UK PubMed Central (United Kingdom)

Motivation: Automatic recognition of cell identities is critical for quantitative measurement, targeting and manipulation of cells of model animals at single-cell resolution. It has been...Full Text Available

Science.gov (United States)

... power from wood and bagasse as well as convert non-traditional fuel sources such as rice bulls, animal manure, cotton gin trash, straws, and ...

Energy Technology Data Exchange (ETDEWEB)

2,6-Dinitrotoluene (2,6-DNT) and pentachlorophenol (PCP) are used for industrial purposes and are found in the environment as hazardous contaminants. Because concurrent exposure to both compounds can occur, it is of interest to determine if organochlorine compounds potentiate the effect of nitroaromatic chemicals. A significant increase in mutagenicity was observed in urines from mice treated with 2,6-DNT alone and in combination with PCP. By week 4, mice that received both 2,6-DNT and PCP excreted urine that was more mutagenic than that from animals which received only 2,6-DNT. At weeks 2 and 4, mice were sacrificed and intestinal enzyme activities (nitroreductase, azo reductase, {beta}-glucuronidase, dechlorinase, and dehydrochlorinase) were quantitated. The enhanced genotoxicity observed in urines from 2,6-DNT/PCP-treated mice coincided with a decrease in nitroreductase and an increase in {beta}-glucuronidase activities in the ...

Science.gov (United States)

... 15- Two Sigma from Mean S..... I ..... 2 ... only a small number of engine filter debris samples ... comprehensive, but it does point out that ...

UK PubMed Central (United Kingdom)

BackgroundAnimals carrying genetic mutations have provided powerful insights into the role of interstitial cells of Cajal (ICC) in motility. One classic model is...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

The Pacific white shrimp, Litopenaeus vannamei, is the most important shrimp species in volume in world aquaculture. However, in recent decades, outbreaks of diseases, especially viral diseases, have led to significant economic losses, threatening the sustainability of shrimp farming worldwide. In 2004, Brazilian shrimp farming was seriously affected by a new disease caused by the Infectious myonecrosis virus (IMNV). Thus, disease control based on rapid and sensitive pathogen detection methods has become a priority. In this study, a specific quantitation method for IMNV was developed using real-time PCR with SYBR Green chemistry and viral load of the principal target tissues of chronically infected animals was quantified. The quantitative analysis revealed that mean viral load ranged from ...

Transactions and Proceedings of the Royal Society of New Zealand 1868-1961

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British Library Electronic Table of Contents (United Kingdom)

Mechanobiological theories have been introduced to illustrate the interaction between biology and the local mechanical environment during bone healing. Although several theories have been proposed, a quantitative validation using histomorphometric data is still missing. In this study, in vivo histological data based on an ovine animal experiment was quantified and used to validate bone healing simulations focussing on the endochondral ossification process. The bone formation at different callus regions (periosteal and endosteal bone at the medial and lateral side) was analyzed from in vivo data and quantitatively compared with in silico results. A histomorphometric difference was found in medial and lateral hard callus formation 3 weeks after osteotomy. However, the same amount of new bone...

International Nuclear Information System (INIS)

A brain weight deficit of about 70 mg was induced at doses of approximately 75-mGy and a deficit of 60 mg was induced at 100 mGy. This confirms the effects projected and observed by Wanner and Edwards. Although the data do not demonstrate a clear dose-response relationship between the 75-mGy and 100-mGy groups, the data are statistically consistent with a dose-response effect because of the overlapping confidence intervals. The lack of a statistically significant observation is most likely related to the small difference in doses and the limited numbers of animals examined. There are several factors that can influence the brain weight of guinea pig pups, such as caging and housing conditions, the sex of the animal, and litter size. These should be taken into account for accurate analysis. Dam weight did not appear to have a significant effect. The confirmation of a micrencephalic effect induced x rays at doses of 75-mGy ...

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In this work was made an assessment of the supramolecular structures presents into human breast tissue normal and pathological samples, as well as into two types of animals samples (tendon chicken and pork fat) using the small angle x-ray scattering (SAXS) technique. The scattering profiles of the samples were determined at the momentum transfer range O.150nm{sup -1}<=5:q(=4pi.sin({theta}/2)/{lambda})<=8.500nm{sup -1}. In this range, it was possible identify structures corresponding to collagen fibrils (glandular tissue) and to triacylglycerides (adipose tissue) from the correlation between the information extracted from the human breast tissues scattering profiles and those extracted from animals samples. (author)

International Nuclear Information System (INIS)

Medical imaging using single gamma-ray-emitting radionuclides typically makes use of parallel hole collimators or pinholes in order to achieve good spatial resolution. However, a tradeoff in sensitivity is inherent in the use of a collimator, and modern preclinical single photon emission computed tomography (SPECT) systems detect a very small fraction of emitted gamma rays, often less than 0.1%. A system for small animal SPECT imaging which uses no collimators could potentially achieve very high sensitivity-several tens of percent-with reasonably sized detectors. This would allow two significant improvements in preclinical studies: images could be obtained more rapidly, allowing higher throughput for screening applications, or for dynamic processes to be observed with very good time resolution; and images could be obtained with less radioactive tracer, making possible the in vivo imaging of low-capacity receptor systems, ...

Science.gov (United States)

Spectrophotometric method, using a ratio-recording ultraviolet-absorption spectrophotometer, permits analysis of NaMBT in ethylene glycol-water solutions with high accuracy. It reduces analysis time, requires smaller samples, and is able to detect extremely small concentrations of mercaptobenzothiazole.

British Library Electronic Table of Contents (United Kingdom)

Proteins with a high propensity to aggregate can be largely prevented from doing so with surprisingly small changes to their primary structure. By using a combination of rational design and quantitative measurements of aggregation rates, we show that adding a single charge in specific "gatekeeper" regions is sufficient to change the timescale for amyloid fibril growth from minutes to weeks, thereby dramatically reducing the efficiency of this process.

Science.gov (United States)

Local cardiac glucose utilization (LCarGU) was quantified in the rat heart according to the Sokoloff model and local cardiac blood flow (LCarBF) according to the /sup 14/C-iodoantipyrine method. For quantitative autoradiography calibration curves for heart slices were performed. They differed from the brain calibration curves by 8%. The lumped constant was 0.377 in isolated working hearts. LCarGU and LCarBF could then be quantified in awake rats. At different locations mean LCarGU of different hearts varied from 85 to 200 ..mu..moles/100g/min and mean LCarBF from 390 to 831 ml/100g/min. The ratio subendocardial/subepicardial glucose utilization or blood flow was not systematically different from 1. The results indicate that glucose can be an important fuel in the heart of the awake rat, although its contribution to overall metabolism varies from animal to animal.

British Library Electronic Table of Contents (United Kingdom)

Background Identifying susceptibility genes for endophenotypes by studying analogous behaviors across species is an important strategy for understanding the pathophysiology underlying psychiatric disorders. This approach provides novel biological pathways plus validated animal models critical for selective drug development. One such endophenotype is avoidance behavior. Methods In the present study, novel automated registration methods for longitudinal behavioral assessment in home cages are used to screen a panel of recently generated mouse chromosome substitution strains that are very powerful in quantitative trait loci (QTL) detection of complex traits. In this way, we identified chromosomes regulating avoidance behavior (increased sheltering preference) independent of motor activity lev...

International Nuclear Information System (INIS)

The activity of tyrosine aminotransferase (TAT) in the liver of mice subjected simultaneously to ionizing radiation and to local inflammatory process showed in the first 24 hours of the experiment statistically significant changes resulting from summation of the harmful effects of both factors. In the second 24-hour period an evident tendency was observed for return of a normal circadian rhythm of the enzyme. This points to presence of an endogenous mechanism of suppression of the manifestations of significant desynchronization of the circadian rhythm. The paper contains also a trial of mathematical analysis of changes in TAT activity in the circadian rhythm, a description and analysis or the suppression process, qualitative and quantitative determination of the phenomenon of cumulation of the effects of powerful stress factors acting on the animal organism. The obtained results were compared with the results of investigations of TAT activity ...

International Nuclear Information System (INIS)

Objectives: To minimize movement artifacts during tracer imaging studies, the animals are generally sedated. Although many reports describe the effect of barbiturates on brain function, less is published about the general impact on the extracerebral metabolism and tracer biodistribution. This report describes the influence of pentobarbital on tumor uptake of ["1"2"3I]-2-iodo-L-phenylalanine (["1"2"3I]-2I-L-PA) using dissection and nuclear imaging. Methods: R1M tumor-bearing athymic mice were divided into two populations: untreated and pentobarbital-treated. Each group was subjected to dynamic and static planar imaging and organ dissection after ["1"2"3I]-2I-L-PA injection. Two-compartment blood modeling was performed. Analysis of variance (ANOVA), t test and clustered boxplot analyses were used to compare the results between the treatment groups and between the data acquisition methods. Results: Two-compartment blood modeling demonstrated that pentobarbital ...

International Nuclear Information System (INIS)

Abstract only.

Energy Technology Data Exchange (ETDEWEB)

The NA50 Collaboration has recently observed a strong suppression of {ital J}/{psi} production in Pb-Pb collisions at 158GeV/nucleon. We show that this recent observation finds a quantitative explanation in a model which relates the suppression mechanism to the local energy density, whose value is higher in Pb-Pb collisions than in any other system studied previously. The sensitivity of the phenomenon to small changes in the energy density could be suggestive of quark-gluon plasma formation. {copyright} {ital 1996 The American Physical Society.}

Energy Technology Data Exchange (ETDEWEB)

This paper analyses the errors caused by interpolation from existing cases for assessing indoor air flow, air quality and thermal comfort in an office. A sensitivity study is then provided to determine the influence of several boundary conditions on indoor air diffusion. The research is conducted numerically by using a low-Reynolds-number k-{epsilon} model. It can be concluded that the interpolation errors caused by the variations of solar radiation, window size, heat source location due to lighting, and the surface temperatures of interior walls are small and can be quantitatively determined. But it is difficult to estimate the errors introduced by the variations of furniture location and size. (author).

International Nuclear Information System (INIS)

Quantitative, experimentally based assessments of the biases of the methods used to develop the neutronics design of the FTR are presented together with brief descriptions of the design methods. Uncertainties in biases have been established that are sufficiently small to allow a high degree of confidence in the nuclear design. Experimental data for these assessments have been developed in full-scale zero-power mockups of the final design of the reactor, except for Doppler data from SEFOR. Temperature, power coefficient, and stability methods evaluations are necessarily deferred to acceptance testing during initial startup of the FTR. Sodium voiding and small sample worths continue to be the technical areas of greatest complexity with least experiment-theory correlation. Critical mass, Doppler effects, control rod worth, and spatial power distribution have generally good experiment-theory correlations.

International Nuclear Information System (INIS)

Planktivores, zooplankton grazers, and macrobenthos were studied to determine how changes in animal community structure may alter the flow of material in Dunham Pond, CT. Chaoborus and chironomid larvae were studied to determine how they affect the flux of matter across the sediment/water interface. This was done by incubating undisturbed cores in situ and relating changes in water chemistry to larval density. The log-transformed flux rates of iron, manganese, and phosphorus were linearly related to larval biomass. Functional groups may be successfully used to predict rates of material flow. Changes in the mass of macroinvertebrates affect the flux rates of redox-active substances across the sediment/water interface. The use of population densities and feeding characteristics to estimate trophic transfer in Dunham Pond indicate that (1) visual planktivory by larval perch may result in overutilization of prey, (2) ambush planktivory by univoltine Chaoborus appears ...

British Library Electronic Table of Contents (United Kingdom)

Introduction.Microfluidic technology allows fast reactions in a simple experimental setup, while using very low volumes and amounts of starting material. Consequently, microfluidic technology is an ideal tool for radiolabeling reactions involving short-lived positron emitters. Optimization of the complex array of different reaction conditions requires knowledge of the different reaction parameters linked to the microfluidic system as well as their influence on the radiochemical yields. 1-(5-Deoxy-5-fluoro-?-d-arabinofuranosyl)-2-nitroimidazole ([18F]FAZA) is a frequently used radiotracer for PET imaging of tumor hypoxia. The present study describes the radiosynthesis of [18F]FAZA by means of microfluidic technology and subsequent small animal PET imaging in EMT-6 tumor-bearing mice.Methods...

Environmental Research Database

Objectives1. We will use reduction of lysosomal stability as an indicator of cell injury induced by C-60 fullerenes and carbon nanotubes in the liver analogue or digestive gland (hepatopancreas) of marine mussels. Molluscan hepatopancreatic digestive cells are key to normal function and are a sensitive key interface with the environment. Reduction of lysosomal stability is mechanistically linked with impaired health of the whole animal. 2. We will also test the hepatopancreatic digestive cells for evide [continued...]DescriptionNanotechnology is a major innovative scientific and economic growth area, which may present a variety of hazards for environmental and human health. The surface properties and very small size of nanoparticles and nanotubes provides surfaces that may bind and transport toxic chemical pollutants, as well as possibly being toxic in their own right by generating reactive oxygen species (ROS). There is a wealth of evidence ...

Science.gov (United States)

Skin sensitization is the most commonly reported occupational illness, causing much suffering to a wide range of people. Identification and labeling of environmental allergens is urgently required to protect people from skin sensitization. The guinea pig maximization test (GPMT) and murine local lymph node assay (LLNA) are the two most important in vivo models for identification of skin sensitizers. In order to reduce the number of animal tests, quantitative structure-activity relationships (QSARs) are strongly encouraged in the assessment of skin sensitization of chemicals. This paper has investigated the skin sensitization potential of 162 compounds with LLNA results and 92 compounds with GPMT results using a support vector machine. A particle swarm optimization algorithm was implemented for feature selection from a large number of molecular descriptors calculated by Dragon. For the LLNA data set, the classification accuracies are 95.37% and ...

International Nuclear Information System (INIS)

The purpose of this study was to investigate the feasibility of a simple deformable phantom as a QA tool for testing and validation of deformable image registration algorithms. A diagnostic thoracic imaging phantom with a deformable foam insert was used in this study. Small plastic markers were distributed through the foam to create a lattice with a measurable deformation as the ground truth data for all comparisons. The foam was compressed in the superior-inferior direction using a one-dimensional drive stage pushing a flat 'diaphragm' to create deformations similar to those from inhale and exhale states. Images were acquired at different compressions of the foam and the location of every marker was manually identified on each image volume to establish a known deformation field with a known accuracy. The markers were removed digitally from corresponding images prior to registration. Different image registration algorithms were tested using this method. Repeat ...

International Nuclear Information System (INIS)

A new microdensitometry method for quantitative assessment of bone mineral content using Fuji computed radiography (FCR) was developed and the results were compared with those obtained by the conventional film-screen method. Using both methods, X-ray pictures of the 2nd metacarpal bone were taken with a reference aluminum step wedge in nine normal subjects and nine parameters representing the width and density of bone marrow and cortex were calculated in middle of the bone shaft. Interobserver reproducibility assessed for three parameters was significantly higher in the FCR method than the conventional one. The value of #SIGMA#GS computed by the FCR method, that is equivalent to the net bone density of the transverse section of the shaft, showed higher correlation with the one obtained by computed tomography in comparison with the conventional method. In our FCR method, moreover, interobserver reproducibility and accuracy was improved by employing automatic ...

Energy Technology Data Exchange (ETDEWEB)

Microstructural evolution due to thermal effects was studied in micro solder joints (55 {+-} 5 {micro}m). The composition of the Sn/Pb solder studied was found to be hypereutectic with a tin content of 65--70 wt%.This was determined by Energy Dispersive X-ray analysis and confirmed with quantitative stereology. The quantitative stereological value of the surface-to-volume ratio was used to characterize and compare the coarsening during thermal cycling from 0--160 C to the coarsening during annealing at 160 C. The initial coarsening of the annealed samples was more rapid than the cycled samples, but tapered off as time to the one-half as expected. Because the substrates to which the solder was bonded have different thermal expansion coefficients, the cycled samples experienced a mechanical strain with thermal cycling. The low-strain cycled samples had a 2.8% strain imposed on the solder and failed by 1,000 cycles, despite undergoing less ...

International Nuclear Information System (INIS)

Modern digital radiographic 'flat panel' detectors can exhibit a progressive form of image degradation arising from non-functioning pixels. The effect of these 'dead pixels' on the quantitative image quality measures of modulation transfer function (MTF), noise power spectrum (NPS) and detective quantum efficiency (DQE) is investigated by a simulated degradation of images obtained from an Hologic EPEX system. The effects on the semi-quantitive measures obtained from contrast threshold test objects and resolution gratings are also investigated. Results suggest that the contrast-detail tests often employed in quality assurance measures are not sufficient to reveal the presence of dead pixels until well beyond the recommended replacement point for the flat panel detector. However, measurements of spatial resolution using a line pairs phantom were found to be more sensitive to pixel loss. Measurement of the MTF, NPS and DQE can reveal ...

Energy Technology Data Exchange (ETDEWEB)

To assess the technical feasibility of a newly designed stent-like electrode in rabbits. A stent-like electrode was knitted from a single thread of nitinol wire and interconnected to a generator using similar wire. In order to gauge the extent of radiofrequency ablation (RFA), we measured the depth of the ablated area in cow liver using a combination of 180-sec time intervals and 20- watt power increments. For data processing, Cox regression analysis was used. RFA was also applied to the small intestine of rabbits using this stent-like electrode under six different sets of conditions: 10 watts for 1 min, 10 watts for 2 mins, 20 watts for 1 min, 20 watts for 2 mins, 30 watts for 1 min, and 30 watts for 2 mins. To determine the gross and microscopic findings, six animals were sacrificed immediately after the procedure and the results obtained under the different sets of conditions were correlated. Eight rabbits were monitored for 4 weeks prior to ...

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The mechanisms of brown adipocyte proliferation and differentiation during cold acclimation (and/or adaptation to hyperphagia) have been studied by quantitative photonic radioautography. (/sup 3/H)thymidine was injected to warm-acclimated (25/sup 0/C) rats and to animals exposed to 5/sup 0/C for 2 days. Samples of interscapular brown adipose tissue were collected for quantitative analysis of mitotic frequencies at various periods of time (4 h-15 days) after the injection of (/sup 3/H)thymidine, the rats being maintained at the temperatures to which they were initially exposed. It was found that cold exposure for 2 days markedly enhanced mitotic activity in endothelial cells, interstitial cells, and brown preadipocytes rather than in fully differentiated brown adipocytes. The total tissue labeling index (percent of labeled nuclei) increased approx.70 times over control values. The authors now report that cellular labeling ...

International Nuclear Information System (INIS)

An attempt was made for early quantitative assessment of the severety of an injury, using the nuclear acids (NA) content as a biochemical indicator. Sexually mature male rats with body mass 160-180 g were irradiated with doses 0.5, 1, 2, 4 and 8 Gy of "1"3"7Cs source. Uneven irradiation was achieved by shielding the abdominal-lumbar area with lead rings, measuring 2,5/50 mm. A 28-30% fall of the dose beneath the shielded zone was thus provided. Dose-dependent quantitative changes in Na content were determined on hours 24 and 72 within the range from 0.5 to 8 Gy and followed up until day 30 after irradiation with nonlethal (2 Gy) and lethal (8 Gy) doses. The total NA content in the leucocytes was determined by the method of Kritski and Aleksandrov. The uneven irradiation of rats within the 0,5-8 Gy range induced early dose-dependent changes in NA content. The nature of their post-irradiation dynamics also depended on the radiation dose and ...

British Library Electronic Table of Contents (United Kingdom)

Most heat shock proteins (Hsps) function as molecular chaperones that help organisms to cope with stress. Although the best empirical evidence is related to heat shock, there is evidence that Hsps and their encoding genes are involved in resistance to other ecologically relevant types of stresses such as those imposed by high population density. We quantified density-dependent gene expression of large (i.e. Hsp40, Hsc70 and Hsp90) and small (Hsp20.5, Hsp20.6 and Hsp20.7) heat shock genes in neural tissue of fifth-instar nymphs of the Australian plague locust, Chortoicetes terminifera, using reverse transcription-quantitative PCR. Locusts are of particular interest when studying the influence of stress induced by high population density since they show an extreme form of phenotypic plastici...

International Nuclear Information System (INIS)

By using a variational Monte Carlo method, we examine an effective low-energy model for LaFeAsO derived from an ab initio downfolding scheme. We show that quantum and many-body fluctuations near the antiferromagnetic (AF) quantum critical point largely reduce the antiferromagnetic ordered moment. Our derived model not only quantitatively reproduces the small ordered moment in LaFeAsO, but also accounts for the diversity from LaFePO, BaFe_2As_2 to FeTe. Electron correlation is found to determine the observed material dependence. We also find that LaFeAsO is subject to large orbital fluctuations, sandwiched by the AF Mott insulator and weakly correlated metals. The orbital fluctuations and Dirac-cone dispersion hold keys for the diverse magnetic properties. (author)

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Forensic signatures are present in any Pu sample that can determine the sample`s origin: isotopic ratio of Pu, progeny species that grow into the sample, and contaminant species left over from incomplete purification of the Pu in fuel reprocessing. In the context of intelligence information, this can result in attribution of responsibility for the product of clandestine proliferant operations or material smuggled from existing stockpiles. A list of signature elements and what can be determined from them have been developed. Work needs to be done in converting concentrations of signature species into a quantitative forensic analysis, particularly in regard to reactor performance, but this should require only a small effort. A radiochemical analysis scheme has been developed for measuring these nuclides; more work is needed, particularly for determining fission product concentrations. A sample of Pu metal has been analyzed and several parameters ...

British Library Electronic Table of Contents (United Kingdom)

Bacterial cellulose produced by the gram-negative bacterium Gluconacetobacter xylinum was found to be an excellent native starting material for preparing shaped ultra-lightweight cellulose aerogels. The procedure comprises thorough washing and sterilization of the aquogel, quantitative solvent exchange and subsequent drying with supercritical carbon dioxide at 40 degreeC and 100 bar. The average density of the obtained dry cellulose aerogels is only about 8 mg cm-3 which is comparable to the most lightweight silica aerogels and distinctly lower than all values for cellulosic aerogels obtained from plant cellulose so far. SEM, ESEM and nitrogen adsorption experiments at 77 K reveal an open-porous network structure that consists of a comparatively high percentage of large mesopores and small...

UK PubMed Central (United Kingdom)

ObjectiveAnimal feeding practices in the United States have changed considerably over the past century. As large-scale, concentrated production methods have become the predominant...Full Text Available

UK PubMed Central (United Kingdom)

Although many studies have examined the performance of animals in detecting a frequency change in a sequence of tones, few have measured animals' discrimination of the fundamental frequency...Full Text Available

CERN Document Server

Regulatory genes called small RNAs (sRNAs) are known to play critical roles in cellular responses to changing environments. For several sRNAs, regulation is effected by coupled stoichiometric degradation with messenger RNAs (mRNAs). The nonlinearity inherent in this regulatory scheme indicates that exact analytical solutions for the corresponding stochastic models are intractable. Here, we present a variational approach to analyze a well-studied stochastic model for regulation by sRNAs via coupled degradation. The proposed approach is efficient and provides accurate estimates of mean mRNA levels as well as higher order terms. Results from the variational ansatz are in excellent agreement with data from stochastic simulations for a wide range of parameters, including regions of parameter space where mean-field approaches break down. The proposed approach can be applied to quantitatively model stochastic gene expression in complex regulatory ...

Energy Technology Data Exchange (ETDEWEB)

Two-phase flow patterns and frictional pressure gradients in flow in small, rectangular channels are being studies as part of a larger research program addressing phase-change heat transfer of pure refrigerants and refrigerant mixtures in plate-fin heat exchangers. Small rectangular flow channels were selected as representative of plain fin geometries. The particular channel reported herein has dimensions of 19.05 {times} 3.18 mm. Adiabatic flows of air/water mixtures, with the flow channel horizontal and the channel exit at near-atmospheric conditions, were utilized in the experiments. Analysis and interpretation of the pressure data relative to observed flow pattern transitions led to an objective method for determining the plug/bubble-to-slug flow transition. This method, together with visual observations, supplemented with photographic data, was used to develop a flow pattern man. A comparison of existing flow pattern maps for circular ...

KoreaScience (Korea)

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International Science & Technology Center (ISTC)

Epizootological Monitoring of Brucellosis and Methods of its Eradication in the Kyrgyz Republic

International Nuclear Information System (INIS)

Understanding human brain function, brain development and brain dysfunction is one of the great challenges of the twenty first century. Biomedical imaging has now run up against a number of technical constraints that are exposing limits to its potential. In order to overcome the current limits to high-field magnetic resonance cerebral imaging (MRI) and unleash its fullest potential, the Cea has built NeuroSpin, an ultra-high-field neuroimaging facility at its Saclay centre (in the Essonne). NeuroSpin already boasts three fully operational MRI systems. The first is a 3-tesla high-field system and the second is a very-high-field 7-tesla system, both of which are dedicated to clinical studies and investigations in humans, while the third is an ultra-high-field 17.65-tesla system designed for studies on small animals. In 2011, NeuroSpin will be commissioning an 11.7-tesla ultra-high-field system of unprecedented power that is designed for research ...

Energy Technology Data Exchange (ETDEWEB)

The effect of adriamycin in combination with radiation on the skin reactions of mouse feet has been examined under a variety of experimental conditions including: (a) hyperthermic treatment of the foot immediately following adriamycin administration, with the former given either just before or just after x irradiation, and (b) fractionated treatments of drug and radiation in a variety of sequences over an 18-day period. In the case of the most severe hyperthermic treatment, no increased radiation reactions were observed in the presence of adriamycin. However, in the case of the less severe hyperthermic treatment a small but significant increase in skin reactions was observed. In the study of fractionated drug and radiation treatments, an enhancement of reaction in those animals receiving combined modality treatment over those receiving radiation alone was seen in those groups where the initiation of drug treatment succeeded the initiation of ...

International Nuclear Information System (INIS)

Eight percent of an intramuscular injection of 27.6 nCi of "2"3"7Pu(NO_3)_4 was retained by rats at the injection site, after 22 days. More than 30% is usually retained following injection of more massive quantities of "2"3"9Pu. Treatment with Ca- or Zn-DTPA showed the former to be more effective when treatments were initiated 1 hr after Pu administration. When treatments were begun 7 days after the Pu injection, 416 nmol Ca-DTPA/kg was more effective in removing Pu than 28.7 nmol/kg (human dose level) of Zn- or Ca-DTPA. Due to its high specific activity and ease of detection, "2"3"7Pu permits facile experimentation in small animals at Pu mass levels comparable to those encountered in most human exposures.

DEFF Research Database (Denmark)

Persistent hepatitis C virus (HCV) infection affects 170 million people worldwide. Acute HCV infection is often asymptomatic, but many infected individuals develop persistent infections that may lead to development of end-stage liver diseases, including liver cirrhosis and hepatocellular carcinoma. Thus, an HCV vaccine that could significantly lower the chronicity rate would have a major impact on the disease burden. Unfortunately, HCV is a highly mutable virus, and escape mutations can undermine vaccine-induced virus-specific immunity. Also, HCV exists as multiple genotypes, and so genotype-specific vaccines might be required to achieve broad protection. Finally, vaccine development has been hampered by the lack of a small animal model and cell culture systems, but these are currently being established. Despite these obstacles, several vaccine candidates tested in the chimpanzee HCV model have shown some encouraging results.

International Nuclear Information System (INIS)

Cardiac disease research relies increasingly on small animal models and non-invasive imaging methods such as positron emission tomography (PET) and magnetic resonance imaging (MRI). Delayed enhancement magnetic resonance imaging (DE-MRI) using gadolinium-based contrast agents appear to be a visualizing infracted myocardium with high spatial resolution. Polar map (or bull's-eye image) was used to determination of the myocardial infarction area. Polar map is a comprehensive interpretation of the left ventricle. The infarct size was computed as the fraction of the total polar map areas. The threshold was computed as the percentage of mean intensity of the normal region. In other study, 50% predefined threshold value in varying range (30?70%) was most commonly use. However, predefined threshold value isn't acceptance in all case. The purpose of this study was to investigate methodological approach for automatic measurement of rat myocardial infarct ...

International Nuclear Information System (INIS)

The suggestion has often been made that an additional radiation exposure imposed on humanity as a result of some important activity such as electricity generation would be acceptable if the exposure was 'small' compared to the natural background. In order to make this concept quantitative and objective, we propose that 'small compared with the natural background' be interpreted as the standard deviation (weighted with the exposed population) of the natural background. We believe that this use of the variation in natural background radiation is less arbitrary and requires fewer unfounded assumptions than some current approaches to standard-setting. The standard deviation is an easily calculated statistic that is small compared with the mean value for natural exposures of populations. It is an objectively determined quantity and its significance is generally understood. Its determination does not omit any ...

Energy Technology Data Exchange (ETDEWEB)

One such agent is the widely used anesthetic, halothane. To study the toxicity of u.v. decomposed halothane, mice were exposed to anesthetic concentrations (1.3%) of non- and u.v.-irradiated halothane in oxygen for 90 min. Halothane sleeping times increased from 14.3 min to 72.5 min. Microsomal mixed function oxidase activity decreased, as shown by prolonged pentobarbital sleeping times 1 day after exposure to halothane and irradiated halothane (54.6 min and 149.1 min, respectively, as compared to a 34.6-min control). Quantitative and qualitative differences were found in the amount of (/sup 14/C)-pentobarbital metabolites excreted by u.v. irradiated halothane-exposed mice compared to either oxygen or non-irradiated halothane-exposed groups. In addition, serum glutamic-oxalacetic transaminase (SGOT) of irradiated halothane-exposed mice increased to 233% of the control values, and serum glutamic-pyruvic transaminase (SGPT) were 377% of control values. No significant ...

International Nuclear Information System (INIS)

This study was designed to quantitate the dose resulting from lead exposure during the critical periods of brain development during gestation by determining: (1) if blood lead concentration in rat dams is affected by pregnancy status or duration of lead exposure, (2) if lead concentration in fetuses is associated with the duration of dam exposure, (3) the rates of lead absorption and elimination in pregnant and nonpregnant dams; and (4) the effect that prebreeding exposure on lead kinetics in the dam and upon fetus blood lead concentrations. The results of experiments in which the dams' drinking water contained 50 mg/L lead indicate blood lead levels (after normalizing by water consumption on a body weight basis) of pregnant rats are significantly higher than blood lead levels of non-pregnant rats. Statistical differences in blood lead levels were observed by day 15 of gestation and continue through day 20 of gestation. These blood lead differences are not due to ...

UK PubMed Central (United Kingdom)

The evaluation of biological markers is recognized as necessary to the future of toxicology, epidemiology, and quantitative risk assessment. For biological markers to become widely accepted, their validity...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

{sup 188}Re is a {beta}{sup -} (Emax=2.12 MeV) and {gamma} (155 keV) emitter. Since its chemistry is similar to that of the largely employed tracer, {sup 99m}Tc, molecules of hyaluronic acid (HA) have been labelled with {sup 188}Re to produce a target specific radiopharmaceutical. The radiolabeled compound, i.v. injected in healthy mice, is able to accumulate into the liver after a few minutes. To study the effect of metabolic radiotherapy in mice, we have built a small gamma camera based on a matrix of YAP:Ce crystals, with 0.6x0.6x10 mm{sup 3} pixels, read out by a R2486 Hamamatsu PSPMT. A high-sensitivity 20 mm thick lead parallel-hole collimator, with hole diameter 1.5 mm and septa of 0.18 mm, is placed in front of the YAP matrix. Preliminary results obtained with various phantoms containing a solution of {sup 188}Re and with C57 black mice injected with the {sup 188}Re-HA solution are presented. To increase the space resolution and to obtain two orthogonal ...

Energy Technology Data Exchange (ETDEWEB)

For quantitative acquisition of the influence of surface decarburizing phenomena on the failure of construction parts under cyclic stress different surface decarburization stages were generated in the steels 42CrMo4 and 100Cr6. After construction part-specific thermal treatment the generated states of residual stress were then determined and life span-oriented fatigue tests were conducted. The studies showed that already a small decarburization in martensitic material conditions of the steels 42CrMo4 and 100Cr6 led to a reduction of the alternating bending strength. The decrease of alternate strength can be associated with the micro-notch effects caused by the internal oxides formed by surface oxidation and/or the residual tension stress developed during the hardening in sub-surface sample areas. Decarburization degrees of more than 50% cause a noticeable decrease of surface stability, an increase of residual tension stresses close to the ...

International Nuclear Information System (INIS)

We propose to investigate the spontaneous emission of radiation arising out of the interaction of a relativistic electron beam with a metallic grating (the Smith-Purcell effect). The work will concentrate, primarily, in the 50-120 #mu#m part of the infrared spectrum and will be an extension of the work begun by the Oxford-Dartmouth-Essex collaboration; one of the early objectives of the project will be to develop a quantitative understanding of the power spectrum of the emitted radiation over a wide range of emission angles. In particular, the limits of relativistic peaking of forward directed emission will be investigated. The electron beam will be produced by laser irradiation of a metallic cathode in the terminal of a small Van de Graff accelerator located in the Technische Universitaet, Muenchen. Beam energies will be in the range of 2 - 4 MeV. Initial tests on photoproduction of electrons have yielded 10 mA pulses with a width of about 20 ...

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A comprehensive experimental program on pullout tests of steel fibers from cement based matrices is described. A specially designed single fiber pullout apparatus was used to provide a quantitative determination of interfacial properties that are relevant to toughening brittle materials through fiber reinforcement. The parameters investigated included a specially designed high strength cement based matrix called Densified Small Particles system (DSP), a conventional mortar matrix, fiber embedment length, and the fiber volume fraction. The mediums from which the fiber was pulled included a control mortar mix without fibers, a mortar mix with 3, and 6 percent fibers by volume. The results indicate that: (1) the dense DSP matrix has significantly improved interfacial properties as compared to the conventional mortar matrix. (2) Increasing the fiber embedment length and the fiber volume fraction in the cement matrix increase the peak pullout load ...

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The decays of charmed mesons into two body nonleptonic final states are investigated. Weak interaction amplitudes of interest in these decays are extracted from lattice four-point correlation functions using a effective weak Hamiltonian including effects to order G{sub f} in the weak interactions yet containing effects to all orders in the strong interactions. The lattice calculation allows a quantitative examination of non-spectator processes in charm decays helping to elucidate the role of effects such as color coherence, final state interactions and the importance of the so called weak annihilation process. For D {yields} K{pi}, we find that the non-spectator weak annihilation diagram is not small, and we interpret this as evidence for large final state interactions. Moreover, there is indications of a resonance in the isospin {1/2} channel to which the weak annihilation process contributes exclusively. Findings from the lattice calculation ...

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Gene analysis was used to determined the presence, abundance and phylogenetic affiliation of methanogens that exist in gas-hydrate-bearing sediment samples obtained from 23 drill cores from the JAPEX/JNOC/GSC et al. Mallik 5L-38 gas hydrate research well. Rates of methane production were examined using sediment-inoculated enrichments containing {sup 14}C-labeled carbon substrates, carbon dioxide and acetate. Archaeal 16S rDNA was only detected in 6 of the samples, resulting in 8 sequences with relationships to the Miscellaneous Crenarchaeotic Group (7 clones) and the Subsurface Euryarchaeotic Group (1 clone). The single Euryarchaeota sequence did not appear to be related to methanogens. Subsamples from the cores showed variable results upon DNA extraction and amplification. Methanogenic Coenzyme M (CoM) was detected in 13 of the 20 cores, but methanogenic methyl CoM reductase genes were not amplified from the samples when using a sensitive quantitative polymerase ...

Science.gov (United States)

Abnormal intracellular deposition of aggregated ?-synuclein is the characteristic feature of a number of neurological disorders, including Parkinson's disease (PD). Although ?-synuclein is typically known as a cytosolic protein, a small amount is secreted by exocytosis in both monomeric and aggregated forms. The extracellular forms of ?-synuclein in human body fluids, such as cerebrospinal fluid (CSF) and blood plasma, might be a diagnostic target for PD and related diseases. Here, we characterized a new set of monoclonal antibodies against ?-synuclein, and using different combinations of antibodies, we established ELISA systems to specifically detect human ?-synuclein, mouse and human ?-synuclein together, and multimeric forms of ?-synuclein in biological samples. By employing the Tyramide signal amplification method, the sensitivity of the assay was significantly improved to detect a concentration as low as ?12.5 pg/ml. These assays might be useful tools for ...

International Nuclear Information System (INIS)

A Digital X-ray imaging system using Compton backscattering has been developed to obtain a cross-sectional profile and mass loss of corroded lap-splices of aging aircraft from density variation. A slit-type camera was designed to focus on a small scattering volume inside the material, from which the backscattered photons are collected by a collimated scintillator detector for interpretation of material characteristics. The cross section of the lap-joint is scanned by moving the scattering volume through the thickness direction of the specimen. The mass loss of each layer has been estimated from a Compton backscatter A-scan to obtain the thickness of each layer including the aluminum sheet, the corrosion layer and the sealant. Quantitative information such as location and width of planar corrosion in the lap splices of fuselages is obtained by deconvolution using a nonlinear least-square error minimization method(BFGS method): A simple ...

International Nuclear Information System (INIS)

In the framework of the development of burnup calculation method for commercial fast reactors, a sensitivity analysis was carried out to clarify the dependence of fuel burnup characteristics on nuclear data libraries (NDLs). The following NDLs were compared: JEF-2.2, ENDF/B-VI Release 5, JENDL-3.2 and JENDL-3.3. The NDL-dependence of material balance for main heavy metal nuclides ("2"3"5U, "2"3"8U, "2"3"9Pu, "2"4"0Pu and "2"4"1Pu) was small, since the number densities at the end of one-cycle burnup did not change over 1 or 2% among the above-mentioned libraries. Relatively large differences were found for minor actinide nuclides, especially for "2"3"6U, "2"3"7Np, "2"4"2"mAm, "2"4"3Am and curium isotopes. The number densities for these nuclides after burning up showed remarkable NDL-dependence over 5% through 50%. A burnup sensitivity analysis system based on the generalized perturbation theory enabled us to find out quantitatively the causative ...

International Nuclear Information System (INIS)

Since 1988, the Expertise group of Molecular and Cellular Biology (MCB) is an important partner in the development of the Micro-Ecological Life Support System Alternative (MELiSSA). The MELiSSA was designed to allow a small crew to survive on an Antarctic, lunar or Mars outpost, and is a joint research project currently fostered by the European Space Agency, ESA. The MELiSSA functions through a series of five interconnected compartments, of which four are microbial bioreactors and was engineered to degrade organic waste, regenerate the outpost's atmosphere and water, and provide the crew with an additional vegetarian diet. The bioreactor of the third compartment provides the edible cyanobacteria and plants of the fourth compartment with nitrate instead of ammonium as a source of nitrogen. The two bacteria responsible for the biological transformation of ammonium to nitrate (nitrification) are Nitrosomonas europaea and Nitrobacter winogradskyi. Since all ...

UK PubMed Central (United Kingdom)

For terrestrial animals and plants, a fundamental cost of living is water vapor lost to the atmosphere during exchange of metabolic gases. Here, by bringing together previously developed models for...Full Text Available

UK PubMed Central (United Kingdom)

The technology of gene targeting through homologous recombination has been extremely useful for elucidating gene functions in mice. The application of this technology was thought impossible in the large...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundNematoda diverged from other animals between 600–1,200 million years ago and has become one of the most diverse animal phyla on earth. Most nematodes are free-living...Full Text Available

UK PubMed Central (United Kingdom)

Many animals use the spectral distribution of light to guide behaviour, but whether they have colour vision has been debated for over a century. Our strong subjective experience of colour and the fact...Full Text Available

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This section presents background information supporting the development of effluent limitations guidelines and standards for the concentrated aquatic animal production (CAAP) point source category. Section 1.1 presents the legal authority to regulate the ...

UK PubMed Central (United Kingdom)

Pesticide chemicals are an important component of modern agriculture. Through their use, plants and animals are exposed to pesticides directly and indirectly from transport through soil, water, and...Full Text Available

UK PubMed Central (United Kingdom)

Antinociceptive and anti-inflammatory activities of the ethanol extract from Annona muricata L. leaves were investigated in animal models. The extract delivered per oral route (p.o.)...Full Text Available

Science.gov (United States)

This series of animations depicts the results of a computer simulation of the effects of deforestation on the surface temperature and precipitation in the Amazon region. Six animations are shown - a control simulation, a deforestation simulation, and the difference between the two for both surface temperature and rainfall. The period simulated is the second half of 1987.

Science.gov (United States)

Feb 25, 2008 ... NASA's Visible Earth catalog of NASA images and animations of our home planet.

Science.gov (United States)

The objective of this animation is to develop a QTL mapping population for locating and characterizing the genes responsible for resistance to tan spot disease of wheat.

International Nuclear Information System (INIS)

Published in summary form only.

Energy Technology Data Exchange (ETDEWEB)

Published in summary form only.

International Nuclear Information System (INIS)

Published in summary form only.

International Nuclear Information System (INIS)

Japanese (Jan 1986). Japan Taniguchi, Yoshiyuki Torizumi, Kazutami Katu,

Energy Technology Data Exchange (ETDEWEB)

Part I of this thesis is on long-term iceberg collision-risk assessment methods for fixed offshore structures. Estimates for the long-term probability that an iceberg will hit a fixed offshore structure are based on estimates of the total volume of produced iceberg, a model for the size distribution of icebergs and a description of how iceberg trajectories ``fill`` the plane (the ocean`s surface). Part II of the thesis discusses methods for analysis of low resolution data in the sense that the size of the area covered by each pixel is not small compared to the dominating floes. Still, this type of data can provide estimates of the ice extent (and hence the ice edge) and ice concentration. The estimates of the ice edge (at least) seem to be physically significant in the sense that ``in some way`` they can reflect ice drift in an image time sequence. A priori this is far from obvious. A central idea is that the ``ice edge`` is close to a transition zone between two ...

Science.gov (United States)

Endothelial dysfunction and increased platelet aggregation may be involved in the pathogenesis of normal tissue radiation toxicity. This study assessed clopidogrel, an inhibitor of ADP-induced platelet aggregation, as a modulator of intestinal radiation injury (radiation enteropathy). Rat small intestine was exposed to 21 Gy X-radiation. Clopidogrel (20 mg/kg/day) or vehicle was administered from 2 days before to 10 days after irradiation. Structural radiation injury, neutrophil infiltration, smooth muscle cell proliferation, collagen content, and TGF-beta1 expression were assessed 2 weeks (early phase) and 26 weeks (delayed phase) after irradiation, using quantitative histology and immunohistochemistry, morphometry, and real-time fluorogenic probe RT-PCR. Irradiated intestine exhibited significant histopathologic injury, reduced mucosal surface area, vascular sclerosis, intestinal wall fibrosis, increased collagen content, and increased ...

Energy Technology Data Exchange (ETDEWEB)

Purpose: The determination of tumor volume in ocular tumors is very important for the planning and success of radiation therapy. This study uses an animal model to evaluate the accuracy of MR-based volumetry of ocular tumors. Materials and methods: In a total of 25 porcine eyes obtained from the slaughterhouse, ocular tumors were produced by injecting a mixture of hand creme and Gd-DTPA under ophthalmoscopic guidance. The injected volume varied between 0.05 ml and 2.7 ml. The eyes were examined with a 1.5 Tesla scanner and a 4 cm circular surface coil especially developed for ocular MRI. After data transfer to a separate workstation, volumetric analysis was carried out by three independent radiologists using semiautomated software. The determined volume was compared with the injected volume. Results: Of the 25 prepared porcine eyes, 23 were suitable for volumetric analysis. The injection of the mixture of hand creme and GD-DTPA produced two different types of ...

CERN Document Server

Single-case and Small-n Experimental Designs

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Magnetite nanoparticles with high self-heating capacity and low toxicity characteristics are a promising candidate for cancer hyperthermia treatment. In order to achieve minimum dosage to a patient, magnetic nanoparticles with high heating capacity are needed. In addition, the influence of physiological factors on the heat capacity of a material should be investigated in order to determine the feasibility. In this study, magnetite nanoparticles coated with lauric acid were prepared by co-precipitation of Fe{sup 3+}:Fe{sup 2+} in a ratio of 2:1, 5:3, 3:2, and 4:3, and the pH was controlled using NaOH. Structural and magnetization characterization by means of X-ray diffractometry (XRD) and a superconducting quantum interference device (SQUID) revealed that the main species was Fe{sub 3}O{sub 4} and further showed that most of the nanoparticles exhibited superparamagnetic properties. All of the magnetic nanoparticles showed a specific absorption rate (SAR) increase that was linear with ...

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To evaluate a dose conversion factor from the `Working Level of Month` (WLM) of radon to the absorbed dose (mGy), the quality of radon and its progeny was assessed, and exposures controlled for each deposition region were planed as follows: 1) exposure of radon gas to the entire respiratory tract, 2) exposure of `unattached` fractions to the upper respiratory tract, 3) exposure of `attached` fractions onto ultrafine particles to the deep lung, 4) exposure of `attached` fractions onto fine particles to the lower respiratory tract, 5) exposure of `attached` fractions onto coarse particles to the upper respiratory tract. In this preliminary study, a prototype exposure system of radon and its progeny for small rodents was designed. A whole body exposure chamber with a volume of about 0.5 m{sup 3} was used, which it held 20 rats. The aging and mixing chamber separated by the exposure chamber had a volume of about 1 m{sup 3}. As career aerosols of radon progeny, carnauba ...

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It is anticipated that early in the next century manned missions into outer space will occur, with a mission to Mars scheduled between 2015 and 2020. However, before such missions can be undertaken, a realistic estimation of the potential risks to the flight crews is required. One of the uncertainties remaining in this risk estimation is that posed by the effects of exposure to the radiation environment of outer space. Although the composition of this environment is fairly well understood, the biological effects arising from exposure to it are not. The reasons for this are three-fold: (1) A small but highly significant component of the radiation spectrum in outer space consists of highly charged, high energy (HZE) particles which are not routinely experienced on earth, and for which there are insufficient data on biological effects; (2) Most studies on the biological effects of radiation to date have been high-dose, high dose-rate, whereas in space, with the ...

International Nuclear Information System (INIS)

In 65 adult rabbits of both sexes (2.5 to 6 kg) the following salvaging procedures were performed after simulated trauma: (1) Continuous suture line; (2) closure with fibrin sealant after temporary clamping; (3) hemisplenectomy with omental wrap; (4) suture fixation of fragments and slices of spleen tissue to the peritoneum; (5) suture fixation of spleen fragments to the omentum; (6) extraperitoneal subcutaneous transposition of spleen cubes. In addition, the likelihood of spontaneous splenosis was examined in a preliminary study involving 5 animals by introducing unattached spleen meal and fragments. Scanning was repeated 4 to 12 weeks postoperatively. The functional competence of minor parenchymal islands was also investigated with well counter measurements of organ and muscle tissue homogenates. Spontaneous splenosis after abdominal injuries was not found to be the rule. Salvaging procedures at the natural vascular hilus by sutures, fibrin sealant and ...

Science.gov (United States)

Organic farming (or ecological agriculture) is of growing importance in the agricultural sector worldwide. In the Nordic countries, 1-10% of the arable land was in organic production in 1999. Organic farming can be seen as an approach to agriculture where the aim is to create integrated, humane, environmentally and economically sustainable agricultural production systems. Principles like nutrient recycling, prevention rather than treatment and the precautionary principle are included in aims and standards. Animal welfare is another hallmark of organic livestock production but despite this, several studies have indicated severe health problems e.g. in organic poultry production in Denmark. Also the quality of animal food products in relation to human health, particularly the risk of zoonotic infections, has been debated. For these reasons there is a need for improvement of production methods and animal health status. Vets ...

UK PubMed Central (United Kingdom)

OBJECTIVETo assess the new quantitative bone scan parameters as markers of Charcot neuroosteoarthropathy (CNO) activity.RESEARCH DESIGN AND METHODSForty-two...Full Text Available

UK PubMed Central (United Kingdom)

A single radial hemolysis test was developed for quantitation of specific antibody to non-hemagglutinating viruses. With the human coronaviruses as models, this test utilizes the binding properties...Full Text Available

UK PubMed Central (United Kingdom)

Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which...Full Text Available

UK PubMed Central (United Kingdom)

The Electronic REference To access In vivo Concentrations (ERETIC) method was applied to ¹H HR-MAS spectroscopy. The accuracy, precision, and stability of ERETIC as a quantitative...Full Text Available

International Nuclear Information System (INIS)

The oral administration of 2,3-dihydroxybenzoic acid (DHB) to rats injected intravenously 1 hr previously with "2"3"9Pu citrate caused an increase in urinary excretion of Pu about 8 times that of animals treated with 0.9% NaCl (controls). Liver retention of Pu was decreased from 18% at 2 days in the control animals to 11% in DHB-treated rats. The skeletal retention was similarly reduced from 56% in the control group to 40% in the DHB-treated animals.

UK PubMed Central (United Kingdom)

SIMV (simulation and modeling of ventilation) is a quantitative system for the mathematical modeling and simulation of pulmonary...Full Text Available

International Nuclear Information System (INIS)

French 1979. p. 4.35-4.48. France Granier, R. Bittoun, J. Doury, P. Pattin,

Energy Technology Data Exchange (ETDEWEB)

Published in summary form only.

Science.gov (United States)

... animal through a mask by isoflurane and maintained by a balanced anesthesia, which consisted of an intramuscular injection of Innovar-vet (0.11 ...

UK PubMed Central (United Kingdom)

Contagious diseases are a threat to animal health and productivity, both nationally and at the farm level. This makes implementation of biosecurity measures to prevent their introduction and...Full Text Available

UK PubMed Central (United Kingdom)

Humans, like other animals, are exposed to a continuous stream of signals, which are dynamic, multimodal, extended, and time varying in nature. This complex input space must be transduced and sampled...Full Text Available

UK PubMed Central (United Kingdom)

Some biological effects of hypoglycin-A, a compound isolated from the fruit of Blighia sapida, have been investigated. Administration of this compound to animals caused drowsiness...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundNonsteroidal anti-inflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest these drugs act in part by blocking...Full Text Available

UK PubMed Central (United Kingdom)

Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory...Full Text Available

UK PubMed Central (United Kingdom)

A summary of the effects presented here is given in the table. The designation "factor present" implies that there is knowledge (from human or animal studies, or both) of a specific factor(s) present...Full Text Available

Science.gov (United States)

... Joint Staff and other US Military (ie, Army, Navy, Air ... The major products of this work are significant advances in ... Keywords: Dogs; Laboratory animals ...

UK PubMed Central (United Kingdom)

Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor...Full Text Available

UK PubMed Central (United Kingdom)

In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences...Full Text Available

Science.gov (United States)

Background Food additives are an integral part of the modern food system, but opinion polls showing most Europeans have worries about them imply an urgent need for ethical analysis of their use. Sources of data The existing literature on food ethics, safety assessment and animal testing. Areas of agreement Food additives provide certain advantages in terms of many people's lifestyles. Areas of controversy There are disagreements about the appropriate application of the precautionary principle and of the value and ethical validity of animal tests in assessing human safety. Growing points Most consumers have a poor understanding of the relative benefits and risks of additives, but concerns over food safety and animal testing remain high. Areas timely for developing research Examining the impacts of food additives on consumer sovereignty, consumer health and on animals used in safety testing should allow a ...

Science.gov (United States)

... Bisgard, GE, Ruiz, AV, Grover, RF & Will, JA, "Ventilatory control in the ... Watkins, BE, Riegle, GD & Heisey, SR, "Respiratory responses to ACTH and ...

UK PubMed Central (United Kingdom)

A review of the literature is provided for the topic of health-related research and power frequency electromagnetic fields. Minimal evidence for concern is present on the basis of animal and plant research....Full Text Available

International Science & Technology Center (ISTC)

Development of New Methods and Means of Assessing of Consequences of Radionuclide and Heavy Metal Salt Effect, Criteria of Forecasting Physiological State and Productivity of the Farm Animals under Conditions of Ecological Pollution of Environment

UK PubMed Central (United Kingdom)

In recent years, Clostridium species have rapidly reemerged as human and animal pathogens. The detection and identification of pathogenic Clostridium species...Full Text Available

Science.gov (United States)

diet and genetic obesity metabolic defects and inflammation. To determine the role of adipocyte death in promoting adipose tissue inflammation and insulin resistance in animal...

UK PubMed Central (United Kingdom)

Vibrios are ubiquitous and abundant in the aquatic environment. A high abundance of vibrios is also detected in tissues and/or organs of various marine algae and animals, e.g., abalones, bivalves, corals,...Full Text Available

UK PubMed Central (United Kingdom)

The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal...Full Text Available

UK PubMed Central (United Kingdom)

The presence of antibodies to Rickettsia prowazeki in domestic animals from several parts of Africa, and the isolation of this rickettsia from the blood of goats and sheep and from...Full Text Available

International Nuclear Information System (INIS)

Immunoassays are versatile analytical techniques that had a leading role in various clinical applications, during the last four decades. The studies carried out by Rosalyn Yalow, Solomon Berson and Roger Ekins in the 1960s gave a breakthrough in the development of this novel analytical method. Sensitivity up to femtomolar concentrations, high specificity and universal application to different classes of molecular species made immunoassay a very useful tool in analytical investigation. The expertise acquired by immunochemists in producing antibodies against any antigen and the ability of radiochemists in labeling the antigens with "1"2"5I without affecting the active site are the two main factors responsible for the above development. There are concerns about the safety and health of humans due to the high-level contamination of environment by pesticides, industrial compounds and metals, anabolic steroids in milk and meat products, and presence of mycotoxins in food and feed ...

Norwegian Open Research Archives (NORA)

Full Text Available

Energy Technology Data Exchange (ETDEWEB)

In nuclear fuel, in approximately one quarter of the fissions, one of the two formed fission products is gaseous. These are mainly the noble gases xenon and krypton with isotopes of xenon contributing up to 90% of the product gases. These noble fission gases do not combine with other species, and have a low solubility in the normally used uranium oxide matrix. They can be dissolved in the fuel matrix or precipitate in nanometer-sized bubbles within the fuel grain, in micrometer-sized bubbles at the grain boundaries, and a fraction also precipitates in fuel pores, coming from fuel fabrication. A fraction of the gas can also be released into the plenum of the fuel rod. With increasing fission, and therefore burn-up, the ceramic fuel material experiences a transformation of its structure in the 'cooler' rim region of the fuel. A subdivision occurs of the original fuel grains of few microns size into thousands of small grains of sub-micron sizes. ...

International Nuclear Information System (INIS)

Eddy current testing (ECT) method is widely used as the non-destructive evaluation (NDE) of the various kinds of material degradation occurring in nuclear power plants (NPPs) components including steam generator (SG) tubes. Detection of any defects or flaws in the steam generator tubes in the early stage is very important in maintenance of NPP for its primary role as the pressure boundary with thin wall thickness. Although the ECT technique provides lots of information for a SG management, it has a generic problem in its reliability due to a low ability in detect of small defects and some difficulty in a signal analysis. For the improvement of these shortcomings in conventional ECT, profile-MRPC (motorized rotating pancake coil) ECT technology was developed in KAERI. The key of this new technology is the development of new eddy current probes, designated as a diagnostic probe (D-probe). The D-probe is furnished with a simultaneous dual function of a defect ...

Energy Technology Data Exchange (ETDEWEB)

Thallium-201 myocardial imaging was performed in 80 children with coronary arterial lesions due to Kawasaki disease in order to assess the value of serial and exercise myocardial imagings. In eight of these children, abnormalities of the image were noted. Twenty children had serial thallium studies with an interval of three to 18 months, and five of these showed changes in the image including appearance of a new perfusion defect in one patient and improvement of perfusion defects in four. These changes of the myocardial image were correlated well with coronary angiographic findings obtained within a few days of the isotope studies. It was noted that the changes of the myocardial image were more frequently observed at relatively recent period recovered from Kawasaki disease. Exercise myocardial imaging using a bicycle ergometer was performed in eight children with coronary arterial lesions. In three an evidence of improvement of the myocardial perfusion was noted immediately after ...

International Nuclear Information System (INIS)

Forty-four patients with small cell carcinoma of the bronchus underwent CT and MR studies of the brain to detect cerebral metastases. All patients were studied with contrast-enhanced CT scans, short (T1-weighted) and long (T2-weighted), spin-echo (SE) and FLASH 90 grades sequences were also obtained. A quantitative comparison of the results was carried out to assess the sensitivity of the different techniques in the detection of brain metastases according to lesion diameter. Metastases were identified in 19/44 patients (43%). All techniques detected the lesions >2 cm; of the metastases <2 cm, 63/124 (51%) were detected only by GdDTPA SE-T1 and FLASH sequences and 11 more (9%) only by Gd-DTPA SE-T1 scans. All the lesions identified oh enhanced CT scans or on T2-weighted images were easily detected by Gd-DTPA scans. CT sensitivity was higher than that of pre-contrast SE-T1 and FLASH studies and only slightly lower than that of T2-weighted ...

International Nuclear Information System (INIS)

Anti-carcinoembryonic antigen monclonal antibody (MAb) CEA 102 was produced by immunization with purified CEA and the specific accumulation of radiolabeled CEA 102 in colorectal cancers was investigated by autoradiography of sugical specimens using Fuji Computed Radiography (FCR). Five patients with colorectal cancer were injected intravenously with "1"3"1I-labeled intact CEA 102 or its F(ab')_2. Primary tumor and liver metastases were successfully detected by external scanning with a gamma camera in 4 cases. Autoradiographic study of the surgical specimens using FCR showed predominant localization of "1"3"1I-labeled CEA 102 in primary tumors and liver metastases in all cases. Even a small liver metastasis (0.5 cm) was clearly visualized in the autoradiogram by FCR. The pixel distribution curves of the density of the respective tissues in the autoradiograms by FCR showed the heterogeneity of the distribution of administreted radiolabeled MAb in individual tumors, ...

Science.gov (United States)

... Research on development of combustible cartridge cases for small arms was conducted in Germany during World War II. ...

UK PubMed Central (United Kingdom)

Food animals are a potential source of CTX-M resistance genes for humans. We evaluated the transfer of the bla_CTX-M-9 gene from an animal strain of Salmonella enterica...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The feasibility of using desferrioxamine (DF), an iron chelator, as a therapeutic agent against paraquat (PQ/sup + +/) toxicity in male Sprague-Dawley rats was explored, based on the rationale of limiting toxic hydroxyl radical production from hydrogen peroxide by removing redox-active iron. Body weights, mortality, and lung histopathology were followed for periods up to 14 days after intraperitoneal injection of PQ/sup + +/ (20 or 25 mg/kg body weight) with or without concurrent daily subcutaneous injections of DF (300 mg/day). Animals receiving PQ/sup + +/ showed the expected typical patterns of mortality and of lung histopathology, namely: marked edema, subpleural hemorrhage, acute inflammation, perivascular mononuclear cell infiltrates, sloughing of alveolar and bronchiolar lining cells, and diffuse interstitial fibrosis. Desferrioxamine alone was non-toxic. Surprisingly, results when both PQ/sup + +/ and DF were administered indicated a failure of DF to ...

British Library Electronic Table of Contents (United Kingdom)

The investigations were conducted at the Center of Biotechnology and Molecular Diagnostics of the All-Russian Animal Husbandry Research Institute, where a number of valuable transgenic animals (rabbits, sheep, and pigs) have been produced over the course of 20 years. The article presents the blood indices of control and transgenic rabbits with an integrated insulin gene.

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Background: Cu-diacetyl-bis(N{sup 4}-methylthiosemicarbazone) [Cu-ATSM], although excellent for oncology applications, may not be suitable for delineating cardiovascular or neurological hypoxia. For this reason, new Cu hypoxia positron emission tomography (PET) imaging agents are being examined to search for a higher selectivity for hypoxic or ischemic tissue at higher oxygen concentrations found in these tissues. Two approaches are to increase alkylation or to replace the sulfur atoms with selenium, resulting in the formation of selenosemicarbazones. Methods: Three {sup 64}Cu-labeled selenosemicarbazone complexes were synthesized and one was screened for hypoxia selectivity in vitro using EMT-6 mouse mammary carcinoma cells. Rodent biodistribution and small animal PET images were obtained from BALB/c mice implanted with EMT-6 tumors. One alkylated thiosemicarbazone was synthesized and examined. Results: Of the three bis(selenosemicarbazone) ...

International Nuclear Information System (INIS)

AFFF has fabricated the (U, Pu)O_2 mixed oxide fuels for PHWRs, BWRs, PFBRs and FBTRs. The quantitative dissolution of the fuel samples are required within time for accurate determination of uranium-plutonium in chemical quality control laboratory. This paper describes the use of microwave heating technique in quantitative dissolution of (U, Pu)O_2 MOX (from 0.4% to 44% PuO_2). (author)

British Library Electronic Table of Contents (United Kingdom)

The aim of the present investigation was to study the effect of weather and available protection on the behaviour of outdoor-wintered beef cattle (Bos taurus). A herd of 78-85 cattle head was studied during four winter months in the Southwest of Sweden. Protection was offered by coniferous forest situated on and around the 12ha pasture, which we divided into protection categories. During 240h we observed 10 cows and 10 heifers as focal animals (each 3h/month) during day time and adjusted observation times to the altitude of the sun. Close to the animals and at an unprotected spot of the pasture we measured temperature, wind speed and solar radiation and combined these variables to a single measure called Wind Chill Temperature (WCT). During observations the animals were in the forest in 12...

British Library Electronic Table of Contents (United Kingdom)

Measuring HPA axis activity is the standard approach to the study of stress and welfare in farm animals. Although the reference technique is the use of blood plasma to measure glucocorticoid hormones (cortisol or corticosterone), several alternative methods such as the measurement of corticosteroids in saliva, urine or faeces have been developed to overcome the stress induced by blood sampling itself. In chronic stress situations, as is frequently the case in studies about farm animal welfare, hormonal secretions are usually unchanged but dynamic testing allows the demonstration of functional changes at several levels of the system, including the sensitization of the adrenal cortex to ACTH and the resistance of the axis to feedback inhibition by corticosteroids (dexamethasone suppression t...

British Library Electronic Table of Contents (United Kingdom)

The present study was designed to determine the exercise intensity equivalent to the metabolic aerobic/anaerobic transition of alloxan diabetic rats, through lactate minimum test (LMT), and to evaluate the effects of swimming exercise at this intensity (LM) on the glucose and protein metabolism of these animals. Adult male Wistar rats received alloxan (SD, alloxan-injected rats that remained sedentary) intravenously (30 mg kg?1 body weight) for diabetes induction. As controls (SC, vehicle-injected rats that remained sedentary), vehicle-injected rats were utilized. Two weeks later, the animals were submitted to oral glucose tolerance test (oGTT) and LMT. After the tests, some of the animals were submitted to swimming exercise training [TC (vehicle-injected rats that performed a 6-week exerc...

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... These assumptions are quantitatively investigated by calculating tie icldti\\e inportance of ... A modified lon-shore current model is used to study the ...

UK PubMed Central (United Kingdom)

A specific application of single photon emission tomography to the relative quantitation of the pituitary region is described together with the results obtained in 19 patients with pituitary adenoma...Full Text Available

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BACKGROUND: An approach to the study of the pharmacokinetics of drugs in the lung is to measure their concentrations in bronchial biopsy specimens. The main criticism of this technique is that bronchial...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Abstract: The current financial crisis has now led most major central banks to rely on quantitative easing. The unique Japanese experience of quantitative easing is the only experience which enables us to judge this therapy's effectiveness and the timing of the exit strategy. In this paper, we provide a new empirical framework to examine the effectiveness of Japanese monetary policy during the ''lost'' decade and quantify the effect of quantitative easing on Japan's activity and prices. We combine advantages of Markov-switching VAR methodology with those of factor analysis to establish two major findings. First, we show that the decisive change in regime occurred in two steps: it crept out from late 1995 and established itself durably in February 1999. Second, we show for the first time th...

Science.gov (United States)

... and high-quality photospheric-phase Type II SN spectra to constrain core- collapse SN explosions, massive star evolution, and distances in the Universe ...

International Science & Technology Center (ISTC)

Computer-Aided Prediction of Chemical Ecotoxicity on the basis of Quantitative Structure-Activity Relationships with the Use of Physico-Chemical Descriptors, Including H-bond Parameters

UK PubMed Central (United Kingdom)

AIM: To investigate the effects of gallbladder stones on motor functions of the gallbladder and the dynamics of bile flow in asymptomatic gallstone disease.METHODS: Quantitative hepatobiliary...Full Text Available

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OBJECTIVE AND DESIGNThis study used qualitative and quantitative methods to examine the reasons primary care physicians and nurses offered for their inability to initiate guideline-concordant...Full Text Available

UK PubMed Central (United Kingdom)

In this model, without dark matter, the flat rotation curves of galaxies and the mass-to-light ratios of clusters of galaxies are described quantitatively. The hypothesis is that the agent of gravitational...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Classical semiconductor physics has been continuously improving electronic components such as diodes, light-emitting diodes, solar cells and transistors based on highly purified inorganic crystals over the past decades. Organic semiconductors, notably polymeric, are a comparatively young field of research, the first light-emitting diode based on conjugated polymers having been demonstrated in 1990. Polymeric semiconductors are of tremendous interest for high-volume, low-cost manufacturing (''printed electronics''). Due to their rather simple device structure mostly comprising only one or two functional layers, polymeric diodes are much more difficult to optimize compared to small-molecular organic devices. Usually, functions such as charge injection and transport are handled by the same material which thus needs to be highly optimized. The present work contributes to expanding the knowledge on the physical mechanisms determining ...

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Zoonoses are infections that are spread from animals to humans. Most often, humans are “dead-end” hosts, meaning that there is no subsequent human-to-human transmission. If one considers...Full Text Available

Wastenet

...qualified and who were under consideration at the time, USDA Secretary Tom Vilsack chose an animal husbandry specialist employed by one of the largest organic livestock product marketers in the country. While this appointee had grown up on a conventional farm, her immediate occupation is not that of ...

UK PubMed Central (United Kingdom)

A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers...Full Text Available

UK PubMed Central (United Kingdom)

Borna disease virus (BDV) uses a unique strategy of replication and transcription which takes place in the nucleus, unlike other known, nonsegmented, negative-stranded RNA viruses of animal origin....Full Text Available

UK PubMed Central (United Kingdom)

The ability to enter a hypometabolic state upon restriction of caloric intake is pivotal for animal survival: balancing the energy budget in endotherms can be a real struggle when food is not...Full Text Available

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BackgroundAnimal mitochondrial genomes are physically separate from the much larger nuclear genomes and have proven useful both for phylogenetic studies and for understanding genome...Full Text Available

Science.gov (United States)

Thalassinid shrimp cause significant problems for oyster aquaculture in the Pacific Northwest (USA) where oysters succumb to the physical disruption of the sediment by the burrowing activity of these animals. While electrofishing is a commonly used technique to capture fish and some invertebrates i...

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Game theory models of animal contests make many non-mutually exclusive predictions, complicating empirical tests. These predictions regard the relationship between contest parameters and fighting ability,...Full Text Available

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Sustained metabolic rates (SusMR) are time-averaged metabolic rates that are measured in free-ranging animals maintaining constant body mass over periods long enough that metabolism is fueled by food...Full Text Available

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Oysters are permanently exposed to various microbes, and their defense system is continuously solicited to prevent accumulation of invading and pathogenic organisms. Therefore, impairment of the animal's...Full Text Available

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According to world statistics, dogs and cats are the species that owners most frequently seek assistance with potential poisonings, accounting 95–98% of all reported animal cases. Exposures...Full Text Available

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A retrospective study of the relationship of season to the absorption of radiolead in laboratory rats was performed using data representing 305 animals from 36 experiments over 6 calendar years. Male...Full Text Available

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The scaling of reproductive parameters to body size is important for understanding ecological and evolutionary patterns. Here, we derived allometric relationships for the number and mass of seeds, eggs...Full Text Available

Science.gov (United States)

Journal of Human Genetics. 82: 873-882. 3134. Schulz, I., Schneider, P. M., Olek, K, Rothschild, M. A., and Tsokos, M. (2006) Examination of Postmortem Animal Interference to Human...

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Phosphatidic acid (PA) is postulated to have both structural and signaling functions during membrane dynamics in animal cells. In this study, we show that before a critical time period during rhabdomere...Full Text Available

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The effects of homologous plasma HDL and VHDL fractions on established atherosclerotic lesions were studied in cholesterol-fed rabbits. Atherosclerosis was induced by feeding the animals a 0.5% cholesterol-rich...Full Text Available

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Failures in cortical control of fronto-striatal neural circuits may underpin impulsive and compulsive acts. In this narrative review, we explore these behaviors from the perspective of neural processes...Full Text Available

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Trichloroethylene (TCE) pharmacokinetics have been studied in experimental animals and humans for over 30 years. Compartmental and physiologically based pharmacokinetic (PBPK) models have been developed...Full Text Available

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BackgroundComplex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models.Methodology/Principal...Full Text Available

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Exposure of a group of horses to tetracycline-contaminated feed resulted in acute colitis and subsequent death in one horse and milder diarrhea in 3 others. The most severely affected animal demonstrated...Full Text Available

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Nuclear cloning is still a developing technique used to create genetically identical animals by somatic cell nuclear transfer into unfertilized eggs. Despite an intensive effort in a number...Full Text Available

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Naturally occurring, double-stranded RNA (ds-RNA)) was immunogenic when injected into mice, rats, guinea-pigs, rabbits, dogs and baboons. The response to native material administered intravenously (i.v.)...Full Text Available

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Chemical reactions in living cells are under strict enzyme control and conform to a tightly regulated metabolic program. However, uncontrolled and potentially deleterious endogenous reactions occur,...Full Text Available

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Despite the availability of dozens of animal genome sequences, two key questions remain unanswered: First, what fraction of any species' genome confers biological function, and second, are apparent...Full Text Available

Environmental Research Database

ObjectivesThe main objective of this study is to address the following specific questions: 1. Are the delayed effects of poor early diet on whole organism performance and senescence contingent on, or exacerbated by, the subsequent occurrence of compensatory growth? 2. Does the rate of growth influence levels of resting metabolism and/or oxidative stress, and if so, for how long does this persist? 3. How are the levels of early nutrition, growth, resting metabolism and oxidative stress linked to the lev [continued...]DescriptionIt is now widely appreciated that, while animals may appear to recover from periods of poor food quality or quantity experienced in early development, adverse effects may occur later in adult life. Such effects can influence the performance of complete cohorts of animals, and have important consequences for population dynamics. The reasons why such delayed effects occur across the animals' lifetimes ...

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Lepidoptera, butterflies and moths, is the second largest animal order and includes numerous agricultural pests. To facilitate comparative genomics in Lepidoptera, we isolated BAC clones containing...Full Text Available

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The effectiveness of chemotherapy in human schistosomiasis varies from one area to another, and limited data from experimentally infected animals suggest inherent differences in the susceptibility...Full Text Available

UK PubMed Central (United Kingdom)

The extent of our reliance on animal pollination for world crop production for human food has not previously been evaluated and the previous estimates for countries or continents have seldom used primary...Full Text Available

UK PubMed Central (United Kingdom)

Exposure of animals to hyperoxia decreases lung VEGF mRNA expression concomitant with an acute increase in VEGF protein within the epithelial lining fluid (ELF). The VEGF concentration in ELF...Full Text Available

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Heat shock proteins (Hsp) are a family of stress-inducible molecular chaperones that play multiple roles in a wide variety of animals. However, the roles of Hsps in parasitic nematodes remain largely...Full Text Available

UK PubMed Central (United Kingdom)

Data from exposure of experimental animals and human subjects to sulfuric acid presents a consistent picture of its toxicology. Effects on airway resistance in asthmatic subjects were well predicted...Full Text Available

Wastenet

... Contrary to this definition, abiotic environmental factors are those in which no organisms participate - e.g. the geological underground, light, temperature and heat. Biotope The biotope is an area of uniform environmental conditions providing living place for a specific assemblage of plants and animals....

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The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered....Full Text Available

UK PubMed Central (United Kingdom)

Available in vitro and animal studies have shown cancer protective effects of tea polyphenols. Recent study suggests a greater protective effect of green tea intake on breast cancer...Full Text Available

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Parasitic nematodes cause serious diseases in humans, animals, and plants. They have limited lipid metabolism and are reliant on lipid-binding proteins to acquire these metabolites from their hosts....Full Text Available

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Hematopoietic stem cells replenish all the cells of the blood throughout the lifetime of an animal. Although thousands of stem cells reside in the bone marrow, only a few contribute to blood production...Full Text Available

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Phenylpropenes such as chavicol, t-anol, eugenol, and isoeugenol are produced by plants as defense compounds against animals and microorganisms and as floral attractants of pollinators....Full Text Available

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The importance of intact host defense mechanisms for successful antimicrobial therapy was investigated in an animal model. Recovery from lobar pneumococcal pneumonia as a result of penicillin therapy...Full Text Available

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In both humans and songbirds, infants learn vocalizations by imitating the sounds of adult tutors with whom they interact during an early sensitive period. Vocal learning occurs in few animal taxa;...Full Text Available

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Metazoan life cycles can be complex in different ways. A number of diverse phenotypes and reproductive events can sequentially occur along the cycle, and at certain stages a variety of developmental...Full Text Available

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Conjugated linoleic acid (CLA) has been the subject of extensive investigation regarding its possible benefits on a variety of human diseases. In some animal studies, CLA has been shown to have a beneficial...Full Text Available

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Clostridium perfringens produces numerous toxins, which are responsible for severe diseases in man and animals. Delta toxin is one of the three hemolysins released by a number of C....Full Text Available

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Chondroitin sulphate (CS) is a glycosaminoglycan widely distributed in animal tissues, which has anti-inflammatory and chondroprotective properties. We reported previously that chondroitin 4-sulphate...Full Text Available

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The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis...Full Text Available

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We study the integration of multisensory and central input at the level of an identified fly motoneuron, the ventral cervical nerve motoneuron (VCNM) cell, which controls head movements of the animal....Full Text Available

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Hair is preserved for millennia in permafrost; it enshrines a record of biologic rhythms and offers a glimpse at chronobiology as it was in extinct animals. Here we compare biologic rhythms gleaned...Full Text Available

UK PubMed Central (United Kingdom)

The neuromodulatory function of dopamine (DA) is an inherent feature of nervous systems of all animals. To learn more about the function of neural DA in Drosophila, we generated mutant...Full Text Available

Science.gov (United States)

In biotechnology, acrylamide is being used in DNA and RNA analysis using the polyacrylamide gel electrophoreses procedure. Polymerized acrylamide is degraded into acrylamide through time; it is converted into a hazardous contaminant that is carcinogenic and neurotoxic to animals and humans. Because ...

UK PubMed Central (United Kingdom)

Background:The present study was undertaken to evaluate the anti-ulcer and antioxidant activities of the ethanol extract of Lagenaria breviflora (EELB)...Full Text Available

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Numerous epidemiological studies have consistently demonstrated that individuals who eat more fruits and vegetables (which are rich in carotenoids) and who have higher serum β-carotene levels...Full Text Available

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BackgroundThe goat (Capra hircus) represents one of the most important farm animal species. It is reared in all continents with an estimated world population of...Full Text Available

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Dopaminergic neurons of the ventral midbrain fire high frequency bursts when animals are presented with unexpected rewards, or stimuli that predict reward. To identify the afferents that can...Full Text Available

UK PubMed Central (United Kingdom)

A remarkable discovery of recent years is that, despite the complexity of ageing, simple genetic interventions can increase lifespan and improve health during ageing in laboratory animals. The pathways...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundStorage of RBCs is necessary for an adequate blood supply. However, reports have identified potential negative sequelae of transfusing stored RBCs. An animal...Full Text Available

UK PubMed Central (United Kingdom)

Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates...Full Text Available

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...1) A privately owned motor vehicle. (2) A privately owned boat. (3) An indigenous animal, military working dog, or guide dog for the blind or visually-impaired accompanying its owner. (4) A narcotic or dangerous drug or...

Science.gov (United States)

A mathematical model of 137Cs migration in forest ecosystem is presented, which describes the behaviour of this radionuclide in the forest litter-soil system, trees, understory and forest animals. The model's parameters for different types of forest ecosystems are estimated and model's adequacy is tested through the use of independent experimental data. The sensitivity of the model's output variables is analyzed to variations in the most significant parameters. The differences in the seasonal and mean annual dynamics of 137Cs concentration in muscles of roe deers and mooses are shown to be defined by specific features of the diets of these animals and variations in 137Cs content in the main diet components. PMID:11402557

International Nuclear Information System (INIS)

Direct determination of "2"3"2U and its decay products in animal tissues appears to be feasible using an intrinsic Ge(Li) diode detector (for energies of 5-100 keV) and a NaI(Tl) anticoincidence-shielded Ge(Li) diode for higher-energy gamma photons. The detection sensitivity for "2"3"2U and "2"2"8Th is 0.03 and 0.01 nCi, respectively, using a 300-min counting time.

International Nuclear Information System (INIS)

The effect of protein malnutrition on the metabolism of collagen in bone was studied in young female albino rats after a single injection of "3H-proline. Both specific and total radioactivities of hydroxyproline in the total collagen of the bone were found to decrease in the protein-deficient animals, indicating decreased rate of collagen synthesis. In the urine the amount of hydroxyproline excreted and total radioactivity of "3H-hydroxyproline were greatly decreased. The results of the present investigation therefore clearly indicate decreased synthesis and catabolism of collagen in bones of protein deficient animals compared to controls. (auth.).

Science.gov (United States)

... Abstract : Small metallic fragments can be trapped in combustible cartridge cases during manufacture and released into the interior-ballistic flow ...