rabbit vascular smooth: Topics by WorldWideScience.org

Increased endothelial and vascular smooth muscle cell adhesion on nanostructured titanium and CoCrMo

We investigate a method for gene delivery to vascular smooth muscle cells using ultrasound triggered delivery of plasmid DNA from electrostatically coupled cationic microbubbles. Microbubbles...Full Text Available

2010-09-01

2

EFFECT OF AGE ON THE ROLE OF RHO-KINASE IN SHORT TERM PARTIAL BLADDER OUTLET OBSTRUCTION

In the body, vascular cells continuously interact with tissues that possess nanostructured surface features due to the presence of proteins (such as collagen and elastin) embedded in the vascular wall....Full Text Available

2006-03-01

3

Soluble Epoxide Hydrolase as a Therapeutic Target for Cardiovascular Diseases

ObjectivesWe examined the expression of Rho Kinase (ROK) isoforms in young and old rabbit’s detrusor smooth muscles (SM) during the progression of short term...Full Text Available

2008-03-01

4

Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth

PrefaceCardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation, vascular smooth muscle cell anti-migratory actions, and anti-inflammatory actions. These...Full Text Available

2009-10-01

5

Purification and partial characterization of glycosaminoglycans and proteoglycans from cultured rabbit smooth muscle cells

Smooth muscle cell (SMC) proliferation and migration are key processes that occur in the pathogenesis of atherosclerosis and post-angioplasty restenosis. In the present study, we designed locked nucleic...Full Text Available

2004-01-01

6

["3H]QNB binding and contraction of rabbit colonic smooth muscle cells

Glycosaminoglycans synthesized by cultured rabbit smooth muscle cells were isolated after incorporation of (/sup 3/H)-glucosamine into glycosaminoglycans in the presence or absence of 10% fetal bovine serum. Glycosaminoglycans were quantitated by two-dimensional electrophoresis after proteolytic digestion of the cell layers and media. The results show that the presence of serum has no effect on the chondroitin sulfate, heparan sulfate and dermatan sulfate content of the cell layers. The incorporation of (/sup 3/H)-glucosamine into hyaluronic acid of the cell layers was three times higher in the presence of serum. In the medium , the quantity of hyaluronic was two times higher in the presence of serum while the other glycosaminoglycans remained unchanged. The incorporation of (/sup 3/H)-glucosamine into hyaluronic acid was unaffected by the presence of serum. Specific proteoglycans were isolated from medium after with (/sup 35/S)-sulfate and ...

1985-01-01

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A Polyhydroxybutyrate Biodegradable Stent: Preliminary Experience in the Rabbit

The authors used radioligand binding and studies of cell contraction to characterize muscarinic receptors on dispersed smooth muscle cells from rabbit proximal and distal colon. Cells obtained after serial incubations in collagenase were used to measure binding of tritiated quinuclidinyl benzilate (["3H]QNB). At 37 degree C, specific ["3H]QNB binding was saturable and linearly related to cell number. Nonlinear regression analysis was used to determine the affinity of ["3H]QNB for its receptor. The IC_5_0 for the muscarinic agonists bethanechol and oxotremorine were 80 and 0.57 #mu#M, respectively. Hill coefficients were 0.67 for both, suggesting more complex interaction involving receptors of different affinities. In studies of cell contraction, bethanechol stimulated a dose-dependent decrease in cell length with half the maximal contraction occurring at 100 pM. These results suggest that (1) contraction is mediated by binding of bethanechol to ...

1987-01-01

8

VASCULARIZATION INHIBITOR

Purpose: The lifelong persistence of foreign bodies within the arteries may contribute to restenosis. Thus,biodegradable devices might decrease recurrence rates. Methods: Eleven polyhydroxybutyrate biodegradable stents and 13 tantalum stents were implanted into the iliac arteries of New Zealand white rabbits for up to 30 weeks. After killing the animals,the specimens were harvested, fixed in formalin, processed in paraffin,and stained. Results: Polyhydroxybutyrate instigated intense inflammatory and proliferative reactions with an increase in collagen (2.4- to 8-fold vs native segments), thrombosis and in-stentlumen narrowing (375.5-606.6 mm vs 655.6 #+-# 268.8 mm in native segments). The elastic membranes were destroyed in all specimens. The tantalum stents increased the in-stent lumen progressively (769.7 #+-# 366.6 mm vs 1309.9 #+-# 695.3 mm),penetrated the external elastic membrane, and increased mural collagen content (6- to 8.6-fold vs native segments). ...

2002-03-01

9

J-STORE (Japan)

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2008-01-25

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Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure

British Library Electronic Table of Contents (United Kingdom)

Hsp20, referred to as HspB6, is constitutively expressed in various tissues. Specifically, HspB6 is most highly expressed in different types of muscle including vascular, airway, colonic, bladder, and uterine smooth muscle; cardiac muscle; and skeletal muscle. It can be phosphorylated at Ser-16 by both cAMP- and cGMP-dependent protein kinases (PKA/PKG). Recently, Hsp20 and its phosphorylation have been implicated in multiple physiological and pathophysiological processes including smooth muscle relaxation, platelet aggregation, exercise training, myocardial infarction, atherosclerosis, insulin resistance and Alzheimer's disease. In the heart, key advances have been made in elucidating the significance of Hsp20 in contractile function and cardioprotection over the last decade. This mini-rev...

2011-01-01

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Benzyl carbamyl analogue of lignocaine: vasodepressor mechanism of action.

Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosterone

1. The benzyl carbamyl analogue of lignocaine [2-(diethylaminoacetamido)-3-carbamyl-4-methyl-5-benzylpyrrole] at an intravenous dose of 4 mg/kg caused a blood pressure decrease of 54 mmHg. 2. A greater hypotensive effect was observed in hypertensive compared to normotensive animals. Anaesthesia magnified the vasodepressor effect in both groups. 3. The analogue did not possess centrally-mediated effects on blood pressure but exerted its hypotensive effect via a peripheral mechanism. 4. The analogue produced a relaxant effect on intestinal and vascular smooth muscle while exerting minimal effects on muscarinic, sympathetic, or ganglionic nicotinic receptors. 5. The analogue exhibited less cardiac depressant action on left ventricular rate (dp/dt) and force of contraction than lignocaine. 6. Lethal effects for the analogue were first observed at 16 mg/kg following intravenous administration and at 500 mg/kg following intraperitoneal ...

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Rapidly adapting receptors in a rabbit model of mitral regurgitation

Aldosterone has been suggested to elicit vessel contraction via a nongenomic mechanism. We tested this proposal in microdissected, perfused rabbit renal afferent arterioles. Aldosterone had no effect on internal diameter in concentrations from 10(-10) to 10(-5) mol/L, but aldosterone abolished the ability of 100 mmol/L KCl to induce vascular contraction. The inhibitory effect of aldosterone was observed from 1 pmol/L. The inhibitory effect was significant after 5 minutes and maximal after 20 minutes and was fully reversible. Actinomycin D (10(-6) mol/L) prolonged the effect of aldosterone. The effect was abolished by the mineralocorticoid receptor antagonist spironolactone (10(-7) mol/L) but not by the glucocorticoid receptor antagonist mifepristone (10(-6) mol/L). The K+-mediated increase of intracellular calcium concentration in afferent arterioles was not affected by aldosterone. Mineralocorticoid receptor was detected by reverse ...

2003-01-01

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Natriuretic peptides in vascular physiology and pathology.

Unlike in normal rabbits, pulmonary rapidly adapting receptors (RARs) in rabbits with chronic mitral regurgitation (MR) do not respond to small changes in extravascular...Full Text Available

1999-12-15

14

Relaxant effects of hexosamines on isolated small human placental arteries

Four major natriuretic peptides have been isolated: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and Dendroaspis-type natriuretic peptide (DNP). Natriuretic peptides play an important role in the regulation of cardiovascular homeostasis maintaining blood pressure and extracellular fluid volume. The classical endocrine effects of natriuretic peptides to modulate fluid and electrolyte balance and vascular smooth muscle tone are complemented by autocrine and paracrine actions that include regulation of coronary blood flow and, therefore, myocardial perfusion; modulation of proliferative responses during myocardial and vascular remodeling; and cytoprotective anti-ischemic effects. The actions of natriuretic peptides are mediated by the specific binding of these peptides to three cell surface receptors: type A natriuretic peptide receptor (NPR-A), type B natriuretic peptide ...

2008-01-01

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Forkhead box protein P1 as a downstream target of transforming growth factor-b induces collagen synthesis and correlates with a more stable plaque phenotype

Wharton's jelly contains large amounts of hyaluronic acid, and glucosamine is an important constituent of this macromolecule. In order to evaluate the placental vascular effects of this aminosugar, small chorionic and stem villous arteries were dissected from placental specimens obtained at normal term vaginal deliveries (n = 15). Ring preparations were mounted in organ baths, and isometric wall tensions were measured. Glucosamine and its epimer galactosamine (5 X 10(-4) to 10(-2) M) produced marked relaxation of contractions induced by PGF2 alpha (10(-5) M) in both chorionic and stem villous arteries. The effect was unchanged after pretreatment with atropin, propranolol and indomethacin. The relaxant effect of the neutral sugar mannose was less pronounced compared with that of the hexosamines. Total tissue concentrations of placental hexosamines have been reported within the range needed to produce placental vascular relaxation in the present ...

1987-01-01

16

British Library Electronic Table of Contents (United Kingdom)

Objective: Atherosclerosis is an inflammatory disease, modulated by plaque stabilizing and de-stabilizing cell populations such as infiltrating monocytes and vascular smooth muscle cells (vSMCs). Transcription factors regulating proliferation and differentiation of atherosclerosis relevant cell types are of interest in this context. The forkhead box transcription factor FoxP1 modulates monocyte differentiation. We studied FoxP1 expression in atherosclerotic tissue, correlated FoxP1 expression with plaque characteristics and identified associations between FoxP1 and plaque proteins. Methods: 116 Atherosclerotic plaques from carotid endarterectomy samples were histologically classified (fibrous, fibroatheromatous, atheromatous) and subjected to semi-quantitative protein analysis. Macrophage,...

2011-01-01

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Data of spleen-scintiscanning after splenectomy

Proteomic Profiling of Mesenchymal Stem Cell Responses to Mechanical Strain and TGF-B1

In 65 adult rabbits of both sexes (2.5 to 6 kg) the following salvaging procedures were performed after simulated trauma: (1) Continuous suture line; (2) closure with fibrin sealant after temporary clamping; (3) hemisplenectomy with omental wrap; (4) suture fixation of fragments and slices of spleen tissue to the peritoneum; (5) suture fixation of spleen fragments to the omentum; (6) extraperitoneal subcutaneous transposition of spleen cubes. In addition, the likelihood of spontaneous splenosis was examined in a preliminary study involving 5 animals by introducing unattached spleen meal and fragments. Scanning was repeated 4 to 12 weeks postoperatively. The functional competence of minor parenchymal islands was also investigated with well counter measurements of organ and muscle tissue homogenates. Spontaneous splenosis after abdominal injuries was not found to be the rule. Salvaging procedures at the natural vascular hilus by sutures, fibrin ...

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Direct photoaffinity labeling by nucleotides of the apparent catalytic site on the heavy chains of smooth muscle and Acanthamoeba myosins

Mesenchymal stem cells (MSCs) are a potential source of smooth muscle cells (SMCs) for constructing tissue-engineered vascular grafts. However, the details of how specific combinations of vascular microenvironmental factors regulate MSCs are not well understood. Previous studies have suggested that both mechanical stimulation with uniaxial cyclic strain and chemical stimulation with transforming growth factor {beta}1 (TGF-{beta}1) can induce smooth muscle markers in MSCs. In this study, we investigated the combined effects of uniaxial cyclic strain and TGF-{beta}1 stimulation on MSCs. By using a proteomic analysis, we found differential regulation of several proteins and genes, such as the up-regulation of TGF-{beta}1-induced protein ig-h3 (BGH3) protein levels by TGF-{beta}1 and up-regulation of calponin 3 protein level by cyclic strain. At the gene expression level, BGH3 was induced by TGF-{beta}1, ...

2009-10-12

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Horizontal Transmissible Protection against Myxomatosis and Rabbit Hemorrhagic Disease by Using a Recombinant Myxoma Virus

The heavy chains of Acanthamoeba myosins, IA, IB and II, turkey gizzard myosin, and rabbit skeletal muscle myosin subfragment-1 were specifically labeled by radioactive ATP, ADP, and UTP, each of which is a substrate or product of myosin ATPase activity, when irradiated with uv light at 0"0C. With UTP, as much as 0.45 mol/mol of Acanthamoeba myosin IA heavy chain and 1 mol/mol of turkey gizzard myosin heavy chain was incorporated. Evidence that the ligands were associated with the catalytic site included the observations that reaction occurred only with nucleotides that are substrates or products of the ATPase activity; that the reaction was blocked by pyrophosphate which is an inhibitor of the ATPase activity; that ATP was bound as ADP; and that label was probably restricted to a single peptide following limited subtilisin proteolysis of labeled Acanthamoeba myosin IA heavy chain and extensive cleavage with CNBr and trypsin of labeled turkey gizzard myosin heavy ...

20

[Pericardio-mediastinal vascular dysplasia (report of a case)].

We have developed a new strategy for immunization of wild rabbit populations against myxomatosis and rabbit hemorrhagic disease (RHD) that uses recombinant viruses based on a naturally attenuated field...Full Text Available

2000-02-01

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In vitro corrosion, cytotoxicity and hemocompatibility of bulk nanocrystalline pure iron

PMID:5050423

1972-06-23

22

The Pharmacokinetics of Nimodipine After Oral Administration in Rabbits with Hepatic Failure

Bulk nanocrystalline pure iron rods were fabricated by the equal channel angular pressure (ECAP) technique up to eight passes. The microstructure and grain size distribution, natural immersion and electrochemical corrosion in simulated body fluid, cellular responses and hemocompatibility were investigated in this study. The results indicate that nanocrystalline pure iron after severe plastic deformation (SPD) would sustain durable span duration and exhibit much stronger corrosion resistance than that of the microcrystalline pure iron. The interaction of different cell lines reveals that the nanocrystalline pure iron stimulates better proliferation of fibroblast cells and preferable promotion of endothelialization, while inhibits effectively the viability of vascular smooth muscle cells (VSMCs). The burst of red cells and adhesion of the platelets were also substantially suppressed on contact with the nanocrystalline pure iron in blood ...

2010-12-01

23

Magnetic Resonance Imaging of Rabbit Kidney after Renal Vein Ligation

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2006-02-01

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Chromosomal Analysis of Meiosis and Mitosis in New Zealane White Rabbit

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1993-05-01

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Bioadhesive Drug Delivery System for the Intravesical Administration of Paclitaxel in Rabbits

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2001-08-01

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A Comparative Study About the Effect of Nonablative Laser and Thermal energy on Rabbit Knee Joint Capsular Properties

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2004-04-01

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Computed tomography of the mediastinal lesion

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2001-06-01

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Plugging the biopsy tract in rabbit liver : gelfoam, fibrin sealant and NBCA

Authors retrospectively analyzed the CT findings of mediastinal lesions in surgically or clinically confirmed 37 cases at Kosin Medical College during recent 4 years from September 1979 to August 1983. 1. Among 37 caes, malignant lymphoma were 7 cases, thymoma and vascular lesion or anomaly were 5 cases respectively, benign teratoma and tuberculous mediastinal lymphadenitis and neurogenic tumor were 4 cases respectively, pericardial cyst were 2 cases, bronchogenic cyst, non-specific cyst, pancreatic pseudocyst, mesothelioma, Bochdalek hernia was 1 case respectively. 2. The sex ratio between male and female was about 1 : 1 and the majority of the patients with malignant lymphoma and teratoma was under 20 years old. 3. CT findings of the each mediastinal lesion. 1) Primary mediastinal malignant lymphoma. (1) A large, matted, continuous and midline-crossing mass was observed in the superior and the anterior mediastinums in all cases. (2) In 3 cases, irregular lower ...

1984-09-15

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Short-term inhibition of ADP-induced platelet aggregation by clopidogrel ameliorates radiation-induced toxicity in rat small intestine.

To evaluate the effect of plugging the biopsy tract in rabbit liver and the pathologic changes caused by plugging materials. Thirty-two New Zealand White rabbits were divided into four groups (eight rabbits in each) and compared with one another. They were labeled group A (control), B (gelfoam), C (fibrin sealant) or D (NBCA). the liver was exposed and biopsied with an 18G disposable biopsy gun. The inner Tru-cut needle was withdrawn and plugging was undertaken through the outer cannula of the biopsy gun. Bleeding times of each material were compared. The rabbits were sacrificed and pathologically evaluated for 17 days.

1998-07-01

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Fabrication and in vitro deployment of a laser-activated shape memory polymer vascular stent

Endothelial dysfunction and increased platelet aggregation may be involved in the pathogenesis of normal tissue radiation toxicity. This study assessed clopidogrel, an inhibitor of ADP-induced platelet aggregation, as a modulator of intestinal radiation injury (radiation enteropathy). Rat small intestine was exposed to 21 Gy X-radiation. Clopidogrel (20 mg/kg/day) or vehicle was administered from 2 days before to 10 days after irradiation. Structural radiation injury, neutrophil infiltration, smooth muscle cell proliferation, collagen content, and TGF-beta1 expression were assessed 2 weeks (early phase) and 26 weeks (delayed phase) after irradiation, using quantitative histology and immunohistochemistry, morphometry, and real-time fluorogenic probe RT-PCR. Irradiated intestine exhibited significant histopathologic injury, reduced mucosal surface area, vascular sclerosis, intestinal wall fibrosis, increased collagen content, and increased ...

2002-01-01

31

Astrocyte-Derived Vascular Endothelial Growth Factor Stabilizes Vessels in the Developing Retinal Vasculature

BackgroundVascular stents are small tubular scaffolds used in the treatment of arterial stenosis (narrowing of the vessel). Most vascular stents are metallic and are deployed either...Full Text Available

32

Vascular Effects of Photodynamic and Pulsed Dye Laser Therapy Protocols

Vascular endothelial growth factor (VEGF) plays a critical role in normal development as well as retinal vasculature disease. During retinal vascularization, VEGF is most strongly expressed by not yet...Full Text Available

33

Fractal parameters and vascular networks: facts & artifacts

Background and ObjectivePulsed dye laser (PDL) treatment of cutaneous vascular lesions is associated with variable and unpredictable efficacy. Thus, alternative treatment...Full Text Available

2008-11-01

34

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.

BackgroundSeveral fractal and non-fractal parameters have been considered for the quantitative assessment of the vascular architecture, using a variety of test specimens and of computational...Full Text Available

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Magnetic resonance imaging and computational fluid dynamics (CFD) simulations of rabbit nasal airflows for the development of hybrid CFD/PBPK models

The effects of homologous plasma HDL and VHDL fractions on established atherosclerotic lesions were studied in cholesterol-fed rabbits. Atherosclerosis was induced by feeding the animals a 0.5% cholesterol-rich...Full Text Available

1990-04-01

36

Impact of genetic changes to the CRPV genome and their application to the study of pathogenesis in vivo

The percentages of total airflows over the nasal respiratory and olfactory epithelium of female rabbits were calculated from computational fluid dynamics (CFD) simulations of steady-state inhalation....Full Text Available

2009-05-01

37

Cryoglobinaemia in rabbits hyperimmunized with a polyvalent pneumococcal vaccine

The cottontail rabbit papillomavirus (CRPV)/rabbit model has been used to study oncogenicity and immunogenicity of different antigens from the papillomavirus genome and has therefore served...Full Text Available

2007-02-20

38

Comparison of azlocillin, ceftizoxime, cefoxitin, and amikacin alone and in combination against Pseudomonas aeruginosa in a neutropenic-site rabbit model.

During the anamnestic response, the sera of four rabbits immunized with a polyvalent pneumococcal vaccine contained large amounts of cryoglobulins belonging to the G and M immunoglobulin classes. These...Full Text Available

1965-10-01

39

Comparative pharmacokinetics of two prodrugs of zidovudine in rabbits: enhanced levels of zidovudine in brain tissue.

The efficacy of beta-lactam antibiotics and amikacin alone and in various combinations against Pseudomonas aeruginosa was studied in a rabbit model simulating a closed-space infection in a locally neutropenic...Full Text Available

1984-05-01

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The Effect of Acute Hemodilution on Carotid Blood Flow, Arterial Blood Gas Analysis and Acid-Base Balance in Rabbits

The pharmacokinetics of two prodrugs of zidovudine (AZT), 1,4-dihydro-1-methyl-3-[(pyridylcarbonyl)oxy] ester and isoleucinyl ester (DPAZT and IAZT, respectively), were investigated in a rabbit model...Full Text Available

1993-04-01

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Fluidic-controlled automatic rabbit system

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2005-09-01

42

Biological parameters of transgenic rabbits

... v. 15(10) p. 445-449. automation control equipment fluid flow fluidic control

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British Library Electronic Table of Contents (United Kingdom)

The investigations were conducted at the Center of Biotechnology and Molecular Diagnostics of the All-Russian Animal Husbandry Research Institute, where a number of valuable transgenic animals (rabbits, sheep, and pigs) have been produced over the course of 20 years. The article presents the blood indices of control and transgenic rabbits with an integrated insulin gene.

2011-01-01

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Proteomic Functional Characterization of Bovine Stromal Vascular Cells from Omental, Subcutaneous and Intramuscular Adipose Depots

Impairing Effects of Acute Glucose Overload on Calcium Homeostasis in Vascular Endothelial Cells

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2011-01-01

45

Community Structure, Productivity, and Nutrient Uptake of the Vascular Plants in the Wetlands of the Asan-Lake

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1998-12-01

46

Reticulate eruptions. Part 1: Vascular networks and physiology

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2000-06-01

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British Library Electronic Table of Contents (United Kingdom)

Abstract Reticulate pattern is one of the most important dermatological signs of a pathological process involving the superficial vascular networks. Vascular malformations, such as cutis marmorata congenita telangiectasia and benign forms of livedo reticularis, and sinister conditions, such as meningococcal meningitis or Sneddon's syndrome, can all present with a reticulate pattern. The clinical presentation and morphology is determined by the nature and extent of the underlying pathology and the involvement of a particular vascular network. This review has been divided into four instalments. In the present paper, we discuss the anatomy and physiology of the complex network of vascular structures that support the function of the skin and subcutis.

2011-01-01

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Smooth Particle Hydrodynamics for Surf Zone Waves

Fundamental study of heat transfer augmentation of tube inside surface by cascade smooth surface-turbulence promoters

... Zou, S. and RA Dalrymple, ``Coastal Sediment Transport Simulation by Smoothed Particle Hydrodynamics,'' Journal of Waterways, Ports, Coastal ...

2011-05-15

49

Vascular ATP-sensitive potassium channels are over-expressed and partially regulated by nitric oxide in experimental septic shock

Fundamental study of heat transfer augmentation of tube inside surface by cascade smooth surface-turbulence promoters

1987-03-01

50

British Library Electronic Table of Contents (United Kingdom)

Purpose To study the activation and expression of vascular (aorta and small mesenteric arteries) potassium channels during septic shock with or without modulation of the NO pathway. Methods Septic shock was induced in rats by peritonitis. Selective inhibitors of vascular KATP (PNU-37883A) or BKCa [iberiotoxin (IbTX)] channels were used to demonstrate their involvement in vascular hyporeactivity. Vascular response to phenylephrine was measured on aorta and small mesenteric arteries mounted on a wire myograph. Vascular expression of potassium channels was studied by PCR and Western blot, in the presence or absence of 1400W, an inducible NO synthase (iNOS) inhibitor. Aortic activation of the transcriptional factor nuclear factor-kappaB (NF-?B) was assessed by electrophoretic mobility shift as...

2011-01-01

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Vascular Access Procedures (Central Catheters)

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

... the major types of vascular access catheters: A peripherally inserted central catheter (PICC) is a long catheter that extends ... the procedure performed? A midline catheter and some peripherally inserted central catheter (PICC) lines may be inserted at your ...

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The association of circulating inflammatory markers with recurrent vascular events after stroke: a prospective cohort study

Vascular permeability factor (VPF) is an Mr 40-kD protein that has been purified from the conditioned medium of guinea pig line 10 tumor cells grown in vitro, and increases fluid permeability from blood...Full Text Available

1989-11-01

53

Role of Cytokinin and Auxin in Shaping Root Architecture: Regulating Vascular Differentiation, Lateral Root Initiation, Root Apical Dominance and Root Gravitropism

BackgroundInflammatory markers may be associated with recurrent vascular events after stroke. We aimed to: (1) determine the association between interleukin-6, C-reactive...Full Text Available

2011-01-01

54

Review: Interventional radiology in peripheral vascular disease

• Background and Aims Development and architecture of plant roots are regulated by phytohormones. Cytokinin (CK), synthesized in the root cap, promotes cytokinesis, vascular...Full Text Available

2006-05-01

55

Retinal Fundus Image Registration via Vascular Structure Graph Matching

Peripheral vascular diseases (PVD) are referred to as diseases affecting the blood vessels other than the heart and the brain. Interventional endovascular treatment whenever feasible has become the...Full Text Available

2008-05-01

56

Radiation modification of vascular prostheses

Motivated by the observation that a retinal fundus image may contain some unique geometric structures within its vascular trees which can be utilized for feature matching, in this paper, we proposed...Full Text Available

2010-01-01

57

Poikiloderma atrophicans vasculare as a pointer to reticulosis of the skin

The radiation method has been employed for the modification of the surface of vascular prostheses by means of acrylamide. As a result of the treatment, the tightness of the prosthesis walls was improved as well as an increase of surface hydrophilicity. Upon autoclaving, stable binding of polyacrylamide to prostheses is achieved. (author).

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Patency rate and complications of polytetrafluoroethylene grafts compared with polyurethane grafts for hemodialysis access

A case of reticulosis of the skin (mycosis fungoides) terminating in reticulum cell sarcoma is described where the features of poikiloderma atrophicans vasculare had been present for 40 years. The...Full Text Available

1975-07-01

59

Non-Invasive Stem Cell Therapy in a Rat Model for Retinal Degeneration and Vascular Pathology

BackgroundThe survival of hemodialysis patients requiring dialysis depends on the long-term functioning and patency of the vascular access. Prosthetic vascular grafts are inevitably...Full Text Available

2010-10-01

60

Impairment and recovery of left motor function in patients with right hemiplegia.

BackgroundRetinitis pigmentosa (RP) is characterized by progressive night blindness, visual field loss, altered vascular permeability and loss of central vision. Currently there...Full Text Available

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Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates?

OBJECTIVE: To assess the motor function of the left, supposedly unaffected, limbs of patients with an acute right vascular hemiplegia. METHODS: Fifteen patients with an acute vascular right hemiplegia...Full Text Available

1997-01-01

62

The inhibition of the primary interaction between "1"2"5I-labeled human hemoglobin and rabbit anti-human hemoglobin sera: a sensitive radioimmunoassay technique

Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes...Full Text Available

2008-06-01

63

Antimicrobial Susceptibility of Haemophilus ducreyi

... ammonium compounds antigen-antibody reactions hemoglobin inhibition

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Closed smooth strings on a torus

The susceptibility of 19 isolates of Haemophilus ducreyi from a recent chancroid outbreak and four reference strains was determined in vitro to 13 antimicrobial agents. The rabbit intradermal...Full Text Available

1978-04-01

65

Silver nanoparticles inhibit VEGF-and IL-1?-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells

The free energy of a gas of closed strings with extrinsic curvature (smooth strings) is evaluated on a torus. This is compared with the free energy of a collection of free particles, and hence the mass spectrum of excitations of the smooth strings is deduced. It is found that above a critical value of the coupling constant of the curvature term the spectrum is free of tachyons. Furthermore, there are no massless spin-2 excitations. The absence of massless spin-2 fields is a consequence of the fact that the smooth-string theory is not modular invariant.

1988-02-15

66

Evaluation of peripheral vascular disease by intravenous digital subtraction angiography with the Fuji computed radiography (FCR) system

The aim of this study is to determine the effects of silver nanoparticles (Ag-NP) on vascular endothelial growth factor (VEGF)-and interleukin-1 beta (IL-1β)-induced vascular permeability, and...Full Text Available

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Evaluation of peripheral vascular disease by intravenous digital subtraction angiography with the Fuji computed radiography (FCR) system

Intravenous digital subtraction angiography using Fuji computed radiography system (FCR-DSA) was used to evaluate 57 preoperative patients with clinical manifestations of peripheral vascular disease of lower extremity. With its high contrast resolution and good special resolution, image of FCR-DSA could offer optimal information of vascular abnormality in lower extremity distal to midfoot for the diagnosis and the choice of management.

1987-03-01

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Heterophyle antibodies causing false positive radio-immunoassay results a case report

Intravenous digital subtraction angiography using Fuji computed radiography system (FCR-DSA) was used to evaluate 57 preoperative patients with clinical manifestations of peripheral vascular disease of lower extremity. With its high contrast resolution and good special resolution, image of FCR-DSA could offer optimal information of vascular abnormality in lower extremity distal to midfoot for the diagnosis and the choice of management. (orig.).

1987-01-01

69

Changes in the Lung Lipids of Rabbits and Guinea-pigs Exposed to the Inhalation of Silica Dust

A case report of falsely elevated serum hormone values measured by radio-immunoassay (RIA) is described. The radio-immunoassays concerned have a first antibody raised in rabbits and mostly a separation technique based on a second antibody-solid phase system. The presence of heterophyle (anti-rabbit) antibodies in patients' serum is proved.

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Prognostic value of dynamic MRI in assessing post-traumatic femoral head vascularity

Eight rabbits and 24 guinea-pigs were exposed to a silica dust cloud of about 40,000 pp./ml. (0·3-3·0 μ) and killed at four-weekly intervals up to 30 weeks. The guinea-pigs showed...Full Text Available

1960-01-01

71

The binding of polyribosomes to smooth and rough endoplasmic-reticulum membranes (Short Communication)

The vascular status of femoral heads in the post-traumatic period of intracapsular femoral neck fracture (ICFNF) remains uncertain until the patient actually develops avascular necrosis (AVN). Several methods for predicting the viability of femoral head have been reported, that are not effective or widely used because of unreliability, potential complications, and technical difficulties. The present study involved the use of Dynamic MRI (DMRI) in assessing femoral head vascularity to predict AVN. The role of DMRI was studied prospectively in 30 patients with 31 ICFNF. Fractures were divided in to three types (Type A, B, or C) based on the femoral head vascularity shown by dynamic curve patterns on MRI evaluation. Type A was preserved vascularity, Type B was some decrease in vascularity but still viable while Type C was significantly reduced vascularity. These ...

2009-06-15

72

Stimulation of albumin endocytosis by cationized ferritin in cultured aortic smooth muscle cells.

In vitro the binding of polyribosomes to smooth endoplasmic-reticulum membranes is more sensitive to ionic strength than is the binding to rough endoplasmic-reticulum membranes. Polyribosomes...Full Text Available

1973-04-01

73

Smooth Muscle Hypertrophy Following Partial Bladder Outlet Obstruction Is Associated with Overexpression of Non-Muscle Caldesmon

Anionic microdomains within the aortic smooth muscle cell (SMC) surface glycocalyx represent a potential barrier to the endocytosis of anionic plasma proteins. Cultured SMCs exposed briefly to cationized...Full Text Available

1985-12-01

74

P2X purinoceptors mediate an endothelium-dependent hyperpolarization in longitudinal smooth muscle of anterior mesenteric artery in young chickens

Partial bladder outlet obstruction (PBOO) induces remodeling of urinary bladder smooth muscle (detrusor). We demonstrate an increase in bladder wall mass, muscle bundle size, and a threefold increase...Full Text Available

2004-02-01

75

ALTERATION OF THE PKC-MEDIATED SIGNALING PATHWAY FOR SMOOTH MUSCLE CONTRACTION IN OBSTRUCTION-INDUCED HYPERTROPHY OF THE URINARY BLADDER

Background and purpose:The chicken anterior mesenteric artery contains an outer longitudinal smooth muscle layer, whose neural regulation remains to be elucidated. ATP evokes a depolarization...Full Text Available

2009-10-01

76

How Much Does the Midline Incision Add to Urethral Diameter After Tubularized Incised Plate Urethroplasty? An Experimental Animal Study

Normal urinary bladder function requires contraction and relaxation of the detrusor smooth muscle (DSM). The DSM undergoes compensatory hypertrophy in response to partial bladder outlet obstruction...Full Text Available

2009-07-01

77

British Library Electronic Table of Contents (United Kingdom)

PurposeWe objectively quantified the gain in urethral diameter and the effect of stenting after tubularized incised plate urethroplasty in a rabbit hypospadias model. Materials and MethodsWe created a hypospadias model in 12 New Zealand white male rabbits by excising the ventral urethra. A 3 cm tattoo line was made longitudinally in the dorsal urethral plate midline. Two weeks later a 2 cm relaxing incision was made in the middle part of the tattooed line. The stretched incision width between the tattooed edges was measured, followed by urethral plate tubularization. Six rabbits were stented and 6 were nonstented. Two weeks later the animals were sacrificed and the distance separating the tattoo was measured at the midpoint of the tattooed line. Transverse sections at this point were exami...

2011-01-01

78

Effect of host nutrition on immunity and local immune response of rabbits to Obeliscoides cuniculi

Absorption of lead from the bronchial region of the lung

In a series of experiments carried out on young and adult rabbits the effect of isocaloric low protein diets containing 4% or 8% protein compared with a diet containing 21% protein on Obeliscoides cuniculi infection was studied. The pathogenesis, resistance and local immunity were assessed after single infections with 10,000 larvae or reinfection with 5000 larvae. Live weight gain was reduced in young and adult rabbits fed the low protein diets, but the establishment of parasites was not substantially influenced by protein deprivation. However, development of worms in the histotrophic phase and parasite fecundity were impaired in association with the low protein diet. Moreover, mild anaemia as well as changes in the mucosal immune response as a result of infection were related to the level of dietary protein. (author). 30 refs, 6 figs, 5 tabs.

1987-05-11

79

[Special cases of vascular injuries by war projectiles].

Experiments have been reported previously in which lead-212 ions with lead carrier were instilled into the lungs of anaesthetised rabbits. Experiments were also reported in which bismuth-207 chloride was instilled into rabbit lung. To check that the chloride compound was cleared in the same way as ions instilled in isolation, lead-203 chloride has been instilled in three rabbits. Measurements of absorption of ionic lead have been repeated using the radon-222 daughter, lead-214. Rates of clearance from the lung of "2"0"3Pb as the chloride and "2"1"2Pb ions are compared, and retention functions are derived. Clearance from the lung of "2"1"4Pb ions is also shown, and retention functions are derived. (U.K.).

1978-03-01

80

The vascular pattern and viability of microvascularized rib grafts based on periosteal circulation--an experimental study

The author resumes what is actually known about the behaviour of war projectiles in the target (wound ballistics). This is function of their nature, their velocity, their air trajectory. The difference between lesions due to slow moving bullets and these due to projectiles with a high kinetic energy is outlined. The last ones create, through the temporary cavitation effect, lesions at distance from the residual visible tract, particularly in the vascular conduits. The therapeutic conclusions, which derive from those ballistic behaviours, are briefly described in matter of repair of vascular war injuries [Acta chir. belg., 1982, 82, 457-461]. PMID:7148288

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81

The CMV early enhancer/chicken beta actin (CAG) promoter can be used to drive transgene expression during the differentiation of murine embryonic stem cells into vascular progenitors.

Previous reports have stressed the importance of the nutrient blood supply in rib grafts transferred by microvascular anastomoses. In the present experimental study, we have demonstrated that a rib graft transferred by microvascular anastomoses based on periosteal vessels can survive; vascular clearing studies demonstrated that the vascularity of these grafts extends not only into the cortex but the medulla as well. The relative facility of harvesting these grafts (compared with those based on nutrient vessels) should make them the favored choice. Technetium bone scintigraphy proved accurate in the assessment of both vascular pattern and microanastomotic patency. Tetracycline labeling did not correlate well with the patency of a rib graft's pedicle blood supply.

1984-11-01

82

Spatiotemporal Evolution of the fMRI Response to Ultrashort Stimuli

Udgivelsesdato: 2008-null

2008-01-01

83

Pulmonary Vasodilator Responses to Nitroprusside and Nitroglycerin in the Dog

The specificity of the hemodynamic response function (HRF) is determined spatially by the vascular architecture and temporally by the evolution of hemodynamic changes. The stimulus duration...Full Text Available

2011-01-26

84

Cancer cells cause vascular endothelial cell (vEC) retraction via 12(S)HETE secretion; the possible role of cancer cell derived microparticle.

The objective of this study was to determine the direct actions of nitroprusside and nitroglycerin on the pulmonary vascular bed in the intactchest dog. These widely used nitrogen oxide-containing vasodilator...Full Text Available

1981-03-01

85

Aphakic macular oedema following prosthetic lens implantation.

PMID:17103063

2006-11-12

86

A Summary Risk Score for the Prediction of Alzheimer Disease in Elderly Persons

Fluorescein angiography of the iris was performed on patients with plastic lens implants with cystoid oedema of the macula, and the nature of the vascular changes was compared with controls provided...Full Text Available

1977-05-01

87

Tissue distribution of brain-thymus shared antigens recognized by anti-brain xenosera in the rat, dog and man.

ObjectiveTo develop a simple summary risk score for the prediction of Alzheimer disease in elderly persons based on their vascular risk profiles.DesignFull Text Available

2010-07-01

88

The reactivity of thiol groups and the subunit structure of aldolase

A comparative and quantitative study of the tissue distribution of brain-thymus shared antigens was carried out using rabbit antisera to rat, dog and human brain homogenates, assayed on rat, dog and...Full Text Available

1979-03-01

89

The metabolism of the isomeric decalones

1. Seven unique carboxymethylcysteine-containing peptides have been isolated from tryptic digests of rabbit muscle aldolase carboxymethylated with iodo[2-¹⁴C]acetic acid in 8m-urea....Full Text Available

1970-04-01

90

Taloximine, a new respiratory stimulant with bronchodilator properties

1. The metabolism of (±)-cis-1-, (±)-trans-1-, (±)-cis-2- and (±)-trans-2-decalone in the rabbit...Full Text Available

1966-08-01

91

Some aspects of the pharmacology of an homologous series of choline esters of fatty acids

1. A novel phthalazine analogue taloximine (1-hydroxyimino-4(2-dimethyl-aminoethoxy)-1,2-dihydrophthalazine monohydrochloride monohydrate) stimulated respiration in conscious rabbits at doses of 7...Full Text Available

1969-02-01

92

Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits.

The pharmacological effects of a series of fatty acid-choline esters have been studied on the isolated rabbit heart, the isolated guinea-pig ileum and the rat stomach. The effect changed with increasing...Full Text Available

1957-03-01

93

Regulation of hyaluronan secretion into rabbit synovial joints in vivo by protein kinase C

A regulatory locus on the Staphylococcus aureus chromosome, designated sar, is involved in the expression of cell wall proteins, some of which are potentially important in the pathogenesis of endocarditis....Full Text Available

1994-05-01

94

Pathway to Licensure for Protective Antigen-based Anthrax Vaccines ...

Hyaluronan (HA) is important for joint cavitation, lubrication, volume regulation and synovial fluid drainage but little is known about the regulation of joint HA synthesis/secretion in vivo....Full Text Available

2003-07-15

95

Naturally occurring double-stranded RNA and immune responses. III. Immunogenicity and antigenicity in animals.

... Weiss, S., D. Kobiler, H. Levy, H. Marcus, A. Pass, N. Rothschild, and Z ... of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits ...

96

Molecular and immunological comparison of human dihydropteridine reductase in liver, cultured fibroblasts and continuous lymphoid cells.

Naturally occurring, double-stranded RNA (ds-RNA)) was immunogenic when injected into mice, rats, guinea-pigs, rabbits, dogs and baboons. The response to native material administered intravenously (i.v.)...Full Text Available

1975-12-01

97

Location of an epitopic site on epiglycanin by molecular immunoelectron microscopy.

An antiserum was raised in a rabbit against highly purified human liver dihydropteridine reductase (EC 1.6.99.7). Dihydropteridine reductase from human liver, in human cultured fibroblasts and in continuous...Full Text Available

1981-07-01

98

INTRAVITREAL HUMAN IMMUNE GLOBULIN IN A RABBIT MODEL OF STAPHYLOCOCCUS AUREUS TOXIN-MEDIATED ENDOPHTHALMITIS: A POTENTIAL ADJUNCT IN THE TREATMENT OF ENDOPHTHALMITIS

Antibodies of the IgM type present in rabbit anti-epiglycanin antiserum were purified by (NH4)2SO4 precipitation and by ion-exchange, affinity and gel-filtration chromatography. After papain treatment...Full Text Available

1985-04-01

99

Head position modulates optokinetic nystagmus

ABSTRACTObjectivesTo test the feasibility of human immune globulin (IG, Gamimune N, 10%) as a new treatment for endophthalmitis, the ocular tolerance, distribution,...Full Text Available

2004-12-01

100

GAMMA GLOBULIN METABOLISM IN RABBITS DURING THE ANAMNESTIC RESPONSE.

Orientation and movement relies on both visual and vestibular information mapped in separate coordinate systems. Here, we examine how coordinate systems interact to guide eye movements of rabbits....Full Text Available

2011-08-01

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101

GNF - Wilson Inlet

Wastenet

... The costal plain still supports Jarrah (Eucalyptus marginata ) forest, dense woodlands, coastal heath and diverse swamplands. Many species of plants are endemic. 20 species of mammals and 12 species of introduced mammals including with feral pigs, rabbits and foxes of particular concern....

102

Fourier Transform Infrared Imaging and MR Microscopy Studies Detect Compositional and Structural Changes in Cartilage in a Rabbit Model of Osteoarthritis

1. Gamma globulin metabolism and distribution were studied employing rabbit gamma globulin (RGG)I(131) 24 times in 13 control rabbits. Similar studies were performed before and during the ananmestic response in 4 rabbits previously sensitized with a polyvalent pneumococcal vaccine. 2. During the ananmestic response, gamma-globulin levels increased from 1.0 to 6.0 gm/100 ml, and the gamma-globulin pool increased from 0.7 to 4.7 gm/kg. There was no change in the intravascular-extravascular partition of gamma globulin. 3. Gamma globulin degradation increased from 0.06 to 0.33 gm/kg/day during the 28 days of the immunization period while gamma globulin synthesis increased even further to average 0.47 gm/kg/day. Following the attainment of elevated gamma globulin levels the fractional rate of RGG-I(131) turnover increased from 8.0 to 12.5 per cent/day. 4. No differences were noted in the metabolism of homologous or autologous ...

1964-04-01

103

Effect of 9-(2-Hydroxyethoxymethyl)guanine on Herpesvirus-Induced Keratitis and Iritis in Rabbits

Assessment of subtle changes in the primary macromolecular components of cartilage, proteoglycan (PG) and collagen, is critical for the diagnosis of early stages of osteoarthritis (OA), but...Full Text Available

2007-03-01

104

Changes in Rabbit and Cow Lens Shape and Volume upon Imposition of Anisotonic Conditions

Drugs used for the inhibition of DNA viruses, such as iododeoxyuridine, adenine arabinoside, or trifluorothymidine, are not biochemically selective in their action and also interfere with normal cellular...Full Text Available

1978-12-01

105

Cerebellar cell surface antigens of mouse brain.

In vivo, mammalian lenses have the capacity to effect fully reversible changes in shape, and possibly volume, during the accommodation process. Isolated lenses also change shape...Full Text Available

2009-10-01

106

Biosynthesis and characterization of rabbit tooth enamel extracellular-matrix proteins.

Reaggregated cells from 6- to 8-day-old mouse cerebella have been used to raise antibodies in rabbits. The interaction of these antibodies with cerebellar cell surface components was assessed by cytotoxicity...Full Text Available

1975-10-01

107

Antigenic analysis of the second extra-cellular loop of the human beta-adrenergic receptors.

Tooth enamel biomineralization is mediated by enamel proteins synthesized by ameloblast cells. Two classes of proteins have been described: enamelins and amelogenins. In lower vertebrates the absence...Full Text Available

1988-05-01

108

Placental transfer of 14C-hexoprenaline. [Rabbits

Polyclonal antibodies were raised in rabbits by immunization with free peptides corresponding to positions 197-222 of the human beta 1-adrenergic receptor (beta 1 peptide) and the corresponding sequence...Full Text Available

1989-10-01

109

Self-expandable stent loaded with {sup 125}I seeds: Feasibility and safety in a rabbit model

The placental transfer of a single intravenous injection of 14C-hexoprenaline was studied in eight pregnant New Zealand white rabbits. Maternal and fetal blood was sampled intermittently for 60 minutes after the injection. An initial rapid decrease in the levels of 14C-hexoprenaline in maternal blood was followed by a second slower phase, whereas fetal levels remained insignificant. The conclusion, therefore, is that the rapid improvement in fetal heart rate after the administration of a single maternal intravenous injection of hexoprenaline in the treatment of fetal distress is due to the action on the uterus and/or on maternal cardiovascular function, and not to direct stimulation of the fetus.

1982-02-01

110

Neuropilin-1/GIPC1 Signaling Regulates ?5?1 Integrin Traffic and Function in Endothelial Cells

Objective: To evaluate technical feasibility and acute and subacute radiotolerance of a self-expandable stent loaded with {sup 125}I seeds in the rabbit esophagus. Methods: A self-expandable stent designed for esophageal application was made of 0.16 mm nitinol wire and loaded with {sup 125}I seeds (CIAE-6711). Twenty-seven stents with three different radioactive dosages (n = 9 in each dosage group) were implanted in the esophagus of healthy rabbits, while nine stents alone were used as controls. The stents were perorally deployed into the esophagus under fluoroscopic guidance. Radiological follow-up included plain chest film, CT scan, and barium esophagography which were undertaken in all rabbits of each group at 2, 4, and 8 weeks, respectively, which were correlated to histopathological findings. The stented esophageal segments along with their adjacent tissues were harvested for histopathological examinations. Results: ...

2007-02-15

111

Circulation, bone scans, and tetracycline labeling in microvascularized and vascular bundle implanted rib grafts

Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, Nrp1 null embryos display vascular...Full Text Available

2009-01-01

112

Adaptation of a cubic smoothing spline algortihm for multi-channel data stitching at the National Ignition Facility

The circulation in microvascularized rib grafts has been compared with that in conventional rib grafts and in those augmented by a direct vascular bundle implantation into the bone grafts. A new experimental model has been designed to correlate vascular perfusion, bone scan patterns, tetracycline labeling, and histological findings in these bone grafts. Posterior microvascularized rib grafts were found to have a circulatory pattern identical to that of the normal rib. Failed microvascularized rib grafts were revascularized more slowly than conventional rib grafts. Vascular bundles implanted into rib grafts remained patent and increased the rate of revascularization. The stripping or preservation of periosteum had no observable effects on the rate or pattern of conventional rib graft revascularization. The circulation in rib grafts was accurately reflected in technetium 99 bone scans, as was the patency of the anastomoses of ...

1984-11-01

113

Vascular complications following 1500 consecutive living and cadaveric donor renal transplantations: A single center study

Some diagnostics at the National Ignition Facility (NIF), including the Gamma Reaction History (GRH) diagnostic, require multiple channels of data to achieve the required dynamic range. These channels need to be stitched together into a single time series, and they may have non-uniform and redundant time samples. We chose to apply the popular cubic smoothing spline technique to our stitching problem because we needed a general non-parametric method. We adapted one of the algorithms in the literature, by Hutchinson and deHoog, to our needs. The modified algorithm and the resulting code perform a cubic smoothing spline fit to multiple data channels with redundant time samples and missing data points. The data channels can have different, time-varying, zero-mean white noise characteristics. The method we employ automatically determines an optimal smoothing level by minimizing the Generalized Cross Validation (GCV) score. In ...

2010-12-28

114

Assessment of arterial tumor vascularity in small hepatocellular carcinoma. Comparison between color Doppler ultrasonography and radiographic imagings with contrast medium: dynamic CT, angiography, and CT hepatic arteriography

The aim of this study was to document vascular complications that occurred following cadaveric and living donor kidney transplants in order to assess the overall incidence of these complications at our center as well as to identify possible risk factors. In a retrospective cohort study, 1500 consecutive renal transplant recipients who received a living or cadaveric donor kidney between December 1988 and July 2006 were evaluated. The study was performed at the Nemazee Hospital, Shiraz, Iran. The assessment of the anatomy and number of renal arteries as well as the incidence of vascular complications was made by color doppler ultrasonography, angiography, and/or surgical exploration. Clinically apparent vascular complications were seen in 8.86% of all study patients (n = 133) with the most frequent being hemorrhage (n = 91; 6.1%) followed by allograft renal artery stenosis (n = 26; 1.7%), renal artery thrombosis (n = 9; ...

115

Use of electron backscattering for smoothing the discharge in electron-beam-controlled lasers: computations

Hepatocellular carcinoma (HCC) is characterized by tumor vascularization from the hepatic artery. The objective of our work was to compare color Doppler ultrasonography (CDU), including power Doppler ultrasonography (PDU) with radiographic imagings with contrast medium in regard to the detection of the arterial tumor vascularity of small hepatocellular carcinomas (HCC). We examined 42 small HCC lesions 2 cm or less in diameter in 37 patients for arterial tumor vascularity by conventional CDU, PDU, dynamic computed tomography (dCT), digital subtraction angiography (DSA), and CT hepatic arteriography (CTA). Color images were detected in 25 (59.5%) and 28 (66.7%) of the 42 lesions with conventional CDU and PDU, respectively, and tumor vascularity was detected in 26 (61.9%) by dCT, 23 (54.8%) by DSA, and 29 (69.0%) by CTA. Tumor vascularity could be detected in 51.9% by PDU and CTA, ...

2000-10-01

116

On the Reinhardt Conjecture

... Smith, RC Westinghouse Research Labs., Pittsburgh v. 25(5) p. 292-295.

117

Radiofrequency ablation of the gastrointestinal tract with a stent-like electrode: experimental study

In 1934, Reinhardt asked for the centrally symmetric convex domain in the plane whose best lattice packing has the lowest density. He conjectured that the unique solution up to an affine transformation is the smoothed octagon (an octagon rounded at corners by arcs of hyperbolas). This article offers a detailed strategy of proof. In particular, we show that the problem is an instance of the classical problem of Bolza in the calculus of variations. A minimizing solution is known to exist. The boundary of every minimizer is a differentiable curve with Lipschitz continuous derivative. If a minimizer is piecewise analytic, then it is a smoothed polygon (a polygon rounded at corners by arcs of hyperbolas). To complete the proof of the Reinhardt conjecture, the assumption of piecewise analyticity must be removed, and the conclusion of smoothed polygon must be strengthened to smoothed octagon.

2011-01-01

118

Mechanical stability of the diamond-like carbon film on nitinol vascular stents under cyclic loading

To assess the technical feasibility of a newly designed stent-like electrode in rabbits. A stent-like electrode was knitted from a single thread of nitinol wire and interconnected to a generator using similar wire. In order to gauge the extent of radiofrequency ablation (RFA), we measured the depth of the ablated area in cow liver using a combination of 180-sec time intervals and 20- watt power increments. For data processing, Cox regression analysis was used. RFA was also applied to the small intestine of rabbits using this stent-like electrode under six different sets of conditions: 10 watts for 1 min, 10 watts for 2 mins, 20 watts for 1 min, 20 watts for 2 mins, 30 watts for 1 min, and 30 watts for 2 mins. To determine the gross and microscopic findings, six animals were sacrificed immediately after the procedure and the results obtained under the different sets of conditions were correlated. Eight rabbits were monitored ...

2003-03-01

119

Diesel exhaust inhalation induces heat shock protein 70 expression in vivo

The mechanical stability of diamond-like carbon (DLC) films coated on nitinol vascular stents was investigated under cyclic loading condition by employing a stent crimping system. DLC films were coated on the vascular stent of a three dimensional structure by using a hybrid ion beam system with rotating jig. The cracking or delamination of the DLC coating occurred dominantly near the hinge connecting the V-shaped segments of the stent where the maximum strain was induced by a cyclic loading of contraction and extension. However the failures were significantly suppressed as the amorphous Si (a-Si) buffer layer thickness increased. Interfacial adhesion strength was estimated from the spalled crack size in the DLC coating for various values of the a-Si buffer layer thickness.

2008-12-01

120

British Library Electronic Table of Contents (United Kingdom)

Exposure to urban air pollution is an independent risk factor for increased cardiovascular diseases. Heat shock protein 70 (HSP70) has been implicated in the pathogenesis of vascular dysfunction and cardiovascular diseases. This study has been designed to determine whether inhalation of urban air induces HSP70 expression in the lung and blood as well as the association of HSP70 and air pollution-induced vascular dysfunction. Apolipoprotein E (Apo-E) deficient mice were exposed to diesel exhaust (DE) either acutely (3 days, 200 or 400 g/m3 for 6 h/day) or chronically (7 weeks, 200 or 400 g/m3 for 6 h/day). HSP70 was measured in the lung using immunohistochemistry, and in the plasma by ELISA. Abdominal aorta rings were used to determine vascular functional responses. Chronic DE-exposure incr...

2011-01-01

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121

Clinical Evaluation of the Zilver Vascular Stent for Symptomatic Iliac Artery Disease

British Library Electronic Table of Contents (United Kingdom)

PurposeTo evaluate the safety and effectiveness of the Zilver vascular stent in the treatment of de novo or restenotic lesions in the external and common iliac arteries.Materials and MethodsRegardless of the results of an initial percutaneous transluminal angioplasty (PTA), 151 consecutive patients were implanted with Zilver vascular stents (Cook, Bloomington, Ind) in up to two stenotic (?10 cm) or occluded (?5 cm) atherosclerotic lesions of the external or common iliac arteries. The primary endpoint was the rate of major adverse events within 9 months after the procedure. Major adverse events were defined as death, myocardial infarction, target lesion revascularization, and limb loss. Secondary endpoints included acute procedural success, 30-day clinical success, 9-month pat...

2008-01-01

122

Studies on localization of calcitonin gene-related peptide (CGRP) in the thyroid-parathyroid complex.

Phosphorylation of sites 3 and 2 in rabbit skeletal muscle glycogen synthase by a multifunctional protein kinase (ATP-citrate lyase kinase)

Calcitonin gene-related peptide (CGRP) was localized by an immunocytochemical technique in the thyroid-parathyroid complexes of rat, guinea pig, rabbit, and in normal human thyroids and parathyroids. Human medullary carcinomas and parathyroid adenomas were also studied. In man and all animal species examined CGRP was present in the parafollicular cell, however, in guinea pigs only in small amounts. Except in rabbits, presence of CGRP was demonstrated in nerves of the thyroid and parathyroid capsule as well as in the nerve fibers of the capsular blood vessels. In the thyroid of guinea pigs CGRP was also noted in nerve fibers and in blood vessel walls between follicles. CGRP was also present in the parathyroid glands of rat and man, in nerve fibers localized between parathyroid cells. In rabbit the parafollicular cells between parathyroid cells also expressed CGRP immunoreactivity. No CGRP was noted in the parathyroids of the ...

1987-01-01

123

var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2

A multifunctional protein kinase, purified from rat liver as ATP-citrate lyase kinase, has been identified as a glycogen synthase kinase. This kinase catalyzed incorporation of up to 1.5 mol of and)2numberSPO4/mol of synthase subunit associated with a decrease in the glycogen synthase activity ratio from 0.85 to a value of 0.15. Approximately 65-70% of the TUPO4 was incorporated into site 3 and 30-35% into site 2 as determined by reverse phase high performance liquid chromatography. This multifunctional kinase was distinguished from glycogen synthase kinase-3 on the basis of nucleotide and protein substrate specificities. Since the phosphate contents in glycogen synthase of sites 3 and 2 are altered in diabetes and by insulin administration, the possible involvement of the multifunctional kinase was explored. Glycogen synthase purified from diabetic rabbits was phosphorylated in vitro by this multifunctional kinase at only 10% of the rate compared to synthase ...

1985-10-05

124

Vascular plants of the Hanford Site

BackgroundThe pathogenicity of Plasmodium falciparum is in part due to the ability of the parasitized red blood cell (pRBC) to adhere to intra-vascular host cell...Full Text Available

125

Transport into retina measured by short vascular perfusion in the rat.

An updated listing of the vascular plants of the Hanford Site is provided, along with discussions of how humans may interact with local plants and have influenced the regional flora. Based on examinations of herbarium collections at the Westinghouse Hanford Company, Pacific Northwest Laboratory, Washington State University, and Brigham Young University, 590 vascular plant species have been identified on or near the Hanford Site. This is more than twice the number of species on previously published lists of Hanford Site vascular plants. A review of the plant species that are currently listed as endangered, threatened, sensitive, or otherwise of concern to the Washington State Natural Heritage Program and the Federal Fish and Wildlife Service is included. Color photographs of selected species are included to aid identification. Lists are provided of the Hanford Site plant species that could be used as food and medicinal ...

1992-07-01

126

Transmural distribution of extracellular purines in isolated guinea pig heart.

1. The short duration cerebrovascular perfusion method for measuring permeability of the blood-brain barrier has been adapted to measuring transport into the retina. 2. The method has been characterized...Full Text Available

1993-10-01

127

Subcellular Localization of Expansin mRNA in Xylem Cells12

The purine adenosine appears to be involved in regulation of coronary vascular tone. Little is known concerning the levels and distribution of adenosine and related purines in the extracellular fluid...Full Text Available

1991-01-15

128

Study of Stent Deployment Mechanics Using a High-Resolution X-ray Imaging Detector

Terminal differentiation of many vascular cells involves cell wall changes. Cells first elongate their primary wall, then lay down a lignified secondary wall, which is often followed by digestion of...Full Text Available

2000-06-01

129

Scalp Angiosarcoma Remission with Bevacizumab and Radiotherapy without Surgery: A Case Report and Review of the Literature

To treat or prevent some of the 795,000 annual strokes in the U.S., self-expanding endo-vascular stents deployed under fluoroscopic image guidance are often used. Neuro-interventionalists need...Full Text Available

2011-03-01

130

Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth

Angiosarcoma (AS) is a rare and aggressive vascular neoplasm with very poor prognosis. Patients with extensive cutaneous AS who are not surgical candidates have very limited options since there is no...Full Text Available

2011-01-01

131

Recent US Patterns and Predictors of Prevalent Diabetes among Acute Myocardial Infarction Patients

MicroRNAs (miRs) can regulate many cellular functions, but their roles in regulating responses of vascular endothelial cells (ECs) to mechanical stimuli remain unexplored. We hypothesize that the physiological...Full Text Available

2010-02-16

132

Prognostic Significance of Peritumoral Lymphatic Vessel Density and Vascular Endothelial Growth Factor Receptor 3 in Invasive Squamous Cell Cervical Cancer

Background. Diabetes mellitus (DM) confers high vascular risk and is a growing national epidemic. We assessed clinical characteristics and prevalence of diagnosed DM among patients...Full Text Available

133

Plasminogen-¹²⁵I responses in dogs to a single injection of urokinase and typhoid vaccine and to vascular injury

Cervical cancer is known to metastasize primarily by the lymphatic system. Dissemination through lymphatic vessels represents an early step in regional tumor progression, and the presence of lymphatic...Full Text Available

134

Physiologic Responses to Infrarenal Aortic Cross-Clamping during Laparoscopic or Conventional Vascular Surgery in Experimental Animal Model: Comparative Study

In vivo plasminogen responses to various stimuli were studied. Plasminogen-¹²⁵I was prepared and used first for metabolic studies of plasminogen in control dogs. The average results were:...Full Text Available

1972-06-01

135

Lower extremity vascular stenting for a post-traumatic pseudoaneurysm in a young trauma patient

The aim of this study was to compare the hemodynamic and ventilatory effects of prolonged infrarenal aortic cross-clamping in pigs undergoing either laparotomy or laparoscopy. 18 pigs were used for...Full Text Available

2008-01-01

136

Increased NO bioavailability in aging male rats by genistein and exercise training: using 4, 5-diaminofluorescein diacetate

Endovascular treatment of post-traumatic pseudoaneurysms has become a viable, less invasive option when compared to open repair. Due to the relative youth of this technology, studies have yet to be...Full Text Available

2011-04-01

137

Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species.

BackgroundSeveral kinds of anti-oxidants have drawn a lot of intension for their benefits on vascular protection. In addition, it has been demonstrated that exercise training could...Full Text Available

138

Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administration

Simian retroperitoneal fibromatosis (RF) is a vascular fibroproliferative neoplasm which has many morphological and histological similarities to human Kaposi's sarcoma (KS). Like epidemic KS in AIDS...Full Text Available

1997-05-01

139

Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans

Neuropilin-1 (NRP1) acts as a co-receptor for class 3 semaphorins and vascular endothelial growth factor and is an attractive angiogenesis target for cancer therapy. In addition to the transmembrane...Full Text Available

2009-07-01

140

Exploring the impact of a decision support intervention on vascular access decisions in chronic hemodialysis patients: study protocol

Neurofibromatosis type 1 (NF1) results from mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. NF1 patients display diverse clinical manifestations,...Full Text Available

2010-03-01

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141

Evaluation of Multiplexed Fluorescent Microsphere Immunoassay for Detection of Autoantibodies to Nuclear Antigens

BackgroundIn patients with Stage 5 Chronic Kidney Disease who require renal replacement therapy a major decision concerns modality choice. However, many patients defer the decision...Full Text Available

142

Enhancing Process and Data Collection Efficiency of Peripherally Inserted Central Catheter Insertion for Justification of an Intravenous Access Program.

Antibodies to extractable nuclear antigens (ENA) are found in a variety of collagen vascular diseases. Determining the individual specificities of these antibodies is extremely useful in establishing...Full Text Available

2004-11-01

143

Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network

This purpose of this paper is to describe the optimizing Peripherally Inserted Central Catheter (PICC) insertion, revising data collection strategies, estimating workloads, and calculating the financial savings generated by the vascular access nurse (VAN)...

2004-01-01

144

Dynamic NMR effects in breast cancer dynamic-contrast-enhanced MRI

ObjectivesIn old age, there are marked changes in both the structure of the liver sinusoidal endothelial cell and liver perfusion. The objective of this study was...Full Text Available

2008-04-01

145

Divergent Regulation of Angiopoietin-1 and -2, Tie-2, and Thrombospondin-1 Expression by Estrogen in the Baboon Endometrium

The passage of a vascular-injected paramagnetic contrast reagent (CR) bolus through a region-of-interest affects tissue ¹H₂O relaxation and thus MR image intensity. For longitudinal...Full Text Available

2008-11-18

146

Comparative study of the osseointegration of dental implants after different bone augmentation techniques: vascularized femur flap, non-vascularized femur graft and mandibular bone graft

SUMMARYEstrogen has an important role in the reconstruction of a new vascular network in the endometrium during each menstrual cycle; however, the underlying mechanisms...Full Text Available

2010-05-01

147

British Library Electronic Table of Contents (United Kingdom)

Abstract Objectives: The purpose of this study was to evaluate the osseointegration of the dental implants placed into the mandible augmented with different techniques in pigs. Material and methods: Four adult domestic pigs were used. Horizontal augmentation of the mandible was performed in animals by using vascularized femur flap (VFF), non-vascularized femur graft (NVFG) and monocortical mandibular block graft (MG). After 5 months of healing 10 dental implants were placed into each augmented site. The pigs were sacrificed after 3 months of healing. Undecalcified sections were prepared for histomorphometric analysis. Results: Mean bone-implant contact (BIC) values for implants placed into MG, NVFG and VFF were 57.38 11.97%, 76.5 7.88%, 76.53 8.15%, respectively. The BIC values of NVFG and...

2011-01-01

148

Characterization of Cytokinin and Adenine Transport in Arabidopsis Cell Cultures1[OA

Antioxidant Treatment Alters Peripheral Vascular Dysfunction Induced by Postnatal Glucocorticoid Therapy in Rats

Cytokinins are distributed through the vascular system and trigger responses of target cells via receptor-mediated signal transduction. Perception and transduction of the signal can occur at the plasma...Full Text Available

2008-12-01

149

A new VCAN/versican splice acceptor site mutation in a French Wagner family associated with vascular and inflammatory ocular features

BackgroundPostnatal glucocorticoid therapy in premature infants diminishes chronic lung disease, but it also increases the risk of hypertension in adulthood. Since glucocorticoid...Full Text Available

150

A Case Report of a Patient with Hereditary Hemorrhagic Telangiectasia Treated Successively with Thalidomide and Bevacizumab

PurposeTo detail the highly variable ocular phenotypes of a French family affected with an autosomal dominantly inherited vitreoretinopathy and to identify the disease gene.MethodsSixteen...Full Text Available

151

Ocular Burn: Rinsing and Healing with Ionic Marine Solutions and Vegetable Oils

Hereditary hemorrhagic telangiectasia is characterized by mucocutaneous and visceral telangiectasia and involves several organs with vascular malformations. It is an autosomal dominant disease and is...Full Text Available

152

British Library Electronic Table of Contents (United Kingdom)

Abstract Purpose: We investigated the effects of various rinsing and healing protocols on corneal wound repair and inflammation following alkali burn in rabbits. Methods: We conducted in vitro, in vivo and ex vivo studies. First, different rinse solutions were tested in vitro after incubation of ocular cells with methanol or NaOH. Cell viability was then assessed using the neutral red test (cytofluorometry). Second, NaOH was applied to rabbit corneas and associations of rinse solutions (NaCl 0.9% or controlled ionization marine solutions) with N-acetylcysteine or vegetable oils (from Calophyllum inophyllum and Aleurites moluccana) were tested in vivo. The regeneration of the corneal epithelium and the infiltration of inflammatory cells were evaluated using in vivo confocal microscopy and e...

2009-01-01

153

Hydroxyapatite coating enhances polyethylene terephthalate artificial ligament graft osseointegration in the bone tunnel

British Library Electronic Table of Contents (United Kingdom)

The purpose of this study was to investigate whether hydroxyapatite (HAp) coating could induce polyethylene terephthalate (PET) artificial ligament graft osseointegration in the bone tunnel. Twenty-four New Zealand white rabbits underwent artificial ligament graft transplantation in bilateral proximal tibia tunnels. One limb was implanted with HAp-coated PET graft, and the contralateral limb was implanted with non-HAp-coated PET graft as control. The rabbits were randomly sacrificed at four and eight?weeks after surgery. The loads to failure of the experimental group at eight?weeks were significantly higher than those of the control group (p?=?0.0057). Histologically, application of HAp coating induced new bone formation between graft and bone at eight?weeks compared with the controls. Rea...

2011-01-01

154

Heated lipiodol as an embolization agent for transhepatic arterial embolization in VX2 rabbit liver cancer model

Flow-induced changes in pial artery compliance registered with a non-invasive method in rabbits

Purpose: To evaluate the therapeutic effect of heated (60 deg. C) lipiodol via hepatic artery administration in a rabbit model of VX2 liver cancer. Materials and methods: Thirty male New Zealand white rabbits were randomly divided into three groups with 10 rabbits assigned to each group. VX2 carcinoma cells were surgically implanted into the left hepatic lobe. The tumors were allowed to grow for 2 weeks, and studies were performed until the diameter of the tumors detected by ultrasonograph reached 2-3 cm. Under anesthesia, trans-catheter hepatic arterial embolization was performed and doxorubicin-lipiodol (37 deg. C) (1 mL), lipiodol (60 deg. C) (1 mL) or control (physiological saline (37 deg. C) (1 mL)) solution was injected into the hepatic arteries of animals in the three groups. One week later, the volume of the tumor was measured by ultrasonograph again. The serum of all rabbits was collected ...

2010-02-15

155

British Library Electronic Table of Contents (United Kingdom)

Aim: This study was performed: 1) to assess the relationship between blood flow velocity in the internal carotid artery (CBFICA) and pial artery pulsation (cc-TQ) and 2) to evaluate flow-induced changes in pial artery compliance. Methods: Experiments were performed on 10 crossbred male rabbits. Heart rate (HR), blood pressure (BP), left ventricle ejection fraction (LVEF), CBFICA, the systolic-diastolic blood volume fraction in the brain circulation (CBFSDF) and cc-TQ were recorded after glucagon and acetazolamide administration. cc-TQ was measured with near-infrared transillumination back scattering sounding (NIR-T/BSS), LVEF and CBFSDF with gated scintigraphy and BP and CBFICA with electromagnetic pressure and flow transducers, respectively. Doses of drugs were chosen to exert a haemodyna...

2011-01-01

156

Vascular injuries in intestinal obstruction. The role of computed tomography; Complicazioni vascolari nelle occlusioni intestinali: ruolo della tomografia computerizzata

To study the role of dynamic magnetic resonance imaging in assessing the femoral head vascularity in intracapsular femoral neck fractures

The paper investigates computerized tomography capabilities in showing vascular complications secondary to intestinal obstruction and for assessing the site and cause of obstruction. [Italian] Scopo del lavoro e' lo studio dell'uso della tomografia computerizzata nel riconoscimento di complicanze vascolari secondarie ad occlusione intestinale e della presenza, della natura e della sede dell'ostacolo alla canalizzazione intestinale.

1999-09-01

157

To study the role of dynamic magnetic resonance imaging in assessing the femoral head vascularity in intracapsular femoral neck fractures

Intracapsular femoral neck fractures remain unsolved fractures even after improvement in techniques of diagnosis and internal fixation. Individuals who sustain displaced femoral neck fractures are at high risk of developing avascular necrosis and non-union. Although several methods for predicting the viability of femoral head have been reported, they are not effective or widely used because of unreliability, potential complications and technical difficulties. Dynamic MRI was introduced in the recent past as a simple, non-invasive technique to predict the femoral head viability after the femoral neck fractures. In this study role of dynamic MRI was studied in 30 patients with 31 intracapsular femoral neck fractures. Fractures were divided in to three types according to dynamic curve patterns on MRI evaluation and were followed up for 6 months to 2 years to observe the final outcome. Sensitivity, Specificity and the Accuracy of dynamic MRI in predicting vascularity ...

2010-09-15

158

Simulation of oil and gas production forecasts using smoothing methods

Intracapsular femoral neck fractures remain unsolved fractures even after improvement in techniques of diagnosis and internal fixation. Individuals who sustain displaced femoral neck fractures are at high risk of developing avascular necrosis and non-union. Although several methods for predicting the viability of femoral head have been reported, they are not effective or widely used because of unreliability, potential complications and technical difficulties. Dynamic MRI was introduced in the recent past as a simple, non-invasive technique to predict the femoral head viability after the femoral neck fractures. In this study role of dynamic MRI was studied in 30 patients with 31 intracapsular femoral neck fractures. Fractures were divided in to three types according to dynamic curve patterns on MRI evaluation and were followed up for 6 months to 2 years to observe the final outcome. Sensitivity, Specificity and the Accuracy of dynamic MRI in predicting vascularity ...

2010-09-01

159

A Nonparametric Mean-Variance Smoothing Method to Assess Arabidopsis Cold Stress Transcriptional Regulator CBF2 Overexpression Microarray Data

A variety of forecasting approaches have been used in the energy area. Forecast simulations provide a common basis for comparing the relative precision of different forecasting methods. This paper presents a forecast simulation made using smoothing procedures for forecasting time series. The simulation design, statistical analysis, and conclusions are provided.

1987-01-01

160

Hemodynamic characteristics of early stage hepatocellular carcinoma; In vivo evaluation with vascular imagings

Microarray is a powerful tool for genome-wide gene expression analysis. In microarray expression data, often mean and variance have certain relationships. We present a non-parametric mean-variance smoothing...Full Text Available

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161

Uteroglobin gene expression in the rabbit uterus throughout gestation and in the fetal lung. Relationship between uteroglobin and eicosanoid levels in the developing fetal lung.

Hemodynamic characteristics were studied by using in vivo vascular imaging techniques in 17 resected early stage hepatocellular carcinoma (e-HCC) by comparing them with 49 resected advanced HCCs (ad-HCC) less than 3 cm in diameter. In this study, e-HCC was defined as the nodule being uniformly composed of well-differentiated HCC or adenomatous hyperplastic nodule containing well-differentiated HCC foci within the nodule. In vivo vascular imaging techniques are as follows; US angiography with intraarterial CO{sub 2} microbubbles were performed to assess the tumor arterial vascularity, and CT during arterial portography (CTAP) was performed to assess the portal perfusion within the nodule. Of 17 e-HCC nodules 5 were hypervascular, 5 were isovascular, 4 were hypovascular, and 3 were vascular spot in hypovascular pattern in contrast to 49 ad-HCC nodules, 43 of which were hypervascular and 6 were ...

1992-04-01

162

Molecular Characterization of a Haemaphysalis longicornis Tick Salivary Gland-Associated 29-Kilodalton Protein and Its Effect as a Vaccine against Tick Infestation in Rabbits

Uteroglobin (UG) gene encodes a cytokine-like, multifunctional, antiinflammatory protein, with potent phospholipase A2-inhibitory activity. It has been suggested that during implantation this protein...Full Text Available

1995-07-01

163

TED | Profile

Wastenet

... The dawn of Bio-Mecha and a Biomechanical Revolution May 31 2011: Hi Julian, Yes, but i dont think we would ... The dawn of Bio-Mecha and a Biomechanical Revolution May 31 2011: A BBC Documentary: All Watched Over by Machines of Loving ... The dawn of Bio-Mecha and a Biomechanical Revolution May 17 2011: Ed Boyden: A light switch for neurons is an amazing ... The dawn of Bio-Mecha and a Biomechanical Revolution May 16 2011: Thank you Meher Like Spring Rabbit, its a great contribution....

164

Lytic HSV-1 infection induces the multifunctional transcription factor Early Growth Response-1 (EGR-1) in rabbit corneal cells

The use of tick vaccines in mammalian hosts has been shown to be the most promising alternative tick control method to current use of acaricides, which suffers from a number of limitations. However,...Full Text Available

1999-04-01

165

Immunological correlates for protection against intranasal challenge of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits.

BackgroundHerpes simplex virus type-1 (HSV-1) infections can cause a number of diseases ranging from simple cold sores to dangerous keratitis and lethal encephalitis. The interaction...Full Text Available

166

Growth hormone-like factor produced by the tapeworm, Spirometra mansonoides, displaces human growth hormone (hGH) from its receptors on cultured human lymphocytes

Correlates between immunological parameters and protection against Bacillus anthracis infection in animals vaccinated with protective antigen (PA)-based vaccines could provide surrogate markers to evaluate the putative protective efficiency of immunization in humans. In previous studies we demonstrated that neutralizing antibody levels serve as correlates for protection in guinea pigs (S. Reuveny et al., Infect. Immun. 69:2888-2893, 2001; H. Marcus et al., Infect. Immun. 72:3471-3477, 2004). In this study we evaluated similar correlates for protection by active and passive immunization of New Zealand White rabbits. Full immunization and partial immunization were achieved by single and multiple injections of standard and diluted doses of a PA-based vaccine. Passive immunization was carried out by injection of immune sera from rabbits vaccinated with PA-based vaccine prior to challenge with B. anthracis spores. Immunized ...

2006-01-01

167

Extended amino acid sequences around the active-site lysine residue of class-I fructose 1,6-bisphosphate aldolases from rabbit muscle, sturgeon muscle, trout muscle and ox liver.

An analogue of hGH isolated from plerocercoids of the tapeworm Spirometra mansonoides displaces ["1"2"5I]hGH from its receptors in rabbit, rat, and hamster liver membranes. Biologically, plerocercoid growth factor (PGF) is more similar to hGH than to other mammalian GH's but has not been shown to bond human cells. Receptors specific for hGH have been described on cultured human lymphocytes (IM-9). In this study, the authors compared the binding of PGF and hGH in IM-9 cells and in rabbit hepatic membranes. IM-9 lymphocytes (12 x 10"6 cells/tube) were incubated with ["1"2"5I]hGH and increasing concentrations of hGH (ng/ml) or PGF (serial dilutions) for 90 min at 30"0 C. Specific binding (B_0 - NSB) was determined for each dose of hGH or PGF and the binding curves were analyzed by logit-log regression. The results show that PGF displaced ["1"2"5I]hGH from human cells in a dose dependent manner (r = 0.98). Based on the IM-9 assay, 1 ml of the PGF ...

1986-04-13

168

Numerical simulation of shallow-water dam break flows in open channels using smoothed particle hydrodynamics

1. Amino acid sequences covering the region between residues 173 and 248 [adopting the numbering system proposed by Lai, Nakai & Chang (1974) Science 183, 1204-1206] were derived for trout (Salmo...Full Text Available

1979-11-01

169

British Library Electronic Table of Contents (United Kingdom)

SummaryA meshless numerical model is proposed to investigate shallow-water dam break flows in 1D open channels. The numerical model is to solve the shallow water equations (SWE) based on smoothed particle hydrodynamics (SPH). The concept of slice water particles (SWP) is adopted in the SPH-SWE formulation. The numerical sensitivity analysis is first performed to study the appropriate SWP number and variable smoothing length through dam break flows in an idealized 1D channel with dry/wet beds. Extensive validation by comparison with laboratory and field data is next conducted for four benchmark problems, including dam break flows through a rough flat channel, a rough bumpy channel with various downstream boundary conditions, a nonprismatic channel, and a realistic scale model of the Toce ri...

2011-01-01

170

Modelling and design of smoothing reactances. Application to air gap length calculation

Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung

A new method for analysis and design of smoothing reactances utilising two-dimensional planar models is presented in this paper. Inductance and magnetic flux density are calculated, and their results compared with those measured experimentally. The results obtained are good if compared with those measured once the machine have been built. Moreover, the method herein developed is applied to the calculation of air gap lengths in terms of the desired current and inductance. The kind of reactances studied presents windings in both limbs and air gaps in the four corners (joint of limbs and yokes). The main contribution of this paper is the presentation of a method of industrial application, to be easily developed, with a very important reduction in the time of machine calculation (due to the decrease in the number of nodes and elements compared with the three-dimensional model) for the determination of the air gap length in smoothing reactances. ...

2000-08-01

171

British Library Electronic Table of Contents (United Kingdom)

Fibroblast growth factor (FGF) signaling has been shown to regulate lung epithelial development but its influence on mesenchymal differentiation has been poorly investigated. To study the role of mesenchymal FGF signaling in the differentiation of the mesenchyme and its impact on epithelial morphogenesis, we took advantage of Fgfr2c+/? mice, which due to a splicing switch express Fgfr2b in mesenchymal tissues and manifest Apert syndrome-like phenotypes. Using a set of in vivo and in vitro studies, we show that an autocrine FGF10?FGFR2b signaling loop is established in the mutant lung mesenchyme, which has several consequences. It prevents the entry of the smooth muscle progenitors into the smooth muscle cell (SMC) lineage and results in reduced fibronectin and elastin deposition. Levels of...

2006-01-01

172

Signal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and ?-adrenoceptors

Relation of the One-Phase Stefan Problem to the Seepage of Liquids and Electrochemical Machining.

The normal physiological contraction of the urinary bladder, which is required for voiding, is predominantly mediated by muscarinic receptors, primarily the M₃ subtype, with the M₂...Full Text Available

2008-06-01

173

Noise suppression in scatter correction for cone-beam CT

The flow of water through a dam of fairly arbitrary shape is examined in the limit of large frictional drag on the flow. The relation of the problem to the one-phase Stefan problem and a problem of anodic smoothing is explored. Monotonicity and uniqueness...

1979-01-01

174

NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1

Scatter correction is crucial to the quality of reconstructed images in x-ray cone-beam computed tomography (CBCT). Most of existing scatter correction methods assume smooth scatter distributions. The...Full Text Available

2009-03-01

175

Mechanism of Catch Force: Tethering of Thick and Thin Filaments by Twitchin

Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibroblasts) are known to communicate with one another. Their interactions not only serve to support fully functional blood...Full Text Available

2009-02-27

176

Labeled Products and Our Partners | Design for the Environment...

Catch is a mechanical state occurring in some invertebrate smooth muscles characterized by high force maintenance and resistance to stretch during extremely slow relaxation. During catch, intracellular...Full Text Available

2010-01-01

177

Inversion of Love wave phase velocity using smoothness-constrained least-squares technique; Heikatsuka seiyakutsuki saisho jijoho ni yoru love ha iso sokudo no inversion

choice Charlotte NC *ecosential for smooth cooktops 2010 Jelmar, LLC Skokie IL CLR Cooktop Cleaner 2004 LotusLand Products, LLC Dallas TX *Believe -- BeSpicy Oven and Grill...

2011-08-18

178

Influence of surface heat flux ratio on heat transfer augmentation in square channels with parallel, crossed, and V-shaped angled ribs

Smoothness-constrained least-squares technique with ABIC minimization was applied to the inversion of phase velocity of surface waves during geophysical exploration, to confirm its usefulness. Since this study aimed mainly at the applicability of the technique, Love wave was used which is easier to treat theoretically than Rayleigh wave. Stable successive approximation solutions could be obtained by the repeated improvement of velocity model of S-wave, and an objective model with high reliability could be determined. While, for the inversion with simple minimization of the residuals squares sum, stable solutions could be obtained by the repeated improvement, but the judgment of convergence was very hard due to the smoothness-constraint, which might make the obtained model in a state of over-fitting. In this study, Love wave was used to examine the applicability of the smoothness-constrained least-squares technique with ABIC ...

1996-10-01

179

Influence of sea water on the fatigue strength and notch sensitivity of a plasma nitrided B-Mn steel

The paper investigates the effect of the wall heat flux ratio on the local heat transfer augmentation in a square channel with two opposite in-line ribbed walls for Reynolds numbers from 15,000 to 80,000. The square channel composed of 10 isolated copper sections has a length-to-hydraulic diameter ratio of 20. The rib height-to-hydraulic diameter ratio is 0.0625 and the rib pitch-to-height ratio equals 10. Six ribbed side to smooth side wall heat flux ratios are studied for four rib orientations. The results show that the ribbed side wall heat transfer augmentation increases with increasing ribbed side to smooth side wall heat flux ratios, but the reverse is true for the smooth side wall heat transfer augmentation. The average heat transfer augmentation of the ribbed side and smooth side wall decreases slightly with increasing wall heat flux ratios. The effect of wall heat flux ratio reduces with ...

1992-10-01

180

ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine

Notched and smooth cylindrical plasma nitrided (PN) and quench and tempered (Q and T) steel specimens made of a B-Mn SS2131 ({approx}AISI 15B21H) steel have been exposed to constant amplitude plane reversed bending corrosion fatigue tests (R = -1) at 47 Hz in sea water. S - N curves show that sea water suppresses the fatigue limit and reduces fatigue strength (especially at long lives) of smooth and notched Q and T and PN specimens. Plasma nitriding improves the corrosion fatigue resistance of Q and T specimens; this is associated with the good corrosion resistance of {epsilon} and {gamma}`-phases, the enhancement of corrosion and fatigue by compressive residual stresses, and the consumption of H{sup +} ions during reduction of nitrogen. This improvement is more significant for smooth specimens and for long lives. Notch sensitivity of Q and T and PN specimens decreases with fatigue life. Pitting corrosion, cyclic applied ...

1998-06-01

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181

Geometrical Symmetry in Symmetric Galerkin BEM.

BackgroundAnimals carrying genetic mutations have provided powerful insights into the role of interstitial cells of Cajal (ICC) in motility. One classic model is...Full Text Available

2010-05-01

182

Further assembly required: construction and dynamics of the endoplasmic reticulum network

We consider a symmetric boundary integral formulation associated with a mixed boundary value problem defined on a domain Omega is an element of the set of real numbers(2) with piecewise smooth boundary Gamma. We assume that Omega is mapped onto itself by ...

2001-01-01

183

Differential Regulation of PDE5 Expression in Left and Right Ventricles of Feline Hypertrophy Models

The endoplasmic reticulum (ER) is a continuous membrane system comprising the nuclear envelope, ribosome-studded peripheral sheets and an interconnected network of smooth tubules extending throughout...Full Text Available

2010-07-01

184

Cavity detection by the electric method: the 3-dimensional case

BackgroundThough long known to affect smooth muscle biology, recent studies indicate that phosphodiesterase 5 (PDE5) is also expressed in myocardium. Recognizing that the regulation...Full Text Available

185

Acetylsalicylic acid as soluble tablets

In this paper the authors prove a uniqueness theorem for the electric detection of cavities in a three dimensional solid from Cauchy data measured on the surface. The cavities, finite in number, are assumed to be insulating. The surfaces of the cavities are assumed to be smooth on the complement of a set that is, in some sense, negligible. (orig.)

2004-02-01

186

International Science & Technology Center (ISTC)

Realization of Pharmacological Tests, Development of the Specifications and Technical Documentation and Registration in the Russian Federation of Medical Products as Soluble Tablets of Acetylsalicylic Acid/Calcium Carbonate in Two Dosages Intended for use as Medical Products Smoothing, Febrifugal and Antiaggregation Action and Development of Technology of Tableting the Above-Stated Preparations

187

The diagnosis of inflammatory muscular and vascular conditions using MRT with STIR sequences

Endoluminal vascular prostheses; Endoluminale Gefaessprothesen

The role of MRT in the prebiopsy diagnosis of muscular and vascular inflammatory conditions was evaluated prospectively and an optimal method of examination was investigated. 92 patients with a suspected diagnosis of myositis (60 cases) or vasculitis (32 cases) were examined, in each case two extremities were studied using transverse T_1 and T_2 weighted SE sequences and double echo STIR sequences on a 0.5 Tesla (56 patients) or 1.5 Tesla magnet (36 patients; T5/S15 Gyroscan, Philips). The site of the biopsy depended on the MRT findings. In 41 patients the suspected diagnosis was confirmed histologically, in two patients an infective myositis was diagnosed on clinical grounds despite negative histology. MRT demonstrated muscle oedema in 86% of patients. There were negative findings after immuno-suppressive therapy (two patients), in focal myositis (3 out of 4 patients) and in one of 7 patients with untreated vasculitis. Amongst 49 patients in whom the suspected ...

188

Completing the Web of $Z_3$ - Quotients of Complete Intersection Calabi-Yau Manifolds

Endoluminal vascular prostheses that can be implanted by percutaneous routes represent the most recent development in vascular interventional radiology. Various commercially available types of prosthesis are presented and the construction principles and applications are described. At present secure indications for the implantation of endoluminal prostheses are limited to the elimination of aneurysms and arteriovenous fistulae of the large vessels near the trunk in sections that do not cross a joint. The wide use in peripheral occlusive diseases cannot yet be recommended because confirmed data are not available. (orig.) [German] Endoluminale Gefaessprothesen, die perkutan implantierbar sind, stellen die juengste Entwicklung in der vaskulaeren interventionellen Radiologie dar. Verschiedene kommerziell erhaeltliche Prothesentypen werden vorgestellt, ihr Konstruktionsprinzip und ihre Applikation erlaeutert. Die gesicherten Indikationen zur ...

2000-06-01

189

Centroid and Envelope Dynamics of High-intensity Charged Particle Beams in an External Focusing Lattice and Oscillating Wobbler

We complete the study of smooth $Z_3$-quotients of complete intersection Calabi-Yau threefolds by discussing the six new manifolds that admit free $Z_3$ actions that were discovered discovered recently by Braun. These manifolds were missed in an earlier work and complete the web of smooth $Z_3$-quotients in a nice way. We discuss the transitions between these manifolds and include also the other manifolds of the web. This leads to the conclusion that the web of $Z_3$-free quotients of complete intersection Calabi-Yau threefolds is connected by conifold transitions.

2010-01-01

190

Affine cones over Fano threefolds and additive group actions

The centroid and envelope dynamics of a high-intensity charged particle beam are investigated as a beam smoothing technique to achieve uniform illumination over a suitably chosen region of the target for applications to ion-beam-driven high energy density physics and heavy ion fusion. The motion of the beam centroid projected onto the target follows a smooth pattern to achieve the desired illumination, for improved stability properties during the beam-target interaction. The centroid dynamics is controlled by an oscillating "wobbler", a set of electrically-biased plates driven by RF voltage. __________________________________________________

2010-04-28

191

Resource Management plan for the Oak Ridge Reservation. Volume 28, Wetlands on the Oak Ridge Reservation

We address the following question: When an affine cone over a smooth Fano threefold admits an effective action of the additive group? In this paper we deal with Fano threefolds of index 1 and Picard number 1. Our approach is based on a geometric criterion from our previous paper, which relates the existence of an additive group action on the cone over a smooth projective variety X with the existence of an open polar cylinder in X. Non-trivial families of Fano threefolds carrying a cylinder were found in loc. cit. Here we provide new such examples.

2011-01-01

192

Resource Management plan for the Oak Ridge Reservation

A survey of wetlands on the Oak Ridge Reservation (ORR) was conducted in 1990. Wetlands occurring on ORR were identified using National Wetlands Inventory (NWI) maps and field surveys. More than 120 sites were visited and 90 wetlands were identified. Wetland types on ORR included emergent communities in shallow embayments on reservoirs, emergent and aquatic communities in ponds, forested wetland on low ground along major creeks, and wet meadows and marshes associated with streams and seeps. Vascular plant species occurring on sites visited were inventoried, and 57 species were added to the checklist of vascular plants on ORR. Three species listed as rare in Tennessee were discovered on ORR during the wetlands survey. The survey provided an intensive ground truth of the wetlands identified by NWI and offered an indication of wetlands that the NWI remote sensing techniques did not detect.

1991-12-01

193

Locally invasive lymphangiosarcoma in a young domestic shorthair

A survey of wetlands on the Oak Ridge Reservation (ORR) was conducted in 1990. Wetlands occurring on ORR were identified using National Wetlands Inventory (NWI) maps and field surveys. More than 120 sites were visited and 90 wetlands were identified. Wetland types on ORR included emergent communities in shallow embayments on reservoirs, emergent and aquatic communities in ponds, forested wetland on low ground along major creeks, and wet meadows and marshes associated with streams and seeps. Vascular plant species occurring on sites visited were inventoried, and 57 species were added to the checklist of vascular plants on ORR. Three species listed as rare in Tennessee were discovered on ORR during the wetlands survey. The survey provided an intensive ground truth of the wetlands identified by NWI and offered an indication of wetlands that the NWI remote sensing techniques did not detect.

1991-12-01

194

British Library Electronic Table of Contents (United Kingdom)

A 2-year-old, female spayed, domestic shorthair cat presented to the University of Missouri-Veterinary Medical Teaching Hospital (UMC-VMTH) with an approximately 11-month history of fluid-draining pockets along her ventral thorax and axillae. The skin in these regions was erythematous, and multiple areas drained a serous to serosanguinous fluid. Fluid-filled, nodules formed along the ventrum, but these nodules disappeared as fluid drained spontaneously. Histologic assessment of skin biopsies revealed areas of vascular proliferation extending along the deep margin of the section and rare instances of invasion into the superficial dermis. These vascular channels were devoid of cells, lined by variably pleomorphic endothelial cells which had a low mitotic index. Based on the mild to moderate ...

2011-01-01

195

Excessive bleeding in the floor of the mouth after endosseus implant placement: a report of two cases

British Library Electronic Table of Contents (United Kingdom)

Placement of dental implants in the interforaminal region of the edentulous mandible is considered a safe and routine surgical procedure. Hemorrhage in the floor of the mouth has been reported as a rare, potentially life-threatening complication related to the placement of implants in this region. In this case report the authors present an immediate and a delayed case of massive bleeding in the floor of the mouth after implant placement. This highly vascularized region is vulnerable and bleeding can be induced easily by instrumentation, causing a vascular trauma, usually by perforation of lingual periostium. In almost all cases the expanding hematoma formation starts during surgery. The effect of the vasoconstrictive agent in the local anesthesic combined with an injury of the lingual arte...

2010-01-01

196

Removal rate of ( sup 3 H)hyaluronan injected subcutaneously in rabbits

Effect of paraquat on microsomal lipid peroxidation in vitro and in vivo. [Rats, rabbits, man, mice

Hyaluronan is an important constituent of the extracellular matrix in skin, and recent studies suggest that there is a pool of easily removable (free) hyaluronan drained by lymph. The removal rate of free hyaluronan in skin was measured from the elimination of ({sup 3}H)hyaluronan, injected subcutaneously in 13 rabbits. The removal of radioactivity was determined from appearance of {sup 3}H in plasma. During the first 24 h after injection, 10-87% of the tracer entered blood, less in injectates with high concentrations of hyaluronan. The removal was monoexponential with a half-life of 0.5-1 day when concentration of hyaluronan was 5 mg/ml or less. When hyaluronan concentration was 10 mg/ml or higher, the removal was slow for about 24 h and then became similar to that in experiments with low hyaluronan concentration. Free hyaluronan at physiological concentrations is thus turned over with the same rate as serum albumin, supporting the concept that hyaluronan is ...

1990-08-01

197

Animal and human studies of a new /sup 99m/Tc labelled phosphine-isocyanide complex with possible applications to radionuclide ventriculography

Rat lung and liver microsomes did not undergo lipid peroxidation in the absence of iron when incubated with NADPH and concentrations of paraquat ranging from 10/sup -7/ to 10/sup -2/ M. Paraquat also did not stimulate rat liver and lung microsomal peroxidation induced by added iron and NADPH, and was inhibitory at concentrations above 10 ..mu..M. Similarly, no stimulation of peroxidation was produced by paraquat in rabbit or human lung microsomes; however, under similar conditions, paraquat enhanced NADPH/iron-dependent peroxidation in mouse lung and liver microsomes obtained from rats sacrificed at 12, 18, and 24 hr following a lethal dose of paraquat (50 mg/kg, ip), there was no loss of vitamin E or increase in susceptibility to in vitro peroxidation which would be expected if lipid peroxidation had occurred in vivo although extensive lung damage developed during this time period. These results indicate that paraquat does not cause pulmonary toxicity by ...

1980-01-01

198

Placental transfer of 14C-hexoprenaline

A new /sup 99m/Tc-phosphine-isocyanide complex with the general structure (/sup 99m/Tc (DEPE)/sub 2/(CNR)/sub 2/)/sup +/ has been synthesised and tested in animals and one human. In three animal species (rat, rabbit, dog), the complex is an efficient myocardial imaging agent, while in humans it remains in the blood pool. The complex is 100% protein bound in animals and humans, but whereas in humans it is attached to a 51.5 kdalton protein (probably prealbumin), in rabbits it appears to be bound to a larger macromolecule (M.W.>100 kdalton). The efficiency of the complex for blood pool labelling was tested in a human volunteer and compared with the standard in vivo red cell labelling technique with stannous pyrophosphate. A satisfactory radionuclide angiogram could be performed with less than 370 MBq of the complex. The count rate for the complex (cps/MBq) was 15% higher than that obtained with the labelled red cells and the absence of splenic ...

1987-04-01

199

Mineral analysis in experimental corneal scars. An EDAX study

The placental transfer of a single intravenous injection of 14C-hexoprenaline was studied in eight pregnant New Zealand white rabbits. Maternal and fetal blood was sampled intermittently for 60 minutes after the injection. An initial rapid decrease in the levels of 14C-hexoprenaline in maternal blood was followed by a second slower phase, whereas fetal levels remained insignificant. The conclusion, therefore, is that the rapid improvement in fetal heart rate after the administration of a single maternal intravenous injection of hexoprenaline in the treatment of fetal distress is due to the action on the uterus and/or on maternal cardiovascular function, and not to direct stimulation of the fetus.

1982-02-01

200

Use of receptor affinity chromatography in purification of the growth hormone-like factor produced by plerocercoids of the tapeworm Spirometra mansonoides.

Central penetrating excisional wounds were made in the corneas of 12 rabbits and 10 trout. The scar tissue and the surrounding cornea were compared using a new method for assessing inorganic elements in the cornea: the scanning electron microscopy and energy dispersive analysis of x-ray (EDAX). Semiquantitative determination of inorganic elements within the range of atomic numbers 9-93 in the periodic system was performed, comparing the relative concentration of those elements in the scar tissue to the surrounding cornea. Results showed that calcium was the only element higher in the healing wound than in the surrounding cornea.

1988-01-01

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201

Study of proton therapy on malignant tumors. Effects in twenty-four hours after proton irradiation

The plerocercoid stage of the tapeworm Spirometra mansonoides produces a functional analog of human growth hormone (hGH). Among the similarities between plerocercoid growth factor (PGF) and hGH is competition for the same receptors on rabbit liver membranes. To take advantage of this characteristic in a purification scheme for PGF, rabbit liver microsomes were solubilized in Triton X-100 and the hGH receptors were purified over an hGH affinity column. The purified receptors from six rabbit livers were coupled to Affi-Gel-10 to create a receptor affinity column which was used to purify PGF. Chromatography of crude PGF over the receptor column resulted in a 1044 fold increase in specific activity. SDS-PAGE in the presence of 2-mercaptoethanol showed that the affinity-purified PGF contained three protein bands with apparent Mrs of 27.5 K, 22 K, and 16.7 K. Injections of the partially-purified PGF into hypophysectomized rats ...

1988-01-01

202

Species comparison of acute inhalation toxicity of ozone and phosgene

We irradiated proton beams on the ears of rabbits and the Harding-Passey mouse melanoma and observed their morphological change. We used 52 MeV proton beams from the INS-FM cyclotron. We adjusted the energy of the proton beams to be at the plateau part of the Bragg curve, at the half-way point of the Bragg peak, and at the Bragg peak. The amount of radiation was 5000rad in each case. The Harding-Passey mouse melanoma was transplanted into the subcutan of a three week old mouse. In this experiment, we used tumors, the diameter of which grew up to 1.5-2cm in 2-3 weeks after the transplantation. Using the jroscope, we observed both lightly and severely damaged cells. Using proton irradiation with the Bragg peak located at depth of 1mm in the rabbit's ears, we studied the change in the tissue. Irradiated epidermis fell off and was eroded because of radiation damage, but the rear surface of the rabbit's ears ...

1983-01-01

203

Vascular filtration function in galactose-fed versus diabetic rats: The role of polyol pathway activity

A comparison of the concentration-response effects of inhaled ozone (O/sub 3/) and phosgene (COCl/sub 2/) in different species of laboratory animals was made in order to better understand the influence of the choice of species in inhalation toxicity studies. The effect of 4-h exposures to ozone at concentrations of 0.2, 0.5, 1.0, and 2.0 ppm, and to COCl/sub 2/ and 0.1, 0.2, 0.5, and 1.0 ppm was determined in rabbits, guinea pigs, rats, hamsters, and mice. Lavage fluid protein (LFP) accumulation 18-20 h after exposure was used as the indicator of O3- and COCl/sub 2/-induced pulmonary edema. All species had similar basal levels of LFP (250-350 mg/ml) when a volume of saline that approximated the total lung capacity was used to lavage the collapsed lungs. Ozone effects were most marked in guinea pigs, which showed significant effects at 0.2 ppm and above. Mice, hamsters, and rats showed effects at 1.0 ppm O3 and above, while rabbits responded ...

1986-01-01

204

True aneurysm originating from the costocervical trunk: surgical excision for recurrence after successful proximal coil embolization.

These studies were undertaken to assess the effects of increased galactose (v increased glucose) metabolism via the polyol pathway on vascular filtration function in the kidneys, eyes, nerves, and aorta. Quantitative radiolabeled tracer techniques were used to assess glomerular filtration rate (GFR) and regional tissue vascular clearance of plasma 131I-bovine serum albumin (BSA) in five groups of male Sprague-Dawley rats: nondiabetic controls, streptozotocin-diabetic rats, nondiabetic rats fed a 50% galactose diet, diabetic rats treated with sorbinil (an aldose reductase inhibitor), and galactose-fed rats treated with sorbinil. Sorbinil was added to the diet to provide a daily dose of approximately .2 mmol/kg body weight. After 2 months of diabetes or galactose ingestion, albumin clearance was increased twofold to fourfold in the eye (anterior uvea, choroid, and retina), sciatic nerve, aorta, and kidney; GFR was increased approximately twofold ...

1990-07-01

205

Transbrachial arterial digital subtraction angiography

A rare, true aneurysm of a branch of the right subclavian artery is described. Transcatheter coil embolization of the feeder artery was successful in obliterating blood flow into the aneurysm and the mass reduced in size. However, the aneurysm reenlarged over the next week of follow-up due to development and enlargement of the collateral vascular network. Extirpation of the aneurysm was performed. Histopathological examination revealed a true aneurysm. PMID:11833847

2002-01-01

206

Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

27 cases including 7 outpatients, underwent intraarterial DSA using 4-F nylon catheter, by transbrachial arterial approach. Much of DSAs were performed in Fuji Computed Radiography (FCR), which has high spatial resolution. In all cases, image quality satisfied clinical demands. No major complication occured in this series. Transbrachial arterial digital subtraction angiography is excellent and safe method for screening of vascular disease. (author).

1985-01-01

207

Practical approach to the loss of smell

The management of CNS tumors is limited by the blood-brain barrier (BBB), a vascular interface that restricts the passage of most molecules from the blood into the brain. Here we show that phage particles...Full Text Available

2011-01-04

208

Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing

Loss of the sense of smell can be easily confirmed in any physician's office by having the patient try to identify various odors. The etiology of anosmia can be extremely varied, including nasopharyngeal disorders such as rhinitis and tumors; neurologic conditions such as head trauma, neoplasms, vascular lesions and infections of the central nervous system; viral infections; familial and congenital disorders; drugs; industrial exposure; endocrine diseases, and several other disorders. The prognosis of anosmia is guarded, and its treatment depends on the etiology.

1982-09-01

209

Distinct Roles of Nox1 and Nox4 in Basal and Angiotensin II-Stimulated Superoxide and Hydrogen Peroxide Production

sFlt-1 (soluble Flt-1) potently inhibits angiogenesis by binding extracellularly to VEGF (vascular endothelial growth factor). In the present paper, we report that hypoxia down-regulates sFlt-1 expression...Full Text Available

2011-06-01

210

Correct diagnosis of vascular encasement and longitudinal extension of hilar cholangiocarcinoma by four-channel multidetector-row computed tomography

NADPH oxidases are major sources of superoxide (O₂^∸) and hydrogen peroxide (H₂O₂) in vascular cells. Production of these reactive oxygen species...Full Text Available

2008-11-01

211

Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27^kip1in rats

Accurate diagnosis of local invasion of hilar cholangiocarcinomas is challenging due to their small size and the anatomic complexity of the hepatic hilar region. On the other hand, the correct diagnosis of local invasion is essential for assuring the possibility of curative surgery. The purpose of this study was to evaluate the feasibility of four-channel multidetector-row computed tomography (MDCT) in the assessment of vascular and bile duct involvement, by which we could obtain useful information for the surgical management of hilar cholangiocarcinoma. The subjects were 18 patients for whom the extent of tumor invasion was surgically and pathologically confirmed. All patients underwent preoperative multiphasic CT scanning by MDCT. Arterial and portal dominant phases were acquired using a detector configuration of 1.25 mm x 4 mm, and both axial and multiplanar reconstructed images were interpreted. Longitudinal extension was evaluated up to second-order branches. ...

2009-01-01

212

An activated renin-angiotensin system maintains normal blood pressure in aryl hydrocarbon receptor heterozygous mice but not in null mice

BackgroundPulmonary vascular structure remodeling (PVSR) is a hallmark of pulmonary hypertension. P27^kip1, one of critical cyclin-dependent kinase inhibitors, has been...Full Text Available

2010-01-01

213

?₂ integrins are required for skin homing of primed T cells but not for priming naive T cells

It has been postulated that fetal vascular abnormalities in aryl hydrocarbon receptor null (ahr^−/−) mice may alter cardiovascular homeostasis in adulthood....Full Text Available

2010-07-15

214

?_1A/B-Knockout mice explain the native ?_1D-adrenoceptor's role in vasoconstriction and show that its location is independent of the other ?₁-subtypes

β₂ integrins are of critical importance for leukocyte extravasation through vascular endothelia and for T cell activation. To elucidate the role of β₂ integrins...Full Text Available

2002-01-15

215

Half-BPS M2-brane orbifolds

Background and purpose:Theoretically, three α₁-adrenoceptor subtypes can interact at the signalling level to alter vascular contraction or at the molecular level...Full Text Available

2009-12-01

216

Fundamental study of heat transfer augmentation by smooth turbulence surface promotors

Smooth (at least 1/2)-BPS Freund-Rubin backgrounds of eleven-dimensional supergravity of the form AdS_4 x X^7 have been recently classified. Requiring that amount of supersymmetry forces X to be a spherical space form, whence isometric to the quotient of the round 7-sphere by a freely-acting finite subgroup of SO(8). The classification is given in terms of ADE subgroups of the quaternions embedded in SO(8) as the graph of an automorphism. In this paper we extend this classification by dropping the requirement that the background be smooth, so that X is now allowed to be an orbifold of the round 7-sphere. We find that if the background is (more than 1/2)-BPS, then it is automatically smooth in accordance with the homogeneity conjecture, but that there are many half-BPS orbifolds, most of them new. The classification is now given in terms of pairs of ADE subgroups of quaternions fibred over the same finite group. We classify ...

2010-01-01

217

Smoothing of laser energy deposition by gas jets

In the utilization of the thermal energy by ocean temperature difference and factory waste heat, the high performance heating surfaces in pipes from which scale can be removed are required. As the method of removing scale, the method using sponge balls seems most suitable, but for applying this method, as the form of the protrusions attached to the inner surfaces of pipes, smooth circular are form is desirable. The promotion of heat transfer with the rows of circular arc protrusions like this is strongly related to the mode of flow and such structure as separation, recirculation flow, readhesion and turbulent energy generation. In this study, as the basic research to optimize the heating surface with the rows of smooth protrusions, the flow characteristics and the heat transfer characteristics including the turbulent structure of the wake of protrusions were experimentally determined, and the essence of the heat transfer characteristics was to ...

1985-01-01

218

Numerical simulation of fluid flow and heat transfer in a concentric tube heat exchanger

Smoothing of laser beam non-uniformities using gas jets has been studied. The experiment has been performed with the PALS (Prague Asterix Laser System) laser working at 0.44 ?m with an intensity of about 1015 W/cm2. The laser beam has been split in two by a prism thus creating an artificial large-scale non-uniformity (? 90 ?m). We recorded time resolved and static images of laser-gas jet interaction with and without an Al target. Multi 1-dimensional and 2-dimensional simulations show that such interaction acts redistributing the over-intensities over larger surface. This effect has to be attributed to ionization processes with consequent laser beam refraction. Results show that Argon gas jet produces a strong refraction of the laser beam thus strongly reducing the initial two spots separation. (authors)

2009-08-01

219

Native Synthetic Imaging of Smoothed Particle Hydrodynamics density fields using gridless Monte Carlo Radiative Transfer

In this paper, numerical simulation of a concentric tube heat exchanger is presented to determine the convective heat transfer coefficient and friction factor in a smooth tube. Increasing the convective heat transfer coefficient can increase heat transfer rate in a concentric tube heat exchanger from a given tubular surface area. This can be achieved by using heat transfer augmentation devices. This work constitutes the initial phase of the numerical simulation of heat transfer from tubes employing augmentation devices, such as twisted tapes, wire-coil inserts, for heat transfer enhancement. A computational fluid dynamics (CFD) simulation tool was developed with CFX software and the results obtained from the simulations are validated with the empirical correlations for a smooth tube heat exchanger. The difficulties associated with the simulation of a heat exchanger augmented with wire-coil inserts are discussed. (author)

2003-05-28

220

Modeling and forecasting short-term interest rates: The benefits of smooth regimes, macroeconomic variables, and bagging

An algorithm for creating synthetic telescope images of Smoothed Particle Hydrodynamics (SPH) density fields is presented, which utilises the adaptive nature of the SPH formalism in full. The imaging process uses Monte Carlo Radiative Transfer (MCRT) methods to model the scattering and absorption of photon packets in the density field, which then exit the system and are captured on a pixelated image plane, creating a 2D image (or a 3D datacube, if the photons are also binned by their wavelength). The algorithm is implemented on the density field directly: no gridding of the field is required, allowing the density field to be described to an identical level of accuracy as the simulations that generated it. Some applications of the method to star and planet formation simulations are presented to illustrate the advantages of this new technique, and suggestions as to how this framework could support a Radiative Equilibrium algorithm are also given as an indication for ...

2010-01-01

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221

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Abstract In this paper we propose a smooth transition tree model for both the conditional mean and variance of the short-term interest rate process. The estimation of such models is addressed and the asymptotic properties of the quasi-maximum likelihood estimator are derived. Model specification is also discussed. When the model is applied to the US short-term interest rate we find: (1) leading indicators for inflation and real activity are the most relevant predictors in characterizing the multiple regimes' structure; (2) the optimal model has three limiting regimes. Moreover, we provide empirical evidence of the power of the model in forecasting the first two conditional moments when it is used in connection with bootstrap aggregation (bagging). Copyright 2010 John Wiley & Sons, Ltd.

2011-01-01

222

Irradiation effect of high current pulsed electron beam on surface structure and mechanical properties of NiCoCrAlY

Intravascular pressure augments cerebral arterial constriction by inducing voltage insensitive Ca2+ waves

DZ4 substrates were coated with NiCoCrAlY by plasma spray and subsequently treated by high current pulsed electron beams(HCPEB) of different parameters. The surface microstructure, phase structure and high temperature oxidation resistance were studied. It has been shown that as a result of the HCPEB treatment the loose and rough structure remelted and the surface became smooth. Smooth microregion, craters and cracks appeared on the surface. The ?' phase manifolded and there was no visible thermal stress. The oxidation test at 900 degree C for 100 h showed that a more compact and successive ?-Al_2O_3 scale was formed on the surface of the samples after HCPEB irradiation, which improved the oxidation resistance of the NiCoCrAlY coatings obviously. (authors)

2009-09-01

223

British Library Electronic Table of Contents (United Kingdom)

This study examined whether elevated intravascular pressure stimulates asynchronous Ca2+ waves in cerebral arterial smooth muscle cells and if their generation contributes to myogenic tone development. The endothelium was removed from rat cerebral arteries, which were then mounted in an arteriograph, pressurized (20 100 mmHg) and examined under a variety of experimental conditions. Diameter and membrane potential (VM) were monitored using conventional techniques; Ca2+ wave generation and myosin light chain (MLC20)/MYPT1 (myosin phosphatase targeting subunit) phosphorylation were assessed by confocal microscopy and Western blot analysis, respectively. Elevating intravascular pressure increased the proportion of smooth muscle cells firing asynchronous Ca2+ waves as well as event frequency. C...

2010-01-01

224

Effect of matrix strength on pullout behavior of steel fiber reinforced very-high strength concrete composites

British Library Electronic Table of Contents (United Kingdom)

This paper presents the results of single-fiber pullout tests for deformed and smooth steel fibers embedded in the newly developed very-high strength concrete (VHSC) matrixes. The pullout test program involved four types of steel fibers, eight compressive strengths of VHSC matrixes, and two normal concrete strengths. Test results have shown that pullout behavior of different steel fiber reinforced VHSC composites is influenced by the matrix strength and fiber end condition (smooth, flat end, or hooked). Results reveal that both maximum pull-out load and total pullout energy increases as matrix strength increases for all deformed fibers that did not rupture. The test results also indicated that the increase in total pullout energy is more significant than that in peak load.

2011-01-01

225

Analysis of mixing in a Twin Cam mixer using smoothed particle hydrodynamics

British Library Electronic Table of Contents (United Kingdom)

Smoothed Particle Hydrodynamics (SPH) is a Lagrangian, particle-based method that is well suited to industrial mixing simulations. Mass transport is simply the motion of the particles, and its grid-free nature means that it can easily accommodate complicated geometries involving moving parts and sharp corners. This article describes 2D SPH simulations of a Twin Cam mixer and compares the results against experimental data and results from two published finite element method (FEM) simulations. To analyze the mixing processes in the Twin Cam mixer, we present a method for calculating the Finite-Time Lyapunov Exponent (FTLE) using SPH particle data. The FTLEs can be used to locate the unstable and stable manifolds in the flow and indicate where mixing is either promoted or inhibited in the flo...

2008-01-01

226

Stent-assisted recanalization of atherosclerotic intracranial stenosis

MR imaging and MR cholangiopancreatography in the preoperative evaluation of hilar cholangiocarcinoma: correlation with surgical and pathologic findings

Intracranial atherosclerosis is a major cause of ischemic stroke, and depending on the studied population, it accounts for 8%-15% of all strokes that are due to cerebral atherosclerosis. The prognosis of patients with symptomatic intracranial stenoses seems to depend on the location and extent of intracranial atherosclerosis. Currently, the primary treatment in intracranial atherosclerosis is the control of vascular risk factors such as hypertension, diabetes, hypercholesterolemia, and smoking. Secondary prevention with antiplatelet therapy has been shown to reduce the risk of subsequent vascular events in patients who have suffered a recent ischemic stroke or transient ischemic attack (TIA). Unfortunately, a significant number of patients with intracranial atherosclerosis continue to suffer from repeated strokes or TIA despite maximal medical treatment. Although endovascular revascularization for symptomatic intracranial stenoses remains at ...

2006-09-01

227

Computed tomography (CT) in renal trauma

The primary aim was to evaluate delayed contrast-enhanced MRI in depicting perineural spread of hilar cholangiocarcinoma (CCC) and consequently to determine the capability of MRI/MRCP for staging CCC. Fifteen patients that underwent MRI/MRCP and surgical treatment were retrospectively included. Two radiologists evaluated MR images to assess delayed periductal enhancement, extent of bile duct stenosis, liver parenchymal and vascular involvement and presence of liver atrophy. An agreement between delayed enhancement of the bile duct walls and perineural neoplastic spread showed a very good correlation factor (0.93). The overall accuracy in detecting biliary neoplastic invasion was higher for delayed T1-weighted images (93.3%) than for the MRCP images (80%), and T1-delayed image increased the MR accuracy in assessing the neoplastic resectability (p < 0.05). MRI correctly predicted vascular involvement in 73% and liver involvement in 80% of the ...

2008-10-01

228

Blunt renal trauma in children: healing of renal injuries and recommendations for imaging follow-up

CT scans were performed on 25 patients suspected of sustaining ranal trauma. The utility of CT in both detecting renal damage and appraising the gravity of injuries was assessed. Nowadays, in fact, nephrectomy or reserved for lesions devastanting the kidney parenchyma or rupturing the renal pedicle; so it is very important to identyfy both the purposes of a better planned therapeutic approach. CT does both, being more accurate than urography in the detection of renal fractures, intra or extraparenchymal hematomas and contrast media extravasation. Urography very often shows aspecific lesion patterns and sometimes it is also falsely negative. In the present series CT was more reliable than angiography itself, particulary in the diagnosis of extra-renal hematic collections, contrast media extravasation and injuries to the other abdominal organs. Although CT may arouse the suspicion of and sometimes correctly diagnose vascular lesions, such as renal infarction, ...

1987-01-01

229

Bevacizumab as a treatment option for radiation-induced cerebral necrosis

Initial CT grading of renal injury was correlated with the frequency of complications and the time course of healing in 35 children. All renal contusions (grade 1, 8) and small parenchymal lacerations (grade 2, 8) healed without complications. All lacerations extending to the collecting system (grade 3, 9) resulted in mild to severe loss of renal function with progressive healing over 4 months. One of four segmental infarcts (grade 4 A), and five of six vascular pedicle injuries (grade 4 B) resulted in severe loss of renal function. Complications, including urinoma (2), sepsis (1), hydronephrosis (1), and persistent hypertension (2), were limited to grade 3 and 4 injuries. Our results suggest that mild renal injuries do not require follow-up imaging. Major renal lacerations and vascular pedicle injuries, however, often result in loss of renal function and should be followed up closely due to the risk of delayed complications. Follow-up ...

230

Angiogenic cytokines and growth factors in systemic sclerosis.

Radiation necrosis of normal CNS tissue represents one of the main risk factors of brain irradiation, occurring more frequently and earlier at higher total doses and higher doses per fraction. At present, it is believed that the necrosis results due to increasing capillary permeability caused by cytokine release leading to extracellular edema. This process is sustained by endothelial dysfunction, tissue hypoxia, and subsequent necrosis. Consequently, blocking the vascular endothelial growth factor (VEGF) at an early stage could be an option to reduce the development of radiation necrosis by decreasing the vascular permeability. This might help to reverse the pathological mechanisms, improve the symptoms and prevent further progression. A patient with radiation-induced necrosis was treated with an anti-VEGF antibody (bevacizumab), in whom neurologic signs and symptoms improved in accordance with a decrease in T1-weighted fluid-attenuated ...

2011-02-01

231

Studies on the chemical composition and possible mechanisms underlying the antispasmodic and bronchodilatory activities of the essential oil of Artemisia maritima L.

Systemic sclerosis is an autoimmune connective tissue disorder characterized by a widespread microangiopathy, autoimmunity and fibrosis of the skin and of various internal organs. Microangiopathy is characterized by a reduced capillary density and an irregular chaotic architecture that lead to chronic tissue hypoxia. Despite the hypoxic conditions, there is no evidence for a sufficient compensative angiogenesis in SSc. Furthermore, vasculogenesis is also impaired. An imbalance between angiogenic and angiostatic factors might explain the pathogenetic mechanisms of SSc vasculopathy. As far as angiogenic factors are concerned, within the most important are vascular endothelial growth factor (VEGF) and its receptors, platelet derived growth factor (PDGF), transforming growth factor beta (TGF-?), fibroblast growth factor -2 (FGF-2), angiopoietin 1 (Ang-1), stromal cell-derived factor 1 (SDF-1/CXCL12), endothelin-1 (ET-1), monocyte chemoattractant protein -1 (MCP-1), ...

2011-04-28

232

British Library Electronic Table of Contents (United Kingdom)

This study describes the chemical composition of the essential oil of Artemisia maritima (Am.Oil) and the pharmacological basis for its medicinal use in gut and airways disorders. Twenty five compounds, composing 93.7% of the oil, were identified; among these, chrysanthenyl propionate and elixene were identified for the first time from any Artemisia species. The Am.Oil (0.3?1.0 mg/mL) suppressed spontaneous and high K+ (80 mM)-induced contractions in isolated rabbit jejunum, suggestive of an antispasmodic effect mediated possibly through calcium channel blockade. The calcium channel blockade activity was confirmed when pre-treatment of the tissue with Am.Oil (0.01?0.03 mg/mL) shifted the Ca++ concentration-response curves to the right, similar to verapamil and papaverine. In isolated trach...

2011-01-01

233

Preparation and dosimetry of radiotherapeutic particles for arthropaties; Preparacion y dosimetria de particulas radioterapeuticas para artropatias

Prediction and measurement of the neutron environment in OSURR experimental facilities following conversion to LEU

It was developed a new formulation of macro aggregates of Samarium 153 ({sup 153} Sm-MH) for the arthropaties treatment. The radio pharmaceutic was prepared by reaction of Samarium 153 chloride (SmCl{sub 3}) in aqueous environment with sodium boron hydride in NaOH 0.5 N. The microscopic analysis shown that the particles have an average size of 4% m (range 1-14 {mu} m). The velocity of sedimentation was 0.008 cm/min with high stability in vitro in human serum. The biological studies in healthy rabbits, shown that the complex is retained inside the articulation still eight days after of the administration of the radiopharmaceutical. Likewise, it is presented the data of absorbed dose in the different target organs, which was determined by thermoluminescent dosimetry (TLD) through the use of a REMCAL phantom (radiation equivalent manikin calibration). (Author)

1999-07-01

234

Electrophysiological mechanisms of sophocarpine as a potential antiarrhythmic agent

Neutron energy spectra were measured for two OSURR experimental facilities. The method of multiple foil activation was used with the SAND-II neutron spectrum unfolding code to obtain spectral data for the Central Irradiation Facility and Rabbit tube. Limited data was obtained for the thermal column using only gold foils. Calculations were made of the neutron environment in various locations using the MORSE code. A shift towards higher neutron energies was observed comparing results for LEU and HEU cores. A slight loss in total thermal neutron flux was measured for all positions. Calculational results show reasonable agreement with measured data.

1993-07-01

235

British Library Electronic Table of Contents (United Kingdom)

Aim:To examine the electrophysiological effects of sophocarpine on action potentials (AP) and ionic currents of cardiac myocytes and to compare some of these effects with those of amiodarone.Methods:Langendorff perfusion set-up was used in isolated guinea pig heart, and responses to sophocarpine were monitored using electrocardiograph. Conventional microelectrode, voltage clamp technique and perforated patch were employed to record fast response AP (fAP), slow response AP (sAP) and ionic currents in guinea pig papillary muscle or rabbit sinus node cells.Results:Tachyarrhythmia produced by isoprenaline (15 ?mol/L) could be reversed by sophocarpine (300 ?mol/L). Sophocarpine (10 ?mol/L) decreased the amplitude by 4.0%, maximal depolarization velocity (Vmax) of the fAP by 24.4%...

2011-01-01

236

Characterization of the platelet-aggregating activity of tumor cells. [Mice

Annual report of JMTR, 1994. April 1, 1994 - March 31, 1995

Two lines of mouse tumor cells were shown to be capable of aggregating mouse and rabbit platelets in vitro. This process required higher Mg/sup 2 +/ concentrations than were needed by other commonly used platelet-aggregating agents. Platelet-aggregating activity was also found in tumor cell membrane fragments. This membrane-bound platelet-aggregating material contained protein, lipid, and carbohydrate moieties. The presence of all three appeared to be essential for stimulating platelet aggregation. Destruction of any component abolished its activity. Platelet aggregation induced by tumor cell membrane fragments was associated with a secretory release reaction. In this process, growth-promoting activity for tumor cells was also released from platelets. These results underline the importance of platelets in establishing tumor metastases.

1980-04-01

237

Amino acid substitution: its use in detection and analysis of genetic variants

In FY1994, JMTR was in operation during 4 operation cycles with low enriched Uranium(LEU,20%) fuel for irradiation study of nuclear fuels and materials and for radioisotope production. Irradiation studies were carried out using capsules, Oarai Gas Loop-1(OGL-1), Oarai Shroud Facility(OSF-1) and hydraulic rabbits irradiation facilities in support of LWR, FBR, HTTR and thermonuclear reactor. Irradiation studies on blanket materials were intensively carried out. Power ramping tests were carried out and the future program is under consideration. For R and D works, neutron spectrum evaluation technology, re-instrumentation technique for irradiation fuel rod, remote controlled SEM apparatus and examination technique with miniaturized specimens were successfully developed. (author).

1996-03-01

238

Aldehyde dehydrogenase (ALDH) 3A1 expression by the human keratocyte and its repair phenotypes

Techniques of chemical analysis, amino acid sequencing and autoradiography are being used to study the frequency of incorporation of normally noncoded amino acids into hemoglobins and seminal fluid proteins. We are studying, by the sequencing of radiolabeled proteins followed by the recovery of ["3H] isoleucine phenylthiohydantoin by high-performance liquid chromatography, the frequency at which normally noncoded isoleucine is incorporated into hemoglobin because of base-substitution mutations versus translational errors. Irradiation increases the isoleucine content of human hemoglobin and the frequency of substitution of isoleucine for specific amino acids in rabbit hemoglobin. Studies to date indicate that these techniques have been developed sufficiently for initial analysis of the potential of drugs and environmental pollutants to induce base-substitution mutations in mammalian somatic cells.

239

British Library Electronic Table of Contents (United Kingdom)

Transparency is essential for normal corneal function. Recent studies suggest that corneal cells express high levels of so-called corneal crystallins, such as aldehyde dehydrogenase (ALDH) and transketolase (TKT) that contribute to maintaining cellular transparency. Stromal injury leads to the appearance of repair phenotype keratocytes, the corneal fibroblast and myofibroblast. Previous studies on keratocytes from species such as bovine and rabbit indicate that the transformation from the normal to repair phenotype is accompanied by a loss of corneal crystallin expression, which may be associated with loss of cellular transparency. Here we investigated if a similar loss occurs with human keratocyte repair phenotypes. Human corneal epithelial cells were collected by scraping and keratocytes...

2006-01-01

240

The role of interventional radiology in management of patients with end-stage renal disease

Probable role of trace elements of some medicinal plants in cardio-vascular diseases

The aim of the paper is to review the role of interventional radiology in the management of hemodialysis vascular access and complications in renal transplantation. The evaluation of patients with hemodialysis vascular access is complex. It includes the radiology/ultrasound (US) evaluation of the peripheral veins of the upper extremities with venous mapping and the evaluation of the central vein prior to the access placement and radiological detection and treatment of the stenosis and thrombosis in misfunctional dialysis fistulas. Preoperative screening enables the identification of a suitable vessel to create a hemodynamically-sound dialysis fistula. Clinical and radiological detection of the hemodynamically significant stenosis or occlusion demands fistulography and endovascular treatment. Endovascular prophylactic dilatation of stenosis greater than 50% with associated clinical abnormalities such as flow-rate reduction is warranted to ...

2003-05-01

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241

Posttraumatic tibia valga: a case demonstrating asymmetric activity at the proximal growth plate on technetium bone scan

A number of herbal drugs are used in the Unani (Greco-Arab) System of Medicine for cardiovascular diseases. The herbs were analyzed by flame AAS and ICP-AES to determine if their therapeutic actions can be associated with the elements present in them. Cadmium, cobalt, chromium, copper, iron, potassium, magnesium, manganese, sodium, nickel, phosphorus, lead and zinc were some of the elements which play various roles in cardiovascular affections. An effort was made to correlate the role of these elements in cardiac diseases. (Auth.). 2 tabs., 32 refs.

242

Posttraumatic tibia valga: a case demonstrating asymmetric activity at the proximal growth plate on technetium bone scan

Posttraumatic tibia valga is a well-recognized complication following fracture of the upper tibial metaphysis in young children. We present a case of a child who developed a valgus deformity following fracture of the proximal tibia and fibula in which quantitative bone scintigraphy at 5 months after injury demonstrated increased uptake at the proximal tibial growth plate with proportionally greater uptake on the medial side. This finding suggests that the valgus deformity in this patient was due to a relative increase in vascularity and consequent overgrowth of the medial portion of the proximal tibial physis.

1987-07-01

243

Avascular necrosis associated with nailing of femoral neck fracture

Posttraumatic tibia valga is a well-recognized complication following fracture of the upper tibial metaphysis in young children. We present a case of a child who developed a valgus deformity following fracture of the proximal tibia and fibula in which quantitative bone scintigraphy at 5 months after injury demonstrated increased uptake at the proximal tibial growth plate with proportionally greater uptake on the medial side. This finding suggests that the valgus deformity in this patient was due to a relative increase in vascularity and consequent overgrowth of the medial portion of the proximal tibial physis.

244

Avascular necrosis associated with nailing of femoral neck fracture

Two patients with femoral neck fractures, one displaced and one undisplaced, are presented. Preoperative intravital staining with tetracycline and Tc-MDP scintimetry both showed intact femoral head circulation while Tc-MDP-scintimetry 1 week after operation showed pronounced circulatory deficiency. Sr/sup 85/-scintimetry performed at the same time was inconclusive. Segmental collapse was observed radiographically, 8 and 12 months postoperatively. The major vascular injury resulting in avascularity most probably occured during the procedure of osteosynthesis, and Tc-MDP-scintimetry was found suitable for early postoperative recognition of avascular necrosis in both fractures.

1983-01-01

245

Utilization of smooth models for seismic data tomographic inversion

Two patients with femoral neck fractures, one displaced and one undisplaced, are presented. Preoperative intravital staining with tetracycline and Tc-MDP scintimetry both showed intact femoral head circulation while Tc-MDP-scintimetry 1 week after operation showed pronounced circulatory deficiency. SR"8"5-scintimetry performed at the same time was inconclusive. Segmental collapse was observed radiographically, 8 and 12 months postoperatively. The major vascular injury resulting in avascularity most probably occured during the procedure of osteosynthesis, and Tc-MDP-scintimetry was found suitable for early postoperative recognition of avascular necrosis in both fractures. (author).

246

Optimal Knot Selection for Least-squares Fitting of Noisy Data with Spline Functions

Reflection tomography allows in theory the determination of the velocity distribution and the reflector geometries in the subsurface from the travel times of the seismic waves. The solution of the inverse problem is the model (velocity distribution and reflectors) that minimizes the misfits between observed travel times and travel times computed by raytracing (the forward problem). Two representations of the velocity field are generally used: blocky models (discontinuous) and smooth models. The object of this thesis is the study of tomography with smooth models which offer interesting properties at a practical level as well as at a mathematical and numerical level. We propose an original formulation of the inverse problem which allow the integration of a priori information adapted to smooth models. This formulation assures the existence, the uniqueness and the stability of the solution of the linearized inverse problem. The ...

1995-03-01

247

On-line replacement of a particle accelerator control computer

An automatic data-smoothing algorithm for data from digital oscilloscopes is described. The algorithm adjusts the bandwidth of the filtering as a function of time to provide minimum mean squared error at each time. It produces an estimate of the root-mean-square error as a function of time and does so without any statistical assumptions about the unknown signal. The algorithm is based on least-squares fitting to the data of cubic spline functions.

2008-05-15

248

On a canonical class of Green currents for the unit sections of abelian schemes

This paper describes the conversion from an existing production control computer, an SEL 840, to a DEC VAX 11/780. The plan is to add a layer of hardware to accomplish a smooth and gradual transition from the 840 to the VAX while leaving the underlying equipment unchanged. The architecture of the control system software is discussed for a large linear accelerator from the standpoint of its requirements and the particular design philosophy chosen.

1981-01-01

249

Merged Sounding Value-Added Product

We show that on any abelian scheme over a complex quasi-projective smooth variety, there is a Green current for the zero-section, which is axiomatically determined up to $\\partial$ and $\\bar\\partial$-exact differential forms. This current generalizes the Siegel functions defined on elliptic curves. We prove generalizations of classical properties of Siegel functions, like distribution relations, limit formulae and reciprocity laws.

2011-01-01

250

Advancing Age Alters the Contribution of Calcium Release From Smooth Endoplasmic Reticulum Stores in Superior Cervical Ganglion Cells

The Merged Sounding value-added product (VAP) uses a combination of observations from radiosonde soundings, the microwave radiometer (MWR), surface meteorological instruments, and European Centre for Medium-Range Weather Forecasts (ECMWF) model output with a sophisticated scaling/interpolation/smoothing scheme in order to define profiles of the atmospheric thermodynamic state at one-minute temporal intervals and a total of 266 altitude levels.

2010-03-03

251

A High-Wavenumber Viscosity for High-Resolution Numerical Methods

In superior cervical ganglion (SCG) neurons calcium-induced calcium release (CICR), mediated by ryanodine receptors (RyRs), contributes to stimulation-evoked intracellular calcium ([Ca²⁺]_i)...Full Text Available

2009-01-01

252

Pioglitazone does not affect vascular or inflammatory responses after endotoxemia in humans.

Numerical simulations of compressible flows are commonly based on the Euler equations when effects of viscosity are thought to be negligible. These equations admit singular solutions, even in cases where the initial and boundary conditions are smooth. So-called ''Euler solvers'' rely on numerical dissipation, explicitly or implicitly present in the scheme, to regularize the problem, such that physical solutions are selected.

2003-02-19

253

Patterns of proliferation related to vasculature in human head-and-neck carcinomas before and after transplantation in nude mice

PPARgamma agonists have been proposed to exert more than metabolic benefits, particularly by anti-inflammatory mechanisms. We hypothesized that pioglitazone might modulate inflammatory and vascular responses to lipopolysaccharide (LPS). In a placebo-controlled parallel-group study in 18 healthy male subjects, the E. coli endotoxin model of inflammation (20 IU/kg i. v.) was employed to test the effect of 60 mg pioglitazone over nine days on inflammatory cytokines. Macrovascular function and microvascular blood flow were assessed by brachial artery ultrasound and retinal blood flow parameters, respectively. Pioglitazone increased brachial artery diameter by 5.6% but had no effect on other outcome parameters under resting conditions. LPS increased cytokine levels to peak concentrations of 91.3+/-22.5 ng/ml (IL-6), 261.4+/-60.0 ng/ml (TNFalpha), and 524.5+/-15.3 ng/ml (VCAM-1). The endotoxin caused microvascular vasodilation and increased retinal white blood cell flux, ...

2008-05-21

254

The effect of oxygen and paraquat on the "1"4C-glucose oxidation of rabbit alveolar macrophages and lung slices

Purpose: The predictive potential of tumor cell kinetic parameters may be improved when they are studied in relation to other microenvironmental parameters. The purpose of this investigation was to quantitatively categorize human tumor samples according to proliferation patterns. Second, it was examined whether these characteristics are retained after xenotransplantation. Methods and Materials: Fifty tumor samples from head-and-neck cancer patients were immunohistochemically stained for Ki-67 and vessels. Also, parts of the samples were transplanted into nude mice. Tumors were categorized according to previously described patterns of proliferation. Vascular and proliferation patterns were analyzed using an image processing system. Results: The 50 tumors were categorized into four patterns of proliferation by visual assessment: marginal (6), intermediate (10), random (21), and mixed (12). One tumor could not be classified. These patterns were quantified by ...

2001-12-01

255

Serine-324 of myosin's heavy chain is photoaffinity-labeled by 3 prime (2 prime )-O-(4-benzoylbenzoyl)adenosine triphosphate

In this study, we measured the effects of different concentrations of paraquat (0,01 mM and 1,0 mM) on the 1-"1"4CO_2 and 6-"1"4CO_2 production of rabbit lung slices and isolated alveolar macrophages, in 20% and 95% oxygen phases respectively. A 95% oxygen phase induced an increase in the 6-"1"4C-glucose oxidation of control lung slices over a 3-hour period, while the increased activity of the pentose pathway over the first 2 hours started to decline during the third hour of incubation. Paraquat (1,0mM) in 20% oxygen caused a consistent increase in the 6-"1"4CO_2 production by lung slices, but in a 95% oxygen phase gradually inhibited the 6-"1"4C-glucose oxidation over a period of 3 hours. The pentose phosphate pathway was highly significantly stimulated by 1,0 mM paraquat in 20% and 95% oxygen over 3 hours. When isolated alveolar macrophages (viability 95%) were incubated in a 20% and 95% oxygen phase respectively, both the 6-"1"4C-glucose and 1-"1"4C-glucose ...

256

Platelet receptor recognition domain on the. gamma. chain of human fibrinogen and its synthetic peptide analogues

A portion of the active site of rabbit skeletal myosin near the ribose ring of ATP can be labeled by the photoaffinity analogue 3{prime}(2{prime})-O-(4-benzoylbenzoyl)adenosine triphosphate (Bz{sub 2}ATP). The specificity of the photolabeling was assured by first trapping ({sup 14}C)Bz{sub 2}ATP at the active site by use of thiol cross-linking agents. Five radioactive peptides were isolated by high-performance liquid chromatography after extensive trypsin and subtilisin digestion of photolabeled myosin subfragment 1. Four of these peptides were sequenced by Edman techniques, and all originated from a region with the sequence Gly-Glu-Ile-Thr-Val-Pro-Ser-Ile-Asp-Asp-Gln, which corresponds to rabbit myosin heavy chain residues 312-328. The fifth labeled peptide had an amino acid composition appropriate for residues 312-328. Amino acid composition, radiochemical analysis, and sequence data indicate that Ser-324 is the major amino acid residue ...

1989-05-02

257

Mechanism of sup(99m)Tc-methylene diphosphonate (sup(99m)Tc-MDP) localization in experimental studies of bone tumors. Microautoradiography method

The authors have shown previously that the domain recognizing receptors on activated human platelets is located on the human fibrinogen {gamma} chain between residues 400 and 411. To study the correlation between the structure of this segment of the {gamma} chain and its reactivity toward receptors on ADP-activated human platelets, they designed a series of analogues containing replacements at 9 out of 12 positions. A double substitution of the normal His{sup 400}-His{sup 401} sequence by Ala-Ala reduced the inhibitory potency of the dodecapeptide 3-fold. When Lys{sup 406} was replaced by Arg, the inhibitory potency of the dodecapeptide decreased 15 times. On the other hand, substitution of Ala{sup 408} with Arg increased the inhibitory potency of the dodecapeptide 6-fold. A drastic decrease in the reactivity of the dodecapeptide toward platelet receptors was observed when Val{sup 411} was replaced by leucine or cysteine or tyrosine. A 3-fold decrease in reactivity was noted when ...

1989-04-04

258

Mechanism of sup(99m)Tc-methylene diphosphonate (Tc-MDP) localization in clinical and experimental studies of bone tumors

(Materials and Methods) (I) VX/sub 2/ carcinoma was transplanted to the rabbit tibia, sup(99m)Tc-MDP was intravenously injected when bone destruction was radiologically seen. Preoperative scintigraphs, postoperative one of the resected tibia and fibra and scintigraphs of sliced tumor were compared with each other. Tissue fragments were collected from the sliced tumor, and RI was measured to compare concentration rates at different parts together with histological investigations. (II) Tetracycline was given to the rabbit of Experiment (I) to compare with the concentration of sup(99m)Tc-MDP. (III) Microautoradiography method was done on the experimental animals for investigation of the concentration of sup(99m)Tc-MDP. (Results) (I) Localization of sup(99m)Tc-MDP was increased at the sites of tumorous bone formation, of reactive bone formation at tumor edges, and of cartilage calcification, with little concentration at tumor cells or necrotic ...

1981-12-01

259

Effects of holmium laser on dental structure in vivo: thermal evaluation and histological analysis on pulpal tissue; Efeitos in vivo do laser de holmio em estrutura dental: monitoracao termica e analise histologica do tecido pulpar

Tc-MDP 10mCi was intravenously given preoperatively to 20 patients with primary bone tumors and 1 with a metastatic bone tumor. Preoperative and postoperative scintigraphs of resected tumor and scintigraphs of sliced tumor were compared. Tissue fragments were collected from the sliced tumor, and RI measured to compare concentration rates at different areas. Histological investigations were also done. Localization of Tc-MDP was increased at sites of tumorous bone formation, of reactive bone formation at tumor edges, and of cartilage calcification, with little concentration at tumor cells or necrotic tissue. VX/sub 2/ carcinoma was transplanted into the rabbit tibia, Tc-MDP was intravenously injected when bone destruction was radiologically evident, and investigations were done as in the clinical cases. In experimental bone tumor, increased uptake localization of Tc-MDP was much the same as in clinical cases. Tetracycline was given to the rabbit ...

1981-06-01

260

Cysteinyl peptides of rabbit muscle pyruvate kinase labeled by the affinity label 8-((4-bromo-2,3-dioxobutyl)thio)adenosine 5 prime -triphosphate

Previous in vitro studies have demonstrated that Ho:YLF laser is capable of inducing physical and chemical changes on dental surfaces treated for caries prevention. The temperature in the pulp chamber was in vitro evaluated to as a function of the power and frequency of the laser irradiation. The purpose of this work is to verify the occurrence of pulp inflammation after Ho:YLF laser irradiation using different parameters in rabbits' teeth. The premolars and molars of ten rabbits (NZB) were divided in two groups according to the irradiation energy values of a Ho:YLF laser prototype operating at 2.065{mu}m wave length, frequency of O,5Hz and pulse length of 250{mu}s. An group A teeth were irradiated with using ten pulses of 334mJ/pulse of a Ho:YLF laser prototype operating at O.5Hz, and group B, with 512mJ/pulse. Animals were killed by transcardiac perfusion and the samples were prepared for histopathological analysis. The in vitro ...

2001-07-01

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261

Analysis of Elements in The Baltic Sea Sediment by Using Gamma Spectrometry

The affinity label 8-((4-bromo-2,3-dioxobutyl)thio)adenosine 5{prime}-triphosphate (8-BDB-TA-5{prime}-TP) reacts covalently with rabbit muscle pyruvate kinase, incorporating 2 mol of reagent/mol of enzyme subunit upon complete inactivation. Protection against inactivation is provided by phosphoenolpyruvate, K{sup +}, and Mn{sup 2+} and only 1 mol of reagent/mol of subunit is incorporated. The authors have now identified the resultant modified residues. After reaction with 8-BDB-TA-5{prime}-TP at pH 7.0, modified enzyme was incubated with ({sup 3}H)NaBH{sub 4} to reduce the carbonyl groups of enzyme-bound 8-BDB-TA-5{prime}-TP and to introduce a radioactive tracer into the modified residues. Following carboxymethylation and digestion with trypsin, the radioactive peptides were separated on a phenylboronate agarose column followed by reverse-phase high-performance liquid chromatography in 0.1% trifluoroacetic acid with an acetonitrile gradient. Gas-phase sequencing ...

1990-03-13

262

Smooth muscle myosin heavy chain locus (MYH11) maps to 16p13. 13-p13. 12 and establishes a new region of conserved synteny between human 16p and mouse 16

We have done analysis of elements in the Baltic sea sediment by using gamma spectrometry in neutron activation analysis Goal of the analysis is to determine the rate of morsel elements which is contained in the Baltic sea sediment. Sample of the Baltic sea Sediment (IAEA-SED-1), Standard of Reference Material (SRM) 1646 Estuarine Sediment and Standard Ce, Fe, Sc, and Co are put into vial of capsule rabbit, then irradiated together for 30 minutes in rabbit facility Multi Purpose Reactor at power of 25 MW and then cooled for one week. Next sample, standard, and SRM which have irradiated, each is cut for 30 minutes using gamma spectrometer. Result of analysis of rate of elements Ce, Fe, Sc and Co in the baltic sea sediment successively equal to 141.20 ppm, 5.91 %, 14.88 ppm, and 19.59 ppm. Result of analysis in SRM Estuarine sediment successively equal to 96.60 ppm, 3.21 %, 10.25 ppm, and 9.63 ppm. Result of this analysis if compared to the value ...

2007-04-01

263

SZ effects from annihilating dark matter in the Milky Way: smooth halo, subhalos and intermediate-mass-black-holes

The human smooth muscle myosin heavy chain locus (MYH11) was mapped by fluorescence in situ hybridization to the middle of the p arm of chromosome 16 using a genomic cosmid clone containing coding sequences of the gene as probe. Probe from coding sequence, when applied to Southern blots of a panel of hybrids containing different portions of human chromosome 16, localized the gene to 16p13.13-13.12. Coding sequence PCR primers, when used on the DNA from a CHO-mouse hybrid clone mapping panel informative for mouse chromosomes, showed that the gene was located on mouse chromosome 16. These results correct a recent assignment of MYH11 from 16q12.2 to the region of the 16p-arm inversion breakpoint seen in acute myelomonocytic leukemia (AMML) M4Eo and demonstrate that the conflicting data do not result from the presence of additional MYH genes on the q arm of the chromosome. Also, a new region of conserved synteny between human 16p and mouse 16 is established. 10 refs., ...

1993-10-01

264

Prediction of refrigerant void fraction in horizontal tubes using probabilistic flow regime maps

We study the Sunyaev-Zel'dovich (SZ) effect potentially generated by relativistic electrons injected from dark matter (DM) annihilation or decay in the Galaxy, and check whether it could be observed by Planck or ALMA, or even imprint the current CMB data as e.g. the specific fluctuation excess claimed from an recent re-analysis of the WMAP-5 data. We focus on high-latitude regions to avoid contamination of the Galactic astrophysical electron foreground, and consider the annihilation or decay coming from the smooth DM halo as well as from subhalos, further extending our analysis to a generic modeling of spikes arising around intermediate-mass-black-holes (IMBHs). We show that all these dark Galactic components are unlikely to produce any observable SZ effect. For a self-annihilating DM particle of 10 GeV with canonical properties, the largest optical depth we find is $\\tau_e \\lesssim 10^{-7}$ for massive isolated subhalos hosting IMBHs. We conclude that dark ...

2010-01-01

265

Prediction of fatigue crack growth behaviour of an #alpha#-#beta# titanium alloy in Paris-regime using LCF properties

A state of the art review of two-phase void fraction models in smooth horizontal tubes is provided and a probabilistic two-phase flow regime map void fraction model is developed for refrigerants under condensation, adiabatic, and evaporation conditions in smooth, horizontal tubes. Time fraction information from a generalized probabilistic two-phase flow map is used to provide a physically based weighting of void fraction models for different flow regimes. The present model and void fraction models in the literature are compared to data from multiple sources including R11, R12, R134a, R22, R410A refrigerants, 4.26-9.58 mm diameter tubes, mass fluxes from 70 to 900 kg/m{sup 2} s, and a full quality range. The present model has a mean absolute deviation of 3.5% when compared to the collected database. (author)

2008-04-15

266

Partial Isometries of a Sub-Riemannian Manifold

A model has been developed in the recent past to predict fatigue crack growth (FCG) behaviour in the Paris-regime of various steels by employing low cycle fatigue (LCF) properties. The model forms its basis on the assumption that the cyclic damage process immediately ahead of a crack-tip, restricted in a small zone termed as process zone, is identical to those experienced in the LCF loading of a smooth specimen. Within the process zone, fatigue damage has been assumed in terms of product of stress and plastic strain which is analogous to the plastic strain energy density of the smooth specimen under fatigue loading. In this paper the model developed by Kujawski and Ellyin has been used to predict the FCG behaviour of an #alpha#-#beta# titanium alloy in the Paris-regime by employing the experimentally obtained LCF properties. The FCG behaviour thus theoretically predicted was compared with the experimentally determined FCG behaviour.

267

High-efficiency RF suppression circuit for fluorescent lamp inverters using charge pump and partial smoothinf capacitors; Chagi ponpu shiki korikiritsu bubun heikatsu hoshiki wo mochiita keikoto inbatayo kochoha teigen kairo

In this paper, we obtain the following generalisation of isometric $C^1$-immersion theorem of Nash and Kuiper. Let $M$ be a smooth manifold of dimension $m$ and $H$ a rank $k$ subbundle of the tangent bundle $TM$ with a Riemannian metric $g_H$. Then the pair $(H,g_H)$ defines a sub-Riemannian structure on $M$. We call a $C^1$-map $f:(M,H,g_H)\\to (N,h)$ into a Riemannian manifold $(N,h)$ a {\\em partial isometry} if the derivative map $df$ restricted to $H$ is isometric; in other words, $f^*h|_H=g_H$. The main result states that if $\\dim N>k$ then a smooth $H$-immersion $f_0:M\\to N$ satisfying $f^*h|_H

2010-01-01

268

Heat transfer augmentation in 3D internally finned and microfinned helical tube

A highly efficiency partial smoothing method is proposed to be used for inverters for 40W class household fluorescent inverters. In this system, the input current from the commercial AC power source is accumulated in a capacitor with comparatively small capacity as the electric charge, and then the lamp circuit is driven by the inverter utilizing the charging voltage of the capacitor and the charging voltage of the separately prepared partial smoothing capacitor. By this method, the RF harmonic components in the supply current can be decreased to improve the power factor with no complicated feedback controlling device. In addition, comparatively small capacity coils and capacitors can be used. The structure of the circuit and the operation of this proposed method are described, and the operational characteristic of the prototype circuit and the result of analysis are shown. Furthermore, problems and improving method of the actual circuit are ...

1997-06-20

269

Gelatin ablation wavelength dependency in the range of 5.6-6.7 #mu#m using a mid-infrared Free Electron Laser

Experiments are performed to investigate the single-phase flow and flow-boiling heat transfer augmentation in 3D internally finned and micro-finned helical tubes. The tests for single-phase flow heat transfer augmentation are carried out in helical tubes with a curvature of 0.0663 and a length of 1.15 m, and the examined range of the Reynolds number varies from 1000 to 8500. Within the applied range of Reynolds number, compared with the smooth helical tube, the average heat transfer augmentation ratio for the two finned tubes is 71% and 103%, but associated with a flow resistance increase of 90% and 140%, respectively. A higher fin height gives a higher heat transfer rate and a larger friction flow resistance. The tests for flow-boiling heat transfer are carried out in 3D internally micro-finned helical tube with a curvature of 0.0605 and a length of 0.668 m. Compared with that in the smooth helical tube, the boiling heat transfer coefficient ...

2005-05-01

270

Corrosion behaviour of molybdenum-implanted stainless steel

Efficient and precise ablation of soft tissue is needed for non-invasive dermatological and corneal surgeries. Previous research has revealed that smooth and efficient cutting of certain soft tissues and gelatin is possible using a Free Electron Laser (FEL) with a wavelength of #lambda#=6.45 #mu#m, tuned to the amide-II band of protein. Gelatin ablation experiments have been carried out using a mid-infrared FEL within the waveband #lambda#=5.6-6.7 #mu#m by changing the primary absorbers such as water (#lambda#=6.1 #mu#m) and protein (#lambda#=6.45 #mu#m). The gelatin with 80 wt% water was efficiently ablated by FEL irradiation with the waveband #lambda#=#approx#5.95-6.19 #mu#m. On the other hand, using irradiation within #lambda#=#approx#6.4-6.6 #mu#m, many small bubbles were observed in the irradiated volume, and the gelatin was not ablated but significantly melted. Thus, it was found that the most effective wavelength was #approx#6.1 #mu#m, not #approx#6.45 ...

2003-07-11

271

Corrosion behaviour of molybdenum-implanted stainless steel

A low-molybdenum austenitic stainless steel (UNS S30100) has been surface implanted with molybdenum ions, using various doses of 50 keV and 140 keV ions at room temperature. It is found that in aqueous sulphate/chloride solutions similar to the constitution of sea-waters the implantation does not affect the potentiostatically-determined critical pitting potential, but does change the density and morphology of corrosion pits. Pitting initiation after the addition of chloride at a fixed potential indicates little change in the time for measurable current increase, but the rate of increase of the current is much lower for implanted material. Detailed examination using optical microscopy, scanning electron microscopy, transmission electron microscopy and selected area diffraction suggests that the pits produced in implanted material are hemispherical with smooth covers of unattacked alloy. The use of half-implanted samples demonstrates that molybdenum implantation ...

1990-01-01

272

Contributions to the Analysis of Spatial and Spatial-Temporal Data

A low-molybdenum austenitic stainless steel (UNS S30100) has been surface implanted with molybdenum ions, using various doses of 50 keV and 140 keV ions at room temperature. It is found that in aqueous sulphate/chloride solutions similar to the constitution of sea-waters the implantation does not affect the potentiostatically-determined critical pitting potential, but does change the density and morphology of corrosion pits. Pitting initiation after the addition of chloride at a fixed potential indicates little change in the time for measurable current increase, but the rate of increase of the current is much lower for implanted material. Detailed examination using optical microscopy, scanning electron microscopy, transmission electron microscopy and selected area diffraction suggests that the pits produced in implanted material are hemispherical with smooth covers of unattacked alloy. The use of half-implanted samples demonstrates that molybdenum implantation ...

1989-09-01

273

AP Theory IV: Intrinsic Topological Quantum Langlands Theory

This doctoral thesis addresses some problems in the analysis of spatial and spatial-temporal data and discusses prediction, prediction errors and identification of emission sources. European sulphur data are used as illustration. In an investigation of a spatial-temporal decomposition model for improving estimates of spatial interpolation (prediction) errors from monitoring data, the estimates were improved compared to estimates obtained by the method known as Kriging (an extension of the Wiener-Kolmogorov theory from time series to spatial processes), although the interpolated values were quite similar. A study of a random process model with an unknown, slowly varying trend and a correlated residual process is performed, using both trend estimation (smoothing) and prediction. Local polynomial methods are extended to continuous random processes. A new approach to non-parametric smoothing and to non-parametric Kriging is described. Finally, a ...

1996-12-31

274

A study of kerf characteristics in abrasive waterjet machining of graphite/epoxy composite

Without using any moduli, sheaves, stacks, nor any analytic, nor category-type arguments, we exhibit an analogue to Geometric Langlands Theory in an entirely model-independent, non-perturbative,purely smooth topological context in Artin Presentation Theory. A basic initial feature is that AP Theory, as a whole, is already, ab initio, a universal canonical 2D sigma-model, targeting smooth, compact, simply-connected 4-manifolds with a connected boundary, and its topological Planckian quantum starting point, as well as its cone-like, infinitely-generated at each stage, graded group of homology-preserving, but topology-changing transitions/interactions, exhibit the most general qualitative S-duality. We first point out the numerous mathematically rigorous, model-free, (i.e., intrinsic), topological AP analogues with the heuristic Kapustin-Witten version of Geometric Langlands theory, as well as the crucial differences between the two theories. The ...

2010-01-01

275

[Fundamental biological model for trials of wound ballistics].

Kerf geometry, kerf wall features, and cutting front characteristics of an Abrasive Waterjet (AWJ) machined Graphite/Epoxy (Gr/Ep) laminate were studied. A macroscopic analyses suggests that geometrical features associated with AWJ machining of Gr/Ep laminates are influenced by three macro regions along the cutting depth. The presence of these regions, including initial damage at jet entry, smooth cutting, and rough cutting near the jet exit, depends on the operating conditions. Design of experiments and analysis of variance were used to determine the effect of cutting parameters on kerf characteristics and to develop empirical models for kerf profile and features of the three distinct macroscopic regions. Cutting front analysis revealed that the mechanisms of material removal in AWJ machining of Gr/Ep do not change over the jet penetration depth. In general, high quality uniform cuts may be obtained by minimizing initial damage at the jet entry and by extending ...

1996-04-01

276

Two-phase interfacial area and flow regime modeling in FLOWTRAN-TF code

The aim of our experiment was the testing of effects of common ammunition on usable and slightly accessible biological tissue thereby to create fundamental simple biological model for trials of wounded ballistic. Like objective tissue was elected biological material - pork and beef hind-limbs, pork head, pork bodily cavity. It was discovered that objective tissue is able to react to singles types of shots in all spectrum results namely simple smooth penetration wound as well as splintery fracture in dependence on kind of using ammunition. Pork hind-limb was evaluated like the most suitable biological material for given object. PMID:17172163

2006-10-01

277

Two-phase interfacial area and flow regime modeling in FLOWTRAN-TF code

FLOWTRAN-TF is a new two-component, two-phase thermal-hydraulics code to capture the detailed assembly behavior associated with loss-of-coolant accident analyses in multichannel assemblies of the SRS reactors. The local interfacial area of the two-phase mixture is computed by summing the interfacial areas contributed by each of three flow regimes. For smooth flow regime transitions, the code uses an interpolation technique in terms of component void fraction for each basic flow regime.

1992-01-01

278

The Geometry of Stable Quotients in Genus One

FLOWTRAN-TF is a new two-component, two-phase thermal-hydraulics code to capture the detailed assembly behavior associated with loss-of-coolant accident analyses in multichannel assemblies of the SRS reactors. The local interfacial area of the two-phase mixture is computed by summing the interfacial areas contributed by each of three flow regimes. For smooth flow regime transitions, the code uses an interpolation technique in terms of component void fraction for each basic flow regime.

1992-12-31

279

Response of a magneto-rheological fluid damper subjected to periodic forcing in a high frequency limit

Stable quotient spaces provide an alternative to stable maps for compactifying spaces of maps. When the target is projective space and the domain curve has genus 1, these are smooth proper Deligne-Mumford stacks. In this paper we study the associated coarse moduli schemes. We show these schemes are projective, rationally connected and have Picard number 2. Then we give generators for the Picard group, compute the canonical divisor, and the cones of ample and effective divisors. In certain cases, we also give a closed formula for the Poincar\\'{e} polynomial.

2011-01-01

280

British Library Electronic Table of Contents (United Kingdom)

We have explored vibrations of a single-degree of freedom oscillator with a magneto-rheological damper subjected to kinematic excitations in a high frequency limit. Using fast and slow scales decoupling procedure we derived an effective damping coefficient in the limit of high frequency excitation. Damping characteristics, as functions of velocity, change considerably especially by terminating the singular non-smoothness points. This effect was more transparent for a larger control parameter which was defined as the product of the excitation amplitude and its frequency.

2008-01-01

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281

Reflection of electromagnetic waves by a nonuniform plasma layer covering a metal surface

Radiation safety in industrial applications

Reflection coefficients of electromagnetic waves in a nonuniform plasma layer with electrons, positive ions and negative ions, covering a metal surface are investigated by using the finite-difference-time-domain method. It is shown that the reflection coefficients are influenced greatly by the density gradient on the layer edge, layer thickness and electron proportion, i.e., the effect of the negative ions. It is also found that low reflection or high attenuation can be reached by properly choosing high electron proportion, thick plasma layer, and smooth density gradient in the low frequency regime, but sharp density gradient in the high frequency regime. (authors)

2008-07-01

282

Primary leiomyosarcoma of the prostate with lung metastasis: Report of a case diagnosed by fine-needle aspiration cytology

Oil and gas industry is the largest user of radioactive materials in Nigeria. They make use of radiation generators, sealed and unsealed radioactive sources.Some of these are potentially dangerous to human health and environment if not properly controlled. here is also the need to maintain control over occupational exposures to radiation, as well as to protect the public and the environment through proper management of wastes that may be radiologically hazardous. To minimize these, effective regulatory infrastructure is being put in place.For a smooth take-off of the nuclear power program, the National Nuclear Regulatory Authority and other stake holders in the nuclear industry need to start to put together licensing procedure for these.

2008-03-17

283

British Library Electronic Table of Contents (United Kingdom)

Abstract Prostate leiomyosarcoma is an extremely rare and highly aggressive neoplasm that accounts for less than 0.1% of primary prostate malignancies. Herein, we present a patient with primary leiomyosarcoma of the prostate with lung metastasis diagnosed primarily on fine-needle aspiration cytology. Characteristic cytological features such as small fascicles of spindle cells with blunt-ended nuclei, positivity for desmin and smooth muscle actin along with the radiological features are helpful in the correct diagnosis. Diagn. Cytopathol. 2010. 2010 Wiley-Liss, Inc.

2011-01-01

284

Nonequilibrium detonation of composite explosives

Muscarinic and nicotinic activities of the novel acetylcholine analog acetylselenonium choline.

The effect of nonequilibrium diffusional flow on detonation velocities in composite explosives is examined. Detonation conditions are derived for complete equilibrium, temperature and pressure equilibrium, and two forms of pressure equilibrium. Partial equilibria are associated with systems which have not had sufficient time for transport to smooth out the gradients between spatially separate regions. The nonequilibrium detonation conditions are implemented in the CHEQ equation of state code. We show that the detonation velocity decreases as the non-chemical degrees of freedom of the explosive are allowed to equilibrate. It is only when the chemical degrees of freedom are allowed to equilibrate that the detonation velocity increases. {copyright} {ital 1998 American Institute of Physics.}

1998-07-01

285

Multiple concentric annuli for characterizing spatially nonuniform backgrounds

The present paper further characterizes the cholinergic properties of acetylselenonium choline (ASeCh, (CH3)2Se+CH2CH2OCOCH3). The data demonstrate that ASeCh possesses muscarinic receptor agonist properties as evidenced by vasodepressor and smooth muscle contractile activities which are enhanced by physostigmine and antagonized by atropine. ASeCh also possessed nicotinic agonist activity on frog rectus abdominis tissue which was potentiated by physostigmine, and blocked by d-tubocurarine. The relative potencies of ASeCh ranged from approximately 1% to approximately 6% of the potency of acetylcholine in the three types of preparations examined. PMID:1435078

1992-01-01

286

Lifetime and fatigue limit prediction for components of high strength steels; Vorhersage der Lebensdauer und Dauerfestigkeit von Bauteilen aus hochfesten, durchhaertenden Staehlen

A method is presented for estimating the background at a given location on a sky map by interpolating the estimated background from a set of concentric annuli which surround this location. If the background is nonuniform but smoothly varying, this method provides a more accurate (though less precise) estimate than can be obtained with a single annulus. Several applications of multi-annulus background estimation are discussed, including direct testing for point sources in the presence of a nonuniform background, the generation of "surrogate maps" for characterizing false alarm rates, and precise testing of the null hypothesis that the background is uniform.

1999-01-01

287

Explosives 92. Conference proceedings

Smooth and notched specimens of the bearing steel 100Cr6 (SAE 52100) in a bainitic condition were used to determine the S-N-curves under tensile, torsional and combined in- and out-of-phase loading. In the area of high-cycle-fatigue, crack initiation was most likely caused by inclusions like Titanium Carbonitrides or Aluminium Oxides. A model was developed to describe the influence of the magnitude of these inclusions on the lifetime. A weakest link model, using the statistical distribution of inclusions and surface flaws, was used to describe the fatigue limit. (orig.)

2000-07-01

288

Experimental research on X-ray spectrum emitted from hot laser-produced aluminium plasma

17 papers are presented. Topics covered include: the POG system - a new concept in the use of ANFO; demolition of a motorway bridge; presplit and smooth blasting; VIBReX - a predictive code for assessing the effect of blast design on ground vibration; ground vibrations from blasting; digital seismographs; human response to blasting and the effects on planning conditions; landform construction by restoration blasting; use of small diameter explosives; efficient priming; safety management in the explosives industry; and the law on packaging of explosives. Two papers have been abstracted separately.

1992-01-01

289

Development of a Stable-Beta Titanium Alloy, Quarterly Report Number 10, October 1 - December 31, 1964.

The hot uniform aluminium plasma was produced by irradiating thin aluminium dotted foil smoothly with the 9th 0.53 ?m laser on Shenguang II laser facility. The emitted spectrum was measured from the front and tangential direction of the target with two crystal spectrometers, and the quantitative spectrum from the front of the target was obtained. The state of laser- produced plasma was simulated with the radiation hydrodynamics code MULTI-1D, and the emitted spectrum was calculated with the spectrum code of Collision-Radiation model under the simulated plasma state. The experimental spectrum accords with the simulated one. (authors)

2007-12-01

290

Cubature Kalman smoothers

Evaluation of ageable beta alloys Ti-17V-2Fe-2Co-3Al, Ti-17V-7.5Co-3A1 and Ti-8Mo-8V-5Co-3Al continued with room and elevated temperature smooth and notched tensile tests, creep stability, oxidation and stress-corrosion tests. Ti-17V-7.5Co-3Al aged more r...

1964-01-01

291

British Library Electronic Table of Contents (United Kingdom)

The cubature Kalman filter (CKF) is a relatively new addition to derivative-free approximate Bayesian filters built under the Gaussian assumption. This paper extends the CKF theory to address nonlinear smoothing problems; the resulting state estimator is named the fixed-interval cubature Kalman smoother (FI-CKS). Moreover, the FI-CKS is reformulated to propagate the square-root error covariances. Although algebraically equivalent to the FI-CKS, the square-root variant ensures reliable implementation when committed to embedded systems with fixed precision or when the inference problem itself is ill-conditioned. Finally, to validate the formulation, the square-root FI-CKS is applied to track a ballistic target on reentry.

2011-01-01

292

Coverage and large scale anisotropies estimation methods for the Pierre Auger Observatory

Computer processing of Moessbauer spectrum data

When searching for anisotropies in the arrival directions of Ultra High Energy Cosmic Rays, one must estimate the number of events expected in each direction of the sky in the case of a perfect isotropy. We present in this article a new method, developed for the Auger Observatory, based on a smooth estimate of the zenith angle distribution obtained from the data itself (which is essentially unchanged in the case of the presence of a large scale anisotropy pattern). We also study the sensitivity of several methods to detect large-scale anisotropies in the cosmic ray arrival direction distribution : Rayleigh analysis, dipole fitting and angular power spectrum estimation.

2005-07-01

293

Bend loss for channel plasmon polaritons

Computer processing was adopted to pick up significant signals from the undefined Moessbauer spectra. A program, by which smoothing and curve fitting was made possible, was devised and applied to the analysis of the Moessbauer spectra of "5"7Fe enriched iron and other specimens. Although this processing sometimes distorted the absorption peaks, it was quite effective for elimination of noise and finding of exact positions of absorption peaks. Availability of the processing was demonstrated by several examples obtained for "5"7Fe enriched iron, natural iron, calcined ferric oxyhydroxides, red mud residue and its calcined product. (auth.).

294

Aspiration cover for the loading site of a belt conveyer

Using near-field optical microscopy, the authors investigate propagation of channel plasmon polaritons excited in the wavelength range of 1425-1640 nm along smoothly bent and split V-shaped grooves milled in a gold film. We find that for 0.6-?m-wide and 1.1-?m-deep grooves bent with the smallest curvature radius of ?0.83 ?m, the double bend (for S bends) and splitting (for Y splitters) losses decrease for longer wavelengths approaching (in the wavelength range of 1600-1640 nm) the levels of ~0 and 0.5 dB, respectively.

2006-10-01

295

A study on the response time characteristics related to shock control in the hydraulic system using the fluid device

An aspiration cover is proposed for the site of loading a belt conveyer including a housing arranged above the belt conveyer in whose cover there is an aspiration sleeve and a discharge chute from the upper wall and a guide having a cushioning plate on the lower end. It is distinguished by the fact that in order to improve the effectiveness of removing dust by decreasing the volume of aspirated air, the cover between the aspiration sleeve and the upper wall of the loading chute is convex in the inside of the housing and has a smooth connection to the upper wall of the discharge chute turned towards the cushioning plate.

1982-01-01

296

Influence of plasma nitriding on fatigue strength and fracture of a B-Mn steel

Control of pressure transients in a hydraulic system may be important and necessary to avoid failures and to improve the efficiency of operation. Flow restricting devices can result in a decrease in the peak pressure, but may change the response time. The response time has an important effect on both operator and operator perceived smoothness. The response time should correspond to how fast a system responds to a given disturbance at the system boundary. Occasionally the appropriate response time is not easily determined. This study is on the response time characteristics in the hydraulic system studied for the control of response time.

2001-11-01

297

Comparative studies on titanium and tantalum oxides thin film structures for laser mirrors, deposited by ion assisted gun

The first part of a systematic investigation is presented of surface treatments affecting the fatigue behavior of smooth and notched quenched and tempered (Q and T) specimens made of a B-Mn SS2131 ({approx}AISI 15B21H) steel. In this part, the effects of plasma nitriding (nitriding temperature=480 C, time=24 h) on the fatigue strength and notch sensitivity were investigated. Constant stress amplitude plane reversed bending fatigue tests (R=-1) at 47 Hz were conducted using cylindrical plasma nitriding (PN) and Q and T steel specimens with K{sub t}=1.05 and 1.7. The compound layer was found to consists of {epsilon}-phase and {gamma}`-phase. S-N curves show that plasma nitriding improves the fatigue limit by 53 and 115% of Q and T smooth and notched specimens, respectively. The fatigue strength of smooth specimens is improved through the whole fatigue life but only for long fatigue lives for notched specimens. Plasma ...

1998-02-01

298

A phenomenological model of the thermal hydraulics of convective boiling during the quenching of hot rod bundles

For obtaining radiation less damagable laser mirrors, a preliminary optimization of film fabrication suitable for the analysis of laser damage mechanism has been done as the first step. Here, the optimization requires not only the stable fabrication process but also the ideal film structure i.e., the amorphous and smooth film structure simultaneously, eliminating latently unwanted secondary effects such as light scattering during laser damage test. For this purpose, we adopted the ion assisted deposition (IAD) method and modified the deposition conditions for titanium and tantalum oxide films, both of which compose typical high index layers, and where SiO_2 layers are also chosen as low index layers because of their amorphous and smooth nature, in alternative multilayer laser mirrors. Surface and cross sectional film structures and film crystallinity are compared and characterized, using a high resolution SEM and a x-ray diffractometer, ...

1996-10-07

299

[Pulmonary vascular manifestations in hereditary hemorrhagic telangiectasia].

In this paper, a phenomenological model of the thermal hydraulics of convective boiling in the post-critical-heat-flux (post-CHF) regime is developed and discussed. The model was implemented in the TRAC-PF1/MOD2 computer code (an advanced best-estimate computer program written for the analysis of pressurized water reactor systems). The model was built around the determination of flow regimes downstream of the quench front. The regimes were determined from the flow-regime map suggested by Ishii and his coworkers. Heat transfer in the transition boiling region was formulated as a position-dependent model. The propagation of the CHF point was strongly dependent on the length of the transition boiling region. Wall-to-fluid film boiling heat transfer was considered to consist of two components: first, a wall-to-vapor convective heat-transfer portion and, second, a wall-to-liquid heat transfer representing near-wall effects. Each contribution was considered separately in each of the inverted ...

1983-10-14

300

Xylem traits mediate a trade-off between resistance to freeze-thaw-induced embolism and photosynthetic capacity in overwintering evergreens

Hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease) is a genetic disorder with autosomal dominance, variable penetrance, and an estimated prevalence of 1/10,000 inhabitants in France. Diagnosis is based on clinical criteria including epistaxis, telangiectasia, visceral manifestations, and familial occurrence. Pulmonary arteriovenous malformations, present in 15-33% of patients, are its primary visceral complications. The disease may be revealed by infectious and ischemic neurological manifestations due to paradoxical embolism. The high frequency of neurologic complications even in asymptomatic patients justifies systematic screening for pulmonary arteriovenous malformations. Treatment of these malformations is based on percutaneous transcatheter coil embolization of the feeding artery. Pulmonary arterial hypertension is rare in this disease. It may be due to systemic arteriovenous shunting in the liver, which increases cardiac output, or be similar to idiopathic pulmonary ...

2005-11-01

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301

British Library Electronic Table of Contents (United Kingdom)

Summary - Hydraulic traits were studied in temperate, woody evergreens in a high-elevation heath community to test for trade-offs between the delivery of water to canopies at rates sufficient to sustain photosynthesis and protection against disruption to vascular transport caused by freeze-thaw-induced embolism. - Freeze-thaw-induced loss in hydraulic conductivity was studied in relation to xylem anatomy, leaf- and sapwood-specific hydraulic conductivity and gas exchange characteristics of leaves. - We found evidence that a trade-off between xylem transport capacity and safety from freeze-thaw-induced embolism affects photosynthetic activity in overwintering evergreens. The mean hydraulically weighted xylem vessel diameter and sapwood-specific conductivity correlated with susceptibility to...

2011-01-01

302

Treatment of hepatocellular carcinoma (HCC) with radiolabeled Lipiodol: a preliminary report

The segmental gastrocnemius muscles' flap: A cadaveric study

Fatty acid esters such as Lipiodol or Ethiodol are known to selectively localize in vascular hepatocellular carcinomas (HCC), following intraarterial hepatic administration. Lipiodol was labeled with radioactive /sup 131/I and administered in 47 patients with HCC for both imaging and therapy. The short term preliminary results suggest radiolabeled Lipiodol is effective in eliminating ascites, shrinking the tumor by a high internal radiation dose, and in improving symptomatology of these tumors. In the future, /sup 90/Y, which is a stronger pure beta-emitter (maximum beta energy of 2.27 MeV, a half life of 64 h, and a maximum penetration or beta range of 11mm), than /sup 131/I will be used for more effective treatment of HCC.

1987-12-01

303

British Library Electronic Table of Contents (United Kingdom)

The aim of this study was to evaluate the feasibility of splitting each head of the gastrocnemius muscle into two segments. This prospective study was conducted on 35 fresh cadavers with injection of radio-opaque contrast material in the popliteal artery. Seventy medial gastrocnemius and 70 lateral gastrocnemius muscle specimens were obtained. Gastrocnemius intramuscular arterial anatomy was analysed by using the digital X-ray technique. The most common vascular pattern found in this study was both bellies supplied by individual sural arteries, which shows distal bifurcation. The medial sural artery always showed bifurcation in the medial gastrocnemius muscle in both lower limbs, whereas this bifurcation of the lateral sural artery was present in only 87% cases and 13% of cases showed a si...

2011-01-01

304

Somatic and genetic radiation exposure of the patient in digital subtraction angiography (DSA)

Serum gamma-glutamyltransferase is associated with arterial stiffness in healthy individuals

The somatic and genetic radiation exposure of patients undergoing Digital Subtraction Angiography (DSA) and traditional Film Arteriography (FA) of cranial, cervical, thoracic and abdominal vascular territories are compared. The radiation doses absorbed within the critical organs - red bone marrow, lung, thyroid gland and female breast - and in the gonads were measured using an anthropomorphic Alderson phantom. A Somatic Dose Index was calculated in order to estimate the somatic radiation risk. The somatic radiation exposure depends upon the location of the critical organs with respect to the entrance site of the x-ray beam, and can be reduced by an appropriate choice of the angiographic projection. Under this condition, the radiation exposure of the patient during DSA can be lower than during FA. For renal DSA an a.p. projection, the use of an abdominal compression device and careful caudal shielding of the field are advocated. (orig.).

1986-01-01

305

British Library Electronic Table of Contents (United Kingdom)

Summary Objective- Gamma-glutamyltransferase (GGT) has been reported to be useful in predicting cardiovascular disease. Arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) is not only a marker of vascular damage but a significant predictor of cardiovascular events. Gender difference has been reported in the association between GGT and baPWV. We assessed, therefore, the association between GGT and baPWV in a large population and determined whether there was gender difference. Design- This cross-sectional study was conducted at the Asan Medical Centre, Seoul, Republic of Korea. Subjects and measurements- Serum GGT, baPWV and conventional risk factors were measured in 10 988 apparently healthy subjects (7248 men, 3740 women) who participated in a routine health screening...

2011-01-01

306

Role of cerebrospinal fluid pressure in the pathogenesis of glaucoma

British Library Electronic Table of Contents (United Kingdom)

Abstract. The pathogenesis of normal (intraocular) pressure glaucoma has remained unclear so far. As hospital-based studies showed an association of normal-pressure glaucoma with low systemic blood pressure, particularly at night, and with vasospastic symptoms, it has been hypothesized that a vascular factor may play a primary role in the pathogenesis of normal-pressure glaucoma. That assumption may, however, be contradicted by the morphology of the optic nerve head. Eyes with normal-pressure glaucoma and glaucomatous eyes with high-intraocular pressure can show a strikingly similar appearance of the optic nerve head, including a loss of neuroretinal rim, a deepening of the optic cup, and an enlargement of parapapillary atrophy. These features, however, are not found in any (other) vascula...

2011-01-01

307

Residual limb osteomyelitis: A case series from a national prosthetic centre

British Library Electronic Table of Contents (United Kingdom)

Purpose. To examine the impact of residual limb osteomyelitis (RLO) on the rehabilitation of lower limb amputees. Method. Retrospective review of the casenotes of patients with RLO. Information sought included details of amputation, clinical features of investigations for and management of RLO and its effect on rehabilitation. Results. There were seven transfemoral and three transtibial amputees. Indications for amputation were vascular disease in nine cases, trauma in one. In each case, delayed wound healing or residual limb pain prompted radiological, hematological and microbiological investigations. Average time between amputation and diagnosis was 187 days. One patient died before treatment commenced. Two transtibial amputees were treated with intravenous antibiotics while rehabilitati...

2009-01-01

308

Radiation-induced large intracranial vessel occlusive vasculopathy.

Radiation-induced large intracranial vessel occlusive vasculopathy

Two patients who developed large intracranial vessel occlusion after standard radiation therapy for brain tumor are described. This form of vascular occlusion is usually seen in patients who have previously been treated by radiotherapy for intracranial tumor who then develop a relatively acute change in neurologic status. Histology of the lesion mimics accelerated focal arteriosclerosis. The clinical and radiographic manifestations of one case were highly atypical. The vasculopathy became evident shortly after termination of radiation therapy for a fourth ventricular ependymoma, and the angiographic picture stimulated a diffuse arteritis. The second patient was more typical, with clinical symptoms developing 12 years after radiation therapy for an oligodendroglioma. Occlusion of a proximal vessel that had been included in the radiation port was demonstrated radiographically and confirmed by pathologic examination. The clinical, angiographic, and histologic features ...

1980-01-01

309

Pigpen, a nuclear coiled body component protein, is involved in angiogenesis

Two patients who developed large intracranial vessel occlusion after standard radiation therapy for brain tumor are described. This form of vascular occlusion is usually seen in patients who have previously been treated by radiotherapy for intracranial tumor who then develop a relatively acute change in neurologic status. Histology of the lesion mimics accelerated focal arteriosclerosis. The clinical and radiographic manifestations of one case were highly atypical. The vasculopathy became evident shortly after termination of radiation therapy for a fourth ventricular ependymoma, and the angiographic picture stimulated a diffuse arteritis. The second patient was more typical, with clinical symptoms developing 12 years after radiation therapy for an oligodendroglioma. Occlusion of a proximal vessel that had been included in the radiation port was demonstrated radiographically and confirmed by pathologic examination. The clinical, angiographic, and histologic features ...

1980-01-01

310

British Library Electronic Table of Contents (United Kingdom)

We previously reported that puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) is required for vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis and for endothelial differentiation from embryonic stem (ES) cells via the aminopeptidase activity of PILSAP. In this study, we searched for molecules that function during angiogenesis with PILSAP. We performed proteome analysis of nuclear extracts from embryoid bodies (EBs) made from ES cells transfected with mutant PILSAP lacking aminopeptidase activity and mock EBs. We identified pigpen, a 67-kDa nuclear coiled body component protein. Immunoprecipitation and western blotting demonstrated the binding of PILSAP and pigpen in endothelial cells (ECs), and this interaction was enhanc...

2010-01-01

311

Outcome of peripherally inserted central venous catheters in surgical and medical neonates

British Library Electronic Table of Contents (United Kingdom)

Background/Purpose: Peripherally inserted central venous catheters (PICCs) are commonly used for neonatal vascular access. The aim of this study was to look at PICC line complication rates and possible predictors of PICC infection in a neonatal intensive care unit. Method: This was a prospective study of 226 neonates who had PICCs on our neonatal intensive care unit between January 2006 and June 2009. Complete data was available on 218 neonates who had 294 PICC lines. Criteria for catheter-related sepsis was positive blood cultures (peripheral/central) and/or a positive catheter tip culture after removal in the presence of a clinical suspicion of line sepsis. Results: Of 218 neonates, 132 (169 lines) were medical, and 86 (125 lines) were surgical. Our PICC line infection rate was 17 infect...

2011-01-01

312

Multidetector Computed Tomography in the Preoperative Workup of Hilar Cholangiocarcinoma

Intermediate-conductance calcium-activated potassium channels participate in neurovascular coupling

Hilar cholangiocarcinoma is associated with a dismal prognosis; however, curative resection may offer a chance of cure. Various factors should be considered in the surgical planning for curative resection. These factors include extent of bile duct involvement, relationship between portal vein and tumor involvement, diffuse hepato duodenal ligament infiltration, vascular invasion, lymph node metastasis, peritoneal seeding, and hepatic volume. Using high-quality volume data from multidetector-row computed tomography (MDCT) and adequate postprocessing images, radiologists can provide various types of information, imperative for curative resection of a hilar cholangiocarcinoma. This review illustrates the role of MDCT in the preoperative workup of hilar cholangiocarcinoma.

2009-10-01

313

British Library Electronic Table of Contents (United Kingdom)

BACKGROUND AND PURPOSE Controlling vascular tone involves K+ efflux through endothelial cell small- and intermediate-conductance calcium-activated potassium channels (KCa2.3 and KCa3.1, respectively). We investigated the expression of these channels in astrocytes and the possibility that, by a similar mechanism, they might contribute to neurovascular coupling. EXPERIMENTAL APPROACH Transgenic mice expressing enhanced green fluorescent protein (eGFP) in astrocytes were used to assess KCa2.3 and KCa3.1 expression by immunohistochemistry and RT-PCR. KCa currents in eGFP-positive astrocytes were determined in situ using whole-cell patch clamp electrophysiology. The contribution of KCa3.1 to neurovascular coupling was investigated in pharmacological experiments using electrical field stimulatio...

2011-01-01

314

In vivo chicken model for peripheral intravascular human fibrin clot detection

In vitro and in vivo evaluation of [{sup 123}I]-VEGF{sub 165} as a potential tumor marker

A chicken model was prepared that provides a simple and economical method of evaluating the use of fibrin-specific monoclonal antibody 64C5 in the detection of peripheral vascular thrombi. Human fibrin was clotted in segments of a chicken's femoral artery and vein prior to intravenous injection of radioiodinated antibody 64C5. After a 3-hr perfusion time, the thrombosed and contralateral control segments of the vessels were excised and counted for radioactivity. The radiolabeled 64C5 uptake ratio of the thrombosed segment to the control segment was 5.4 +/- 1.2 (p less than 0.007) in the femoral artery, and 3.8 +/- 1.1 (p less than 0.02) in the femoral vein. This in vivo chicken model may also find application in studies of targeting agents for human fibrin.

1988-08-01

315

Efficient elimination of sweetpotato little leaf phytoplasma from sweetpotato by cryotherapy of shoot tips

One of the research challenges in oncology is to develop new biochemical methods for noninvasive tumor therapy evaluation to determine whether the chemotherapeutics is effective. Vascular endothelial growth factor (VEGF) was labeled with radioiodine and evaluated in vitro as well as in vivo, using A2058, a melanoma cell line overexpressing VEGFR-1 and -2. Saturation binding analysis with [{sup 125}I]-VEGF resulted in a K {sub d} of 0.1 nM. Internalization assays indicate the preserved ligand induced internalization and metabolization of the tracer. Biodistribution studies with [{sup 123}I]-VEGF in wild type and A2058 tumor-bearing athymic mice showed low background activity and a tumor to reference tissue ratio of maximum 6.12. These results suggest that [{sup 123}I]-VEGF is a potentially suitable tracer for tumor therapy evaluation.

2005-07-01

316

British Library Electronic Table of Contents (United Kingdom)

Shoot tips with 3-4 leaf primordia were excised from in vitro-grown sweetpotato plants (Ipomoea batatas) infected with little leaf phytoplasma (Candidatus Phytoplasma aurantifolia) and subjected to cryotherapy. All plants regenerated from the cryo-treated shoot tips were free of phytoplasma, whereas shoot tip culture or dehydration of shoot tips without subsequent cryotherapy resulted in phytoplasma-free plants at a frequency of only 7-10%. Histological and ultrastructural studies with light and transmission electron microscopy, respectively, indicated that cryotherapy was lethal to all cells except those in the apical dome of the meristem and the two youngest leaf primordia. These surviving parts of the shoot tip contained vascular tissue and sieve elements, but electron microscopy showed...

2008-01-01

317

Effect of postharvest water deficit stress on gene expression in heads of broccoli (Brassica oleracea var. italica)

British Library Electronic Table of Contents (United Kingdom)

Harvested plant organs such as heads of broccoli (Brassica oleracea L. var. italica) experience a range of stresses that can lead to premature reduction in quality and eventual senescence. Understanding plant responses to stress may open up novel opportunities to extend postharvest life. One of the first stresses experienced by harvested organs is likely to be water deficit stress since severance of the vascular system halts the normal flux of water into the tissue. For broccoli branchlets with their cut ends held in water, transcriptome analysis based on hybridization of broccoli floret mRNA to a heterologous Arabidopsis microarray revealed that the transcript abundance of 431 genes reliably changed within 48h of harvest. Of these, transcripts of 146 genes increased and 34 genes decreased...

2011-01-01

318

Effect of Tong Luo Jiu Nao on Ab-degrading enzymes in AD rat brains

British Library Electronic Table of Contents (United Kingdom)

Ethnopharmacological relevance: Tong Luo Jiu Nao (TLJN) is a modern Chinese formula based on Traditional Chinese Medicine theory that has been used to treat ischemic cerebral stroke and vascular dementia. TLJN belongs to the ethnopharmacological family of medicines. In this study, we investigated the mechanism of the TLJN effect on Alzheimer's disease (AD). Aim of the study: To investigate the effect of TLJN on b-amyloid-degrading enzymes and learning and memory in the AD rat brain. Materials and methods: AD rats whose disease was induced by Ab25-35 injection into the bilateral hippocampus CA1 region were subjected to intragastric administration of various preparations. The experimental animals were healthy male Sprague-Dawley rats which were randomly divided into normal, sham, model, TLJN...

2011-01-01

319

Comparison of skeletal and bone marrow radionuclide scintimetry of femoral neck fracture

Comparison of skeletal and bone marrow radionuclide scintimetry of femoral neck fracture

Twenty-six patients with late complications following femoral neck fracture were examined with both skeletal and bone marrow radionuclide scintimetry. There was no correlation between the methods with respect to the quantitative assessment of femoral head vascularity based on different uptake ratios comparing the fractured and the intact side. Skeletal scintimetry always had good image quality and permitted reliable differentation between nonunion of the fracture and late segmental collapse, in contrast to bone marrow scintimetry which gave poor image quality. Skeletal scintimetry thus seems superior to bone marrow scintimetry for assessment and differential diagnosis of late complications following femoral neck fracture. It is emphasized that the physiological mechanisms for radionuclide uptake must be taken into account when comparing scintimetric studies using different tracers.

1984-01-01

320

CF findings of bowel infarction in 56 surgical patients, 5 of whom with reversible ischemia

Twenty-six patients with late complications following femoral neck fracture were examined with both skeletal and bone marrow radionuclide scintimetry. There was no correlation between the methods with respect to the quantitative assessment of femoral head vascularity based on different uptake ratios comparing the fractured and the intact side. Skeletal scintimetry always had good image quality and permitted reliable differentation between nonunion of the fracture and late segmental collapse, in contrast to bone marrow scintimetry which gave poor image quality. Skeletal scintimetry thus seems superior to bone marrow scintimetry for assessment and differential diagnosis of late complications following femoral neck fracture. It is emphasized that the physiological mechanisms for radionuclide uptake must be taken into account when comparing scintimetric studies using different tracers. (author).

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321

Bilateral brachial pull-through technique for stenting in a patient with stenosis of the vertebral artery origin: technical case report

Bowel infarction is a rare and typical condition of the elderly; despite improvements in diagnostic imaging and vascular surgery, bowel infarction remains a major cause of acute abdomen, with mortality rates ranging 70-80%. Diagnosis on often late because clinical sings, laboratory data and radiologic findings are a specific. The authors investigated radiographic and particular CT patterns of intestinal infraction in 56 patients submitted to surgery within 12 hours of admission. We also report the CT findings of 5 of these patients who had reversible mesenteric ischemia. CT is more sensitive than radiography and does not exhibit the limitations of angiography (i.e., invasiveness, radiation exposure an complex organization. Therefore CT can presently be considered the method of choice in patients with suspected bowel infarction.

1999-04-01

322

A method of stereotaxic localization adopted for conventional and digital radiography

Stenting for stenosis of the proximal vertebral artery (VA) is commonly performed via a femoral approach. However, iliofemoral occlusive disease such as arteriosclerosis obliterans sometimes prevents safe transfemoral access. In certain situations where both femoral access and ipsilateral brachial access are difficult because of a concomitant vascular diseases or particular anatomic setting, a contralateral brachial approach using the brachiobrachial pull-through technique may allow efficient and accurate stenting. A case of VA origin symptomatic stenosis successfully treated with stenting using the new pull-through technique from the contralateral brachial artery to the brachial artery on the affected side is described. (orig.)

2007-10-01

323

Studies on the biological effects of chemical defense mechanisms in vivo activated by low-dose irradiation

A method for the determination of stereotaxic coordinates in radiography, e.g. angiography, pneumoencephalography or digital vascular radiography, is described. A special localization frame containing radiopaque structures and scales defines a diagnostic coordinate system. This frame is fixed to the X-ray-table prior to the radiographic procedure and two projections are obtained at arbitrary angles to each other. The focus-film distances do not have to be fixed. The target coordinates are then determined either by a simple graphical procedure or with the use of a digitizing x-y-table, by a computer. With the computer method the films are placed on the digitizing table and the target and a few reference points are marked using a cursor. From the relative positions the computer calculates the coordinates. With the special head fixation system, coordinates of structures visualized in radiographic examinations can be transferred to various therapeutic or diagnostic ...

1986-01-01

324

On the stability of Innovar, a neuroleptic analgesic, for cardiovascular experiments.

Active oxygens produced by low-dose irradiation can induce the synthesis of proteins involved in the active oxygen reduction path and can activate the chemical self-defense mechanisms in vivo, which can alleviate the injuries caused by active oxygens themselves. The following findings suggests that it is not only by low-dose irradiation that can induce the responses described above but also by any physical and/or chemical stresses which can produce small amount of active oxygens in vivo. 1. X-irradiation with 0.5 Gy and/or water immersion and restraint induced heat shock protein (HSP)70 in rat stomach cells. HSP70 was also induced in adrenal cells by paraquat administration. 2. The SOD activity in pancreas of rat significantly increased by #gamma#-irradiation with 0.5 Gy. 0.5 Gy irradiation preceeding the alloxan administration significantly suppressed the increase in pancreatic lipid peroxides and in blood glucose levels, degranulation in #beta# cells, and decrease in blood insulin ...

325

Nuclear Reactor Sharing Program

The effects of 0.2 and 0.5 mL/kg Innovar (a neuroleptic analgesic) on cardiovascular functions and reflexes in rabbits were measured. We recorded the effects of Innovar on arterial pressure, heart rate, respiration rate, ventricular contractility, arterial oxygen tension, as well as the drug's effects on the bradycardia and vasoconstrictor response to cigarette smoke stimulation of the nose (the so-called "nasopharyngeal reflex"). In animals given 0.2 mL/kg Innovar, all steady state cardiovascular variables had returned to pre-Innovar levels in 45 min, as had the efficacy of the nasopharyngeal reflex. In animals given 0.5 mL/kg Innovar, all steady state cardiovascular variables, except PaO2, were slightly but significantly depressed for up to 135 min after injection. The nasopharyngeal reflex returned to normal within 90 min. Because of the calmative and analgesic effects of Innovar, and its only moderate effects on cardiovascular functions and reflexes, we feel it ...

1981-11-01

326

MR imaging of experimental intramuscular hemorrhage at 0. 02 T; Contrast enhancement with Gd-DOTA

The Ohio State University Research Reactor (OSURR) is licensed to operate at a maximum power level of 500 kW. A pool-type reactor using flat-plate, low enriched fuel elements, the OSURR provides several experimental facilities including two 6-inch i.d. beam ports, a graphite thermal column, several graphite-isotope-irradiation elements, a pneumatic transfer system (Rabbit), various dry tubes, and a Central Irradiation Facility (CIF). The core arrangement and accessibility facilitates research programs involving material activation or core parameter studies. The OSURR control room is large enough to accommodate laboratory groups which can use control instrumentation for monitoring of experiments. The control instrumentation is relatively simple, without a large amount of duplication. This facilitates opportunities for hands-on experience in reactor operation by nuclear engineering students making reactor parameter measurements. For neutron activation analysis and ...

1994-09-01

327

Ixodes ricinus: vector of a hitherto undescribed spotted fever group agent in Switzerland.

Intramuscular hermorrhage was induced by injecting autologous blood into the paraspinal muscle of 8 rabbits. In order to evaluate the time-dependent changes of hemorrhage observed on MRI, the animals were imaged at different stages of blood resolution at 0.02 tesla (T), and control examined with ultrasound using a 7.5 MHz linear transducer. Six inversion recovery sequences (TR=1 000 ms. TE=30 ms, and TI=18, 48, 148, 201, 302, and 398 ms) were used for the invivo calculation of T1 relaxation times. IR 1 000 (398)/30 imaging was performed before and after the Gd-DOTA administration. The hemorrhage was evident on MR images throughout the study, especially on the T2 weighted (SE 1 000/100) images. MRI showed the healing lesion longer than ultrasound. The T1 relaxation time increased during the time of resolution. Lesions on days 4 to 7 enhanced in intensity after the injection of Gd-DOTA. (orig.).

1990-09-01

328

Differentiation to adipocytes in accompanied by an increase in the amounts of Gi- and Go-proteins in 3T3-L1 cells

A tick/rickettsial survey in various parts of Switzerland revealed the presence of a new, hitherto undescribed spotted fever group rickettsia ("Swiss agent") in up to 11.7% of I. ricinus collected off vegetation. Infection in ticks was found to be generalized with rickettsiae developing intracellularly and occasionally also intranuclearly. As a result of massive growth in ovarial tissues, including the germinative cells, the rate of transovarial and filial infection was 100%. The "Swiss agent" appears to be nonpathogenic for guinea pigs, domestic rabbits, and Swiss mice, but in male meadow voles (Microtus pennsylvanicus) it produces a microscopically detectable infection in the tunica vaginalis. The rickettsia grows well in tissue culture systems including chick embryo fibroblast, Vero, and vole tissue cells, when inoculated via yolk sac into 5-day-old hens' eggs, it kills 100% of the embryos after 5 to 7 days. Antigenic relatedness of the "Swiss agent" to ...

1979-12-01

329

Comparison of newer synthetic and biological wound dressings.

Treatment of cultures of 3T3-L1 cells with methylisobutyl-xanthine and dexamethasone has been shown to result in accumulation of lipid and conversion to the morphology of adipocytes in more than 90% of the cells. The status of the stimulatory (Gs), inhibitory (Gi) and Go-proteins during the course of 3T3-L1 differentiation was examined. The amount of alpha subunit of Gs (#alpha#Gs), assayed by radiolabeling in the presence of cholera toxin and ["3"2P]NAD"+, increased upon differentiation as previously described by others. The amounts of #alpha#Gi and #alpha#Go assayed by radiolabeling in the presence of pertussis toxin and ["3"2P]NAD"+ increased 3-fold upon differentiation. Immunoblots of cell membranes subjected to gel electrophoresis in sodium dodecyl sulfate were probed with two rabbit antisera raised against bovine brain #alpha#Go and with one raised against the#beta#-subunit of the bovine rod-outer-segment G-protein, referred to as transducin. The ...

1986-06-08

330

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

In 18 piglets, weighing 10-15 kg, third-degree burns or full-thickness skin excisions of 4 X 4 cm were inflicted. The effect of five dressing materials on adhesiveness to the wounds, appearance, conformability, wound contraction, bacterial count, and morphology of the wound was studied at the end of the seventh and fourteenth days without dressing changes. In 11 piglets with a burn wound, the most adherent dressing was collagen sponge(CS), followed by polyurethane sponge (PU), pigskin xenograph (PS), and xeroform. CS more effectively debrided the wound from coagulated necrotic tissue than the other dressings. Wound contraction was maximal with CS dressing (52%), followed by PU (44%), xeroform (32%), and PS (27%). In another seven piglets with full-thickness excised wounds, a velour dressing made of polytetrafluoroethylene (PTFE) or PU adhered significantly more than CS or PS. Wound contraction was greater with CS (37%) or PTFE (35%) than with PS (23%) or PU (18%). The bacterial counts ...

1981-06-01

331

An immunochemical approach to the study of DNA damage and repair. Technical progress report, May 1, 1989--April 30, 1992

Two overlapping cDNA clones encoding human DNA topoisomerase II were identified by two independent methods. In one, a human cDNA library in phage {lambda} was screened by hybridization with a mixed oligonucleotide probe encoding a stretch of seven amino acids found in yeast and Drosophila DNA topoisomerase II; in the other, a different human cDNA library in a {lambda}gt11 expression vector was screened for the expression of antigenic determinants that are recognized by rabbit antibodies specific to human DNA topoisomerase II. The entire coding sequences of the human DNA topoisomerase II gene were determined from these and several additional clones, identified through the use of the cloned human TOP2 gene sequences as probes. Hybridization between the cloned sequences and mRNA and genomic DNA indicates that the human enzyme is encoded by a single-copy gene. The location of the gene was mapped to chromosome 17q21-22 by in situ hybridization of a cloned fragment to ...

1988-10-01

332

An immunochemical approach to the study of DNA damage and repair

The overall objective of this project has been to develop immunochemical methods to quantitate unique DNA base damages in order to facilitate studies on radiation-induced damage production and repair. Specifically, we have been using antibodies raised to damaged bases to quantitate unique lesions in model systems in order to evaluate their potential biological consequences. Our approach has been to synthesize modified nucleotides or nucleosides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits or to prepare monoclonal antibodies. We have been studying damages that are stable radiolysis products found in X-irradiated DNA and thus of potential biological consequence. Our aim is to build an in vitro and in vivo data base on the interactions between model DNA lesions and such cellular enzymes as DNA polymerases and repair endonucleases. Initial studies have focused on pyrimidine ring saturation products (thymine glycol.and ...

1992-05-01

333

The application of 64 multidetector CT angiography in the evaluation of carotid stenosis and follow-up of carotid endarterectomy and percutaneous transluminal stenting

The overall objective of this project has been to develop immunochemical methods to quantitate unique DNA base damages in order to facilitate studies on radiation-induced damage production and repair. Specifically, we have been using antibodies raised to damaged bases to quantitate unique lesions in model systems in order to evaluate their potential biological consequences. Our approach has been to synthesize modified nucleotides or nucleosides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits or to prepare monoclonal antibodies. We have been studying damages that are stable radiolysis products found in X-irradiated DNA and thus of potential biological consequence. Our aim is to build an in vitro and in vivo data base on the interactions between model DNA lesions and such cellular enzymes as DNA polymerases and repair endonucleases. Initial studies have focused on pyrimidine ring saturation products (thymine glycol.and ...

1992-05-01

334

Patterns of vascular invasion of intrahepatic peripheral cholangiocarcinoma examined with angiography and angiographic CT

Objective: To evaluate the diagnostic value of 64 multidetector-row CT angiography for internal carotid artery (ICA) stenosis and the application in the follow-up of carotid endarterectomy and percutaneous transluminal stenting. Methods: Forty transient ischemic attack (TIA) patients with interpretable CTA and DSA of the cervical carotid arteries were selected from May 2005 to December 2005. This yielded a total of 80 vessels. The CTA curved planar reformations (CPR) and DSA images referenced to the distal cervical internal carotid were graded by two senior neuroradiologists blindly, according to the North American Symptomatic Carotid Endarterectomy Trial (NASCET) guidelines. The paired-t test was used to verify the statistical significant difference between pre-operating and post-operating of carotid endarterectomy or percutaneous transluminal stenting in measuring the vascular diameter and area of cross section using CTA. Results: When the 70% stenosis was used ...

2006-09-01

335

Intestinal circulation during inhalation anesthesia

To evaluate the radiological patterns of vascular invasion in peripheral cholangiocarcinomas. Hepatic arteriography and portography in 20 cases with cholangiocarcinoma including 12 cases with angiographic CT were retrospectively analyzed. The arteriography showed no arterioportal shunt, hypertrophy of tumor vessel, or tumor staining extending to central portion of the mass in all cases. However, doughnut shaped peripheral tumor staining was seen until late hepatogram phase in 12 cases and compensatory hyperperfusion around the mass was seen in six cases (eight cases if include arterial CT). Encasement of tumor vessel was seen in 12 cases, and hypertrophy of feeding vessel in nine cases. On portography, the filling defect on segmental portal branch could be demonstrated only in 11 cases. Shape of the portal defect was tapered narrowing in six cases, abrupt narrowing in two cases but intraluminal nodular filling defect was not seen. Remaining three cases were ...

1995-01-01

336

Intestinal circulation during inhalation anesthesia

This study was designed to evaluate the influence of inhalational agents on the intestinal circulation in an isolated loop preparation. Sixty dogs were studied, using three intestinal segments from each dog. Selected intestinal segments were pumped with aortic blood at a constant pressure of 100 mmHg. A mixture of /sub 86/Rb and 9-microns spheres labeled with /sup 141/Ce was injected into the arterial cannula supplying the intestinal loop, while mesenteric venous blood was collected for activity counting. A very strong and significant correlation was found between rubidium clearance and microsphere entrapment (r = 0.97, P less than 0.0001). Nitrous oxide anesthesia was accompanied by a higher vascular resistance (VR), lower flow (F), rubidium clearance (Cl-Rb), and microspheres entrapment (Cl-Sph) than pentobarbital anesthesia, indicating that the vascular bed in the intestinal segment was constricted and flow (total and nutritive) decreased. ...

1985-04-01

337

Zinc/air battery R and D zinc/air engineering analysis for electrical vehicles: Tasks III, Final report

This study was designed to evaluate the influence of inhalational agents on the intestinal circulation in an isolated loop preparation. Sixty dogs were studied, using three intestinal segments from each dog. Selected intestinal segments were pumped with aortic blood at a constant pressure of 100 mmHg. A mixture of _8_6Rb and 9-microns spheres labeled with "1"4"1Ce was injected into the arterial cannula supplying the intestinal loop, while mesenteric venous blood was collected for activity counting. A very strong and significant correlation was found between rubidium clearance and microsphere entrapment (r = 0.97, P less than 0.0001). Nitrous oxide anesthesia was accompanied by a higher vascular resistance (VR), lower flow (F), rubidium clearance (Cl-Rb), and microspheres entrapment (Cl-Sph) than pentobarbital anesthesia, indicating that the vascular bed in the intestinal segment was constricted and flow (total and nutritive) decreased. ...

338

Wind tunnel and numerical study of a small vertical axis wind turbine

This report is an examination and analysis of the zinc-air system as the motive power source for electric vehicle propulsion. Various versions of the zinc-air system and operating schemes along with their advantages and disadvantages are discussed. Baseline cost calculations are also presented in order to compare the cost effectiveness of each of the systems. The treatise is conceptual in nature and is not based on new experimental work. The information is based on published literature and investigations carried out at ERC in the past. The study also includes recommendations and suggestions in areas that require further research and development work to achieve a smooth transition from the conceptual stage to a practical, viable, and cost effective system.

1986-12-01

339

British Library Electronic Table of Contents (United Kingdom)

This paper presents a combined experimental and computational study into the aerodynamics and performance of a small scale vertical axis wind turbine (VAWT). Wind tunnel tests were carried out to ascertain overall performance of the turbine and two- and three-dimensional unsteady computational fluid dynamics (CFD) models were generated to help understand the aerodynamics of this performance. Wind tunnel performance results are presented for cases of different wind velocity, tip-speed ratio and solidity as well as rotor blade surface finish. It is shown experimentally that the surface roughness on the turbine rotor blades has a significant effect on performance. Below a critical wind speed (Reynolds number of 30,000) the performance of the turbine is degraded by a smooth rotor surface finis...

2010-01-01

340

Wave extrapolation in the spatial wavelet domain with application to poststack reverse-time migration

Two-phase flow regime transition criteria in post-dryout region based on flow visualization experiments

A wavelet transformation is performed over each of the spatial coordinates of the scalar wave equation. This transformed equation is solved directly with a finite-difference scheme for both homogeneous and smooth inhomogeneous media. Wavefield extrapolation is performed completely in the spatial wavelet domain without transforming back into the space domain at each time step. The wavelet coefficients are extrapolated, rather than the wavefield itself. The numerical solution of the scalar wave equation in the spatial wavelet domain is closely related to the finite-difference method because of the compact support of the wavelet bases. Poststack reverse-time migration is implemented as an application. The resolution spaces of the wavelet transform provide a natural framework for multigrid analysis. Migrated images are constructed from various resolution spaces.

1998-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

Two-phase flow regime transition criteria in post-dryout region based on flow visualization experiments

A visual study of film boiling is carried out to determine the flow regime transition in the post-CHF region. An idealized inverted annular flow is obtained by introducing a liquid jet of Freon 113 through a nozzle, precisely centered with respect to the internal diameter of the test section, with an annular gas flow. The respective ranges for liquid and gas velocities are 0.05-0.5 and 0.03-8.2 m s/sup -1/. Nitrogen and helium are used in the study. For the present configuration, there are four flow regimes; namely, the smooth inverted annular flow-section, the rough wavy, agitated and dispersed flow regimes.

1988-12-01

342

Thermal radiation from hot surfaces measured by optical and calorimetric methods. Master's thesis

A visual study of film boiling is carried out to determine the flow regime transition in the post-CHF region. An idealized inverted annular flow is obtained by introducing a liquid jet of Freon 113 through a nozzle, precisely centered with respect to the internal diameter of the test section, with an annular gas flow. The respective ranges for liquid and gas velocities are 0.05-0.5 and 0.03-8.2 m s"-"1. Nitrogen and helium are used in the study. For the present configuration, there are four flow regimes; namely, the smooth inverted annular flow-section, the rough wavy, agitated and dispersed flow regimes. (author).

1988-01-01

343

The formation and removal characteristics of aerosols in ammonia-based wet flue gas desulfurization

The radiative heat loss from a surface is determined by its total hemispherical emittance, which consequently plays an important role in aerospace and solar applications. This study compares emittances measured calorimetrically with values derived from near normal incidence spectral reflectance measurements. This optical derivation is based on a number of assumptions which limit the accuracy if not sufficiency fulfilled. These assumptions include sample specularity, a straybody character beyond the range of measurement, only small variations of emittance with temperature, and a perfectly smooth sample surface. The comparison of calorimetrically and optically derived emittance performed in this study not only quantifies the errors introduced by insufficient fulfillment of the assumptions but also identifies which assumption causes the dominant error. The calorimetric emissometer, constructed for this study and based on a heat flow sensor, was calibrated with ...

1982-01-01

344

British Library Electronic Table of Contents (United Kingdom)

The characteristics of aerosol generation were studied experimentally in an ammonia-based wet flue gas desulfurization process. Particle size distributions and concentrations, morphologies and compositions before and after desulfurization were measured using an electrical low pressure impactor and scanning electron microscopy, respectively. The results show that aerosols can be generated between ammonia and sulfur dioxide resulting in gas-phase reaction and the aerosol concentration at the outlet of scrubber is significantly higher than at the inlet. Before desulfurization the particles are primarily silica-alumina minerals including O, Al, Si and C, while after ammonia-based desulfurization aerosol particles have smooth surfaces with regular structures, such as cubic and prismatic crystal...

2011-01-01

345

The cohomology ring of the GKM graph of a flag manifold of classical type

Surge pressure behavior in reduced diameter segments of shipping terminals; Comportamento de pulsos de pressao em trechos de diametro reduzido de dutos de terminais maritimos

If a closed smooth manifold $M$ with an action of a torus $T$ satisfies certain conditions, then a labeled graph $\\mG_M$ with labeling in $H^2(BT)$ is associated with $M$, which encodes a lot of geometrical information on $M$. For instance, the "cohomology" ring $\\mHT^*(\\mG_M)$ of $\\mG_M$ is defined to be a subring of $\\bigoplus_{v\\in V(\\mG_M)}H^*(BT)$, where $V(\\mG_M)$ is the set of vertices of $\\mG_M$, and is known to be often isomorphic to the equivariant cohomology $H^*_T(M)$ of $M$. In this paper, we determine the ring structure of $\\mHT^*(\\mG_M)$ when $M$ is a flag manifold of classical type directly without using the fact that $\\mHT^*(\\mG_M)$ is isomorphic to $H^*_T(M)$.

2011-01-01

346

Some properties of composite panels made from wood flour and recycled polyethylene.

In a shipping terminal, the pipeline in the pier usually has a diameter smaller than the main pipeline diameter. This diameter reduction amplifies the effects caused by hydraulic transients. It was noticed during simulations that check valves placed in the pier may introduce some error in the maximum pressure when it was modeled in a conventional fashion. The dynamic check valve model had been added to a commercial pipeline simulation software and the results was compared with a similar model using the method of characteristics. Considering a real state shipping terminal case, it was proved even a pipeline that works with low pressure and smooth elevation profile needs a detailed valve modeling to prevent the calculation of unreal pressure values in the region with diameter reduction. (author)

2004-07-01

347

Selective surface aging to improve fatigue behavior in a high-strength beta titanium alloy

This study investigated the effect of board type (unmodified vs. MAPE modified) on the surface quality and thickness swelling-water absorption properties of recycled high density polyethylene (HDPE) based wood plastic composites. Additionally, two commercially available coatings (cellulosic coating and polyurethane lacquer coating) were also applied to composite surfaces and their adhesion strength, abrasion and scratch resistance, and gloss values were determined. This study showed that modification of the composites with MAPE coupling agent increased the surface smoothness and reduced the water absorption and thickness swelling of the panels. Abrasion resistance of the composites was also improved through MAPE modification. Regardless of board type, higher scratch resistance and gloss values were observed for polyurethane lacquer coated samples compared to those of cellulosic varnish coated ones. Improvement of adhesion strength was also seen on SEM micrographs. ...

2008-12-10

348

SPH simulations of accretion flow via Roche lobe overflow and via mass transfer from Be disk

Smooth and notched fatigue behavior is presented for an age-hardenable metastable #beta#-titanium alloy (Ti-3Al-8V-6Cr-4Mo-4Zr). The as-solution heat treated condition exhibits low fatigue limits and high ductility, while the high-strength condition has higher fatigue limits, but poor ductility. A new thermomechanical technique employs shot peening and heat treating to selectively age-harden only the surface. The fatigue limit is improved to levels well above that of the high strength condition, while retaining appreciable ductility, since the bulk material remains in the solution heat treated condition. (orig./MM).

349

Predictability, complexity and learning

We compare the accretion flow onto the neutron star induced by Roche lobe overflow with that by the overflow from the Be disk, in a zero eccentricity, short period binary with the same mass transfer rate, performing three-dimensional Smoothed Particle Hydrodynamics simulations. We find that a persistent accretion disk is formed around the neutron star in both cases. The circularization radius of the material transferred via Roche lobe overflow is larger than that of the material transfered from the Be disk. Thus, the growth of the accretion disk in the former case becomes significantly slower than in the latter case. In both cases, the mass accretion rate is very small and varies little with orbital phase, which is consistent with the observed X-ray behaviour of Be/X-ray binaries with circular orbits (e.g. XTE J1543-568).

2005-01-01

350

Pore-structure models of hydraulic conductivity for permeable pavement

We define {\\em predictive information} $I_{\\rm pred} (T)$ as the mutual information between the past and the future of a time series. Three qualitatively different behaviors are found in the limit of large observation times $T$: $I_{\\rm pred} (T)$ can remain finite, grow logarithmically, or grow as a fractional power law. If the time series allows us to learn a model with a finite number of parameters, then $I_{\\rm pred} (T)$ grows logarithmically with a coefficient that counts the dimensionality of the model space. While logarithmic growth of related information theoretic quantities has been found in previous work on learning, power law growth has not been seen in this context. We find that it is associated, for example, with the learning of infinite parameter (or nonparametric) models such as continuous functions with smoothness constraints. There are connections between the predictive information and measures of complexity that have been defined both in ...

2000-01-01

351

British Library Electronic Table of Contents (United Kingdom)

SummaryPermeable pavement functions as a porous infrastructure interface allowing the infiltration and evaporation of rainfall-runoff while functioning as a relatively smooth load-bearing surface for vehicular transport. Hydraulic conductivity (k) of permeable pavement is an important hydraulic property and is a function of the pore structure. This study examines k for a cementitious permeable pavement (CPP) through a series of pore-structure models. Measurements utilized include hydraulic head as well as total porosity, (t), effective porosity (e), tortuosity (Le/L) and pore size distribution (PSD) indices generated through X-ray tomography (XRT). XRT results indicate that the permeable pavement pore matrix is hetero-disperse, with high tortuosity and t!=e. Power law models of k-t and k-e...

2011-01-01

352

Phase diagram and low temperature magnetization of Gdsub(x)Ysub(1-x)Rh_4B_4

Penile rehabilitation therapy with PDE-V inhibitors following radical prostatectomy: proceed with caution.

The phase diagram of Gdsub(x)Ysub(1-x)Th_4B_4 between the paramagnetic, superconducting and ferromagnetic state is reported. Low temperature dc-magnetization measurements reveal that macroscopic electro-magnetic effects are of minor importance for the suppression of Hsub(2c), which shows a smooth bell-shaped behavior for x >= 0.15 with no indication of an anomaly near Tsub(c2). At low temperature in samples with x >= 0.20 a transition from type II to type I superconductivity seems to occur. The low temperature normal state susceptibility follows a Curie-Weiss law indicating reentrant behavior for x >= 0.10. (orig.).

1981-09-01

353

On the evolution of supernova remnants: Pt. 2

Penile rehabilitation therapy following radical prostatectomy is a much debated topic. Erectile dysfunction is still a significant contributor to postoperative morbidity following radical prostatectomy, despite meticulous nerve-sparing technique. Secondary smooth muscle changes in the penis have been identified as the underlying causes of penile atrophy, veno-occlusive dysfunction, and fibrosis. Initial observations that intracavernous injection therapies used on a regular basis postoperatively resulted in improvements in the return of spontaneous erectile function led to the development of penile rehabilitation protocols. Chronic dosing of PDE-V inhibitors is now commonly used by urologists after radical prostatectomy. Despite the current enthusiasm of penile rehabilitation therapy, current scientific evidence with clinical trials is still limited. PMID:19255627

2009-01-25

354

Nonlinear response and stability of a spindle system supported by Ball bearings

Supernova explosions within wind-driven bubbles are studied with 2D hydrodynamical calculations. Two different density distributions for the ejecta are considered: (i) a smooth, unfragmented power-law stratification, and (ii) a fragmented distribution. As in 1D models, the presence of the shell of interstellar swept-up matter causes the rapid evolution of the remnant to the radiative phase. The main 2D effects, for both fragmented and unfragmented ejecta, include: (i) substantial chaotic deviations from a purely radial flow in the remnant interior, (ii) efficient turbulent mixing between the ejecta and the shocked wind, resulting in homogenization of the former wind cavity, and (iii) severe distortion of the wind-driven shell by cooling and Rayleigh-Taylor instabilities. (author).

355

Modelling of two-phase natural circulation in a WWER-plant: PMK experimental results

In this effort, the nonlinear responses and stability of a spindle system supported by ball bearings are presented. The dynamics of this system is described by a set of second order differential equations with a nonlinear piecewise smooth force. The Floquet theory is applied to investigate the stability of the periodic solution. Due to the loss of contact between the raceways and balls in the ball bearing, the bending of the frequency response curves switch to the left at the weak resonance region, which is similar to the frequency response curves of a system with a soft spring. With the decrease of the bearing clearance, the bending of the frequency response curves switch to the right, which is similar to the frequency response curves of a system with a hard spring. Increase of the frequency ratio, the bending of frequency response curves transforms from left to right. The route to chaos through a period doubling process is also observed in this spindle-bearing ...

2010-09-15

356

Local heat transfer augmentation in channels with two opposite ribbed surfaces

Experiments have been performed with the PMK integral-type facility, a model of WWER-440 type PWRs, to investigate two-phase natural circulation behaviour. The phenomena to be expected in this reactor type are different from those in PWRs with vertical steam generators mainly due to the loop seal in the hot leg and the horizontal layout of the steam generator heat transfer tubes. The experiments showed that the system is repressurized when the water level drops to the hot leg elevation due to the effect of the loop seal. Opening of the loop seal can be smooth, but may lead to oscillations depending on the power and the mass inventory. Natural circulation recovers after the hot leg loop seal is opened, but then decreases with further mass inventory decrease. (orig.).

357

Ionizing feedback from massive stars in massive clusters: fake bubbles and untriggered star formation

The local heat transfer coefficient distribution of a square channel with two opposite ribbed walls was determined. The square channel was connected to a sudden contraction entrance in order to simulate the inlet condition of the turbine blade cooling passages. The test channel was heated by thin stainless steel foils with a thickness of 0.000025 m, and instrumented with 180 thermocouples. The brass ribs of a square cross-section were glued periodically, in line, onto the top and bottom walls of the foil-heated channel in patterns to achieve the desired spacing and angle-of-attack. The local heat transfer coefficients on the smooth side and the ribbed side walls, at the channel entrance and the downstream regions, were measured for eight rib configurations and three Reynolds numbers (Re = 10,000, 30,000, and 60,000).

1986-01-01

358

British Library Electronic Table of Contents (United Kingdom)

Abstract We use Smoothed Particle Hydrodynamics to simulate the formation of a massive (106-M-) stellar cluster system formed from the gravitational collapse of a turbulent molecular cloud. We investigate the hierarchical clustering properties of our model system and we study the influence of the photoionizing radiation produced by the system's multiple O-type stars on the evolution of the protocluster. We find that dense gas near the ionizing sources prevents the radiation from eroding the filaments in which most of the star formation occurs and that instead, ionized gas fills pre-existing voids and bubbles originally created by the turbulent velocity field.

2011-01-01

359

Instrumentation/control systems for small- to medium-size steel-making plants; Tekko setsubi chusho plant no keisoku seigyo system

Inhibitory effect of ?/?-carrageenan from red alga Tichocarpus crinitus on the development of a potato virus X infection in leaves of Datura stramonium L.

Fuji Electric has realized highly reliable and functional control systems by the dispersion type control system FOCUS, which uses the controller (ICS-2000) enjoying good reputation in controlling industrial plants for a long time and a personal computer with high windows operability, the former for controlling and the latter for MHI responsible for monitoring. The smelting process in a steel-making plant needs a highly reliable system for advanced control to ensure continuous operation. Fuji Electric delivered the FOCUS system to Kubota in 1998, as the smelting furnace instrumentation/control system for the cupola furnace. The system has been in service smoothly. Moreover, a total of four control systems have been delivered, 2 for steel-making furnaces and the other 2 for continuous casting. (NEDO)

1999-01-10

360

British Library Electronic Table of Contents (United Kingdom)

The effect of ?/?-carrageenan from red alda Tichocarpus crinitus on the development of a potato virus X (PVX) infection in the leaves of Datura stramonium L. has been studied. The treatment of leaves with carrageenan stimulates a protein synthesis in the cells, causing an increase in the size of nucleoli and in the number of mitochondria and membranes of the rough endoplasmic reticulum. At the same time, such treatment slightly stimulates lytic processes, causing an increase in the number of smooth endoplasmic reticulum cisternae, dictyosomes, and cytoplasmic vacuoles and the formation of cytoplasmic electron-transparent zones. The carrageenan-induced stimulation of lytic processes results in the destruction of viral particles and can be considered as one of the defense mechanisms, prevent...

2010-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Increased performance of bearings using TiC-coated balls

Improvements to the RELAP5/MOD3 reflood model and uncertainty quantification of reflood peak clad temperature

The main purpose of solid or fluid lubricants in ball-bearings is to separate the balls and races from contacting each other in so-called asperity collisions. Steel to steel contacts lead to microwelds which roughen functional rolling-contacting surfaces and deteriorate the lubricant. By using balls with a ceramic TiC coating, two goals are achieved. First, there are fewer asperity collisions because of the extreme smoothness of the high precision polished TiC coated balls. Second, if collisions do occur, there is practically no microwelding taking place, leaving the surfaces and the lubricant in good condition. Examples are given where the bearing lifetime is increased up to 10 times if the steel balls are replaced by TiC-coated balls. (orig.).

1993-11-01

362

Implementing 10 CFR Part 830 Subpart B at WIPP

This research aims to develop reliable, advanced system thermal-hydraulic computer code and to quantify the uncertainties of code to introduce the best estimate methodology of ECCS for LBLOCA. Although the one of best estimate code, RELAP5/MOD3.1 was introduced from USNRC, several deficiencies in its reflood model and some improvements have been made. The improvements consist of modification of reflood wall heat transfer package and adjusting the drop size in dispersed flow regime. The tome smoothing of wall vaporization and level tracking model are also added to eliminate the pressure spike and level oscillation. For the verification of improved model and quantification of associated uncertainty, the FLECHT-SEASET data were used and upper limit of uncertainty at 95% confidence level is evaluated. (Author) 30 refs., 49 figs., 2 tabs.

1994-06-01

363

Hypogonadism in DM1 and its relationship to erectile dysfunction

Implementation of Title 10 Code of Federal Regulations Part 830, Subpart B Nuclear Safety Management (1) was accomplished at the Waste Isolation Pilot Plant (WIPP) in a timely and efficient manner. The primary reason the transition went smoothly was that the existing safety analysis was relatively new, initially developed in 1995, and written in accordance with the safe harbor document DOE-STD-3009 (2). The WIPP Safety Analysis Report (SAR) (3) is kept up-to-date with the unreviewed safety question (USQ) process and thorough oversight and input provided by DOE-Carlsbad Field Office (CBFO) documented in the annual safety evaluation report (SER) process.

2002-02-26

364

British Library Electronic Table of Contents (United Kingdom)

Myotonic dystrophy type 1 (DM1) is characterized by both a premature appearance of age-related phenotypes and multiple organ involvement, which affects skeletal and smooth muscle as well as the eye, heart, central nervous system, and endocrine system. Although erectile dysfunction (ED) is a frequent complaint in patients with DM1, it has not been investigated in great depth. Hypogonadism, which is reported to be one of the physical causes of ED in the general population, frequently occurs in DM1. We planned this case?control study to evaluate the relationship between hypogonadism, as defined by the sexual hormone profile (FSH, LH, testosterone (T) and prolactin) and ED, as assessed by means of an internationally validated self-administered questionnaire (IIEF). DM1 patients had significant...

2011-01-01

365

High-vacuum time-resolved laser-induced incandescence of?flame-generated soot

British Library Electronic Table of Contents (United Kingdom)

We have measured time-resolved laser-induced incandescence of flame-generated soot under high-vacuum conditions (4.1?10?6 mbar) at an excitation wavelength of 532 nm with laser fluences spanning 0.06?0.5 J/cm2. We generated soot in an ethylene/air diffusion flame, introduced it into the vacuum system with an aerodynamic lens, heated it using a pulsed laser with a spatially homogeneous and temporally smooth laser profile, and recorded LII temporal profiles at 685 nm. At low laser fluences LII signal decay rates are slow, and LII signals persist beyond the residence time of the soot particles in the detection region. At these fluences, the temporal maximum of the LII signal increases nearly linearly with increasing laser fluence until reaching a plateau at ?0.18?J/cm2. At higher fluences, th...

2011-01-01

366

High-throughput screening of microscale pitted substrate topographies for enhanced nonviral transfection efficiency in primary human fibroblasts

British Library Electronic Table of Contents (United Kingdom)

Optimization of nonviral gene delivery typically focuses on the design of particulate carriers that are endowed with desirable membrane targeting, internalization, and endosomal escape properties. Topographical control of cell transfectability, however, remains a largely unexplored parameter. Emerging literature has highlighted the influence of cell-topography interactions on modulation of many cell phenotypes, including protein expression and cytoskeletal behaviors implicated in endocytosis. Using high-throughput screening of primary human dermal fibroblasts cultured on a combinatorial library of microscale topographies, we have demonstrated an improvement in nonviral transfection efficiency for cells cultured on dense micropit patterns compared to smooth substrates, as verified with flow...

2011-01-01

367

Global challenges in energy

Ge/Si nanowire mesoscopic Josephson junctions

Environmental and security concerns are stimulating global interest in hydrogen power, renewable energy, and advanced transportation technologies, but no significant movement away from oil and a carbon-based world economy is expected soon. Over the longer-term, however, a transition from fossil fuels to a non-carbon-based economy will likely occur, affecting the type of environment future generations may encounter. Key challenges will face the world's energy industry over the next few decades to ensure a smooth transition-challenges which will require government and industry solutions beginning as early as today. This paper identifies four critical challenges in energy and the choices which will have to be made on how best to confront growing pollution caused by fossil fuels and how to facilitate an eventual revolutionary-like transition to a non-carbon-based global economy.

2006-10-01

368

Gas Appliance Technology Center: Annual report, January-December 1986

The controlled growth of nanowires (NWs) with dimensions comparable to the Fermi wavelengths of the charge carriers allows fundamental investigations of quantum confinement phenomena. Here, we present studies of proximity-induced superconductivity in undoped Ge/Si core/shell NW heterostructures contacted by superconducting leads. By using a top gate electrode to modulate the carrier density in the NW, the critical supercurrent can be tuned from zero to greater than 100 nA. Furthermore, discrete sub-bands form in the NW due to confinement in the radial direction, which results in stepwise increases in the critical current as a function of gate voltage. Transport measurements on these superconductor-NW-superconductor devices reveal high-order (n = 25) resonant multiple Andreev reflections, indicating that the NW channel is smooth and the charge transport is highly coherent. The ability to create and control coherent superconducting ordered states in ...

2006-01-01

369

Future directions in controlling the LAMPF-PSR Accelerator Complex at Los Alamos National Laboratory

The report reviews the activity during the fourth year of Gas Research Institute's Gas Appliance Technology Center program. Work on gas appliances involved a conceptual table-top multi-function oven, development of an indirect-fired conveyor oven, and performance comparisons of smooth cooktops. Performance-evaluation methods for commercial ovens were evaluated. Design improvements were made to a direct-fired conveyor oven and a pulse-combustion deep-fat fryer. Performance of common vents were studied, and a device was designed to allow incorporation of appliances with positive vent pressures into such systems. Standards-related work included draft-hood capacities, flexible corrugated-connector corrosion, and sediment trap efficiencies. Heating-related work comprised conceptual design of a vented baseboard heater and a centralized heat-transfer fluid system.

1987-08-01

370

Forced convective heat transfer in cross-corrugated solar air heaters

Four interrelated projects are underway whose purpose is to migrate the LAMPF-PSR Accelerator Complex control systems to a system with a common set of hardware and software components. Project goals address problems in performance, maintenance and growth potential. Front-end hardware, operator interface hardware and software, computer systems, network systems and data system software are being simultaneously upgraded as part of these efforts. The efforts are being coordinated to provide for a smooth and timely migration to a client-sever model-based data acquisition and control system. An increased use of the distributed intelligence at both the front-end and operator interface is a key element of the projects. 2 refs., 2 figs.

1991-01-01

371

First observation of excited states in the T_z=1/2 nucleus "8"5Mo

Forced convective heat transfer in a cross-corrugated channel solar air heater has been studied experimentally using air as a working fluid. The channel was formed by two transversely positioned corrugated sheets and two flat thermally insulated side walls. One corrugated sheet was heated by a radiant heater, while the other was thermally insulated. The fluid velocity and temperature, and the wall temperature and the local heat flux across the heated corrugated sheet were measured for a variety of operating flow rates. Experimental results for the channel geometry have yielded the correlation Nu = 0.0743 (Re)[sup 0.76]. This heat-transfer coefficient is about 2.8 times that of a smooth flat channel. The experiments showed that local heat transfer rate was smaller on the valley of the corrugation than that on the peak. The ratio of the local heat transfer rates on the two locations was related to the Reynolds number.

1994-11-01

372

Fatigue lifetime and endurance-limit prediction for high-strength steels; Vorhersage der Lebensdauer und Dauerfestigkeit von hochfesten, durchhaerteten Staehlen

Excited states in the T_z=(1/2) nucleus "8"5Mo have been observed for the first time with the reaction "5"8Ni("3"2S,#alpha#n#gamma#) at 105 MeV. #gamma#-ray transitions in this nucleus have been assigned unambiguously by combining the information from the GASP #gamma#-ray array, the ISIS silicon ball, and the n-Ring neutron detector. Two band structures have been observed in this nucleus; they continue the smooth evolution of the known bands from the lighter N=43 isotones and have been tentatively assigned spins and parity on this basis. After reaching a maximum of collectivity at "8"3Zr, the trend with increasing mass is reversed, showing a smaller collectivity at "8"5Mo. The rotational behavior of the observed bands is discussed on the basis of the projected shell model calculations.

2002-03-01

373

Extremum-Preserving Limiters for MUSCL and PPM

Smooth and notched specimens of the bearing steel 100Cr6 (SAE 52100) in a bainitic condition were used to determine the S-N curves under tensile, torsional and combined in- and out-of-phase loading. In the area of high-cycle fatigue, crack initiation was most likely caused by inclusions like Titanium Carbon nitrides or Aluminium Oxides. A micro mechanical model for the crack initiation by inclusions was developed. Another model was developed to describe the influence of these inclusions on the lifetime. A weakest-link model, using the statistical distribution of inclusions and surface flaws, was used to describe the endurance limit. (orig.)

2002-07-01

374

Experimental studies on fumigation of ethanol in a small capacity Diesel engine

Limiters are nonlinear hybridization techniques that are used to preserve positivity and monotonicity when numerically solving hyperbolic conservation laws. Unfortunately, the original methods suffer from the truncation-error being first-order accurate at all extrema despite the accuracy of the higher-order method. To remedy this problem, higher-order extensions were proposed that relied on elaborate analytic and geometric constructions. Since extremum-preserving limiters are applied only at extrema, additional computational cost is negligible. Therefore, extremum-preserving limiters ensure higher-order spatial accuracy while maintaining simplicity. This report presents higher-order limiting for (i) computing van Leer slopes and (ii) adjusting parabolic profiles. This limiting preserves monotonicity and accuracy at smooth extrema, maintains stability in the presence of discontinuities and under-resolved gradients, and is based on constraining the interpolated ...

2009-01-01

375

British Library Electronic Table of Contents (United Kingdom)

To diversify the mix of domestic energy resources and to reduce dependence on imported oil, ethanol is widely investigated for applying in combination with Diesel fuel to reduce pollutants, including smoke and NOx. Present work aims at developing a fumigation system for introduction of ethanol in a small capacity Diesel engine and to determine its effects on emission. Fumigation was achieved by using a constant volume carburetor. Different percentages of ethanol fumes with air were then introduced in the Diesel engine, under various load conditions. Ethanol is an oxygenated fuel and lead to smooth and efficient combustion. Atomization of ethanol also results in lower combustion temperature. During the present study, gaseous emission has been found to be decreasing with ethanol fumigation. ...

2011-01-01

376

Experimental Study of Nucleate Pool Boiling of FC-72 on Smooth Surface under Microgravity

British Library Electronic Table of Contents (United Kingdom)

Experiments of highly subcooled nucleate pool boiling of FC-72 with dissolved air were studied both in short-term microgravity condition utilizing the drop tower Beijing and in normal gravity conditions. The bubble behavior and heat transfer of air-dissolved FC-72 on a small scale silicon chip (10 ? 10 ? 0.5?mm3) were obtained at the bulk liquid subcooling of 41?K and nominal pressure of 102?kPa. The boiling heat transfer performance in low heat flux region in microgravity is similar to that in normal gravity condition, while vapor bubbles increase in size but little coalescence occurs among bubbles, and then forms a large bubble remains attached to the heater surface during the whole microgravity period. Thermocapillary convection may be an important mechanism of boiling heat transfer in ...

2011-01-01

377

Development of titanium diboride coatings deposited by PACVD

Development of a Weekly Load Forecasting Expert System

TiB{sub 2} appears to be a promising material for the wear protection in various tribological systems, e.g. the diecasting of Al. This study focuses on the development of titanium boride coatings deposited by PACVD, a deposition method which is most suitable for the coating of substrates with complex shapes. All layers analysed are very smooth and exhibit a quasi-amorphous fracture surface. XRD and TEM analysis indicate a nanocrystalline structure with grain sizes in the order of 2 nm. The diffraction patterns can well be correlated to titanium diboride. WDS reveals an over stoichiometric B/Ti ratio. The layer hardness reaches the value of 33 GPa and the critical load in scratch tests rises to 35 N. Neither 100Cr6 nor Al as a counterpart in pin-on-disk tests leads to wear of the coating. (orig.)

2000-09-01

378

Design and development of an innovative hybrid powder based on a computer simulation and its application to foundation makeup products

This paper describes the weekly load forecasting expert system (named WLoFy) which was developed and implemented for korea electric power corporation(KEPCO). WLoFy was designed to provide user oriented features with a graphical user interface to improve the user interaction. The various forecasting models such as exponential smoothing, multiple regression, artificial neural networks, rule-based model, and relative coefficient model also have been included in WLofy to increase the forecasting accuracy. The simulation based on historical data shows that the weekly forecasting results from WLoFy is an improvement when compared to the results from the conventional methods. Especially the forecasting accuracy on special days has been improved remarkably. (author). 9 refs., 5 figs., 6 tabs.

1999-04-01

379

British Library Electronic Table of Contents (United Kingdom)

An innovative hybrid powder prepared using computer simulation allowed development of a new foundation having a fine, smooth texture that has never been achieved before. The optical structure/design of the powder was based on the results of measurements and analyses conducted on the optical characteristics of a baby's delicate skin, which is the envy of many women. To obtain the optimal optical characteristics, the finite differential time domain (FDTD) method for solving Maxwell's differential equation by difference and time domain was applied to the computer simulation method. For synthesis of the hybrid powder based on the optical model, a proprietary shape regulation coating technology was used in which flaky substrates were coated with microspherical forms of barium sulfate crystals. ...

2008-01-01

380

Current status and future plan of nuclear fuel cycle in Japan, with focus on human resource development

Conceptual Design of a Support Structure and an Assemble of Detectors Inside a Large Solenoid

Japan's basic nuclear policy is to reprocess spent fuel and to effectively use the recovered plutonium and uranium. MOX fuel utilization in LWRs is promoted in 16-18 reactors by FY2015. Commercial operation of Rokkasho Reprocessing Plant is planned to start in 2012. Prototype reactor 'Monju' restarted operation in May 2010. From FY 2007, Fast Reactor Cycle Technology Development Project (FaCT project) started which focuses more toward the commercialization stage FBR cycle. Basic scenario of Japan's R and D aims for realization of demonstration FBR by around 2025 and introducing commercial FBRs before 2050. Smooth transition from LWR fuel cycle to FBR one is an important point. For nuclear fuel cycle which requires long term R and D, human resources development and keeping is vitally important. (author)

2010-10-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

381

CT findings of malignant lymphoma of the anterior mediastinum. Differentiation from invasive thymoma

In this note we describe a support structure which will hold detector systems (ITS, TPC, TOF) inside the large solenoid. An overall view of ALICE detector is shown on Fig.1. The support structure consists of 2 rings which fixed to an iron yoke and spokes which connect TPC and TOF to these rings. The ITS is connected by spokes to TPC end caps. Between coils there are 7cm spacings which will allow to fix rings to the yoke this support structure will allow to assemble ITS, TPC and TOF together (Fig.2) somewhere on the surface and then transport to the pit and install in the magnet. Two rings (1) are connected with four bars (2). On the bottom bars there are rolls (3) which will allow smoothly insert detectors into the magnet. Spokes (4) are uniformly distributed.

1993-01-01

382

An Intrinsic Approach to Forces in Magnetoelectric Media

CT findings were compared retrospectively between 9 cases with malignant lymphoma of the anterior mediastinum and 8 cases with invasive thymoma. CT findings of malignant lymphoma were as follows: (1) The majority of the tumors were bilateral and extended beyond the anterior mediastinum to the other mediastinum compartments. (2) Their margin was either smooth or lobulated. (3) Their density was either homogeneous or heterogeneous. In the case with heterogeneous density, ring, triangle and/or band-like low density areas, just like interspace of fused lymph nodes, were demonstrated. Calcification or cysts could not be shown. (4) Patent inherent vessels without deviation were occasionally demonstrated running through the tumors. (5) The tumors faced and contacted widely to anterior chest wall and often pressed the lung laterally at the anterior parietomediastinal pleural reflection. (6) Pleural implants were not demonstrated. (author).

1989-04-01

383

A method for preventing cathodic deposition of molybdenum subchloride in LiCl-KCl molten salt

This paper offers a conceptually straightforward method for the calculation of stresses in polarisable media based on the notion of a drive form and its property of being closed in spacetimes with symmetry. After an outline of the notation required to exploit the powerful exterior calculus of differential forms, a discussion of the relation between Killing isometries and conservation laws for smooth and distributional drive forms is given. Instantaneous forces on isolated spacetime domains and regions with interfaces are defined, based on manifestly covariant equations of motion. The remaining sections apply these notions to media that sustain electromagnetic stresses, with emphasis on homogeneous magnetoelectric material. An explicit calculation of the average pressure exerted by a monochromatic wave normally incident on a homogeneous, magnetoelectric slab in vacuo is presented and the concluding section summarizes how this pressure depends on the parameters in ...

2008-01-01

384

A hybrid time-frequency method based on improved Morlet wavelet and auto terms window

Effects of ions of Group IA, IIA, IIIB, and VIIB elements on the cathodic deposition of a molybdenum were investigated in a KCl-LiCl (eutectic)-MoCl/sub 3/ molten salt at 773 K (500/degree/C). The results can be summarized as follows: The addition of potassium, rubidium, cesium, and barium cations and fluorine anions to the KCl-LiCl (eutectic)-MoCl/sub 3/ molten salt is effective in depressing the cathodic deposition of the molybdenum subchloride, which hinders the smooth, flat electrodeposition of molybdenum. The addition of lithium, sodium, magnesium, calcium, strontium, and aluminum cations and bromine and iodine anions promotes the undesirable cathodic deposition of the molybdenum subchloride.

1989-01-01

385

British Library Electronic Table of Contents (United Kingdom)

In this paper, a hybrid time-frequency method (HTM) based on the improved Morlet wavelet and auto terms window (ATW) is presented. The Morlet wavelet, for its shape is similar to the mechanical shock signals, is added two parameters which decide the shape of the mother wavelet. The added parameters and the appropriate scale parameter for continuous wavelet transformation (CWT) are calculated using the cross validation method (CVM) and the minimum Shannon entropy method. The useless noise in the original signal can be filtered by the CWT filter de-noising process. An ATW based on the Smoothed Pseudo Wigner-Ville Distribution (SPWVD) spectrum is designed as a window function to suppress the cross terms in Wigner-Ville Distribution (WVD). The gear fault diagnosis experiment results show that ...

2011-01-01

386

A categorification of Morelli?s theorem

British Library Electronic Table of Contents (United Kingdom)

We prove a theorem relating torus-equivariant coherent sheaves on toric varieties to polyhedrally-constructible sheaves on a vector space. At the level of K-theory, the theorem recovers Morelli?s description of the K-theory of a smooth projective toric variety (Morelli in Adv. Math. 100(2):154?182, 1993). Specifically, let X be a proper toric variety of dimension n and let Formula Not Shown be the Lie algebra of the compact dual (real) torus Formula Not Shown . Then there is a corresponding conical Lagrangian ??T ? M ? and an equivalence of triangulated dg categories Formula Not Shown , where Formula Not Shown is the triangulated dg category of perfect complexes of torus-equivariant coherent sheaves on X and Sh cc (M ?;?) is the triangulated dg category of complex of sheaves on M ? with co...

2011-01-01

387

{sup 99m}Tc-MDP scintigraphy of femoral head necrosis following femoral neck fracture

[Natriuretic peptides--relevance in intensive care].

Secondary ischemic necrosis of femoral head due to loss of blood supply following to femoral neck fracture is well known. The regional distribution of bone-seeking radiopharmaceuricals in the skeleton can depend on a number of factors, but bone blood flow is a major physiological determinant of regional skeletal uptake of Tc-99m polyphosphate and bone imaging may thus be used for the evaluation of vascularity of the femoral head. The authors made a comparative study of scintigraphic findings and operative findings of 28 cases of femoral neck fracture treated at Kyung Hee University Hospital from April 1980 to May 1984. The results were as follows: 1. In 16 cases of proven avascular necorsis of femoral head, scintigraphy showed absent or decreased activity in 14 cases (87.5%), while radiography showed increased density in 10 cases (62.5%). 2. In 12 cases of proven vital femoral head, scintigraphy showed increased activity in 9 cases (75%) and radiography showed ...

1985-02-15

388

Treatment of proliferative haemangiomas with the 585 nm pulsed dye laser.

The family of natriuretic peptides consists of the atria natriuretic peptide (ANP), the cerebral natriuretic peptide (BNP), the type C natriuretic peptide (CNP) and the peptide isolated from the dendroaspis snakes' poison (DNP), whose presence in humans has not been confirmed. The physiological function of ANP is in the control of arterial blood pressure by regulation of systemic vascular resistance of blood vessels. BNP is produced as one of the factors in the acute response to inflammatory tissue damage, mainly in coronary vessels. Increased serum concentrations of natriuretic peptides have been found in stress situations, such as trauma or major surgery, systemic hypotension, and in intrinsic myocardial dysfunction. High concentrations of natriuretic peptides were observed in severe sepsis, septic shock and in multiple organ failure, probably due to increased secretion by mediators of the inflammatory process.The highest concentrations of ANP and BNP were found ...

389

The treatment of chronic pain by epidural spinal cord stimulation--a 15 year follow up; present status.

Haemangiomas usually develop within the first few weeks of life, most regressing spontaneously before the age of 7 years. Some may ulcerate or compromise a vital function, in which case systemic corticosteroids, surgery or radiotherapy may be helpful. All of these treatment modalities are associated with significant morbidity. Treatment with the 585 nm flashlamp pulsed dye laser is safe and effective in the management of superficial vascular malformations. We report seven patients, under 12 months of age, who presented with proliferative haemangiomas, causing functional impairment. Ulcerated lesions were present in four patients. The patients were treated with the 585 nm pulsed dye laser (fluences 7.0-9.25 J/cm2), at intervals of 4-8 weeks. All of the lesions showed a significant reduction in size, together with improvement in the colour and integrity of the overlying skin. Treatment with the 585 nm pulsed dye laser should be considered in the management of infants ...

1996-04-01

390

The neuroimmune-endocrine axis: pathophysiological implications for the central nervous system cytokines and hypothalamus-pituitary-adrenal hormone dynamics

Pain is necessary for survival but chronic pain is disabling and causes significant health and economic problems. This study provides an understanding of the future for spinal cord stimulation. Stimulation by means of chronically implanted electrodes, was carried out in 200 patients with pain of varied benign organic etiology. In 177 of them, pain was confined to the failed back syndrome. Most patients were referred by a Pain Management Service. 226 epidural implants were used: 80 unipolar, 59 Resume, 12 bipolar, and 75 quadripolar. Patients were followed for periods of 6 months to 12 years, with a mean follow-up of 44 months. 84 patients (42%) were able to control their pain by stimulation alone, 22 patients (11%) needed occasional analgesic supplements along with their stimulation program. Pain secondary to failed back syndrome, multiple sclerosis, peripheral vascular disease, sympathetic dystrophy and diabetic neuropathy responded favorably. Pain due to cauda ...

1997-06-01

391

Scientific Electronic Library Online (English)

Abstract in english Cytokines are molecules that were initially discovered in the immune system as mediators of communication between various types of immune cells. However, it soon became evident that cytokines exert profound effects on key functions of the central nervous system, such as food intake, fever, neuroendocrine regulation, long-term potentiation, and behavior. In the 80's and 90's our group and others discovered that the genes encoding various cytokines and their receptors are e (more) xpressed in vascular, glial, and neuronal structures of the adult brain. Most cytokines act through cell surface receptors that have one transmembrane domain and which transduce a signal through the JAK/STAT pathway. Of particular physiological and pathophysiological relevance is the fact that cytokines are potent regulators of hypothalamic neuropeptidergic systems that maintain neuroendocrine homeostasis and which regulate the body's response to stress. The mechanisms ...

2000-10-01

392

The angiogram sign in pulmonary atelectasis studied with helical Computed Tomography. Incidence and value; Il segno dell'angiogramma nelle atelettasie polmonari studiate con Tomografia Computerizzata spirale. Incidenza e validita' semeiologica

The SPIRIT V Study:A Clinical Evaluation of the XIENCE V Everolimus-Eluting Coronary Stent System in the Treatment of Patients With De Novo Coronary Artery Lesions

In this issue it has been investigated the yield of Helical CT in the study of lung vessels, the incidence of the angiogram sign and its actual value. July 1997 to December 1998, were studied 30 cases of pulmonary collapse of different origin. It was found 15 cases of passive collapse (10 from pleural effusion, 2 from diaphragmatic compression, 2 from traumatic pneumothorax, and 1 from isthmic aortic aneurysm), 12 cases of obstructive collapse (9 from bronchogenic carcinoma, 1 from mucoid obstruction, 1 from ilar lymphadenopathy, and 1 from mediastinal cancer), 2 cases of adhesive collapse and 1 case of round atelectasis. All the examinations were performed with the Helical technique during nonionic iodinated contrast agent injection (bolus, 300-350 mg/mL); it was used an automatic injector set at 2-3 mL/s. It was studied the images for the angiogram sign, that is hyperdense bands, usually longer than 2 cm, through the collapsed lung, which correspond to normal pulmonary ...

1999-12-01

393

British Library Electronic Table of Contents (United Kingdom)

ObjectivesThe SPIRIT V (A Clinical Evaluation of the XIENCE V Everolimus-Eluting Coronary Stent System in the Treatment of Patients With De Novo Coronary Artery Lesions) study is a post-market surveillance experience of the XIENCE V (Abbott Vascular, Santa Clara, California) everolimus-eluting stent (EES) in patients with higher-risk coronary anatomy. BackgroundPrevious pre-approval studies have shown the safety and efficacy of EES in highly selected groups of patients. MethodsThe SPIRIT V trial is a prospective, open label, single arm, multicenter study. Two thousand seven hundred patients with multiple de novo coronary artery lesions suitable for treatment with a planned maximum of 4 EES were enrolled at 93 centers in Europe, Asia Pacific, Canada, and South Africa. Lesions had a referenc...

2011-01-01

394

Selective absorption of ultraviolet laser energy by human atherosclerotic plaque treated with tetracycline

Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor kB and Forkhead Box O Phosphorylation

Tetracycline is an antibiotic that absorbs ultraviolet light at 355 nm and preferentially binds to atherosclerotic plaque both in vitro and in vivo. Tetracycline-treated human cadaveric aorta was compared with untreated aorta using several techniques: absorptive spectrophotometry; and tissue uptake of radiolabeled tetracycline, which showed 4-fold greater uptake by atheroma than by normal vessel. In addition, intravenous tetracycline administered to patients undergoing vascular surgery demonstrated characteristic fluorescence in surgically excised diseased arteries. Because of tetracycline's unique properties, the authors exposed tetracycline-treated and untreated aorta to ultraviolet laser radiation at a wavelength of 355 nm. They found enhanced ablation of tetracycline-treated atheroma compared with untreated atheroma. The plaque ablation caused by ultraviolet laser radiation was twice as extensive in tetracycline-treated vs nontreated plaque. This study ...

1985-05-01

395

British Library Electronic Table of Contents (United Kingdom)

We hypothesized that I kappa B kinase (IKK)-mediated nuclear factor kappa B and forkhead BoxO3a phosphorylation will be associated with age-related endothelial dysfunction. Endothelium-dependent dilation and aortic protein expression/phosphorylation were determined in young and old male B6D2F1 mice and old mice treated with the IKK inhibitor, salicylate. IKK activation was greater in old mice and was associated with greater nitrotyrosine and cytokines. Endothelium-dependent dilation, nitric oxide (NO), and endothelial NO synthase phosphorylation were lower in old mice. Endothelium-dependent dilation and NO bioavailability were restored by a superoxide dismutase mimetic. Nuclear factor kappa B and forkhead BoxO3a phosphorylation were greater in old and were associated with increased express...

2011-01-01

396

Retrieval of intravascular foreign bodies with goose neck snare

Repair of the radiation induced rectovaginal fistulas without or with interposition of the bulbocavernosus muscle (Martius procedure)

Purpose: to evaluate the efficacy and advantages of the snare systems in the retrieval of foreign bodies from vascular system. Materials and methods: the snare technique has been used for intravascular foreign body retrieval. We performed percutaneous extraction of intravascular foreign bodies using combination multipurpose catheters and a nitinol snare loop. In this report, we evaluated the patients who had performed endovascular device reposition or foreign body retrieval from 1998 to 2001. Results: foreign body retrieval was performed in 15 patients. The foreign bodies consisted of seven fractured port catheters, one sheath fragment, one embolization coil, four wire fragments, one pace-maker transducer and one dislocated endovascular stent. In no case were surgical procedures required, and no complications were encountered. Conclusion: the snare technique is a useful and a safe method as an alternative procedure to surgery. This technique is highly effective ...

2004-03-01

397

Reconstructive surgery for the complications of pelvic irradiation

Two local repair procedures, one without (9) and the other with (14) a bulbocavernosus muscle graft were performed on 20 patients with a radiation induced rectovaginal fistula. Four patients had two procedures successively. The initial success rate of both procedures was 7/9 and 14/14 respectively. Though the initial result of the bulbocavernosus graft was obviously better, in many of the local repair procedures, subclinical radiation damage progressed, resulting in recurrence of rectovaginal fistula (5), rectovesical fistula (4), pararectal abscess (2) etc. After a mean follow up of around 10 years, the success rate of fistula repair decreased to 5/9 and 13/14 and only 2/9 and 6/14 finally remained without a colostomy. A local repair operation should be restricted to carefully selected cases. The musculus gracilis is proposed as a better vascular graft. If the general condition of the patient does not allow more aggressive reconstructive procedures, fistula repair ...

1988-04-01

398

Radiant{trademark} Liquid Radioisotope Intravascular Radiation Therapy System

Severe damage to the pelvic viscera is a complication of irradiation therapy that, unfortunately, cannot always be avoided. Resulting rectal and rectocolonic strictures, rectovaginal fistulas, and shortening and stenosis of the vagina present very difficult problems that frequently require a colostomy for relief and may permanently impair sexual function. The authors present a new approach to correction of these unfortunate lesions based on the use of proximal nonirradiated colon which serves as a vascular pedicle graft to correct the defect without a complicated and massive resection. Twenty-two such operations have been done with 19 satisfactory to excellent results and two total failures (one death from small bowel complications). All patterns and combinations of irradiation injury have been found amenable to this technique of repair. These have included both web and linear strictures with and without fistulas. In half of the patients, it was possible to make ...

1984-02-01

399

Partitioning and transport of the translocates mannitol and sucrose in the light and dark in celery (Apium Graveolens L. )

RADIANT{trademark} is manufactured by United States Surgical Corporation, Vascular Therapies Division, (formerly Progressive Angioplasty Systems). The system comprises a liquid {beta}-radiation source, a shielded isolation/transfer device (ISAT), modified over-the-wire or rapid exchange delivery balloons, and accessory kits. The liquid {beta}-source is Rhenium-188 in the form of sodium perrhenate (NaReO{sub 4}), Rhenium-188 is primarily a {beta}-emitter with a physical half-life of 17.0 hours. The maximum energy of the {beta}-particles is 2.1 MeV. The source is produced daily in the nuclear pharmacy hot lab by eluting a Tungsten-188/Rhenium-188 generator manufactured by Oak Ridge National Laboratory (ORNL). Using anion exchange columns and Millipore filters the effluent is concentrated to approximately 100 mCi/ml, calibrated, and loaded into the (ISAT) which is subsequently transported to the cardiac catheterization laboratory. The delivery catheters are modified ...

1998-01-16

400

Natriuretic peptides in the pathophysiology of congestive heart failure.

Sucrose and mannitol are major photosynthetic products and translocates in celery. Assimilate partitioning and transport were studied by pulse-labeling leaves with /sup 14/CO/sub 2/ followed by different length chases in ambient air. After a 2 h chase in the light there was more /sup 14/C in sucrose than mannitol in source leaves and their petioles. In contrast after a 2 h dark chase leaves contained more /sup 14/C in mannitol than sucrose but petioles had more /sup 14/C in sucrose than mannitol. After a 15 h chase (6 h light; 9 h dark) labeled sucrose was higher in source petiole vascular bundles than in adjacent parenchyma tissue but label in glucose and fructose was higher in the parenchyma tissue. After the 15 h chase most of the /sup 14/C remaining in developing sink leaves and their petioles was in mannitol. Although in the light mannitol:sucrose ratios are the same in leaf and petiole tissues, in the dark sucrose is initially the major translocate with ...

1987-04-01

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401

Methodological study of hemodynamic analysis of lung mass by contrast enhanced dynamic CT

A hallmark of congestive heart failure (CHF) is the activation of the cardiac endocrine system, in particular atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). The natriuretic peptides are a group of structurally similar but genetically distinct peptides that have diverse actions in cardiovascular, renal, and endocrine homeostasis. ANP and BNP are of myocardial cell origin and C-type natriuretic peptide (CNP) is of endothelial origin. ANP and BNP bind to the natriuretic peptide-A receptor (NPR-A), which, via 3',5'-cyclic guanosine monophosphate (cGMP), mediates natriuresis, vasodilatation, renin inhibition, antimitogenesis, and lusitropic properties. CNP lacks natriuretic actions but possesses vasodilating and growth inhibiting actions via the guanylyl cyclase-linked natriuretic peptide-B receptor. All three peptides are cleared by the natriuretic peptide-C receptor and degraded by the ectoenzyme neutral endopeptidase 24.11, both of which are widely expressed in ...

2000-05-01

402

Methodological study of hemodynamic analysis of lung mass by contrast enhanced dynamic CT

We investigated a method of analyzing the hemodynamics of the lung mass by contrast enhanced dynamic computed tomography (dynamic CT) to determine the difference in vascular supply between the pulmonary artery and bronchial artery using an experimental model. Our experimental model consisted of two injectors connected to two tubes, representing the pulmonary artery and bronchial artery, which were further connected to a chamber representing the lung mass. Following infusion of contrast medium into each tube with some delay time, dynamic CT scans were performed to obtain time density curves of the two tubes and the chamber. Using the time-density curve of contrast passage, flow rates from the two tubes into the chamber were calculated by the curve fitting method. Calculated values correlated well with the adopted flow rates of fluid from the injectors (r=0.893) in the experiment. The results indicate our method of individually measuring flow rates of dual-input ...

1996-06-01

403

Lipiodol-CT in the detection of tumor persistence in hepatocellular carcinoma treated with percutaneous ethanol injection

We investigated a method of analyzing the hemodynamics of the lung mass by contrast enhanced dynamic computed tomography (dynamic CT) to determine the difference in vascular supply between the pulmonary artery and bronchial artery using an experimental model. Our experimental model consisted of two injectors connected to two tubes, representing the pulmonary artery and bronchial artery, which were further connected to a chamber representing the lung mass. Following infusion of contrast medium into each tube with some delay time, dynamic CT scans were performed to obtain time density curves of the two tubes and the chamber. Using the time-density curve of contrast passage, flow rates from the two tubes into the chamber were calculated by the curve fitting method. Calculated values correlated well with the adopted flow rates of fluid from the injectors (r=0.893) in the experiment. The results indicate our method of individually measuring flow rates of dual-input ...

404

Laparoscopic diagnosis and treatment of nonpalpable testis

Our purpose was to investigate the usefulness of Lipiodol-CT for detection of residual viable neoplastic tissue in hepatocellular carcinoma (HCC) lesions treated by means of percutaneous ethanol injection (PEI). An emulsion of 5 to 20 ml iodized oil and 50 to 70 mg doxorubicin hydrochloride was intraarterially injected in 18 patients with 25 HCC lesions treated by means of PEI one to 24 months before. At CT performed 3 to 5 weeks after injection, retention of Lipiodol was observed in 9 of 13 tumors that still contained viable neoplastic tissue and in 2 of 12 tumors proven to have undergone complete necrosis after PEI. The sensitivity and specificity of Lipiodol-CT were 69.2% and 83.3%, respectively. Thus, Lipiodol-CT seems to have limited diagnostic value after PEI, probably as a consequence of the alcohol-induced vascular damage, accounting for both false-negative and false-positive results. (orig.).

1994-07-01

405

Scientific Electronic Library Online (English)

Abstract in english INTRODUCTION: Treatment of the cryptorchid testicle is justified due to the increased risk of infertility and malignancy as well as the risk of testicular trauma and psychological stigma on patients and their parents. Approximately 20% of cryptorchid testicles are nonpalpable. In these cases, the videolaparoscopic technique is a useful alternative method for diagnosis and treatment. MATERIALS AND METHODS: We present data concerning 90 patients submitted to diagnostic lapa (more) roscopy for impalpable testicles. Forty-six patients (51.1%) had intra-abdominal gonads. In 25 testicles of 19 patients, we performed a two stage laparoscopic Fowler-Stephens orchiopexy. The other 27 patients underwent primary laparoscopic orchiopexy, in a total of 29 testicles. RESULTS: We obtained an overall 88% success rate with the 2 stage Fowler-Stephens approach and only 33% rate success using one stage Fowler-Stephens surgery with primary vascular ligature. There ...

2008-06-01

406

Investigation of cardio-vascular reflex in atomic bomb survivors, (2)

Influence of manufacturing methods on the homogeneity and properties of nitinol tubular stents

Electrographic R-R interval variation was examined in a total of 915 A-bomb survivors exposed at {<=}2,000 m from the hypocenter (the {<=} 2,000 m group) and a total of 1,162 A-bomb survivors exposed at >3,000 m or entered the city after the A-bombing (the >3,000 m group). Coefficient of variation (CV) for R-R interval variation on ECG tended to be decreased with advancing age in the >3,000 m group, irrespective of sex. Especially for men in this group, CV values were significantly lower for the age group of 45 to 54 years than the groups of 65 to 74 years and 75 to 84 years. Similar tendency was observed for CV values at deep breath. Decreased CV values tended to be associated with a decrease in glucose tolerance in both men and women of the >3,000 m group. In comparing the aforementioned CV values with those in the {<=}2,000 m group, there was no significant difference between the groups. R-R interval variation on ECG was found independent of exposure condition, ...

1990-11-01

407

Infected nonunion of the long bones.

Nitinol has found growing applications in vascular stents, with the recent introduction on the market of a number of new nitinol tubular devices for coronary and peripheral usage. These stents can be produced either through the expansion of a pattern cut on a small tube (pre-cut) or by cutting the deployed design on a tube of a larger size (pre-expanded). The aim of the study was to analyze the differences of properties induced by the two manufacturing methods. For this purpose, differential scanning calorimetry (DSC) measurements were performed on various specimens from the two types of stents. A first set of measurements shows that pre-expanded stents exhibit usual A<->R<->M transformations whereas multi-stage transformations occur for pre-cut stents. Two types of DSC specimens were then prepared for each stent, corresponding to the straight sections and the curved parts of the stent. It is shown that the pre-cut stents exhibit less ...

2001-11-01

408

Hepatobiliary scintigraphy in current pediatric practice

BACKGROUND: Although definitions vary, infected nonunion has been defined as a state of failure of union and persistence of infection at the fracture site for 6 to 8 months.>). Infected nonunions of the supracondylar region of the femur are uncommon and are mostly due to a severe open fracture with extensive comminution and segmental bone loss or after internal fixation of a comminuted closed fracture. Associated factors include exposed bone devoid of vascularized periosteal coverage for more than 6 weeks, purulent discharge, a positive bacteriological culture from the depth of the wound, and histologic evidence of necrotic bone containing empty lacunae. Soft-tissue loss with multiple sinuses, osteomyelitis, osteopenia, complex deformities with limb-length inequality, stiffness of the adjacent joint, polybacterial multidrug-resistant infection, and smoking all complicate treatment and recovery. Although uncommon in incidence, infected nonunions of the long bones ...

2007-08-01

409

Hepatobiliary scintigraphy is the only non-invasive technique providing real-time assessment of hepatocytes function and bile progression from the liver to the intestine; for this reason it is of great importance in the study of jaundice and many other disorders of the liver and the biliary tract in children. Ultrasonography is the initial method of evaluating the intra- and extrahepatic bile ducts dilatation: the differential diagnosis between biliary atresia and neonatal hepatitis cannot however be done without hepatobiliary scintigraphy. Cystic fibrosis patients also require hepatobiliary scintigraphy; liver and biliary tract disease can really occur independently of the underlying disease severity and the presence of steatorrhoea. Hepatobiliary imaging in children who have undergone liver transplantation is of major importance; it can assess vascularity, parenchymal function biliary drainage, possible presence of a bile leak and obstruction; it has very good ...

1998-06-01

410

Free-electron laser beam

Effects of chronic treatment with honokiol in spontaneously hypertensive rats.

The principle and history of free-electron laser (FEL), first evidenced in 1977, the relationship between FEL wavelength and output power, the high-power FEL driven by the superconducting linac, the X-ray FEL by the linac, and the medical use are described. FEL is the vacuum oscillator tube and essentially composed from the high-energy linac, undulator and light-resonator. It utilizes free electrons in the vacuum to generate the beam with wavelength ranging from microwave to gamma ray. The first high-power FEL developed in Japanese Atomic Energy Research Institute (JAERI) is based on the development of superconducting linac for oscillating the highest power beam. In the medical field, applications to excise brain tumors (in US) and to reconstruct experimentally blood vessels in the pig heart (in Gunma University) by lasing and laser coagulator are in progress with examinations to remove intra-vascular cholesterol mass by irradiation of 5.7#mu#m FEL beam. Cancer ...

2003-06-01

411

Critical loads for vegetation. Definition, use and limits. Charges critiques pour la vegetation

The present study was performed to evaluate the antihypertensive effects of honokiol in vivo in spontaneously hypertensive rats (SHR). The effects of honokiol were investigated by determination of the blood pressure, vascular reactivity, oxidative parameters, and histologic change in the aorta. Long-term administration of honokiol (400 mg/kg/d) to SHR decreased systolic blood pressure significantly. Honokiol (200, 400 mg/kg/d) enhanced the aortic relaxation in response to acetylcholine after 49-d treatment, but had no significant effects on the relaxation to sodium nitroprusside. The oral administration of honokiol significantly increased the plasma level of NO(2(-))/NO(3(-)), but decreased the level of malondialdehyde in liver of SHR compared with the control vehicle. In addition, SHR administered honokiol showed significant reductions in the elastin bands and media thickness in the aorta. These results suggest that chronic treatment with honokiol exerts an ...

2010-01-01

412

Cognitive performance correlates with cerebrovascular impairments in multi-infarct dementia

Vegetation is a key compartment of ecosystems. It contains a large part of the biodiversity at the species level. For the evaluation of critical loads, we have to separate different receptors: lower plants (algae, fungi, lichens and mosses) and vascular plants. Trees must be distinguished due to their economic value. We analyze the different changes that pollution produces on vegetation: the state of health of individuals, changes in the biology and genetics at the population level, changes in the biodiversity or the specific composition at the community level. Calculation of critical loads is based on observational or experimental studies, in more or less controlled environments. However, they cannot yet be obtained through models of vegetation changes. Some results have been acquired at the European level, mainly for critical loads for nitrogen, but these results have come mostly from Northern Europe. Moreover, only heathlands and acidic forests have been studied ...

1993-06-01

413

Closed loop obstructions of the small bowel: role of Computed Tomography

Cerebral blood flow (CBF) was measured by the "1"3"3Xe inhalation method in patients with multi-infarct dementia (MID, N = 26), Alzheimer's dementia (AD, N = 19), and among age-matched, neurologically normal, healthy volunteers (N = 26). Cognitive performance was assessed in all subjects using the Cognitive Capacity Screening Examination (CCSE). Cerebral vasomotor responses were calculated from differences in values of mean hemispheric gray matter blood flow (Delta CBF) measured during inhalation of 100% oxygen (hyperoxia) compared with CBF measured while breathing room air. Significant correlations were found between CCSE performance and vasomotor responsiveness in patients with MID (P less than .01), but not in patients with AD or in neurologically normal volunteers. Loss of vasomotor responsiveness is an indicator of cerebrovascular disease with rigidity and/or loss of reactivity of cerebral vessels, which impairs cerebrovascular responses to situational demands and predisposes to ...

414

Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat

Small bowel obstructions can be distinguished into more simple and closed loop obstructions. The latter is a more severe condition which is often complicated by strangulation with vascular impairment, edema and intramural and mesenteric hemorrhage. Consequent arterial insufficiency rapidly leads to ischemia, infarction and necrosis. The radiologist plays a role in the early recognition of the closed loop obstruction and of any sign of strangulation. The role of CT in the diagnosis and workup of patients with suspected intestinal occlusion has been analyzed in the literature with reported 63% sensitivity, 78% specificity and 66% accuracy. CT is also capable of revealing the causes of occlusion in 73-95% of cases. The above CT signs allow to identify closed loop obstruction and also small bowel strangulation, thus supplying a valuable contribution to diagnosis and accurate preoperative evaluation. The conclusion is that CT can accurately demonstrate the presence of ...

1999-01-01

415

British Library Electronic Table of Contents (United Kingdom)

Aim/hypothesis We examined whether the renin inhibitor, aliskiren, provides similar or greater protection than ACE inhibition from non-proliferative diabetic retinopathy and from the proliferative neoangiogenesis of oxygen-induced retinopathy. Methods Transgenic (mRen-2)27 rats, which overexpress mouse renin and angiotensin in extra-renal tissues, were studied. For diabetic studies, non-diabetic, diabetic (streptozotocin, 55?mg/kg), diabetic + aliskiren (10?mg?kg?1?day?1, pump), or diabetic + lisinopril (10?mg?kg?1?day?1, drinking water) rats were evaluated over 16?weeks. For oxygen-induced retinopathy studies, rats were exposed to 80% oxygen (22?h/day) from postnatal days?0 to 11, and then room air from postnatal days?12 to 18. Aliskiren (10 or 30?mg?kg?1?day?1, pump) or lisinopril (10?mg...

2011-01-01

416

Aggressive Ewing's sarcoma appearing as a cold lesion on bone scan

A kinetic and microautoradiographic study of sup 14 C-sucrose translocation into developing wheat grains

Ewing's sarcoma classically presents as a hot spot on bone scan as a result of increased vascularity of the tumor and new bone formation. Purpose We report and analyze an uncommon pattern of a 'cold' lesion in Ewing's sarcoma on bone scan and its pathophysiologic significance. Case report A 15-year-old boy complaining of thigh pain. CT scan evoked Ewing's sarcoma or osteitis. MRI evoked chronic osteitis. Scintigraphy showed a fairly intense and heterogeneous uptake on the femoral lesion and no abnormal uptake elsewhere. Biopsy showed none pathologic pattern. Three months later, a second biopsy concluded to Ewing's sarcoma. Bone scan showed a larger lesion with peripheral intense uptake centered by enlarged 'cold' area in the left femoral diaphysis and no evident bone metastasis. The patient underwent chemotherapy and surgery. Three months later, bone scan showed extensive skeletal metastasis. Conclusion Ewing's sarcoma appears usually as an intense lesion on bone ...

2009-10-01

417

A habitat template approach to green building surfaces

The kinetics of {sup 14}C-photosynthate import by developing wheat grains was followed after pulse-labeling the flag leaf with {sup 14}CO{sub 2}. Samples were collected from four successive points along the transport pathway to and within the grain: exuding aphid stylets on the peduncle, exuding grain pedicels, the grain crease tissues, and the liquid contents of the endosperm cavity. In addition, microautoradiographs were prepared of the grain crease tissues during movement of the {sup 14}C pulse into the grain. At all times, sucrose accounted for 93 to 97% of the total {sup 14}C present at all four sampling sites. The main features of the {sup 14}C kinetics could be accounted for by a simple compartmental model consisting of sucrose pools in series. Microautoradiographs of the crease tissues showed fairly uniform labeling of vascular parenchyma at all times, with a sharp gradient in labeling across the chalaza to the nucellus. Thus the principal resistance to ...

1991-05-01

418

Ophidian envenomation strategies and the role of purines.

The use of entire plant communities of native species is gaining interest in the green roof industry. Plant communities must be matched with environmental conditions that mimic conditions in their original habitats. Urban built environments do not differ significantly from the rocky outcrops with poor, shallow soil that many plants colonize. This paper provided details of an experiment investigating the impact of plant community structure and species diversity on living roof performance. The aim of the experiment was to determine the impact of species diversity on precipitation interception, nutrient retention, temporal biomass constancy and roof temperature constancy. The diversity treatment included separate monocultures of 8 species in the community, randomly determined mixtures of 4 species, and a mixture of all 8. Functional groups included mosses, liverworts, colonial algae and a mycorrhizal inoculum. In a second experiment, between 1 and 4 of the functional groups were added to ...

2005-07-01

419

Nodular fasciitis: correlation of MRI findings and histopathology

Snake envenomation employs three well integrated strategies: prey immobilization via hypotension, prey immobilization via paralysis, and prey digestion. Purines (adenosine, guanosine and inosine) evidently play a central role in the envenomation strategies of most advanced snakes. Purines constitute the perfect multifunctional toxins, participating simultaneously in all three envenomation strategies. Because they are endogenous regulatory compounds in all vertebrates, it is impossible for any prey organism to develop resistance to them. Purine generation from endogenous precursors in the prey explains the presence of many hitherto unexplained enzyme activities in snake venoms: 5'-nucleotidase, endonucleases (including ribonuclease), phosphodiesterase, ATPase, ADPase, phosphomonoesterase, and NADase. Phospholipases A(2), cytotoxins, myotoxins, and heparinase also participate in purine liberation, in addition to their better known functions. Adenosine contributes to prey immobilization ...

2002-04-01

420

Optimizing the fMRI data-processing pipeline using prediction and reproducibility performance metrics: I. A preliminary group analysis.

Objective: To compare the histopathology of nodular fasciitis (NF) with the magnetic resonance imaging (MRI) findings in order to evaluate the basis of the MR signal characteristics. Design and patients: Ten patients with NF, nine females and 1 male, with an age ranging from 13 to 58 years (mean 26.8 years) were studied. MRI findings, available in all 10 patients, were compared with the histopathology in nine patients, and an area-to-area comparative study of the whole specimen section histopathology and MRI was performed in two patients. Results: On the basis of an excisional biopsy or resection specimen, the nine lesions were classified into myxoid (n=4), cellular (n=3) and fibrous (n=2) subtypes. Four myxoid lesions with a subcutaneous location showed a homogeneous SI comparable with muscle on T1-weighted images, high SI on T2-weighted images, and had homogeneous enhancement. One cellular lesion presented with homogeneous, slightly higher SI than muscle on T1-weighted images and ...

2002-03-01

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421

Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure.

We argue that published results demonstrate that new insights into human brain function may be obscured by poor and/or limited choices in the data-processing pipeline, and review the work on performance metrics for optimizing pipelines: prediction, reproducibility, and related empirical Receiver Operating Characteristic (ROC) curve metrics. Using the NPAIRS split-half resampling framework for estimating prediction/reproducibility metrics (Strother et al., 2002), we illustrate its use by testing the relative importance of selected pipeline components (interpolation, in-plane spatial smoothing, temporal detrending, and between-subject alignment) in a group analysis of BOLD-fMRI scans from 16 subjects performing a block-design, parametric-static-force task. Large-scale brain networks were detected using a multivariate linear discriminant analysis (canonical variates analysis, CVA) that was tuned to fit the data. We found that tuning the CVA model and spatial ...

2004-01-01

422

Effects of climate change on the production and consumption of electricity in Finland

The natriuretic peptides are considered to be cardioprotective; however, their receptors have not been identified in human myocardium using radiolabeled analogs. Dendroaspis natriuretic peptide (DNP) has been recently identified as a new member of this peptide family and is thought to be less susceptible to enzymatic degradation. Therefore, we have developed the novel radiolabeled analog [125I]-DNP and used this to localize high-affinity (K(D)=0.2 nmol/L), saturable, specific binding sites in adult human heart (n=6) and coronary artery (n=8). In competition binding experiments, atrial natriuretic peptide and brain type natriuretic peptide had greater affinity for [125I]-DNP binding sites than C-type natriuretic peptide and the natriuretic peptide receptor (NPR)-C ligand, cANF. This rank order of potency suggested binding of [125I]-DNP was specific to NPR-A. Messenger RNA encoding NPR-A was identified in left ventricle and coronary artery smooth muscle, and ...

2006-06-15

423

Effect of propylbenzilylcholine mustard on contraction and radioligand binding parameters of muscarinic receptors in guinea pig ileum

In the next few decades, the probable strengthening of the greenhouse effect may bring about considerable changes in energy production and consumption, which depend on climate. It is presumed that some of the changes will occur even if the rise in greenhouse gas concentration will be reduced. Because the investments in energy production have a long-term influence, decision-makers should have an idea about the impact of the strengthening of the greenhouse effect on energy production and consumption in Finland. According to the results of this study, the effects of climate change on the total consumption and production of electricity will be limited. The structure of both electricity consumption and production will remain rather similar, the most important changes applying to hydro power. The consumption of heating electricity will decrease substantially. Because the non- climate-dependent sectors of electricity consumption (process industry and services) account for more than a half of ...

1996-12-31

424

Direct photoaffinity labeling of gizzard myosin with ["3H]uridine diphosphate places Glu185 of the heavy chain at the active site

The receptor occupancy-biological effect relationship for muscarinic receptors in guinea pig ileal smooth muscle has been studied by comparison of radioligand binding and contractile response. Muscarinic receptors in homogenates of ileal smooth muscle were labeled with (/sub 3/H)-1-Quinuclidinyl benzilate. Treatment with propylbenzilylcholine mustard (PrBCM), to inactivate irreversibly muscarinic receptors, caused a large dose dependent rightward shift of the dose-response curve to three agonistic furtrethonium derivatives with a concomitant decrease in maximal response. Using those data, the fraction of receptors remaining unoccupied (q-values) and true affinity constants (-log K/sub A/-values) were calculated. Exposure to 20 or 60 nM PrBCM for 15 minutes resulted in a 39% and a 61% reduction in specific (/sup 3/H)-1-Quinuclidinyl benzilate binding sites respectively to be compared with a 62% and a 85% decrease expected from calculated ...

1987-10-26

425

Cytotoxic evaluation of N-isopropylacrylamide monomers and temperature-sensitive poly(N-isopropylacrylamide) nanoparticles

The active site of chicken gizzard myosin was labeled by direct photoaffinity labeling with ["3H]UDP. ["3H] UDP was stably trapped at the active site by addition of vanadate (Vi) and Co"2"+. The extraordinary stability of the myosin.Co2+.[3H]UDP.Vi complex (t1/2 greater than 5 days at 0 degrees C) allowed it to be purified free of extraneous ["3H]UDP before irradiation began. Upon UV irradiation, greater than 60% of the trapped ["3H]UDP was photoincorporated into the active site. Only the 200-kDa heavy chain was labeled, confirming earlier results using ["3H]UTP. Extensive tryptic digestion of photolabeled myosin subfragment 1 followed by high performance liquid chromatography separations and removal of nucleotide phosphates by treatment with alkaline phosphatase allowed two labeled peptides to be isolated. Sequencing of the labeled peptides and radioactive counting showed that Glu185 was the residue labeled. Since UDP is a zero-length cross-linker, Glu185 is located at the ...

426

cDNA sequence analysis of a 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolytica

The objective of this research project is to investigate the biocompatibility of N-isopropylacrylamide (NIPAAm) monomers and poly(N-isopropylacrylamide) (PNIPAAm) nanoparticles in vitro. PNIPAAm nanoparticles of different sizes were synthesized and characterized by transmission electron microscopy and dynamic light scattering. Cytotoxicity studies using MTS assays were conducted on fibroblasts, smooth muscle cells, and endothelial cells. In addition, the concentration of NIPAAm monomers remaining on PNIPAAm nanoparticles was determined using bromination and spectrophotometry. The cytotoxicity results did not show a significant difference in cell survival when cells were exposed to different particle sizes (100, 300, and 500 nm). Dose studies showed that all three cell types exposed to 100 nm PNIPAAm nanoparticles at concentrations less than or equal to 5 mg/mL were compatible, while cells exposed to NIPAAm monomers exhibited toxicity even at very low ...

2009-08-15

427

cDNA sequence analysis of a 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolytica

A {lambda}gt11 cDNA library was constructed from poly(U)-Spharose-selected Entamoeba histolytica trophozoite RNA in order to clone and identify surface antigens. The library was screened with rabbit polyclonal anti-E. histolytica serum. A 700-base-pair cDNA insert was isolated and the nucleotide sequence was determined. The deduced amino acid sequence of the cDNA revealed a cysteine-rich protein. DNA hybridizations showed that the gene was specific to E. histolytica since the cDNA probe reacted with DNA from four axenic strains of E. histolytica but did not react with DNA from Entamoeba invadens, Acanthamoeba castellanii, or Trichomonas vaginalis. The insert was subcloned into the expression vector pGEX-1 and the protein was expressed as a fusion with the C terminus of glutathione S-transferase. Purified fusion protein was used to generate 22 monoclonal antibodies (mAbs) and a mouse polyclonal antiserum specific for the E. histolytica portion of the fusion protein. ...

1990-08-01

428

Species comparison of acute inhalation toxicity of ozone and phosgene

A #lambda#gt11 cDNA library was constructed from poly(U)-Spharose-selected Entamoeba histolytica trophozoite RNA in order to clone and identify surface antigens. The library was screened with rabbit polyclonal anti-E. histolytica serum. A 700-base-pair cDNA insert was isolated and the nucleotide sequence was determined. The deduced amino acid sequence of the cDNA revealed a cysteine-rich protein. DNA hybridizations showed that the gene was specific to E. histolytica since the cDNA probe reacted with DNA from four axenic strains of E. histolytica but did not react with DNA from Entamoeba invadens, Acanthamoeba castellanii, or Trichomonas vaginalis. The insert was subcloned into the expression vector pGEX-1 and the protein was expressed as a fusion with the C terminus of glutathione S-transferase. Purified fusion protein was used to generate 22 monoclonal antibodies (mAbs) and a mouse polyclonal antiserum specific for the E. histolytica portion of the fusion protein. ...

429

Quantitative pharmacological analysis of 2-125I-iodomelatonin binding sites in discrete areas of the chicken brain

A comparison of the concentration-response effects of inhaled ozone (O/sub 3/) in different species of laboratory animals was made in order to better understand the influence of the choice of species in inhalation studies of this gas. The effect of 4-hour exposure to ozone (O/sub 3/) at concentrations of 0.0, 0.2, 0.5, 1.0, and 2.0 ppm was determined in rabbits, guinea pigs, rats, hamsters and mice. Lavage fluid protein (LFP) accumulation 18 hr after exposure was used as the indicator of O/sub 3/-induced pulmonary edema. All species had similar basal levels of LFP (250-350 ug/ml) when a volume of saline which approximated the total lung capacity was used for lavage of the collapsed lungs. Exponential dose-response curves were seen in all species except guinea pigs, which showed significant increases in LFP at low O/sub 3/ concentrations (0.2 ppm) and a leveling off of response at the higher O/sub 3/ levels. Other species usually showed significant elevations in LFP ...

1986-01-01

430

Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes.

The authors have localized and characterized 2-125I-iodomelatonin binding sites in the chicken brain using in vitro quantitative autoradiography. Binding sites were widely distributed throughout the chicken brain, predominantly in regions associated with the visual system. The specific binding of 2-125I-iodomelatonin to discrete chicken brain areas was found to be saturable, reversible, and of high affinity. The specific binding of 2-125I-iodomelatonin (75 pm) was quantitated for 40 identifiable brain regions. Eight brain regions were chosen for binding characterization and pharmacological analysis: optic tectum, Edinger-Westphal nucleus, oculomotor nucleus, nucleus rotundus, ventral supraoptic decussation, ventrolateral geniculate nucleus, neostriatum, and ectostriatum. These regions showed no rostral-caudal gradient in 2-125I-iodomelatonin specific binding, and saturation analysis revealed a single class of high-affinity sites with KD values in the range of 33-48 pM and receptor site ...

1991-09-01

431

MHC-like molecules in some nonmammalian vertebrates can be detected by some cross-reactive xenoantisera.

Previous investigations have shown that both the early biological response and the mechanical properties of a porous hydroxyapatite bone graft substitute are highly sensitive to its pore structure. The objective of this study was to evaluate whether the pore structure continued to influence bone integration in the medium to long term. Two screened batches of porous hydroxyapatite (PHA) designated as batch A and batch B, with porosities of approximately 60 and 80%, respectively, were selected for this study and implanted for periods of 5, 13, and 26 weeks into the lower femur of New Zealand White rabbits. Histomorphometric analysis of the absolute volume of bone ingrowth within batch A and B implants from 5 to 26 weeks showed that the absolute volume of bone ingrowth was consistently lower in batch A (10-21%), compared to batch B implants (24-31%). However, when the volume of bone ingrowth was normalised for the available pore space, this difference was reduced ...

2004-01-01

432

Large Scale Laser Two-Photon Polymerization Structuring for Fabrication of Artificial Polymeric Scaffolds for Regenerative Medicine

Rabbit antisera raised to human and chicken MHC molecules were used to immunoprecipitate cross-reactive molecules from biosynthetically and cell surface-labeled spleen and/or blood cells of representative vertebrate species. Five major points emerged: 1) There were many nonspecific cross-reactions using these techniques, so various criteria were developed to distinguish these from true MHC-like molecules. 2) Only very small subpopulations of immunogen-specific antibodies cross-reacted with MHC-like molecules in other nonmammalian species. These subpopulations were different for each species and even within a species, sometimes being so limited as to behave like alloantisera. This led to a very scattered pattern of true cross-reactions that sometimes failed to reflect the properties of the bulk antibody population. 3) Antisera containing antibodies to class II beta- and class I alpha-chains cross-reacted better and more widely than those to B-G, class II alpha and, ...

1990-01-01

433

Double-antibody solid-phase radioimmunoassay: a simplified phase-separation procedure applied to various ligands

We present a femtosecond Laser Two-Photon Polymerization (LTPP) system of large scale three-dimensional structuring for applications in tissue engineering. The direct laser writing system enables fabrication of artificial polymeric scaffolds over a large area (up to cm in lateral size) with sub-micrometer resolution which could find practical applications in biomedicine and surgery. Yb:KGW femtosecond laser oscillator (Pharos, Light Conversion. Co. Ltd.) is used as an irradiation source (75 fs, 515 nm (frequency doubled), 80 MHz). The sample is mounted on wide range linear motor driven stages having 10 nm sample positioning resolution (XY--ALS130-100, Z--ALS130-50, Aerotech, Inc.). These stages guarantee an overall travelling range of 100 mm into X and Y directions and 50 mm in Z direction and support the linear scanning speed up to 300 mm/s. By moving the sample three-dimensionally the position of laser focus in the photopolymer is changed and one is able to write complex 3D ...

2010-11-10

434

Double-antibody solid-phase radioimmunoassay: a simplified phase-separation procedure applied to various ligands

The purpose was to develop a simplified and reliable method of separating free from antibody-bound ligand using a precipitating antibody linked to a cellulose derivative. Dose-response curves and control sera were set up in parallel for various pituitary and placental polypeptides, steroid hormones, insulin, glucagon, triiodothyronine, thyroxine, angiotensin I, calcitonin, gastrin, cyclic AMP, and digoxin. After first-antibody reactions had reached equilibrium, free and bound ligand were separated using a double-antibody solid-phase system in parallel with conventional methods, including dextran-coated charcoal, double-antibody precipitation, single-antibody solid phase, organic solvents, salt precipitation, and anion-exchange resins. The effect of variations in temperature, incubation time, protein content, pH, and amount of separating material added were studied. The results showed that separation was complete within 1 hr for small ligand molecules and within 2 hr for larger ones. ...

1980-06-01

435

Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24

The purpose was to develop a simplified and reliable method of separating free from antibody-bound ligand using a precipitating antibody linked to a cellulose derivative. Dose-response curves and control sera were set up in parallel for various pituitary and placental polypeptides, steroid hormones, insulin, glucagon, triiodothyronine, thyroxine, angiotensin I, calcitonin, gastrin, cyclic AMP, and digoxin. After first-antibody reactions had reached equilibrium, free and bound ligand were separated using a double-antibody solid-phase system in parallel with conventional methods, including dextran-coated charcoal, double-antibody precipitation, single-antibody solid phase, organic solvents, salt precipitation, and anion-exchange resins. The effect of variations in temperature, incubation time, protein content, pH, and amount of separating material added were studied. The results showed that separation was complete within 1 hr for small ligand molecules and within 2 hr for larger ones. ...

436

Characterization of tris(N-substituted-2-methyl-3-hydroxy-4-pyridinonato)technetium(IV) cations

Duchenne and Becker muscular dystrophies are caused by defects of dystrophin, which forms a part of the membrane cytoskeleton of specialized cells such as muscle. It has been previously shown that the dystrophin-associated protein A1 (59-kDa DAP) is actually a heterogeneous group of phosphorylated proteins consisting of an acidic ({alpha}-A1) and a distinct basic ({beta}-A1) component. Partial peptide sequence of the A1 complex purified from rabbit muscle permitted the design of oligonucleotide probes that were used to isolate a cDNA for one human isoform of A1. This cDNA encodes a basic A1 isoform that is distinct from the recently described syntrophins in Torpedo and mouse and is expressed in many tissues with at least five distinct mRNA species of 5.9, 4.8, 4.3, 3.1, and 1.5 kb. A comparison of the human cDNA sequence with the GenBank expressed sequence tag (EST) data base has identified a relative from human skeletal muscle, EST25263, which is probably a human ...

1994-05-10

437

Characterization of tris(N-substituted-2-methyl-3-hydroxy-4-pyridinonato)technetium(IV) cations

A burgeoning interest in technetium coordination chemistry has been spurred by its widespread use in nuclear medicine. Recent focus has been on the design and preparation of new technetium complexes, the lipophilicity, polarity, and overall charge of which can be readily altered by simple substitutions in the molecular framework of the ligand in order to optimize the biodistribution and target specific organs. Examples are cationic (Cardiolite) and neutral (Ceretec) technetium complexes, used as myocardial and brain imaging agents, respectively. The authors have been pursuing a continuing study of tris(3-hydroxy-4-pyridinonato)gallium and -indium complexes that are water soluble, are hydrolytically stable, and are of varying lipophilicity and neutral charge. Studies of in vivo in rabbits and mice have revealed that several of these cationic complexes may be useful as morphologic kidney imaging agents, with [{sup 99m}Tc(pap){sub 3}]{sup +} showing elevated levels in ...

1994-11-23

438

Characterization of the major phosphoprotein and its kinase on the surface of the rat adipocyte

A burgeoning interest in technetium coordination chemistry has been spurred by its widespread use in nuclear medicine. Recent focus has been on the design and preparation of new technetium complexes, the lipophilicity, polarity, and overall charge of which can be readily altered by simple substitutions in the molecular framework of the ligand in order to optimize the biodistribution and target specific organs. Examples are cationic (Cardiolite) and neutral (Ceretec) technetium complexes, used as myocardial and brain imaging agents, respectively. The authors have been pursuing a continuing study of tris(3-hydroxy-4-pyridinonato)gallium and -indium complexes that are water soluble, are hydrolytically stable, and are of varying lipophilicity and neutral charge. Studies of in vivo in rabbits and mice have revealed that several of these cationic complexes may be useful as morphologic kidney imaging agents, with ["9"9"mTc(pap)_3]"+ showing elevated levels in the kidneys ...

439

Altered glycosaminoglycan metabolism in injured arterial wall

Intact rat fat cell exposed to 12.5 ..mu..M (..gamma..-32P)ATP incorporate label into specific proteins within minutes. By solubilizing the reaction mixture with SDS which bypasses the subcellular fractionation steps, the labeled proteins can be identified in autoradiographs of SDS-PAGE gels. The most prominently labeled protein has an M/sub r/ of 42,000. Localization of this component to the cell surface can be made on the basis of inhibition of phosphorylation by addition of a protein derived from the rat brain with protein kinase inhibitory property, susceptibility of the phosphorylated protein to the tryptic digestion, inhibition of phosphorylation of this protein after brief exposure to melittin. To rule out the possibility that the cell surface protein might be a mitochondrial contaminant from broken cells, /sup 32/Pi-labeled and (..gamma..-/sup 32/P)ATP-labeled cells were chromatographed on a rabbit anti-pyruvate dehydrogenase antibody-Sepharose 4B column. A ...

1986-12-01

440

A single amino acid substitution (R441A) in the receptor-binding domain of SARS coronavirus spike protein disrupts the antigenic structure and binding activity

Glycosaminoglycans (GAG) are believed to be important in the pathogenesis of atherosclerosis. We have previously demonstrated that areas of injured aorta that have been re-endothelialized accumulate increased amounts of lipid and GAG when compared to areas remaining de-endothelialized. We have now examined the net incorporation of labeled precursors into the individual GAG present in both re-endothelialized and de-endothelialized areas of rabbit aorta. Aortic tissue was examined at 2-3 and 10-14 weeks after a denuding injury by incubating tissue minces with (/sup 3/H)glucosamine and sodium (/sup 35/S)sulfate for 24 hr. Following incubation, the aortic GAG were isolated and assayed for uronic acid concentration and radioactivity. Results indicate that the total GAG concentration was significantly greater in the re-endothelialized as compared to de-endothelialized areas. The concentration in uninjured aorta was 9.01. The difference between the injured tissues was ...

1985-06-01

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441

A qualitative evaluation of radionuclide concentrations in Hanford Site Wildlife, 1983 through 1992

The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has two major functions: interacting with the receptor to mediate virus entry and inducing protective immunity. Coincidently, the receptor-binding domain (RBD, residues 318-510) of SAR-CoV S protein is a major antigenic site to induce neutralizing antibodies. Here, we used RBD-Fc, a fusion protein containing the RBD and human IgG1 Fc, as a model in the studies and found that a single amino acid substitution in the RBD (R441A) could abolish the immunogenicity of RBD to induce neutralizing antibodies in immunized mice and rabbits. With a panel of anti-RBD mAbs as probes, we observed that R441A substitution was able to disrupt the majority of neutralizing epitopes in the RBD, suggesting that this residue is critical for the antigenic structure responsible for inducing protective immune responses. We also demonstrated that the RBD-Fc bearing R441A mutation could not bind to soluble and ...

2006-05-26

442

166Ho-HA evaluation as therapeutic agent for rheumatoid arthritis treatment

Environmental monitoring has been conducted at the U.S. Department of Energy`s (DOE`s) Hanford Site in southeastern Washington State since 1945. Fish and wildlife have been monitored since 1945, however, a major emphasis on mammals did not occur until the 1970s. This report focuses on the 10-year period from 1983 through 1992. The objectives of this report are to evaluate {sup 90}Sr and {sup 137}Cs concentrations in Site wildlife populations and, when possible, evaluate trends in concentrations over this period of time. No distinct trends in radionuclide concentrations were apparent in most species sampled. Many measurements were at or below the analytical limit of detection. This evaluation found that concentrations of {sup 90}Sr in rabbit and deer bone were elevated in animals collected from areas adjacent to industrialized areas. Similarly, radionuclide concentrations in duck muscle from waterfowl collected at B Pond were elevated with {sup 137}Cs when compared ...

1994-10-01

443

A study of flow boiling phenomena using real time neutron radiography

Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This leads to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate "1"6"6Ho-Hydroxyapatite ("1"6"6 Ho-HA) as potential radiopharmaceutical for the symptomatic treatment of chronic and acute arthritis. Materials and Methods: Holmiun-166 was produced by irradiation of Ho_2O_3 at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthesized. Its labelling and quality controls follows the internationally accepted procedures. An antigen's arthritis was induced to eight New Zealand rabbits with the "1"6"6 Ho-HA radiochemical being administered thereafter in two dosage modalities (single and double). The compound therapeutic efficiency was evaluated based upon ...

2002-09-01

444

Vibration signature analysis of AFM images

The operation and safety of both fossil-fuel and nuclear power stations depend on adequate cooling of the thermal source involved. This is usually accomplished using liquid coolants that are forced through the high temperature regions by a pumping system; this fluid then transports the thermal energy to another section of the power station. However, fluids that undergo boiling during this process create vapor that can be detrimental, and influence safe operation of other system components. The behavior of this vapor, or void, as it is generated and transported through the system is critical in predicting the operational and safety performance. This study uses two advanced penetrating radiation techniques, Real Time Neutron Radiography (RTNR), and High Speed X-Ray Tomography (HS-XCT), to examine void generation and transport behavior in a flow boiling system. The geometries studied were tube side flow boiling in a cylindrical configuration, and a similar flow channel with an internal ...

1346-01-01

445

Turbulent heat transfer augmentation using microscale disturbances inside the viscous sublayer

Vibration signature analysis has been commonly used for the machine condition monitoring and the control of errors. However, it has been rarely employed for the analysis of the precision instruments such as an atomic force microscope (AFM). In this work, an AFM was used to collect vibration data from a sample positioning stage under different suspension and support conditions. Certain structural characteristics of the sample positioning stage show up as a result of the vibration signature analysis of the surface height images measured using an AFM. It is important to understand these vibration characteristics in order to reduce vibrational uncertainty, improve the damping and structural design, and to eliminate the imaging imperfections. The choice of method applied for vibration analysis may affect the results. Two methods, the data dependent systems (DDS) analysis and the Welch`s periodogram averaging method were investigated for application to this problem. Both techniques provide ...

1995-12-31

446

Turbulent heat transfer augmentation and friction in periodic fully developed channel flows

The authors report here on an experimental study of heat transfer augmentation in turbulent flow. Enhancement strategies employed in this investigation are based on the near-wall mixing processes induced in the sublayer through appropriate wall and near-wall streamwise-periodic disturbances. Experiments are performed in a low-turbulence wind-tunnel with a high-aspect-ratio rectangular channel having either (a) two-dimensional periodic microgrooves on the wall, or (b) two-dimensional microcylinders placed in the immediate vicinity of the wall. It is found that microdisturbances placed inside the sublayer induce favorable heat-transport augmentation with respect to the smooth-wall case, in the near-analogous momentum and heat transfer behavior are preserved; a roughly commensurate increase in heat and momentum transport is termed favorable in that it leads to a reduction in the pumping power penalty at fixed heat removal rate. The study shows that this favorable ...

1992-05-01

447

The B-L/Electroweak Hierarchy in Smooth Heterotic Compactifications

Measurements are presented of the distribution of average friction factors (f) as well as local and average ({ovr Nu}) heat transfer coefficients for fully developed channel flows with two rib-roughened opposite walls. The temperature measurements were made by using both a laser holographic interferometer and thermocouples. In addition, the reattachment length was determined by flow visualization. The Reynolds number (Re) was varied from 5.0 {times} 10{sup 3} to 5.4 {times} 10{sup 4}; the rib pitch-to-height ratios (Pi/H) were 10, 15, 20; and the rib height-to-hydraulic diameter ratios (H/De) were 0.063, 0.081, and 0.106. The detailed results allowed the peaks of heat transfer augmentation and the regions susceptible to hot spots to be located and allowed the relative contribution of the rib surface and the channel wall to the heat transfer augmentation to be determined. Moreover, relative to a smooth duct, the enhancement of both {ovr Nu} and f at various Re, ...

1992-02-01

448

Study on a recovery of rare earth oxides from a LiCl-KCl-RECl3 system

E8 X E8 heterotic string and M-theory, when appropriately compactified, can give rise to realistic, N=1 supersymmetric particle physics. In particular, the exact matter spectrum of the MSSM, including three right-handed neutrino supermultiplets, one per family, and one pair of Higgs-Higgs conjugate superfields is obtained by compactifying on Calabi-Yau manifolds admitting specific SU(4) vector bundles. These "heterotic standard models" have the SU(3)_{C} X SU(2)_{L} X U(1)_{Y} gauge group of the standard model augmented by an additional gauged U(1)_{B-L}. Their minimal content requires that the B-L gauge symmetry be spontaneously broken by a vacuum expectation value of at least one right-handed sneutrino. In a previous paper, we presented the results of a renormalization group analysis showing that B-L gauge symmetry is indeed radiatively broken with a B-L/electroweak hierarchy of O(10) to O(10^{2}). In this paper, we present the details of that analysis, extending the results to ...

2009-01-01

449

British Library Electronic Table of Contents (United Kingdom)

Radioactive rare earth chlorides in waste LiCl-KCl molten salts have to be separated as a stable form to minimize waste volume and to achieve stable solidification. In this work, thermal behavior of rare earth chlorides (CeCl3, GdCl3, NdCl3, PrCl3) was investigated in an oxygen condition to recover rare earth oxides from a LiCl-KCl-RECl3 system. The rare earth chlorides in the LiCl-KCl molten salts were smoothly converted to an oxychloride form at a higher temperature than 650degreeC, except for CeCl3. CeCl3 was totally converted to an oxide from at a higher temperature than 450degreeC. The rare earth oxychlorides (GdOCl, NdOCl, PrOCl) were effectively converted to oxide forms at a higher temperature than 1100degreeC. It was confirmed that rare earth oxides can be recovered from a LiCl-KCl...

2011-01-01

450

Studies of wind profile and estimation of surface layer scaling parameters for the coastal site of Tarapur

Some highlights of phase-C commissioning of Tarapur-4 the first to be synchronized 540 MWe PHWR

This paper presents the directional dependence of surface scaling parameters namely roughness length and corresponding friction velocity, for neutral category of Tarapur coastal site. The average roughness length of lowest value of 0.07 m (SW) and the highest value of 0.32 m (E) and average friction velocity of lowest value 1.6 m/sec(SSE) and a highest value 2.8 m/sec (SW) for the year 2006 were observed. Wind profile studies for the coastal site Tarapur with the wind data measured from meteorological tower of 30m which is at 1500m downwind fetch distance from the coastal line in the east direction gave the wind profile index parameter 'p' as 0.4, 0.5 and 0.75 for Unstable, Neutral and Stable weather conditions respectively. Sector Average Turbulent kinetic energy estimated as 17.7m2/s2 and its dissipation rate is 3.1 m2/s3 for the 10m elevation from the surface. A surface drag coefficient CD for the 10m height is 0.0076 for the smooth ocean surface and 0.0107 for ...

2007-06-05

451

Selective patterned growth of single-crystal organic nanowires of Ag-TCNQ with chemical raction method

Commissioning of a Pressurized heavy water reactor (PHWR) plant of NPCIL involves three phases viz phase-A which consist of pre-criticality activities such as hydro test, air hold test, no load test of motors etc., phase-B consist of criticality and post criticality physics experiments. The phase-C, which is considered the major phase, consist of initial power raise to about 10 % , TG rolling, synchronization, going to significant power in steps and performance tests such as load rejection tests from various power levels. In order to have smooth commissioning for the Phase-C, an integrated team consisting of engineers from various design and analysis groups of NPCIL headquarters was formed to participate along with site O and M engineers, closely observe and coordinate phase-C commissioning activities. During this commissioning some major events and observations took place. An attempt is made to bring out the salient observations of Tarapur-4 Phase-C commissioning. ...

2006-11-13

452

Progress at LAMPF, 1992--1993

Abstract: We report for the selective-area chemical synthesis of semiconductor single-crystal organic nanowires of silver-tetracyanoquinodimethane (Ag-TCNQ). Straight and smooth Ag-TCNQ nanowires can be produced and patterned on micrometer and nanometer scale on silicon substrates covered with a thin layer of Ag film through the reaction of TCNQ and Ag in a simple gas-solid chemical reaction process. Ag-TCNQ nanowires are characterized by UV-vis, IR and Raman spectroscopy, respectively. The Ag-TCNQ nanowires grows preferentially along the [100] direction of strong - stacking of Ag-TCNQ molecules. Nanodevices based on these nanowires are fabricated using focus ion beam (FIB) technique. Electrical properties are characterized and I-V hysteresis is observed, which shows memory effect with electrical switching of three orders on-off ratio. These nanowires could be potential for use in optical storage, ultrahigh-density nanoscale memory and logic devices.

2008-09-01

453

Programmed improvements of the alternating gradient synchrotron complex at Brookhaven National Laboratory, Upton, New York. Environmental assessment

This Progress Report describes the operation of the Los Alamos Meson Physics Facility (LAMPF) and the research programs carried out there for the years 1992 and 1993. The accelerator operated for over 100 days in 1992, providing beams of H{sup +}, H{sup {minus}}, and polarized H{sup {minus}} for a rich and varied research program in nuclear physics. The accelerator had only fair beam availability in 1992 (for example, the average H{sup +} beam availability was 72%), caused largely by problems in the 201-MHz rf system. A major effort was expended to address these problems before the 1993 run. These efforts were rewarded by good beam availability in 1993 and few problems with the 201-MHz system. LAMPF operated remarkably smoothly during 1993, in the midst of a period of great uncertainty in the future of the facility and the downsizing of MP Division, which led to the loss of a large number of key people to positions elsewhere in the Laboratory. The H{sup +} ...

1994-07-25

454

Principe local-global pour les z\\'ero-cycles sur certaines fibrations au-dessus d'une courbe: II

The purpose and need for DOE to undertake the actions described in this document are to improve the efficiency of the Alternating Gradient Synchrotron (AGS) complex. Benefits would include optimization of the AGS scientific program, increased high-energy and nuclear physics experimentation, improved health and safety conditions for workers and users, reduced impact on the environment and the general public, energy conservation, decreased generation of hazardous and radioactive wastes, and completion of actions required to permit the AGS to be the injector to the Relativistic Heavy Ion Collider (RHIC)., Improved efficiency is defined as increasing the AGS`s capabilities to capture and accelerate the proton intensity transferred to the AGS from the AGS booster. Improved capture of beam intensity would reduce the beam losses which equate to lost scientific opportunity for study and increased potential for radiation doses to workers and the general public. The action would also refurbish ...

1994-03-01

455

Preparation and characterization of iron oxide thin films by spray pyrolysis using methanolic and ethanolic solutions

We consider an admissible fibration $\\pi:X\\to\\mathbb{P}^1$ over a curve over a number field, of which the generic fiber $X_\\eta$ is geometrically rationally connected. We suppose that there exists a generalized Hilbertian subset $\\textsf{Hil}$ of $\\mathbb{P}^1$, such that the Brauer-Manin obstruction is the only obstruction to the Hasse principle (resp. to the weak approximation) for $X_\\theta(\\theta\\in \\textsf{Hil}).$ We prove that the Brauer-Manin obstruction is the only obstruction to the Hasse principle (resp. to the strong approximation) for zero-cycles of degree 1 on $X$ in the following cases: $(B_1)$ the index of the generic fibre $X_\\eta$ is equal to 1; $(B_2)$ all fibers are geometrically integral. Then, we obtain some similar results for certain fibrations over $\\mathbb{P}^n$. As a consequence, we obtain the following result: let $X$ be a smooth projective geometrically rationally connected variety over a number field $k$, if the Brauer-Manin ...

2010-01-01

456

Preclinical evidence for the benefits of penile rehabilitation therapy following nerve-sparing radical prostatectomy.

Iron oxide thin films have been obtained by spray pyrolysis using 100% methanolic and ethanolic solutions of iron tri-chloride. The films were deposited onto ITO-coated glass substrates. The preparative conditions have been optimized to obtain compact, pin-hole-free and smooth thin films which are adherent to the substrate. The structural, morphological and compositional characterizations have been carried out by X-ray diffraction, scanning electron microscopy and energy dispersive X-ray analysis. The films deposited using ethanolic solution results into pure hematite; #alpha#-Fe_2O_3 thin films, however, films deposited using methanolic solution consists of hematite and maghemite-c phases of iron oxide. The films are nanocrystalline with particle size of 30-40 nm. The optical absorbance of the film was of the order of 10"5 cm"-"1. The optical band gap of films was found to be 2.26 and 2.20 eV for the films deposited using methanolic and ethanolic solutions, ...

2006-01-15

457

Physical properties of Ti/sub 50/Be/sub 40/Zr/sub 10/ glass

Erectile dysfunction following radical prostatectomy remains a frequent problem despite the development of nerve-sparing techniques. This erectile dysfunction is believed to be neurogenic, enhanced by hypoxia-induced structural changes which result in additional veno-occlusive dysfunction. Recently, daily use of intracavernous vasoactive substances and oral use of PDE5-inhibitors have been clinically studied for treatment of postprostatectomy erectile dysfunction. Since these studies showed benefits of "penile rehabilitation therapy," these effects have been studied in a preclinical setting. We reviewed experimental literature on erectile tissue preserving and neuroregenerative treatment strategies, and found that preservation of the erectile tissue by the use of intracavernous nitric oxide donors or vasoactive substances, oral PDE5-inhibitors, and hyperbaric oxygen therapy improved erectile function by antifibrotic effects and preservation of smooth muscle. ...

2008-01-01

458

Performance characteristics of a natural circulation cooling/latent heat storage system

Continuous metallic glass ribbons were produced by mejans of liquid-quenching at rates >10/sup 50/C/s. The ribbons, typically 30 ..mu..m thick and 1 to 2 mm wide, were determined to be glassy by X-ray diffraction (XRD) employing CuK..cap alpha.. and MoK..cap alpha.. radiation. Mechanical properties of the as-quenched product were determined by measurements of hardness, tensile strength and Young's modulus. The Vicker's diamond pyramid microhardness (H/sub V/) was measured on epoxy mounted samples using a Lietz Miniload instrument with a 100 g load. Tensile tests were conducted in an Instron machine using specimens which were hand-polished to produce smooth, parallel sides. Young's modulus (E) is given by the relationship rho V/sub E/sup 2//. V/sub E/, the velocity of extensional mode waves, was measured by the pulse-echo technique using a Panametrics Intervalometer and glass density, rho, was obtained by the liquid immersion method. ...

1977-09-01

459

Paul Trap Simulator Experiment to Model Intense Beam Propagation in Alternating-gradient Transport Systems

A cooling system was developed which could be used even in such areas where the maximum and minimum temperatures of a day might differ widely. The system features in that a latent heat storage unit is connected to the natural circulation cooling unit consisting of 2 heat exchangers where condensed gas (refrigerant) which performs gas-liquid change has been sealed, enabling to cool objects night and day without the requirement for any power source. Electronic equipment was installed in an insulated shelter. Lauric acid and refrigerant R-22 were used as the latent heat storage medium and the heat transport medium respectively. Natural convection heat transfer performance of the outside surfaces of the condenser and the evaporator and the transient behavior of the system during the melting and solidification periods of the latent heat storage medium were tested. As a result of a 48 hour simulation experiment with load conditions set basing on the result of load computation, ...

1987-09-25

460

Optical properties of rare earth sodium double molybdates Na[sub 5]RE(MoO[sub 4])[sub 4], RE=Pr, Nd, Eu

The results presented here demonstrate that the Paul Trap Simulator Experiment (PTSX) simulates the propagation of intense charged particle beams over distances of many kilometers through magnetic alternating-gradient (AG) transport systems by making use of the similarity between the transverse dynamics of particles in the two systems. Plasmas have been trapped that correspond to normalized intensity parameters s = wp2 (0)/2wq2 * 0.8, where wp(r) is the plasmas frequency and wq is the average transverse focusing frequency in the smooth-focusing approximation. The measured root-mean-squared (RMS) radius of the beam is consistent with a model, equally applicable to both PTSX and AG systems that balances the average inward confining force against the outward pressure-gradient and space-charge forces. The PTSX device confines one-component cesium ion plasmas for hundreds of milliseconds, which is equivalent to over 10 km of beam propagation.

2004-01-29

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

Nuclear mass prediction as an image reconstruction problem: can observed pattern determine mass values?

Absorption and emission measurements at liquid-helium temperature, liquid-nitrogen temperature and room temperature have been performed on tetragonal scheelite-type rare earth sodium double molybdates Na[sub 5]RE(MoO[sub 4])[sub 4] and on RE-doped Na[sub 5]Gd(MoO[sub 4])[sub 4] samples. The rare earth occupies one single crystallographic position with S[sub 4] as point symmetry. The spectra were analysed according to the crystal field theory. From the experimental data, nearly complete energy level schemes of the Pr[sup 3+] and Nd[sup 3+], on the 4f [sup 2] and 4f [sup 3] configurations were derived. Very good correlation was obtained between the experimental and simulated energy level schemes, first for the approximated D[sub 2d] and then for the true S[sub 4] symmetries. The crystal field parameters vary smoothly with the atomic number of the rare earth, when compared with those determined previously for Eu[sup 3+] in the same matrix. ((orig.))

1994-06-01

462

Nuclear mass prediction as an image reconstruction problem: can observed pattern determine mass values?

Theoretical prediction of nuclear masses is analyzed as a pattern recognition problem on the N-Z plane. A global pattern is observed by plotting the differences between measured masses and Liquid Drop Model (LDM) predictions. After unfolding the data by removing the smooth LDM mass contributions, the remaining microscopic effects have proved difficult to model, although they display a striking pattern. These deviations carry information related to shell closures, nuc]ear deformation and the residual nuclear interactions. In the present work the more than 2000 known nuclear masses are studied as an array in the N-Z plane viewed through a mask, behind which the approximately 7000 unknown unstable nuclei that can exist between the proton and neutron drip lines are hidden. We show here that employing a Fourier transform deconvolution method these by masses can be predicted with similar accuracy than standard methods. We believe that a more general approach needs to be ...

2006-07-01

463

Newtonian hydrodynamics of the coalescence of black holes with neutron stars IV Irrotational binaries with a soft equation of state

Theoretical prediction of nuclear masses is analyzed as a pattern recognition problem on the N-Z plane. A global pattern is observed by plotting the differences between measured masses and Liquid Drop Model (LDM) predictions. After unfolding the data by removing the smooth LDM mass contributions, the remaining microscopic effects have proved difficult to model, although they display a striking pattern. These deviations carry information related to shell closures, nuc]ear deformation and the residual nuclear interactions. In the present work the more than 2000 known nuclear masses are studied as an array in the N-Z plane viewed through a mask, behind which the approximately 7000 unknown unstable nuclei that can exist between the proton and neutron drip lines are hidden. We show here that employing a Fourier transform deconvolution method these by masses can be predicted with similar accuracy than standard methods. We believe that a more general approach needs to be ...

464

Natural gas the new locomotive fuel

We present the results of three-dimensional hydrodynamical simulations of the final stages of inspiral in a black hole-neutron star binary, when the separation is comparable to the stellar radius. We use a Newtonian Smooth Particle Hydrodynamics (SPH) code to model the evolution of the system, and take the neutron star to be a polytrope with a soft (adiabatic index G=2 and G=5/3) equation of state and the black hole to be a Newtonian point mass. The only non-Newtonian effect we include is a gravitational radiation back reaction force, computed in the quadrupole approximation for point masses. We use irrotational binaries as initial conditions for our dynamical simulations, which are begun when the system is on the verge of initiating mass transfer and followed for approximately 23 ms. For all the cases studied we find that the star is disrupted on a dynamical time-scale, and forms a massive (the disc mass is approximately 0.2 solar masses) accretion torus around ...

2001-01-01

465

Morphology and thermal properties of electrospun fatty acids/polyethylene terephthalate composite fibers as novel form-stable phase change materials

This is a report on modification of a locomotive diesel engine to a dual-fuel engine to determine if the dual fuel engine in railway service will provide high performance, lower fuel and maintenance costs. After the locomotive was modified and the new governor and linkage were installed by General Motors at the BN's Northtown Diesel Shop near Minneapolis, the locomotive went through startup procedures. General Motors participated in startup. Some calibration, adjustments and minor piping changes were required but in general the problems encountered in startups were quite insignificant. The locomotive was connected to the load box (static test) during startup and at 720 RPM exceeded the required output for this test as established by the parties. Operation on straight oil over the range from idle through No. 8 throttle notch and on dual fuel from No. 5 through No. 8 throttle notch was smooth as was the transfer from oil to gas and from gas to oil. The ...

1984-01-01

466

Morphology and luminescence properties of ZnO layers produced by magnetron spattering

The ultrafine fibers based on the composites of polyethylene terephthalate (PET) and a series of fatty acids, lauric acid (LA), myristic acid (MA), palmitic acid (PA), and stearic acid (SA), were prepared successfully via electrospinning as form-stable phase change materials (PCMs). The morphology and thermal properties of the composite fibers were studied by field emission scanning electron microscopy (FE-SEM) and differential scanning calorimetry (DSC), respectively. It was found that the average fiber diameter increased generally with the content of fatty acid (LA) in the LA/PET composite fibers. The fibers with the low mass ratio maintained cylindrical shape with smooth surface while the quality became worse when the mass ratio is too high (more than 100/100). Moreover, the latent heat of the composite fibers increased with the increase of LA content and the phase transition temperature of the fibers have no obvious variations compared with LA. In contrast, ...

2008-11-15

467

Modeling the Galactic CV Distribution for the ChaMPlane Survey

We show that the morphology and the luminescence properties of ZnO layers produced by magnetron sputtering can be controlled by technological parameters of sputtering, particularly by the ratio of argon to oxygen gases in the gas flow during the growth process. Smooth and flat layers were produced with a high Ar/O ratio, while porous layers with various morphologies were obtained with a low Ar/O ratio. The layers produced with O/Ar ration equal to 10 exhibit extremely high near-bandgap luminescence intensity even higher in comparison with bulk ZnO single crystals. The free carrier density estimated from the analysis of photoluminescence spectra is also very high in these samples suggesting that these technological conditions promote both optical and electrical activation of the doping Al impurity. The samples grown with high Ar/O ratios exhibit strong visible emission which is controlled by the technological conditions.

2011-07-07

468

Magnetic resonance appearance of peripheral nerve sheath tumors

For purposes of designing targeted cataclysmic variable (CV) detection surveys and interpreting results of other projects with many CV detections such as the ChaMPlane Survey, we have created a model of the CV distribution in the Galaxy. It is modeled as a warped, flared exponential disk with a gaussian vertical distribution. Extinction is based on a detailed Galactic dust and gas model. A luminosity function for CVs is also incorporated, based on a smoothed version of published data. We calculate predicted field detection rates as a function of the limiting magnitude expected for the detecting system (i.e. WIYN/Hydra or NOAO 4m/Mosaic). Monte-Carlo techniques are used to assess statistical fluctuations in these rates. We have created maps of the expected CV distribution for the full non-bulge Galactic plane (20

2007-01-01

469

Localized tachyons in C{sup 3}/Z{sub N}

Magnetic resonance imaging (MRI) was used to evaluate 22 histological proven peripheral nerve sheath tumors, approximately two-thirds of which arose in the lower extremity. The histologic distribution was as follows: 12 schwannomas, 7 neurofibromas, and 3 malignant peripheral nerve sheath tumors (2 of which occurred in patients with neurofibromatosis). Most lesions demonstrated an intermediate to moderately bright signal on T_1-weighted images and were minimally inhomogeneous. All lesions were moderately bright on T_2-weighted images, again with variable inhomogeneity. The extent of the tumor was best assessed on proton-density- and T_2-weighted images. Smooth margins were noted in 19 lesions. Of the 3 remaining lesions, 2 were malignant (but had been subjected to biopsy prior to MRI), and the other lesion was a plexiform neurofibroma. MRI accurately determined the relationship between the lesions and the adjacent neurovascular structures and muscles, thereby ...

470

Local therapies to heal the penis: fact or fiction?

We study the condensation of localized closed string tachyons in C{sup 3}/Z{sub N} non-supersymmetric noncompact orbifold singularities via renormalization group flows that preserve supersymmetry in the worldsheet conformal field theory and their interrelations with the toric geometry of these orbifolds. We show that for worldsheet supersymmetric tachyons, the endpoint of tachyon condensation generically includes 'geometric' terminal singularities (orbifolds that do not have any marginal or relevant Kahler blowup modes) as well as singularities in co-dimension two. Some of the various possible distinct geometric resolutions are related by flip transitions. For Type II theories, we show that the residual singularities that arise under tachyon condensation in various classes of Type II theories also admit a Type II GSO projection. We further show that Type II orbifolds entirely devoid of marginal or relevant blowup modes (Kahler or otherwise) cannot exist, which thus ...

2004-08-01

471

Penile rehabilitation has been an area of intense study and debate over the last decade. Interest in this topic was stimulated by the observation that erectile dysfunction remained a significant problem after radical prostatectomy despite meticulous nerve-sparing technique. Smooth muscle alterations and fibrotic changes in the penis were identified as the underlying causes of penile atrophy, veno-occlusive dysfunction, and Peyronie's-like changes that were observed after surgery. Initial observations that intracavernous injection therapies used on a regular basis postoperatively resulted in improvements in the return of spontaneous erectile function led to the development of penile rehabilitation protocols. Chronic dosing of oral type V phosphodiesterase inhibitors is now commonly used by urologists after radical prostatectomy despite a lack of convincing evidence from randomized, placebo-controlled clinical trials. Use of local therapies to heal the penis may have ...

2008-11-20

472

Hydrogen combustion and exhaust emissions in a supercharged gas engine ignited with micro pilot diesel fuel

Nano-wire arrays of Niobium were produced by small angle sputtering on facetted sapphire, using the self shadowing effect of the facets. A wire width of about 80 nm was adjusted, the mean (maximum) wire height was about 20 nm (30 nm), the length can be in the cm range. Meander-film morphologies of 20 nm mean (26 nm maximum) thickness were produced by conventional sputtering onto smooth sapphire substrates at elevated temperatures. The morphology of the wires was investigated with atomic force microscopy (AFM), using contact mode. Meander-films were studied by scanning tunnelling microscopy (STM). Hydrogen loading was performed by instantaneously increasing the hydrogen gas pressure above the solubility limit. Thus, an elongated hydride could be monitored in an about 30 nm thick wire. STM studies on meander-films show the presence of cylindrical hydrides. Local out-of-plane and in-plane expansion can be explained by the formation of hydrides, being coherent with the ...

2007-10-31

473

Hybrid electric vehicles and electrochemical storage systems - a technology push-pull couple

A hydrogen combustion and exhaust emissions in a supercharged gas engine ignited with micro pilot diesel fuel was discussed in this presentation. A schematic diagram of the experimental study was first presented. The single cylinder, water-cooled, supercharged test engine was illustrated. Results were presented for the following: fuel energy and energy share (hydrogen and diesel fuel); pressure history and rate of heat release; engine performance and exhaust emissions; effect of nitrogen dilution on heat value per cycle; effect of N_2 dilution on pressure history and rate of heat release; and engine performance and exhaust emissions. This presentation demonstrated that smooth and knock-free engine operation results from the use of hydrogen in a supercharged dual-fuel engine for leaner fuel-air equivalence ratios maintaining high thermal efficiency. It was possible to attain mor3 than 90 per cent hydrogen-energy substitution to the diesel fuel with zero smoke ...

2009-09-20

474

HST/ACS observations of shell galaxies: inner shells, shell colours and dust

In the advance of fuel cell electric vehicles (EV), hybrid electric vehicles (HEV) can contribute to reduced emissions and energy consumption of personal cars as a short term solution. Trade-offs reveal better emission control for series hybrid vehicles, while parallel hybrid vehicles with different drive trains may significantly reduce fuel consumption as well. At present, costs and marketing considerations favor parallel hybrid vehicles making use of small, high power batteries. With ultra high power density cells in development, exceeding 1 kW/kg, high power batteries can be provided by adapting a technology closely related to consumer cell production. Energy consumption and emissions may benefit from regenerative braking and smoothing of the internal combustion engine (ICE) response as well, with limited additional battery weight. High power supercapacitors may assist the achievement of this goal. Problems to be solved in practice comprise battery management to ...

1999-12-01

475

Free electron laser experiments using a long pulse induction linac

AIM:Learn more about the origin of shells and dust in early type galaxies. METHOD: V-I colours of shells and underlying galaxies are derived, using HST Advanced Camera for Surveys (ACS) data. A galaxy model is made locally in wedges and subtracted to determine shell profiles and colours. We applied Voronoi binning to our data to get smoothed colour maps of the galaxies. Comparison with N-body simulations from the literature gives more insight to the origin of the shell features. Shell positions and dust characteristics are inferred from model galaxy subtracted images. RESULT: The ACS images reveal shells well within the effective radius in some galaxies (at 1.7 kpc in the case of NGC 5982). In some cases, strong nuclear dust patches prevent detection of inner shells. Most shells have colours which are similar to the underlying galaxy. Some inner shells are redder than the galaxy. All six shell galaxies show out of dynamical equilibrium dust features, like lanes or ...

2007-01-01

476

Formation of ZnTe compounds by using the electrochemical ion exchange reaction in molten chloride

The NRL Long Pulse Induction Linac is being employed in a Free Electron Laser (FEL) experiment. The authors present results of beam transport and focusing experiments as well as measurements of the output radiation generated by various magnetic wigglers. The electron gun of the accelerator presently has a 17-cmdiam. cold cathode which is located in a nearly zero magnetic field (B /SUB z/ less than or equal to 5 G). The gun voltage is flat to within approx. = + or - 5% for 1.5 #mu#sec with this graphite brush cathode. The beam is focused by a series of solenoidal coils as it propagates through the 4-m-long accelerator."2 A solenoidal field which can be varied from 1-10 kG confines the beam in the FEL interaction region. Previous experiments were limited by poor beam transport, focusing, and matching into the relatively large solenoidal field in the FEL region. By smoothing the axial magnetic field profile in the accelerator and making a more adiabatic transition ...

477

Final phase testing and evaluation of the 500 kW direct contact pilot plant at East Mesa

The formation of ZnTe films was investigated on zinc substrates at 640 K by using the following ion exchange and chemical reaction processes,2Zn{sub (substrate)}+Te{sup 4+}{sub (inmoltensalts)}->2Zn{sup 2+}+Te{sub (onsubstrate)}Zn{sub (substrate)}+Te= {sub (onsubstrate)}-> ZnTe{sub (onsubstrate)}The Te{sup 4+} species was supplied to the substrate via the gas phase, vaporized from the eutectic LiCl-KCl molten salt containing TeCl{sub 4} (0.05-0.9 mol%). The phase of the films obtained depended on the reaction time and the TeCl{sub 4} content in the molten chloride. At low TeCl{sub 4} concentrations, ZnTe alloy was not formed over the entire surface even after 3.6 ks. On the other hand, at high TeCl{sub 4} concentrations, tellurium was detected in addition to the ZnTe compound during the first 0.3 ks of the reaction. By selecting appropriate TeCl{sub 4} concentrations and reaction times, a ZnTe film with a smooth, dense surface was obtained. The ...

2005-05-01

478

Feasibility of subcriticality and NDA measurements for spent fuel by frequency analysis techniques with {sup 252}Cf

The testing performed during the last phase of the geothermal direct contact heat exchanger program utilizing the 500 kW pilot plant provided more insight into the capabilities and limits of the direct contact approach and showed that more work needs to be done to understand the inner workings of a large direct contact heat exchanger if they are to be modeled analytically. Testing of the column demonstrated that the performance was excellent and that the sizing criteria is conservative. The system operated smoothly and was readily controlled over a wide range of operating conditions. Performance evaluation showed pinch differentials of 4/sup 0/F or less and better than predicted heat transfer capability. Testing during this final phase was directed towards establishing the limits of the column to transfer heat. The working column height was shortened progressively to approximately 16 feet from a design length of 28 feet. The short column performed as well as a full ...

1983-12-01

479

Factorization scheme analysis of $F_{2}^{\\gamma}(x,Q^{2})$ and parton distributions functions of the photon

The {sup 252}Cf-source-driven frequency analysis method can be used for measuring the subcritical neutron multiplication factor of arrays of LWR fuel and as little as a single PWR fuel assembly. These measurements can be used to verify the criticality safety margins of spent LWR fuel configurations and thus could be a means of obtaining the information to justify burnup credit for spent LWR transportation/storage casks. In addition, the data can be used to validate calculational methods for criticality safety. These measurements provide parameters that have a higher sensitivity to changes in fissile mass than neutron multiplication factor and thus serve as a better test of calculational methods. The analysis have also shown that measurement of the cross power spectral density (CPSD) between detectors on one side of a single fuel assembly and an internal or external {sup 252}Cf source driving the fission chain multiplication process can be used for nondestructive assay of fissile mass ...

1996-05-01

480

Fabrication of single nanofluidic channels in poly(methylmethacrylate) films via focused-ion beam milling for use as molecular gates

Complete factorization scheme analysis of $F_2^{\\gamma}(x,Q^2)$ in the next--to--leading order QCD is performed. It is shown that the presence of the inhomogenous term in the evolution equations for parton distribution functions of the photon implies qualitative change in the way factorization mechanism works in photon--hadron and photon--photon collisions as compared to hadron--hadron ones. The incompletness of the existing NLO analyses of $F_2^{\\gamma}(x,Q^2)$ is pointed out and its origins traced back to the misinterpretation of the behaviour of $q^{\\gamma}(x,M)$ as a function of in the LO photonic coefficient function $C_{\\gamma}^{(0)}(x)$ is given and smooth transition between the properties of virtual and real photon discussed. A simple way of avoiding the problems with the term $\\ln(1-x)$ appearing in the standard expression for $C_{\\gamma}^{(0)}(x)$ in the case of the reaal photon is proposed.

1998-01-01

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481

Experimental study and performance evaluation of convective heat transfer augmentation with coiled wire inserts

Focused-ion beam (FIB) milling provides rapid fabrication of individual cylindrical submicrometer channels with reproducible dimensions (#+-#5% diameters) through 8-#mu#m thick poly(methylmethacrylate) (PMMA) films. PMMA films are spincast on sacrificial Si carriers and sputter-coated with Au before the 30-kV gallium FIB milling process. By adding a trace amount of poly(ethyleneoxide) and poly(dimethylsiloxane) to the PMMA solution before casting, the films can be released for subsequent mounting in microfluidic devices to create hybrid microfluidic-nanofluidic multilevel architectures. In situ FIB sectioning demonstrates the smooth cylindrical surface within the pore. Placing a milled film in contact with an aqueous fluorescein solution fills the channel by capillary action, as verified by confocal fluorescence microscopy. Confocal fluorescence of dyed films reveals that the pores span the thickness of the PMMA film. Small arrays of channels with a defined number ...

2004-08-16

482

Experimental control of a cupola furnace

An experimental study of forced convection heat transfer at the inner tube wall of a double pipe heat exchanger with coiled wire inserts as heat transfer augmentation devices was performed over a turbulent flow region. The test results from twelve augmented tubes with inserts of different combinations of wire diameters (0.813, 1.016 and 1.575 mm) and pitches (2.82, 3.63, 5.08 and 8.47 mm) indicate that the turbulence promoters studied improve heat transfer by a factor of 1.4 to 2.24 compared with a smooth tube, although at a cost of 10-30 times increase in friction factor. A formula for presenting dimensionless exergy losses in a tubular heat exchanger is derived first and then the thermohydrodynamic optimum instead of economic optimum is found by minimizing the exergy losses in the system. From the heat transfer improvement number defined, it is observed that coiled wire turbulence promoters are more effective at Reynolds numbers less than 5.0[times]10[sup 4] in ...

1992-12-01

483

Experimental and analytical studies on turbulent heat transfer performance of a fuel rod with spacer ribs for high temperature gas-cooled reactors

In this paper the authors present some final results from a research project focused on introducing automatic control to the operation of cupola iron furnaces. The main aim of this research is to improve the operational efficiency and performance of the cupola furnace, an important foundry process used to melt iron. Previous papers have described the development of appropriate control system architectures for the cupola. In this paper experimental data is used to calibrate the model, which is taken as a first-order multivariable system with time delay. Then relative gain analysis is used to select loop pairings to be used in a multiloop controller. The resulting controller pairs melt rate with blast volume, iron temperature with oxygen addition, and carbon composition with metal-to-coke ratio. Special (nonlinear) filters are used to compute melt rate from actual scale readings of the amount of iron produced and to smooth the temperature measurement. The temperature ...

1998-08-01

484

Evaluation of the potential of pentachlorophenol degradation in soil by pulsed corona discharge plasma from soil characteristics.

Turbulent heat transfer performance of a fuel rod with three-dimensional trapezoidal spacer ribs for high temperature gas-cooled reactors was studied for various Reynolds numbers using an annular channel at the same coolant condition as the reactor operation, maximum outlet temperature of 1000 C and pressure of 4 MPa, and analytically by a numerical simulation using the k-#epsilon# turbulence model. The turbulent heat transfer coefficients of the fuel rod were 18-80% higher than those of a concentric smooth annulus at a region of Reynolds number exceeding 2000. On the other hand, the predicted average Nusselt number of the fuel rod agreed well with the empirical correlation obtained from the experimental data within a relative error of 10% with Reynolds number of more than 5000. It was verified that the numerical analysis results had sufficient accuracy. Furthermore, the numerical prediction could clarify quantitatively the effects of the heat transfer augmentation ...

485

Drift compression and final focus systems for heavy ion inertial fusion

Chlorinated organics are frequently found as harmful soil contaminants and persisted for extended periods of time. A novel approach, named pulsed corona discharge plasma (PCDP), was employed for the degradation of pentachlorophenol (PCP) in soil. Experimental results showed that 87% of PCP could be smoothly removed in 60 min. Increasing pulse voltage, enhancing soil pH, lowering humic acid (HA) in soil and reducing granular size of the soil were found to be favorable for PCP degradation efficiency. Oxidation and physical processes simultaneously contributed to PCP removal in soil and ozone was the main factor in PCDP treatment. C-Cl bonds in PCP were cleaved during PCDP treatment by Fourier transform infrared spectroscopy (FTIR) analysis. The mineralization of PCP was confirmed by total organic carbon (TOC) and dechlorination analyses. The main intermediate products such as tetrachlorocatechol, tetrachlorohydroquinone, acetic acid, formic acid, and oxalic acid were ...

2010-04-15

486

Don't Panic! Closed String Tachyons in ALE Spacetimes

Longitudinal compression of space-charge dominated beams can be achieved by imposing a head-to-tail velocity tilt on the beam. This tilt has to be carefully tailored, such that it is removed by the longitudinal space-charge repulsion by the time the beam reaches the end of the drift compression section. The transverse focusing lattice should be designed such that all parts of the beam stay approximately matched, while the beam smoothly expands transversely to the larger beam radius needed in the final focus system following drift compression. In this thesis, several drift compression systems were designed within these constraints, based on a given desired pulse shape at the end of drift compression systems were designed within these constraints, based on a given desired pulse shape at the end of drift compression. The occurrence of mismatches due to a rapidly increasing current was analyzed. In addition, the sensitivity of drift compression to errors in the initial ...

2001-05-01

487

Device for controlling water supply to nuclear reactor

We consider closed string tachyons localized at the fixed points of noncompact nonsupersymmetric orbifolds. We argue that tachyon condensation drives these orbifolds to flat space or supersymmetric ALE spaces. The decay proceeds via an expanding shell of dilaton gradients and curvature which interpolates between two regions of distinct angular geometry. The string coupling remains weak throughout. For small tachyon VEVs, evidence comes from quiver theories on D-branes probes, in which deformations by twisted couplings smoothly connect non-supersymmetric orbifolds to supersymmetric orbifolds of reduced order. For large tachyon VEVs, evidence comes from worldsheet RG flow and spacetime gravity. For C{sup 2}/Z{sub n}, we exhibit infinite sequences of transitions producing SUSY ALE spaces via twisted closed string condensation from non-supersymmetric ALE spaces. In a T-dual description this provides a mechanism for creating NS5-branes via closed string tachyon ...

2001-08-20

488

Development, field testing and implementation of automated hydraulically controlled, variable volume loading systems for reciprocating compressors

Object: To smoothly control automatic water supply for realizing stable operation of a nuclear reactor by providing a flow rate limiting signal selection circuit and a preferential circuit in a water supply control device for a nuclear reactor wherein the speed of a recirculation pump may be changed in two-steps. Structure: Opening angle signals for a water supply regulating valve are controlled by a nuclear reactor water level signal, a vapor flow rate signal and a supplied water flow rate signal through an adder and an adjuster in response to a predetermined water level setting signal. When the water in the reactor is maintained at a predetermined level, a selection circuit receives a water pump condition signal for selecting one of the signals from a supplied water rate limiting signal generator generating signals for indicating whether one or two water supply pumps are operated. A low value preferential circuit passes the lower of the values generated from the ...

489

Design improvements and operational experience of programmable digital comparator system

Automated, variable volume unloaders provide the ability to smoothly load/unload reciprocating compressors to maintain ideal operations in ever-changing environments. Potential advantages provided by this load control system include: maximizing unit capacity, optimizing power economy, maintaining low exhaust emissions, and maintaining process suction and discharge pressures. Obstacles foreseen include: reliability, stability, serviceability and automation integration. Results desired include: increased productivity for the compressor and its operators, increased up time, and more stable process control. This presentation covers: system design features with descriptions of how different types of the devices were developed, initial test data, and how they can be effectively operated; three actual-case studies detailing the reasons why automated, hydraulically controlled, variable volume, head-end unloaders were chosen over other types of unloading devices; ...

2003-07-01

490

Comparison of plasma chemistries for inductively coupled plasma etching of InGaAlP alloys

Application of Programmable Digital Comparator System (PDCS) in NPP is to monitor large number of plant parameters and generate contact outputs for reactor trip, reactor setback, process interlocks etc. when parameters cross their operational bounds. Till NAPS these functions are achieved through individual Indicating Alarm Meters (IAM). PDCS used for the first time in KAPS replaces these IAMs. Since its inception, PDCS has undergone improvements in design, incorporates additional functionalities/enhanced features. Dedicated PDCS is provided in TAPP-3 and 4 for protection function. System re-configurability, on-line inter channel comparison of safety critical process parameters' values, Graphic User Interface etc. are other enhancements. From KAPS to TAPP-4 system has given many years of almost trouble-free operation. Commissioning of TAPP-3 system has been very smooth. Objective of the paper is to describe the advantage of the new system, its operating experience, ...

2006-11-13

491

Comparison Of Reionization Models: Radiative Transfer Simulations And Approximate, Semi-Numeric Models

Two plasma chemistries, i.e., CH_4/H_2/Ar and Cl_2/Ar, were compared for the etching of InGaP, AlInP, and AlGaP under inductively coupled plasma (ICP) conditions. While the etching with CH_4/H_2/Ar discharges appears to be ion driven, Cl_2/Ar discharges showed an additional strong chemical enhancement. The highest etch rate (#approx#1 #mu#m/min) for InGaP was achieved at high ICP source power (#>=#750 W) with the Cl_2/Ar chemistry. Cl_2/Ar discharges provided very smooth surfaces in all three materials with root-mean-square roughness measured by atomic force microscopy around 2 nm. This result may be due to the efficient ion-assisted product desorption in this chemistry. The etched near-surface region of InGaP (#approx#100 Angstrom) with Cl_2/Ar maintained almost the same stoichiometry as that of the unetched control. By contrast, the CH_4/H_2/Ar plasma chemistry produced somewhat rougher surfaces and depletion of phosphorous (P) from the surface of InGaP. ...

1998-05-01

492

Combined Scanning Electron Microscope and Micro-InfraRed measurements on Interplanetary Dust Particles

We compare the predictions of four different algorithms for the distribution of ionized gas during the Epoch of Reionization. These algorithms are all used to run a 100 Mpc/h simulation of reionization with the same initial conditions. Two of the algorithms are state-of-the-art ray-tracing radiative transfer codes that use disparate methods to calculate the ionization history. The other two algorithms are fast but more approximate schemes based on iterative application of a smoothing filter to the underlying source and density fields. We compare these algorithms' resulting ionization and 21 cm fields using several different statistical measures. The two radiative transfer schemes are in excellent agreement with each other (with the cross-correlation coefficient of the ionization fields >0.8 for k 0.6 for k < 1 h/Mpc). When used to predict the 21cm power spectrum at different times during reionization, all ionization algorithms agree with one another at the ...

2010-01-01

493

Air conditioner for radioactive material handling facility

Laboratory characterization of Interplanetary Dust Particles (IDPs) collected in the lower stratosphere represents a concrete analysis of cosmic dust properties which played a fundamental role in the origin and evolution of Solar System. The IDPs were characterized by Field Emission Scanning Electron Microscope (FESEM) analyses and by InfraRed (IR) micro-spectroscopy. We present the FESEM images of six IDPs: three smooth grains, two porous and one a compact sphere. We also show the results of micro-IR transmission measurements on four IDPs that allowed us to identify their spectral class according to the criteria defined by Sandford and Walker. Only three of the analyzed particles show IR transmission spectra with a dominant "silicate absorption feature" so that they could be assigned to the three IR spectral classes: one has been classified as "amorphous olivine", one appears to be a mixture of "olivines" and "pyroxenes" and one belongs to the "layer-lattice ...

2007-01-01

494

Accurate, stable, explicit, parabolized navier-stokes solver for high speed flows

An air conditioner intakes open-air from an open-air intake port to remove sands and sea salt particles by air filters. Then, natural and artificial radioactive particles of less than 1 {mu}m are removed by high performance particulate filters. After controlling the temperature by an air heater or an air cooler, air is sent to each of chambers in a facility under pressure elevation by a blower. In this case, glass fibers are used as the filter material for the high performance particulate filter, which has a performance of more than 99.97% for the particles of 0.3 {mu}m grain size. Since this can sufficiently remove the natural radioactive materials intruded from the outside, a detection limit value in each of the chambers of the facility can be set 10{sup -13} to 10{sup -14} {mu}ci/cm{sup 3} in respect of radiation control. Accordingly, radiation control can be conducted smoothly and appropriately. (I.N.).

1991-04-26

495

Absolute spacetime the twentieth century ether

A stable, accurate, and efficient implementation of MacCormack's explicit algorithm for the Parabolized Navier-Stokes equations is demonstrated. The familiar problem of decoding the conservative axial flux vector is solved, resulting in accurate, smooth dependent variable profiles through the viscous-layer sonic line. Source terms due to transformation of the parabolized governing equations into the computational plane and the equations into the computational plane and the resulting metric differencing have been identified and eliminated through inclusion of appropriate geometric conservation law terms. Test cases computed include two- and three-dimensional supersonic and hypersonic flow at laminar and turbulent Reynolds numbers. The computed results demonstrate very good agreement with experiment and with solutions of the full Navier-Stokes equations. Computational times required for the MacCormack explicit PNS code are approximately equal to those of the ...

1986-01-01

496

A new measurement of the antiproton-to-proton flux ratio up to 100 GeV in the cosmic radiation

All gauge theories need ``something fixed'' even as ``something changes.'' Underlying the implementation of these ideas all major physical theories make indispensable use of an elaborately designed spacetime model as the ``something fixed,'' i.e., absolute. This model must provide at least the following sequence of structures: point set, topological space, smooth manifold, geometric manifold, base for various bundles. The ``fine structure'' of spacetime inherent in this sequence is of course empirically unobservable directly, certainly when quantum mechanics is taken into account. This issue is at the basis of the difficulties in quantizing general relativity and has been approached in many different ways. Here we review an approach taking into account the non-Boolean properties of quantum logic when forming a spacetime model. Finally, we recall how the fundamental gauge of diffeomorphisms (the issue of general covariance vs coordinate conditions) raised deep ...

1999-01-01

497

A Topology-Changing Phase Transition and the Dynamics of Flavour

A new measurement of the cosmic ray antiproton-to-proton flux ratio between 1 and 100 GeV is presented. The results were obtained with the PAMELA experiment, which was launched into low-earth orbit on-board the Resurs-DK1 satellite on June 15th 2006. PAMELA is equipped with a silicon-microstrip magnetic spectrometer and a silicon-tungsten imaging calorimeter and has been collecting data since July 2006. During 500 days of data collection a total of about 1000 antiprotons have been identified, including 100 above an energy of 20 GeV. The high-energy results are a ten-fold improvement in statistics with respect to all previously published data. The antiproton-to-proton flux ratio increases smoothly with energy up to about 10 GeV, in agreement with previous experiments, and then levels off. The data follow the trend expected from secondary production calculations and significantly constrain contributions from exotic sources, e.g. dark matter particle annihilations.

2008-01-01

498