (BP) consists in finding a harmonic function u on the domain exterior to the three dimensional unit sphere S, such that u tends to zero at infinity and the norm of the gradient of u takes prescribed values g on S. Except for a change of sign, the solution is not unique in general. However, there is uniqueness of solutions in the class of functions with the additional property that the radial component of the gradient of u on S is nonpositive. This is the geodetically relevant case. If a solution u with this property exists, then u is the maximal solution of the problem (and -u the minimal one). In this paper we propose a method of successive approximations to get this particular solution of BP and prove the convergence for functions g close to a constant fu...
The Cycle 8A static tests conducted in the Fast Flux Test Facility (FFTF) during 1986 have resulted in the separation of various feedback reactivity components. These feedback components, described by closed-form equations depending only on the reactor temperature field, can be regarded as database for the validation and/or calibration of feedback mechanistic models. The SASSYS safety analysis code contains the most developed feedback reactivity models and was selected for the comparison study between database and mechanistic calculations for the FFTF. Although detailed feedback models for control rod repositioning and core radial expansion/bowing exist, only the simple models were available in SASSYS at the time of this study. The results are described in this paper.
Gelatine is a reliable tissue simulant in wound ballistic experiments. The projectile penetrating the gelatine transfers energy and causes radial cracks according to the temporary cavity. Thus the crack length is a function of the energy spent in the medium. In practice the fissures are poorly contrasted for which reason an enhancement of contrast was searched. A series of six shoots with expanding bullets (9mmx19 Action-5, 9mmx19 Quick Defense 1, 5.56mmx45 Styx Action) was realized on 10% gelatine blocks at 4^oC temperature. Three blocks were marked with acryl paint on the front, three blocks were shot native. The blocks were cut in slices of 1cm thickness and optically scanned. The evaluation was performed according to Fackler's wound profile, the total crack length method and the polygo...
From self-consistent band structure calculations using the 'augmented plane wave'(APW) method, the density of states can be decomposed into local partial (according to azimuthal quantum number l) components, the l-character densities. Within the APW formalism the intensity of X-ray emission spectra is determined by radial transition probabilities and l-character densities of such valence states, which reside inside the same atomic sphere as the core vacancy and whose quantum number l differs by +-1 from the one corresponding to the core state. By taking into account lifetime broadening of the core and valence states and also the instrumental broadening the computed spectra (non-metal K-, vanadium K- and Lsub(III)-spectra) agree well with experiment. (orig.).
The facilities in the Institute for Nuclear Research at Pitesti allow the testing, handling and examination of nuclear fuel and irradiated materials. The most important facilities are the TRIGA Steady State Research and Material Test Reactor and the Post-Irradiation Examination Laboratory (PIEL). The purpose of this work is to determine by post-irradiation examination, the behavior of CANDU fuel, irradiated in 14 MW TRIGA reactor. The fuel was irradiated in power ramp conditions. The results of post-irradiation examination are: - Visual inspection and photography of the outer appearance of sheath; - Profilometry (diameter, bending, ovality) and length measuring; - Determination of axial and radial distribution of the fusion products activity by gamma scanning and tomography; - Microstructural characterization by metallographic and ceramographic analyzes; - Mechanical properties determination. The data obtained from the post-irradiation examination are used to ...
The principal objective of this study is to formulate an effective optimal fuel management strategy for the TRIGA MARK II research reactor at AERE, Savar. The core management study has been performed by utilizing four basic types of information calculated for the reactor: criticality, power peaking, neutron flux and burnup calculation. This paper presents the results of the burnup calculations for TRIGA LEU fuel elements. The fuel element burnup for approximately 20 years of operation was calculated using the TRIGAP compute code. The calculation is performed in one-dimensional radial geometry in TRIGAP. Inter-comparison of TRIGAP results with other two calculations performed by MVP-BURN and MCNP4C-ORIGEN2.1 show very good agreement. Reshuffling at 20,000MWh step provides the highest core l...
BackgroundWave reflection during the systole increases left ventricular (LV) pressure, tension-time index (TTI) and myocardial oxygen requirement. The purpose of this study was to extract that component of extra myocardial oxygen requirement that is due to early systolic wave reflection, define it as wasted effort (?Ew), and examine its relationship to LV hypertrophy (LVH).MethodsRadial artery pressure waveforms were recorded using applanation tonometry and central aortic waveforms generated in 98 patients with untreated hypertension. Aortic augmentation index (AIa), wave reflection amplitude (i.e., aortic augmented pressure (AG)) and systolic duration (ED?Tr), ejection duration (ED) and round-trip travel time of the pressure wave (Tr) were calculated from the aortic waveform, a...
We compare the metallicities of stars with radial velocity planets to the metallicity of a sample of field dwarfs. We confirm recent work indicating that the stars-with-planet sample as a whole is iron rich. However, the lowest mass stars tend to be iron poor, with several having [Fe/H]0.48) that contributes to but does not explain the mass-metallicity trend in the stars-with-planets sample. We use Monte Carlo models to show that adding an average of 6.5 Earth masses of iron to each star can explain both the mass-metallicity and the age-metallicity relations of the stars-with-planets sample. However, for at least one star, HD 38529, there is good evidence that the bulk metallicity is high. We conclude that the observed metallicities and metallicity trends are the result of the interaction of three effects; accretion of about 6 Earth masses of iron rich material, selection effects, and in some cases, high intrinsic metallicity.
A gas core fission reactor that utilizes americium in place of uranium is examined for potential utilization as a nuclear rocket for space propulsion. The isomer [sup 242m]Am with a half life of 141 years is obtained from an (n, [gamma]) capture reaction with [sup 241]Am, and has the highest known thermal fission cross section. We consider a 7500 MW reactor, whose propulsion characteristics with [sup 235]U have already been established, and re-examine it using americium. We find that the same performance can be achieved at a comparable fuel density, and a radial size reduction (of both core and moderator/reflector) of about 70%.
We analyse numerically the acoustic stop band properties of an array of orthotropic coated cylinders whose elastic parameters are deduced from a geometric transform [H. Chen, C.T. Chan, Acoustic cloaking in three dimensions using acoustic metamaterials, Appl. Phys. Lett. 91 (2007) 183518]. We find that whereas a single coated inclusion is acoustically neutral at any frequency, an array of them might display some stop bands. More precisely, an array of freely vibrating coated voids is always neutral, whereas an array of clamped coated inclusions might display a zero frequency stop band. Interestingly, an array of radially symmetric coated inclusions behaves as local Helmholtz resonators, for which the eigenfield within each cloak is obtained in closed form, leading to a frequency estimate a...
In this study, a two-stage support-vector-regression optimization model (TSOM) is developed for the planning of municipal solid waste (MSW) management in the urban districts of Beijing, China. It represents a new effort to enhance the analysis accuracy in optimizing the MSW management system through coupling the support-vector-regression (SVR) model with an interval-parameter mixed integer linear programming (IMILP). The developed TSOM can not only predict the city's future waste generation amount, but also reflect dynamic, interactive, and uncertain characteristics of the MSW management system. Four kernel functions such as linear kernel, polynomial kernel, radial basis function, and multi-layer perception kernel are chosen based on three quantitative simulation performance criteria [i.e....
The authors describe a small doubly reflecting research furnace. Its optical components, a heliostat and a concentrating array of hexagonal-in-plan-form mirrors, focus sunlight at the aperture of a cavity receiver. A perfect paraboloid of revolution would have given higher concentration ratios. But large paraboloids are difficult to make and manipulate. Small hexagons are convenient and can be close packed. Spherical mirrors centered on a sphere simplified construction and were economical. In this note they use a simple model to describe the radial distribution of the normal flux at the focus of such an array. A schematic representation of a cross section of the concentrator mirror array in a plane which includes its axis is shown.
This work addresses the problem of estimating the direction-of-arrival (DOA) of two sources using an array of sensors. This problem is mostly useful in radar applications, where we have few targets at each range bin. Super-resolution algorithms, such as maximum likelihood (ML) estimation and multiple signal classification (MUSIC), have been applied to this problem, but the former involves high computation efforts, while the later has poor estimation performance for coherent sources. In this work, we propose a DOA estimation network, named RBF-AML, which combines the approximated ML (AML) estimator and a radial basis function (RBF) neural network (NN). In the proposed RBF-AML network, the entire two dimensional DOA space is divided into multiple sectors covered by RBF experts. The AML funct...
A large acceptance, high stopping power, Bragg curve spectrometer has been developed for use in coincidence experiments with heavy ions. The electron collection fields are radial and position information is obtained from a resistive anode. The detector is 60 cm deep and operates at pressures of up to 2.5 atm of P-10 gas. It is mated to a scattering chamber which allows it to be moved out of plane during coincidence measurements. The detector design was aided by the results of computer simulations of the electron collection process in the detector, and of the signal processing in the electronics. The signals from the Bragg curve spectrometer are recorded in a waveform digitizer and the Bragg peak height, range, position and pileup rejection information are determined from software analysis of the recorded signals. Factors limiting the performance of the detector are discussed, and results obtained with the detector are presented. (orig.).
A large acceptance, high stopping power, Bragg curve spectrometer has been developed for use in coincidence experiments with heavy ions. The electron collection fields are radial and position information is obtained from a resistive anode. The detector is 60 cm deep and operates at pressures of up to 2.5 atm of P-10 gas. It is mated to a scattering chamber which allows it to be moved out of plane during coincidence measurements. The detector design was aided by the results of computer simulations of the electron collection process in the detector, and of the signal processing in the electronics. The signals from the Bragg curve spectrometer are recorded in a waveform digitizer and the Bragg peak height, range, position and pileup rejection information are determined from software analysis of the recorded signals. Factors limiting the performance of the detector are discussed, and results obtained with the detector are presented. (orig.).
The flexible, insulated, single strand cables are electrically connected with a cylindrical polar tip (PN) by means of cylindrical and conical shafts for the polar tips, which enter the faces of the divided, multiwire strand, clamped by tension half couplings. The flat ends of the polar tips being joined are positioned in two concentric mandrel bushings, an internal fixed one and an external, axially movable bushing (PV). The internal bushing is rigidly attached to the end of the left polar tip and equipped with three or four rounded, radial openings, whose diameter is determined by the external diameter of the locking device hinges (ShF) of the connecting couplings. The right polar tip is equipped with an annular channel of trapezoidal section into which the locking device hinges enter. The external movable bushing on the right side has a conical turning and on the left, a cylindrical into which the cylindrical spring which holds the movable bushing in the extreme ...