British Library Electronic Table of Contents (United Kingdom)

Introduction: The QT interval of the electrocardiogram (ECG) reflects the duration of ventricular depolarization and repolarization. A drug-induced prolongation of ventricular repolarization, and thereby QT prolongation, is recognized to be a marker for an enhanced risk for ventricular arrhythmia. The assessment of a drug's effect on the QT interval has therefore become routine within pharmaceutical research and development. However, the heart rate has a major influence on the QT interval; the QT interval shortens as heart rate increases such that one needs to account for such heart rate-dependent changes when evaluating possible drug-induced effects on the QT interval. The relationship between the QT interval and heart rate can be modeled mathematically and using this function a so-called...

Energy Technology Data Exchange (ETDEWEB)

Effects of PbO on the repassivation kinetics of alloy 690TT were examined using the rapid scratching electrode technique under a potentiostatic condition to elucidate the influence of PbO on SCC resistance of the alloy. The repassivation kinetics of the alloy was analyzed in terms of the current density flowing from the scratch, i(t), as a function of the charge density that has flowed from the scratch, q(t). Repassivation on the scratched surface of the alloy occurred in two kinetically different processes; passive film initially nucleated and grew according to the place exchange model in which log i(t) is linearly proportional to q(t) with a slope of 1/K, and then grew according to the high field ion conduction model in which log i(t) is linearly proportional to 1/q(t) with a slope of cBV. 1/K and cBV are parameters representing the SCC susceptibility as well as repassivation rate of the alloy at an initial and an ...

Energy Technology Data Exchange (ETDEWEB)

The CPHR individual monitoring service acquired an automatic RADOS TLD system to improve its capacities to satisfy the increasing needs of their national customers. The TLD system consists of: two automatic TLD reader, model DOSACUS, a TLD irradiator and personal dosimeters card including slide and holders. The dosimeters were composed by this personal dosimeters card and LiF:Mg,Cu,P (model GR-200) detectors. These readers provide to detectors a constant temperature readout cycle using hot nitrogen gas. In order to evaluate the performance characteristics of the system, different performance tests recommended by the IEC 1066 standard were carried out. Important dosimetric characteristics evaluated were batch homogeneity, reproducibility, detection threshold, energy dependence, residual signal and fading. The results of the tests showed good performance characteristics of the system. (Author)

CERN Document Server

We compare N-body simulations of isolated galaxies performed in both frameworks of modified Newtonian dynamics (MOND) and Newtonian gravity with dark matter (DM). We have developed a multigrid code able to efficiently solve the modified Poisson equation derived from the Lagrangian formalism AQUAL. We take particular care of the boundary conditions that are a crucial point in MOND. The 3-dimensional dynamics of initially identical stellar discs is studied in both models. In Newtonian gravity the live DM halo is chosen to fit the rotation curve of the MOND galaxy. For the same value of the Toomre parameter (Q_T), galactic discs in MOND develop a bar instability sooner than in the DM model. In a second phase the MOND bars weaken while the DM bars continue to grow by exchanging angular momentum with the halo. The bar pattern speed evolves quite differently in the two models: there is no dynamical friction on the MOND bars so they keep a constant pattern speed while the ...