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Sample records for quiste epidermoide testicular

  1. Esplenectomía por quiste esplénico epidermoide

    Directory of Open Access Journals (Sweden)

    Samuel Rodrigo Gómez Arenas

    2012-01-01

    Full Text Available Los quistes esplénicos son un padecimiento raro. Se manifiestan de forma poco común en la práctica quirúrgica. Se comunica el caso de una paciente con un quiste esplénico diagnosticado en el Departamento de Cirugía General del Hospital General de Zona núm. 4 del IMSS. La mujer, de 21 años de edad, refirió un cuadro clínico con dolor en el hipocondrio izquierdo, que era causado por un tumor de 7 cm de diámetro, aproximadamente. En la TC, se observó que dicho tumor era un quiste esplénico. Se intentó realizar esplenectomía laparoscópica; sin embargo, debido a las adherencias firmes a la pared abdominal y al colon, el procedimiento se llevó a cielo abierto y se hizo esplenectomía total. El estudio histopatológico corroboró el diagnóstico de quiste esplénico epidermoide.

  2. Bilateral Testicular Epidermoid Cysts

    OpenAIRE

    Norman Loberant; Shweta Bhatt; Edward Messing; Dogra, Vikram S.

    2011-01-01

    Testicular epidermoid cysts are the most common benign tumors of the testes, but account for only 1-2% of all testicular tumors. In a young man presenting with a testicular mass, a high index of suspicion must be maintained for the malignant testicular germ cell tumor, which is 50-times more common than testicular epidermoid cyst. Bilateral testicular epidermoid cysts are a very rare condition, with only a few reports in the literature. It is extremely important in this condition to make a co...

  3. Testicular epidermoid cyst

    Directory of Open Access Journals (Sweden)

    Basri Çakiroglu

    2015-01-01

    Full Text Available Epidermoid cyst of the testis is a benign, non-teratomatous tumour. It is often possible to make the diagnosis pre-operatively, combining typical sonographic features with normal biochemical tumour markers. The accurate pre-operative diagnosis will allow for testis-sparing surgery and prevent unnecessary orchiectomy. An 11-year-old boy with testicular epidermoid cyst who presented with pain in testis was presented in this report.

  4. Concomitant bilateral testicular epidermoid cysts

    International Nuclear Information System (INIS)

    Epidermoid cyst of the testis is a rare benign germ tumor, comprising 1-2% of all resected benign testicular masses. Approximately 300 cases have been reported to date. Unilateral involvement has often been reported in the English literature. However, bilateral occurrence is very rare and to the best of our knowledge, there only 3 previous reports of bilateral testicular epidermoid cysts. The fact that they are completely benign makes them amenable to treatment by local excision, thereby saving patient from orchidectomy. Recognition of their characteristic ulatrsonographic features is very important to avoid unnecessary intervention. We present here, a case of bilateral epidermoid cyst in which characteristic ultrasound (US) findings allowed testis-sparing enucleation instead of radical orchiectomy. (author)

  5. Quiste epidermoide en la región preauricular: Reporte de un caso / Epidermoid cyst into preauricular region: A case report

    Scientific Electronic Library Online (English)

    Oscar, Venegas R; Benjamín, Martínez R; Bárbara, Olivos B; Carolina, Vallejos & #924; ; Mauricio, Zambra R.

    2011-08-01

    Full Text Available Los quistes dermoides son malformaciones que ocurren en el área de cabeza y cuello con una frecuencia de 1,6% a 6,9%. Histológicamente podemos clasificarlos en epidermoide, dermoide o teratoide. Presentamos un caso de un paciente de sexo masculino, quien se presentó en nuestro hospital con un quiste [...] preauricular, que fue enucleado y confirmado histopatológicamente como quiste epidermoide. Abstract in english Dermoid cysts are malformations occurring in the head and neck region with an incidence ranging from 1.6% to 6.9%. Histologically, they can be further classified as epidermoid, dermoid or teratoid. We report a case of adult male who presented at our hospital with a preauricular cyst; it was excised [...] and confirmed histopathologically as an epidermoid cyst.

  6. Quiste epidermoide en la región preauricular: Reporte de un caso Epidermoid cyst into preauricular region: A case report

    Directory of Open Access Journals (Sweden)

    Oscar Venegas R

    2011-08-01

    Full Text Available Los quistes dermoides son malformaciones que ocurren en el área de cabeza y cuello con una frecuencia de 1,6% a 6,9%. Histológicamente podemos clasificarlos en epidermoide, dermoide o teratoide. Presentamos un caso de un paciente de sexo masculino, quien se presentó en nuestro hospital con un quiste preauricular, que fue enucleado y confirmado histopatológicamente como quiste epidermoide.Dermoid cysts are malformations occurring in the head and neck region with an incidence ranging from 1.6% to 6.9%. Histologically, they can be further classified as epidermoid, dermoid or teratoid. We report a case of adult male who presented at our hospital with a preauricular cyst; it was excised and confirmed histopathologically as an epidermoid cyst.

  7. Teratoma quístico maduro testicular (quiste dermoide): Aportación de un caso y revisión de la literatura / Mature cystic teratoma of the testis (dermoid cyst): Case report and literature review

    Scientific Electronic Library Online (English)

    P., Garrido Abad; L.M., Herranz Fernández; M., Jiménez Gálvez; C., Suárez Fonseca; D., Santos Arrontes; S., Nieto Llanos; M., Fernández Arjona.

    2009-11-01

    Full Text Available Objetivos: Aportamos un caso de un teratoma quístico maduro testicular (quiste dermoide) en su variante pseudopilomatrixoma. Métodos: Paciente de 53 años con una masa testicular izquierda no dolorosa al que, tras la realización de orquiectomía radical, se diagnostica de teratoma quístico maduro test [...] icular (quiste dermoide) en su variante pseudopilomatrixoma. Estudio de extensión y marcadores tumorales negativos. El paciente se encuentra libre de enfermedad tras 6 meses de seguimiento. Resultados: El teratoma testicular es un tumor compuesto por células derivadas de las tres hojas embrionarias (ectodermo, endodermo y mesodermo). Aparecen a cualquier edad, siendo mucho más incidentes en la infancia, donde llegan a representar hasta un 30% de todos los tumores. En la edad adulta es mucho menos prevalente, llegando sólo a representar un 7% de todos los tumores germinales del testículo. Conclusiones: Los casos prepuberales son casi invariablemente de carácter benigno, independientemente de su histología. Sin embargo, los casos que aparecen tras la pubertad presentan potencial maligno, incluso si es histológicamente puro. El teratoma quístico maduro (quiste dermoide) representa la única excepción a esta regla, ya que no se ha publicado ninguna degeneración maligna de este tipo de tumores. Abstract in english Objectives: Case report of a mature cystic teratoma (dermoid cyst), pseudopilomatrixoma like variant. Method: 53-year old patient with a left testicular mass, diagnosed as mature cystic teratoma of the testis (dermoid cyst), the pilomatrixoma-like variant, after radical orchiectomy. Tumoral markers [...] were negative and no extension was observed. The patient is disease-free after 6 months follow-up. Results: Testicular teratoma is a tumour composed of cells derived from the three embryonic layers (ectoderm, endoderm and mesoderm). They can appear at any age, but they are much more prevalent in childhood. They appear at any age, but are much more common in childhood, where they comprise up to 30% of all tumours. They are much less prevalent in adults, representing only 7% of all testicular germ cell tumours Conclusions: Prepubertal cases are invariably benign in nature, regardless of their histology. However, cases which appear after puberty are potentially malignant, even if histologically pure. Mature cystic teratoma (dermoid cyst) is the only exception to this rule, as no malignant degeneration of these types of tumours has been published.

  8. QUISTES VAGINALES

    Directory of Open Access Journals (Sweden)

    Arlette Adauy E

    2006-01-01

    Full Text Available Se reportan dos casos de quistes vaginales: se analiza el cuadro clínico y su dificultad diagnósticaWe report two cases of vaginal cysts: clinical presentation and diagnostic difficulties are analysed

  9. Epidermoid cyst of the testis: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Docal, I.; Crespo, C.; Pardo, A.; Prieto, A.; Alonso, P. [Servicio de Radiologia, Hospital Da Costa, Burela (Lugo) (Spain); Calzada, J. [Servicio de Anatomia Patologica, Hospital Da Costa, Burela (Lugo) (Spain)

    2001-05-01

    Epidermoid cyst of the testis is an uncommon benign tumour, with an overall incidence of 1-2 % of all resected testicular masses. When imaging findings suggest that an intratesticular mass is likely to be an epidermoid cyst, conservative management (enucleation with testicular preservation) can be performed rather than orchidectomy. This case report records an epidermoid cyst in a 12-year-old boy in whom the US findings allowed testis-sparing surgery instead of orchidectomy. (orig.)

  10. Benign Intratesticular Epidermoid Cyst of the Testis: Diagnostic Dilemma

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    Kishor H Suryawanshi

    2014-05-01

    Full Text Available Intratesticular epidermoid cysts of the testis are rare benign lesions, comprising about 1-2% of all the testicular neoplasms. Clinically it may not be differentiated reliably from the most common malignant testicular tumours and poses a diagnostic dilemma. Majority of the testicular tumours are malignant one, hence accurate diagnosis in benign lesions such as epidermoid cyst is always warranted to avoid unnecessary invasive procedures like orchidectomy. Herein, we present a case of benign, intratesticular epidermoid cyst of the testis in a 30 years old male treated by conservative approach with testicular preservation, avoiding unnecessary orchidectomy.

  11. Benign Intratesticular Epidermoid Cyst of the Testis: Diagnostic Dilemma

    OpenAIRE

    Suryawanshi, Kishor H; Dhiraj B. Nikumbh; Parvez Mujawar; Poonam Pagare; Shivraj N Kanthikar

    2014-01-01

    Intratesticular epidermoid cysts of the testis are rare benign lesions, comprising about 1-2% of all the testicular neoplasms. Clinically it may not be differentiated reliably from the most common malignant testicular tumours and poses a diagnostic dilemma. Majority of the testicular tumours are malignant one, hence accurate diagnosis in benign lesions such as epidermoid cyst is always warranted to avoid unnecessary invasive procedures like orchidectomy. Herein, we present a case of benign, i...

  12. Quistes pulmonares congénitos

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    Nuvia Suárez García

    2014-06-01

    Full Text Available Introducción: las malformaciones pulmonares congénitas constituyen una alteración en el desarrollo embriológico y fetal de las distintas estructuras pulmonares y una rara expresión de estas son los quistes pulmonares congénitos. Caso clínico: se presenta un recién nacido a término, de buen peso, asintomático y estable hasta el tercer día de vida al debutar con un estado de shock séptico secundario, de bronconeumonía complicada con derrame pleural derecho. En los estudios evolutivos hacia el cuarto de día de vida se le diagnostica como hallazgo radiológico la presencia de quistes pulmonares que evolucionan de forma asintomática. Después de una valoración multidisciplinaria es egresado con un seguimiento por su condición de alto riesgo. Actualmente saludable y con buen desarrollo psicomotor. Conclusiones: la importancia del tema que se presenta es que se describe una presentación rara de quistes pulmonares congénitos en un recién nacido que desarrolló un estadio avanzado de sepsis.

  13. Quiste gigante de ovario

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    Dagoberto Calderón Rodríguez

    2014-08-01

    Full Text Available Un crecimiento quístico del ovario debe medir por lo menos 2,5 cm de diámetro para denominarse quiste. Se presenta el caso de una paciente de 36 años, femenina, perteneciente a la etnia Wayú, con un quiste gigante en ovario derecho, de aproximadamente 10 cm de diámetro, un peso de 3,6 Kg y torcido sobre su pedículo, que le provoca dolor intenso de más de un mes de evolución. Se practicó intervención quirúrgica y se comprobaron signos macroscópicos de necrobiosis de ovario, siendo el resultado de la biopsia un teratoma maduro. Su resultado final fue satisfactorio

  14. Quiste dermoide corneal bilateral

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    Michel Guerra Almaguer

    2015-06-01

    Full Text Available El dermoide es un tipo de coristoma (tejido embrionario normal en una localización anormal que afecta con frecuencia la córnea. Aparece como una masa sólida, blanca, redonda y elevada. Suele localizarse en el limbo inferotemporal, aunque puede hacerlo en cualquier lugar del globo ocular o de la órbita. Se presenta un paciente masculino, de 8 años de edad, quien desde su nacimiento muestra una mancha blanca en ambos ojos, agudeza visual sin corrección de movimiento de mano a 33 centímetros en el ojo derecho y percepción luminosa en el ojo izquierdo. En la exploración oftalmológica de ambos ojos se apreciaron lesiones blanquecinas sobre la córnea. Se le realizó exéresis del quiste y queratoplastia lamelar de ambos ojos, con resultados visuales satisfactorios. Se concluye que el caso presenta un quiste dermoide corneal bilateral.

  15. Quiste dermoide cervical

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    Yurian Gbenou Morgan

    2015-09-01

    Full Text Available Los quistes dermoides presentan una incidencia de 1,6 hasta 6,9 % en la región de cabeza y cuello. Se realiza el siguiente reporte de caso clínico con el objetivo de enfatizar en la importancia de un adecuado manejo diagnóstico preoperatorio, para establecer una acertada planificación quirúrgica en la exéresis de este tipo de lesiones de la región cervicofacial. Se presenta el caso clínico de un paciente masculino, de 13 años de edad, quien hacía 3 años se notaba un crecimiento redondeado en región submentoniana, lo cual le ocasionaba molestias al hablar y ligera afectación de su estética facial. Una vez realizados los estudios complementarios preoperatorios, se decide tratamiento quirúrgico, empleando una cervicotomía medial para la extirpación de la lesión quística, dada la ubicación anatómica por debajo del músculo milohiodeo y su gran dimensión. El diagnóstico histopatológico se corresponde con un quiste epidérmico. Se concluye que resulta imprescindible realizar un exhaustivo examen físico e imagenológico, para lograr resultados satisfactorios en el tratamiento quirúrgico del quiste dermoide cervical.

  16. Epidermoid cyst post dermofasciectomy.

    LENUS (Irish Health Repository)

    Henry, Francis P

    2010-01-01

    We report the finding of an unusual presentation of an epidermoid cyst 3 years following dermofasciectomy for Dupuytren\\'s disease. Epidermoid cysts remain a rare entity in the palmoplanter distribution but also a very unusual finding within the confines of a full thickness skin graft.

  17. MASA NASAL CONGÉNITA: QUISTE EPIDERMOIDE Congenital nasal mass: epidermoid and dermoid cyst

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    Gilberto Eduardo Marrugo-Pardo

    2010-12-01

    Full Text Available Las masas nasales congénitas de la línea media son poco frecuentes, pero ante la sospecha clínica debe realizarse una valoración completa que incluya imágenes diagnósticas para descartar origen intracraneal. Se presenta un caso clínico con la presencia de dos entidades clínicas de diferentes características histológicas junto con una revisión de la literaturaCongenital midline nasal mass are infrequent but before the clinical suspicion should be carried out a complete evaluation that includes diagnostic images with the aim of ruled out intracraneal lesion. This paper presented a clinical case is with two clinical entities of different histological characteristic together with a revision of the literature.

  18. Quistes de los maxilares

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    Ivan Alberto Manotas Arevalo

    2013-12-01

    Full Text Available Los Grandes Quistes de los Maxilares han estado vinculados siempre a la humanidad, desde tiempos remotos, pues han sido halladas en restos de especimenes fosiles, han llamado la atencion de los clínicos, en torno a su etiologia, en la que se ha introducido la participacion de la genetica, (demostrada en el desarrollo de los queratoquistes maxilares, la fisiopatologia, caracteristicas histologicas (inmunohistoquimica, posibilidades diagnosticas por la imagen, (como la tomografia computarizada y la resonancia nuclear magnetica y otras pruebas. Además llaman la atención al estudio, por sus alternativas de manejo especialmente las formas radicales, y el analisis de asociaciones a otras patolo-gias benignas y malignas, y de la recurrencia muy alto de algunas de estas lesiones. Mucho se ha desarrollado para elucidar su naturaleza real, estadificar adecuadamente la lesion descartando asocia-ciones patologicas sindromicas, indicar un tratamiento apropiado, y realizar seguimientos a largo plazo. Este articulo pretende recaudar una information general que de parametros para abordar el estudio de los quistes maxilares a partir de la presentacion de un caso clinico.

  19. Testicular Injuries

    Science.gov (United States)

    ... Can I Help a Friend Who Cuts? Testicular Injuries KidsHealth > For Teens > Testicular Injuries Print A A ... addressed as soon as possible. continue Serious Testicular Injuries Examples of serious testicular injury are testicular torsion ...

  20. Intracranial epidermoid carcinoma: CT and MRI

    Energy Technology Data Exchange (ETDEWEB)

    Uchino, A. [Kyushu Univ. Hospital, Fukuoka (Japan). Dept. of Radiology; Hasuo, K. [Kyushu Univ. Hospital, Fukuoka (Japan). Dept. of Radiology; Matsumoto, S. [Kyushu Univ. Hospital, Fukuoka (Japan). Dept. of Radiology; Uda, K. [Kyushu Univ. Hospital, Fukuoka (Japan). Dept. of Neurosurgery; Moriguchi, M. [Kyushu Univ. Hospital, Fukuoka (Japan). Dept. of Neurosurgery; Nishio, T. [Kyushu Univ. Hospital, Fukuoka (Japan). Dept. of Neurosurgery; Fukui, M. [Kyushu Univ. Hospital, Fukuoka (Japan). Dept. of Neurosurgery; Masuda, K. [Kyushu Univ. Hospital, Fukuoka (Japan). Dept. of Radiology

    1995-02-01

    We report a patient with an epidermoid carcinoma an extremely rare brain tumour, in the right cerebellopontine angle cistern. Contrast enhancement is the most important feature for differential diagnosis of epidermoid carcinomas from atypical benign epidermoid cysts. (orig.)

  1. Ultrasonographic findings of testicular tumors: Correlation with pathologic findings

    International Nuclear Information System (INIS)

    Scrotal sonography is a valuable tool for assessing the testis and surrounding structures, and has become the imaging modality of choice for evaluation of the scrotum. Scrotal sonography is also helpful for differentiating cystic from slid mass and testicular from extratesticular mass, but is sometimes difficult in differentiating malignant tumor from various benign conditions such as epidermoid cyst, focal orchitis, testicular hematoma, and abscess. We demonstrate the sonographic findings of the various testicular mass, and correlation with pathologic findings.

  2. Terry Quist Discusses Skylab Experiment

    Science.gov (United States)

    1972-01-01

    San Antonio, Texas high school student, Terry C. Quist (left), and Dr. Raymond Gause of the Marshall Space Flight Center (MSFC), discuss the student's experiment to be performed aboard the Skylab the following year. His experiment, 'Earth Orbital Neutron Analysis' required detectors such as the one he is examining in this photo. The detector was to be attached to a water tank in Skylab. Neutrons striking the detectors left traces that were brought out by a chemical etching process after the Skylab mission. Quist's experiment seeked to record neutron hits, count them, and determine their direction. This information was to help determine the source of neutrons in the solar system. Quist was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC two months earlier where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment. The equipment for the experiments was manufactured at MSFC.

  3. Neuroradiological aspects of intracranial epidermoids

    International Nuclear Information System (INIS)

    Intracranial epidermoids are primarily extracerebral congenital cysts. Intra- and extradural types are differentiated: intradural lesions originate in the intracranial CSF spaces, and extradural lesions in the bony skull. Epidermoids increase in size passively as the results of an increase in the cyst volume and not because of active growth. Clinically epidermoids behave like benign, slow-growing cerebral tumours. Differential diagnosis includes other cysts and cystic tumours. Neuroradiologically epidermoids present as polycystic lesions showing extensive growth in the extracerebral CSF spaces and secondary invagination of the brain. On CT and MR, despite the high cholesterol content, epidermoids show the characteristics of liquor and not those of fat. It can be shown that he typical CT and MR appearance of an epidermoid is due to the different proportions of CSF in the cyst content, which results from diffusion of dehiscence of te cyst capsule. The present study was based on analysis of 6 cases selected from a total of 29 patients with CNS epidermoids. (orig.)

  4. Quiste dermoide del suelo de la boca

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    Ayelén María Portelles Massó

    2010-12-01

    Full Text Available El quiste dermoide representa menos del 0,01 % de todos los quistes de la cavidad bucal. Su ubicación más frecuente es en suelo de boca. Se presenta el caso de una paciente femenina de 19 años de edad que hacía aproximadamente 7 años había notado un aumento de volumen debajo de la lengua, el cual le crecía paulatinamente y ya se apreciaba por fuera de la cara. Además, le ocasionaba molestias al hablar y al masticar. Se realizaron estudios complementarios y bajo anestesia general nasotraqueal. Se procedió a su exéresis quirúrgica mediante un abordaje intrabucal, donde se obtuvieron excelentes resultados estéticos y funcionales. El diagnóstico histopatológico se correspondió con un quiste dermoide de suelo de boca. La paciente no ha tenido recurrencia de la lesión transcurridos tres años de la operación. El quiste dermoide de suelo de boca se presenta como una tumoración benigna de la línea media. La exéresis intrabucal demuestra beneficios estéticos y funcionales.

  5. Quiste suprarrenal primario Primary adrenal cyst

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    Patricio Cabané T

    2011-12-01

    Full Text Available Los quistes suprarrenales son las lesiones quísticas más frecuentes de la glándula suprarrenal, a pesar de que constituyen una rara entidad. Típicamente se presentan por un cuadro de dolor abdominal o masa palpable, pero en la actualidad se detectan cada vez con más frecuencia en estudios radiológicos como incidentalomas. Los quistes suprarrenales cuentan con amplios diagnósticos diferenciales, lo que hace un difícil diagnóstico definitivo y una dificultad en el manejo posterior. Estos quistes se clasifican en cuatro subtipos: endoteliales, pseudoquiste, epiteliales y parasitarios. El manejo de un quiste suprarrenal se puede resumir en tres pilares fundamentales: descartar el estado funcional del quiste, evaluación de eventual malignidad por imágenes, y evitar las posibles complicaciones (hemorragia, infección, sobre todo en los quistes de gran tamaño. Se presenta el caso de una paciente con quiste suprarrenal izquierdo no funcionante asociado a dolor abdominal. Se realiza revisión de la literatura y se plantean los distintos diagnósticos y alternativas terapéuticas.Adrenal cyst is the commonest type of benign lesions of adrenal gland, althought is a very rare entity. Tipically, they are presented with abdominal pain or palpable mass, but nowdays they are detected most frecuently an imaging studies like incidentaloma. Adrenal Cyst have a broad differential diagnoses, rendering definitive diagnosis and subsequent management difficult. Are categorized into four subtypes: endothelial, pseudocyst, epithelial, and parasitic. This management paradigm may be summarized as: ruling out functional status of the cyst, evaluating chances of incidental malignancy by imaging, avoiding potential complications of surveillance (hemorrhage, infection, particularly in large cysts. A case of a patient with a left non-functioning adrenal cyst is reported, with abdominal pain. The diagnostic and therapeutic options are discussed and the literature is reviewed.

  6. Quiste odontógeno: Presentación de caso

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    Gladys Pérez López

    2003-12-01

    Full Text Available Se presenta un paciente de 18 años de edad, remitido al Servicio de Otorrinolaringología del Hospital Clinicoquirúrgico "Comandante Manuel Fajardo", con el cuadro clínico de sinusitis recurrente y opacidad homogénea de seno maxilar izquierdo . La radiografia convencional de senos perinasales es considerada un medio diagnóstico muy importante al nivel de la atención primaria de salud, aunque también se considera necesario el ortopantograma para el diagnóstico diferencial (dientes supernumerarios, quistes dentígenos, molares retenidos. La técnica de Caldwell-Luc mejora la visibilidad y accesibilidad de las lesions, contribuye al diagnóstico, al alivio del paciente y está exenta de complicaciones.A case of 18-years old male patient with recurrent maxillary sinusitis and radiographic study with opacity in left maxillay sinus was reported. He was admitted at the Otorhinolaringology Department of "Comandante Manuel Fajardo" university clinical and surgical hospital. Conventional radiographic examination of perinasal sinus is considered a very important tool in primary health care; but also orthopantogram is required to exclude diverse diagnosis (supernumerary teeth, dentigenous cyst, and embedded tooth. The Caldwell-Luc approach improves visibility of and accesibility to lesions, contributes to make diagnosis and relieves the patient's condition without further complications. The most relevant quotations found in research works about the topic were selected.

  7. Quiste dermoide verdadero en piso de boca

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    Daniel Antunes Freitas

    2013-09-01

    Full Text Available Los quistes dermoides son lesiones benignas de origen embrionario, con una incidencia del 0,01 % de todos los quistes de la cavidad bucal. No presenta predicción por sexo y alrededor del 60 % de los casos se desarrollan entre los 15 y 35 años de edad. El conocimiento de los hallazgos clínicos de este tipo lesiones es vital para un diagnóstico definitivo, sin embargo, este siempre debe ser corroborado mediante exámenes histopatológicos, especialmente, al realizar un diagnóstico diferencial entre los diferentes tipos de quiste dermoides u otras alteraciones a nivel oral con manifestaciones clínicas similares. El propósito de esta presentación reportar un caso clínico para ampliar conocimientos sobre el diagnóstico y tratamiento de este tipo de lesión debido a su infrecuencia en cavidad oral. La ubicación inusual de estos quistes en cavidad oral hace que, aún con una buena valoración clínica e imaginológica, el diagnóstico prequirúrgico preciso sea difícil. Es por esto que el tratamiento quirúrgico no sólo evita el riesgo de una complicación infecciosa y eventual malignización sino que permite obtener un diagnóstico definitivo mediante estudios histopatológicos.

  8. Recidiva tardía de carcinoma epidermoide de pene / Epidermoid pennis carcinoma recidive

    Scientific Electronic Library Online (English)

    E., Sanz Mayayo; R., Rodríguez-Patrón Rodríguez; I., Gómez García; D., García Ortells; R., García Navas; R., García González; Á., Escudero Barrilero.

    2003-12-01

    Full Text Available OBJETIVO: Presentar un caso de recidiva de carcinoma epidermoide de pene a los 21 años de la cirugía. MÉTODO: Se trata de un paciente de 85 años con antecedentes de penectomía parcial por carcinoma epidermoide, que presenta lesión excrecente a nivel de glande de 1 mes de evolución. Se biopsia siendo [...] el resultado carcinoma epidermoide por lo que se realiza penectomía total con uretrostomía cutánea. RESULTADO: El estudio histopatológico de la pieza confirmó un carcinoma epidermoide bien diferenciado. Abstract in english OBJETIVE: We report a recidive of pennis carcinoma after 21 years of surgery. METHODS: This is the case of a male of 85 years old, with parcial penectomy; by epidermoid carcinoma. In phisics exploration, that it displays excrecente lesion at level of glande of 1 month of evolution. Biopsy being the [...] result of epidermoid carcinoma reason why is made. Total penectomy, a with cutaneus uretrostomy. RESULTS: The histopathological study of the piece, confirm a epidermoid carcinoma well differentiated.

  9. Neuroradiological aspects of intracranial epidermoids; Zur neuroradiologischen Diagnostik der intrakraniellen Epidermoide

    Energy Technology Data Exchange (ETDEWEB)

    Hagen, T. [Universitaetskliniken des Saarlandes, Homburg/Saar (Germany). Inst. fuer Neuroradiologie; Kujat, C. [Universitaetskliniken des Saarlandes, Homburg/Saar (Germany). Inst. fuer Neuroradiologie; Donauer, E. [Universitaet des Saarlandes, Homburg/Saar (Germany). Neurochirurgische Klinik; Piepgras, U. [Universitaetskliniken des Saarlandes, Homburg/Saar (Germany). Inst. fuer Neuroradiologie

    1994-11-01

    Intracranial epidermoids are primarily extracerebral congenital cysts. Intra- and extradural types are differentiated: intradural lesions originate in the intracranial CSF spaces, and extradural lesions in the bony skull. Epidermoids increase in size passively as the results of an increase in the cyst volume and not because of active growth. Clinically epidermoids behave like benign, slow-growing cerebral tumours. Differential diagnosis includes other cysts and cystic tumours. Neuroradiologically epidermoids present as polycystic lesions showing extensive growth in the extracerebral CSF spaces and secondary invagination of the brain. On CT and MR, despite the high cholesterol content, epidermoids show the characteristics of liquor and not those of fat. It can be shown that he typical CT and MR appearance of an epidermoid is due to the different proportions of CSF in the cyst content, which results from diffusion of dehiscence of te cyst capsule. The present study was based on analysis of 6 cases selected from a total of 29 patients with CNS epidermoids. (orig.) [Deutsch] Intrakranielle Epidermoide sind primaer extrazerebrale kongenitale Zysten. Es sind intra- von extraduralen Formen zu unterscheiden. Intradurale Epidermoide entstehen in den intrakraniellen Liquorraeumen, extradurale im Schaedelknochen. Epidermoide vergroessern sich nicht aktiv durch autonomes Wachstum, sondern passiv durch Zunahme des Zysteninhalts. Klinisch verhalten sie sich wie gutartige, langsam wachsende Hirntumoren. Differential-diagnostisch sind sie gegenueber anderen Zysten und zystischen Tumoren abzugrenzen. Neuroradiologisch sind Epidermoide durch ihre polyzyklische Konfiguration und ihre extensive Ausdehnung in den extrazerebralen Liquorraeumen mit sekundaerer Invagination in das Gehirn gekennzeichnet. Im MR und im CT stellen sich Epidermoidzysten trotz des hohen Gehaltes an Cholesterin nicht fett-, sondern liquoraequivalent dar. Es kann nachgewiesen werden, dass die Ursache fuer die Abbildungseigenschaften der Epidermoide in einer unterschiedlichen transmuralen Beimengung von Liquor cerebrospinalis zum Zysteninhalt liegt. Die Studie basiert auf der Analyse von 6 Faellen, die aus einem Gesamtkollektiv von 29 Patienten mit Epidermoiden des Zentralnervensystems ausgewaehlt wurden. (orig.)

  10. Testicular microlithiasis and testicular cancer

    DEFF Research Database (Denmark)

    Pedersen, Malene Roland; Rafaelsen, Søren Rafael; Møller, Henrik; Vedsted, Peter; Osther, Palle Jörn

    2016-01-01

    Purpose To perform a systematic literature review to assess whether the occurrence of testicular microlithiasis (TML) in conjunction with other risk factors is associated with testicular cancer. Methods A systematic literature search was performed of original articles in English published 1998 to...

  11. Recurrent intramedullary epidermoid cyst of conus medullaris.

    LENUS (Irish Health Repository)

    Fleming, Christina

    2011-01-01

    Spinal intramedullary epidermoid cyst is a rare condition. Recurrent epidermoid cyst in the spine cord is known to occur. The authors describe a case of recurrent conus medullaris epidermoid cyst in a 24-year-old female. She initially presented at 7 years of age with bladder disturbance in the form of diurnal enuresis and recurrent urinary tract infection. MRI lumbar spine revealed a 4 cm conus medullaris epidermoid cyst. Since the initial presentation, the cyst had recurred seven times in the same location and she underwent surgical intervention in the form of exploration and debulking. This benign condition, owing to its anatomical location, has posed a surgical and overall management challenge. This occurrence is better managed in a tertiary-care centre requiring multi-disciplinary treatment approach.

  12. Testicular Exams

    Science.gov (United States)

    ... Diseases & Conditions Infections Q&A School & Jobs Drugs & Alcohol Staying ... español Exploraciones testiculares Medical exams, whether they're for school, a sport, or camp, are usually pretty straightforward. Many parts ...

  13. Testicular self-exam

    Science.gov (United States)

    Screening - testicular cancer - self-exam; Testicular cancer - screening - self-exam ... A testicular self-exam is done to check for testicular cancer . Testicles have blood vessels and other structures that can make the exam ...

  14. Quiste esplénico abscedado: reporte de un caso

    Directory of Open Access Journals (Sweden)

    Roxana Montenegro

    2003-12-01

    Full Text Available Los autores reportan un raro caso de un absceso esplénico crónico, en un paciente varón de 52 años de edad; a quien dos años antes de su ingreso al hospital se le diagnosticó en forma casual -diagnóstico por imágenes- un quiste esplénico con paredes calcificadas, estando previamente asintomático. Al momento de su ingreso se presentó con una historia de 12 meses de dolor leve en cuadrante superior izquierdo del abdomen como única manifestación positiva. Luego de una intervención quirúrgica, el diagnóstico correspondió a un absceso esplénico crónico o seudoquiste esplénico por los hallazgos anatomopatológicos. Se describe las características del caso y se revisa la literatura.

  15. Equinococosis humana (quiste hidatidico): dos casos

    OpenAIRE

    Lichtenberger, Egon

    2011-01-01

    Se describen dos casos de quiste indatídico hepático en pacientes colombianos, oriundos del Chocó y de la Guajira, respectivamente. La equinococosis es posiblemente más frecuente en Colombia de lo que comúnmente se supone. Se hace un corto resumen de la anatomía patológica, morfología, ciclo vital, epidemiología y medios diagnósticos de esta parasitosis.The author describes two cases of hepatic echinococcosis demonstrating again, as correa henao and bojanini have done before, that this parasi...

  16. Quiste de erupcion en denticion mixta

    Directory of Open Access Journals (Sweden)

    Mileydis Esther Fernández Munive

    2013-10-01

    Full Text Available Title: Cyst of eruption in mixed dentition.ResumenLos quistes de erupción se presentan como áreas en la mucosa de levantamiento de volumen blando, de diferente coloración: azulado, rojo, vinaceo; mantiene un vaso presionado del que no solo sale agua, sino también sangre. Determinado como una variante del quiste dentígero, de origen odontogénico epitelial, diferentes porque este existe dentro del hueso; habitualmente en asociación con dientes próximos a erupcionar y en su gran mayoría relacionados con dentición mixta. En este caso clínico expuesto, la relación es con la erupción del diente 44, se muestra el abordaje y el control posoperatorio en el cual demuestra a través de fotografías la erupción adecuada del diente. (DUAZARY 2012 No. 2, 196 - 200AbstractThe cysts of eruption appear as areas in the mucous one of raising of soft volume, of different coloration: bluish, red, vinaceo; it keeps a glass pressed of the one that not only goes out waters down, but also bleed. Determined as a variant of the cyst dentígero, of origin odontogénic epitelial, different because this one exists inside the bone; habitually in association with near teeth to erupcionar and in his great majority related to mixed dentition. In this clinical exposed case, the relation is with the eruption of the tooth 44, the boarding and the control appears posoperatorio in which it demonstrates across photographies the suitable eruption of the tooth.Keywords: Tooth eruption; Odontogenic Cysts; Dentition Mixed. (MeSH.

  17. Unusual Cases of Epidermoid cyst: Case Series

    Directory of Open Access Journals (Sweden)

    Lalita Yadav

    2013-09-01

    Full Text Available In the oro-facial region cystic lesions of different etiologies are encountered owing to the presence of the teeth in the jaw bones. A bewildering variety of developmental, odontogenic and non-odontogenic cysts are seen. Epidermoid cyst is a rare developmental cyst of the oro-facial region which results from entrapped epidermal elements without adnexal appendages. Dermoid and epidermoid cysts occur in oro-facial region with an incidence of 6.9-7% and represents less than 0.01% of all oral cavity cysts. Here we report two cases of epidermoid cysts occurring at unusual locations involving upper left maxillary region lateral to the nose and pinna of the ear.

  18. Suprasellar epidermoid presenting with precocious puberty

    Directory of Open Access Journals (Sweden)

    Nigel Peter Symss

    2007-01-01

    Full Text Available Epidermoids are inclusion tumors of the central nervous system and are rare, benign slow-growing tumors. They are estimated to constitute 0.5-1.8% of the brain tumors and have an affinity for the subarachnoid cisterns at the base of the brain, the suprasellar cistern being one of the most favoured sites. We report a case of suprasellar epidermoid in a 2-year-old male child with an unusual CT and MRI appearance, who presented to us in February 1995 with features of precocious puberty. In October 2004, at the age of 11 years, he presented with symptoms and signs of raised ICP.

  19. Quiste residual gigante: presentación de un caso

    Directory of Open Access Journals (Sweden)

    Oscar Rivero Pérez

    2014-01-01

    Full Text Available Fundamento: u n quiste es una estructu ra con tendencia a la forma redondeada, constituida por una pared externa de tejido conectivo fibroso, una pared interna formada por un tapiz epitelial. La cavidad quística contiene un material líquido o semilíquido de color cetrino que, cuando se infecta, se convierte en purulento y carmelitoso. El quiste residual puede haber sido anteriormente un quiste lateral o un quiste apical y al haberse extraído el diente, a par tir de cuyo periodonto se forma el quiste , se queda en el tejido óseo sin haber sido exti rpado. Objetivo: presentar un caso al cual se le diagnosticó y trató un quiste residual mandibular que abarcaba la hemiarcada izquierda, que permitió restablecer las funciones masticatorias y estética. Caso Clínico: paciente que fue atendido en la consult a de Cirugía Maxilofacial de la Facultad de Estomatología de Camagüey , con un aumento de volumen en la región lateral izquierda, con antecedentes de trauma anterior que le provocó fractura de mandíbula. Se describen las características clínicas de la enfer medad y el tratamiento quirúrgico realizado, se utilizó para el mismo los principios de la técnica de enucleación . 577 Conclusiones: a unque se han reportados pocos c asos en la l iteratura nacional y extranjera, estos han sido quiste s de menor tamaño que inclu yen uno o dos dientes, no existen reportes de quistes residuales que involucren toda la arcada o hemiarcada dentaria. Se obtuvieron resultados estéticos satisfactorios con la técnica quirúrgica empleada y no se presentaron complicaciones.

  20. Testicular lymphoma

    DEFF Research Database (Denmark)

    Møller, Michael Boe; d'Amore, F; Christensen, Bjarne Egelund

    In a Danish population-based non-Hodgkin's lymphoma registry, 2687 newly diagnosed patients were registered from 1983 to 1992. 39 had testicular involvement (TL) (incidence 0.26/10(5)/year). Median age was 71 years. 24 cases had localised and 15 had disseminated disease. Histologically, all cases...

  1. Testicular torsion

    DEFF Research Database (Denmark)

    Brasso, K; Andersen, L; Kay, L; Wille-Jørgensen, P; Linnet, L; Egense, J

    1993-01-01

    Thirty-five patients were examined 6-11 years after operation for torsion of the testis. Loss of testicular tissue was significantly associated with long preoperative duration of symptoms and with low postoperative sperm counts. The sex hormones were normal in the majority of patients but there...

  2. Testicular Cancer

    Science.gov (United States)

    ... of skin behind the penis. You can get cancer in one or both testicles. Testicular cancer mainly affects young men between the ages of ... undescended testicle Have a family history of the cancer Symptoms include pain, swelling, or lumps in your ...

  3. Pineal epidermoid cyst: its surgical therapy.

    Science.gov (United States)

    McDonnell, D E

    1977-06-01

    A pineal epidermoid cyst was initially diagnosed as a pinealoma. Seven years later combined computerized axial tomography and carotid-vertebral angiography accurately delineated the location and suggested the diagnosis of this histologically benign lesion. Microsurgical technique via a right occipital transtentorial approach allowed successful intracapsular resection of this tumor. PMID:882913

  4. Intracortical epidermoid cyst of the tibia

    International Nuclear Information System (INIS)

    Epidermoid cyst in a long bone is an extremely rare condition. The authors describe such a tumor located in the cortex of the tibia in a 21-year-old woman. She was successfully treated with curettage and autogenous bone grafting. (orig.)

  5. Epidermoid cyst of clitoris mimicking clitoromegaly

    Directory of Open Access Journals (Sweden)

    Aggarwal Satish

    2010-01-01

    Full Text Available Clitoromegaly in pediatric and adolescent age group is usually indicative of a disorder of sexual differentiation. We report a girl child presenting with clitoral enlargement due to an epidermoid cyst. The cyst was excised with complete cosmetic recovery.

  6. Testicular varicoceles

    Energy Technology Data Exchange (ETDEWEB)

    Beddy, P. [Department of Radiology, Adelaide and Meath Hospital, Tallaght, Dublin 24 (Ireland); Geoghegan, T. [Department of Radiology, The Adelaide and Meath Hospital, Tallaght, Dublin 24 (Ireland); Browne, R.F. [Department of Radiology, The Adelaide and Meath Hospital, Tallaght, Dublin 24 (Ireland); Torreggiani, W.C. [Department of Radiology, The Adelaide and Meath Hospital, Tallaght, Dublin 24 (Ireland)]. E-mail: william.torreggiani@amnch.ie

    2005-12-15

    A testicular varicocele represents an abnormal degree of venous dilatation of the pampiniform plexus. It is a relatively common condition and may present at scrotal pain and swelling. An association with male subfertility is an area of debate. This article describes the present day radiological criteria and imaging techniques to aid accurate diagnosis of varicoceles. In addition, the role of the interventional radiologist in treating this condition is discussed.

  7. Carcinoma epidermoide del conducto auditivo externo

    Directory of Open Access Journals (Sweden)

    Javier Alfonso Rodríguez

    2009-02-01

    Full Text Available Acude a la consulta de Otorrinolaringología un paciente masculino de 43 años de procedencia urbana que comienza con una otorrea de larga evolución (aproximadamente dos años, para la que llevó numerosos tratamientos para la otitis externa que presentaba, con estos antecedentes y lo constatado al examen se decide realizar toma de muestra (biopsia de la zona, diagnosticándose un Carcinoma Epidermoide, del conducto auditivo externo, patología poco frecuente en nuestro medio.A 43 years-old, urban, male patient assists the consultation of Otolaryngology with a long evolving otorrea (around two years, receiving several treatments against the external otitis he suffered. With those antecedents and what we found when examining him, we decided to take a sample (biopsy of the area, diagnosing an epidermoid carcinoma of the left external canal, an infrequent pathology in our settings.

  8. Epidermoid carcinoma of the external auditory canal

    International Nuclear Information System (INIS)

    A 43 years-old, urban, male patient assists the consultation of Otolaryngology with a long evolving otorrhea (around two years), receiving several treatments against the external otitis he suffered. With those antecedents and what we found when examining him, we decided to take a sample (biopsy) of the area, diagnosing an epidermoid carcinoma of the left external canal, an infrequent pathology in our settings

  9. High-density intracranial epidermoid tumors

    International Nuclear Information System (INIS)

    An intracranial epidermoid tumor appears as a low-density lesion on CT. This is a report on 3 cases of high-density intracranial epidermoids, which had been regarded as rare. In Case 1, one continuous tumor was noted in the bilateral cerebellopontine regions. A CT scan showed homogeneous high-density zones in the bilateral cerebellopontine-angle regions, with high-density spots indicating calcifications in the prepontine region. In Case 2, the tumor existed around the medulla and in the upper cervical spinal canal; it also seemed embedded in the pons. This tumor appeared on CT as a homogeneous high-density mass. In Case 3, the tumor was thought to have originated from Meckel's cave and to extend mainly into the extradural space in the middle fossa and in the subdural space in the posterior fossa on the right. On CT, this tumor seemed to be a dumbbell-shaped, inhomogeneous high-density mass which contained some low-density areas and peripheral high-density spots indicating calcifications. An obvious contrast enhancement was noted along the margin of the tumor. In each case, dark brown contents, indicating the existence of blood components, were obtained by surgery. These blood components are assumed to be the cause of the high density on CT. Moreover, in Case 3, the microscopic findings of operated-on specimens showed intramural hemorrhage. There were neovascularities in the cyst wall due to the organization of the blood components. It was considered that the blood components in the cystic cavity were the result of a dissection of the intramural hemorrhage. The extravasation of the contrast material from the neovascularities into the extracellular space of the cyst wall was considered to be a main cause of the contrast enhancement in Case 3. Also shown was a characteristic pattern of the extension of epidermoids, a pattern which was revealed by reviewing the reported cases of epidermoids and our own cases. (author)

  10. Sublingual epidermoid cyst: a case report

    Directory of Open Access Journals (Sweden)

    Kandogan Tolga

    2007-09-01

    Full Text Available Abstract Epidermoid and dermoid cysts represent less than 0.01% of all oral cavity cysts. The cysts can be defined as epidermoid when the lining presents only epithelium, dermoid cysts when skin adnexa are found, and teratoid cysts when other tissue such as muscle, cartilage, and bone are present. In this article, we present the case of an epidermoid cyst, with an oral as well as a submental component, in an 11 year old boy who presented with complaints of a mass in the oral cavity, difficulty chewing and swallowing of solid foods for about 3 years. He was admitted to the otolaryngology department. On examination, a mass displacing the tongue superiorly and posteriorly was noticed. An MRI scan was done and showed a 40 × 35 mm well-circumscribed non-enhancing cystic mass extending from the sublingual area to the level of the thyroid notch. The content of the cyst was homogenous. On examining the neck, a firm swelling was also noticed in the submental area, extending down to the thyroid notch. Under general anesthesia and with nasotracheal intubation, the patient underwent surgical removal of the mass. Extraorally, a midline submental horizontal incision was performed through the mucosa overlying the swelling and the cyst was dissected from the surrounding tissues and removed. On histological examination, acidophilic stratum corneum and basophilic dot like staining of stratum granulosum, which is the hallmark of an epidermoid cyst, were seen. The patient did well postoperatively, and no recurrence was noticed at the 6-months follow-up.

  11. Orbital dermoid and epidermoid cysts: Case study

    Directory of Open Access Journals (Sweden)

    Veselinović Dragan

    2010-01-01

    Full Text Available Introduction. Dermoid and epidermoid cysts of the orbit belong to choristomas, tumours that originate from the aberrant primordial tissue. Clinically, they manifest as cystic movable formations mostly localized in the upper temporal quadrant of the orbit. They are described as both superficial and deep formations with most frequently slow intermittent growth. Apart from aesthetic effects, during their growth, dermoid and epidermoid cysts can cause disturbances in the eye motility, and in rare cases, also an optical nerve compression syndrome. Case Outline. In this paper, we described a child with a congenital orbital dermoid cyst localized in the upper-nasal quadrant that was showing signs of a gradual enlargement and progression. The computerized tomography revealed a cyst of 1.5-2.0 cm in size. At the Maxillofacial Surgery Hospital in Niš, the dermoid cyst was extirpated in toto after orbitotomy performed by superciliary approach. Postoperative course was uneventful, without inflammation signs, and after two weeks excellent functional and aesthetic effects were achieved. Conclusion. Before the decision to treat the dermoid and epidermoid cysts operatively, a detailed diagnostic procedure was necessary to be done in order to locate the cyst precisely and determine its size and possible propagation into the surrounding periorbital structures. Apart from cosmetic indications, operative procedures are recommended in the case of cysts with constant progressions, which cause the pressure to the eye lobe, lead to motility disturbances and indirectly compress the optical nerve and branches of the cranial nerves III, IV and VI.

  12. Quiste dermoide en la cola de la ceja

    Directory of Open Access Journals (Sweden)

    Lázara Kenia Ramírez García

    2014-03-01

    Full Text Available El quiste dermoide es un tipo de coristoma que corresponde a una anomalía congénita del desarrollo. Se presenta una transicional de dos años. Desde su nacimiento, la mamá notó un aumento de volumen a nivel de la cola de la ceja del ojo derecho, de bordes delimitados, blanda, movible, reborde orbitario libre, sin cambios de coloración, con un crecimiento acelerado clínico y ultrasonográfico en meses. Se decidió exéresis y biopsia para estudio anatomopatológico. Los resultados finales mostraron confirmación del diagnóstico de quiste dermoide en la cola de la ceja. La evolución posoperatoria fue satisfactoria sin recidiva de la lesión.

  13. Quiste de colédoco tipo IV A

    Directory of Open Access Journals (Sweden)

    Lucas Esteban Granero

    2009-01-01

    Full Text Available El quiste de colédoco tipo IV A es una enfermedad muy poco común caracterizada por una dilatación quística congénita del árbol biliar que se extiende también a los canalículos biliares intrahepáticos. Se comunica el caso de una mujer de 19 años de edad con ictericia y dolor abdominal. La paciente fue sometida a una amplia evaluación clínica, analítica y por imágenes. La tomografía computada y la colangiopancreatografía por resonancia magnética revelaron un quiste coledociano de 13.5 cm con compromiso intrahepático. Se combinó la resección de la parte extrahepática del quiste con una hepaticoyeyunoanastomosis en Y de Roux. Se descubrió una estructura ductal en la parte distal del quiste extrahepático. No hubo complicaciones perioperatorias ni alejadas en el seguimiento.

  14. Quiste óseo aneurismático Aneurysmal bone cyst

    Directory of Open Access Journals (Sweden)

    Ferdinando de Conto

    2012-06-01

    Full Text Available El quiste óseo aneurismático (QOA es una lesión benigna rara en huesos maxilares, su mayor frecuencia es en huesos largos del esqueleto y columna vertebral. Algunos autores especulan que el origen sea por trauma, mala formación o un neoplasma. El aspecto radiográfico puede mostrar desde una imagen difusa hasta una imagen bien definida, muy semejante a las otras lesiones de los maxilares volviendo el diagnóstico diferencial amplio. Con la destrucción del córtex óseo puede todavía formar una imagen reaccional del periostio en forma de rayos de sol, característico de una lesión maligna. En este estudio, se presenta caso de paciente femenino, 17 años de edad, que buscó el Servicio de Cirugía y Traumatología Buco maxilofacial del Hospital São Vicente de Paulo-RS, que presentó dolor y aumento de volumen en la mandíbula. Informó que hace cerca de un año empezó a sentir malestar en la región junto al ángulo mandibular derecho, lo cual fue progresivamente aumentando de volumen. El aspecto radiográfico acordaba una lesión maligna. Después de la confirmación histopatológica de QOA, el tratamiento seleccionado para el caso fue quirúrgico conservador, con legrado de la cavidad ósea, y fue mantenido en control posoperatorio de rutina con 6 y 18 meses. En las radiografías panorámicas realizadas se verifica la neoformación ósea y cura del caso.The aneurysmal bone cyst (ABC is a benign and rare lesion in maxillary bones, is more frequent in largo bones of skeletal and spinal column. Some authors speculate about that its origin be traumatic, malformation of neoplasm. The radiographic appearance may to show from a diffuse image up to a well defined image very similar to the other maxillary lesions turning wide the differential diagnosis. With destruction of the bon cortex it is possible to create a reaction image of periosteum in sunbeams characteristic of malignant lesion. This is the case of a female patient aged 17 seeking help in the Bucco-maxillofacial Surgery and Traumatology Service of the São Vicente de Paulo Hospital _ RS, presenting with pain and an increased mandibular volume. She manifested that around one year she began to feel a discomfort next to he right mandibular angle, which was progressively increasing the volume. The radiographic appearance resembled a malignant lesion. After the histopathology verification of ABC, treatment choosed for this case was of type conservative surgical with bone cavity curettage and was maintained under systemic postoperative control for 6 and 18 months. In the taken panoramic radiographies is verified the bone neoformation and the cure of case.

  15. CARCINOMA EPIDERMOIDE INFILTRANTE. REPORTE DE UN CASO

    Directory of Open Access Journals (Sweden)

    Héctor Oscar Victoria Bárzaga

    2007-01-01

    Full Text Available Se presenta el caso de un hombre de raza blanca, 78 años de edad, fumador inveterado, con antecedentes patológicos personales de leucoplasia del labio inferior, además de exponerse de forma prolongada a radiaciones ultravioletas, desarrolló un carcinoma epidermoide infiltrante del labio inferior con metástasis ganglionar regional. Exponemos los aspectos etiogénicos y clinicopatológicos que se describen de este tipo de cáncer cutáneo a la luz de los conocimientos actuales, así como su tratamiento, pronóstico y seguimiento.

  16. Management of Epidermoid Carcinoma of the anus

    International Nuclear Information System (INIS)

    In two unselected, consecutive and population-based patient materials from two regions in Sweden, different treatment modalities in patients with epidermoid carcinoma of the anus have been evaluated. By using a primary radiotherapeutic approach, combined with surgery in patients with large and/or less radiosensitive tumors, considerably more surviving patients can be disease-free in the long term compared with a primarily surgical approach. In addition, several patients will have preserved anal function. Based upon these data together with the experience described in the literature, we conclude that surgery is no longer the primary treatment of choice in patients with anal carcinoma. (authors)

  17. Intraosseous Epidermoid Cyst Associated with Impacted Mandibular Wisdom Teeth: An Uncommon Entity

    OpenAIRE

    Toptas, Orcun; Akkas, Ismail; TEK, Mustafa; Ozan, Fatih; Boran, Cetin

    2014-01-01

    Epidermoid and dermoid cysts of the jaws are seen rarely. The formation theories of the intraosseous epidermoid cyst (IEC) are not clear. The radiographic appearance is similar with unilocular cysts. Surgical enucleation is the suggested treatment method for epidermoid cysts. This case report presents bilateral mandibular intraosseous epidermoid cysts with impacted wisdom teeth which is the first documented case in the literature.

  18. Surgery for Testicular Cancer

    Science.gov (United States)

    ... treated? Next Topic Radiation therapy for testicular cancer Surgery for testicular cancer Surgery is typically the first ... very experienced. Possible risks and side effects of surgery The short-term risks of any type of ...

  19. Testicular Torsion (For Parents)

    Science.gov (United States)

    ... to Z: Scrotal Pain, Acute A to Z: Varicocele (Scrotal Varices) Hernias Ultrasound: Scrotum Undescended Testicles Male ... Exams How to Perform a Testicular Self-Examination Varicocele Male Reproductive System Testicular Torsion Contact Us Print ...

  20. Chemotherapy for Testicular Cancer

    Science.gov (United States)

    ... cancer Next Topic Radiation therapy for testicular cancer Chemotherapy for testicular cancer Chemotherapy (chemo) is the use of drugs to treat ... its side effects, please see, A Guide to Chemotherapy . Last Medical Review: 01/20/2015 Last Revised: ...

  1. Testicular Cancer Resource Center

    Science.gov (United States)

    ... is helping a number of researchers investigating the influence of genetics on testicular cancer. They are looking ... us. Fertility 101 --- Baby making issues in plain speak. Testicular Implants --- If you can't live without ...

  2. Testicular torsion repair

    Science.gov (United States)

    Testicular torsion repair is surgery to untangle a spermatic cord. The spermatic cord is the collection of blood vessels in the ... people will get general anesthesia for testicular torsion repair surgery. This will make you asleep and pain- ...

  3. Epidermoid cysts of the pineal region.

    Science.gov (United States)

    MacKay, C I; Baeesa, S S; Ventureyra, E C

    1999-04-01

    Localization of epidermoid cysts to the pineal region is rare. The 7-year-old boy now reported presented with an 18-month history of progressive ataxia. CT and MRI scans demonstrated a 2.5x2.5 cm cyst at the pineal region with obstructive hydrocephalus. At surgery via an occipital transtentorial approach, a characteristic "pearly tumour" was encountered, and complete resection was achieved. We present the management of this child with pineal region epidermoid cyst and review 11 cases reported in the literature since 1968. In all, 8 of the 12 patients were males. The age at the time of diagnosis ranged from 7 years to 69 years. Parinaud's syndrome and hydrocephalus are the most common presenting findings. All but 1 patient underwent direct surgical resection; 1 had stereotactic decompression. Surgical treatment brought about complete resolution of the presenting symptoms and signs in 10 of the 12 cases. One patient had persistent upgaze palsy. One patient died from progression of the pineal region mass. This patient presented with hemiparesis, which is a marker of clinical aggressiveness. The authors advocate direct surgical attack as opposed to stereotactic diagnosis and aspiration to: (1) obtain maximal resection and thereby limit the potential for recurrence and delayed complications of the cyst; (2) possibly avoid shunt placement in patients who present with hydrocephalus; and (3) decrease the likelihood of sampling error. PMID:10361967

  4. Isodense epidermoid cyst in the pineal region

    International Nuclear Information System (INIS)

    A 69-year-old male was admitted complaining of gait disturbances and diplopia, 2.5 years after an episode of serous meningitis. Neurological examination on admission disclosed Parinaud's sign, unsteady gait and dysdiadochokinesis on the left side. A striking finding on the computerized tomography (CT) was the left to right shift of the posterior portion of the third ventricle without visualization of the quadrigeminal and ambient cisterns, which were almost completely occupied by an isodense mass accompanied by high dense flecks and a low dense part. Enhanced CT showed positive enhancement in the vicinity of the pineal calcification. By the suboccipital supracerebellar approach, an encapsulated mass containing brownish yellow fluid was subtotally removed and a histological examination of it revealed epidermoid tissue and hemosiderin deposits in the solid portion. Few reports of isodense epidermoid cysts have so far been found in the literature giving a full explanation for this unusual CT attenuation value. Based on the clinical course and histology of this case, the pathogenesis of the unusual density is discussed along the following lines: The mixture of the low dense factor due to cholesterin and the high dense factor due to prior bleeding is believed to result in the isodense attenuation value in the liquid portion. Also, in the solid part, a microscopically mixed texture of deposited hemosiderin and cholesterin clefts in the inflammatory granulomatous tissue could explain its density on the CT scan. (author)

  5. Epidermoid cyst causing hemifacial spasm epidermoid cyst in cerebellopontine angle presenting with hemifacial spasm

    Directory of Open Access Journals (Sweden)

    Murat Alemdar

    2012-01-01

    Full Text Available Hemifacial Spasm (HS occurs idiopathically or secondary to the lesions compressing the root exit zone of the facial nerve symptomatically. Symptomatic HS is generally due to vascular compression. We report on a 23-year-old male with right sided HS for a month. Magnetic resonance imaging (MRI of the brain revealed a well-demarcated epidermoid cyst in the right cerebellopontine cistern. It was hypointense on T1-weighted imaging, hyperintense on T2-weighted imaging without contrast enhancement, hyperintense on DWI, and slightly hypointense on ADC relative to the brain. Although it caused shifting of the pons and medulla to the left side and compression of the right cerebellar peduncles and fourth ventricle, the sole symptom of the patient was HS. Clinicians are advised to request MRI/scan for brainstem lesions from the patients with HS. Epidermoid cysts in cerebellopontine cistern may present with HS as the sole symptom.

  6. Oral Rehabilitation of a Patient with Cerebellopontine Angle Epidermoid Cyst

    Directory of Open Access Journals (Sweden)

    Amin Nourizadeh

    2015-01-01

    Full Text Available Epidermoid cysts are rare congenital tumors of the central nervous system (CNS, histologically benign and slow- growing lesions. Their frequency among primitive intracranial tumors is about 1% and they account for 40% of all intracranial epidermoid cysts of the cerebellopontine angle (CPA; the most common symptom which brings about difficulties in oral rehabilitation of these patients is facial weakness which diversely affects impression processes and use of prosthesis. We report the oral rehabilitation of a patient with a cerebellopontine angle epidermoid cyst using neutral zone approach. Keywords: Soft tissue thickness; Facial reconstruction; Cone Beam Computed Tomography

  7. Terry Quist Greeted By Astronauts and MSFC Personnel

    Science.gov (United States)

    1972-01-01

    San Antonio, Texas high school student, Terry C. Quist, is greeted by (left to right): Astronauts Russell L. Schweickart, and Owen K. Garriott; Marshall Space Flight Center (MSFC) Skylab Program Manager, Leland Belew; and MSFC Director of Administration and Technical Services, David Newby, during a tour of MSFC. Quist was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment.

  8. Quiste Dentigero: Revisión bibliográfica y presentación de un caso

    Scientific Electronic Library Online (English)

    I, TAMI-MAURY; T, LOPEZ; Y, MOUSTARIH; N, MORETTA; G, MONTILLA; H, RIVERA.

    2000-06-01

    Full Text Available El Quiste Dentígero es el segundo quiste odontogénico más común. Generalmente está asociado con la corona de un diente normal impactado, usualmente con los terceros molares inferiores y caninos superiores. Frecuentemente se observa en pacientes del sexo masculino entre los 20 y 40 años de edad. Se p [...] resenta un caso clínico de un paciente de sexo masculino, de 53 años de edad. Se realizaron los respectivos estudios clínicos radiográficos e histopatológico. Clínicamente se observó una tumefacción no dolorosa relacionada con el canino inferior izquierdo impactado. Radiográficamente presentó un área radiolúcida multilocular de aproximadamente 7x3 centímetros de diámetro en la zona mencionada, preservando la cortical ósea. Se realizó la biopsia incisional. El diagnóstico histopatológico se correlacionó con los hallazgos clínicos y radiográficos, lo cual reveló un Quiste dentígero. Luego del diagnóstico final, la remoción quirúrgica del quiste fue llevada a cabo bajo anestesia local. Abstract in english Dentigerous cyst is the second most common odontogenic cyst. It is generally associated to a normal crown tooth usually impacted lower third molars and upper canine. It is frequently observed in male patients between 20 and 40 year-old. A clinical case of a 53 year-old male patient is presented. Cli [...] nical, radiological and histopathological studies were done. Clinically, a painless tumefaction involving the impacted mandibular left canine was noted. Radiological examination revealed a multilocular radiolucent area (7x3 centimeters in diameter), in the above mentioned location with preservation of cortical bone. Incisional biopsy was performed. The histopathological diagnosis correlated with the clinico-radiological findings disclosured a Dentigerous cyst. After final diagnosis of the leson, surgical removal of the cyst was carried out under local anesthesia.

  9. Intracranial epidermoid cyst in a horse.

    Science.gov (United States)

    Peters, M; Brandt, K; Wohlsein, P

    2003-07-01

    An intracranial epidermoid cyst was diagnosed in a Haflinger gelding aged 12 years suffering from episodes of neurological disturbance, apathy and fever. The extracerebral cyst was located in the region of the tentorium cerebelli and measured 9 x 8 x 5 cm. It displaced the cerebral hemispheres anteriorly and compressed the cerebellum and brainstem underneath. Histologically, the cyst was lined by keratinizing, stratified squamous epithelium and contained keratin scales, debris, focal haemorrhages, and degenerating inflammatory cells. The epithelium was supported by a vascularized fibrous capsule that firmly adhered to the dura mater. Multifocal haemorrhages and moderate lymphohistiocytic infiltrations were present in the capsule. The basement membrane was disrupted focally, and single or clustered cytokeratin-positive epithelial cells were detected in the fibrous capsule, suggesting a possible transition to malignancy. PMID:12859913

  10. [Radical surgical treatment of vulvar epidermoid cancer].

    Science.gov (United States)

    Attieh, E; Yazbeck, C; Abi Tayeh, G; Abboud, J

    2000-01-01

    During an eighteen-year period, forty-nine patients with invasive epidermoid carcinoma of the vulva were treated by a radical vulvectomy at the Hôtel-Dieu de France hospital in Beirut. The age, the clinical presentation, and the lymph nodes involvement were close to what was published in the literature. The overall five-year survival rate was 72%. Those with stage I disease lesions had an excellent survival rate. A review of the literature would indicate that a conservative approach in the treatment of early invasive lesions can give satisfactory results, and that adjuvant radiotherapy is more beneficial than pelvic lymph nodes dissection when there is a high risk of pelvic involvement. PMID:11268568

  11. Pineal epidermoid cyst: case report and review of the literature.

    Science.gov (United States)

    Hassani, Fahd Derkaoui; Bouchaouch, Abdelali; El Fatemi, Nizare; Gana, Rachid; El Abbadi, Najia; Maaqili, Moulay Rachid

    2014-01-01

    Intracranial epidermoid cysts are one of the rare tumors of all intracranial tumors. They represent 0,2 to 1% of intracranial tumors and 7% of tumors in the cerebellopontine angle. The pineal region is exceptionally subject to such kind of tumor. Cushing was the first to report the pineal localization of the epidermoid cyst in 1928. Up to now, 85 cases of pineal epidermoid cyst were cited in the literature. We report a clinical case concerning a 45 years old man who presented an intracranial hypertension during 18 months. The clinical examination found a hemiparesis with a facial hypoesthesis. The MRI showed a process of the pineal region. The patient underwent a surgery with a large resection. The histological examination confirms the epidermoid cyst. Many approaches were described in the literature. The outcome is related to this localization. PMID:25489364

  12. Sylvian fissure epidermoid cyst presenting with intention tremor

    Science.gov (United States)

    Shah, Abhidha; Makkiyah, Feda; Goel, Atul

    2016-01-01

    Epidermoid tumors are benign tumors which contain keratin, cellular debris, and cholesterol, and are lined with stratified squamous epithelium. They grow in discreet silence sustained over a multitude of years. The tumors most commonly present with headache and seizures. We report the case of a 24-year-old male with a large sylvian fissure epidermoid tumor who presented with intention tremor. The patient was operated, and a near-total excision of the tumor was performed with a resolution of the tremor.

  13. Quiste coloide del tercer ventrículo

    Directory of Open Access Journals (Sweden)

    Juan Dávila Meneses

    2012-09-01

    Full Text Available Los quistes coloides son lesiones intracraneales con una incidencia calculada en tres individuos por millón de personas en un año. Son tumores benignos de la porción anterosuperior del tercer ventrículo. El flujo normal del líquido cefalorraquídeo puede ser interrumpido por un gran quiste que obstruya el foramen de Monro. Los signos y síntomas asociados engloban un espectro amplio de características, desde una cefalea no específica hasta datos de hipertensión intracraneal; algunos quistes coloides se dan en el comienzo agudo de una hidrocefalia y pueden llevar a una muerte súbita. Caso: presentamos el caso de un adolescente masculino de 13 años de edad, de raza negra, quien dos días antes de su fallecimiento había manifestado cefalea. Al examen de autopsia se evidenció un quiste coloide del tercer ventrículo que produjo una hidrocefalia aguda obstructiva, con edema cerebral severo y herniación de amígdalas cerebelosas. En este artículo comentamos las características principales del quiste coloide y realizamos una breve revisión bibliográficaColloid cysts are intracranial lesions with an estimated incidence of three individuals per million people per year. They are benign tumors of the anterior portion of the third ventricle. The normal flow of cerebrospinal fluid may be interrupted by a large cyst obstructing the foramen of Monro. The signs and symptoms associated cover a wide range of features, from a non-specific headaches to intracranial hypertension data, some colloid cysts occur in the acute onset of hydrocephalus and can lead to sudden death. Case: We present the case of an adolescent male 13 years of age, black race, who two days before his death had expressed headache. On examination autopsy showed a third ventricular colloid cyst that caused acute obstructive hydrocephalus with severe cerebral edema and herniation of cerebellar tonsils. In this article we discuss the main features of the colloid cyst and performed a brief literature review

  14. Radiation Therapy for Testicular Cancer

    Science.gov (United States)

    ... chemo and stem cell transplant for testicular cancer Radiation therapy for testicular cancer Radiation therapy uses high-energy rays or particles to ... cells or slow their growth. In testicular cancer, radiation is mainly used to kill cancer cells that ...

  15. Testicular microlithiasis: Echographic diagnostic

    International Nuclear Information System (INIS)

    Testicular microlithiasis is a rare and asymptomatic condition. It can be diagnosed by scrotal ultrasound, identifying its specific appearance secondary to multiple intratubular calcifications. We report three cases of patients that were studied with ultrasound, two of them for testicular pain and one for bilateral varicocele found during clinical examination. Radiographs taken with standard mammography techniques and equipment are included, which confirm the presence of micro calcifications within the testicular parenchyma

  16. Varicocele and testicular function

    OpenAIRE

    Pastuszak, Alexander W.; Run Wang

    2015-01-01

    Testicular varicocele, a dilation of the veins of the pampiniform plexus thought to increase testicular temperature via venous congestion, is commonly associated with male infertility. Significant study has clarified the negative impact of varicocele on semen parameters and more recent work has shed light on its detrimental effects on the molecular and ultrastructural features of sperm and the testicular microenvironment, as well as more clearly defined the positive impacts of treatment on co...

  17. Epidermoid cyst of the posterior fossa: a case report Cisto epidermoide da fossa posterior: relato de caso

    Directory of Open Access Journals (Sweden)

    Eduardo Cambruzzi

    2011-02-01

    Full Text Available Epidermoid cysts of the central nervous system are uncommon conditions, which are frequently located in the cerebellopontine angle and around the pons. They are covered with keratinized squamous epithelium and keratin lamella, which give its contents a soft, white-pearly appearance. Epidermoid cysts are mostly originated from malformations, presumably associated with surface elements of the nervous system ectoderm during the closure of the neural groove or formation of secondary cerebral vesicles. The authors describe a case of epidermoid cyst in the posterior fossa causing hydrocephalus and review morphologic and diagnostic criteria of this lesion.Os cistos epidermoides do sistema nervoso central (SNC são condições incomuns, estando localizados mais frequentemente no ângulo pontocerebelar e ao redor da ponte. Eles são revestidos por epitélio escamoso queratinizado e lamelas de queratina, tornando seu conteúdo branco-perolado e pastoso. Os cistos epidermoides são, na maioria das vezes, originados de malformações, possivelmente associados ao entremeio de elementos superficiais do ectoderma do SNC durante o fechamento da placa neural, ou formação das vesículas cerebrais secundárias. Os autores descrevem um caso de cisto epidermoide da fossa posterior determinando hidrocefalia e revisam critérios morfológicos e diagnósticos dessa lesão.

  18. Quiste broncogénico infantil Infantile bronchogenic cyst

    Directory of Open Access Journals (Sweden)

    Jorge Neira M

    2004-11-01

    Full Text Available El quiste broncogénico es una anomalía congénita benigna del sistema embrionario y rara vez se diagnostica en el periodo de recién nacido. Se presenta el caso de un lactante de 10 meses hospitalizado por bronquiolitis moderada con tos, dificultad respiratoria, fiebre y vómitos causada por virus Influenza A. La radiografía de tórax mostró una imagen quística de gran tamaño en el pulmón derecho. Una vez recuperado de la bronquiolitis, se resecó quirúrgicamente. Se encontró un quiste localizado en el extremo superior del lóbulo inferior derecho que desplazaba el mediastino a izquierda y colapsaba los lóbulos medio y superior. La biopsia confirmó quiste pulmonar congénito con fibrosis cicatricial, hemorragia antigua e inflamación crónica inespecífica. El cultivo del líquido interior fue negativo. El lactante no ha vuelto a presentar síntomas respiratorios durante cuatro años después de la cirugía. Se analiza el origen, diagnóstico y manejo de los quistes broncogénicos en la infancia. Se enfatiza la importancia de la radiografía de tórax en niños con síntomas respiratoriosBronchogenic cysts are rarely diagnosed in the newborn period. It is a benign congenital anomaly of the embrionic system. We report the case of a 10 month old infant who was admitted to the hospital with a moderate bronchiolitis caused by influenza A, with cough, wheezing, fever and vomiting. Chest X-ray showed a large cyst in the right lung. He had a good evolution with only supportive measures. After recovery the cyst was removed. At surgery, the cyst was located superiorly in the right lower lobe, with left mediastinal shift and collapsed upper and middle lobes. Pathologic examination of the specimen revealed a congenital cyst with fibrosis, old hemorrhage and nonspecific inflammation. No bacterial growth was found. The infant has been symptom free during 4 years of follow-up. We review the pathogenesis, diagnosis and treatment of bronchogenic cysts in childhood and emphasize the importance of chest radiographs in bronchiolitis and chronic cough

  19. Recurrent Perianal Sinus in Young Girl Due To Pre-sacral Epidermoid Cyst

    OpenAIRE

    Jain, V.; Misra, S; Tiwari, S.; Rahul, K; H. Jain

    2013-01-01

    Pre-sacral epidermoid cysts are rare development cysts resulting from dysembryogenesis mostly diagnosed in middle aged women. We report a case of pre-sacral epidermoid cyst presenting with recurrent perianal sinus in young girl. Generally pre-sacral epidermoid cysts are seen in adult age group but it is rare presentation in young age group. We report a rare case of presacral epidermoid cyst occurring in a young female.

  20. Epidermoid cyst of the ovay in young woman: A case report

    International Nuclear Information System (INIS)

    In general, ovarian epidermoid cysts coexist with surface epithelial ovarian tumors. Pure epidermoid cysts are extremely rare diseases, comprising less than 1% of surface ovarian tumors. We present here a pathologically proven epidermoid cyst of the ovary in a young woman with ultrasonographic and magnetic resonance findings

  1. Epidermoid cyst of the ovay in young woman: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Jung Hee; Kim, See Hyung; Kang, Yu Na; Kim, Mi Jeong [Keimyung University School of Medicine, Dongsan Medical Center, Daegu (Korea, Republic of)

    2015-06-15

    In general, ovarian epidermoid cysts coexist with surface epithelial ovarian tumors. Pure epidermoid cysts are extremely rare diseases, comprising less than 1% of surface ovarian tumors. We present here a pathologically proven epidermoid cyst of the ovary in a young woman with ultrasonographic and magnetic resonance findings.

  2. Estudio de la fertilidad y viabilidad de quistes hidatídicos ovinos

    Directory of Open Access Journals (Sweden)

    García Llamazares José Luis

    1997-01-01

    Full Text Available FUNDAMENTO: La finalidad de este trabajo es analizar la fertilidad de los quistes hidatídicos de origen ovino, especie de gran interés epidemiológico en la hidatidosis, y la adecuación del gerbillo (Meriones unguiculatus como modelo experimental para el estudio "in vivo" de dicha hidatidosis, fase preliminar de posteriores estudios terapeúticos. MÉTODOS: Se ha realizado un estudio de la fertilidad y viabilidad de quistes hidatídicos procedentes de pulmones e hígados de ganado ovino de Castilla y León a través del examen y evaluación de una serie de parámetros entre los que figura la producción de una hidatidosis secundaria experimental en animales de laboratorio. RESULTADOS: El índice quístico total obtenido fue de 8,57 quistes por ovino infestado (5,97 quistes por pulmón infestado y 5,57 quistes por hígado infestado. El porcentaje de fertilidad obtenido en los quistes hidatídicos de origen ovino que contenían protoescólex viables "in vitro" fue del 43,97% (43,02% en los quistes pulmonares y 46,16% en los quistes hepáticos. La viabilidad "in vivo" de los protoescólex seleccionados se puso de manifiesto al producirse en el 100% de los gerbillos infectados una hidatidosis secundaria experimental. CONCLUSIONES: Se destaca la validez de los criterios utilizados para estudiar la viabilidad "in vitro" de los protoescólex procedentes de quistes hidatídicos de origen ovino. La hidatidosis secundaria producida en gerbillos nos conduce a considerarlos como especie de experimentación adecuada para la investigación "in vivo" de la hidatidosis de origen ovino.

  3. Intraosseous epidermoid cyst of the finger phalanx: a case report

    Directory of Open Access Journals (Sweden)

    Nipun Kalsotra

    2010-09-01

    Full Text Available Nipun Kalsotra, Manjeet Singh, Siddhartha Sharma, Dara SinghDepartment of Orthopaedics, Government Medical College Jammu, Jammu and Kashmir State, IndiaAbstract: Epidermoid cysts of the finger phalanx are rare pseudotumors. They are benign lesions with a satisfactory outcome after excision. It is important to differentiate this benign lesion, which can be easily treated by curettage, from other benign and malignant lesions of the bone with a similar clinical presentation, and which may require amputation. We describe a case of an epidermoid cyst in the distal phalanx of the ring finger. It was treated successfully and the patient had excellent functional results at one-year follow-up.Keywords: finger phalanx, epidermoid cyst, lytic bone lesion

  4. Sylvian fissure epidermoid cyst presenting with intention tremor.

    Science.gov (United States)

    Shah, Abhidha; Makkiyah, Feda; Goel, Atul

    2016-01-01

    Epidermoid tumors are benign tumors which contain keratin, cellular debris, and cholesterol, and are lined with stratified squamous epithelium. They grow in discreet silence sustained over a multitude of years. The tumors most commonly present with headache and seizures. We report the case of a 24-year-old male with a large sylvian fissure epidermoid tumor who presented with intention tremor. The patient was operated, and a near-total excision of the tumor was performed with a resolution of the tremor. PMID:27057232

  5. Dislocación testicular postraumática / Traumatic testicular dislocation

    Scientific Electronic Library Online (English)

    S., Luján Marco; A., Budía Alba; V., Bango García; M., Ramirez Backhaus; F.J., Delgado Oliva; J.F., Jiménez Cruz.

    2006-04-01

    Full Text Available Presentamos el caso clínico de un paciente politraumatizado, conductor de motocicleta, con dislocación testicular derecha. Se trata de una lesión infrecuente tras traumatismo contuso que requiere diagnóstico y tratamiento precoz con el fin de evitar la atrofia testicular. Esta lesión deberá tenerse [...] en cuenta en toda evaluación del politraumatizado, requiriendo tratamiento quirúrgico. El objetivo del caso clínico es aportar un nuevo caso a la literatura, siendo este el sexto caso publicado por autores españoles, con el fin de clarificar el manejo y tratamiento. Abstract in english Testicular dislocation is an uncommon injury after blunt scrotal trauma (with only 150 cases reported) that must be properly diagnosed and treat in order to avoid a testicular atrophy. We presented a case report of traumatic dislocation of right testicle after a motorcycle accident. This type of tes [...] ticular injury should be included in the whole evaluation of every polytrauma patient and usually requires a surgical treatment. The aim of this report is to clarify some aspects of the management of such rare entity.

  6. Quiste hidatídico primario de bazo

    Directory of Open Access Journals (Sweden)

    Juan Llatas

    2010-07-01

    Full Text Available Paciente varón de 63 años, natural y procedente de Lima. Ha estado en área ganadera hace 7 años. Su enfermedad fue insidiosa y progresiva, un mes antes del ingreso tuvo malestar y distensión abdominal, asociado a náusea y vómito ocasionales; no presentó pérdida de peso. En el examen clínico estaba lúcido y estable; no tenía ictericia. El abdomen era blando sin signos de irritación peritoneal; en el hemiabdomen izquierdo se palpaba una masa grande de límites definidos, no dolorosa, adherida a planos profundos. Resto del examen no tuvo alteraciones significativas. Exámenes auxiliares: Hemograma: Normal, eosinófilos 5.74%; examen de orina, perfil de coagulación, bioquímica y electrolitos sin alteraciones. Proteínas totales, albúmina , bilirrubinas Y transaminasas y fosfatasa alcalina sin alteraciones significativas. Arco V positivo: 248 (N<22 e Inmunoblot para Echinococcus granulosus positivo. La ecografía abdominal mostraba "dos" formaciones quísticas tabicadas de 161 x 95 mm y 146 x 130 mm, que desplazaban bazo y riñón izquierdo. La tomografía axial computarizada fue interpretada como una gran formación ovoide (12 x 18 x 27 cm dependiente de bazo, lobulada, hipodensa con áreas focales redondeadas de menor atenuación a predominio periférico y septos internos, sin realce al contraste endovenoso, compatible con quiste hidatídico Gharbi III. Intervenido quirúrgicamente se encontró un quiste hidatídico esplénico gigante: biloculado, tabicado, que ocupaba hipocondrio y flanco izquierdo de abdomen, tenía paredes gruesas, vesículas hijas y liquido claro en su interior. La lesión quística estaba adherida al colon descendente, estómago y hemidiafragma izquierdo. Se realizó quistectomía parcial mas drenaje externo; no presentó complicaciones posquirúrgicas. Presentamos este caso porque el quiste hidatídico esplénico (primario es poco frecuente, menos aún como localización única, se reporta que su prevalencia no supera el 1 %.

  7. Large and small cells non-keratinizing epidermoid vaginal carcinoma

    International Nuclear Information System (INIS)

    Five case reports of patients who were assisted at the cervix Pathology Department from 'Mariana Grajales Coello' Provincial Gynecological Obstetrical Hospital in Santiago de Cuba due to vaginal bleeding, low abdominal pain, leukorrhea and vaginal injuries are presented. The pathological study confirmed the diagnosis of squamous or epidermoid cells carcinoma

  8. Testicular calculus: A rare case

    Directory of Open Access Journals (Sweden)

    Volkan Sen

    2015-06-01

    Full Text Available ABSTRACTBackground:Testicular calculus is an extremely rare case with unknown etiology and pathogenesis. To our knowledge, here we report the third case of testicular calculus. A 31-year-old man was admitted to our clinic with painful solid mass in left testis. After diagnostic work-up for a possible testicular tumour, he underwent inguinal orchiectomy and histopathologic examination showed a testicular calculus.Case hypothesis:Solid testicular lesions in young adults generally correspond to testicular cancer. Differential diagnosis should be done carefully.Future implications:In young adults with painful and solid testicular mass with hyperechogenic appearance on scrotal ultrasonography, testicular calculus must be kept in mind in differential diagnosis. Further reports on this topic may let us do more clear recommendations about the etiology and treatment of this rare disease.

  9. Segmental ischemia in testicular torsion

    OpenAIRE

    Tavasl?, Binnur; Köseo?lu, Hikmet; Çevik, Halime

    2016-01-01

    Testicular torsion is a rare but important entity in the discipline of urology, as urgent action is required to save the testicle anatomically and functionally. Occurring mainly in the young prepubertal or pubertal male, testicular torsion is also seen in young adults. The annual incidence has been estimated to be 4.5 cases per 100,000 male subjects. The outcome of testicular torsion, in cases of unsuccessful emergent intervention, is total or partial infarction of the testicular tissue. We p...

  10. Varicocele and testicular function

    Directory of Open Access Journals (Sweden)

    Alexander W Pastuszak

    2015-01-01

    Full Text Available Testicular varicocele, a dilation of the veins of the pampiniform plexus thought to increase testicular temperature via venous congestion, is commonly associated with male infertility. Significant study has clarified the negative impact of varicocele on semen parameters and more recent work has shed light on its detrimental effects on the molecular and ultrastructural features of sperm and the testicular microenvironment, as well as more clearly defined the positive impacts of treatment on couples? fertility. The relationship between varicocele and testicular endocrine function, while known for some time based on histologic evaluation, has become more apparent in the clinical setting with a growing link between varicocele and hypogonadism. Finally, in the pediatric setting, while future study will clarify the impact of varicocele on fertility and testicular function, recent work supports a parallel effect of varicocele in adolescents and adults, suggesting a re-evaluation of current treatment approaches in light of the progressive nature of the condition and potential increased risk of future disease.

  11. Intraosseous epidermoid cysts in the distal phalanx of two dogs

    International Nuclear Information System (INIS)

    Two dogs were presented with a history of lameness associated with swelling of one of the digits. Radiographs of the affected digits revealed an irregularly mineralized, smoothly marginated proliferative bone lesion in the distal phalanx of one dog and a destructive bony lesion in the distal phalanx of the second dog. The differential diagnosis included nail bed carcinoma, malignant melanoma, osteomyelitis, and subungual keratoacanthoma. Radiographic findings and no response to medical treatment resulted in amputation and submission of the digits for a histopathologic diagnosis. Histologic examination of the distal phalanx of the digits revealed benign epidermoid cysts associated with either bony proliferation or osteolysis. Excision of the lesions was curative. This report presents the clinical, radiographic, and histopathologic findings associated with intraosseous epidermoid cysts in the distal phalanx of two dogs

  12. Treatment of epidermoid tumors with gamma knife radiosurgery: Case series

    OpenAIRE

    Javier A Jacobo Vasquez; Julio R Fonnegra; Juan C Diez; Andres Fonnegra

    2016-01-01

    Background: Epidermoid tumors (ETs) are benign lesions that are treated mainly by means of surgical resection, with overall good results. External beam radiotherapy is an alternative treatment for those recurrent tumors, in which a second surgery might not be the best choice for the patient. A little information exists about the effectiveness of gamma knife radiosurgery for the treatment of newly diagnosed and recurrent ETs. We present three cases of ETs treated with gamma knife radiosurgery....

  13. Cerebellopontine angle epidermoid cysts: clinical presentations and surgical outcome.

    Science.gov (United States)

    Hasegawa, Mitsuhiro; Nouri, Mohsen; Nagahisa, Shinya; Yoshida, Koichiro; Adachi, Kazuhide; Inamasu, Joji; Hirose, Yuichi; Fujisawa, Hironori

    2016-04-01

    Epidermoid cysts constitute less than 1 % of intracranial tumors with the majority of them involving cerebellopontine angle (CPA). Although several mechanisms for cranial nerve dysfunction due to these tumors have been proposed, no direct evaluation for hyper- or hypoactive dysfunction has been done. In this case series, pathophysiology of cranial nerve dysfunction in CPA epidermoid cysts was evaluated with special attention to a new mechanism of capsule strangulation caused by stratified tumor capsule. Twenty-two cases with epidermoid cysts of CPA micro-neurosurgically treated in our departments since 2005 were reviewed. Clinical status of the patients before the surgery and post-operative functional outcome were recorded. Available data from the English literature were summarized for comparison. Mass reduction of cyst contents in most cases was usually associated with prompt and marked improvement of the symptoms suggesting neuroapraxia caused by compression of the tumor content and/or mild ischemia. Among them, two cases showed strangulation of the affected nerves by the tumor capsule whose preoperative dysfunction did not improve after surgery in spite of meticulous microsurgical removal of the lesion. Involved facial and abducent nerves in these two cases showed distortion of nerve axis and nerve atrophy distal to the strangulation site. We report the first direct evidence of etiology of cranial nerve dysfunction caused by cerebellopontine angle epidermoid tumors. Young age and rapidly progressive neurological deficit might be the characteristics for strangulation of the affected nerves by the cyst capsule. Even though the number of cases might be limited, immediate decompression and release of the strangulating band might be urged in such patients to prevent irreversible deficits. PMID:26566990

  14. Squamous cell carcinoma arising in an intradiploic epidermoid cyst

    Energy Technology Data Exchange (ETDEWEB)

    Bretschneider, T.; Dorenbeck, U.; Strotzer, M. [Department of Radiology, University Hospital, D-93042 Regensburg (Germany); Roth, M. [Clinic for Neurosurgery, University Hospital, Regensburg (Germany); Ruemmele, P.; Buettner, R. [Department of Pathology, University Hospital, Regensburg (Germany)

    1999-08-01

    A 71-year-old woman presented with the symptoms of a posterior cranial fossa mass. CT and MRI revealed a lytic lesion in the occipital bone and a tumour infiltrating the dura mater, venous sinuses and cerebellum. Histopathology demonstrated a moderately differentiated squamous cell carcinoma arising from a primarily intradiploic epidermoid cyst. Despite surgery and radiotherapy, the tumour progressed and the patient died 1 year later. (orig.) With 4 figs., 11 refs.

  15. Spontaneous nontraumatic epidermoid cyst of the clitoris: a rare case report

    Directory of Open Access Journals (Sweden)

    Arun Nayak

    2015-12-01

    Full Text Available Epidermoid cysts are slow growing, intradermal or subcutaneous tumors with a wall composed of true epidermis. They are rarely seen in the clitoral region but when found; they are commonly seen following female genital mutilation. Spontaneous onset clitoral epidermoid cysts have been scarcely reported .We report a rare case of a large spontaneous nontraumatic epidermoid cyst of clitoris in a 22 year old nulliparous female. This presentation mimicked clitoromegaly but was diagnosed to be a large epidermoid cyst after excision. [Int J Reprod Contracept Obstet Gynecol 2015; 4(6.000: 2081-2083

  16. Quiste de conducto de Skene en niñas: A propósito de 2 casos clínicos

    Directory of Open Access Journals (Sweden)

    Alberto Miño Barrera

    2014-10-01

    Full Text Available Introducción: El quiste del conducto de Skene, se describe dentro de los quistes parauretrales, siendo una rara anomalía congénita descrita en neonatos de sexo femenino, que se puede presentar en el transcurso de la vida. La incidencia varía de 1 cada 2.000-3.000 recién nacidos vivos femeninos. Objetivo: Dar a conocer las características y formas de presentación del quiste del conducto de Skene en distintas etapas del desarrollo del niño para su sospecha y diagnóstico oportuno. Casos clínicos: Se presenta una recién nacida con una lesión tumoral amarillenta, adyacente al meato uretral, no dolorosa, que drena espontáneamente y un segundo caso de una adolescente que consulto por leucorrea de un año de evolución, con una lesión parauretral de tres centímetros de diámetro entre labios menores, que requirió tratamiento quirúrgico y estudio de la masa parauretral. Conclusiones: Basado en la revisión de la literatura, concluimos que la frecuencia de los quistes de conducto de Skene es más alta que el número de casos informados. La extirpación, marsupialización, la punción y aspiración del quiste son todos métodos eficaces de tratamiento. El drenaje espontáneo también es una conducta apropiada en ciertos casos. Se sugiere utilizar la técnica menos agresiva acorde a cada caso.

  17. Quiste broncogénico cervical: Reporte de un caso Cervical bronchogenic cyst: Report of one case

    Directory of Open Access Journals (Sweden)

    JUAN ANTONIO PÉREZ P

    2008-02-01

    Full Text Available Los quistes broncogénicos son malformaciones congénitas del árbol traqueobronquial que se ubican preferentemente en pulmones y mediastino, siendo excepcional su aparición en el cuello. Esta situación conlleva que ante una masa cervical de esta naturaleza se postulen diferentes diagnósticos clínicos de lesiones cervicales que son más corrientes, tales como quiste tiroideo, tirogloso, branquial y tímico, entre otros. La imagenología informa sobre el carácter quístico de la lesión pero no proporciona hallazgos específicos. Durante la intervención quirúrgica tampoco es posible establecer el diagnóstico, puesto que la masa simula los quistes cervicales congénitos más frecuentes. El diagnóstico definitivo se establece mediante la biopsia al constatar en la pared del quiste epitelio respiratorio. Comunicamos el caso de una mujer que presentó un quiste broncogénico de ubicación cervical y discutimos algunos aspectos de esta interesante condiciónBronchogenic cysts are congenital malformations of the tracheobronchial tree that are mainly located in the lungs and mediastinum. Occasionally, they can appear in the neck, generating a cervical mass. Pathology gives the definitive diagnosis. We report a 19 years old female that consulted for an asymptomatic central cervical mass. On examination, a 4 cm diameter painless suprasternal nodule was palpated. Cervical ultrasound and CAT scan showed a cystic lesion. The cyst was completely excised surgically and the pathological report disclosed a bronchogenic cyst

  18. Testicular Cancer and Cryptorchidism

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    AlexanderIAgoulnik

    2013-03-01

    Full Text Available The failure of testicular descent or cryptorchidism is the most common defect in newborn boys. The descent of the testes during development is controlled by insulin-like 3 peptide and steroid hormones produced in testicular Leydig cells, as well as by various genetic and developmental factors. While in some cases the association with genetic abnormalities and environmental causes has been shown, the etiology of cryptorchidism remains uncertain. Cryptorchidism is an established risk factor for infertility and testicular germ cell tumors (TGCT. Experimental animal models suggest a causative role for an abnormal testicular position on the disruption of spermatogenesis however the link between cryptorchidism and TGCT is less clear. The most common type of TGCT in cryptorchid testes is seminoma, believed to be derived from pluripotent prenatal germ cells. Recent studies have shown that seminoma cells and their precursor carcinoma in situ cells express a number of spermatogonial stem cell (SSC markers suggesting that TGCTs might originate from adult stem cells. We review here the data on changes in the SSC somatic cell niche observed in cryptorchid testes of mouse models and in human patients. We propose that the misregulation of growth factors' expression may alter the balance between SSC self-renewal and differentiation and shift stem cells towards neoplastic transformation.

  19. Quiste hidatídico hepático a propósito de un caso

    Scientific Electronic Library Online (English)

    Clavo, María Luisa; Lloeznaly, Ochoa; Julio, Vargas; Belkisyolé, de Noya; Carmen, Zuramay.

    2007-09-01

    Full Text Available Se reporta el caso de paciente femenina de 51 años, con antecedente de contacto con animales domésticos, a la cual se le realizó diagnóstico de quiste hidatídico hepático, en base a estudios de imagen y paraclínicos compatibles por patrón ecográfico, con gran Lesión de Ocupación de Espacio (LOE) quí [...] stica, multivesicular, de aspecto septado, en lóbulo hepático derecho, eosinofilia moderada y discreta elevación del perfil bioquímico hepático, con Elisa (IgG) para hidatidosis positivo, que manifestó buena respuesta a terapia farmacológica única con benzimidazoles (Albendazol) vía oral, con disminución progresiva de la lesión hasta su total desaparición, sin requerir tratamiento quirúrgico, en seguimiento actual de 13 meses. Se revisa la literatura de la enfermedad y manejo terapéutico de la misma. Abstract in english We report the case of a 51 years old female patient, with a history of contact with domestic animals, to whom we diagnosed a Hepatic Hydatid Cyst, on the grounds of image studies and laboratory tests compatible with a spaceoccupying lesion, multivesicular cysts, in the right hepatic lobe; moderate e [...] osinophilia, and a discreet elevation of the hepatic biochemical profile, with Elisa (IgG) positive for Hydatid Cyst disease. She showed a good response to single therapy with benzimidazole (Albendazole), given orally, with a progressive diminution of the lesion until its total disappearance, without requiring surgical treatment, at follow up for 13 months. We review the literature relative to this disease and its therapeutic options.

  20. Quiste de Baker en el curso de la artritis reumatoidea

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    José Pedro Martínez Larrarte

    2000-03-01

    Full Text Available Se presentó un caso con diagnóstico de artritis reumatoidea seropositiva, de un año de evolución, que llevó tratamiento con aines y metotrexate, a pesar de lo cual, mantuvo actividad inflamatoria articular en el nivel de carpos y rodillas, que desarrolló un aumento de volumen de la región posterior de ambas piernas, con dolor espontáneo y signo de Homans positivo. Se valoró la posibilidad inicial de una tromboflebitis de la región poplítea y se llegó a la conclusión que se trataba de un quiste de Baker.A case with diagnosis of seropostive rheumatoid arthritis and a year of evolution was presented. The patients was treated with non-steroidal anti-inflammatories and methotrexate. In spite of this, the inflammatory articular activity was maintained at the level of the carpus and knees and there was a volume increase in the posterior region of both legs, with spontaneous pain and positive Homan´s sign. At first, it was evaluated the possibility of a thrombophlebitis of the popliteal region, but, finally, it was considered as a Baker´s cyst.

  1. Quistes del rafe medio del pene. Presentación de dos casos

    Directory of Open Access Journals (Sweden)

    Niurka García Sosa

    2014-08-01

    Full Text Available Los quistes del rafe medio del pene son lesiones benignas, infrecuentes en urología pediátrica, y usualmente asintomáticos. Se localizan en la región parameatal y borde inferior del prepucio. Se presentaron dos casos que acudieron a consulta de Urología, por el hallazgo del quiste por parte de los padres de los pacientes. Ambos quisten tenían de 1 a 2 cm de diámetro. Ninguno de los casos reportados se les había realizado la circuncisión previamente. A los dos casos se les hizo la marsupialización del quiste mediante cirugía ambulatoria, siendo la evolución post operatoria satisfactoria.

  2. Quistes del rafe medio del pene. Presentación de dos casos

    OpenAIRE

    Niurka García Sosa; Francisco J Fong Aldama

    2014-01-01

    Los quistes del rafe medio del pene son lesiones benignas, infrecuentes en urología pediátrica, y usualmente asintomáticos. Se localizan en la región parameatal y borde inferior del prepucio. Se presentaron dos casos que acudieron a consulta de Urología, por el hallazgo del quiste por parte de los padres de los pacientes. Ambos quisten tenían de 1 a 2 cm de diámetro. Ninguno de los casos reportados se les había realizado la circuncisión previamente. A los dos casos se les hizo la marsupializa...

  3. Testicular cancer and intellectual disability

    OpenAIRE

    Sasco, Annie,; Ah-Song, Roland; Nishi, Motoi; Culine, Stéphane; Réthoré, Marie-Odile; Satgé, Daniel

    2008-01-01

    The frequency of testicular cancer in men with intellectual disabilities is not precisely known, with the exception of some genetic conditions such as Down syndrome, where it has increased. Objective: To review systematically the literature through Pubmed with a particular focus on epidemiological studies of testicular cancer in persons with intellectual disability. Method: Literature review. Results: Testicular cancer was more frequent in subjects with intellectual disability than in the gen...

  4. QUISTE PARAOVARICO COMPLICADO: CAUSA RARA DE DOLOR ABDOMINAL

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    Ester Ureta H

    2007-01-01

    Full Text Available Se presentan los hallazgos ultrasonográficos y laparoscópicos en un caso de quiste paraovárico torcido correspondiente a una hidátide de Morgagni sin compromiso de la trompa ni del ovario. La paciente de 11 años consultó, al servicio de urgencia por un dolor abdominal agudo que hizo plantear clínicamente la existencia de una apendicitis aguda. La identificación de un apéndice y ovarios normales, junto al hallazgo de una estructura quística compleja próxima al ovario llevaron a la cirugía laparoscópica que identificó la hidátide torcida a derecha y una estructura quística similar no torcida a izquierda. Se discute esta patología como una eventual y rara causa de dolor abdominal agudo en el sexo femenino: We report the ultrasonographic and laparoscopic findings in a case of twisted parovarian cyst related with a Morgagni hydatid, without involving of the tube and ovary. The 11 years old patient consulted for an acute abdominal pain that made suspect the clinical existence of acute appendicitis. The identification of normal appendix and ovaries, and the finding of a complex cyst structure close to the ovary, led to the laparoscopic surgery, that identified a twisted hydatid at the right side and a non twisted cystic structure at the left side. We discuss this pathology as an eventual and rare cause of acute abdominal pain in females

  5. Mesotelioma Maligno Testicular

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    Antonio Lara Torrico

    2011-06-01

    Full Text Available El mesotelioma maligno es un tumor adenomatoide de la línea de células no germinales, una neoplasia testicular muy rara, tan solo unos 100 casos han sido reportados en la literatura y la mayoría de los pacientes con este problema son mayores de 50 años. Más del 50% tienen el antecedente de exposición a los asbestos. Todos los pacientes con sospecha de un tumor maligno testicular deben someterse a una orquiectomía radical para evitarrecidivas. Presentamos el caso clínico de un paciente de sexo masculino de 69 años de edad que acudió a consulta con un cuadro de 6 meses de evolución con aumento de volumen del escroto izquierdo y drenaje de líquido serohemático a través de un orificio fistuloso. Al paciente se le realizó el tratamiento quirúrgico mediante orquiectomía radical más hemiescrotectomía izquierda y finalmente el examen histopatológico evidenció un mesotelioma maligno testicular mixto.

  6. Leech therapy for epidermoid cysts and review of the literature

    OpenAIRE

    Abbas Rasi; Alireza Faghihi; Mirhadi Aziz Jalali; Abbas Zamanian; Gholamhossein Ghaffarpour

    2014-01-01

    Hirudo medicinalis sucks blood directly through the external mammalian skin. We recently observed a healthy 64-year-old Iranian man, who presented with numerous asymptomatic multilobular oval-to-round well-defined 0.5 to 1.5 cm cystic lesions with central umbilication (central black eschar) over the upper portion of his chest. We made the diagnosis of epidermoid cyst, giant comedone and leech bite on the basis of the constellation of clinical features. The patient was treated with oral ciprof...

  7. MANEJO LAPAROSCOPICO CONSERVADOR DE QUISTE DERMOIDE CONTENIENDO UNA MANDIBULA Y 13 DIENTES

    Directory of Open Access Journals (Sweden)

    Jaime Zarhi T.

    2002-01-01

    Full Text Available Se presenta un caso clínico de quiste dermoide abordado en forma conservadora vía laparoscópica conteniendo maxilar superior y trece dientes, se discute su cuadro clínico, diagnóstico y tratamientoA case is presented of conservative laparoscopic excision of an ovarian dermoid cyst which contained a superior mandible with thirteen teeth. The clinical issue, diagnosis and treatment are discussed

  8. MANEJO LAPAROSCOPICO CONSERVADOR DE QUISTE DERMOIDE CONTENIENDO UNA MANDIBULA Y 13 DIENTES

    Scientific Electronic Library Online (English)

    Jaime, Zarhi T.; Juan M., Toso L..

    Full Text Available Se presenta un caso clínico de quiste dermoide abordado en forma conservadora vía laparoscópica conteniendo maxilar superior y trece dientes, se discute su cuadro clínico, diagnóstico y tratamiento [...] Abstract in english A case is presented of conservative laparoscopic excision of an ovarian dermoid cyst which contained a superior mandible with thirteen teeth. The clinical issue, diagnosis and treatment are discussed [...

  9. QUISTE DE INCLUSIÓN EPIDÉRMICO VULVAR COMO COMPLICACIÓN TARDÍA DE CIRCUNCISIÓN RITUAL

    Directory of Open Access Journals (Sweden)

    Jorge Andrés Robert S

    2010-01-01

    Full Text Available Presentamos un caso de quiste de inclusión epidérmico, como complicación tardía, en una mujer africana con antecedente de mutilación genital tipo II o clitoridectomía total, durante su infancia.We report a case of epidermal inclusion cyst as a late complication in an African woman with history of ritual genital mutilation type II or total excision during childhood.

  10. Comportamiento del quiste branquial en pacientes del Hospital General Docente "Ciro Redondo García", Artemisa, 1993-2009

    OpenAIRE

    Juan Carlos Quintana Díaz; Josefa Dolores Miranda Tarragó; Mayrim Quintana Giralt

    2012-01-01

    El quiste branquial de origen congénito que aparece en la región lateral del cuello es, con frecuencia, motivo de consulta. Se tuvo como objetivo determinar el comportamiento de los quistes branquiales en el Hospital "Ciro Redondo García", de Artemisa en el periodo de 1993 al 2009. Se realizó un estudio descriptivo transversal de los quistes branquiales diagnosticados en pacientes intervenidos quirúrgicamente en el Servicio de Cirugía Maxilofacial. Se estudiaron la edad, el sexo, el color de ...

  11. Epidermoid gastric cancer review literature a case study

    International Nuclear Information System (INIS)

    Full text: introduction. epidermoid epidemiologic ally gastric cancer etiology is extremely uncommon forming a 0.04 to 0.07% of cases. target. reviewing the literature from a clinical case of a female patient 60 years epidermoid carrier loco regionally advanced gastric cancer. methodology and methods. analyze the case of gastric cancer squamous which TB diagnosed n2 m0 be a eiiic. results. the case was presented as an atypical dyspepsia was diagnosed with cancer gastric squamous after taking multiple biopsies. diagnosis is confirmed and the checked laparoscopically resectable liver infiltration, commitment vascular and pancreatic seen by ct scan. it was decided to establish treatment palliative chemotherapy based on docetaxel, 5-fluorouracil and cisplatin that fails to receive and who dies of massive haematemesis. conclusions. it is well established the pathogenesis of this disease. in series reported we found a higher incidence in males, with a median age presentation at age 64. the most common is the fun dus and diagnosis in advanced stages is most prevalent. being a rare histological subtype as there is no evidence to support a massed different therapeutic adenocarcinoma

  12. Factors Predicting Testicular Atrophy after Testicular Salvage following Torsion.

    Science.gov (United States)

    Lian, Bertrand S Y; Ong, Caroline C P; Chiang, Li Wei; Rai, Rambha; Nah, Shireen Anne

    2016-02-01

    Introduction?Testicular atrophy (TA) is a significant complication in patients who undergo salvage procedures for testicular torsion. Studies on outcome focus on factors predicting testicular viability during scrotal exploration but few assess factors predicting TA in patients who undergo salvage procedures. We assess the incidence of TA after salvage and identify associated factors. Materials and Methods?With ethical approval, we reviewed patients who underwent salvage for testicular torsion in our institution from 2001 to 2013. Data was collected on patient demographics, duration of pain, sonographic findings, postoperative complications, and follow-up assessment of TA (defined as difference in testicular volume?>?50% compared with the contralateral testis, based on measurement by Prader orchidometer or by ultrasound). We excluded patients with torted undescended testis, those under 1?month, and those with follow-up??1 day (p?=?0.004) and heterogeneous echogenicity on ultrasound (p?=?0.001). Sonographic evidence of reduced vascularity was not predictive. Of 11 that had pain?>?1 day, 10 (91%) had TA. No testes survived when pain ? 3 days. Conclusion?Half of patients with testicular torsion undergoing salvage surgery will develop testicular atrophy, even when intraoperatively assessed as viable, and should be counseled accordingly. Duration of pain?>?1 day and sonographic heterogeneous echogenicity are predictive. Salvage rates are dismal when duration of symptoms exceeds 1 day. PMID:26509312

  13. Studies of testicular function after treatment for testicular tumor, 1

    International Nuclear Information System (INIS)

    Recently, the treatment for testicular tumor has improved. Preservation of testicular function in the treatment of testicular tumor is important, because the majority of the patients are young. We investigated the testicular function of patients with testicular tumor before, during and after treatment. As a part of this study, the fertility of patients with testicular tumor before and after treatment was evaluated. 1. Fourteen of 78 married patients (18 %) showed sterility for two or more years before treatment. 2. When semen was examined in 31 patients before treatment, only seven patients (23 %) showed normal sperm counts of more than 40 x 106/ml, and 19 (61.3 %) showed oligospermia or azoospermia with sperm counts of less than 10 x 106/ml. 3. Of 20 patients who underwent retroperitoneal lymphnode dissection, 15 developed ejaculation deficiency. Four other patients also developed ejaculation deficiency but recovered, and three of them rendered their wives pregnant. 4. Of 23 patients given radiotherapy, nine produced children both before and after treatment, nine produced children before treatment but showed sterility after treatment, and five showed sterility both before and after treatment. 5. Examination of semen was performed in 17 patients given radiotherapy and in five given chemotherapy. Many patients developed oligospermia or azoospermia after the treatments, but revealed a tendency to recover with time. Based on the results mentioned above, it is inferred that the ability to produce sperm in patients with testicular tumor after treatment decreases but the decrease tends to recover to normal with time. (author)

  14. Epidermoid cyst of the floor of the mouth. A case report and literature review

    Directory of Open Access Journals (Sweden)

    Rojas-Madrigal A

    2012-02-01

    Full Text Available Dermoid and epidermoid cysts are cystic benign, slightly common malformations that may be found in the area of head and neck between 1.6 and 7 %, representing less than 0.01 % of all the cysts of the oral cavity. This pathology is important of the knowledge of the professional in dentistry and medicine to be able to do the early diagnose and the respective treatment. The purpose of this study is the review of the relevant literature of the dermoid and epidermoid cysts and the presentation of a case of epidermoid cyst in floor of mouth in a patient of 13 years and 5 months of age.

  15. Testicular cytology in azoospermia

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    Usha Prasad

    2015-06-01

    Results: The commonest group with infertility were in the age group 21-30 years. The testicular size was normal in 87.17% of subjects and 12.82% had small testis. Out of 39 subjects with azoospermia 38.46% subjects had varicocele. Varicocele was commonly associated with duct obstruction. The commonest causes observed in cases with azoospermia were; hypospermatogenesis with maturation arrest (4/39,10.25%, duct obstruction (12/39,30.76%, maturation arrest (7/39,17.94%, testicular atrophy (10/39,25.64% and sertoli cell only syndrome (2/39,5.12%. In the present study diagnostic accuracy was 89.18%. Conclusions: Fine needle aspiration cytology is as informative as biopsy and can be done as a routine procedure. It helps us in ruling out obstructive and non-obstructive causes for azoospermia. In cases where FNAC shows normal spermatogenesis with azoospermia, biopsy and Doppler study is indicated to rule out duct obstruction which can be corrected surgically. It is a simple and cost effective. [Int J Reprod Contracept Obstet Gynecol 2015; 4(3.000: 647-652

  16. TESTICULAR FEMINISING SYNDROME

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    Vijay Kumar

    2014-03-01

    Full Text Available Testicular feminization syndrome is a form of pseudohermaphroditism where phenotypic female has male gonads and is genotypically male. Androgen insensitivity syndrome (AIS, also known as testicular feminization, encompasses a wide range of phenotypes that are caused by numerous different mutations in the androgen receptor gene. AIS is an X-linked recessive disorder that is classified as complete, partial based on the phenotypic presentation. The clinical findings include a female type of external genitalia, 46-XY karyotype, absence of Mullerian structures, presence of Wolffian structures to various degrees, and normal to high testosterone and gonadotropin levels. The syndrome is illustrated by a 24-year-old phenotypic female who presented with a primary amenorrhea, female-type external genitalia, an absent uterus and ovaries, and bilateral testes at the level of the internal inguinal ring. Management includes counseling, gonadectomy to prevent primary malignancy in undescended gonad, and hormone replacement. The karyotyping of family members is advocated because of known familial tendencies.

  17. Testicular biopsy in prepubertal boys

    DEFF Research Database (Denmark)

    Faure, Alice; Bouty, Aurore; O'Brien, Mike; Thorup, Jorgen; Hutson, John; Heloury, Yves

    2016-01-01

    No consensus exists regarding the precise role of testicular biopsy in prepubertal boys, although it is considered useful for assessing the potential consequences of undescended testes on fertility. Current scientific knowledge indicates that surgeons should broaden indications for this procedure...... preservation of fertility after gonadotoxic chemotherapy - even for prepubertal boys - are emerging. Cryopreservationof testicular tissue samples for the preservation of fertility - although still an experimental method at present - is appealing in this context. In our opinion, testicular biopsy in prepubertal...... boys is a minor procedure that can provide valuable information for predicting the risk of malignancy and fertility, and might be useful in fertility preservation in the near future....

  18. Intracranial epidermoid cyst causing recurrent chemically-induced meningitis

    International Nuclear Information System (INIS)

    We present a patient with a epidermoid cyst (EC) located in the prepontine and prebulbar region. The presenting sign was recurrent chemically-induced meningitis. We show the computed tomography (CT) and magnetic resonance (MR) findings. The tumor presented two neuroradiological features of interest. On the one hand, it was impossible to diagnosis it on the basis of the CT study owing to the artifact introduced by the petrous structures at the cranial base. Some of the features of the EC presented here are unusual in this type of lesions. For example, at the same time in the same tumor there are two areas with different compositions which, in the MR study, were found to having clearly different signals. (Author) 9 refs

  19. Perspectives for the treatment of epidermoid oesophageal cancer

    International Nuclear Information System (INIS)

    Prior to the eighties, most patients with a diagnosis of epidermoid oesophageal cancer only received palliative symptomatic care. To date, most all undergo either surgery or medical treatment or both. Late diagnosis due to lack of clinical signs in the early phases of the disease, and perhaps insufficient attempts at identifying patients at risk who could benefit from systematic screening, is still an important problem although the number of diagnosed cases continues to rise (from 104 in 1985 to 151 in 1989 in Finistere in western France). Two different therapeutic attitudes could improve the prognosis: extensive surgery as proposed by the Japanese with dissection of all invaded lymph nodes whatever the localization and a multimodal approach combining radiochemotherapy and surgery. Although outcome can apparently be improved in certain types of oesophageal cancer, the proposal of aggressive extensive dissection could have an effect on respiratory complications and would not necessarily be adapted to the risk involved in western patients. Certain teams have nevertheless taken this route and will soon report their results. In France two phase II trials combining radiotherapy, chemotherapy (cisplatinium) and surgery have reported encouraging results with complete sterilization in 24% of the cases and 50% survival at 18 months. In our own series of 68 patients, we have obtained 41% sterilization and 56,3% survival at 3 years with the multi-modal protocol. The high number on non-responders to chemotherapy emphasizes the importance of maintaining surgical resection whenever possible. The discouraging reports published before 1980 have been contradicted by improvements in outcome achieved over the last decade. Today, all patients with a diagnosis of epidermoid cancer of the oesophagus should benefit from either palliative or curative care based on the latest advances in radiotherapy, chemotherapy and surgery. (author). 10 refs

  20. Intradural Epidermoid Cyst at Conus Medullaris and Cauda Equina of the Spine: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Mn Woo; Lee, Ji Hae; Cho, Woo Ho [Dept. of Radiology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of)

    2012-02-15

    Spinal epidermoid cysts occur as a result of anomalous implants of epidermal cells within the spinal cord. Spinal epidermoid cysts comprise < 1% of all intraspinal mass lesions and may be congenital or acquired. Congenital lesions usually occur at conus or cauda equina, and the latter usually occur at lower lumbar spine. The typical MR appearance of a spinal epidermoid cyst is a hypointense signal lesion on T1-weighted images and a hyperintense signal lesion on T2-weighted images. However, atypical imaging features also have been reported. In this article, we report atypical MR findings of an intradural epidermoid cyst at conus medullaris and cauda equina of the spine that was caused by internal cystic hemorrhage.

  1. En las enfermedades intersticiales difusas,¿todos los quistes son realmente quistes? Diffuse interstitial diseases: are all cysts real cysts?

    Directory of Open Access Journals (Sweden)

    Juan Carlos Spina

    2010-04-01

    Full Text Available Propósito: Demostrar que los cortes axiales de tomografía computada de alta resolución (TCAR son insuficientes para una correcta evaluación de las enfermedades pulmonares intersticiales difusas y que adicionar Proyección de Mínima Intensidad (MinIP aumenta la especificidad del diagnóstico. Material y Métodos: Estudios previos donde se observaban quistes pequeños subpleurales se seleccionaron 39 TCAR de 33 pacientes con colagenopatías confirmadas y 6 con enfermedad intersticial idiopática y se los reexaminó entre octubre de 2008 y junio de 2009. El equipo utilizado fue un tomógrafo computado multislice Philips Brillance de 16 canales. Los cortes fueron de 1 mm de espesor, de ápices a bases. La evaluación se realizó con la técnica habitual, adicionando la MinIP en cortes axiales, sagitales y coronales, con rotación del parénquima y especial atención en las áreas que presentaban quistes. Se efectuaron además cortes en espiración. Resultados: De 20 TCAR que mostraban quistes subpleurales con la técnica habitual, 14 (70% correspondieron a bronquioloectasias. En 12 casos, todas las imágenes eran bronquioloectasias; en 2 casos, ellas predominaban, observándose también quistes aislados. Se pudo definir la existencia de quistes verdaderos en 6 casos (30%, todos con Neumonitis Intersticial Usual (NIU. Valor predictivo positivo (VPP de la TCAR para detección de quistes: 30% (IC95% 0.13-0.54. Conclusiones: Los trabajos publicados sobre enfermedades intersticiales se basan en la evaluación con cortes axiales de TCAR y la demostración de quistes es de suma importancia para diferenciar NIU de la Neumonía Intersticial No Específica (NINE. En este estudio, se evidencia que la utilización de MinIP con rotación del parénquima redefine 70% de los quistes como bronquioloectasias. Dado el rol cardinal de la TCAR en la evaluación de las intersticiopatías, es importante un estudio prospectivo de seguimiento con mayor número de casos que confirme si son los quistes reales y no los redefinidos como bronquioloectasias los que caracterizan a la NIU.Objective: To demonstrate that axial sections on high-resolution computed tomography (HRCT are insufficient for an accurate examination of diffuse interstitial lung diseases. To further show that minimum intensity projection (MinIP increases diagnosis specificity. Material and methods: Preliminary studies reporting small subpleural cysts were used to select 39 HRCT from 33 patients with confirmed collagen diseases and 6 patients with idiopathic interstitial disease. Patients were reexamined between october 2008 and june 2009. A 16-channel Philips Brillance multislice CT scanner was used. Sections were 1 mm thick de apices a bases. Patients were examined using the common technique, including the MinIP for axial, sagittal and coronal sections, with parenchymal rotation. Cystic areas were carefully examined. Spiral sections were also performed. Results: Of 20 HRCT depicting subpleural cysts with the conventional technique, 14 (70% were bronchiolectases. In 12 cases, images were all bronchiolectases; in the other 2, a prevalence of bronchiolectases and isolated cysts were seen. Real cysts could be confirmed in 6 cases (30%, all of which presented usual interstitial pneumonitis (UIP. The HRCT positive predictive value (PPV for cyst detection was 30% (95% CI 0.13-0.54. Conclusions: Interstitial diseases reports focus on performing axial sections on HRCT, and cyst detection is pivotal to differentiate UIP from NINE. This study reveals that the use of MinIP with parenchymal rotation redefines 70% of cysts as bronchiolectases. Given the key role of HRCT in the examination of interstitial diseases, it is important to carry out a prospective follow-up study with a larger number of cases, in order to confirm whether the UIP is characterized by real cysts or by cysts redefined as bronchiolectases.

  2. Epidermoid cysts of the posterior fossa and petroclival region. Treatment and outcome

    OpenAIRE

    Kwiek, SJ; Bazowski, P; Slusarczyk, W; Kukier, W; Luszawski, J; Wójcikiewicz, T; Wolwender, A; Namyslowski, G; Lisowska, G; Zymon-Zagórska, A

    2009-01-01

    Objectives: Surgical management of epidermoid cysts is still a challenge. One of the most important goals in epidermoids management is total tumor removal, but its tendency to adhere to cranial nerves and to the brain stem make technical problems in their complete removal. Approach to epidermal cysts of CPA and petroclival region is determined by tumor extension. Patients and methods: Since 1988 to 2004 among 226 operations of cerebellopontine angle (CPA) tumors (retrosigmoid approach ...

  3. Epidermoid cyst of the coronal sulcus mimicking penile cancer: a case report

    OpenAIRE

    Cormio, Luigi; Mancini, Vito; Sanguedolce, Francesca; Massenio, Paolo; Fucci, Livia; Bufo, Pantaleo; Traficante, Antonio; Carrieri, Giuseppe

    2014-01-01

    Introduction Epidermoid cysts represent common benign tumors occurring anywhere in the body but very rarely in the penis. Only a few cases of penile localization have been reported in the literature so far, most of them being congenital and/or idiopathic, usually presenting in children as slow-growing, solitary, well-delimited cystic lesions. Here, we describe the case of a patient with a penile epidermoid cyst presenting as an ulcerated lesion of the coronal sulcus, thus mimicking penile can...

  4. Quiste residual gigante: presentación de un caso / Residual cyst: a case presentation

    Scientific Electronic Library Online (English)

    Oscar, Rivero Pérez; Carlos, Albornoz López del Castillo; Isidro de Jesús, Nápoles González.

    2014-10-15

    Full Text Available Fundamento: un quiste es una estructura con tendencia a la forma redondeada, constituida por una pared externa de tejido conectivo fibroso, una pared interna formada por un tapiz epitelial. La cavidad quística contiene un material líquido o semilíquido de color cetrino que, cuando se infecta, se con [...] vierte en purulento y carmelitoso. El quiste residual puede haber sido anteriormente un quiste lateral o un quiste apical y al haberse extraído el diente, a partir de cuyo periodonto se forma el quiste, se queda en el tejido óseo sin haber sido extirpado. Objetivo: presentar un caso al cual se le diagnosticó y trató un quiste residual mandibular que abarcaba la hemiarcada izquierda, que permitió restablecer las funciones masticatorias y estética. Caso Clínico: paciente que fue atendido en la consulta de Cirugía Maxilofacial de la Facultad de Estomatología de Camagüey, con un aumento de volumen en la región lateral izquierda, con antecedentes de trauma anterior que le provocó fractura de mandíbula. Se describen las características clínicas de la enfermedad y el tratamiento quirúrgico realizado, se utilizó para el mismo los principios de la técnica de enucleación. Conclusiones: aunque se han reportados pocos casos en la literatura nacional y extranjera, estos han sido quistes de menor tamaño que incluyen uno o dos dientes, no existen reportes de quistes residuales que involucren toda la arcada o hemiarcada dentaria. Se obtuvieron resultados estéticos satisfactorios con la técnica quirúrgica empleada y no se presentaron complicaciones. Abstract in english Background: a cyst is a structure with a tendency to be rounded, made up of an external wall of fibrous connective tissue, an internal wall composed of epithelial tissue. The cystose cavity contains sallow liquid or semiliquid material that, when becomes infected, gets purulent and brown. A residual [...] cyst could have been previously a lateral cyst or an apical cyst and when the tooth is extracted from the periodontium, the cyst remains in the osseous tissue without being removed. Objective: to present a case diagnosed and treated for a mandibular residual cyst that extended over the left hemiarcade. It was possible to re-establish the masticatory and aesthetic functions. Clinical case: a patient who was treated in the Maxillofacial Surgery consultation of the Faculty of Stomatology of Camagüey. The patient presented a volume increase in the left lateral region and an antecedent of front trauma that caused fracture of the lower jaw. The clinical characteristics of the disease and the surgical treatment conducted are described. The principles of the enucleation technique were used for conducting the surgical treatment. Conclusions: in spite of the fact that few cases have been reported in the national and foreign literature, these have been smaller cysts that included one or two teeth. There are no reports of residual cysts that extend over all the dental arcade or hemiarcade. Satisfactory aesthetic results were obtained with the surgical technique applied and there were no complications.

  5. Quiste de ovario gigante. Presentación de un caso

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    Yarisdey Corrales Hernández

    2012-09-01

    Full Text Available Los quistes de ovario son tumoraciones frecuentes en las afecciones ginecológicas. Se presenta el   caso de una paciente de 46 años de edad, que acudió al Hospital General Universitario Dr. Gustavo Aldereguía Lima, de Cienfuegos, refiriendo dolor y aumento de volumen del abdomen de un año de evolución. Se realizaron examenes físico y ultrasonográfico, mediante los que se le diagnosticó una masa quística dependiente de ovario. Se practicó laparotomía y se resecó un quiste de ovario izquierdo. En su estudio anatomopatológico se comprobó el diagnóstico de cistoadenoma seroso del ovario.

  6. Testicular degeneration in Huntington disease.

    Science.gov (United States)

    Van Raamsdonk, Jeremy M; Murphy, Zoe; Selva, David M; Hamidizadeh, Reza; Pearson, Jacqueline; Petersén, Asa; Björkqvist, Maria; Muir, Cameron; Mackenzie, Ian R; Hammond, Geoffrey L; Vogl, A Wayne; Hayden, Michael R; Leavitt, Blair R

    2007-06-01

    Huntington disease (HD) is an adult onset, neurodegenerative disorder that results from CAG expansion in the HD gene. Recent work has demonstrated testicular degeneration in mouse models of HD and alterations in the hypothalamic-pituitary-gonadal (HPG) axis in HD patients. Here, we show that HD patients have specific testicular pathology with reduced numbers of germ cells and abnormal seminiferous tubule morphology. In the YAC128 mouse model, testicular degeneration develops prior to 12 months of age, but at 12 months, there is no evidence for decreased testosterone levels or loss of GnRH neurons in the hypothalamus. This suggests that testicular pathology results from a direct toxic effect of mutant huntingtin in the testis and is supported by the fact that huntingtin is highly expressed in the affected cell populations in the testis. Understanding the pathogenesis of HD in the testis may reveal common critical pathways which lead to degeneration in both the brain and testis. PMID:17433700

  7. What's New in Testicular Cancer Research and Treatment?

    Science.gov (United States)

    ... resources for testicular cancer What’s new in testicular cancer research and treatment? Important research into testicular cancer is ... Your Doctor After Treatment What`s New in Testicular Cancer Research? Other Resources and References Cancer Information Cancer Basics ...

  8. Diffusion tensor mode in imaging of intracranial epidermoid cysts: one step ahead of fractional anisotropy

    International Nuclear Information System (INIS)

    The signal characteristics of an epidermoid on T2-weighted imaging have been attributed to the presence of increased water content within the tumor. In this study, we explore the utility of diffusion tensor imaging (DTI) and diffusion tensor metrics (DTM) in knowing the microstructural anatomy of epidermoid cysts. DTI was performed in ten patients with epidermoid cysts. Directionally averaged mean diffusivity (Dav), exponential diffusion, and DTM-like fractional anisotropy (FA), diffusion tensor mode (mode), linear (CL), planar (CP), and spherical (CS) anisotropy were measured from the tumor as well as from the normal-looking white matter. Epidermoid cysts showed high FA. However, Dav and exponential diffusion values did not show any restriction of diffusion. Diffusion tensor mode values were near -1, and CP values were high within the tumor. This suggested preferential diffusion of water molecules along a two-dimensional geometry (plane) in epidermoid cysts, which could be attributed to the parallel-layered arrangement of keratin filaments and flakes within these tumors. Thus, advanced imaging modalities like DTI with DTM can provide information regarding the microstructural anatomy of the epidermoid cysts. (orig.)

  9. Testicular metastasis of prostatic cancer.

    Science.gov (United States)

    Smaali, Chemsedine; Gobet, Francoise; Dugardin, Fabrice; Pfister, Christian

    2010-02-01

    Secondary testicular tumors are rare, we report a case of a solitary testicular metastasis of prostate cancer in 58-year-old man treated using hormonal therapy associated with radiotherapy. Ultrasound is the imaging modality of choice, but metastasis might be difficult to differentiate from primary tumors. The diagnosis confirmed by histologic examination includes routine microscopic and immunohistochemical findings, and therefore systemic treatment was required. PMID:19913885

  10. Quiste dermoide del suelo de la boca Dermoid cyst in the mouth floor

    Directory of Open Access Journals (Sweden)

    Ayelén María Portelles Massó

    2010-12-01

    Full Text Available El quiste dermoide representa menos del 0,01 % de todos los quistes de la cavidad bucal. Su ubicación más frecuente es en suelo de boca. Se presenta el caso de una paciente femenina de 19 años de edad que hacía aproximadamente 7 años había notado un aumento de volumen debajo de la lengua, el cual le crecía paulatinamente y ya se apreciaba por fuera de la cara. Además, le ocasionaba molestias al hablar y al masticar. Se realizaron estudios complementarios y bajo anestesia general nasotraqueal. Se procedió a su exéresis quirúrgica mediante un abordaje intrabucal, donde se obtuvieron excelentes resultados estéticos y funcionales. El diagnóstico histopatológico se correspondió con un quiste dermoide de suelo de boca. La paciente no ha tenido recurrencia de la lesión transcurridos tres años de la operación. El quiste dermoide de suelo de boca se presenta como una tumoración benigna de la línea media. La exéresis intrabucal demuestra beneficios estéticos y funcionales.The Dermoid cyst account for the 0.01 % of all cysts of buccal cavity. Its more frequent location is in the mouth floor. This is the case of a female patient aged 19 who approximately 7 years noted an increase of volume under tongue growing gradually and noting outside face and the discomfort at to speak and to chew. Complementary studies were conducted and under general anesthesia a surgical exeresis was carried out by intrabuccal approach achieving excellent esthetic and functional results. Histopathologic diagnosis matched with a dermoid cyst of mouth floor. Patient has not lesion recurrence after three years after operation. We conclude that the Dermoid cyst of mouth floor appear as benign tumor of middle line. The intrabuccal exeresis demonstrates esthetic and functional benefits.

  11. Quiste dermoide del suelo de la boca / Dermoid cyst in the mouth floor

    Scientific Electronic Library Online (English)

    Ayelén María, Portelles Massó; Ailín Tamara, Torres Íñiguez.

    2010-12-01

    Full Text Available El quiste dermoide representa menos del 0,01 % de todos los quistes de la cavidad bucal. Su ubicación más frecuente es en suelo de boca. Se presenta el caso de una paciente femenina de 19 años de edad que hacía aproximadamente 7 años había notado un aumento de volumen debajo de la lengua, el cual le [...] crecía paulatinamente y ya se apreciaba por fuera de la cara. Además, le ocasionaba molestias al hablar y al masticar. Se realizaron estudios complementarios y bajo anestesia general nasotraqueal. Se procedió a su exéresis quirúrgica mediante un abordaje intrabucal, donde se obtuvieron excelentes resultados estéticos y funcionales. El diagnóstico histopatológico se correspondió con un quiste dermoide de suelo de boca. La paciente no ha tenido recurrencia de la lesión transcurridos tres años de la operación. El quiste dermoide de suelo de boca se presenta como una tumoración benigna de la línea media. La exéresis intrabucal demuestra beneficios estéticos y funcionales. Abstract in english The Dermoid cyst account for the 0.01 % of all cysts of buccal cavity. Its more frequent location is in the mouth floor. This is the case of a female patient aged 19 who approximately 7 years noted an increase of volume under tongue growing gradually and noting outside face and the discomfort at to [...] speak and to chew. Complementary studies were conducted and under general anesthesia a surgical exeresis was carried out by intrabuccal approach achieving excellent esthetic and functional results. Histopathologic diagnosis matched with a dermoid cyst of mouth floor. Patient has not lesion recurrence after three years after operation. We conclude that the Dermoid cyst of mouth floor appear as benign tumor of middle line. The intrabuccal exeresis demonstrates esthetic and functional benefits.

  12. Presentación clínica atípica de un quiste dentígero / Atypical clinical presentation of a dentigerous cyst

    Scientific Electronic Library Online (English)

    Denia, Morales Navarro; Guillermo, Sánchez Acuña; Liliana, Rodríguez Lay.

    2009-12-01

    Full Text Available Los quistes dentígeros suelen ser, en la mayor parte de los casos, un hallazgo casual; por lo general se descubren al investigar la no erupción de un diente permanente. Ocupan el segundo lugar en frecuencia de aparición en los maxilares después del quiste radicular. Cuando el seno maxilar es invadid [...] o por estos quistes los síntomas usualmente aparecen tardíos en el proceso. Estos pueden incluir dolor facial, parestesia como consecuencia de la presión sobre un nervio, dolor de cabeza, trismo, trastornos de la gustación y congestión nasal. Por lo infrecuente de la localización maxilar y la corta edad de la paciente nos vimos motivados a revisar lo más reciente de la bibliografía que aborda este tema y a presentar el caso clínico de una paciente femenina de 17 años que fue diagnosticada y tratada por presentar un quiste dentígero en dicha ubicación. Se enfatiza en la importancia del correcto diagnóstico y el establecimiento de una terapéutica concordante en cada caso. Abstract in english Dentigerous cysts are a casual finding in most of cases, in general discovered in investigation of a not eruption of permanent tooth. These occupy the second place in appearance frequency in maxillaries after radicular cyst. When maxillary sinus is invaded by these cysts, symptoms usually appear lat [...] e in the process. These could include facial pain, paresthesia as consequence of pressure on nerve, headache, trismus, taste disorders and nasal congestion. Due the infrequent of the maxillary location and the short age of patient we reviewed the more recent of bibliography on this subject and to present the clinical case of other female patient aged 17 diagnosed with and treated by dentigerous cyst in such location, emphasizing on the significance of a appropriate diagnosis and establishment of a therapy in accord in each case

  13. QUISTES NO NEOPLÁSICOS Y NEOPLÁSICOS DE OVARIO EN EDAD PEDIÁTRICA

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    José Raúl Sánchez Aguilar

    2006-01-01

    Full Text Available En Cuba los tumores y quistes de ovario en la infancia ocupan aproximadamente el 1% de todos los procesos tumorales, durante esta etapa de la vida, más del 50 % de estos tumores corresponden como quistes simples, teratomas benignos, y quistes foliculares, por lo que se realizó un estudio retrospectivo longitudinal en niños con incidencias de estos tumores en el Hospital Pediátrico ¿Eduardo Agramonte Piña¿, Camagüey, desde julio de 1973 a julio de 2004, con el objetivo de valorar la incidencia de estos tumores en niños. El universo y muestra lo constituyeron los 170 pacientes ingresados por dicha enfermedad. Se revisaron las historias clínicas de los enfermos. Se confeccionó un formulario que incluyó variables como. la edad, la forma de presentación, el lado más afecto, el histología, los complementarios realizados y las complicaciones, donde predominó el rango de edad entre los 11y15 años con 122 pacientes para un 71.8 %. Existió un aumento de la incidencia en el ovario derecho para un 71.8 %. Las lesiones de mayor prevalencia fueron los tumores quísticos benignos (teratomas quísticos con 107 de los pacientes, seguido de los quistes no neoplásicos (foliculares para un 12.4 %.El Rx simple de abdomen y el USG abdominal fueron los complementarios de mayor utilidad.

  14. Testicular microlithiasis and cryptorchidism a case report

    Directory of Open Access Journals (Sweden)

    Z. Miabi

    2006-01-01

    Full Text Available Testicular microlithiasis (TM is an uncommon condition with reported prevalence of 0.6% in patients referred for scrotal ultrasound. Testicular microlithiasis was first reported by Priebe and Garret in 1970 and defined as multiple tiny calcification throughout the testis. The condition appears as characterstic small nonshadowing hyperechoic stippling foci in testicular parenchyma. Several associations have been reported with testicular microlithiasis.Considrable accrued evidence points to an association between testicular microlithiasis, intra tubular germ cell neoplasia and testicular tumor. This topic is of considerable attention to researchers. We recommend annual ultrasonic follow up and patient education about self- examination and bio-humeral evaluation for ruling out concurrent tumors.

  15. Paraurethral cyst. A case report Quiste parauretral. Presentación de un caso

    Directory of Open Access Journals (Sweden)

    Emilio Vega Azcúe

    2011-03-01

    Full Text Available The paraurethral or Skene’s duct cyst, is a rare diagnostic entity in a newborn. It represents less than 0,5 % of congenital malformations of the urinary tract. All over the world it is reported an incidence of 1:2000 to 1:7000 in female births. In the newborn, the paraurethral cyst is caused by retention of secretions in the Skene's gland due to the obstruction of its ducts. Most of these cysts decrease in size during the first four to eight weeks, but they may cause symptoms of infection or urinary obstruction. They can also get formed from persistent embryonic remains of the mesonephric ducts (Wolffian duct, known as Gartner cysts and from the occlusion of unfused paramesonephric ducts (Müllerian. The case of a 25-day-old female, diagnosed with paraurethral cyst that underwent surgery and evolved successfully is presented.El quiste parauretral o de Skene, es una entidad de diagnóstico muy raro en el recién nacido, representa menos del 0,5 % de las malformaciones congénitas de las vías urinarias. Se reporta mundialmente una incidencia de 1:2000 a 1:7000 en los nacimientos femeninos. En la recién nacida, el quiste parauretral se origina por la retención de secreciones en la glándula de Skene, debido a la obstrucción de sus conductos. La mayoría de estos quistes disminuyen de tamaño durante las primeras cuatro a ocho semanas, pero pueden presentar síntomas de infección u obstrucción urinaria. También se pueden formar a partir de restos embrionarios persistentes de los conductos mesonéfricos (conductos de Wolf, llamados quistes de Gartner y de la oclusión de los conductos paramesonéfricos no fusionados (Müllerianos. Se presenta el caso de una paciente de 25 días de nacida, de sexo femenino, que se le diagnosticó un quiste parauretral y se le realizó tratamiento quirúrgico, del cual evolucionó de manera satisfactoria.

  16. Studies of testicular function after treatment for testicular tumor, 2

    International Nuclear Information System (INIS)

    It is important to preserve the testicular function of patients with testicular tumor after treatment. Testicular function after radiotherapy was endocrinologically investigated in the present study. 1. The levels of LH, FSH and testosterone in the blood were sequentially determined in patients with testicular tumor before, during and after radiotherapy. The blood levels of LH and FSH were high after therapy in the majority of the cases, but the levels decrease concomitantly with time. Blood levels of testosterone remained within the normal range. 2. The Gn-RH stimulation test after radiotherapy revealed an abnormally high response and a delayed normalization of the LH level within three years after therapy. However, these changes showed a tendancy to normalize in the patients after therapy for three years or longer. 3. The hCG stimulation test was performed after radiotherapy. The reaction rate of hCG was low in patients within three years on therapy, whereas it tended to return to normal pattern after three or more years on therapy. The results lead the conclusion as follows. 1. Spermatogenesis was damaged in the majority of testicular tumor after radiotherapy. However, it was recovered to a normal spermatogenesis after cessation of the therapy. 2. From the high basal level of serum LH and the response to Gn-RH and hCG stimulation tests after radiotherapy, it is presumed that the reserve function of Leydig cell was impaired by radiotherapy, although it returns to normal status after three years on the therapy. (author)

  17. Association between testicular microlithiasis, testicular cancer, cryptorchidism and history of ascending testis

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    Stamatiou Konstantinos

    2006-08-01

    Full Text Available OBJECTIVE: To prospectively determine the prevalence of testicular microlithiasis in symptomatic patients who were referred for scrotal ultrasound examination and to evaluate the possible association of testicular microlithiasis with testicular cancer and other conditions such as cryptorchidism or history of ascending testis. MATERIALS AND METHODS: 391 men who were referred to our institutions between July 2002 and May 2005 for any type of symptoms from the testicles, underwent physical and scrotal ultrasound examination. The presence of testicular microlithiasis, the number of lesions and the involvement of both testicles in relation to the symptoms as well as the coexistence of other lesions were studied. RESULTS: Eighteen (4.6% of 391 men enrolled into the study had testicular microlithiasis. Two out of the eighteen patients (11% had concomitant testicular cancer, which was confirmed by pathological evaluation of the orchidectomy specimen. One of the patients with testicular microlithiasis presented a rising in biochemical tumor markers (LDH, and HCG and underwent orchidectomy one year later. Five of the remaining 373 (1.3% patients without microlithiasis were diagnosed with testicular cancer. Thirty six men reported having a history of ascending testis, but none of them was found with testicular cancer. Two cases of testicular torsion in a cryptorchid position had testicular microlithiasis, but the orchidectomy specimen (after surgery was negative for testicular cancer. The correlation between testicular cancer and testicular microlithiasis found in our study was statistically significant (p < 0.05. CONCLUSION: There seems to be an association between testicular microlithiasis and testicular cancer.

  18. MANEJO LAPAROSCÓPICO DE QUISTES OVÁRICOS COMPLICADOS O PERSISTENTES DURANTE EL EMBARAZO

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    José Luis Troncoso J

    2009-01-01

    Full Text Available Antecedentes: El incremento en el hallazgo de quistes anexiales durante el embarazo sería el mayor uso de técnicas de reproducción asistida con hiperestimulación ovárica controlada. La complicación más frecuente sigue siendo la torsión anexial. Objetivo: Revisar el manejo de quistes anexiales complicados o persistentes, durante el embarazo, con resolución laparoscópica. Método: Revisión retrospectiva de 9 pacientes consecutivas, ingresadas al Departamento de Obstetricia y Ginecología Clínica Las Condes. Resultados: La edad gestacional de ingreso fue entre 5+5 y 27 semanas. Cinco casos fueron producto de fertilización asistida y cuatro espontáneos. Ocho (85,6% embarazadas, ingresaron por dolor abdominal agudo. Otro caso ingresó a cirugía electiva por quiste ovárico persistente. Los quistes tenían entre 6 y 13 cm. En 5 se realizó sólo destorsión ovárica, en 1 ooforectomía y en 1 quistectomía. Se realizó punción, destorsión y fijación a ligamento útero ovárico, bilateral, en la otra paciente. Se registró un caso de fiebre en el postoperatorio. El alta hospitalaria fue a las 48 horas en 6 (67%, a las 72 en 2 y a las 96 en 1. El estudio biópsico diferido en 3 pacientes demostró: 1 quiste seroso paratubario, 1 quiste luteínico parcialmente hemorrágico y 1 infarto anexial. Todos los embarazos evolucionaron normalmente. Conclusión: Nuestra experiencia confirma que en el embarazo la laparoscopía es una buena opción al requerir una cirugía por quiste anexial complicado o persistente.Background: Recent reviews show an increase in the finding of adnexal cysts during pregnancy. One reason could be the use of assisted reproductive techniques with controlled ovarian hyperstimulation. Objective: To review the experience in managing via laparoscopy complicated or persistent adnexal cysts during pregnancy. Method: Retrospective review of 9 consecutive patients, admitted at the Department of Obstetrics and Gynecology, Clínica Las Condes. Results: The gestational age was between 5+5 and 27 weeks. Five were the product of assisted fertilization and four spontaneous. Eight (85.6% pregnant women were admitted by emergency room because of acute abdominal pain and another one went through elective surgery for persistent ovarian cyst. Preoperative diagnosis of the 8 patients admitted by emergency: adnexal cyst complicated with torsion in 6 (1 adnexal infarction and 2 cases of acute abdomen. The cysts were between 6 and 13 cm. Type of surgery: in 5, only detorsión; ovarian oophorectomy in 1 and cystectomy in one. Puncture, detorsión and bilateral fixation of uterine ovarian ligament, in another patient. One case required conversion to laparotomy with adnexectomy. Postoperative fever was observed in one patient. Discharge was at 48 hrs in 6 (67% cases, at 72 hrs. in 2 and 96 hrs. in 1. Deferred biopsy performed in 3 patients showed: paratu-barian serous cyst, partially hemorrhagic luteal cyst, adnexal infarction. All pregnancies went on normally. Premature births are not reported. Conclusion: Our experience suggests that laparoscopic approach is a valid option for complicated or persistent adnexal cysts in pregnant women.

  19. Quistes foliculares en vacas posparto y su evolución con tratamiento de GnRH Y PGF2

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    Leonardo Duque Muñoz

    2011-01-01

    Full Text Available Introduccion. Se analizaron retrospectivamente datos reproductivos en un lapso de tiempo cercano a 18 meses, en cinco hatos lecheros del municipio de San Pedro de los Milagros (Ant, con una poblacion de 950 vacas. Objetivo. Analizar la evolucion del tratamiento a vacas con quistes foliculares. Materiales y metodos. Las vacas fueron tratadas con GnRH a doble dosis y a los 14 dias PGF2¿¿. Si persistio el quiste se repitio dos veces mas el tratamiento. Analisis estadistico. Los datos fueron analizados utilizando el software SAS con un Anova, considerando como significativos todos los datos con un p<0,05. Resultados. Se encontro una frecuencia de presentacion de quistes en posparto tardio de 8,9 %; el porcentaje de vacas que resolvieron el problema al primer tratamiento fue de 74,1 %, con un promedio de 87,3 dias de diagnostico posparto, al segundo 10,5 % con 141,8 dias promedio y 3,5 % al tercero con 189,3 dias al diagnostico; el porcentaje de vacas descartadas fue de 11,8 %. Conclusiones. Este analisis retrospectivo de cinco hatos lecheros, demuestra que se presentan con relativa frecuencia quistes foliculares en el posparto tardio, pero se pueden solucionar efectivamente si se diagnostican en los primeros 90 dias, ademas el tratamiento realizado despues de detectado el quiste folicular entre 80-90 dias posparto, es efectivo para resolver el 74,12% de los casos, con una tasa de prenez del 70,5%.

  20. 21 CFR 876.3750 - Testicular prosthesis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Testicular prosthesis. 876.3750 Section 876.3750...) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Prosthetic Devices § 876.3750 Testicular prosthesis. (a) Identification. A testicular prosthesis is an implanted device that consists of a solid or gel-filled...

  1. Seminal profile of subjects with testicular microlithiasis and testicular calcifications.

    Science.gov (United States)

    Mazzilli, Fernando; Delfino, Michele; Imbrogno, Norina; Elia, Jlenia; Spinosa, Vincenzo; Di Nardo, Raffaella

    2005-07-01

    Two hundred eighty-one male partners of infertile couples were studied to determine the prevalence of subjects with testicular microlithiasis (TM) or testicular calcifications (TC) to define the seminal profile of this population and to initiate a longitudinal study to evaluate the significance of TM and TC as predictive markers of cancer. The prevalence found was 4.6% and 3.9%, respectively, which is sufficiently high to merit careful research attention, although TM and TC do not appear to be pathogenic factors of dyspermia. PMID:16009194

  2. Natural flavonoid derivatives as oral human epidermoid carcinoma cell inhibitors.

    Science.gov (United States)

    Gunda, Shravan Kumar; Kongaleti, Sofia Florence; Shaik, Mahmood

    2015-01-01

    Natural flavonoid derivatives against cancer for selective KB cell lines (oral human epidermoid carcinoma) are analysed to determine the relationship between biological activities and structural properties of these molecules. Molecular alignment was performed for 88 natural flavonoid derivatives; out of these 88 molecules, 69 molecules were taken into training set and rest of the 19 molecules were used in test set prediction. We describe our elucidation of their structure activity relation (SAR) using three-dimensional quantitative structure activity relationship (3D-QSAR) models. A predictive comparative molecular field analysis (CoMFA) model of q² = 0.888 and r² = 0.940 was obtained and a comparative molecular similarity indices analysis (CoMSIA) model q² = 0.778 and r² = 0.971 was used to describe the non-linearly combined affinity of each functional group in the inhibitors. The contour maps obtained from 3D-QSAR studies were evaluated for the activity trends of the molecules analysed. PMID:25869317

  3. The diagnosis of epidermoids of the cerebellopontine angle with balanced fast field echo

    International Nuclear Information System (INIS)

    Objective: To assess the clinical value of balanced fast field echo (B-FFE) in the detection for epidermoids of the cerebellopontine angle. Methods: The findings of conventional magnetic resonance imaging and B-FFE imaging in 8 cases with epidermoid of the cerebellopontine angle were retrospectively analyzed. The diagnosis was proved by operation and pathology. Results: In seven of the eight cases, the epidermoids exhibited signal intensities relatively similar to CFS on conventional T1- and T2- weighted MR images. The remaining case showed iso intensity on either T1- or T2- weighted MR images, which was almost neglected. All of the eight cases showed heterogeneous signal characteristics on B-FFE, which were quite different from the signal of CFS. Meanwhile, B-FFE also produced clearly the tissue contrast of trigeminus embedded in the epidermoids of the cerebellopontine angle. Conclusion: B-FFE is an efficient and fast technique for diagnosing the epidermoid of the cerebellopontine angle. It can also provide precise preoperative information about the trigeminus encasement. (author)

  4. Intracranial germinoma in the pineal region arising after subtotal resection of epidermoid cyst: case report.

    Science.gov (United States)

    Walker, Amanda J; Huynh-Le, Minh-Phuong; Nauen, David; Malayeri, Ashkan A; Jallo, George; Terezakis, Stephanie A

    2014-05-01

    We present an unusual case of a germinoma of the pineal region arising adjacent to an epidermoid cyst in a 16-year-old male. Initial imaging findings were classic for epidermoid cyst. The patient underwent two partial resections at an outside institution, each specimen demonstrating pure epidermoid cyst. Follow-up imaging over a period of 24 months showed an area of progressive contrast enhancement adjacent to the initial lesion, suggesting the development of a neoplasm. Given the area of contrast enhancement in addition to worsening headaches and visual changes, he underwent a third and final resection at our institution. Pathology revealed a mixed germ cell tumor with prominent germinoma component in addition to a well-differentiated epidermoid cyst. Details of his imaging and pathologic findings are presented, and possible explanations for these findings are explored, the most likely of which is lack of complete resection at the onset failed to identify the whole of the neoplasm. We conclude that pediatric epidermoid cysts of the pineal region should always receive close follow-up, particularly when total resection is not performed. PMID:24221216

  5. Comportamiento del quiste branquial en pacientes del Hospital General Docente "Ciro Redondo García", Artemisa, 1993-2009

    Directory of Open Access Journals (Sweden)

    Juan Carlos Quintana Díaz

    2012-03-01

    Full Text Available El quiste branquial de origen congénito que aparece en la región lateral del cuello es, con frecuencia, motivo de consulta. Se tuvo como objetivo determinar el comportamiento de los quistes branquiales en el Hospital "Ciro Redondo García", de Artemisa en el periodo de 1993 al 2009. Se realizó un estudio descriptivo transversal de los quistes branquiales diagnosticados en pacientes intervenidos quirúrgicamente en el Servicio de Cirugía Maxilofacial. Se estudiaron la edad, el sexo, el color de la piel, el lado del cuello afectado, el resultado histopatológico y los medios auxiliares empleados. Se encontraron 12 quistes branquiales que afectaron el 50 % de ambos sexos, un 75 % a pacientes entre 15 y 30 años y un 75 % de la piel blanca, un 66,7 % afectó el lado derecho del cuello y en un 100 % de los casos se utilizó la biopsia y el ultrasonido como medios auxiliares para su diagnóstico. Se encontró epitelio escamoso estratificado en un 100 % de los quistes y en un 91,6 % el tejido linfoide. No se encontró predilección por el sexo, la mayoría de los pacientes eran menores de 30 años, de piel blanca y presentaban los quistes en el lado derecho del cuello. En todos los pacientes se empleó la biopsia y el ultrasonido como medios auxiliares de diagnóstico. El epitelio escamoso estratificado y el tejido linfoide fueron los hallazgos histopatológicos más relevantes.

  6. Quiste renal gigante. Presentación de un caso / Giant renal cyst. Presentation of a case

    Scientific Electronic Library Online (English)

    Teresa, Suárez Díaz; Yuniel, Arocha Molina; Ariel, Jordán Alonso; Roberto, Ruiz Reyes; Adianez, Jiménez Álvarez.

    2013-08-01

    Full Text Available En el riñón frecuentemente se desarrollan quistes. Dentro de la diversidad de quistes renales, el simple puede presentarse dentro del riñón o en la superficie de este pudiendo, ser único o múltiple, unilateral o bilateral y más frecuente en el izquierdo. Generalmente se manifiestan asintomático y pu [...] eden alcanzar gran tamaño, denominándose quistes gigantes. Se presenta un paciente de 66 años que ingresa por dolor lumbar hace un año, que empeora a pesar del tratamiento médico para una presunta sacrolumbalgia. En el abdomen se aprecia marcado aumento de volumen, sobre todo hacia el hemiabdomen superior y se palpa gran masa tumoral que ocupa la totalidad del hemiabdomen superior, renitente y no dolorosa. Se realizó tomografía axial computarizada de abdomen, apreciándose imagen hipodensa multitabicada que ocupa todo el hemiabdomen izquierdo con desplazamiento de asas, riñón izquierdo y músculo psoas. Se concluye como quiste gigante multitabicado de riñón izquierdo. Se realizó laparotomía paramediana izquierda supra e infraumbilical y se detecta gran quiste renal del polo superior del riñón izquierdo que sobrepasa la línea media desplazando la arteria aorta a la derecha de la columna vertebral. Se realizó nefrectomía izquierda. Es raro, que un quiste renal simple gigante, sobrepase la línea media y tenga compresión de tantos órganos intraabdominales; este es un hecho poco descrito en la literatura médica. El examen físico superficial y limitado al órgano que produce los síntomas que motivan la consulta, limita el diagnóstico precoz de muchas enfermedades como se demuestra en este paciente. Este es uno de los errores más frecuentes que se aprecian al aplicar el método clínico. Abstract in english Frequently, cysts develop in the kidney. Among the diversity of renal cysts, the simple one could be located inside the kidney or in its surface and may be single or multiple, unilateral or bilateral, and more frequent in the left kidney. Generally they are asymptomatic and can reach a great size, c [...] alled giant cysts. We present a patient aged 66 years, entering the hospital with lumbar pain of one year that gets worse despite the medical treatment for a presumed sacrolumbal pain. It was found a remarked increase of the abdomen volume, mainly in the direction of the upper hemiabdomen and it feels a big tumoral mass filling the totality of the upper abdomen, renitent and no painful. An abdominal computer tomography was carried out, finding a multi partitioned hypodense image filling all the left hemiabdomen with displacement of loops, left kidney and psoas muscle. We arrived to the conclusion that it was a giant multi partitioned cyst of the left kidney. A left paramedian supra and infra umbilical laparotomy was carried out finding a renal cyst of the upper pole of the left kidney surpassing media line and displacing aortal artery to the right of the spinal column. A left nephrectomy was carried out. It is rare a simple renal giant cyst surpassing the media line and compressing so many intra abdominal organs; this is a fact scarcely described in the medical literature. The surface physical examination restricted to the organ producing the symptoms that motivate the consultation, interferes the precocious diagnosis of many diseases as it is shown in this patient. This is one of the most frequent mistakes committed when applying the clinical method.

  7. Hypothalamic-pituitary-testicular system following testicular X-irradiation

    International Nuclear Information System (INIS)

    Testes of adult, male rats were exposed to a total dose of 1500 R of X-irradiation. Testicular weight decreased from day 8 after X-ray treatment. This decrease was, however, precded by an increment of the testis weight on day 4 following treatment. X-ray treatment of testes was associated with significant increase in serum FSH. Testicular irradiation had, however, no effect on ventral prostate and seminal vesicles weights. Serum testosterone increased only on day 1, 2 and 4 after irradiation, while serum LH levels tended to increase from day 8 post-irradiation. These changes were not significant, however, when compared with non-irradiated controls. At 7, 13 and 20 days following 1500 R of bilateral, testicular X-irradiation, the hypothalamic-pituitary unit was still capable of responding to exogenous gonadotrophin releasing factor. Serum FSH may in male rats be regulated at least partly by circulating steroids of testicular origin and partly by an unknown factor of non-interstitial cell nature. (author)

  8. Pancreatitis aguda como presentación de un quiste del conducto biliar en el adulto: reporte de caso

    OpenAIRE

    Enriquez Domínguez, Lenin; Díaz Rosales, Juna de Dios; Cabrera Hinojosa, Enrique; Gutiérrez Ramírez, Pedro; Aguayo Muñoz, Baltazar

    2010-01-01

    Paciente adulta se presentó en la sala de urgencias con un cuadro de pancreatitis aguda como complicación de un quiste del conducto biliar colédoco tipo IV, el cual fue diagnosticado por ultrasonograma abdominal durante su estancia intrahospitalaria. El diagnóstico de quiste de colédoco es más difícil en la edad adulta ya que los pacientes raramente se presentan con la triada clásica de dolor abdominal, masa palpable e ictericia, presentándose principalmente con alguna manifestación de ví...

  9. Association between testicular microlithiasis, testicular cancer, cryptorchidism and history of ascending testis

    Scientific Electronic Library Online (English)

    Stamatiou, Konstantinos; Alevizos, Alevizos; Mariolis, Anargiros; Mihas, Constantinos; Halazonitis, Athanase; Bovis, Konstantinos; Eleftherios, Michail; Sofras, Fragiskos.

    2006-08-01

    Full Text Available OBJECTIVE: To prospectively determine the prevalence of testicular microlithiasis in symptomatic patients who were referred for scrotal ultrasound examination and to evaluate the possible association of testicular microlithiasis with testicular cancer and other conditions such as cryptorchidism or h [...] istory of ascending testis. MATERIALS AND METHODS: 391 men who were referred to our institutions between July 2002 and May 2005 for any type of symptoms from the testicles, underwent physical and scrotal ultrasound examination. The presence of testicular microlithiasis, the number of lesions and the involvement of both testicles in relation to the symptoms as well as the coexistence of other lesions were studied. RESULTS: Eighteen (4.6%) of 391 men enrolled into the study had testicular microlithiasis. Two out of the eighteen patients (11%) had concomitant testicular cancer, which was confirmed by pathological evaluation of the orchidectomy specimen. One of the patients with testicular microlithiasis presented a rising in biochemical tumor markers (LDH, and HCG) and underwent orchidectomy one year later. Five of the remaining 373 (1.3%) patients without microlithiasis were diagnosed with testicular cancer. Thirty six men reported having a history of ascending testis, but none of them was found with testicular cancer. Two cases of testicular torsion in a cryptorchid position had testicular microlithiasis, but the orchidectomy specimen (after surgery) was negative for testicular cancer. The correlation between testicular cancer and testicular microlithiasis found in our study was statistically significant (p

  10. Primary intradural sacral epidermoid in a nondysraphic spine: Case report and review of literature

    Science.gov (United States)

    Sivaraju, Laxminadh; Thakar, Sumit; Ghosal, Nandita; Hegde, Alangar S

    2016-01-01

    The occurrence of epidermoids within the spinal canal is uncommon. Most of the reported spinal epidermoids (SEs) have been described in the thoracic or lumbar regions. They occur either following trauma or in the setting of coexistent spinal dysraphism. The authors describe an unusual case of a 28-year-old lady who presented with long-standing back pain and urinary incontinence. Magnetic resonance imaging (MRI) of her spine demonstrated a sacral SE without any coexistent spinal dysraphism. The diagnosis of an epidermoid was confirmed by histopathological examination following laminectomy and excision. To the authors’ best knowledge, this is the third case of a sacral SE occurring in a non-dysraphic spine. The case is discussed in the light of a relevant literature review.

  11. Lymphoepithelial cyst in the palatoglossus arch Quiste linfoepitelial en el arco palatogloso

    Directory of Open Access Journals (Sweden)

    Evanice Maria Marçal Vieira

    2012-12-01

    Full Text Available The objective of this study was to describe a case of a lymphoepithelial cyst in the palatoglossus arch. A 16-years-old black man said that he was observed a lesion in his mouth. On the physical exam, a pedicled, consistent, smooth surface 1.5 x 1 cm lesion, similar in color to the adjacent mucosa, was found. The lesion was surgically removed and the microscopic exam showed mucosal fragments with pedicled lesion; the cystic cavity sometimes lined with pseudostratified cylindrical epithelium and others with stratified squamous flat interface of the epithelium. Around the cyst, a well-delimited mass of lymphoid tissue, presenting lymphoid follicles, was also seen. Lymphoepithelial cyst has clinical characteristics similar to those of others lesions that occur in the oral cavity. The diagnosis should be based on conservative biopsy, with total removal of lesion.El objetivo de este estudio fue describir un caso clínico de quiste linfoepitelial en el arco palatoglosso. Paciente de 16 años de edad, sexo masculino, raza negra, que durante la anamnesis relató que observó una lesión en la boca. Al examen físico se observó una lesión pediculada, de consistencia firme, superficie lisa, de 1,5 x 1,0 cm de tamaño, con color similar al de la mucosa adyacente. La lesión fue removida quirúrgicamente y el examen microscópico mostró fragmentos de mucosa con lesión pediculada, la cavidad del quiste a veces revestida por epitelio cilíndrico pseudoestratificado y otras veces por la interfase plana del epitelio escamosa estratificado. Alrededor del quiste, una masa bien delimitada de tejido linfoide con presencia de folículos linfoides. El quiste linfoepitelial tiene las mismas características clínicas de otras lesiones que ocurren en la cavidad oral, el diagnóstico debe ser realizado por biopsia, de manera conservadora, con eliminación total de la lesión.

  12. Quiste pilonidal gigante en un anciano Giant pilonidal cyst in an elderly man

    OpenAIRE

    Héctor Bell Santos; Marcos Antonio Santos Danger

    2011-01-01

    Se describe el caso clínico de un anciano con quiste pilonidal gigante, cuya información primaria al respecto se obtuvo de la labor de terreno realizada por su médico de familia y anotada en la historia clínica individual del paciente, el cual fue intervenido quirúrgicamente y con éxito en el Servicio de Coloproctología del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba en enero de 2010, cuando se efectuó la exéresis total del tumor sin lesionar el recto.A case re...

  13. Quiste dermoide verdadero en piso de boca / True dermoid cyst in the floor of the mouth

    Scientific Electronic Library Online (English)

    Daniel, Antunes Freitas; Jessica, Lozano Perez; Luis, Fang Mercado; Antonio, Díaz Caballero.

    2013-09-01

    Full Text Available Los quistes dermoides son lesiones benignas de origen embrionario, con una incidencia del 0,01 % de todos los quistes de la cavidad bucal. No presenta predicción por sexo y alrededor del 60 % de los casos se desarrollan entre los 15 y 35 años de edad. El conocimiento de los hallazgos clínicos de est [...] e tipo lesiones es vital para un diagnóstico definitivo, sin embargo, este siempre debe ser corroborado mediante exámenes histopatológicos, especialmente, al realizar un diagnóstico diferencial entre los diferentes tipos de quiste dermoides u otras alteraciones a nivel oral con manifestaciones clínicas similares. El propósito de esta presentación reportar un caso clínico para ampliar conocimientos sobre el diagnóstico y tratamiento de este tipo de lesión debido a su infrecuencia en cavidad oral. La ubicación inusual de estos quistes en cavidad oral hace que, aún con una buena valoración clínica e imaginológica, el diagnóstico prequirúrgico preciso sea difícil. Es por esto que el tratamiento quirúrgico no sólo evita el riesgo de una complicación infecciosa y eventual malignización sino que permite obtener un diagnóstico definitivo mediante estudios histopatológicos. Abstract in english Dermoid cysts are benign lesions of embryonic origin, with an incidence of 0.01 % of all cysts in the oral cavity. There is no prediction by sex and about 60 % of cases develop at the age of 15 to 35 years old. Knowledge of the clinical findings of such injuries is vital for a definitive diagnosis; [...] however, this should always be confirmed by histopathological examination, especially when making a differential diagnosis between different types of dermoid cyst or other pathologies with similar clinical manifestations. The purpose of this article is to expand knowledge about the diagnosis and treatment of this type of injury because of it is not frequent in the oral cavity. The unusual location of these cysts in the oral cavity makes hard the precise preoperative diagnosis, even with good clinical and radio-graphical assessment. The surgical treatment not only prevents the risk of infectious complications and possible malignancy but also, allows obtaining a definitive diagnosis by a histopathological study.

  14. Leech therapy for epidermoid cysts and review of the literature

    Directory of Open Access Journals (Sweden)

    Abbas Rasi

    2014-01-01

    Full Text Available Hirudo medicinalis sucks blood directly through the external mammalian skin. We recently observed a healthy 64-year-old Iranian man, who presented with numerous asymptomatic multilobular oval-to-round well-defined 0.5 to 1.5 cm cystic lesions with central umbilication (central black eschar over the upper portion of his chest. We made the diagnosis of epidermoid cyst, giant comedone and leech bite on the basis of the constellation of clinical features. The patient was treated with oral ciprofloxacin at a dose of 2 g daily, and 2% topical erythromycin solution. Despite improvement, the evidence of cystic lesions persisted. There was no history of similar lesions in any other family member. There was no history of trauma. The patient was not using any topical or systemic medication. Two weeks before his visit, he had a history of leech therapy under the supervision of a general practitioner. His medical history was significant for leech therapy of the lesions, five days previously. He was followed up for another two weeks and after disappearance of the inflammation, with the patient under local anesthesia, the well-circumscribed mass was completely evacuated with a sharp curette and comedone extractor. The patient was subsequently lost to follow-up. Conclusion: Considering the efficacy of leeches, it would be favorable to breed a germ-free leech. In Iran, the use of the leeches in surgery, in recent years, has been infrequent. It appears that the positive effects of this ancient remedy may now be explained through scientific methods, promising potentially even more uses of this admirable creature in medicine.

  15. Drugs Approved for Testicular Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for testicular cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  16. Epidermoid Cyst in the Floor of Mouth with Sub Mental Component

    OpenAIRE

    Tandon, P.N.; Gupta, D S

    2011-01-01

    Epidermoid cysts in the oral cavity are very rare. They are slow and progressive in growth. Although congenital, they are diagnosed in second or third decayed of life. Epidermoid cyst in the floor of mouth is painless, doughy in consistency, fluctuant lesion and causes no symptoms until they are large enough to interfere with chewing or speech. In this article a 23 years old girl presented with lesion almost filling the oral cavity as well as sub mental component giving appearance of double c...

  17. Quiste dermoide en la cola de la ceja / Dermoid cyst in the eyebrow tail

    Scientific Electronic Library Online (English)

    Lázara Kenia, Ramírez García; Datia Liset, Ortiz Ramos; Clara Gisela, Gómez Cabrera; Lázaro, Vigoa Aranguren; Irene, Rojas Rondón; Franklyn Alain, Abreu Perdomo.

    2014-03-01

    Full Text Available El quiste dermoide es un tipo de coristoma que corresponde a una anomalía congénita del desarrollo. Se presenta una transicional de dos años. Desde su nacimiento, la mamá notó un aumento de volumen a nivel de la cola de la ceja del ojo derecho, de bordes delimitados, blanda, movible, reborde orbitar [...] io libre, sin cambios de coloración, con un crecimiento acelerado clínico y ultrasonográfico en meses. Se decidió exéresis y biopsia para estudio anatomopatológico. Los resultados finales mostraron confirmación del diagnóstico de quiste dermoide en la cola de la ceja. La evolución posoperatoria fue satisfactoria sin recidiva de la lesión. Abstract in english The dermoid cyst is a type of choristoma resulting from congenital development anomaly. A 2-year transitional dermoid cyst from birth was discovered by the mother when she noticed increased volume at the tail of the right eyebrow, defined edges, soft, movable, free orbital rim, no color changes with [...] rapid clinical and ultrasonographic growth in months. It was decided to perform excision and biopsy for the pathological study. The final results showed confirmation of the diagnosis of dermoid cyst in tail of the eyebrow. The postoperative course was satisfactory without recurrent injure.

  18. Fibroma ameloblástico versus quiste folicular hiperplásico / Ameloblastic fibroma versus hyperplastic follicular cyst

    Scientific Electronic Library Online (English)

    J., Azúa-Romeo; E., Saura Fillat; T., Usón Bouthelier; M., Tovar Lázaro; J., Azúa Blanco.

    2004-06-01

    Full Text Available Resumen: El fibroma ameloblástico (FA) es un tumor odontogénico mixto, compuesto por tejido mesenquimal y epitelio odontogénico, representando el 2% de los tumores odontogénicos, mientras que el quiste dentígero o folicular (QF), el segundo quiste odontogénico en frecuencia, está compuesto exclusiva [...] mente por tejido conjuntivo laxo (mesénquima), si bien, el saco fibroso puede contener restos de epitelio odontogénico incluidos, dando lugar a una imagen histológica muy similar. La importancia de esta diferenciación radica en el tratamiento, que es ligeramente más agresivo en el FA y en el comportamiento biológico, ya que el FA puede derivar en un sarcoma ameloblástico, y el QF puede evolucionar hacia ameloblastoma y más raramente carcinoma mucoepidermoide. Abstract in english Abstract: Ameloblastic fibroma (AF) is a mixed odontogenic tumor composed of mesenchymal tissue and odontogenic epithelium, accounting for 2% of all odontogenic tumors, while dentigerous or follicular cyst (FQ), second odontogenic cyst in frequency, is formed exclusivelly by soft conective tissue (m [...] esenchyme). Nevertheless, hiperplastic fibrous sac may contain rests of odontogenic epithelium, showing a similar histologic pattern. The importance of an adequate differentiation lies in the treatment, which is slightly aggresive for AF, and regarding the biological behaviour of both lesions, since AF might become in an ameloblastic sarcoma, while over an FQ could develope an ameloblastoma or even a mucoepidermoid carcinoma.

  19. Giant Ovarian Cyst. A Case Report Quiste de ovario gigante. Presentación de un caso

    Directory of Open Access Journals (Sweden)

    Yarisdey Corrales Hernández

    2012-09-01

    Full Text Available Ovarian cysts are common tumors among gynecological conditions. The case of a 46 years old woman who arrived at the Dr. Gustavo Aldereguía Lima General University Hospital in Cienfuegos, because of pain and swelling of the abdomen of a year of evolution is presented. The physical examination and ultrasound were performed and the patient was diagnosed with an ovarian dependant cystic mass. Laparotomy was performed and the left ovarian cyst was resected. In pathological and anatomical studies the diagnosis of an ovarian serous cystadenoma was confirmed.Los quistes de ovario son tumoraciones frecuentes en las afecciones ginecológicas. Se presenta el   caso de una paciente de 46 años de edad, que acudió al Hospital General Universitario Dr. Gustavo Aldereguía Lima, de Cienfuegos, refiriendo dolor y aumento de volumen del abdomen de un año de evolución. Se realizaron examenes físico y ultrasonográfico, mediante los que se le diagnosticó una masa quística dependiente de ovario. Se practicó laparotomía y se resecó un quiste de ovario izquierdo. En su estudio anatomopatológico se comprobó el diagnóstico de cistoadenoma seroso del ovario.

  20. Infección por Echinococcus granulosus (quiste hidatídico: Reporte de un caso

    Directory of Open Access Journals (Sweden)

    Ida González Núñez

    2001-12-01

    Full Text Available Se reportó la infección larvaria por Echinococcus granulosus (quiste hidatídico en una niña de 10 años procedente de Ucrania. Las manifestaciones clínicas fueron ligeras pues solo se quejaban de dolor abdominal frecuentemente. El diagnóstico se realizó por ultrasonido y la detección inmunoenzimática de anticuerpos contra Echinococcus (ELISA con títulos de 1/800. Se le puso tratamiento con varios ciclos de albendazol y tuvo una evolución favorable con reducción del tamaño del quiste.Larval Echinococcus granulosus infection (hydatid cyst was reported in a 10 years-old Ukranian girl. The clinical manifestations were slight since she only complained of frequent abdominal pain. The diagnosis was made by ultrasound and immunoenzymatic detection of antibodies to Echinococcus (ELISA. Antibody titers were 1/800. She was repeatedly treated with albendazol, and she managed to recover while the size of her cyst was reduced.

  1. Epidermoid carcinoma of the skin mimicking breast cancer Carcinoma epidermoide na pele da mama simulando câncer de mama

    OpenAIRE

    Baltasar Melo Neto; Giuliano da Paz Oliveira; Sabas Carlos Vieira; Livio Rodrigues Leal; José Andrade de Carvalho Melo Junior; Cyro Franklin Vieira

    2013-01-01

    Nonmelanoma skin cancer is the most frequent cancer in the world. Squamous cell cancer often occurs in sun-exposed areas, such as the head and neck. When it involves the breast and ulce-rates, invading the glandular parenchyma, it may mimic breast cancer. Confirmation by means of histopathological examination, combined with clinical examination, is a critical instrument for the accuracy of the diagnosis. We report a case of an epidermoid carcinoma located on the breast skin, initially diagnos...

  2. Primary testicular NHL mimicking testicular carcinoma on FDG PET

    International Nuclear Information System (INIS)

    A 57-year-old man presented with left testicular swelling. An ultrasound showed a 6cm mass in the left testis and 3 small nodules in the right testis. A CT scan showed left para-aortic nodes and no nodal disease elsewhere. An excisional biopsy of the left testis was followed by an FDG PET scan. A right orchidectomy was then performed. Histology showed diffuse large B cell lymphoma involving both testes and the left spermatic cord. Testicular lymphoma and carcinoma cannot be distinguished using FDG-PET thus emphasizing the principle that FDG-PET should be used as a tool for staging, not for primary diagnosis and that the nature of the pathological condition causing FDG uptake has to be confirmed with biopsy/histology Copyright (2006) Blackwell Publishing Asia Pty Ltd

  3. Radiotherapy for Epidermoid Carcinoma of the Anus: Thirty Years' Experience

    International Nuclear Information System (INIS)

    Purpose: To evaluate the factors associated with disease control and morbidity after radiotherapy for anal carcinoma. Methods and Materials: Between 1975 and 2005, 194 patients with localized epidermoid anal carcinoma underwent radiotherapy. Treatment evolved from radiotherapy with or without surgery, to preoperative chemoradiotherapy, to definitive chemoradiotherapy (CRT). The radiotherapy techniques also evolved. Results: With a median follow-up of 61 months, 57 patients had persistence or recurrence, 9 of whom were successfully salvaged, resulting in 146 (75%) ultimately free of disease (UNED). Univariate analysis for UNED survival showed a strong association with the T and N stage (5-year UNED rate, 88.5% ± 3.4% for those with Stage T1-T2N0; 70.1% ± 4.2% for Stage T3N0; and 52.7% ± 6.6% for Stage III; p > .001) and mobility on palpation (5-year UNED rate, 89.2% ± 4.6% for those with mobile tumors vs. 59.3% ± 6.1% for those with tethered/fixed tumor; p > .001). No association was found with gender, age, preoperative vs. definitive CRT, or human immunodeficiency virus status. The 20 human immunodeficiency virus+ patients all received CRT. The radiotherapy factors associated with Grade 3 or greater late morbidity included anorectal morbidity with tumor dose (29% with a dose ≥55 Gy vs. 9% otherwise), small bowel injury with technique (9% with anteroposterior-posteroanterior supine vs. 0.7% with multiple fields prone), and bone injury with femoral head dose (9% with a dose of ≥44 Gy vs. 0.7% otherwise). Of the 194 patients, 56 had 68 additional malignancies, mainly either antedating the anal cancer or outside the radiation fields. Conclusion: Our results have confirmed that CRT is an effective approach. Patients with human immunodeficiency virus can be treated with CRT. Tumor mobility significantly predicts the outcome; the implications for management are discussed. We also discuss the treatment planning implications of the late morbidity findings. The substantial incidence of additional malignancies underscores the importance of full oncologic screening during follow-up.

  4. Genetics Home Reference: 46,XX testicular disorder of sex development

    Science.gov (United States)

    ... disorder catalog Conditions > 46,XX testicular disorder of sex development On this page: Description Genetic changes Inheritance ... 2008 What is 46,XX testicular disorder of sex development? 46,XX testicular disorder of sex development ...

  5. Magnetic resonance imaging and quantitative analysis of contents of epidermoid and dermoid cysts

    International Nuclear Information System (INIS)

    The intracapsular cholesterol protein, and calcium contents of epidermoid and dermoid cysts from seven patients were compared with the signal intensities on T1-weighted spin-echo magnetic resonance (MR) images. All specimens had a paste-like consistency when resected. Epidermoid and dermoid cysts demonstrated a wide range of cholesterol and calcium contents, and epidermoid cysts were not always rich in cholesterol. Five patients had cysts with lower signal intensity than white matter, which contained more than 18.3 mg/g wet weight of protein. One of these patients had the highest cholesterol content of all seven patients (22.25 mg/g wet weight) and another had the highest calcium content (0.75 mg/g wet weight). Two patients had cysts with higher signal intensity than white matter, with protein contents of lower than 4.3 mg/g wet weight. High protein content (>18.3 mg/g wet weight) may decrease signal intensity on T1-weighted MR images, while low protein content (<4.3 mg/g wet weight) may increase signal intensity in epidermoid and dermoid cysts with high viscosity (paste-like consistency) contents. (author)

  6. Bilateral hypertrophic olivary degeneration following surgical resection of a posterior fossa epidermoid cyst

    OpenAIRE

    Vaidhyanath, R; Thomas, A; MESSIOS, N

    2010-01-01

    Hypertrophic olivary degeneration is a result of a primary lesion damaging the dento-rubro-olivary pathway. It is a transynaptic form of degeneration and is unique, causing hypertrophy rather than atrophy of the inferior olivary nucleus. We report a case of bilateral hypertrophic olivary degeneration following surgical excision of a posterior fossa epidermoid cyst and review the relevant literature.

  7. From gonocytes to testicular cancer

    DEFF Research Database (Denmark)

    Rajpert-de Meyts, Ewa; Hoei-Hansen, Christina E

    2007-01-01

    . The most severe cases are a result of inherited genetic aberrations, but the etiology of the common sporadic testicular cancer must involve environmental factors, including maternal lifestyle and possibly an early exposure to endocrine disruptors. The effects of environmental factors are likely...... highly developed industrialized countries. A hypothesis was put forward that CIS originates from arrested fetal germ cells, thus testicular cancer is a developmental disease of germ-cell differentiation. This notion was supported by comparative studies of the gene expression at the protein and RNA level......, which demonstrated a close similarity of CIS to primordial germ cells and gonocytes with many features of embryonic stem cells. The arrest of germ-cell differentiation is thus the key first event, which may be followed by malignant transformation and overt germ-cell cancer in young adult age, usually...

  8. Polygenic susceptibility to testicular cancer

    DEFF Research Database (Denmark)

    Litchfield, Kevin; Mitchell, Jonathan S; Shipley, Janet; Huddart, Robert; Rajpert-De Meyts, Ewa; Skakkebæk, Niels E; Houlston, Richard S; Turnbull, Clare

    2015-01-01

    known TGCT susceptibility variants. The diagnostic performance of testicular biopsy and non-invasive semen analysis was also assessed, within a simulated combined screening programme. RESULTS: The area under the curve for the TGCT PRS model was 0.72 with individuals in the top 1% of the PRS having a...... discrimination, presently the case for population-level testing is not compelling. However, future advances, such as more routine generation of whole genome data is likely to alter the landscape. More targeted screening programs may plausibly then offer clinical benefit, particularly given the significant......BACKGROUND: The increasing incidence of testicular germ cell tumour (TGCT) combined with its strong heritable basis suggests that stratified screening for the early detection of TGCT may be clinically useful. We modelled the efficiency of such a personalised screening approach, based on genetic...

  9. Association of an Epidermoid Tumour with Ipsilateral Aneurysms of Middle Cerebral Artery Bifurcation and Anterior Communicating Artery

    Directory of Open Access Journals (Sweden)

    Gokhan KURT

    2010-06-01

    Full Text Available By this case report the authors are aimed to describe an unusual case of epidermoid tumour associated with ipsilateral two cerebral aneurysms. Radiological and clinical findings of a 45 year old male patient are described. Investigation of the patient revealed a right temporal lobe tumour and ipsilateral two aneurysms. The patient is treated with micro-neurosurgery successfully. Both the tumour and the right MCA aneurysm are interfereted in the same session. His pathological diagnose was epidermoid tumour. Togetherness of epidermoid tumours and cerebral aneurysms is a very rare entity. Further studies are needed to demonstrate the exact pathological and genetic mechanisms.

  10. CISS MR imaging findings of epidermoid tumor : comparison with spin-echo images

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yong Woo; Kim, Hak Jin; Choi, Sang Yoel; Heo, Jin Sam; Jung, Hoon Sik; Lee, Suck Hong; Kim, Byung Soo [Pusan National Univ. College of Medicine, Pusan (Korea, Republic of); Lee, Jong Wha [Ulsan Univ. Hospital, Ulsan (Korea, Republic of)

    1999-03-01

    To evaluate CISS MR imaging findings of epidermoid tumor in comparison with conventional spin-echo images. We studied 6 cases of epidermoid tumor in the subarachnoid space. We used a 1.5T MR unit to obtain CISS images(TR/TE/FA ; 12.3msec/5.9 msec/700) and T1- and T2- weighted spin-echo images. CISS MR imaging findings were evaluated with respect to tumor's signal intensity , contour, and relation with adjacent structures. Conspicuity of the tumor was compared between CISS and spin-echo images. A quantitative analysis was performed by measuring tumor to CSF contrast. In qualitative analysis, three radiologists independently compared CISS image and conventional spin-echo images for visibility of the tumor and graded them into three categories( poor, good, and excellent). Epidermoid tumors were located in the cerebellopontine angle in 4 cases, the prepontine cisstern in 1 case, and the cerebellopontine angle-prepontine cistern in 1 case. The tumors were hyperintense relative to brain parenchyma and hypointense relative to CSF on CISS images, were lobulated, encased adjacent cranial nerve and vessels, and invaginated into brain parenchyma. In qualitative analysis, CISS images showed clear demarcation between tumor and CSF, exact tumor extension, and tumor's relation with cranial nerves and vessels better than conventional spin-echo images. In quantitative analysis, the mean contrast values of tumor to CSF on T1-, T2-weighted images, and CISS images were 0.12, 0.06, and 0.52, respectively. The contrast value for CISS images was significantly higher than that for T1-and T2-weighted images(p<0.05). Epidermoid tumors in the subarachnoid space are better demonstrated on CISS images than on conventional spin-echo images. This special MR sequence can be added as a routine protocol in the diagnosis of subarachnoid epidermoid tumor.

  11. CARCINOMA PAPILAR DE TIROIDES EN QUISTE DEL CONDUCTO TIROGLOSO / Thyroglossal duct cyst with papillary carcinoma

    Scientific Electronic Library Online (English)

    Patricio, Cabané T; Patricio, Gac E; Francisco, Rodríguez M; Carolina, Morales O; Juan, Aldana L; Ignacio, Boza T; Cristina, Fernández E; José, Amat V.

    2015-04-01

    Full Text Available Introducción: En alrededor de 1-2% de los casos de quiste tirogloso pueden existir cambios neoplásicos, en su mayoría corresponden a carcinoma papilar de tiroides (75-85%). El objetivo de este trabajo es presentar 9 casos de carcinoma papilar de tiroides en quiste del conducto tirogloso, en cuanto a [...] su forma de presentación y manejo. Material y Método: Se registraron en forma retrospectiva datos de pacientes con diagnóstico de carcinoma papilar de tiroides en quiste del conducto tirogloso atendidos en el Hospital Clínico de la Universidad de Chile entre 1999-2014. Resultados: De 142 casos de pacientes operados por quiste del conducto tirogloso, se registraron 9 casos de cáncer papilar (6,34%). El promedio de edad de los pacientes fue de 32 años. El diámetro promedio de la lesión fue de 4,4 cm (DS 2,2 cm). Del total, 8 pacientes fueron sometidos a tiroidectomía total, se diagnosticó cáncer de tiroides en 3 de ellos, en 6 se asoció tratamiento con radioyodo. En sólo 1 paciente se realizó una disección linfonodal. El tiempo promedio de seguimiento fue de 85 meses; a la fecha la serie no ha presentado recurrencia ni mortalidad. Conclusiones: Si bien el manejo más seguro a largo plazo es la cirugía de Sistrunk, asociado a una tiroidectomía y eventual radioyodo, la resolución quirúrgica con tiroidectomía asociada debe ser considerada cuando la morbilidad no sea mayor que el beneficio teórico. Abstract in english Introduction: In about 1-2% of cases of thyroglossal cyst may be neoplastic changes, mostly correspond to papillary thyroid carcinoma (75-85%). The aim of this paper is to present 9 cases of papillary thyroid carcinoma in thyroglossal duct cyst. Materials and Methods: Data were recorded retrospectiv [...] ely from patients diagnosed with papillary thyroid carcinoma in thyroglossal duct cyst treated at Hospital Clinico Universidad de Chile between 1999-2014. Results: From 142 cases operated for thyroglossal duct cyst, 9 cases of papillary cancer (6.34%) were recorded. The average age was 32 years. The average diameter of the lesion was 4.4 cm (SD 2.2 cm). 8 patients underwent total thyroidectomy; a simultaneous thyroid cancer was diagnosed in 3 of them. In 6 cases was added iodine therapy. In only one patient a lymph nodal dissection was performed. We do not observe any surgical complication. A solid component in preoperative ultrasonographic study is suspicious of malignancy. The average follow-up time was 85 months. There is no recurrence or mortality in this group of patients. Conclusions: Although the safest long-term management is Sistrunk surgery associated with thyroidectomy and radioiodine in selected cases, these patients must be evaluated by a multidisciplinary group and thyroidectomy should be considered in high surgical volume center, in order to minimize complications.

  12. Quiste renal simple y polidactilia: A propósito de 1 caso

    Directory of Open Access Journals (Sweden)

    César Mustelier Fernández

    1999-09-01

    Full Text Available Se presentó el caso de una paciente de 23 años de edad a quien se le detectó asociación infrecuente de 2 anomalías congénitas: quiste renal único y polidactilia del pie derecho. Se reseñaron los aspectos clínicos y se mostraron los resultados de los estudios imagenológicos. Se revisó el tema.The case of a 23-year-old patient with an unfrequent association of 2 congenital anomalies: single renal cyst and polydactyly of the right foot was presented. The clinical aspects were briefly described and the results of the imaging studies were shown. The topic was reviewed.

  13. Quiste óseo aneurismático mandibular de tipo sólido Mandibular solid aneurysmal bone cyst

    Directory of Open Access Journals (Sweden)

    Marta Saldaña Rodríguez

    2013-06-01

    Full Text Available El quiste óseo aneurismático sólido es una lesión ósea benigna muy infrecuente de la que no existe consenso en relación a su origen etiopatogénico. Presenta características clínicas, radiológicas e histológicas inespecíficas, por lo que los estudios ultraestructurales son fundamentales para su diagnóstico y clasificación. El diagnóstico diferencial es extenso e incluye múltiples lesiones óseas como el granuloma reparativo de células gigantes e incluso tumores malignos como el osteosarcoma. El tratamiento de elección es la cirugía conservadora. La recidiva se debe fundamentalmente a la extirpación incompleta.Solid aneurysmal bone cyst is a rare benign bone lesion for which no consensus exists regarding its origin. It has nonspecific clinical, radiological and histological features so ultrastructural studies are essential for diagnosis and classification. The differential diagnosis is extensive and includes a variety of bone lesions, such as giant cell reparative granuloma, and even malignant tumors like osteosarcoma. The treatment of choice is conservative surgery. Recurrence is due mainly to incomplete resection.

  14. Correlación clínico-citohistológica de los quistes congénitos cervicales Clinical-cytohistological correlation of cervicofacial congenital cysts

    Directory of Open Access Journals (Sweden)

    L.D. Medina Vega

    2004-02-01

    Full Text Available Objetivo: Determinar la efectividad de los diagnósticos clínico y citológico en los quistes congénitos cervicofaciales. Método: Se realizó un estudio retrospectivo de los pacientes con diagnóstico clínico, citológico y/o histológico de quiste tirogloso, branquial y dermoide, atendidos en el Hospital Universitario «Arnaldo Milián Castro», durante cinco años. Se calculó la sensibilidad, especificidad y seguridad del diagnóstico clínico y la biopsia por aspiración con aguja fina (FNAC para cada quiste. Resultado: La seguridad del diagnóstico clínico fue de 94,1%, 92,2% y 98% para los quistes tirogloso branquial y dermoide respectivamente. Encontramos mayor tendencia al error clínico en los quistes branquiales, donde las confusiones más frecuentes se presentan con linfoadenopatías inflamatorias. La seguridad de la biopsia por aspiración con aguja fina fue de 96,1% y 94,1% para los quistes tirogloso y branquial respectivamente. Conclusiones: El diagnóstico clínico no es suficiente en ocasiones, por lo que es preciso recurrir a medios diagnósticos complementarios, como la biopsia por aspiración con aguja fina; sin embargo esta prueba no es 100% segura.Objective: To determine the effectiveness of clinical and cytological diagnosis in congenital cysts located in head and neck. Method: We were carried out a retrospective study of patients with clinical, cytological or histological diagnosis of thyroglossal, branchial and dermoid cyst, assisted in the University Hospital Arnaldo Milián Castro", during five years. It was calculated the sensibility, specificity and security of the clinical diagnosis and the Fine Needle Aspiration Biopsy for each cyst. Result: The security of the clinical diagnosis it was respectively of 94,1%, 92,2% and 98% for the thyroglossal, branchial and dermoid cysts. We find bigger tendency to the clinical error in branchial cysts, where the most frequent confusions are presented with inflammatory linfoadenopathy. The security of the Fine Needle Aspiration Biopsy was of 96,1% and 94,1% for the thyroglossal and branchial cysts respectively. Conclusions: Clinical diagnosis is not enough in occasions, for what is necessary to appeal to means complementary diagnoses, as the Fine Needle Aspiration Biopsy; however this test is not 100% sure.

  15. Correlación clínico-citohistológica de los quistes congénitos cervicales / Clinical-cytohistological correlation of cervicofacial congenital cysts

    Scientific Electronic Library Online (English)

    L.D., Medina Vega; E., Márquez Rancaño; J., Concepción Guzmán; R., Rodríguez Jiménez; J., Martín Pino.

    2004-02-01

    Full Text Available Objetivo: Determinar la efectividad de los diagnósticos clínico y citológico en los quistes congénitos cervicofaciales. Método: Se realizó un estudio retrospectivo de los pacientes con diagnóstico clínico, citológico y/o histológico de quiste tirogloso, branquial y dermoide, atendidos en el Hospital [...] Universitario «Arnaldo Milián Castro», durante cinco años. Se calculó la sensibilidad, especificidad y seguridad del diagnóstico clínico y la biopsia por aspiración con aguja fina (FNAC) para cada quiste. Resultado: La seguridad del diagnóstico clínico fue de 94,1%, 92,2% y 98% para los quistes tirogloso branquial y dermoide respectivamente. Encontramos mayor tendencia al error clínico en los quistes branquiales, donde las confusiones más frecuentes se presentan con linfoadenopatías inflamatorias. La seguridad de la biopsia por aspiración con aguja fina fue de 96,1% y 94,1% para los quistes tirogloso y branquial respectivamente. Conclusiones: El diagnóstico clínico no es suficiente en ocasiones, por lo que es preciso recurrir a medios diagnósticos complementarios, como la biopsia por aspiración con aguja fina; sin embargo esta prueba no es 100% segura. Abstract in english Objective: To determine the effectiveness of clinical and cytological diagnosis in congenital cysts located in head and neck. Method: We were carried out a retrospective study of patients with clinical, cytological or histological diagnosis of thyroglossal, branchial and dermoid cyst, assisted in th [...] e University Hospital Arnaldo Milián Castro", during five years. It was calculated the sensibility, specificity and security of the clinical diagnosis and the Fine Needle Aspiration Biopsy for each cyst. Result: The security of the clinical diagnosis it was respectively of 94,1%, 92,2% and 98% for the thyroglossal, branchial and dermoid cysts. We find bigger tendency to the clinical error in branchial cysts, where the most frequent confusions are presented with inflammatory linfoadenopathy. The security of the Fine Needle Aspiration Biopsy was of 96,1% and 94,1% for the thyroglossal and branchial cysts respectively. Conclusions: Clinical diagnosis is not enough in occasions, for what is necessary to appeal to means complementary diagnoses, as the Fine Needle Aspiration Biopsy; however this test is not 100% sure.

  16. Phthalate excretion pattern and testicular function

    DEFF Research Database (Denmark)

    Joensen, Ulla Nordström; Frederiksen, Hanne; Jensen, Martin Blomberg; Lauritsen, Mette Petri; Olesen, Inge Ahlmann; Lassen, Tina Harmer; Andersson, Anna-Maria; Jørgensen, Niels

    2012-01-01

    In animals, some phthalates impair male reproductive development and function. Epidemiological studies have reported inconsistent evidence of associations between phthalates and markers of human testicular function.......In animals, some phthalates impair male reproductive development and function. Epidemiological studies have reported inconsistent evidence of associations between phthalates and markers of human testicular function....

  17. Angiography of the testicular artery. IV

    International Nuclear Information System (INIS)

    Magnification angiography of the testis with selective injection into the testicular artery has been performed in patients with different lesions in the scrotum, either real or suggested. Characteristic angiographic appearances were found in epididymitis, testicular torsion, tumor, hematoma and hydrocele. (Auth.)

  18. Familial testicular cancer and developmental anomalies

    International Nuclear Information System (INIS)

    Familial occurrence belongs to factors followed in etiology and pathogenesis of testicular germ-cell tumors. Association with abnormal testicular development, or with other risk factors is relatively frequent. In our material 650 patients had been treated for testicular cancer in the period of 1981-1995. Familial occurrence was observed 7-times (1.08), most frequently in combination with cryptorchidism. Individual families were analyzed in details, including HLA typing. On basis of the observations the supplementation of initial examination of each patient with suspicious testicular cancer with detailed familiar history aimed also at the occurrence of urogenital developmental anomalies and tumors has been recommended. The knowledge about familial tumor occurrence in the first-degree relatives in combination with thorough testicular self-examination is being considered of great importance in the secondary prevention. (author)

  19. Radiation Therapy of Testicular Seminoma

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Hong Gyun; Oh, Do Hoon; Ha, Sung Whan [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1994-10-15

    Purpose: Testicular seminomas are radiosensitive and adjuvant radiation therapy after orchiectomy results in long term survival in early stage diseases. Ten year results of radiation therapy after orchiectomy and results of definitive treatment of recurrent seminoma are presented. Materials and Methods: Between August 1980 and February 1990, 32 patients with testicular seminomas were treated at the Department of Therapeutic Radiology, Seoul National University Hospital. Twenty-seven patients received radiation therapy after orchiectomy and 5 patients for treatment of recurrent tumors. Two of postoperatively treated patients and 2 of recurrent patients were excluded from the study because of incomplete treatment. Of the patients treated postoperatively. 18 were stage I, 5 were stage IIA, one was stage IIB, and one was stage IIC. There were 4 ipsilateral and 2 contralateral cryptorchids. Preoperatively, b-HCG levels were elevated in 5 patients. Median dose to pelvic and paraaortic lymph node area was 2900 cGy (1550-4550 cGy). One patient with stage I, 4 with stage IIA, and 1 with stage IIB received prophylactic mediastinal irradiation. Two patients were treated with chemotherapy before radiation therapy. Median follow-up period was 104(3-144) months. Result: Local control rates were 100% at 5 years after orchiectomy. Five year survival rates were 94.4% in Stage I and 100% in Stage II patients. One patient with stage I disease died 3 months after surgery due to mediastinal metastasis. All the 3 patients treated for recurrent disease are alive without disease. Conclusion: Postorchiectomy radiation to the pelvis and para-aortic area remains the treatment of choice for patient with early stage testicular seminoma. Radiation therapy is also an excellent treatment modality for recurrent seminoma.

  20. Carboplatin: a new platinum analog in the treatment of epidermoid carcinoma of the esophagus.

    Science.gov (United States)

    Sternberg, C; Kelsen, D; Dukeman, M; Leichman, L; Heelan, R

    1985-11-01

    Thirty-one patients with advanced epidermoid carcinoma of the esophagus were treated with carboplatin (CBDCA), a second-generation cisplatin analog. Thirty patients were evaluable for response. Major responses (complete response) were seen in two patients (7%; 95% confidence limits, 1%-20%). The median survival from initiation of the protocol was 3 months (range, 0.1-16). Neither renal dysfunction nor emesis was a significant problem with CBDCA; hematologic toxicity was dose-limiting. Thrombocytopenia was more marked than leukopenia. CBDCA is a well-tolerated cisplatin analog that produced two complete responses in patients with advanced epidermoid carcinoma of the esophagus, where such responses are rarely observed. Although the observed response rate was only 7%, the 95% confidence limits overlap those previously reported for cisplatin (12%-31%). PMID:3912041

  1. Epidermoid cyst of the outer ear: A case report and review of literature

    Directory of Open Access Journals (Sweden)

    Alka M Dive

    2012-01-01

    Full Text Available The purpose of this article is to present a rare case of epidermoid cyst of the outer ear in a 38-year-old male patient. During clinical examination, a soft, cystic, globular, and non-tender swelling with restricted motility and well-defined margins was seen in the retroauricular region. Skin over the swelling was normal and not attached to it. The chosen treatment was total surgical removal. The histopathological findings confirmed the diagnosis of epidermoid cyst, characterized by presence of cyst cavity lined by stratified squamous epithelium with orthokeratin production. The lumen was filled with keratin. The connective tissue capsule consisted of fibrocellular stroma with numerous endothelial lined blood capillaries, which were engorged with red blood cells. The proposed treatment was considered successful, as there was no recurrence.

  2. Intradiploic epidermoid tumor of temporal bone X-ray, CT, MR Imaging

    OpenAIRE

    Shibani Mehra; Garga Umesh Chandra; Suresh Kumar

    2012-01-01

    Intradiploic epidermoid tumors are extremely uncommon. About 200 cases have been reported in literature. These lesions are caused by inclusion of ectodermal cells in the bone tissue during neural tube closure. These tumors either remain asymptomatic or are incidentally detected or they may present as a palpable lump. They can erode the bone and involve the brain parenchyma due to their proximity to the brain. Radiological imaging is very helpful in accurate diagnosis of these lesions and in d...

  3. [Fertility in testicular cancer patients].

    Science.gov (United States)

    Shin, Takeshi; Miyata, Akane; Arai, Gaku; Okada, Hiroshi

    2015-03-01

    Testicular cancer(TC)is the most common and curable cancer affecting men of reproductive age. Successful treatment approaches have resulted in longer life expectancy in TC survivors. The most frequently used treatment for TC is a combination of inguinal orchiectomy, and either radiotherapy or cisplatin-based chemotherapy. In many TC patients, sperm quality is already abnormal and there may even be a lack of viable spermatozoa at the time of diagnosis. Therefore, the effect of cancer treatment on fertility is a potentially significant issue. Fertility preservation in these men has become essential and needs to be discussed prior to the start of cancer treatment. The only currently established fertility preservation method is the cryopreservation of sperm before therapy. For most patients seeking cryopreservation, the semen sample is collected via masturbation. If the patient is unable to ejaculate for any reason, other techniques such as vibratory stimulation and electroejaculation can be performed. In azoospermic or severely oligozoospermic patients, testicular sperm extraction at the time of the inguinal orchiectomy is a useful technique for obtaining spermatozoa before cytotoxic therapy. We herein present an overview of the current topics on fertility in TC patients, including the effects of surgery, chemotherapy, and radiation therapy. We also describe the strategy for fertility preservation in these patients. PMID:25812494

  4. Ictus isquémico mesencefálico aislado secundario a ruptura de quiste dermoide / Isolated mesencephalic stroke related to a ruptured intracranial dermoid cyst

    Scientific Electronic Library Online (English)

    J.M., Ramírez-Moreno; M., Ortega-Martínez; M.A., Fernández-Gil; L.M., Bernal-García; V., Bejarano-Moguel; I., Fernández-Portales; M.J., Gómez-Baquero; J.M., Cabezudo-Artero.

    2009-06-01

    Full Text Available Los quistes dermoides son lesiones benignas de origen embrionario que representan del 0.04 a 0,25% de todos los tumores intracraneales. Estos quistes ocasionalmente pueden romperse diseminándose el contenido graso intraquístico al espacio subaracnoideo y/o los ventrículos laterales. En este caso pue [...] de provocar diversas manifestaciones clínicas de forma aguda o retardada. El debut de este tipo de tumor con un ictus agudo está escasamente reflejado en la literatura. Presentamos el caso de una mujer de 26 años con un infarto mesencefálico aislado secundario a la ruptura de un quiste dermoide. Discutimos el mecanismo fisiopatológico supuesto y realizamos una revisión de los casos recogidos en la literatura. Abstract in english Dermoids cysts are embrionary benign lesions that comprise approximately 0.04-0.25% of all intracranial tumors. Occasionally they break and spread their content into subarachnoid space and/or lateral ventricles causing several acute or delayed symptoms. Debut of this type of tumor as acute stroke is [...] poorly reflected in literature. We present a 26-year-old woman with a isolated mesencephalic infarct secondary to spontaneous rupture of a dermoid cyst. We discuss the possible pathophysiological mechanisms for this condition and review the literature.

  5. Isolated thoracic (D5 intramedullary epidermoid cyst without spinal dysraphism: A rare case report

    Directory of Open Access Journals (Sweden)

    Sudhansu Sekhar Mishra

    2015-01-01

    Full Text Available Spinal epidermoid cyst, congenital or acquired, is mainly congenital associated with spinal dysraphism, rarely in isolation. Intramedullary epidermoid cysts (IECs are rare with less than 60 cases reported so far; isolated variety (i.e., without spinal dysraphism is still rarer. Complete microsurgical excision is the dictum of surgical treatment. A 14-year-old boy presented with 4-month history of upper backache accompanied with progressive descending paresthesia with paraparesis with early bladder and bowel involvement. His condition deteriorated rapidly making him bedridden. Neurological examination revealed upper thoracic myeloradiculopathy probably of neoplastic origin with sensory localization to D5 spinal level. Digital X-ray revealed no feature suggestive of spinal dysraphism. Contrast magnetic resonance imaging (MRI characteristics clinched the presumptive diagnosis. Near-total microsurgical excision was done leaving behind a small part of the calcified capsule densely adhered to cord. Histopathological features were confirmative of an epidermoid cyst. Postoperatively, he improved significantly with a gain of motor power sufficient to walk without support within a span of 6 months. Spinal IECs, without any specific clinical presentation, are often diagnosed based upon intraoperative and histopathological findings, however early diagnosis is possible on complete MRI valuation. Complete microsurgical excision, resulting in cessation of clinical progression and remission of symptoms, has to be limited to sub-total or near-total excision if cyst is adherent to cord or its confines.

  6. Resection of large recurrent third ventricular epidermoid tumors through the posterior interhemispheric transcallosal approach.

    Science.gov (United States)

    Hendricks, Benjamin K; Cohen-Gadol, Aaron A

    2016-01-01

    Epidermoid cysts or tumors comprise 1% of intracranial tumors with a predilection for the cerebellopontine angle or parasellar cisterns. These tumors are derived from an ectopic ectodermal implant seeded between fusing ectodermal surfaces. This results in a benign proliferation of stratified squamous epithelium along a cyst wall with a lumen composed of hyperkeratotic material derived from the desquamating cells. Surgical intervention is the treatment of choice for symptomatic patients. There is no role for radiotherapy or chemotherapy in the treatment of these lesions, including for residual or recurrent disease. The inherent adhesion of the proliferating epithelial lining to surrounding neurovascular structures significantly complicates attempts at gross-total resection. Epidermoid tumors or cysts are rarely reported within the third ventricular region. In this video, the authors demonstrate the technique of right-sided posterior interhemispheric transcallosal approach for maximal resection of a complex recurrent third ventricular epidermoid tumor with lateral ventricular extension. The video can be found here: https://youtu.be/wbXp7mc0vT4 . PMID:26722690

  7. Radiosurgery of epidermoid tumors with gamma knife. Possiblity of radiosurgical nerve decompression

    International Nuclear Information System (INIS)

    Long-term results of radiosurgery for epidermoid tumors are reported. There are 7 cases including 2 males and 5 females, ages ranging from 6 to 46 (mean: 33.3 years). At radiosurgery whole tumor was covered in 4 cases and partially covered in 3 cases in attempting to relieve cranial nerve signs like trigeminal neuralgia and facial spasm. The mean maximum and marginal doses were 25.6 Gy and 14.6 Gy respectively. In the mean follow-up of 52.7 months, all the tumors showed good tumor control without any progression and tumor shrinkage has been confirmed in 2 out of the 7 cases. Symptomatic trigeminal neuralgia improved or disappeared in all 4 cases and facial spasm disappeared in one. No neurological deterioration was found in any of the cases after the treatment. In conclusion, it is apparent that epidermoid tumors do respond well to radiosurgery and the accompanying hyperactive dysfunction of cranial nerves is significantly improved by gamma knife treatment with either entire or partial tumor coverage. Therefore the radiosurgical nerve decompression for epidermoid tumor seems to be achieved by gamma-radiosurgery. (author)

  8. Evaluation of radiotherapy and chemoradiotherapy for anal canal epidermoid cancer in our center

    International Nuclear Information System (INIS)

    The efficacy and safety of radiotherapy (RT) and chemoradiotherapy (CRT) for anal canal epidermoid cancer were evaluated. Twenty-four patients with anal canal epidermoid cancer were treated in our center between 1988 and 2006, consisting of 13 patients treated by RT and 11 by CRT. In these patients, the efficacy and safety of RT and CRT were evaluated in terms of adverse events, 5-year local control rates, 5-year disease-free survival rates, and 5-year survival rates. No grade 3 or higher adverse events were noted in patients receiving RT. In contrast, anorexia, diarrhea, neutropenia, and anemia were observed in 33.3%, 10%, 33.3%, and 10%, respectively, of the patients receiving CRT. The anal preserving rate, 5-year local control rate, 5-year disease-free survival rate, and 5-year survival rate were 66.7%, 73%, 77.5%, and 88.4%, respectively. RT and CRT for anal canal epidermoid cancer should be first-line treatments because of their safety and efficacy. (author)

  9. Splenic Epidermoid Cyst during Pregnancy; Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Majid Forouzesh

    2013-10-01

    Full Text Available Cystic disease of the spleen is not frequently encountered in surgical practice. It is broadly classified as parasitic and non-parasitic, the latter being a rare entity. In this case report, an epidermoid cyst of spleen led to acute abdomen in young age pregnant woman is presented.A 26-year-old woman with 15 weeks gestational age second pregnancy referred to emergency ward with left upper quadrant pain and tenderness that ultra sonography revealed large cyst (100х110mm with internal echo in spleen in favor of hydatic cyst or abscess. The patient was managed medically for one week but developed her abdominal pain, epigastric fullness, anorexia and fever. New sonography was done for her and large cyst was detected in spleen (120х110mm. She had severe pain accompanied with anorexia and vomiting. Fetus was normal in sonography. Exploratory laprotomy with splenectomy was performed. Splenomegaly (200х130х90mm with a cyst without any adhesion and inflammation was detected. Histopathology examination showed epidermoid cyst of spleen. (140х10х90mm. Though splenic epidermoid cyst is an uncommon entity, it should be considered in the differential diagnosis of an abdominal mass in a young individual. An attempt should be made to preserve the spleen provided there is adequate parenchyma otherwise splenectomy is the rule.

  10. Testicular cancer: addressing the psychosexual issues.

    LENUS (Irish Health Repository)

    Moore, Annamarie

    2012-01-31

    Testicular cancer is the most common malignancy in men aged 15-35 years and predominantly occurs at a time in a man\\'s life when important decisions about marriage, starting a family and a professional career are being made. While treatments for testicular cancer are very successful, they can have a major impact on the person\\'s sexuality and sense of self. The focus of this article is on exploring the impact of cancer treatments for testicular cancer on men\\'s sexuality and how nurses can respond to their concerns in a sensitive and informed manner.

  11. Quistes dermoides nasoetmoidales manejo quirúrgico Surgical management of nasoethmoidal dermoide cysts

    Directory of Open Access Journals (Sweden)

    Carlos Giugliano V.

    2002-07-01

    Full Text Available Los quistes dermoides nasoetmoidales son malformaciones congénitas infrecuentes, de origen ectodérmico. Clínicamente pueden presentarse como un nódulo subcutáneo y/o como un orificio fistuloso cutáneo con pelos, a cualquier nivel de la línea media nasal. A diferencia de los dermoides de otras localizaciones, existe la posibilidad de compromiso de estructuras profundas y extensión intracraneal, pudiendo asociarse a graves complicaciones, como meningitis y abscesos cerebrales. Por este motivo, los dermoides nasoetmoidales, demandan una adecuada evaluación imaginológica para planificar el abordaje quirúrgico, que permita la extirpación completa de la lesión. Por las características singulares de los quistes dermoides nasoetmoidales se consideró de interés presentar 3 casos clínicos de esta poco frecuente e interesante patología, tratados en la Unidad de Cirugía Plástica del Hospital de Niños Dr. Roberto del Río, entre los años 1999 y 2001. Se discuten posteriormente algunos aspectos relacionados con su epidemiología, etiopatogenia, evaluación y manejo quirúrgicoNasoethmoidal dermoide cysts are infrequent congenital malformations of ectodermal origin. Clinically they can present as a subcutaneous nodule and/or a cutaneous fistula with hair at whatever level in the nasal midline. Differing from dermoide cysts in other parts there exists the possibility of deep structures compromise and intracranial extension, associated ar not severe complications such as meningitis and cerebral abscesses. For this reason nasoethmoidal dermoide cysts need a meticulous radiological evaluation in order to plan surgery that allows the complete removal of the lesion. For these singular characteristics we consider it of interest to present 3 cases of this infrequent and interesting pathology, treated in the Plastic Surgery Unit in the Roberto del Río Childrens Hospital between 1999 and 2001. We discuss some aspects of epidemiology, aetiopathology and surgical evaluation and management.

  12. Testicular myeloid sarcoma: case report

    Scientific Electronic Library Online (English)

    Luzia Beatriz Ribeiro, Zago; Antônio Alexandre Lisbôa, Ladeia; Renata Margarida, Etchebehere; Leonardo Rodrigues de, Oliveira.

    Full Text Available Myeloid sarcomas are extramedullary solid tumors composed of immature granulocytic precursor cells. In association with acute myeloid leukemia and other myeloproliferative disorders, they may arise concurrently with compromised bone marrow related to acute myeloid leukemia, as a relapsed presentatio [...] n, or occur as the first manifestation. The testicles are considered to be an uncommon site for myeloid sarcomas. No therapeutic strategy has been defined as best but may include chemotherapy, radiotherapy and/or hematopoietic stem cell transplantation. This study reports the evolution of a patient with testicular myeloid sarcoma as the first manifestation of acute myeloid leukemia. The patient initially refused medical treatment and died five months after the clinical condition started.

  13. Simultaneous acute appendicitis with right testicular torsion

    OpenAIRE

    Akhtar, Tanveer; Das, Pranjal Kumar; Singh, Nitin; Paramesh, Haralappa

    2012-01-01

    We present a child with both acute appendicitis and torsion of the right testis presenting at the same time. Testicular torsion possibly occurring due to vomiting in acute appendicitis so far has not been reported in the literature.

  14. Presentación inusual de un quiste dentigero en paciente pediatrico: Reporte de un caso y revisión de la literaturaRomero Yulis, Jiménez Cecilia. Hernández

    Scientific Electronic Library Online (English)

    Patricia, Alexis Ganai.

    Full Text Available El quiste dentígero es el quiste Odontogénico mas frecuente, generalmente se presenta rodeando la corona de un diente impactado, afecta a los caninos superiores y terceros molares inferiores, con mayor predilección en el sexo masculino, entre la segunda y tercera década de la vida . A continuación s [...] e presenta un caso clínico de un quiste dentígero mandibular inusual por presentar aspecto clínico y radiográfico de Osteomielitis crónica con osteítis proliferativa (Osteomielitis de Garré), en un paciente femenino de 7 años de edad con una evolución de 2 meses, Así mismo se describe la conducta clínica que se tomó con respecto al caso para llegar al diagnóstico definitivo. Abstract in english The denture quiste it is the most frequent to surround the tooth, it affect the upper caninos and third below molars, the most affected is the male sex, between the second and third decade of life. It is showed a clinic case of a dental jaw quiste with an unusual apparience that suggest a Garre’s Os [...] teomyelitis cronic in a 7 year female patient, with an evolution of two months. Patient was subject to clinical, radiography and hystopatology test to confirm the final diagnostics of the lesion, and its described the clinical approachment in order to become the definitive diagnosis.

  15. Cadmium-induced testicular injury

    International Nuclear Information System (INIS)

    Cadmium (Cd) is an environmental toxicant and an endocrine disruptor in humans and rodents. Several organs (e.g., kidney, liver) are affected by Cd and recent studies have illustrated that the testis is exceedingly sensitive to Cd toxicity. More important, Cd and other toxicants, such as heavy metals (e.g., lead, mercury) and estrogenic-based compounds (e.g., bisphenols) may account for the recent declining fertility in men among developed countries by reducing sperm count and testis function. In this review, we critically discuss recent data in the field that have demonstrated the Cd-induced toxicity to the testis is probably the result of interactions of a complex network of causes. This is likely to involve the disruption of the blood-testis barrier (BTB) via specific signal transduction pathways and signaling molecules, such as p38 mitogen-activated protein kinase (MAPK). We also summarize current studies on factors that confer and/or regulate the testis sensitivity to Cd, such as Cd transporters and metallothioneins, the impact of Cd on the testis as an endocrine disruptor and oxidative stress inducer, and how it may disrupt the Zn2+ and/or Ca2+ mediated cellular events. While much work is needed before a unified mechanistic pathway of Cd-induced testicular toxicity emerges, recent studies have helped to identify some of the likely mechanisms and/or events that take place during Cd-induced testis injury. Furthermore, some of the recent studies have shed lights on potential therapeutic or preventive approaches that can be developed in future studies by blocking or minimizing the destructive effects of Cd to testicular function in men.

  16. Testicular blood flow in varicocele

    International Nuclear Information System (INIS)

    Radioisotopic scrotal angiography was applied for study of testicular blood flow of patients with varicocele. Following iv. bolus injection of 10 ∼ 20 mCi of Tc human serum albumine, Tc RBC or Tc pertechnetate, time activity curve of radioactivity at corresponding bilateral areas of scrotum was simultaneously generated and compared. Eighty-four patients with overt varicocele (grade 2 and 3) at left side only, were selected for the present study and eight healthy young volunteers were studied as a control group. Three patterns of time activity curves were recognized. They are as follows. Type 1, where radioactivity was accumulated quickly in left side and then decreased gradually. Bilateral time activity curves were asymmetrical. Type 2, where time activity curves rose gradually and to a higher level at the left side than at the right side. Type 3, where bilateral time activity curves increased gradually, and symmetrically. All of the control group showed the same pattern as Type 3. Of the 84 patients examined, 34 patients showed Type 1, including 7 with grade 2 and 27 with grade 3. Twenty-four patients showed Type 2. consisting of 12 with grade 2 and 12 with grade 3. Twenty-six patients showed Type 3, consisting of 14 with grade 2 and 12 with grade 3. We presumed the following about testicular blood flow in varicocele: Type 1 pattern shows retrograde blood flow from the renal vein to the internal spermatic vein, Type 2 pattern shows poor venous return through the internal spermatic vein and Type 3 pattern shows good venous return though the presence of dilatated pampiniform plexus. (author)

  17. Testicular cancer and HPV semen infection

    OpenAIRE

    AlbertoFerlin

    2012-01-01

    Testicular cancer represents the more frequent solid tumor affecting males aged 15–35 years. In the last decades, its incidence showed a progressive increased probably due to genetic and environmental factors. Despite exposure to some viruses such as HIV, HCV, EBV, and HPV is frequently related to cancer development, there are no studies aimed to evaluate the possible implication of viral infections in the pathogenesis of testicular cancer. In this study, we analyzed sperm parameters and prev...

  18. [Epidemiology and risk factors of testicular tumours].

    Science.gov (United States)

    Kozłowski, Piotr; Starosławska, Elżbieta; Szumiło, Justyna; Jankiewicz, Małgorzata; Kozłowska, Magdalena; Burdan, Franciszek

    2016-04-29

    Testicular tumours are rare neoplasms, which most commonly affects men aged 25 to 35 years. Among young adult males it is the most common cause of testicular swelling. In recent decades, the number of cases of testicular tumours has greatly increased. The most significant predisposing factors are cryptorchidism and some endocrine disorders, especially increased levels of gonadotropins and female sex hormones. Testicular trauma, inguinal hernia, extreme values of body mass index (BMI), high-calorie diet rich in dairy products as well as high social status are also regarded as risk factors. Furthermore, some chromosomal abnormalities like increased number of chromosomes 7, 8. 12, 21 and X, loss of chromosomes 4, 5, 11, 13, 18, or Y, mutation in the gene Xq27; as well as multiplied copy of the gene i(12p) are associated with tumor development. It has been proven that high testosterone levels and regular physical activity may prevent testicular tumours. Since one of the first sign the lesion is often a lump or swelling of the testis and the appearance of abnormal structure in the scrotum routine testicular self-examination seems to be important in early detection. In all suspected cases an immediate ultrasound examination of both testicles is highly recommended. It is also advised to conduct a computerized tomography (CT) and a positron emission tomography (PET) scan for staging of the tumor to select the best mode of treatment. PMID:27137819

  19. Occupational Causes of Testicular Cancer in Adults

    Directory of Open Access Journals (Sweden)

    L Fritschi

    2010-09-01

    Full Text Available Testicular cancer is one of the commonest cancers in men of working age, and is increasing in incidence in Europe and North America. One suggested mechanism of causation is that there is impaired differentiation of germ cells in the pre- or perinatal period, followed by malignant transformation in later life, possibly by a hormonal mechanism. Endocrine disrupting chemicals (EDCs have been a major focus of interest for etiological research into testicular cancer because they interact with various hormonal pathways. Several EDCs including bisphenol A, phthalates, metals, polychlorinated biphenyls, and organochlorines have been investigated, but there are few studies and those that exist have not been able to assess exposure well. In addition, several studies, particularly those with better exposure assessment, have suggested that workers in electrical occupations have increased risks of testicular cancer. Electromagnetic radiation may have subthermal effects or may disrupt hormone release. Chronodisruption such as due to shift-work could potentially increase the risk of testicular cancer via disruption of hormonal cycles, but only one study has so far investigated this possibility. Lastly, solvent exposure, particularly to dimethylformamide, has been suggested to be associated with testicular cancer, but almost all these studies are based on job title only, with no specific assessment of solvent exposure. In conclusion, there is little evidence available on which to base definitive statements about occupational causes of testicular cancer. Future studies need to improve exposure assessment and develop ways to adjust for possible prenatal factors.

  20. Quiste óseo aneurismático mandibular de tipo sólido / Mandibular solid aneurysmal bone cyst

    Scientific Electronic Library Online (English)

    Marta, Saldaña Rodríguez; Maria Fe, García Reija; Belén, García-Montesinos Perea; Marta, Mayorga Fernández; Ramón Carlos, Saiz Bustillo.

    2013-06-01

    Full Text Available El quiste óseo aneurismático sólido es una lesión ósea benigna muy infrecuente de la que no existe consenso en relación a su origen etiopatogénico. Presenta características clínicas, radiológicas e histológicas inespecíficas, por lo que los estudios ultraestructurales son fundamentales para su diagn [...] óstico y clasificación. El diagnóstico diferencial es extenso e incluye múltiples lesiones óseas como el granuloma reparativo de células gigantes e incluso tumores malignos como el osteosarcoma. El tratamiento de elección es la cirugía conservadora. La recidiva se debe fundamentalmente a la extirpación incompleta. Abstract in english Solid aneurysmal bone cyst is a rare benign bone lesion for which no consensus exists regarding its origin. It has nonspecific clinical, radiological and histological features so ultrastructural studies are essential for diagnosis and classification. The differential diagnosis is extensive and inclu [...] des a variety of bone lesions, such as giant cell reparative granuloma, and even malignant tumors like osteosarcoma. The treatment of choice is conservative surgery. Recurrence is due mainly to incomplete resection.

  1. Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer

    DEFF Research Database (Denmark)

    Hoei-Hansen, Christina E; Holm, Mette; Rajpert-De Meyts, Ewa; Skakkebæk, Niels Erik

    2003-01-01

    This study was prompted by a hypothesis that testicular germ cell cancer may be aetiologically linked to other male reproductive abnormalities as a part of the so-called 'testicular dysgenesis syndrome' (TDS). To corroborate the hypothesis of a common association of germ cell cancer with testicul...

  2. Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations

    DEFF Research Database (Denmark)

    Skakkebaek, N E; Rajpert-De Meyts, E; Jørgensen, N; Main, K M; Leffers, H; Andersson, A-M; Juul, A; Jensen, T K; Toppari, J

    2007-01-01

    Recently a worldwide rise in the incidence of testicular germ cell cancer (TGCC) has been repeatedly reported. The changing disease pattern may signal that other testicular problems may also be increasing. We have reviewed recent research progress, in particular evidence gathered in the Nordic...... countries, which shows strong associations between testicular cancer, undescended testis, hypospadias, poor testicular development and function, and male infertility. These studies have led us to suggest the existence of a testicular dysgenesis syndrome (TDS), of which TGCC, undescended testis, hypospadias....../disorders of sex differentiation and male fertility problems may be symptoms with varying penetration. In spite of their fetal origin, most of the TDS symptoms, including TGCC and poor semen quality, can only be diagnosed in adulthood. Data from a Danish-Finnish research collaboration strongly suggest that...

  3. Public awareness of testicular cancer and testicular self-examination in academic environments: a lost opportunity

    Directory of Open Access Journals (Sweden)

    Henry A. A. Ugboma

    2011-01-01

    Full Text Available BACKGROUND: Although testicular cancer is the most common cancer among 18- to 50-year-old males, healthcare providers seldom teach testicular self-examination techniques to clients, thus potentially missing opportunities for early detection. This form of cancer is easily diagnosable by testicular self-examination and is 96% curable if detected early. Periodic self-examination must be performed for early detection. Knowledge deficits and sociocultural norms contribute to low levels of health-related knowledge in most patients, resulting in undue delays before seeking medical advice. OBJECTIVE: Our aim is to assess the level of awareness of testicular cancer and the prevalence of the practice of testicular self-examination in academic environments to enable appropriate interventions. METHOD: A cross-sectional survey was administered to 750 consecutive males aged 18-50 years in three tertiary institutions in Port Harcourt from October 2008 to April 2009. RESULT: Knowledge or awareness of testicular cancer was poor. Almost all of the respondents were unaware that testicular lumps may be signs of cancer. A lump was typically construed as a benign carbuncle or something that could resolve spontaneously. The main factor contributing to respondents' lack of knowledge of testicular cancer was that few reported that they were "ever taught about testicular self-examination." CONCLUSION: Young adult men are unaware of their risk for testicular cancer, which is the most common neoplasm in this age group. Healthcare providers are not informing them of this risk, nor are they teaching them the simple early detection technique of self-examination of the testes.

  4. Characteristic findings of metrizamide CT cisternography in an epidermoid in the posterior fossa

    International Nuclear Information System (INIS)

    A case of epidermoid cyst in the posterior fossa showing a characteristic finding upon metrizamide CT cisternography is reported. A 42-year-old man was admitted with gait disturbance. The abnormal signs were trunucal ataxia, gait ataxia, left cerebellar sign and nystagmus. A CT scan revealed a large, low-density area and the fourth ventricle could not be seen clearly. Absorption values were in the range of 5 - 18 Hounsfield units. There was no change in the absorption values of the lesion following intravenous injection of contrast medium. Metrizamide CT cisternography was performed No remarkable change was seen 1 hour after intrathecal injection of metrizamide. However, metrizamide irregularly surrounded the left margin of the low-density area 3 hours after intrathecal injection. Moreover, metrizamide stained the area heterogeneously like a honeycomb or sponge at 6 hours. Finally, only a small amount of metrizamide remained in this area after 24 hours. Suboccipital craniectomy revealed a pearly tumor in the cisterna magna, wrapped in a thin white capsule and partially adherent to the cerebellomedullary junction. The tumor was totally removed. Histopathological investigation showed stratified squamous epithelium with keratinous material. A honeycomb- or sponge-like image seems to be a characteristic finding in metrizamide CT cisternography of the epidermoid cyst. This finding has not been previously reported. However, pneumoencephalographical findings in some cases of epidermoid were reported as crumb- or sponge-like images. These images were thought to be caused by air covering the surface of the pearly tumor. These images should be similar to the one found in the present study using CT cisternography. (author)

  5. A case of epidermoid cyst in an intrapancreatic accessory spleen mimicking pancreas neoplasms: MRI with DWI.

    Science.gov (United States)

    Kwak, Min Kyu; Lee, Nam Kyung; Kim, Suk; Han, Ga Jin; Seo, Hyung Il; Park, Do Youn; Lee, So Jeong; Kim, Tae Un

    2016-01-01

    We report on a rare case of an epidermoid cyst in an intrapancreatic accessory spleen (ECIAS) that presented as a cystic lesion in the tail of the pancreas, in a 21-year-old woman. ECIAS is very rare; thus, accurate diagnosis before surgery is difficult. When a wall within the lesion presents with similar imaging features to accessory splenic tissues on magnetic resonance imaging with diffusion-weighted imaging, ECIAS should be considered in the differential diagnosis of cystic lesions in the tail of the pancreas. PMID:26422768

  6. Urgent penectomy in a patient presenting with epidermoid carcinoma of the penis associated to myiasis

    OpenAIRE

    Antonio J. Tavares; Rodrigo Barros; Favorito, Luciano A.

    2007-01-01

    The objective of this study is to describe the case of a patient presenting advanced epidermoid carcinoma of the penis associated to myiasis. A 41-year-old patient presenting with a necrotic lesion of the distal third of the penis infested with myiasis was attended in the emergency room of our hospital and was submitted to an urgent penectomy. This is the first case of penile cancer associated to myiasis described in the literature. This case reinforces the need for educative campaigns to red...

  7. Urgent penectomy in a patient presenting with epidermoid carcinoma of the penis associated to myiasis

    Directory of Open Access Journals (Sweden)

    Antonio J. Tavares

    2007-08-01

    Full Text Available The objective of this study is to describe the case of a patient presenting advanced epidermoid carcinoma of the penis associated to myiasis. A 41-year-old patient presenting with a necrotic lesion of the distal third of the penis infested with myiasis was attended in the emergency room of our hospital and was submitted to an urgent penectomy. This is the first case of penile cancer associated to myiasis described in the literature. This case reinforces the need for educative campaigns to reduce the incidence of this disease in developing countries.

  8. Subtotal resection and omentoplasty of the epidermoid splenic cyst: a case report

    Science.gov (United States)

    Spahija, Gazmend S; Hashani, Shemsedin I; Osmani, Eshref A; Hoxha, Sejdullah A; Hamza, Astrit H; Gashi-Luci, Lumturije H

    2009-01-01

    Introduction Nonparasitic splenic cysts are uncommon clinical entity and because of it, there is no information regarding their optimal surgical treatment. Case presentation A 41-years-old female with incidentally diagnosed nonparasitic splenic cyst which initially was asymptomatic. After two years of follow up, the patient underwent surgery; subtotal cystectomy and omentoplasty as an additional procedure. Postoperative course was uneventful. Conclusion Short and mid term results showed that near total cystectomy with omentoplasty was a safe successful procedure for treatment of epidermoid splenic cyst. PMID:19829799

  9. Combined regional chemotherapy and radiation therapy in the treatment of epidermoid carcinoma in the oro-facial region

    International Nuclear Information System (INIS)

    Treatment was studied of oro-facial epidermoid carcinoma by combined chemo- and radiotherapy and eventual surgery. Cytostatic drugs were applied intraarterially. After a monocytostatic treatment trial with Methotrexate (MTX), a combined cytostatic program was developed alternating two cytostatic drugs, viz., MTX and Bleomycin (BLM). The usefulness of chemotherapy and its inclusion in the treatment of epidermoid carcinoma in the oro-facial region was found justified for combined therapy. The selected intraarterial administration, however, is not suitable for routine application. For this reason, the combination irradiation or surgical therapy with chemotherapy was adopted. (author)

  10. Epigenetic: a molecular link between testicular cancer and environmental exposures?

    Directory of Open Access Journals (Sweden)

    DavidHVOLLE

    2012-11-01

    Here we will review chromatin modifications which can affect testicular physiology leading to the development of testicular cancer; and highlight potential molecular pathways involved in these alterations in the context of environmental exposures.

  11. Discovery – Cisplatin and The Treatment of Testicular and Other Cancers

    Science.gov (United States)

    Prior to the discovery of cisplatin in 1965, men with testicular cancer had few medical options. Now, thanks to NCI research, cisplatin and similar chemotherapy drugs are known for curing testicular and other forms of cancer.

  12. Prognóstico de tumores testiculares germinativos

    Directory of Open Access Journals (Sweden)

    Dias Neto José Anastácio

    2002-01-01

    Full Text Available OBJETIVO: Investigar as características e a evolução de homens adultos portadores de tumores germinativos do testículo. MÉTODOS: Estudamos as características e a evolução 29 pacientes tratados (14 seminomas e 15 não seminomas. O tempo médio de seguimento foi de 56 meses para os seminomas e de 40 meses para os não seminomatosos. Todos foram submetidos a orquiectomia. Nos estádios II e III associou-se radioterapia para os seminomas, e quimioterapia e linfadenectomia para os não seminomatosos. RESULTADOS: As queixas mais freqüentes foram aumento de volume testicular (57% e dor (30%. Nos seminomas a idade média foi de 41,2 anos e nos não seminomas foi de 29,2 anos. Antecedente de criptorquidia foi assinalada em 28,5% dos seminomas e em 15,5% dos não seminomatosos. As proporções respectivas de estádios I, II e III foram de 79%, 14% e 7% em seminomas, e 40%, 27% e 33% em não seminomas. Os seminomas não provocaram elevação dos marcadores AFP ou b-HCG enquanto os não seminomatosos elevaram esses marcadores respectivamente em 46,6% e 33,3% dos casos. Morte pela doença ocorreu em 1 caso de seminoma e 3 de não seminomas, mas não houve diferença na sobrevida entre os grupos. CONCLUSÃO: A criptorquidia continua sendo um fator predisponente importante na etiologia dos tumores germinativos. Apesar dos tumores não seminomatosos se apresentarem em estádios mais avançados a sobrevida dos pacientes não difere da apresentada pelos portadores de seminomas.

  13. Prevalencia de quistes odontogénicos: Hospital Regional Valdivia entre los años 1990 y 2010 / Prevalence of odontogenic cysts: Hospital Regional Valdivia, between years 1990-2010

    Scientific Electronic Library Online (English)

    F.I., Peters; G.P., López; E.G., Preisler; C.C., Sotomayor; Z.M., Donoso; V.S., Hernández.

    2012-12-01

    Full Text Available Objetivo: Determinar la prevalencia de quistes odontogénicos en población atendida en el Hospital Regional Valdivia, en el periodo entre 1990-2010, según la última clasificación de lesiones quísticas de la Organización Mundial de la Salud (OMS), 2005. Esta investigación corresponde a un estudio desc [...] riptivo de corte transversal censal. Metodología: Se revisaron informes de biopsias del Hospital Regional Valdivia (HRV), durante un periodo de 20 años (1990-2010),seleccionando los informes con diagnósticos histopatológicos de quistes odontogénicos. Las variables a analizar fueron: año de emisión del informe, género y edad del paciente, localización anatómica de la lesión, diagnóstico histopatológico. Los datos se almacenaron en planilla de base de datos para su análisis estadístico. Resultados: De las 1.850 biopsias del territorio maxilofacial evaluadas, la prevalencia de Quistes Odontogénicos alcanzó un 11,9%. Según tipo de quiste, los más prevalente fueron el quiste radicular (84,5%), quiste dentígero (14,1%) y quiste residual (0,9%). El de menor prevalencia fue el quiste de erupción (0,5%). Un 52,7% del total de quistes odontogénicos correspondieron al género femenino. El rango de edad de presentación va entre los 4 y los 81 años (promedio 31,7±3,7 años). El área anatómica más afectada es el maxilar superior con 65,5%. Conclusión: Los Quistes odontogénicos son entidades diagnosticadas histopatológicamente en forma variable durante el periodo de tiempo comprendido entre los años 1990 y 2010, en el HRV. Se presentan en mayor frecuencia en mujeres, sin predilección por género, afectando principalmente a la 3ª década de vida. La entidad quística mas prevalente fue el quiste radicular. Abstract in english Objective: Determine the prevalence of Odontological Cysts in the attended patients of Hospital Regional Valdivia, between 1990 and 2010, according to the World Health Organization (WHO) classification of tumour like lesions, 2005. This investigation corresponds to a descriptive cross-sectional stud [...] y. Method: The biopsy reports of the Hospital Regional Valdivia, during a 20 years period (1990-2010), were analyzed, selecting those with Odontological Cysts histopathological diagnosis. The analyzed variables were: year of the biopsy report; patient's gender and age; anatomical location of the lesion and histopathological diagnosis. The extracted data were stored in a data base for descriptive statistical analysis. Results: Within the 1850 biopsies found from the maxilofacial region, the Odontological Cysts prevalence was 11.9%. According to the type of cyst, the most prevalent was Radicular/Periapical Cyst (84.5%), followed by Dentigerous/Folicular Cyst (14.1%), and then Residual Cyst (0.9%). The least prevalent was Eruption Cyst (0.5%). 52.7% of all Odontological Cystswere found in women. The cysts's presentation among age ranges was between 4 and 81 years old (average 31.7±3.7 years old). The most frequently affected anatomical region was the superior maxilla (65.5%). Conclusion: Odontological Cysts are histopathologically diagnosed lesions in varying ways between 1990 and 2010 at Hospital Regional Valdivia. Without gender predilection, they present most commonly affecting women, mainly those in the 3rd decade of life. The most common cystic lesion found was Radicular/Periapical Cyst.

  14. Anodoncia parcial relacionada con Quiste Dentígero y Quiste Traumático. revisión de la literatura y presentación de un caso / PARTIAL ANODONTIA RELATED TO DENTIGEROUS CYST AND TRAUMATIC CYST. REVIEW OF THE LITERATURE AND PRESENTATION OF A CASE.

    Scientific Electronic Library Online (English)

    Yuli, Moret; José María, González.

    2003-08-01

    Full Text Available Resumen La Anodoncia parcial es una anomalía de número caracterizada por la ausencia congénita de dientes primarios y permanentes. Se ha designado con otros términos como agenesia dental, oligodoncia e Hipodoncia. Se presenta un caso de una niña afectada por esta enfermedad teniendo en cuenta que es [...] un caso aislado sin otros rasgos de patología genética sindromática y que a la vez estaba relacionado con dos patologías: quiste Traumático y quiste Dentígero. Se planificó tratamiento combinado: quirúrgico y toma de muestra para estudio histopatológico, ortodoncia, prótesis. Evaluaciones periódicas. Abstract in english Abstract Partial anodontia is an abnormality of number characterized by the congenital absence of primary and permanent teeth. It has been designated by other names such as dental agenesia, oligodoncy, and hypodoncy. We present the case of a male child with this disease, bearing in mind that this is [...] an isolate case with no other elements of syndromatic genetic pathology, and that it was also related to two other pathologies: Traumatic Cyst and Dentigerous Cyst. A combined treatment involving surgery and sampling for histopathological study, orthodoncy, and prosthesis was planned, calling for periodic evaluations.

  15. Testis Sparing Surgery For Epidermoid Cyst of Testis in an Infertile Man

    Directory of Open Access Journals (Sweden)

    Parlakta?, B., S.

    2005-01-01

    Full Text Available In this case report, testis sparing surgery, performed for a heterogenous testicular mass in a 25 year-old man was presented. The patient was infertile for five years. Preoperative ultrasound findings allowed us to such surgery. Intraoperative frozen sectioning showed the benign nature of the lesion, consistent with the final histologic examination. For aesthetic, cosmetic, psychologic and fertility preserving benefits, treatment selection of testis sparing surgery in some testicular masses should be carried out according to clinical, radiological and frozen section findings.

  16. FGF2 mediates DNA repair in epidermoid carcinoma cells exposed to ionizing radiation

    International Nuclear Information System (INIS)

    Fibroblast growth factor 2 (FGF2) is a well-known survival factor. However, its role in DNA repair is poorly documented. The present study was designed to investigate in epidermoid carcinoma cells the potential role of FGF2 in DNA repair. The side population (SP) with cancer stem cell-like properties and the main population (MP) were isolated from human A431 squamous carcinoma cells. Radiation-induced DNA damage and repair were assessed using the alkaline comet assay. FGF2 expression was quantified by enzyme linked immunosorbent assay (ELISA). SP cells exhibited rapid repair of radiation induced DNA damage and a high constitutive level of nuclear FGF2. Blocking FGF2 signaling abrogated the rapid DNA repair. In contrast, in MP cells, a slower repair of damage was associated with low basal expression of FGF2. Moreover, the addition of exogenous FGF2 accelerated DNA repair in MP cells. When irradiated, SP cells secreted FGF2, whereas MP cells did not. FGF2 was found to mediate DNA repair in epidermoid carcinoma cells. We postulate that carcinoma stem cells would be intrinsically primed to rapidly repair DNA damage by a high constitutive level of nuclear FGF2. In contrast, the main population with a low FGF2 content exhibits a lower repair rate which can be increased by exogenous FGF2. (authors)

  17. Ultrasonographic diagnosis of torsion of testicular appendages

    International Nuclear Information System (INIS)

    To determine the efficacy of ultrasound in boys presenting torsion of a testicular appendage. A series of 30 boys with acute scrotal pain due to torsion of a testicular appendage was studied. Nine patients underwent surgery. The clinical findings and course in the remaining 21 suggested the presence of this abnormality. All of them underwent conventional and color Doppler ultrasound using a 7.5 MHz transducer. In 15 boys, ultrasound images depicted the affected appendage as a mass between the epididymal head and the testicle. In 13 cases, only signs of a inflammatory reaction, with enlargement of the epididymal head and tunicas presenting hyperflow and hydrocele, mimicking acute epididymities. In two cases, the images were normal. There is no definitive, distinguishing ultrasound image corresponding to testicular appendage torsion. Therefore, this diagnostic technique should be accompanied by clinical assessment. (Author) 14 refs

  18. Quiste gigante de ovario en una adolescente: presentación de un caso Giant ovarian cyst in an adolescent: a case report

    Directory of Open Access Journals (Sweden)

    Olimpia Contreras Leal

    2009-06-01

    Full Text Available Se trata de una adolescente de 13 años de edad con antecedentes de salud con menarquía a los 11 años y metrorragias frecuentes que acudió a consulta de Pediatría del Hospital Regional de Bata Litoral en la República de Guinea Ecuatorial por aumento de volumen del abdomen, específicamente del hemiabdomen derecho, es ínter consultada con Ginecología por sospecha de tumor de ovario, lo cual se corroboró por ultrasonografía. Se realiza intervención quirúrgica encontrándose quiste gigante de ovario derecho que pesó 6 kg del cual no tuvimos el diagnóstico histológico por no disponer de laboratorio de Anatomía Patológica, pero por las características macroscópicas se trató como un Quiste Seroso Simple, La paciente tuvo una evolución favorable.A 13- year-old girl is presented, having undergone a good health and menarche at 11 years old, she has had vaginal bleeding frequently, and came to Pediatrics Clinics at Bata Littoral Provincial Hospital in Equatorial Guinea with the Pediatrician. The main symptoms were abdominal volume increase, more specifically at right hemiabdomen and pain to deep palpation. This case was sent to the Gynecologist and an ovarian tumor was suspected, afterwards verified by the ultrasonographic study. The patients was referred to surgery, the final clinical diagnosis was Right Ovary Giant Cyst, weighing 6 kg. The histological diagnosis was not assessed because the lack of pathology lab in this country. Following the macroscopic features the tumor was treated as a Simple Serous Cyst. The patient had a favorable evolution.

  19. Isolated relapse ganglions of epidermoid carcinomas of superior aero-digestive ways:Does the brachytherapy have its place

    International Nuclear Information System (INIS)

    The brachytherapy of isolated ganglions relapses of epidermoid carcinomas allows the ganglions control to three years in 25% of cases. Taking into account its toxicity (6% of deceases) and the unfavorable prognosis of the illness, a cervical ganglion surgery must be always preferred. (N.C.)

  20. Unusual coexistence of an epidermoid cyst with an atypical meningioma: Case report and review of the literature

    Science.gov (United States)

    Karekezi, Claire; El Fatemi, Nizare; Egu, Komi; Ibrahimi, Mohamed; El Maaqili, Moulay Rachid; El Abbadi, Najia

    2016-01-01

    Background: Coexistence of multiple primary intracranial tumors of different cell types has rarely been documented; the association of a meningioma and a glioma has been reported as the most common combination. Hereby, we report an unusual case of a temporal epidermoid cyst coexisting with an atypical meningioma. Case Presentation: A 37-year-old male presented with progressive symptoms of raised intracranial progression with progressive loss of vision without any neurological deficit. On admission, magnetic resonance imaging (MRI) revealed a right frontal lesion appearing hypointense T1, hyperintense T2 slightly enhanced after gadolinium and a second right temporal, isointense T1, hyperintense T2 non-enhancing lesion. A right frontotemporal craniotomy was performed that revealed two distinct lesions: The whitish temporal lesion with the pearl appearance reminding of an epidermoid cyst, the second lesion was extraaxial fibrous lesion arising from the falx. Pathology confirmed an atypical meningioma WHO Grade II and an epidermoid cyst. Conclusion: The simultaneous occurrence of primary intracranial tumors of different cell types is rare. Epidermoid cysts are slow growing lesions believed to arise from inclusion of ectodermal elements during neural tube closure, while meningiomas arise from arachnoidal cells; their association has rarely been reported previously. PMID:27069741

  1. Quiste hidatídico retro-peritoneal: Una enfermedad frecuente en una ubicación inusual Retroperitoneal hydatid cyst: A common disease in a rare location

    Directory of Open Access Journals (Sweden)

    Stephanie Subercaseaux V

    2010-12-01

    Full Text Available La hidatidosis sigue siendo un problema prevalente en áreas endémicas. Presentamos el caso de un quiste hidatídico primario ubicado en el espacio retro-peritoneal. Mujer de 54 años, procedente de área rural del sur de Chile, hospitalizada por cuadro de coxalgia derecha y aumento de volumen glúteo, con tres meses de evolución. Se realizó el diagnóstico de hidatidosis complicada por medio de exámenes de imágenes, tests serológicos y anatomía patológica. No se demostraron quistes hidatídicos en otras ubicaciones. Se realizó un drenaje percutáneo del quiste infectado y se administraron antihelmínticos durante 12 semanas y actualmente permanece en seguimiento cercano con buena respuesta al tratamiento. El quiste hidatídico debe ser considerado en el diagnóstico diferencial de masas quísticas retro-peritoneales, especialmente en áreas endémicas.Echinococcal disease remains a major problem within some endemic areas. We report a case of a single primary echinococcal cyst located in the retroperitoneal space. A 54-year-old woman, born in a rural area of southern Chile, was admitted with a 3-month history of right hip pain and painful swelling of the gluteal region. Hidatid disease was confirmed with serologic test, radiological examinations and histo-pathology. There were no cysts in any other location. A percutaneous drainage was performed and antihelminthics were administered for 12 weeks and is now being closely followed up, with good response to therapy. Especially in the endemic areas hydatid cyst should be considered when evaluating retroperitoneal cystic masses.

  2. Dopplex Sonographic Evaluation of Variococele–Related Testicular Atrophy

    Directory of Open Access Journals (Sweden)

    A. Shakeri Bavil

    2007-10-01

    Full Text Available Introduction & Objective: Varicocele is often mentioned as a common cause of testicular atrophy. The aim of this study was to evaluate varicocele-related testicular atrophy with Duplex sonography.Materials & Methods: Seventeen patients with testicular atrophy due to varicocele were included into the study.Results: Echogenisity of the atrophic testis was homogeneous. Mean peak systolic velocities (PSV in intratesticular arteries for atrophic and normal testes were 5.57±2.03 cm/s and 6.49 ± 1.37 cm/s, respectively. The difference was not significant (P > 0.05.Conclusion: Varicocele-related testicular atrophy is not associated with testicular parenchymal heterogeneity, and does not affect the intra-testicular and testicular arterial PSV.

  3. Prognostic role of p53 protein expression in epidermoid carcinoma of the anal canal

    International Nuclear Information System (INIS)

    Purpose: To assess the prognostic significance of p53 protein expression in patients with primary epidermoid carcinoma of the anal canal managed by radiation therapy (XRT), 5-fluorouracil (5-FU), and mitomycin C (MMC). Methods and Materials: From January 1991 to December 1993, 58 consecutive patients with primary epidermoid carcinoma of the anal canal were treated in a prospectively designed protocol of XRT (24 Gy/12--3((1)/(2)) wk split--28 Gy/14) and concurrent 5-FU (1000 mg/m2/day 1-4) and MMC (10 mg/m2 day 1) of each cycle of XRT. Paraffin-embedded tumor samples were unavailable in 9 patients, leaving 49 patients in the study. Expression of p53 protein was studied using immunohistochemistry and quantified as percent tumor nuclei showing positive staining. Actuarial survival and disease-free survival (DFS) rates were estimated by the Kaplan-Meier method, and compared using the log-rank test. A Cox proportional hazard model was used for the multivariable analysis. Results: There were 6 T1, 26 T2, 7 T3, and 10 T4 lesions. Primary tumor sizes ranged from 1-15 cm with a median of 4 cm. There were 6 patients with nodal metastases. Median follow-up was 4.5 years. Positive nuclear immunostaining for p53 was observed in 40 of 49 patients. The median percent positive staining was 5%, with 13, 9, and 18 patients showing staining in <5%, 5 to <10%, and 10-50% of tumor nuclei respectively. There was no correlation of percent p53 staining with gender, age, tumor stage, size, or histology. Local, regional, and distant failures were observed in 12, 2, and 2 patients respectively. The 5-yr survival and DFS were 84% and 64% respectively. In univariate analysis, the only prognostic variable for survival was gender. For DFS, advanced T category and large tumor size were predictive of poor DFS. In multivariate analysis, poor DFS was associated with high T category (p = 0.0008), basaloid histology (p = 0.001), male gender (p = 0.002), and increasing percent of p53 protein expression (p 0.01). Conclusions: It is concluded that expression for p53 protein is present in a high percentage of patients with epidermoid carcinoma of the anal canal. For patients managed with combined XRT, 5-FU, and MMC, percent p53 protein expression is of prognostic value for DFS independent of other clinical factors such as T category, gender, and histology

  4. Simultaneous acute appendicitis with right testicular torsion

    Directory of Open Access Journals (Sweden)

    Tanveer Akhtar

    2012-01-01

    Full Text Available We present a child with both acute appendicitis and torsion of the right testis presenting at the same time. Testicular torsion possibly occurring due to vomiting in acute appendicitis so far has not been reported in the literature.

  5. Surgical treatment of testicular germinative tumors

    International Nuclear Information System (INIS)

    A critical appraisal of the role of surgery in the strategy of management of patients with germ cell testicular cancer is presented. Special interest is directed to treatment of the primary tumor and the importance of surgery after chemotherapy in patients with advanced disease. A critical discussion on the role of retroperitoneal lymphadenectomy in patients with nonseminomatous tumors is presented. (author)

  6. Testicular dysgenesis syndrome and Leydig cell function

    DEFF Research Database (Denmark)

    Joensen, Ulla Nordström; Jørgensen, Niels; Rajpert-De Meyts, Ewa; Skakkebaek, Niels Erik

    2008-01-01

    originating in early foetal life. TDS comprises various aspects of impaired gonadal development and function, including testicular cancer. A growing body of evidence, including animal models and research in human beings, points to lifestyle factors and endocrine disrupters as risk factors for TDS. We present...

  7. Testicular function in boys after chemotherapy and/or testicular irradiation for acute leukemia and malignant lymphoma

    International Nuclear Information System (INIS)

    Testicular function was investigated by testicular biopsy, testicular volume, testosterone and LH-RH test in 16 prepubertal boys with 15 cases of acute leukemia and one case of malignant lymphoma after chemotherapy and/or testicular irradiation. One of 2 cases who had infiltrated in testes received irradiation at onset. With another 2 cases, testis was resected at testicular relapse and irradiated on opposite side. All continued complete remission for 1-9 years after cessation of chemotherapy. Basal levels of serum testosterone, FSH and LH were normal in 13 cases of unirradiated group recently but spermatogonia in testicular biopsy specimen decreased on cessation of chemotherapy in 8 cases. Primary gonadal dysfunction was detected in 3 cases of irradiated group. And so testicular irradiation induced damage of tubular system and Leydig cell function. It is necessary to follow up about sexual maturation. (author)

  8. The Correlation between Ultrasound Testicular Volume and Conventional Semen Parameters in Albanian Subfertile Males

    Directory of Open Access Journals (Sweden)

    Adrian Kristo

    2014-09-01

    CONCLUSION: Testicular volume has a direct correlation with semen parameters and the critical total testicular volume indicating normal testicular function is approximately 26.6 ml (the mean testicular volume 13.3 ml. The measurement of testicular volume can be helpful for assessing fertility at the initial physical examination.

  9. Differentiation of testicular diseases via dynamic MRT

    International Nuclear Information System (INIS)

    The present study aimed at resolving whether dynamic MRT can improve diagnostic relevance in diseases of the testes compared with conventional spin echo images. The testes of 20 healthy volunteers and of 16 patients of the Department of Urology of the University of Bonn were examined by means of MR tomography. Within 12 hours after MR tomography the patients were surgically explored, biopsied and if necessary orchiectomised. Results obtained with the volunteers were uniform and well reproducible, independent of external influences. On comparing the maximal enhancement curves of the examined various testicular tumors with the standard values established by examining the healthy volunteers, the curves obtained with the malignant testicular tumors were always clearly above the chosen confidence range of 3 standard deviations so that malignancy diagnosis was easy. However, the degree of maximal enhancement did not enable us to arrive at a conclusion in respect of the tumor type or the degree of malignancy. The greatest enhancement occurred with the tumor of Sertoli's cell which could thus be clearly differentiated against the other malignant testicular tumors. Due to masking of the gadolinium effect by haemosiderin deposits, haemorrhagica in the tumor tissue should be excluded by means of T2-weighted spin echo sequences before following up a suspicion of malignant testicular tomor. Benign intratesticular changes could be safely separated from malignant findings by means of the maximal enhancement curve lying in the normal range or below the curve of the volunteers. As with other organs, dynamic MR tomography yields definitely more and better information than conventional MR tomography also in the diagnosis of testicular tumours. However, these ''pros'' do not offset the ''cons'' of high costs of such examinations. (orig.)

  10. Testicular cancer and HPV semen infection.

    Science.gov (United States)

    Garolla, Andrea; Pizzol, Damiano; Bertoldo, Alessandro; Ghezzi, Marco; Carraro, Umberto; Ferlin, Alberto; Foresta, Carlo

    2012-01-01

    Testicular cancer represents the more frequent solid tumor affecting males aged 15-35 years. In the last decades, its incidence showed a progressive increased probably due to genetic and environmental factors. Despite exposure to some viruses such as HIV, HCV, EBV, and HPV is frequently related to cancer development, there are no studies aimed to evaluate the possible implication of viral infections in the pathogenesis of testicular cancer. In this study, we analyzed sperm parameters and prevalence of HPV on sperm in 155 testicular cancer patients at diagnosis (T-1), after orchiectomy (T0) and after 12 months from surgery or from the end of adjuvant treatments (T12). All patients showed a significantly higher prevalence of semen infection than controls (9.5% and 2.4% respectively,) and altered sperm parameters both at T-1 and T0. Considering sperm parameters, at T-1 we observed a reduction of progressive motility, and after orchiectomy patients showed a reduction of sperm concentration and count and a further worsening of motility. Thereafter, patients were assigned to three groups on the basis of medical option after surgery: S = surveillance, R = radiotherapy, and C = chemotherapy +/- radiotherapy. At T12, untreated patients had an improvement of sperm parameters while R group and even more C group had a strong decrease of sperm number (p < 0.01 both vs. T0 and S group). Moreover, patients who received radio and/or chemotherapy had a very high prevalence of HPV semen infection (S = 7.7%, R = 30.8%, and C = 61.5%). In conclusion, patients with testicular cancer had frequently altered sperm parameters and higher prevalence of HPV semen infection that were worsened after radio and chemotherapy. Because HPV infection is a risk factor for cancer development and it may further reduce fertility, we suggest screening for HPV in testicular cancer patients at diagnosis and particularly after adjuvant treatments. PMID:23267350

  11. Pheophorbide a mediated photodynamic therapy against human epidermoid carcinoma cells (A431)

    Science.gov (United States)

    Chen, Yi-Chun; Li, Wen-Tyng

    2011-02-01

    The objective of this study was to characterize the death mechanism of human epidermoid carcinoma cells (A431) triggered by photodynamic therapy (PDT) with pheophorbide a. First of all, significant inhibition on the survival of A431 cells (N-Acetyl cysteine prevented ROS production and increased cell survival thereafter. The decrease in cellular ATP level was also observed at 6 hrs after PDT. Typical apoptotic cellular morphology and a collapse of mitochondrial membrane potential occurred after PDT. The loss of mitochondrial membrane potential led to the release of cytochrome c from the mitochondria to the cytosol, followed by activation of caspase-9 and caspase-3. The activation of caspase-3 resulted in poly(ADP-ribose) polymerase (PARP) cleavage in A431 cells, followed by DNA fragmentation. In conclusion, the results demonstrated that pheophorbide a possessed photodynamic action against A431 cells, mainly through apoptosis mediated by mitochondrial intrinsic pathway triggered by ROS.

  12. Pulmonary epidermoid carcinoma in a patient with acromegaly: a rare entity.

    Science.gov (United States)

    El Aziz, Siham; Chadli, Asma; Obbiba, Atika; El Ghomari, Hassan; Farouqi, Ahmed

    2012-01-01

    A 56-years-old woman was referred to our unit for partially treated acromegaly. She had a high level of insulin growth factor. She did not complain of any pulmonary symptoms and was a non-smoker. Physical examination revealed clinical features of acromegaly. She had a 13 mm pituitary adenoma and was proposed for surgical intervention. Her chest X-ray showed a right paracardiac tumor. Computed tomography scan revealed a large right-sided fowler tumor. Pituitary surgery was cancelled and lobectomy after biopsy with lymph nodes excision was performed through thoracotomy. Histological study of the tumor revealed a medium differentiated epidermoid carcinoma with positive lymph nodes and extension to pleura. She was referred to chemotherapy protocol. Association between carcinoma and acromegaly has previously been reported. Most common tumors are colorectal and thyroid neoplasia. As we see in this case report, we need to consider other carcinomas in acromegalic patients like pulmonary carcinoma, despite their rarity in women. PMID:22891085

  13. Proliferating cell nuclear antigen PCNA expression in lung epidermoid carcinoma LL tissues after photosensitized tumour therapy

    International Nuclear Information System (INIS)

    Cell proliferation associated markers are known to serve as an important attributes of tumour biologic characteristic and its response to treatment. The study was undertaken to perform immunohistochemical analysis of expression of one of the main cell proliferation associated markers -proliferating cell nuclear antigen PCNA, in histological specimens of experimental tumours obtained after photosensitized tumour therapy (PTT) or combination of PTT with adriamycin and to evaluate tumour stress response to treatment. Immunomorphological investigation of lung epidermoid carcinoma LL revealed heterogeneity in morphological patterns of treatment-induced cell death. Data obtained show that PCNA expression in tumour cell induced by treatment with PTT or PTT combination with adriuamycin could be linked to cell proliferation and repair processes as well as to triggering of cell death execution. (author)

  14. Inguinal sentinel node biopsy in epidermoid carcinoma of the anal canal: a pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Leonaldson Santos; Mali Junior, Jorge; Rezende Neto, Jose Francisco; Pedras, Dauro de Sa Villela; Stoduto, Gustavo; Pacheco, Jairo Sousa; Valadao, Marcus; Correa, Jose Humberto Simoes; Dias, Jurandir de Almeida [Instituto Nacional do Cancer (INCa), Rio de Janeiro, RJ (Brazil). Servico de Medicina Nuclear; Instituto Nacional do Cancer (INCa), Rio de Janeiro, RJ (Brazil). Servico de Cirurgia Pelvico-Abdominal]. E-mail: leonaldson@uol.com.br

    2005-04-15

    It has been well established that the primary therapeutic approach to anal squamous-cell carcinoma is chemoradiotherapy. Inguinal lymph node (LN) status is an important prognosis indicator and the presence of metastases in the inguinal LN is an independent marker of the local failure and overall survival. The appropriate management of patients with primary anal cancer and clinically uninvolved groins remains controversial. Nowadays there is no reliable diagnostic method to accurately determine nodal status of the inguinal region. This study was conducted to evaluate the feasibility of a novel assessment method of the nodal status of the inguinal region in patients with epidermoid carcinoma of the anus and anal margin. We advocate that sentinel lymph node biopsy is a safe and feasible technique to detect metastases in inguinal nodes. (author)

  15. [Laryngeal epidermoid carcinoma in a young adult without risk factors: a case report].

    Science.gov (United States)

    M'barek, Basma; Gargouri, W; Maalej, M

    2005-08-01

    Head and neck carcinomas are rare in young patients without a history of tobacco consution, tho two classical risk factors. Our report is about 20 year-old patient without a history exosure to radiations or of alcohol / tobacco consumption, who presented with repeated episodes of dysphonia that didn't improve under medical treatment. Endoscopy showed a fungating hemilaryngeal lesion with a histology of epidermoid carcinoma stage T3N0. The patient initially 3 courses of cisplatin-5 fluorouracil resulting in a 90% objective response, followed by a loco-regional radiotherapy. 36 months after the diagnosis and 24 after the end of therapy, the patient is still alive and in complete remission. PMID:16238282

  16. Interstitial brachytherapy in the treatment of oropharyngeal epidermoid carcinomas (256 pts)

    International Nuclear Information System (INIS)

    Purpose: the objective of this study is to report the results of interstitial brachytherapy [BT] used as exclusive treatment or as a boost in a large series of velo-tonsillar or glosso-tonsillar epidermoid carcinomas. Materials and methods: from 1982 to 1995, 256 patients (230 men and 26 women; average age: 60 years), with oropharyngeal epidermoid cancer as described above have been treated with 192 Iridium LDR interstitial BT: 218 primary tumors [PT] (39 T1, 103 T2, 74 T3, 2 T4) and 38 second primary tumors [SPT] developed in previously irradiated area (24 T1, 8 T2, 6 T3). Most of these lesions were ulcerated or infiltrating (79%). Treatment of PT associated external beam irradiation (mean dose: 52 Gy) and interstitial BT (15 to 25 Gy) with the plastic tube technique (1 to 4 radio - active wires). Lymphatic areas have been treated by exclusive irradiation, radical neck dissection and irradiation, or with irradiation followed by lymphadenectomy. SPT have been treated with BT alone (50 to 75 Gy; 25 case) or with external beam irradiation (30 to 50 Gy) and BT (15 to 40 Gy; 13 cases). No treatment has been performed for lymphatic areas (all patients NO). Results: Local control rate is similar for PT (84%) and for SPT (76%): 90 and 89% respectively for tonsillar tumors, 80 and 73% for palatin arch and 83 and 80% for glosso-tonsillar sulcus. The rate of grade 2 and 3 delayed toxicity is 10% for PT and 14% for SPT. The 3 years survival rates are respectively 71% for primary tumors and 46% for second primaries. Discussion: when compared with external beam RT, BT allows a local control rate increase of 10 to 25% with low complication rates. Salvage surgery morbidity is not increased and salivary function is partially preserved with improvement of quality of life

  17. Quistes de los maxilares en niños: Un analisis clínico / Cystic lesions of the jaws in children: A clinic analysis

    Scientific Electronic Library Online (English)

    Gustavo, Pina Godoy; Éricka Janine, Dantas da Silveira; Manuel Antonio, Gordón-Núñez; Lélia Maria, Guedes Queiroz; Daniela, Medeiros Dantas Gomes.

    2007-12-01

    Full Text Available Objetivo: Realizar uma avaliação epidemiológica dos cistos odontogênicos em pacientes de 0 a 14 años de edad, verificando quais são as lesões de mayor incidência entre estas idades. Métodos: Foram avaliadas 100 fichas histopatológicas de lesões diagnosticadas como cistos de natureza odontogênica, en [...] fatizando as características clínicas (gênero, idade, tipo de lesão cística, localização anatômica e tamanho da lesão) e radiográficas. Resultados: Foi observado que o gênero masculino, com idade média de 9,78 anos, assim como as regiões posterior de mandíbula e anterior da maxila foram mais comprometidos. O cisto dentígero foi a lesão mais comum, seguida d cisto radicular. Observou-se, além disso, que na amostra avaliada o aspecto radiográfico unilocular e as lesões assintomáticas foram as mais freqüentes. Conclusões: Foi concluído que é muito importante realizar este tipo de estudos, uma vez que, através deles podemos conhecer a freqüência e incidência de diversas lesões, principalmente em pacientes pediátricos, nos quais pouco se conhece sobre a prevalência das lesões císticas dos maxilares. Abstract in spanish Objetivo: Realizar una evaluación epidemiológica de los quistes odontogénicos en pacientes de 0 a 14 años de edad, verificando cuales son las lesiones de mayor incidencia entre estas edades. Métodos: Fueron evaluadas 100 fichas histopatológicas de lesiones diagnosticadas como quistes de naturaleza o [...] dontogénica, enfatizando las características clínicas (género, edad, tipo de lesión quística, localización anatómica y tamaño de la lesión) y radiográficas. Resultados: Fue observado que el género masculino, con edad media de 9,78 años, así como las regiones posterior de mandíbula y anterior de la maxila fueron más comprometidos. El quiste dentígero fue la lesión más común, seguida del quiste radicular. Se observó además, que en la muestra evaluada el aspecto radiográfico unilocular y las lesiones asintomáticas fueron las más frecuentes. Conclusiones: Se concluyó que es muy importante realizar éste tipo de estudios, una vez que, a través de ellos podemos conocer la frecuencia e incidencia de diversas lesiones, principalmente en pacientes pediátricos, en los cuales poco se conoce sobre la prevalencia de las lesiones quísticas de los maxilares. Abstract in english Objective: To realize an epidemiologic survey of odontogenic cysts in patients from 0 to 14 years old in order to find out the most prevalent lesions of each age period. Methods: 100 histopathologic files of lesions diagnosed as cysts of odontogenic origin were retrieved emphasing their clinic (cyst [...] ic lesion pattern, gender, age, anatomical site and lesion lenght) and radiographic features, which the surgical specimens were forwarded for the Oral Pathology Service of UFRN. Results: It could be identified that either the male gender, with an age average of 9,78 years, or the mandible posterior and the anterior maxilla region were more involved. Dentigerous cyst was the most prevalent lesions, followed by the radicular cyst. Moreover, a unilocular radiolucence and asymptomatic lesions were more common in the sample. Conclusions: To sum up, it can be infered the outstanding relevance of studies like the present since that it is through than that it can be reached the knownlodge of the frequence and incidence of several lesions, especially in paediatric patients inasmuch as the few knownlodge of the cystic lesion prevalence in their jaws.

  18. Neonatal outcome and congenital malformations in children born after ICSI with testicular or epididymal sperm

    DEFF Research Database (Denmark)

    Fedder, J; Loft, A; Parner, Erik Thorlund; Rasmussen, S; Pinborg, A

    2013-01-01

    Does neonatal outcome including congenital malformations in children born after ICSI with epididymal and testicular sperm [testicular sperm extraction (TESE)/percutaneous epididymal sperm aspiration (PESA)/testicular sperm aspiration (TESA) (TPT)] differ from neonatal outcome in children born after...

  19. Tratamiento quirúrgico de pacientes con quistes de inclusión epidérmica / Surgical treatment of patients with epidermal inclusion cysts

    Scientific Electronic Library Online (English)

    José Manuel, Díaz Fernández; Alejandro Francisco, Agüero Díaz; Manuel, Fonseca Labaut; Carlos Juan, Puig González; Anyi Lucía, Díaz Cardero.

    2014-06-01

    Full Text Available Se realizó un estudio prospectivo, longitudinal y aleatorizado de 29 pacientes con quiste de inclusión epidérmica en la región cervicofacial, no infectados, atendidos en el Servicio de Cirugía Maxilofacial del Hospital Clinicoquirúrgico Docente "Saturnino Lora Torres" de Santiago de Cuba, desde juni [...] o de 2011 hasta noviembre de 2012, tratados quirúrgicamente mediante los métodos de incisión lineal mínima o excisión en W, con vistas a comparar los resultados de ambos procederes. Se obtuvo que el tiempo operatorio promedio fue más corto en el grupo de incisión lineal mínima y que los quistes que medían entre menos de 1 y hasta 2 cm, localizados en las unidades estéticas faciales de mayor exigencia, eran mejor tratados con dicho método, lo cual produjo mejores resultados y un índice recurrencia no significativo en relación con la excisión en W Abstract in english A prospective, longitudinal and randomized study of 29 patients with epidermal inclusion cysts in the cervicofacial region, not infected, assisted in the Maxillofacial Surgery Service of "Saturnino Lora Torres" Teaching Clinical Surgical Hospital in Santiago de Cuba was carried out from June, 2011 t [...] o November, 2012, surgically treated by means of the methods of minimal lineal incision or W excision, with the aim of comparing the results of both procedures. It was obtained that the average surgical time was shorter in the group of minimal lineal incision and that the cysts fluctuating from less than 1 cm and up to 2 cm, located in the facial aesthetic units of greater demand, were better treated with this method, what produced better results and a non significant recurrence value in relation to the W excision

  20. Fibroma ameloblástico versus quiste folicular hiperplásico Ameloblastic fibroma versus hyperplastic follicular cyst

    Directory of Open Access Journals (Sweden)

    J. Azúa-Romeo

    2004-06-01

    Full Text Available Resumen: El fibroma ameloblástico (FA es un tumor odontogénico mixto, compuesto por tejido mesenquimal y epitelio odontogénico, representando el 2% de los tumores odontogénicos, mientras que el quiste dentígero o folicular (QF, el segundo quiste odontogénico en frecuencia, está compuesto exclusivamente por tejido conjuntivo laxo (mesénquima, si bien, el saco fibroso puede contener restos de epitelio odontogénico incluidos, dando lugar a una imagen histológica muy similar. La importancia de esta diferenciación radica en el tratamiento, que es ligeramente más agresivo en el FA y en el comportamiento biológico, ya que el FA puede derivar en un sarcoma ameloblástico, y el QF puede evolucionar hacia ameloblastoma y más raramente carcinoma mucoepidermoide.Abstract: Ameloblastic fibroma (AF is a mixed odontogenic tumor composed of mesenchymal tissue and odontogenic epithelium, accounting for 2% of all odontogenic tumors, while dentigerous or follicular cyst (FQ, second odontogenic cyst in frequency, is formed exclusivelly by soft conective tissue (mesenchyme. Nevertheless, hiperplastic fibrous sac may contain rests of odontogenic epithelium, showing a similar histologic pattern. The importance of an adequate differentiation lies in the treatment, which is slightly aggresive for AF, and regarding the biological behaviour of both lesions, since AF might become in an ameloblastic sarcoma, while over an FQ could develope an ameloblastoma or even a mucoepidermoid carcinoma.

  1. Identificación de células proliferativas en quistes de Taenia solium / Identification of proliferating cells in Taenia solium cysts

    Scientific Electronic Library Online (English)

    Miguel Ángel, Orrego-Solano; Carla, Cangalaya; Theodore E, Nash; Cristina, Guerra-Giraldez.

    2014-10-01

    Full Text Available Los neoblastos son células totipotentes, únicas responsables de la proliferación y maduración de tejidos en platelmintos de vida libre. Células similares se han aislado en platelmintos parásitos como Echinococcus. Taenia solium causa la teniasis humana (intestinal) y la cisticercosis en humanos y ce [...] rdos. La infección del cerebro con larvas (quistes) de T. solium resulta en neurocisticercosis, hiperendémica en el Perú; su tratamiento se asocia a síntomas neurológicos graves. La capacidad proliferativa y el desarrollo de los estadios de T. solium aún no se describen, y no se ha caracterizado los neoblastos de este parásito. Se buscó células proliferativas en quistes de T. solium colectados de un cerdo infectado, que fueron identificadas al replicarse e incorporar el nucleótido bromodesoxiuridina, detectado con un anticuerpo monoclonal. Una línea celular estable de neoblastos sería útil para estudios sistemáticos in vitro sobre eficacia de drogas y sobre la biología de T. solium. Abstract in english Neoblasts are totipotent cells, solely responsible for the proliferation and maturation of tissues in free-living flatworms. Similar cells have been isolated from parasitic flatworms such as Echinococcus. Taenia solium causes human taeniasis (intestinal) and cysticercosis in humans and pigs. Brain i [...] nfection with larvae (cysts) of T. solium results in neurocysticercosis which is hyperendemic in Peru, and its treatment is associated with serious neurological symptoms. The proliferative capacity and development stages of T. solium have not been described and the neoblasts of this parasite have not been characterized We looked for cell proliferation in T. solium cysts collected from an infected pig, which were identified when replicating and incorporating bromodeoxyuridine nucleotide detected with a monoclonal antibody. A stable cell line of neoblasts would be useful for systematic in vitro studies on drug efficacy and the biology of T. solium.

  2. Identificación de células proliferativas en quistes de Taenia solium / Identification of proliferating cells in Taenia solium cysts

    Scientific Electronic Library Online (English)

    Miguel Ángel, Orrego-Solano; Carla, Cangalaya; Theodore E., Nash; Cristina, Guerra-Giraldez.

    2014-12-01

    Full Text Available Los neoblastos son células totipotentes, únicas responsables de la proliferación y maduración de tejidos en platelmintos de vida libre. Células similares se han aislado en platelmintos parásitos como Echinococcus. Taenia solium causa la teniasis humana (intestinal) y la cisticercosis en humanos y ce [...] rdos. La infección del cerebro con larvas (quistes) de T. solium resulta en neurocisticercosis, hiperendémica en el Perú; su tratamiento se asocia a síntomas neurológicos graves. La capacidad proliferativa y el desarrollo de los estadios de T. solium aún no se describen, y no se ha caracterizado los neoblastos de este parásito. Se buscó células proliferativas en quistes de T. solium colectados de un cerdo infectado, que fueron identificadas al replicarse e incorporar el nucleótido bromodesoxiuridina, detectado con un anticuerpo monoclonal. Una línea celular estable de neoblastos sería útil para estudios sistemáticos in vitro sobre eficacia de drogas y sobre la biología de T. solium. Abstract in english Neoblasts are totipotent cells, solely responsible for the proliferation and maturation of tissues in free-living flatworms. Similar cells have been isolated from parasitic flatworms such as Echinococcus. Taenia solium causes human taeniasis (intestinal) and cysticercosis in humans and pigs. Brain i [...] nfection with larvae (cysts) of T. solium results in neurocysticercosis which is hyperendemic in Peru, and its treatment is associated with serious neurological symptoms. The proliferative capacity and development stages of T. solium have not been described and the neoblasts of this parasite have not been characterized We looked for cell proliferation in T. solium cysts collected from an infected pig, which were identified when replicating and incorporating bromodeoxyuridine nucleotide detected with a monoclonal antibody. A stable cell line of neoblasts would be useful for systematic in vitro studies on drug efficacy and the biology of T. solium.

  3. Testicular sperm retrieval at the time of bilateral radical orchiectomy

    Directory of Open Access Journals (Sweden)

    Nassir Anmar

    2009-01-01

    Full Text Available A new indication for testicular tissue cryopreservation is discussed here. We evaluate the feasibility of testicular sperm extraction during bilateral orchiectomy for testicular cancer. A 26-year-old man with a history of right orchidopexy presented with primary infertility. Tests revealed left varicocele and oligospermia. He underwent varicocelectomy but was lost to follow-up. Nine months later, he presented with right-sided solid testicular swelling. Ultrasound examination confirmed the finding of possible neoplasm and revealed contralateral intratesticular lesion. Since the patient turned azoospermic, no semen sample could be cryopreserved. Permanent histopathological sections revealed bilateral classical seminomas. On processing the fresh healthy looking specimen, normal-looking viable sperm were obtained. Future attempts at in-vitro fertilization with intracytoplasmic sperm injection should be possible. This method has been described in metachronous testicular cancer, but to our knowledge, we are the first to use it in synchronous bilateral testicular tumors.

  4. La linfadenectomía retroperitoneal para el cáncer testicular

    Directory of Open Access Journals (Sweden)

    Jaime Gutiérrez-Góngora

    2001-03-01

    Full Text Available Históricamente, los pacientes diagnosticados con enfermedad neoplásica testicular B (II han sido tratados con una disección primaria de ganglios retroperitoneales con la opción de aplicar quimioterapia adyuvante. Recientemente, varios autores han optado por la quimioterapia como tratamiento primario con la linfadenectomía retroperitoneal reservada para los pacientes que no lograban una remisión completa después del tratamiento con quimioterapia. El objetivo de este trabajo es definir por qué la linfadenectomía retroperitoneal (LR es realizada siempre en el Servicio de Urología del Hospital San Juan de Dios en el tratamiento del cáncer testicular de células germinales no seminomatosas estadio clínico A (I y B (II. Se presenta el sustento científico que avala esta práctica y se hace una breve reseña del estadiaje, del procedimiento quirúrgico utilizado.

  5. Testicular chloroma in a nonleukemic infant.

    Science.gov (United States)

    Armstrong, Michael B; Nafiu, Olubukola O; Valdez, Riccardo; Park, John M; Williams, James A; Wechsler, Daniel S

    2005-07-01

    Extramedullary myeloid cell tumors (EMCT) are localized collections of immature myeloid cells that occur outside of the bone marrow. Usually observed concurrently with bone marrow disease, EMCT also may occur in the absence of overt marrow leukemia. In this report, we describe an infant with a testicular mass that was identified as an EMCT after orchiectomy. Unlike the only previously reported case of infantile testicular chloroma, this patient did not exhibit bone marrow disease at diagnosis. Because systemic chemotherapy is considered to be superior to local control (surgery, radiation therapy), the patient was treated with intensively timed induction chemotherapy followed by 3 cycles of maintenance treatment (according to CCG protocol #2891) but no radiation therapy. The patient remains disease-free 18 months after diagnosis. PMID:16012331

  6. A Rare Complication of Brucellosis: Testicular Abscess

    Directory of Open Access Journals (Sweden)

    Ümit Gul

    2016-01-01

    Full Text Available Brucellosis is a zoonosis caused by Brucella species. Brucella epididymo-orchitis had been reported in up to 20% of patients with brucellosis. This case was a male patient who developed Brucella epidiymo-orchitis and testicular abscess. He had fever, arthralgia and his right epididymis and right testicle were enlarged and tender. Ultrasound evaluation showed hypertrophy of the right epididymis and testis and moreover hypoechoic area within the testis. Brucella serology was positive and the patient did not respond completely to treatment with streptomycin, doxycycline, and rifampicina. Unilateral orchidectomy was decided. In areas where brucella infection is endemic brucella epididymo-orchitis should be considered in the differential diagnosis. Effective and rapid treatment is important. It should be noted that these patients may develop testicular abscess.

  7. Tumores testiculares na infância

    OpenAIRE

    Cologna Adauto José; Martins Antonio Carlos Pereira; Tucci Jr Silvio; Suaid Haylton Jorge; Celini Fábia Martins; Paschoal Ricardo Mesquita; Paschoalin Edson Luis

    2003-01-01

    Trata-se de um artigo de revisão de tumores testiculares na infância que representam 1 a 2% dos tumores sólidos pediátricos. Os tumores germinativos representam 60 a 75% dos tumores testiculares pediátricos. Destes o mais comum é o tumor de saco vitelino cujo tratamento consiste na orquiectomia radical. Segue-se em freqüência o teratoma que na infância tem comportamento benigno e pode ser manejado com observação ou orquiectomia parcial. Os tumores de células de Leydig, e os de células de Sert...

  8. Prenatal and familial associations of testicular cancer.

    OpenAIRE

    Swerdlow, A. J.; Huttly, S R; Smith, P.G.

    1987-01-01

    In a case-control study of testis cancer 259 cases with testicular cancer, 238 controls treated at radiotherapy centres and 251 non-radiotherapy hospital in-patient controls were interviewed about some possible prenatal and familial risk factors for the tumour. For firstborn men, the risk of testis cancer increased significantly according to maternal age at the subject's birth, and this effect was most marked for seminoma. The association with maternal age was not apparent for cases other tha...

  9. Testicular tumors - clinical aspects and therapy

    International Nuclear Information System (INIS)

    In this study the author reports about classification, clinical experience, therapy and therapeutic results of testicular tumors on the basis of results given in literature and of own investigations performed at the Clinic and Policlinic for Radiotherapy at Wuerzburg. In total, 97 patients with testicular tumors were examined and their cases analysed. These patients had received radiotherapy between January 1, 1962 and December 31, 1979. The difficulties with the intended classification of testicular tumors and the advantages and disadvantages of the individual nomenclatures are described. Consideration of the affected age-groups showed that this disease concerns mainly younger males with a high life expectancy. The study depicts the relatively discrete symptoms and signs and the difficulties connected with clinical diagnosis. A more generous indication for the exposition of the testicles is demanded. Also the lymphatic drainage of the testicular region, the resulting paths of metastatic spread and the difficulties connected with the lymphographic detection of metastases are described. There are three therapeutic measures: surgical intervention, radiotherapy and cytostatic treatment. With seminomas mandatory semitestectomy and radiotherapy will suffice; with other affections than seminomas, semitestectomy shall be followed by a combined therapy comprising removal of lymphatic nodes and cytostatic treatment and not so much radiotherapy. The results of treatment given in literature are compared with the own results. This comparison revealed good success with treatment of seminomas. With non-seminomal affections exclusive radiotherapy appears to be insufficient. Therefore a combined therapy is postulated, which must be rendered possible by a good interdisciplinary cooperation of pathologists, urologists and radiologists. (orig.)

  10. Testicular descent: INSL3, testosterone, genes and the intrauterine milieu

    DEFF Research Database (Denmark)

    Bay, Katrine; Main, Katharina M; Toppari, Jorma; Skakkebæk, Niels E

    2011-01-01

    Complete testicular descent is a sign of, and a prerequisite for, normal testicular function in adult life. The process of testis descent is dependent on gubernacular growth and reorganization, which is regulated by the Leydig cell hormones insulin-like peptide 3 (INSL3) and testosterone. Investi......Complete testicular descent is a sign of, and a prerequisite for, normal testicular function in adult life. The process of testis descent is dependent on gubernacular growth and reorganization, which is regulated by the Leydig cell hormones insulin-like peptide 3 (INSL3) and testosterone...

  11. Histological and hormonal testicular changes in spinal cord patients.

    Science.gov (United States)

    Leriche, A; Berard, E; Vauzelle, J L; Minaire, P; Girard, R; Archimbaud, J P; Bourret, J

    1977-11-01

    Hormonal dosages and testicular biopsy are discussed in paraplegic patients of several neurological levels. There are no absolute biological criteria but histology showed slowing of spermatogenesis. PMID:593717

  12. A Rare Cause of Testicular Metastasis: Upper Tract Urothelial Carcinoma

    Science.gov (United States)

    Manav, Alper Nesip; Kazan, Ercan; Ertek, Mehmet Şirin; Amasyalı, Akın Soner; Çulhacı, Nil; Erol, Haluk

    2014-01-01

    Metastatic testicular cancers are rare. Primary tumor sources are prostate, lung, and gastrointestinal tract for metastatic testicular cancers. Metastasis of urothelial carcinoma (UC) to the testis is extremely rare. Two-thirds of upper tract urothelial carcinoma (UTUC) is of invasive stage at diagnosis and metastatic sites are the pelvic lymph nodes, liver, lung, and bone. We report a rare case of metastatic UTUC to the testis which has not been reported before, except one case in the literature. Testicular metastasis of UC should be considered in patients with hematuria and testicular swelling. PMID:25120937

  13. Doppler sonographic findings in testicular microlithiasis

    Directory of Open Access Journals (Sweden)

    Selim Serter

    2008-08-01

    Full Text Available OBJECTIVE: The aim of this prospective study was to compare the resistive index (RI values, which is a parameter of testicular parenchymal perfusion, in testicular microlithiasis (TM cases and normal cases. MATERIALS AND METHODS: 2179 volunteers, all healthy men (17-42 years of age from the Annual Army Reserve Officer Training Corps training camp were included in the study. A screening scrotal ultrasound was performed and all men diagnosed with TM underwent a scrotal Doppler ultrasonography scan (US. US examinations were performed for subjects with TM and without TM as a control group and RI was determined. RESULTS: 53 men with TM were identified in the 2179 US. Spectral Doppler examination was applied to 50 randomly selected cases (100 testicles without TM and 92 testicles with TM, 39 cases (78 testicles with bilateral and 14 cases with unilateral involvement. However, 48 normal testicles (17 bilateral and 14 unilateral and 47 testicles with TM (15 bilateral and 17 unilateral, 10 of which were cases with bilateral TM where flow from the centripetal artery could be obtained and analyzed were included in the statistical analysis for resistive indices. There was no significant difference regarding the RI and spectral examinations between subjects with and without TM. An interesting finding was the twinkling artifact observed in three cases. CONCLUSION: Microliths did not alter the RI values and thus had no influence on testicular perfusion on Doppler US examination.

  14. Testicular Histomorphometric Evaluation of Zebu Bull Breeds

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    Paulo Antônio Terrabuio Andreussi

    2014-12-01

    Full Text Available The objective of this study was to evaluate the quantitative histology and testicular biometrics in zebu bulls of different breeds. Testicular fragments of Nelore (n=10, Polled Nelore (n=6, Gir (n=5, Guzerat (n=5 and Tabapuã bulls (n=5 were used. The fragments were perfusion-fixed in Karnovsky solution, embedded in glycol methacrylate and stained with toluidine blue-1% sodium borate. The Nelore animals had a higher tubular volumetric proportion (85.2% and greater height of the seminiferous epithelium (73.2 µm than the Gir, Guzerat and Tabapuã breeds. The Nelore animals also had a higher volumetric proportion of Leydig cells (5.2% than the Guzerat and Tabapuã breeds. There was no significant difference for any of these parameters between the Nelore and Polled Nelore breeds. The gonadosomatic index, seminiferous tubule diameter, cross-sectional area of the seminiferous tubule and tubule length (total length and length per gram of testicular parenchyma did not vary among the breeds studied. The morphometric parameters evaluated suggested that the genetic selection applied to the Nelore and Polled Nelore breeds improved the efficiency of spermatogenesis in these breeders.

  15. Cryopreservation of canine ovarian and testicular fibroblasts.

    Science.gov (United States)

    Yu, Il-Jeoung; Leibo, S P; Songsasen, Nucharin; Dresser, Betsy L; Kim, In-Shik

    2009-01-01

    To derive a practical procedure to store canine somatic cells, fibroblasts isolated from testicular or ovarian tissues were cryopreserved in 1.2 M ethylene glycol or in 1.2 M dimethylsulfoxide prepared in Dulbecco's Modified Eagle Medium as cryoprotectants, and were frozen either in plastic straws or vials. Thawed cells were cultured for 24 hr at 38.5 degree C in a humidified atmosphere of 5 percent CO2 95 percent air, and then their membrane integrity was assayed with a double fluorescent stain, Fertilight. In addition, frozen-thawed fibroblasts were cultured for 4 days, and then their functional survival was measured after staining small colonies with trypan blue. After freezing and thawing, membrane integrity of testicular fibroblasts was 55-70 percent and functional survival ranged from 20-40 percent. With frozen-thawed ovarian cells, the average membrane integrity was 55-75 percent and the average functional survival was 35-40 percent. When frozen in ethylene glycol, functional survival of ovarian fibroblasts was significantly higher than that of testicular cells (P less than 0.05). These methods should prove useful to preserve cells collected from canids in the wild. PMID:19750243

  16. Comet assay on mice testicular cells

    Directory of Open Access Journals (Sweden)

    Anoop Kumar Sharma

    2015-05-01

    Full Text Available Heritable mutations may result in a variety of adverse outcomes including genetic disease in the offspring. In recent years the focus on germ cell mutagenicity has increased and the “Globally Harmonized System of Classification and Labelling of Chemicals (GHS” has published classification criteria for germ cell mutagens (Speit et al., 2009. The in vivo Comet assay is considered a useful tool for investigating germ cell genotoxicity. In the present study DNA strand breaks in testicular cells of mice were investigated. Different classes of chemicals were tested in order to evaluate the sensitivity of the comet assay in testicular cells. The chemicals included environmentally relevant substances such as Bisphenol A, PFOS and Tetrabrombisphenol A. Statistical power calculations will be presented to aid in the design of future Comet assay studies on testicular cells. Power curves were provided with different fold changes in % tail DNA, different number of cells scored and different number of gels (Hansen et al., 2014. An example is shown in Figure 1. A high throughput version of the Comet assay was used. Samples were scored with a fully automatic comet assay scoring system that provided faster scoring of randomly selected cells.

  17. Tratamiento quirúrgico conservador del quiste dentígero en pacientes pediátricos atendidos en el postgrado de cirugía bucal facultad de odontología de la UCV: Seguimiento a largo plazo

    Scientific Electronic Library Online (English)

    Sol C, Del Valle; José A, Cedeño; Raúl, García-Arocha; César, Guerrero.

    2007-09-01

    Full Text Available RESUMEN De acuerdo a numerosos autores el tratamiento para el quiste dentígero ha sido la eliminación total del quiste incluyendo el diente involucrado aunque si la lesión se presenta en pacientes jóvenes que están en período de erupción dentaria y las características clínicas y radiográficas sugier [...] en la presencia de un quiste dentígero, existe una alternativa de tratamiento la cual es la de mantener el diente permanente no erupcionado y enuclear completamente la lesión, siempre que se obtenga el diagnóstico definitivo histopatológico confirmatorio de quiste dentígero. Se realizó un estudio clínico en 12 pacientes de 7 a 16 años de edad con un promedio de 9,4 años, quienes fueron tratados en el Postgrado de Cirugía Bucal de la Facultad de Odontología de la Universidad Central de Venezuela (UCV). Todos los pacientes tenían las características clínicas y radiográficas similares a las del quiste dentígero, se encontraron 5 mujeres y 7 hombres, los cuales fueron sometidos a biopsia excisional, donde se les eliminó la lesión por completo, dejándoles el diente permanente no erupcionado. Las lesiones eran en la mandíbula y las imágenes radiolúcidas eran bien delimitadas al cuello dentario y menores a 2,5 cms. de diámetro. Los pacientes con quiste dentígero asociado a un tercer molar fueron excluídos del estudio. El estudio histopatológico fue confirmatorio de quiste dentígero para cada paciente y a cada uno se les realizó un seguimiento clínico y radiográfico periódico desde 2 meses hasta 7 años, con un intervalo aproximado de cada 6 meses. (1999-2006). No se encontraron imágenes radiolúcidas en ninguna de las radiografías post-quirúrgicas. Todos mostraron nueva formación ósea alrededor del diente involucrado y erupción completa de la dentición permanente. Tres(3) pacientes fueron seguidos por 7 años, cuatro(4) por 5 años, dos(2) por 3 años con 9 meses y tres(3) por 2 años y 6 meses. A dos(2) de los pacientes se les realizó tratamiento ortodóncico para corregir su maloclusión. Preservar el diente involucrado en un Quiste Dentígero al enuclear totalmente la lesión es una alternativa de procedimiento quirúrgico  con resultados clínicos y radiográficos predecibles y estables. Este tratamiento puede ser usado como un manejo quirúrgico conservador que permite la erupción normal de la dentición permanente. Éste estudio enfatiza la importancia del manejo multidisciplinario en equipo (Cirujano Bucal, Patólogo Bucal, Ortodoncista y Odontopediatra) y el control radiográfico postquirúrgico contínuo de los pacientes para asegurarnos de que no ha habido recidiva o la aparición de alguna nueva patología asociada Abstract in english ABSTRACT According to most authors the common treatment for the dentigerous cyst has been total elimination of the cyst including the tooth involved; however if the lesion is present in young patients during the eruption period, and the radiographic and clinical features are suggesting of dentigerou [...] s cyst, an alternative treatment is the maintenance of the permanent tooth and enucleation of the lesion alone, stating that ameloblastomatous changes or other odontogenic lesions have been ruled out after histopathological analysis, and a diagnosis of dentigerous cyst is confirmed. This study was conducted on 12 patients with an age range of 6 to 16 years with a mean age of 9.4 years that were treated at the Oral Surgery Postgraduate Department, Dental School, Central University of Venezuela. There were 5 females and 7 males. All lesions were mandibular and all of them were unilocular and well-defined radiolucencies measuring less than 2,5 cms in greatest diameter. All cases involved the coronal portion with cervical attachment of an unerupted permanent tooth. Third molars were excluded. Patients underwent surgery (excisional biopsy) of the cyst with preservation of the involved tooth. Histologic diagnosis of dentigerous cyst was confirmed in each case. Clinical and radiographic follow-up was performed at 6 months

  18. Quiste del colédoco como causa de dolor abdominal: revisión de un caso y bibliografía

    Directory of Open Access Journals (Sweden)

    Laura Arroyo Martínez

    2004-09-01

    Full Text Available El quiste del colédoco se define como la dilatación congénita o combinada del árbol biliar extrahepático (tipo más frecuente o intrahepático. La etiología no está aún determinada, pero existen tres teorías. Esta patología se observa en niños y adultos, predominantemente en mujeres. Pueden manifestarse anomalías en todo el sistema biliar, ya sea intra o extrahepático. Se clasifica en 5 tipos. Antes, el abordaje de dichos quistes era la cistoentero anastomosis, pero ahora se recomienda realizar una escisión completa del quiste, para disminuir el riesgo de malignidad y desarrollo de colangitis o pancreatitis recurrente. Aquí se presenta el caso de una mujer de 21 años con dolor abdominal, ictericia y una masa en el hipocondrío derecho, secundario a dicha patología, que fue sometida a una resección quirúrgica con anastomosis primaria. La evaluación anatomopatológica demostró una estructura quística de aspecto similar a una vesícula biliar, congestiva y pardusca, con inflamación crónica leve. Tuvo un postoperatorio satisfactorio y egresó con tratamiento antibiótico. El quiste coledociano debe considerarse en el diagnóstico diferencial de aquellos pacientes con dolor abdominal y masa en el cuadrante.

  19. Radiation therapy for epidermoid carcinoma of the anal canal, clinical and treatment factors associated with outcome

    International Nuclear Information System (INIS)

    Background and purpose: In recent years, treatment with combined chemotherapy and radiation has become the standard of care for epidermoid carcinoma of the anus. However, optimal radiotherapy techniques and doses are not well established. Materials and methods: During the period 1975-1997, 106 patients with epidermoid carcinoma of the anal canal underwent radiation therapy. Treatment policies evolved from radiation therapy alone or with surgery, to combined chemotherapy and radiation followed by surgery, to combined chemotherapy and radiation. Results: Overall 74% of patients were NED (no evidence of disease) at last follow-up. The most important clinical correlate with ultimate freedom from disease (includes the contribution of salvage surgery) was extent of disease. The 5-year ultimate freedom from disease was 87±5% for T1/T2N0, 78±10% for T3N0 (15% salvaged by surgery), and 43±10% for either T4N0 or any N+ lesions (P<0.001, Tarone-Ware). There was no difference between planned vs. expectant surgery (5-year ultimate NED: 67±11% planned surgery vs. 73±5% expectant surgery). The most important correlate with late toxicity was a history of major pelvic surgery (surgical vs. non-surgical group: P=0.013, Fisher's exact test, two-tailed summation). Thirty-three additional malignancies have been seen in 26 patients. The most common additional malignancies were gynecologic (nine cases), head and neck (six cases), and lung cancer (five cases). Conclusions: For T1/T2N0 disease, moderate doses of radiation combined with chemotherapy provided adequate treatment. T4N0 and N+ lesions are the most appropriate candidates for investigational protocols evaluating dose intensification. T3N0 tumors may also be appropriate for investigation; however, dose intensification may ultimately prove counterproductive if the cure rate is not improved and salvage surgery is rendered more difficult. The volume of irradiated small bowel should be minimized for patients who have a past history of major pelvic surgery or who (because of locally advanced tumors) may need salvage surgery in the future. Because of the occurrence of additional malignancy, patients with anal cancer should receive general oncologic screening in long-term follow-up

  20. Definitive radiation therapy for clinical stage N0-N1 epidermoid carcinoma of the lung

    International Nuclear Information System (INIS)

    From 1976 through 1989, 94 patients with epidermoid carcinoma of the lung without mediastinal nodal involvement were treated with definitive radiation therapy (RT) at Gunma University Hospital. All patients were treated with 10 MV X-rays and the mediastinum was treated in 86% of the patients. The total dose ranged from 60 Gy to 80 Gy with once-daily conventional fractionation. The actuarial two and five-year survival rates of the entire group were 44% and 22%, respectively, with a median survival time (MST) of 17 months. Patients with a performance status of 0-1 lived longer than those with a status of 2 or more (MST 22.5 vs. 12 months). The survival of 60 patients with T2 tumors was better than that of 24 patients with T3 tumors (MST 19 vs. 13.5 months). Forty-seven patients with tumors less than 5 cm in diameter had a two-year progression rate of 25%, in comparison with 39% for 47 patients with tumors greater than 5 cm. The survival difference between these two groups was statistically significant (p<0.01). Patients given a total dose of 80 Gy or over had only 20% local progression at the time of the last follow-up, but they had a lower long-term survival rate than those given a total dose of 60-74 Gy because of the development of pulmonary insufficiency after high-dose irradiation. There was no relapse in the field given 40 Gy or more to the mediastinum for prophylaxis in the patients with no evidence of primary progression. The actuarial five-year survival rates for the patients given 40 Gy or more to the mediastinum, and for the patients given less than 40 Gy were 32% and 9%, respectively. These was a statistically significant difference between these two survival curves, (p<0.05). Differences in survival did not depend on age, sex, or location of the primary tumor. These results should provide support for definitive RT to manage patients with medically inoperable or unresectable epidermoid carcinoma of the lung without mediastinal nodal involvement. (author)

  1. Quiste dentígero: diagnóstico y resolución de un caso. Revisión de la literatura / Dentigerous cyst: diagnosis and resolution of a case. A review of the literature

    Scientific Electronic Library Online (English)

    J., Vázquez Diego; C., Gandini Pablo; E., Carvajal Eduardo.

    2008-12-01

    Full Text Available Se presenta un caso clínico de quiste dentígero asociado a un segundo premolar inferior derecho retenido. El paciente de 13 años de edad es de sexo masculino. Se utilizan las técnicas radiográficas extraoral lateral oblicua de rama y la intraoral del paralelo para poder localizar y diagnosticar pres [...] untivamente dicha patología. Posteriormente se realiza la intervención quirúrgica para realizar la extracción del diente retenido y la enucleación del quiste el que es enviado para realizar los estudios anatomopatológicos los que corroboran el diagnóstico presuntivo. Se decide hacer seguimiento del caso. Basado en lo expuesto se analiza al quiste dentígero según ubicación, sexo, edad y maxilar; habiendo realizado una revisión de la literatura. Abstract in english A clinical case of dentigerous cyst associated with an impacted lower right second premolar in a 13-year-old male patient, is reported. An extraoral oblique lateral technique of the ramus and a parallel intraoral technique were used to locate the cyst and to perform a presumptive diagnosis of the le [...] sion. A surgical procedure was then carried out to remove the impacted tooth and also to enucleate the cyst, which was sent to the laboratory for a histo-pathological study; this study confirmed our earlier presumptive diagnosis. Finally, we decided to follow-up the case. Based on our findings, dentigerous cyst is analyzed according to its location, sex and age of patients and most affected jaw, after reviewing the literature on this subject.

  2. Quiste de Gorlin asociado a Odontoma: reporte de un caso con su tratamiento quirúrgico Gorlin cyst associated with odontoma: Case report with surgical treatment

    Directory of Open Access Journals (Sweden)

    P. Villarroel Castro

    2005-12-01

    Full Text Available El quiste de Gorlin es un quiste odontogénico que puede presentarse en dos variedades, una quística rodeada por epitelio y de carácter benigno, y una neoplásica localmente agresiva. Se presenta elcaso de una mujer de 18 años con aumento de volumen facial indoloro en región infraorbitaria izquierda. Se realiza la exéresis total de la lesión. Con el estudio histopatológico se obtiene el diagnóstico definitivo de quiste de Gorlin asociado a odontoma. Luego de controles por 3 años, se observa el restablecimiento de la simetría facial, una adecuada regeneración ósea y de los tejidos adyacentes, sin signos de recidiva.Gorlin cyst is an odontogenic cyst that may appear as two types, one cystic and surrounded by epithelium of a benign nature, and the other a locally aggressive neoplasm. The case is presented of an 18-year-old female that had experienced an increase in facial volume in the left infraorbital area that was painless. Total exeresis of the lesion was carried out. The histopathologic study provided the definitive diagnosis of Gorlin cyst associated with odontoma. After a follow-up of three years, facial symmetry was reestablished, there was adequate regeneration of bone and of the adjacent tissue, and there were no signs of relapse.

  3. A simple vitrification method for cryobanking avian testicular tissue

    Science.gov (United States)

    Cryopreservation of testicular tissue is a promising method of preserving male reproductive potential for avian species. This study was conducted to assess whether a vitrification method can be used to preserve avian testicular tissue, using the Japanese quail (Coturnix japonica) as a model. A sim...

  4. [Isolated testicular tuberculosis in children. Report of 2 Malagasy cases].

    Science.gov (United States)

    Rakototiana, A F; Hunald, F A; Razafimanjato, N; Ralahy, M F; Rakoto-Ratsimba, H N; Rantomalala, H Y H

    2009-02-01

    Isolated testicular tuberculosis is rare. The authors report 2 cases in children. The clinical features had no specificity: one case of hydrocele and 1 case of acute scrotum inflammation. Surgical exploration showed testicular nodules in both cases. Only histological examination provided the definitive diagnosis. The details of diagnosis and treatment are discussed and compared to the information available in the literature. PMID:19070998

  5. Detecção do Rearranjo da Proteína BCL2/JH em Carcinomas Epidermoides de Boca e Faringe

    Directory of Open Access Journals (Sweden)

    Montovani, Jair

    2010-09-01

    Full Text Available Introdução: A proteína BCL2 encontrada na membrana mitocondrial interna, regula a apoptose inibindo a morte celular programada. A translocação (14;18, detectada em 70 a 85% dos linfomas foliculares, leva a superexpressão da proteína BCL2, pela justaposição do gene BCL2 ao segmento JH do gene da cadeia pesada da imunoglobulina. Porém, os achados da expressão da BCL2 em carcinoma de cabeça e pescoço são contraditórios. Objetivo: Investigar a presença da translocação (14;18 do gene BCL2 em carcinomas de cabeça e pescoço. Método: Foram examinadas 16 amostras de DNA, sendo 13 de carcinomas de células escamosas (CCE e 3 de epidermoide (CE, por meio da reação em cadeia da polimerase (PCR. Resultados: O rearranjo BCL2/JH foi encontrado em 2 (15% dos 13 casos de CCE e em nenhum dos 3 casos de CE. A média de frequência de moléculas com rearranjo foi de 46,44 x 107. Não foi observada associação entre a presença de rearranjo e a exposição ao tabaco e álcool (p=0,6545. Conclusão: Diferente dos resultados encontrados em linfomas foliculares a presença da translocação (14;18 em carcinomas de cabeça e pescoço não é comum e, quando ocorre, pode ser uma mutação ocasional não associada a exposição ao tabaco e álcool.

  6. Detection of Protein BCL2/JH Rearrangement in Epidermoid Carcinomas of Mouth and Pharynx

    Directory of Open Access Journals (Sweden)

    Montovani, Jair

    2010-09-01

    Full Text Available Introduction: The BCL2 protein found in the internal mothocondrial membrana regulates the apoptosis preventing the programmed cell death. The translocation (14:18, detected in 70 to 85% of the follicular lymphoma, lead the super expression of BCL2 protein, by juxtaposition of BCL2 gene to the JH segment of the immunoglobulins' heavy chain gene. However, the found of the BCL2 expression in head and neck carcinoma are contradictious. Objective: To investigate the presence of the translocation (14:18 of the BCL2 gene in head and neck carcinoma. Method: Sixteen DNA samplers were examinated being 13 of squamous cells carcinoma (SCC and 3 of epidermoid (CE, y means of chain reaction of the polymerase (PCR. Results: The BCL2/JH rearrangement in 2 (15% of the CCE 13 cases and in none of the 3 cases of CE. The average of the frequency of molecules with rearrangement was 46,44x107. Was not observed association between the rearrangement presence and the exhibition to tobacco and alcohol (p=0, 6545. Conclusion: Different from the results found in follicular lymphoma, the presence of the translocation (14; 18 in head and neck carcinomas is not common and, when it occurs, it can be an occasional mutation not associated to exhibition to the tobacco and alcohol.

  7. Epidermoid cyst in the cerebellopontine angle cistern presenting as trigeminal neuralgia

    International Nuclear Information System (INIS)

    This 29-year-old male had been suffering from left trigeminal neuralgia one year prior to admission. Admission was prompted by the development of pain in the third division of the left trigeminal nerve. Physical and neurological examinations were not remarkable except for the facial pain. The orbicularis oculi reflex showed delayed latency of R1 on the affected side. CT scans performed pre- and post-contrast enhancement revealed a low density area in the left cerebellopontine angle cistern. Metrizamide CT cisternography clearly revealed the margin of the lesion as the contrast media did not enter into the low density area. A left suboccipital craniectomy was performed. The trigeminal nerve was surrounded by a thin-capsulated mass and cholesteatoma materials. Histological diagnosis was epidermoid cyst. Since this surgical procedure, the trigeminal neuralgia has not recurred for one year. Without objective neurological deficits, it is difficult to distinguish symptomatic trigeminal from idiopathic neuralgia. Therefore, minor change of the orbicularis oculi reflex should help in objectively detecting dysfunction of the trigeminal nerve. Metrizamide CT cisternography is also useful in diagnosis of cystic lesions. (author)

  8. Preoperative chemotherapy and radiotherapy in the managment of epidermoid carcinoma of the anal canal

    International Nuclear Information System (INIS)

    Sixteen patients affected by epidermoid carcinoma of the anal canal were treated preoperatively by means of an i.v. infusion of mitomycin C (15 mg/m2) on day 1 and 5-fluorouracil (750 mg/m2) days 1 to 5, followed by radiotherapy (3000 R in 3 weeks). Four to 6 weeks after the end of radiotherapy the response to the preoperative treatment was evaluated by means of biopsy. A reduction of the neoplastic mass was observed in 13 of the 16 patients. An evident correlation exists between the stage of the tumor and 1) the response to preoperative treatment 2) local recurrence, and 3) long-term survival. In fact: 3/4 T1 patients reached a complete response (CR), and 1/4 T1, 5/5 T2 and 4/7 T3 patients achieved a partial response (PR); only 3/7 T3 patients never responded to preoperative treatment. After the initial surgery, only T2 (3/5) and T3 (4/7) patients underwent a second operation for a recurrence. Overall survival at 42 months was 62.5% (T1, 100%; T2, 80%; T3, 28.5%)

  9. Phosphorylation of chloroform soluble compounds in plasma membranes of human epidermoid carcinoma A431 cells

    International Nuclear Information System (INIS)

    This study investigated a possible role for the epidermal growth factor (EGF) receptor protein tyrosine kinase in phosphoinositide metabolism with plasma membrane vesicles from human epidermoid carcinoma (A431) cells. The authors found a novel chloroform-soluble product radiolabeled with [gamma-32P]ATP that did not migrate from the origin in the thin layer system designed to separate the phosphoinositides, appeared as a single band of Mr = 3500 on polyacrylamide gels in the presence of dodecyl sulfate, had an ultraviolet absorbance spectrum with a maximum at 275 nm and stained with Coomassie dye. Based on these properties this phosphorylation product is referred to as a proteolipid. The 32P label was not detected in phosphotyrosine [Tyr(P)], phosphoserine [Ser(P)] or phosphothreonine [Thr(P)] and was lost during acid or base hydrolysis. Phosphorylation of proteolipid was increased significantly by EGF, whereas phosphorylation of phosphatidic acid was decreased and labeling of phosphoinositides was unaffected. Thus, it appears that in A431 membranes the EGF receptor/kinase does not utilize phosphatidylinositol as a substrate, but does phosphorylate a membrane proteolipid

  10. Combination of radiotherapy and cetuximab for patients suffering from of an advanced and non operable epidermoid carcinoma of the ORL sphere: results and side effects; Association de radiotherapie et de cetuximab chez des patients atteints d'un carcinome epidermoide de la sphere ORL evolue non operable: resultats et effets secondaires

    Energy Technology Data Exchange (ETDEWEB)

    Acevedo, C.; Valette, G.; Bouchekoua, M.; Marianowski, R.; Pradier, O. [CHU Morvan, 29 - Brest (France)

    2010-10-15

    The authors report a retrospective survey of a set of locally advanced epidermoid carcinomas treated by irradiation and cetuximab. They assessed the response to the treatment, the specific survival, and the global survival as well as the tolerance. The survey is based on 31 men and 5 women suffering from different stage 4 non-metastatic advanced epidermoid carcinomas of the ORL sphere. Short communication

  11. Primary testicular mucinous cystadenoma: Case report and literature review.

    Science.gov (United States)

    de Lima, Mário Maciel; de Lima, Mário Maciel; Granja, Fabiana

    2015-01-01

    Testicular mucinous cystadenomas are rare in urological practice, and their histogenesis, course and management are debated. We report a primary testicular mucinous cystadenoma in a 54-year old male who presented with left testicular swelling and pain. He denied having a history of cryptorchidism, testicular trauma, infections, urinary complaints, or febrile illnesses. He did not have diabetes, but was on treatment for hypertension. The patient underwent a left inguinal radical orchiectomy, and histological examination of the resected tumour confirmed a primary testicular mucinous cystadenoma. The patient had an uneventful recovery, and is being followed up. Conclusively, urologists need to maintain a high index of suspicion of these tumours and their differentiation from metastatic tumours to ensure optimal therapeutic outcomes. PMID:26600891

  12. Enucleación de quiste periapical simultáneo a la obturación del sistema de conductos radiculares

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    Lida Velazque

    2014-06-01

    Full Text Available Introducción: los quistes periapicales representan el tipo más frecuente dentro de los quistes odontogénicos. Su origen está relacionado con una necrosis pulpar y un consecuente estímulo de los restos epiteliales del ligamento periodontal (Malassez. Objetivo: describir un caso clínico de enucleación de quiste periapical simultáneo a la obturación del sistema de conductos radiculares. Presentación del caso: paciente de sexo femenino, 67 años de edad, sin alteraciones sistémicas; buscó atención odontológica por presentar dolor dental y acúmulo de alimentos en la región de molares inferiores del lado izquierdo. Al examen clínico se observó caries extensa en el segundo molar inferior izquierdo con compromiso de furca, ausencia de aumento de volumen vestibular, sin fistula; en la radiografía periapical se evidenció lesión cariosa extensa recidivante en el segundo molar inferior izquierdo, y primer molar inferior izquierdo con tratamiento endodóntico y presencia de área radiolúcida de contornos bien definidos en la región periapical compatible con quiste periapical. El tratamiento estuvo a cargo de un equipo multidisciplinario por lo que se decidió realizar exodoncia del segundo molar inferior izquierdo y cirugía paraendodóntica con enucleación quirúrgica simultánea a la obturación del sistema de conductos radiculares primer molar inferior izquierdo; el examen histopatológico de la muestra extraída comprobó tratarse de un quiste periapical. Se realizó seguimiento radiográfico dos años después y mostró un completo reparo óseo del área afectada. Conclusiones: se concluye que el tratamiento descrito constituye una alternativa válida para la resolución de casos donde la endodoncia convencional es limitada para mantener la función y estética de una pieza dentaria.

  13. Radiotherapy Treatment Planning for Testicular Seminoma

    Energy Technology Data Exchange (ETDEWEB)

    Wilder, Richard B., E-mail: richardbwilder@yahoo.com [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL (United States); Buyyounouski, Mark K. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Efstathiou, Jason A. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Beard, Clair J. [Department of Radiation Oncology, Dana-Farber/Brigham and Women' s Cancer Center, Boston, MA (United States)

    2012-07-15

    Virtually all patients with Stage I testicular seminoma are cured regardless of postorchiectomy management. For patients treated with adjuvant radiotherapy, late toxicity is a major concern. However, toxicity may be limited by radiotherapy techniques that minimize radiation exposure of healthy normal tissues. This article is an evidence-based review that provides radiotherapy treatment planning recommendations for testicular seminoma. The minority of Stage I patients who choose adjuvant treatment over surveillance may be considered for (1) para-aortic irradiation to 20 Gy in 10 fractions, or (2) carboplatin chemotherapy consisting of area under the curve, AUC = 7 Multiplication-Sign 1-2 cycles. Two-dimensional radiotherapy based on bony anatomy is a simple and effective treatment for Stage IIA or IIB testicular seminoma. Centers with expertise in vascular and nodal anatomy may consider use of anteroposterior-posteroanterior fields based on three-dimensional conformal radiotherapy instead. For modified dog-leg fields delivering 20 Gy in 10 fractions, clinical studies support placement of the inferior border at the top of the acetabulum. Clinical and nodal mapping studies support placement of the superior border of all radiotherapy fields at the top of the T12 vertebral body. For Stage IIA and IIB patients, an anteroposterior-posteroanterior boost is then delivered to the adenopathy with a 2-cm margin to the block edge. The boost dose consists of 10 Gy in 5 fractions for Stage IIA and 16 Gy in 8 fractions for Stage IIB. Alternatively, bleomycin, etoposide, and cisplatin chemotherapy for 3 cycles or etoposide and cisplatin chemotherapy for 4 cycles may be delivered to Stage IIA or IIB patients (e.g., if they have a horseshoe kidney, inflammatory bowel disease, or a history of radiotherapy).

  14. Radiotherapy Treatment Planning for Testicular Seminoma

    International Nuclear Information System (INIS)

    Virtually all patients with Stage I testicular seminoma are cured regardless of postorchiectomy management. For patients treated with adjuvant radiotherapy, late toxicity is a major concern. However, toxicity may be limited by radiotherapy techniques that minimize radiation exposure of healthy normal tissues. This article is an evidence-based review that provides radiotherapy treatment planning recommendations for testicular seminoma. The minority of Stage I patients who choose adjuvant treatment over surveillance may be considered for (1) para-aortic irradiation to 20 Gy in 10 fractions, or (2) carboplatin chemotherapy consisting of area under the curve, AUC = 7 × 1?2 cycles. Two-dimensional radiotherapy based on bony anatomy is a simple and effective treatment for Stage IIA or IIB testicular seminoma. Centers with expertise in vascular and nodal anatomy may consider use of anteroposterior–posteroanterior fields based on three-dimensional conformal radiotherapy instead. For modified dog-leg fields delivering 20 Gy in 10 fractions, clinical studies support placement of the inferior border at the top of the acetabulum. Clinical and nodal mapping studies support placement of the superior border of all radiotherapy fields at the top of the T12 vertebral body. For Stage IIA and IIB patients, an anteroposterior–posteroanterior boost is then delivered to the adenopathy with a 2-cm margin to the block edge. The boost dose consists of 10 Gy in 5 fractions for Stage IIA and 16 Gy in 8 fractions for Stage IIB. Alternatively, bleomycin, etoposide, and cisplatin chemotherapy for 3 cycles or etoposide and cisplatin chemotherapy for 4 cycles may be delivered to Stage IIA or IIB patients (e.g., if they have a horseshoe kidney, inflammatory bowel disease, or a history of radiotherapy).

  15. Quality of Life of Testicular Cancer Survivors

    OpenAIRE

    Fleer, Joke,

    2006-01-01

    Men who are diagnosed with testicular cancer are generally young. As a consequence of the treatment they receive nowadays, they are likely to cure from the disease, even when they have metastases. This means that they have to live with possible short- and long-term sequel of diagnosis and treatment for many years. Survivors who do not have the resources necessary to cope with such physical and psychosocial sequel, may find it more difficult to adjust to their altered life situation and experi...

  16. [Sigmovaginoplasty in patient with testicular feminization syndrome].

    Science.gov (United States)

    Komiakov, B K; Guliev, B G; Onoshko, M V

    2014-01-01

    The article presents the description of the clinical observation of the 36 years old patient with testicular feminization syndrome: genetic (karyotype 46 XY) and gonadal male sex, female external genitalia and the absence of derivatives of Mullerian ducts (uterus, fallopian tubes, the upper third of the vagina). At the first stage, testes were removed; then, vaginoplasty using segment of the sigmoid colon for possible sexual intercourse was performed. There were no complications. Currently, the patient's condition is satisfactory; she lives a regular sex life. PMID:25211931

  17. Epidermoid bronchogenic carcinoma in a 21 year old black man Carcinoma broncogénico epidermoide en un hombre de 21 años

    Directory of Open Access Journals (Sweden)

    Dianelisa De La Hoz Rodríguez

    1999-01-01

    Full Text Available A 21 year cid black man, native from Chocó (Colombia, variously employed, who presented with a respiratory difficulty syndrome of two months of evolution, right pleuritic pain, congestive cardiac failure and systemic symptoms. A homogeneic white .grayish tumor measuring 8 by 10 cm with necrotic areas was found at necropsy. The tumor originated in the main bronchial tube of the lower and middle lobes of the right lung and invaded the entire pericardial vicinity forming a cuirass and causing tumoral constrictive pericarditis. Microscopic studies revealed a well differentiated squamous type bronchogenic carcinoma. Bronchogenic carcinomas are frequently associated with cigarette smoking. However, their incidente has increased among non. smokers, suggesting the possibility that there are other causal factors, such as atmospheric contaminants, genetic predisposition, diets deficient in vitamin A and carotene, presente of certain viruses and immunologic changes. Lung cancer constitutes 16% among the types of cancer suffered by men and 13% among women, it has its greatest incidente in groups between 40 and 70 years of age and only 1 to 5 percent of thecasesoccur in groupsunder theageofforty years. Hombre de 21 años de edad de raza negra, natural del Chocó (Colombia, quien ha desempeñado diversos oficios; presentó un síndrome de dificultad respiratoria de dos meses de evolución, dolor pleurítico derecho, insuficiencia cardíaca congestiva y síntomas sistémicos. En la necropsia se encontró una masa tumoral blanco-grisácea de 10 x 8 cm, homogénea, con áreas de necrosis, originada en el bronquio principal de los lóbulos inferior y medio derechos y que invadió por vecindad en forma de coraza todo el pericardio causando una pericarditis constrictiva tumoral. El estudio microscópico correspondió a un carcinoma broncogénico tipo epidermoide bien diferenciado. El carcinoma broncogénico se asocia frecuentemente con el consumo de cigarrillo pero su incidencia ha c.umentado entre las personas no fumadoras, lo que sugiere la posibilidad de otros factores que influyen en su presentación como son los contaminantes atmósféricos, la predisposición genética, la dieta deficiente en vitamina A y carotenos, la presencia de ciertos virus y cambios inmunológicos. Este tumor constituye el 16% de todos los cánceres en el hombre y e113% en las mujeres; aparece con mayor frecuencia entre los 40 y los 70 años y sólo del1 al 5% de los casos se presenta en menores de 40 años.

  18. Re-irradiation in stereotactic conditions and cetuximab for local relapses of epidermoid carcinoma of head and neck; Reirradiation en conditions stereotaxiques et cetuximab pour des recidives locales de carcinome epidermoide de la tete et du cou

    Energy Technology Data Exchange (ETDEWEB)

    Vasseur, F.; Comet, B.; Faivre-Pierret, M.; Coche-Dequeant, B.; Degardin, M.; Lefebvre, J.L.; Lacornerie, T.; Lartigau, E. [Departement universitaire de radiotherapie, centre Oscar Lambret, 59 - Lille (France); Universite Lille-2, 59 (France)

    2010-10-15

    The authors report a work aimed at assessing the feasibility and toxicity of a re-irradiation treatment in stereotactic conditions using CyberKnife and cetuximab in the case of local relapses of epidermoid cancers of the ORL sphere. Thirty three patients have been submitted to this treatment between June 2007 and April 2009. Although six patients died by six months, this treatment seems to be a good alternative, and presents an acceptable short-term toxicity. Further studies are needed to compare this technique to other therapeutic techniques, and to assess the risk of long term complications. Short communication

  19. Quiste dermoide en la infancia bajo el diagnóstico de ptosis / Dermoid cyst in chidhood, diagnosed as ptosis

    Scientific Electronic Library Online (English)

    M.E., Correa Pérez; H., Sánchez-Tocino; G., Blanco Mateos.

    2010-06-01

    Full Text Available Caso clínico: Niño de 4 años diagnosticado por su pediatra de ptosis congénita en ojo izquierdo a los 2 años. En su valoración oftalmológica inicial, únicamente se aprecia discreta asimetría entre los párpados superiores. Es en consultas posteriores cuando aparece discreta hipotropia del ojo izquier [...] do, y un astigmatismo creciente que hacen sospechar sobre patología orbitaria. La RMN confirma la presencia de una masa compatible con un quiste dermoide. Conclusión: Debido al crecimiento lento de estos tumores, sólo un seguimiento de la clínica y la ayuda de pruebas de imagen, llevará al diagnóstico y al tratamiento definitivo mediante extirpación quirúrgica. Abstract in english Clinical case: A four year-old boy, diagnosed of palpebral ptosis since he was 2 by his paediatrician. At the initial ophthalmological revies he had asymmetrical upper eyelids. In the follow-up a mild ocular hypotrophy appeared in his left eye and an increasing astigmatism, which made us suspect an [...] orbital disease. The MRI confirmed a mass, compatible with a dermoid cyst. Conclusion: Due to the slow growth of these tumours, it is only with clinical follow-up and the aid of imaging techniques that we may achieve the diagnosis and offer a definitive treatment with surgical extirpation.

  20. Evaluation of Doppler Indices in Varicocele-Related Testicular Atrophy

    Directory of Open Access Journals (Sweden)

    Masoud Nemati

    2010-05-01

    Full Text Available Background/Objective: Varicocele is a well-recognized cause of decreased testicular function and atrophy and occurs in approximately 15-20% of all men and 40% of infertile men. The aim of this study was to evaluate varicocele-related testicular atrophy with Duplex sonography. "nPatients and Methods: Fifty patients (mean age 24±7.43 with testicular atrophy due to varicocele were included in the study during 2005-2008."nResults: Echogenicity of the atrophic testis was homogeneous. The mean peak systolic velocity (PSV and resistive index (RI in intratesticular arteries for atrophic and normal testes were 5.45 ± 2.22 cm/s, 0.63±0.12 and 6.38 ±2.12 cm/s, 0.61± 0.17, respectively. The differences were not significant (P > 0.05. "nConclusion: Varicocele-related testicular atrophy is not associated with testicular parenchymal heterogeneity and it does not affect the intratesticular and testicular arterial PSV or RI."nKeywords: Varicocele, Testicular Atrophy, Peak Systolic Velocity, Resistive Index

  1. Review of photodynamic therapy with 5-methyl aminolevulinate in actinic keratosis, epidermoid carcinoma and basal cell carcinoma

    International Nuclear Information System (INIS)

    A bibliographic review was conduced on the use of 5-methyl aminolevulinate in dermatology, specifically in the treatment of actinic keratosis, epidermoid carcinoma and basal cell carcinoma. The basic fundamentals of photodynamic therapy are described. The preparation and method of use of photodynamic therapy with 5-methyl aminolevulinate (MAL-PDT) are detailed. The clinical studies that were realized with photodynamic therapy for the treatment of actinic keratosis, epidermoid carcinoma and basal cell carcinoma are mentioned. Different photo-inducible agents and other current therapeutic options of first-line are compared. The MAL-PDT has have the advantage of to present less side effects and the same have been more tolerable than liquid nitrogen and 5 fluorouracil. The MAL-PDT has been considered as an effective option for the treatment of Bowen's disease. Invasive epidermoid carcinoma has existed without evidence to support the routine use of this therapeutic. For superficial basal cell carcinoma, the MAL-PDT has presented a high cure rate and transient and manageable side effects in extensive and multiple lesions. The MAL-PDT has been an effective and safe treatment in patients with basal cell carcinoma, for those with less depth of 2mm. The MAL-PDT could play an important role in the field of prevention with immunosuppressed patients, particularly, those that have required transplant and its immunosuppression has been pharmacological. The use or not of the MAL-PDT, should be evaluated individually for each patient and to have suitable characteristics for each disease that was cited in this review. The photodynamic therapy with 5-methyl aminolevulinate has been a therapeutic modality of considerable economy, however, it should be evaluated in the context of number of inquiries and side effects that have offered other therapeutic modalities

  2. Intracranial epidermoid cysts: diffusion-weighted, FLAIR and conventional MR findings

    Energy Technology Data Exchange (ETDEWEB)

    Hakyemez, Bahattin [Department of Radiology, Burtom Radioimaging Center, Ataturk cad, Feraizcizade sok., NO:1, Osmangazi, Bursa (Turkey)]. E-mail: bahattinh@hotmail.com; Aksoy, Umit [Department of Radiology, Bursa State Hospital, Bursa (Turkey); Yildiz, Harun [Department of Radiology, Suleyman Demirel University Medical School, Isparta (Turkey); Ergin, Necdet [Department of Neurosurgery, Bursa State Hospital, Bursa (Turkey)

    2005-05-01

    Purpose: To compare diffusion-weighted echo-planar imaging (DW) with spin-echo (SE), and fluid-attenuated inversion recovery (FLAIR) sequences in the evaluation of epidermoid cysts (ECs), and to evaluate T2 shine-through effect. Materials and methods: Fifteen patients were imaged prospectively in two different 1.5 T magnetic resonance (MR) units with standard head coils with SE, FLAIR and DW echo planar imaging sequences. The qualitative and quantitative assessments were performed by two radiologists in consensus. Apparent diffusion coefficient (ADC) values were obtained from all ECs. Exponential DW images are obtained in 11 cases to eliminate T2 shine-through effects. The results are analyzed with variance analysis (ANOVA) and Bonferroni t method. Results: FLAIR sequence was superior to T1- and T2-weighted sequences in showing ECs. In 13 cases, the borders of the lesions could be delineated from the surrounding structures with only DW imaging where ECs were markedly hyperintense. The ADC values of ECs are significantly lower than CSF (P < 0.001), and significantly higher than deep white matter (P < 0.01). On exponential DW images, ECs had similar intensity with brain parenchyma showing that the real cause of the hyperintensity of the lesions on trace images is the enhanced T2 effect of the tissue. Conclusion: FLAIR sequence is superior to the conventional MR sequences in demonstrating the ECs and DW imaging is superior to other MR sequences in delineating the borders of the ECs. Exponential DW images had shown that the hyperintensity in the trace images are caused by increased T2 effect of the lesion rather than the decrease in ADC values.

  3. Epidermoid carcinoma of the anal canal. A series of 276 cases

    Energy Technology Data Exchange (ETDEWEB)

    Papillon, J.; Montbarbon, J.F.

    1987-05-01

    During the past ten years, substantial progress has been made in the knowledge of the natural history of epidermoid carcinoma of the anal canal and of the response of the disease to radiotherapy alone or combined with chemotherapy. At the present time, the main problem in the management of this tumor concerns identification of the best modalities to achieve local control and preservation of anal function. From a series of 276 cases, followed for more than three years, the necessity for a careful pretreatment evaluation was stressed. This included a systematic search for pelvic metastatic lymph nodes by palpation and CT scan. All patients were treated initially by irradiation except those who underwent groin dissection for inguinal node metastasis or colostomy for complete anal obstruction. Three groups of patients have been identified: unresectable or disseminated tumors (33 cases), resectable tumors but not suitable for sphincter conservation (21 cases) treated by radiochemotherapy and delayed surgery, and resectable tumors suitable for sphincter conservation (222 cases) which were treated by a split-course regimen combining a short course of carefully planned external beam irradiation (19 days) followed by an iridium 192 implant after a two-month rest. In this group, which represents 80 percent of the whole series, 80 percent of patients have had their cancer controlled and 90 percent of controlled patients have retained normal anal function. The use of chemotherapy during the first days of irradiation is advisable in all cases to reinforce the efficacy of treatment and increase the chance of anal preservation. Results of the split-course regimen, combining external beam and interstitial irradiation, demonstrate a clear superiority over external beam irradiation alone, especially for large infiltrating tumors, which represent the majority of cases.

  4. Combined interstitial and external radiotherapy following limited surgery of epidermoid carcinomas of the iral cavity

    International Nuclear Information System (INIS)

    From 1.1.1986 to 31.12.1990 50 patients with epidermoid carcinoma of the floor of the mouth and the mobile tongue (stage T1 18, stage T2 20, stage T3 eight and stage T4 four patients) were treated by surgery, 192-iridium implantation using the plastic tube technique and percutaneous irradiation. Survey was performed as enoral resection (35 patients) or en bloc tumour resection with part of the mandible and flap reconstruction (15 patients). Interstitial therapy was considered as a boost to primary tumour region, the dose given ranged between 16 and 33 Gy. 50 to 60 Gy were applied with external beam radiotherapy. Management of the neck consisted of elective or radical neck dissection followed by external beam radiotherapy (50 to 60 Gy). At 2/1991 median follow-up was 17 (three to 53) months. 35 patients are alive and tumour-free, one patient lives with tumour. 14 patients died, eight patients tumour-related, four patients of intercurrent disease and two patients because of a second primary. Primary local control was 18/18 patients for stage T1, 19/20 patients for stage T2, 7/8 patients T3, 3/4 patients for stage T4. Three patients suffered from nodal recurrences, four patients from distant metastases. Complication rate was acceptable. Soft tissue necrosis occurred in 4/18 patients (T1); 5/20 patients (T2); 3/8 patients (T3) and 1/4 patients (T4). Three patients developed osteoradionecrosis. Our results show that combined modality treatment for tumours of the oral cavity yields high local control with acceptable complication rate. (orig.)

  5. A Case of Giant Epidermoid Cyst in the Floor of the Mouth That Caused Severe Obstructive Sleep Apnea Syndrome

    OpenAIRE

    Norimichi Nakamoto; Tsuyoshi Sato; Yoshie Sano; Makoto Kabeya; Yuichiro Enoki; Yasuaki Sakata; Tetsuya Yoda

    2014-01-01

    We describe here, a case with a giant epidermoid cyst in the floor of the mouth that caused severe obstructive sleep apnea syndrome (OSAS). A 37-year-old man was referred to our clinic because of a swelling in the floor of his mouth and sleep apnea syndrome. The occurrence of breathing disorders and daytime drowsiness was monitored to evaluate his OSAS 1 day before and 7 days after surgery. Before surgery, the apnea-hyponea index (AHI) and Epworth Sleepiness Scale (ESS) were 45.7 and 22, resp...

  6. Intraoral removal of a large epidermoid cyst of the floor of the mouth. A case report and review of the literature.

    Directory of Open Access Journals (Sweden)

    Fotios TZERMPOS

    2014-12-01

    Full Text Available SUMMARY: The intraoral dermoid cysts constitute less than 0.01% of all oral cavity cysts and are most commonly located in the midline of the floor of the mouth. Histologically they are divided into epidermoid, dermoid and teratoid. The surgical excision can be performed either intraorally or extraorally and the choice of treatment can be determined by the localization and the size of the lesion. In this article, a case of a large epidermoid cyst of the floor of the mouth removed by intraoral excision under local anesthesia with i.v. sedation is presented.

  7. Metastatic Testicular Choriocarcinoma: A Rare Cause of Upper GI Bleeding.

    Science.gov (United States)

    Lowe, Kirsty; Paterson, Jacqueline; Armstrong, Sharon; Walsh, Shaun; Groome, Max; Mowat, Craig

    2015-10-01

    We present a case of upper gastrointestinal bleeding in an otherwise healthy 18-year-old man who presented with melena. Endoscopy revealed an ulcerated mass in the stomach and pathology confirmed this to be a malignant, poorly differentiated choriocarcinoma. Further imaging showed a left testicular mass with evidence of pulmonary, gastric, and brain metastases, and blood tests revealed an hCG level of 32,219 U/L. He was diagnosed with advanced metastatic testicular choriocarcinoma and underwent intensive induction chemotherapy and an orchidectomy. Metastatic testicular choriocarcinoma is a rare cause of gastrointestinal bleeding. PMID:26504875

  8. Testicular tumors: correlation between radiological findings and pathology results

    International Nuclear Information System (INIS)

    The aim of this study is to review the main imaging findings and the pathological and clinical features seen on patients with testicular tumors in order to define characteristics that may help in the differential diagnosis of the most frequent lesions. We performed a retrospective study of 51 patients with diagnosis of testicular tumors submitted to ultrasound and computed tomography between July 2003 to March 2004 that were referred to the Diagnostic Department of Sao Paulo University, Sao Paulo Hospital, Brazil. We concluded that a basic knowledge of the key imaging findings and pathological and clinical features of testicular tumor sis very helpful for an accurate diagnosis of this condition.(author)

  9. Evaluation of Doppler Indices in Varicocele-Related Testicular Atrophy

    OpenAIRE

    Masoud Nemati; Abolhassan Shakeri Bavil

    2010-01-01

    Background/Objective: Varicocele is a well-recognized cause of decreased testicular function and atrophy and occurs in approximately 15-20% of all men and 40% of infertile men. The aim of this study was to evaluate varicocele-related testicular atrophy with Duplex sonography. "nPatients and Methods: Fifty patients (mean age 24±7.43) with testicular atrophy due to varicocele were included in the study during 2005-2008."nResults: Echogenicity of the atrophic testis was homo...

  10. Radiation treatment of testicular relapse in acute lymphoblastic leukemia

    International Nuclear Information System (INIS)

    Ten patients with testicular relapse among 128 cases of acute lymphoblastic leukemia are reported. At the time of the initial diagnosis of leukemia all patients with later testicular relapse showed one or more risk factors as predictive for leukemic infiltration of the testicles. All patients except one, who underwent orchiectomy and died 11 weeks after surgical intervention, received radiation therapy with doses ranging from 12 to 20 Gy and chemotherapy. The local control was excellent. Average survival time from testicular relapse to death was 68 weeks in 8 of 9 patients treated by irradiation and chemotherapy. One patient is still alive without signs of disease after 6 years. (orig.)

  11. Metástasis testicular metacrónica secundaria a adenocarcinoma renal de células claras / Metachronic testicular metastasis secondary to clear cell renal adenocarcinoma

    Scientific Electronic Library Online (English)

    Roberto, Llarena Ibarguren; Jorge, García-Olaverri Rodríguez; Igor, Azurmendi Arin; Ivan, Olano Grasa; Carlos, Pertusa Peña.

    2008-05-01

    Full Text Available Objetivo: Presentar un caso de metástasis inusual en testículo de origen renal. Método: Paciente de 57 años afecto y en tratamiento por un cáncer renal derecho diseminado que durante su evolución con terapia médica aparecieron metástasis óseas y un nódulo doloroso en polo superior testicular derecho [...] , que obligó a cirugía, con resultado de metástasis de adenocarcinoma de células claras. Resultado: A los 6 meses el paciente sigue en tratamiento con sorafenib oral sin que se hayan manifestado más implantes metastáticos. Conclusiones: Los tumores secundarios metástasicos en testes suponen menos del 1% del total de tumores testiculares. En pacientes en la 5ª y 6ª década, sobre todo afectos de otras neoplasias, las masas testiculares acostumbran a ser implantes metastáticos. El origen más frecuente es el prostático. Abstract in english Objective: To report one case of unusual testicular metastasis from a renal origin. Methods: 57-year-old patient with disseminated right renal cancer under treatment who presented bone metastasis and a painful nodule in the upper pole of the right testicle during his follow-up with medical therapy, [...] making surgery necessary. The pathology result was clear cell adenocarcinoma. Results: Six months later the patient continues under oral Sorafenib without evidence of new metastatic implants. Conclusions: Testicular secondary metastatic tumors account for less than 1% of old testicular tumors. In patients in the fifth and sixth decades, mainly if they are affected by other neoplasias, testicular masses use to be metastatic implants. The most frequent origin is prostate.

  12. HISTOLOGIA TESTICULAR HUMANA COMPARADA, ADULTO JOVEN Y SENIL HUMAN TESTICULAR HISTOLOGY IN YOUNG AND SENILE MEN

    OpenAIRE

    Héctor Rodríguez; Paulina Salazar; Nadia Schmidt; Patricia Torres; Enrique Ossandón

    1999-01-01

    In general, sperm production decreases with advanced age in men. Therefore the present work compares the histology and cellularity of aging human testis with that of a young adult. Gonads from three patients 69 years old and testis from a young subject (aged 25 years) were examined after histological standard techniques (PAS-Haematoxyline). Histological, morphometric and cell counting analyses of testicular sections revealed that the seminiferous tubules of senile patients were of smaller dia...

  13. Manejo multidisciplinario en la recidiva de carcinoma epidermoide de conducto auditivo externo. Presentación de un caso / Multidisciplinary handling of epidermoid carcinoma in the external auditory canal. Presentation of a case

    Scientific Electronic Library Online (English)

    Misleidy, Nápoles Morales; Orlando, Cruz García; Juan Carlos, Alfonso Coto; Pedro Pablo, Morales; Carlos F, Calderón Marín; Eduardo, Larrinaga Cortinas; Jorge Juan, Marinillo Guerrero; Betty, Santodomingo Reyna.

    2011-06-01

    Full Text Available Se presenta un paciente de 42 años con el diagnóstico de un carcinoma epidermoide bien diferenciado de conducto auditivo externo (CAE), diagnosticado en junio de 2008. El mismo recibió radioterapia como tratamiento con intención curativa a dosis radical 66 Gy. En enero de 2010, comenzó con aumento d [...] e volumen exagerado del conducto auditivo externo, discutiéndose en los servicios de Neurocirugía, Radioterapia y Cirugía Reconstructiva del Instituto Nacional de Oncología y Radiobiología. Al paciente se le realiza la exéresis total del tumor, una radioterapia intraoperatoria fraccionada con electrones (EIORT) y reconstrucción local con colgajo músculo cutáneo del pectoral mayor. El tratamiento resultó ser tolerado por el paciente aumentándole su expectativa y calidad de vida. Abstract in english A 42 year-old patient is presented with the diagnostic of an Epidermoid Carcinoma of the external auditory canal on June 2008. He had got a radical radiotherapy as treatment with a completely response but in January 2010 he return with the tumour in the same place. It was the reason to discuss this [...] patient in different department as Neurosurgery, Radiotherapy and Reconstructive Surgery. This patient received a total remove of the tumour, Intraoperative Radiotherapy with electron (EIORT) and a local reconstruction with mayor Pectoral Muscle. As Result the treatments were bear by the patient increasing his expectative and quality life.

  14. OPTIMIZACIÓN EN LA ESTRATEGIA DIAGNÓSTICA Y TERAPÉUTICA EN EL QUISTE DE COLÉDOCO / Optimization in diagnostic and therapeutic strategy of choledochal cyst

    Scientific Electronic Library Online (English)

    Grecia Victoria, Vivas-Colmenares; Ana, Millán-López; Juan Carlos, De Agustín A.

    2015-06-01

    Full Text Available Objetivos: El quiste de colédoco presenta una incidencia de 1 en 100.000-150.000. El propósito de este estudio fue analizar las variables introducidas para la optimización en el diagnóstico y tratamiento del quiste de colédoco. Material y Métodos: Estudio retrospectivo de pacientes intervenidos en n [...] uestro centro de quiste de colédoco mediante hepático-yeyunostomía en Y de Roux, desde septiembre de 1988 a noviembre de 2012. Se analizan 40 variables incluyendo edad, sintomatología, tipo de quiste, pruebas diagnósticas, cambios en la técnica quirúrgica, complicaciones y evolución. Resultados: 18 pacientes (66,6% mujeres) fueron agrupados de acuerdo a la edad de presentación: Prenatal ( 24 meses). Los síntomas más frecuentes fueron ictericia y dolor abdominal (para los de inicio precoz y tardío respectivamente). El 83,3% presentaban quistes de colédoco tipo I; siendo suficiente la ecografía para el diagnóstico en el 94,4%. A partir de 2004 modificamos la técnica quirúrgica, realizando por vía laparoscópica la disección de la vía biliar y mediante laparotomía mínima (3-5 cm) hepático-yeyunostomía con asa descendente de 40 cm, empleando sutura de polipropileno, observando desde el 2004, sólo 1 dehiscencia parcial de la anastomosis, resuelta con tratamiento conservador y 1 colangitis en paciente con poliquistosis hepática y renal. En el año 2012 el 83,3% están asintomáticos. Conclusiones: El diagnóstico se ha simplificado, en más de 90% de los casos se realiza sólo con ecografía; los avances en cirugía mínimamente invasiva y la creación de asa descendente de 40 cm, han logrado optimizar el pronóstico del quiste de colédoco. Abstract in english Objectives: The choledochal cyst has an incidence of 1 in 100.000-150.000. The purpose of this study was to analyze the variables introduced for the optimization in the diagnosis and treatment of choledochal cyst. Material and Methods: Retrospective study of patients treated in our center by hepatic [...] -jejunostomy and Roux-Y, from September 1988 to November 2012. We analyzed 40 variables including age, symptoms, type of cysts, diagnostic tests, changes in surgical technique, complications and outcomes. Results: Eighteen patients (66.6% female) were grouped according to the age of presentation: Prenatal ( 24 months). The most common symptoms were jaundice and abdominal pain (for early-onset and late-onset respectively). The 83.3% presented choledochal cysts type I, the ultrasound was sufficient for diagnosis in 94.4%. Since 2004 we modified the surgical technique, performing laparoscopic dissection of the bile duct and cyst, adding a mini-laparotomy (3-5 cm) for hepatic-jejunostomy with 40 cm intestinal loop using polypropylene suture. One complication was observed since 2004, one case of partial dehiscence of the anastomosis resolved with conservative treatment and a cholangitis in 1 patient with hepatic and renal polycystic. In 2012, 83.3% are asymptomatic. Conclusions: The diagnostic have been simplified, in more than 90% of cases was done by ultrasound; advances in minimally invasive surgery and creation of descending loop of 40 cm, have helped to improve the prognosis of choledochal cyst.

  15. Testicular tumors: correlation between radiological findings and pathology results; Neoplasias testiculares: aspectos ultra-sonograficos com correlacao anatomopatologica

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Luis Ronan Marques Ferreira de; Szejnfeld, Denis; Abud, Thiago G.; Szejnfeld, Jacob [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. de Diagnostico por Imagem]. E-mail: luisronan@gmail.com; Takano, Daniela Mayumi [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. de Anatomia Patologica; Goldman, Suzan Menasce [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Setor de Geniturinario

    2005-10-15

    The aim of this study is to review the main imaging findings and the pathological and clinical features seen on patients with testicular tumors in order to define characteristics that may help in the differential diagnosis of the most frequent lesions. We performed a retrospective study of 51 patients with diagnosis of testicular tumors submitted to ultrasound and computed tomography between July 2003 to March 2004 that were referred to the Diagnostic Department of Sao Paulo University, Sao Paulo Hospital, Brazil. We concluded that a basic knowledge of the key imaging findings and pathological and clinical features of testicular tumor sis very helpful for an accurate diagnosis of this condition.(author)

  16. Diagnóstico y tratamiento de los quistes de colédoco: Presentación de 10 nuevos casos Diagnosis and management of choledochal cysts: A review of 10 new cases

    OpenAIRE

    R. Uribarrena Amezaga; N. Raventós; Fuentes, J.; J. Elías; V. Tejedo; R. Uribarrena Echebarría

    2008-01-01

    Objetivo: analizar las técnicas diagnósticas y las distintas posibilidades terapéuticas de esta rara patología. Pacientes y métodos: presentamos un estudio retrospectivo de todos los casos de quistes de colédoco diagnosticados en nuestro hospital desde 1991. Incluye 10 nuevos casos y distintos tipos de quistes de colédoco (QC). Resultados: de los 10 pacientes diagnosticados de QC siete tenían menos de 10 años. En cuanto a los diferentes tipos de QC: 7 eran de tipo I, 1 de tipo III, 1 de tipo ...

  17. Fractura patológica de la mandíbula asociada a quiste radicular: Reporte de 3 casos clínicos Mandibular pathologic fracture associated with radicular cyst: Report of three clinical cases

    Directory of Open Access Journals (Sweden)

    J. Bouguila

    2008-08-01

    Full Text Available Introducción. El quiste radicular es el quiste más común de los maxilares. Su tamaño puede variar desde una lesión que abarca el proceso alveolar hasta uno extenso que oblitera el espacio antral maxilar o causa una fractura patológica mandibular. Reporte de casos. Se reportan tres casos con fractura patológica mandibular asociados a quiste radicular ocurridos después de trauma facial. El diagnóstico fue sugerido por un estudio clínico, radiografía panorámica y confirmado por el estudio histopatológico de la pieza operatoria. El tratamiento consistió en enucleación quística seguido por inmovilización de fragmentos con osteosíntesis o bloqueo intermaxilar. El resultado clínico y radiológico a corto plazo fue favorable. Discusión. Se discuten aspectos propios de la patología y su terapia. Conclusión. El éxito del tratamiento depende de una adecuada terapia en que sus principios más importantes son la remoción de la lesión mediante enucleación y una fijación estable.Introduction. Radicular cyst is the most common cyst of the oral cavity. It may range in size from a small periapical lesion to one that can obliterate the antral space or cause mandibular fracture. Case reports. We report three cases of radicular cyst complicated by mandibular fracture that occurred after maxillofacial trauma. The diagnosis was strongly suggested by panoramic radiography and confirmed by pathology examination of the operative specimen. Treatment consisted in cyst enucleation followed by immobilization of fragments by osteosynthesis or maxillomandibular fixation. The clinical and radiologic outcome was favorable. Discussion. The particularities and treatment are discussed. Conclusion. Treatment success is dependent on adequate therapy, the principles of which are removing the lesion and providing stable fixation.

  18. Fractura patológica de la mandíbula asociada a quiste radicular: Reporte de 3 casos clínicos / Mandibular pathologic fracture associated with radicular cyst: Report of three clinical cases

    Scientific Electronic Library Online (English)

    J., Bouguila; L., Córdova Jara; I., Zairi; A., Adouani.

    2008-08-01

    Full Text Available Introducción. El quiste radicular es el quiste más común de los maxilares. Su tamaño puede variar desde una lesión que abarca el proceso alveolar hasta uno extenso que oblitera el espacio antral maxilar o causa una fractura patológica mandibular. Reporte de casos. Se reportan tres casos con fractura [...] patológica mandibular asociados a quiste radicular ocurridos después de trauma facial. El diagnóstico fue sugerido por un estudio clínico, radiografía panorámica y confirmado por el estudio histopatológico de la pieza operatoria. El tratamiento consistió en enucleación quística seguido por inmovilización de fragmentos con osteosíntesis o bloqueo intermaxilar. El resultado clínico y radiológico a corto plazo fue favorable. Discusión. Se discuten aspectos propios de la patología y su terapia. Conclusión. El éxito del tratamiento depende de una adecuada terapia en que sus principios más importantes son la remoción de la lesión mediante enucleación y una fijación estable. Abstract in english Introduction. Radicular cyst is the most common cyst of the oral cavity. It may range in size from a small periapical lesion to one that can obliterate the antral space or cause mandibular fracture. Case reports. We report three cases of radicular cyst complicated by mandibular fracture that occurre [...] d after maxillofacial trauma. The diagnosis was strongly suggested by panoramic radiography and confirmed by pathology examination of the operative specimen. Treatment consisted in cyst enucleation followed by immobilization of fragments by osteosynthesis or maxillomandibular fixation. The clinical and radiologic outcome was favorable. Discussion. The particularities and treatment are discussed. Conclusion. Treatment success is dependent on adequate therapy, the principles of which are removing the lesion and providing stable fixation.

  19. Distensión abdominal y edemas por quiste del cordón espermático Abdomina distention and edema due to spermatic cord cyst

    Directory of Open Access Journals (Sweden)

    Guillermo A. Keller

    2006-04-01

    Full Text Available La distensión abdominal es un síntoma común, siendo en general la presentación inicial de enfermedades sistémicas o desórdenes gastrointestinales. Otras causas son infrecuentes. Los quistes del cordón espermático son poco frecuentes, pero aún más su ubicación intraabdominal, su tamaño habitual es insuficiente para producir distensión. El paciente presentado en este caso es un varón con criptorquidia bilateral admitido por distensión abdominal, interpretada inicialmente como síndrome ascítico edematoso. La ecografía interpretó la distensión como ascitis tabicada, y la tomografía computada como debida a un gran quiste. En la exploración quirúrgica se diagnosticó un quiste gigante del cordón espermático de ubicación abdominal.Abdominal distention is a frequent symptom, being often the initial presentation of systemic diseases or gastrointestinal disorders. Other causes are uncommon. Spermatic cord cysts are infrequent, abdominal location is even rarer, and the size of the cysts is usually not enough to produce abdominal distention. In our case a man with bilateral cryptorchidism was admitted with abdominal distention and edema of the lower extremities initially interpreted as ascitic-edematous syndrome. Ultrasonography interpreted abdominal distention as septate ascites, computed tomography as a giant cyst. Exploratory surgery showed a giant spermatic cord cyst in the left spermatic cord.

  20. Ontogenesis of testicular function in humans.

    Directory of Open Access Journals (Sweden)

    GaĂŤlle Angenard

    2010-01-01

    Full Text Available The two major functions of the testis, steroidogenesis and gametogenesis, take place during fetal life. These two functions have been extensively studied in rodents and adult humans. However, their onset during fetal life is poorly documented in humans. In the first part of this work we presented both our experimental data and some data of literature concerning the development of the human fetal testis. In the second part of this article, using the organ culture system we previously developed, we have investigated the regulations or perturbations of fetal testis development both in rodent and human models. Our findings provide important insight into the potential role of exposure to environmental pollutants (physical factors, in particular ionizing radiation, cadmium and endocrine disruptors such as phthalates during fetal testicular development and their potential deleterious effects on male fertility in adulthood. Our results highlight the specificity of the human model compared with rodent models.

  1. ABSCESSO TESTICULAR EM HAMSTER: RELATO DE CASO

    Directory of Open Access Journals (Sweden)

    R. M. Santos

    2012-12-01

    Full Text Available The Hamster, rodent originating from the Middle East, is a species studied along with other laboratory animals as experimental models in scientific papers and currently is also created as a pet, by virtue of being docile, easy to handle and require little space for survival. The suppurative processes in domestic animals are relatively frequent. Due to infectious diseases or purulent course of aggressiveness of the environment in which they live. The habit of storing food in the cheeks with sharp edges can injure the skin and often cause abscesses in this species. However, other lesions may lead to suppuration, diseases such as testicular tumor or no tumor or not produced by damage in the skin, leading to tumescence (VITAL et al., 2007. This article reports a case of a hamster treated at the Veterinary Hospital of FAFRAM with clinical history of discomfort, anorexia and frequent licking of the scrotum. On clinical examination it was found by aspiration of purulent secretions and the presence of large numbers of polymorphonuclear cells on cytology, diagnosed with testicular abscess. The animal was taken to the operating room where was performed conventional bilateral orchiectomy and total excision of the abscess by opening the tunica vaginalis and ligation of the spermatic cord. Postoperative care included antibiotic therapy with enrofloxacin and use of an anti-inflammatory meloxicam. After ten days the stitches were removed, the wound was healing satisfactorily and the animal was in good health.O Hamster, roedor originário do Oriente Médio, é uma espécie estudada juntamente com outros animais de laboratório como modelo experimental em trabalhos científicos e, atualmente, também é criado como animal de companhia, em virtude de ser dócil, de fácil manuseio e necessitar de pequeno espaço para sobrevivência. Os processos supurativos nos animais domésticos são relativamente frequentes. Em decorrência de doenças infectocontagiosas de curso purulento ou da agressividade do meio em que vivem. No hamster, o hábito de armazenar alimentos com extremidades pontiagudas nas bochechas, pode lesionar a pele e comumente causar abscessos nesta espécie. No entanto, outras lesões podem levar à supuração, tais como afecções testiculares tumorais ou não tumorais produzidas ou não por lesão de continuidade da pele, levando à intumescência (VITAL et al., 2007. Este trabalho relata um caso de um hamster atendido no Hospital Veterinário da FAFRAM com histórico clínico de inquietação, anorexia e lambedura frequente da região escrotal. Ao exame clínico constatou-se através de punção aspirativa secreção de aspecto purulento e presença de grande quantidade de polimorfonucleares à citologia, sendo diagnosticado abscesso testicular. O animal foi encaminhado para o centro cirúrgico onde foi realizado orquiectomia bilateral convencional e exérese total do abscesso, através de abertura da túcnica vaginal e ligadura do funículo espermático. O pós-operatório incluiu antibioticoterapia com enrofloxacina e utilização de um antiinflamatório meloxican. Após dez dias os pontos foram removidos, a cicatrização da ferida cirúrgica ocorreu de maneira satisfatória e o animal apresentava-se em bom estado de saúde.

  2. Radiation therapy of testicular non-seminomas

    Energy Technology Data Exchange (ETDEWEB)

    Van der Werf-Messing, B.; Hop, W.C.J.

    1982-02-01

    The prognosis of 121 patients with a non-seminoma testicular tumor MTI or MTU was assessed. The clinical lymph node involvement and the T-category of the primary had a significant bearing on prognosis, which is completely determined by pulmonary relapse. The low-risk group (9% pulmonary relapse, all curable) is characterized by a primary category T/sub 1/ or T/sub 2/ with negative lymphangiography. The percentage of favorable patients is significantly higher if there is malignant teratoma intermediate (MTI) rather than malignant teratoma undifferentiated (MTU) histology. Systematic use of tumor markers (..beta../sub 1/-HCG and alpha fetoprotein), and perhaps an assessment of vascular invasion in the primary, might be useful to identify those patients in the unfavorable group who might benefit from elective chemotherapy.

  3. Testicular development and reproductivity in rats

    Energy Technology Data Exchange (ETDEWEB)

    Bing, Wang; Masahiro, Murakami; Kiyomi, Eguchi-Kasai; Kumie, Nojima; Yi, Shang; Kaoru, Tanaka; Kazuko, Fujita [National Institute of Radiological Sciences, Inage-ku, Chiba (Japan); Coffigny, H. [CEA Fontenay-aux-Roses, Dir. des Sciences du Vivant, 92 (France)

    2006-07-01

    Effects on gonads in prenatal male fetuses, and on the postnatal testicular development and reproductivity of male offspring were studied following exposure of pregnant Wistar rats to either accelerated carbon-ion beans with a Let value of about 13 keV/L]m or neon-ion beams with a Let value of about 30 keV/I Im at a dose range from 0.1 Gy to 2.0 Gy on gestation day 15. Induction of apoptosis in fetal gonocytes was evaluated pathologically in male gonads. Mean number of pups, pre-weaning mortality, and the age for testis descent in offspring were examined. Testis weight and the ratio of it to body weight were measured on postnatal days 30, 60 and 90, respectively. Development of testicular tubules was analyzed histologically. In addition, in the male offspring, the successful mating rates with non-irradiated female rats, the mean number of pups descended, and, the weaning rates of the pups were investigated. The effects of X-rays at 200 kVp estimated for the same biological end points were studied for comparison. For heavy ions, a dose of 2.0 Gy caused 100% pre-weaning mortality. For some endpoints, such as pre-weaning mortality, testis weight, and ratio of testis weight to body weight, significant alteration was observed in offspring prenatally received only 0.1 Gy of accelerated neon ions; while for the most endpoints regarding the effects from carbon ions or X rays, a significant alteration could be observed only when a dose was at 0.5 Gy or more. In this dose range, apoptosis in gonocytes of fetal gonads was significantly induced in a dose-dependent manner with a peak at around 12 to 18 hr after irradiation; in the prenatally irradiated pups, statistical significances for increased prenatal death, delayed accomplishment in testis descent, low testis weight, changed ratios of testis weight to body weight, and increased malformed testicular tubules were recorded. When the dose was at 1.0 Gy or 1.5 Gy, marked decrease in successful mating rates was also observed for the prenatally irradiated male rats with the non-irradiated female rats. On the other hand, for the animals descended from both the prenatally irradiated male rats and the non-irradiated female rats, significant increase in prenatal death and in pre-weaning mortality was scored when the father rats were prenatally irradiated with 0.5 Gy or more. These findings indicated that prenatal irradiations on gestation day 15 generally induced markedly detrimental effect on fetal development, postnatal testicular maturation and male reproductivity in rats, which was a dose and Let-related event. (author)

  4. Testicular development and reproductivity in rats

    International Nuclear Information System (INIS)

    Effects on gonads in prenatal male fetuses, and on the postnatal testicular development and reproductivity of male offspring were studied following exposure of pregnant Wistar rats to either accelerated carbon-ion beans with a Let value of about 13 keV/L]m or neon-ion beams with a Let value of about 30 keV/I Im at a dose range from 0.1 Gy to 2.0 Gy on gestation day 15. Induction of apoptosis in fetal gonocytes was evaluated pathologically in male gonads. Mean number of pups, pre-weaning mortality, and the age for testis descent in offspring were examined. Testis weight and the ratio of it to body weight were measured on postnatal days 30, 60 and 90, respectively. Development of testicular tubules was analyzed histologically. In addition, in the male offspring, the successful mating rates with non-irradiated female rats, the mean number of pups descended, and, the weaning rates of the pups were investigated. The effects of X-rays at 200 kVp estimated for the same biological end points were studied for comparison. For heavy ions, a dose of 2.0 Gy caused 100% pre-weaning mortality. For some endpoints, such as pre-weaning mortality, testis weight, and ratio of testis weight to body weight, significant alteration was observed in offspring prenatally received only 0.1 Gy of accelerated neon ions; while for the most endpoints regarding the effects from carbon ions or X rays, a significant alteration could be observed only when a dose was at 0.5 Gy or more. In this dose range, apoptosis in gonocytes of fetal gonads was significantly induced in a dose-dependent manner with a peak at around 12 to 18 hr after irradiation; in the prenatally irradiated pups, statistical significances for increased prenatal death, delayed accomplishment in testis descent, low testis weight, changed ratios of testis weight to body weight, and increased malformed testicular tubules were recorded. When the dose was at 1.0 Gy or 1.5 Gy, marked decrease in successful mating rates was also observed for the prenatally irradiated male rats with the non-irradiated female rats. On the other hand, for the animals descended from both the prenatally irradiated male rats and the non-irradiated female rats, significant increase in prenatal death and in pre-weaning mortality was scored when the father rats were prenatally irradiated with 0.5 Gy or more. These findings indicated that prenatal irradiations on gestation day 15 generally induced markedly detrimental effect on fetal development, postnatal testicular maturation and male reproductivity in rats, which was a dose and Let-related event. (author)

  5. Multiple vascular anomalies involving testicular, suprarenal arteries and lumbar veins

    Directory of Open Access Journals (Sweden)

    P Jyothsna

    2012-01-01

    Full Text Available Testicular arteries arise from the abdominal aorta and the inferior suprarenal artery from the renal artery. There are reports about variant origin and course of these arteries. Accessory testicular artery is also a common finding but its providing origin to inferior suprarenal artery is an important observation. During a routine dissection of abdomen of approximately 55-year-old male cadaver, unique vascular abnormality was observed. On the left side, a common arterial trunk originating from abdominal aorta immediately branched to give rise to superior testicular and inferior suprarenal arteries, the former after a short course hooked by the left suprarenal vein. In addition, the left suprarenal vein, second left lumbar vein, and left testicular vein joined to form a common trunk which drained into the left renal vein. A sound knowledge of vascular variations in relation to the kidney and suprarenal gland is important to surgeons dissecting the abdominal cavity.

  6. What Are the Risk Factors for Testicular Cancer?

    Science.gov (United States)

    ... that leads to both testicular cancer and abnormal positioning of one or both testicles. Orchiopexy may reduce ... Atlas Global Health Finish the Fight Press Room Mobile Site Help Site Map Privacy Accessibility Terms of ...

  7. Transverse testicular ectopia, a case report and review of literature

    Directory of Open Access Journals (Sweden)

    Moslemi, Mohammad Kazem

    2011-01-01

    Full Text Available Crossed testicular ectopia (CTE/transverse testicular ectopia (TTE is a rare but well known congenital anomaly, in which both gonads migrate toward the same hemiscrotum. It is usually associated with other abnormalities such as persistent Mullerian duct syndrome, true hermaphroditism, inguinal hernia, hypospadias, pseudohermaphroditism, and scrotal anomalies. About 100 cases of transverse testicular ectopia have been reported in published studies. We report a case of transverse testicular ectopia in an 8-month-old boy who presented with right inguinal hernia and nonpalpable left testis. On exploration, both testes were present in the right inguinal region. Bilateral orchiopexy was performed by crossing the left testis in the extra-peritoneal space and ipsilateral scrotal orchiopexy. The diagnosis could not be made preoperatively in most of reported cases.

  8. Reversible harmless interruption of testicular blood supply in the ram

    International Nuclear Information System (INIS)

    An effective method of interrupting testicular blood flow temporarily and repeatedly in the ram has been developed. Blockade of flow has been achieved mechanically by an inflatable occluder placed around the testicular artery at the level of the spermatic cord. The effect of the blockade on total testicular blood supply was investigated using Doppler flowmetry and a percutaneous Xenon-133 injection method. With both approaches, the blood flow changes after inflation or deflation of the occluders could be estimated satisfactorily. A substantial decrease of testicular blood flow was achieved in eight of the 10 testes with inflated occluders. However, there were indications that in the remaining two testes blockade of the arterial flow was not complete. After deflation of the occluders, blood flow was restored rapidly and completely in all testes. Macro- and microscopic examinations revealed no long-term damage to the testis after blood flow interruptions lasting 30 or 60 minutes

  9. Control químico del Nematodo quiste Heterodera trifolii en clavel miniatura Chemical control of the cyst nematode, Heterodera trifolii in miniature carnation

    OpenAIRE

    Marroquin Alicia; Arbelaez Germán

    1991-01-01

    Una de las enfermedades en el cultivo del clavel recientemente registradas en Colombia es el nemátodo quiste, Heterodera trifolii. Un aumento del marchitamiento vascular ocasionado por Fusarium oxysporumof. sp. dianthi se ha observado en algunas fincas afectadas por los dos patógenos. La investigación se realizó para evaluar el efecto de varios productos químicos en el control del nemátodo, en un invernadero comercial con clavel miniatura de la variedad Red Baron. Los fumigantes DD-metilisoti...

  10. Quiste hidatídico cerebral en niños en el Hospital Nacional Cayetano heredia: a propósito de un caso

    OpenAIRE

    Daniel Guillén; Patricia Campos; Ildauro Aguirre; Daniel Porturas; Noriega Pedro; Marcos Alva; Alfredo Fuentes-Dávila; Wesley Alaba

    1994-01-01

    Se presenta el caso de una niña de 12 años de edad con siete meses de evolución de signos focales e hipertensión endocraneana progressiva. Con ayuda de la TAC se diagnosticó tumoración quística gigante compatible a hidatidosis cerebral. Se realizó craneotomía y extirpación del quiste sin complicaciones. La hidatidosis cerebral es rara, su diagnóstico es clínico-tomográfico y el tratamiento siempre es quirúrgico.

  11. Quiste dermoide paratesticular: Aportación de un caso y revisión de la literatura / Paratesticular dermoid cyst: Presentation of one case and bibliographic revision

    Scientific Electronic Library Online (English)

    J.I., Luque Arana; C., Salas Antón; J.A., Diez Diez; L., Menéndez Ondina; J., Carballido Rodríguez.

    2003-03-01

    Full Text Available Se presenta un caso de un quiste dermoide que depende de las estructuras paratesticulares, entidad clínica de baja frecuencia de presentación. Se analiza la controvertida terminología de estos tumores y se establecen los criterios anatomopatológicos de esta enfermedad que preside el diagnóstico. [...] Abstract in english It is discussed a dermoid cyst case thath depends on paratesticular structures, clinical entity which has low frecuency of presentation. It is analyced the controversial terminology of this tumours and are established anatomopathological criteria for this disease. [...

  12. Tratamiento de quiste dentígero bilateral mandibular por medio de dos tipos de tratamientos: Relato de caso clínico y comparación entre las técnicas

    Scientific Electronic Library Online (English)

    Marvis E, Allais de Maurette; Paul E, Maurette O’Brien; Francisco, Haiter-Neto; Márcio, de Moraes.

    2007-01-01

    Full Text Available Os cistos dentígeros são o segundo tipo mais comun de lesão cística de desenvolvimento na mandíbula e tem sido associado com a retenção dos terceiros molares. São poucos os relatos de cistos dentígeros bilaterais ou multiplos em pacientes não sindrómicos. Seu tratamento pode ser por meio de enucleaç [...] ão ou descompresão e esta determinado principalmente pelo tamanho da lesão. Algun trabalhos relatam o tratamento dos cistos dentígeros porém não encontramos na literatura nenhum comparando ambos os tratamentos. Neste trabalho relatamos um caso de cisto dentígero bilateral num paciente não sindrómico onde se realizou como tratamento, do lado esquerdo descompresão e do lado direito enucleação, com un acompanhamento pós-operatório de 5 anos consecutivos, sem observar recidiva da lesão. Abstract in spanish Los quistes dentígeros son el segundo tipo mas común de lesión quística de desarrollo en la mandíbula y han sido asociados con la retención de los terceros molares. Son pocos los reportes sobre quistes dentígeros bilaterales o múltiples en pacientes no sindrómicos. Su tratamiento puede ser por medio [...] de la enucleación o descompresión y este es determinado principalmente por el tamaño de la lesión. Algunos artículos hablan del tratamiento de los quistes dentígeros pero no encontramos en la literatura ninguno comparando ambos tratamientos. En este artículo reportamos un caso de quiste dentígero bilateral en un paciente no sindrómico en el cual se realizó como tratamiento, del lado izquierdo descompresión y del lado derecho enucleación, con un acompañamiento posterior de 5 años consecutivos, sin observarse recidiva de la lesión. Abstract in english Dentigerous cyst are the second most common developmental cyst of the jaws and its been associated with impacted third molar teeth. Its rare reports about bilateral or multiple dentigerous cysts in nonsyndromic patients. They treatment can be enucleation or decompression and must be predicated upon [...] the size of lesion. Some articles talk about treatment of dentigerous cyst but we don’t find any one comparing both treatments. Here, we report a case of bilateral nonsyndromic dentigerous cyst comparing the treatment decompression vs. enucleation and follow up for 5 years, without recurrence.

  13. Quiste del colédoco como causa de dolor abdominal: revisión de un caso y bibliografía

    Directory of Open Access Journals (Sweden)

    Laura Arroyo Martínez

    2004-09-01

    Full Text Available El quiste del colédoco se define como la dilatación congénita o combinada del árbol biliar extrahepático (tipo más frecuente o intrahepático. La etiología no está aún determinada, pero existen tres teorías. Esta patología se observa en niños y adultos, predominantemente en mujeres. Pueden manifestarse anomalías en todo el sistema biliar, ya sea intra o extrahepático. Se clasifica en 5 tipos. Antes, el abordaje de dichos quistes era la cistoentero anastomosis, pero ahora se recomienda realizar una escisión completa del quiste, para disminuir el riesgo de malignidad y desarrollo de colangitis o pancreatitis recurrente. Aquí se presenta el caso de una mujer de 21 años con dolor abdominal, ictericia y una masa en el hipocondrío derecho, secundario a dicha patología, que fue sometida a una resección quirúrgica con anastomosis primaria. La evaluación anatomopatológica demostró una estructura quística de aspecto similar a una vesícula biliar, congestiva y pardusca, con inflamación crónica leve. Tuvo un postoperatorio satisfactorio y egresó con tratamiento antibiótico. El quiste coledociano debe considerarse en el diagnóstico diferencial de aquellos pacientes con dolor abdominal y masa en el cuadrante.Choledochal cyst is a dilatation of a component of the biliary tree and it may include both intra and extrahepatic sites. They are classified into five types, all of which are relatively rare. Previously, choledochal cysts were treated with biliaryenteric bypass procedures. The current recommendation is to attempt their complete excision to minimize the known risk of fecoming malignant and the development of recurrent cholangitis or pancreatitis that may occur in these patients. We present here the case of a 21 year old woman with abdominal pain and jaundice due to a type 1 choledochal cyst. The cyst was removed and patient did fine.

  14. Adverse testicular effects of Botox® in mature rats

    International Nuclear Information System (INIS)

    Botox® injections are taking a consistently increasing place in urology. Intracremasteric injections, particularly, have been applied for cryptorchidism and painful testicular spasms. Studies outlining their safety for this use are, however, scanty. Thus, the present study aimed at evaluating possible testicular toxicity of Botox® injections and their effect on male fertility. Mature rats were given intracremasteric Botox® injections (10, 20 and 40 U/kg) three times in a two-week interval. Changes in body and testes weights were examined and gonadosomatic index compared to control group. Semen quality, sperm parameters, fructose, protein, cholesterol and triglycerides contents were assessed. Effects on normal testicular function were investigated by measuring testosterone levels and changes in enzyme activities (lactate dehydrogenase-X and acid phosphatase). To draw a complete picture, changes in oxidative and inflammatory states were examined, in addition to the extent of connective tissue deposition between seminiferous tubules. In an attempt to have more accurate information about possible spermatotoxic effects of Botox®, flowcytometric analysis and histopathological examination were carried out. Botox®-injected rats showed altered testicular physiology and function. Seminiferous tubules were separated by dense fibers, especially with the highest dose. Flowcytometric analysis showed a decrease in mature sperms and histopathology confirmed the findings. The oxidative state was, however, comparable to control group. This study is the first to show that intracremasteric injections of Botox® induce adverse testicular effects evidenced by inhibited spermatogenesis and initiation of histopathological changes. In conclusion, decreased fertility may be a serious problem Botox® injections could cause. - Highlights: • Botox® injections are the trend nowadays, for both medical and non-medical uses. • They were recently suggested for cryptorchidism and testicular spasms. • This study outlines possible testicular adverse effects of these injections. • Botox® affected normal testicular function and physiology. • Infertility is a serious problem that Botox® injections could cause

  15. Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence

    OpenAIRE

    Hu, Guo-xin; Lian, Qing-Quan; Ge, Ren-Shan; Hardy, Dianne O.; Li, Xiao-Kun

    2009-01-01

    Phthalates, the most abundantly produced plasticizers, leach out from polyvinyl chloride plastics and disrupt androgen action. Male rats that are exposed to phthalates in utero develop symptoms characteristic of the human condition referred to as testicular dysgenesis syndrome (TDS). Environmental influences have been suspected to contribute to the increasing incidence of TDS in humans (i.e. cryptorchidism and hypospadias in newborn boys and testicular cancer and reduced sperm quality in adul...

  16. Simultaneous ipsilateral testicular seminoma with pelvic ectopy and hematovesicula seminalis

    OpenAIRE

    Hadži-Đokić Jovan; Andrejević Vladan; Đurasić Ljubomir; Aćimović Miodrag; Petrović Milan; Pejčić Tomislav; Džamić Zoran

    2012-01-01

    We present a rare case of 24 years old male who was diagnosed with simultaneous testicular tumor with pelvic ectopy and ipsilateral hematovesicula seminalis. Hemospermia was the only presented symptom. Patient underwent surgery and removal of the testicular tumor and right vesiculectomy were performed.Histopathological analysis revealed seminoma of the right testis and dilated right vesicula seminalis filled with hemorrhagic fluid and sings of chronic inflammation. Postoperatively irrad...

  17. Varicocele Repair Improves Testicular Histology in Men with Nonobstructive Azoospermia

    OpenAIRE

    Murat Ustuner; Hasan Yilmaz; Ufuk Yavuz; Seyfettin Ciftci; Ali Saribacak; Bahri Serkan Aynur; Hikmet Yasar; Mustafa Melih Culha

    2015-01-01

    Objective. To determine the histopathological differences after varicocele repair in testicular tissue in males with nonobstructive azoospermia. Methods. Between 2009 and 2014, 45 men with complete azoospermia and palpable varicocele, presenting with primary infertility of at least 1 year, undergoing varicocele repair at our institution were selected for the study. A standard systematic testicular 6-core Tru-Cut biopsy was performed during varicocele repair. Other biopsies were obtained from ...

  18. Adverse testicular effects of Botox® in mature rats

    Energy Technology Data Exchange (ETDEWEB)

    Breikaa, Randa M. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt); Mosli, Hisham A. [Department of Urology, Faculty of Medicine, King Abdulaziz University, Jeddah (Saudi Arabia); Nagy, Ayman A. [Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah (Saudi Arabia); Department of Forensic Medicine and Toxicology, Faculty of Medicine, Tanta University, Tanta (Egypt); Abdel-Naim, Ashraf B., E-mail: abnaim.pharma@gmail.com [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt); Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah (Saudi Arabia)

    2014-03-01

    Botox® injections are taking a consistently increasing place in urology. Intracremasteric injections, particularly, have been applied for cryptorchidism and painful testicular spasms. Studies outlining their safety for this use are, however, scanty. Thus, the present study aimed at evaluating possible testicular toxicity of Botox® injections and their effect on male fertility. Mature rats were given intracremasteric Botox® injections (10, 20 and 40 U/kg) three times in a two-week interval. Changes in body and testes weights were examined and gonadosomatic index compared to control group. Semen quality, sperm parameters, fructose, protein, cholesterol and triglycerides contents were assessed. Effects on normal testicular function were investigated by measuring testosterone levels and changes in enzyme activities (lactate dehydrogenase-X and acid phosphatase). To draw a complete picture, changes in oxidative and inflammatory states were examined, in addition to the extent of connective tissue deposition between seminiferous tubules. In an attempt to have more accurate information about possible spermatotoxic effects of Botox®, flowcytometric analysis and histopathological examination were carried out. Botox®-injected rats showed altered testicular physiology and function. Seminiferous tubules were separated by dense fibers, especially with the highest dose. Flowcytometric analysis showed a decrease in mature sperms and histopathology confirmed the findings. The oxidative state was, however, comparable to control group. This study is the first to show that intracremasteric injections of Botox® induce adverse testicular effects evidenced by inhibited spermatogenesis and initiation of histopathological changes. In conclusion, decreased fertility may be a serious problem Botox® injections could cause. - Highlights: • Botox® injections are the trend nowadays, for both medical and non-medical uses. • They were recently suggested for cryptorchidism and testicular spasms. • This study outlines possible testicular adverse effects of these injections. • Botox® affected normal testicular function and physiology. • Infertility is a serious problem that Botox® injections could cause.

  19. Polychlorinated biphenyls and risk of testicular germ cell tumors

    OpenAIRE

    McGlynn, Katherine A.; Quraishi, Sabah M; Barry I. Graubard; Weber, Jean-Philippe; Rubertone, Mark V.; Erickson, Ralph L

    2009-01-01

    Exposure to endocrine disrupting chemicals, such as polychlorinated biphenyls (PCBs), may alter hormonal balance and thereby, increase risk of testicular germ cell tumors (TGCT). To study the relationship of PCBs to TGCT, pre-diagnostic serum samples from 736 cases and 913 controls in the Servicemen’s Testicular Tumor Environmental and Endocrine Determinants study were analyzed. Adjusted odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using logistic regression. PCB levels...

  20. Adenocarcinoma of the stomach following radical radiotherapy for testicular cancer

    International Nuclear Information System (INIS)

    Two male patients who underwent curative surgery and adjuvant radiotherapy (with further chemotherapy in one) for testicular cancer developed adenocarcinoma of the stomach 5 and 19 years after treatment. The stomach is included in the field of radiotherapy used to treat the para-aortic lymph nodes and this may lead to dysplastic changes in the stomach mucosa which can lead to frank malignancy. Early endoscopy should be offered to patients with dyspeptic symptoms after adjuvant radiotherapy for testicular cancer. (author)

  1. Retroperitoneal fibrosis following radiotherapy for stage I testicular seminoma.

    Science.gov (United States)

    Moul, J W

    1992-01-01

    Retroperitoneal fibrosis, proved by surgical exploration and pathology, was discovered in a patient 13 years after 3,000 rad external beam cobalt retroperitoneal radiation therapy for stage I testicular seminoma. Ureteral obstruction resulted in the loss of 1 kidney, necessitating ipsilateral nephrectomy and contralateral ureterolysis. To my knowledge this is the first reported case of retroperitoneal fibrosis occurring after radiotherapy for testicular cancer. PMID:1729501

  2. The Role of Androgens in Testicular Development and Dysgenesis

    OpenAIRE

    Scott, Hayley M.

    2007-01-01

    Disorders of male reproductive health which manifest at birth (cryptorchidism, hypospadias) or in young adulthood (testicular germ cell cancer and low sperm counts), are common and may be increasing in incidence. These disorders have a common fetal origin and share risk factors; consequently they are hypothesized to comprise a testicular dysgenesis syndrome (TDS). TDS arises when maldevelopment (dysgenesis) of the fetal testis results in hormonal malfunctions and abnormal de...

  3. Testicular and vascular changes in children and adults with varicocele.

    Science.gov (United States)

    Hadziselimovic, F; Herzog, B; Liebundgut, B; Jenny, P; Buser, M

    1989-08-01

    We analyzed bilateral testicular biopsies of 188 infertile patients with idiopathic left varicocele. The left side had significant pathological tubular testicular changes compared to the right side, whereas in only 7 per cent of the patients tubular damage was more pronounced on the right side. The Leydig cell pathological score was identical in both testes in 95 per cent of the patients. However, the lower the Leydig cell pathological score the better the testicular histology, suggesting an association between Leydig cell score and testicular function. Of the 188 patients 11 boys and 8 adults were randomly selected, and they displayed clear endothelial proliferative lesions of the capillaries at the ultrastructural level. Proliferative endothelial lesions in the patients with varicocele preceded the testicular changes. This, together with the prevalence of tubular damage at the site of the varicocele and the reversibility of these changes postoperatively, emphasizes the deleterious effects of varicocele as a cause of infertility in these patients. Early surgery for boys in whom the first signs of testicular atrophy occur is highly recommended. PMID:2746782

  4. Quiste branquial tipo I: presentación de un caso / A type-I brachial cyst: a case report

    Scientific Electronic Library Online (English)

    Fidel, Castro Pérez; Raúl, Rodríguez González; Juan M, Flores Contreras; Vivian, Álvarez Díaz; María de las Nieves, Cordero Ledesma.

    2010-12-01

    Full Text Available Se presenta el caso de una adolescente de 14 años de edad, raza blanca, del sexo femenino, con antecedentes de salud relativa, que se valoró en la consulta externa del Policlínico Universitario Ernesto Guevara de la Serna de Sandino, Pinar del Río, Cuba. La paciente presentó un cuadro caracterizado [...] por el aumento de volumen superficial de la región lateral derecha superior del cuello, por debajo de la rama horizontal de la mandíbula y por delante del borde anterior del músculo esternocleidomastoideo, cerca del pabellón auricular y la parótida, de aproximadamente 4 cm. de diámetro, móvil, no doloroso, de superficie lisa y consistencia renitente, sin cambios en la coloración de la piel; al examen físico otorrinolaringológico no se encontraron otras alteraciones, posteriormente se realizó un ultrasonido en esa región. El diagnóstico dio como resultado un quiste branquial y se procedió a la exéresis quirúrgica por el equipo de autores del artículo, realizándose estudio anatomopatológico. Los autores presentan las experiencias derivadas de la atención del caso, y revisan la literatura médica sobre el tema con especial referencia al diagnóstico y tratamiento. Abstract in english A Caucasian 14 year-old female adolescent having relative health history was assessed at "Ernesto Guevara de la Serna" Outpatient Clinic in Sandino, Pinar del Rio, Cuba. The patient presented a clinical chart which was characterized by an increase of the superficial volume of the right upper lateral [...] region of neck, below the horizontal branch of the mandible and to the front of the anterior border of sternocleidomastoid muscle, near outer ear and parotid having approximately 4cm of diameter, motile, painless, smooth surface and renitent consistency, without changes in skin color; physical and ENT examinations found no other alterations, subsequently a sonographic study in that region confirmed a brachial cyst that was surgically removed performing pathological studies. The authors presented the experiences derived from this case and the medical literature about the topic was reviewed emphasizing on the diagnosis and treatment.

  5. Quiste hidatídico pulmonar roto en un escolar de Calama Ruptured hydatid cyst in a schoolchild from Calama

    Directory of Open Access Journals (Sweden)

    Carlos Briones B

    2004-05-01

    Full Text Available La hidatidosis es una zoonosis cuya frecuencia en Chile varía según el área geográfica. El desierto de Atacama tiene características que hacen raro el desarrollo de esta patología, que a la vez, se presenta con características particulares en la infancia. Reportamos la evolución clínica de una escolar de Calama, de 6 años de edad, que presentó compromiso del estado general, fiebre, y anorexia de 5 días de evolución, a lo que se agregó tos persistente con episodios asficticos y vómica de material blanco grisáceo, hemoptoico y filante, sin mal olor, asociado a dolor punzante en hemitórax derecho y dificultad respiratoria progresiva. La radiografía de torax y TAC pulmonar muestran imagen compatible con quiste hidatídico basal derecho y la serología ELISA para hidatidosis resultó (+. Se trató con albendazol por 17 días y se realizó quistectomía con capitonaje, sin complicaciones posteriores. Comentamos la forma de presentación, los factores de riesgo y el tratamiento de la patología, basados en una revisión de la literatura y la experiencia nacionalHydatid disease is a zoonosis which has a varying incidence in Chile according to the geographic location. The Atacama desert has features which make this disease uncommon and likewise presents with special features during childhood. We report the clinical evolution of a 6 year old schoolgirl with pulmonary hydatid disease. Commenting on the presentation, risk factors and treatment, based on a review of the literature and national experience

  6. Testicular atrophy secondary to a large long standing incarcerated inguinal hernia

    Directory of Open Access Journals (Sweden)

    Nikolaos S Salemis

    2011-09-01

    Full Text Available Testicular atrophy is a rare but distressing complication of inguinal hernia repair. Apart from the postsurgical etiology, ischemic orchitis and subsequent testicular atrophy may occur secondary to compression of the testicular vessels by chronically incarcerated hernias. We present a rare case of testicular atrophy secondary to a large long standing incarcerated inguinal hernia of 2-decade duration in a 79-year-old man. Testicular atrophy should be always considered in long standing incarcerated inguinal hernias and patients should be adequately informed of this possibility during the preoperative work-up. Preoperative scrotal ultrasonography can be used to determine testicular status in this specific group of patients.

  7. Quiste dentígero asociado con mesiodens: Exposición de un caso, revisión de la literatura y diagnóstico diferencial Dentigerous cyst associated with mesiodens: a case report, literature review and differential diagnostic

    Directory of Open Access Journals (Sweden)

    F.J. Rodríguez Romero

    2011-12-01

    Full Text Available El quiste dentígero es uno de los quistes odontogénicos más frecuentes y están asociados con la corona de un diente no erupcionado o en desarrollo. Cuando se asocian con dientes supernumerarios son poco frecuentes y constituyen el 5-6% de todos los quistes dentígeros. En región maxilar, el 90% de los casos se asocian a mesiodens. El objetivo de este artículo es exponer el caso de una adolescente de 14 años con un quiste dentígero asociado con un diente supernumerario (mesiodens impactado en región maxilar anterior, su manejo dental y revisión de la literatura.Dentigerous cyst is one of the most prevalent types of odontogenic cyst and is associated with crown of an unerupted or developing tooth. Dentigerous cysts associated with supernumerary teeth are rare and estimated to constitute 5-6% of all dentigerous cysts. The vast majority, about 90%, are associated with a maxillary mesiodens. The purpose of this article to report the case of an 14-year-old a teenager with a dentigerous cyst associated with an impacted anterior maxillary supernumerary tooth, its dental management and literature review.

  8. Quiste dentígero asociado con mesiodens: Exposición de un caso, revisión de la literatura y diagnóstico diferencial / Dentigerous cyst associated with mesiodens: a case report, literature review and differential diagnostic

    Scientific Electronic Library Online (English)

    F.J., Rodríguez Romero; S., Cerviño Ferradanes; P., Muriel Cueto.

    2011-12-01

    Full Text Available El quiste dentígero es uno de los quistes odontogénicos más frecuentes y están asociados con la corona de un diente no erupcionado o en desarrollo. Cuando se asocian con dientes supernumerarios son poco frecuentes y constituyen el 5-6% de todos los quistes dentígeros. En región maxilar, el 90% de lo [...] s casos se asocian a mesiodens. El objetivo de este artículo es exponer el caso de una adolescente de 14 años con un quiste dentígero asociado con un diente supernumerario (mesiodens) impactado en región maxilar anterior, su manejo dental y revisión de la literatura. Abstract in english Dentigerous cyst is one of the most prevalent types of odontogenic cyst and is associated with crown of an unerupted or developing tooth. Dentigerous cysts associated with supernumerary teeth are rare and estimated to constitute 5-6% of all dentigerous cysts. The vast majority, about 90%, are associ [...] ated with a maxillary mesiodens. The purpose of this article to report the case of an 14-year-old a teenager with a dentigerous cyst associated with an impacted anterior maxillary supernumerary tooth, its dental management and literature review.

  9. Enucleación de quiste periapical simultáneo a la obturación del sistema de conductos radiculares / Periapical cyst enucleation and simultaneous sealing of the root canal system

    Scientific Electronic Library Online (English)

    Lida, Velazque; Alexandre, Simões-Nogueira; Ilan, Sampaio do Vale; Victor, Tiegui Neto; Andrea, Guedes Barreto Gonçales; Eduardo, Sánches Gonçales.

    2014-06-01

    Full Text Available Introducción: los quistes periapicales representan el tipo más frecuente dentro de los quistes odontogénicos. Su origen está relacionado con una necrosis pulpar y un consecuente estímulo de los restos epiteliales del ligamento periodontal (Malassez). Objetivo: describir un caso clínico de enucleació [...] n de quiste periapical simultáneo a la obturación del sistema de conductos radiculares. Presentación del caso: paciente de sexo femenino, 67 años de edad, sin alteraciones sistémicas; buscó atención odontológica por presentar dolor dental y acúmulo de alimentos en la región de molares inferiores del lado izquierdo. Al examen clínico se observó caries extensa en el segundo molar inferior izquierdo con compromiso de furca, ausencia de aumento de volumen vestibular, sin fistula; en la radiografía periapical se evidenció lesión cariosa extensa recidivante en el segundo molar inferior izquierdo, y primer molar inferior izquierdo con tratamiento endodóntico y presencia de área radiolúcida de contornos bien definidos en la región periapical compatible con quiste periapical. El tratamiento estuvo a cargo de un equipo multidisciplinario por lo que se decidió realizar exodoncia del segundo molar inferior izquierdo y cirugía paraendodóntica con enucleación quirúrgica simultánea a la obturación del sistema de conductos radiculares primer molar inferior izquierdo; el examen histopatológico de la muestra extraída comprobó tratarse de un quiste periapical. Se realizó seguimiento radiográfico dos años después y mostró un completo reparo óseo del área afectada. Conclusiones: se concluye que el tratamiento descrito constituye una alternativa válida para la resolución de casos donde la endodoncia convencional es limitada para mantener la función y estética de una pieza dentaria. Abstract in english Introduction: periapical cysts are the most common odontogenic cysts. Their origin is related to pulp necrosis and the consequent stimulation of epithelial rests of the periodontal ligament (Malassez). Objective: describe a clinical case of periapical cyst enucleation and simultaneous sealing of the [...] root canal system. Case report: a female 67-year-old patient without any systemic alteration sought care for dental pain and accumulation of food in the area of the lower left molars. Clinical examination revealed extensive decay in the lower left second molar with furcation involvement and absence of vestibular volume increase without a fistula. Periapical radiography showed an extensive recurrent carious lesion in the lower left second molar and lower left first molar with endodontic treatment and presence of a radiolucent area of a sharp outline in the periapical region compatible with periapical cyst. Treatment was conducted by a multidisciplinary team, who decided to perform extraction of the lower left second molar and paraendodontic surgery with surgical enucleation and simultaneous sealing of the root canal system in the lower left first molar. Histopathological examination of the specimen removed revealed it was a periapical cyst. Radiographic follow-up conducted two years later showed complete bone repair in the affected area. Conclusions: it is concluded that the treatment described is a valid alternative for the resolution of cases in which conventional endodontics is insufficient to preserve the function and aesthetic appearance of a tooth.

  10. Comportamiento del quiste branquial en pacientes del Hospital General Docente "Ciro Redondo García", Artemisa, 1993-2009 Behavior of branchial cyst in patients admitted in the "Ciro Redondo García", General Teaching Hospital, Artemisa municipality, 1993-2009

    OpenAIRE

    Juan Carlos Quintana Díaz; Josefa Dolores Miranda Tarragó; Mayrim Quintana Giralt

    2012-01-01

    El quiste branquial de origen congénito que aparece en la región lateral del cuello es, con frecuencia, motivo de consulta. Se tuvo como objetivo determinar el comportamiento de los quistes branquiales en el Hospital "Ciro Redondo García", de Artemisa en el periodo de 1993 al 2009. Se realizó un estudio descriptivo transversal de los quistes branquiales diagnosticados en pacientes intervenidos quirúrgicamente en el Servicio de Cirugía Maxilofacial. Se estudiaron la edad, el sexo, el color de ...

  11. Manejo multidisciplinario en la recidiva de carcinoma epidermoide de conducto auditivo externo. Presentación de un caso Multidisciplinary handling of epidermoid carcinoma in the external auditory canal. Presentation of a case

    Directory of Open Access Journals (Sweden)

    Misleidy Nápoles Morales

    2011-06-01

    Full Text Available Se presenta un paciente de 42 años con el diagnóstico de un carcinoma epidermoide bien diferenciado de conducto auditivo externo (CAE, diagnosticado en junio de 2008. El mismo recibió radioterapia como tratamiento con intención curativa a dosis radical 66 Gy. En enero de 2010, comenzó con aumento de volumen exagerado del conducto auditivo externo, discutiéndose en los servicios de Neurocirugía, Radioterapia y Cirugía Reconstructiva del Instituto Nacional de Oncología y Radiobiología. Al paciente se le realiza la exéresis total del tumor, una radioterapia intraoperatoria fraccionada con electrones (EIORT y reconstrucción local con colgajo músculo cutáneo del pectoral mayor. El tratamiento resultó ser tolerado por el paciente aumentándole su expectativa y calidad de vida.A 42 year-old patient is presented with the diagnostic of an Epidermoid Carcinoma of the external auditory canal on June 2008. He had got a radical radiotherapy as treatment with a completely response but in January 2010 he return with the tumour in the same place. It was the reason to discuss this patient in different department as Neurosurgery, Radiotherapy and Reconstructive Surgery. This patient received a total remove of the tumour, Intraoperative Radiotherapy with electron (EIORT and a local reconstruction with mayor Pectoral Muscle. As Result the treatments were bear by the patient increasing his expectative and quality life.

  12. [Testicular tissue vitrification: evolution or revolution?].

    Science.gov (United States)

    Wyns, C; Abu-Ghannam, G; Poels, J

    2013-09-01

    Preservation of reproductive health is a major concern for patient long-term quality of life. While sperm freezing has proven to be effective to preserve fertility after puberty, cryopreservation of immature testicular tissue (ITT) is emerging as a promising approach for fertility preservation in young boys. Slow-freezing (SF) is the conventional method used to preserve ITT and has resulted in the birth of mice offspring. In humans, methods to preserve ITT are still at the research stage. Controlled SF using dimethyl sulfoxide showed preservation of proliferative spermatogonia after thawing in a xenotransplantation model used to evaluate the efficiency of freezing and thawing procedures. However, spermatogonial recovery was low and normal differentiation could not be achieved. Both freezing/thawing and the environment of the xenotransplantation model may be implicated. Indeed, with SF, ice crystal formation could damage tissue and cells. For this reason, vitrification, leading to solidification of a liquid without crystallization, may be a promising alternative. ITT vitrification has been investigated in different species and shown spermatogonial survival and differentiation to the round or elongated spermatids stage. Offspring were also recently obtained after vitrification and allotransplantation in avians, confirming the potential of vitrification for fertility preservation. In humans, vitrification appears to be as efficient as SF in terms of spermatogonial survival and initiation of differentiation after xenotransplantation. However, before validation of such fertility preservation methods, completion of normal spermatogenesis and the fertilization capacity of sperm retrieved from cryopreserved and transplanted tissue should be fully investigated. PMID:23958328

  13. Testicular tumors: oncologic imaging and diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Heiken, J.P.; Balfe, D.M.; McClennan, B.L.

    1984-02-01

    The extreme radiosensitivity of testicular seminomas plus recent advances in chemotherapy for nonseminomatous tumors and for advanced seminomas have made long term survival possible in the large majority of patients with testis cancer. Since choice of therapy is determined by tumor histology and extent of disease, accurate clinical staging is critical. Computed tomography (CT) of the abdomen and chest is the imaging procedure of choice for staging testis cancer. Clinical staging accuracy of 80 to 90% can be achieved using CT in combination with radio-immunoassays for ..beta..-HCG and AFP. Ultrasonography (US), while less sensitive and specific than CT for determining nodal status, may be useful in thin patients with sparse retroperitoneal fat. Lymphangiography should be reserved for Stage I patients in whom elective treatment of the retroperitoneum is not planned. Follow-up should include serial radioimmunoassays for serum AFP and ..beta..-HCG and periodic CT examinations of the abdomen and chest. In addition, nuclear magnetic resonance (NMR) imaging and radionuclide imaging following injection of radioactively labelled antibodies to AFP and ..beta..-HCG are new techniques which offer great promise for the future.

  14. Pattern of testicular biopies as seen in a tertiary institution in Nnewi, Southeast Nigeria

    Directory of Open Access Journals (Sweden)

    Chidi-Kingsley Oranusi

    2014-01-01

    Full Text Available Background: Testicular biopsy is an acknowledged method of examination of the testes for diagnostic and therapeutic purposes. We describe the pattern of testicular histologies in our environment. Materials and Methods: We carried out a retrospective review of testicular histology results from the Pathology Department of Nnamdi Azikiwe University Teaching Hospital (NAUTH, Nnewi, over a 5-year period, January 2008 to December 2012. Results: During the period, 285 testicular histologies were reported. Eighty-one (28.4% specimens were pathological specimens, while 204 (71.6% were nonpathological specimens. Thirty-seven (13.0% of the histology reports were for diagnostic purpose while 248 (87.0% were for therapeutic purpose. Based on the results, indications could also be categorized into three, benign testicular pathology, malignant testicular pathology, and testicular biopsy for male factor infertility. Thirty-seven cases (13.0% were due to male factor infertility with complete spermatogenic arrest as the most common histological finding in 21 (56.8% of the cases. Malignant testicular diseases accounted for 16 (5.6% of the indications for testicular biopsies. Benign testicular diseases accounted for 28 (9.8% of the indications for testicular biopsies. Hemorrhagic infarction from testicular torsion represented the commonest histology in 12 (42.9% cases, followed by inflammations of the testes. Conclusion: Indications for testicular biopsy can be diagnostic and therapeutic. They can also be categorized into benign testicular diseases, malignant testicular diseases, and male infertility. Investigation for male factor infertility was the only diagnostic indication for testicular biopsy. The high incidence of locally and metastatic prostate cancer in males explains why therapeutic removal of the testis is common.

  15. Effects of resveratrol on the proliferation, apoptosis and telomerase ability of human A431 epidermoid carcinoma cells

    Science.gov (United States)

    ZHAI, XIAO-XIANG; DING, JI-CUN; TANG, ZHI-MING; LI, JING-GUO; LI, YONG-CONG; YAN, YUE-HUA; SUN, JING-CHANG; ZHANG, CUI-XIA

    2016-01-01

    The aim of the present study was to investigate the effect of resveratrol on cell apoptosis, ability of telomerase and the human telomerase reverse transcriptase (hTERT) protein expression in human A431 epidermoid carcinoma cells. A431 cells were treated with different concentrations of resveratrol, and the cell appearance was then observed under a microscope. In addition, the cell proliferation was examined using an MTT assay, and the ability of telomerase was detected using telomeric repeat amplification protocol-polymerase chain reaction-ELISA. Resveratrol significantly inhibited the ability of telomerase and decreased the expression of hTERT protein in a concentration-dependent manner. In conclusion, resveratrol is capable of downregulating the expression of hTERT protein and inhibits the ability of telomerase of A431, which is an important mechanism of action of resveratrol with regard to inhibition of A431 cell proliferation.

  16. Internalization and intracellular distribution of epidermal growth factor and its receptor in epidermoid carcinoma cell line A431

    Energy Technology Data Exchange (ETDEWEB)

    Jagodzinski, P.P.; Jezewska, E.; Zeromski, J.; Trzeciak, W.H. [Polska Akademia Nauk, Poznan (Poland). Zaklad Genetyki Czlowieka]|[Akademia Medyczna, Poznan (Poland)

    1992-12-31

    The internalization and intracellular distribution of the epidermal growth factor (EGF) was investigated in the epidermoid carcinoma cell line A431. Confluent monolayer cultures were incubated with {sup 125}I-EGF and its distribution in sub cellar fractions cell homogenates, sub fractions of cell nuclei, and nuclear chromatin was determined. It was found that during incubation at 37 C the {sup 125}I-EGF accumulated in cell nuclei, where it was closely bound to chromatin. This was accompanied by translocation of EGF receptor into nuclei; as evidenced by immunostaining of EGF receptor. The accumulation of EGF in chromatin coincided with a dose dependent decrease in {sup 3}H-thymidine incorporation into DNA. The internalization of EGF/receptor complexes required continued protein synthesis, recycling of the receptor and was blocked by inhibition of cell respiration. (author). 13 refs, 6 figs, 1 tab.

  17. Quiste branquial tipo I: presentación de un caso A type-I brachial cyst: a case report

    Directory of Open Access Journals (Sweden)

    Fidel Castro Pérez

    2010-12-01

    Full Text Available Se presenta el caso de una adolescente de 14 años de edad, raza blanca, del sexo femenino, con antecedentes de salud relativa, que se valoró en la consulta externa del Policlínico Universitario Ernesto Guevara de la Serna de Sandino, Pinar del Río, Cuba. La paciente presentó un cuadro caracterizado por el aumento de volumen superficial de la región lateral derecha superior del cuello, por debajo de la rama horizontal de la mandíbula y por delante del borde anterior del músculo esternocleidomastoideo, cerca del pabellón auricular y la parótida, de aproximadamente 4 cm. de diámetro, móvil, no doloroso, de superficie lisa y consistencia renitente, sin cambios en la coloración de la piel; al examen físico otorrinolaringológico no se encontraron otras alteraciones, posteriormente se realizó un ultrasonido en esa región. El diagnóstico dio como resultado un quiste branquial y se procedió a la exéresis quirúrgica por el equipo de autores del artículo, realizándose estudio anatomopatológico. Los autores presentan las experiencias derivadas de la atención del caso, y revisan la literatura médica sobre el tema con especial referencia al diagnóstico y tratamiento.A Caucasian 14 year-old female adolescent having relative health history was assessed at "Ernesto Guevara de la Serna" Outpatient Clinic in Sandino, Pinar del Rio, Cuba. The patient presented a clinical chart which was characterized by an increase of the superficial volume of the right upper lateral region of neck, below the horizontal branch of the mandible and to the front of the anterior border of sternocleidomastoid muscle, near outer ear and parotid having approximately 4cm of diameter, motile, painless, smooth surface and renitent consistency, without changes in skin color; physical and ENT examinations found no other alterations, subsequently a sonographic study in that region confirmed a brachial cyst that was surgically removed performing pathological studies. The authors presented the experiences derived from this case and the medical literature about the topic was reviewed emphasizing on the diagnosis and treatment.

  18. Study on the incidence of testicular and epididymal appendages in patients with cryptorchidism

    Directory of Open Access Journals (Sweden)

    Favorito Luciano A.

    2004-01-01

    Full Text Available OBJECTIVE: To study the incidence of testicular and epididymal appendages in patients with cryptorchidism. MATERIALS AND METHODS: We studied 65 patients with cryptorchidism, totalizing 83 testes and 40 patients who had prostate adenocarcinoma and hydrocele (control group, totalizing 55 testes. The following situations were analyzed: I absence of testicular and epididymal appendages, II presence of testicular appendage only, III presence of epididymal appendage, IV presence of testicular and epididymal appendage, V presence of 2 epididymal appendages and 1 testicular appendage and VI presence of paradidymis or vas aberrans of Haller. RESULTS: In patients with cryptorchidism we found testicular appendages in 23 cases (41.8%, epididymal appendages in 9 (16.3%, testicular and epididymal appendage in 8 (14.5%, 2 epididymal appendages and 1 testicular in 1 (1.8% and absence of appendages in 14 (25.4%. In the control group, we found testicular appendages in 29 (34.9%, epididymal appendages in 19 (22.8%, testicular and epididymal appendage in 7 (8.4%, and absence of appendages in 28 (33.7%, we did not find 2 epididymal appendages in this group, and none of the patients in the 2 groups presented paradidymis or vas aberrans of Haller. CONCLUSION: The occurrence of testicular and epididymal appendages is quite variable. There was no statistically significant difference in the incidence and distribution of the testicular and epididymal appendages between patients with cryptorchidism and those from the control group.

  19. Tumores testiculares bilaterais por hiperplasia congênita de restos adrenais Bilateral testicular tumors caused by congenital adrenal rest hyperplasia

    Directory of Open Access Journals (Sweden)

    Virginia Oliveira Fernandes

    2009-11-01

    Full Text Available OBJETIVOS: Tumores testiculares são uma rara condição associada à hiperplasia adrenal congênita (HAC que decorrem da hiperplasia de restos adrenais intratesticulares (HRA, raramente ocorrendo associados a neoplasias malignas. Sua diferenciação histológica com tumores de células de Leydig é muito difícil, podendo levar a orquiectomias desnecessárias. O objetivo deste relato foi apresentar esse dilema diagnóstico em um paciente com HAC e tumores testiculares bilaterais. MÉTODOS: Relatou-se o caso de um paciente masculino, 16 anos, com diagnóstico de HAC desde os 3 anos de idade, que apresentava tumorações testiculares endurecidas, indolores e de crescimento lento, sendo encaminhado para orquiectomia bilateral. RESULTADOS: Foi decidido por tratamento conservador com prednisona, havendo significativa diminuição do volume testicular e normalização dos níveis de andrógenos. CONCLUSÃO: Este caso demonstra a importância de sempre se considerar a hipótese de HRA intratesticulares no diagnóstico diferencial dos tumores testiculares. A investigação e a conduta devem ser conduzidas de maneira cautelosa para se evitar orquiectomias desnecessárias.OBJECTIVES: Testicular tumors are a rare condition associated with congenital adrenal hyperplasia (CAH, originated from intratesticular adrenal rest tumors, and they are rarely associated with malignant tumors. Their histological differentiation from Leydig-cell tumors is quite difficult, which would lead to inappropriate orchiectomies. Thus the objective of this report was to present this diagnostic dilemma. METHODS: Reported the case of 16-yr-old boy with previous diagnosis of CAH with bilateral testicular enlargement who was recommended to be submitted to a bilateral orchiectomy. RESULTS: Considering this findings, it was decided to treat conventionally with prednisone with significant reduction of testicular volume, and normalization of androgens levels. CONCLUSION: This case shows the importance of intratesticular adrenal rest tumors in the differential diagnosis of testicular tumors. Cautious approach during investigation and treatment are recommended to avoid inappropriate orchiectomies.

  20. Studies on the influence of radiation and chemotherapy on pituitary-testicular axis in patients with testicular tumor

    Energy Technology Data Exchange (ETDEWEB)

    Ogawa, Katsuaki (Yokohama City Univ. (Japan). Faculty of Medicine)

    1982-02-01

    Radiation and chemotherapy have been known as the highly effective treatment of patients with testicular tumor. To evaluate the influences of the therapies on pituitary-testicular axis, plasma FSH, LH and testosterone were determined by radioimmunoassay in 60 patients with testicular tumor before and after 1 to 102 months in the completion of radiation and chemotherapy. The results were summarized as follows: 1) In 10 out of 24 patients, plasma FSH and LH levels significantly increased within 20 months after 2,100 - 4,500 rad/3 - 6 weeks of radiation therapy. 2) In combination chromotherapy popularly used for testicular tumor, plasma FSH and LH in 8 of 22 patients markedly elevated within 20 months after the treatment. 3) The elevated gonadotropins returned to normal levels in approximately 50 months in patients received radiation or chemotherapy. 4) Plasma testosterone revealed normal levels in any therapeutic programs employed in the present study. 5) From the results of Gn-RH test, the pituitary gland seemed to have normal function. 6) Plasma testosterone showed incomplete response to hCG stimulation after 1 to 35 months of radiation or chemotherapy. Therefore, it was suggested that radiation and chemotherapy for the treatment of testicular tumor may impair not only seminiferous tubules but also Leydig cell for a couple of years.

  1. Studies on the influence of radiation and chemotherapy on pituitary-testicular axis in patients with testicular tumor

    International Nuclear Information System (INIS)

    Radiation and chemotherapy have been known as the highly effective treatment of patients with testicular tumor. To evaluate the influences of the therapies on pituitary-testicular axis, plasma FSH, LH and testosterone were determined by radioimmunoassay in 60 patients with testicular tumor before and after 1 to 102 months in the completion of radiation and chemotherapy. The results were summarized as follows: 1) In 10 out of 24 patients, plasma FSH and LH levels significantly increased within 20 months after 2,100 - 4,500 rad/3 - 6 weeks of radiation therapy. 2) In combination chromotherapy popularly used for testicular tumor, plasma FSH and LH in 8 of 22 patients markedly elevated within 20 months after the treatment. 3) The elevated gonadotropins returned to normal levels in approximately 50 months in patients received radiation or chemotherapy. 4) Plasma testosterone revealed normal levels in any therapeutic programs employed in the present study. 5) From the results of Gn-RH test, the pituitary gland seemed to have normal function. 6) Plasma testosterone showed incomplete response to hCG stimulation after 1 to 35 months of radiation or chemotherapy. Therefore, it was suggested that radiation and chemotherapy for the treatment of testicular tumor may impair not only seminiferous tubules but also Leydig cell for a couple of years. (author)

  2. Endocrinology of Testicular Descent and Hormonal Therapy in Cryptorchidism

    Directory of Open Access Journals (Sweden)

    M Mollaiyan

    1998-05-01

    Full Text Available The mystery of testicular descent remains a challenge for urological research. In this article the impressive investigational output in recent years, especially the role of mullerian inhibitory substance and the genito-femoral nerve, are reviewed. It is currently suggested that hypogonadotropic hypogonadism plays a more central; role. How this interacts in the complex process of testicular descent remains to be investigated. Testicular biopsies in cryptorchidism demonstrate histologic depletion of germ cells and leydig cells in undescended testicle, as well as in the contralateral descended testis in many cases. European use LHRH and HCG for assisting scrotal positioning of "Almost" descended testes, while north American investigators use HCG, but not LHRH hormone, to reveal retractile testes.

  3. Leydig cell damage after testicular irradiation for lymphoblastic leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Shalet, S.M.; Horner, A.; Ahmed, S.R.; Morris-Jones, P.H.

    1985-01-01

    The effect of testicular irradiation on Leydig cell function has been studied in a group of boys irradiated between 1 and 5 years earlier for a testicular relapse of acute lymphoblastic leukemia. Six of the seven boys irradiated during prepubertal life had an absent testosterone response to HCG stimulation. Two of the four boys irradiated during puberty had an appropriate basal testosterone level, but the testosterone response to HCG stimulation was subnormal in three of the four. Abnormalities in gonadotropin secretion consistent with testicular damage were noted in nine of the 11 boys. Evidence of severe Leydig cell damage was present irrespective of whether the boys were studied within 1 year or between 3 and 5 years after irradiation, suggesting that recovery is unlikely. Androgen replacement therapy has been started in four boys and will be required by the majority of the remainder to undergo normal pubertal development.

  4. Colloidal cyst of the third ventricle. Case presentation Quiste coloide del tercer ventrículo. Presentación de un caso

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    Joan O Rojas Fuentes

    2009-09-01

    Full Text Available

    Colloidal cysts are congenital intracranial benign lesions of the anterior superior portion of the third ventricle. They represent between the 0,2 and 2 % of all the intracranial tumours and represent the 15 or 20 % of all the intraventricular masses. They become symptomatic during the adolescence or early adulthood and start normally with migraine or symptoms of intracranial hypertension causing obstructive hydrocephaly. We present the case of a teenager of 18 years of age with history of migraine after two years and the symptoms worsened in intensity and frequency including vomiting and bilateral paresthesia; the diagnosis was obstructive hydrocephaly with colloidal cyst of the third ventricle. An appropriate practice was adopted due to the uncertain diagnosis in order to avoid neurological damage and death. We discussed the main characteristics of the colloidal cyst, its clinical presentation and radiological characteristics and we performed.

    Los quistes coloides son lesiones intracraneales congénitas benignas, de la porción antero-superior del tercer ventrículo. Suponen del 0,2 al 2 % de todos los tumores intracraneales y representan del 15 al 20 % de todas las masas intraventriculares. Comienzan a ser sintomáticos en la adolescencia o edad adulta temprana, generalmente con manifestaciones de cefalea o síntomas de hipertensión intracraneal al provocar hidrocefalia obstructiva. Se presenta una adolescente de 18 años con historia de cefalea de 2 años de evolución, cuyos síntomas fueron empeorando en intensidad y frecuencia, acompañados de vómitos y parestesias bilaterales; se le diagnosticó hidrocefalia obstructiva con quiste coloide del tercer ventrículo. Ante la sospecha del diagnóstico se tomó una conducta adecuada, para evitar el deterioro neurológico y la muerte. Se discutieron las principales características del quiste coloide, su cuadro clínico y radiológico.

  5. [Psychosomatic aspects of treated testicular neoplasm patients].

    Science.gov (United States)

    Janssen, P L; Weissbach, L

    1978-01-01

    We examined 26 patients who were semicastrated, lymphadenectomied and cytostatic treated because of a maligne testicular tumor to find out the secondary psychic manifestation of this organic illness. Somatic caused consequences of operation were a unilateral loss of testis and a loss of ejaculation and therefore a generative impotency. We found no evidence for a primary psychic influence on the origin of tumor illness. We could subdivide the secondary psychic manifestation in two stages: 1. The psychodynamik at the time of diagnostic and operation, 2. the specific personal mechanism of conflictmanagement in the following time, the phase of rehabilitation. In the first stage we subdivided three different states during the acute crisis with regard to regression, to mobilisation of infantil drives and to defence: 1. Disavowal, 2. Helplessness, 3. Fight. We discussed the psychodynamic and the attachment of these affective states to the psychology of neurosis. In the second stage of the secondary psychic manifestation we could find different more or less durable strategies of conflictmanagement: So called normal conflictmanagement, conflictmanagement by disavowal, by different mechanism of compensation as oral symbiotic dependences, narcissistic increasing of potency, intensified productivity, forming of religious ideal and by secondary hypochondric processes. The sexual disorders which we could state in about 1/3 of the patients existed mostly in an avoid of sexual partnership because of anxiety concerning narcissistic grief and injury of selfesteem. In older patients with special liability to crisis we found also an erective impotency. All patients with sexual disorders showed also psychoneurotic and psychosocial disorders. We discussed the results with regard to forming of hypothesis in psychosomatics, to personal and interpersonal conflictmanagement and to supportive psychotherapeutic possibilities. PMID:565114

  6. Testicular Synovial Sarcoma: A Case Report

    International Nuclear Information System (INIS)

    This paper reports a case of testicular synovial sarcoma with molecular genetic analysis. A 24-year-old male presented with painless scrotal mass. Ultrasonography showed a heterogeneous mass of 66 mm × 34 mm in size involving the inguinal region. Histological examination of a surgical biopsy showed a grade III monophasic growth pattern of spindle cell proliferation. Immunohistochemical analyses indicated positive staining for pancytokeratine and epithelial membrane antigen. Cytogenetic analysis showed the presence of CYT-SSX1 mutation, and CT scan showed non-specific pleural micro-nodules with a size of 7.5 mm. The patient had an extended left orchidectomy but was lost to follow-up for 1 year. A local recurrent scrotal mass of 32 mm × 25 mm, multiple inguinal lymph nodes, and increased pleural nodules, which were confirmed by histological examination, were treated with three cycles of adriamycine and ifosfamide chemotherapy, surgical resection, and radiotherapy with complete response. After 3 months, the patient developed local recurrence and pulmonary metastases that did not respond to second-line chemotherapy based on gemcitabine and paclitaxel. The patient had dyspnea at the time of this writing and chest pain, and is under third-line chemotherapy based on Deticene after 30 months of following up. This patient died on November 16, 2012 after a resperatory failure and malignant pelural effusion. Synovial sarcoma should be considered in the differential diagnosis of soft tissue tumor and it should be aggressively treated to improve prognosis. Although our patient has shown numerous factors of bad prognosis, he has had a relatively long survival time

  7. Testicular Parameters and Morphological Characteristics of Testicular and Epididymal Spermatozoa of White Fulani Bulls in Nigeria Parámetros Testiculares y Características Morfológicas de los Espermatozoides Testicular y Epididimal de Toros Fulani Blancos en Nigeria

    Directory of Open Access Journals (Sweden)

    Matthew Olugbenga Oyeyemi

    2006-06-01

    Full Text Available Testicular parameters and morphological characteristics of testicular and epididymal spermatozoa of white Fulani bulls were study using twenty testicles. The objective was to study the normal testicular parameter and morphological changes during epididymal transit in the epididymis of white Fulani bulls. It was observed that there was reduction in the proportion of spermatozoa carrying the proximal cytoplasmic droplet (PCD along the epididymis as spermatozoa mature. There were more narrow head in the left (0.40 than the right epididymis (0.10. There was more bent normal tail (16.7 in the left epididymis than in right epididymis (13.0. The sperm cells having looped tails are higher in the left epididymis (caput, 4.90; corpus, 5.30; caudal 4.30 than the right epididymis (caput, 4.70; corpus, 3.20; caudal 5.10 despite the fact that the caudal epididymis in the right epididymis has a higher mean value. In this study the left testicle had more of the morphologically defective spermatozoa (12.96% than the right testicles (12.42%. The epididymal and testicular parameters were positively correlated (weight of epididymis, weight of estis and epididymis, length of epididymis, circumference of the testes and epididymis, (pSe estudiaron parámetros testiculares y características morfológicas de los espermatozoides testiculares y epididimarios en 20 testículos de toros Fulani blancos. El objetivo fue determinar parámetros testiculares normales y los cambios morfológicos de los espermatozoides durante su trayecto en el epidídimo. Se observó que hubo disminución de espermatozoides llevando droplet citoplasmático proximal (PCD en el epidídimo, durante la maduración espermática. Se presentaron más cabezas estrechas en el epidídimo izquierdo (0,40 que en el derecho (0,10. Hubo más espermatozoides con cola normal (16.7 en el epidídimo del lado izquierdo que en el lado derecho (13.0. Las células espermáticas tenían colas en loop en mayor cantidad en el epidídimo izquierdo (cabeza, 4.90; cuerpo, 5.30; cola 4.30 que en el lado derecho (cabeza, 4.70; cuerpo, 3.20; cola 5.10. Sin embargo, en la zona caudal del epidídimo derecho el valor promedio fue más alto. En este estudio, en el testículo izquierdo los espermatozoides presentaron más defectos morfológicos (12.96 que en el derecho (12.42. Entre los parámetros epididimarios y testiculares hubo correlación positiva (peso del epidídimo, peso de los testículos y epidídimos, longitud del epidídimo y circunferencias de los testículos y epidídimos p<0.05

  8. Simultaneous ipsilateral testicular seminoma with pelvic ectopy and hematovesicula seminalis

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    Hadži-Đokić Jovan

    2012-01-01

    Full Text Available We present a rare case of 24 years old male who was diagnosed with simultaneous testicular tumor with pelvic ectopy and ipsilateral hematovesicula seminalis. Hemospermia was the only presented symptom. Patient underwent surgery and removal of the testicular tumor and right vesiculectomy were performed.Histopathological analysis revealed seminoma of the right testis and dilated right vesicula seminalis filled with hemorrhagic fluid and sings of chronic inflammation. Postoperatively irradiation of the abdomen was performed using standard protocol. Ten years after surgery there was no signs of decease recurrence.

  9. Simultaneous ipsilateral testicular seminoma with pelvic ectopy and hematovesicula seminalis.

    Science.gov (United States)

    Hadzi-Djokić, Jovan; Andrejević, Vladan; Djurasić, Ljubomir; Aćimović, Miodrag; Petrović, Milan; Pejcić, Tomislav; Dzamić, Zoran

    2012-01-01

    We present a rare case of 24 years old male who was diagnosed with simultaneous testicular tumor with pelvic ectopy and ipsilateral hematovesicula seminalis. Hemospermia was the only presented symptom. Patient underwent surgery and removal of the testicular tumor and right vesiculectomy were performed. Histopathological analysis revealed seminoma of the right testis and dilated right vesicula seminalis filled with hemorrhagic fluid and sings of chronic inflammation. Postoperatively irradiation of the abdomen was performed using standard protocol. Ten years after surgery there was no signs of decease recurrence. PMID:23654019

  10. Radionuclide diagnostics of testicular blood flow changes in varicocele

    International Nuclear Information System (INIS)

    Gamma camera scintigraphy is performed in 82 patients presenting varicocele associated with fertility and spermatogenesis impairment. A new method of quantitative and semi-quantitative assessment of testicular blood and vascularity is used to reveal changes in testicular blood flow due to varicocele. The obtained radionuclide indices are typical of the disease, and their numerical values illustrate the changes in the blood vessels and capillary tissue vascularity. The varicocele curve proper has a very characteristic pattern, and enables different diagnosis with focal epididymitis of the head of epididyms. The radionuclide indices and their values are also used to assess the severity of the disease. 5 refs., 4 figs. (orig.)

  11. Sexual dysfunctions in men treated for testicular cancer

    DEFF Research Database (Denmark)

    Rosendal, Susanne; Kristensen, Ellids; Giraldi, Annamaria G E

    2008-01-01

    Patients treated for testicular cancer have increased risk of ejaculatory, orgasmic and erectile dysfunction compared with healthy men. The underlying relations are unclear. This review describes sexual dysfunctions that are associated with various treatment modalities. One meta-analysis and 11...... original works were examined. About one third of the patients experience one or more sexual problems in relation to the treatment. Only retroperitoneal surgery can cause a specific sexual dysfunction, namely loss of ejaculation ability or ejaculatory functioning. Psychosexual causes are important for...... understanding sexual dysfunctions in patients with testicular cancer....

  12. Ultrassonografia testicular em caprinos jovens da raça Alpina

    OpenAIRE

    L.R.B. Carazo; J.D. Guimarães; T.P. Machado; T.P.L.C. Machado; F.A.S.A.M. Oliveira; Pereira, D.B.

    2014-01-01

    Objetivou-se com este trabalho observar as mudanças do parênquima testicular de acordo com o fotoperíodo e com a faixa etária dos animais por meio da ecotextura testicular e a viabilidade do uso do ultrassom na avaliação testicular. Foram utilizados 4 animais desde o 6° até o 13° mês de idade. Os exames ecográficos foram realizados a cada 15 dias para avaliar a ecotextura testicular. O parênquima testicular mostrou-se moderadamente ecogênico e homogêneo. Foi observado comportamento semelhante...

  13. Ultrasonographic diagnosis of torsion of testicular appendages; Diagnostico por ecografia de la torsion de los apendices testiculares

    Energy Technology Data Exchange (ETDEWEB)

    Esparza, J.; Gonzalez, A.; Cordero, J. L. [Hospital Virgen del Camino. Pamplona (Spain)

    2000-07-01

    To determine the efficacy of ultrasound in boys presenting torsion of a testicular appendage. A series of 30 boys with acute scrotal pain due to torsion of a testicular appendage was studied. Nine patients underwent surgery. The clinical findings and course in the remaining 21 suggested the presence of this abnormality. All of them underwent conventional and color Doppler ultrasound using a 7.5 MHz transducer. In 15 boys, ultrasound images depicted the affected appendage as a mass between the epididymal head and the testicle. In 13 cases, only signs of a inflammatory reaction, with enlargement of the epididymal head and tunicas presenting hyperflow and hydrocele, mimicking acute epididymities. In two cases, the images were normal. There is no definitive, distinguishing ultrasound image corresponding to testicular appendage torsion. Therefore, this diagnostic technique should be accompanied by clinical assessment. (Author) 14 refs.

  14. Platelet-derived growth factor type BB and collagen matrix for soft tissue reconstruction after muco-epidermoid carcinoma removal: A possible therapeutic option

    Directory of Open Access Journals (Sweden)

    Marco Cicciù

    2015-01-01

    Full Text Available Muco-epidermoid carcinoma (MEC is a rare malignant tumor occurring in major and minor salivary glands. The described case shows a patient undergoing tumor resection without neck dissection. A quick diagnosis performed through clinical investigation and incisional biopsy revealed the nature of the tumor. A porcine collagen matrix was applied after the surgery in order to improve soft tissue healing. The matrix was saturated with platelet-derived growth factor type BB in order to favorite healing process and then fixed on the palate with a dental support device. Follow-up visit performed at first, second, and third weeks highlighted a quick healing of oral mucosa. Here reported is a case of a 34-year-old man who developed a muco-epidermoid oral carcinoma localized in the left upper jaw palatal side. The clinical, radiographic, and histopathologic findings, plus differential diagnoses of the case and reconstructive treatment options are also presented.

  15. Manejo laparoscópico de quiste gigante de ovario: reporte de caso A case report of laparoscopic management of a giant cystic ovarian mass

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    Federico Zapata-Pérez

    2009-03-01

    Full Text Available Objetivo: revisar las consideraciones técnicas, indicaciones, riesgos y beneficios de este tipo de abordaje en masas pélvicas gigantes. Se presenta un caso en el que se realizó el abordaje laparoscópico de una masa quística ovárica de gran tamaño y su extracción a través de colpotomía posterior. La cirugía laparoscópica de los quistes gigantes de ovario surge como una alternativa a considerar en el manejo de estas pacientes.Objective: reviewing technical considerations, indications, risks and benefits of a laparoscopic approach to giant ovarian cysts. A case is presented where a giant ovarian cyst was extracted by posterior colpotomy. Laparoscopic surgery on giant pelvic mass represents an alternative for managing such patients.

  16. Presentación de un caso de quiste dermoide con ubicación poco frecuente / Presentation of a dermoid cyst case with an unusual location

    Scientific Electronic Library Online (English)

    A., Ostrosky; R., Luberti; E., Mareso; J., Klurfan Federico.

    2005-02-01

    Full Text Available El quiste dermoide es una patología benigna de origen embrionario y su localización en el piso de la boca es poco frecuente. No presenta predilección por sexo y aparece, especialmente, entre la segunda y la tercera década de vida. Para su diagnóstico son útiles las tomografías computadas y las reson [...] ancias nucleares magnéticas. El tratamiento es quirúrgico. Tanto las recidivas como la transformación maligna son excepcionales. Abstract in english The Dermoid Cyst is a benign pathology of embrionary origin and its localization in the floor of the mouth is not very frequent. With no preference for sex, it appears especially between the second and third decades of life. Computed scans and magnetic nuclear reso-nances are useful for its diagnosi [...] s. The treatment is surgical and recurrences, as well as malignant transformation, are exceptional.

  17. Presentación de un caso de quiste dermoide con ubicación poco frecuente Presentation of a dermoid cyst case with an unusual location

    Directory of Open Access Journals (Sweden)

    A. Ostrosky

    2005-02-01

    Full Text Available El quiste dermoide es una patología benigna de origen embrionario y su localización en el piso de la boca es poco frecuente. No presenta predilección por sexo y aparece, especialmente, entre la segunda y la tercera década de vida. Para su diagnóstico son útiles las tomografías computadas y las resonancias nucleares magnéticas. El tratamiento es quirúrgico. Tanto las recidivas como la transformación maligna son excepcionales.The Dermoid Cyst is a benign pathology of embrionary origin and its localization in the floor of the mouth is not very frequent. With no preference for sex, it appears especially between the second and third decades of life. Computed scans and magnetic nuclear reso-nances are useful for its diagnosis. The treatment is surgical and recurrences, as well as malignant transformation, are exceptional.

  18. Quiste de retención prostético: una causa rara de retención aguda de orina Prostatic cyst causing urinary obstruction: Report of one case

    Directory of Open Access Journals (Sweden)

    PABLO PRIEGO J

    2008-06-01

    Full Text Available Las lesiones quísticas localizadas en la línea media de la glándula prostética presentan una incidencia difícil de estimar, debido a que la mayoría son asintomáticas y suelen ser un hallazgo casual durante el estudio de otra patología urológica¹. Presentamos el caso de un varón de 85 años que en el transcurso de un episodio de retención aguda de orina es diagnosticado de un quiste de retención prostético, y realizamos una revisión de la literaturaThe incidence of medial prostatic cysts is unknown, since most of them are asymptomatic, and usually appear as an incidental finding during the study of other urological disease. We report an 85 years oíd man with a urinary obstruction. Rectal palpation disclosed a mass that was adjacent to the prostate. Magnetic resonance showed a cystic lesión of the right seminal vesicle. The cyst was drained, obtaining 250 mi of fluid and urinary obstruction subsided. After three months of follow up, the patient remains asymptomatic

  19. Distensión abdominal y edemas por quiste del cordón espermático Abdomina distention and edema due to spermatic cord cyst

    OpenAIRE

    Guillermo A. Keller; Cecilia Sessa

    2006-01-01

    La distensión abdominal es un síntoma común, siendo en general la presentación inicial de enfermedades sistémicas o desórdenes gastrointestinales. Otras causas son infrecuentes. Los quistes del cordón espermático son poco frecuentes, pero aún más su ubicación intraabdominal, su tamaño habitual es insuficiente para producir distensión. El paciente presentado en este caso es un varón con criptorquidia bilateral admitido por distensión abdominal, interpretada inicialmente como síndrome ascítico ...

  20. Investigación experimental de la equinococosis canina a partir de quiste hidatídico de origen porcino en México

    OpenAIRE

    Zuñiga-A Ismael; Jaramillo-A Carlos J; Martínez-M José J; Cárdenas-L Jorge

    1999-01-01

    OBJETIVO: Para evaluar la infección y obtener el estado adulto del cestodos, se buscó reproducir la equinococosis en perros a partir de quiste hidatídico de origen porcino. MÉTODOS: Se formaron 2 grupos, uno de 5 y otro de 3 perros, a cada animal del grupo experimental se le dió 2 g de membrana germinativa de quíste hidatídico fértil por vía oral, el segundo grupo fue testigo. Ambos grupos fueron evaluados clínica, serológica y parasitológicamente, en el grupo experimental se sacrificó un ani...

  1. Torsión testicular in útero: reporte de un caso Intra-uterine testicular torsion: a case report

    OpenAIRE

    Alejandro Álvarez J; Carmen Sandoval C; Mario Zapata M

    2003-01-01

    La torsión testicular puede producirse en la vida fetal o en el recién nacido siendo una patología poco frecuente. Objetivo: Dada la baja frecuencia de la torsión testicular in útero y la escasez de publicaciones en nuestro medio, consideramos importante mostrar nuestra experiencia. Caso clínico:recién nacido de término, de 41 semanas, adecuado para la edad gestacional; al examen físico post parto se encuentra un testículo izquierdo de consistencia pétrea e hidrocele derecho. Se le realizó ec...

  2. Leydig-cell function in children after direct testicular irradiation for acute lymphoblastic leukemia

    International Nuclear Information System (INIS)

    To assess the effect of testicular irradiation on testicular endocrine function, we studied 12 boys with acute lymphoblastic leukemia who had been treated with direct testicular irradiation 10 months to 8 1/2 years earlier. Insufficient Leydig-cell function, manifested by a low response of plasma testosterone to chorionic gonadotropin or an increased basal level of plasma luteinizing hormone (or both), was observed in 10 patients, 7 of whom were pubertal. Two of these patients had a compensated testicular endocrine insufficiency with only high plasma concentrations of luteinizing hormone. Testosterone secretion was severely impaired in three pubertal boys studied more than four years after testicular irradiation. A diminished testicular volume indicating tubular atrophy was found in all pubertal patients, including three who had not received cyclophosphamide or cytarabine. These data indicate that testosterone insufficiency is a frequent complication of testicular irradiation, although some patients continue to have Leydig-cell activity for several years after therapy

  3. Leydig-cell function in children after direct testicular irradiation for acute lymphoblastic leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Brauner, R.; Czernichow, P.; Cramer, P.; Schaison, G.; Rappaport, R.

    1983-07-07

    To assess the effect of testicular irradiation on testicular endocrine function, we studied 12 boys with acute lymphoblastic leukemia who had been treated with direct testicular irradiation 10 months to 8 1/2 years earlier. Insufficient Leydig-cell function, manifested by a low response of plasma testosterone to chorionic gonadotropin or an increased basal level of plasma luteinizing hormone (or both), was observed in 10 patients, 7 of whom were pubertal. Two of these patients had a compensated testicular endocrine insufficiency with only high plasma concentrations of luteinizing hormone. Testosterone secretion was severely impaired in three pubertal boys studied more than four years after testicular irradiation. A diminished testicular volume indicating tubular atrophy was found in all pubertal patients, including three who had not received cyclophosphamide or cytarabine. These data indicate that testosterone insufficiency is a frequent complication of testicular irradiation, although some patients continue to have Leydig-cell activity for several years after therapy.

  4. Linfoma testicular primario: Aportación de un nuevo caso y revisión de la literatura / Primary testicular lymphoma: Contribution of one case and literature review

    Scientific Electronic Library Online (English)

    I., Gómez García; R., Rodríguez Patrón; E., Sanz Mayayo; J.M., Rodríguez Luna; A., Palmeiro Uriach; S., Conde Someso; F.J., Burgos Revilla; D., García Ortells; A., Escudero Barrilero.

    2004-02-01

    Full Text Available El linfoma testicular primario es un tumor testicular infrecuente, suponiendo no más del 9% de los tumores testiculares en las series con mayor incidencia; a su vez el linfoma testicular como tumor hematopoyético es infrecuente, con una incidencia del 1% de los linfomas, pero debido a su histopatolo [...] gía en la mayoría de los casos de alta malignidad, les hace ser de los tumores testiculares más agresivos. La edad de aparición es por encima de los 60 años, convirtiéndose en el tumor más frecuente para este grupo de edad. La falta de series amplias, hace que no exista un protocolo establecido para el tratamiento de esta patología. Presentamos un nuevo caso, realizando revisión de la bibliografía presentando las tendencias terapéuticas actuales para este tipo de patología. Abstract in english Primary testicular lymphoma is an uncommon testicular tumour that accounts for no more than 9% of all testicular tumours in those series with higher incidence; testicular lymphoma as haematopoietic tumours are also rare accounting for just 1% of all lymphomas; but due to their highly malignant histo [...] pathology they may become highly aggressive tumours. Patient age at presentation is over 60 years old which makes it the most frequent tumour for this age group. There is no standard protocol to treat this malignancy due to lack of extensive series. We contribute one case and make a literature review discussing the current therapeutic trends for this disease.

  5. Carcinoma Epidermoide Primario de la Mama: Una Infrecuente Entidad Clínico-Patológica Primary Squamous Cell Carcinoma of the Breast: A Rare Clinicopathological Entity

    OpenAIRE

    Oscar Tapia E

    2011-01-01

    El carcinoma epidermoide (CE) puro primario de la mama es una rara entidad clínico-patológica, que representa menos del 0,1% de todos los carcinomas de mama, conformada en su totalidad por células escamosas malignas que no presentan relación anatómica con la piel adyacente de la mama. Su etiopatogenia, pronóstico y tratamiento son motivo de controversias. Presentamos 1 caso de CE puros primario de la mama diagnosticado en la Unidad de Anatomía Patológica del Hospital Hernán Henríquez Aravena ...

  6. Quistes sinoviales de columna lumbar: una causa de compresión radicular Synovial Cysts of the Lumbar Spine: a Cause of Radicular Compression

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    Francisco Mery

    2000-01-01

    Full Text Available Los quistes sinoviales (QS de columna lumbar son lesiones infrecuentes pero deben considerarse frente a casos de compresión radicular. Existe controversia acerca de su patogenia y se describen múltiples opciones terapéuticas. Se presenta una serie clínica retrospectiva de siete pacientes tratados en un período de ocho años. En general fueron pacientes mayores de 60 años, con un cuadro de dolor radicular unilateral, que se presentó 3 meses antes del diagnóstico. Sólo dos pacientes tuvieron déficit de la raíz correspondiente. Todos los QS se localizaron en el nivel L4-L5, realizándose hemilaminectomía y resección total del quiste. Seis casos tuvieron desaparición completa del dolor. Un paciente presentó sólo alivio moderado, constatándose espondilolistesis, por lo que fue sometido posteriormente a una fusión vertebral, mejorando su sintomatología. La cirugía es un tratamiento seguro y eficaz para la resolución de esta patología. La literatura acerca de esta importante patología fue revisadaSynovial cysts of the lumbar spine are uncommon lesions, but they should be considered in cases with radicular compression. Their pathogeny is controversial, and multiple therapeutic options have been describes. We are reporting on a retrospective clinical series of seven patients treated in eight years. In general, the patients were over 60, with unilateral radicular pain starting three months before diagnosis. Only two patients had root deficit. All lesions affected L4-L5 level. Hemilaminectomy and resection of the cyst were performed. Six patients had complete resolution of pain. One patient presented moderate pain relief, and subsequently underwent a vertebral fusion because of spondylolisthesis, with a successful outcome. The surgery is a safe and effective treatment for this lesion. The literatura concerning this important pathology is also reviewed

  7. Detecção do rearranjo da proteína BCL2/JH em carcinomas epidermoides de boca e faringe / Detection of protein BCL2/JH rearrangement in epidermoid carcinomas of mouth and pharynx

    Scientific Electronic Library Online (English)

    Jair, Montovani; Magaly M, Sales; Maria Inês M C, Pardini.

    2010-09-01

    Full Text Available INTRODUÇÃO: A proteína BCL2 encontrada na membrana mitocondrial interna, regula a apoptose inibindo a morte celular programada. A translocação (14;18), detectada em 70 a 85% dos linfomas foliculares, leva a superexpressão da proteína BCL2, pela justaposição do gene BCL2 ao segmento JH do gene da cad [...] eia pesada da imunoglobulina. Porém, os achados da expressão da BCL2 em carcinoma de cabeça e pescoço são contraditórios. OBJETIVO: Investigar a presença da translocação (14;18) do gene BCL2 em carcinomas de cabeça e pescoço. MÉTODO: Foram examinadas 16 amostras de DNA, sendo 13 de carcinomas de células escamosas (CCE) e 3 de epidermoide (CE), por meio da reação em cadeia da polimerase (PCR). RESULTADOS: O rearranjo BCL2/JH foi encontrado em 2 (15%) dos 13 casos de CCE e em nenhum dos 3 casos de CE. A média de frequência de moléculas com rearranjo foi de 46,44 x 107. Não foi observada associação entre a presença de rearranjo e a exposição ao tabaco e álcool (p=0,6545). CONCLUSÃO: Diferente dos resultados encontrados em linfomas foliculares a presença da translocação (14;18) em carcinomas de cabeça e pescoço não é comum e, quando ocorre, pode ser uma mutação ocasional não associada a exposição ao tabaco e álcool. Abstract in english INTRODUCTION: The BCL2 protein found in the internal mothocondrial membrana regulates the apoptosis preventing the programmed cell death. The translocation (14:18), detected in 70 to 85% of the follicular lymphoma, lead the super expression of BCL2 protein, by juxtaposition of BCL2 gene to the JH se [...] gment of the immunoglobulins' heavy chain gene. However, the found of the BCL2 expression in head and neck carcinoma are contradictious. OBJECTIVE: To investigate the presence of the translocation (14:18) of the BCL2 gene in head and neck carcinoma. METHOD: Sixteen DNA samplers were examinated being 13 of squamous cells carcinoma (SCC) and 3 of epidermoid (CE), y means of chain reaction of the polymerase (PCR). RESULTS: The BCL2/JH rearrangement in 2 (15%) of the CCE 13 cases and in none of the 3 cases of CE. The average of the frequency of molecules with rearrangement was 46,44x107. Was not observed association between the rearrangement presence and the exhibition to tobacco and alcohol (p=0, 6545). CONCLUSION: Different from the results found in follicular lymphoma, the presence of the translocation (14; 18) in head and neck carcinomas is not common and, when it occurs, it can be an occasional mutation not associated to exhibition to the tobacco and alcohol.

  8. Cerebello-pontine angle epidermoid cyst, with special reference to metrizamide CT cisternographic findings suggesting communication of the cyst with the subarachnoid space

    International Nuclear Information System (INIS)

    A case of left C-P angle epidermoid cyst with possible communication with the subarachnoid space based on the findings of metrizamide CT cisternography, RI cisternography and surgery, is described. A 46-year-old female was admitted due to left hemifacial spasm, ringing and loss of auditory of the left ear, and gait disturbance of over ten years' duration. CT-scan revealed a large low density area in the posterior fossa (+4 to +5 Hounsfield units) with partial capsular enhancement. On metrizamide CT cisternography, a bizarre-shaped area of high density appeared within the confines of the low density area at 1 hour after intrathecal injection of metrizamide and persisted for hours. This suggested metrizamide penetration from the subarachnoid space into the cyst through the capsule. RI cisternography revealed definitely increased RI uptake into the cyst in the same sequence as the metrizamide CT cisternography. Following left suboccipital craniectomy, a cystic pearly tumor was noted beneath the left cerebellar hemisphere. Its thin capsule was in contact with the distended cisterna magna. Following aspiration of the cyst fluid, the distended cisterna magna collapsed synchronously. These findings, including those of metrizamide CT and RI cisternography, clearly suggested the existence of communication of fluid between the epidermoid cyst and subarachnoid space. Histological examination confirmed epidermoid cyst. (author)

  9. Testicular damage and farming environments - An integrative ecotoxicological link.

    Science.gov (United States)

    Parelho, Carolina; Bernardo, Filipe; Camarinho, Ricardo; Rodrigues, Armindo Santos; Garcia, Patrícia

    2016-07-01

    The exposure to agrochemicals during farming activities affects the function of the reproductive system, as revealed by the increasing worldwide evidence of male infertility amongst farmers. The main objective of this study was to untangle the link between agricultural practices and male reproductive impairment due to chronic exposure to xenobiotics (such as agrochemicals) in conventional and organic farming environments. For this purpose, male wild mice (Mus musculus) populations from sites representing two distinct farming practices (conventional and organic farming systems) were used as bioindicators for observable effects of testicular damage, namely on a set of histological and cellular parameters: (i) relative volumetric density of different spermatogenic cells and interstitial space; (ii) damage in the seminiferous tubules and (iii) apoptotic cells in the germinal epithelium. Results showed that mice from the conventional farming site bioaccumulated higher Pb hepatic loads, while mice from the organic farming site tend to bioaccumulate higher Cd hepatic loads. In general, for the analyzed testicular damage related parameters, mice from the organic farming site showed a similar performance than mice from the reference site. Mice from the conventional farming site stood out not only by underperforming in most studied parameters, while displaying an association between Pb hepatic loads and the observed testicular structural and functional disruption, but also by the increased stress index (Integrated Biomarker Response value). This study highlights the potential damaging effects of conventional farming practices on testicular structure and function, under natural conditions, raising concern about ensuing fertility risks for farmers. PMID:27108371

  10. Spermiophages on testicular fine needle aspiration cytology: A rare finding.

    Science.gov (United States)

    Jashnani, Kusum; Desai, Heena; Shetty, Jyothi

    2016-03-01

    Macrophages usually reside in the testicular interstitial tissues and are normally not found within the seminiferous tubules. However, in certain cases of male infertility, the macrophages are activated and can then be found within the tubules where they can ingest spermatozoa and are labeled as "spermiophages." FNAC was performed in a 36 year male with history of primary infertility. On microscopy, smears made from right testis were indicative of hypospermatogenesis. On the contrary, smears made from the left testis were very cellular showing Sertoli cells and the entire spectrum of normal spermatogenesis. Also seen were many isolated spermiophages. The cytological impression given for the left testis was normal spermatogenesis with numerous spermiophages. Thus the patient fell in the category of obstructive azoospermia (OA). According to currently adopted hypothesis, macrophages carry ingested sperm heads with some antigenic components to the basal capillaries which may result in the formation of autoantibodies against the spermatozoa. This situation may further diminish the chances of fertility in men. The origin of these spermiophage cells is unknown. Although commonly reported in semen and epididymal biopsies, they have not been reported to occur on testicular fine needle aspiration cytology (FNAC). In our case, no sperms were found on semen examination which were easily picked up on testicular FNAC indicating usefulness of the latter in the diagnosis of cases of male infertility and eliminating the need for a testicular biopsy. Diagn. Cytopathol. 2016;44:232-234. © 2015 Wiley Periodicals, Inc. PMID:26875595

  11. Combined malignant testicular tumor and splenogonadal fusion. A case story

    DEFF Research Database (Denmark)

    Thomsen, B M; Wierød, F S; Rasmussen, K C

    1997-01-01

    Splenogonadal fusion may be misinterpretated as a primary malignant testicular tumor or as an adenomatoid tumor. Knowledge of this entity is important in order to preserve the testis at surgery. A rare case of simultaneous occurrence of splenogonadal fusion and mixed malignant tumor of the testis...

  12. The effect of the melatonin on cryopreserved mouse testicular cells

    Directory of Open Access Journals (Sweden)

    Ghasem Saki

    2016-01-01

    Full Text Available Background: After improvements in various cancer treatments, life expectancy has been raised, but success in treatment causes loss of fertility in many of the survived young men. Cryopreservation of immature testicular tissues or cells introduced as the only way to preserve fertility. However, freezing has some harmful effects. Melatonin, a pineal gland hormone, has receptors in reproductive systems of different species. It is assumed that melatonin has free radical scavenger properties. Objective: The aim of this study was to evaluate the effects of melatonin on the cryopreserved testicular cells in mouse. Materials and Methods: Cells from 7- 10 days old NMRI mice testes were isolated using two step enzymatic digestion. The testicular cells were divided into two groups randomly and cryopreserved in two different freezing media with and without the addition of 100 μm melatonin. Finally, apoptosis of the cells was assayed by flow cytometry. Also, lactate dehydrogenase activity test was performed to assess the cytotoxicity. Results: The results of lactate dehydrogenase showed the nearly cytotoxic effect of melatonin. The results of flow cytometry showed increase in apoptosis in the cryopreserved cells in the media containing melatonin compared to the control group. Conclusion: The present study shows that melatonin has an apoptotic effect on cryopreserved mouse testicular cells.

  13. Unusually Located Stroke After Chemotherapy in Testicular Germ Cell Tumors

    OpenAIRE

    Martinez, Braulio Alexander; Correa, Edgar Patricio

    2015-01-01

    Testicular cancer is a type of malignancy that affects young adults and has high rates of cure; however, as any malignancy, it is associated with an increased risk of ischemic or hemorrhagic cerebrovascular disease, given the systemic tumor effects or side effects of chemotherapy, which in turn increases morbidity, functional impairment, and additional risk of early death.

  14. Secondary Varicocele Caused by Pancreatic Pseudocyst Obstructing Testicular Venous Drainage

    Directory of Open Access Journals (Sweden)

    Yashant Aswani

    2013-11-01

    Full Text Available A pseudocyst is a fluid/debris collection that occurs as a complication of pancreatitis. It can be symptomatic and causecompression of the surrounding structures. Our case report highlights a 29-year-old male who presented with secondaryvaricocele on left side caused by a huge pseudocyst seen to compress the left renal and testicular veins.

  15. Genetics Home Reference: 46,XX testicular disorder of sex development

    Science.gov (United States)

    ... ambiguous genitalia than are people with the SRY -positive form. Learn more about the gene and chromosomes associated with 46,XX testicular disorder of sex development SRY X chromosome Y chromosome Related Information What is a gene? How can gene mutations ...

  16. The effect of the melatonin on cryopreserved mouse testicular cells

    Science.gov (United States)

    Saki, Ghasem; Mirhoseini, Mehri; Hemadi, Masoud; Khodadadi, Ali; Beygom Talebpour Amiri, Fereshteh

    2016-01-01

    Background: After improvements in various cancer treatments, life expectancy has been raised, but success in treatment causes loss of fertility in many of the survived young men. Cryopreservation of immature testicular tissues or cells introduced as the only way to preserve fertility. However, freezing has some harmful effects. Melatonin, a pineal gland hormone, has receptors in reproductive systems of different species. It is assumed that melatonin has free radical scavenger properties. Objective: The aim of this study was to evaluate the effects of melatonin on the cryopreserved testicular cells in mouse. Materials and Methods: Cells from 7- 10 days old NMRI mice testes were isolated using two step enzymatic digestion. The testicular cells were divided into two groups randomly and cryopreserved in two different freezing media with and without the addition of 100 µm melatonin. Finally, apoptosis of the cells was assayed by flow cytometry. Also, lactate dehydrogenase activity test was performed to assess the cytotoxicity. Results: The results of lactate dehydrogenase showed the nearly cytotoxic effect of melatonin. The results of flow cytometry showed increase in apoptosis in the cryopreserved cells in the media containing melatonin compared to the control group. Conclusion: The present study shows that melatonin has an apoptotic effect on cryopreserved mouse testicular cells.

  17. Testicular germ cell tumours and parental occupational exposure to pesticides

    DEFF Research Database (Denmark)

    Le Cornet, Charlotte; Fervers, Béatrice; Oksbjerg Dalton, Susanne; Feychting, Maria; Pukkala, Eero; Tynes, Tore; Hansen, Johnni; Nordby, Karl-Christian; Béranger, Rémi; Kauppinen, Timo; Uuksulainen, Sanni; Wiebert, Pernilla; Woldbæk, Torill; Skakkebæk, Niels E; Olsson, Ann; Schüz, Joachim

    2015-01-01

    OBJECTIVES: A potential impact of exposure to endocrine disruptors, including pesticides, during intrauterine life, has been hypothesised in testicular germ cell tumour (TGCT) aetiology, but exposure assessment is challenging. This large-scale registry-based case-control study aimed to investigate...

  18. Testicular torsion in a patient with Cohen syndrome.

    Science.gov (United States)

    Y?lmaz, Ömer; Ye?ildal, Cumhur; Malkoç, Ercan; Soydan, Hasan

    2015-03-01

    Cohen syndrome is an extremely rare autosomal recessive disorder. A 12-year-old boy with Cohen syndrome applied to a primary health care center because of severe pain in the left groin and was diagnosed with epididymo-orchitis. Despite the administered the antibiotic treatment, pain increased. Therefore, the family brought the patient to the emergency department 16 h after the first diagnosis. The patient had mild mental retardation, myopia, and craniofacial dysmorphism, which are components of Cohen syndrome. There was no blood flow on the left testicle at color Doppler ultrasonography. Further, scrotal exploration was performed because of a high risk of torsion. The left testicle was torsioned, and the color was dark blue. Revascularization could not be achieved by detorsion; left orchiectomy and right testicular fixation were then conducted. In conclusion, to the best of our knowledge, this is the first reported case of testicular torsion in Cohen syndrome. If a patient with this syndrome has acute groin pain, testicular torsion should be immediately ruled out with Doppler ultrasonography. These patients may not clearly and correctly express themselves because of mild mental retardation. Moreover, detailed genitourinary, particularly testicular examination may clarify the omitted pathologies and make them well known in future in this syndrome. PMID:26328200

  19. Tumores dermóides e epidermóides intra-espinhas Intraspinal epidermoid and dermoid tumours

    Directory of Open Access Journals (Sweden)

    Oscar Fontenelle Filho

    1971-03-01

    Full Text Available São relatados dois casos de tumores epidermóides e um de tumor dermóide, todos intrarraquianos. Este último era de localização epidural ao nível da coluna torácica (caso 3; os dois tumores epidermóides situavam-se na coluna tóraco-lombar (caso 1 e lombar (caso 2, respectivamente, sendo o primeiro intramedular e o segundo intradural. Em dois casos (casos 2 e 3 os tumores associavam-se a fístula dérmica congênita. Um paciente (caso 3 foi operado aos dois meses de idade; a descoberta do tumor deveu-se à realização da raquimanometria que revelou bloqueio, apesar do paciente não apresentar qualquer sinal neurológico de compressão medular. Os autores são de opinião que, em presença de fístula dérmica congênita ao nível da coluna vertebral, principalmente quando localizada acima do segmento lombosacro, deve-se sempre suspeitar da possibilidade do tumor epidermóide ou dermóide intrarraquiano, mesmo na ausência de sinais neurológicos. A combinação de sintomas neurológicos de longa duração, a evidência radiológica de erosão e alargamento do canal raquiano e a história de fístula dérmica congênita proporcionaram o diagnóstico pré-operatório correto no caso 2.Two cases of epidermoids and one case of dermoid intraspinal tumours are reported. The last case was located at thoracic level (T7 (case 3 and was epidural in localization. The two epidermoids tumours were located at the thoracic-lumbar (case 1 and lumbar (case 2 level, respectively; the first was intramedullary and the second subdural in localization. In two (cases 2 and 3 there was associated communicating pilonidal sinuses. One of the patients (case 3 was operated within the second month of age. The early discovery of the tumour in this patient was made through a lumbar raquimanometry that disclosed a complete subarachnoid block. In spite of this the patient did not presented any neurological symptoms. The authors are of opinion that in presence of a dermal fistula higher to lumbo-sacral spinal segment one must have in mind the possibility of intraspinal epidermoid or dermoid tumour, even in absence of neurological symptoms. The combination of long term clinical symptoms, radiographic evidence of pressure erosion, enlargement of the spinal canal and pilonidal sinus led to the correct preoperative diagnosis in case 2.

  20. Taurine increases testicular function in aged rats by inhibiting oxidative stress and apoptosis.

    Science.gov (United States)

    Yang, Jiancheng; Zong, Xiaomeng; Wu, Gaofeng; Lin, Shumei; Feng, Ying; Hu, Jianmin

    2015-08-01

    In males, the decline of androgen synthesis, spermatogenesis and sexual function are the main phenotypes of aging, which may be attributed to testicular dysfunction. Taurine can act as an antioxidant, a testosterone secretion stimulator, a sperm membrane stabilizer and motility factor, and an anti-apoptotic agent. Recent observational studies suggested that taurine may play an important role in spermatogenesis, but to date whether taurine has anti-aging effects on testes remains unknown. We found that in aged rats testicular SDH and G6PDH activities, marker enzymes of testes, serum testosterone, testicular 3?-HSD and 17?-HSD mRNA expression levels were significantly increased by taurine treatment. Taurine administration also markedly raised the sperm count, viability and motility, decreased the sperm abnormality. Our data suggested that taurine can postpone testicular function deterioration in aged rats. Importantly, we observed obvious elevation of testicular antioxidant enzymes (SOD, GSH, GSH-Px) activities, and remarkable reduction of ROS and MDA by taurine administration, indicating taurine can decrease testicular oxidative stress and lipid peroxidation in aged rats. Finally, we found taurine effectively reduced testicular DNA fragmentation, increased testicular Bcl-2 protein expression, and decreased cytochrome c, Bax, Fas, FasL and caspase-3 expression, suggesting taurine can prohibit aged testicular apoptosis by mitochondrial dependent and independent signal pathway. In summary, our results indicated that taurine can suppress testicular function deterioration by increasing antioxidant ability and inhibiting apoptosis. PMID:25957528

  1. Testicular torsion and weather conditions: analysis of 21,289 cases in Brazil

    Directory of Open Access Journals (Sweden)

    Fernando Korkes

    2012-04-01

    Full Text Available PURPOSE: The hypothesis of association between testicular torsion and hyperactive cremasteric reflex, worsened by cold weather, has not been proved. Thirteen studies in the literature evaluated this issue, with inconclusive results. The aim of the present study was to evaluate the seasonality of testicular torsion in a large subset of patients surgically treated in Brazil, and additionally to estimate the incidence of testicular torsion. MATERIALS AND METHODS: Brazilian Public Health System Database was assessed from 1992-2010 to evaluate hospital admissions associated with treatment of testicular torsion. Average monthly temperature between 1992-2010 was calculated for each region. RESULTS: We identified 21,289 hospital admissions for treatment of testicular torsion. There was a higher number of testicular torsions during colder months (p = 0.002. To estimate the incidence of testicular torsion, we have related our findings to data from the last Brazilian census (2010. In 2010, testicular torsion occurred in 1.4:100,000 men in Brazil. CONCLUSIONS:Testicular torsion occurred at an annual incidence of approximately 1.4:100,000 men in Brazil in 2010. Seasonal variations do occur, with a significant increase of events during winter. Our findings support the theory of etiological role of cold weather to the occurrence of testicular torsion. Strategies to prevent these events can be based on these findings.

  2. Thiol protease-specific inhibitor E-64 arrests human epidermoid carcinoma A431 cells at mitotic metaphase

    International Nuclear Information System (INIS)

    E-64-d /ethyl (2S, 3S)-3-[(S)-3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl]oxirane-2-carboxylate/, a membrane-permeant derivative of the thiol protease-specific inhibitor E-64, was found to arrest human epidermoid carcinoma A431 cells at mitotic metaphase. This effect was dose-dependent with a threshold of 20?g/ml in chemically defined culture medium. Cell cycle analysis by flow cytometry showed that the relative proportion of the G2/M population increased 2.5-fold after treatment of the cells with E-64 (100 ?g/ml) for 5 hr. In addition, time-lapse video analysis showed that E-64-treated cells remained at metaphase for an extended period after rounding-up, whereas untreated cells were able to complete mitosis within 42.0 +/- 5.7 min. Some treated cells were able to complete mitosis, while others did not do so within limits of the authors observation. An approach to the molecular basis of this phenomenon, they have shown that several cellular proteins can be labeled by incubation of cells with radioactive E-64-d

  3. Study of the Effect of the Cytotoxic Extract of Bacterium Streptomyces on Epidermoid Malignant Cells of the Oral Cavity

    Directory of Open Access Journals (Sweden)

    M Farahmand

    2004-07-01

    Full Text Available Introduction: It is well known that marine microorganisms have been recognized as an important and untapped resource for novel bioactive compounds. Actinomycetes are gram positive bacteria showing a filamentous growth. They are a group of organisms widespread in nature and play a significant role in the future of drug development. Materials & Methods : Marine bacteria strains of Streptomyces griscoloalbus were isolated from soft coral Sinularia erecta in Persian Gulf. Growth and fermentation character of the Streptomyces griscoloalbus were estimated. Cytotoxic activity of fermentation medium was tested by brine shrimp bioassay. Semi purification on the culture extract was performed. Results: Toxic extract was applied on KB cells ( human epidermoid carcinoma of mouth and results of neutral red test were IC50= 4.19 g/ml from acetone extract and IC 50 = 44.97 g/ml. For methanol extract, cytotologic effects of the acetone extract on KB cells was studied and morphological changes were also studied. Conclusion:The morphological changes in Kb cells due to the cytotoxic extract of the bacteria has made it a good candidate for the production of cytotoxic drugs in the future.

  4. Slide Preparation Method to Preserve Three-dimensional Chromatin Architecture of Testicular Germ Cells

    OpenAIRE

    Namekawa, Satoshi H

    2014-01-01

    During testicular germ cell differentiation, the structure of nuclear chromatin dynamically changes. The following describes a method designed to preserve the three-dimensional chromatin arrangement of testicular germ cells found in mice; this method has been termed as the three-dimensional (3D) slide method. In this method, testicular tubules are directly treated with a permeabilization step that removes cytoplasmic material, followed by a fixation step that fixes nuclear materials. Tubules ...

  5. Mono-(2-Ethylhexyl) Phthalate (MEHP) Promotes Invasion and Migration of Human Testicular Embryonal Carcinoma Cells1

    OpenAIRE

    Yao, Pei-Li; Lin, Yi-Chen; Richburg, John H.

    2012-01-01

    Testicular dysgenesis syndrome refers to a collection of diseases in men, including testicular cancer, that arise as a result of abnormal testicular development. Phthalates are a class of chemicals used widely in the production of plastic products and other consumer goods. Unfortunately, phthalate exposure has been linked to reproductive dysfunction and has been shown to adversely affect normal germ cell development. In this study, we show that mono-(2-ethylhexyl) phthalate (MEHP) induces mat...

  6. Incidental Discovery of Testicular Microlithiasis: What Is the Importance of Ultrasound Surveillance? Two Case Reports

    OpenAIRE

    Barchetti, F; Marco, V.; Barchetti, G.; Pasqualitto, E.; Sartori, A; Glorioso, M.; Gigli, S.; V. Megna; Montechiarello, S.; Boncore, V.; STAGNITTI, A.

    2013-01-01

    Many studies have demonstrated an association between diffuse bilateral testicular microlithiasis (TM) and gonadal and extragonadal germ cell tumors. Nevertheless, it is still uncertain whether ultrasound surveillance is really necessary in patients with TM in the absence of other risk factors such as previous testicular cancer, a history of cryptorchidism or testicular atrophy. We report the cases of a 33- and a 39-year-old man presenting with a retroperitoneal extragonadal tumor. The first ...

  7. Spatial variation and temporal trends of testicular cancer in Great Britain

    OpenAIRE

    Toledano, M B; Jarup, L.; Best, N.; Wakefield, J.; ELLIOTT, P

    2001-01-01

    Increases in testicular cancer incidence have been reported in several countries over a long period. Geographical variability has also been reported in some studies. We have investigated temporal trends and spatial variation of testicular cancer at ages 20–49 in Britain. Temporal trends in testicular cancer incidence were examined, 1974 to 1991 and in mortality, 1981–1997. Spatial variation in incidence was analysed across electoral wards, 1975 to 1991. We used Poisson regression to examine f...

  8. Involvement of epigenetic modifiers in the pathogenesis of testicular dysgenesis and germ cell cancer

    DEFF Research Database (Denmark)

    Lawaetz, Andreas C.; Almstrup, Kristian

    2015-01-01

    cell is a fetal germ cell that has been arrested during development due to testicular dysgenesis. CIS cells retain a fetal and open chromatin structure, and recently several epigenetic modifiers have been suggested to be involved in testicular dysgenesis in mice. We here review the possible involvement...... of epigenetic modifiers with a focus on jumonji C enzymes in the development of testicular dysgenesis and germ cell cancer in men....

  9. Testicular Infarction and Rupture After Blunt Trauma — Use of Diagnostic Ultrasound

    OpenAIRE

    Alistair Pace; Christopher Powell

    2004-01-01

    We report the case of a 23-year-old male who suffered localised testicular infarction and rupture following blunt trauma. This pathology is rare after blunt trauma and has not been previously described in literature. The appearance on ultrasound resembled malignancy, necessitating orchidectomy. An overview of the pathology of testicular trauma as well as its management is given with particular emphasis on the use diagnostic ultrasound in testicular trauma.

  10. Advanced and recurrent testicular rhabdomyosarcoma in a young adult: A rare case report

    Directory of Open Access Journals (Sweden)

    L Purnima Devi

    2015-01-01

    Full Text Available Rhabdomyosarcoma (RMS is one of the most frequent soft tissue sarcomas. Pure testicular RMS is a very rare tumor and a few cases have been reported in the literature. We report a 16-year-old male patient with a painless right testicular swelling who underwent high inguinal orchiectomy and diagnosed as testicular embryonal RMS. The patient had a rare recurrence at the scrotal site with inguinal and retroperitoneal metastasis.

  11. Testicular Involvement in Wegener Granulomatosis: Case Report and Review of the literature

    Directory of Open Access Journals (Sweden)

    Mehmet Nuri TURAN

    2012-05-01

    Full Text Available Wegener granulomatosis (WG is a type of necrotising vasculitis that affects mainly the respiratory tract, paranasal sinuses and the kidneys. Urogenital involvement is rare; mainly affecting the prostate gland. Testicular involvement in WG is exceptional. We report a 50-year-old male patient with hematuria, proteinuria and testicular pain and renal failure diagnosed as WG by testicular and kidney biopsy. We also provide a review of the literature.

  12. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors

    OpenAIRE

    Purdue, Mark P.; Barry I. Graubard; Chanock, Stephen J.; Rubertone, Mark V.; Erickson, Ralph L; McGlynn, Katherine A.

    2008-01-01

    Gene-knockout studies in mice suggest that INHA, encoding a subunit of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal cell tumors. It is not known whether genetic variation in the inhibin pathway also influences susceptibility to testicular germ cell tumors (TGCT), the most common testicular cancer in young men. To address this question, we conducted a case-control analysis (577 cases, 707 controls) of single-nucleotide polymorphisms (SNPs) in...

  13. Canonical Correlation Analyses of Testicular and Body Measurements of Awassi Ram Lambs

    OpenAIRE

    Davis, Michael E.; Ebru Emsen

    2004-01-01

    Nine body measurements and seven testicular measurements were obtained from 41 Awassi fat tailed ram lambs at seven months of age. Canonical correlation analyses were run to identify the associations between testicular and body measurements as two sets of variables. Nine body and seven testicular measurements were used as predictor variables and criterion variables, respectively. For the first four canonical variate pairs, the canonical coefficients ranged from 0.95 to 0.74, and all significa...

  14. Carcinoma epidermoide de pene Penis epidermoidal carcinoma

    Directory of Open Access Journals (Sweden)

    Alfredo Ediel Misiara Álvarez

    2009-10-01

    Full Text Available Se trata de un adulto, blanco, masculino, de 58 años, con antecedentes de hipertensión arterial, y lesiones en el pene desde hace aproximadamente más de veinte años, las cuales fueron aumentando en tamaño, variando su localización. Hace dos años se valoró como un condiloma acuminado, pero no llevó tratamiento. Se valora en nuestro hospital porque veinte días atrás las lesiones tomaron aspecto tumoral, comenzaron a abscedarse, ulcerarse. Se valoró el caso en conjunto con Dermatología, Urología. Después de varios tratamientos antibióticos se logró biopsiar la lesión. El caso es interesante por lo infrecuente de la localización de las lesiones en nuestro paciente y el grado de avance de la enfermedad.It deals with a 58-years-old male, white man, with antecedents of blood hypertension, and increasing lesions in the penis since around 20 years ago, with changing locations. Two years ago it was diagnosed as acuminated condylomas, but it was not treated. The patient attended our hospital because twenty days ago the lesions adopted a tumor like aspect, and began to get abscessed, to ulcerate. The case was evaluated together with Dermatology and Urology. After some antibiotic treatments, it was obtained a biopsy of the lesion. The case is interesting because of the uncommon localization of the lesions in our patient and the increased level of the disease.

  15. Tratamiento laparoscópico del quiste hidatídico hepático Laparoscopic treatment of liver hydatid cysts

    Directory of Open Access Journals (Sweden)

    PEDRO PINTO G

    2011-08-01

    Full Text Available El objetivo es mostrar los detalles técnicos, protocolo de manejo, costos y resultados del tratamiento laparoscópico de quiste hidatídico hepático (QHH. Se presenta un análisis prospectivo y descriptivo de una serie de 31 casos consecutivos de pacientes portadores de QHH operados entre enero de 2006 y enero de 2009, en el Hospital Regional de Coyhaique. Se incluye a todos los pacientes portadores de QHH tipo I, III, los tipo II y IV sintomáticos, menores a 5 cms según la clasificación de la OmS. Previo a la realización de la cirugía se les indicó 15 días de Albendazol y 2 meses en el post-operatorio. La técnica quirúrgica empleada consistió en la evacuación de la membrana parasitaria, resección parcial de la periquística prominente y sutura de las comunicaciones biliares. Siempre se utilizó drenaje. Los 31 pacientes presentaron 40 quistes, 17 de las cuales fueron mujeres, con un promedio de edad de 37 años. El estudio radiológico reveló que el 68,6 de ellos correspondió a quistes univesiculares, siendo únicos en el 74%, localizados principalmente en el lóbulo hepático derecho (68%. Ei tiempo quirúrgico alcanzó a ios 79,83 minutos. Hubo dos conversiones (6,45%, la morbilidad alcanzó al 24%. La estadía promedio fue de 6 días. El período de seguimiento fue de 28 meses, con una recidiva de 3,5%. No hubo mortalidad en esta serie. El costo del tratamiento laparoscópico del QHH promedió los US 2.107. Creemos que la técnica laparoscópica, aplicada con criterio selectivo, es una alternativa útil para el tratamiento de pacientes con hidatidosis hepática, pues sus resultados son comparables a los existentes con cirugía abierta.Background: Laparoscopic surgery is emerging as a useful alternative for the treatment of liver hydatid cysts. Aim: To report technical data, management protocols, costs and results of laparoscopic management of liver hydatid cysts. Material and Methods: Prospective analysis of 31 patients aged 5 to 73 years (17 females, with 40 cysts, operated between 2006 and 2009. All patients received albendazol for 15 days prior to surgery and for 2 months afterwards. Surgical technique consisted in the evacuation of parasite membrane, partial excision of prominent pericystic membrane and suture of biliary communications. Results: Sixty nine percent of cysts were uni-vesicular, 74% were unique and 68% were located in the right lobe. Surgical time was 80 min. Two patients were converted to open surgery and 24% had postoperative complications. Mean hospital stay was six days. Patients were followed for 28 months and in 4% the cyst relapsed. No patient died. The mean cost of laparoscopic treatment was US$ 2.107. Conclusions: Laparoscopic technique is a useful surgical alternative for the treatment of liver hydatid cysts.

  16. A survey of etiologic hypotheses among testicular cancer researchers

    DEFF Research Database (Denmark)

    Stang, A; Trabert, B; Rusner, C; Poole, C; Almstrup, K; Rajpert-De Meyts, E; McGlynn, K A

    2015-01-01

    Basic research results can provide new ideas and hypotheses to be examined in epidemiological studies. We conducted a survey among testicular cancer researchers on hypotheses concerning the etiology of this malignancy. All researchers on the mailing list of Copenhagen Testis Cancer Workshops and...... corresponding authors of PubMed-indexed articles identified by the search term 'testicular cancer' and published within 10 years (in total 2750 recipients) were invited to respond to an e-mail-based survey. Participants of the 8th Copenhagen Testis Cancer Workshop in May 2014 were subsequently asked to rate the...... plausibility of the suggested etiologic hypotheses on a scale of 1 (very implausible) to 10 (very plausible). This report describes the methodology of the survey, the score distributions by individual hypotheses, hypothesis group, and the participants' major research fields, and discuss the hypotheses that...

  17. Gynecomastia caused by testicular irradiation. A case report

    Energy Technology Data Exchange (ETDEWEB)

    Mori, Hiroki; Umeda, Tadashi; Katayama, Ichiro; Nishioka, Kiyoshi [Tokyo Medical and Dental Univ. (Japan). School of Medicine

    1996-09-01

    Gynecomastia in a 20-years-old male is reported. At the age of 2, the patients had contracted acute lymphocytic leukemia (ALL), at which time irradiation for the testicular ALL invasion was performed. This irradiation induced atrophy of the testis. Obesity was first noted when he was 12 years old, after which enlargement of the bilateral breasts occurred at 14 years of age. When he turned 19, supplementary testosterone therapy was initiated to counter the gynecomastia, but it proved ineffective. Thus, a total mastectomy was performed with free nipple grafting. Pathologically, inspected mammary tissue specimens revealed mammary ducts in a fibrous stroma that had encompassed lobules of adipose tissue. The findings in this case suggest that the testicular irradiation had induced primary hypogonadism and that this had resulted in gynecomastia and obesity. (author)

  18. The role of radioimmunodetection in the management of testicular cancer

    Energy Technology Data Exchange (ETDEWEB)

    Javadpour, N.; Kim, E.E.; DeLand, F.H.; Salyer, J.R.; Shah, U.; Goldenberg, D.M.

    1981-07-03

    Five patients with testicular cancer received an intravenous injection of between 1 and 2.5 mCi of iodine 131-labeled antibody to human chorionic gonadotropin (HCG) or alpha-fetoprotein (AFP), followed by total-body photoscanning to visualize areas of abnormal radioactivity. Blood-pool and nontarget sites of radioactivity were reduced by subtracting the images derived by injection of technetium Tc 99m-labeled components from the iodine 131 scans. The HCG-immune scintiscans proved helpful in tumor localization and in the selection of appropriate therapy, while the AFP scan presented corroborative evidence of widespread tumor. Elevated serum levels of these two markers did not hinder successful tumor detection and localization by this method of radioimmunodetection. Cancer radioimmunodetection with antibodies to HCG and to AFP appears to be a useful procedure for the pretreatment and posttreatment evaluation of patients with testicular cancer and can reveal sites of tumor not detected by other methods.

  19. Testicular germ cell tumors: Molecular genetic and clinicomorphological aspects

    Directory of Open Access Journals (Sweden)

    M. V. Nemtsova

    2015-03-01

    Full Text Available Testicular tumors are the most common form of solid cancer in young men. According to the 2004 WHO classification, testicular germ cell tumors (TGCT may present with different histological types. Embryonic cells of varying grade may be a source of TGCT and the occurrence of this type of tumors is directly related to the formation of a pool of male sex cells and gametogenesis. The paper gives information on mo- lecular stages for the process of formation of male sex cells in health, as well as ways of their impairments leading to TGCT. An investigation of the profiles of gene expression and the spectrum of molecular damages revealed genes responsible for a predisposition to the sporadic and hereditary forms of TGCT. The paper presents the current molecular genetic and clinicomorphological characteristics of TGCT. 

  20. Testicular Feminization: Report of Three Cases in a Family

    Directory of Open Access Journals (Sweden)

    H Moayyeri

    2002-10-01

    Full Text Available Case of the complete syndrome of testicular feminization were reported early in the 19th century, but it was in 1950 that Lawson recognized the etiology in a patient with amenorrhea and failing pubic and axillary hair, which was unresponsive to testosterone therapy. The prevalence of androgen resistance is estimated to be between 1:20.000 and 1:64.000 men and the complete form is the 3rd most common cause of primary amenorrhea. Testicular feminization is transmitted as X-linked recessive trait. In this article, we report on three siblings in a family with complete form of androgen insensitivity. The first case, the youngest of the siblings, was recognized by an inguinal hernia operation. The diagnosis was established chromosomal analysis, hormonal assays, sonography, and pathological examination after laparotomy.

  1. Catalytic properties of testicular hyaluronidase after gamma-irradiation

    International Nuclear Information System (INIS)

    The effect of gamma-irradiation on ovine testicular hyaluronidase was studied in aqueous solution. Following irradiation, hyaluronidase is inhibited, and the kinetics of inhibition follow a pattern in which Ksub(m) and Vsub(max) decline as radiation dose is increased. It was indicated that the binding affinity of the residual activity of hyaluronidase with substrate is enhanced and depends upon radiation damage. Effects of various agents such as pH, salts, PCMB and glutathione on irradiated hyaluronidase have been compared with non-irradiated enzyme. The irradiated hyaluronidase was more sensitive to inhibition by CuSO4 than the non-irradiated enzyme. The residual activity after irradiation is less refractory to FeCl3 inhibition and less sensitive to NaCl stimulation compared to non-irradiated hyaluronidase. pH response curves of ovine testicular hyaluronidase show two maxima which become more evident after irradiation. (orig.)

  2. Testicular function in a birth cohort of young men

    DEFF Research Database (Denmark)

    Hart, R J; Doherty, D A; McLachlan, R I; Walls, M L; Keelan, J A; Dickinson, J E; Skakkebaek, N E; Norman, R J; Handelsman, D J

    2015-01-01

    testis volume (P < 0.001), lower sperm concentration (P = 0.012) and total sperm output (P = 0.030) and lower serum inhibin B levels (P = 0.046). Smoking, alcohol intake, herniorrhaphy, an epididymal cyst, medication and illicit drugs were not associated with any significant semen variables, testicular...... obesity may impact on human testicular function, most common drug exposures and the presence of epididymal cysts appear to have no or minimal adverse impact. WHAT IS KNOWN ALREADY: The majority of previous attempts to develop valid reference populations for spermatogenesis have relied on potentially....... However, there has been some concern that a surprisingly high proportion of young men may have semen variables that do not meetall the WHO reference range criteria for fertile men, with some studies reporting that up to one half of participants have not meet the reference range for fertile men. Reported...

  3. Human testicular peritubular cells: more than meets the eye.

    Science.gov (United States)

    Mayerhofer, Artur

    2013-05-01

    In healthy men, several layers of inconspicuously flat cells and extracellular matrix (ECM) proteins build the wall of the seminiferous tubules. The cells of this wall, peritubular cells, are not well characterized. They are smooth-muscle-like and contractile and transport immotile sperm, a function important for male fertility. However, their full functional importance, especially their potential contribution to the paracrine regulation of the male gonad, is unknown. In men with impaired spermatogenesis, the architecture of the tubular wall is frequently altered. Deposits of ECM and morphological changes of peritubular cells imply that functions of peritubular cells may be fundamentally altered. To be able to study human peritubular cells and their functions, a culture method was established. It is based on small biopsies of patients with obstructive azoospermia but normal spermatogenesis (human testicular peritubular cells, HTPCs) and non-obstructive azoospermia, impaired spermatogenesis, and testicular fibrosis (HTPCFs). Results obtained from cellular studies and parallel examinations of biopsies provide insights into the repertoire of the secretion products, contractile properties, and plasticity of human peritubular cells. They produce ECM components, including the proteoglycan decorin, which may influence paracrine signaling between testicular cells. They may contribute to the spermatogonial stem cell niche via secreted factors. They are regulated by mast cell and macrophage products, and in response produce factors that can fuel inflammatory changes. They possess a high degree of plasticity, which results in hypertrophy and loss of contractile abilities. The data collectively indicate important roles of inconspicuous testicular peritubular cells in human male fertility and infertility. PMID:23431272

  4. Hormonal Regulation of Testicular Steroid and Cholesterol Homeostasis

    OpenAIRE

    Eacker, Stephen M.; Agrawal, Nalini; Qian, Kun; Dichek, Helén L; Gong, Eun-Yeung; Lee, Keesook; Braun, Robert E.

    2007-01-01

    The male sex steroid, testosterone (T), is synthesized from cholesterol in the testicular Leydig cell under control of the pituitary gonadotropin LH. Unlike most cells that use cholesterol primarily for membrane synthesis, steroidogenic cells have additional requirements for cholesterol, because it is the essential precursor for all steroid hormones. Little is known about how Leydig cells satisfy their specialized cholesterol requirements for steroid synthesis. We show that in mice with a uni...

  5. Real-time tissue elastography for testicular lesion assessment

    OpenAIRE

    Goddi, Alfredo; Sacchi, Andrea; Magistretti, Giovanni; Almolla, Joan; Salvadore, Maurizio

    2011-01-01

    Objectives To assess the ability of Real-time Elastography (RTE) to differentiate malignant from benign testicular lesions. Methods In 88 testicles ultrasound identified 144 lesions, which were examined by RTE. Elasticity images of the lesions were assigned the colour-coded score of Itoh (Radiology 2006), according to the distribution of strain induced by light compression. RTE findings were analysed considering shape (nodular/pseudo-nodular), size (11 mm) and score (SC1-5) of the lesions. Re...

  6. Structural analysis of testicular appendices in patients with cryptorchidism

    OpenAIRE

    Guilherme D. Tostes; Suelen F. Costa; João P. de Carvalho; Waldemar S Costa; Francisco J.B. Sampaio; Favorito, Luciano A.

    2013-01-01

    Objectives Report the incidence and structure of testicular appendices (TAs) in patients with cryptorchidism, comparing their incidence with epididymal anomalies (EA) and patency of the vaginal process (PVP) and analyzes the structure of TAs. Material and Methods We studied 72 testes of patients with cryptorchidism (average of 6 years), and 8 testes from patients with hydroceles (average of 9 years). We analyzed the relations among the testis, epididymis and PVP and prevalence and histology o...

  7. Testicular Vein Syndrome and Its Treatment with a Laparoscopic Approach

    OpenAIRE

    Arvind, Nand Kishore; Singh, Onkar; Gupta, Shilpi Singh

    2011-01-01

    Background and Objectives: Testicular vein syndrome (TVS) is a rare cause of ureteral obstruction. Only 5 previous cases are on record in the literature, and no review exists on this topic to date. Laparoscopic treatment has never been mentioned in the management of TVS. Materials and Methods: We reviewed the literature related to this unusual entity to clarify the preoperative evaluation and the management of TVS. For this purpose, the data related to all the 5 cases previously reported so f...

  8. Sexual Function in Men Treated for Testicular Cancer.

    OpenAIRE

    Eberhard, Jakob; Ståhl, Olof; Cohn-Cedermark, Gabriella; Cavallin-Ståhl, Eva; Giwercman, Yvonne; Rylander, Lars; Eberhard-Gran, Malin; Kvist, Ulrik; Fugl-Meyer, Kerstin S; Giwercman, Aleksander

    2009-01-01

    ABSTRACT Introduction. Testicular germ cell cancer (TGCC) patients may be at risk of developing sexual dysfunction after treatment. Aim. The aim of this study was to assess the prevalence of sexual dysfunctions in TGCC patients 3 to 5 years after treatment, and relate findings to biochemical hypogonadism, treatment intensity, and the expected prevalence in the Swedish male population. Methods. A questionnaire study on 129 consecutive TGCC patients 3 to 5 years post-treatment was performed. Co...

  9. Increased stomach cancer risk following radiotherapy for testicular cancer

    OpenAIRE

    Hauptmann, M; Fossa, S. D.; Stovall, M.; van Leeuwen, F. E.; Johannesen, T.B.; Rajaraman, P.; Gilbert, E. S.; Smith, S.A.; Weathers, R E; Aleman, B.M.P.; Andersson, M; Curtis, R E; Dores, G. M.; Fraumeni, J.F.; Hall, P.

    2014-01-01

    Background: Abdominal radiotherapy for testicular cancer (TC) increases risk for second stomach cancer, although data on the radiation dose–response relationship are sparse. Methods: In a cohort of 22 269 5-year TC survivors diagnosed during 1959–1987, doses to stomach subsites were estimated for 92 patients who developed stomach cancer and 180 matched controls. Chemotherapy details were recorded. Odds ratios (ORs) were estimated using logistic regression. Results: Cumulative incidence of sec...

  10. Adolescent and adult risk factors for testicular cancer

    OpenAIRE

    McGlynn, Katherine A; Trabert, Britton

    2012-01-01

    The incidence of testicular cancer has been increasing over the past several decades in many developed countries. The reasons for the increases are unknown because risk factors for the disease are poorly understood. Some research suggests that exposures in utero or in early childhood are likely to be important in determining an individual's level of risk. However, other research suggests that exposure to various factors in adolecence and adulthood are also linked to the development of testicu...

  11. Endocrinological aspects in the therapy of testicular affections in children suffering from acute leukemias

    International Nuclear Information System (INIS)

    Orchidectomy or testicular irradiation with 24 to 30 Gy are recommended for testicular involvement in boys with acute lymphoblastic leukemia. But, recommended radiation doses for the only occulty involved other testis differ, i.e. they range from 12 to 24 Gy. Low dose (12 or 15 Gy) 'preventive' testicular irradiation was delivered to 5 of 14 patients; only one of these 5 experienced a further testicular relapse. According to our observation, in contrast to higher doses, the dose limitation allows spontaneous pubertal development including normal testosteron production and normal development of the masculine stature. (author)

  12. An unusual case of intra-abdominal testicular torsion: Role of laparoscopy

    Directory of Open Access Journals (Sweden)

    Alfonso Papparella

    2013-01-01

    Full Text Available The authors report a case of intra-abdominal testicular torsion, where laparoscopy has been useful for diagnosis and surgical management. A boy was presented with a left impalpable testis. Laparoscopy revealed a twisted spermatic cord at the inlet pelvis, which ended in a testicular remnant located in the sub-umbilical area. After orchiectomy, the pathologist confirmed testicular atrophy. Diagnosis of intra-abdominal testicular torsion should be considered in patients with impalpable testis and abdominal pain, but could not be excluded in those with no symptoms.

  13. Scintigraphy and color duplex doppler sonography to detect testicular vascular disturbances in varicocele

    International Nuclear Information System (INIS)

    The detection of a varicocele represent an important part of the infertility workup because these dilated veins may contribute to the infertility problem, and the problem may be correctable. The aim of this work was to evaluate scrotal scintigraphy as a screening measure of varicocele and to study testicular vascular disturbances that may be associated with this illness. This study was conducted on a total of fifty infertile patients with varicocele and eleven normal controls. Patients were grouped into four groups according to clinical classification. All patients and controls were subjected to thorough history and full examination. Using color duplex Doppler sonography, diameters of the pampiniform plexus of veins, testicular arterial diameters and blood velocities were measured in relation to testicular size. Then, scrotal scintigraphy was performed by injection of 20 mCi of 99mTc Pertechnetate I.V. to detect testicular perfusion and radioactive uptake. We have detected 89.5% sensitivity and 90.9% specificity of scintigraphy compared to color duplex Doppler ultrasonography Significant decreases in arterial blood velocity and testicular perfusion were detected specially with large varicoceles which showed also, significant decrease in testicular arterial diameters compared to control. These changes could be correlated to decrease of testicular size. In conclusion, scintigraphy is a simple non invasive, with potential exposure, screening test of varicocele. There are decreases in testicular arterial perfusion, arterial blood velocity and to some extent arterial diameter. These changes may be correlated to testicular growth retardation in this possibly correctable cause of male infertility (au)

  14. [Segmental testicular infarction. Unusual complication of intravenous immunoglobulin therapy for multifocal motor neuropathy].

    Science.gov (United States)

    Rüb, J; Rehmann, R; von Landenberg, N; Roghmann, F; Stude, P; Tegenthoff, M; Noldus, J; Pastor, J

    2015-10-01

    We describe the previously unknown case of segmental testicular infarction as an iatrogenic complication of intravenous immunoglobulin administration in a patient with multifocal motor neuropathy. PMID:26303740

  15. PADRÃO ULTRASSONOGRÁFICO DO PARÊNQUIMA, MEDIASTINO E TÚNICAS TESTICULARES EM BOVINOS JOVENS DA RAÇA NELORE

    Directory of Open Access Journals (Sweden)

    Diogo José Cardilli

    2010-12-01

    Full Text Available The aim of the present study was to demonstrate the ultrasonographic patterns of the testicles parenchyma, mediastinum and tunics in young Nellore bulls with absence of echogenicity and relative density changes. Testes of 111 animals underwent clinical and ultrasonographic evaluation at 9, 13, and 15 months of age. Testicular parenchyma presented uniform pattern at low echogenicity. Positive correlation was found between age and testicular mediastinum. Testicular tunics were distinguished only in presence of fluid. The results of this research contribute with andrologic evaluation, allowing early detection of testicular disorders.

  16. Testicular choriocarcinoma: diagnosed on cervical lymph node biopsy.

    Science.gov (United States)

    Abbasi, Nadeem Zia; Zahur, Zainab; Sheikh, Abdul Samad; Khan, Amjad Aziz; Ahmed, Fayyaz; Memon, Khalid Hussain; Ali, Furqan; Jeilani, Asif; Fatima, Tetheer; Khan, Kamran; Gul, Attia

    2013-12-01

    Choriocarcinoma is a very rare germinal testicular tumour and in literature its incidence has been reported to be 0.3% of all germinal testicular tumours. An important tumour marker is serum beta-hCG which not only helps in establishing diagnosis but also in assessing response to chemotherapy. In this study we present a case of testicular choriocarcinoma, who presented with abdominal pain, cough, generalized weakness and left sided cervical mass. Incisional biopsy of cervical mass was performed. Histopathology revealed metastatic choriocarcinoma. Serum beta-hCG levels were 1227 ng/mL. Patient received intravenous cycles of PEB (cisPlatin, Etoposide, Bleomycin) chemotherapy but he had progressive disease both radiologically and on tumour marker monitoring. He was planned for salvage chemotherapy but was lost to follow up there after. It is concluded that in males, choriocarcinoma carries a very dismal prognosis and a very poor response to chemotherapy and radiotherapy; surgery has no role in the management. PMID:24397105

  17. Varicocele Repair Improves Testicular Histology in Men with Nonobstructive Azoospermia

    Science.gov (United States)

    Ustuner, Murat; Yilmaz, Hasan; Yavuz, Ufuk; Ciftci, Seyfettin; Saribacak, Ali; Aynur, Bahri Serkan; Yasar, Hikmet; Culha, Mustafa Melih

    2015-01-01

    Objective. To determine the histopathological differences after varicocele repair in testicular tissue in males with nonobstructive azoospermia. Methods. Between 2009 and 2014, 45 men with complete azoospermia and palpable varicocele, presenting with primary infertility of at least 1 year, undergoing varicocele repair at our institution were selected for the study. A standard systematic testicular 6-core Tru-Cut biopsy was performed during varicocele repair. Other biopsies were obtained from each testicle of all patients at the time of microscopic sperm extraction procedure. Results. Nineteen patients were selected for the study. Testicular biopsy specimens were classified as Sertoli cell only on preoperative histopathological analysis in 14 patients. After varicocele repair, focal spermatogenesis (n = 3) and late maturation arrest (n = 2) were found in these patients. Average Johnsen score was significantly increased after varicocelectomy (P = 0.003). Motile sperm was found in one patient on postoperative semen analyses and in 10 more patients in the microscopic sperm extraction procedure. Preoperative high serum follicle stimulating hormone level and venous reflux were significantly and negatively correlated with the increase in average Johnsen score (P varicocele repair. PMID:26601110

  18. Alterations in Bones of Prepubertal Rats with Testicular Torsion

    Directory of Open Access Journals (Sweden)

    Levent YILDIZ

    2008-04-01

    Full Text Available Objective: Testicular torsion is one of the leading causes of hypogonadism among children. We aimed to evaluate the effects of testicular torsion in prepubertal rats using densitometry and a histopathological study in adulthood.Materials and Methods: Thirty-two prepubertal male Wistar albino rats were randomly divided into four equal groups. The rats in the SHAM group underwent scrotal incision only. In the torsion group rats, both testes were torsioned 720° in a clockwise direction. In the torsion/detorsion group, the testes were detorsioned after four days of torsion. The torsion/orchidectomy rats underwent orchidectomy on the fourth day subsequent to bilateral torsion. Three months after surgery, bone mineral density (BMD and content (BMC were measured by DXA and bone cortex thickness (BCT measurements were performed histopathologically.Results: The lowest values of BMD and BMC were in rats with torsion (mean 0.075 g/cm2 and 0.290 g, and highest in the SHAM group (mean 0.142 g/cm2 and 0.488 g. The SHAM group had a mean of 388.52 mm BCT, whereas the torsion group had a mean of only 220.16 mm (p<0.05. Conclusion: Bilateral testicular torsion in prepubertal rats may lead to bone loss in adulthood. Detorsion may prevent the negative effects of torsion on bones in rats. Turk J Phys Med Rehab 2008;54:1-3.

  19. Cystic rete testis with testicular dysplasia in a rabbit.

    Science.gov (United States)

    Chambers, James K; Uchida, Kazuyuki; Murata, Yousuke; Watanabe, Ken-ichi; Ise, Kenichiro; Miwa, Yasutsugu; Nakayama, Hiroyuki

    2014-05-01

    An 8-year-old intact rabbit was presented to a veterinary hospital with a complaint of enlarged left scrotum. Histological examination revealed a single large cyst adjacent to an efferent ductule-like tissue. The cyst wall was composed of monolayer cuboidal cells surrounded by dysplastic testicular tissue, and the seminiferous tubules were not developed at all. The epithelial cells of the cyst possessed the same properties as the epithelial cells of the rete testis that were positive for CD 10 and cytokeratin 18, negative for p63 and lacked desmin-positive muscular layer. The dysplastic testicular tissue was composed of two types of cells: small pleomorphic cells with a condensed nucleus (sex cord-like cells) and large round cells with cytoplasmic lipid droplets (Leydig cells). Both of these cells were positive for vimentin and melan A that are consistent with the staining pattern of Sertoli cells and Leydig cells. This is the first report to demonstrate cystic rete testis with testicular dysplasia in animals. PMID:24430659

  20. Stage 1 testicular seminoma; Seminomes testiculaire de stade 1

    Energy Technology Data Exchange (ETDEWEB)

    Gross, E.; Champetier, C.; Zaccariotto, A.; Duberge, T. [Departement de radiotherapie, hopital de la Timone, 13 - Marseille (France); Pointreau, Y. [Service de radiotherapie, centre regional universitaire de cancerologie Henry-S.-Kaplan CHU de Tours, Hpital Bretonneau, 37 - Tours (France); Chauvet, B. [Institut Sainte-Catherine, 84 - Avignon (France)

    2010-07-01

    Testicular cancer is rare, representing only 1 % of malignant tumors, but the most common cancer in young men, 15 to 35 years. Adjuvant radiotherapy after orchidectomy in testicular seminoma stage I, reduces risk of relapse. It aims to eradicate micro-metastatic disease in lymph drainage territories. In the case of adjuvant radiotherapy, the relapse-free survival of 96 % with an overall survival of 98 % at 5 years. The irradiation volume is made up of lymph nodes paraaortic which it is possible to add the ipsilateral renal hilum to the testicular lesion. The current recommended dose is 20 Gy in 10 fractions and 2 weeks, usually delivered by two antero-posterior beams. The acute toxicities, mainly represented by nausea and diarrhea are usually quickly resolved to the end of irradiation. Regarding toxicities long-term, preservation of semen should be considered after surgery because of fear of infertility post-treatment. The risk of second cancer associated with exposure to ionizing radiation, albeit small, is especially important to consider these patients to significant life expectancy. Nevertheless, developments in radiotherapy techniques and lower doses and irradiated volumes can probably reduce this risk further. (authors)

  1. Multiple vascular anomalies involving renal, testicular and suprarenal arteries

    Directory of Open Access Journals (Sweden)

    Suresh Rao

    2015-09-01

    Full Text Available Knowledge of variations of blood vessels of the abdomen is important during operative, diagnostic and endovascular pro- cedures. During routine dissection of the abdominal cavity, we came across multiple vascular anomalies involving renal, suprarenal and testicular arteries. The left kidney was supplied by two renal arteries originating together from the abdomi- nal aorta, and the right kidney was supplied by two accessory renal arteries, one of which was arising from the right renal artery and the other one from the aorta (about 2 inches below the origin of the renal artery. Accessory renal veins were present on both sides. The right testicular artery was arising from the lower accessory renal artery. The left testicular artery was looping around the inferior tributary of the left renal vein, whereby forming a sharp kink. The left middle suprarenal artery was diving into three small branches; the upper two branches were supplying the left suprarenal gland, whereas the lower branch was supplying the left kidney. Furthermore, detailed literature and the clinical and surgical importance of the case are discussed. [Arch Clin Exp Surg 2015; 4(3.000: 168-171

  2. Ecotoxicology and Testicular Damage (Environmental Chemical Pollution: A Review Ecotoxicología y Daño Testicular. (Contaminación Química Ambiental: Revisión

    Directory of Open Access Journals (Sweden)

    Eduardo Bustos-Obregón

    2008-12-01

    Full Text Available This review briefly considers the testicular damage elicited by environmental chemical pollution. It includes a short comment on environmental toxicology as an introduction to environmental chemical pollution, highlighting the importance of this current field of study and its impact on male reproductive health. Furthermore an experimental animal model addressing the effect of organophosphorated agropesticides as a testicular toxicant is presented. Moreover two relevant chemical contaminants and their effect on the testis, such as the classical case of lead and the rarely reported case of Boron on spermatogenesis, are considered. Additionally, the subject of biosentinel species and their relevance for the monitoring of pollution in aquatic and/or terrestrial ecosystems is considered. In conclusión, it should be stressed that environmental health is closely related to the reproductive health of all living beings.Esta revisión considera el daño testicular provocado por la contaminación química ambiental. Incluye un breve comentario sobre toxicología ambiental a modo de introducción respecto a la polución química ambiental y destaca la importancia de este campo de estudio actual y su impacto sobre la salud reproductiva masculina. Además se presenta un modelo experimental animal concerniente al efecto de agropesticidas organofosforados como tóxicos testiculares. Se consideran dos contaminantes químicos relevantes y su efecto en el testículo como son el clásico caso del plomo y el menos conocido caso del boro y sus efectos sobre la espermatogénesis. También se trata el tema de las especies biocentinelas y su importancia para el monitoreo de la evolución de ecosistemas acuáticos y/o terrestres. En conclusión, es necesario insistir que la salud medioambiental está íntimamente relacionada con la salud reproductiva de todos los seres vivos.

  3. MR imaging with Gd-DTPA enhancement in the testicular ischemia in rat model: evaluation of testicular viability

    International Nuclear Information System (INIS)

    To find the magnetic resonance (MR) imaging patterns and to determine the viability in normal, infarcted and reversible ischemic testis of the rat. Fifteen Sprague-Dawley rats were examined and they were divided into four groups. Group 1 was the control group, group 2 had a complete testicular artery ligation, group 3 had a complete ligation with reperfusion after 1 hour and group 4 had a complete ligation with reperfusion after 12 hours. All four groups were imaged every 5 minutes for 30 minutes. Delayed MR imaging was obtained every 30 minutes for 90 minutes. Two follow-up MR images were performed in all groups at a one-week interval. The signal intensity was measured in the normal testis, ischemic testis, and in muscle, water and fat in every rat at each time, with the phantom attached near the scrotum during the scanning. The signal intensities were analyzed statistically. On initial and 2-week follow-up examinations, the pattern of change differed among four groups (p<0.001). Group 1 and Group 3 did not show any marked change over time at each examination. Group 3 showed strong enhancement at the first week follow-up. Group 2 showed steadily delayed enhancement at each examination. Group 4 had same pattern with the Group 2 with higher enhancement intensity in parallel. MR images with Gd-DTPA could be useful for the diagnosis of damaged testicular tissue and for the determination of testicular viability

  4. Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: evidence from 20 adult patients with signs of maldevelopment of the testis

    DEFF Research Database (Denmark)

    Skakkebæk, Niels Erik; Holm, Mette; Hoei-Hansen, Christina; Jørgensen, Niels; Rajpert-De Meyts, Ewa

    2003-01-01

    Based on a well established association between testicular cancer and undescended testis and more recent publications on epidemiological links between these disorders and male infertility, we proposed the existence of a testicular dysgenesis syndrome (TDS). In most cases TDS presents with impaired...... of semen sampling and testicular histology. In conclusion, our study of 20 patients with various reproductive abnormalities provided evidence that TDS is a real clinical entity. We speculate that most of these abnormalities are caused by adverse environmental effects rather than specific gene...

  5. Quiste dentígero que causa deformación facial en un niño. Presentación de un caso

    Directory of Open Access Journals (Sweden)

    Juan Carlos Quintana Díaz

    2012-09-01

    Full Text Available Se presenta un caso interesante de un niño de 13 años que acude a la consulta de Cirugía Máxilofacial por presentar asimetría facial y bucal, además de obstrucción nasal del lado de la deformidad. Después de realizar exámenes de laboratorio y radiográficos se lleva sala de cirugía para realizar la exéresis del canino superior derecho retenido, enuclear la extensa área radiolucida a los rayos X y se reconstruye el defecto óseo residual con Hidroxiapatita en gránulos HAP-200, posteriormente se realiza estudio histopatológico. El diagnóstico definitivo corroboró el presuntivo (quiste dentígero. El paciente evolucionó de forma excelente desapareciendo la deformidad facial y los demás síntomas preoperatorios. El examen radiográfico post-operatorio mostró una excelente reconstrucción y osteo-integración del material empleado.

  6. HAMARTOMA HIPOTALAMICO ASOCIADO A DOS QUISTES ARACNOIDEOS: A PROPOSITO DE UN CASO HYPOTHALAMIC HAMARTOMA ASSOCIATED WITH ARACH-NOID CYST: REPORT OF A CASE

    Directory of Open Access Journals (Sweden)

    Diana Martín H

    2008-01-01

    Full Text Available Los hamartomas hipotalámicos son heterotopias de tejido nervioso que se asemejan a la sustancia gris del hipotálamo. Pueden causar pubertad precoz y/o crisis gelásticas. Presentamos el caso de una paciente que a los 9 meses de edad comenzó desarrollo púberal y que en la resonancia magnética craneal se objetivó un hamartoma hipota-lámico asociado a dos quistes aracnoideos, uno en fosa craneal media y otro en región pineal, asociación que es muy infrecuente.Hypothalamic hamartomas are heterotopias of the nervous tissue which are similar to the grey mat-ter of the hypothalamus. They may cause precocious puberty and/or gelastic seizures. We present the case of a patient who began her pubertal development at the age of 9 months. Cranial magnetic resonance ima-ging showed a hypothalamic hamartoma associated with middle cranial fossa and pineal región arachnoid cysts, a very rare association.

  7. Clinical case: Testicular cancer with metastases (Caso clínico: Cáncer testicular con metástasis

    Directory of Open Access Journals (Sweden)

    Valderrama-Gómez Ricardo Alfredo

    2011-11-01

    Full Text Available Testicular cancer is the most common malignancy in men aged15-45 years. As a result of therapeutic advances in recent decadesand the integration of multimodal treatment, testicular cancer isnowadays one of the most curable malignancies. Non-seminomaGerminal cells tumor type includes embryonic carcinoma, choriocarcinoma,teratoma and yolk sac tumor. Despite of the long-termsurvival is favorable, multimodal treatment of NSGCT is constantlyevolving and incorporating new paradigms.It is described a patient in working age and fertile, who presents aclinical picture of +/- 2 years of evolution, presenting a left testicularpainless mass, the which increased progressively associated toweight lost. He presented abdominal pain without fever or historyof irritative urinary symptoms. This pathology is rare in our context,seen 3-4 cases per year in Viedma Hospital, with an incidenceof 0,8 per 100000 inhabitants/year in Bolivia, so it is important topresent it, so it can be diagnosed in less advanced stages. -RESUMEN: El cáncer testicular es la patología maligna más común en los hombresentre 15-45 años. Como resultado de los adelantos terapéuticosen las últimas décadas y la integración del tratamiento multimodal,el cáncer testicular es ahora una de las neoplasias más curables. ElTumor de Células Germinales de tipo No Seminoma (NSGCT, porsus siglas en ingles incluye el carcinoma embrionario, el coriocarcinoma,el teratoma y el tumor del saco vitelino. A pesar de ser favorablela supervivencia a largo plazo, el diagnóstico generalmentees un estadio tardio, por su presentación inicial asintomática.Ahora describimos a un paciente en edad laboral y fértil, el cualse caracterizo por un cuadro clínico de +/- 2 años de evolución,presentando una masa testicular izquierda, no dolorosa, que aumentóde volumen progresivamente asociada a pérdida de peso, dolorabdominal, sin alzas térmicas, ni antecedentes de sintomatologíairritativa urinaria.Esta patología es poco frecuente en nuestro medio, observándoseaproximadamente 3-4 casos por año en el Hospital Clínico Viedma,con una incidencia de 0.8 por cada 100.000 habitantes/año en Bolivia.Por lo que creemos es importante la presentación del mismo,para que no se lo subdiagnostique y pueda ser diagnosticado enestadio menos avanzados.

  8. Ultrassonografia testicular em caprinos jovens da raça Alpina

    Directory of Open Access Journals (Sweden)

    L.R.B. Carazo

    2014-04-01

    Full Text Available Objetivou-se com este trabalho observar as mudanças do parênquima testicular de acordo com o fotoperíodo e com a faixa etária dos animais por meio da ecotextura testicular e a viabilidade do uso do ultrassom na avaliação testicular. Foram utilizados 4 animais desde o 6° até o 13° mês de idade. Os exames ecográficos foram realizados a cada 15 dias para avaliar a ecotextura testicular. O parênquima testicular mostrou-se moderadamente ecogênico e homogêneo. Foi observado comportamento semelhante na ecotextura testicular durante o período de avaliação, sendo maior no 8º mês de idade, quando o volume testicular também foi maior; tais mudanças foram relacionadas com o fotoperíodo da região. A avaliação ultrassonográfica dos testículos mostrou-se um método eficiente, capaz de detectar as mudanças no parênquima testicular ao longo do tempo, e como ferramenta alternativa para diferenciação de condições normais e patológicas em caprinos.

  9. TB or not TB?: a case of isolated testicular TB with scrotal involvement.

    LENUS (Irish Health Repository)

    Bhargava, A

    2009-06-01

    Despite the genitourinary tract being the most common site affected by extrapulmonary TB, isolated testicular TB remains a rare clinical entity. In patients with co-morbidities such as hepatic impairment, treatment proves a challenge, as first-line hepatotoxic pharmaceuticals are contraindicated. Here, we report a case of isolated testicular TB with scrotal involvement, on a background of hepatic dysfunction.

  10. Anti-MIC2 as a tool in examination of testicular biopsies

    DEFF Research Database (Denmark)

    Visfeldt, J; Cortes, Dina; Thorup, J M; Byskov, A G

    1999-01-01

    a "negative reaction" of germ cells, contrasting with the stained Sertoli cells. The material comprised: 44 specimens of testicular parenchyma taken at time of surgery for cryptorchidism from 24 cryptorchid boys with nonpalpable testes and 14 testicular biopsies from 13 cryptorchid patients with...

  11. Sperm Concentration, Testicular Volume and Age Predict Risk of Carcinoma In Situ in Contralateral Testis of Men with Testicular Germ Cell Cancer

    DEFF Research Database (Denmark)

    Rud, Camilla Nymann; Daugaard, Gedske; Rajpert-De Meyts, Ewa; Skakkebæk, Niels Erik; Petersen, Jørgen Holm; Jørgensen, Niels

    2013-01-01

    We investigated whether semen quality or some easily attainable clinical parameters might be used to estimate the risk of contralateral carcinoma in situ in patients with unilateral testicular germ cell tumors....

  12. DOUBLE RIGHT TESTICULAR ARTERI ES WITH ITS EMBRYOLOGICAL BASIS: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Anita Shriram

    2015-07-01

    Full Text Available Variations in the origin of arteries in the abdomen are very common but with the advent of new operative and laparoscopic techniques within the abdominal cavity, the anatomy of the abdominal vessels has assumed much more clinical importance. During routine dissection for MBBS of the abdominal cavity, we came across double right testicular arteries in a middle aged male cadaver. Testicular arterial morphology deviating from its normal anatomy is a serious concern, as diagnostic approaches in male infertility and varicocele can be often linked with its associated vascular anomaly. The origin and course of the testicular artery must be carefully identified in order to preserve normal blood circulation and prevent testicular atrophy. Radiologists, urologists and oncologists should be famil iar with testicular artery variants in order to provide an accurate diagnosis during pre - operative studies. Knowledge of this variation will help to avoid clinical complications especially during radiological examination and/or surgical approaches in abdom inal region.

  13. Testicular arteries systematization based on different levels of scrotal configuration in caprines Sistematização da artéria testicular em caprinos segundo a configuração escrotal

    OpenAIRE

    Mônica Marco de Almeida; Antônio Chaves de Assis Neto; Alexandra Klindline Penno; Airton Mendes Conde Júnior; Danilo Jose Ayres de Menezes; Gabriel Ribas Pereira; Laurita Martins de Azevêdo; Maria Acelina Martins Carvalho

    2008-01-01

    The objective of this study was to describe the distribution of testicular arterial vessels in caprines with different degrees of scrotal division. Scrotal configurations were classified as follows; Group I: scrotum without bipartition; Group II: scrotum showing a ventral division until the middle of the testis; and, Group III: scrotal separation extended beyond the middle of the testis. A colored vinyl acetate solution was injected into 60 testicular arteries (30 pairs). After, the samples w...

  14. Testicular parenchymal abnormalities in Klinefelter syndrome: a question of cancer? Examination of 40 consecutive patients

    Directory of Open Access Journals (Sweden)

    Giacomo Accardo

    2015-02-01

    Full Text Available Klinefelter syndrome (KS is a hypergonadotropic hypogonadism characterized by a 47, XXY karyotype. The risk of testicular cancer in KS is of interest in relation to theories about testicular cancer etiology generally; nevertheless it seems to be low. We evaluated the need for imaging and serum tumor markers for testicular cancer screening in KS. Participants were 40 consecutive KS patients, enrolled from December 2009 to January 2013. Lactate dehydrogenase (LDH, alpha-fetoprotein (AFP, and beta-human chorionic gonadotrophin subunit (β-HCG serum levels assays and testicular ultrasound (US with color Doppler, were carried out at study entry, after 6 months and every year for 3 years. Abdominal magnetic resonance (MR was performed in KS when testicular US showed micro-calcifications, testicular nodules and cysts. Nearly 62% of the KS had regular testicular echotexture, 37.5% showed an irregular echotexture and 17.5% had micro-calcifications and cysts. Eighty seven percent of KS had a regular vascular pattern, 12.5% varicocele, 12.5% nodules 1 cm. MR ruled out the diagnosis of cancer in all KS with testicular micro calcifications, nodules and cysts. No significant variations in LDH, AFP, and β-HCG levels and in US pattern have been detected during follow-up. We compared serum tumor markers and US pattern between KS with and without cryptorchidism and no statistical differences were found. We did not find testicular cancer in KS, and testicular US, tumor markers and MR were, in selected cases, useful tools for correctly discriminating benign from malignant lesions.

  15. TESTICULAR CANCER – THE SUCCESS OF MULTIMODAL THERAPY

    Directory of Open Access Journals (Sweden)

    L. Miron

    2006-01-01

    Full Text Available Testicular neoplasia constitutes a chapter of particular interest in oncology, given its increased curability in comparison with most solid tumors. Early diagnosis is important because it allows the patients to be treated in the first stages of the disease, in which morbidity associated with therapy is minimal, and increased survival represents certitude. The medical staff, as well as the general population, must be advised upon suggestive signs and symptoms, and also on the imaging characteristics of such cancers (ultrasound and CAT scans being in the spotlight, so that the period of time until confirmation of the diagnosis (by pathology exam – which in turn influences therapy decision – is obtained may be as short as possible. Surgery represents a very important component of multimodal therapeutic strategy for patients diagnosed with testicular cancer, both for low/volume tumors and for the more advanced stages of disease. Surgical interventions (orchiectomy, retroperitoneal lymph node resection with or without sympathic nerve preservation, resection of singular metastases contribute decisively to the high percentage of long term cures, and can play a role in increasing the survival of patients with chemoresistant metastatic disease. Chemotherapy is mandatory in the treatment of locally advanced and metastasis seminomatous germ cell tumors (GCT. This may be seen also as an option to annihilate possible pathology diagnostic errors (mostly due to lack of tumour marker dosing which determine a non-seminomatous GCT to be treated as a seminoma, thus greatly diminishing therapeutic efficacy. There are several chemotherapeutic agents with extremely efficient activity on seminomatous testicular tumours, but the etoposide/cisplatin protocol remains still the gold standard. Non-seminomatous GCTs have a lesser response to chemotherapy and therefore a higher relapse rate and a poorer prognosis.

  16. Refined testicular dosimetry and radiobiology in radionuclide therapy

    International Nuclear Information System (INIS)

    The full text of the publication follows. The testes are one of the most radiosensitive organs. They constitute an important critical target tissue both for external and internal exposure during diagnostic or therapeutic use of radionuclides. The testis consists of an egg-shaped tissue containing a large number of lobules. These are occupied by one to four seminiferous tubules, where the spermatogenesis takes place, i.e. the complex process where germ cells proliferate and transform into spermatozoa. The testicular cells have different sensitivity to radiation with the highest sensitivity of the undifferentiated spermatogonia close of the basal cell layer, and lowest sensitivity of the more mature sperm cells migrating towards the lumen. Exposure of the testis may occur due to radiopharmaceutical administration in patients either for therapy or diagnostic purposes, which may result in considerable high absorbed dose to the testis and may harm the testicular germ cells. In general the mean absorbed dose to the whole testis is estimated, which has been reported for different radionuclides and radiopharmaceuticals in the literature. However, due to the difference in radiosensitivity of the germ cells the absorbed doses to each type of cells in the seminiferous epithelium is of importance for a radiobiological interpretation. Testicular dosimetry on the cellular level is a complex matter and has not yet been addressed. The aim of this project was to design a small-scale anatomy model for calculation of S-factors (Gy MBq-1) for different source-target combinations, i.e. the interstitial tissue and different germ cells of the seminiferous epithelium. Based on this small-scale anatomy model it should be possible to estimate radiobiological effects based on radioactivity distribution determined by autoradiography, calculated differentiated absorbed doses, and known radiosensitivity of the different germ cells. The novel small-scale anatomy model will be presented and its impact on radiation protection and dose planning prior to radionuclide therapy will be discussed. (authors)

  17. Impacto de la dieta sobre la inducción de infección con quistes de Giardia lamblia en ratas Sprague-Dawley The effect of malnourishment on the development of giardiosis in Sprague-Dawley rats

    Directory of Open Access Journals (Sweden)

    Martha Elvia Díaz-Cinco

    2002-07-01

    Full Text Available Objetivo. Evaluar el efecto de la desnutrición en la inducción de la giardiosis con diferentes concentraciones de quistes de Giardia lamblia utilizando como modelo animal ratas Sprague-Dawley. Material y métodos. Es un estudio experimental efectuado entre 1995 y 1999, en el Centro de Investigación en Alimentación y Desarrollo, de la ciudad de Hermosillo, estado de Sonora, México, y cuya muestra estuvo integrada por dos grupos de 6 a 8 unidades experimentales, las cuales recibieron dos tipos de dieta y cinco tratamientos con diferente concentración de inóculo de quistes de Giardia lamblia. Durante la fase experimental se monitoreó la excreción de quistes, ganancia de peso, consumo de alimento, análisis del contenido intestinal y daños macro y microscópicos en mucosa intestinal. El tratamiento estadístico de los datos consistió en análisis de varianza, y de residuales cuando fue necesario. Resultados. En los animales alimentados con una dieta que cubre sus requerimientos nutricionales (DN se observó que es posible provocar la infección con 60 quistes, mientras que en los animales desnutridos (dieta DLN la concentración que se requiere es de únicamente seis quistes para establecer daños a nivel de mucosa intestinal. Conclusiones. La ganancia de peso monitoreada durante los 10 días de ensayo no resultó ser un buen indicador de la infección por Giardia lamblia. El porcentaje de infección depende de la concentración de quistes inoculados y del estado de nutrición de los animales evaluados.Objective. To assess the effect of malnutrition on the development of giardiosis in Sprague-Dawley rats, using different inoculum sizes of Giardia lamblia cysts. Material and Methods. An experimental study was conducted between 1995 and 1999 at Centro de Investigación, Alimentación y Desarrollo (Center for Research, Food, and Development, in Hermosillo, Sonora, Mexico. The study population consisted of two groups of six to eight experimental units that were fed two different diets and inoculated five different concentrations of Giardia lamblia cysts. Data were collected on excretion of cysts, weight gain, food intake, bowel contents, and macro and microscopic lesions in the intestinal mucosa. Statistical analysis consisted of analysis of variance and residuals. Results. Animals fed with a diet meeting nutritional requirements required an infecting inoculum of 60 cysts, while malnourished rats required only six cysts to develop mucosal lesions. Conclusions. Weight gain monitored during ten days was not a good indicator of Giardia lamblia infection. Infection depended on cyst inoculum size as well as on the nutritional status of the tested animals.

  18. Laparoscopic treatment of testicular torsion in a puppy.

    Science.gov (United States)

    Carr, Jennifer G; Heng, Hock Gan; Ruth, Jeffrey; Freeman, Lynetta

    2015-01-01

    A 6 mo old male puppy was presented as an emergency for an acute onset of lethargy, ptyalism, and vomiting. On physical examination, the dog was painful on abdominal palpation. A torsed intra-abdominal testis was diagnosed via abdominal ultrasonography and radiography. Laparoscopy was used to identify and remove the torsed testis. The dog recovered uneventfully and was described as doing well by the owners at the 6 mo follow-up telephone contact. This is the first report of an abdominal testicular torsion treated with laparoscopy. PMID:25654442

  19. A case of true hermaphroditism presenting as a testicular tumour.

    Science.gov (United States)

    Ceci, Michelle; Calleja, Edward; Said, Edith; Gatt, Noel

    2015-01-01

    True hermaphroditism represents only 5% cases of all of disorders of sexual differentiation (DSD) and usually present in early childhood with ambiguous genitalia. Occasionally, cases might present later on in adolescence with problems of sexual maturation. Our case report presents a true hermaphrodite with normal male phenotype that presented as a left testicular mass, two years after being diagnosed with Sertoli cell only syndrome in the contralateral testis. Histological examination of the left testis showed ovarian, fallopian tube, myometrial, endometrial, and epididymal tissue. This combination of findings is found in approximately one-third of true hermaphrodites, but it is very rare to present clinically as an inguinoscrotal mass. PMID:25774314

  20. Immunoreactivity examination of patients with testicular tumours treated with radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Stefanits, K.; Kuhn, E.; Csere, T.

    1985-02-01

    Results of the immunoreactivity study of 72 patients receiving radiotherapy are presented. Tuberculin and DNCB (2,4 dinitrochlorobenzol) reactivity tests were performed before, during and 3 years after the radiation therapy and at the time when metastases appeared. The number of positive reactions decreased slightly in both tuberculin and DNCB groups, though not significantly. Metastatic patients showed a significant decrease of reactivity against DNCB as compared with the results obtained before the treatment. In 5,6% of patients herpes zoster was registered. No other infections occured. It was found that immunosuppression caused by the radiation treatment does not influence the later fate of patients with testicular tumours. 41 refs.

  1. Suspected testicular torsion – urological or general surgical emergency?

    Science.gov (United States)

    Tydeman, C; Davenport, K; Glancy, D

    2010-01-01

    INTRODUCTION Suspected testicular torsion (TT) is a surgical emergency, usually requiring urgent scrotal exploration. Provision of urology on-call cover varies widely between hospitals and often falls under the remit of the general surgical team. The purpose of this study was to investigate whether the management of suspected TT differed between urology (UT) and surgical (ST) trainees in the Severn and South West Peninsula Deaneries. SUBJECTS AND METHODS An on-line questionnaire (SurveyMonkey.com) was sent to all UT and ST within the Deaneries. Questions covered training, on-call cover, intra-operative management and knowledge of complications following testicular fixation. Responses were analysed using an Excel spreadsheet and GraphPad statistical package. RESULTS Responses were received from 26/31 UT and 43/52 ST throughout 17 hospitals. Only three hospitals had separate middle-grade specialist urology cover. Scrotal exploration was taught by urologists to 72% of UT compared with 40% of ST (P = 0.012, Fisher's exact test). Variability in the number of operations performed, supervision and management of true TT was insignificant. However, ST were more likely to fix a normal testicle either in the absence of other pathology (53% vs 28%) or with a twisted appendix testis (42% vs 15%) than UT (P = 0.045 and P = 0.032, respectively). UT were more aware of evidence regarding chronic pain (47% vs 14%) and infertility (53% vs 18%) following testicular fixation than ST (P = 0.005 and P= 0.003, respectively). Medicolegally, 76% of UT would inform the on-call consultant prior to operation compared with 45% of ST(P = 0.012). DISCUSSION ST are significantly more likely to fix a normal testicle than UT (and then usually only on the affected side), contrary to best-practice. This variation may be due to the different sources of training received by the two groups. Knowledge of possible chronic pain and infertility following testicular fixation may also affect management. CONCLUSIONS Due to the variation, we suggest urology departments should draw up guidelines for management; trainees should be encouraged to discuss the case pre-operatively with the consultant; core surgical training should include a urology placement. PMID:21047450

  2. Radiation therapy for the various subtypes of testicular seminoma

    International Nuclear Information System (INIS)

    From 1964 to 1975 total of 53 consecutive patients with testicular seminoma were treated with irradiation post orchiectomy. The 3 year recurrence free survival, no evidence of disease (N.E.D.) was 97% for Stage I, and 93% for Stage II patients; 3 of 4 patients with Stage III disease were N.E.D. at 3 years. Elective irradiation to the mediastinum and supraclavicular area is indicated for Stage II but not for Stage I. Spermatocytic and anaplastic subtypes have at least the same prognosis as classical seminoma and should be treated the same way. Two cases of seminoma with trophocarcinoma (embryonal carcinoma) are reported

  3. Endocrinological late effects after chemotherapy for testicular cancer.

    OpenAIRE

    Berger, C. C.; Bokemeyer, C.; Schuppert, F.; Schmoll, H. J.

    1996-01-01

    Type and extent of endocrinological alterations were studied in long-term disease-free survivors after cisplatin-based chemotherapy for testicular cancer. A total of 63 patients with a median age of 30 (19-53) years, and median follow-up of 42 (16-128) months were included. Elevated serum follicle-stimulating hormone (FSH) levels were found in 63% of patients, 24% showed pathologically elevated luteinising hormone (LH) levels with normal and 10% with subnormal testosterone levels. The degree ...

  4. Medical image of the week: metastatic testicular cancer

    Directory of Open Access Journals (Sweden)

    Debo M

    2014-06-01

    Full Text Available A 30 year-old man with metastatic embryonal testicular cancer was admitted to the hospital with severe abdominal pain. A contrast enhanced CT of the abdomen demonstrated large metastatic burden throughout the liver and the left adrenal gland (Figures 1 and 2. The mass arising from the left adrenal gland caused significant mass effect. The left kidney was compressed, though without hydronephrosis, and the spleen was displaced laterally. Renal and hepatic functions were preserved. His pain was controlled with opioids and oral steroids with significant improvement.

  5. ERα and ERβ in mouse testicular cells and sperm

    Czech Academy of Sciences Publication Activity Database

    Dostálová, Pavla; Děd, Lukáš; Pěknicová, Jana

    Praha : Biotechnologický ústav, 2013 - (Pěknicová, J.). s. 22-23 [XIX. Symposium imunologie a biologie reprodukce s mezinárodní účastí. 23.05.2013-25.05.2013, Třešť] R&D Projects: GA ČR(CZ) GAP503/12/1834 Institutional research plan: CEZ:AV0Z50520701 Keywords : Estrogen receptor α β * Estrogen receptor β * Testicular cells * Spermatogenesis Subject RIV: EB - Genetics ; Molecular Biology

  6. Technical relapsed testicular irradiation for acute lymphoblastic leukemia

    International Nuclear Information System (INIS)

    Testicular irradiation in children suffering from acute lymphoblastic leukemia presents difficulties in relation to daily positioning, dosimetry for dose homogenization of complex geometry and volume change during irradiation thereof. This can lead to significant deviations from the prescribed doses. In addition, the usual techniques often associated with unnecessary irradiation of pelvic simphysis, anus and perineum. This, in the case of pediatric patients, is of great importance, since doses in the vicinity of 20 Gy are associated with a deviation of bone growth, low testosterone levels around 24 Gy and high rates of generation of second tumors. To overcome these problems we propose a special restraint in prone and non-coplanar irradiation.

  7. Testicular dysgenesis syndrome: foetal origin of adult reproductive problems

    DEFF Research Database (Denmark)

    Wohlfahrt-Veje, Christine; Main, Katharina M; Skakkebaek, Niels Erik

    2009-01-01

    testis cancer and in infertile men. The histological evidence includes immature seminiferous tubules with undifferentiated Sertoli cells, microliths and Sertoli-cell only tubules. Dysgenetic testes often have an irregular ultrasound pattern, where microliths may also be visible. Our current hypothesis is...... that maternal exposure to endocrine disrupting chemicals may contribute to the pathogenesis of TDS. Animal experiments have shown that all TDS symptoms, except testicular cancer, can be induced by foetal exposure to anti-androgenic chemicals. However, the cause of TDS in humans remains to be determined....

  8. Testicular descent: INSL3, testosterone, genes and the intrauterine milieu

    DEFF Research Database (Denmark)

    Bay, Katrine; Main, Katharina M; Toppari, Jorma; Skakkebæk, Niels E

    2011-01-01

    risk of infertility and testicular cancer in adulthood. Although some cases of isolated cryptorchidism in humans can be ascribed to known genetic defects, such as mutations in INSL3 or RXFP2, the cause of cryptorchidism remains unknown in most patients. Several animal and human studies are currently...... underway to test the hypothesis that in utero factors, including environmental and maternal lifestyle factors, may be involved in the etiology of cryptorchidism. Overall, the etiology of isolated cryptorchidism seems to be complex and multifactorial, involving both genetic and nongenetic components....

  9. Resección de quiste pilonidal por radiofrecuencia: una mejor opción para la resección amplia y cicatrización con herida abierta Radiofrequency resection of pilonidal cyst: a better option for a wide resection and healing by open wound

    OpenAIRE

    Pravin J. Gupta

    2006-01-01

    Antecedentes: A pesar de la variedad de técnicas quirúrgicas descritas para el tratamiento del quiste pilonidal, ninguna ha merecido reconocimiento como modalidad óptima. En el presente artículo el autor describe una técnica para la resección del quiste o seno pilonidal utilizando un aparato de radiofrecuencia. Actualmente se realiza un estudio aparte para comparar los resultados de esta técnica de resección amplia y cicatrización por granulación. Materiales y métodos: De 44 pacientes con enf...

  10. Conservative treatment by irradiation of epidermoid cancers of the anal canal: prognostic factors of tumoral control and complications

    International Nuclear Information System (INIS)

    We analyzed in a retrospective series of patients treated by conservative irradiation for an epidermoid cancer of the anal canal (ECAC) the prognostic factors of locoregional control (LRC), survival, late severe complications (LSC), and sphincter conservation (SC). Methods and Materials: From 1976 until 1994, 118 patients presenting with an ECAC were conservatively treated (mean age, 65 years). According to the 1987 International Union Against Cancer (TNM) classification, they were: 19 T1, 70 T2, 22 T3, 7 T4, 94 N0, and 24 N1-3. The treatment started with external beam irradiation (EBI) (36 Gy in 3 weeks or 45 Gy in 5 weeks). Concomitant chemotherapy (5-fluorouracil and mitomycin C) was delivered to 31 patients. Two months later, a boost of 20 Gy was delivered by interstitial 192Ir brachytherapy to 101 patients and EBI in 5. Twelve other patients had an abdominoperineal resection (APR). The mean follow-up was 6 years. Results: At 5 years the overall survival was 60%, and specific survival (SS) was 75%; it was 94% for TI, 79% for T2, 53% for T3, and 19% for T4. In multivariate analysis, tumor size (?4 cm), node involvement, and no response to the EBI were factors of poor prognosis for SS. Thirty-two locoregional recurrences occurred of which 21 were local recurrences in the 106 patients treated by a conservative schedule. Only tumor size and response to the EBI were prognostic factors on multivariate analysis for local and LRC. A total of 17 patients presented with LSC (Grade 3, 16 patients; and Grade 4, 1 patient), which was treated by APR in 4 patients and colostomy in 11 (of which 7 were definitive). The only significant prognostic factor for LSC in the multivariate analysis was the total extrapolated response dose of irradiation. The definitive rate of SC after conservative treatment in cured patients was 100% for T1, 82% for T2, 58% for T3, and 100% for T4. Since 1989, improvements of the technique have allowed reduction of the LSC in maintaining the same local control. Conclusion: The results of this series are similar to those of the literature. The confirmation of pretherapeutic prognostic factors related to response to the treatment should allow us to adapt the therapeutic intensity for each case to obtain better tumor control, with as few sequelae as possible, to yield a better rate of SC

  11. Epidermoid carcinomas of the anal canal treated with definitive radiation therapy in a series of 305 patients

    International Nuclear Information System (INIS)

    Purpose. - To identify prognostic factors and treatment toxicity in a series of epidermoid cancers of the anal canal without evident metastasis. Patients and methods. - Between June 1972 and January 1997, 305 patients (pts) were treated with curative-intent radiation therapy (RT). The T-stages according to the 1987 UICC classification were: 26 T1, 141 T2, 104 T3, and 34 T4. There were 49 pts with nodal involvement at presentation. Pretreatment anal function scoring according to our in-house system was: 22 scored 0, 182 scored 1, 74 scored 2, 7 scored 3. 11 scored 4, and 9 not available pts. The treatment started with external beam RT (EBRT) in 303 pts (median dose: 45 Gy). After a rest period of 4 to 6 weeks, a boost of 20 Gy was delivered by EBRT in 279 pts and by interstitial 192Ir brachytherapy (Bcy) in 17 pts. Seven pts received only one course of EBRT (mean dose: 49.5 Gy) and 2 pts were treated with interstitial 192Ir Bcy alone (55 and 60 Gy, respectively). concomitant chemotherapy (5-fluoro-uracil and either mitomycin C or cisplatin) was delivered to 19 pts. Mean follow-up was 103 months. Results. - At the end of RT local tumor clinical complete response (cCR) rate was 80%. Out of 61 non responders or local progressive tumors 27 (44%) were salvaged with abdomino-perineal resection (APR). The rate of local tumor relapse (LR) was 12%. Out of 37 LTR, 20 (54%) were salvaged with APR and one with interstitial 192Ir Bcy. The overall local tumor control (LC) rate with or without salvage local treatment was 84%. LC rate with a good anal function scoring (score 0 and 1) was 56.5%0. Among 181/186 available pts who preserved their anus, 94% had a good anal function scoring. For a subgroup of 15 pts with length tumor 38 days vs ≤38 days, P=0.0025), pretreatment anal function scoring (0 vs 1 vs 2 vs 3 vs 4, P =4.4 10-6), and cCR after the end of RT (no complete response vs complete response, P =2.5 10-14). Conclusion. - We confirm excellent results with RT in T1 and T2 lesions. However, chemoradiotherapy should be preferred to improves survival free. of colostomy with a good anal sphincter function for tumors more than or equal to 2 cm in length and locally advanced tumors. (author)

  12. Resección laparoscópica de feocromocitoma y quiste pancreático en un paciente con enfermedad de Von Hippel-Lindau / Single-stage laparoscopic adrenalectomy and pancreatic cyst exsicion in a patient with Von Hippel-Lindau disease

    Scientific Electronic Library Online (English)

    O., Castillo; M., Kerkebe; G., Vitagliano; L., Arellano.

    2007-03-01

    Full Text Available Introducción: La enfermedad de Von Hippel-Lindau es una condición autosómica dominante, caracterizada por la presencia de hemangioblastomas cerebelosos, angiomas retinianos, quistes y tumores viscerales. Reportamos una experiencia en la resección por vía laparoscópica de un feocromocitoma y quiste p [...] ancreático en un paciente con enfermedad de Von Hippel-Lindau. Material y método: Paciente de 20 años de edad, sexo masculino, con historia de enfermedad de Von Hippel-Lindau, a quien en estudio de hipertensión arterial se le encuentra una masa suprarrenal izquierda de 5 cm. de diámetro y la evaluación bioquímica orienta hacia un feocromocitoma. Es llevado a adrenalectomía laparoscópica y como hallazgo intraoperatorio se encuentra un quiste de 3 cm. en relación a la cola del páncreas, el cual se reseca en el curso de la misma intervención. Resultados: El tiempo operatorio fue de 120 minutos. No se registraron complicaciones intra o postoperatorias. El sangrado quirúrgico fue Abstract in english Introduction: Von Hippel-Lindau disease is a dominant autosomic hereditary condition, characterized by cerebellar hemangioblastomas, retinal animas and visceral cysts and tumors. We report a case of a patient with Von Hippel-Lindau in which we performed a single-stage laparoscopic adrenalectomy for [...] a pheochromocytoma and pancreatic cyst excision. Patient and method: A 20 year old male patient with Von Hippel Lindau disease underwent laparoscopic adrenalectomy for a 5 cm left adrenal mass. A 3 cm cystic lesion was found of the tail of the pancreas and was resected completely laparoscopically during the same operative procedure. Results: Total operative time was 120 minutes. There were no operative or postoperative complications. Blood loss was

  13. Quiste broncogénico de la pared torácica: Caso clínico y revisión de la literatura Bronchogenic cyst in the chest wall

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    David Schnettler R.

    2003-09-01

    Full Text Available Los quistes broncogénicos se ubican en la mayoría de los casos en la cavidad torácica, en relación con el árbol bronquial, en la periferia del parénquima pulmonar o en el mediastino. Sin embargo, existen casos infrecuentes en que el quiste se localiza en la pared torácica, principalmente en el tejido celular subcutáneo presternal, en la región cervical y el abdomen. Se postula que la ubicación fuera de la cavidad torácica ocurre por migración, o pinzamiento del tejido pulmonar normal durante la fusión de los procesos esternales o diafragmáticos. En este artículo, se presenta como caso clínico, un paciente 10 años de edad, de sexo masculino, que presentó una lesión nodular presternal, confirmada como quiste broncogénico en el estudio histológico. Se revisa la literatura al respecto y se discute el enfoque diagnóstico y terapéutico más adecuado a esta patologíaThe majority of bronchogenic cysts are found in the thoracic cavity, principally the bronchial tree, the peripheral lung parenchyma or the mediastinum. However, infrequently the cysts are found in the thoracic wall, mainly in the presternal subcutaneous tissues, the cervical region or the abdomen. It is postulated that cysts found outside the thoracic cavity occur by migration or by entrapment of normal pulmonary tissue during the embryonic fusion of the sternum or diaphragm. We present a case of a 10 year old boy who presented with a nodular presternal lesion, histologically confirmed as a brochogenic cyst. We review the literature and discuss the diagnosis and most adequate treatment

  14. "11Hydroxylas deficient form of congenital adrenal hyperplasia with bilateral testicular tumors and true precocious puberty (A case report "

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    "Moayeri H "

    2002-08-01

    Full Text Available The development of testicular masses in male patients with congenital adrenal hyperplasia due to 21 hydroxylase deficiency has been recognized for many years. We present here the eighth and ninth reported patient with bilateral testicular tumors associated with 11 hydroxylase deficiency. They were two brothers aged 7.5 and 5 yr. who had bilateral testicular tumors and diagnosed because of signs and symptoms of true precocious puberty and high blood pressure. The patients testicular enlargement is suggestive of bilateral testicular adrenal rest.

  15. Tomografía Computarizada de Haz Cónico como Instrumento Complementario de Diagnóstico y Planeamiento Quirúrgico de Quiste Dentígero: Reporte de un Caso / Cone-Beam Computed Tomography as Complementary Tool in Diagnosis and Surgical Planning of Dentigerous Cyst: Case Report

    Scientific Electronic Library Online (English)

    Maria Augusta Portella Guedes, Visconti; Rafael Binato, Junqueira; Francielle Silvestre, Verner; Abílio Augusto Sobrinho, Rodrigues; Karina Lopes, Devito; Renato Francisco, Visconti Filho.

    2014-04-01

    Full Text Available El quiste dentígero es una de las patologías óseas que más frecuentes en el maxilar y la mandíbula. Se evidencia radiográficamente como una imagen radiolúcida y unilocular en la mayoría de los casos. Generalmente es detectado en exámenes de rutina o cuando se investiga la presencia de dientes no eru [...] pcionados. El quiste dentígero aparece principalmente en las tres primeras décadas de vida, con crecimiento lento y asintomático. Los terceros molares,así como dientes supernumerarios, pueden estar relacionados con su formación, sin embargo, su etiopatología no es totalmente conocida. La descompresión, marsupialización y la enucleación son las principales formas de tratamiento, pero algunos criterios deben ser considerados, como tamaño del quiste, edad del paciente, proximidad con estructuras anatómicas nobles e importancia clínica del diente involucrado. Para que se establezca un correcto diagnóstico y plan de tratamiento es esencial la utilización de exámenes complementarios de calidad, siendo, actualmente, la tomografía computarizada de haz cónico el más completo y preciso método de diagnóstico por imagen empleado en estas lesiones. El objetivo de este estudio fue resaltar, por medio de la presentación de un caso clínico, la importancia de la tomografía computarizada de haz cónico en el diagnóstico y planeamiento quirúrgico de un quiste dentígero asociado a un diente no erupcionado. Abstract in english The dentigerous cyst is one of the most frequently found in the jaws. They present themselves radiographically as radiolucent images and more commonly unilocular. They are usually observed at routine checkups or when investigating the presence of unerupted teeth. The dentigerous cyst occurs mainly i [...] n the first three decades of life, their growth is slow and asymptomatic. The third molars, as well as supernumerary teeth may be involved with the formation of a dentigerous cyst, but its pathogenesis is still not fully known. Decompression, marsupialization and enucleation are the main forms of treatment, but some criteria must be considered for the treatment plan, such as cyst size, age, proximity to noble anatomical structures and clinical importance of the tooth involved.In order to establish a correct diagnosis and treatment plan is essential to make use of complementary exams and now a days the cone beam computed tomography is the most complete and accurate method in diagnostic imaging used in these situations. Therefore, the aim of this study was to highlight, through the presentation of a clinical case, the importance of cone beam computed tomography in the diagnosis and treatment planning of a dentigerous cyst.

  16. Control químico del Nematodo quiste Heterodera trifolii en clavel miniatura Chemical control of the cyst nematode, Heterodera trifolii in miniature carnation

    Directory of Open Access Journals (Sweden)

    Marroquin Alicia

    1991-12-01

    Full Text Available Una de las enfermedades en el cultivo del clavel recientemente registradas en Colombia es el nemátodo quiste, Heterodera trifolii. Un aumento del marchitamiento vascular ocasionado por Fusarium oxysporumof. sp. dianthi se ha observado en algunas fincas afectadas por los dos patógenos. La investigación se realizó para evaluar el efecto de varios productos químicos en el control del nemátodo, en un invernadero comercial con clavel miniatura de la variedad Red Baron. Los fumigantes DD-metilisotiocianato, Dazomet y Metan sodio se aplicaron al suelo antes de la siembra, solos y en combinación con tres nemáticidas no fumiqantes Aldicarb, Carbofuran y Oxamil, en tres épocas de aplicación. Los fumigantes fueron máseficientes para la reducción de la población del nemátodo en el suelo que los nematicidasno fumigantes. El mejor tratamiento fue DD-metilisotiocianato con una reducción del 52% de la población de quistes viables y de 38% en la población de larvas en el suelo, un adelanto de 15 días en la cosecha, un aumento del 9% en rendimiento y del 19% en ingresos netos, en comparación con el Testigo no tratado. Entre los nematicidas no fumigantes, los mejores tratamientos fueron Aldicarb y Carbofuran aplicados en el momento de la siembra y Oxamil aplicado 30 días después de la siembra. La combinación de los fumigantes y de los nematicidas no fumigantes no mejoró el control del nemátodo, el rendimiento y la calidad de las flores, pero si aumentó notablemente los costos de producción.
    One of the diseases recently registered on carnation in Colombia is the cystnematode caused by Heterodera trifolii. An increase of the vascular wilt was observed in some farms affected by the two pathogens. A trial was carried out in a commercial greenhouse with miniature carnation of the variety Red Baron. The fumigants DD memethylisothiocianate, Dazomet and Methamsodium applied to the soil before planting were used alone and in combination with three non fumigant nematicides Aldicarb, Carbofuranand Oxamyl, at three different times for the control of the nematode. The fumigants were more efficient than the non fumigant nematicides for the reduction of the population of the nematode in the soil. The best treatment was DD Methylisothiocianate with a 52% reduction of the viable cysts population and 38% reduction of the larvae population in the soil, a reduction of 15 daysin harvesting time, a 9% increase in yield and 19% increase in net income, as compared with the untreated control. Among the three nonfumigant nematicides, the best treatments were Aldicarb and Carbofuran applied atplanting time. Oxamyl applied 30 days afterplanting showed similar results. The cornbination of the fumigants with the non fumigant nematicides did not improuve the nematode control, yield and quality of the flowers. Combination of the two types of nematicides increased the production costs.

  17. Hidatidosis retroperitoneal secundaria a quiste hidatídico de localización hepática Retroperitoneal hydatidosis secondary to hepatic hydatid cyst

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    Katherina A Vizcaychipi

    2012-12-01

    Full Text Available La hidatidosis es una enfermedad de distribución mundial, producida por un platelminto parásito del género Echinococcus. El caso que se presenta corresponde a una paciente con una tumoración fluctuante en el espacio retroperitoneal lumbar, secundaria a un quiste hepático. El diagnóstico inicial de certeza fue dado por el hallazgo de ganchos rostelares de protoescólices en el líquido aspirado de un absceso. Este trabajo describe el cuadro clínico, el diagnóstico y el tratamiento médico-quirúrgico de esta paciente. Se analiza cómo la elaboración de un diagnóstico certero requiere de un análisis adecuado de los antecedentes epidemiológicos, las manifestaciones clínicas, los estudios de imágenes y las pruebas de laboratorio, ya que el conjunto de estos datos confirman el caso.Hydatid disease in a worldwide zoonosis. It is caused by a parasitic platyhelminth of the genus Echinococcus. We present a patient with a fluctuating lumbar tumor in the retroperitoneal space, secondary to a hepatic cyst. The initial diagnosis was made by identification of rostellar hooks from protoscoleces in the fluid aspirated from the abscess. We herein describe the clinical manifestations, diagnosis and medical and surgical treatment of this unusual case and conclude that the development of an accurate diagnosis required a proper analysis of the patient's epidemiological history, clinical manifestations, imaging studies and laboratory tests. A multidisciplinary approach and differential diagnosis is paramount to be able to establish a cause of the disease to deliver appropriate treatment.

  18. Quiste dentígeno gigante en una niña: Presentación de un caso Giant dentigerous cyst in a girl: Case report

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    Juan Carlos Quintana Díaz

    2007-06-01

    Full Text Available Se presenta un caso interesante de una niña de 13 años que acude a la consulta de Cirugía Maxilofacial por presentar asimetría facial y bucal, además de referir diplopia y obstrucción nasal del lado de la deformidad. Después de realizar exámenes de laboratorio, radiográficos y tomografía axial computadorizada (TAC, se lleva al salón de operaciones para realizar extracción del tercer molar superior izquierdo retenido en posición invertida, enuclear la extensa área radiolúcida a los rayos X y radiopaca a la tomografía y posteriormente se realiza estudio histopatológico. El diagnóstico definitivo corroboró el presuntivo (quiste dentígeno . La paciente evolucionó de forma excelente; desaparecieron la deformidad facial y los demás síntomas preoperatorios.An interesting case of a 13 year-old girl comes to Maxillofacial Surgery consultation because she has facial and buccal asymmetry; she also refers diplopia and nasal obstruction on the side of the deformity. After carrying out laboratory exams, radiographic studies and computerized axial tomography (TAC, she was taken to the operating room to receive an extraction of the third left superior molar retained in inverted position, and to have retrieved the extensive rays- X radiolucid and radiopaque area at tomography and later on she underwent a histopathological study. The definitive diagnosis corroborated the presumption of dentition cyst. The patient evolved in an excellent way; her facial deformity and other preoperative symptoms disappeared.

  19. VAB-3 combination chemotherapy of metastatic testicular cancer.

    Science.gov (United States)

    Reynolds, T F; Vugrin, D; Cvitkovic, E; Cheng, E; Braun, D W; O'Hehir, M A; Dukeman, M E; Whitmore, W F; Golbey, R B

    1981-08-15

    The initial response and long-term follow-up of 74 evaluable patients who received combination chemotherapy for metastatic nonseminomatous testicular cancer are reported. Patients were treated with a protocol (VAB-3) including vinblastine, actinomycin-D, bleomycin, and cis-dichlorodiammine platinum (DDP). VAB-3 alone caused complete remission (CR) in 54% (40/74) and partial remission (PR) in 26% (1974). Five patients with less than CR to chemotherapy achieved CR following surgical excision of residual mature teratoma after starting VAB-3 protocol, resulting in an overall CR rate of 61% (45/74). With a minimum follow-up of 24+ months, and a median follow-up of 35+ months for those still living, 45% (33/74) of the patients are living free of evidence of disease, 4% (3/74) are living with disease, and 51% (38/74) are dead. Response to VAB-3 protocol was examined with respect to performance status, histology, prior therapy, extent of disease, tumor markers, and duration of disease from diagnosis. No one died because of toxicity of VAB-3, and life-threatening toxicity was uncommon. Long survival is significantly associated (P less than 0.001) with achievement of CR. The treatment goal for metastatic testicular cancer is cure. The achievement of CR, using aggressive combination chemotherapy and surgery, is essential in reaching this goal. PMID:6168360

  20. Lymph node staging in malignant testicular germ cell tumors

    International Nuclear Information System (INIS)

    Imaging procedures are important in the initial staging and subsequent management of testicular germ cell tumors on account of the differing stage-dependent options for therapy. While the diagnosis of advanced tumors gives no cause for controversial discussion the situation in the clinical stage 1 of germ cell tumors is more ambiguous. The lymph node status is only assessed correctly in about 70% of the patients using the currently available methods since metastases in normally large lymph nodes are not detected on slice images. Although most clinical experience has been gained with computed tomography (CT), magnetic resonance imaging (MRI) offers an equally efficient diagnostic procedure. The significance of positron emission tomography with 18-fluorodoxyglucose (FDG-PET) appears to be limited on account of the absence of accumulation in lymph node metastases of the differentiating teratoma. Sonography and lymphography have not proved to be useful for retroperitoneal lymph node diagnosis. The present review presents and discusses the current value of the available imaging procedures for staging and follow-up of malignant testicular germ cell tumors in relation to modern therapy regimens. (orig.)

  1. Vasculite testicular: uma manifestação rara de artrite reumatoide

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    Alexandre Wagner S. de Souza

    2013-08-01

    Full Text Available A vasculite testicular é uma manifestação extra-articular muito rara da artrite reumatoide (AR. Descrevemos o caso de um homem de 53 anos com diagnóstico de AR por oito anos, sem controle adequado da doença. O paciente desenvolveu vasculite reumatoide, manifestada por úlceras de membros inferiores e neuropatia periférica. Apresentou ainda meningite neutrofílica aguda, tendo sido tratado com antibióticos e posterior pulsoterapia endovenosa com metilprednisolona (500 mg/dia por três dias, seguida de ciclofosfamida (2 mg/kg/ dia e prednisona orais. O paciente apresentou melhora do quadro, mas 15 dias após a alta hospitalar, houve reativação da meningite bacteriana. O paciente foi reinternado e tratado novamente com antibióticos. Três dias depois da segunda admissão hospitalar, o paciente apresentou dor, aumento de volume do testículo esquerdo e posteriormente gangrena. Foi realizada orquiectomia unilateral e o exame anatomopatológico revelou vasculite linfocítica. O paciente faleceu dois dias após a cirurgia devido a pneumonia aspirativa. Esse caso ilustra a vasculite testicular como uma manifestação rara e grave da vasculite reumatoide.

  2. Post orchiectomy management in stage II testicular seminoma

    International Nuclear Information System (INIS)

    Twenty eight patients with stage II A and twenty patients with stage II B testicular seminoma were treated at this institute between January 1982 and December 1988. The three year crude survival observed in this retrospective analysis was 82% and 75% respectively. Post orchiectomy infradiaphragmatic radiotherapy was the mainstay of the treatment. In stage II A, 4 patients were administered adjuvant chemotherapy as well. Prophylactic mediastinal irradiation (PMI) was not employed as a routine in this subgroup. Eight patients (28%) relapsed (mediastinal nodes - 4, pulmonary - 3, scrotal - 1). In stage II B, twelve patients were treated with primary abdominal radiotherapy and of them 4 were delivered PMI as well. Induction chemotherapy was administered in remaining 8 patients. Seven patients (35%) relapsed (pulmonary-4, mediastinal nodes-3). Mediastinal recurrence was noted only in those who were treated with abdominal radiotherapy alone. Though salvage chemotherapy proved successful in 5 of the seven patients (70%) with nodal relapse, none of the patients with extranodal relapse responded to subsequent chemotherapy. For stage II A abdominal radiotherapy alone is recommended and for stage II B induction chemotherapy is advised keeping radiotherapy reserved for residual mass. PMI as a routine in stage II testicular seminoma is not advocated as no survival benefit is observed. (author) 15 refs., 6 tabs

  3. Dynamic MRI of benign and malignant testicular lesions: preliminary observations

    Energy Technology Data Exchange (ETDEWEB)

    Reinges, M.H.T. [Bonn Univ. (Germany). Radiologische Klinik]|[Neurochirurgische Klinik, RWTH Aachen (Germany); Kaiser, W.A. [Bonn Univ. (Germany). Radiologische Klinik]|[Institut fuer Diagnostische und Interventionelle Radiologie der Universitaet Jena, Bachstr. 18, D-07740 Jena (Germany); Miersch, W.D. [Bonn Univ. (Germany). Urologische Klinik; Vogel, J. [Bonn Univ. (Germany). Pathologisches Inst.; Reiser, M. [Bonn Univ. (Germany). Radiologische Klinik]|[Institut fuer Radiologische Diagnostik der Ludwig-Maximilians-Universitaet Muenchen, Klinikum Grosshadern, D-81366-Muenchen (Germany)

    1995-12-01

    Sonography and color-coded Doppler sonography are the methods of first choice in diagnosing pathological changes of the testes. The MRI technique was tested using a dynamic technique to evaluate the possibility of differentiating between benign and malignant testicular lesions. The testes of 20 volunteers and of 15 patients were examined in a field strength of 1.5 Tesla (Philips Gyroscan S 15) with a multislice T 1-weighted fast field echo (FFE) sequence before and every minute after the injection of 0.1 mmol/kg Gd-DTPA. The histopathological evaluation after the MRI examination revealed five seminomas, three mixed tumors, one teratocarcinoma, one embryonal carcinoma, one Sertoli tumor, two dermoid cysts, one chronic epididymitis/fibrosis and one necrosis/atrophy. In malignant lesions the maximum increase of signal intensity (SI) after injecting contrast medium was significantly higher (p < 0.001) compared with normal testes, whereas benign lesions showed a lower or similar maximum relative signal change compared with the volunteer group. If these early observations can be confirmed in a larger number of patients, dynamic MRI seems to be able to differentiate between benign and malignant testicular lesions. Dynamic MRI might become an additional tool with high diagnostic accuracy that is independent of the examiner. (orig.). With 14 figs., 2 tabs.

  4. Yolk sac tumor in a patient with transverse testicular ectopia

    Directory of Open Access Journals (Sweden)

    Zhu Yi-Ping

    2011-08-01

    Full Text Available Abstract Transverse testicular ectopia (TTE is a rare anomaly in which both testes descend through a single inguinal canal. We report a case of yolk sac tumor in the ectopic testis of a patient with TTE. A 24-year-old man presented to our hospital with a left inguinal-mass, right cryptorchidism and elevated alpha-fetoprotein (AFP. A left herniotomy 3 years earlier demonstrated both testes in the left scrotum, one above another positionally. Four months ago, a left scrotal mass appeared and radical orchiectomy of both testes revealed testicular yolk sac tumor of the ectopic testis. An enlarging left inguinal-mass appeared 2 months ago and he was referred to our hospital. Laboratory data showed an elevation of AFP (245.5 ng/ml and a 46 XY karyotype. He underwent bilateral retroperitoneal lymph node dissection and simultaneous left inguinal mass dissection. Histopathologic examination revealed a diagnosis of recurrent yolk sac tumor in the left inguinal mass. The retroperitoneal lymph node was not enlarged and, on histopathology, was not involved. The patient has now been followed up for 8 months without evidence of biochemical or radiological recurrence.

  5. Vanadium inhalation induces actin changes in mice testicular cells.

    Science.gov (United States)

    Rodríguez-Lara, Vianey; Morales-Rivero, Alonso; Rivera-Cambas, Angelica Muñiz; Fortoul, Teresa I

    2016-02-01

    Infertility is becoming a health problem, which has increased mainly in megacities, and several studies have shown its association with environmental pollution. Air pollution has been linked to alterations in sperm parameters, both in humans and animal models. In male humans, it has been associated with reduced semen quality and DNA alterations. Vanadium is a transition element that has increased in recent decades as a component of air suspended matter and has been associated with reprotoxic effects in animal models. Few are the mechanisms described by which the vanadium produces these effects, and cytoskeleton interaction is a possibility. We reported immunohistochemical changes in actin testicular cytoskeleton in a vanadium inhalation experimental mice model. Our findings show that exposure to vanadium pentoxide (0.02 M) results in actin decrease in testicular cells from 3-12 weeks exposure time; this effect was statistically significant and exposure time dependent. Actin cytoskeleton damage is a mechanism that could explain vanadium reprotoxic effects and its association with impaired fertility. PMID:24097359

  6. Is Radiotherapy Necessary for Stage 1 Testicular Seminoma?

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Ae; Park, Won; Lim, Do Hoon; Ahn, Yong Chan; Huh, Seung Jae; Yu, Jeong Il; Choi, Han Yong; Lee, Hyun Moo; Cho, Eun Yoon [Samsung Medical Center, Seoul (Korea, Republic of)

    2009-06-15

    To report on the clinical outcome of patients with stage I testicular seminoma by postoperative radiotherapy (PORT) or surveillance after radical inguinal orchiectomy. This study is a retrospective review of 32 stage I pure seminoma patients treated between 1996 and 2005 at the Samsung Medical Center. Twenty two of the patients were treated by PORT, which was directed at the paraaortic lymphatics with a median dose of 25.2 Gy in 14 fractions for 3 weeks. The 10 remaining patients were managed by surveillance. The median follow-up period was 96 months with a range of 24 to 155 months. Clinically, most patients presented with a testicular mass or discomfort. Two of the patients had a history of undescended testes. Pathologically, 23 of the patients had intratubular germ cell neoplasia with seminoma. Both recurrence-free survival (RFS) and overall survival (OS) rates of patients treated by PORT were 100%. In the control group, 1 of the 10 patients suffered a para-aortic lymph node relapse. The RFS and OS rates of the surveillance group were 88.9% and 100%, respectively. No difference in survival was observed between the two groups. Moreover, symptom recurrence was only observed in 1 patient in the control group. The use of PORT may reduce the risk of relapse. With the availability of effective diagnostic and salvage modalities, surveillance monitoring may be considered for patients in good compliance.

  7. Is Radiotherapy Necessary for Stage 1 Testicular Seminoma?

    International Nuclear Information System (INIS)

    To report on the clinical outcome of patients with stage I testicular seminoma by postoperative radiotherapy (PORT) or surveillance after radical inguinal orchiectomy. This study is a retrospective review of 32 stage I pure seminoma patients treated between 1996 and 2005 at the Samsung Medical Center. Twenty two of the patients were treated by PORT, which was directed at the paraaortic lymphatics with a median dose of 25.2 Gy in 14 fractions for 3 weeks. The 10 remaining patients were managed by surveillance. The median follow-up period was 96 months with a range of 24 to 155 months. Clinically, most patients presented with a testicular mass or discomfort. Two of the patients had a history of undescended testes. Pathologically, 23 of the patients had intratubular germ cell neoplasia with seminoma. Both recurrence-free survival (RFS) and overall survival (OS) rates of patients treated by PORT were 100%. In the control group, 1 of the 10 patients suffered a para-aortic lymph node relapse. The RFS and OS rates of the surveillance group were 88.9% and 100%, respectively. No difference in survival was observed between the two groups. Moreover, symptom recurrence was only observed in 1 patient in the control group. The use of PORT may reduce the risk of relapse. With the availability of effective diagnostic and salvage modalities, surveillance monitoring may be considered for patients in good compliance

  8. Individual variation related to testicular biometry and semen characteristics in collared peccaries (Tayassu Tajacu Linnaeus, 1758).

    Science.gov (United States)

    Peixoto, G C X; Silva, M A; Castelo, T S; Silva, A M; Bezerra, J A B; Souza, A L P; Oliveira, M F; Silva, A R

    2012-10-01

    The aim of this research was to study the individual variation with regard to the morphometry of the testes evaluated by ultrasonography and semen characteristics and to verify the existence of relationship between these variables in collared peccaries. In addition, the testes of the animals were evaluated by histology in order to determine the proportion occupied by the seminiferous tubules. A total of 52 ejaculates were obtained from ten adult specimens that had been restrained by anesthesia. The testicular measurements (length, height, and width) were performed by ultrasonography, and the testicular volume was calculated according to Lambert's formula. The scrotal circumference was measured by encircling the thickest portion of the testicle with a graduated nylon tape. The semen was collected by electroejaculation. Testicular fragments were analyzed through classic histology for the determination of the area occupied by the seminiferous tubules. The results show a great amount of individual variation with regard to testicular morphometry and semen characteristics. No significant correlations were obtained between testicular measurements and semen characteristics. The histometric analysis revealed that 67.8% of the testes are occupied by seminiferous tubules. Results show that the measurement of testicular dimensions does not serve as an indicator of the quality of semen obtained by electroejaculation in collared peccaries, as there is no correlation between testicular morphometry and semen characteristics in this species that presents large variations among individuals. PMID:22964034

  9. Chronic fluoride exposure-induced testicular toxicity is associated with inflammatory response in mice.

    Science.gov (United States)

    Wei, Ruifen; Luo, Guangying; Sun, Zilong; Wang, Shaolin; Wang, Jundong

    2016-06-01

    Previous studies have indicated that fluoride (F) can affect testicular toxicity in humans and rodents. However, the mechanism underlying F-induced testicular toxicity is not well understood. This study was conducted to evaluate the sperm quality, testicular histomorphology and inflammatory response in mice followed F exposure. Healthy male mice were randomly divided into four groups with sodium fluoride (NaF) at 0, 25, 50, 100 mg/L in the drinking water for 180 days. At the end of the exposure, significantly increased percentage of spermatozoa abnormality was found in mice exposed to 50 and 100 mg/L NaF. Disorganized spermatogenic cells, vacuoles in seminiferous tubules and loss and shedding of sperm cells were also observed in the NaF treated group. In addition, chronic F exposure increased testicular interleukin-17(IL-17), interleukin-17 receptor C (IL-17RC), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in transcriptional levels, as well as IL-17 and TNF-α levels in translational levels. Interestingly, we observed that F treated group elevated testicular inducible nitric oxide synthase (iNOS) mRNA level and nitric oxide (NO) concentration. Taken together, these results indicated that testicular inflammatory response could contribute to chronic F exposure induced testicular toxicity in mice. PMID:27031805

  10. Corporal and testicular biometry in wild boar from birth to 12 months of age

    Directory of Open Access Journals (Sweden)

    Danillo Velloso Ferreira Murta

    2013-02-01

    Full Text Available The aim of this tudy was to evaluate corporal and testicular development in wild boars (Sus scrofa scrofa from birth to 12 months of age, evaluating body weight, biometric testicular parameters, and gonadosomatic index. Thirty-nine male wild boars from a commercial farm licensed by IBAMA were used in the study. The animals were weighed and assigned to 13 experimental groups. The testes were recovered through unilateral orchiectomy, weighed on an analytical balance and measured for length, width and thickness. Body weight and testicular measures increased with the age, up to 12 months, and were more accelerated in the first and ninth months. Initially the testicular growth pattern, between zero and nine months, followed the body growth, and the gonadosomatic index varied from 0.07 to 0.09%. Between 9 and 11 months, the testicular growth was superior to the body growth, and the gonadosomatic index varied from 0.09 to 0.16%. Finally, after 11 months of age, testicular and body growth had a similar behavior. In conclusion, body weight, testicular biometry, and gonadosomatic index development accelerated in the ninth month.

  11. Leydig cell function in boys following treatment for testicular relapse of acute lymphoblastic leukemia

    International Nuclear Information System (INIS)

    Current practice for achieving local control of testicular relapse in males with acute lymphoblastic leukemia (ALL) includes the use of 2,400-rad testicular radiation. Although this therapy is known to cause germ cell depletion, it has been assumed that it does not alter testicular secretion of testosterone. To test this assumption, the authors measured gonadotropin and testosterone levels in seven boys with ALL who had been treated with radiation for clinically apparent testicular relapse. In four of seven boys, testicular relapse was bilateral with overt involvement of one testicle and microscopic involvement of the other. Three of these four boys demonstrated delayed sexual maturation, and in addition to elevated follicle-stimulating hormone (FSH) concentrations, testosterone levels were low and luteinizing hormone levels were elevated compared with controls. These data indicate that boys with overt testicular leukemia who are treated with 2,400-rad testicular radiation are at risk for Leydig cell dysfunction. However, the relative contributions of radiation, prior chemotherapy, and leukemic infiltration to this dysfunction remain to be clarified

  12. Association of veinous reflux with volume and hemodynamic parameters of testicular in patients with varicocele

    International Nuclear Information System (INIS)

    Objective: To study the affection of testicular volume, peak systolic velocity of intratesticular artery and resistance index in patients of varicocele associated with reflux by color Doppler ultrasound. Methods: One hundred and eight testiculars in 54 infertile patients were divided into 3 groups. There was the case of varicocele associated with reflux (Group A), varicocele not associated with reflux (Group B), and the case without varicocele (Group C). The size of testicular was measured accurately by two-dimensional ultrasound. Then the peak systolic velocity and the resistance index of intratesticular artery were measured by color Doppler ultrasound. The results were analyzed with statistical methods and comparison. Results: The average testicular volume in Group A was smaller, which was significantly different in testicular volume compared with that in Group B or Group C (P<0.01). There was no significant difference in testicular volume between Group B and Group C (P>0.05). There was no significant differences in peak systolic velocity of intratesticular artery and resistance index in each group (P>0.05). Conclusion: Varcocele with reflux can reduce the size of ipsilateral testicular volume, but can not affect the peak systolic velocity of intratesticular artery and resistance index. (authors)

  13. Applied anatomic study of testicular veins in adult cadavers and in human fetuses

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    Luciano A. Favorito

    2007-04-01

    Full Text Available OBJECTIVES: Analyze the anatomic variations of the testicular veins in human cadavers and fetuses. MATERIALS AND METHODS: One hundred male adult cadavers and 24 fetuses were studied. Four anatomic aspects were considered: 1 Number of testicular veins, 2 The local of vein termination, 3 Type and number of collaterals present and 4 Testicular vein termination angle. RESULTS: Cadavers - Right side - One testicular vein occurred in 85% and 2 veins in 5% of the cases. There were communicating veins with the colon in 21% of the cases. Left side - One testicular vein occurred in 82%, two veins in 15%, three veins in 2% and four veins in 1% of the cases. There were communicating veins with the colon in 31% of the cases. Fetuses - Right side -One testicular vein occurred in all cases. This vein drained to the vena cava in 83.3% of the cases, to the junction of the vena cava with the renal vein in 12.5% and to the renal vein in 4.2%. There were communicating veins with the colon in 25% of the cases. Left side - One testicular vein occurred in 66.6% of the cases, and 2 veins in occurred 33.3%. Communicating veins with the colon were found in 41.6% of the cases. CONCLUSION: The testicular vein presents numeric variations and also variations in its local of termination. In approximately 30% of the cases, there are collaterals that communicate the testicular vein with retroperitoneal veins. These anatomic findings can help understanding the origin of varicocele and its recurrence after surgical interventions.

  14. Epidermoid carcinomas of the anal canal treated with definitive radiation therapy in a series of 305 patients; Carcinomes epidermoides du canal anal traites par irradiation a visee curative: a propos de 305 patients

    Energy Technology Data Exchange (ETDEWEB)

    Deniaud-Alexandre, E.; Touboul, E.; Huang, R.; Qu, S.H.; Pene, F.; Schlienger, M. [Hopital Tenon, Service d' Oncologie-Radiotherapie, 75 - Paris (France); Tiret, E.; Parc, R. [Hopital Saint-Antoine, Service de Chirurgie Digestive, 75 - Paris (France); Sezeur, A. [Hopital des Diaconesses, Service de Chirurgie Generale, 75 - Paris (France); Houry, S. [Hopital Tenon AP-HP, Service de Chirurgie Digestive, 75 - Paris (France); Gallot, D. [Groupe Hospitalier Bichat-Claude-Bernard, Service de Chirurgie Generale et Digestive B, 75 - Paris (France)

    2003-08-01

    Purpose. - To identify prognostic factors and treatment toxicity in a series of epidermoid cancers of the anal canal without evident metastasis. Patients and methods. - Between June 1972 and January 1997, 305 patients (pts) were treated with curative-intent radiation therapy (RT). The T-stages according to the 1987 UICC classification were: 26 T1, 141 T2, 104 T3, and 34 T4. There were 49 pts with nodal involvement at presentation. Pretreatment anal function scoring according to our in-house system was: 22 scored 0, 182 scored 1, 74 scored 2, 7 scored 3. 11 scored 4, and 9 not available pts. The treatment started with external beam RT (EBRT) in 303 pts (median dose: 45 Gy). After a rest period of 4 to 6 weeks, a boost of 20 Gy was delivered by EBRT in 279 pts and by interstitial {sup 192}Ir brachytherapy (Bcy) in 17 pts. Seven pts received only one course of EBRT (mean dose: 49.5 Gy) and 2 pts were treated with interstitial {sup 192}Ir Bcy alone (55 and 60 Gy, respectively). concomitant chemotherapy (5-fluoro-uracil and either mitomycin C or cisplatin) was delivered to 19 pts. Mean follow-up was 103 months. Results. - At the end of RT local tumor clinical complete response (cCR) rate was 80%. Out of 61 non responders or local progressive tumors 27 (44%) were salvaged with abdomino-perineal resection (APR). The rate of local tumor relapse (LR) was 12%. Out of 37 LTR, 20 (54%) were salvaged with APR and one with interstitial {sup 192}Ir Bcy. The overall local tumor control (LC) rate with or without salvage local treatment was 84%. LC rate with a good anal function scoring (score 0 and 1) was 56.5%0. Among 181/186 available pts who preserved their anus, 94% had a good anal function scoring. For a subgroup of 15 pts with length tumor <2 cm-N0, the LC rate after the end of RT was 100% the LC rate with or without local salvage treatment was 100%, and among 13 available pts who preserved their anus, the anal function scoring was good in 12 pts (92%). The 10-years disease-free survival was 74%. After multivariate analysis, 3 independent predicting factors significantly influenced the disease-free survival: gap duration between 2 courses of RT (>38 days vs {<=}38 days, P=0.0025), pretreatment anal function scoring (0 vs 1 vs 2 vs 3 vs 4, P =4.4 10{sup -6}), and cCR after the end of RT (no complete response vs complete response, P =2.5 10{sup -14}). Conclusion. - We confirm excellent results with RT in T1 and T2 lesions. However, chemoradiotherapy should be preferred to improves survival free. of colostomy with a good anal sphincter function for tumors more than or equal to 2 cm in length and locally advanced tumors. (author)

  15. Percutaneous Revision of a Testicular Prosthesis is Safe, Cost-effective, and Provides Good Patient Satisfaction

    Directory of Open Access Journals (Sweden)

    Eugene B. Cone

    2015-09-01

    Full Text Available Office-based percutaneous revision of a testicular prosthesis has never been reported. A patient received a testicular prosthesis but was dissatisfied with the firmness of the implant. In an office setting, the prosthesis was inflated with additional fluid via a percutaneous approach. Evaluated outcomes included patient satisfaction, prosthesis size, recovery time, and cost savings. The patient was satisfied, with no infection, leak, or complication after more than 1 year of follow-up, at significantly less cost than revision surgery. Percutaneous adjustment of testicular prosthesis fill-volume can be safe, inexpensive, and result in good patient satisfaction.

  16. Percutaneous Revision of a Testicular Prosthesis is Safe, Cost-effective, and Provides Good Patient Satisfaction

    Science.gov (United States)

    Cone, Eugene B.; Lentz, Aaron C.

    2015-01-01

    Office-based percutaneous revision of a testicular prosthesis has never been reported. A patient received a testicular prosthesis but was dissatisfied with the firmness of the implant. In an office setting, the prosthesis was inflated with additional fluid via a percutaneous approach. Evaluated outcomes included patient satisfaction, prosthesis size, recovery time, and cost savings. The patient was satisfied, with no infection, leak, or complication after more than 1 year of follow-up, at significantly less cost than revision surgery. Percutaneous adjustment of testicular prosthesis fill-volume can be safe, inexpensive, and result in good patient satisfaction.

  17. Penis epidermoidal carcinoma

    International Nuclear Information System (INIS)

    It deals with a 58-years-old male, white man, with antecedents of blood hypertension, and increasing lesions in the penis since around 20 years ago, with changing locations. Two years ago it was diagnosed as acuminated condylomas, but it was not treated. The patient attended our hospital because twenty days ago the lesions adopted a tumor like aspect, and began to get abscessed, to ulcerate. The case was evaluated together with Dermatology and Urology. After some antibiotic treatments, it was obtained a biopsy of the lesion. The case is interesting because of the uncommon localization of the lesions in our patient and the increased level of the disease

  18. Carcinoma Epidermoide Primario de la Mama: Una Infrecuente Entidad Clínico-Patológica Primary Squamous Cell Carcinoma of the Breast: A Rare Clinicopathological Entity

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    Oscar Tapia E

    2011-09-01

    Full Text Available El carcinoma epidermoide (CE puro primario de la mama es una rara entidad clínico-patológica, que representa menos del 0,1% de todos los carcinomas de mama, conformada en su totalidad por células escamosas malignas que no presentan relación anatómica con la piel adyacente de la mama. Su etiopatogenia, pronóstico y tratamiento son motivo de controversias. Presentamos 1 caso de CE puros primario de la mama diagnosticado en la Unidad de Anatomía Patológica del Hospital Hernán Henríquez Aravena de la ciudad de Temuco, Chile.Pure primary squamous cell carcinoma (SCC of the breast is a rare clinicopathological entity, representing less than 0.1% of all breast carcinomas, composed entirely of malignant squamous cells do not exhibit anatomical relationship with the skin overlying to the breast. Its etiopathogenesis, prognosis and treatment is controversial. We present a case of pure primary SCC of the breast diagnosed at the Unit of Pathology, Hospital Hernán Henríquez Aravena.

  19. Feasibility of an early dynamic acquisition in PET-F.D.G. to evaluate the prognosis of epidermoid carcinomas of superior aero digestive pathways

    International Nuclear Information System (INIS)

    purpose: evaluate the feasibility of an early dynamic acquisition in PET-F.D.G. in the staging of squamous cell carcinomas of upper aero digestive tract. Extract kinetics parameters of F.D.G. tumor uptake and compare them to SUVmax at 60 minutes (prognosis value recognized but without established cut-off) and to ΔSUVmax (1-2 h). Conclusions: The results of our study demonstrates the realisation feasibility of a early 60 minutes dynamic acquisition in PET-F.D.G. at the cervical level, allowing to get a kinetic parameter (initial slope) independent of the SUVmax simple measure at 1 h and to envisage to compare their respective prognosis value in the initial evaluation of epidermoid carcinomas of superior aero digestive pathways. (N.C.)

  20. Intensity-modulated radiotherapy for epidermoid carcinoma of the anal canal: clinical results and assessment of acute toxicity and late toxicity

    International Nuclear Information System (INIS)

    As intensity-modulated conformational radiotherapy (IMRT) for epidermoid carcinomas of the anal canal presents a dosimetric advantage with respect to conventional radiotherapy, this study aims at highlighting the clinical impact of this advantage. About 70 patients have been treated by IMRT with a concomitant chemotherapy in case of locally advanced tumours. The authors indicate the dose delivered to the two different previsional target volumes (PTV), and discuss the clinical results obtained on the first 39 patients after two years in terms of acute and late toxicity. It appears that IMRT is well tolerated in terms of acute and late toxicity, allows a continuous treatment (without interruption) and dose escalation which could have an impact on clinical results on the long term. Short communication

  1. Testicular function and bone metabolism--beyond testosterone.

    Science.gov (United States)

    Ferlin, Alberto; Selice, Riccardo; Carraro, Umberto; Foresta, Carlo

    2013-09-01

    Findings in the past few years have advanced understanding of the crosstalk between testis and bone and could contribute to defining an improved clinical approach to the biochemical diagnosis and therapeutic management of hypogonadism and male osteoporosis. This Review focuses on the Leydig cells of the testis. Other than being responsible for steroidogenesis and production of testosterone, the function of these cells is fundamental to bone health in at least two other ways: Leydig cells produce insulin-like 3 (INSL3), which has a role in osteoblast function, and they contribute to 25-hydroxylation of vitamin D. Impairment of testicular function leads to low levels of testosterone, INSL3 and 25-hydroxyvitamin D and consequently to an increased risk of osteopenia and osteoporosis. PMID:23856820

  2. Testicular infarction secondary to protein S deficiency: a case report

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    Marron Conor

    2006-07-01

    Full Text Available Abstract Background Protein S deficiency is an inherited cause of thrombophilia. We present the second reported case in the literature of a man developing testicular infarction secondary to protein S deficiency. Case presentation A 63 year old man presented with sudden onset of pain in his left hemi-scrotum. Despite oral warfarin therapy the plasma INR was only 1.4 at presentation. Doppler ultrasound scan of the scrotum confirmed absent blood flow to the left testis with increased echogenicity. Orchidectomy was performed to remove the necrotic testis. Post-operatively the patient did well and was referred to the Regional Haemophilia and Thrombosis Centre for further management. Conclusion The case highlights a rare but potential complication of protein S deficiency and demonstrates the importance of adequate anticoagulation in these patients.

  3. Cytotoxic effects of WR-2721 on mouse testicular cells

    International Nuclear Information System (INIS)

    WR-2721 (S-2-(3-aminopropylamino)ethylphosphorothioic acid) has been demonstrated to be cytotoxic to stem spermatogonia in the mouse. Five and 10 injections of 300 mg/kg killed sufficient numbers of stem cells to reduce sperm production 56 days after treatment by 16 and 43%, respectively. Single injections of 300 or 400 mg/kg of WR-2721 given 15 min after irradiation produced negligible toxicity to stem cells as measured by counts of repopulated tubules; 600 mg/kg reduced stem cell survival by 47%. Four daily injections of 300 mg/kg given 4, 3, 2, and 1 days prior to irradiation reduced stem cell survival by about 60%. The cytotoxic effects of WR-2721 on testicular stem cells at least partially explains the reduced protection factors observed in the testis with low doses of radiation and during fractionated treatments involving multiple injections of drug

  4. Radionuclide ventriculography in testicular tumor patients following chemotherapy

    International Nuclear Information System (INIS)

    The toxicity was investigated of cytostatics with respect to the myocardium. Radionuclide ventriculography was used to monitor a group of 38 patients treated with cisplatin, adriamycin, vepeside, vinblastine and bleomycin for testicular carcinoma. The examination was performed prior to chemotherapy, in the course of chemotherapy and within two years after its termination. The global ejection fraction of the left ventricle, the diastolic and residual volumes, heart beat and the level of arrhythmia were examined. It was found that deviations from the normal condition appear from the start of therapy to two and more years after its termination and in a healthy heart may well be compensated. Radionuclide ventriculography may be recommended for patients prior to the start of chemotherapy. (M.D.). 7 figs

  5. Effect of zearalenone on expression of testicular genes in vivo

    Czech Academy of Sciences Publication Activity Database

    Žatecká, Eva; Děd, Lukáš; Dvořáková, Eva; Dorosh, Andriy; Elzeinová, Fatima; Pěknicová, Jana

    Praha : Biotechnologický ústav v. v. i. AV ČR, 2012 - (Pěknicová, J.). s. 44-44 [XVIII. symposium českých reprodukčních imunologů s mezinárodní účastí. 25.05.2012-26.05.2012, Žďár nad Sázavou] R&D Projects: GA ČR(CZ) GA523/09/1793; GA ČR(CZ) GAP503/12/1834 Institutional research plan: CEZ:AV0Z50520701 Keywords : zearalenone * testicular gene * gene expression * endocrine disruptor * PCR Subject RIV: DN - Health Impact of the Environment Quality

  6. Assessment of testicular metabolic integrity by P-31 MR spectroscopy

    International Nuclear Information System (INIS)

    The use of P-31 MR spectroscopy in the assessment of acute testicular ischemia and spermatogenesis was studied in canine and primate testicles, grouped as follows: group I(n = 8), in situ canine controls; group II(n = 11), canine testes subjected to warm ischemia (two were reperfused after 3 and 6 hours of ischemia); group III, canine (n = 4) and primate (n = 4) testicles from hormone-treated animals (intramuscular injections of estradiol and testosterone once weekly for 6 weeks). All testicles were studied histologically. Normal testes showed high monophosphate (MP) and adenosine triphosphate (ATP) levels and low inorganic phosphate (Pi), phosphodiester (PD), and phosphocreatinine (PCr) levels. Ischemic testes demonstrated a time-dependent decay of MP/Pi ratios (up to 30%). Regeneration of ATP was noted for up to 6 hours of ischemia. Group III testicles showed a significant decrease in MP and in MP/ATP ratios

  7. Testis-sparing surgery in the benign testicular tumors in boys

    International Nuclear Information System (INIS)

    Background. Testicular neoplasm in boys are rare. In despite of the adult testicular, neoplasm in children non-seminoma germ cell tumors are seen much more frequent, also in 30-70% of cases benign lesions exist and those tumors do not require chemo- and radiotherapy. Recently there is a great enthusiasm for testis sparing surgery. Objectives. Authors would like to present six boys with testicular mass operated with testis sparing surgery for benign tumors. Material and Methods. Between 1995 and 2004 in Department of Pediatric Surgery and Urology 33 boys were operated because of testicular malignances. In six cases in age from 1 to 17 years after histological (interoperation) confirmation of the benign origin of the tumor testis sparing surgery were performed. Results. In all six operated boys follow up is from 2 to 5 year and all are free from disease's symptoms. Ultrasound view of the operated testes are normal. (authors)

  8. Electronic Surveillance of Testicular Cancer: Understanding Patient Perspectives on Access to Electronic Medical Records

    OpenAIRE

    Groll, Ryan J.; Leonard, Kevin J.; Eakin, Joan; Warde, Padraig; Bender, Jackie; Jewett, Michael A. S.

    2009-01-01

    This study explores the basis for providing effective access to electronic medical record data as a reference source for patients with early-stage testicular cancer undergoing surveillance follow-up programs.

  9. Genomic and gene expression signature of the pre-invasive testicular carcinoma in situ

    DEFF Research Database (Denmark)

    Almstrup, Kristian; Ottesen, Anne Marie; Sonne, Si Brask; Hoei-Hansen, Christina E; Leffers, Henrik; Rajpert-De Meyts, Ewa; Skakkebaek, Niels E

    2005-01-01

    Testicular cancer is the most common malignancy among men in the reproductive age and the incidence is increasing, probably caused by environmental factors. Most testicular cancers are testicular germ cell tumours and all originate from a carcinoma in situ (CIS) pattern. In this review, we focus on...... the pre-invasive CIS and its possible fetal origin by reviewing recent data originating from DNA microarrays and comparative genomic hybridisations. A comparison of gene expression and genomic aberrations reveal chromosomal "hot spots" with mutual clustering of gene expression and genomic...... advantages in cultured undifferentiated embryonic stem cells after spontaneous amplification in similar regions. The gene expression profile of CIS cells has remarkable similarity to that of embryonic stem cells and supports our long-standing hypothesis of an early developmental origin of CIS and testicular...

  10. Cervical mature teratoma 17 years after initial treatment of testicular teratocarcinoma: report of a late relapse

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    Alavion Mina

    2007-01-01

    Full Text Available Abstract Background Late relapses of testicular germ cell tumor are uncommon. We report a case of cervical mature teratoma appeared 17 years after treatment of testicular teratocarcinoma. Case presentation A 20- year- old patient underwent left sided orchiectomy followed by systemic therapy and retroperitoneal residual mass resection in 1989. He remained in complete remission for 200 months. In 2005 a huge left supraclavicular neck mass with extension to anterior mediastinum appeared. Radical surgical resection of the mass was performed and pathologic examination revealed mature teratoma. Conclusion This is one of the longest long-term reported intervals of a mature teratoma after treatment of a testicular nonseminoma germ cell tumor. This case emphasizes the necessity for follow up of testicular cancer throughout the patient's life.

  11. Teaching Breast and Testicular Self-Exams: Evaluation of a High School Curriculum Pilot Project.

    Science.gov (United States)

    Luther, Stephen L.; And Others

    1985-01-01

    A high school curriculum project was developed to teach students about the importance of breast and testicular self-examination. Questionnaires were used to evaluate the project. Results are discussed. (DF)

  12. Testicular dysgenesis syndrome and the origin of carcinoma in situ testis

    DEFF Research Database (Denmark)

    Sonne, Si Brask; Kristensen, David Møbjerg; Novotny, Guy W; Olesen, Inge Ahlmann; Nielsen, John E; Skakkebaek, Niels E; Rajpert-De Meyts, Ewa; Leffers, Henrik

    2008-01-01

    Recent increases in male reproductive disorders have been linked to exposure to environmental factors leading to the testicular dysgenesis syndrome (TDS). Testicular cancer is the most severe condition in TDS and studies have shown a clear correlation between risk of testicular cancer and other...... components of TDS and that the geographical location of the mother during pregnancy can be a risk factor. This suggests that the dysgenesis has its origin in utero and that TDS is initiated by environmental factors, including possibly hormone-disrupting compounds that act on the mother and the developing...... foetus, but the genetic background may also play a role. The morphological similarity of carcinoma in situ (CIS) cells (the precursor of the majority of invasive testicular cancers) with primordial germ cells and gonocytes, and overlap in expression of protein markers suggests an origin of CIS from...

  13. Relationship between testicular sperm extraction results and AZF gene mutations

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    Raşit Altıntaş

    2011-09-01

    Full Text Available Objective: In this study, the effects of testicular sperm extraction (TESE outcome on Y microdeletion, caryotype analysis, and pathology results in azoospermic infertile male patients were investigated.Materials and methods: A total of 165 azoospermic infertile male patients who underwent TESE between January 2008-December 2009 in Ege University Faculty of Medicine, Urology Department have been evaluated for medical history, physical examination, spermiogram, caryotype analysis, Y chromosome microdeletion, FSH level, and TESE outcome regarding sperm availability.Results: Mean age of patients was 34±5.42 years, mean time of infertility was 73±57.7 months, and infertility type was primary in 98.8% of cases. Mean testicular volume was 12.3 cc, and varicocele was detected in 32 patients. Mean FSH level was 17 IU/mL. In 10 of the cases AZFc deletion, in 1 case AZFb deletion and in 1 case both deletions were identified. Number of patients underwent microTESE and conventional TESE were 109 and 56, respectively. Regarding the pathological outcomes, 91 (55.2% cases were germinal cell aplasia, 32 (19.4% cases were maturation arrest, 23 (13.9% cases were normal spermatogenesis, 10 (6.1% cases were tubulary sclerosis, 9 (5.5% cases were hipospermatogenesis. The cases in which Y microdeletion was present, pathological outcome was 75% germinal cell aplasia and 25% maturation arrest. Sperm avaliability was present in 37.5% of all cases, and this ratio was 27.2% in the cases with AZFc mutation.Conclusion: TESE operation is a method that can be applied successfully in the treatment of azospermia. Detection of the AZF gene mutations is useful to predict a negative TESE outcome.

  14. Endogenous DNA Damage and Risk of Testicular Germ Cell Tumors

    Energy Technology Data Exchange (ETDEWEB)

    Cook, M B; Sigurdson, A J; Jones, I M; Thomas, C B; Graubard, B I; Korde, L; Greene, M H; McGlynn, K A

    2008-01-18

    Testicular germ cell tumors (TGCT) are comprised of two histologic groups, seminomas and nonseminomas. We postulated that the possible divergent pathogeneses of these histologies may be partially explained by variable endogenous DNA damage. To assess our hypothesis, we conducted a case-case analysis of seminomas and nonseminomas using the alkaline comet assay to quantify single-strand DNA breaks and alkali-labile sites. The Familial Testicular Cancer study and the U.S. Radiologic Technologists cohort provided 112 TGCT cases (51 seminomas & 61 nonseminomas). A lymphoblastoid cell line was cultured for each patient and the alkaline comet assay was used to determine four parameters: tail DNA, tail length, comet distributed moment (CDM) and Olive tail moment (OTM). Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using logistic regression. Values for tail length, tail DNA, CDM and OTM were modeled as categorical variables using the 50th and 75th percentiles of the seminoma group. Tail DNA was significantly associated with nonseminoma compared to seminoma (OR{sub 50th percentile} = 3.31, 95%CI: 1.00, 10.98; OR{sub 75th percentile} = 3.71, 95%CI: 1.04, 13.20; p for trend=0.039). OTM exhibited similar, albeit statistically non-significant, risk estimates (OR{sub 50th percentile} = 2.27, 95%CI: 0.75, 6.87; OR{sub 75th percentile} = 2.40, 95%CI: 0.75, 7.71; p for trend=0.12) whereas tail length and CDM showed no association. In conclusion, the results for tail DNA and OTM indicate that endogenous DNA damage levels are higher in patients who develop nonseminoma compared with seminoma. This may partly explain the more aggressive biology and younger age-of-onset of this histologic subgroup compared with the relatively less aggressive, later-onset seminoma.

  15. Structural analysis of testicular appendices in patients with cryptorchidism

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    Guilherme D. Tostes

    2013-04-01

    Full Text Available Objectives Report the incidence and structure of testicular appendices (TAs in patients with cryptorchidism, comparing their incidence with epididymal anomalies (EA and patency of the vaginal process (PVP and analyzes the structure of TAs. Material and Methods We studied 72 testes of patients with cryptorchidism (average of 6 years, and 8 testes from patients with hydroceles (average of 9 years. We analyzed the relations among the testis, epididymis and PVP and prevalence and histology of the TAs. The appendices of 10 patients with cryptorchidism and 8 with hydrocele were dissected and embedded in paraffin and stained with Masson trichrome; Weigert and Picro-Sirius Red with polarization and immunohistochemistry analysis of the collagen type III fibers to observe collagen. The stereological analysis was done with the software Image Pro and Image J, using a grid to determine volumetric densities (Vv. Means were statistically compared using the ANOVA and unpaired T test (p < 0.05. Results Of the 72 testes with cryptorchidism, 20 (27.77% presented EA, 41 (56.9% had PVP and 44 (61.1% had TAs. Of the 44 testes with cryptorchidism and appendices, 30 (68.18% presented PVP and 11 (25% presented EA. There was no alteration of the epithelium in the appendices of patients in both groups. Stereological analysis documented the prevalence of ESFs (mean of 1.48%, prevalence of veins (mean of 10.11% and decrease (p = 0.14 of SMCs in the TAs of patients with cryptorchidism (mean = 4.93%. Collagen III prevailed in the TAs of patients with cryptorchidism. Conclusion The testicular appendices presented significant structural alteration in the patients with cryptorchidism, indicating that TAs present a structural remodeling.

  16. Tumor canceroso testicular: Seminoma clásico

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    Campuzano J. Sandra

    2011-06-01

    Full Text Available El tumor canceroso tipo seminoma es el cáncer testicular más frecuente, afecta con mayor frecuencia a las personasde una edad media de 50 años. El seminoma presenta factores de riesgo como criptorquidia, infertilidad y antecedentes familiares de primer grado con cáncer. La estadificación determina la extensión de la invasión hacia órganos vecinos; TNM (Tumor, Nódulo, Metástasis. El diagnóstico se realiza por la clínica, se observa una masa crecientede gran volumen, pero también se usa Marcadores Tumorales; como la Alfa feto proteína, la cual es negativa siempre para seminoma y B Gonadotrofina Coriónica Humana, la cual con muy poca frecuencia está elevada. Entre los métodos de imagen que se usan están la Radiografía de tórax, Tomografía de abdomen y pelvis para descartar metástasis. Se presenta un caso de un paciente de 52 años de edad, con una masa voluminosa testicular- indolora, de unos 7 años de evolución que desde hace 2 meses presenta puntos de hemorragia externa. Al examen físico presenta una masa de 18 por 15 cm, con un punto de hemorragia en la región escrotal y secreción purulenta en el prepucio, posteriormente se procede al tratamiento adecuado.

  17. Impact of Bep or Carboplatin Chemotherapy on Testicular Function and Sperm Nucleus of Subjects with Testicular Germ Cell Tumor

    Science.gov (United States)

    Ghezzi, Marco; Berretta, Massimiliano; Bottacin, Alberto; Palego, Pierfrancesco; Sartini, Barbara; Cosci, Ilaria; Finos, Livio; Selice, Riccardo; Foresta, Carlo; Garolla, Andrea

    2016-01-01

    Young males have testicular germ cells tumors (TGCT) as the most common malignancy and its incidence is increasing in several countries. Besides unilateral orchiectomy (UO), the treatment of TGCT may include surveillance, radiotherapy, or chemotherapy (CT), basing on tumor histology and stage of disease. It is well known that both radio and CT may have negative effects on testicular function, affecting spermatogenesis, and sex hormones. Many reports investigated these aspects in patients treated with bleomycin, etoposide, and cisplatin (BEP), after UO. In contrast no data are available on the side effects of carboplatin treatment in these patients. We included in this study 212 consecutive subjects who undergone to sperm banking at our Andrology and Human Reproduction Unit after UO for TGCT. Hundred subjects were further treated with one or more BEP cycles (BEP-group), 54 with carboplatin (CARB group), and 58 were just surveilled (S-group). All patients were evaluated for seminal parameters, sperm aneuploidy, sperm DNA, sex hormones, volume of the residual testis at baseline (T0) and after 12 (T1) and 24 months (T2) from UO or end of CT. Seminal parameters, sperm aneuploidies, DNA status, gonadic hormones, and testicular volume at baseline were not different between groups. At T1, we observed a significant reduction of sperm concentration and sperm count in the BEP group versus baseline and versus both Carb and S-group. A significant increase of sperm aneuploidies was present at T1 in the BEP group. Similarly, the same group at 1 had altered sperm DNA integrity and fragmentation compared with baseline, S-group and Carb group. These alterations were persistent after 2 years from the end of BEP treatment. Despite a slight improvement at T2, the BEP group had still higher percentages of sperm aneuploidies than other groups. No impairment of sperm aneuploidies and DNA status were observed in the Carb group both after 1 and 2 years from the end of treatment. Despite preliminary, these data demonstrate that in selected patients with TGCTs CT with carboplatin represents a therapeutic option that that seems to not affect sex hormones, spermatogenesis, and sperm nucleus.

  18. Paradoxical sleep deprivation changes testicular malondialdehyde and caspase-3 expression in male rats

    OpenAIRE

    Fitranto Arjadi; Ginus Partadireja; Lientje Setyawan Maurits; Mulyono Pangestu

    2015-01-01

    BACKGROUND Sleep deprivation is a significant problem among adult men and is considered as a risk factor for several diseases. Paradoxical sleep deprivation (PSD) induces Leydig cell apoptosis through elevation of corticosterone, with testicular malondialdehyde (MDA) and Leydig cell caspase-3 expression as parameters. The aim of this study was to observe testicular MDA level and caspase-3 expression treated with paradoxical sleep deprivation (PSD), immobilization, and foo...

  19. Paradoxical sleep deprivation changes testicular malondialdehyde and caspase-3 expression in male rats

    OpenAIRE

    Fitranto Arjadi; Ginus Partadireja; Lientje Setyawan Maurits; Mulyono Pangestu

    2015-01-01

    BACKGROUND Sleep deprivation is a significant problem among adult men and is considered as a risk factor for several diseases. Paradoxical sleep deprivation (PSD) induces Leydig cell apoptosis through elevation of corticosterone, with testicular malondialdehyde (MDA) and Leydig cell caspase-3 expression as parameters. The aim of this study was to observe testicular MDA level and caspase-3 expression treated with paradoxical sleep deprivation (PSD), immobilization, and footshock stress and ...

  20. Cytogenetic Follow-Up in Testicular Seminoma Patients Exposed to Adjuvant Radiotherapy

    OpenAIRE

    Gamulin, Marija; Kopjar, Nevenka; Grgić, Mislav; Ramić, Snježana; Viculin, Tomislav; Petković, Marija; Garaj-Vrhovac, Verica

    2010-01-01

    Early stage testicular seminoma is a radiosensitive tumor. Its incidence has significantly increased during the last decade especially in the young population. Although the therapy for testicular seminoma gives very satisfying results, the evaluation of genome damage caused by the therapy is of a great importance in order to recognize possible related health risks. The present study was performed on ten patients diagnosed with seminoma stage I; pT1/2N0M0S0, treated with adjuvant radiotherapy ...