AP1000{sup R} design robustness against extreme external events - Seismic, flooding, and aircraft crash

Energy Technology Data Exchange (ETDEWEB)

Pfister, A.; Goossen, C.; Coogler, K.; Gorgemans, J. [Westinghouse Electric Company LLC, 1000 Westinghouse Drive, Cranberry Township, PA 16066 (United States)

2012-07-01

Both the International Atomic Energy Agency (IAEA) and the U.S. Nuclear Regulatory Commission (NRC) require existing and new nuclear power plants to conduct plant assessments to demonstrate the unit's ability to withstand external hazards. The events that occurred at the Fukushima-Dai-ichi nuclear power station demonstrated the importance of designing a nuclear power plant with the ability to protect the plant against extreme external hazards. The innovative design of the AP1000{sup R} nuclear power plant provides unparalleled protection against catastrophic external events which can lead to extensive infrastructure damage and place the plant in an extended abnormal situation. The AP1000 plant is an 1100-MWe pressurized water reactor with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance and safety. The plant's compact safety related footprint and protection provided by its robust nuclear island structures prevent significant damage to systems, structures, and components required to safely shutdown the plant and maintain core and spent fuel pool cooling and containment integrity following extreme external events. The AP1000 nuclear power plant has been extensively analyzed and reviewed to demonstrate that it's nuclear island design and plant layout provide protection against both design basis and extreme beyond design basis external hazards such as extreme seismic events, external flooding that exceeds the maximum probable flood limit, and malicious aircraft impact. The AP1000 nuclear power plant uses fail safe passive features to mitigate design basis accidents. The passive safety systems are designed to function without safety-grade support systems (such as AC power, component cooling water, service water, compressed air or HVAC). The plant has been designed to protect systems, structures, and components critical to placing the reactor in a safe shutdown condition within the steel

Westinghouse AP1000 licensing maturity

International Nuclear Information System (INIS)

Schulz, T.; Vijuk, R.P.

2005-01-01

The Westinghouse AP1000 Program is aimed at making available a nuclear power plant that is economical in the U.S deregulated electrical power industry in the near-term. The AP1000 is two-loop 1000 MWe pressurizer water reactor (PWR). It is an up rated version of the AP600. The AP1000 uses passive safety systems to provide significant and measurable improvements in plant simplification, safety, reliability, investment protection and plant costs. The AP1000 uses proven technology, which builds on over 35 years of operating PWR experience. The AP1000 received Final Design Approval by the United States Nuclear Regulatory Commission (U.S. NRC) in September 2004. The AP1000 meets the US utility requirements. The AP1000 and its sister plant the AP600 have gone through a very through and complete licensing review. This paper describes the U.S. NRC review efforts of both the AP600 and the AP1000. The detail of the review and the independent calculations, evaluations and testing is discussed. The AP600 licensing documentation was submitted in 1992. The U.S. NRC granted Final Design Approval in 1999. During the intervening 7 years, the U.S. NRC asked thousands of questions, performed independent safety analysis, audited Westinghouse calculations and analysis, and performed independent testing. The more significant areas of discussion will be described. For the AP1000 Westinghouse first engaged the U.S. NRC in pre-certification discussions to define the extent of the review required, since the design is so similar to the AP600. The AP1000 licensing documentation was submitted in March 2002. The U.S. NRC granted Final Design Approval in September 2004. During the intervening 2 1/2 years, the U.S. NRC asked hundreds of questions, performed independent safety analysis, audited Westinghouse calculations and analysis, and performed independent testing. The more significant areas of discussion will be described. The implications of this review and approval on AP1000 applications in

Measuring exposure in DDoS protection services

NARCIS (Netherlands)

Jonker, Mattijs; Sperotto, Anna

2017-01-01

Denial-of-Service attacks have rapidly gained in popularity over the last decade. The increase in frequency, size, and complexity of attacks has made DDoS Protection Services (DPS) an attractive mitigation solution to which the protection of services can be outsourced. Despite a thriving market and

To what extent can ecosystem services motivate protecting biodiversity?

Science.gov (United States)

Dee, Laura E; De Lara, Michel; Costello, Christopher; Gaines, Steven D

2017-08-01

Society increasingly focuses on managing nature for the services it provides people rather than for the existence of particular species. How much biodiversity protection would result from this modified focus? Although biodiversity contributes to ecosystem services, the details of which species are critical, and whether they will go functionally extinct in the future, are fraught with uncertainty. Explicitly considering this uncertainty, we develop an analytical framework to determine how much biodiversity protection would arise solely from optimising net value from an ecosystem service. Using stochastic dynamic programming, we find that protecting a threshold number of species is optimal, and uncertainty surrounding how biodiversity produces services makes it optimal to protect more species than are presumed critical. We define conditions under which the economically optimal protection strategy is to protect all species, no species, and cases in between. We show how the optimal number of species to protect depends upon different relationships between species and services, including considering multiple services. Our analysis provides simple criteria to evaluate when managing for particular ecosystem services could warrant protecting all species, given uncertainty. Evaluating this criterion with empirical estimates from different ecosystems suggests that optimising some services will be more likely to protect most species than others. © 2017 John Wiley & Sons Ltd/CNRS.

The Radiation Protection Service in Asuncion

International Nuclear Information System (INIS)

Zaldivar de Basualdo, I.

1979-01-01

This report details the activities of radiation protection services concerning radioisotopes, personal monitoring and film dosimetry service. Historical, organizational and regulatory aspects are also covered. (author)

25 CFR 20.403 - What do protective services include?

Science.gov (United States)

2010-04-01

....403 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES FINANCIAL ASSISTANCE AND SOCIAL SERVICES PROGRAMS Services to Children, Elderly, and Families § 20.403 What do protective services include? Protective services provided to a child, family or elderly person will be documented in...

Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor.

Directory of Open Access Journals (Sweden)

Izumi Kaneko

2015-05-01

Full Text Available Stage-specific transcription is a fundamental biological process in the life cycle of the Plasmodium parasite. Proteins containing the AP2 DNA-binding domain are responsible for stage-specific transcriptional regulation and belong to the only known family of transcription factors in Plasmodium parasites. Comprehensive identification of their target genes will advance our understanding of the molecular basis of stage-specific transcriptional regulation and stage-specific parasite development. AP2-O is an AP2 family transcription factor that is expressed in the mosquito midgut-invading stage, called the ookinete, and is essential for normal morphogenesis of this stage. In this study, we identified the genome-wide target genes of AP2-O by chromatin immunoprecipitation-sequencing and elucidate how this AP2 family transcription factor contributes to the formation of this motile stage. The analysis revealed that AP2-O binds specifically to the upstream genomic regions of more than 500 genes, suggesting that approximately 10% of the parasite genome is directly regulated by AP2-O. These genes are involved in distinct biological processes such as morphogenesis, locomotion, midgut penetration, protection against mosquito immunity and preparation for subsequent oocyst development. This direct and global regulation by AP2-O provides a model for gene regulation in Plasmodium parasites and may explain how these parasites manage to control their complex life cycle using a small number of sequence-specific AP2 transcription factors.

25 CFR 20.402 - When are protective services provided?

Science.gov (United States)

2010-04-01

... AND SOCIAL SERVICES PROGRAMS Services to Children, Elderly, and Families § 20.402 When are protective services provided? Protective services are provided when children or adults: (a) Are deprived temporarily or permanently of needed supervision by responsible adults; (b) Are neglected, abused or exploited...

Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations (I): catastrophic APS, APS nephropathy and heart valve lesions.

Science.gov (United States)

Cervera, R; Tektonidou, M G; Espinosa, G; Cabral, A R; González, E B; Erkan, D; Vadya, S; Adrogué, H E; Solomon, M; Zandman-Goddard, G; Shoenfeld, Y

2011-02-01

The objectives of the 'Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations' were to assess the clinical utility of the international consensus statement on classification criteria and treatment guidelines for the catastrophic APS, to identify and grade the studies that analyse the relationship between the antiphospholipid antibodies and the non-criteria APS manifestations and to present the current evidence regarding the accuracy of these non-criteria APS manifestations for the detection of patients with APS. This article summarizes the studies analysed on the catastrophic APS, APS nephropathy and heart valve lesions, and presents the recommendations elaborated by the Task Force after this analysis.

Advanced Protection & Service Restoration for FREEDM Systems

Science.gov (United States)

Singh, Urvir

A smart electric power distribution system (FREEDM system) that incorporates DERs (Distributed Energy Resources), SSTs (Solid State Transformers - that can limit the fault current to two times of the rated current) & RSC (Reliable & Secure Communication) capabilities has been studied in this work in order to develop its appropriate protection & service restoration techniques. First, a solution is proposed that can make conventional protective devices be able to provide effective protection for FREEDM systems. Results show that although this scheme can provide required protection but it can be quite slow. Using the FREEDM system's communication capabilities, a communication assisted Overcurrent (O/C) protection scheme is proposed & results show that by using communication (blocking signals) very fast operating times are achieved thereby, mitigating the problem of conventional O/C scheme. Using the FREEDM System's DGI (Distributed Grid Intelligence) capability, an automated FLISR (Fault Location, Isolation & Service Restoration) scheme is proposed that is based on the concept of 'software agents' & uses lesser data (than conventional centralized approaches). Test results illustrated that this scheme is able to provide a global optimal system reconfiguration for service restoration.

Building an SDN enterprise WLAN based on virtual APs

NARCIS (Netherlands)

Sequeira, L.; Cruz, J.L. de la; Ruiz-Mas, J.; Saldana, J.; Fernandez-Navajas, J.; Almodovar, J.

2017-01-01

In this letter, the development and testing of an open enterprise Wi-Fi solution based on virtual access points (APs), managed by a central WLAN controller is presented. It allows seamless handovers between APs in different channels, maintaining the QoS of real-time services. The potential

Study on modular construction management in AP1000 nuclear plant project

International Nuclear Information System (INIS)

Fang Xiaopeng; Shen Wenrong; Sun Kebin; Wei Zhong

2010-01-01

The construction of AP1000 Nuclear Power Plant (NPP) has commenced in China. The AP1000 NPP features a passive design concept and modular construction technology. Based on the management of the construction of current AP1000 NNP, this paper describes the effects on Nuclear Island (NI) construction project management resulting from modular construction technology, as well as new construction techniques and methods. This paper puts forward new requirements for construction schedule management of the nuclear island construction at different levels. The AP1000 NI construction logic features the parallel construction of civil and structural erection as the main approach, with the integrated schedule of module fabrication, assembly and installation as support. The structural modules of AP1000 project are prefabricated in shop, delivered to site as sub-modules and assembled to integrated structural module. The assembled module is transported to the construction site, hoisted and finally set in NI. This paper illustrates how to ensure the construction quality of structural modules by analyzing the interface process and key links in the quality control program, and introduces how to ensure the safety of heavy structural components during various construction phases by evaluating and analyzing the construction safety process. This paper also makes an analysis of the safe environment for the assembly and installation of Containment Vessel, the management of product protection and personnel safety inside the Containment Building during 'Open Top' construction, raises to implement effective protection for the numerous pre-set mechanical modules and equipments, as well as personnel safety protection programs and measures. The modular construction feature of AP1000 NPP design requires technique improvement and management innovation during the NI construction. This paper makes a study and research on the control management of schedule, quality and safety of AP1000 NPP NI

Enhancing the safety of elderly victims after the close of an APS investigation.

Science.gov (United States)

Jackson, Shelly L; Hafemeister, Thomas L

2013-04-01

The purpose of this study was to test whether particular actions on the part of adult protective services (APS), the elderly victim, and/or society's response to abusive individuals, are associated with the continuation of abuse after the close of an APS investigation and thereby compromise victim safety. Interviews were conducted with 71 APS caseworkers, 55 of the elderly victims of substantiated abuse, and 35 third-party persons. A small proportion of elderly victims continue to experience abuse after the close of an APS investigation. Elderly victims were more likely to experience continued abuse when they chose to have ongoing contact with their abusers, vis-à-vis cohabitation or otherwise, and when their abusers experienced no consequences. Although continuation of abuse did not differ by the type of maltreatment involved, reasons for the cessation of abuse, and other safety indicators, did. To enhance victim safety, greater monitoring may be warranted in cases wherein elderly victims continue to have contact with their abuser and when abusive individuals experience no consequences. To further enhance victim safety, abusive individuals must be incorporated into an overall strategic response to elder abuse. A potential avenue for facilitating victim safety while maintaining victim autonomy is to understand their motivations for desiring continued contact with their abuser and developing interventions based upon such knowledge.

CGM ApS Årsberetning til DANAK

DEFF Research Database (Denmark)

De Chiffre, Leonardo

Denne årsberetning omfatter CGM ApS' akkrediterede virksomhed i kalenderåret 2003. Årsberetningen er udarbejdet til DANAK (Dansk Akkreditering, ErhvervsfremmeStyrelsen), som led i opfyldelsen af laboratoriets informationspligt i henhold til gældende regler.......Denne årsberetning omfatter CGM ApS' akkrediterede virksomhed i kalenderåret 2003. Årsberetningen er udarbejdet til DANAK (Dansk Akkreditering, ErhvervsfremmeStyrelsen), som led i opfyldelsen af laboratoriets informationspligt i henhold til gældende regler....

Renal involvement in the antiphospholipid syndrome (APS)-APS nephropathy.

Science.gov (United States)

Tektonidou, Maria G

2009-06-01

Although the kidney represents a major target organ in antiphospholipid syndrome (APS), renal involvement in APS was poorly recognized until recently. The most well-recognized renal manifestations of APS are the renal artery thrombosis/stenosis, renal infarction, hypertension, renal vein thrombosis, end-stage renal disease, increased allograft vascular thrombosis, some types of glomerular disease, and a small-vessel vaso-occlusive nephropathy, recently defined as APS nephropathy. APS nephropathy was first described in primary APS patients, characterized by acute thrombotic lesions in glomeruli and/or arterioles (thrombotic microangiopathy) and chronic vascular lesions such as fibrous intimal hyperplasia of arterioles and interlobular arteries, organized thrombi with or without recanalization, and fibrous arterial and arteriolar occlusions or focal cortical atrophy. APS nephropathy was also detected in further studies including patients with systemic lupus erythematosus (SLE)-related APS and SLE/non-APS patients with positive antiphospholipid antibodies, independently of lupus nephritis. The same histologic lesions, especially thrombotic mictroangiopathy, were also observed in patients with catastrophic APS. The most frequent clinical and laboratory characteristics of APS nephropathy in all the above groups of patients are hypertension (often severe), proteinuria (ranging from mild to nephrotic range), hematuria, and acute or chronic renal insufficiency.

The development of beam current monitors in the APS

International Nuclear Information System (INIS)

Wang, X.; Lenkszus, F.; Rotela, E.

1995-01-01

The Advanced Photon Source (APS) is a third-generation 7-GeV synchrotron radiation source. The precision measurement of beam current is a challenging task in high energy accelerators, such as the APS, with a wide range of beam parameters and complicated noise, radiation, and thermal environments. The beam pulses in the APS injector and storage ring have charge ranging from 50pC to 25nC with pulse durations varying from 30ps to 30ns. A total of nine non- intercepting beam current monitors have been installed in the APS facility (excluding those in the linac) for general current measurement. In addition, several independent current monitors with specially designed redundant interlock electronics are installed for personnel safety and machine protection. This paper documents the design and development of current monitors in the APS,. discusses the commissioning experience in the past year, and presents the results of recent operations

Differentiated protection services with failure probability guarantee for workflow-based applications

Science.gov (United States)

Zhong, Yaoquan; Guo, Wei; Jin, Yaohui; Sun, Weiqiang; Hu, Weisheng

2010-12-01

A cost-effective and service-differentiated provisioning strategy is very desirable to service providers so that they can offer users satisfactory services, while optimizing network resource allocation. Providing differentiated protection services to connections for surviving link failure has been extensively studied in recent years. However, the differentiated protection services for workflow-based applications, which consist of many interdependent tasks, have scarcely been studied. This paper investigates the problem of providing differentiated services for workflow-based applications in optical grid. In this paper, we develop three differentiated protection services provisioning strategies which can provide security level guarantee and network-resource optimization for workflow-based applications. The simulation demonstrates that these heuristic algorithms provide protection cost-effectively while satisfying the applications' failure probability requirements.

Manual of plant producers and services in environmental protection. Database in the field of environmental protection

International Nuclear Information System (INIS)

Serve, C.

1992-01-01

On the basis of an enquiry, the Stuttgart Chamber of Industry and Commerce produced a database of the services offered by regional and supraregional companies in the field of environmental protection. The data are presented in this manual, classified as follows: noise protection systems; sanitation systems and services; other systems and services. (orig.) [de

Implementation of automatic protection switching in an optical cross connect

OpenAIRE

Uy, Jason

2005-01-01

Having a reliable network is a hard requirement for Telecommunication companies when deploying new networks. Service providers and enterprise customers lose a lot of money any time an interruption of internet service occurs. The SONETISDH specification specifies several different types of topology that support redundancy. An Automatic Protection Switching (APS) mechanism is specified for each topology to dictate how a network behaves in a failure event. For this project, a software implementa...

Process of upgrading the radiation protection services in R. Macedonia

International Nuclear Information System (INIS)

Nikolovska, L.

2007-01-01

The utilization of radiation to be safe, reliable, and clean and environment friendly needs sufficient resources. Sufficient sources for national infrastructure could be professionals in radiation safety, laboratory and service facilities. These facilities and services are needed for intervention, calibration and intercomparison of radiation measuring equipment, personal dosimetry, environmental monitoring, and radioactive waste management. Radiological protection services need to be exercised in a manner that provides the most benefit to licenses and to society to. It should not be too little or too much; it has to be prudent, well based, equitable, and open. And it must be relevant. Based on the analyses of national situation of applications of radiation sources and national technical and professional resources, a centralised approach of radiation services positioning in the radiation legislation has been followed. By the Act, the existing services within the Republic Institute of Public Health Protection have been organized as the Radiation Protection Centre and are defined as a professional and technical service provider. The activities of Radiation Protection Centre are fulfilled through three departments: Radiation dosimetry, Radioecology and Labour medicine department. By the Act, the waste management service has to be established through National waste storage facility for low and intermediate waste. (author)

GESCOM: system for commercial management of radiological protection services

International Nuclear Information System (INIS)

Alonso Abad, Dolores; Simon Rodriguez, Carmen; Proenza Suarez, Emma

2008-01-01

A wide range of Radiological protection services of national reach are offered by the Center for Radiation Protection and Hygiene (CPHR). The software developed enlarges the possibilities of the commercial management of these services. It contains all information generated in the interaction as much with the client as with the specialists during the process of realization of these services, impregnating them an added value and contributing to increase the quality and the efficiency of the commercial management of the organization. GESCOM has a wide group of reports which offer clear and precise information. It contains general modules such as entities, services request and services contract. It has specific modules for the most complex services: external dosimetry, calibration and/or verification of dose equipment, internal contamination and measurement of samples. (author)

Optimizing Service Protection with Model Driven

OpenAIRE

Wendpanga , Francis; Biennier , Frédérique; Merle , Philippe

2015-01-01

International audience; Enterprises are more and more involved in collabo-rative business. This leads to open and outsourcing all or part of their information system (IS) to create collaborative processes by composing business services picked in each partner IS and to take advantage of Cloud computing. Business services outsourcing and their dynamic collaboration context can bring lost of control on IS and new security risks can occur. This leads to inconsistent protec-tion allowing competito...

THE ECONOMIC APPROACH OF ECOSYSTEM SERVICES PROVIDED BY PROTECTED AREAS

Directory of Open Access Journals (Sweden)

Cirnu Maria

2015-07-01

Full Text Available As practice shows us, at the present time ecosystem services are recognized by humanity, but unfortunately are undervalued compared to their full potential. Most of planet's ecosystems are degradated by anthropic activity of humankind. It is almost impossible to say that there are no areas affected by human activity, however, the Protected Areas are a good opportunity, so the assessing of ecosystem services in Protected Areas can be a solution to the problem of economic growth. At present, there are few consistent informations on economic value of ecosystem services in Romania, on the basis of which can be adopted some sustainable financing policies of activities in Protected Areas. The premise from which we start is that a proper management of natural capital will allow biodiversity conservation and human well-being if it find appropriate economic instruments. For this reason, studies of economic research on the contribution of those ecosystem services to the communities welfare may constitute credible means for decision-makers, demonstrating the Protected Areas importance. This paper, based on the study of international and national literature, examines the state of knowledge on the economic and environmental valences of ecosystem services. The growing interest of researchers regarding the economic valuation of ecosystem services related to Protected Areas is visible through the many studies carried out at international level. Although national scientific research relating to ecosystem services is at the beginning, concerns researchers economists and ecologists have been directed toward this recess, of ecosystem services. The reason for we should assign an economic value to ecosystem services is to ensure that their value is included actively in decision-making and is not ignored because "is still available". Briefly, the paper start with an overview of the main definition of ecosystem services. From the point of economic value view, the paper

Resilience in young children involved with child protective services.

Science.gov (United States)

Sattler, Kierra M P; Font, Sarah A

2018-01-01

Child maltreatment increases the risk of poor developmental outcomes. However, some children display resilience, meaning they are high-functioning despite their adverse experiences. To date, few research studies have examined protective factors among very young maltreated children. Yet, domains of resilience, and the protective factors that promote resilience among maltreated children, are likely to differ by developmental stage. Drawing on ecological systems theory and life course theory, we examined how protective factors at multiple ecological levels across early childhood were related to social and cognitive resilience among very young children involved with child protective services. The results demonstrated that the buffering effects of protective factors varied by social or cognitive resilience and the cumulative effects of protective factors were more consistently related to later resilience than protective factors at specific time points. In addition, the influence of specific protective factors on resilience slightly varied by initial in-home or out-of-home placement. These findings have important policy and research implications for promoting optimal development among children involved in child protective services. Copyright © 2017 Elsevier Ltd. All rights reserved.

International Physical Protection Advisory Service

International Nuclear Information System (INIS)

Soo Hoo, M.S.; Ek, D.; Hageman, A.; Jenkin, T.; Price, C.; Weiss, B.

1998-01-01

Since its inception in 1996, the purpose of the International Physical Protection Advisory Service (IPPAS) has been to provide advice and assistance to International Atomic Energy Agency (IAEA) Member States on strengthening and enhancing the effectiveness of their state system of physical protection of nuclear materials and facilities. Since the protection of nuclear materials and facilities is a Member State's responsibility, participation within the IPPAS program is voluntary. At the request of a Member State, the IAEA forms a multinational IPPAS team consisting of physical protection specialists. These specialists have broad experience in physical protection system design, implementation, and regulatory oversight. The exact make-up of the team depends upon the needs of the requesting state. IPPAS missions to participating states strive to compare the domestic procedures and practices of the state against international physical protection guidelines (IAEA Information Circular 225) and internationally accepted practice. The missions utilize a top to bottom approach and begin by reviewing the legal and regulatory structure and conclude with reviews of the implementation of the state regulations and international guidelines at individual facilities. IPPAS findings are treated as IAEA Safeguards Confidential Information. To date, IPPAS missions have been concluded in Slovenia, Bulgaria, Romania, Hungary, and Poland

Center for Geometrisk Metrologi, CGM ApS

DEFF Research Database (Denmark)

De Chiffre, Leonardo

Denne årsberetning omfatter CGM ApS' akkrediterede virksomhed i kalenderåret 2002. Årsberetningen er udarbejdet til DANAK (Dansk Akkreditering, Erhvervsfremme Styrelsen), som led i opfyldelsen af laboratoriets informationspligt i henhold til gældende regler (Teknisk Forskrift Nr. TF4 af 2000...

Radiation Protection Services Division: progress report for 1992-1993

International Nuclear Information System (INIS)

Massand, O.P.; Murthy, B.K.S.

1994-01-01

This report describes the work of the Radiation Protection Services Division during 1993, for implementation of radiation safety in all institutions in India using radiation sources in medical, industrial and research applications. It gives information about personnel monitoring using photographic film and TLD badges, neutron monitoring badges, advisory and licensing services, regulation, transport of radioactive materials and periodic protection survey. About 33 publications by the staff of the Division are also listed. (author). 4 tabs

Osiguravanje međuoperabilnosti za Internet stvari: iskustvo s testiranjem CoAP protokola

OpenAIRE

Chen, Nanxing; Viho, César; Baire, Anthony; Huang, Xiaohong; Zha, Jiexi

2014-01-01

Constrained Application Protocol (CoAP) is a specialized web transfer protocol, designed for realizing interoperation with constrained networks and nodes for machine to machine applications like smart energy, building automation, etc. As an important ubiquitous application protocol for the future Internet of Things, CoAP will be potentially implemented by a wide range of smart devices to achieve cooperative services. Therefore, a high level of interoperability of CoAP implementations is cruci...

CLEARING MAGNET DESIGN FOR APS-U

Energy Technology Data Exchange (ETDEWEB)

Abliz, M.; Grimmer, J.; Jaski, Y.; Westferro, F.; Ramanathan, M.

2017-06-25

The Advanced Photon Source is in the process of developing an upgrade (APS-U) of the storage ring. The upgrade will be converting the current double bend achromat (DBA) lattice to a multi-bend achromat (MBA) lattice. In addition, the storage ring will be operated at 6 GeV and 200 mA with regular swap-out injection to keep the stored beam current constant [1]. The swap-out injection will take place with beamline shutters open. For radiation safety to ensure that no electrons can exit the storage ring, a passive method of protecting the beamline and containing the electrons inside the storage ring is proposed. A clearing magnet will be located in all beamline front ends inside the storage ring tunnel. This article will discuss the features and design of the clearing magnet scheme for APS-U.

Advances on radiation protection dosimetry research, development and services at AEOI

International Nuclear Information System (INIS)

Sohrabi, M.

1993-01-01

Radiation dosimetry is the main counterpart of an effective national radiation protection program to protect radiation workers, public and the environment against harmful effects of radiation. Research and development on radiation dosimetry are of vital needs to support national dosimetry services. The National Radiation Protection Department (NRPD) of the Atomic Energy Organization of Iran (AEOI) being a National Authority on radiation protection is also responsible for radiation dosimetry research, development and services. Some highlights of such activities at NRPD are reviewed and discussed

Effects of pictures and textual arguments in sun protection public service announcements.

Science.gov (United States)

Boer, Henk; Ter Huurne, Ellen; Taal, Erik

2006-01-01

The effect of public service announcements aimed at promoting primary prevention of skin cancer may be limited by superficial cognitive processing. The use of both pictures and textual arguments in sun protection public service announcements were evaluated for their potentially beneficial effects on judgment, cognitive processing and persuasiveness. In a 2 x 2 factorial experimental design individuals were shown public service announcements that advocated the advantages of sun protection measures in different versions in which a picture was present or not present and a textual argument was present or not present. The 159 participants were randomly assigned to one of four conditions. In each condition, participants were shown 12 different public service announcements designed according to the condition. Participants judged each public service announcement on attractiveness, credibility, clarity of communication and the required amount of reflection. After the judgment task, they completed a questionnaire to assess knowledge, perceived advantages and disadvantages of sun protection and intended use of sun protection measures. Pictures enhanced attractiveness, but diminished comprehension. Textual arguments enhanced attractiveness, credibility and comprehension. Pictures as well as textual arguments increased knowledge of sun protection measures. Pictures and textual arguments in public service announcements positively influence the individual's perception of the advantages of sun protection methods and the advantages of their adoption.

New approach for treatment of prolonged postoperative pain: APS Out-Patient Clinic.

Science.gov (United States)

Tiippana, Elina; Hamunen, Katri; Heiskanen, Tarja; Nieminen, Teija; Kalso, Eija; Kontinen, Vesa K

2016-07-01

Persistent postoperative pain (PPP) is a significant clinical problem. Several patient-related risk factors for PPP have been identified, including a previous chronic pain problem, young age, female gender and psychological vulnerability. Intra- and postoperative risk factors include surgical complications such as infections, haematoma, nerve damage and repeated surgery. As the length of hospital stay has been shortened, some patients may be discharged despite ongoing pain and insufficient analgesic medication. The challenge is to identify patients at high risk of developing PPP and to create a targeted care pathway to ensure effective and safe pain treatment especially in the subacute postoperative phase at home. This observational study describes the first two years of the Acute Pain Service Out-Patient Clinic (APS-OPC) at the Helsinki University Hospital. Patient characteristics, known risk factors, and details of treatment of PPP for the first 200 patients referred to our APS-OPC were retrospectively collected from the medical records. The APS-OPC clinic functions in close collaboration with the Multidisciplinary Pain Clinic (MPC), and the number of patients in need of physiotherapist, psychologist or psychiatrist counselling was recorded, as well as the number of patients referred to the MPC for further PPP management. Patients were referred to the APS-OPC from different surgical specialities, the two most common being thoracic and orthopaedic surgery. Seventy per cent of the patients (139/200) presented symptoms indicating neuropathic postsurgical pain. The patients had, on average, five risk factors for PPP. The median time from surgery to the first contact to the APS-OPC was two months, and the median duration of follow-up was 2.8 months (0-16 months). The median number of contacts with APS-OPC was 3 (range 1-14). Every fourth patient needed only one contact to the APS-OPC. Nineteen per cent of the patients had an appointment with the physiotherapist and 20

Tank 241-AP-106, Grab samples, 6AP-98-1, 6AP-98-2 and 6AP-98-3 Analytical results for the final report

Energy Technology Data Exchange (ETDEWEB)

FULLER, R.K.

1999-02-23

This document is the final report for tank 241-AP-106 grab samples. Three grab samples 6AP-98-1, 6AP-98-2 and 6AP-98-3 were taken from riser 1 of tank 241-AP-106 on May 28, 1998 and received by the 222-S Laboratory on May 28, 1998. Analyses were performed in accordance with the ''Compatability Grab Sampling and Analysis Plan'' (TSAP) (Sasaki, 1998) and the ''Data Quality Objectives for Tank Farms Waste Compatability Program (DQO). The analytical results are presented in the data summary report. No notification limits were exceeded. The request for sample analysis received for AP-106 indicated that the samples were polychlorinated biphenyl (PCB) suspects. The results of this analysis indicated that no PCBs were present at the Toxic Substance Control Act (TSCA) regulated limit of 50 ppm. The results and raw data for the PCB analysis are included in this document.

Tank 241-AP-106, Grab samples, 6AP-98-1, 6AP-98-2 and 6AP-98-3 Analytical results for the final report

International Nuclear Information System (INIS)

FULLER, R.K.

1999-01-01

This document is the final report for tank 241-AP-106 grab samples. Three grab samples 6AP-98-1, 6AP-98-2 and 6AP-98-3 were taken from riser 1 of tank 241-AP-106 on May 28, 1998 and received by the 222-S Laboratory on May 28, 1998. Analyses were performed in accordance with the ''Compatability Grab Sampling and Analysis Plan'' (TSAP) (Sasaki, 1998) and the ''Data Quality Objectives for Tank Farms Waste Compatability Program (DQO). The analytical results are presented in the data summary report. No notification limits were exceeded. The request for sample analysis received for AP-106 indicated that the samples were polychlorinated biphenyl (PCB) suspects. The results of this analysis indicated that no PCBs were present at the Toxic Substance Control Act (TSCA) regulated limit of 50 ppm. The results and raw data for the PCB analysis are included in this document

Thrombotic risk assessment in APS: the Global APS Score (GAPSS).

Science.gov (United States)

Sciascia, S; Bertolaccini, M L

2014-10-01

Recently, we developed a risk score for antiphospholipid syndrome (APS) (Global APS Score or GAPSS). This score derived from the combination of independent risk factors for thrombosis and pregnancy loss, taking into account the antiphospholipid antibodies (aPL) profile (criteria and non-criteria aPL), the conventional cardiovascular risk factors, and the autoimmune antibodies profile. We demonstrate that risk profile in APS can be successfully assessed, suggesting that GAPSS can be a potential quantitative marker of APS-related clinical manifestations. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Measuring the Adoption of DDoS Protection Services

NARCIS (Netherlands)

Jonker, Mattijs; Sperotto, Anna; van Rijswijk, Roland M.; Sadre, R.; Pras, Aiko

2016-01-01

Distributed Denial-of-Service (DDoS) attacks have steadily gained in popularity over the last decade, their intensity ranging from mere nuisance to severe. The increased number of attacks, combined with the loss of revenue for the targets, has given rise to a market for DDoS Protection Service (DPS)

Antiphospholipid syndrome (APS) nephropathy in catastrophic, primary, and systemic lupus erythematosus-related APS.

Science.gov (United States)

Tektonidou, Maria G; Sotsiou, Flora; Moutsopoulos, Haralampos M

2008-10-01

Renal involvement in antiphospholipid syndrome (APS) has been poorly recognized. A renal small-vessel vasculopathy, defined as APS nephropathy, has recently been observed in small series of patients with primary APS (PAPS) and systemic lupus erythematosus (SLE)-APS. We examined the renal histologic, clinical, and laboratory characteristics of different groups of patients with APS including catastrophic APS (CAPS). Our study included all CAPS (n=6), PAPS (n=8), and SLE-APS (n=23) patients with biopsy-proven renal involvement who were referred to our departments. The kidney biopsy specimens were retrospectively examined by the same renal pathologist. APS nephropathy was diagnosed as previously described. Demographic, clinical, and laboratory data were recorded. All patients with CAPS had acute and chronic renal vascular lesions compatible with diagnosis of APS nephropathy. Thrombotic microangiopathy (TMA), the acute lesion, was observed in all CAPS patients. Fibrous intimal hyperplasia of interlobular arteries (FIH) and focal cortical atrophy (FCA) were the most common chronic vascular lesions, occurring in 4 of 6 (66.7%) and 3 of 6 (50%) patients with CAPS, respectively. TMA was detected in 3 of 8 (37.5%) patients with PAPS and in 8 of 23 (35%) patients with SLE-APS, while FIH and FCA were found with similar frequencies in all 3 groups. Hypertension, proteinuria, hematuria, and renal insufficiency were the most common renal manifestations of all APS groups. Acute and chronic APS nephropathy lesions were detected in all 3 APS groups. Acute lesions were more prominent in CAPS, while chronic lesions were found with similar frequencies in all groups. Hypertension, proteinuria, hematuria, and renal insufficiency were the most common renal manifestations of all APS groups.

Learning through delivery, Westinghouse AP1000 plant construction

International Nuclear Information System (INIS)

Gorgemans, J.; Hinman, R.D.; Steuck, C.M.; Greco, P.L.

2014-01-01

The AP1000 plant, which is a 1100 MWe class pressurized water reactor with passive safety features, is designed around a conventional 2 loop, 2 steam generator primary system configuration with 2 hot legs, 4 reactor coolant pumps directly mounted in the steam generator lower head and 4 cold legs. A particular feature of AP1000 is its modular construction to minimize the time and cost of construction. Modular construction allows activities to be run in parallel, it allows more activities to be performed in a controlled factory instead of in the field, and it provides a better level of quality. The AP1000 plant design includes 106 structural modules and 52 mechanical modules. Structural modules include all penetrations for piping, cable trays, HVAC duct runs, and all reinforcement for pipe, equipment hangers, and supports. Structural modules are shipped in sub-modules to support transportation by rail or truck or barge. Mechanical modules contain equipment such as pumps, tanks, heat exchangers, air-handling units, and filters along with interconnecting pipes, valves, instruments, wiring and support services. Modular construction requires strong coordination between engineering, supply chain and construction. A total of 8 AP1000 units are currently under construction in China and in the United States. The lessons learned and best practices of each new AP1000 construction are systematically incorporated into the standard design. (A.C.)

Quality assurance programs from laboratories offering radiological protection services

International Nuclear Information System (INIS)

Marrero Garcia, M.; Prendes Alonso, M.; Jova Sed, L.; Morales Monzon, J.A.

1998-01-01

The implementation of an adequate program for quality assurance in institutions servicing radiological protection programs will become an additional tool to achieve security targets included in that program. All scientific and technical services offered by CPHR employ quality assurance systems

Development of short-form measures to assess four types of elder mistreatment: Findings from an evidence-based study of APS elder abuse substantiation decisions.

Science.gov (United States)

Beach, Scott R; Liu, Pi-Ju; DeLiema, Marguerite; Iris, Madelyn; Howe, Melissa J K; Conrad, Kendon J

2017-01-01

Improving the standardization and efficiency of adult protective services (APS) investigations is a top priority in APS practice. Using data from the Elder Abuse Decision Support System (EADSS), we developed short-form measures of four types of elder abuse: financial, emotional/psychological, physical, and neglect. The EADSS data set contains 948 elder abuse cases (age 60+) with yes/no abuse substantiation decisions for each abuse type following a 30-day investigation. Item sensitivity/specificity analyses were conducted on long-form items with the substantiation decision for each abuse type as the criterion. Validity was further tested using receiver-operator characteristic (ROC) curve analysis, correlation with long forms and internal consistency. The four resulting short-form measures, containing 36 of the 82 original items, have validity similar to the original long forms. These short forms can be used to standardize and increase efficiency of APS investigations, and may also offer researchers new options for brief elder abuse assessments.

APS Science 2006

International Nuclear Information System (INIS)

Gibson, J.M.; Fenner, R.B.; Long, G.; Borland, M.; Decker, G.

2007-01-01

In my five years as the Director of the Advanced Photon Source (APS), I have been fortunate to see major growth in the scientific impact from the APS. This year I am particularly enthusiastic about prospects for our longer-term future. Every scientific instrument must remain at the cutting edge to flourish. Our plans for the next generation of APS--an APS upgrade--got seriously in gear this year with strong encouragement from our users and sponsors. The most promising avenue that has emerged is the energy-recovery linac (ERL) (see article on page xx), for which we are beginning serious R and D. The ERL(at)APS would offer revolutionary performance, especially for x-ray imaging and ultrafast science, while not seriously disrupting the existing user base. I am very proud of our accelerator physics and engineering staff, who not only keep the current APS at the forefront, but were able to greatly impress our international Machine Advisory Committee with the quality of their work on the possible upgrade option (see page xx). As we prepare for long-term major upgrades, our plans to develop and optimize all the sectors at APS in the near future are advancing. Several new beamlines saw first light this year, including a dedicated powder diffraction beamline (11-BM), two instruments for inelastic x-ray scattering at sector 30, and the Center for Nanoscale Materials (CNM) Nanoprobe beamline at sector 26. Our partnership in the first x-ray free-electron laser (LCLS) to be built at Stanford contributes to revolutionary growth in ultrafast science (see page xx), and we are developing a pulse chirping scheme to get ps pulses at sector 7 of the APS within a year or so. In this report, you will find selected highlights of scientific research at the APS from calendar year 2006. The highlighted work covers diverse disciplines, from fundamental to applied science. In the article on page xx you can see the direct impact of APS research on technology. Several new products have emerged

APS Science 2006.

Energy Technology Data Exchange (ETDEWEB)

Gibson, J. M.; Fenner, R. B.; Long, G.; Borland, M.; Decker, G.

2007-05-24

In my five years as the Director of the Advanced Photon Source (APS), I have been fortunate to see major growth in the scientific impact from the APS. This year I am particularly enthusiastic about prospects for our longer-term future. Every scientific instrument must remain at the cutting edge to flourish. Our plans for the next generation of APS--an APS upgrade--got seriously in gear this year with strong encouragement from our users and sponsors. The most promising avenue that has emerged is the energy-recovery linac (ERL) (see article on page xx), for which we are beginning serious R&D. The ERL{at}APS would offer revolutionary performance, especially for x-ray imaging and ultrafast science, while not seriously disrupting the existing user base. I am very proud of our accelerator physics and engineering staff, who not only keep the current APS at the forefront, but were able to greatly impress our international Machine Advisory Committee with the quality of their work on the possible upgrade option (see page xx). As we prepare for long-term major upgrades, our plans to develop and optimize all the sectors at APS in the near future are advancing. Several new beamlines saw first light this year, including a dedicated powder diffraction beamline (11-BM), two instruments for inelastic x-ray scattering at sector 30, and the Center for Nanoscale Materials (CNM) Nanoprobe beamline at sector 26. Our partnership in the first x-ray free-electron laser (LCLS) to be built at Stanford contributes to revolutionary growth in ultrafast science (see page xx), and we are developing a pulse chirping scheme to get ps pulses at sector 7 of the APS within a year or so. In this report, you will find selected highlights of scientific research at the APS from calendar year 2006. The highlighted work covers diverse disciplines, from fundamental to applied science. In the article on page xx you can see the direct impact of APS research on technology. Several new products have emerged from

The provision of radiological protection services

International Nuclear Information System (INIS)

1965-01-01

This publication is a code of practice for the provision or radiological protection services for establishments in which, or in part of which, work is primarily with radiation sources. It was prepared with the help of an international panel of experts and representatives of international organizations which have an interest in this field and was promulgated by the Director General of the Agency under the authority of the Board of Governors of the Agency as a code of practice in the framework of the Agency's Safety Standards. The Board of Governors also authorized the Director General to recommend to Member States that the code of practice be taken into account in the formulation of national regulations or recommendations. The Appendix to the code contains a number of examples of the organization of radiological protection services that have been provided by the members of the panel of experts. These examples do not form a part of the code of practice, but are intended to illustrate the methods of organization which have been adopted in different countries.

Increasing the reliability, availability, and maintainability of the AP600 by design

International Nuclear Information System (INIS)

Trombola, D.; Meyer, C.

1993-01-01

The AP600 design is based on providing a safe, simple, standardized, and economically competitive design with a high degree of operability and ease of maintenance. Design features such as component selection, layout, and standardization increase the probability that targeted repair times are achieved. Design requirements from the utility industry and industry design practices have established criteria for: layout, changeout and replacement of parts and components; access for major pieces of equipment; and vehicle passage. These features coupled with a solid reliability assurance and maintenance program will help the AP600 meet its objectives for operation and maintenance. The AP600 draws on the operating experience and lessons learned from the utility community through design workshops and design review interaction, as well as operating plant data from sources several sources. Internally, the AP600 program incorporates the resources of Westinghouse NSD (Nuclear Service Division), which for decades has provided refueling, steam generator, reactor coolant pump, and other operating plant services. Since the early phases of the design process, the AP600 Program has executed a comprehensive reliability, availability, and maintainability program (RAM) which dealt primarily with assessing and improving plant availability. In conjunction with this program a Probabilistic Risk Assessment (PRA) was performed and submitted to the NRC with the Standard Safety Analysis Report (SSAR) in June 1992. This paper describes how AP600 ensures that the plant has design features to enhance reliability, availability, and maintainability. The RAM program that brings the plant through the design certification phase is described

Representation of Ecosystem Services by Terrestrial Protected Areas: Chile as a Case Study

Science.gov (United States)

Durán, América P.; Casalegno, Stefano; Marquet, Pablo A.; Gaston, Kevin J.

2013-01-01

Protected areas are increasingly considered to play a key role in the global maintenance of ecosystem processes and the ecosystem services they provide. It is thus vital to assess the extent to which existing protected area systems represent those services. Here, for the first time, we document the effectiveness of the current Chilean protected area system and its planned extensions in representing both ecosystem services (plant productivity, carbon storage and agricultural production) and biodiversity. Additionally, we evaluate the effectiveness of protected areas based on their respective management objectives. Our results show that existing protected areas in Chile do not contain an unusually high proportion of carbon storage (14.9%), agricultural production (0.2%) or biodiversity (11.8%), and also represent a low level of plant productivity (Normalized Difference Vegetation Index of 0.38). Proposed additional priority sites enhance the representation of ecosystem services and biodiversity, but not sufficiently to attain levels of representation higher than would be expected for their area of coverage. Moreover, when the species groups were assessed separately, amphibians was the only one well represented. Suggested priority sites for biodiversity conservation, without formal protection yet, was the only protected area category that over-represents carbon storage, agricultural production and biodiversity. The low representation of ecosystem services and species’ distribution ranges by the current protected area system is because these protected areas are heavily biased toward southern Chile, and contain large extents of ice and bare rock. The designation and management of proposed priority sites needs to be addressed in order to increase the representation of ecosystem services within the Chilean protected area system. PMID:24376559

AP1000{sup R} nuclear power plant safety overview for spent fuel cooling

Energy Technology Data Exchange (ETDEWEB)

Gorgemans, J.; Mulhollem, L.; Glavin, J.; Pfister, A.; Conway, L.; Schulz, T.; Oriani, L.; Cummins, E.; Winters, J. [Westinghouse Electric Company LLC, 1000 Westinghouse Drive, Cranberry Township, PA 16066 (United States)

2012-07-01

The AP1000{sup R} plant is an 1100-MWe class pressurized water reactor with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance, safety and costs. The AP1000 design uses passive features to mitigate design basis accidents. The passive safety systems are designed to function without safety-grade support systems such as AC power, component cooling water, service water or HVAC. Furthermore, these passive features 'fail safe' during a non-LOCA event such that DC power and instrumentation are not required. The AP1000 also has simple, active, defense-in-depth systems to support normal plant operations. These active systems provide the first level of defense against more probable events and they provide investment protection, reduce the demands on the passive features and support the probabilistic risk assessment. The AP1000 passive safety approach allows the plant to achieve and maintain safe shutdown in case of an accident for 72 hours without operator action, meeting the expectations provided in the U.S. Utility Requirement Document and the European Utility Requirements for passive plants. Limited operator actions are required to maintain safe conditions in the spent fuel pool via passive means. In line with the AP1000 approach to safety described above, the AP1000 plant design features multiple, diverse lines of defense to ensure spent fuel cooling can be maintained for design-basis events and beyond design-basis accidents. During normal and abnormal conditions, defense-in-depth and other systems provide highly reliable spent fuel pool cooling. They rely on off-site AC power or the on-site standby diesel generators. For unlikely design basis events with an extended loss of AC power (i.e., station blackout) or loss of heat sink or both, spent fuel cooling can still be provided indefinitely: - Passive systems, requiring minimal or no operator actions, are sufficient for at least 72 hours under all

AP1000{sup R} severe accident features and post-Fukushima considerations

Energy Technology Data Exchange (ETDEWEB)

Scobel, J. H.; Schulz, T. L.; Williams, M. G. [Westinghouse Electric Company, LLC, 1000 Westinghouse Dr., Cranberry Township, PA 16066 (United States)

2012-07-01

The AP1000{sup R} passive nuclear power plant is uniquely equipped to withstand an extended station blackout scenario such as the events following the earthquake and tsunami at Fukushima without compromising core and containment integrity. The AP1000 plant shuts down the reactor, cools the core, containment and spent fuel pool for more than 3 days using passive systems that do not require AC or DC power or operator actions. Following this passive coping period, minimal operator actions are needed to extend the operation of the passive features to 7 days using installed equipment. To provide defense-in-depth for design extension conditions, the AP1000 plant has engineered features that mitigate the effects of core damage. Engineered features retain damaged core debris within the reactor vessel as a key feature. Other aspects of the design protect containment integrity during severe accidents, including unique features of the AP1000 design relative to passive containment cooling with water and air, and hydrogen management. (authors)

Results of the AP600 advanced plant probabilistic risk assessment

International Nuclear Information System (INIS)

Bueter, T.; Sancaktar, S.; Freeland, J.

1997-01-01

The AP600 Probabilistic Risk Assessment (PRA) includes detailed models of the plant systems, including the containment and containment systems that would be used to mitigate the consequences of a severe accident. The AP600 PRA includes a level 1 analysis (core damage frequency), and a level 2 analysis (environmental consequences), an assessment of the plant vulnerability to accidents caused by fire or floods, and a seismic margins analysis. Numerous sensitivities are included in the AP600 PRA including one that assumes no credit for non-safety plant systems. The core damage frequency for the AP600 of 1.7E-07/year is small compared with other PRAs performed in the nuclear industry. The AP600 large release frequency of 1.8E-08/year is also small and shows the ability of the containment systems to prevent a large release should a severe accident occur. Analyses of potential consequences to the environment from a severe accident show that a release would be small, and that containment still provides significant protection 24 hours after an assumed accident. Sensitivity analyses show that plant risk (as measured by core damage frequency and large release frequency) is not sensitive to the reliability of operator actions. 6 refs., 1 fig., 1 tab

Protection policy for users of financial services. Conceptual basis

Directory of Open Access Journals (Sweden)

Adrián Zelaia Ulibarri

2011-12-01

Full Text Available The financial crisis has highlighted critical gaps in the protection of financial services users, both as depositors/investors as well as lenders. While the need to protect financial services users has become vital as a result of the financial crisis, lack of political action during the first three years of the crisis has caused certain scepticism. In-depth reflection is urgently needed on how to proceed with the over financing accumulated by families and firms to ensure a progressive reduction of the «systemic» risk in the least drastic manner possible.Received: 28.02.11Accepted: 29.03.11

Testing of Solar Heated Domestic Hot Water System for Solahart Scandinavia ApS

DEFF Research Database (Denmark)

Andersen, Elsa

1997-01-01

The solar heating system marketed by Solahart Scandinavia ApS was tested in the Institutes test facility for SDHWsystems. The test results are described in the report.......The solar heating system marketed by Solahart Scandinavia ApS was tested in the Institutes test facility for SDHWsystems. The test results are described in the report....

Got AP?

Science.gov (United States)

Digby, Joan

2016-01-01

Families, especially those considering sending their children to a private four-year university, need all the help they can get in funding college. Annmarie Guzy's essay "AP, Dual Enrollment, and the Survival of Honors Education" in this issue powerfully spells out the financial benefits that accrue from using AP courses to satisfy…

76 FR 70660 - Prohibition on Federal Protective Service Guard Services Contracts With Business Concerns Owned...

Science.gov (United States)

2011-11-15

...-AA55 Prohibition on Federal Protective Service Guard Services Contracts With Business Concerns Owned... redesignation of sections related to contracting with corporate expatriates and the recodification of certain public contracting laws in title 41, United States Code. DATES: Effective Date: November 15, 2011. FOR...

DESIGNING OF ELECTRONIC LIBRARIES SYSTEM OF SCIENTIFIC AND EDUCATIONAL INSTITUTIONS OF APS OF UKRAINE

Directory of Open Access Journals (Sweden)

Oleg M. Spirin

2010-08-01

Full Text Available In the article the concept of electronic library is considered, preconditions of its designing for the institutions of APS of Ukraine are investigated. The basic components, base services of electronic library and kinds of corresponding resources are defined. It is proved typical decisions for working out of electronic scientifically-educational library of APS of Ukraine.

Purification, characterisation and protective effects of polysaccharides from alfalfa on hepatocytes.

Science.gov (United States)

Wang, Shaopu; Dong, Xiaofang; Ma, Hao; Cui, Yaoming; Tong, Jianming

2014-11-04

The objective of this study was to determine the preliminary characteristics and protective effects of alfalfa polysaccharides (APS) on hepatocytes in vitro. The crude APS was purified by DEAE-cellulose and Sephadex G-100 chromatography, resulting in the four purified fractions: APS-1, APS-2, APS-3 and APS-4. The results indicated that APS-3 had higher carbohydrate and uronic acid contents and that APS-4 had a more complicated monosaccharide composition compared to the other purified fractions. The average molecular weights of APS-1, APS-2, APS-3 and APS-4 were 48,536, 6,221, 66,559 and 13,076 Da, respectively. Furthermore, APS (crude and its purified fractions) restored the activities of antioxidant enzymes and increased the total antioxidant capacity of hepatocytes subjected to H2O2-induced oxidative stress. Furthermore, APS treatment counteracted the increases in lactic dehydrogenase and malonaldehyde in the culture supernatant. These results clearly demonstrate that APS possesses a protective effect against oxidative injury in hepatocytes. Copyright © 2014 Elsevier Ltd. All rights reserved.

APS Science 2009.

Energy Technology Data Exchange (ETDEWEB)

Gibson, J. M; Mills, D. M.; Gerig, R.

2010-05-01

It is my pleasure to introduce the 2009 annual report of the Advanced Photon Source. This was a very good year for us. We operated with high reliability and availability, despite growing problems with obsolete systems, and our users produced a record output of publications. The number of user experiments increased by 14% from 2008 to more than 3600. We congratulate the recipients of the 2009 Nobel Prize in Chemistry-Venkatraman Ramakrishnan (Cambridge Institute for Medical Research), Thomas Steitz (Yale University), and Ada Yonath (Weizmann Institute) - who did a substantial amount of this work at APS beamlines. Thanks to the efforts of our users and staff, and the ongoing counsel of the APS Scientific Advisory Committee, we made major progress in advancing our planning for the upgrade of the APS (APS-U), producing a proposal that was positively reviewed. We hope to get formal approval in 2010 to begin the upgrade. With advocacy from our users and the support of our sponsor, the Office of Basic Energy Sciences in the Department of Energy (DOE) Office of Science, our operating budgets have grown to the level needed to more adequately staff our beamlines. We were also extremely fortunate to have received $7.9 M in American Recovery and Reinvestment Act ('stimulus') funding to acquire new detectors and improve several of our beamlines. The success of the new Linac Coherent Light Source at Stanford, the world's first x-ray free-electron laser, made us particularly proud since the undulators were designed and built by the APS. Among other highlights, we note that more than one-quarter of the 46 Energy Frontier Research Centers, funded competitively across the U.S. in 2009 by the DOE, included the Advanced Photon Source in their proposed work, which shows that synchrotron radiation, and the APS in particular, are central to energy research. While APS research covers everything from fundamental to applied science (reflected by the highlights in this report

Services of radiological protection: as sizing the human and material resources

International Nuclear Information System (INIS)

Rueda Guerrero, M. D.; Sierra Perler, I.; Lorenzo Perez, P.

2014-01-01

Discussion of radiological protection in the Middle Health has formed a task force to develop a technical document recommendatory to help plan and evaluate resources radiological protection services. (Author)

Is an ecosystem services-based approach developed for setting specific protection goals for plant protection products applicable to other chemicals?

Science.gov (United States)

Maltby, Lorraine; Jackson, Mathew; Whale, Graham; Brown, A Ross; Hamer, Mick; Solga, Andreas; Kabouw, Patrick; Woods, Richard; Marshall, Stuart

2017-02-15

Clearly defined protection goals specifying what to protect, where and when, are required for designing scientifically sound risk assessments and effective risk management of chemicals. Environmental protection goals specified in EU legislation are defined in general terms, resulting in uncertainty in how to achieve them. In 2010, the European Food Safety Authority (EFSA) published a framework to identify more specific protection goals based on ecosystem services potentially affected by plant protection products. But how applicable is this framework to chemicals with different emission scenarios and receptor ecosystems? Four case studies used to address this question were: (i) oil refinery waste water exposure in estuarine environments; (ii) oil dispersant exposure in aquatic environments; (iii) down the drain chemicals exposure in a wide range of ecosystems (terrestrial and aquatic); (iv) persistent organic pollutant exposure in remote (pristine) Arctic environments. A four-step process was followed to identify ecosystems and services potentially impacted by chemical emissions and to define specific protection goals. Case studies demonstrated that, in principle, the ecosystem services concept and the EFSA framework can be applied to derive specific protection goals for a broad range of chemical exposure scenarios. By identifying key habitats and ecosystem services of concern, the approach offers the potential for greater spatial and temporal resolution, together with increased environmental relevance, in chemical risk assessments. With modifications including improved clarity on terminology/definitions and further development/refinement of the key concepts, we believe the principles of the EFSA framework could provide a methodical approach to the identification and prioritization of ecosystems, ecosystem services and the service providing units that are most at risk from chemical exposure. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights

Vascular Manifestations in Antiphospholipid Syndrome (APS): Is APS a Thrombophilia or a Vasculopathy?

Science.gov (United States)

Siddique, Salma; Risse, Jessie; Canaud, Guillaume; Zuily, Stéphane

2017-09-04

Antiphospholipid antibody syndrome (APS) is characterized primarily by thrombosis and pregnancy morbidity. Chronic vascular lesions can also occur. While the underlying mechanisms of these vascular lesions are not entirely known, there have been multiple theories describing the potential process of vasculopathy in APS and the various clinical manifestations associated with it. Recently, it has been demonstrated that endothelial proliferation in kidneys can be explained by the activation of the mammalian target of rapamycin complex (mTORC) pathway by antiphospholipid antibodies (aPL). These data support the existence of an APS-related vasculopathy in different locations which can explain-in part-the different manifestations of APS. This review focuses on the various manifestations of APS as a result of APS-related vasculopathy, as well as pathophysiology, current screening, and treatment options for clinicians to be aware of.

Kepler observations of rapidly oscillating Ap, δ Scuti and γ Doradus pulsations in Ap stars

DEFF Research Database (Denmark)

Balona, Luis A.; Cunha, Margarida S.; Kurtz, Donald W.

2011-01-01

Observations of the A5p star KIC 8677585 obtained during the Kepler 10-d commissioning run with 1-min time resolution show that it is a rapidly oscillating Ap (roAp) star with several frequencies with periods near 10 min. In addition, a low frequency at 3.142 d−1 is also clearly present....... Multiperiodic γ Doradus (γ Dor) and δ Scuti (δ Sct) pulsations, never before seen in any Ap star, are present in Kepler observations of at least three other Ap stars. Since γ Dor pulsations are seen in Ap stars, it is likely that the low frequency in KIC 8677585 is also a γ Dor pulsation. The simultaneous...... presence of both γ Dor and roAp pulsations and the unexpected detection of δ Sct and γ Dor pulsations in Ap stars present new opportunities and challenges for the interpretation of these stars. Since it is easy to confuse Am and Ap stars at classification dispersions, the nature of these Ap stars...

APS SCIENCE 2016

Energy Technology Data Exchange (ETDEWEB)

Fenner, Richard B. [Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

2017-05-01

The Advanced Photon Source (APS) occupies an 80-acre site on the Argonne national laboratory campus, about 25 miles from downtown chicago, illinois. it shares the site with the center for nanoscale materials and the Advanced Protein characterization facility. for directions to Argonne, see http://www.anl.gov/directions-and-visitor-information. The APS, a national synchrotron radiation research facility operated by Argonne for the u.S. department of energy (doe) office of Science, provides this nation’s brightest high-energy x-ray beams for science. research by APS users extends from the center of the earth to outer space, from new information on combustion engines and microcircuits to new drugs and nanotechnologies whose scale is measured in billionths of a meter. The APS helps researchers illuminate answers to the challenges of our high-tech world, from developing new forms of energy, to sustaining our nation’s technological and economic competitiveness, to pushing back against the ravages of disease. research at the APS promises to have far-reaching

Optimal channel utilization and service protection in cellular communication systems

DEFF Research Database (Denmark)

Iversen, Villy Bæk

1997-01-01

In mobile communications an efficient utilization of the channels is of great importance.In this paper we consider the basic principles for obtaining the maximum utilization, and we study strategies for obtaining these limits.In general a high degree of sharing is efficient, but requires service...... protection mechanisms for protecting services and subscriber groups.We study cellular systems with overlaid cells, and the effect of overlapping cells, and we show that by dynamic channel allocation we obtain a high utilization.The models are generalizations of the Erlang-B formula, and can be evaluated...

INTERNATIONAL PRACTICE OF INSURANCE SERVICES CONSUMER PROTECTION

Directory of Open Access Journals (Sweden)

Irina P. Khominitch

2014-01-01

Full Text Available The article considers the current compensationand guarantee mechanisms of policyholders’protection in the context of reforms inregulation and supervision of insurancecompanies. Models and fi nancing sourcesof insurance services consumer protectionfunds, their features in different countries as well as order and size of compensationpayments are identified in this article.

AP Music Theory Applied

Science.gov (United States)

Spieker, Matthew H.

2016-01-01

Some American high schools include Advanced Placement (AP) Music Theory within their course offerings. Students who pass the AP exam can receive college credit either as a music or humanities credit. An AP class, however, offers music students more than future college credit; it ultimately improves musicianship skills and promotes deeper…

Exploring Demand and Provision in English Child Protection Services

OpenAIRE

Hood, Rick; Goldacre, Allie; Grant, Robert; Jones, Ray

2016-01-01

This paper presents the results of an exploratory study linking the national data-sets for all children in need and child protection services in England. The study was informed by an emerging literature on systems thinking in public services, and aimed to examine variations and patterns of response in local authorities to demand for child welfare services in their area. One hundred and fifty-two local authority census returns and other statistical indicators covering up to a thirteen-year per...

Ecosystem services-based SWOT analysis of protected areas for conservation strategies.

Science.gov (United States)

Scolozzi, Rocco; Schirpke, Uta; Morri, Elisa; D'Amato, Dalia; Santolini, Riccardo

2014-12-15

An ecosystem services-based SWOT analysis is proposed in order to identify and quantify internal and external factors supporting or threatening the conservation effectiveness of protected areas. The proposed approach concerns both the ecological and the social perspective. Strengths and weaknesses, opportunities and threats were evaluated based on 12 selected environmental and socio-economic indicators for all terrestrial Italian protected areas, belonging to the Natura 2000 network, and for their 5-km buffer area. The indicators, used as criteria within a multi-criteria assessment, include: core area, cost-distance between protected areas, changes in ecosystem services values, intensification of land use, and urbanization. The results were aggregated for three biogeographical regions, Alpine, Continental, and Mediterranean, indicating that Alpine sites have more opportunities and strengths than Continental and Mediterranean sites. The results call attention to where connectivity and land-use changes may have stronger influence on protected areas, in particular, whereas urbanization or intensification of agriculture may hamper conservation goals of protected areas. The proposed SWOT analysis provides helpful information for a multiple scale perspective and for identifying conservation priorities and for defining management strategies to assure biodiversity conservation and ecosystem services provision. Copyright © 2014 Elsevier Ltd. All rights reserved.

42 CFR 51.7 - Eligibility for protection and advocacy services.

Science.gov (United States)

2010-10-01

.... 51.7 Section 51.7 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS REQUIREMENTS APPLICABLE TO THE PROTECTION AND ADVOCACY FOR INDIVIDUALS WITH MENTAL ILLNESS PROGRAM Basic... rights. This restriction does not prevent a P&A system from representing clients in commitment or...

Workers safety in public psychiatric services: problems, laws and protections.

Science.gov (United States)

Carabellese, F; Urbano, M; Coluccia, A; Gualtieri, G

2017-01-01

The dramatic case of murder of a psychiatrist during her service in her public office (Centro di Salute Mentale of Bari-Libertà) has led the authors to reflect on the safety of workplaces, in detail of public psychiatric services. It is in the light of current legislation, represented by the Legislative Decree of April 9th, 2008 no. 81, which states the implementing rules of Law 123/2007. In particular, the Authors analyzed the criticalities of the application of this Law, with the aim of safeguarding the health and safety of the workers in all psychiatric services (nursing departments, outpatient clinics, community centers, day care centers, etc.). The Authors suggest the need to set up an articulated specific organizational system of risk assessment of psychiatric services, that can prevent and protect the workers from identified risks, and finally to ensure their active participation in prevention and protection activities, in absence of which specific profiles of responsibility would be opened up to the employers.

Management information system applied to radiation protection services

International Nuclear Information System (INIS)

Grossi, Pablo Andrade; Souza, Leonardo Soares de; Figueiredo, Geraldo Magela; Figueiredo, Arthur

2013-01-01

An effective management information system based on technology, information and people is necessary to improve the safety on all processes and operations subjected to radiation risks. The complex and multisource information flux from all radiation protection activities on nuclear organizations requires a robust tool/system to highlight the strengths and weaknesses and identify behaviors and trends on the activities requiring radiation protection programs. Those organized and processed data are useful to reach a successful management and to support the human decision-making on nuclear organization. This paper presents recent improvements on a management information system based on the radiation protection directives and regulations from Brazilian regulatory body. This radiation protection control system is applied to any radiation protection services and research institutes subjected to Brazilian nuclear regulation and is a powerful tool for continuous management, not only indicating how the health and safety activities are going, but why they are not going as well as planned showing up the critical points. (author)

Management information system applied to radiation protection services

Energy Technology Data Exchange (ETDEWEB)

Grossi, Pablo Andrade; Souza, Leonardo Soares de; Figueiredo, Geraldo Magela; Figueiredo, Arthur, E-mail: pabloag@cdtn.br, E-mail: lss@cdtn.br, E-mail: gmf@cdtn.br, E-mail: arthurqof@gmail.com [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

2013-07-01

An effective management information system based on technology, information and people is necessary to improve the safety on all processes and operations subjected to radiation risks. The complex and multisource information flux from all radiation protection activities on nuclear organizations requires a robust tool/system to highlight the strengths and weaknesses and identify behaviors and trends on the activities requiring radiation protection programs. Those organized and processed data are useful to reach a successful management and to support the human decision-making on nuclear organization. This paper presents recent improvements on a management information system based on the radiation protection directives and regulations from Brazilian regulatory body. This radiation protection control system is applied to any radiation protection services and research institutes subjected to Brazilian nuclear regulation and is a powerful tool for continuous management, not only indicating how the health and safety activities are going, but why they are not going as well as planned showing up the critical points. (author)

Hanford Radiological Protection Support Services Annual Report for 1998

Energy Technology Data Exchange (ETDEWEB)

DE Bihl; JA MacLellan; ML Johnson; RK Piper; TP Lynch

1999-05-14

During calendar year (CY) 1998, the Pacific Northwest National Laboratory (PNNL) performed its customary radiological protection support services in support of the U.S. Department of Energy (DOE) Richland Operations OffIce (RL) and the Hanford contractors. These services included: 1) external dosimetry, 2) internal dosimetry, 3) in vivo measurements, 4) radiological records, 5) instrument calibra- tion and evaluation, and 6) calibration of radiation sources traceable to the National Institute of Standards and Technology (MST). The services were provided under a number of projects as summarized here.

Citizen Review Panels for Child Protective Services: A National Profile

Science.gov (United States)

Jones, Blake L.; Royse, David

2008-01-01

Citizen Review Panels (CRPs) for Child Protective Services are groups of citizen-volunteers throughout the United States who are federally mandated to evaluate local and state child protection systems. This study presents a profile of 332 CRP members in 20 states with regards to their demographic information, length of time on the panel, and …

Theoretical studies on the electronic and optoelectronic properties of [A.2AP(w)/A*.2AP(WC)/C.2AP(w)/C*.2AP(WC)/C.A(w)/C*.A(WC)]-Au8 mismatch nucleobase complexes

Science.gov (United States)

Srivastava, Ruby

2018-01-01

The electronic and optoelectronic properties of [A.2AP(w)/A*.2AP(WC)/C.2AP(w)/C*.2AP(WC)/C.A(w)/ C*.A(WC)]-Au8 metal-mismatch nucleobase complexes are investigated by means of density functional theory and time-dependent methods. We selected these mispairs as 2-aminopurine (2AP) produces incorporation errors when binding with cytosine (C) into the wobble (w) C.2AP(w) mispair, and is tautomerised into Watson-Crick (WC)-like base mispair C*.2AP(WC) and less effectively produces A.2AP(w)/A*.2AP(WC) mispairs. The vertical ionisation potential, vertical electron affinity, hardness and electrophilicity index of these complexes have also been discussed. The modifications of energy levels and charge density distributions of the frontier orbitals are also analysed. The absorption spectra of these complexes lie in the visible region, which suggests their application in fluorescent-bio imaging. The mechanism of cooperativity effect is studied by molecular orbital potential (MEP), atoms-in-molecules (AIM) and natural bond orbital analyses. Most metalated pairs have smaller HOMO-LUMO band gaps than the isolated mismatch nucleobases which suggest interesting consequences for electron transfer through DNA duplexes.

A Strategy toward Collaborative Filter Recommended Location Service for Privacy Protection

Science.gov (United States)

Wang, Peng; Yang, Jing; Zhang, Jianpei

2018-01-01

A new collaborative filtered recommendation strategy was proposed for existing privacy and security issues in location services. In this strategy, every user establishes his/her own position profiles according to their daily position data, which is preprocessed using a density clustering method. Then, density prioritization was used to choose similar user groups as service request responders and the neighboring users in the chosen groups recommended appropriate location services using a collaborative filter recommendation algorithm. The two filter algorithms based on position profile similarity and position point similarity measures were designed in the recommendation, respectively. At the same time, the homomorphic encryption method was used to transfer location data for effective protection of privacy and security. A real location dataset was applied to test the proposed strategy and the results showed that the strategy provides better location service and protects users’ privacy. PMID:29751670

A Strategy toward Collaborative Filter Recommended Location Service for Privacy Protection.

Science.gov (United States)

Wang, Peng; Yang, Jing; Zhang, Jianpei

2018-05-11

A new collaborative filtered recommendation strategy was proposed for existing privacy and security issues in location services. In this strategy, every user establishes his/her own position profiles according to their daily position data, which is preprocessed using a density clustering method. Then, density prioritization was used to choose similar user groups as service request responders and the neighboring users in the chosen groups recommended appropriate location services using a collaborative filter recommendation algorithm. The two filter algorithms based on position profile similarity and position point similarity measures were designed in the recommendation, respectively. At the same time, the homomorphic encryption method was used to transfer location data for effective protection of privacy and security. A real location dataset was applied to test the proposed strategy and the results showed that the strategy provides better location service and protects users' privacy.

Dynamic Analysis of AP1000 Shield Building Considering Fluid and Structure Interaction Effects

Directory of Open Access Journals (Sweden)

Qiang Xu

2016-02-01

Full Text Available The shield building of AP1000 was designed to protect the steel containment vessel of the nuclear reactor. Therefore, the safety and integrity must be ensured during the plant life in any conditions such as an earthquake. The aim of this paper is to study the effect of water in the water tank on the response of the AP1000 shield building when subjected to three-dimensional seismic ground acceleration. The smoothed particle hydrodynamics method (SPH and finite element method (FEM coupling method is used to numerically simulate the fluid and structure interaction (FSI between water in the water tank and the AP1000 shield building. Then the grid convergence of FEM and SPH for the AP1000 shield building is analyzed. Next the modal analysis of the AP1000 shield building with various water levels (WLs in the water tank is taken. Meanwhile, the pressure due to sloshing and oscillation of the water in the gravity drain water tank is studied. The influences of the height of water in the water tank on the time history of acceleration of the AP1000 shield building are discussed, as well as the distributions of amplification, acceleration, displacement, and stresses of the AP1000 shield building. Research on the relationship between the WLs in the water tank and the response spectrums of the structure are also taken. The results show that the high WL in the water tank can limit the vibration of the AP1000 shield building and can more efficiently dissipate the kinetic energy of the AP1000 shield building by fluid-structure interaction.

MDEP AP1000WG Design-Specific Common Position CP-AP1000WG-02. Common position addressing Fukushima Daiichi NPP accident-related issues

International Nuclear Information System (INIS)

2016-09-01

A severe accident involving several units took place in Japan at Fukushima Daiichi nuclear power plant (NPP) in March 2011. The immediate cause of the accident was an earthquake followed by a tsunami coupled with inadequate provisions against the consequences of such events in the design. Opportunities to improve protection against a realistic design basis tsunami had not been taken. As a consequence of the tsunami, safety equipment and the related safety functions were lost at the plant, leading to core damage in three units and subsequently to large radioactive release. Several studies have already been performed to better understand the accident progression and detailed technical studies are still in progress in Japan and elsewhere. In the meantime, on-going studies on the behaviour of nuclear power plants in very severe situations, similar to Fukushima Daiichi, seek to identify potential vulnerabilities in plant design and operation; to suggest reasonably practicable upgrades; or to recommend enhanced regulatory requirements and guidance to address such situations. Likewise, agencies around the world that are responsible for regulating the design, construction and operation of AP1000 R plants are engaged in similar activities. The MDEP AP1000 R Working Group (AP1000 WG) members consist of members from Canada, China, the United Kingdom and the United States. Since the regulatory review of their AP1000 R applications have not been completed by all of these Countries yet, this paper identifies common preliminary approaches to address potential safety improvements for AP1000 R plants as related to lessons learned from the Fukushima Daiichi accident or Fukushima Daiichi-related issues. In seeking common position, regulators will provide input to this paper to reflect their safety conclusions regarding the AP1000 R design and how the design could be enhanced to address Fukushima Daiichi issues. The common preliminary approaches are organized into five sections

Tank 241-AP-107, grab samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 analytical results for the final report

International Nuclear Information System (INIS)

Steen, F.H.

1997-01-01

This document is the final report for tank 241-AP-107 grab samples. Three grab samples were collected from riser 1 on September 11, 1997. Analyses were performed on samples 7AP-97-1, 7AP-97-2 and 7AP-97-3 in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1997) and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Rev. 1: Fowler, 1995; Rev. 2: Mulkey and Nuier, 1997). The analytical results are presented in the data summary report (Table 1). A notification was made to East Tank Farms Operations concerning low hydroxide in the tank and a hydroxide (caustic) demand analysis was requested. The request for sample analysis (RSA) (Attachment 2) received for AP-107 indicated that the samples were polychlorinated biphenyl (PCB) suspects. Therefore, prior to performing the requested analyses, aliquots were made to perform PCB analysis in accordance with the 222-S Laboratory administrative procedure, LAP-101-100. The results of this analysis indicated that no PCBs were present at 50 ppm and analysis proceeded as non-PCB samples. The results and raw data for the PCB analysis will be included in a revision to this document. The sample breakdown diagrams (Attachment 1) are provided as a cross-reference for relating the tank farm customer identification numbers with the 222-S Laboratory sample numbers and the portion of sample analyzed

ELECTROCHEMICAL CORROSION TESTING OF TANKS 241-AN-102 & 241-AP-107 & 241-AP-108 IN SUPPORT OF ULTRASONIC TESTING

Energy Technology Data Exchange (ETDEWEB)

WYRWAS RB; DUNCAN JB

2008-11-20

This report presents the results of the corrosion rates that were measured using electrochemical methods for tanks 241-AN-102 (AN-102), 241-AP-107 (AP 107), and 241-AP-108 (AP-108) performed under test plant RPP-PLAN-38215. The steel used as materials of construction for AN and AP tank farms was A537 Class 1. Test coupons of A537 Class 1 carbon steel were used for corrosion testing in the AN-107, AP-107, and AP-108 tank waste. Supernate will be tested from AN-102, AP-107, and Ap-108. Saltcake testing was performed on AP-108 only.

Radiation effects on active pixel sensors (APS); Effets de l'irradiation sur les capteurs a pixels actifs (APS)

Energy Technology Data Exchange (ETDEWEB)

Cohen, M; David, J P [ONERA-CERT/, 31 - Toulouse (France)

1999-07-01

Active pixel sensor (APS) is a new generation of image sensors which presents several advantages relatively to charge coupled devices (CCDs) particularly for space applications (APS requires only 1 voltage to operate which reduces considerably current consumption). Irradiation was performed using {sup 60}Co gamma radiation at room temperature and at a dose rate of 150 Gy(Si)/h. 2 types of APS have been tested: photodiode-APS and photoMOS-APS. The results show that photoMOS-APS is more sensitive to radiation effects than photodiode-APS. Important parameters of image sensors like dark currents increase sharply with dose levels. Nevertheless photodiode-APS sensitivity is one hundred time lower than photoMOS-APS sensitivity.

Interagency Collaboration between Child Protection and Mental Health Services: Practices, Attitudes and Barriers

Science.gov (United States)

Darlington, Yvonne; Feeney, Judith A.; Rixon, Kylie

2005-01-01

Objective: The aim of this paper is to examine some of the factors that facilitate and hinder interagency collaboration between child protection services and mental health services in cases where there is a parent with a mental illness and there are protection concerns for the child(ren). The paper reports on agency practices, worker attitudes and…

Clinical manifestations of antiphospholipid syndrome (APS) with and without antiphospholipid antibodies (the so-called 'seronegative APS').

Science.gov (United States)

Rodriguez-Garcia, Jose Luis; Bertolaccini, Maria Laura; Cuadrado, Maria Jose; Sanna, Giovanni; Ateka-Barrutia, Oier; Khamashta, Munther A

2012-02-01

Although the medical literature currently provides a growing number of isolated case reports of patients with clinically well-defined antiphospholipid syndrome (APS) and persistently negative antiphospholipid antibodies (aPL), there are no studies including a series of patients addressing the clinical features of this condition. The authors assessed clinical manifestations of APS in 154 patients: 87 patients with seropositive APS and 67 patients with thrombosis and/or pregnancy morbidity persistently negative for aPL and presenting with at least two additional non-criteria manifestations of APS (the so-called 'seronegative APS', SN-APS). Patients were interviewed at the time of recruitment, and a retrospective file review was carried out. There were no significant differences in the frequency of thrombotic events or obstetric morbidity in patients with SN-APS versus patients with seropositive APS: deep vein thrombosis (31.4% vs 31.0%), pulmonary embolism (23.8% vs 28.7%), stroke (14.9% vs 17.2%), transient ischaemic attack (11.9% vs 10.3%), early spontaneous abortions (67.1% vs 52.1%), stillbirths (62.5% vs 59.4%), prematurity (28.1% vs 21.7%) or pre-eclampsia (28.1% vs 23.1%). Classic and SN-APS patients show similar clinical profiles. The results suggest that clinical management in patients with APS should not be based only on the presence of conventional aPL.

Permanent education that approaches radiation protection in hemodynamic service

International Nuclear Information System (INIS)

Flor, Rita de Cassia; Anjos, Djeniffer Valdirene dos

2011-01-01

In the hemodynamic services that apply ionizing radiation yet exist the necessity of capacitation of workers for actuation in those areas. So, this qualitative study performed in a hemodynamic service at Sao Jose, Santa Catarina, Brazil, had the objective to analyse how are developed the permanent education programs and the real necessity of workers. The results have shown that the workers are longing for their qualification and formation, as generally they are admitted with not any qualification for those services. So, the workers that realize the on duty hemodynamic service praxis must do it in a conscious manner and the E P is a way for to adopt good practice in radiological protection

The protection of financial services users: The case of insurance companies and investment funds

Directory of Open Access Journals (Sweden)

Njegomir Vladimir

2012-01-01

Full Text Available The users of financial services generally do not have the required expertise that they need to process the available financial information when they make financial and investment decisions, and as such they represent a sensitive category of financial market participants, which may intentionally or unintentionally be exposed to manipulation. If the beneficiaries do not have relevant and accurate information, the relationship between the provider and the service user is characterized with information asymmetry, and because of these reasons adequate regulatory instruments are necessary in order to protect the interests of financial services users. In the financial services sector, the development of a long-term successful relationship between providers and users of services should be based on mutual trust and users' feel that they have received a value for the price paid. The aim of the paper is to highlight the modern ways of improving the protection of the interests of consumers of financial services provided by insurance companies and investment funds. The paper analyses the reasons for protection of consumers of financial services, specifics of insurance as financial service, the importance of trust as a key factor for the attraction of service users and the basic principles of operation of investment funds in the developed and the domestic financial market are compared. The particular attention is given to insurance companies and investment funds in terms of regulatory and other mechanisms of governments that are related to the protection of insureds and investment funds investors.

A Strategy toward Collaborative Filter Recommended Location Service for Privacy Protection

Directory of Open Access Journals (Sweden)

Peng Wang

2018-05-01

Full Text Available A new collaborative filtered recommendation strategy was proposed for existing privacy and security issues in location services. In this strategy, every user establishes his/her own position profiles according to their daily position data, which is preprocessed using a density clustering method. Then, density prioritization was used to choose similar user groups as service request responders and the neighboring users in the chosen groups recommended appropriate location services using a collaborative filter recommendation algorithm. The two filter algorithms based on position profile similarity and position point similarity measures were designed in the recommendation, respectively. At the same time, the homomorphic encryption method was used to transfer location data for effective protection of privacy and security. A real location dataset was applied to test the proposed strategy and the results showed that the strategy provides better location service and protects users’ privacy.

HPV16 E6 and E6AP differentially cooperate to stimulate or augment Wnt signaling

International Nuclear Information System (INIS)

Sominsky, Sophia; Kuslansky, Yael; Shapiro, Beny; Jackman, Anna; Haupt, Ygal; Rosin-Arbesfeld, Rina; Sherman, Levana

2014-01-01

The present study investigated the roles of E6 and E6AP in the Wnt pathway. We showed that E6 levels are markedly reduced in cells in which Wnt signaling is activated. Coexpression of wild-type or mutant E6AP (C820A) in Wnt-activated cells stabilized E6 and enhanced Wnt/β-catenin/TCF transcription. Expression of E6AP alone in nonstimulated cells elevated β-catenin level, promoted its nuclear accumulation, and activated β-catenin/TCF transcription. A knockdown of E6AP lowered β-catenin levels. Coexpression with E6 intensified the activities of E6AP. Further experiments proved that E6AP/E6 stabilize β-catenin by protecting it from proteasomal degradation. This function was dependent on the catalytic activity of E6AP, the kinase activity of GSK3β and the susceptibility of β-catenin to GSK3β phosphorylation. Thus, this study identified E6AP as a novel regulator of the Wnt signaling pathway, capable of cooperating with E6 in stimulating or augmenting Wnt/β-catenin signaling, thereby possibly contributing to HPV carcinogenesis. - Highlights: • The roles of E6 and E6AP in the Wnt pathway were investigated. • E6AP stabilizes E6 and enhances E6 activity in augmentation of Wnt signaling. • E6AP cooperates with E6 to stabilize β-catenin and stimulate Wnt/β-catenin signaling. • E6AP and E6 act through different mechanisms to augment or stimulate Wnt signaling

HPV16 E6 and E6AP differentially cooperate to stimulate or augment Wnt signaling

Energy Technology Data Exchange (ETDEWEB)

Sominsky, Sophia, E-mail: sophia.tab@gmail.com [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel); Kuslansky, Yael, E-mail: ykuslansky@gmail.com [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel); Shapiro, Beny, E-mail: benyshap@gmail.com [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel); Jackman, Anna, E-mail: jackman@post.tau.ac.il [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel); Haupt, Ygal, E-mail: ygal.haupt@petermac.org [Research Division, The Peter MacCallum Cancer Centre, East Melbourne (Australia); Rosin-Arbesfeld, Rina, E-mail: arina@post.tau.ac.il [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel); Sherman, Levana, E-mail: lsherman@post.tau.ac.il [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel)

2014-11-15

The present study investigated the roles of E6 and E6AP in the Wnt pathway. We showed that E6 levels are markedly reduced in cells in which Wnt signaling is activated. Coexpression of wild-type or mutant E6AP (C820A) in Wnt-activated cells stabilized E6 and enhanced Wnt/β-catenin/TCF transcription. Expression of E6AP alone in nonstimulated cells elevated β-catenin level, promoted its nuclear accumulation, and activated β-catenin/TCF transcription. A knockdown of E6AP lowered β-catenin levels. Coexpression with E6 intensified the activities of E6AP. Further experiments proved that E6AP/E6 stabilize β-catenin by protecting it from proteasomal degradation. This function was dependent on the catalytic activity of E6AP, the kinase activity of GSK3β and the susceptibility of β-catenin to GSK3β phosphorylation. Thus, this study identified E6AP as a novel regulator of the Wnt signaling pathway, capable of cooperating with E6 in stimulating or augmenting Wnt/β-catenin signaling, thereby possibly contributing to HPV carcinogenesis. - Highlights: • The roles of E6 and E6AP in the Wnt pathway were investigated. • E6AP stabilizes E6 and enhances E6 activity in augmentation of Wnt signaling. • E6AP cooperates with E6 to stabilize β-catenin and stimulate Wnt/β-catenin signaling. • E6AP and E6 act through different mechanisms to augment or stimulate Wnt signaling.

Prevention & treatment of obstetrical complications in APS: Is hydroxychloroquine the Holy Grail we are looking for?

Science.gov (United States)

Meroni, Pier Luigi

2016-12-01

Pregnancy morbidity is part of the clinical spectrum of the anti-phospholipid syndrome (APS), with an important social and economical cost. Antiplatelet and anticoagulant agents are effective in preventing the clinical manifestations in the majority of the patients. However, a consistent proportion of the pregnant women present recurrences in spite of the standard therapy. Observational studies and anecdotal reports raised the issue of additional therapeutic strategies in these refractory cases. Among these, anti-malarials (AMs) and in particular hydroxychloroquine (HCQ) are becoming more and more popular in APS as well as in other systemic autoimmune rheumatic conditions. AMs display a pleiotropic activity spanning from immunomodulation effect to anti-inflammatory and anti-thrombotic activities, all of which potentially useful in APS. The well-known safety of HCQ in pregnancy encouraged its use in pregnant women with autoimmune rheumatic disorders including APS and observational reports suggested a protective effect on obstetrical recurrences. Since thrombosis does not seem to be the main pathogenic mechanism in obstetric APS, effectiveness of the treatment with HCQ should be related to other pharmacological effects rather than to the anti-platelet or anti-thrombotic activity of the molecule. Experimental models showed that HCQ may restore some defective biological functions induced by anti-phospholipid antibodies (aPL) on trophoblasts and a recent study reported a protective effect on in vivo aPL-mediated placental and foetal neurodevelopmental abnormalities. Although the rational behind the use of HCQ in obstetric APS is sound, the evidence from the real life is not conclusive and a critical appraisal through clinical trials is mandatory. Copyright © 2016. Published by Elsevier Ltd.

Social media activism and Egyptians' use of social media to combat sexual violence: an HiAP case study.

Science.gov (United States)

Peuchaud, Sheila

2014-06-01

This paper represents a case study of how social media activists have harnessed the power of Facebook, Twitter and mobile phone networks to address sexual harassment in Egypt. HarassMap plots reports of sexual harassment on a Google Map and informs victims of support services. Tahrir Bodyguard and Operation Anti-Sexual Harassment (OpAntiSH) protect female protestors who have been vulnerable to sexual aggression at the hands of unruly mobs and by agents of the state. Activists have access to an Android app called 'I'm Getting Arrested' or 'Byt2ebed 3alia' in Egyptian Arabic. The app sends the time and GPS coordinates of an arrest to family, fellow activists, legal counsel and social media outlets. The hope is the initiatives described in this paper could inspire public health ministries and activist NGOs to incorporate crowdsourcing social media applications in the spirit of health in all policies (HiAP). To that end, this paper will begin by defining social media activism from the perspective of the communications discipline. This paper will then demonstrate the significance of sexual harassment as a public health issue, and describe several social media efforts to document incidents and protect victims. The paper will conclude with discussion regarding how these innovations could be integrated into the HiAP approach. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Electrophoretic deposition of hybrid coatings on aluminum alloy by combining 3-aminopropyltrimethoxysilan to silicon–zirconium sol solutions for corrosion protection

Energy Technology Data Exchange (ETDEWEB)

Yu, Mei; Xue, Bing; Liu, Jianhua, E-mail: yumei@buaa.edu.cn; Li, Songmei; Zhang, You

2015-09-01

Electrophoretic deposition (EPD) silicon–zirconium organic–inorganic hybrid coatings were applied on LC4 aluminum alloy for corrosion protection. 3-Glycidoxypropyl-trimethoxysilane (GTMS) and Zirconium (IV) n-propoxide (TPOZ) were used as precursors. 3-Aminopropyl-trimethoxysilane (APS) was added to enhance the corrosion protective performance of the coatings. Scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR) were employed to characterize morphology, microstructure and component. The results show that the addition of APS leads to the enhanced migration and deposition of positively charged colloidal particles on the surface of metal substrate, which results in the thickness increasing of coatings. However, loading an excessive amount of APS gives a heterogeneous coating surface. The corrosion protective performance of coatings were measured by electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization. The results indicate that the addition of APS improves corrosion protective performance of coatings. The optimal addition content of APS is about 15%. The 15% APS coating is uniform and dense, as well as has good corrosion protective performance. The impedance value (1.58 × 10{sup 5} Ω·cm{sup 2}, at the lowest frequency) of 15% APS coating is half order of magnitude higher than that of coating without APS, and 15% APS coating always keeps the best corrosion protective performance with prolonged immersion time. This kind of coating is identified with “double-structure” properties based on the analysis of EIS and potentiodynamic polarization. Furthermore, the equivalent circuit results indicate that the intermediate oxide layer plays a main role in corrosion protection. - Highlights: • Electrophoretic deposition hybrid coatings are prepared on LC4 aluminum alloy. • 3-Aminopropyl-trimethoxysilane (APS) enhances the corrosion protective performance. • The

Electrophoretic deposition of hybrid coatings on aluminum alloy by combining 3-aminopropyltrimethoxysilan to silicon–zirconium sol solutions for corrosion protection

International Nuclear Information System (INIS)

Yu, Mei; Xue, Bing; Liu, Jianhua; Li, Songmei; Zhang, You

2015-01-01

Electrophoretic deposition (EPD) silicon–zirconium organic–inorganic hybrid coatings were applied on LC4 aluminum alloy for corrosion protection. 3-Glycidoxypropyl-trimethoxysilane (GTMS) and Zirconium (IV) n-propoxide (TPOZ) were used as precursors. 3-Aminopropyl-trimethoxysilane (APS) was added to enhance the corrosion protective performance of the coatings. Scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR) were employed to characterize morphology, microstructure and component. The results show that the addition of APS leads to the enhanced migration and deposition of positively charged colloidal particles on the surface of metal substrate, which results in the thickness increasing of coatings. However, loading an excessive amount of APS gives a heterogeneous coating surface. The corrosion protective performance of coatings were measured by electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization. The results indicate that the addition of APS improves corrosion protective performance of coatings. The optimal addition content of APS is about 15%. The 15% APS coating is uniform and dense, as well as has good corrosion protective performance. The impedance value (1.58 × 10 5 Ω·cm 2 , at the lowest frequency) of 15% APS coating is half order of magnitude higher than that of coating without APS, and 15% APS coating always keeps the best corrosion protective performance with prolonged immersion time. This kind of coating is identified with “double-structure” properties based on the analysis of EIS and potentiodynamic polarization. Furthermore, the equivalent circuit results indicate that the intermediate oxide layer plays a main role in corrosion protection. - Highlights: • Electrophoretic deposition hybrid coatings are prepared on LC4 aluminum alloy. • 3-Aminopropyl-trimethoxysilane (APS) enhances the corrosion protective performance. • The coating

76 FR 42140 - Public Availability of the Merit Systems Protection Board's FY 2010 Service Contract Inventory

Science.gov (United States)

2011-07-18

... MERIT SYSTEMS PROTECTION BOARD Public Availability of the Merit Systems Protection Board's FY 2010 Service Contract Inventory AGENCY: Merit Systems Protection Board. ACTION: Notice. SUMMARY: The Merit.../service-contract-inventories-guidance-11052010.pdf . The MSPB's inventory is posted on its Web site at...

Radiation effects on active pixel sensors (APS)

International Nuclear Information System (INIS)

Cohen, M.; David, J.P.

1999-01-01

Active pixel sensor (APS) is a new generation of image sensors which presents several advantages relatively to charge coupled devices (CCDs) particularly for space applications (APS requires only 1 voltage to operate which reduces considerably current consumption). Irradiation was performed using 60 Co gamma radiation at room temperature and at a dose rate of 150 Gy(Si)/h. 2 types of APS have been tested: photodiode-APS and photoMOS-APS. The results show that photoMOS-APS is more sensitive to radiation effects than photodiode-APS. Important parameters of image sensors like dark currents increase sharply with dose levels. Nevertheless photodiode-APS sensitivity is one hundred time lower than photoMOS-APS sensitivity

Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations (II): thrombocytopenia and skin manifestations.

Science.gov (United States)

Cervera, R; Tektonidou, M G; Espinosa, G; Cabral, A R; González, E B; Erkan, D; Vadya, S; Adrogué, H E; Solomon, M; Zandman-Goddard, G; Shoenfeld, Y

2011-02-01

The objectives of the 'Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations' were to assess the clinical utility of the international consensus statement on classification criteria and treatment guidelines for the catastrophic APS, to identify and grade the studies that analyze the relationship between the antiphospholipid antibodies and the non-criteria APS manifestations, and to present the current evidence regarding the accuracy of these non-criteria APS manifestations for the detection of patients with APS. This article summarizes the studies analyzed on thrombocytopenia and skin manifestations, and presents the recommendations elaborated by the Task Force after this analysis.

International Physical Protection Advisory Service (IPPAS) Guidelines

International Nuclear Information System (INIS)

2014-01-01

The International Physical Protection Advisory Service (IPPAS) was established by the IAEA in 1995 and is a fundamental part of the IAEA’s efforts to assist States, upon request, to establish and maintain an effective national nuclear security regime to protect against the unauthorized removal of nuclear and other radioactive material, and against the sabotage of nuclear and other associated facilities, as well as material during transport, while recognizing that the ultimate responsibility for physical protection lies with the State. IPPAS provides peer review on implementing relevant international instruments, in particular the Convention on the Physical Protection of Nuclear Material (CPPNM), together with the 2005 Amendment, and on implementing the IAEA Nuclear Security Series of guidance publications, in particular Fundamentals and Recommendations. IPPAS missions compare (insofar as this is possible) the procedures and practices employed by a State with the obligations specified under the CPPNM and the 2005 Amendment, as well as with the existing international consensus guidelines provided in relevant IAEA Nuclear Security Series publications. Since 1996, 63 IPPAS missions have been conducted in 40 countries, including 15 follow-up missions, as well as the recent mission to the IAEA Office of Safeguards Analytical Services laboratories, in Seibersdorf. More than 140 experts from 34 Member States have participated in the conduct of IPPAS missions as IPPAS team members or team leaders. The updated IPPAS guidelines reflect a modular approach to make them more flexible and responsive to the needs of States. The modular approach is an innovation of great value, ensuring the degree of flexibility required to fit individual national contexts, practices and objectives as expressed by the requesting States. In particular, it also offers States the opportunity to expand the scope of a requested IPPAS mission to embrace its nuclear security regime for the protection of

Radiation protection instrumentation at the Andalusian health service

International Nuclear Information System (INIS)

Herrador Cordoba, M.; Garcia Rotllan, J.

1997-01-01

In Andalusia the contributions of radiological risks in the nuclear industry and of natural radiation are small and the same holds for medical applications of individuals and research. The performance models in radiation protection is monitored by the Andalusian Health Service through the public health institutions. This short communication describes the model and results obtained

Radiation effects on active pixel sensors (APS); Effets de l'irradiation sur les capteurs a pixels actifs (APS)

Energy Technology Data Exchange (ETDEWEB)

Cohen, M.; David, J.P. [ONERA-CERT/, 31 - Toulouse (France)

1999-07-01

Active pixel sensor (APS) is a new generation of image sensors which presents several advantages relatively to charge coupled devices (CCDs) particularly for space applications (APS requires only 1 voltage to operate which reduces considerably current consumption). Irradiation was performed using {sup 60}Co gamma radiation at room temperature and at a dose rate of 150 Gy(Si)/h. 2 types of APS have been tested: photodiode-APS and photoMOS-APS. The results show that photoMOS-APS is more sensitive to radiation effects than photodiode-APS. Important parameters of image sensors like dark currents increase sharply with dose levels. Nevertheless photodiode-APS sensitivity is one hundred time lower than photoMOS-APS sensitivity.

Radiological protection of service and civilian personnel

International Nuclear Information System (INIS)

1990-01-01

Since the United Kingdom's defence nuclear industry was founded in the late 1940s, Service and civilian personnel have been exposed to ionising radiation. During the last forty years, as knowledge about the effects of radiation exposure has grown, concern to ensure adequate protection against exposure has also increased,. As part of our continuing scrutiny of the Ministry of Defence (MoD), we have undertaken a short inquiry to examine MoD's current and future policy and practice on radiological protection. The principal work involving exposure of Service and civilian personnel to significant levels of radiation falls into two discrete areas: the nuclear weapons programme and the nuclear propulsion programme. The nuclear weapons programme involves research, the production of nuclear warheads and their deployment with Her Majesty's Forces. The nuclear propulsion programme involves research, production, operation, refitting and decommissioning of pressurised water reactors as a source of propulsion power in Royal Navy submarines. These two nuclear programmes are not the only sources of ionising radiation within MoD's responsibility: it also arises from research, non-destructive testing and medical applications, most notably conventional radiography. In this Report we have concentrated upon ionising radiation arising from the two defence nuclear programmes. (author)

Center for Geometrisk Metrologi CGM ApS, Årsberetning 2001 til DANAK

DEFF Research Database (Denmark)

De Chiffre, Leonardo

Denne årsberetning omfatter CGM ApS' akkrediterede virksomhed i kalenderåret 2001. Årsberetningen er udarbejdet til DANAK (Dansk Akkreditering, Erhvervsfremme Styrelsen), som led i opfyldelsen af laboratoriets informationspligt i henhold til gældende regler (Teknisk Forskrift Nr. TF4 af 2000...

Thermal Decomposition Characteristics of Orthorhombic Ammonium Perchlorate (o-AP) and an 0-AP/HTPB-Based Propellant

International Nuclear Information System (INIS)

BEHRENS JR., RICHARD; MINIER, LEANNA M.G.

1999-01-01

A study to characterize the low-temperature reactive processes for o-AP and an AP/HTPB-based propellant (class 1.3) is being conducted in the laboratory using the techniques of simultaneous thermogravimetric modulated beam mass spectrometry (STMBMS) and scanning electron microscopy (SEM). The results presented in this paper are a follow up of the previous work that showed the overall decomposition to be complex and controlled by both physical and chemical processes. The decomposition is characterized by the occurrence of one major event that consumes up to(approx)35% of the AP, depending upon particle size, and leaves behind a porous agglomerate of AP. The major gaseous products released during this event include H(sub 2)O, O(sub 2), Cl(sub 2), N(sub 2)O and HCl. The recent efforts provide further insight into the decomposition processes for o-AP. The temporal behaviors of the gas formation rates (GFRs) for the products indicate that the major decomposition event consists of three chemical channels. The first and third channels are affected by the pressure in the reaction cell and occur at the surface or in the gas phase above the surface of the AP particles. The second channel is not affected by pressure and accounts for the solid-phase reactions characteristic of o-AP. The third channel involves the interactions of the decomposition products with the surface of the AP. SEM images of partially decomposed o-AP provide insight to how the morphology changes as the decomposition progresses. A conceptual model has been developed, based upon the STMBMS and SEM results, that provides a basic description of the processes. The thermal decomposition characteristics of the propellant are evaluated from the identities of the products and the temporal behaviors of their GFRs. First, the volatile components in the propellant evolve from the propellant as it is heated. Second, the hot AP (and HClO(sub 4)) at the AP-binder interface oxidize the binder through reactions that

Comparative analysis between radiographic views for knee osteoarthrosis (bipedal AP versus monopedal AP

Directory of Open Access Journals (Sweden)

Rodrigo Pires e Albuquerque

2013-08-01

Full Text Available OBJECTIVE: A comparative analysis by applying the criteria of the original classification Ahlbäck in the anteroposterior (AP bipedal knee in extension and anteroposterior (AP monopodal knee in symptomatic knee arthrosis. With this analysis we intend to observe the agreement, any advantage or difference between the incidence and degree of joint involvement between the orthopedic surgeons and radiologists with the referring physician. METHODS: From January 2012 to March 2012, was a prospective study of 60 symptomatic arthrosis knees (60 patients, clinically selected group of outpatient knee and radiographic proposals submitted to the search. Of the 60 patients, 39 were female and 21 male, mean age 64 years (ranging from 50 to 84 years. Of the 60 knees studied, 37 corresponded to the right side and 23 on the left side. Statistical analysis was performed by Kappa statistics, which evaluates the interobserver agreement for qualitative data. RESULTS: According to the scale of Ahlbäck, there was a significant agreement (p < 0.0001 intra-observer in the classification of knee osteoarthritis among the five evaluators. There was a significant agreement (p < 0.0001 with inter-observer referring physician in the incidence of AP monopodal and AP bipedal for the four raters. CONCLUSION: The study found no difference between the incidence in the AP monopodal versus AP bipedal in osteoarthritis of the knee.

AIRE variations in Addison's disease and autoimmune polyendocrine syndromes (APS): partial gene deletions contribute to APS I.

Science.gov (United States)

Bøe Wolff, A S; Oftedal, B; Johansson, S; Bruland, O; Løvås, K; Meager, A; Pedersen, C; Husebye, E S; Knappskog, P M

2008-03-01

Autoimmune Addison's disease (AAD) is often associated with other components in autoimmune polyendocrine syndromes (APS). Whereas APS I is caused by mutations in the AIRE gene, the susceptibility genes for AAD and APS II are unclear. In the present study, we investigated whether polymorphisms or copy number variations in the AIRE gene were associated with AAD and APS II. First, nine SNPs in the AIRE gene were analyzed in 311 patients with AAD and APS II and 521 healthy controls, identifying no associated risk. Second, in a subgroup of 25 of these patients, AIRE sequencing revealed three novel polymorphisms. Finally, the AIRE copy number was determined by duplex quantitative PCR in 14 patients with APS I, 161 patients with AAD and APS II and in 39 healthy subjects. In two Scandinavian APS I patients previously reported to be homozygous for common AIRE mutations, we identified large deletions of the AIRE gene covering at least exon 2 to exon 8. We conclude that polymorphisms in the AIRE gene are not associated with AAD and APS II. We further suggest that DNA analysis of the parents of patients found to be homozygous for mutations in AIRE, always should be performed.

Autoantibody profiling in APS.

Science.gov (United States)

Roggenbuck, D; Somma, V; Schierack, P; Borghi, M O; Meroni, P L

2014-10-01

The international consensus for the classification of antiphospholipid syndrome (APS) requires clinical and laboratory criteria to be considered at an equal level for diagnosing APS. Thus, detection of antiphospholipid antibodies (aPL) being a hallmark of APS has been the object of intensive investigation over the past 40 years. However, appropriate detection of aPL still remains a laboratory challenge due to their heterogeneity comprising autoantibodies reactive to different phospholipid-binding plasma proteins, such as beta-2 glycoprotein I (β2GPI) and prothrombin. The relevance of aPL interacting with phospholipids other than cardiolipin (CL, diphosphatidylglycerol), such as phosphatidylserine (PS), remains elusive with regard to the diagnosis of APS. Recently, the concept of aPL profiling has been introduced to assess the risk of thrombotic complications in patients with APS. New assay techniques, apart from enzyme-linked immunosorbent assays (ELISAs) recommended by the international consensus for the classification of APS, have been proposed for multiplexing of aPL testing. Line immunoassays (LIAs) employing a novel hydrophobic solid phase for the simultaneous detection of different aPL seem to be an intriguing alternative. We evaluated a novel multiplex LIA employing a hydrophobic membrane coated with different phospholipid (PL)-binding proteins or PLs. The performance characteristics of this new multiplexing assay technique demonstrated its usefulness for aPL profiling. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Physico-chemical profiles of the wobble ↔ Watson-Crick G*·2AP(w) ↔ G·2AP(WC) and A·2AP(w) ↔ A*·2AP(WC) tautomerisations: a QM/QTAIM comprehensive survey.

Science.gov (United States)

Brovarets', Ol'ha O; Voiteshenko, Ivan S; Hovorun, Dmytro M

2017-12-20

This study is intended to clarify in detail the tautomeric transformations of the wobble (w) G*·2AP(w) and A·2AP(w) nucleobase mispairs involving 2-aminopurine (2AP) into the Watson-Crick (WC) G·2AP(WC) and A*·2AP(WC) base mispairs (asterisks denote mutagenic tautomers of the DNA bases), respectively, by quantum-mechanical methods and Bader's Quantum Theory of Atoms in Molecules. Our previously reported methodology has been used, which allows the evolution of the physico-chemical parameters to be tracked along the entire internal reaction coordinate (IRC), not exclusively in the stationary states of these reactions. These biologically important G*·2AP(w) ↔ G·2AP(WC) and A·2AP(w) ↔ A*·2AP(WC) w ↔ WC tautomerisations, which are involved in mutagenic tautomerically-conformational pathways, determine the origin of the transitions and transversions induced by 2AP. In addition, it is established that they proceed through planar, highly stable, zwitterionic transition states and they exhibit similar physico-chemical profiles and stages of sequential intrapair proton transfer, followed by spatial rearrangement of the nucleobases relative to each other within the base pairs. These w ↔ WC tautomerisations occur non-dissociatively and are accompanied by a significant alteration in geometry (from wobble to Watson-Crick and vice versa) and redistribution of the specific intermolecular interactions, which can be divided into 10 patterns including AHB H-bonds and loosened A-H-B covalent bridges along the IRC of tautomerisation. Based on the redistribution of the geometrical and electron-topological parameters of the intrapair hydrogen bonds, exactly 9 key points have been allocated to characterize the evolution of these reactions.

Tank characterization report for double-shell tank 241-AP-105

International Nuclear Information System (INIS)

DeLorenzo, D.S.; Simpson, B.C.

1994-01-01

Double-Shell Tank 241-AP-105 is a radioactive waste tank most recently sampled in March of 1993. Sampling and characterization of the waste in Tank 241-AP-105 contributes toward the fulfillment of Milestone M-44-05 of the Hanford Federal Facility Agreement and Consent Order (Ecology, EPA, and DOE, 1993). Characterization is also needed tot evaluate the waste's fitness for safe processing through an evaporator as part of an overall waste volume reduction program. Tank 241-AP-105, located in the 200 East Area AP Tank Farm, was constructed and went into service in 1986 as a dilute waste receiver tank; Tank 241AP-1 05 was considered as a candidate tank for the Grout Treatment Facility. With the cancellation of the Grout Program, the final disposal of the waste in will be as high- and low-level glass fractions. The tank has an operational capacity of 1,140,000 gallons, and currently contains 821,000 gallons of double-shell slurry feed. The waste is heterogeneous, although distinct layers do not exist. Waste has been removed periodically for processing and concentration through the 242-A Evaporator. The tank is not classified as a Watch List tank and is considered to be sound. There are no Unreviewed Safety Questions associated with Tank 241-AP-105 at this time. The waste in Tank 241-AP-105 exists as an aqueous solution of metallic salts and radionuclides, with limited amounts of organic complexants. The most prevalent soluble analytes include aluminum, potassium, sodium, hydroxide, carbonate, nitrate, and nitrite. The calculated pH is greater than the Resource Conservation and Recovery Act established limit of 12.5 for corrosivity. In addition, cadmium, chromium, and lead concentrations were found at levels greater than their regulatory thresholds. The major radionuclide constituent is 137 Cs, while the few organic complexants present include glycolate and oxalate. Approximately 60% of the waste by weight is water

The thermoluminscent dosimetry service of the radiation protection bureau

International Nuclear Information System (INIS)

1978-12-01

Thermoluminescent materials have been used in radiation dosimetry for many years, but their application to nationwide personnel dosimetry has been scarce. An undertaking of this nature requires that methods be established for identification of dosimeters and for fast interpretation and communication of dose to the users across the country. It is also necessary that records of cumulative dose of individual radiation workers be continuously updated, and such records be maintained for a prolonged period. To do this many problems pertinent to associated equpment, vis. the computer, TL reader, their interfacing, and to the operational procedures of the service had to be resolved. Since April 1977, the Radiation Protection Bureau has been providing a Thermoluminescent Dosimetry Service to Canadian radiation workers. This document describes the RPB dosimeter, its characteristics, various aspects of the service, objectives of the service, and how the objective goals of the service are achieved. (auth)

Hanford Radiological Protection Support Services Annual Report for 2000

Energy Technology Data Exchange (ETDEWEB)

Lynch, Timothy P.; Bihl, Donald E.; Johnson, Michelle L.; Maclellan, Jay A.; Piper, Roman K.

2001-05-07

During calendar year 2000, the Pacific Northwest National Laboratory performed its customary radiological protection support services in support of the U.S. Department of Energy Richland Operations Office and the Hanford contractors. These services included: 1) external dosimetry, 2) internal dosimetry, 3) in vivo monitoring, 4) radiological records, 5) instrument calibration and evaluation, and 6) calibration of radiation sources traceable to the National Institute of Standards and Technology. Each program summary describes the routine operations, program changes and improvements, program assessments, supporting technical studies, and professional activities.

Metallized solid rocket propellants based on AN/AP and PSAN/AP for access to space

Science.gov (United States)

Levi, S.; Signoriello, D.; Gabardi, A.; Molinari, M.; Galfetti, L.; Deluca, L. T.; Cianfanelli, S.; Klyakin, G. F.

2009-09-01

Solid rocket propellants based on dual mixes of inorganic crystalline oxidizers (ammonium nitrate (AN) and ammonium perchlorate (AP)) with binder and a mixture of micrometric-nanometric aluminum were investigated. Ammonium nitrate is a low-cost oxidizer, producing environment friendly combustion products but with lower specific impulse compared to AP. The better performance obtained with AP and the low quantity of toxic emissions obtained by using AN have suggested an interesting compromise based on a dual mixture of the two oxidizers. To improve the thermal response of raw AN, different types of phase stabilized AN (PSAN) and AN/AP co-crystals were investigated.

78 FR 5122 - NASA Security and Protective Services Enforcement

Science.gov (United States)

2013-01-24

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 14 CFR Parts 1203a, 1203b, and 1204 [Docket No NASA-2012-0007] RIN 2700-AD89 NASA Security and Protective Services Enforcement AGENCY: National Aeronautics... nonsubstantive changes to NASA regulations to clarify the procedures for establishing controlled/ secure areas...

Requirements of radiation protection and safety for nuclear medicine services

International Nuclear Information System (INIS)

1989-01-01

The requirements of radiation protection and safety for nuclear medicine services are established. The norms is applied to activities related to the radiopharmaceuticals for therapeutics and 'in vivo' diagnostics purposes. (M.C.K.) [pt

Obstetrical APS: is there a place for hydroxychloroquine to improve the pregnancy outcome?

Science.gov (United States)

Mekinian, Arsene; Costedoat-Chalumeau, Nathalie; Masseau, Agathe; Tincani, Angela; De Caroli, Sara; Alijotas-Reig, Jaume; Ruffatti, Amelia; Ambrozic, Ales; Botta, Angela; Le Guern, Véronique; Fritsch-Stork, Ruth; Nicaise-Roland, Pascale; Carbonne, Bruno; Carbillon, Lionel; Fain, Olivier

2015-01-01

The use of the conventional APS treatment (the combination of low-dose aspirin and LMWH) dramatically improved the obstetrical prognosis in primary obstetrical APS (OAPS). The persistence of adverse pregnancy outcome raises the need to find other drugs to improve obstetrical outcome. Hydroxychloroquine is widely used in patients with various autoimmune diseases, particularly SLE. Antimalarials have many anti-inflammatory, anti-aggregant and immune-regulatory properties: they inhibit phospholipase activity, stabilize lysosomal membranes, block the production of several pro-inflammatory cytokines and, in addition, impair complement-dependent antigen-antibody reactions. There is ample evidence of protective effects of hydroxychloroquine in OAPS similar to the situation in SLE arising from in vitro studies of pathophysiological working mechanism of hydroxychloroquine. However, the clinical data on the use of hydroxychloroquine in primary APS are lacking and prospective studies are necessary. Copyright © 2014 Elsevier B.V. All rights reserved.

AP1000. The PWR revisited

International Nuclear Information System (INIS)

Gaio, P.

2006-01-01

The distinguishing features of Westinghouse's AP1000 advanced passive pressurized water reactor are highlighted. In particular, the AP1000's passive safety features are described as well as their implications for simplifying the design, construction, and operation of this design compared to currently operating plants, and significantly increasing safety margins over current plants as well. The AP1000 design specifically incorporates the knowledge acquired from the substantial accumulation of power reactor operating experience and benefits from the application of the Probabilistic Risk Assessment in the design process itself. The AP1000 design has been certified by the US Nuclear Regulatory Commission under its new rules for licensing new nuclear plants, 10 CFR Part 52, and is the subject of six combined Construction and Operating License applications now being developed. Currently the AP1000 design is being assessed against the EUR Rev C requirements for new nuclear power plants in Europe. (author)

AP statistics crash course

CERN Document Server

D'Alessio, Michael

2012-01-01

AP Statistics Crash Course - Gets You a Higher Advanced Placement Score in Less Time Crash Course is perfect for the time-crunched student, the last-minute studier, or anyone who wants a refresher on the subject. AP Statistics Crash Course gives you: Targeted, Focused Review - Study Only What You Need to Know Crash Course is based on an in-depth analysis of the AP Statistics course description outline and actual Advanced Placement test questions. It covers only the information tested on the exam, so you can make the most of your valuable study time. Our easy-to-read format covers: exploring da

The role of consumer protection in ensuring quality in the hotel services market

Directory of Open Access Journals (Sweden)

Neacșu Andreea Nicoleta

2018-01-01

Full Text Available In Romania, tourism is an attractive sector with high potential, but unfortunately not exploited enough, so it is not yet a source of attraction for investors and foreign tourists. Most tourists are not satisfied with the quality of the hotel services in Romania and complain about it. The existence of adequate legislation on the protection of the consumer of tourist services could lead to the provision of quality services on this market and to a higher degree of tourists’ satisfaction.In the first part, this paper presents the public organizations dealing with the protection of the consumer on the hotel services market in Romania. The second part of the paper analyzes the quality of hotel services in Romania from the tourists’ point of view. In this respect, the author made a quantitative marketing research. The results featured the opinions and attitudes of tourists regarding the quality of hotel services in Romania.

A novel homozygous AP4B1 mutation in two brothers with AP-4 deficiency syndrome and ocular anomalies.

Science.gov (United States)

Accogli, Andrea; Hamdan, Fadi F; Poulin, Chantal; Nassif, Christina; Rouleau, Guy A; Michaud, Jacques L; Srour, Myriam

2018-04-01

Adaptor protein complex-4 (AP-4) is a heterotetrameric protein complex which plays a key role in vesicle trafficking in neurons. Mutations in genes affecting different subunits of AP-4, including AP4B1, AP4E1, AP4S1, and AP4M1, have been recently associated with an autosomal recessive phenotype, consisting of spastic tetraplegia, and intellectual disability (ID). The overlapping clinical picture among individuals carrying mutations in any of these genes has prompted the terms "AP-4 deficiency syndrome" for this clinically recognizable phenotype. Using whole-exome sequencing, we identified a novel homozygous mutation (c.991C>T, p.Q331*, NM_006594.4) in AP4B1 in two siblings from a consanguineous Pakistani couple, who presented with severe ID, progressive spastic tetraplegia, epilepsy, and microcephaly. Sanger sequencing confirmed the mutation was homozygous in the siblings and heterozygous in the parents. Similar to previously reported individuals with AP4B1 mutations, brain MRI revealed ventriculomegaly and white matter loss. Interestingly, in addition to the typical facial gestalt reported in other AP-4 deficiency cases, the older brother presented with congenital left Horner syndrome, bilateral optic nerve atrophy and cataract, which have not been previously reported in this condition. In summary, we report a novel AP4B1 homozygous mutation in two siblings and review the phenotype of AP-4 deficiency, speculating on a possible role of AP-4 complex in eye development. © 2018 Wiley Periodicals, Inc.

Automated Procurement System (APS): Project management plan (DS-03), version 1.2

Science.gov (United States)

Murphy, Diane R.

1994-01-01

The National Aeronautics and Space Administration (NASA) Marshall Space Flight Center (MSFC) is implementing an Automated Procurement System (APS) to streamline its business activities that are used to procure goods and services. This Project Management Plan (PMP) is the governing document throughout the implementation process and is identified as the APS Project Management Plan (DS-03). At this point in time, the project plan includes the schedules and tasks necessary to proceed through implementation. Since the basis of APS is an existing COTS system, the implementation process is revised from the standard SDLC. The purpose of the PMP is to provide the framework for the implementation process. It discusses the roles and responsibilities of the NASA project staff, the functions to be performed by the APS Development Contractor (PAI), and the support required of the NASA computer support contractor (CSC). To be successful, these three organizations must work together as a team, working towards the goals established in this Project Plan. The Project Plan includes a description of the proposed system, describes the work to be done, establishes a schedule of deliverables, and discusses the major standards and procedures to be followed.

Project W-211, initial tank retrieval systems, description of operations for 241-AP-102 and 241-AP-104

Energy Technology Data Exchange (ETDEWEB)

RIECK, C.A.

1999-02-25

The primary purpose of the Initial Tank Retrieval Systems (ITRS) is to provide systems for retrieval of radioactive wastes stored in underground double-shell tanks (DSTS) for transfer to alternate storage, evaporation, pretreatment or treatment, while concurrently reducing risks associated with safety watch list and other DSTs. This Description of Operations (DOO) defines the control philosophy for the waste retrieval system for tanks 241-AP-102 (AP-102) and 241-AP-104 (AP-104). This DOO will provide a basis for the detailed design of the Retrieval Control System (RCS) for AP-102 and AP-104 and establishes test criteria for the RCS. The test criteria will be used during qualification testing and acceptance testing to verify operability.

Project W-211, initial tank retrieval systems, description of operations for 241-AP-102 and 241-AP-104

International Nuclear Information System (INIS)

RIECK, C.A.

1999-01-01

The primary purpose of the Initial Tank Retrieval Systems (ITRS) is to provide systems for retrieval of radioactive wastes stored in underground double-shell tanks (DSTS) for transfer to alternate storage, evaporation, pretreatment or treatment, while concurrently reducing risks associated with safety watch list and other DSTs. This Description of Operations (DOO) defines the control philosophy for the waste retrieval system for tanks 241-AP-102 (AP-102) and 241-AP-104 (AP-104). This DOO will provide a basis for the detailed design of the Retrieval Control System (RCS) for AP-102 and AP-104 and establishes test criteria for the RCS. The test criteria will be used during qualification testing and acceptance testing to verify operability

Hanford radiological protection support services annual report for 1987

International Nuclear Information System (INIS)

Lyon, M.; Fix, J.J.; Kenoyer, J.L.; Leonowich, J.A.; Palmer, H.E.; Sula, M.J.

1988-08-01

This report documents the performance of certain radiological protection sitewide services during calendar year (CY) 1987 by Pacific Northwest Laboratory in support of the US Department of Energy-Richland Operations Office (DOE-RL) and contractor activities on the Hanford Site. The routine program for each service is discussed along with any significant program changes and tasks, investigations, and studies performed in support of each program. Other related activities such as publications, presentations, and memberships on standards or industry committees are also discussed. The programs covered provide services in the areas of: external dosimetry, internal dosimetry, in vivo measurements, instrument calibration and evaluation, calibration of radiation sources traceable to the National Bureau of Standards, and radiological records. 21 refs., 10 figs., 12 tabs

Greenhouse evaluation of Bacillus subtilis AP-01 and Trichoderma harzianum AP-001 in controlling tobacco diseases.

Science.gov (United States)

Maketon, Monchan; Apisitsantikul, Jirasak; Siriraweekul, Chatchai

2008-04-01

Two biological control agents, Bacillus subtilis AP-01 (Larminar(™)) and Trichoderma harzianum AP-001 (Trisan(™)) alone or/in combination were investigated in controlling three tobacco diseases, including bacterial wilt (Ralstonia solanacearum), damping-off (Pythium aphanidermatum), and frogeye leaf spot (Cercospora nicotiana). Tests were performed in greenhouse by soil sterilization prior to inoculation of the pathogens. Bacterial-wilt and damping off pathogens were drenched first and followed with the biological control agents and for comparison purposes, two chemical fungicides. But for frogeye leaf spot, which is an airborne fungus, a spraying procedure for every treatment including a chemical fungicide was applied instead of drenching. Results showed that neither B. subtilis AP-01 nor T harzianum AP-001 alone could control the bacterial wilt, but when combined, their controlling capabilities were as effective as a chemical treatment. These results were also similar for damping-off disease when used in combination. In addition, the combined B. subtilis AP-01 and T. harzianum AP-001 resulted in a good frogeye leaf spot control, which was not significantly different from the chemical treatment.

Ecosystem services in European protected areas: Ambiguity in the views of scientists and managers?

Directory of Open Access Journals (Sweden)

Christiaan Hummel

Full Text Available Protected Areas are a key component of nature conservation. They can play an important role in counterbalancing the impacts of ecosystem degradation. For an optimal protection of a Protected Area it is essential to account for the variables underlying the major Ecosystem Services an area delivers, and the threats upon them. Here we show that the perception of these important variables differs markedly between scientists and managers of Protected Areas in mountains and transitional waters. Scientists emphasise variables of abiotic and biotic nature, whereas managers highlight socio-economic, cultural and anthropogenic variables. This indicates fundamental differences in perception. To be able to better protect an area it would be advisable to bring the perception of scientists and managers closer together. Intensified and harmonised communication across disciplinary and professional boundaries will be needed to implement and improve Ecosystem Service oriented management strategies in current and future Protected Areas.

Ecosystem services in European protected areas: Ambiguity in the views of scientists and managers?

Science.gov (United States)

Provenzale, Antonello; van der Meer, Jaap; Wijnhoven, Sander; Nolte, Arno; Poursanidis, Dimitris; Janss, Guyonne; Jurek, Matthias; Andresen, Magnus; Poulin, Brigitte; Kobler, Johannes; Beierkuhnlein, Carl; Honrado, João; Razinkovas, Arturas; Stritih, Ana; Bargmann, Tessa; Ziemba, Alex; Bonet-García, Francisco; Adamescu, Mihai Cristian; Janssen, Gerard; Hummel, Herman

2017-01-01

Protected Areas are a key component of nature conservation. They can play an important role in counterbalancing the impacts of ecosystem degradation. For an optimal protection of a Protected Area it is essential to account for the variables underlying the major Ecosystem Services an area delivers, and the threats upon them. Here we show that the perception of these important variables differs markedly between scientists and managers of Protected Areas in mountains and transitional waters. Scientists emphasise variables of abiotic and biotic nature, whereas managers highlight socio-economic, cultural and anthropogenic variables. This indicates fundamental differences in perception. To be able to better protect an area it would be advisable to bring the perception of scientists and managers closer together. Intensified and harmonised communication across disciplinary and professional boundaries will be needed to implement and improve Ecosystem Service oriented management strategies in current and future Protected Areas. PMID:29140983

Ecosystem services in European protected areas: Ambiguity in the views of scientists and managers?

Science.gov (United States)

Hummel, Christiaan; Provenzale, Antonello; van der Meer, Jaap; Wijnhoven, Sander; Nolte, Arno; Poursanidis, Dimitris; Janss, Guyonne; Jurek, Matthias; Andresen, Magnus; Poulin, Brigitte; Kobler, Johannes; Beierkuhnlein, Carl; Honrado, João; Razinkovas, Arturas; Stritih, Ana; Bargmann, Tessa; Ziemba, Alex; Bonet-García, Francisco; Adamescu, Mihai Cristian; Janssen, Gerard; Hummel, Herman

2017-01-01

Protected Areas are a key component of nature conservation. They can play an important role in counterbalancing the impacts of ecosystem degradation. For an optimal protection of a Protected Area it is essential to account for the variables underlying the major Ecosystem Services an area delivers, and the threats upon them. Here we show that the perception of these important variables differs markedly between scientists and managers of Protected Areas in mountains and transitional waters. Scientists emphasise variables of abiotic and biotic nature, whereas managers highlight socio-economic, cultural and anthropogenic variables. This indicates fundamental differences in perception. To be able to better protect an area it would be advisable to bring the perception of scientists and managers closer together. Intensified and harmonised communication across disciplinary and professional boundaries will be needed to implement and improve Ecosystem Service oriented management strategies in current and future Protected Areas.

ApS de Mediación Artística: Mujer y violencia de género

OpenAIRE

GUILLEM CASAÑ, LIVIA

2018-01-01

Proyecto basado en ApS a través de la programación de acción de Mediación Artística dirigida a un colectivo con necesidades especiales, en este caso, mujeres que han sufrido maltrato. Proponiendo realizar una serie de prácticas artísticas que tienen como objetivos ayudar a potenciar la confianza, el desarrollo integral, la autonomía, la cooperación y la superación de conflictos. Todo ello coordinado junto con las terapeutas de la Asociación ALANNA y LILITH. Project based on ApS through the...

Assessing Protective Factors for Violence Risk in U.K. General Mental Health Services Using the Structured Assessment of Protective Factors.

Science.gov (United States)

Haines, Alina; Brown, Andrew; Javaid, Syed Fahad; Khan, Fayyaz; Noblett, Steve; Omodunbi, Oladipupo; Sadiq, Khurram; Zaman, Wahid; Whittington, Richard

2017-12-01

Violence risk assessment and management are key tasks in mental health services and should be guided by validated instruments covering both risk and protective factors. This article is part of an international effort to validate the Structured Assessment of Protective Factors (SAPROF) for violence. The SAPROF, Historical, Clinical, Risk Management-20 (HCR-20) and the Psychopathy Checklist-Screening Version (PCL-SV) were administered in a sample of 261 patients in U.K. forensic, general inpatient, and community mental health settings. There was significant variation between these groups on SAPROF scores with fewer protective factors in the forensic group. The prospective validity of the SAPROF for nonviolence in the general inpatient and community samples was moderate (area under the curve [AUC] = .60). Adoption of the SAPROF or similar instruments as a supplement to risk-focused assessments has the potential to improve awareness of protective factors and enhance therapeutic engagement in a range of mental health services.

Ecosystem services in European protected areas: Ambiguity in the views of scientists and managers?

NARCIS (Netherlands)

Hummel, C.; Provenzale, A.; Van der Meer, J.; Wijnhoven, S.; Nolte, A.; Poursanidis, D.; Janss, G.; Jurek, M.; Andresen, M.; Poulin, B.; Kobler, J.; Beierkuhnlein, C.; Honrado, J.; Razinkovas, A.; Stritih, A.; Bargmann, T.; Ziemba, A.; Bonet-García, F.; Adamescu, M.C.; Janssen, G.; Hummel, H.

2017-01-01

Protected Areas are a key component of nature conservation. They can play an important role in counterbalancing the impacts of ecosystem degradation. For an optimal protection of a Protected Area it is essential to account for the variables underlying the major Ecosystem Services an area delivers,

An AP Calculus Classroom Amusement Park

Science.gov (United States)

Ferguson, Sarah

2016-01-01

Throughout the school year, AP Calculus teachers strive to teach course content comprehensively and swiftly in an effort to finish all required material before the AP Calculus exam. As early May approaches and the AP Calculus test looms, students and teachers nervously complete lessons, assignments, and assessments to ensure student preparation.…

Assessment of the Ecosystem Services Capacity in Natural Protected Areas for Biodiversity Conservation

Science.gov (United States)

Ronchi, Silvia; Salata, Stefano

2017-10-01

Recently, in Italy, a legislative proposal has been set to reform the role and the functions of natural protected areas promoting their aggregation (or the abolition) pursuing a better efficiency for their administration and economic saving. The system of natural protected areas is composed of different conservation levels: there are the Natural parks, established in the ‘80 by national or regional institution for the safeguard of natural elements, the Natura 2000 -Habitat 92/43/CEE promoted by European Union, with conservation measures for maintaining or restoring habitats and species of Communitarian interest, and the local parks of supra-municipal interest (namely PLIS) created by single municipalities or their aggregation aimed at limiting the soil sealing process. The hierarchical level of protection has determined differences in the management of the areas which leads to various approaches and strategies for biodiversity conservation and integrity. In order to assess strengths and weaknesses of the legislative initiative, the new management framework should be designed, considering the ecosystem characteristics of each natural protected area to define the future opportunities and critics, rather than, in the extreme case, remove the level of protection due to the absence of valuable ecosystem conditions. The paper provides an operative support to better apply the legislative proposal investigating the dynamics that affect all protected areas using the land take process as a major threat to biodiversity conservation in natural zones. The land take process is explored using the Land Use Change analysis (LUCa) as a possible way to determine the impact and the environmental effects of land transitions. LUCa is also useful to determine the loss of protected zones capacity to support Ecosystem Services. Finally, the assessment of the Ecosystem Services Capacity (ESC) index expresses the ability of each LULC to provide ES and, in particular, the Ecological

AP1000, a nuclear central of advanced design; AP1000, una central nuclear de diseno avanzado

Energy Technology Data Exchange (ETDEWEB)

Hernandez M, N.; Viais J, J. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: nhm@nuclear.inin.mx

2005-07-01

The AP1000 is a design of a nuclear reactor of pressurized water (PWR) of 1000 M We with characteristic of safety in a passive way; besides presenting simplifications in the systems of the plant, the construction, the maintenance and the safety, the AP1000 is a design that uses technology endorsed by those but of 30 years of operational experience of the PWR reactors. The program AP1000 of Westinghouse is focused to the implementation of the plant to provide improvements in the economy of the same one and it is a design that is derived directly of the AP600 designs. On September 13, 2004 the US-NRC (for their initials in United States- Nuclear Regulatory Commission) approved the final design of the AP1000, now Westinghouse and the US-NRC are working on the whole in a complete program for the certification. (Author)

A Genetic Algorithms-based Approach for Optimized Self-protection in a Pervasive Service Middleware

DEFF Research Database (Denmark)

Zhang, Weishan; Ingstrup, Mads; Hansen, Klaus Marius

2009-01-01

With increasingly complex and heterogeneous systems in pervasive service computing, it becomes more and more important to provide self-protected services to end users. In order to achieve self-protection, the corresponding security should be provided in an optimized manner considering...... the constraints of heterogeneous devices and networks. In this paper, we present a Genetic Algorithms-based approach for obtaining optimized security configurations at run time, supported by a set of security OWL ontologies and an event-driven framework. This approach has been realized as a prototype for self-protection...... in the Hydra middleware, and is integrated with a framework for enforcing the computed solution at run time using security obligations. The experiments with the prototype on configuring security strategies for a pervasive service middleware show that this approach has acceptable performance, and could be used...

AP1000 - update on projects in US and China

Energy Technology Data Exchange (ETDEWEB)

Godfrey, M. [Westinghouse Electric Company, Cranberry Township, Pennsy lvania (United States)

2012-07-01

Westinghouse is the only company solely focused on commercial nuclear technology. Westinghouse business is based on four product lines regionally divided: nuclear power plants, nuclear fuel, nuclear services and nuclear automation. The AP1000 is the technology of choice for more than half of the new plants identified in the US. Westinghouse has the only certified Generation III+ technology by the US Nuclear Regulatory Commission (NRC). The first Generation III+ plants are under construction in China and the US.

AP1000 - update on projects in US and China

International Nuclear Information System (INIS)

Godfrey, M.

2012-01-01

Westinghouse is the only company solely focused on commercial nuclear technology. Westinghouse business is based on four product lines regionally divided: nuclear power plants, nuclear fuel, nuclear services and nuclear automation. The AP1000 is the technology of choice for more than half of the new plants identified in the US. Westinghouse has the only certified Generation III+ technology by the US Nuclear Regulatory Commission (NRC). The first Generation III+ plants are under construction in China and the US.

Low-canopy seagrass beds still provide important coastal protection services

NARCIS (Netherlands)

Christianen, M.J.A.; van Belzen, J.; Herman, P.M.J.; van Katwijk, M.M.; Lamers, L.P.M.; Bouma, T.J.

2013-01-01

One of the most frequently quoted ecosystem services of seagrass meadows is their value for coastal protection. Many studies emphasize the role of above-ground shoots in attenuating waves, enhancing sedimentation and preventing erosion. This raises the question if short-leaved, low density (grazed)

Advanced APS Impacts on Vehicle Payloads

Science.gov (United States)

Schneider, Steven J.; Reed, Brian D.

1989-01-01

Advanced auxiliary propulsion system (APS) technology has the potential to both, increase the payload capability of earth-to-orbit (ETO) vehicles by reducing APS propellant mass, and simplify ground operations and logistics by reducing the number of fluids on the vehicle and eliminating toxic, corrosive propellants. The impact of integrated cryogenic APS on vehicle payloads is addressed. In this system, launch propulsion system residuals are scavenged from integral launch propulsion tanks for use in the APS. Sufficient propellant is preloaded into the APS to return to earth with margin and noncomplete scavenging assumed. No propellant conditioning is required by the APS, but ambient heat soak is accommodated. High temperature rocket materials enable the use of the unconditioned hydrogen/oxygen in the APS and are estimated to give APS rockets specific impulse of up to about 444 sec. The payload benefits are quantified and compared with an uprated monomethyl hydrazine/nitrogen tetroxide system in a conservative fashion, by assuming a 25.5 percent weight growth for the hydrogen/oxygen system and a 0 percent weight growth for the uprated system. The combination and scavenging and high performance gives payload impacts which are highly mission specific. A payload benefit of 861 kg (1898 lbm) was estimated for a Space Station Freedom rendezvous mission and 2099 kg (4626 lbm) for a sortie mission, with payload impacts varying with the amount of launch propulsion residual propellants. Missions without liquid propellant scavenging were estimated to have payload penalties, however, operational benefits were still possible.

Resolution no. 19/2012 Guide for the recognition of the competence of services courses in radiation protection

International Nuclear Information System (INIS)

2013-01-01

The Guide aims to: establish requirements for Services courses on Radiological Protection, for the purpose of recognizing the jurisdiction; and establish the documentation to be submitted to the application of Recognition Competition Services courses in radiation protection.

AP1000 design and construction integration

International Nuclear Information System (INIS)

Winters, James W.; Clelland, Jill A.

2004-01-01

Construction costs of commercial nuclear generating plants must be reduced in order to expand the future use of nuclear energy. Two of the drivers of plant construction costs are the cost of financing during the construction duration and the substantial amount of skilled craft labor hours needed on site during construction. The application of information technology (IT) has been used to understand and reduce both of these drivers by establishing parallel construction paths using modules and integrating construction sequence review into the design process. In a program sponsored by EPRI, Westinghouse has modeled the construction of AP1000 in '4D' to show its viability, to improve its logic, to improve the plant design for constructibility and overall to reduce time and risk in the construction schedule. The design of most of AP1000 was constrained to be a duplicate of AP600 except where components required expansion for the higher power level. As a result, the construction schedule for AP1000 is as mature and as robust as that for AP600. Two areas important to the construction of AP1000 did require some design work because they could not remain the same as AP1000. First, the turbine building had to be redesigned to accommodate the larger turbine and its support systems. Again, as much of the AP600 design and philosophy as possible was retained. The building required enlargement and the basemat, foundations, steel structure and structural modules required modification. As concrete, steel, and equipment were defined by the designers, they were matched to the original AP600 turbine building schedule. This forced designers to assemble files to be consistent with building assembly activities and to think about constructibility as they defined the final design. Second, the reinforcement structure within the concrete under and supporting the containment vessel required detail design. Westinghouse was fortunate to have the constructor Obayashi of Japan recommend a detailed

AP600 large-break loss-of-collant-accident developmental assessment plan for TRAC-PF1/MOD2

International Nuclear Information System (INIS)

Knight, T.D.

1996-07-01

The Westinghouse AP600 reactor is an advanced pressurized water reactor with passive safety systems to protect the plant against possible accidents and transients. The design has been submitted to the U.S. NRC for design certification. The NRC has selected the Transient Reactor Analysis Code (TRAC)-PF1/MOD2 for performing large break loss-of coolant-accident (LBLOCA) analysis to support the certification effort. This document defines the tests to be used in the current phase of developmental assessment related to AP600 LBLOCA

Predicting the decisions of hospital based child protection teams to report to child protective services, police and community welfare services.

Science.gov (United States)

Benbenishty, Rami; Jedwab, Merav; Chen, Wendy; Glasser, Saralee; Slutzky, Hanna; Siegal, Gil; Lavi-Sahar, Zohar; Lerner-Geva, Liat

2014-01-01

This study examines judgments made by hospital-based child protection teams (CPTs) when determining if there is reasonable suspicion that a child has been maltreated, and whether to report the case to a community welfare agency, to child protective services (CPS) and/or to the police. A prospective multi-center study of all 968 consecutive cases referred to CPTs during 2010-2011 in six medical centers in Israel. Centers were purposefully selected to represent the heterogeneity of medical centers in Israel in terms of size, geographical location and population characteristics. A structured questionnaire was designed to capture relevant information and judgments on each child referred to the team. Bivariate associations and multivariate multinomial logistic regressions were conducted to predict whether the decisions would be (a) to close the case, (b) to refer the case to community welfare services, or (c) to report it to CPS and/or the police. Bivariate and multivariate analyses identified a large number of case characteristics associated with higher probability of reporting to CPS/police or of referral to community welfare services. Case characteristics associated with the decisions include socio-demographic (e.g., ethnicity and financial status), parental functioning (e.g., mental health), previous contacts with authorities and hospital, current referral characteristics (e.g., parental referral vs. child referral), physical findings, and suspicious behaviors of child and parent. Most of the findings suggest that decisions of CPTs are based on indices that have strong support in the professional literature. Existing heterogeneity between cases, practitioners and medical centers had an impact on the overall predictability of the decision to report. Attending to collaboration between hospitals and community agencies is suggested to support learning and quality improvement. Copyright © 2013 Elsevier Ltd. All rights reserved.

AP1000{sup TM} plant modularization

Energy Technology Data Exchange (ETDEWEB)

Cantarero L, C.; Demetri, K. J. [Westinghouse Electric Co., 1000 Westinghouse Drive, Cranberry Township, PA 16066 (United States); Quintero C, F. P., E-mail: cantarc@westinghouse.com [Westinghouse Electric Spain, Padilla 17, 28006 Madrid (Spain)

2016-09-15

The AP1000{sup TM} plant is an 1100 M We pressurized water reactor (PWR) with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance and safety. Modules are used extensively in the design of the AP1000 plant nuclear island. The AP1000 plant uses modern, modular-construction techniques for plant construction. The design incorporates vendor-designed skids and equipment packages, as well as large, multi-ton structural modules and special equipment modules. Modularization allows traditionally sequential construction tasks to be completed simultaneously. Factory-built modules can be installed at the site in a planned construction schedule. The modularized AP1000 plant allows many more construction activities to proceed in parallel. This reduces plant construction calendar time, thus lowering the costs of plant financing. Furthermore, performing less work onsite significantly reduces the amount of skilled field-craft labor, which costs more than shop labor. In addition to labor cost savings, doing more welding and fabrication in a factory environment raises the quality of work, allowing more scheduling flexibility and reducing the amount of specialized tools required onsite. The site layout for the AP1000 plant has been established to support modular construction and efficient operations during construction. The plant layout is compact, using less space than previous conventional plant layouts. This paper provides and overview of the AP1000 plant modules with an emphasis on structural modules. Currently the Westinghouse AP1000 plant has four units under construction in China and four units under construction in the United States. All have shown successful fabrication and installation of various AP1000 plant modules. (Author)

AP1000"T"M plant modularization

International Nuclear Information System (INIS)

Cantarero L, C.; Demetri, K. J.; Quintero C, F. P.

2016-09-01

The AP1000"T"M plant is an 1100 M We pressurized water reactor (PWR) with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance and safety. Modules are used extensively in the design of the AP1000 plant nuclear island. The AP1000 plant uses modern, modular-construction techniques for plant construction. The design incorporates vendor-designed skids and equipment packages, as well as large, multi-ton structural modules and special equipment modules. Modularization allows traditionally sequential construction tasks to be completed simultaneously. Factory-built modules can be installed at the site in a planned construction schedule. The modularized AP1000 plant allows many more construction activities to proceed in parallel. This reduces plant construction calendar time, thus lowering the costs of plant financing. Furthermore, performing less work onsite significantly reduces the amount of skilled field-craft labor, which costs more than shop labor. In addition to labor cost savings, doing more welding and fabrication in a factory environment raises the quality of work, allowing more scheduling flexibility and reducing the amount of specialized tools required onsite. The site layout for the AP1000 plant has been established to support modular construction and efficient operations during construction. The plant layout is compact, using less space than previous conventional plant layouts. This paper provides and overview of the AP1000 plant modules with an emphasis on structural modules. Currently the Westinghouse AP1000 plant has four units under construction in China and four units under construction in the United States. All have shown successful fabrication and installation of various AP1000 plant modules. (Author)

Hanford radiological protection support services annual report for 1988

International Nuclear Information System (INIS)

Lyon, M.; Fix, J.J.; Kenoyer, J.L.; Leonowich, J.A.; Palmer, H.E.; Sula, M.J.

1989-06-01

The report documents the performance of certain radiological protection sitewide services during calendar year (CY) 1988 by Pacific Northwest Laboratory (PNL) in support of the US Department of Energy-Richland Operations Office (DOE-RL) and contractor activities on the Hanford Site. The routine program for each service is discussed along with any significant program changes and tasks, investigations, and studies performed in support of each program. Other related activities such as publications, presentations, and memberships on standard or industry committees are also listed. The programs covered provide services in the areas of (1) internal dosimetry, (2) in vivo measurements, (3) external dosimetry, (4) instrument calibration and evaluation, (5) calibration of radiation sources traceable to the National Institute of Standards and Technology (NIST) (formerly the National Bureau of Standards), and (6) radiological records. 23 refs., 15 figs., 15 tabs

Basic principles and guidelines governing services of the police for the protection of nuclear installations

International Nuclear Information System (INIS)

Schulte, R.; Kern, R.

1989-01-01

Services of the police can be ordered for physical protection of nuclear installations of any kind and of nuclear materials transports in cases where there is danger that those first responsible cannot cope with the situation. The contribution discusses physical protection measures as a licensing requirement, the duties of the police forces within the given scope, the measures that can and may be taken by the police, the establishment of special commissions, as well as the particular provisions for nuclear materials transports. The provisions governing police services for physical protection have led to an efficient and well furnished system in terms of organisation, personnel, and materials, which guarantees protection to a great extent. (orig./HSCH) [de

AP calculus AB & BC crash course

CERN Document Server

Rosebush, J

2012-01-01

AP Calculus AB & BC Crash Course - Gets You a Higher Advanced Placement Score in Less Time Crash Course is perfect for the time-crunched student, the last-minute studier, or anyone who wants a refresher on the subject. AP Calculus AB & BC Crash Course gives you: Targeted, Focused Review - Study Only What You Need to Know Crash Course is based on an in-depth analysis of the AP Calculus AB & BC course description outline and actual AP test questions. It covers only the information tested on the exams, so you can make the most of your valuable study time. Written by experienced math teachers, our

Westinghouse AP 1000 program status

International Nuclear Information System (INIS)

Doehnert, B.

2002-01-01

The project 1000 is presented and features are discussed in the paper. Design maturity is characterized by 1300 man-year / $400 million design and testing effort, more than 12 000 design documents completed; 3D computer model developed. It includes structures, equipment, small / large pipe, cable trays, ducts etc. Licensing Maturity is determined by a very thorough and complete NRC review of AP600; 110 man-year effort (NRC) over 6 years, $30 million; independent, confirmatory plant analysis; independent, confirmatory plant testing (ROSA, OSU); over 7400 questions answered, no open items; over 380 meeting with NRC, 43 meetings with ACRS. NRC Design Certification is issued in December 1999. Reasons for developing AP 1000 and design changes are presented. Economic analysis shows an expectation for payback within 20 years. AP1000 provides 75% power uprate for 15% increment in capital cost. AP1000 meets new plant economic targets in the near term

Evaluation of Legal Data Protection Requirements in Cloud Services in the Context of Contractual Relations with End-Users

Directory of Open Access Journals (Sweden)

Darius Štitilis

2014-03-01

Full Text Available Purpose – to analyse the compliance with basic principles of data protection in selected consumer oriented cloud services contracts, and also to highlight the adequate level of data protection in the mentioned contracts, evaluating existing data protection directive 95/46/EC, also proposed General data protection regulation.Design/methodology/approach – various survey methods have been used in the work integrated. Documental analysis method has been used in analysis of scientific literature, legal acts and other documents, where aspects of legal data protection requirements have been included. Legal documents analysis method together with logical-analytic method has been used in analysing Directive 95/46/EU, Proposal for a regulation of the European Parliament and of the Council and jurisprudence of the European Court of Human Rights. Comparative method has been applied for revealing difference between particular cloud services contracts and also comparing the compliance of cloud services contracts to requirements of basic European data protection principles, established in the international documents.Findings – from the brief analysis of selected consumer oriented cloud service providers, it may be implied that more or less all the legal principles, established in the legal acts, are reflected in the privacy policies and/or service agreements. However, it shall be noted that there is a big difference in wording of the analysed documents. Regarding other principles, all examined cloud service providers do not have indemnification provisions regarding unlawful use of personal data.Research limitations/implications – the concept of the contract was presented in a broad sense, including the privacy policies and/or terms and conditions of the service providers. In accordance with the content of the principles, the authors grouped data protection principles, applied in cloud services into fundamental and recommendatory.Practical implications

APS Education and Diversity Efforts

Science.gov (United States)

Prestridge, Katherine; Hodapp, Theodore

2015-11-01

American Physical Society (APS) has a wide range of education and diversity programs and activities, including programs that improve physics education, increase diversity, provide outreach to the public, and impact public policy. We present the latest programs spearheaded by the Committee on the Status of Women in Physics (CSWP), with highlights from other diversity and education efforts. The CSWP is working to increase the fraction of women in physics, understand and implement solutions for gender-specific issues, enhance professional development opportunities for women in physics, and remedy issues that impact gender inequality in physics. The Conferences for Undergraduate Women in Physics, Professional Skills Development Workshops, and our new Professional Skills program for students and postdocs are all working towards meeting these goals. The CSWP also has site visit and conversation visit programs, where department chairs request that the APS assess the climate for women in their departments or facilitate climate discussions. APS also has two significant programs to increase participation by underrepresented minorities (URM). The newest program, the APS National Mentoring Community, is working to provide mentoring to URM undergraduates, and the APS Bridge Program is an established effort that is dramatically increasing the number of URM PhDs in physics.

[Apheresis in antiphospholipid syndrome (APS)].

Science.gov (United States)

De Silvestro, Giustina; Tison, Tiziana; Marson, Piero

2012-01-01

Antiphospholipid syndrome (APS) is a rare clinical disorder characterized by thromboembolic manifestations and/or obstetric complications. Along with the clinical symptoms and signs, serum antiphospholipid antibodies have to be detected. APS can be primary, i.e., without any concomitant disorders, or secondary to other autoimmune diseases, particularly systemic lupus erythematosus. Criteria for the diagnosis of APS have been clearly established. Hyperacute APS (or catastrophic antiphospholipid syndrome), often with a poor prognosis, must meet four criteria: involvement of three or more organs, rapid evolution of clinical manifestations, microangiopathic occlusion of small blood vessels at biopsy, and presence of antiphospholipid antibodies. The rationale for apheresis treatment is the removal of pathogenetic antibodies involved in the development of tissue damage. Our experience includes 23 patients, in particular 15 women treated for 19 pregnancies. According to the National Guidelines Program, the effectiveness of apheresis in catastrophic syndrome has a level of evidence of V/VI, with a strength of recommendation A; in highrisk pregnancy it has a level of evidence of V with a strength of recommendation B. It will be necessary to better define the prognosis of various categories of pregnant patients with APS, as well as useful laboratory parameters to monitor its clinical course and anticipate any complications of pregnancy.

Validity of the Working Alliance Inventory within Child Protection Services

Science.gov (United States)

Killian, Michael; Forrester, Donald; Westlake, David; Antonopoulou, Paraskevi

2017-01-01

The Working Alliance Inventory remains a widely studied measure of quality of therapeutic relationships between the practitioner and client. No prior study has examined the psychometrics and validity of the Working Alliance Inventory-Short (WAI-S) in a sample of families, social workers, and trained observers within child protection services.…

76 FR 66940 - Privacy Act of 1974; Department of Homeland Security/United States Secret Service-004 Protection...

Science.gov (United States)

2011-10-28

... DEPARTMENT OF HOMELAND SECURITY Office of the Secretary [Docket No. DHS-2011-0083] Privacy Act of 1974; Department of Homeland Security/United States Secret Service--004 Protection Information System... Security (DHS)/United States Secret Service (USSS)-004 System name: DHS/USSS-004 Protection Information...

Update on the development of cotton gin PM10 emission factors for EPA's AP-42

Science.gov (United States)

A cotton ginning industry-supported project was initiated in 2008 to update the U.S. Environmental Protection Agency’s (EPA) Compilation of Air Pollution Emission Factors (AP-42) to include PM10 emission factors. This study develops emission factors from the PM10 emission factor data collected from ...

A Privacy-Protecting Authentication Scheme for Roaming Services with Smart Cards

Science.gov (United States)

Son, Kyungho; Han, Dong-Guk; Won, Dongho

In this work we propose a novel smart card based privacy-protecting authentication scheme for roaming services. Our proposal achieves so-called Class 2 privacy protection, i.e., no information identifying a roaming user and also linking the user's behaviors is not revealed in a visited network. It can be used to overcome the inherent structural flaws of smart card based anonymous authentication schemes issued recently. As shown in our analysis, our scheme is computationally efficient for a mobile user.

APS Science 2007.

Energy Technology Data Exchange (ETDEWEB)

2008-05-30

This report provides research highlights from the Advanced Photon Source (APS). Although these highlights represent less than 10% of the published work from the APS in 2007, they give a flavor of the diversity and impact of user research at the facility. In the strategic planning the aim is to foster the growth of existing user communities and foresee new areas of research. This coming year finds the APS engaged in putting together, along with the users, a blueprint for the next five years, and making the case for a set of prioritized investments in beamlines, the accelerator, and infrastructure, each of which will be transformational in terms of scientific impact. As this is written plans are being formulated for an important user workshop on October 20-21, 2008, to prioritize strategic plans. The fruit from past investments can be seen in this report. Examples include the creation of a dedicated beamline for x-ray photon correlation spectroscopy at Sector 8, the evolution of dedicated high-energy x-ray scattering beamlines at sectors 1 and 11, a dedicated imaging beamline at Sector 32, and new beamlines for inelastic scattering and powder diffraction. A single-pulse facility has been built in collaboration with Sector 14 (BioCARS) and Phil Anfinrud at the National Institutes of Health, which will offer exceptionally high flux for single-pulse diffraction. The nanoprobe at Sector 26, built and operated jointly by the Argonne Center for Nanoscale Materials and the X-ray Operations and Research (XOR) section of the APS X-ray Science Division, has come on line to define the state of the art in nanoscience.

APS Science 2007

International Nuclear Information System (INIS)

2008-01-01

This report provides research highlights from the Advanced Photon Source (APS). Although these highlights represent less than 10% of the published work from the APS in 2007, they give a flavor of the diversity and impact of user research at the facility. In the strategic planning the aim is to foster the growth of existing user communities and foresee new areas of research. This coming year finds the APS engaged in putting together, along with the users, a blueprint for the next five years, and making the case for a set of prioritized investments in beamlines, the accelerator, and infrastructure, each of which will be transformational in terms of scientific impact. As this is written plans are being formulated for an important user workshop on October 20-21, 2008, to prioritize strategic plans. The fruit from past investments can be seen in this report. Examples include the creation of a dedicated beamline for x-ray photon correlation spectroscopy at Sector 8, the evolution of dedicated high-energy x-ray scattering beamlines at sectors 1 and 11, a dedicated imaging beamline at Sector 32, and new beamlines for inelastic scattering and powder diffraction. A single-pulse facility has been built in collaboration with Sector 14 (BioCARS) and Phil Anfinrud at the National Institutes of Health, which will offer exceptionally high flux for single-pulse diffraction. The nanoprobe at Sector 26, built and operated jointly by the Argonne Center for Nanoscale Materials and the X-ray Operations and Research (XOR) section of the APS X-ray Science Division, has come on line to define the state of the art in nanoscience

[Traditional risk factors for cardiovascular disease in primary antiphospholipid syndrome (APS) when compared with secondary APS: a study with 96 patients].

Science.gov (United States)

Ribeiro, A R; Carvalho, J F

2010-01-01

To evaluate the prevalence of traditional risk factors in patients with primary antiphospholipid syndrome (APS) in comparison to those with systemic lupus erythematosus-secondary APS. Transversal study of 96 APS patients (Sapporo's criteria). Demographic and clinical data, cardiovascular risk factors and drug use were investigated. Thirty-nine Primary APS and 57 secondary APS were included. The groups did not differ regarding age (38.5 +/- 9.9 vs. 39.4 +/- 10.5 years, p=0.84) and female gender (84.6 vs. 96.5%, p=0.06), respectively. Arterial events were more observed in primary than secondary APS (59 vs. 36.8%, p=0.04) patients. No difference was seen concerning venous and obstetric events. In regard to traditional risk factors for cardiovascular disease, both groups were comparable related to current or previous smoking, sedentarism, family history for coronary disease, systemic hypertension, diabetes mellitus, overweight and obesity. The frequencies of altered lipid profiles were alike in the two groups, except for a higher prevalence of low HDL-c levels in primary APS group (84.6 vs. 45.5%, p=0.0001). Concerning drug use, no significant differences were observed related to chloroquine and statin use, however the secondary APS patients had a higher rate of prednisone use (10.2 vs. 57.9%, pAPS, except for a high frequency of low HDL-c in primary APS patients.

Compliance with technical standards for radiological protection at radiation therapy services in Sao Paulo State, Brazil

International Nuclear Information System (INIS)

Eduardo, Maria Bernadete de Paula; Novaes, Hillegonda Maria Dutilh

2004-01-01

Radiation therapy services provide essential therapeutic procedures for cancer, one of the main causes of population morbidity and mortality. Despite their importance in the health system and their potential risks due to the use of ionizing radiation, there are few studies on such services. We evaluated compliance with technical standards for radiological protection in radiation therapy services in Sao Paulo State, Brazil. Forty-nine services were studied in 2000 through interviews with technical staff. Typologies of performance profiles focusing on structure and process variables were constructed and services compared. Important differences were observed in the services' positions in the health care system, level of complexity, and geographic distribution, with better average performance in structural conditions but very inadequate performance in patient protection, indicating the need for more effective health surveillance. (author)

[Type 2 autoimmune polyendocrine syndromes (APS-2)].

Science.gov (United States)

Vialettes, Bernard; Dubois-Leonardon, Noémie

2013-01-01

Type 2 autoimmune polyendocrine syndromes (APS-2) are the most frequent disorders associating several organ-specific autoimmune diseases. Their high prevalence is due to the fact that the main manifestations of APS-2, such as thyroidal autoimmunity, type 1 diabetes, autoimmune gastric atrophy and vitiligo, are common diseases. APS-2 represents a clinical model that can serve to help unravel the mechanisms underlying autoimmunity. Diagnosis of APS-2 is a challenge for the clinician, especially in poorly symptomatic forms, and may require systematic screening based on measurement of autoantibodies and functional markers.

AP1000 Containment Design and Safety Assessment

International Nuclear Information System (INIS)

Wright, Richard F.; Ofstun, Richard P.; Bachere, Sebastien

2002-01-01

The AP1000 is an up-rated version of the AP600 passive plant design that recently received final design certification from the US NRC. Like AP600, the AP1000 is a two-loop, pressurized water reactor featuring passive core cooling and passive containment safety systems. One key safety feature of the AP1000 is the passive containment cooling system which maintains containment integrity in the event of a design basis accident. This system utilizes a high strength, steel containment vessel inside a concrete shield building. In the event of a pipe break inside containment, a high pressure signal actuates valves which allow water to drain from a storage tank atop the shield building. Water is applied to the top of the containment shell, and evaporates, thereby removing heat. An air flow path is formed between the shield building and the containment to aid in the evaporation and is exhausted through a chimney at the top of the shield building. Extensive testing and analysis of this system was performed as part of the AP600 design certification process. The AP1000 containment has been designed to provide increased safety margin despite the increased reactor power. The containment volume was increased to accommodate the larger steam generators, and to provide increased margin for containment pressure response to design basis events. The containment design pressure was increased from AP600 by increasing the shell thickness and by utilizing high strength steel. The passive containment cooling system water capacity has been increased and the water application rate has been scaled to the higher decay heat level. The net result is higher margins to the containment design pressure limit than were calculated for AP600 for all design basis events. (authors)

Safeguarding and Protecting Children in Maternity Services: Implications for Practice

Science.gov (United States)

Lazenbatt, Anne; Greer, Jean

2009-01-01

This article debates the issues involved in safeguarding and protecting children in maternity services and offers implications for professional practice. Midwives and other staff who work as members of the maternity team have a safeguarding role to play in the identification of babies and children who have been abused, or are at risk of abuse, and…

Identification and treatment of APS renal involvement.

Science.gov (United States)

Tektonidou, M G

2014-10-01

Renal involvement in antiphospholipid syndrome (APS), either primary or systemic lupus erythematosus (SLE)-related APS, includes renal artery stenosis or thrombosis, renal infarction, renal vein thrombosis and a small-vessel vaso-occlusive nephropathy defined as "antiphospholipid antibody (aPL)-associated nephropathy." aPL-associated nephropathy is characterized by acute lesions, thrombotic microangiopathy, and chronic lesions such as fibrous intimal hyperplasia, organizing thrombi with or without recanalization, fibrous occlusions of arteries or arterioles and focal cortical atrophy. Systemic hypertension, hematuria, proteinuria (ranging from mild to nephrotic level) and renal insufficiency represent the major clinical manifestations associated with aPL-associated nephropathy. Similar renal histologic and clinical characteristics have been described among all different groups of patients with positive aPL (primary APS, SLE-related APS, catastrophic APS and SLE/non-APS with positive aPL). In patients with aPL-associated nephropathy lesions in the absence of other causes associated with similar histological characteristics, aPL testing needs to be considered. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Raising the acceptance of the AP2-line

International Nuclear Information System (INIS)

Trbojevic, D.

1989-01-01

The 120 GeV Main Ring proton beam collides with the target at the end of the AP-1 line and creates antiprotons and other secondary particles. The AP-2 line transfers the negative particles from the target to the Debuncher. To provide a bigger antiproton stack size in the Accumulator, both the Debuncher as well as the AP-2 line acceptance have to be raised. This is a proposal for the improvement of the AP-2 line acceptance. The first part of the memo presents an acceptance examination of the existing AP-2 line by computer simulation, while the second presents a short proposal for aperture corrections. The computer program TURTLE was used to trace antiprotons through the AP-2 line without taking into account other negative charged particles. Betatron functions were obtained from the output of the SYNCH computer program. The SYNCH program was also used to check the dispersion match between the AP-2 line and the Debuncher. 3 refs., 6 figs., 5 tabs

Development of a superconducting undulator for the APS

International Nuclear Information System (INIS)

Ivanyushenkov, Y; Abliz, M; Doose, C; Fuerst, J; Hasse, Q; Kasa, M; Trakhtenberg, E; Vasserman, I; Gluskin, E; Lev, V; Mezentsev, N; Syrovatin, V; Tsukanov, V

2013-01-01

As the western hemisphere's premier x-ray synchrotron radiation source, the Advanced Photon Source (APS) continues to advance the state of the art in insertion device technology in order to maintain record high brightness, especially in the hard x-ray wavelength region. Due to the unique bunch pattern used for normal APS operations and its ultimate capabilities, the APS has chosen superconducting technology for its future hard x-ray undulator sources. In the last several years, the APS in collaboration with the Budker Institute of Nuclear Physics has being developing the technology for planar, small-period superconducting undulators (SCUs). These developments include the design and construction of several prototypes and the construction of the necessary mechanical, vacuum, and cryogenic infrastructure at the APS site. Several prototypes of the SCU magnetic structure have been built and tested. The first SCU is assembled and will be installed in the APS storage ring at the end of 2012. Expected SCU performance in terms of x-ray brightness should noticeably exceed that of existing APS undulators. Immediately after commissioning, the SCU will be used at APS Sector 6 as the radiation source for high-energy x-ray studies.

Comparison of Spectral and Scintillation Properties of LuAP:Ce and LuAP:Ce,Sc Single Crystals

Science.gov (United States)

Petrosyan, Ashot G.; Derdzyan, Marina; Ovanesyan, Karine; Shirinyan, Grigori; Lecoq, Paul; Auffray, Etiennette; Kronberger, Matthias; Frisch, Benjamin; Pedrini, Christian; Dujardin, Christophe

2009-10-01

Scintillation properties of LuAP:Ce and LuAP:Ce,Sc crystal series were studied under excitation by gamma-rays from a 137Cs source. Both series demonstrated comparable optical quality in terms of underlying absorption at 260 nm, slope of the optical edge and transmission in the range of emission. The light yield of LuAP:Ce crystals measured in 0.2 cm times 0.2 cm times 0.8 cm pixels increases linearly with the Ce concentration reaching at 0.58 at. % 6448 plusmn 322 ph/MeV and 9911 plusmn 496 ph/MeV in the long and in the short directions respectively (the light yield ratio is 65%) and shows no sign of light saturation. The energy resolution is found to depend, among other factors, on the uniformity of Ce concentration within the pixels and is improved to 7.1 plusmn 0.4% (I = 0.2 cm), 9.5 plusmn 0.5% (I = 0.8 cm). Intentional co-doping with Sc + ions was tested and resulted in increase of the Ce distribution coefficient to about 0.3. This enabled to increase the concentration of Ce in LuAP:Ce,Sc crystals up to 0.7 at. %, while conserving high optical quality. In contrast to LuAP:Ce, the light yield in LuAP:Ce,Sc crystals does not increase with Ce concentration, the photo peak being gradually suppressed. The involved mechanisms are discussed basing on measurements of the unit cell volumes, Ce concentration uniformity, x-ray rocking spectra, absorption spectra of pure and variously doped LuAP crystals, and emission spectra under different excitations.

DOPA, a Digital Observatory for Protected Areas including Monitoring and Forecasting Services

Science.gov (United States)

Dubois, Gregoire; Hartley, Andrew; Peedell, Stephen; de Jesus, Jorge; Ó Tuama, Éamonn; Cottam, Andrew; May, Ian; Fisher, Ian; Nativi, Stefano; Bertrand, Francis

2010-05-01

The Digital Observatory for Protected Areas (DOPA) is a biodiversity information system currently developed as an interoperable web service at the Joint Research Centre of the European Commission in collaboration with other international organizations, including GBIF, UNEP-WCMC, Birdlife International and RSPB. DOPA is designed to assess the state and pressure of Protected Areas (PAs) and to prioritize them accordingly, in order to support decision making and fund allocation processes. To become an operational web service allowing the automatic monitoring of protected areas, DOPA needs to be able to capture the dynamics of spatio-temporal changes in habitats and anthropogenic pressure on PAs as well as the changes in the species distributions. Because some of the most valuable natural ecosystems and species on the planet cover large areas making field monitoring methods very difficult for a large scale assessment, the automatic collection and processing of remote sensing data are processes at the heart of the problem. To further be able to forecast changes due to climate change, DOPA has to rely on an architecture that enables it to communicate with the appropriate modeling web services. The purpose of this presentation is to present the architecture of the DOPA with special attention to e-Habitat, its web processing service designed for assessing the irreplaceability of habitats as well as for the modeling of habitats under different climate change scenarios. The use of open standards for spatial data and of open source programming languages for the development of the core functionalities of the system are expected to encourage the participation of the scientific community beyond the current partnerships and to favour the sharing of such an observatory which could be installed at any other location. Acknowledgement: Part of this work is funded under the 7th Framework Programme by the EuroGEOSS (www.eurogeoss.eu) project of the European Commission. The views

Test methods for protective footwear against AP mine blast

NARCIS (Netherlands)

Cronin, D.S.; Williams, K.; Bass, C.R.; Magnan, P.; Dosquet, F.; Bergeron, D.M.; Bree, J.L.M.J. van

2003-01-01

The testing and development of protective footwear for anti-personnel landmine blast threats is of great importance to civilian and military deminers, and peacekeepers. This study will review the wide range of test methods that have been developed by NATO countries to test footwear against the

Suggestion on Information Sharing for AP implementation

Energy Technology Data Exchange (ETDEWEB)

Shim, Hye Won; Kim, Min Su; Koh, Byung Marn [Korea Institute of Nuclear Nonproliferation and Control, Daejeon (Korea, Republic of)

2013-10-15

Under the Additional Protocol, States should provide the IAEA with expanded declarations of activities related to the nuclear fuel cycle and other nuclear activities, and with expanded access to the relevant information and sites to allow the IAEA to verify the completeness of these declarations. The AP to the Safeguards Agreement (the Additional Protocol) was signed on June 21{sup st}, 1999 and entered into force on February 19{sup th}, 2004. ROK submitted initial declarations in August 2004. Since then, ROK has been submitting annual updated reports of initial declaration on every May 15{sup th}. To achieve successful implementation, it is necessary to collect the information for each individual article in Article 2 of the AP and verify the declared information provided by facility operators. Therefore, the cooperation among the ministries and offices concerned is a prerequisite for successful implementation of AP. Unfortunately, the formal procedure for inter-organizational information sharing and cooperation is not established. This paper will briefly outline the AP declarations and suggest the information sharing among the ministries, offices and organizations for effective and efficient implementation of AP. The State authority has responsibility for AP implementation and it should verify correctness and completeness of the information declared by facility operators before submitting the declarations. The close cooperation and information sharing among the ministries, offices and organizations are indispensable to effective and efficient implementation of AP.

Operation of the APS rf gun

International Nuclear Information System (INIS)

Lewellen, J. W.

1998-01-01

The Advanced Photon Source (APS) has a thermionic-cathode rf gun system capable of providing beam to the APS linac. The gun system consists of a 1.6-cell thermionic-cathode rf gun, a fast kicker for beam current control, and an alpha magnet for bunch compression and injection into the APS linac line. This system is intended for use both as an injector for positron creation, and as a first beam source for the Low-Energy Undulator Test Line (LEUTL) project [1]. The first measured performance characteristics of the gun are presented.

The Ped-APS Registry: the antiphospholipid syndrome in childhood.

Science.gov (United States)

Avcin, T; Cimaz, R; Rozman, B

2009-09-01

In recent years, antiphospholipid syndrome (APS) has been increasingly recognised in various paediatric autoimmune and nonautoimmune diseases, but the relatively low prevalence and heterogeneity of APS in childhood made it very difficult to study in a systematic way. The project of an international registry of paediatric patients with APS (the Ped-APS Registry) was initiated in 2004 to foster and conduct multicentre, controlled studies with large number of paediatric APS patients. The Ped-APS Registry is organised as a collaborative project of the European Forum on Antiphospholipid Antibodies and Juvenile Systemic Lupus Erythematosus Working Group of the Paediatric Rheumatology European Society. Currently, it documents a standardised clinical, laboratory and therapeutic data of 133 children with antiphospholipid antibodies (aPL)-related thrombosis from 14 countries. The priority projects for future research of the Ped-APS Registry include prospective enrollment of new patients with aPL-related thrombosis, assessment of differences between the paediatric and adult APS, evaluation of proinflammatory genotype as a risk factor for APS manifestations in childhood and evaluation of patients with isolated nonthrombotic aPL-related manifestations.

Ecosystem services in a peri-urban protected area in Cyprus: a rapid appraisal

Directory of Open Access Journals (Sweden)

Paraskevi Manolaki

2017-10-01

Full Text Available Protected areas around the world are increasingly being recognized for their potential to protect various ecosystem services in addition to biodiversity. We carried out an ecosystem services (ES assessment at the Rizoelia National Forest Park, a biodiversity hotspot in Cyprus. For ES assessment we used TESSA v.1.1 and an ES matrix-approach to map the capacity of habitat types in the area. According to TESSA the most important ES provided by the study area are aesthetic benefits, recreation/ tourism, biodiversity, global climate regulation, and environmental education. Total Carbon stock was estimated to 14247.327 tonnes and the total number of annual visits was 14471. There were no statistically significant differences in the number of visits among visitation periods but there were statistically significant differences among National Holidays, Weekends and Weekdays. We identified that plantations had the highest capacity for most groups of services particularly where their understory comprises semi-natural habitat types rich in biodiversity. This is the first study in Cyprus which provides a preliminary quantification of ES in a protected area context using widely employed tools. The paper discusses how these findings can help decision-makers to plan direct future restoration and management actions to the benefit of a wide range of stakeholders.

Effect of oxygen and nitroaromatic cell radiosensitizers on radiation-induced cleavage of internucleotide bonds: ApA, dApA, and poly(A)

International Nuclear Information System (INIS)

Raleigh, J.A.; Kremers, W.; Whitehouse, R.

1975-01-01

Irradiation of the dinucleoside monophosphates ApA and dApA in deoxygenated solution leads to a preferential cleavage of the 3' end of the internucleotide bond. Cleavage at the 3' bond is favored to the extent of 2 to 1 over 5' cleavage. Oxygen and nitroaromatic compounds inhibit 3' bond breaking in ApA and dApA in agreement with earlier findings from studies of 3'- and 5'-mononucleotides. In contrast to the mononucleotide results, no enhancement of 5' cleavage is observed for ApA and dApA irradiated in the presence of oxygen or the nitroaromatic additives. The over-all effect of the additives is to decrease the combined (3' and 5') yield of internucleotide bond breaking in ApA and dApA. This phenomenon is also observed for polyadenylic acid in the presence of the nitroaromatics. Oxygen marginally enhances internucleotide bond breaking in polyadenylic acid (factor 1.1) over that seen in deoxygenated solution. Postirradiation alkaline hydrolysis of dApA leads to further ester cleavage revealing the presence of radiation-induced alkali-labile bonds. The number of these bonds decreases in the order oxygen greater than nitrofurans greater than nitrobenzenes approximately irradiation in the absence of additives

APS beamline standard components handbook

International Nuclear Information System (INIS)

Kuzay, T.M.

1992-01-01

It is clear that most Advanced Photon Source (APS) Collaborative Access Team (CAT) members would like to concentrate on designing specialized equipment related to their scientific programs rather than on routine or standard beamline components. Thus, an effort is in progress at the APS to identify standard and modular components of APS beamlines. Identifying standard components is a nontrivial task because these components should support diverse beamline objectives. To assist with this effort, the APS has obtained advice and help from a Beamline Standardization and Modularization Committee consisting of experts in beamline design, construction, and operation. The staff of the Experimental Facilities Division identified various components thought to be standard items for beamlines, regardless of the specific scientific objective of a particular beamline. A generic beamline layout formed the basis for this identification. This layout is based on a double-crystal monochromator as the first optical element, with the possibility of other elements to follow. Pre-engineering designs were then made of the identified standard components. The Beamline Standardization and Modularization Committee has reviewed these designs and provided very useful input regarding the specifications of these components. We realize that there will be other configurations that may require special or modified components. This Handbook in its current version (1.1) contains descriptions, specifications, and pre-engineering design drawings of these standard components. In the future, the APS plans to add engineering drawings of identified standard beamline components. Use of standard components should result in major cost reductions for CATs in the areas of beamline design and construction

Confidentiality Protection of User Data and Adaptive Resource Allocation for Managing Multiple Workflow Performance in Service-Based Systems

Science.gov (United States)

An, Ho

2012-01-01

In this dissertation, two interrelated problems of service-based systems (SBS) are addressed: protecting users' data confidentiality from service providers, and managing performance of multiple workflows in SBS. Current SBSs pose serious limitations to protecting users' data confidentiality. Since users' sensitive data is sent in…

IPPAS guidelines. Reference document for the IAEA International Physical Protection Advisory Service

International Nuclear Information System (INIS)

1999-01-01

The IAEA International Physical protection Advisory Service (IPPAS) provides advice to Member States to assist them in strengthening the effectiveness of their national physical protection system whilst recognizing the ultimate responsibility for physical protection is that of the Member State. The IPPAS is available to all countries with nuclear materials and facilities. The basic concepts, purposes and functions of physical protection are provided in INFCIR/225, 'The Physical Protection of Nuclear Material and Nuclear Facilities' as amended from time to time and 'the Convention on the Physical Protection of Nuclear Material (INFCIR/247/Rev.1). The guidance given in INFCIR/225 recognizes that implementation of these requirements vary from country to country depending on their existing constitutional, legal and administrative systems; the assessment of the threat for the potential theft of nuclear material or sabotage of nuclear facilities; the technical skills and professional and financial resources available to the competent authority; and social customs and cultural traditions. IPPAS missions are performance oriented in that they accept different approaches to the implementation of national physical protection system

Roles of AP-2 in clathrin-mediated endocytosis.

Directory of Open Access Journals (Sweden)

Emmanuel Boucrot

2010-05-01

Full Text Available The notion that AP-2 clathrin adaptor is an essential component of an endocytic clathrin coat appears to conflict with recent observations that substantial AP-2 depletion, using RNA interference with synthesis of AP-2 subunits, fails to block uptake of certain ligands known to internalize through a clathrin-based pathway.We report here the use of in vivo imaging data obtained by spinning-disk confocal microscopy to study the formation of clathrin-coated structures at the plasma membranes of BSC1 and HeLa cells depleted by RNAi of the clathrin adaptor, AP-2. Very few clathrin coats continue to assemble after AP-2 knockdown. Moreover, there is a total absence of clathrin-containing structures completely lacking AP-2 while all the remaining coats still contain a small amount of AP-2. These observations suggest that AP-2 is essential for endocytic coated-pit and coated-vesicle formation. We also find that AP-2 knockdown strongly inhibits light-density lipoprotein (LDL receptor-mediated endocytosis, as long as cells are maintained in complete serum and at 37 degrees C. If cells are first incubated with LDL at 4 degrees C, followed by warming, there is little or no decrease in LDL uptake with respect to control cells. LDL uptake at 37 degrees C is also not affected in AP-2 depleted cells first deprived of LDL by incubation with either serum-starved or LDL-starved cells for 24 hr. The LDL-deprived cells display a significant increase in endocytic structures enriched on deeply invaginated tubes that contain LDL and we suggest that under this condition of stress, LDL might enter through this alternative pathway.These results suggest that AP-2 is essential for endocytic clathrin coated-pit and coated-vesicle formation. They also indicate that under normal conditions, functional endocytic clathrin coated pits are required for LDL internalization. We also show that under certain conditions of stress, cells can upregulate alternative endocytic structures

Impact of payments for environmental services and protected areas on local livelihoods and forest conservation in northern Cambodia

Science.gov (United States)

Clements, Tom; Milner-Gulland, E J

2015-01-01

The potential impacts of payments for environmental services (PES) and protected areas (PAs) on environmental outcomes and local livelihoods in developing countries are contentious and have been widely debated. The available evidence is sparse, with few rigorous evaluations of the environmental and social impacts of PAs and particularly of PES. We measured the impacts on forests and human well-being of three different PES programs instituted within two PAs in northern Cambodia, using a panel of intervention villages and matched controls. Both PES and PAs delivered additional environmental outcomes relative to the counterfactual: reducing deforestation rates significantly relative to controls. PAs increased security of access to land and forest resources for local households, benefiting forest resource users but restricting households’ ability to expand and diversify their agriculture. The impacts of PES on household well-being were related to the magnitude of the payments provided. The two higher paying market-linked PES programs had significant positive impacts, whereas a lower paying program that targeted biodiversity protection had no detectable effect on livelihoods, despite its positive environmental outcomes. Households that signed up for the higher paying PES programs, however, typically needed more capital assets; hence, they were less poor and more food secure than other villagers. Therefore, whereas the impacts of PAs on household well-being were limited overall and varied between livelihood strategies, the PES programs had significant positive impacts on livelihoods for those that could afford to participate. Our results are consistent with theories that PES, when designed appropriately, can be a powerful new tool for delivering conservation goals whilst benefiting local people. El Impacto de los Pagos por Servicios Ambientales y Áreas Protegidas sobre la Subsistencia Local y la Conservación del Bosque en el Norte de Camboya Resumen Los impactos

AP English language & composition crash course

CERN Document Server

Hogue, Dawn

2012-01-01

AP English Language & Composition Crash Course - Gets You a Higher Advanced Placement Score in Less Time Crash Course is perfect for the time-crunched student, the last-minute studier, or anyone who wants a refresher on the subject. AP English Language & Composition Crash Course gives you: Targeted, Focused Review - Study Only What You Need to Know Crash Course is based on an in-depth analysis of the AP English Language & Composition course description outline and actual Advanced Placement test questions. It covers only the information tested on the exam, so you can make the most of your valua

The privacy concerns in location based services: protection approaches and remaining challenges

OpenAIRE

Basiri, Anahid; Moore, Terry; Hill, Chris

2016-01-01

Despite the growth in the developments of the Location Based Services (LBS) applications, there are still several challenges remaining. One of the most important concerns about LBS, shared by many users and service providers is the privacy. Privacy has been considered as a big threat to the adoption of LBS among many users and consequently to the growth of LBS markets. This paper discusses the privacy concerns associated with location data, and the current privacy protection approaches. It re...

Religião, política e ordem social nos Atos Apócrifos dos Apóstolos

Directory of Open Access Journals (Sweden)

José Adriano Filho

2016-01-01

Full Text Available Os Atos Apócrifos dos Apóstolos recontam a tradição dos apóstolos e suas façanhas públicas. Os apóstolos são apresentados em constante conflito com o mundo à sua volta. Eles demonstram o poder do único Deus verdadeiro por meio de milagres, ascetismo e martírio. O cristianismo que eles representam contrasta com as crenças e poder do mundo greco-romano. Esta instância antissocial é reforçada pela mensagem de castidade anunciada pelos apóstolos, a qual interrompe o casamento, e nos conflitos com as autoridades civis e religiosas. Eles têm preocupações apologéticas, missionárias e de edificação, mas rejeitam os ideais culturais e sociais tradicionais em favor de novos ideais. Os Atos Apócrifos também refletem a rede do patronato social e político contemporâneo do Império romano. Eles redefinem o patronato de uma perspectiva cristã e desafiam o sistema estabelecido ao apresentar a Cristo como o verdadeiro patrono, superior aos patronos humanos, incluindo o imperador. A tentativa de reformular as pressuposições estabelecidas é uma característica que define a identidade cristã representada nesta literatura.

Achieving sustainable ese of environment: a framework for payment for protected forest ecosystem service

Science.gov (United States)

Widicahyono, A.; Awang, S. A.; Maryudi, A.; Setiawan, M. A.; Rusdimi, A. U.; Handoko, D.; Muhammad, R. A.

2018-04-01

Over the last decade, deforestation in Indonesia has reduced the forest area down to more than 6 million hectares. There is conflict that the protected forest ecosystem service is still often perceived as public goods. Many of them went unrecognized in planning process and continue to be undervalued. The challenge lies in maintaining socioeconomic development and ecosystem services sustainability without overlooking the people’s opportunities and improving their livelihoods over the long term. An integrated approach is required to understand the comprehensive concept of protected forest ecosystem service. This research aims to formulate a scheme of payment for ecosystem service (PES) in a protected forest. It is a first step towards the attempt for the value of ecosystem services to be reflected in decision-making. Literatures, previous researches and secondary data are reviewed thoroughly to analyze the interrelated components by looking at the environment as a whole and recognize their linkages that have consequences to one another both positive and negative. The framework of implementation of PES schemes outlines the complexity of human-environment interconnecting relationships. It evaluates the contributing actors of different interest i.e. long term use and short term use. The concept of PES accommodates the fulfillment of both conservation and exploitation with an incentive scheme to the contributing parties who are willing to implement conservation and issuance of compensation expense for any exploitation means. The most crucial part in this concept is to have a good and effective communication between every policy makers concerning the forest ecosystem and local communities.

Hanford radiological protection support services annual report 1996

International Nuclear Information System (INIS)

Lyon, M.; Bihl, D.E.; Fix, J.J.; Froelich, T.J.; Piper, R.K.; Schulze, S.A.

1997-06-01

Various Hanford Site radiation protection services provided by the Pacific Northwest National Laboratory for the US Department of Energy Richland Operations Office and Hanford contractors are described in this annual report for calendar year 1996. These activities include external dosimetry measurements and evaluations, internal dosimetry measurements and evaluations, in vivo measurements, radiological exposure record keeping, radiation source calibration, and instrument calibration and evaluation. For each of these activities, the routine program and any program changes or enhancements are described, as well as associated tasks, investigations, and studies. Program-related publications, presentations, and other staff professional activities are also described

Strategy of protected areas development in purposes of using and keeping bioresources and ecosystem services

Directory of Open Access Journals (Sweden)

Tatiana Vyacheslavovna Tikhonova

2012-09-01

Full Text Available Features and condition of existing system of especially protected natural territories of the Komi Republic are presented in this paper. Their specific environmental problems are defined. Strong sides and weaknesses of functioning and management of objects of special protection are provided. For approbation of a complex of methods of steady exploitation of this territory modeling objects of special protection are allocated and the economic assessment is carried out them. Potential recipients of benefits from use of bioresources and ecosystem services on modeling objects arerevealed. Theterritories possessing a reservefor increasein use of their resources and services are presented. Offers on strategy of development of a control system of especially protected natural territories of the Komi Republic are developed. Development strategy of control system ofespecially protected natural territories is consisting of someinstitutional decisions. This acceptance of federal-regional agreement about management control;creating of regional rules, which regulatethe usage of natural resources in especially protected natural territories; application of an integrated approach to the use of territories, which provide the bases to increase recreation and tourist industry; transfer buffer zone territories to biosphere reservation.

Proactive AP Selection Method Considering the Radio Interference Environment

Science.gov (United States)

Taenaka, Yuzo; Kashihara, Shigeru; Tsukamoto, Kazuya; Yamaguchi, Suguru; Oie, Yuji

In the near future, wireless local area networks (WLANs) will overlap to provide continuous coverage over a wide area. In such ubiquitous WLANs, a mobile node (MN) moving freely between multiple access points (APs) requires not only permanent access to the Internet but also continuous communication quality during handover. In order to satisfy these requirements, an MN needs to (1) select an AP with better performance and (2) execute a handover seamlessly. To satisfy requirement (2), we proposed a seamless handover method in a previous study. Moreover, in order to achieve (1), the Received Signal Strength Indicator (RSSI) is usually employed to measure wireless link quality in a WLAN system. However, in a real environment, especially if APs are densely situated, it is difficult to always select an AP with better performance based on only the RSSI. This is because the RSSI alone cannot detect the degradation of communication quality due to radio interference. Moreover, it is important that AP selection is completed only on an MN, because we can assume that, in ubiquitous WLANs, various organizations or operators will manage APs. Hence, we cannot modify the APs for AP selection. To overcome these difficulties, in the present paper, we propose and implement a proactive AP selection method considering wireless link condition based on the number of frame retransmissions in addition to the RSSI. In the evaluation, we show that the proposed AP selection method can appropriately select an AP with good wireless link quality, i.e., high RSSI and low radio interference.

Client Violence and Its Negative Impacts on Work Attitudes of Child Protection Workers Compared to Community Service Workers

Science.gov (United States)

Shin, Junseob

2011-01-01

This study investigated the prevalence of client violence toward child protection workers and its negative impacts on the work attitudes of those workers compared with community service workers in South Korea. This study is based on the assumption that child protection workers are more vulnerable to violence than are community service workers…

Westinghouse AP1000 advanced passive plant: design features and benefits

International Nuclear Information System (INIS)

Walls, S.J.; Cummins, W.E.

2003-01-01

The Westinghouse AP1000 Program is aimed at implementing the AP1000 plant to provide a further major improvement in plant economics while maintaining the passive safety advantages established by the AP600. An objective is to retain to the maximum extent possible the plant design of the AP600 so as to retain the licensing basis, cost estimate, construction schedule, modularization scheme, and the detailed design from the AP600 program. Westinghouse and the US Nuclear Regulatory Commission staff have embarked on a program to complete Design Certification for the AP1000 by 2004. A pre-certification review phase was completed in March 2002 and was successful in establishing the applicability of the AP600 test program and AP600 safety analysis codes to the AP1000 Design Certification. On March 28, 2002, Westinghouse submitted to US NRC the AP1000 Design Control Document and Probabilistic Risk Assessment, thereby initiating the formal design certification review process. The results presented in these documents verify the safety performance of the API 000 and conformance with US NRC licensing requirements. Plans are being developed for implementation of a series of AP1000 plants in the US. Key factors in this planning are the economics of AP1000, and the associated business model for licensing, constructing and operating these new plants. Similarly plans are being developed to get the AP1000 design reviewed for use in the UK. Part of this planning has been to examine the AP1000 design relative to anticipated UK safety and licensing issues. (author)

Mitochondrial Protection and Anti-aging Activity of Astragalus Polysaccharides and Their Potential Mechanism

Directory of Open Access Journals (Sweden)

Xiao-Juan Xin

2012-02-01

Full Text Available The current study was performed to investigate mitochondrial protection and anti-aging activity of Astragalus polysaccharides (APS and the potential underlying mechanism. Lipid peroxidation of liver and brain mitochondria was induced by Fe2+–Vit C in vitro. Thiobarbituric acid (TBA colorimetry was used to measure the content of thiobarbituric acid reactive substances (TBARS. Mouse liver mitochondrial permeability transition (PT was induced by calcium overload in vitro and spectrophotometry was used to measure it. The scavenging activities of APS on superoxide anion (O2•－ and hydroxyl radical (•OH, which were produced by reduced nicotinamide adenine dinucleotide (NADH—N-Methylphenazonium methyl sulfate (PMS and hydrogen peroxide (H2O2–Fe2+ system respectively, were measured by 4-nitrobluetetrazolium chloride (NBT reduction and Fenton reaction colorimetry respectively. The Na2S2O3 titration method was used to measure the scavenging activities of APS on H2O2. APS could inhibit TBARS production, protect mitochondria from PT, and scavenge O2•－, •OH and H2O2 significantly in a concentration-dependent manner respectively. The back of the neck of mice was injected subcutaneously with D-galactose to induce aging at a dose of 100 mg/kg/d for seven weeks. Moreover, the activities of catalase (CAT, surperoxide dismutase (SOD and glutathione peroxidase (GPx and anti-hydroxyl radical which were assayed by using commercial monitoring kits were increased significantly in vivo by APS. According to this research, APS protects mitochondria by scavenging reactive oxygen species (ROS, inhibiting mitochondrial PT and increasing the activities of antioxidases. Therefore, APS has the effect of promoting health.

Market analysis of APS/SCM applications and technologies

OpenAIRE

Prášil, Zdeněk

2009-01-01

The bachelor thesis aims to describe a current worldwide market of APS/SCM technologies and applications , i.e. advanced planned scheduling /supply chain management. In the first part, the APS/SCM is described in theory. The APS/SCM is defined and its benefits and impacts on company are discussed. The next part of the work is focused on the market with APS/SCM and the distribution of forces in the market. The demand and supply of this market segment is analyzed. In the last part, solutions of...

AP Human Geography and Success on the AP Test

Science.gov (United States)

Roncone, John; Newhalfen, Nate

2013-01-01

Classroom projects that explore culture and globalization enhance the curriculum and help students see how geography directly connects to their lives. These authors contend that a project-based approach can supplement the teaching of an AP Human Geography course, and visualize this course as an essential tool for students to truly understand how…

Confirmatory analysis of the AP1000 passive residual heat removal heat exchanger with 3-D computational fluid dynamic analysis

International Nuclear Information System (INIS)

Schwall, James R.; Karim, Naeem U.; Thakkar, Jivan G.; Taylor, Creed; Schulz, Terry; Wright, Richard F.

2006-01-01

The AP1000 is an 1100 MWe advanced nuclear power plant that uses passive safety features to enhance plant safety and to provide significant and measurable improvements in plant simplification, reliability, investment protection and plant costs. The AP1000 received final design approval from the US-NRC in 2004. The AP1000 design is based on the AP600 design that received final design approval in 1999. Wherever possible, the AP1000 plant configuration and layout was kept the same as AP600 to take advantage of the maturity of the design and to minimize new design efforts. As a result, the two-loop configuration was maintained for AP1000, and the containment vessel diameter was kept the same. It was determined that this significant power up-rate was well within the capability of the passive safety features, and that the safety margins for AP1000 were greater than those of operating PWRs. A key feature of the passive core cooling system is the passive residual heat removal heat exchanger (PRHR HX) that provides decay heat removal for postulated LOCA and non-LOCA events. The PRHR HX is a C-tube heat exchanger located in the in-containment refueling water storage tank (IRWST) above the core promoting natural circulation heat removal between the reactor cooling system and the tank. Component testing was performed for the AP600 PRHR HX to determine the heat transfer characteristics and to develop correlations to be used for the AP1000 safety analysis codes. The data from these tests were confirmed by subsequent integral tests at three separate facilities including the ROSA facility in Japan. Owing to the importance of this component, an independent analysis has been performed using the ATHOS-based computational fluid dynamics computer code PRHRCFD. Two separate models of the PRHR HX and IRWST have been developed representing the ROSA test geometry and the AP1000 plant geometry. Confirmation of the ROSA test results were used to validate PRHRCFD, and the AP1000 plant model

The institutionalization of children's participation in a child protective service

OpenAIRE

Compte Nunes, Guillem

2015-01-01

[EN] In order to advance toward an understanding of the mechanisms of social transformation, overcoming the rhetoric about the importance of children’s participation and the marginalization of the knowledge on children’s issues, this paper identifies facilitating factors for and barriers against the institutionalization of children’s participation in a public child protective service. The results are interpreted through the 4I model of organizational learning. They highlight th...

Westinghouse AP600 advanced nuclear plant design

International Nuclear Information System (INIS)

Gangloff, W.

1999-01-01

As part of the cooperative US Department of Energy (DOE) Advanced Light Water Reactor (ALWR) Program and the Electric Power Research Institute (EPRI), the Westinghouse AP600 team has developed a simplified, safe, and economic 600-megawatt plant to enter into a new era of nuclear power generation. Designed to satisfy the standards set by DOE and defined in the ALWR Utility Requirements Document (URD), the Westinghouse AP600 is an elegant combination of innovative safety systems that rely on dependable natural forces and proven technologies. The Westinghouse AP600 design simplifies plant systems and significant operation, inspections, maintenance, and quality assurance requirements by greatly reducing the amount of valves, pumps, piping, HVAC ducting, and other complex components. The AP600 safety systems are predominantly passive, depending on the reliable natural forces of gravity, circulation, convection, evaporation, and condensation, instead of AC power supplies and motor-driven components. The AP600 provides a high degree of public safety and licensing certainty. It draws upon 40 years of experience in light water reactor components and technology, so no demonstration plant is required. During the AP600 design program, a comprehensive test program was carried out to verify plant components, passive safety systems components, and containment behavior. When the test program was completed at the end of 1994, the AP600 became the most thoroughly tested advanced reactor design ever reviewed by the US Nuclear Regulatory Commission (NRC). The test results confirmed the exceptional behavior of the passive systems and have been instrumental in facilitating code validations. Westinghouse received Final Design Approval from the NRC in September 1998. (author)

NF-κB/AP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton

Directory of Open Access Journals (Sweden)

Van Thai Ha

2014-01-01

Full Text Available AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression. Since macrophage-mediated inflammatory responses are critical for skin health, here we investigated the potential anti-inflammatory activity of AP736. The effects of AP736 on various inflammatory events such as nitric oxide (NO/prostaglandin (PG E2 production, inflammatory gene expression, phagocytic uptake, and morphological changes were examined in RAW264.7 cells. AP736 was found to strongly inhibit the production of both NO and PGE2 in lipopolysaccharide- (LPS- treated RAW264.7 cells. In addition, AP736 strongly inhibited both LPS-induced morphological changes and FITC-dextran-induced phagocytic uptake. Furthermore, AP736 also downregulated the expression of multiple inflammatory genes, such as inducible NO synthase (iNOS, cyclooxygenase- (COX- 2, and interleukin- (IL- 1β in LPS-treated RAW264.7 cells. Transcription factor analysis, including upstream signalling events, revealed that both NF-κB and AP-1 were targeted by AP736 via inhibition of the IKK/IκBα and IRAK1/TAK1 pathways. Therefore, our results strongly suggest that AP736 is a potential anti-inflammatory drug due to its suppression of NF-κB-IKK/IκBα and AP-1-IRAK1/TAK1 signalling, which may make AP736 useful for the treatment of macrophage-mediated skin inflammation.

Ten years of a National Service of Dosimetric calibration at radiation protection

International Nuclear Information System (INIS)

Morales, J.A.; Jova, L.; Hernandez, E.; Campa, R.; Walwyn, G.

1996-01-01

Since 1986, the CPHR has offered a national service of calibration of dosimetric instruments at levels of radiation protection. The history of such a service is the chronology of efforts to reduce the uncertainties of the calibration process, expand the ranges of useful dose rates, and enhance the radiological safety when using the sources. The crowning of those efforts is the complement and start-up of the secondary la laboratory of dosimetric calibration (SLDC), which is currently a member of the IAEA/WHO. SLDC international network. As a result of this service, 256 instruments have been calibration and 867 personal dosimeters film badges and TLD and 72 environmental TLD dosimeters have been irradiated at known doses. The service rendered has benefited 62 national institutions which are users of ionizing radiations

Implementation of a radiation protection framework for medical and dental X-ray diagnostic services in Minas Gerais/Brazil

International Nuclear Information System (INIS)

Silva, Teogenes A. da; Pereira, Elton G.; Nogueira, Maria do S.; Ferreira, Hudson R.; Alonso, Thessa C.; Castro, Jose G.L. de; Andrade, Mauricio C.; Joana, Georgia S.; Oliveira, Mauricio de; Cezar, Adriana C. Z.

2008-01-01

The Brazilian Sanitary Vigilance Agency is the regulatory authority for radiation protection and quality control of all practices with X-rays for diagnostic purpose. In 1998, the technical regulation 'Guidelines for Radiation Protection in Medical and Dental Radiodiagnostic' was issued by the government that reflected the most updated policy recommended by the International Basic Safety Standards for Protection against Ionizing Radiation. To accomplish the objective of improving radiation protection conditions in the state of Minas Gerais, the Development Centre of Nuclear Technology (CDTN) and the Superintendence of Sanitary Vigilance (SVS) signed a formal cooperation agreement that included: an accreditation process for radiation protection professionals, a follow-up program of the services provided by those professionals, technical support from CDTN for audits carried out by SVS and training of SVS inspectors. Actions to improve and assure metrological reliability of the radiation measurements and special attention to mammography services were done. This paper provides details and results of the radiation protection framework for X-ray radiodiagnostic services in Minas Gerais; the success of the adopted model suggests that it can be used as a basic model to other regions. (author)

Children's Experiences of Domestic Violence: Developing an Integrated Response from Police and Child Protection Services

Science.gov (United States)

Stanley, Nicky; Miller, Pam; Richardson Foster, Helen; Thomson, Gill

2011-01-01

Police notifications of incidents of domestic violence to child protection services constitute an acknowledgement of the harm that domestic violence inflicts on children. However, these notifications represent a substantial demand on child welfare services and the outcomes for children and victims of domestic violence have been questioned. This…

Data Protection in Financial Technology Services (A Study in Indonesian Legal Perspective

Directory of Open Access Journals (Sweden)

Dian Purnama Anugerah

2018-01-01

Full Text Available The banking sector is facing a new competitor, namely Financial Technology (Fin-tech. Fin-tech itself can be described as an industry composed of companies using a new tech-nology and innovation with available resources in order to compete in the marketplace of tradi-tional financial institutions and intermediaries in the delivery of financial services. In Indonesia, Fin-tech has been widely developed since the past 3 years. Fin-tech faces a new challenge as a new service for financial consumer which adapts to new ways of living in modern digital tech-nology era. Basically, Fin-tech offers three main categories such as payment, personal finance, and financing. In financing application there are peer to peer financing, social crowd funding, and loan marketplace. All of these kinds of application have some issues in legal framework and data protection due to the use of communication technologies such as internet, social networks, Smartphone, massive use of data with the Big Data, connected objects, etc. The use of big data and those new technologies create new opportunities for these sectors, and this development also raises significant data protection concerns. This paper discusses two legal issues of Fin-tech, the legal aspect, and the data protection.

The Relationship between Sun Protection Policy and Associated Practices in a National Sample of Early Childhood Services in Australia

Science.gov (United States)

Ettridge, Kerry A.; Bowden, Jacqueline A.; Rayner, Joanne M.; Wilson, Carlene J.

2011-01-01

Limiting exposure to sunlight during childhood can significantly reduce the risk of skin cancer. This was the first national study to assess the sun protection policies and practices of early childhood services across Australia. It also examined the key predictors of services' sun protection practices. In 2007, 1017 respondents completed a…

Evaluation of the use of personal protective equipment in radiodiagnostic services in Sergipe

International Nuclear Information System (INIS)

Santos, Lucas R. dos; Oliveira, Celso A.; Silva, Fabio A.R.; Souza, Divanizia N.

2008-01-01

The theme ionizing radiation is frequently associated with danger. Therefore this subject induces to think about accessories to personal protection. These accessories can contain metal heavy (as example, lead) so that we have an efficient protection. Our analysis was done with the main objective of evidence that is not enough the radiodiagnostic services have personal protective equipment to disposal to the radiology technicians have an efficient protection, because the procedures with ionizing radiation will be safe only with the use accomplish of the security procedures and of adequate use and storing of personal protective equipment. In our analysis the accessories in question were the lead rubber X-ray protection aprons and thyroid gland protectors. We have tested these accessories through of a similar methodology utilized to checking the half-value layer of the X-ray units. It was investigated also the importance given to use of these accessories by the radiology technicians. (author)

K-AP: Generating specified K clusters by efficient Affinity Propagation

KAUST Repository

Zhang, Xiangliang; Wang, Wei; Nø rvå g, Kjetil; Sebag, Michè le

2010-01-01

and experimental validation, K-AP was shown to be able to directly generate K clusters as user defined, with a negligible increase of computational cost compared to AP. In the meanwhile, K-AP preserves the clustering quality as AP in terms of the distortion. K

Hanford radiological protection support services annual report for 1991

International Nuclear Information System (INIS)

Lyon, M.; Bihl, D.E.; Fix, J.J.; Piper, R.K.; Froelich, T.J.; Leonwich, J.A.; Lynch, T.P.

1992-07-01

Various Hanford sitewide radiation protection services provided by the Pacific Northwest Laboratory for the US Department of Energy, Richland Field Office and Hanford contractors are described In this annual report for calendar year 1991. These activities include internal dosimetry measurements and evaluations, in vivo measurements, external dosimetry measurements and evaluations, instrument calibration and evaluation, radiation source calibration, and radiological records keeping. For each of these activities, the routine program, program changes and enhancements, associated tasks, investigations and studies, and related publications, presentations, and other staff professional activities are discussed as applicable

Assessing impacts of intensified biomass production and biodiversity protection on ecosystem services provided by European forests

NARCIS (Netherlands)

Verkerk, P.J.; Mavsar, R.; Giergiczny, M.; Lindner, M.; Edwards, D.; Schelhaas, M.J.

2014-01-01

To develop viable strategies for intensifying the use of forest biomass and for increasing forest protection, impacts on ecosystem services need to be assessed. We investigated the biophysical and economic impacts of increased forest biomass production and biodiversity protection on forest ecosystem

OpenAPS Data Commons on Open Humans

OpenAIRE

Lewis, Dana M.; Ball, Madeleine

2017-01-01

Poster describing OpenAPS, Open Humans, and joint work creating a data commons for OpenAPS data in the Open Humans platform. Presented at the 2017 Sage Assembly Bionetworks Assembly and recipient of a Young Innovator/Investigator award.

Rich radioprotective profiles of two indigenous medicinal plants Andrographis paniculata (Ap) and Swertia chirata (Sc)

Energy Technology Data Exchange (ETDEWEB)

Tripathi, Rakshamani [V.B.S. Purvanchal University, Jaunpur (India); Mohan, H [Radiation Chemistry and Chemical Dynamics Division, Bhabha Atomic Research Centre, Mumbai (India); Kamat, J P [Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai (India)

2005-01-01

The extracts of two indigenous medicinal plants, Andrographis paniculata (Ap) and Swertia chirata (Sc) were selected to study if they could prevent generation of reactive oxygen species (ROS) during radiation exposure. Rat liver mitochondria exposed to {gamma}-radiation (450Gy) resulted significant oxidative damage as exemplified by enhanced formation in various lipid peroxidation products, conjugated dienes (CD), lipid hydroperoxide (LOOH), TBARS as well as hydroxylnonenals. Simultaneous addition of Ap or Sc (50 mg/ml) extracts during radiation could significantly reverse such damage. Extracts showed high reducing equivalents, phenolic contents and displayed high scavenging activity with superoxide and hydroxyl radicals. The pulse radiolysis studies exhibited high reactivity with ABTS. Based on these observation, the plant extracts, Andrographis paniculata and Swertia chirata may emerge as effective radioprotective agents, protecting cells from radiation-induced injury. (author)

Rich radioprotective profiles of two indigenous medicinal plants Andrographis paniculata (Ap) and Swertia chirata (Sc)

International Nuclear Information System (INIS)

Tripathi, Rakshamani; Mohan, H.; Kamat, J.P.

2005-01-01

The extracts of two indigenous medicinal plants, Andrographis paniculata (Ap) and Swertia chirata (Sc) were selected to study if they could prevent generation of reactive oxygen species (ROS) during radiation exposure. Rat liver mitochondria exposed to γ-radiation (450Gy) resulted significant oxidative damage as exemplified by enhanced formation in various lipid peroxidation products, conjugated dienes (CD), lipid hydroperoxide (LOOH), TBARS as well as hydroxylnonenals. Simultaneous addition of Ap or Sc (50 mg/ml) extracts during radiation could significantly reverse such damage. Extracts showed high reducing equivalents, phenolic contents and displayed high scavenging activity with superoxide and hydroxyl radicals. The pulse radiolysis studies exhibited high reactivity with ABTS. Based on these observation, the plant extracts, Andrographis paniculata and Swertia chirata may emerge as effective radioprotective agents, protecting cells from radiation-induced injury. (author)

Measurements of the Received Signal Level and Service Coverage Area at the IEEE 802.11 Access Point in the Building

Science.gov (United States)

Gunantara, N.; Sudiarta, P. K.; Prasetya, AAN A. I.; Dharma, A.; Gde Antara, I. N.

2018-04-01

Access point (AP) is part of a Wireless Local Access Network (WLAN) with its communications using WiFi. AP is used to transmit and receive data to users/clients. The ability of AP to serve users/clients depends on many factors. Moreover, if AP is applied in conditions inside the building. In this study, AP is installed at two points inside the building and then measured in the form of the received signal level (RSL) and service coverage area. One AP measured its performance by 26 measurement points and the other AP measured its performance by 20 measurement points. When AP has measured its performance then another AP position is switched off. Based on the measurement result, the received signal level value is the highest value is about -47 dBm at a distance of 3.2 m, while the lowest is about -79 dBm at a 9.21 m because it is on barrier 2 walls. While based on service coverage area, the area which is far away from the AP then the quality of service becomes bad because the transmitted signal is weakening caused by the distance and the loss of the wall.

AP1000, a nuclear central of advanced design

International Nuclear Information System (INIS)

Hernandez M, N.; Viais J, J.

2005-01-01

The AP1000 is a design of a nuclear reactor of pressurized water (PWR) of 1000 M We with characteristic of safety in a passive way; besides presenting simplifications in the systems of the plant, the construction, the maintenance and the safety, the AP1000 is a design that uses technology endorsed by those but of 30 years of operational experience of the PWR reactors. The program AP1000 of Westinghouse is focused to the implementation of the plant to provide improvements in the economy of the same one and it is a design that is derived directly of the AP600 designs. On September 13, 2004 the US-NRC (for their initials in United States- Nuclear Regulatory Commission) approved the final design of the AP1000, now Westinghouse and the US-NRC are working on the whole in a complete program for the certification. (Author)

Development of a framework based on an ecosystem services approach for deriving specific protection goals for environmental risk assessment of pesticides

International Nuclear Information System (INIS)

Nienstedt, Karin M.; Brock, Theo C.M.; Wensem, Joke van; Montforts, Mark; Hart, Andy; Aagaard, Alf; Alix, Anne; Boesten, Jos; Bopp, Stephanie K.; Brown, Colin; Capri, Ettore; Forbes, Valery; Köpp, Herbert; Liess, Matthias; Luttik, Robert; Maltby, Lorraine

2012-01-01

General protection goals for the environmental risk assessment (ERA) of plant protection products are stated in European legislation but specific protection goals (SPGs) are often not precisely defined. These are however crucial for designing appropriate risk assessment schemes. The process followed by the Panel on Plant Protection Products and their Residues (PPR) of the European Food Safety Authority (EFSA) as well as examples of resulting SPGs obtained so far for environmental risk assessment (ERA) of pesticides is presented. The ecosystem services approach was used as an overarching concept for the development of SPGs, which will likely facilitate communication with stakeholders in general and risk managers in particular. It is proposed to develop SPG options for 7 key drivers for ecosystem services (microbes, algae, non target plants (aquatic and terrestrial), aquatic invertebrates, terrestrial non target arthropods including honeybees, terrestrial non-arthropod invertebrates, and vertebrates), covering the ecosystem services that could potentially be affected by the use of pesticides. These SPGs need to be defined in 6 dimensions: biological entity, attribute, magnitude, temporal and geographical scale of the effect, and the degree of certainty that the specified level of effect will not be exceeded. In general, to ensure ecosystem services, taxa representative for the key drivers identified need to be protected at the population level. However, for some vertebrates and species that have a protection status in legislation, protection may be at the individual level. To protect the provisioning and supporting services provided by microbes it may be sufficient to protect them at the functional group level. To protect biodiversity impacts need to be assessed at least at the scale of the watershed/landscape. - Research highlights: ► How to define specific protection goals (SPGs) for environmental risk assessment? ► The process uses the ecosystem services (ES

ONLINE MINIMIZATION OF VERTICAL BEAM SIZES AT APS

Energy Technology Data Exchange (ETDEWEB)

Sun, Yipeng

2017-06-25

In this paper, online minimization of vertical beam sizes along the APS (Advanced Photon Source) storage ring is presented. A genetic algorithm (GA) was developed and employed for the online optimization in the APS storage ring. A total of 59 families of skew quadrupole magnets were employed as knobs to adjust the coupling and the vertical dispersion in the APS storage ring. Starting from initially zero current skew quadrupoles, small vertical beam sizes along the APS storage ring were achieved in a short optimization time of one hour. The optimization results from this method are briefly compared with the one from LOCO (Linear Optics from Closed Orbits) response matrix correction.

K-AP: Generating specified K clusters by efficient Affinity Propagation

KAUST Repository

Zhang, Xiangliang

2010-12-01

The Affinity Propagation (AP) clustering algorithm proposed by Frey and Dueck (2007) provides an understandable, nearly optimal summary of a data set. However, it suffers two major shortcomings: i) the number of clusters is vague with the user-defined parameter called self-confidence, and ii) the quadratic computational complexity. When aiming at a given number of clusters due to prior knowledge, AP has to be launched many times until an appropriate setting of self-confidence is found. The re-launched AP increases the computational cost by one order of magnitude. In this paper, we propose an algorithm, called K-AP, to exploit the immediate results of K clusters by introducing a constraint in the process of message passing. Through theoretical analysis and experimental validation, K-AP was shown to be able to directly generate K clusters as user defined, with a negligible increase of computational cost compared to AP. In the meanwhile, K-AP preserves the clustering quality as AP in terms of the distortion. K-AP is more effective than k-medoids w.r.t. the distortion minimization and higher clustering purity. © 2010 IEEE.

Protective effects of tropisetron on cerulein-induced acute pancreatitis in mice.

Science.gov (United States)

Rahimian, Reza; Zirak, Mohammad Reza; Seyedabadi, Mohammad; Keshavarz, Mojtaba; Rashidian, Amir; Kazmi, Sareh; Jafarian, Amir Hossein; Karimi, Gholamreza; Mousavizadeh, Kazem

2017-09-01

Acute pancreatitis (AP) causes morbidity and mortality. The aim of the present study was to investigate the protective effect of tropisetron against AP induced by cerulein. Cerulein (50μg/kg, 5 doses) was used to induce AP in mice. Six hours after final cerulein injection, animals were decapitated. Hepatic/pancreatic enzymes in the serum, pancreatic content of malondialdehyde (MDA), pro-inflammatory cytokines and myeloperoxidase (MPO) activity were measured. Tropisetron significantly attenuated pancreatic injury markers and decreased the amount of elevated serum amylase, lipase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), MPO activities and pro-inflammatory cytokines levels caused by AP in mice. Tropisetron didn't affect the pancreatic levels of MDA. Our results suggest that tropisetron could attenuate cerulein-induced AP by combating inflammatory signaling. Further clinical studies are needed to confirm its efficacy in patients with AP. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Advanced Photon Source (APS)

Data.gov (United States)

Federal Laboratory Consortium — The Advanced Photon Source (APS) at the U.S. Department of Energy's Argonne National Laboratoryprovides this nation's (in fact, this hemisphere's) brightest storage...

AP1000 - the new standard for nuclear power

International Nuclear Information System (INIS)

Lipman, Daniel S.

2006-01-01

Full text of publication follows: The AP1000 is the only Generation III+ reactor to receive Final Design Approval (FDA) from the Nuclear Regulatory Commission, and is expected to receive its Design Certification by the end of the year. Building on the proven features of current generation nuclear plants, the AP1000 combines experience with innovation into a design that surpasses current standards of safety and reliability. Use of passive safety features results in a simpler and more compact design that enhances safety, simplifies O and M requirements, and reduces capital and operating costs. At 1117 Mwe, the AP1000 is well suited for almost any grid system and will be fully competitive with combined-cycle gas and comparable fossil fuel plants. The AP1000 is ready to help launch a renaissance in new nuclear plant construction throughout the world. Maturity of Design: In excess of 1300 man-years and $400 million in development funding have been expended on the AP1000. It has undergone extensive, part scale testing at the system, sub-system and component level, in addition to a series of part scale integrated tests. The AP1000 is the most analyzed of the next generation reactors. Simplicity of Design/Economics: The AP1000 uses simplified and innovative passive safety systems to an unprecedented extent. Simplified passive safety systems provide reliable operation, reduced capital costs, and enhanced plant safety with large plant operating margins. The AP1000 features improved reliability through simplicity rather than addition of redundant safety trains. This simpler design is easier and less costly to operate and maintain than larger, more complex plants, while less equipment and smaller buildings translate into lower capital costs and shorter construction durations. After construction, economic benefit will be found in reduced operating and maintenance costs, largely due to reduced operating and maintenance staffing requirements. Construction aspects

Maintenance of the APS of an electron beam accelerator

International Nuclear Information System (INIS)

Lee, Byung Cheol; Choi, Hwa Lim; Yang, Ki Ho; Kim, Sung Chan

2008-12-01

APS is a part of power supply system which provides the high voltage, high current to the anode of electron beam in the irradiation facility in KAERI. This APS had been used in turn-key base for 10 years, and frequently the Russian scientists had visited to repair this machine. In Summer the humid air had been supplied to dissipate the heat of APS. There is a big and high frequency noise around the transformer in the mutation room. So we stopped the irradiation works and analyzed and repaired the APS. The main course of the problem is the deterioration of IGBT and thyristors which are components of phase controller. We replaced this by new one and APS is now operating well

Distributed photovoltaic system evaluation by Arizona Public Service Company

International Nuclear Information System (INIS)

Lambeth, R.; Lepley, T.

1993-01-01

Arizona Public Service Company (APS) has performed a study of the APS system to (1) determine whether APS has high-value distributed applications of photovoltaics (PV), (2) quantify the value of a distributed PV system, (3) compare the APS results with the earlier PG ampersand E results and (4) estimate whether there will be significant market for these applications at APS. The study confirmed that there is a value to distributing PV generation throughout the utility distribution system. The breakeven cost for a PV system in APS' best location is $3.44/watt, in 1996 dollars. Feeders which meet all the criteria and which will be eligible for full benefits are relatively rare. However, a PV system will usually have more value if it is distributed rather than installed at a central station site

Hanford Radiological Protection Support Services annual report for 1992

International Nuclear Information System (INIS)

Lyon, M.; Bihl, D.E.; Fix, J.J.; Piper, R.K.; Froelich, T.J.; Lynch, T.P.

1993-07-01

Various Hanford Site radiation protection services provided by the Pacific Northwest Laboratory for the US Department of Energy Richland Field Office and Hanford contractors are described in this annual report of calendar year 1992. These activities include internal dosimetry measurements and evaluations, in vivo measurements, external dosimetry measurements and evaluations, instrument calibration and evaluation, radiation source calibration, and radiological record keeping. For each of these activities, the routine program and any program changes or enhancements are described, as well as associated tasks, investigations, and studies. Program-related publications, presentations, and other staff professional activities are also described

Hanford radiological protection support services. Annual report for 1995

International Nuclear Information System (INIS)

Lyon, M.; Bihl, D.E.; Carbaugh, E.H.

1996-05-01

Various Hanford Site radiation protection services provided by the Pacific Northwest National Laboratory for the U.S. Department of Energy Richland Operations Office and Hanford contractors are described in this annual report for calendar year 1995. These activities include external dosimetry measurements and evaluations, internal dosimetry measurements and evaluations, in vivo measurements, radiological record keeping, radiation source calibration, and instrument calibration and evaluation. For each of these activities, the routine program and any program changes or enhancements are described, as well as associated tasks, investigations, and studies. Program-related publications, presentations, and other staff professional activities are also described

Hanford radiological protection support services annual report for 1997

Energy Technology Data Exchange (ETDEWEB)

Lyon, M.; Bihl, D.E.; Fix, J.J.; Johnson, M.L.; Lynch, T.P.; Piper, R.K.

1998-06-01

Various Hanford Site radiation protection services provided by the Pacific Northwest National Laboratory for the US Department of Energy Richland Operations Office and Hanford contractors are described in this annual report for calendar year 1997. These activities include external dosimetry measurements and evaluations, internal dosimetry measurements and evaluations, in vivo measurements, radiological exposure record keeping, radiation source calibration, and instrument calibration and evaluation. For each of these activities, the routine program and any program changes or enhancements are described as well as associated tasks, investigations, and studies. Program-related publications, presentations, and other staff professional activities are also described.

Hanford radiological protection support services annual report for 1990

International Nuclear Information System (INIS)

Lyon, M.; Bihl, D.E.; Fix, J.J.; Piper, R.K.; Freolich, T.J.; Leonowich, J.A.; Lynch, T.P.

1991-07-01

Various Hanford site-wide radiation protection services provided by the Pacific Northwest Laboratory for the US Department of Energy-Richland Operations Office and Hanford contractors are described in this annual report for calendar year 1990. These activities include internal dosimetry measurements and evaluations, in vivo measurements, external dosimetry measurements and evaluations, instrument calibration and evaluation, radiation source calibration, and radiological records keeping. For each of these activities, the routine program, program changes and enhancements, associated tasks, investigations and studies, and related publications, presentations, and other staff professional activities are discussed as applicable. 22 refs., 10 figs., 19 tabs

Hanford Radiological Protection Support Services annual report for 1993

International Nuclear Information System (INIS)

Lyon, M.; Bihl, D.E.; Fix, J.J.; Froelich, T.J.; Piper, R.K.; Olsen, P.C.

1994-07-01

Various Hanford Site radiation protection services provided by the Pacific Northwest Laboratory for the US Department of Energy Richland Operations Office and Hanford contractors are described in this annual report for calendar year 1993. These activities include internal dosimetry measurements and evaluations, in vivo measurements, external dosimetry measurements and evaluations, instrument calibration and evaluation, radiation source calibration, and radiological record keeping. For each of these activities, the routine program and any program changes or enhancements are described, as well as associated tasks, investigations, and studies. Program-related publications, presentations, and other staff professional activities are also described

Hanford radiological protection support services annual report for 1997

International Nuclear Information System (INIS)

Lyon, M.; Bihl, D.E.; Fix, J.J.; Johnson, M.L.; Lynch, T.P.; Piper, R.K.

1998-06-01

Various Hanford Site radiation protection services provided by the Pacific Northwest National Laboratory for the US Department of Energy Richland Operations Office and Hanford contractors are described in this annual report for calendar year 1997. These activities include external dosimetry measurements and evaluations, internal dosimetry measurements and evaluations, in vivo measurements, radiological exposure record keeping, radiation source calibration, and instrument calibration and evaluation. For each of these activities, the routine program and any program changes or enhancements are described as well as associated tasks, investigations, and studies. Program-related publications, presentations, and other staff professional activities are also described

Hanford radiological protection support services annual report for 1996

Energy Technology Data Exchange (ETDEWEB)

Lyon, M.; Bihl, D.E.; Fix, J.J.; Froelich, T.J.; Piper, R.K.; Schulze, S.A.

1997-06-01

Various Hanford Site radiation protection services provided by the Pacific Northwest National Laboratory for the US Department of Energy Richland Operations Office and Hanford contractors are described in this annual report for calendar year 1996. These activities include external dosimetry measurements and evaluations, internal dosimetry measurements and evaluations, in vivo measurements, radiological exposure record keeping, radiation source calibration, and instrument calibration and evaluation. For each of these activities, the routine program and any program changes or enhancements are described, as well as associated tasks, investigations, and studies. Program-related publications, presentations, and other staff professional activities are also described.

The APS control system network

International Nuclear Information System (INIS)

Sidorowicz, K.V.; McDowell, W.P.

1995-01-01

The APS accelerator control system is a distributed system consisting of operator interfaces, a network, and computer-controlled interfaces to hardware. This implementation of a control system has come to be called the open-quotes Standard Model.close quotes The operator interface is a UNDC-based workstation with an X-windows graphical user interface. The workstation may be located at any point on the facility network and maintain full functionality. The function of the network is to provide a generalized communication path between the host computers, operator workstations, input/output crates, and other hardware that comprise the control system. The crate or input/output controller (IOC) provides direct control and input/output interfaces for each accelerator subsystem. The network is an integral part of all modem control systems and network performance will determine many characteristics of a control system. This paper will describe the overall APS network and examine the APS control system network in detail. Metrics are provided on the performance of the system under various conditions

Service-learning and learning communities: two innovative school projects that are mutually enriched

Directory of Open Access Journals (Sweden)

Carmen ÁLVAREZ ÁLVAREZ

2015-12-01

Full Text Available This article reflects on the interrelationships that exist between two educational projects of today: service-learning (ApS and learning communities (CdA. The ApS is an educational methodology applied worldwide where a single project combines a learning based on experience with the implementation of a service to the community. CdA is a school transformation project to achieve that the information society does not exclude any person, constituting a reality in more than one hundred and ninety schools in Spain and Latin America. Between the two, it is possible to show differences, especially in what refers to its theoretical substrates, but in actual teaching practice in schools there is some harmony, particularly in the so closely that they cultivate both projects with the school community. Therefore, we conclude that service-learning and learning communities can occur as two innovative and relevant today projects which can be mutually enriching: because for both the approach school-community-environment and volunteering is essential.

A hot-spare injector for the APS linac

International Nuclear Information System (INIS)

Lewellen, J. W.

1999-01-01

Last year a second-generation SSRL-type thermionic cathode rf gun was installed in the Advanced Photon Source (APS) linac. This gun (referred to as ''gun2'') has been successfully commissioned and now serves as the main injector for the APS linac, essentially replacing the Koontz-type DC gun. To help ensure injector availability, particularly with the advent of top-up mode operation at the APS, a second thermionic-cathode rf gun will be installed in the APS linac to act as a hot-spare beam source. The hot-spare installation includes several unique design features, including a deep-orbit Panofsky-style alpha magnet. Details of the hot-spare beamline design and projected performance are presented, along with some plans for future performance upgrades

22 CFR 102.13 - Protective services with respect to deceased victims of accidents.

Science.gov (United States)

2010-04-01

... victims of accidents. 102.13 Section 102.13 Foreign Relations DEPARTMENT OF STATE ECONOMIC AND OTHER FUNCTIONS CIVIL AVIATION United States Aircraft Accidents Abroad § 102.13 Protective services with respect to deceased victims of accidents. (a) Interim disposition of remains. Generally, local authorities...

Characterization of liquid entrainment in the AP1000 automatic depressurization system from APEX tests

International Nuclear Information System (INIS)

Richard F Wright; Terry L Schulz; Jose N Reyes; John Groome

2005-01-01

Full text of publication follows: The AP1000 is a 1000 MWe advanced nuclear power plant that uses passive safety features to enhance plant safety and to provide significant and measurable improvements in plant simplification, reliability, investment protection and plant costs. The AP1000 relies heavily on the 600 MWe AP600 which received design certification in 1999. A critical part of the AP600 design certification process involved the testing of the passive safety systems. A one-fourth height, one-fourth pressure test facility, APEX-600, was constructed at the Oregon State University to study design basis events, and to provide a body of data to be used to validate the computer models used to analyze the AP600. This facility was extensively modified to reflect the design changes for AP1000 including higher power in the electrically heated rods representing the reactor core, and changes in the size of the pressurizer, core makeup tanks and automatic depressurization system. The APEX-1000 test facility was used to perform design basis accident simulations and separate effects tests to support the AP1000 design certification process. In the event of a LOCA, the AP1000 passive core cooling system provides sources of core makeup water along with an automatic depressurization system (ADS) consisting of several stages of valves which reduce the reactor coolant system pressure in a controlled manner. The final stage of this system, ADS-4, consists of four large valves that open off the hot legs, reducing the pressure to allow gravity injection from the in-containment refueling water storage tank (IRWST) and eventually the containment sump. The 67% increase in power from AP600 to AP1000 results in proportionally larger steam velocities exiting the core. Higher steam velocities could increases the potential for significant liquid entrainment out the ADS-4 lines, affecting the liquid inventory in the reactor. Tests were performed in APEX-1000 to characterize the two

Radiation protection safety in Uganda -- Experience and prospects of the National Radiation Protection Service

International Nuclear Information System (INIS)

Kisolo, A.

2001-01-01

The Uganda National Radiation Protection Service (NRPS) is a technical body under the Atomic Energy Control Board, established by Law - the Atomic Energy Decree of 1972, Decree No. 12, to oversee and enforce safety of radiation sources, practices and workers; and to protect the patients, members of the public and the environment from the dangers of ionizing radiation and radioactive wastes. The Ionizing Radiation Regulations (Standards) - Statutory Instruments Supplement No. 21 of 1996 -- back up the Law. The Law requires all users, importers and operators of radiation sources and radioactive materials to notify the NRPS for registration and licensing. The NRPS is responsible for licensing and for the regulatory enforcement of compliance to the requirements for the safety of radiation sources and practices. There are about 200 diagnostic X-ray units, two radiotherapy centres, one nuclear medicine unit, several neutron probes, about three level gauges and two non-destructive testing sources and a number of small sealed sources in teaching and research institutions. About 50% of these sources have been entered in our inventory using the RAIS software provided by the IAEA. There are about 500 radiation workers and 250 underground miners. The NRPS covers about 50% of the radiation workers. It is planned that by June 2001, all occupational workers will be monitored, bringing coverage to 100%. The Government of Uganda is making the necessary legal, administrative and technical arrangements aimed at establishing the National Radiation Protection Commission as an autonomous regulatory authority. The Atomic Energy Decree of 1972 and Regulations of 1996 are being revised to provide for the National Radiation Protection Commission and to make it comply with the requirements of the International Basic Safety Standards Safety Series No. 115. (author)

An Asset Protection Scheme for Banks Exposed to Troubled Loan Portfolios

DEFF Research Database (Denmark)

Grosen, Anders; Jessen, Pernille; Kokholm, Thomas

2014-01-01

We examine a specific portfolio credit derivative, an Asset Protection Scheme (APS), and its applicability as a discretionary regulatory tool to reduce asymmetric information and help restore the capital base of troubled banks. The APS can be a fair-valued contract with an appropriate structure...... of incentives. We apply two alternative multivariate structural default risk models: the classical Gaussian Merton model and a model based on Normal Inverse Gaussian processes. Using a data set on annual farm level data from 1996 to 2009, we use the Danish agricultural sector as a case study and price an APS...... on an agricultural loan portfolio. We compute the economic capital for this loan portfolio with and without an APS. Moreover, we illustrate how model risk in the form of parameter uncertainty is reduced when an APS is attached to the loan portfolio....

Studies of microparticles in patients with the antiphospholipid syndrome (APS).

Science.gov (United States)

Vikerfors, A; Mobarrez, F; Bremme, K; Holmström, M; Ågren, A; Eelde, A; Bruzelius, M; Antovic, A; Wallén, H; Svenungsson, E

2012-06-01

To study circulating platelet, monocyte and endothelial microparticles (PMPs, MMPs and EMPs) in patients with antiphospholipid syndrome (APS) in comparison with healthy controls. Fifty-two patients with APS and 52 healthy controls were investigated. MPs were measured on a flow cytometer (Beckman Gallios) and defined as particles sized APS patients versus controls (p APS patients. We observed a high number of EMPs expressing TF in APS patients. The numbers of MMPs and total EMPs were also higher as compared with healthy controls but in contrast to previous reports, the number of PMPs did not differ between groups.

Preliminary analyses of AP600 using RELAP5

International Nuclear Information System (INIS)

Modro, S.M.; Beelman, R.J.; Fisher, J.E.

1991-01-01

This paper presents results of preliminary analyses of the proposed Westinghouse Electric Corporation AP600 design. AP600 is a two loop, 600 MW (e) pressurized water reactor (PWR) arranged in a two hot leg, four cold leg nuclear steam supply system (NSSS) configuration. In contrast to the present generation of PWRs it is equipped with passive emergency core coolant (ECC) systems. Also, the containment and the safety systems of the AP600 interact with the reactor coolant system and each other in a more integral fashion than present day PWRs. The containment in this design is the ultimate heat sink for removal of decay heat to the environment. Idaho National Engineering Laboratory (INEL) has studied applicability of the RELAP5 code to AP600 safety analysis and has developed a model of the AP600 for the Nuclear Regulatory Commission. The model incorporates integral modeling of the containment, NSSS and passive safety systems. Best available preliminary design data were used. Nodalization sensitivity studies were conducted to gain experience in modeling of systems and conditions which are beyond the applicability of previously established RELAP5 modeling guidelines or experience. Exploratory analyses were then undertaken to investigate AP600 system response during postulated accident conditions. Four small break LOCA calculations and two large break LOCA calculations were conducted

FRANX. Application for analysis and quantification of the APS fire; FRANK. Aplicacion para el analisis y cuantificacion de los APS de incendios

Energy Technology Data Exchange (ETDEWEB)

Snchez, A.; Osorio, F.; Ontoso, N.

2014-07-01

The FRANX application has been developed by EPRI within the Risk and Reliability User Group in order to facilitate the process of quantification and updating APS Fire (also covers floods and earthquakes). By applying fire scenarios are quantified in the central integrating the tasks performed during the APS fire. This paper describes the main features of the program to allow quantification of an APS Fire. (Author)

Assistant practitioners (APs) perceptions of their developing role and practice in radiography: Results from a national survey

International Nuclear Information System (INIS)

Stewart-Lord, Adele; McLaren, Susan M.; Ballinger, Claire

2011-01-01

Introduction: In 2000, the NHS Plan set out the government's plans for investment and reform across the NHS. Through the introduction of a new workforce at assistant practitioner (AP) level the Department of Health intended to implement new ways in which to deliver a more efficient service. At the time, little published information existed on the integration of these assistants into the contemporary radiography workforce. Publications were limited to experiences gained by various individual departments ranging in their perception of the role and education of APs. Further research was suggested to track the continuing implementation of the 4-tier structure, establish the precise nature and scope of the roles across Trusts and determine their impact on workload and patient care. Aim: To establish the number and employment locality of APs in radiography professions in England, and to explore their scope of applied practice. Method and materials: The study was conducted over three phases and employed a mixed methods design to address the aims and objectives. Phase I was a scoping exercise performed prior to data collection in which n = 226 radiography sites were identified for contact across England. Phase II utilized a questionnaire as data collection tool to investigate the role of APs in radiography and explore how their roles were integrated into the radiography workforce in England. Results from phase III of the study which utilized semi-structured qualitative interviews are not included in this paper. Conclusion and discussion: Key findings depict the nature and variety of roles and responsibilities undertaken by APs in radiography. This study was the first of its kind to identify the integration of APs in radiography across a sizable geographical region. There were mixed responses to the question asking APs if they were required to perform duties outside their scope of practice. Questionnaire data revealed that a high numbers of APs were working in areas under

Environmental Protection Agency Semiannual Regulatory Agenda

Science.gov (United States)

2010-12-20

... of the economy, productivity, competition, jobs, the environment, public health or safety, or State... Steve Fruh, Environmental Protection Agency, Air and Radiation, 1200 Pennsylvania Ave, NW, Washington, DC 20460 Phone: 919 541-2837 Fax: 919 541-4991 Email: fruh.steve@epamail.epa.gov RIN: 2060-AP69...

Training and development of the Assistant Practitioners (APs) in radiography

International Nuclear Information System (INIS)

Stewart-Lord, Adéle

2014-01-01

A mixed methods study conducted over three phases (Phase I – scoping exercise, Phase II – questionnaire and Phase III – semi-structured interviews) aimed to explore the role and integration of the assistant practitioner (AP) practitioner in radiography from the AP perspective. Findings of the overall study are presented across a range of articles where this publication only presents the findings in relation to the training and education of APs from all three phases. Results showed the educational routes undertaken by APs in radiography during training. Training whilst working in the clinical department has highlighted a number of key issues relating to educational pathways and delivery methods. Findings showed that APs felt that more could be done to prepare the individual for clinical practice thereby increasing their confidence and facilitating role development. Results also identified a number of challenges in the training and education of APs in radiography. Clear routes of progression and career pathways are not available to APs in radiography. In conclusion the findings suggest the need for a review of existing educational programmes and future standardisation. The need exists to clarify the justifiable methods of training and differentiate between recognised educational qualifications to enable informed career development decisions by APs and their employers

[Diverse histological lesions in a patient with antiphospholipid syndrome (APS)].

Science.gov (United States)

Salvatore, Ermanno; Luciani, Remo; Di Palma, Annamaria; Aversano, Arturo; Stellato, Davide; Liuzzi, Marco; Iele, Emilio; Martignetti, Vinicio; Spagnuolo, Enrico; Morrone, Luigi

2011-01-01

Antiphospholipid syndrome (APS) is a rare autoimmune disorder. It can be secondary to systemic lupus erythematosus (SLE) or occur in the absence of autoimmune disease. The hallmark of this so-called primary APS is the presence of circulating antiphospholipid antibodies. Renal involvement in primary APS is caused by thrombosis within the renal vasculature. Recently, nonthrombotic glomerulonephritic renal lesions have been described in primary APS as a new histological entity. We here report a patient with primary APS in whom both lesion types were present. A 58-year-old Caucasian man with no significant past medical history presented to our nephrology unit with diffuse edema. Urinalysis showed proteinuria exceeding 400 mg/dL. The autoantibody panel (p-ANCA, c- ANCA, anti-nucleus, anti-DS-DNA) was negative except for anticardiolipin antibodies, which tested positive in two different samples. The diagnostic workup included a kidney biopsy that revealed thrombotic lesions compatible with primary APS and a typical pattern of focal segmental glomerulosclerosis. The kidney is a major target in APS but the exact mechanism underlying the pathogenesis of APS nephropathy has been poorly recognized. The use of kidney biopsy is a fundamental diagnostic tool in this setting, with possible implications also from a prognostic and therapeutic viewpoint.

Recessive loss-of-function mutations in AP4S1 cause mild fever-sensitive seizures, developmental delay and spastic paraplegia through loss of AP-4 complex assembly

Science.gov (United States)

Hardies, Katia; May, Patrick; Djémié, Tania; Tarta-Arsene, Oana; Deconinck, Tine; Craiu, Dana; Helbig, Ingo; Suls, Arvid; Balling, Rudy; Weckhuysen, Sarah; De Jonghe, Peter; Hirst, Jennifer; Afawi, Zaid; Barisic, Nina; Baulac, Stéphanie; Caglayan, Hande; Depienne, Christel; De Kovel, Carolien G.F.; Dimova, Petia; Guerrero-López, Rosa; Guerrini, Renzo; Hjalgrim, Helle; Hoffman-Zacharska, Dorota; Jahn, Johanna; Klein, Karl Martin; Koeleman, Bobby P.C.; Leguern, Eric; Lehesjoki, Anna-Elina; Lemke, Johannes; Lerche, Holger; Marini, Carla; Muhle, Hiltrud; Rosenow, Felix; Serratosa, Jose M.; Møller, Rikke S.; Stephani, Ulrich; Striano, Pasquale; Talvik, Tiina; Von Spiczak, Sarah; Weber, Yvonne; Zara, Federico

2015-01-01

We report two siblings with infantile onset seizures, severe developmental delay and spastic paraplegia, in whom whole-genome sequencing revealed compound heterozygous mutations in the AP4S1 gene, encoding the σ subunit of the adaptor protein complex 4 (AP-4). The effect of the predicted loss-of-function variants (p.Gln46Profs*9 and p.Arg97*) was further investigated in a patient's fibroblast cell line. We show that the premature stop mutations in AP4S1 result in a reduction of all AP-4 subunits and loss of AP-4 complex assembly. Recruitment of the AP-4 accessory protein tepsin, to the membrane was also abolished. In retrospect, the clinical phenotype in the family is consistent with previous reports of the AP-4 deficiency syndrome. Our study reports the second family with mutations in AP4S1 and describes the first two patients with loss of AP4S1 and seizures. We further discuss seizure phenotypes in reported patients, highlighting that seizures are part of the clinical manifestation of the AP-4 deficiency syndrome. We also hypothesize that endosomal trafficking is a common theme between heritable spastic paraplegia and some inherited epilepsies. PMID:25552650

AP600 - an ALWR conceptual design

International Nuclear Information System (INIS)

Bruce, R.A.; Vijuk, R.P.

1988-01-01

The Electric Power Research Institute is spearheading an effort to develop utility requirements for the Advanced Light Water Reactor (ALWR) plants which will become the next generation nuclear power plants for the U.S. This EPRI ALWR Program involves utilities, the U.S. Department of Energy, the U.S. Nuclear Regulatory Commission, and various industry suppliers. The ALWR Program is aimed at ALWR plants which incorporate step improvements in safety, reliability, operability and power generation costs. As part of the ALWR efforts, a Westinghouse team is conducting conceptual design development of a PWR plant design called the AP600, reflecting advanced passive safety features and the chosen 600 MWe plant output. The AP600 conceptual design provides significant improvements while employing proven component technology. This paper describes the basic reactor and primary coolant system features, the passive safety system features, and plant arrangement/construction features of AP600

Hanford Radiological Protection Support Services Annual Report for 1999

Energy Technology Data Exchange (ETDEWEB)

TP Lynch; DE Bihl; ML Johnson; MA MacLellan; RK Piper

2000-05-19

During calendar year (CY) 1999, the Pacific Northwest National Laboratory (PNNL) performed its customary radiological protection support services in support of the U.S. Department of Energy (DOE) Richland Operations Office (RL) and the Hanford contractors. These services included: (1) external dosimetry, (2) internal dosimetry, (3) in vivo measurements, (4) radiological records, (5) instrument calibration and evaluation, and (6) calibration of radiation sources traceable to the National Institute of Standards and Technology (NIST). The services were provided under a number of programs as summarized here. Along with providing site-wide nuclear accident and environmental dosimetry capabilities, the Hanford External Dosimetry Program (HEDP) supports Hanford radiation protection programs by providing external radiation monitoring capabilities for all Hanford workers and visitors to help ensure their health and safety. Processing volumes decreased in CY 1999 relative to prior years for all types of dosimeters, with an overall decrease of 19%. During 1999, the HEDP passed the National Voluntary Laboratory Accreditation Program (NVLAP) performance testing criteria in 15 different categories. HEDP computers and processors were tested and upgraded to become Year 2000 (Y2K) compliant. Several changes and improvements were made to enhance the interpretation of dosimeter results. The Hanford Internal Dosimetry Program (HIDP) provides for the assessment and documentation of occupational dose from intakes of radionuclides at the Hanford Site. Performance problems carried over from CY 1998 continued to plague the in vitro bioassay contractor. A new contract was awarded for the in vitro bioassay program. A new computer system was put into routine operation by the in vivo bioassay program. Several changes to HIDP protocols were made that were related to bioassay grace periods, using field data to characterize the amount of alpha activity present and using a new default particle

Hanford Radiological Protection Support Services Annual Report for 1999

International Nuclear Information System (INIS)

TP Lynch; DE Bihl; ML Johnson; MA MacLellan; RK Piper

2000-01-01

During calendar year (CY) 1999, the Pacific Northwest National Laboratory (PNNL) performed its customary radiological protection support services in support of the U.S. Department of Energy (DOE) Richland Operations Office (RL) and the Hanford contractors. These services included: (1) external dosimetry, (2) internal dosimetry, (3) in vivo measurements, (4) radiological records, (5) instrument calibration and evaluation, and (6) calibration of radiation sources traceable to the National Institute of Standards and Technology (NIST). The services were provided under a number of programs as summarized here. Along with providing site-wide nuclear accident and environmental dosimetry capabilities, the Hanford External Dosimetry Program (HEDP) supports Hanford radiation protection programs by providing external radiation monitoring capabilities for all Hanford workers and visitors to help ensure their health and safety. Processing volumes decreased in CY 1999 relative to prior years for all types of dosimeters, with an overall decrease of 19%. During 1999, the HEDP passed the National Voluntary Laboratory Accreditation Program (NVLAP) performance testing criteria in 15 different categories. HEDP computers and processors were tested and upgraded to become Year 2000 (Y2K) compliant. Several changes and improvements were made to enhance the interpretation of dosimeter results. The Hanford Internal Dosimetry Program (HIDP) provides for the assessment and documentation of occupational dose from intakes of radionuclides at the Hanford Site. Performance problems carried over from CY 1998 continued to plague the in vitro bioassay contractor. A new contract was awarded for the in vitro bioassay program. A new computer system was put into routine operation by the in vivo bioassay program. Several changes to HIDP protocols were made that were related to bioassay grace periods, using field data to characterize the amount of alpha activity present and using a new default particle

AP1000R licensing and deployment in the United States

International Nuclear Information System (INIS)

Jordan, R. P.; Russ, P. A.; Filiak, P. P.; Castiglione, L. L.

2012-01-01

In recent years, both domestic and foreign utilities have turned to the standardized Westinghouse AP1000 plant design in satisfying their near - and long-term - sustainable energy needs. As direct support to these actions, licensing the AP1000 design has played a significant role by providing one of the fundamental bases in clearing regulatory hurdles leading to the start of new plant construction. Within the U.S. alone, Westinghouse AP1000 licensing activities have reached unprecedented milestones with the approvals of both AP1000 Design Certification and Southern Company's combined construction permit and operating license (COL) application directly supporting the construction of two new nuclear plants in Georgia. Further COL application approvals are immediately pending for an additional two AP1000 plants in South Carolina. And, across the U.S. nuclear industry spectrum, there are 10 other COL applications under regulatory review representing some 16 new plants at 10 sites. In total, these actions represent the first wave of new plant licensing under the regulatory approval process since 1978. Fundamental to the Nuclear Regulatory Commission's AP1000 Design Certification is the formal recognition of the AP1000 passive safety design through regulatory acceptance rulemaking. Through recognition and deployment of the AP1000 Design Certification, the utility licensee / operator of this reactor design are now offered an opportunity to use a simplified 'one-step' combined license process, thereby managing substantial back-end construction schedule risk from regulatory and intervention delays. Application of this regulatory philosophy represents both acceptance and encouragement of standardized reactor designs like the AP1000. With the recent AP1000 Design Certification and utility COL acceptances, the fundamental licensing processes of this philosophy have successfully proven the attainment of significant milestones with the next stage licensing actions directed

The French Central Service for Protection against ionizing radiations (SCPRI), its activity

International Nuclear Information System (INIS)

Pellerin, P.; Moroni, J.P.

1979-01-01

The French Central Service for Protection against Ionizing Radiations (SCPRI), a service of Public Health and Labour departments, is entrusted by the French radioprotection regulations, of the control on a national scale, of all activities involving the use of ionizing radiations. It uses on this purpose, 4000 square meters of laboratories equiped with important radioanalyze and counting facilities (among them, a 100 low background β counters room). The SCPRI has also been nominated by WHO, as International Reference Center for radioactivy measurements in the environment. These duties have led the SCPRI to develop a drastic quality control of the techniques of preparation and verification of standard sources and reference samples [fr

Classification of Ap-stars HR 830 and ZI CVn

International Nuclear Information System (INIS)

Zverko, J.

1984-01-01

Two ambiguously classified Ap-stars, HR 830 and 21 CVn, are studied. The observational data are compared with the data for normal stars αDel and αLyr. Star HR 830 is classified as Ap of type Si based on the enhanced absorption in the Si lines and photometric variability in UBV. 21 CVn is classified as Ap Si based on weaker absorption of helium, the variability of helium lines, photometric periodic variability and the properties of the UV spectrum. It is concluded that the photometric periodic variability is a good indicator of Ap-properties of rapidly rotating A and late B stars. (author)

Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons.

Directory of Open Access Journals (Sweden)

Young-Mi Lim

Full Text Available Sensory organs are constantly exposed to physical and chemical stresses that collectively threaten the survival of sensory neurons. Failure to protect stressed neurons leads to age-related loss of neurons and sensory dysfunction in organs in which the supply of new sensory neurons is limited, such as the human auditory system. Transducin β-like protein 1 (TBL1 is a candidate gene for ocular albinism with late-onset sensorineural deafness, a form of X-linked age-related hearing loss. TBL1 encodes an evolutionarily conserved F-box-like and WD40 repeats-containing subunit of the nuclear receptor co-repressor/silencing mediator for retinoid and thyroid hormone receptor and other transcriptional co-repressor complexes. Here we report that a Drosophila homologue of TBL1, Ebi, is required for maintenance of photoreceptor neurons. Loss of ebi function caused late-onset neuronal apoptosis in the retina and increased sensitivity to oxidative stress. Ebi formed a complex with activator protein 1 (AP-1 and was required for repression of Drosophila pro-apoptotic and anti-apoptotic genes expression. These results suggest that Ebi/AP-1 suppresses basal transcription levels of apoptotic genes and thereby protects sensory neurons from degeneration.

AIRE variations in Addison's disease and autoimmune polyendocrine syndromes (APS)

DEFF Research Database (Denmark)

Bøe Wolff, A S; Oftedal, B; Johansson, S

2008-01-01

Autoimmune Addison's disease (AAD) is often associated with other components in autoimmune polyendocrine syndromes (APS). Whereas APS I is caused by mutations in the AIRE gene, the susceptibility genes for AAD and APS II are unclear. In the present study, we investigated whether polymorphisms...

Economic value of ecosystem services in Protected Landscape Areas n the Czech Republic

Czech Academy of Sciences Publication Activity Database

Daněk, Jan; Vačkář, David; Lorencová, Eliška

2017-01-01

Roč. 10, 1-2 (2017), s. 99-112 ISSN 1803-2451 R&D Projects: GA MŠk(CZ) LO1415 Institutional support: RVO:67179843 Keywords : ecosystem services * economic valuation * Protected Landscape Areas * forest ecosystems Subject RIV: EH - Ecology, Behaviour OBOR OECD: Environmental sciences (social aspects to be 5.7)

Final report for tank 241-AP-108, grab samples 8AP-96-1, 8AP-96-2 and 8AP-96-FB

International Nuclear Information System (INIS)

Esch, R.A.

1996-01-01

This document is the final report deliverable for the tank 241-AP-108 grab samples. The samples were subsampled and analyzed in accordance with the TSAP. Included in this report are the results for the Waste Compatibility analyses, with the exception of DSC and thermogravimetric analysis (TGA) results which were presented in the 45 Day report (Part 2 of this document). The raw data for all analyses, with the exception of DSC and TGA, are also included in this report

AP1000 plant construction in China: Ansaldo Nucleare contribution

International Nuclear Information System (INIS)

Frogheri, Monica; Saiu, Gianfranco

2009-01-01

On 24th of July 2007 Westinghouse Electric Co. signed landmark contracts with China's State Nuclear Power Technology Corporation (SNPTC), to provide four AP1000 nuclear power plants in China. The AP1000 is a two-loop 1117 MWe Pressurized Water Reactor (PWR). It is based on proven technology, but with an emphasis on safety features that rely on natural driving forces, such as pressurized gas, gravity flow, natural circulation flow and convection. Ansaldo Nucleare has provided a significant support to the passive plant technology development and, starting from 2000, is cooperating with Westinghouse to development of the AP1000 Plant. In the frame of the AP1000 Chinese agreement, Ansaldo Nucleare, in Joint Venture with Mangiarotti Nuclear, has signed a contract with Westinghouse for the design and the supply of innovative components to be installed in the first AP1000 unit to be constructed at the Sanmen site. The contract includes: the design of the steel containment vessel, preparation of construction and fabrication, specifications, design and supply of SCV mechanical penetrations, air locks and equipment hatches. Moreover, Ansaldo Nucleare is in charge of the final design of the AP1000 PRHR-HX and together with Mangiarotti Nuclear will supply the component for the Sanmen Unit 1 NPP. The paper presents an overview of the design and manufacturing activities performed by Ansaldo Nucleare and its partners for the AP1000 plant in China. (authors)

45-Day safety screening report for grab samples from Tank 241-AP-107

International Nuclear Information System (INIS)

Miller, G.L.

1995-01-01

Three samples; 107-AP-1C, 107-AP-2c and 107-AP-3C; were received at 222-S Laboratory for analysis of DSC, TGA and visual appearance. Four additional samples; 107-AP-1D, 107-AP-2D, 107-AP-3D and 107-AP-6; were received for visual appearance only. No results exceeded the safety screen notification criteria. This report compiles the analytical results. Tank 241-AP-107 is a double-shell tank which is not on any of the four Watch Lists

RAD51AP2, a novel vertebrate- and meiotic-specific protein, sharesa conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51

Energy Technology Data Exchange (ETDEWEB)

Kovalenko, Oleg V.; Wiese, Claudia; Schild, David

2006-07-25

Many interacting proteins regulate and/or assist the activities of RAD51, a recombinase which plays a critical role in both DNA repair and meiotic recombination. Yeast two-hybrid screening of a human testis cDNA library revealed a new protein, RAD51AP2 (RAD51 Associated Protein 2), that interacts strongly with RAD51. A full-length cDNA clone predicts a novel vertebrate specific protein of 1159 residues, and the RAD51AP2 transcript was observed only in meiotic tissue (i.e. adult testis and fetal ovary), suggesting a meiotic-specific function for RAD51AP2. In HEK293 cells the interaction of RAD51 with an ectopically-expressed recombinant large fragment of RAD51AP2 requires the C-terminal 57 residues of RAD51AP2. This RAD51-binding region shows 81% homology to the C-terminus of RAD51AP1/PIR51, an otherwise totally unrelated RAD51-binding partner that is ubiquitously expressed. Analyses using truncations and point mutations in both RAD51AP1 and RAD51AP2 demonstrate that these proteins use the same structural motif for RAD51 binding. RAD54 shares some homology with this RAD51-binding motif, but this homologous region plays only an accessory role to the adjacent main RAD51-interacting region, which has been narrowed here to 40 amino acids. A novel protein, RAD51AP2, has been discovered that interacts with RAD51 through a C-terminal motif also present in RAD51AP1.

Radiation protection service for a nucleonic control system of continuous casting plant after events of accident

International Nuclear Information System (INIS)

Chakrabarti, Santanu; Massand, O.P.

1998-01-01

Extensive use of nucleonic control systems like level controllers was observed during radiation protection surveys in industries such as refineries, steel plants etc., located in the eastern region of India. There were two accidents at continuous casting plant in 1995 which affected the nucleonic control system installed in 1992. The authorities contacted Bhabha Atomic Research Centre (BARC) for radiation protection surveys for the involved nucleonic gauges. The present paper describes the radiation protection services rendered by BARC during such accidents. (author)

Quantifying causal mechanisms to determine how protected areas affect poverty through changes in ecosystem services and infrastructure

Science.gov (United States)

Ferraro, Paul J.; Hanauer, Merlin M.

2014-01-01

To develop effective environmental policies, we must understand the mechanisms through which the policies affect social and environmental outcomes. Unfortunately, empirical evidence about these mechanisms is limited, and little guidance for quantifying them exists. We develop an approach to quantifying the mechanisms through which protected areas affect poverty. We focus on three mechanisms: changes in tourism and recreational services; changes in infrastructure in the form of road networks, health clinics, and schools; and changes in regulating and provisioning ecosystem services and foregone production activities that arise from land-use restrictions. The contributions of ecotourism and other ecosystem services to poverty alleviation in the context of a real environmental program have not yet been empirically estimated. Nearly two-thirds of the poverty reduction associated with the establishment of Costa Rican protected areas is causally attributable to opportunities afforded by tourism. Although protected areas reduced deforestation and increased regrowth, these land cover changes neither reduced nor exacerbated poverty, on average. Protected areas did not, on average, affect our measures of infrastructure and thus did not contribute to poverty reduction through this mechanism. We attribute the remaining poverty reduction to unobserved dimensions of our mechanisms or to other mechanisms. Our study empirically estimates previously unidentified contributions of ecotourism and other ecosystem services to poverty alleviation in the context of a real environmental program. We demonstrate that, with existing data and appropriate empirical methods, conservation scientists and policymakers can begin to elucidate the mechanisms through which ecosystem conservation programs affect human welfare. PMID:24567397

The Impact of Child, Family, and Child Protective Services Factors on Reports of Child Sexual Abuse Recurrence

Science.gov (United States)

Sinanan, Allison N.

2011-01-01

This study identified selected child factors (e.g., age, gender, race/ethnicity, disabilities, prior victimization, and relationship to perpetrator of abuse), family risk factors (e.g., substance abuse, domestic violence, inadequate housing, and financial problems), and services provided by child protective services that likely increased reports…

Radiological Protection Service of CN Asco; Servicio de ProteccionRadiologica de C. N. Asco

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-07-01

Briefly explains the structure of Radiation Protection Service (SPR) of CN Asco to address these performances, as well as a short description of the main activities that have been reinforced or have been incorporated into the routine activities of the SPR. (Author)

Packaging design criteria, transfer and disposal of 102-AP mixer pump

International Nuclear Information System (INIS)

Carlstrom, R.F.

1994-01-01

A mixer pump installed in storage tank 241-AP-102 (102-AP) has failed. This pump is referred to as the 102-AP mixer pump (APMP). The APMP will be removed from 102-AP 1 and a new pump will be installed. The main purpose of the Packaging Design Criteria (PDC) is to establish criteria necessary to design and fabricate a shipping container for the transfer and storage of the APMP from 102-AP. The PDC will be used as a guide to develop a Safety Evaluation for Packaging (SEP)

GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.

Directory of Open Access Journals (Sweden)

Ying Zhou

Full Text Available BACKGROUND: Our previous studies showed a down-regulation of GRIM-19 in primary human cervical cancers, and restoration of GRIM-19 induced tumor regression. The induction of tumor suppressor protein p53 ubiquitination and degradation by E6 oncoportein of high risk-HPV through forming a stable complex with E6AP is considered as a critical mechanism for cervical tumor development. The aims of this study were to determine the potential role of GRIM-19 in rescuing p53 protein and inducing cervical cancer cell apoptosis. METHODOLOGY/PRINCIPAL FINDINGS: The protein levels of GRIM-19 and p53 were detected in normal cervical tissues from 45 patients who underwent hysterectomy for reasons other than neoplasias of either the cervix or endometrium, and cervical cancer tissues from 60 patients with non-metastatic squamous epithelial carcinomas. Coimmunoprecipitation and GST pull-down assay were performed to examine the interaction of GRIM-19 with 18E6 and E6AP in vivo and in vitro respectively. The competition of 18E6 with E6AP in binding GRIM-19 by performing competition pull-down assays was designed to examine the disruption of E6/E6AP complex by GRIM-19. The augment of E6AP ubiquitination by GRIM-19 was detected in vivo and in vitro ubiquitination assay. The effects of GRIM-19-dependent p53 accumulation on cell proliferation, cell cycle, apoptosis were explored by MTT, flow cytometry and transmission electron microscopy respectively. The tumor suppression was detected by xenograft mouse model. CONCLUSION/SIGNIFICANCE: The levels of GRIM-19 and p53 were concurrently down regulated in cervical cancers. The restoration of GRIM-19 can induce ubiquitination and degradation of E6AP, and disrupt the E6/E6AP complex through the interaction of N-terminus of GRIM-19 with both E6 and E6AP, which protected p53 from degradation and promoted cell apoptosis. Tumor xenograft studies also revealed the suppression of p53 degradation in presence of GRIM-19. These data

Enhancing AP1000 reactor accident management capabilities for long term accidents

International Nuclear Information System (INIS)

Jiang Pingting; Liu Mengying; Duan Chengjie; Liao Yehong

2015-01-01

Passive safety actions are considered as main measures under severe accident in AP1000 power plant. However, risk is still existed. According to PSA, several probable scenarios for AP1000 nuclear power plant are analyzed in this paper with MAAP the severe accident analysis code. According to the analysis results, several deficiencies of AP1000 severe accident management are found. The long term cooling and containment depressurization capability for AP1000 power plant appear to be most important factors under such accidents. Then, several temporary strategies for AP1000 power plant are suggested, including PCCWST temporary water supply strategy after 72h, temporary injection strategy for IRWST, hydrogen relief action in fuel building, which would improve the safety of AP1000 power plant. At last, assessments of effectiveness for these strategies are performed, and the results are compared with analysis without these strategies. The comparisons showed that correct actions of these strategies would effectively prevent the accident process of AP1000 power plant. (author)

AP@home: The Artificial Pancreas Is Now at Home.

Science.gov (United States)

Heinemann, Lutz; Benesch, Carsten; DeVries, J Hans

2016-07-01

In the past years the development of an artificial pancreas (AP) has made great progress and many activities are ongoing in this area of research. The major step forward made in the last years was moving the evaluation of AP systems from highly controlled experimental conditions to daily life conditions at the home of patients with diabetes; this was also the aim of the European Union-funded AP@home project. Over a time period of 5 years a series of clinical studies were performed that culminated in 2 "final studies" during which an AP system was used by patients in their home environment for 2 or 3 months without supervision by a physician, living their normal lives. Two different versions of the AP system developed within this project were evaluated. A significant improvement in glycated hemoglobin was observed during closed-loop conditions despite the fact that during the control period the patients used the best currently available therapeutic option. In addition, a "single-port AP system" was developed within the project that combines continuous glucose monitoring and insulin infusion at a single tissue site. By using such a combined device the patients not only have to carry one less device around, the number of access points through the skin is also reduced from 2 to 1. In summary, close cooperation of 12 European partners, both academic centers and industry, enabled the development and evaluation of AP systems under daily life conditions. The next step is to develop these into products in cooperation with commercial partners. © 2016 Diabetes Technology Society.

Essence and characteristics of the Westinghouse technology AP1000

International Nuclear Information System (INIS)

Llovet, Ricardo

2014-01-01

The AP1000 nuclear power plant can place the reactor in a Safe Shutdown Condition within the first 72 hours of a Station Blackout, without the use of AC power or operator action •With some operator action after 3 days, the AP1000 nuclear power plant continues to maintain reactor core cooling and Spent Fuel Pool cooling indefinitely •The AP1000 nuclear power plant has superior coping capabilities as well as significantly reduced risk for core damage

Teaching Materials and Strategies for the AP Music Theory Exam

Science.gov (United States)

Lively, Michael T.

2017-01-01

Each year, many students take the Advanced Placement (AP) Music Theory Exam, and the majority of these students enroll in specialized AP music theory classes as part of the preparation process. For the teachers of these AP music theory classes, a number of challenges are presented by the difficulty and complexity of the exam subject material as…

[Innovative Services: The Use of Parent Aides in Child Protective Services]. Module 2. Program Models--Which One is Right for You?

Science.gov (United States)

Anderson, Stephen C.; And Others

Module 2 of a seven module package for child protective service workers explores various types of parent aide programs for abused and neglected children and their families. Four training activities address models of parent aide programs, organization analysis, and selection of the appropriate program model. Included are directions for using the…

NECAPs are negative regulators of the AP2 clathrin adaptor complex.

Science.gov (United States)

Beacham, Gwendolyn M; Partlow, Edward A; Lange, Jeffrey J; Hollopeter, Gunther

2018-01-18

Eukaryotic cells internalize transmembrane receptors via clathrin-mediated endocytosis, but it remains unclear how the machinery underpinning this process is regulated. We recently discovered that membrane-associated muniscin proteins such as FCHo and SGIP initiate endocytosis by converting the AP2 clathrin adaptor complex to an open, active conformation that is then phosphorylated (Hollopeter et al., 2014). Here we report that loss of ncap-1 , the sole C. elegans gene encoding an adaptiN Ear-binding Coat-Associated Protein (NECAP), bypasses the requirement for FCHO-1. Biochemical analyses reveal AP2 accumulates in an open, phosphorylated state in ncap-1 mutant worms, suggesting NECAPs promote the closed, inactive conformation of AP2. Consistent with this model, NECAPs preferentially bind open and phosphorylated forms of AP2 in vitro and localize with constitutively open AP2 mutants in vivo. NECAPs do not associate with phosphorylation-defective AP2 mutants, implying that phosphorylation precedes NECAP recruitment. We propose NECAPs function late in endocytosis to inactivate AP2. © 2018, Beacham et al.

APS extends open access to all its journals

CERN Multimedia

Thomas, Kim

2006-01-01

"Physics research promoter and publisher the American Physical Society (APS) is to extend open access to all its journals. Th APS previously made its five print journals available through subscriptions, and its two e-journals (Physical Review Special Topics and Physics Educatoin Research) on an open access basis." (1/2 page)

The Role of AP and the Composition Program.

Science.gov (United States)

Mahala, Daniel; Vivion, Michael

1993-01-01

Suggests that most programs have not based their acceptance of advanced placement credit on reasoned endorsement of the views of language, literature, and rhetoric that AP exams present. Criticizes the views implicit in the AP program and shows how they conflict with the goals of one particular college composition program. (RS)

SEPTUM MAGNET DESIGN FOR THE APS-U

Energy Technology Data Exchange (ETDEWEB)

Abliz, M.; Jaski, M.; Xiao, A.; Wienands, U.; Cease, H.; Borland, M.; Decker, G.; Kerby, J.

2017-06-25

The Advanced Photon Source is in the process of upgrading its storage ring from a double-bend to a multi-bend lattice as part of the APS Upgrade Project (APS-U). A swap-out injection scheme is planned for the APS-U to keep a constant beam current and to enable a small dynamic aperture. A septum magnet with a minimum thickness of 2 mm and an injection field of 1.06 T has been designed, delivering the required total deflecting angle is 89 mrad with a ring energy of 6 GeV. The stored beam chamber has an 8 mm x 6 mm super-ellipsoidal aperture. The magnet is straight; however, it is tilted in yaw, roll, and pitch from the stored beam chamber to meet the on axis swap out injection requirements for the APS-U lattice. In order to minimize the leakage field inside the stored beam chamber, four different techniques were utilized in the design. As a result, the horizontal deflecting angle of the stored beam was held to only 5 µrad, and the integrated skew quadrupole inside the stored beam chamber was held to 0.09 T. The detailed techniques that were applied to the design, field multipoles, and resulting trajectories of the injected and stored beams are reported.

Views of School Counselors and Social Service Workers on the Role of School in the Protection of Children in Care

Directory of Open Access Journals (Sweden)

Davut ELMACI

2017-12-01

Full Text Available The purpose of this research is to determine the views of the school counselors and social service workers about the role of the school in the protection of children in care. The participants of the research, designed as qualitative research, composed of the school counselors working at primary schools where children in care attend in the TR83 region (Amasya, Çorum, Samsun, and Tokat and the social service workers in the same region. In this scope, interviews were conducted with 11 school counselors and 12 social service workers. Research findings show that the role of school is beneficial for socializing children in care. The main problems encountered in fulfilling the current role of the school in the protection of children in care are; behavioral problems of children in care, inadequate communication between the school and the social service institution, the past problems that the children in care experienced, the school staff’s lack of knowledge about children in care and labeling. According to the research results, it is beneficial to raise awareness of school administrators and teachers about child protection and to establish an effective cooperation between school and social service institution.

How do migratory species add ecosystem service value to wilderness? Calculating the spatial subsidies provided by protected areas

Science.gov (United States)

Lopez-Hoffman, Laura; Semmens, Darius J.; Diffendorfer, Jay

2013-01-01

Species that migrate through protected and wilderness areas and utilize their resources, deliver ecosystem services to people in faraway locations. The mismatch between the areas that most support a species and those areas where the species provides most benefits to society can lead to underestimation of the true value of protected areas such as wilderness. We present a method to communicate the “off-site” value of wilderness and protected areas in providing habitat to migratory species that, in turn, provide benefits to people in distant locations. Using northern pintail ducks (Anas acuta) as an example, the article provides a method to estimate the amount of subsidy – the value of the ecosystem services provided by a migratory species in one area versus the cost to support the species and its habitat elsewhere.

AP@home: a novel European approach to bring the artificial pancreas home.

Science.gov (United States)

Heinemann, Lutz; Benesch, Carsten; DeVries, J Hans

2011-11-01

The development of an artificial pancreas (AP) made huge strides from 2006 to 2008 and a large number of activities are going on in this area of research. Until now, most AP systems under development were tested only under highly controlled conditions. The aim of our project, funded by the European Union, is to develop an AP system to such a level that it can be studied under daily life conditions at the home of patients with diabetes (hence AP@home). Based on a subcutaneous-subcutaneous closed-loop strategy (i.e., glucose sensing and insulin infusion in the subcutaneous tissue), two different approaches will be taken to achieve this aim: a two-port AP system and a single-port AP system. The two-port AP system will use off-the-shelf-components for the glucose sensor and insulin pump in combination with closed-loop algorithms generated in Europe. As to the single-port AP system, two different innovative single-port systems will be developed; in this case, continuous glucose monitoring and insulin infusion will take place via a single catheter. The first clinical trials with the two-port AP system under controlled clinical conditions have started and good progress has been made in the development of the single-port AP systems. We believe that our consortium of 12 European partners, which builds on existing achievements and close cooperation between academic centers and industry, can contribute substantially to the development of an AP system that can be used by patients in daily life. © 2011 Diabetes Technology Society.

The power of simplification: Operator interface with the AP1000R during design-basis and beyond design-basis events

International Nuclear Information System (INIS)

Williams, M. G.; Mouser, M. R.; Simon, J. B.

2012-01-01

The AP1000 R plant is an 1100-MWe pressurized water reactor with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance, safety and cost. The passive safety features are designed to function without safety-grade support systems such as component cooling water, service water, compressed air or HVAC. The AP1000 passive safety features achieve and maintain safe shutdown in case of a design-basis accident for 72 hours without need for operator action, meeting the expectations provided in the European Utility Requirements and the Utility Requirement Document for passive plants. Limited operator actions may be required to maintain safe conditions in the spent fuel pool (SFP) via passive means. This safety approach therefore minimizes the reliance on operator action for accident mitigation, and this paper examines the operator interaction with the Human-System Interface (HSI) as the severity of an accident increases from an anticipated transient to a design basis accident and finally, to a beyond-design-basis event. The AP1000 Control Room design provides an extremely effective environment for addressing the first 72 hours of design-basis events and transients, providing ease of information dissemination and minimal reliance upon operator actions. Symptom-based procedures including Emergency Operating Procedures (EOPs), Abnormal Operating Procedures (AOPs) and Alarm Response Procedures (ARPs) are used to mitigate design basis transients and accidents. Use of the Computerized Procedure System (CPS) aids the operators during mitigation of the event. The CPS provides cues and direction to the operators as the event progresses. If the event becomes progressively worse or lasts longer than 72 hours, and depending upon the nature of failures that may have occurred, minimal operator actions may be required outside of the control room in areas that have been designed to be accessible using components that have been designed

AP1000: Meeting economic goals in a competitive world. Annex 7

International Nuclear Information System (INIS)

Davis, G.; Cummins, E.; Winters, J.

2002-01-01

In the U.S., conditions are becoming more favorable for considering the nuclear option again for new baseload generation. While oil and natural gas prices have risen, the cost of operating the existing fleet of nuclear plants has decreased. Furthermore, an advanced 1000 MWe nuclear plant that will be even more cost-competitive with fossil fuels and natural gas will be available by 2005. Westinghouse, in an effort to further improve on the AP600's cost competitiveness, has developed the AP1000, a two-loop, 1000 MWe, advanced pressurized water reactor (PWR) with passive safety features and extensive plant simplifications to enhance the construction, operation, and maintenance. Like the AP600, the AP1000 uses proven technology that builds on over 30 years of operating PWR experience. Westinghouse has completed design studies that demonstrate that it is feasible to increase the power output of the AP600 to at least 1000 MWe, maintaining its current design configuration and licensing basis. To maximize the cost savings, the AP1000 has been designed within the space constraints of the AP600, while retaining the credibility of proven components and substantial safety margins. The affect on the plant's overnight cost of the increased major components that is required to uprate the AP600 to 1000 MWe is small. This overall cost addition is on the order of 11 percent, while the overall power increase is almost 80 percent. This paper describes the changes made to uprate the AP600 and gives an overview of the plant design. (author)

History of the APS Topical Group on Shock Compression of Condensed Matter

International Nuclear Information System (INIS)

Forbes, J W

2001-01-01

In order to provide broader scientific recognition and to advance the science of shock compressed condensed matter, a group of American Physical Society (APS) members worked within the Society to make this field an active part of the APS. Individual papers were presented at APS meetings starting in the 1940's and shock wave sessions were organized starting with the 1967 Pasadena meeting. Shock wave topical conferences began in 1979 in Pullman, WA. Signatures were obtained on a petition in 1984 from a balanced cross-section of the shock wave community to form an APS Topical Group (TG). The APS Council officially accepted the formation of the Shock Compression of Condensed Matter (SCCM) TG at its October 1984 meeting. This action firmly aligned the shock wave field with a major physical science organization. Most early topical conferences were sanctioned by the APS while those held after 1992 were official APS meetings. The topical group organizes a shock wave topical conference in odd numbered years while participating in shock wavehigh pressure sessions at APS general meetings in even numbered years

O tratamento contabilístico dos ativos intangíveis: SNC versus SNC-AP

OpenAIRE

Silva, Lurdes; Rua, Susana; Quesado, Patrícia

2016-01-01

The main objective of this work is to carry out a comparative analysis of accounting for intangible assets under SNC and SNC-AP. The convergence of the both normative regarding the recognition and measurement criteria is not fully. With regard to recognition, is given the possibility, in the public ambit, to an element to be recognized as an asset, even that does not produce future economic benefits to the entity, since they have service potential. As the measurement it relates, in the public...

Auricular Chondritis in a Postpartum Flare of SLE and APS

Directory of Open Access Journals (Sweden)

Elodie Ponce

2014-10-01

Full Text Available Introduction: Auricular chondritis has been occasionally described in patients with systemic lupus erythematosus (SLE and antiphospholipid syndrome (APS. Materials and methods: We report the case of a woman with a previous history of APS who presented with auricular chondritis with onset of SLE symptoms during the postpartum period. Conclusion: SLE and APS should be taken into consideration in the differential diagnosis of auricular chondritis.

FRANX. Application for analysis and quantification of the APS fire

International Nuclear Information System (INIS)

Snchez, A.; Osorio, F.; Ontoso, N.

2014-01-01

The FRANX application has been developed by EPRI within the Risk and Reliability User Group in order to facilitate the process of quantification and updating APS Fire (also covers floods and earthquakes). By applying fire scenarios are quantified in the central integrating the tasks performed during the APS fire. This paper describes the main features of the program to allow quantification of an APS Fire. (Author)

The Westinghouse Advanced Passive Pressurized Water Reactor, AP1000

International Nuclear Information System (INIS)

Schene, R.

2009-01-01

Featuring proven technology and innovative passive safety systems, the Westinghouse AP1000 pressurized water reactor can achieve competitive generation costs in the current electricity market without emitting harmful greenhouse gases and further harming the environment. Westinghouse Electric Company, the pioneer in nuclear energy once again sets a new industry standard with the AP1000. The AP1000 is a two-loop pressurized water reactor that uses simplified, innovative and effective approach to safety. With a gross power rating of 3415 megawatt thermal and a nominal net electrical output of 1117 megawatt electric, the AP1000 is ideal for new base load generation. The AP1000 is the safest and most economical nuclear power plant available in the worldwide commercial marketplace, and is the only Generation III+ reactor to receive a design certification from the U.S. Nuclear Regulatory Commission (NRC). Based on nearly 20 years of research and development, the AP1000 builds and improves upon the established technology of major components used in current Westinghouse designed plants. These components, including steam generators, digital instrumentation and controls, fuel, pressurizers, and reactor vessels, are currently in use around the world and have years of proven, reliable operating experience. Historically, Westinghouse plant designs and technology have forged the cutting edge technology of nuclear plant around the world. Today, nearly 50 percent of the world's 440 nuclear plants are based on Westinghouse technology. Westinghouse continues to be the nuclear industry's global leader. (author)

Westinghouse plans global new builds for AP1000

International Nuclear Information System (INIS)

Mitev, Lubomir

2014-01-01

Interview with Danny Roderick, Westinghouse Electric Company, President and Chief Executive Officer since September 2012, about perspectives and future plans for AP1000 new build worldwide. Within three to four years there wille be 'shovels in the ground' for three new AP1000 reactors in the UK, as well as new units in China and Bulgaria. Four AP1000 reactors are under construction in the United States at Vogtle and VC Summer, and soon at Turkey Point. Additionally Danny Roderick spoke about the acquisition of NuGen, technology transfer, the influence of the Ukraine crises on the nuclear market in East Europe and the future need for more nuclear worldwide and in the UK and Bulgaria.

Westinghouse plans global new builds for AP1000

Energy Technology Data Exchange (ETDEWEB)

Mitev, Lubomir [NucNet, Brussels (Belgium)

2014-10-15

Interview with Danny Roderick, Westinghouse Electric Company, President and Chief Executive Officer since September 2012, about perspectives and future plans for AP1000 new build worldwide. Within three to four years there wille be 'shovels in the ground' for three new AP1000 reactors in the UK, as well as new units in China and Bulgaria. Four AP1000 reactors are under construction in the United States at Vogtle and VC Summer, and soon at Turkey Point. Additionally Danny Roderick spoke about the acquisition of NuGen, technology transfer, the influence of the Ukraine crises on the nuclear market in East Europe and the future need for more nuclear worldwide and in the UK and Bulgaria.

A new gap separation mechanism for APS insertion devices

International Nuclear Information System (INIS)

Trakhtenberg, E. M.; Tcheskidov, V.; Den Hartog, P. K.; Deriy, B.; Erdmann, M.; Makarov, O.; Moog, E. R.

1999-01-01

A new gap separation mechanism for use with the standard Advanced Photon Source (APS) 3.3-cm-period undulator magnetic structures has been designed and built and the first system has been installed in the APS storage ring. The system allows a minimum magnetic gap of 10 mm for use with the APS 8-mm insertion device vacuum chambers. The mechanism is a bolted steel frame structure with a simple 4-motor mechanical drive train. The control system uses servomotors with incremental rotary encoders and virtual absolute linear encoders

AP600 design certification thermal hydraulics testing and analysis

Energy Technology Data Exchange (ETDEWEB)

Hochreiter, L.E.; Piplica, E.J.

1995-09-01

Westinghouse Electric Corporation, in conjunction with the Department of Energy and the Electric Power Research Institute, have been developing an advanced light water reactor design; the AP600. The AP600 is a 1940 Mwt, 600Mwe unit which is similar to a Westinghouse two-loop Pressurized Water Reactor. The accumulated knowledge on reactor design to reduce the capital costs, construction time, and the operational and maintenance cost of the unit once it begins to generate electrical power. The AP600 design goal is to maintain an overall cost advantage over fossil generated electrical power.

The APS SASE FEL: modeling and code comparison

International Nuclear Information System (INIS)

Biedron, S. G.

1999-01-01

A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL

Childhood Maltreatment and Child Protective Services Involvement Among the Commercially Sexually Exploited: A Comparison of Women Who Enter as Juveniles or as Adults.

Science.gov (United States)

Cimino, Andrea N; Madden, Elissa E; Hohn, Kris; Cronley, Courtney M; Davis, Jaya B; Magruder, Karen; Kennedy, M Alexis

2017-04-01

A risk for commercial sexual exploitation is childhood maltreatment. It's unknown whether juveniles in commercial sexual exploitation experience more childhood maltreatment than adults or how involved child protective services is in investigating maltreatment, a focus of this study. Women (N = 96) who sold sex commercially completed a cross-sectional questionnaire. Descriptive statistics, t tests, chi-squares, and odds ratios were used to examine differences in background, childhood maltreatment, and child protective services involvement by juvenile or adult entry. Although 93% of participants experienced child maltreatment, juveniles had increased odds of parent/caregiver sexual abuse, being left alone, being kicked out, and running away from a parent/caregiver. There were no differences in cumulative childhood maltreatment resulting in an investigation or removal, indicating that juveniles not investigated or removed by child protective services had as much childhood maltreatment as juveniles who were investigated or removed by child protective services. Results highlight the need for child welfare staff to recognize childhood maltreatment as risks for commercial sexual exploitation.

Kinetic properties of ATP sulfurylase and APS kinase from Thiobacillus denitrificans.

Science.gov (United States)

Gay, Sean C; Fribourgh, Jennifer L; Donohoue, Paul D; Segel, Irwin H; Fisher, Andrew J

2009-09-01

The Thiobacillus denitrificans genome contains two sequences corresponding to ATP sulfurylase (Tbd_0210 and Tbd_0874). Both genes were cloned and expressed protein characterized. The larger protein (Tbd_0210; 544 residues) possesses an N-terminal ATP sulfurylase domain and a C-terminal APS kinase domain and was therefore annotated as a bifunctional enzyme. But, the protein was not bifunctional because it lacked ATP sulfurylase activity. However, the enzyme did possess APS kinase activity and displayed substrate inhibition by APS. Truncated protein missing the N-terminal domain had APS kinase activity suggesting the function of the inactive sulfurylase domain is to promote the oligomerization of the APS kinase domains. The smaller gene product (Tbd_0874; 402 residues) possessed strong ATP sulfurylase activity with kinetic properties that appear to be kinetically optimized for the direction of APS utilization and ATP+sulfate production, which is consistent with an enzyme that functions physiologically to produce inorganic sulfate.

Control of sulfate concentration by miR395-targeted APS genes in Arabidopsis thaliana

Directory of Open Access Journals (Sweden)

Qin Ai

2016-04-01

Full Text Available Sulfur nutrition is crucial for plant growth and development, as well as crop yield and quality. Inorganic sulfate in the soil is the major sulfur source for plants. After uptake, sulfate is activated by ATP sulfurylase, and then gets assimilated into sulfur-containing metabolites. However, the mechanism of regulation of sulfate levels by ATP sulfurylase is unclear. Here, we investigated the control of sulfate levels by miR395-mediated regulation of APS1/3/4. Sulfate was over-accumulated in the shoots of miR395 over-expression plants in which the expression of the APS1, APS3, and APS4 genes was suppressed. Accordingly, reduced expression of miR395 caused a decline of sulfate concentration. In agreement with these results, over-expression of the APS1, APS3, and APS4 genes led to the reduction of sulfate levels. Differential expression of these three APS genes in response to sulfate starvation implied that they have different functions. Further investigation revealed that the regulation of sulfate levels mediated by miR395 depends on the repression of its APS targets. Unlike the APS1, APS3, and APS4 genes, which encode plastid-localized ATP sulfurylases, the APS2 gene encodes a cytosolic version of ATP sulfurylase. Genetic analysis indicated that APS2 has no significant effect on sulfate levels. Our data suggest that miR395-targeted APS genes are key regulators of sulfate concentration in leaves.

Functional description of APS beamline front ends

International Nuclear Information System (INIS)

Kuzay, T.

1993-02-01

Traditional synchrotron sources were designed to produce bending magnet radiation and have proven to be an essential scientific tool. Currently, a new generation of synchrotron sources is being built that will be able to accommodate a large number of insertion device (ID) and high quality bending magnet (BM) sources. One example is the 7-GeV Advanced Photon Source (APS) now under construction at Argonne National Laboratory. The research and development effort at the APS is designed to fully develop the potential of this new generation of synchrotron sources. Of the 40 straight sections in the APS storage ring, 34 will be available for IDs. The remaining six sections are reserved for the storage ring hardware and diagnostics. Although the ring incorporates 80 BMs, only 40 of them can be used to extract radiation. The accelerator hardware shadows five of these 40 bending magnets, so the maximum number of BM sources on the lattice is 35. Generally, a photon beamline consists of four functional sections. The first section is the ID or the BM, which provides the radiation source. The second section, which is immediately outside the storage ring but inside a concrete shielding tunnel, is the front end, which is designed to control, define, and/or confine the x-ray beam. In the case of the APS, the front ends are designed to confine the photon beam. The third section, just outside the concrete shielding tunnel and on the experimental floor, is the first optics enclosure, which contains optics to filter and monochromatize the photon beam. The fourth section of a beamline consists of beam transports, additional optics, and experiment stations to do the scientific investigations. This document describes only the front ends of the APS beamlines

14 August 1981 - Royal Order on the organization and administrative status of the personnel of the Service for Protection against Ionizing Radiation

International Nuclear Information System (INIS)

1981-01-01

This Order concerns the organization and the administrative structure of the Service for Protection against Ionizing Radiations. The Service, within the Ministry of Public Health and the Family, is responsible, inter alia, for controlling the application of legislation on radiation protection, for examining licensing applications for nuclear facilities and import and transport of radioactive substances. (NEA) [fr

Thrombotic recurrences and bleeding events in APS vascular patients: a review from the literature and a comparison with the APS Piedmont Cohort.

Science.gov (United States)

Bazzan, M; Vaccarino, A; Stella, S; Bertero, M T; Carignola, R; Montaruli, B; Roccatello, D; Shoenfeld, Y

2013-06-01

In APS vascular patients, thrombotic recurrences are more frequent than in non-APS thrombotic patients. To better define this clinical setting, a systematic review of the literature after 1999 was performed: 8 cohort studies (including the recent APS Piedmont Cohort) and 6 intervention studies were selected and evaluated. Thrombotic recurrences, bleeding events, therapeutic strategies, antiphospholipid (aPL) profile, inherited and acquired risk factors (when present) were calculated and compared. Emerging risk factors for thrombotic recurrences include withdrawal of oral anticoagulant therapy (OAT), high intensity OAT (INR range 3-4), aPL profile (triple positivity, Miyakis types 1 and 2a profiles) and association with inherited or acquired pro-thrombotic risk factors. Moreover, there are evidences that high risk (mainly for aPL profile) APS vascular patients have a high recurrence rate in spite of correct OAT treatment. Clinical trials in this clinical setting are needed. Copyright © 2012 Elsevier B.V. All rights reserved.

AP1000{sup R} licensing and deployment in the United States

Energy Technology Data Exchange (ETDEWEB)

Jordan, R. P.; Russ, P. A.; Filiak, P. P.; Castiglione, L. L. [Westinghouse Electric Company LLC, 1000 Westinghouse Drive, Cranberry Township, PA 16066 (United States)

2012-07-01

In recent years, both domestic and foreign utilities have turned to the standardized Westinghouse AP1000 plant design in satisfying their near - and long-term - sustainable energy needs. As direct support to these actions, licensing the AP1000 design has played a significant role by providing one of the fundamental bases in clearing regulatory hurdles leading to the start of new plant construction. Within the U.S. alone, Westinghouse AP1000 licensing activities have reached unprecedented milestones with the approvals of both AP1000 Design Certification and Southern Company's combined construction permit and operating license (COL) application directly supporting the construction of two new nuclear plants in Georgia. Further COL application approvals are immediately pending for an additional two AP1000 plants in South Carolina. And, across the U.S. nuclear industry spectrum, there are 10 other COL applications under regulatory review representing some 16 new plants at 10 sites. In total, these actions represent the first wave of new plant licensing under the regulatory approval process since 1978. Fundamental to the Nuclear Regulatory Commission's AP1000 Design Certification is the formal recognition of the AP1000 passive safety design through regulatory acceptance rulemaking. Through recognition and deployment of the AP1000 Design Certification, the utility licensee / operator of this reactor design are now offered an opportunity to use a simplified 'one-step' combined license process, thereby managing substantial back-end construction schedule risk from regulatory and intervention delays. Application of this regulatory philosophy represents both acceptance and encouragement of standardized reactor designs like the AP1000. With the recent AP1000 Design Certification and utility COL acceptances, the fundamental licensing processes of this philosophy have successfully proven the attainment of significant milestones with the next stage licensing

Development and validation of the Affect in Play Scale-brief rating version (APS-BR).

Science.gov (United States)

Cordiano, Tori J Sacha; Russ, Sandra W; Short, Elizabeth J

2008-01-01

The Affect in Play Scale (APS; Russ, 1987, 2004) is one of few reliable, standardized measures of pretend play, yet the fact that it requires videotaping and extensive training to score compromises its clinical utility. In this study, we developed and validated a brief rating version (APS-BR) that does not require videotaping. Construct validity was established by comparing scores from the original APS and the APS-BR using an existing data set of videotaped play (n = 46). We examined associations between scores on the APS-BR and theoretically relevant measures of divergent thinking and emotional memories. Scores on the APS-BR related strongly to those on the APS, and the pattern of correlations for each scale and relevant criterion measures was similar in strength and direction, supporting the APS-BR as an alternate form of the APS. In addition, we completed a pilot study to examine the efficacy of using the APS-BR in its intended in vivo format (n = 28). Results from both studies suggest that the APS-BR is a promising brief measure of children's pretend play that can be substituted for the APS in clinical and research settings.

Radioactive air emissions notice of construction for installation and operation of a waste retrieval system and tanks 241-AP-102 and 241-AP-104 project

Energy Technology Data Exchange (ETDEWEB)

DEXTER, M.L.

1999-11-15

This document serves as a notice of construction (NOC) pursuant to the requirements of Washington Administrative Code (WAC) 246 247-060, and as a request for approval to modify pursuant to 40 Code of Federal Regulations (CFR) 61 07 for the installation and operation of one waste retrieval system in the 24 1 AP-102 Tank and one waste retrieval system in the 241 AP 104 Tank Pursuant to 40 CFR 61 09 (a)( 1) this application is also intended to provide anticipated initial start up notification Its is requested that EPA approval of this application will also constitute EPA acceptance of the initial start up notification Project W 211 Initial Tank Retrieval Systems (ITRS) is scoped to install a waste retrieval system in the following double-shell tanks 241-AP 102-AP 104 AN 102, AN 103, AN-104, AN 105, AY 102 AZ 102 and SY-102 between now and the year 2011. Because of the extended installation schedules and unknowns about specific activities/designs at each tank, it was decided to submit NOCs as that information became available This NOC covers the installation and operation of a waste retrieval system in tanks 241 AP-102 and 241 AP 104 Generally this includes removal of existing equipment installation of new equipment and construction of new ancillary equipment and buildings Tanks 241 AP 102 and 241 AP 104 will provide waste feed for immobilization into a low activity waste (LAW) product (i.e. glass logs) The total effective dose equivalent (TEDE) to the offsite maximally exposed individual (MEI) from the construction activities is 0 045 millirem per year The unabated TEDE to the offsite ME1 from operation of the mixer pumps is 0 042 millirem per year.

Radioactive air emissions notice of construction for installation and operation of a waste retrieval system and tanks 241-AP-102 and 241-AP-104 project

International Nuclear Information System (INIS)

DEXTER, M.L.

1999-01-01

This document serves as a notice of construction (NOC) pursuant to the requirements of Washington Administrative Code (WAC) 246 247-060, and as a request for approval to modify pursuant to 40 Code of Federal Regulations (CFR) 61 07 for the installation and operation of one waste retrieval system in the 24 1 AP-102 Tank and one waste retrieval system in the 241 AP 104 Tank Pursuant to 40 CFR 61 09 (a)( 1) this application is also intended to provide anticipated initial start up notification Its is requested that EPA approval of this application will also constitute EPA acceptance of the initial start up notification Project W 211 Initial Tank Retrieval Systems (ITRS) is scoped to install a waste retrieval system in the following double-shell tanks 241-AP 102-AP 104 AN 102, AN 103, AN-104, AN 105, AY 102 AZ 102 and SY-102 between now and the year 2011. Because of the extended installation schedules and unknowns about specific activities/designs at each tank, it was decided to submit NOCs as that information became available This NOC covers the installation and operation of a waste retrieval system in tanks 241 AP-102 and 241 AP 104 Generally this includes removal of existing equipment installation of new equipment and construction of new ancillary equipment and buildings Tanks 241 AP 102 and 241 AP 104 will provide waste feed for immobilization into a low activity waste (LAW) product (i.e. glass logs) The total effective dose equivalent (TEDE) to the offsite maximally exposed individual (MEI) from the construction activities is 0 045 millirem per year The unabated TEDE to the offsite ME1 from operation of the mixer pumps is 0 042 millirem per year

The Dushak–Erekdag Survey of roAp Stars

Indian Academy of Sciences (India)

2016-01-27

Jan 27, 2016 ... The search of roAp stars at Mt. Dushak–Erekdag Observatory was started in 1992 using the 0.8m Odessa telescope equipped with a two-star high-speed photometer. We have observed more than a dozen stars so far and discovered HD 99563 as roAp star while BD+8087 is suspected to have rapid ...

AP-2α and AP-2β cooperatively orchestrate homeobox gene expression during branchial arch patterning.

Science.gov (United States)

Van Otterloo, Eric; Li, Hong; Jones, Kenneth L; Williams, Trevor

2018-01-25

The evolution of a hinged moveable jaw with variable morphology is considered a major factor behind the successful expansion of the vertebrates. DLX homeobox transcription factors are crucial for establishing the positional code that patterns the mandible, maxilla and intervening hinge domain, but how the genes encoding these proteins are regulated remains unclear. Herein, we demonstrate that the concerted action of the AP-2α and AP-2β transcription factors within the mouse neural crest is essential for jaw patterning. In the absence of these two proteins, the hinge domain is lost and there are alterations in the size and patterning of the jaws correlating with dysregulation of homeobox gene expression, with reduced levels of Emx, Msx and Dlx paralogs accompanied by an expansion of Six1 expression. Moreover, detailed analysis of morphological features and gene expression changes indicate significant overlap with various compound Dlx gene mutants. Together, these findings reveal that the AP-2 genes have a major function in mammalian neural crest development, influencing patterning of the craniofacial skeleton via the DLX code, an effect that has implications for vertebrate facial evolution, as well as for human craniofacial disorders. © 2018. Published by The Company of Biologists Ltd.

Protecting victims of elder financial exploitation: the role of an Elder Abuse Forensic Center in referring victims for conservatorship.

Science.gov (United States)

Gassoumis, Zachary D; Navarro, Adria E; Wilber, Kathleen H

2015-01-01

The aim of this study was to examine the extent to which an Elder Abuse Forensic Center protects financial exploitation (FE) victims through referral to the Office of the Public Guardian (PG) for investigation and possible conservatorship (called 'guardianship' in many states). Los Angeles County Elder Abuse Forensic Center cases involving adults aged 65 and older (April 2007-December 2009) were matched using one-to-one propensity-score matching to 33,650 usual care Adult Protective Services (APS) cases. The final analysis sample consisted of 472 FE cases. Compared to usual care, Forensic Center cases were more likely to be referred to the PG for investigation (30.6%, n = 72 vs. 5.9%, n = 14, p Elder Abuse Forensic Center conceptual model and contribute to an emerging body of evidence on the role of the Forensic Center in addressing elder abuse.

Dietary Calcium and Dairy Modulation of Oxidative Stress and Mortality in aP2-Agouti and Wild-type Mice

Directory of Open Access Journals (Sweden)

Antje Bruckbauer

2009-08-01

Full Text Available Oxidative and inflammatory stress have been implicated as major contributors to the aging process. Dietary Ca reduced both factors in short-term interventions, while milk exerted a greater effect than supplemental Ca. In this work, we examined the effects of life-long supplemental and dairy calcium on lifespan and life-span related biomarkers in aP2-agouti transgenic (model of diet-induced obesity and wild-type mice fed obesigenic diets until their death. These data demonstrate that dairy Ca exerts sustained effects resulting in attenuated adiposity, protection against age-related muscle loss and reduction of oxidative and inflammatory stress in both mouse strains. Although these effects did not alter maximum lifespan, they did suppress early mortality in wild-type mice, but not in aP2-agouti transgenic mice.

Development of a framework based on an ecosystem services approach for deriving specific protection goals for environmental risk assessment of pesticides

DEFF Research Database (Denmark)

Forbes, Valery E.; Nienstedt, Karin M.; Brock, T. C. M.

2012-01-01

General protection goals for the environmental risk assessment (ERA) of plant protection products are stated in European legislation but specific protection goals (SPGs) are often not precisely defined. These are however crucial for designing appropriate risk assessment schemes. The process...... followed by the Panel on Plant Protection Products and their Residues (PPR) of the European Food Safety Authority (EFSA) as well as examples of resulting SPGs obtained so far for environmental risk assessment (ERA) of pesticides is presented. The ecosystem services approach was used as an overarching...... and geographical scale of the effect, and the degree of certainty that the specified level of effect will not be exceeded. In general, to ensure ecosystem services, taxa representative for the key drivers identified need to be protected at the population level. However, for some vertebrates and species that have...

Refer to AP1000 for discussing the betterment of seismic design of internal nuclear power plant

International Nuclear Information System (INIS)

Gong Zhenbang; Zhang Renyan

2014-01-01

As a reference technique of AP1000, This paper discussed the betterment of seismic design of nuclear power plant in three ways. (1) Establish design criteria and guidelines for protection from seismic interaction; (2) Nuclear power plant seismic design of eliminating or weaken operation-basis earthquake; (3) Develop the seismic margin analysis (SMA) of the nuclear power plant. These three aspect are frontier technology in internal seismic design of internal nuclear power plant, and also these three technology are related intimately. (authors)

The power of simplification: Operator interface with the AP1000{sup R} during design-basis and beyond design-basis events

Energy Technology Data Exchange (ETDEWEB)

Williams, M. G.; Mouser, M. R.; Simon, J. B. [Westinghouse Electric Company, 1000 Westinghouse Drive, Cranberry Township, PA 16066 (United States)

2012-07-01

The AP1000{sup R} plant is an 1100-MWe pressurized water reactor with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance, safety and cost. The passive safety features are designed to function without safety-grade support systems such as component cooling water, service water, compressed air or HVAC. The AP1000 passive safety features achieve and maintain safe shutdown in case of a design-basis accident for 72 hours without need for operator action, meeting the expectations provided in the European Utility Requirements and the Utility Requirement Document for passive plants. Limited operator actions may be required to maintain safe conditions in the spent fuel pool (SFP) via passive means. This safety approach therefore minimizes the reliance on operator action for accident mitigation, and this paper examines the operator interaction with the Human-System Interface (HSI) as the severity of an accident increases from an anticipated transient to a design basis accident and finally, to a beyond-design-basis event. The AP1000 Control Room design provides an extremely effective environment for addressing the first 72 hours of design-basis events and transients, providing ease of information dissemination and minimal reliance upon operator actions. Symptom-based procedures including Emergency Operating Procedures (EOPs), Abnormal Operating Procedures (AOPs) and Alarm Response Procedures (ARPs) are used to mitigate design basis transients and accidents. Use of the Computerized Procedure System (CPS) aids the operators during mitigation of the event. The CPS provides cues and direction to the operators as the event progresses. If the event becomes progressively worse or lasts longer than 72 hours, and depending upon the nature of failures that may have occurred, minimal operator actions may be required outside of the control room in areas that have been designed to be accessible using components that have been

The Protective Effects of Shen-Fu Injection on Experimental Acute Pancreatitis in a Rat Model

Directory of Open Access Journals (Sweden)

Lei Huang

2014-01-01

Full Text Available Objectives. In the present study, we investigated the protective effects of Shen-Fu injection (SFI on a caerulein-induced rat pancreatitis (AP model. Methods. SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies. Results. Our results showed that AP caused significant decrease in tissue glutathione (GSH and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA and myeloperoxidase (MPO were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein. Conclusion. Our findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB activity.

Heterologous expression in Tritrichomonas foetus of functional Trichomonas vaginalis AP65 adhesin

Directory of Open Access Journals (Sweden)

Alderete JF

2005-03-01

Full Text Available Abstract Background Trichomonosis, caused by Trichomonas vaginalis, is the number one, nonviral sexually transmitted infection that has adverse consequences for the health of women and children. The interaction of T. vaginalis with vaginal epithelial cells (VECs, a step preparatory to infection, is mediated in part by the prominent surface protein AP65. The bovine trichomonad, Tritrichomonas foetus, adheres poorly to human VECs. Thus, we established a transfection system for heterologous expression of the T. vaginalis AP65 in T. foetus, as an alternative approach to confirm adhesin function for this virulence factor. Results In this study, we show stable transfection and expression of the T. vaginalis ap65 gene in T. foetus from an episomal pBS-ap65-neo plasmid. Expression of the gene and protein was confirmed by RT-PCR and immunoblots, respectively. AP65 in transformed T. foetus bound to host cells. Specific mAbs revealed episomally-expressed AP65 targeted to the parasite surface and hydrogenosome organelles. Importantly, surface-expression of AP65 in T. foetus paralleled increased levels of adherence of transfected bovine trichomonads to human VECs. Conclusion The T. vaginalis AP65 adhesin was stably expressed in T. foetus, and the data obtained using this heterologous system strongly supports the role of AP65 as a prominent adhesin for T. vaginalis. In addition, the heterologous expression in T. foetus of a T. vaginalis gene offers an important, new approach for confirming and characterizing virulence factors.

A Seamless Handoff Scheme with Access Point Load Balance for Real-Time Services Support in 802.11 Wireless LANs

Science.gov (United States)

Manodham, Thavisak; Loyola, Luis; Miki, Tetsuya

IEEE 802.11 wirelesses LANs (WLANs) have been rapidly deployed in enterprises, public areas, and households. Voice-over-IP (VoIP) and similar applications are now commonly used in mobile devices over wireless networks. Recent works have improved the quality of service (QoS) offering higher data rates to support various kinds of real-time applications. However, besides the need for higher data rates, seamless handoff and load balancing among APs are key issues that must be addressed in order to continue supporting real-time services across wireless LANs and providing fair services to all users. In this paper, we introduce a novel access point (AP) with two transceivers that improves network efficiency by supporting seamless handoff and traffic load balancing in a wireless network. In our proposed scheme, the novel AP uses the second transceiver to scan and find neighboring STAs in the transmission range and then sends the results to neighboring APs, which compare and analyze whether or not the STA should perform a handoff. The initial results from our simulations show that the novel AP module is more effective than the conventional scheme and a related work in terms of providing a handoff process with low latency and sharing traffic load with neighbor APs.

Radiation protection on nuclear medicine services

International Nuclear Information System (INIS)

Anon

2000-01-01

Nuclear medicine is a sector of the medicine that studies and applies radionuclide in diagnosis and therapy. Nuclear medicine is a very specific area of the medicine, making use of non-sealed radioactive sources which are prescribed to the patient orally or are injected. Special procedures in radiation protection are required in nuclear medicine to manipulate these kind of sources and to produce technetium-99m through molybdenum generator. The present paper addresses the them radiation protection in a Nuclear Medicine Department (NMD), showing the main requirements of the CNEN- National Commission of Nuclear Energy and the Public Health. Radiation protection procedures adopted in assembling a NMD, as well the daily techniques for monitoring and for individual dosimetry are discussed. Past and present analyses in a level of radiation protection are presented. (author)

COBRA1 inhibits AP-1 transcriptional activity in transfected cells

International Nuclear Information System (INIS)

Zhong Hongjun; Zhu Jianhua; Zhang Hao; Ding Lihua; Sun Yan; Huang Cuifen; Ye Qinong

2004-01-01

Mutations in the breast cancer susceptibility gene (BRCA1) account for a significant proportion of hereditary breast and ovarian cancers. Cofactor of BRCA1 (COBRA1) was isolated as a BRCA1-interacting protein and exhibited a similar chromatin reorganizing activity to that of BRCA1. However, the biological role of COBRA1 remains largely unexplored. Here, we report that ectopic expression of COBRA1 inhibited activator protein 1 (AP-1) transcriptional activity in transfected cells in a dose-dependent manner, whereas reduction of endogenous COBRA1 with a small interfering RNA significantly enhanced AP-1-mediated transcriptional activation. COBRA1 physically interacted with the AP-1 family members, c-Jun and c-Fos, and the middle region of COBRA1 bound to c-Fos. Lack of c-Fos binding site in the COBRA1 completely abolished the COBRA1 inhibition of AP-1 trans-activation. These findings suggest that COBRA1 may directly modulate AP-1 pathway and, therefore, may play important roles in cell proliferation, differentiation, apoptosis, and oncogenesis

Incorporating Ninth-Grade PSAT/NMSQT® Scores into AP Potential™ Predictions for AP® European History and AP World History. Statistical Report 2014-1

Science.gov (United States)

Zhang, Xiuyuan; Patel, Priyank; Ewing, Maureen

2015-01-01

Historically, AP Potential™ correlations and expectancy tables have been based on 10th-and 11th-grade PSAT/NMSQT® examinees and 11th-and 12th-grade AP® examinees for all subjects (Zhang, Patel, & Ewing,2014; Ewing, Camara, & Millsap, 2006; Camara & Millsap, 1998). However, a large number of students take AP European History and AP…

AP@home: The Artificial Pancreas Is Now at Home

NARCIS (Netherlands)

Heinemann, Lutz; Benesch, Carsten; DeVries, J. Hans

2016-01-01

In the past years the development of an artificial pancreas (AP) has made great progress and many activities are ongoing in this area of research. The major step forward made in the last years was moving the evaluation of AP systems from highly controlled experimental conditions to daily life

AP: A Critical Examination of the Advanced Placement Program

Science.gov (United States)

Sadler, Philip M.; Sonnert, Gerhard; Tai, Robert; Klopfenstein, Kirstin

2016-01-01

The Advanced Placement (AP) program was created to enhance the experience of gifted students as they transition from high school to college. "AP: A Critical Examination of the Advanced Placement Program," edited by Philip M. Sadler, Gerhard Sonnert, Robert Tai, and Kirstin Klopfenstein (2010, Harvard Education Press), questions the…

Fire protection for telecommunications central offices

International Nuclear Information System (INIS)

McKenna, L.A. Jr.

1990-01-01

The provision of continuous, uninterrupted telecommunications service is vital to modern life. In order to provide uninterrupted service to customers, a service continuity program has been in place with AT and T for many years. This program integrates many different protection strategies and plans, each designed to mitigate one of the many threats to service continuity. The fire protection program implemented within AT and T is a part of this service continuity program. In the design of this program, a number of unusual problems had to be addressed due to the service continuity requirements. Typical solutions to fire protection problems (ignition prevention, detection, and suppression) which are embodied in building and fire prevention codes are inadequate to provide service continuity. This presentation outlines the basic arrangement of a telecommunications central office, the specific fire protection problems encountered, the fire protection philosophy developed through the use of a systems approach, and the implementation of the fire protection program. Special emphasis is placed on the strategies employed in lieu of more traditional fire protection schemes and the stimuli for selecting them

Microscopic analysis of dog dental pulp after pulpotomy and pulp protection with mineral trioxide aggregate and white Portland cement Análise microscópica da polpa dental de cães após pulpotomia e proteção pulpar com agregado de trióxido mineral e cimento Portland branco

Directory of Open Access Journals (Sweden)

Renato Menezes

2004-06-01

Full Text Available Considering previous studies on the similarity between the chemical composition of the mineral trioxide aggregate and the Portland cement, the purpose of this study was to investigate the pulp response of dog's teeth after pulpotomy and direct pulp protection with MTA Angelus and white Portland cement. Thirty eight pulp remnants were protected with these materials. One hundred and twenty days after treatment, the animals were sacrificed and the specimens removed and prepared for histological analysis. Both materials demonstrated the same results when used as pulp capping materials, inducing hard tissue bridge formation and maintaining pulp vitality in all specimens. The MTA Angelus and the white Portland cement showed to be effective as pulp protection materials following pulpotomy.Considerando estudos anteriores sobre a similaridade entre a composição química do agregado de trióxido mineral e o cimento Portland, o objetivo deste estudo foi investigar a resposta pulpar de dentes de cães após pulpotomia e proteção pulpar direta com MTA Angelus e cimento Portland branco. Trinta e oito remanescentes pulpares foram recobertos com esses materiais. Cento e vinte dias após o tratamento, os animais foram sacrificados e os espécimes removidos e preparados para análise histológica. Ambos os materiais demonstraram os mesmos resultados quando utilizados como materiais de capeamento pulpar, induzindo a formação de ponte de tecido mineralizado e mantendo a vitalidade pulpar em todos os espécimes. Ambos matérias se mostraram efetivos como protetores pulpares após pulpotomia em dentes de cães.

European utility requirements (EUR) volume 3 assessment for AP1000

International Nuclear Information System (INIS)

Saiu, G.; Demetri, K.J.

2005-01-01

The EUR (European Utility Requirements) Volume 3 is intended to report the Plant Description, the Compliance Assessment to EUR Volumes 1 and 2, and finally, the Specific Requirements for each specific Nuclear Power Plant Design considered by the EUR. Five subsets of EUR Volume 3, based on EUR Revision B, are already published; all of which are next generation plant designs being developed for Europe beyond 2000. They include : 1) EP1000 - Passive Pressurized Light Water Reactor (3-Loop, 1000 MWe) 2) EPR - Evolutionary Pressurized Light Water Reactor (1500 MWe) 3) BWR90/90+ - Evolutionary Boiling Water Reactor (1400 MWe) 4) ABWR - Evolutionary Boiling Water Reactor (1400 MWe) 5) SWR 1000 - Boiling Water Reactor With Passive Features (1000 MWe) In addition, the following subsets are currently being developed: 1) AP1000 - Passive Pressurized Light Water Reactor (2-Loop, 1117 MWe) 2) VVER AES 92 - Pressurized Water Reactor With Passive Features (1000 MWe) The purpose of this paper is to provide an overview of the program, which started in January 2004 with the EUR group to prepare an EUR Volume 3 Subset for the AP1000 nuclear plant design. The AP1000 EUR compliance assessment, to be performed against EUR Revision C requirements, is an important step for the evaluation of the AP1000 design for application in Europe. The AP1000 compliance assessment is making full use of AP1000 licensing documentation, EPP Phase 2 design activities and EP1000 EUR detailed compliance assessment. As of today, nearly all of the EUR Chapters have been discussed within the EUR Coordination Group. Based on the results of the compliance assessment, it can be stated that the AP1000 design shows a good level of compliance with the EUR Revision C requirements. Nevertheless, the compliance assessment has highlighted areas for where the AP1000 plant deviates from the EUR. The EPP design group has selected the most significant ones for performing detailed studies to quantify the degree of compliance

The industrial radiography service in Brazil concerning to the radiation protection aspect

International Nuclear Information System (INIS)

Martins, M.M.

1994-01-01

A study about the industrial radiography situation in Brazil, concerning to the radiation protection aspects is shown. With this purpose it was made an inventory, with utilization of the file of facilities officially registered in industrial application from Brazilian Nuclear Energy Commission (CNEN). It was evaluated the quantity of accelerators), radiation monitors and radiation workers (health physics, operator). As quality and performance indicators of radiation protection the mean doses and the collective doses were used, and their variation from 1987 to 1990. As deficiency signals of radiological protection programs and procedures were utilized the 175 abnormal event occurred (radiological accident and emergency situation) from 1976 to 1992, after an analysis of their causes. The results showed that, for around 2000 monitored workers, the mean dose equivalent was between 0.83 to 2.70 mSv, and the collective dose, between 1.54 and 6.18 Sv.man, from 1987 to 1990. In this period, it was verified a tendency for reduction of means dose and collective dose values. It indicates a possible improvement of radiation protection services or an influence of economical situation of the country. From 175 abnormal events analysed, 456 persons were exposed, with 7.2% of them receiving doses above 50 mSv. These results were compared with those from others countries, such as United Kingdom and united States. (author). 76 refs, 16 figs, 24 tabs

An Asset Protection Scheme for Banks Exposed to Troubled Loan Portfolios

DEFF Research Database (Denmark)

Grosen, Anders; Jessen, Pernille; Kokholm, Thomas Sander

contract with an appropriate structure of incentives. Within the structural credit risk modeling framework, we apply two alternative multivariate default risk models; the classical Gaussian Merton model and a model based on Normal Inverse Gaussian (NIG) processes. Exchanging the normal factors......We examine a specific portfolio credit derivative, an Asset Protection Scheme (APS), and its applicability as a tool to restore financial stability and reduce asymmetric information. As opposed to most governmental bailout packages implemented across the world recently, the APS can be a fair valued...

An Asset Protection Scheme for Banks Exposed to Troubled Loan Portfolios

DEFF Research Database (Denmark)

Kokholm, Thomas

contract with an appropriate structure of incentives. Within the structural credit risk modeling framework, we apply two alternative multivariate default risk models: the classical Gaussian Merton model and a model based on Normal Inverse Gaussian (NIG) processes. Exchanging the normal factors......We examine a specific portfolio credit derivative, an Asset Protection Scheme (APS), and its applicability as a tool to restore financial stability and reduce asymmetric information. As opposed to most governmental bailout packages implemented across the world recently, the APS can be a fair valued...

Special address by the Director of the Federal Radiation Protection Service, Prof. Akin Ojo at the opening ceremony of the national workshop on radiation protection and quality control in medical and industrial practices FRPS, Ibadan on Monday 15 November 1999

International Nuclear Information System (INIS)

Ojo, A.

1999-01-01

A special address by the Director of the Federal Radiation Protection Service, Prof. Akin Ojo at the opening ceremony of the national workshop on radiation protection and quality control in medical and industrial practices held at the Federal Radiation Protection Service, Physics Dept. University of Ibadan from Monday 15 to Friday 19 November 1999

Autoimmune polyglandular syndrome type 3 (APS-3) among patients with premature ovarian insufficiency (POI).

Science.gov (United States)

Szlendak-Sauer, Katarzyna; Jakubik, Daniel; Kunicki, Michał; Skórska, Jolanta; Smolarczyk, Roman

2016-08-01

Autoimmune polyglandular syndrome type 3 - (APS-3), is defined as the coexistence of autoimmune thyroiditis with other non-ovarian autoimmune diseases without primary adrenal insufficiency. Additionally the definition of APS-3 also includes primary ovarian insufficiency (POI) coexistence with autoimmune thyroiditis. The main goal of that study is to assess the prevalence of APS-3 defined as coexistence of autoimmune thyroiditis with POI in population of 46 XX karyotype women with primary ovarian insufficiency (POI). The second goal is to investigate hormonal profile and insulin sensitivity in women with POI and subgroups of women with APS-3 - POI/APS-3(+) and without APS 3 - POI/APS-3(-). Anthropometric measurements, coexistence of autoimmune diseases, androgens, fasting glucose and insulin, glucose and insulin at 60' and 120' of oral glucose tolerance test (OGTT) and homeostasis model for insulin resistance (HOMA-IR), were determine in 98 patients aged between 18 and 39 with spontaneous 46 XX primary ovarian insufficiency (POI), in 33 POI/APS-3(+), 65 POI/APS-3(-), and 75 healthy controls. Continuous data were summarized by the mean±standard deviation (SD), and categorical data by number (percentages). Data were checked for normality using Shapiro-Wilk test, the comparison between groups were performed using non-parametric Mann-Whitney or Kruskall-Wallis test. Pearson's correlation coefficient was used to assess the relationships between parameters. Statistical significance was defined as p values APS-3(+) and POI/APS-3(-) showed significantly lower serum androgens in comparison to controls. Additionally women with POI/APS-3(+) showed hyperinsulinemia after 1h of OGTT; No significant differences in serum fasting glucose, insulin and during 2h OGTT between groups were observed. The prevalence of APS-3 is 33.7% in patients with spontaneous 46 XX primary ovarian insufficiency. Women with POI, POI/APS-3(+) and POI/APS-3(-) feature lower testosterone, androstendione

MULTI-OBJECTIVE ONLINE OPTIMIZATION OF BEAM LIFETIME AT APS

Energy Technology Data Exchange (ETDEWEB)

Sun, Yipeng

2017-06-25

In this paper, online optimization of beam lifetime at the APS (Advanced Photon Source) storage ring is presented. A general genetic algorithm (GA) is developed and employed for some online optimizations in the APS storage ring. Sextupole magnets in 40 sectors of the APS storage ring are employed as variables for the online nonlinear beam dynamics optimization. The algorithm employs several optimization objectives and is designed to run with topup mode or beam current decay mode. Up to 50\\% improvement of beam lifetime is demonstrated, without affecting the transverse beam sizes and other relevant parameters. In some cases, the top-up injection efficiency is also improved.

Shuttle APS propellant thermal conditioner study

Science.gov (United States)

Pearson, W. E.

1971-01-01

A study program was performed to allow selection of thermal conditioner assemblies for superheating O2 and H2 at supercritical pressures. The application was the auxiliary propulsion system (APS) for the space shuttle vehicle. The O2/H2 APS propellant feed system included propellant conditioners, of which the thermal conditioner assemblies were a part. Cryogens, pumped to pressures above critical, were directed to the thermal conditioner assembly included: (1) a gas generator assembly with ignition system and bipropellant valves, which burned superheated O2 and H2 at rich conditions; (2) a heat exchanger assembly for thermal conditioning of the cryogenic propellant; and (3) a dump nozzle for heat exchanger exhaust.

Risk and Protective Factors Associated with Gambling Products and Services: Indigenous Gamblers in North Queensland

Science.gov (United States)

Breen, Helen

2012-01-01

As part of a larger study, this paper reports on findings into risk and protective factors associated with gambling products and services by Indigenous Australians. Both Indigenous card gambling (traditional or unregulated) and commercial gambling (regulated) were investigated. Permission was granted by Indigenous Elders and by a university ethics…

Westinghouse AP1000® PWR: Meeting Customer Commitments and Market Needs

International Nuclear Information System (INIS)

Shulyak, Nick

2014-01-01

Westinghouse Electric Company once again sets a new industry standard with the AP1000 reactor. Historically, Westinghouse plant designs and technology have forged the cutting edge of worldwide nuclear technology. Today, about 50 percent of the world's 440 nuclear plants are based on Westinghouse technology. The AP1000 is the safest and most economical nuclear power plant available in the worldwide commercial marketplace, and is the only Generation III+ reactor to receive Design Certification from the U.S. Nuclear Regulatory Commission (NRC). The AP1000 features proven technology, innovative passive safety systems and offers: Unequalled safety, Economic competitiveness, Improved and more efficient operations. The AP1000 builds and improves upon the established technology of major components used in current Westinghouse-designed plants with proven, reliable operating experience over the past 50 years. These components include: Steam generators, Digital instrumentation and controls, Fuel, Pressurizers, Reactor vessels. Simplification was a major design objective for the AP1000. The simplified plant design includes overall safely systems, normal operating systems, the control room, construction techniques, and instrumentation and control systems. The result is a plant that is easier and less expensive to build, operate and maintain. The AP1000 design saves money and time with an accelerated construction time period of approximately 36 months, from the pouring of first concrete to the loading of fuel. Also, the innovative AP1000 features: 50% fewer safety-related valves, 80% less safety-related piping, 85% less control cable, 35% fewer pumps , 45% less seismic building volume. Eight AP1000 units under construction worldwide-Four units in China-Four units in the United States. (author)

AP Report to the Nation: A Closer Look at the Nation and Florida

Science.gov (United States)

Sawtell, Ellen A.; Gillie, Jacqueline M.; Smith, Patricia Z.

2012-01-01

In February 2012, the College Board published The 8th Annual AP Report to the Nation. This session provides a deeper dive into key information for the United States with an emphasis on Florida, and participants hear how one school in Florida utilizes AP Potential™ to help build their AP Program. Participants also learn about AP participation and…

Flexible receiver adapter and secondary bagger support frame analysis for 241AP102 mixer pump removal

International Nuclear Information System (INIS)

Axup, M.D.; Egger, J.

1995-01-01

As part of the Grout Process startup, the 241AP102 Mixer Pump, failed in 1993, is scheduled to be removed. A structural analysis was performed on two components to be used in the bagging process for the failed pump. The loading criteria was based on a worst case accident of the entire pump weight (including a 50% impact load) being applied over a small localized area. The results show that the design of each structure is adequate to protect against failure, i.e., yield

A Closer Examination of the Academic Benefits of AP

Science.gov (United States)

McKillip, Mary E. M.; Rawls, Anita

2013-01-01

The authors sought to better understand the relationship between students participating in the Advanced Placement (AP) program and subsequent performance on the Scholastic Aptitude Test (SAT). Focusing on students graduating from U.S. public high schools in 2010, the authors used propensity scores to match junior year AP examinees in 3 subjects to…

EVALUATION OF COMMUNITY COMMUNITY SERVICES AND MEDIATION SERVICES INFRINGEMENT OF CHILDREN'S RIGHTS IN THE COMMISSION OF INDONESIAN CHILD PROTECTION

Directory of Open Access Journals (Sweden)

Naswardi Naswardi

2017-12-01

Full Text Available This study aimed to evaluate the service programs of public complaints and mediation of dispute child rights violations in the Indonesian child protection commission (KPAI . Evaluation model used was Discrepancy Evaluation Model (DEM. This study used a qualitative approach. Data collected through observation, interviews, focus groups and internal supporting data. The results showed that the sub-focus research on the Desain of the program resulted in a Skor value of three, it’s means lower inequality. This illustrates that the Desain of the program has been good. Sub focus of the program installation Skord eight, it’s means inequality are quite low and illustrates quite well the installation program. Sub focus on the process of implementing the program generates a Skor value of ten, it’s means that inequality is high enough and illustrates that the process of program implementation should be improved both from the aspect of organization, management of human resources and services. Sub focus of product produces a value of ten, it’s means that high inequality. This illustrates that the product of service complaints and dispute mediation and child rights violations in KPAI, in need of repair and upgrading. This study found some substantial weaknesses in the implementation of the program by KPAI. Limited human resources, organizational structure ineffective, limited information service system, the absence of a quality management system in service and availability of facilities, infrastructure and facilities that have not been friendly for users of the service. This is a major problem that must be corrected to improve the quality of public complaints service program of and mediation of dispute child rights violations in KPAI.

APS power supply controls

International Nuclear Information System (INIS)

Saunders, C.W.; Despe, O.D.

1994-01-01

The purpose of this document is to provide comprehensive coverage of the APS power supply control design. This includes application software, embedded controller software, networks, and hardware. The basic components will be introduced first, followed by the requirements driving the overall design. Subsequent sections will address each component of the design one by one. Latter sections will address specific applications

Comportamento da eosinofilia após o tratamento das geohelmintoses

Directory of Open Access Journals (Sweden)

Marta Maria Bozóti

1973-04-01

Full Text Available A eosinofilia sanguínea após o tratamento anti-helmíntico específico se comportou numa amostragem de 57 crianças da seguinte forma: .Na ascaridíase isolada ou associada à trieuríase a hipereosinofilia parasitária ou descia uniformemente após o tratamento, ou houve primeiro uma exacerbação que durava até a terceira semana após a erradicação da, parasitose, descendo em seguida. Em ambos os casos houve normalização do hemograma em dois meses. Na associação ascaridíase/ancilostomíase também são possíveis dois tipos de comportamento da eosinofilia após tratamento eficaz: ou vai diminuindo a hipereosinofilia, logo em seguida à expulsão dos parasitos, ou há no primeiro mês um aumento da hipereosinofilia (geralmente mais acentuado na primeira semana que se segue ao tratamento, para diminuir após o fim do primeiro mês progressivamente até desaparecer. Na estrongiloidíase e na associação ascaridíase/estrongiloidíase há diminuição constante da hipereosinofilia logo após o tratamento e o hemograma se normaliza em cerca de dois meses. Na trieuríase, a hipereosinofilia, aliás já discreta, diminui pouco com o tratamento. Na ancilostomíase e na associação ancilostomíase/trieuríase a hipereosinofilia ou desce após o tratamento gradativo e lentamente, ou primeiro há uma exaltação temporária nas primeiras três semanas após a terapêutica, para diminuir em seguida. Na associação ancilostomíase/estrongiloidíase também se encontram esses dois tipos de comportamento da hipereosinofilia verminótica, mas a exacerbação da hipereosinofilia, que ocorre na metade dos casos, só dura duas semanas; a regressão eosinofílica ocorre dois meses após o tratamento. Nas tri e tetraeparasitoses a involução pós-terapêutica da hipereosinofilia é irregular e a normalização das taxas sanguíneas de eosinófilos é sempre arrastada, principalmente nas associações ascaridíase/estrongiloidíase/ancilostomíase e

APS - Diagnostics and challenges for the future.

Science.gov (United States)

Pengo, V; Bison, E; Zoppellaro, G; Padayattil Jose, S; Denas, G; Hoxha, A; Ruffatti, A; Banzato, A

2016-11-01

Diagnosis of antiphospholipid syndrome (APS) is essentially based on the detection of circulating antiphospholipid (aPL) antibodies. Progress have been made on the standardization of tests exploring the presence of aPL as guidelines on coagulation and immunological tests were recently published in the literature. Clinical relevance of aPL profile has come from prospective cohort studies in populations with a homogeneous antibody profile supporting the view that triple positivity is a high risk pattern in patients and carriers. In addition to the classic ones, several other tests have been proposed for the diagnosis of APS. The detection of antibodies directed to domain 1 and 4/5 of β2-Glycoprotein I (β2GP1) were found to be particularly sound. Several issues remain to be addressed. We do not yet know what is the physiological function of β2GP1 and the pathophysiology of thrombosis and pregnancy loss in these patients. Moreover, treatment is poorly defined especially in the case of feared catastrophic APS. Copyright © 2016 Elsevier B.V. All rights reserved.

Anti-phosphatidylserine/prothrombin antibodies: an additional diagnostic marker for APS?

Science.gov (United States)

Pregnolato, Francesca; Chighizola, Cecilia B; Encabo, Susan; Shums, Zakera; Norman, Gary L; Tripodi, Armando; Chantarangkul, Veena; Bertero, Tiziana; De Micheli, Valeria; Borghi, Maria Orietta; Meroni, Pier Luigi

2013-07-01

Among the diagnostic assays for anti-phospholipid syndrome (APS), lupus anticoagulant (LA) is the strongest predictor of thrombosis; however, it presents several limitations as interference with anticoagulant therapy and poor inter-laboratory agreement. Two-thirds of LA activity is apparently due to antibodies against prothrombin (PT), usually detectable by ELISA. Binding of PT to phosphatidylserine (PS) has been shown to enhance solid-phase anti-PT assay sensitivity. To determine the prevalence of antibodies against PS/PT (aPS/PT) in APS, we tested the semiquantitative QUANTA Lite(®) aPS/PT ELISA in a cohort of 80 APS patients. The prevalence of aPS/PT was 81.3%, rising to 87.6% when considering LA-positive subjects only. We observed a strong correlation between aPS/PT and LA (p = 0.006). To note, APS patients with thrombotic manifestations displayed significantly higher IgG aPS/PT titers compared to 20 aPL asymptomatic carriers (p = 0.012). To rule out a possible cross-reactivity of anti-β2 glycoprotein I antibodies (aβ2GPI) with PS/PT complex, we tested two monoclonal aβ2GPI antibodies and an affinity-purified (AP) polyclonal aβ2GPI IgG obtained from the serum of a patient reacting against both β2GPI and PS/PT. The two monoclonal antibodies did not show any reactivity against PS/PT complex, similarly the AP IgGs did not react toward PS/PT antigen while preserved their aβ2GPI activity. Our findings suggest that aPS/PT are a definite antibody population in APS. Moreover, the good correlation between aPS/PT ELISA and LA may support its use as a surrogate test for LA, particularly useful to overcome the technical limitations of the functional assay.

Molecular Basis for Enhancement of the Meiotic DMCI Recombinase by RAD51AP1

Energy Technology Data Exchange (ETDEWEB)

Dray, Eloise; Dunlop, Myun Hwa; Kauppi, Liisa; San Filippo, Joseph San; Wiese, Claudia; Tsai, Miaw-Sheue; Begovic, Sead; Schild, David; Jasin, Maria; Keeney, Scott; Sung, Patrick

2010-11-05

Homologous recombination is needed for meiotic chromosome segregation, genome maintenance, and tumor suppression. RAD51AP1 (RAD51 Associated Protein 1) has been shown to interact with and enhance the recombinase activity of RAD51. Accordingly, genetic ablation of RAD51AP1 leads to enhanced sensitivity to and also chromosome aberrations upon DNA damage, demonstrating a role for RAD51AP1 in mitotic homologous recombination. Here we show physical association of RAD51AP1 with the meiosis-specific recombinase DMC1 and a stimulatory effect of RAD51AP1 on the DMC1-mediated D-loop reaction. Mechanistic studies have revealed that RAD51AP1 enhances the ability of the DMC1 presynaptic filament to capture the duplex DNA partner and to assemble the synaptic complex, in which the recombining DNA strands are homologously aligned. We also provide evidence that functional co-operation is dependent on complex formation between DMC1 and RAD51AP1, and that distinct epitopes in RAD51AP1 mediate interactions with RAD51 and DMC1. Finally, we show that RAD51AP1 is expressed in mouse testes, and that RAD51AP1 foci co-localize with a subset of DMC1 foci in spermatocytes. These results suggest that RAD51AP1 also serves an important role in meiotic homologous recombination.

Incorporation of Socio-Economic Features' Ranking in Multicriteria Analysis Based on Ecosystem Services for Marine Protected Area Planning.

Directory of Open Access Journals (Sweden)

Michelle E Portman

Full Text Available Developed decades ago for spatial choice problems related to zoning in the urban planning field, multicriteria analysis (MCA has more recently been applied to environmental conflicts and presented in several documented cases for the creation of protected area management plans. Its application is considered here for the development of zoning as part of a proposed marine protected area management plan. The case study incorporates specially-explicit conservation features while considering stakeholder preferences, expert opinion and characteristics of data quality. It involves the weighting of criteria using a modified analytical hierarchy process. Experts ranked physical attributes which include socio-economically valued physical features. The parameters used for the ranking of (physical attributes important for socio-economic reasons are derived from the field of ecosystem services assessment. Inclusion of these feature values results in protection that emphasizes those areas closest to shore, most likely because of accessibility and familiarity parameters and because of data biases. Therefore, other spatial conservation prioritization methods should be considered to supplement the MCA and efforts should be made to improve data about ecosystem service values farther from shore. Otherwise, the MCA method allows incorporation of expert and stakeholder preferences and ecosystem services values while maintaining the advantages of simplicity and clarity.

The dyad palindromic glutathione transferase P enhancer binds multiple factors including AP1.

Science.gov (United States)

Diccianni, M B; Imagawa, M; Muramatsu, M

1992-10-11

Glutathione Transferase P (GST-P) gene expression is dominantly regulated by an upstream enhancer (GPEI) consisting of a dyad of palindromically oriented imperfect TPA (12-O-tetradecanoyl-phorbol-13-acetate)-responsive elements (TRE). GPEI is active in AP1-lacking F9 cells as well in AP1-containing HeLa cells. Despite GPEI's similarity to a TRE, c-jun co-transfection has only a minimal effect on transactivation. Antisense c-jun and c-fos co-transfection experiments further demonstrate the lack of a role for AP1 in GPEI mediated trans-activation in F9 cells, although endogenously present AP1 can influence GPEI in HeLa cells. Co-transfection of delta fosB with c-jun, which forms an inactive c-Jun/delta FosB heterodimer that binds TRE sequences, inhibits GPEI-mediated transcription in AP1-lacking F9 cells as well as AP1-containing HeLa cells. These data suggest novel factor(s) other than AP1 are influencing GPEI. Binding studies reveal multiple nucleoproteins bind to GPEI. These factors are likely responsible for the high level of GPEI-mediated transcription observed in the absence of AP1 and during hepatocarcinogenesis.

Discussion of QA grading for AP1000 NP plant

International Nuclear Information System (INIS)

Luo Shuiyun; Zhang Qingchuan

2012-01-01

The grading method of quality assurance for the following AP1000 project is presented based on the Westinghouse classification principle, referring to the classification method of the AP1000 self-reliance supporting project and considering the factors of classification, which can meet the requirements of domestic nuclear safety regulation and standard of the QA classification. (authors)

Status of the Advanced Photon Source (APS) linear accelerator

International Nuclear Information System (INIS)

White, M.; Berg, W.; Fuja, R.; Grelick, A.; Mavrogenes, G.; Nassiri, A.; Russell, T.; Wesolowski, W.

1993-01-01

A 2856-MHz S-band, 450-MeV electron/positron linear accelerator is the first part of the injector for the Advanced Photon Source (APS) 7-GeV storage ring. Construction of the APS linac is currently nearing completion, and commissioning will begin in July 1993. The linac and its current status are discussed in this paper

Difference of reactor core nuclear instrument between AP1000 and CPR1000

International Nuclear Information System (INIS)

Zhang Shidong; Zhou Can; Deng Tian

2014-01-01

As a typical generation Ⅲ reactor technique, the AP1000 applies many advanced design concepts, simplifies the design, reduces equipment quantities, and thus enhances systematic reliability. The comparison of reactor core measurement instrument differences between AP1000 and CPR1000 from several aspects was involved in the paper. Through analysis and comparison of these differences, passive design concepts and characteristics of AP1000 are familiarized, and conveniences for staffs engaged in CPR1000 to learn and grasp AP1000 technique are provided. It is useful in reactor start up, operation and maintenance. (authors)

Modeling Instruction in AP Physics C: Mechanics and Electricity and Magnetism

Science.gov (United States)

Belcher, Nathan Tillman

This action research study used data from multiple assessments in Mechanics and Electricity and Magnetism to determine the viability of Modeling Instruction as a pedagogy for students in AP Physics C: Mechanics and Electricity and Magnetism. Modeling Instruction is a guided-inquiry approach to teaching science in which students progress through the Modeling Cycle to develop a fully-constructed model for a scientific concept. AP Physics C: Mechanics and Electricity and Magnetism are calculus-based physics courses, approximately equivalent to first-year calculus-based physics courses at the collegiate level. Using a one-group pretest-posttest design, students were assessed in Mechanics using the Force Concept Inventory, Mechanics Baseline Test, and 2015 AP Physics C: Mechanics Practice Exam. With the same design, students were assessed in Electricity and Magnetism on the Brief Electricity and Magnetism Assessment, Electricity and Magnetism Conceptual Assessment, and 2015 AP Physics C: Electricity and Magnetism Practice Exam. In a one-shot case study design, student scores were collected from the 2017 AP Physics C: Mechanics and Electricity and Magnetism Exams. Students performed moderately well on the assessments in Mechanics and Electricity and Magnetism, demonstrating that Modeling Instruction is a viable pedagogy in AP Physics C: Electricity and Magnetism.

The Role of the Clathrin Adaptor AP-1: Polarized Sorting and Beyond

Directory of Open Access Journals (Sweden)

Fubito Nakatsu

2014-11-01

Full Text Available The selective transport of proteins or lipids by vesicular transport is a fundamental process supporting cellular physiology. The budding process involves cargo sorting and vesicle formation at the donor membrane and constitutes an important process in vesicular transport. This process is particularly important for the polarized sorting in epithelial cells, in which the cargo molecules need to be selectively sorted and transported to two distinct destinations, the apical or basolateral plasma membrane. Adaptor protein (AP-1, a member of the AP complex family, which includes the ubiquitously expressed AP-1A and the epithelium-specific AP-1B, regulates polarized sorting at the trans-Golgi network and/or at the recycling endosomes. A growing body of evidence, especially from studies using model organisms and animals, demonstrates that the AP-1-mediated polarized sorting supports the development and physiology of multi-cellular units as functional organs and tissues (e.g., cell fate determination, inflammation and gut immune homeostasis. Furthermore, a possible involvement of AP-1B in the pathogenesis of human diseases, such as Crohn’s disease and cancer, is now becoming evident. These data highlight the significant contribution of AP-1 complexes to the physiology of multicellular organisms, as master regulators of polarized sorting in epithelial cells.

A Novel Protective Framework for Defeating HTTP-Based Denial of Service and Distributed Denial of Service Attacks

Directory of Open Access Journals (Sweden)

Mohammed A. Saleh

2015-01-01

Full Text Available The growth of web technology has brought convenience to our life, since it has become the most important communication channel. However, now this merit is threatened by complicated network-based attacks, such as denial of service (DoS and distributed denial of service (DDoS attacks. Despite many researchers’ efforts, no optimal solution that addresses all sorts of HTTP DoS/DDoS attacks is on offer. Therefore, this research aims to fix this gap by designing an alternative solution called a flexible, collaborative, multilayer, DDoS prevention framework (FCMDPF. The innovative design of the FCMDPF framework handles all aspects of HTTP-based DoS/DDoS attacks through the following three subsequent framework’s schemes (layers. Firstly, an outer blocking (OB scheme blocks attacking IP source if it is listed on the black list table. Secondly, the service traceback oriented architecture (STBOA scheme is to validate whether the incoming request is launched by a human or by an automated tool. Then, it traces back the true attacking IP source. Thirdly, the flexible advanced entropy based (FAEB scheme is to eliminate high rate DDoS (HR-DDoS and flash crowd (FC attacks. Compared to the previous researches, our framework’s design provides an efficient protection for web applications against all sorts of DoS/DDoS attacks.

The applies specific technical requirements to the services of radiological protection according to the 17025

Energy Technology Data Exchange (ETDEWEB)

Marrero Garcia, M.; Fernandez Gomez, I. M.; Prendes Alonso, M.; Molina Perez, D.

2004-07-01

The employment in the Center of Radiation Protection and Hygiene (CRPH) of Cuba, of the standard 17025 for the administration of the quality of the calibration laboratories and test that offer services of radiological protection requires of a technical complement to really determine the technical competence. In the standard 17025, the specific requirements, are mentioned in the annex B (with informative character), where it points out that: {sup T}he requirements specified in the standard 17025 are established in general terms and, although they can be applied to all the test laboratories and applications, they could be necessary applications{sup .} In the CRPH these applications are translated in indispensable technical requirements to evaluate the performance of the services of radiological protection that offers, specifically those of personal monitoring, the calibration of instruments and the metrology of radionuclides. Although the standard 17025 is quite rigorous in the evaluation of technical requirements, to have specific materials not serves alone of tool to the laboratories, but also for the body of accreditation . In the CRPH the permanent employment of this tool has not constituted a practice, but had been good before our clients certain nonconformities to evaluate the performance of the laboratory and to achieve the recovery of the trust in its results. With this work we seek to expose some of these experiences. The experiences of the application of some of the technical requirements, in our case, they have been applied to the service of personal monitoring that offers the Laboratory of Personal Dosimetry. This laboratory is accredited by the National Accreditation Board of the Republic of Cuba (NABC) and besides fulfilling that settled down in 17025, the Approaches of Accreditation for test laboratories and calibration and it should also implant that settled down as specific technical requirements for the recognition of technical competence. (Author

Principles of Radiation Protection Concepts

International Nuclear Information System (INIS)

Abd Aziz Mhd Ramli

2004-01-01

The contents of this chapter are follows - Radiation Protection Concepts: justification, dose limitation, optimisation, potential exposures, situation requiring intervention; Special Considerations. Protection from Radiation Hazards, Remove the Hazard, Prevent the Hazard, Guard the Worker, Implementation of Radiation Protection and Safety Measures, Distance, Shielding, Time, Monitoring Programme, Safety System. Radiation Protection in Radiological Service: Specific Requirement in Diagnostic Radiological Service

AP-102/104 Retrieval control system qualification test procedure

International Nuclear Information System (INIS)

RIECK, C.A.

1999-01-01

This Qualification Test Procedure documents the results of the qualification testing that was performed on the Project W-211, ''Initial Tank Retrieval Systems,'' retrieval control system (RCS) for tanks 241-AP-102 and 241-AP-104. The results confirm that the RCS has been programmed correctly and that the two related hardware enclosures have been assembled in accordance with the design documents

Extending Service Area of IEEE 802.11 Ad Hoc Networks

Science.gov (United States)

Choi, Woo-Yong

2012-06-01

According to the current IEEE 802.11 wireless LAN standards, IEEE 802.11 ad hoc networks have the limitation that all STAs (Stations) are in the one-hop transmission range of each other. In this paper, to alleviate the limitation of IEEE 802.11 ad hoc networks we propose the efficient method for selecting the most appropriate pseudo AP (Access Point) from among the set of ad hoc STAs and extending the service area of IEEE 802.11 ad hoc networks by the pseudo AP's relaying the internal traffic of IEEE 802.11 ad hoc networks. Numerical examples show that the proposed method significantly extends the service area of IEEE 802.11 ad hoc networks.

The immunobiology and clinical features of type 1 autoimmune polyglandular syndrome (APS-1).

Science.gov (United States)

Guo, Can-Jie; Leung, Patrick S C; Zhang, Weici; Ma, Xiong; Gershwin, M Eric

2018-01-01

Autoimmune Polyglandular Syndrome type 1 (APS-1) is a subtype of the autoimmune polyendocrine syndrome characterized by the simultaneous or sequential dysfunction of multiple endocrine or non-endocrine glands. A clinical diagnosis of APS-1 is typically based on the presence of at least two of three following criteria: chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal insufficiency. The first identified causative mutated gene for APS-1 is autoimmune regulator (AIRE) encoding a critical transcription factor, which is primarily expressed in the medullary thymic epithelial cells (mTECs) for generating central immune tolerance. A wide range of chronic, debilitating complications, with no obvious correlation with genetics, makes a diagnosis of APS-1 challenging early in the disease course. Managing APS-1 is difficult due to its complexity, especially the intricate relationships within manifestations and genetic mutations. The past decades have witnessed dramatic progress in elucidating the function of AIRE and conducting large-scale cohort studies in APS-1. However, no clear evidence-based guidelines have been established in APS-1. In this review, we provide a detailed critical overview of the study history, epidemiology, clinical features, and related mechanisms of autoimmunity in APS-1, as well as currently available therapies for this autoimmune disorder. Copyright © 2017 Elsevier B.V. All rights reserved.

AP600 level of automation: United States utility perspective

International Nuclear Information System (INIS)

Bekkerman, A.Y.

1997-01-01

Design of the AP600 advanced nuclear plant man-machine interface system (M-MIS) is guided by the applicable requirements from the Utility Requirements Document (URD). However, the URD has left certain aspects of the M-MIS to be determined by the designer working together with utilities sponsoring the work. This is particularly true in the case of the level of automation to be designed into the M-MIS. Based on experience from currently operating plants, utilities have specified the identity and roles of personnel in the control room, which has led to establishing a number of level of automation issues for the AP600. The key role of automated computerized procedures in the AP600 automation has been determined and resolved. 5 refs

JACoW Versatile service for the protection of experimental areas at CERN

CERN Document Server

Valentini, Francesco; Ninin, Pierre

2018-01-01

CERN hosts a number of other experimental areas with a rich research program ranging from fundamental physics to medical applications. The risk assessments have shown a large palette of potential hazards (radiological, electrical, chemical, laser, etc.) that need to be properly mitigated in order to ensure the safety of personnel working inside these areas. A Personnel Protection System, typically, accomplishes this goal by implementing a certain number of heterogeneous functionalities as interlocks of critical elements, management of a local HMI, data monitoring and interfacing with RFID badge readers. Given those requirements, reducing system complexity and costs are key parameters to be optimized in the solution. This paper is aimed at summarizing the findings, in terms of costs, complexity and maintenance reduction, offered by a technology from National Instruments® based on cRIO controllers and a new series of SIL-3 certified safety I/O modules. A use case based on a service for the protection of Class ...

Sherwood/APS 2006 Conference. Final report

International Nuclear Information System (INIS)

Drake, James F.

2009-01-01

The International Sherwood Theory Meeting is a yearly meeting that focuses on the theory of magnetically confined fusion plasmas. There are many topics of common interest in fusion plasma systems and space and astrophysical plasmas. These common topics include such key topics as magnetic reconnection, the dynamo, turbulence and transport and particle heating and acceleration. One of the major participants of the April APS meeting is the APS Division of Astrophysics (DAP). The goal of having the Sherwood Meeting jointly with the April meeting was to promote discussion of topics of common interest in fusion and space and astrophysics. Scientists from the DAP, the Division of Plasma Physics (DPP), the Topical Group on Plasma Astrophysics (GPAP) and Sherwood worked together closely to produce a joint program that addressed areas of common interest. Four sessions of invited talks were sponsored jointly by the DAP, DPP and GPAP on laboratory experiments related to astrophysics. Plasma scientists working in theory and computation play a key role in connecting these laboratory experiments to the very disparate conditions found in fusion and astrophysical systems. Thus, the attendees of the Sherwood Theory meeting were critical to facilitating this effort at cross-disciplinary communication. Noteworthy were the selection of two of the prestigious plenary talks at the joint meeting on plasma topics - one related to the gyrokinetic modeling of turbulence and the other related to the structure of collisionless shocks. It is rare to see even a single plenary talk on plasma physics at the APS April Meeting. There were additional costs associated with hosting a joint meeting. The Office of Fusion Energy Sciences contributed $3000 in partial support of this meeting. This funding covered part of the costs of the poster boards and A. V. equipment that was used in the presentation of nearly 200 scientific papers related to magnetically confined fusion plasmas. The APS waived its

Obstetric and vascular APS: same autoantibodies but different diseases?

Science.gov (United States)

Meroni, P L; Raschi, E; Grossi, C; Pregnolato, F; Trespidi, L; Acaia, B; Borghi, M O

2012-06-01

Beta2 glycoprotein I (β2GPI)-dependent antiphospholipid antibodies (aPLs) are the main pathogenic autoantibody population and at the same time the laboratory diagnostic tool for the antiphospholipid syndrome (APS). These antibodies are responsible for both the vascular and the obstetric manifestations of the syndrome but the pathogenic mechanisms behind these manifestations are not the same. For example, thrombotic events do not appear to play a major role in APS miscarriages and a direct reactivity of β2GPI-dependent aPLs on decidual and trophoblast cells was reported. A local expression of β2GPI on these tissues was reported both in physiological conditions and in APS women, thus explaining the local tropism of the autoantibodies. The two hit hypothesis was suggested to explain why the vascular manifestations of APS may occur only occasionally in spite of the persistent presence of aPLs. This is not apparently the case for the obstetric variant of the syndrome, making the difference even more striking. A different pathogenesis may also provide the rationale for the well-known fact that the vascular and the obstetric manifestations may occur independently although in a minority of cases.

Functional interaction between the glucocorticoid receptor and GANP/MCM3AP

International Nuclear Information System (INIS)

Osman, Waffa; Laine, Sanna; Zilliacus, Johanna

2006-01-01

Glucocorticoids are widely used to treat inflammatory diseases but have a number of side effects that partly are connected to inhibition of cell proliferation. Glucocorticoids mediated their action by binding to the glucocorticoid receptor. In the present study, we have identified by two-hybrid screens the germinal center-associated protein (GANP) and MCM3-associated protein (MCM3AP), a splicing variant of GANP, as glucocorticoid receptor interacting proteins. GANP and MCM3AP can bind to the MCM3 protein involved in initiation of DNA replication. Glutathione-S-transferase-pull-down and co-immunoprecipitation assays showed that the C-terminal domain of GANP, encompassing MCM3AP, interacts with the ligand-binding domain of the glucocorticoid receptor. Characterization of the intracellular localization of GANP revealed that GANP is shuttling between the nucleus and the cytoplasm. Furthermore, we show that glucocorticoids are unable to inhibit DNA replication in HeLa cells overexpressing MCM3AP suggesting a role for both glucocorticoid receptor and GANP/MCM3AP in regulating cell proliferation

X-ray optics simulation and beamline design for the APS upgrade

Science.gov (United States)

Shi, Xianbo; Reininger, Ruben; Harder, Ross; Haeffner, Dean

2017-08-01

The upgrade of the Advanced Photon Source (APS) to a Multi-Bend Achromat (MBA) will increase the brightness of the APS by between two and three orders of magnitude. The APS upgrade (APS-U) project includes a list of feature beamlines that will take full advantage of the new machine. Many of the existing beamlines will be also upgraded to profit from this significant machine enhancement. Optics simulations are essential in the design and optimization of these new and existing beamlines. In this contribution, the simulation tools used and developed at APS, ranging from analytical to numerical methods, are summarized. Three general optical layouts are compared in terms of their coherence control and focusing capabilities. The concept of zoom optics, where two sets of focusing elements (e.g., CRLs and KB mirrors) are used to provide variable beam sizes at a fixed focal plane, is optimized analytically. The effects of figure errors on the vertical spot size and on the local coherence along the vertical direction of the optimized design are investigated.

Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice.

Science.gov (United States)

Hwang, S-K; Jin, H; Kwon, J T; Chang, S-H; Kim, T H; Cho, C-S; Lee, K H; Young, M R; Colburn, N H; Beck, G R; Yang, H-S; Cho, M-H

2007-09-01

The long-term survival of lung cancer patients treated with conventional therapies remains poor and therefore the need for novel approaches remains high. This has led to the re-emergence of aerosol delivery as a therapeutic intervention. In this study, glucosylated polyethylenimine (GPEI) was used as carrier to investigate programmed cell death 4 (PDCD4) and PDCD4 mutant (D418A), an eIF4A-binding mutant, on PDCD4-related signaling and activator protein-1 (AP-1) activity in the lungs of AP-1 luciferase reporter mice. After confirming the efficiency of GPEI as a carrier in lungs, the effects of aerosol-delivered PDCD4 were investigated in AP-1 luciferase reporter mice. Aerosol delivery of GPEI/PDCD4 through a nose-only inhalation facilitated the apoptosis of lungs whereas aerosol PDCD4 mutant did not. Also, such aerosol delivery regulated proteins relevant to cell-cycle control and suppressed AP-1 activity. Results obtained by western blot analysis, immunohistochemistry, luciferase assay and deoxynucleotidyl-transferase-mediated nick end labeling study suggest that combined actions such as facilitating apoptosis, controlling cell cycle and suppression of AP-1 activity by PDCD4 may provide useful tool for designing lung tumor prevention and treatment by which PDCD4 functions as a transformation suppressor in the future.

Finite element modeling of AP1000 nuclear island

International Nuclear Information System (INIS)

Tinic, S.; Orr, R.

2003-01-01

The AP1000 is a standard design developed by Westinghouse and its partners for an advanced nuclear power plant utilizing passive safety features. It is based on the certified design of the AP600 and has been uprated to 1000 MWe. The plant has five principal building structures; the nuclear island, the turbine building; the annex building; the diesel generator building and the radwaste building. The nuclear island consists of the containment building (the steel containment vessel and the containment internal structures), the shield building, and the auxiliary building. These structures are founded on a common basemat and are collectively known as the nuclear island. This paper describes use of the general purpose finite element program ANSYS [2] in structural analyses and qualification of the AP1000 nuclear island buildings. It describes the modeling of the shield building and the auxiliary building and the series of analyses and the flow of information from the global analyses to the detailed analyses and building qualification. (author)

APS-U LATTICE DESIGN FOR OFF-AXIS ACCUMULATION

Energy Technology Data Exchange (ETDEWEB)

Sun, Yipeng; Borland, M.; Lindberg, R.; Sajaev, V.

2017-06-25

A 67-pm hybrid-seven-bend achromat (H7BA) lattice is being proposed for a future Advanced Photon Source (APS) multi-bend-achromat (MBA) upgrade project. This lattice design pushes for smaller emittance and requires use of a swap-out (on-axis) injection scheme due to limited dynamic acceptance. Alternate lattice design work has also been performed for the APS upgrade to achieve better beam dynamics performance than the nominal APS MBA lattice, in order to allow off-axis accumulation. Two such alternate H7BA lattice designs, which target a still-low emittance of 90 pm, are discussed in detail in this paper. Although the single-particle-dynamics performance is good, simulations of collective effects indicate that surprising difficulty would be expected accumulating high single-bunch charge in this lattice. The brightness of the 90-pm lattice is also a factor of two lower than the 67-pm H7BA lattice.

Tawny owl (Strix aluco) as a potential transmitter of Enterobacteriaceae epidemiologically relevant for forest service workers, nature protection service and ornithologists.

Science.gov (United States)

Grzywaczewski, Grzegorz; Kowalczyk-Pecka, Danuta; Cios, Szymon; Bojar, Wiktor; Jankuszew, Andrzej; Bojar, Hubert; Kolejko, Marcin

2017-03-31

Established taxa within the Enterobacteriaceae wereisolated from cloacal swabs of Strix aluco chicks in nest boxes located at five research sites. ChromID ESBL medium (bioMerieux) was used to select a pool of Enterobacteriaceae strains producing extended-spectrum beta-lactamases. Drug sensitivity of the chosen strains was determined from the full pool of Enterobacteriaceae to 6 chemotherapeutics of different mechanisms of action. The study evaluated the sensitivity of ESBL-synthesizing isolates to substances belonging to penicillins, cephalosporins, cephamycins, clavams, carbapenems and monobactams. Analysis of the results indicated a potential role of Strix aluco in the dissemination of epidemiologically-relevant Enterobacteriaceae, and, importantly, pose health risks to forest service workers, nature protection service and ornithologists. The results can also serve as the basis for further environmental studies.

The interaction between the adaptor protein APS and Enigma is involved in actin organisation

DEFF Research Database (Denmark)

Barres, Romain; Gonzalez, Teresa; Le Marchand-Brustel, Yannick

2005-01-01

that was previously shown to be associated with the actin cytoskeleton. In HEK 293 cells, Enigma interacted specifically with APS, but not with the APS-related protein SH2-B. This interaction required the NPTY motif of APS and the LIM domains of Enigma. In NIH-3T3 cells that express the insulin receptor, Enigma...... cytoskeleton organisation, expression of Enigma alone led to the formation of F-actin clusters. Similar alteration in actin cytoskeleton organisation was observed in cells expressing both Enigma and APS with a mutation in the NPTY motif. These results identify Enigma as a novel APS-binding protein and suggest...... that the APS/Enigma complex plays a critical role in actin cytoskeleton organisation....

Loss-of-normal-feedwater sensitivity studies for AP600 behavior characterization

International Nuclear Information System (INIS)

Saiu, G.

1996-01-01

Activity concerning the development of a RELAP5/MOD3 model to simulate the Westinghouse Electric Corporation AP600 is summarized. The aim is to gain initial insight into the capability of RELAP5 to simulate the behavior of AP600 safety features. A-loss-of-normal-feedwater event is studied. Of the transients that must be investigated, this transient has been chosen to be one of the most relevant because the response of the AP600 to a loss-of-normal-feedwater event differs significantly from that of current pressurized water reactors in the extensive use of passive safety features peculiar to the AP600. Also, strong interactions among the AP600 safety systems, which should be further analyzed to permit full optimization of the system actuation logic and operation, are shown. Finally, a loss of normal feedwater without reactor scram, performed to investigate short-term plant behavior, shows that the pressure peak is affected by critical discharge flow coefficients applied to the pressurizer safety valves, while a relatively small reduction of the pressure peak is observed when both heat exchangers of the passive heat removal system are operating as opposed to the case in which only one is available. The data used for this study are derived from the Standard Safety Analysis Report configuration of the Westinghouse AP600 as of 1992

An analysis of AP600 design features

International Nuclear Information System (INIS)

Park, Jong Kyoon; Jang, Moon Heui; Hwang, Yung Dong

1994-01-01

In the aspect of engineering, passive safety system concept has improved the safety degree of nuclear power plant. Therefore, the objective of this study is to check on the possibility of the capacity upgrade of nuclear power plant in the case of adopting the passive safety system concept of AP 600. The characteristics of AP 600 are the advanced functions in ECCS, heat removal of containment building and residual heat removal under the passive safety system concept. The result of this study will become the basic data of capacity upgrade of nuclear power plant and will be widely used in second year project. (Author)

An analysis of AP600 design features

Energy Technology Data Exchange (ETDEWEB)

Park, Jong Kyoon; Jang, Moon Heui; Hwang, Yung Dong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); and others

1994-01-01

In the aspect of engineering, passive safety system concept has improved the safety degree of nuclear power plant. Therefore, the objective of this study is to check on the possibility of the capacity upgrade of nuclear power plant in the case of adopting the passive safety system concept of AP 600. The characteristics of AP 600 are the advanced functions in ECCS, heat removal of containment building and residual heat removal under the passive safety system concept. The result of this study will become the basic data of capacity upgrade of nuclear power plant and will be widely used in second year project. (Author).

Organized and Unstructured Activity Participation among Adolescents Involved with Child Protective Services in the United States

Science.gov (United States)

Kwak, Yoonyoung; Lu, Ting; Christ, Sharon L.

2017-01-01

Background: Many adolescents are referred to Child Protective Services for possible maltreatment every year, but not much is known about their organized and unstructured activity participation. Objective: The purposes of this study are to provide a description of organized and unstructured activity participation for adolescents who were possible…

Health in All Policies (HiAP) governance: lessons from network governance.

Science.gov (United States)

Khayatzadeh-Mahani, Akram; Ruckert, Arne; Labonté, Ronald; Kenis, Patrick; Akbari-Javar, Mohammad Reza

2018-05-25

The Health in All Policies (HiAP) approach requires formal and sustained governance structures and mechanisms to ensure that the policies of various non-health sectors maximize positive and minimize negative impacts on population health. In this paper, we demonstrate the usefulness of a network perspective in understanding and contributing to the effectiveness of HiAP. We undertook an exploratory, qualitative case study of a HiAP structure in Iran, the Kerman province Council of Health and Food Security (CHFS) with diverse members from health and non-health sectors. We analyzed relevant policy texts and interviewed 32 policy actors involved in the CHFS. Data were analyzed using within-case analysis and constant comparative methodology. Our findings suggest that CHFS governance from a network perspective drew in practice on elements of two competing network governance modes: the network administrative organization (NAO) and the lead organization mode. Our results also show that a shift from a hierarchical and market-based mode of interaction to a network logic within CHFS has not yet taken place. In addition, CHFS suffers from large membership and an inability to address complex 'wicked problems', as well as low trust, legitimacy and goal consensus among its members. Drawing on other HiAP studies and commentaries, insights from organization network theory, and in-depth findings from our case study, we conclude that a NAO may be the most effective mode of governance for tackling complex social problems in HiAP structures. Since similar studies are limited, and our single case study may not be transferable across all contexts, we suggest that further research be undertaken to explore HiAP structures from a network perspective in different institutional and cultural settings. With increasing emphasis given to HiAP approaches in national and international health policy discourse, it is important that comparative knowledge about the effectiveness of HiAP governance

HSE management for AP1000 nuclear plant construction in EPC mode

International Nuclear Information System (INIS)

He Xiaogang; Wei Zhong

2010-01-01

As a new nuclear type, AP1000 will become the development direction of Chinese nuclear project. EPC General Contract mode is favored by nuclear owners both at home and abroad. Therefore, there is necessity for studying HSE management system and method suitable for AP1000 nuclear plant construction (ANPC) based on combination of AP1000 construction characters in EPC mode. This can not only ensure safety for ANPC but also positively promote national nuclear power development. For this reason, based on site HSE management of the first AP1000 nuclear plant under construction, HSE management system and method for ANPC in EPC mode was proposed after analysis of the character of EPC mode and ANPC character. It is hoped that it will be helpful for safe construction for ANPC. (authors)

Containment integrity analysis for the (W) advanced AP600

International Nuclear Information System (INIS)

Gagnon, A.F.; Howe, K.S.

1989-01-01

This paper reports that since 1987, Westinghouse has been performing containment cooling analyses in support of the Advanced AP600 plant design. This program was intended to verify the feasibility of the passive containment cooling system features of the AP600 design. To support this design, containment analyses of the AP600 containment for a large break LOCA and a large Steam Line Break were performed. The transient results indicate the feasibility of the passive containment design by demonstrating the capability to remove sufficient heat to limit containment atmosphere conditions to within acceptable limits following these postulated accidents. These results also indicate that the PCCS can reduce containment pressure to less than one-quarter design pressure at 24 hours following the most severe accident scenario thereby minimizing containment leakage concerns

A New Photometric Study of Ap and Am Stars in the Infrared

Energy Technology Data Exchange (ETDEWEB)

Chen, P. S.; Liu, J. Y.; Shan, H. G., E-mail: chenps@ynao.ac.cn [Yunnan Observatories and Key Laboratory for the Structure and Evolution of Celestial Objects, Chinese Academy of Sciences, Kunming 650011 (China)

2017-05-01

In this paper, 426 well known confirmed Ap and Am stars are photometrically studied in the infrared. The 2MASS, Wide-field Infrared Survey Explorer ( WISE ), and IRAS data are employed to make analyses. The results in this paper have shown that in the 1–3 μ m region over 90% Ap and Am stars have no or little infrared excesses, and infrared radiations in the near-infrared from these stars are probably dominated by the free–free emissions. It is also shown that in the 3–12 μ m region, the majority of Ap stars and Am stars have very similar behavior, i.e., in the W 1– W 2 (3.4–4.6 μ m) region, over half of Ap and Am stars have clear infrared excesses, which are possibly due to the binarity, the multiplicity, and/or the debris disk, but in the W 2– W 3 (4.6–12 μ m) region they have no or little infrared excess. In addition, in the 12–22 μ m region, some of Ap stars and Am stars show the infrared excesses and infrared radiations for these Ap and Am stars are probably due to the free–free emissions. In addition, it is seen that the probability of being the binarity, the multiplicity and/or the debris disk for Am stars is much higher than that for Ap stars. Furthermore, it can be seen that, in general, no relations can be found between infrared colors and spectral types either for Ap stars or for Am stars.

A New Photometric Study of Ap and Am Stars in the Infrared

International Nuclear Information System (INIS)

Chen, P. S.; Liu, J. Y.; Shan, H. G.

2017-01-01

In this paper, 426 well known confirmed Ap and Am stars are photometrically studied in the infrared. The 2MASS, Wide-field Infrared Survey Explorer ( WISE ), and IRAS data are employed to make analyses. The results in this paper have shown that in the 1–3 μ m region over 90% Ap and Am stars have no or little infrared excesses, and infrared radiations in the near-infrared from these stars are probably dominated by the free–free emissions. It is also shown that in the 3–12 μ m region, the majority of Ap stars and Am stars have very similar behavior, i.e., in the W 1– W 2 (3.4–4.6 μ m) region, over half of Ap and Am stars have clear infrared excesses, which are possibly due to the binarity, the multiplicity, and/or the debris disk, but in the W 2– W 3 (4.6–12 μ m) region they have no or little infrared excess. In addition, in the 12–22 μ m region, some of Ap stars and Am stars show the infrared excesses and infrared radiations for these Ap and Am stars are probably due to the free–free emissions. In addition, it is seen that the probability of being the binarity, the multiplicity and/or the debris disk for Am stars is much higher than that for Ap stars. Furthermore, it can be seen that, in general, no relations can be found between infrared colors and spectral types either for Ap stars or for Am stars.

AE8/AP8 Implementations in AE9/AP9, IRBEM, and SPENVIS

Science.gov (United States)

2014-02-18

period applies to orbit generation only; AE8/AP8 utilizes geomagnetic field models from other epochs as specified in the table below.) SHIELDOSE2 model...finite and semi- infinite slab data tables for Bremsstrahlung have been reversed [Heynderickx, private communication, May 2013]. This correction is...Cain, J. C., S. J. Hendricks, R. A. Langel, and W. V. Hudson (1967), A proposed model for the international geomagnetic reference field, 1965, J

AP190L and PDP-KI10: a hardware/software measurement report

International Nuclear Information System (INIS)

Maron, N.; Sutherland, G.G.

1979-01-01

This report discusses an AP190L array processor (manufactured by Floating Point Systems of Beaverton, Oregon) interfaced to a PDP-10 (Digital Equipment Corporation, Maynard, Mass.). After AP software installation, an analysis of the overhead was performed. The results of these measurements and some conclusions are presented. An AP monitor and software interface were written to minimize the overhead from the PDP-10. A vector extension to the FORTRAN language called FIVE was developed to increase user access to the AP. Some of the problems associated with defining and implementing FIVE are discussed. Its successes and limitations are reviewed. 2 figures, 2 tables

Prognostic value of Angiographic Perfusion Score (APS) following percutaneous interventions in acute coronary syndromes.

Science.gov (United States)

Narain, V S; Fischer, L; Puri, A; Sethi, R; Dwivedi, S K

2013-01-01

Identifying reperfusion and predicting post procedure risk is important following Percutaneous Coronary Interventions (PCI). An Angiographic Perfusion Score (APS) combining TIMI flow (TFG) and myocardial perfusion (TMPG) grades before and after PCI can accurately measure both epicardial and myocardial perfusion and predict Major Adverse Cardiac Events (MACE). APS was calculated in 226 (88 ST elevation Myocardial Infarction (STEMI) and 138 Non STEMI) patients. Maximum score being 12, reperfusion was defined as failed: 0-3, partial: 4-9, and full APS: 10-12. Thirty day MACE were observed. APS identified reperfusion significantly more than TMPG alone (STEMI: 50.6% vs 11.8% (p APS group (1.8% vs 22.5%) (p APS detects more low risk reperfused patients, post PCI. Copyright © 2012. Published by Elsevier B.V.

Factors influencing the end of the service life of protective gloves used in car repair shops: a preliminary report.

Science.gov (United States)

Emilia, Irzmańska; Agnieszka, Stefko; Katarzyna, Dyńska-Kukulska

2015-01-01

The paper presents the results of an end-of-service-life study on 2 kinds of protective gloves designed for workplaces in which workers are exposed to mineral oils and mechanical factors. The authors developed their own end-of-service-life study method that takes into account factors occurring during real-life use of protective gloves. The examined gloves were subjected to mechanical, chemical, and physical factors. The objective of the study was to compare the protective in new gloves subjected to a laboratory simulation test and in gloves used at workplaces in car repair shops. A further goal was to design a glove assessment procedure that would ensure comprehensive analysis of the actual level of performance provided by gloves exposed to selected chemical and mechanical factors as well as subjected to the influence of temperature and humidity, mechanical damage, and chemical degradation of material. The results lead to the conclusion that simultaneous exposure of protective gloves to mechanical, chemical, and physical factors significantly decreases their performance levels. Furthermore, similar performance levels were obtained for gloves subjected to laboratory simulation tests and for those used in the workplace.

Effect of Fe{sub 2}O{sub 3} in Fe{sub 2}O{sub 3}/AP composite particles on thermal decomposition of AP and on burning rate of the composite propellant

Energy Technology Data Exchange (ETDEWEB)

Ma, Zhenye [National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology, Nanjing, 210094 (China); Nanjing University of Technology, Nanjing (China); Li, Fengsheng; Bai, Huaping [National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology, Nanjing, 210094 (China)

2006-12-15

A technique of composite processing of Fe{sub 2}O{sub 3} and ammonium perchlorate (AP) was employed in making the propellant. The effects of composite processing of Fe{sub 2}O{sub 3} on catalytic activity, on the thermal decomposition of AP, and on the burning rate of the composite propellant were investigated in this paper. Fe{sub 2}O{sub 3}/AP composite particles were prepared by a novel solvent-nonsolvent method. The results show that AP is successfully coated on the surface of Fe{sub 2}O{sub 3}. Composite processing of Fe{sub 2}O{sub 3} and AP can improve the catalytic activity of Fe{sub 2}O{sub 3}. Fe{sub 2}O{sub 3} exhibits better catalytic effect with increasing Fe{sub 2}O{sub 3} content. The larger interface between Fe{sub 2}O{sub 3} and AP and lower density of composite propellant (with the added Fe{sub 2}O{sub 3}/AP composite particles) are responsible for the enhancement of the catalytic activity of Fe{sub 2}O{sub 3}. (Abstract Copyright [2006], Wiley Periodicals, Inc.)

[Psychiatric care act of Ukraine and issues concerning reformation of the mental health protection service].

Science.gov (United States)

Moskalenko, V F; Gorban', E N; Tabachnikov, S I; Syropiatov, O G; Shtengelov, V V

2000-01-01

An analysis was performed of the conception and content of a new Psychiatric Care Act by making a comparison with data from published literature and the present-day status of the mental health protection service. The main features of the crisis of psychiatry in Ukraine are characterized together with possible ways of resolving it. Main trends in reformation of the psychiatric service are identified that are to be secured by relevant acts of departmental and interdepartmental character based on law. Priority is emphasized to defence of the patients' rights and liberties together with a need for a guarantee of a highly skilled medical care to be provided for mental patients.

The Patient Protection and Affordable Care Act and Utilization of Preventive Health Care Services

Directory of Open Access Journals (Sweden)

Victor Eno

2016-02-01

Full Text Available We examined how (a health insurance coverage, and (b familiarity with the Patient Protection and Affordable Care Act (ACA’s or ObamaCare mandate of cost-free access to preventive health services, affect the use of preventive services by residents of a minority community. It was based on primary data collected from a survey conducted during March to April 2012 among a sample of self-identified African American adults in Tallahassee-Leon County area of northwest Florida. The Statistical Package for the Social Sciences (SPSS Version 22 was used for running frequency analysis on the data set and multivariable regression modeling. The results showed that of 524 respondents, 382 (73% had health insurance while 142 (27% lacked insurance. Majority of insured respondents, 332 (87%, used preventive health services. However, the remaining 13% of respondents did not use preventive services because they were unfamiliar with the ACA provision of free access to preventive services for insured people. Regression analysis showed a high (91.04% probability that, among the insured, the use of preventive health services depended on the person’s age, income, and education. For uninsured residents, the lack of health insurance was the key reason for non-use of preventive health services, while among the insured, lack of knowledge about the ACA benefit of free access contributed to non-use of preventive services. Expansion of Medicaid eligibility can increase insurance coverage rates among African Americans and other minority populations. Health promotion and awareness campaigns about the law’s benefits by local and state health departments can enhance the use of preventive services.

The development of renewable resources at Arizona public service company

Energy Technology Data Exchange (ETDEWEB)

Herb Hayden, P.E. [Arizona Public Service Company, (United states)

1995-12-31

Arizona Public Service (APS) has been pursuing the development of solar energy for many years, through feasibility studies, solar monitoring, photovoltaics testing, demonstration projects, and internal applications of solar. Key examples are our comparative testing of photovoltaics (PV) at our Solar Test And Research (STAR) Center, the construction of a 225 kW grid-connected PV system, about 20 kW of rooftop PV systems at several customers properties, our participation in the development of Solar Central Receiver technology, and two recent studies on the value of solar in centralized and distributed generation. The costs and performance of solar technologies has been steadily improving, and there are current needs for energy services in APS service territory which cannot be economically served by power line extensions. These off-grid demands provide an opportunity for the initial application of solar for customer service, which can expand as costs are further reduced. It is expected that with continued development support, the costs of solar will decrease to a level which will be competitive in certain grid-connected applications before 2000. Recently, APS established a goal of installing 12 megawatts of solar by 2000 in applications that are cost-effective or can be made cost effective, for the economic and environmental benefit of our customers and shareholders. In order to achieve this goal, APS will develop cooperative working relationships with suppliers and other utilities that have a similar interest in the cost-effective use of solar energy for customer service. [Espanol] Servicios Publicos de Arizona (APS) ha proseguido el desarrollo de la energia solar desde hace muchos anos a traves de estudios de factibilidad, monitoreo solar, prueba de equipos fotovoltaicos, proyectos de demostracion y aplicaciones internas de energia solar. Son ejemplos importantes nuestras pruebas comparativas de fotovoltaicos (PV) en nuestro Centro de Pruebas e Investigaciones

The development of renewable resources at Arizona public service company

Energy Technology Data Exchange (ETDEWEB)

Herb Hayden, P E [Arizona Public Service Company, (United states)

1996-12-31

Arizona Public Service (APS) has been pursuing the development of solar energy for many years, through feasibility studies, solar monitoring, photovoltaics testing, demonstration projects, and internal applications of solar. Key examples are our comparative testing of photovoltaics (PV) at our Solar Test And Research (STAR) Center, the construction of a 225 kW grid-connected PV system, about 20 kW of rooftop PV systems at several customers properties, our participation in the development of Solar Central Receiver technology, and two recent studies on the value of solar in centralized and distributed generation. The costs and performance of solar technologies has been steadily improving, and there are current needs for energy services in APS service territory which cannot be economically served by power line extensions. These off-grid demands provide an opportunity for the initial application of solar for customer service, which can expand as costs are further reduced. It is expected that with continued development support, the costs of solar will decrease to a level which will be competitive in certain grid-connected applications before 2000. Recently, APS established a goal of installing 12 megawatts of solar by 2000 in applications that are cost-effective or can be made cost effective, for the economic and environmental benefit of our customers and shareholders. In order to achieve this goal, APS will develop cooperative working relationships with suppliers and other utilities that have a similar interest in the cost-effective use of solar energy for customer service. [Espanol] Servicios Publicos de Arizona (APS) ha proseguido el desarrollo de la energia solar desde hace muchos anos a traves de estudios de factibilidad, monitoreo solar, prueba de equipos fotovoltaicos, proyectos de demostracion y aplicaciones internas de energia solar. Son ejemplos importantes nuestras pruebas comparativas de fotovoltaicos (PV) en nuestro Centro de Pruebas e Investigaciones

The Dushak–Erekdag Survey of roAp Stars Tatyana Dorokhova ...

Indian Academy of Sciences (India)

South-African Astronomical Observatory (SAAO). Details of the discovery and further studies are given in Kurtz (1990) and Kurtz & Martinez (2000). Some roAp stars have multiple modes of pulsations and they are valuable for asteroseismological studies. Out of the 32 known roAp stars so far, about 84% were discovered in ...

Protective Services Chili Cookoff Full of Good Food, Good Fun, and “Tough Choices” | Poster

Science.gov (United States)

This year’s Protective Services Chili Cookoff was marked by blazing-hot chili and fiery competition as 15 entrants contended for the attention and adoration of approximately 150 hungry attendees. The competition is a fixture at NCI at Frederick and regularly features an array of culinary concoctions, from which the visitors rank their choices for first, second, and third place.

ION EFFECTS IN THE APS PARTICLE ACCUMULATOR RING

Energy Technology Data Exchange (ETDEWEB)

Calvey, J.; Harkay, K.; Yao, CY.

2017-06-25

Trapped ions in the APS Particle Accumulator Ring (PAR) lead to a positive coherent tune shift in both planes, which increases along the PAR cycle as more ions accumulate. This effect has been studied using an ion simulation code developed at SLAC. After modifying the code to include a realistic vacuum profile, multiple ionization, and the effect of shaking the beam to measure the tune, the simulation agrees well with our measurements. This code has also been used to evaluate the possibility of ion instabilities at the high bunch charge needed for the APS-Upgrade.

Concepts of radiation protection

International Nuclear Information System (INIS)

2013-01-01

This seventh chapter presents the concepts and principles of safety and radiation protection, emergency situations; NORM and TENORM; radiation protection care; radiation protection plan; activities of the radiation protection service; practical rules of radiation protection and the radiation symbol

Children born to SLE and APS mothers.

Science.gov (United States)

Nalli, C; Iodice, A; Andreoli, L; Lojacono, A; Motta, M; Fazzi, E; Tincani, A

2014-10-01

Systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APS) are autoimmune diseases that affect women of childbearing age. Pregnancies in these patients carry several complications such as prematurity. Maternal IgG antiphospholipid antibodies (aPL) can cross the placenta but they don't generally cause any neonatal thrombotic event. Because of the incompleteness of the fetal blood-brain barrier, aPL could theoretically reach the fetal brain. Whether this can have an effect on brain development is still under investigation. Some studies performed in children of patients with SLE and/or APS showed an increased number of learning disabilities without impairment in intelligence level. The objectives of this article are to evaluate the neurodevelopment outcome in 30 children (median age 9 years) born to mothers with SLE and/or APS with IgG anti-beta2-glycoprotein I during the third trimester of pregnancy and found positive for the same antibodies at birth. A neurological physical exam was performed in all children. We submitted some questionnaires to the mothers: the Child Behavior CheckList (CBCL) and a homemade set of questions obtained by a team composed of rheumatologists and pediatric neurologists. Intellectual functioning was determined by the Wechsler scale for corrected age. In all children neurological physical exam and intelligence levels were found to be normal but mild behavior disorders and history of neurological manifestations were shown in three children. Offspring of patients with SLE and/or APS are generally healthy. We and others observed the occurrence of minor neurological disorders that might be related to maternal disease or to prematurity. The limited number of the available data on this sensitive issue supports the need for further studies. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Mapping potential freshwater services, and their representation within Protected Areas (PAs, under conditions of sparse data. Pilot implementation for Cambodia

Directory of Open Access Journals (Sweden)

Leonardo Sáenz

2016-07-01

Full Text Available Freshwater is arguably one of Earth’s most threatened natural resources, on which more than 7 billion people depend. Pressures on freshwater resources from infrastructure, resource development, agricultural pollution and deforestation are mounting, particularly in developing countries. To date, conservation responses such as Protected Areas (PAs have not typically targeted freshwater ecosystems and their services, and thus little is known about the effectiveness of these efforts in protecting them. This paper proposes and pilots an innovative freshwater services metrics framework to quantify the representation of potential freshwater services in PAs under conditions of scarce data, with a pilot application for Cambodia. Our results indicate that conservation actions have more effectively represented potential freshwater regulation services than potential freshwater provisioning services, with major rivers remaining generally unprotected. Results from the framework are then used to propose a series of context and region specific management options to improve the conservation of freshwater services in Cambodia. There is an acute need for such management options, as the country’s food security depends largely on important freshwater ecosystems such as the Tonle Sap Lake and the deep water pools systems of the Mekong River. The framework proposed can be applied in other countries or large river basins to explore the degree of representation of freshwater services within PAs systems, under conditions of sparse data.

Recessive loss-of-function mutations in AP4S1 cause mild fever-sensitive seizures, developmental delay and spastic paraplegia through loss of AP-4 complex assembly

DEFF Research Database (Denmark)

Hardies, Katia; May, Patrick; Djémié, Tania

2015-01-01

We report two siblings with infantile onset seizures, severe developmental delay and spastic paraplegia, in whom whole-genome sequencing revealed compound heterozygous mutations in the AP4S1 gene, encoding the σ subunit of the adaptor protein complex 4 (AP-4). The effect of the predicted loss-of-...... in reported patients, highlighting that seizures are part of the clinical manifestation of the AP-4 deficiency syndrome. We also hypothesize that endosomal trafficking is a common theme between heritable spastic paraplegia and some inherited epilepsies....

The modularization construction of piping system installation in AP1000 plant

International Nuclear Information System (INIS)

Lu Song; Wang Yuan; Wei Junming

2012-01-01

Modularization construction is the main technique used in AP1000 plants, the piping Modularization installation will impact directly to the module construction as the important part of the Modularization construction. After the piping system has took the modularization design in AP1000 plants, some installation works of piping system has moved from the site to fabrication shop. With improving the construction quality and minimizing the time frame of project, the critical paths can be optimized. This paper has analyzed the risk and challenge that met during the modularization construction period of piping systems though introducing the characteristic of modularization construction for AP1000 piping systems, and get construction experiences from the First AP1000 plants in the world, then it will be the firmly basics for the wide application of modularization construction in the future. (authors)

Intermediate-break LOCA analyses for the AP600 design

International Nuclear Information System (INIS)

Boyack, B.E.; Lime, J.F.

1995-01-01

A postulated double-ended guillotine break of a direct-vessel-injection line in an AP600 plant has been analyzed. This event is characterized as an intermediate break loss-of-coolant accident (IBLOCA). Most of the insights regarding the response of the AP600 safety systems to the postulated accident are derived from calculations performed with the TRAC-PFl/MOD2 code. However, complementary insights derived from a scaled experiment conducted in the ROSA facility, as well as insights based upon calculations by other codes, are also presented. The key processes occurring in an AP600 during a IBLOCA are primary coolant system depressurization, inventory depletion, inventory replacement via emergency core coolant injection, continuous core cooling, and long-term decay heat rejection to the atmosphere. Based upon the calculated and experimental results, the AP600 will not experience a core heat up and will reach a safe shutdown state using only safety-class equipment. Only the early part of the long-term cooling period initiated by In-containment Refueling Water Storage Tank injection was evaluated Thus, the observation that the core is continuously cooled should be verified for the latter phase of the long-term cooling period, the interval when sump injection and containment cooling processes are important

Comparison of CPR1000 and AP1000 rod position indication systems

International Nuclear Information System (INIS)

Lei Qing

2009-01-01

This paper introduces the structure, the function, the digital detection principle of reactor control rod position and monitoring systems in CPR1000 and AP1000, comparing with the characteristics of the system design. The results show that the operation mode and function of AP1000 Rod position indication system are similar to that of CPR1000, but AP1000 rod position system provides higher reliability, and reduces the numbers of containment electrical penetrations and is with better characteristics than that of CPR1000, since it incorporated the redundancy design and data communication. (authors)

Non-conventional antiphospholipid antibodies in patients with clinical obstetrical APS: Prevalence and treatment efficacy in pregnancies.

Science.gov (United States)

Mekinian, Arsène; Bourrienne, Marie-Charlotte; Carbillon, Lionel; Benbara, Amélie; Noémie, Abisror; Chollet-Martin, Sylvie; Tigaizin, Ahmed; Montestruc, Francois; Fain, Olivier; Nicaise-Roland, Pascale

2016-10-01

To describe the prevalence of non-conventional APL in patients with obstetrical APS without conventional APL and the impact of treatment on pregnancy outcome. Patients with clinical obstetrical criteria were tested for anti-phosphatidylethanolamine (aPE) IgG/M, anti-prothrombin/phosphatidylserine (anti-PS/PT) IgG/M, and anti-annexin V IgG. Pregnancy losses rates were compared between APS, non-conventional APS, and non-APL and in untreated pregnancies to treated ones for each group. Using the cutoffs (ROC), 65/96 (68%) patients have been considered as non-conventional APS and compared to 83 APS and 31 patients without APL. The obstetrical history in non-conventional APS did not differ in comparison to confirmed APS. The frequencies of anti-annexin V IgG antibodies tended to be more frequent in non-conventional APS (88% versus 73%; p = 0.06), and those of anti-PE IgG and M were similar. The anti-PS/PT IgG and M antibodies were more frequent in confirmed APS than in non-conventional APS (63% and 37% versus 4% and 5%, respectively, p APS were compared with 81 pregnancies of confirmed APS and 132 pregnancies from non-APL group. Out of 474, 136 (29%) patients have been treated during pregnancies, and treatment significantly increased the rate of live birth (26% in untreated versus 72% in treated pregnancies, p APS and non-conventional APS, with odds ratio at 3.3 (95% CI: 1.8-6.1) and 6.9 (95% CI: 3.9-12.3) (p = 0.49) and significantly more important for the 2 APS groups pooled versus non-APL group [OR at 1.9 (95% CI: 1.1-3.5) for non-APL group versus 5.3 (95% CI: 3.5-8.1) for APS groups, p = 0.0025]. In this study, 68% of patients with clinical criteria for obstetrical APS seronegative for conventional APL have non-conventional APL. These patients have a significant decrement of pregnancy losses if they receive treatment for APS during their pregnancy. Copyright © 2016 Elsevier Inc. All rights reserved.

Introduction to sump screen downstream effect analysis of AP1000 nuclear power plant

International Nuclear Information System (INIS)

Zhang Qinghua; Liu Yu; Chai Guohan

2010-01-01

The design of AP1000 takes into account the potential impact of debris clogging on sump screen. In this article, the technical background of sump screen issue and the design characteristics of AP1000 to address the sump screen blockage issue are introduced. The article focuses on the 'downstream effect' analysis method, acceptance criteria and analysis result of AP1000 sump screen. Although the design of AP1000 is different with traditional PWR, the author expects to bring some reference to advance the downstream effect analysis in China through the introduction. (authors)

Tank characterization report for double-shell Tank 241-AP-107

International Nuclear Information System (INIS)

DeLorenzo, D.S.; Simpson, B.C.

1994-01-01

The purpose of this tank characterization report is to describe and characterize the waste in Double-Shell Tank 241-AP-107 based on information gathered from various sources. This report summarizes the available information regarding the waste in Tank 241-AP-107, and arranges it in a useful format for making management and technical decisions concerning this particular waste tank. In addition, conclusion and recommendations based on safety and further characterization needs are given. Specific objectives reached by the sampling and characterization of the waste in Tank 241-AP-107 are: Contribute toward the fulfillment of the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) Milestone M-44-05 concerning the characterization of Hanford Site high-level radioactive waste tanks; Complete safety screening of the contents of Tank 241-AP-107 to meet the characterization requirements of the Defense Nuclear Facilities Safety board (DNFSB) Recommendation 93-5; and Provide tank waste characterization to the Tank Waste Remediation System (TWRS) Program Elements in accordance with the TWRS Tank Waste Analysis Plan

Argonne National Laboratory high performance network support of APS experiments

International Nuclear Information System (INIS)

Knot, M.J.; McMahon, R.J.

1996-01-01

Argonne National Laboratory is currently positioned to provide access to high performance regional and national networks. Much of the impetus for this effort is the anticipated needs of the upcoming experimental program at the APS. Some APS collaborative access teams (CATs) are already pressing for network speed improvements and security enhancements. Requirements range from the need for high data rate, secure transmission of experimental data, to the desire to establish a open-quote open-quote virtual experimental environment close-quote close-quote at their home institution. In the near future, 155 megabit/sec (Mb/s) national and regional asynchronous transfer mode (ATM) networks will be operational and available to APS users. Full-video teleconferencing, virtual presence operation of experiments, and high speed, secure transmission of data are being tested and, in some cases, will be operational. We expect these efforts to enable a substantial improvement in the speed of processing experimental results as well as an increase in convenience to the APS experimentalist. copyright 1996 American Institute of Physics

The Best of Both Worlds? Free Trade in Services and EU Law on Privacy and Data Protection

NARCIS (Netherlands)

Yakovleva, S.; Irion, K.

2016-01-01

The article focuses on the interplay between European Union (EU) law on privacy and data protection and international trade law, in particular the General Agreement on Trade in Services (GATS) and the WTO dispute settlement system. The argument distinguishes between the effects of international

Permanent education that approaches radiation protection in hemodynamic service; Educacao permanente que aborde radioprotecao em servico de hemodinamica

Energy Technology Data Exchange (ETDEWEB)

Flor, Rita de Cassia; Anjos, Djeniffer Valdirene dos, E-mail: flor@ifsc.edu.b [Instituto Federal de Santa Catarina (IF-SC), Florianopolis, SC (Brazil)

2011-10-26

In the hemodynamic services that apply ionizing radiation yet exist the necessity of capacitation of workers for actuation in those areas. So, this qualitative study performed in a hemodynamic service at Sao Jose, Santa Catarina, Brazil, had the objective to analyse how are developed the permanent education programs and the real necessity of workers. The results have shown that the workers are longing for their qualification and formation, as generally they are admitted with not any qualification for those services. So, the workers that realize the on duty hemodynamic service praxis must do it in a conscious manner and the E P is a way for to adopt good practice in radiological protection

AP Geography, Environmental Science Thrive

Science.gov (United States)

Robelen, Erik W.

2012-01-01

Geography may not be particularly known as a hot topic among today's students--even some advocates suggest it suffers from an image problem--but by at least one measure, the subject is starting to come into its own. Across more than 30 topics covered in the Advanced Placement (AP) program, participation in geography is rising faster than any…

Synthesis and binding properties of new selective ligands for the nucleobase opposite the AP site.

Science.gov (United States)

Abe, Yukiko; Nakagawa, Osamu; Yamaguchi, Rie; Sasaki, Shigeki

2012-06-01

DNA is continuously damaged by endogenous and exogenous factors such as oxidative stress or DNA alkylating agents. These damaged nucleobases are removed by DNA N-glycosylase and form apurinic/apyrimidinic sites (AP sites) as intermediates in the base excision repair (BER) pathway. AP sites are also representative DNA damages formed by spontaneous hydrolysis. The AP sites block DNA polymerase and a mismatch nucleobase is inserted opposite the AP sites by polymerization to cause acute toxicities and mutations. Thus, AP site specific compounds have attracted much attention for therapeutic and diagnostic purposes. In this study, we have developed nucleobase-polyamine conjugates as the AP site binding ligand by expecting that the nucleobase part would play a role in the specific recognition of the nucleobase opposite the AP site by the Watson-Crick base pair formation and that the polyamine part should contribute to the access of the ligand to the AP site by a non-specific interaction to the DNA phosphate backbone. The nucleobase conjugated with 3,3'-diaminodipropylamine (A-ligand, G-ligand, C-ligand, T-ligand and U-ligand) showed a specific stabilization of the duplex containing the AP site depending on the complementary combination with the nucleobase opposite the AP site; that is A-ligand to T, G-ligand to C, C-ligand to G, T- and U-ligand to A. The thermodynamic binding parameters clearly indicated that the specific stabilization is due to specific binding of the ligands to the complementary AP site. These results have suggested that the complementary base pairs of the Watson-Crick type are formed at the AP site. Copyright © 2012 Elsevier Ltd. All rights reserved.

APS- and XPS-investigations of vanadium, vanadium carbide and graphite

Energy Technology Data Exchange (ETDEWEB)

Bradshaw, A M; Krause, U [Technische Univ. Muenchen (F.R. Germany). Inst. fuer Physikalische Chemie und Theoretische Chemie

1975-11-01

Soft X-ray appearance potential spectroscopy (APS) and X-ray photoelectron spectroscopy (XPS) have been used to study vanadium, vanadium carbide, and graphite. The chemical shifts for vanadium carbide with respect to metallic vanadium and graphite are compared for the two methods. The Csub(K) structure in APS and the valence band in XPS for vanadium carbide show good agreement with the band structure calculations of Neckel and co-workers. Using the band structure calculations of Painter et al. it is also shown how the multi-peak structure in the APS spectrum of graphite is possibly due to density of states effects. It would therefore appear that plasmon coupling plays only a minor role.

BPM STABILTIY STUDIES FOR THE APS MBA UPGRADE

Energy Technology Data Exchange (ETDEWEB)

Lill, R.; Sereno, N.; Yang, B.

2017-03-25

The Advanced Photon Source (APS) is currently in the preliminary design phase for the multi-bend achromat (MBA) lattice upgrade. Beam stability is critical for the MBA and will require long term drift defined as beam mo-tion over a seven-day timescale to be no more than 1 mi-cron at the insertion device locations and beam angle change no more than 0.25 micro-radian. Mechanical stabil-ity of beam position monitor (BPM) pickup electrodes mounted on insertion device vacuum chambers place a fun-damental limitation on long-term beam stability for inser-tion device beamlines. We present the design and imple-mentation of prototype mechanical motion system (MMS) instrumentation for quantifying this type of motion specif-ically in the APS accelerator tunnel and experiment hall floor under normal operating conditions. The MMS pres-ently provides critical position information on the vacuum chamber and BPM support systems. Initial results of the R&D prototype systems have demonstrated that the cham-ber movements far exceed the long-term drift tolerance specified for the APS Upgrade MBA storage ring.

Species and size diversity in protective services offered by coral guard-crabs

Directory of Open Access Journals (Sweden)

C. Seabird McKeon

2014-09-01

Full Text Available Coral guard-crabs in the genus Trapezia are well-documented defenders of their pocilloporid coral hosts against coral predators such as the Crown-of-Thorns seastar (Acanthaster planci complex. The objectives of this study were to examine the protective services of six species of Trapezia against corallivory, and the extent of functional diversity among these Trapezia species.Studies conducted in Mo’orea, French Polynesia showed the Trapezia—coral mutualism protected the host corals from multiple predators through functional diversity in the assemblage of crab symbionts. Species differed in their defensive efficacy, but species within similar size classes shared similar abilities. Smaller-size Trapezia species, which were previously thought to be ineffective guards, play important defensive roles against small corallivores.We also measured the benefits of this mutualism to corals in the midst of an Acanthaster outbreak that reduced the live coral cover on the fore reef to less than 4%. The mutualism may positively affect the reef coral demography and potential for recovery during adverse predation events through shelter of multiple species of small corals near the host coral. Our results show that while functional diversity is supported within the genus, some Trapezia species may be functionally equivalent within the same size class, decreasing the threat of gaps in coral protection caused by absence or replacement of any single Trapezia species.

Amphioxus and lamprey AP-2 genes: implications for neural crest evolution and migration patterns

Science.gov (United States)

Meulemans, Daniel; Bronner-Fraser, Marianne

2002-01-01

The neural crest is a uniquely vertebrate cell type present in the most basal vertebrates, but not in cephalochordates. We have studied differences in regulation of the neural crest marker AP-2 across two evolutionary transitions: invertebrate to vertebrate, and agnathan to gnathostome. Isolation and comparison of amphioxus, lamprey and axolotl AP-2 reveals its extensive expansion in the vertebrate dorsal neural tube and pharyngeal arches, implying co-option of AP-2 genes by neural crest cells early in vertebrate evolution. Expression in non-neural ectoderm is a conserved feature in amphioxus and vertebrates, suggesting an ancient role for AP-2 genes in this tissue. There is also common expression in subsets of ventrolateral neurons in the anterior neural tube, consistent with a primitive role in brain development. Comparison of AP-2 expression in axolotl and lamprey suggests an elaboration of cranial neural crest patterning in gnathostomes. However, migration of AP-2-expressing neural crest cells medial to the pharyngeal arch mesoderm appears to be a primitive feature retained in all vertebrates. Because AP-2 has essential roles in cranial neural crest differentiation and proliferation, the co-option of AP-2 by neural crest cells in the vertebrate lineage was a potentially crucial event in vertebrate evolution.

Comparison and analysis for item classifications between AP1000 and traditional PWR

International Nuclear Information System (INIS)

Luo Shuiyun; Liu Xiaoyan

2012-01-01

The comparison and analysis for the safety classification, seismic category, code classification and QA classification between AP1000 and traditional PWR were presented. The safety could be guaranteed and the construction and manufacture costs could be cut down since all sorts of AP1000 classifications. It is suggested that the QA classification and the QA requirements correspond to the national conditions should be drafted in the process of AP1000 domestication. (authors)

Hydrogen Assisted Crack in Dissimilar Metal Welds for Subsea Service under Cathodic Protection

Science.gov (United States)

Bourgeois, Desmond

Dissimilar metal welds (DMWs) are routinely used in the oil and gas industries for structural joining of high strength steels in order to eliminate the need for post weld heat treatment (PWHT) after field welding. There have been reported catastrophic failures in these DMWs, particularly the AISI 8630 steel - Alloy 625 DMW combination, during subsea service while under cathodic protection (CP). This is due to local embrittlement that occurs in susceptible microstructures that are present at the weld fusion boundary region. This type of cracking is known as hydrogen assisted cracking (HAC) and it is influenced by base/filler metal combination, and welding and PWHT procedures. DMWs of two material combinations (8630 steel -- Alloy 625 and F22 steel -- Alloy 625), produced with two welding procedures (BS1 and BS3) in as welded and PWHT conditions were investigated in this study. The main objectives included: 1) evaluation of the effect of materials composition, welding and PWHT procedures on the gradients of composition, microstructure, and properties in the dissimilar transition region and on the susceptibility to HAC; 2) investigation of the influence of microstructure on the HAC failure mechanism and identification of microstructural constituents acting as crack nucleation and propagation sites; 3) assessment of the applicability of two-step PWHT to improve the resistance to HAC in DMWs; 4) establishment of non-failure criterion for the delayed hydrogen cracking test (DHCT) that is applicable for qualification of DMWs for subsea service under cathodic protection (CP).

DL-2-amino-3-phosphonopropionic acid protects primary neurons from oxygen-glucose deprivation induced injury

Directory of Open Access Journals (Sweden)

Di Cui

2017-02-01

Full Text Available Cerebral infarction is a type of ischemic stroke and is one of the main causes of irreversible brain damage. Although multiple neuroprotective agents have been investigated recently, the potential of DL-2-amino-3-phosphonopropionic acid (DL-AP3 in treating oxygen-glucose deprivation (OGD-induced neuronal injury, has not been clarified yet. This study was aimed to explore the role of DL-AP3 in primary neuronal cell cultures. Primary neurons were divided into four groups: (1 a control group that was not treated; (2 DL-AP3 group treated with 10 μM of DL-AP3; (3 OGD group, in which neurons were cultured under OGD conditions; and (4 OGD + DL-AP3 group, in which OGD model was first established and then the cells were treated with 10 μM of DL-AP3. Neuronal viability and apoptosis were measured using Cell Counting Kit-8 and flow cytometry. Expressions of phospho-Akt1 (p-Akt1 and cytochrome c were detected using Western blot. The results showed that DL-AP3 did not affect neuronal viability and apoptosis in DL-AP3 group, nor it changed p-Akt1 and cytochrome c expression (p > 0.05. In OGD + DL-AP3 group, DL-AP3 significantly attenuated the inhibitory effects of OGD on neuronal viability (p < 0.001, and reduced OGD induced apoptosis (p < 0.01. Additionally, the down-regulation of p-Akt1 and up-regulation of cytochrome c, induced by OGD, were recovered to some extent after DL-AP3 treatment (p < 0.05 or p < 0.001. Overall, DL-AP3 could protect primary neurons from OGD-induced injury by affecting the viability and apoptosis of neurons, and by regulating the expressions of p-Akt1 and cytochrome c.

Power supply control units for APS ring magnets

International Nuclear Information System (INIS)

Despe, O.D.

1990-01-01

The APS storage ring (1104 meters) is divided into 40 sectors. Each sector has 38 magnet coils in five magnet bases. Every alternate sector has an additional quadrupole magnet for skew correction. AR the main dipole magnets, two in each sector are connected in series and fed from one power supply unit. A base is controlled by one power supply control unit (PSCU). Each PSCU is connected to the host computer via a local area network (LAN). This note discusses the hardware configuration of the typical power supply control system used by the APS magnets and the software commands supported by the PSCU

Comparison of a CCD and an APS for soft x-ray diffraction

OpenAIRE

Stewart, G.; Bates, R.; Blue, A.; Clark, A.; Dhesi, S.S.; Maneuski, D.; Marchal, J.; Steadman, P.; Tartoni, N.; Turchetta, R.

2011-01-01

We compare a new CMOS Active Pixel Sensor (APS) to a Princeton Instruments PIXIS-XO: 2048B Charge Coupled Device (CCD) with soft X-rays tested in a synchrotron beam line at the Diamond Light Source (DLS). Despite CCDs being established in the field of scientific imaging, APS are an innovative technology that offers advantages over CCDs. These include faster readout, higher operational temperature, in-pixel electronics for advanced image processing and reduced manufacturing cost.\\ud \\ud The AP...

Joint Service Aircrew Mask (JSAM) - Tactical Aircraft (TA) A/P22P-14A Respirator Assembly (V)3: Noise Attenuation and Speech Intelligibility Performance with Double Hearing Protection, HGU-55A/P JHMCS Flight Helmet

Science.gov (United States)

2017-03-01

descried in the Purchase Description (PD)3 as shown below. Hearing Protection / Noise Attenuation The JSAM-TA, when integrated with existing head...Continuous or Impulsive Noise Using Microphone-in-Real-Ear or Acoustic Test Fixture Procedures4. Correction factors were applied using the computation...and measurements were concluded there. The decision to not proceed with measurements at 75 dBA is detailed in the discussion. 3.0 DISCUSSION

Protecting HIV information in countries scaling up HIV services: a baseline study.

Science.gov (United States)

Beck, Eduard J; Mandalia, Sundhiya; Harling, Guy; Santas, Xenophon M; Mosure, Debra; Delay, Paul R

2011-02-06

Individual-level data are needed to optimize clinical care and monitor and evaluate HIV services. Confidentiality and security of such data must be safeguarded to avoid stigmatization and discrimination of people living with HIV. We set out to assess the extent that countries scaling up HIV services have developed and implemented guidelines to protect the confidentiality and security of HIV information. Questionnaires were sent to UNAIDS field staff in 98 middle- and lower-income countries, some reportedly with guidelines (G-countries) and others intending to develop them (NG-countries). Responses were scored, aggregated and weighted to produce standard scores for six categories: information governance, country policies, data collection, data storage, data transfer and data access. Responses were analyzed using regression analyses for associations with national HIV prevalence, gross national income per capita, OECD income, receiving US PEPFAR funding, and being a G- or NG-country. Differences between G- and NG-countries were investigated using non-parametric methods. Higher information governance scores were observed for G-countries compared with NG-countries; no differences were observed between country policies or data collection categories. However, for data storage, data transfer and data access, G-countries had lower scores compared with NG-countries. No significant associations were observed between country score and HIV prevalence, per capita gross national income, OECD economic category, and whether countries had received PEPFAR funding. Few countries, including G-countries, had developed comprehensive guidelines on protecting the confidentiality and security of HIV information. Countries must develop their own guidelines, using established frameworks to guide their efforts, and may require assistance in adapting, adopting and implementing them.

Experimental study of 99Tcm-Ap4A in detection of atherosclerotic plaques

International Nuclear Information System (INIS)

Cao Wei; Zhang Yongxue; An Rui

2001-01-01

Objective: To study 99 Tc m labelled di-adenosine tetraphosphate (Ap4A), a compound can bind on P 2 purine receptors on atherosclerotic lesions, for imaging experimental atherosclerotic plaques in New Zealand White (NZW) rabbits. Methods: Twenty male NZW rabbits were submitted immune-injury and fed with high cholesterol diet for more than 2 months. To label the 99 Tc m to Ap4A, stannous tartrate solution was used. 99 Tc m -Ap4A was purified on a Sephadex G-25 column and tested for radiochemistry purity on thin layer chromatography. A biodistribution study was carried out on KM mice. Thirty minutes after intravenous injection of 7.4 MBq 99 Tc m -Ap4A, 5 normal NZW rabbits and 5 NZW rabbits with atherosclerotic lesions were sacrificed; their abdominal aortas were removed and covered with X-ray films. Exposed for 24 h in refrigerator, the films were developed and fixed. In another 5 NZW rabbits with atherosclerotic lesions, blood samples, atherosclerotic plaques and normal aortic wall samples were removed. Lesion to blood (target/blood, T/B), lesion to normal (target/non-target, T/NT) radioactivity ratios were calculated. 74 MBq 99 Tc m -Ap4A was injected into marginal ear veins of 5 atherosclerotic and 5 normal NZW rabbits. Simultaneously in vivo images were recorded for more than 4 h. In another group, 30 min after 99 Tc m -Ap4A administration, the animals were sacrificed and their abdominal aortas were removed. The abdominal aortas were placed on the face of SPECT and images acquisition was performed. Results: The radiochemistry purity of 99 Tc m -Ap4A was 85% to 91%. Biodistribution study revealed the clearance of 99 Tc m -Ap4A from blood was rapid. Thirty min after 99 Tc m -Ap4A administration, T/B radio was 3.17 +- 1.27, T/NT ratio was 5.23 +- 1.87. On the radioautography film shadows of atherosclerotic plaques were clearly visible. The atherosclerotic plaques on the aorta samples also can be seen on ex vivo images. Atherosclerotic abdominal aortas and lesions

Dyslipidemia and its relationship with antiphospholipid antibodies in APS patients in North Kerala.

Science.gov (United States)

Sadanand, Shajit; Paul, Binoy J; Thachil, Emil J; Meletath, Rejadheesh

2016-12-01

Antiphospholipid antibody syndrome (APS) is one of the most common acquired thrombophilic disorders resulting in arterial and venous thromboses. APS is a major cause for cerebrovascular accidents or stokes, myocardial infarction, venous thromboembolism and recurrent abortions/pregnancy losses especially in young patients. APS patients have an increased risk of atherosclerotic cardiovascular events. There are only two studies on lipid abnormalities in APS patients. None of them have studied the relationship between individual laboratory tests for APS and lipid profile abnormalities. Here we describe the significance of the relationship between various APS tests and lipid profile abnormalities in a subset of APS patients who presented with arterial thrombosis in a tertiary care hospital. The study was conducted at Government Medical College, which is a tertiary care referral hospital. All patients who presented to the medicine department with APS during a two-year period were studied. A patient was considered to be positive for anticardiolipin (aCL) antibody or anti-β2 glycoprotein (anti-β2G) if the titer was more than 15 IU/mL, and a high titer was considered to be more than 40 IU/mL for Immunoglobulin (lg) IgG and IgM isotypes. The fasting lipid profile was measured in all patients, and lipid profile abnormalities were defined with cutoffs of low-density lipoprotein (LDL) levels of >150 mg/dL, triglyceride (TG) levels of >150 mg/dL, and high-density lipoprotein (HDL) levels of APS, aCL IgG and IgM and anti-β2G IgG and IgM, were determined by statistical analysis. The study population included 77 APS patients, with 53% of patients between 20 and 40 years. The commonest abnormality in the lipid profile test was elevated TG levels of >150 mg/dL in 51.9% of the patients, followed by low HDL levels (150 mg/dL) in 40.2% of the patients. There was a statistically significant relationship between anti-β2G IgG levels and HDL and LDL levels, but not TG levels. Only LDL

Protection as care: moral reasoning and moral orientation among ethnically and socioeconomically diverse older women.

Science.gov (United States)

Dakin, Emily

2014-01-01

This study examined moral reasoning among ethnically and socioeconomically diverse older women based on the care and justice moral orientations reflecting theoretical frameworks developed by Carol Gilligan and Lawrence Kohlberg, respectively. A major gap in this area of research and theory development has been the lack of examination of moral reasoning in later life. This study addressed this gap by assessing socioeconomically and ethnically diverse older women's reasoning in response to ethical dilemmas showing conflict between autonomy, representative of Kohlberg's justice orientation, and protection, representative of Gilligan's care orientation. The dilemmas used in this study came from adult protective services (APS), the U.S. system that investigates and intervenes in cases of elder abuse and neglect. Subjects were 88 African American, Latina, and Caucasian women age 60 or over from varying socioeconomic status backgrounds who participated in eight focus groups. Overall, participants favored protection over autonomy in responding to the case scenarios. Their reasoning in responding to these dilemmas reflected an ethic of care and responsibility and a recognition of the limitations of autonomy. This reasoning is highly consistent with the care orientation. Variations in the overall ethic of care and responsibility based on ethnicity and SES also are discussed. Copyright © 2013. Published by Elsevier Inc.

Eucalyptus globulus extract protects against UVB-induced photoaging by enhancing collagen synthesis via regulation of TGF-β/Smad signals and attenuation of AP-1.

Science.gov (United States)

Park, Bom; Hwang, Eunson; Seo, Seul A; Cho, Jin-Gyeong; Yang, Jung-Eun; Yi, Tae-Hoo

2018-01-01

UV irradiation triggers the overproduction of matrix metalloproteinases and collagen degradation, which in turn causes increased pigmentation, dryness, and deep wrinkling of the skin. These chronic symptoms are collectively referred to as photoaging. Eucalyptus globulus is an evergreen tree that is widely used in cosmetics because of its antimicrobial activity. In this study, we investigated the protective effect of 50% ethanol extracts of Eucalyptus globulus on UV-induced photoaging in vitro and in vivo. Normal human dermal fibroblasts were treated with Eucalyptus globulus at concentrations ranging from 1 to 100 μg/mL after UVB or non-UVB irradiation. We found that Eucalyptus globulus suppressed the expression of MMPs and IL-6, but increased the expression of TGF-β1 and procollagen type 1. In addition, Eucalyptus globulus inhibited activation of the AP-1 transcription factor, an inducer of MMPs. Eucalyptus globulus was also found to regulate TGF-β/Smad signaling by reversing the activity of negative Smad regulators. Lastly, in vivo studies showed that topical application of Eucalyptus globulus on UVB-irradiated hairless mice reduced wrinkle formation and dryness by down-regulating MMP-1 and up-regulating expression of elastin, TGF-β1, and procollagen type 1. Taken together, these data suggest that Eucalyptus globulus may be a useful agent in cosmetic products. Copyright © 2017 Elsevier Inc. All rights reserved.

What do we know about the cardiac valve lesion in the antiphospholipid syndrome (APS)?

Science.gov (United States)

Amigo, M-C

2014-10-01

Heart valve disease (HVD) is the most common cardiac manifestation in the antiphospholipid syndrome (APS). Valve lesions should be described according to the established definition. HVD is progressive despite anticoagulant/antiplatelet treatments. Around 4-6% of patients with HVD in APS will require valve replacement surgery, which is considered a very high risk procedure in APS. Unfortunately, no recommendations regarding medical treatment of antiphospholipid antibodies-associated HVD can be made at this moment. There are evidence-based data and strong pathophysiologic rationale for considering HVD as a manifestation of APS. Thus, HVD should be included as a criterion of definite APS. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Tank 241-AP-104 Grab Sampling and Analysis Plan

International Nuclear Information System (INIS)

TEMPLETON, A.M.

2000-01-01

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AP-104. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AP-104 required to provide sample material to the Waste Treatment Contractor. Grab samples will be obtained from riser 001 to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives and ICD-23. The 222-S Laboratory will receive samples; composite the samples; perform chemical analyses on composite samples; and provide samples to the Waste Treatment Contractor and the Process Chemistry Laboratory. The Process Chemistry Laboratory at the 222-S Laboratory Complex will perform process tests to evaluate the behavior of the 241-AP-104 waste undergoing the retrieval and treatment scenarios defined in the applicable DQOs. The Waste Treatment Contractor will perform process verification and waste form qualification tests. Requirements for analyses of samples originating in the L and H DQO process tests will be documented in the corresponding test plan (Person 2000) and are not within the scope of this SAP. This report provides the general methodology and procedures to be used in the preparation, retrieval, transport, analysis, and reporting of results from grab samples retrieved from tank 241-AP-104

[Cloning, subcellular localization, and heterologous expression of ApNAC1 gene from Andrographis paniculata].

Science.gov (United States)

Wang, Jian; Qi, Meng-Die; Guo, Juan; Shen, Ye; Lin, Hui-Xin; Huang, Lu-Qi

2017-03-01

Andrographis paniculata is widely used as medicinal herb in China for a long time and andrographolide is its main medicinal constituent. To investigate the underlying andrographolide biosynthesis mechanisms, RNA-seq for A. paniculata leaves with MeJA treatment was performed. In A. paniculata transcriptomic data, the expression pattern of one member of NAC transcription factor family (ApNAC1) matched with andrographolide accumulation. The coding sequence of ApNAC1 was cloned by RT-PCR, and GenBank accession number was KY196416. The analysis of bioinformatics showed that the gene encodes a peptide of 323 amino acids, with a predicted relative molecular weight of 35.9 kDa and isoelectric point of 6.14. To confirm the subcellular localization, ApNAC1-GFP was transiently expressed in A. paniculata protoplast. The results indicated that ApNAC1 is a nucleus-localized protein. The analysis of real-time quantitative PCR revealed that ApNAC1 gene predominantly expresses in leaves. Compared with control sample, its expression abundance sharply increased with methyl jasmonate treatment. Based on its expression pattern, ApNAC1 gene might involve in andrographolide biosynthesis. ApNAC1 was heterologously expressed in Escherichia coli and recombinant protein was purified by Ni-NTA agarose. Further study will help us to understand the function of ApNAC1 in andrographolide biosynthesis. Copyright© by the Chinese Pharmaceutical Association.

Magnetic Measurements of Storage Ring Magnets for the APS Upgrade Project

Energy Technology Data Exchange (ETDEWEB)

Doose, C.; Dejus, R.; Jaski, M.; Jansma, W.; Collins, J.; Donnelly, A.; Liu, J.; Cease, H.; Decker, G.; Jain, A.; DiMarco, J.

2017-06-01

Extensive prototyping of storage ring magnets is ongoing at the Advanced Photon Source (APS) in support of the APS Multi-Bend Achromat (MBA) upgrade project (APS-U) [1]. As part of the R&D activities four quadrupole magnets with slightly different geometries and pole tip materials, and one sextupole magnet with vanadium permendur (VP) pole tips were designed, built and tested. Magnets were measured individually using a rotating coil and a Hall probe for detailed mapping of the magnetic field. Magnets were then assembled and aligned relative to each other on a steel support plate and concrete plinth using precision machined surfaces to gain experience with the alignment method chosen for the APS-U storage ring magnets. The required alignment of magnets on a common support structure is 30 μm rms. Measurements of magnetic field quality, strength and magnet alignment after subjecting the magnets and assemblies to different tests are presented.

State-of-the-Art developments in accelerator controls at the APS

International Nuclear Information System (INIS)

Lenkszus, F.

1999-01-01

The performance requirements of the Advanced Photon Source (APS) challenge the control system in a number of areas. This paper will review a few applications of advanced technology in the control and monitoring of the APS. The application of digital signal processors (DSPs) and techniques will be discussed, both from the perspective of a large distributed multiprocessor system and from that of embedded systems. In particular, two embedded applications will be highlighted, a beam position monitor processor and a DSP-based power supply controller. Fast data distribution is often a requirement. The application of a high-speed network based on reflective memory will also be discussed in the context of the APS global orbit feedback system. Timing systems provide opportunities to apply technologies such as high-speed logic and fiber optics. Examples of the use of these technologies will also be included. Finally, every modern accelerator control system of any size requires networking. Features of the APS accelerator controls network will be discussed

Antiphospholipid syndrome (APS) revisited: Would migraine headaches be included in future classification criteria?

Science.gov (United States)

Noureldine, Mohammad Hassan A; Haydar, Ali A; Berjawi, Ahmad; Elnawar, Rody; Sweid, Ahmad; Khamashta, Munther A; Hughes, Graham R V; Uthman, Imad

2017-02-01

Headaches have been extensively reported in Antiphospholipid syndrome (APS)/Antiphospholipid antibodies (aPL)-positive patients. The aim of this study was to highlight the prevalence of headaches among APS/aPL-positive patients and discuss its association with laboratory, clinical and imaging findings. We searched the literature through Google Scholar and PubMed for publications on the epidemiology, pathogenesis, laboratory, imaging and clinical findings, and management of headaches in APS/aPL-positive patients. The following keywords were used: Antiphospholipid, Hughes syndrome, anticardiolipin, lupus anticoagulant, anti-β2 glycoprotein I, headache, migraine, tension, and cluster. All reports published between 1969 and 2015 were included. Migraine is the most commonly reported type of headache in APS/aPL-positive patients. Thrombotic and platelet dysfunction hypotheses have been studied to uncover the pathogenic role of aPL in the development of headaches. Several studies are reporting higher levels of aPL in primary and secondary APS migraineurs, but only few reached statistical significance. Migraine patients without clinical signs/symptoms of cerebral infarction rarely show positive imaging findings. Digital subtraction angiography shows promise in demonstrating small vascular lesions otherwise not detected on computed tomography, magnetic resonance imaging, or cerebral angiograms. Although it may be solitary and harmless in many cases, the deleterious effect of migraine on the quality of life of APS patients prompts rapid diagnosis and proper management. An anticoagulation trial is advisable in APS patients with migraine as many cases of severe, refractory migraine resolved with anticoagulation therapy. The profile of migraine headaches discussed in this study permits its candidacy for inclusion in future APS classification criteria.

Overview of the advanced photon source (APS)

International Nuclear Information System (INIS)

White, M.M.

1994-01-01

The Advanced Photon Source (APS) is a state-of-the-art synchrotron light source facility dedicated to the production of extremely brilliant x-ray beams for research. Its super-intense x-ray beams will be used in many areas of research including industrial research, biological and medical research, defense-related research, and basic research. The APS x-ray beams will allow scientists to study smaller samples, more complex systems, faster reactions and processes, and gather data at a greater level of detail than has been possible to date. Creation of these beams begins with electron production by an electron gun with a thermionic cathode. The electrons are accelerated to 200 MeV by a linear accelerator (linac) and then impinge on a tungsten target, resulting in electron-positron pair production. The positrons are accelerated to 450 MeV in the remainder of the linac, then accumulated, damped, and transferred to a synchrotron that increases their energy to 7 GeV. The 7-GeV positrons are injected into a storage ring, where they pass through special magnets that cause them to emit x-rays of the desired quality. Construction at ANL is nearly complete at this time, and the APS will begin operating for users in 1996. The accelerator and experimental facilities are described in this paper, and a brief overview of some of the experimental programs is given

The APS control system network upgrade

International Nuclear Information System (INIS)

Sidorowicz, K. v.; Leibfritz, D.; McDowell, W. P.

1999-01-01

When it was installed,the Advanced Photon Source (APS) control system network was at the state-of-the-art. Different aspects of the system have been reported at previous meetings [1,2]. As loads on the controls network have increased due to newer and faster workstations and front-end computers, we have found performance of the system declining and have implemented an upgraded network. There have been dramatic advances in networking hardware in the last several years. The upgraded APS controls network replaces the original FDDI backbone and shared Ethernet hubs with redundant gigabit uplinks and fully switched 10/100 Ethernet switches with backplane fabrics in excess of 20 Gbits/s (Gbps). The central collapsed backbone FDDI concentrator has been replaced with a Gigabit Ethernet switch with greater than 30 Gbps backplane fabric. Full redundancy of the system has been maintained. This paper will discuss this upgrade and include performance data and performance comparisons with the original network

Expansion and Functional Divergence of AP2 Group Genes in Spermatophytes Determined by Molecular Evolution and Arabidopsis Mutant Analysis

Directory of Open Access Journals (Sweden)

Pengkai Wang

2016-09-01

Full Text Available The APETALA2 (AP2 genes represent the AP2 group within a large group of DNA-binding proteins called AP2/EREBP. The AP2 gene is functional and necessary for flower development, stem cell maintenance, and seed development, whereas the other members of AP2 group redundantly affect flowering time. Here we study the phylogeny of AP2 group genes in spermatophytes. Spermatophyte AP2 group genes can be classified into AP2 and TOE types, six clades, and we found that the AP2 group homologs in gymnosperms belong to the AP2 type, whereas TOE types are absent, which indicates the AP2 type gene are more ancient and TOE type was split out of AP2 type and losing the major function. In Brassicaceae, the expansion of AP2 and TOE type lead to the gene number of AP2 group were up to six. Purifying selection appears to have been the primary driving force of spermatophyte AP2 group evolution, although positive selection occurred in the AP2 clade. The transition from exon to intron of AtAP2 in Arabidopsis mutant leads to the loss of gene function and the same situation was found in AtTOE2. Combining this evolutionary analysis and published research, the results suggest that typical AP2 group genes may first appear in gymnosperms and diverged in angiosperms, following expansion of group members and functional differentiation. In angiosperms, AP2 genes (AP2 clade inherited key functions from ancestors and other genes of AP2 group lost most function but just remained flowering time controlling in gene formation. In this study, the phylogenies of AP2 group genes in spermatophytes was analyzed, which supported the evidence for the research of gene functional evolution of AP2 group.

''Ftorlon'' coats for corrosion protection of electrodialysis units

International Nuclear Information System (INIS)

Shigorina, I.I.; Egorov, B.N.; Kalinkin, A.V.; Kapustin, A.F.; Shigorin, V.G.; Smirnova, N.M.

1983-01-01

This article examines the coats for protecting components of electrodialysis units (housing, frames, etc.) with respect to chemical stability, electric insulation properties, and with reference to atomic power station (APS) decontamination and radiation resistance. The physicomechanical properties of the coats were investigated by the standard methods. The radiation resistance of the coats was judged from the change in their physicomechanical and protective properties in corrosive media by placing the coat samples in the gamma-field of a Co 60 source at an intensity of 3.5-4 Gr/sec. Recommends the coat SP-CSPE-31 based on chlorosulfonated polythylene (TU-11-118-74) for corrosion protection of the EDU bulky equipment designed for desalination of sea water for industrial and household purposes

Energetics and dynamics of the non-natural fluorescent 4AP:DAP base pair

KAUST Repository

Chawla, Mohit

2018-01-02

The fluorescent non-natural 4-aminophthalimide (4AP) base, when paired to the complementary 2,4-diaminopyrimidine (DAP) nucleobase, is accommodated in a B-DNA duplex being efficiently recognized and incorporated by DNA polymerases. To complement the experimental studies and rationalize the impact of the above non-natural bases on the structure, stability and dynamics of nucleic acid structures, we performed quantum mechanics (QM) calculations along with classical molecular dynamics (MD) simulations. QM calculations were initially focused on the geometry and energetics of the 4AP:DAP non-natural pair and of H-bonded base pairs between 4AP and all the natural bases in their classical Watson-Crick geometries. The QM calculations indicate that the 4AP:DAP pair, despite the fact that it can form 3 H-bonds in a classic Watson-Crick geometry, has a stability comparable to the A:T pair. Then, we extended the study to reverse Watson-Crick geometries, characteristic of parallel strands. MD simulations were carried out on two 13-mer DNA duplexes, featuring a central 4AP:DAP or A:T pair, respectively. No major structural deformation of the duplex was observed during the MD simulation. Snapshots from the MD simulations were subjected to QM calculations to investigate the 4AP:DAP interaction energy when embedded into a duplex structure, and to investigate the impact of the two non-natural bases on the stacking interactions with adjacent bases in the DNA duplex. We found a slight increase in stacking interactions involving the 4AP:DAP pair, counterbalanced by a moderate decrease in H-bonding interactions of the 4AP:DAP and of the adjacent base pairs in the duplex. The results of our study are in agreement with experimental data and complement them by providing an insight into which factors contribute positively and which factors contribute negatively to the structural compatibility of the fluorescent 4AP:DAP pair with a B-DNA structure.

Development of the Assistance to Participate Scale (APS) for children's play and leisure activities.

Science.gov (United States)

Bourke-Taylor, H; Law, M; Howie, L; Pallant, J F

2009-09-01

This paper describes the development and psychometric evaluation of the Assistance to Participate Scale (APS). The APS measures the assistance that a school-aged child with a disability requires to participate in play and leisure activities from the primary carer's perspective. Mixed methodology using an instrument design model was used to complete two studies. First, a qualitative research design was used to generate items and scoring criteria for the APS. Second, a quantitative study evaluated the instrument using data collected from 152 mothers with children aged 5-18 years. Statistical analysis assessed the underlying structure, internal consistency and construct validity of the APS. Exploratory factor analysis revealed two correlated components, reflecting home-based and community-based play activities. Both subscales and the total APS scale showed good internal consistency. The APS correlated as predicted with individual domains and overall scores for other validated measures (Pediatric Evaluation of Disability Inventory caregiver scales and Pediatric Quality of Life Inventory) with correlations ranging from rho = 0.42 to rho = 0.77. The APS was able to discriminate between groups of children based on type of schooling (regular or segregated), need for equipment/assistive devices, frequency of lifting and disability. The APS provides professionals with a brief psychometrically sound tool that measures the amount of caregiver assistance provided to a child with a disability to participate in play and recreation. The APS may be used as an outcome measure and to evaluate and predict the amount and type of additional assistance families need to facilitate their child's participation in an important aspect of the child's daily life and development: play and recreation.

Understanding and Using the New Guided-Inquiry AP Chemistry Laboratory Manual

Science.gov (United States)

Cacciatore, Kristen L.

2014-01-01

To support teaching and learning in the advanced placement (AP) chemistry laboratory, the College Board published a laboratory manual, "AP Chemistry Guided-Inquiry Experiments: Applying the Science Practices," in 2013 as part of the redesigned course. This article provides a discussion of the rationale for the existence of the manual as…

Panel Discussion : Report of the APS Ad-Hoc Committee on LGBT Issues

Science.gov (United States)

Atherton, Tim; Barthelemy, Ramon; Garmon, Savannah; Reeves, Kyle; APS Ad-Hoc Committee on LGBT Issues Team

Following the presentation of the findings and recommendations of the APS Ad-Hoc Committee on LGBT Issues (C-LGBT) by Committee Chair Michael Falk, a panel discussion will be held featuring several members of the committee. The discussion will focus on how APS can best ensure the recommendations of the committee are carried out in a timely fashion and other ideas on future APS efforts toward LGBT inclusion in physics. Discussion topics will also include the research and other input that shaped the committee's findings and recommendations.

Postural tachycardia syndrome (POTS) and other autonomic disorders in antiphospholipid (Hughes) syndrome (APS).

Science.gov (United States)

Schofield, J R; Blitshteyn, S; Shoenfeld, Y; Hughes, G R V

2014-06-01

Antiphospholipid syndrome (APS) is an autoimmune hypercoagulable disorder that has been shown to cause a large number of cardiac and neurological manifestations. Two recent studies have demonstrated abnormalities in cardiovascular autonomic function testing in APS patients without other cardiovascular or autoimmune disease. However, an association between autonomic disorders such as postural tachycardia syndrome and APS has not previously been described. Data were obtained by retrospective chart review. We identified 15 patients who have been diagnosed with APS and an autonomic disorder. The median age of the patients at the time of data analysis was 39 years. The autonomic disorders seen in these patients included postural tachycardia syndrome, neurocardiogenic syncope and orthostatic hypotension. The majority of patients (14/15) were female and the majority (14/15) had non-thrombotic neurological manifestations of APS, most commonly migraine, memory loss and balance disorder. Many also had livedo reticularis (11/15) and Raynaud's phenomenon (nine of 15). In some patients, the autonomic manifestations improved with anticoagulation and/or anti-platelet therapy; in others they did not. Two patients with postural tachycardia syndrome who failed to improve with the usual treatment of APS have been treated with intravenous immunoglobulin with significant improvement in their autonomic symptoms. We believe that autonomic disorders in APS may represent an important clinical association with significant implications for treatment. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Accessing and disclosing protected resources

DEFF Research Database (Denmark)

Olesen, Henning; Khajuria, Samant

2014-01-01

TODAY, DATA IS MONEY. Whether it is private users’ personal data or confidential data and assets belonging to service providers, all parties have a strong need to protect their resources when interacting with each other, i.e. for access control and authorization. For service providers and enterpr......TODAY, DATA IS MONEY. Whether it is private users’ personal data or confidential data and assets belonging to service providers, all parties have a strong need to protect their resources when interacting with each other, i.e. for access control and authorization. For service providers...... and enterprises resources are usually well safeguarded, while private users are often missing the tools and the know-how to protect their own data and preserve their privacy. The user’s personal data have become an economic asset, not necessarily to the owners of these data, but to the service providers, whose...... business mod- els often includes the use of these data. In this paper we focus on the user – service provider interaction and discuss how recent technological progress, in particular the framework of User Managed Access (UMA), can enable users to understand the value of their protected resources...

Tank 241-AP-104 tank characterization plan

International Nuclear Information System (INIS)

Homi, C.S.

1995-11-01

This document is a plan that identifies the information needed to address relevant issues concerning short-term and long-term safe storage and long-term management of Double-Shell Tank (DST) 241-AP-104

Implementation of QoSS (Quality-of-Security Service) for NoC-Based SoC Protection

Science.gov (United States)

Sepúlveda, Johanna; Pires, Ricardo; Strum, Marius; Chau, Wang Jiang

Many of the current electronic systems embedded in a SoC (System-on-Chip) are used to capture, store, manipulate and access critical data, as well as to perform other key functions. In such a scenario, security is considered as an important issue. The Network-on-chip (NoC), as the foreseen communication structure of next-generation SoC devices, can be used to efficiently incorporate security. Our work proposes the implementation of QoSS (Quality of Security Service) to overcome present SoC vulnerabilities. QoSS is a novel concept for data protection that introduces security as a dimension of QoS. In this paper, we present the implementation of two security services (access control and authentication), that may be configured to assume one from several possible levels, the implementation of a technique to avoid denial-of-service (DoS) attacks, evaluate their effectiveness and estimate their impact on NoC performance.

Using a Classroom Response System to Improve Multiple-Choice Performance in AP[R] Physics

Science.gov (United States)

Bertrand, Peggy

2009-01-01

Participation in rigorous high school courses such as Advanced Placement (AP[R]) Physics increases the likelihood of college success, especially for students who are traditionally underserved. Tackling difficult multiple-choice exams should be part of any AP program because well-constructed multiple-choice questions, such as those on AP exams and…

Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval.

Directory of Open Access Journals (Sweden)

Jennifer Hirst

2018-01-01

Full Text Available The AP-5 adaptor protein complex is presumed to function in membrane traffic, but so far nothing is known about its pathway or its cargo. We have used CRISPR-Cas9 to knock out the AP-5 ζ subunit gene, AP5Z1, in HeLa cells, and then analysed the phenotype by subcellular fractionation profiling and quantitative mass spectrometry. The retromer complex had an altered steady-state distribution in the knockout cells, and several Golgi proteins, including GOLIM4 and GOLM1, were depleted from vesicle-enriched fractions. Immunolocalisation showed that loss of AP-5 led to impaired retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR, GOLIM4, and GOLM1 from endosomes back to the Golgi region. Knocking down the retromer complex exacerbated this phenotype. Both the CIMPR and sortilin interacted with the AP-5-associated protein SPG15 in pull-down assays, and we propose that sortilin may act as a link between Golgi proteins and the AP-5/SPG11/SPG15 complex. Together, our findings suggest that AP-5 functions in a novel sorting step out of late endosomes, acting as a backup pathway for retromer. This provides a mechanistic explanation for why mutations in AP-5/SPG11/SPG15 cause cells to accumulate aberrant endolysosomes, and highlights the role of endosome/lysosome dysfunction in the pathology of hereditary spastic paraplegia and other neurodegenerative disorders.

Expression of activator protein-1 (AP-1) family members in breast cancer

International Nuclear Information System (INIS)

Kharman-Biz, Amirhossein; Gao, Hui; Ghiasvand, Reza; Zhao, Chunyan; Zendehdel, Kazem; Dahlman-Wright, Karin