International Nuclear Information System (INIS)

The purpose was to study the toxicity of drugs known to generate free radicals on isolated pancreatic islets. The accumulattion of "8"6Rb"+ by mouse pancreatic islets was measured in vitro. Exposing the islets to 6-hydroxydopamine, minhydrin, or phenazine methosulphate + NADH inhibited the Rb"+ uptake, whereas paraquat or acetylphenylhydrazine had no effect. This effect of 6-hydroxydopamine was prevented by either of the hydroxyl radical scavengers, sodium benzoate and mannitol, but not by the non-scavenger,urea; ninhydrin was partially protected against by mannitol but not by benzoate. Protection against 6-hydroxydopamine was also afforded by D-glucose but not by L-glucose or 3-O-methyl-D-glucose; none of the sugars protected against ninhydrin. In damaging islet beta-cells and in being protected against by D-glucose, 6-hydroxydopamine closely resembles the ...

UK PubMed Central (United Kingdom)

Extracellular ATP has been proposed as a paracrine signal in rodent islets, but it is unclear what role ATP plays in human islets. We now show the presence of an ATP signaling pathway that enhances...Full Text Available

UK PubMed Central (United Kingdom)

ObjectiveThe goal of the study was to investigate the genetic and molecular basis of a novel syndrome of marked hyperglucagonemia and pancreatic α cell hyperplasia...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The typical MRI features of the most common pancreatic diseases, such as pancreatitis and adenocarcinoma of the pancreas, have been established. However, even in these common pancreatic disorders, MRI correlation with the underlying pathology is limited for clinical reasons. We emphasize MR-pathological correlation of inflammatory and neoplastic pancreatic changes, including pancreatitis, adenocarcinoma, acinar cell carcinoma, rare cystic and solid pancreatic neoplasms, and islet cell tumors. By highlighting the correlation of key pathological features with MR findings, a better understanding of the MR appearance of pancreatic pathology can be provided. In addition, MRI may prove a powerful tool in detection and characterization of pancreatic tumors. (orig.) [Deutsch] Das MR-tomographische ...

International Nuclear Information System (INIS)

Insulitis is considered the histopathological hallmark of type I diabetes. In the non-obese diabetic (NOD) mouse, diabetes has never been observed in the absence of insulitis. The in vivo detection of insulitis could be of relevance for early prediction of diabetes. As approximately 15% of islet-infiltrating lymphocytes express interleukin 2 receptors, the authors have labelled recombinant inter-leukin 2 with "1"2"3I and used this radiopharmaceutical to detect insulitis by gamma camera imaging. The authors studied 71 prediabetic NOD and 27 normal Balb/c mice. Labelled #alpha#-lactalbumin was used as the control protein. In the first set of experiments the tissue distribution of radiolabelled interleukin 2 in isolated organs from animals sacrificed at different time points was studied. Higher radioactivity was detected in the pancreas of NOD mice injected with labelled interleukin 2, as compared to NOD mice receiving labelled #alpha#-lactalbumin. In another set of ...

UK PubMed Central (United Kingdom)

Walled-off pancreatic necrosis (WOPN), formerly known as pancreatic abscess is a late complication of acute pancreatitis. It can be lethal, even though it is rare. This critical review provides an overview...Full Text Available

UK PubMed Central (United Kingdom)

Standard pancreatic resections, such as pancreaticoduodenectomy, distal pancreatectomy, or total pancreatectomy, result in an important loss of normal pancreatic parenchyma and may cause impairment...Full Text Available

Science.gov (United States)

Pancreatic Cancer; Head and Neck Cancer; Breast Cancer

UK PubMed Central (United Kingdom)

We have identified the nonreceptor tyrosine kinase syk as a marker of differentiation/tumor suppressor in pancreatic ductal adenocarcinoma (PDAC). Syk expression is lost in poorly differentiated PDAC...Full Text Available

UK PubMed Central (United Kingdom)

Objectives:Cachexia is common in pancreatic cancer and may have an influence on longterm survival but few studies have investigated this in patients with operable tumours. Therefore,...Full Text Available

UK PubMed Central (United Kingdom)

Patients with pancreatic cancer normally present with advanced disease that is lethal and notoriously difficult to treat. Survival has not improved dramatically, despite routine use of chemotherapy...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundASCL1 role in pancreatic endocrine tumourigenesis has not been established. Recently it was suggested that ASCL1 negatively controls expression of the...Full Text Available

UK PubMed Central (United Kingdom)

We examined the association between N-acetyltransferase 1 and 2 (NAT1 and NAT2) haplotype and risk of pancreatic cancer by genotyping eight...Full Text Available

UK PubMed Central (United Kingdom)

AIM: To distinguish anastomotic from parenchymal leakage at duct-to-mucosa reconstruction of the pancreatic remnant.METHODS: We reviewed the charts of 68 pancreaticod-uodenectomies performed...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe elevated serum and peritoneal cytokine concentrations responsible for the systemic response syndrome (SIRS) and multiorgan failure in patients with severe acute pancreatitis...Full Text Available

UK PubMed Central (United Kingdom)

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancy with dismal prognosis and few effective therapeutic options. Novel agents that are safe and effective are urgently...Full Text Available

UK PubMed Central (United Kingdom)

Autoimmune pancreatitis is frequently associated with elevated serum and tissue IgG4 levels in the adult population, but there are few reports of pediatric autoimmune pancreatitis, and even fewer reports...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundDNA repair is the general term for the collection of critical mechanisms which repair many forms of DNA damage such as methylation or ionizing radiation. DNA repair has...Full Text Available

UK PubMed Central (United Kingdom)

Background:Solid pseudopapillary tumor is a rare pancreatic neoplasm with uncertain to low malignant potential. This is an uncommon neoplasm with many pseudonyms, occurring...Full Text Available

UK PubMed Central (United Kingdom)

A 33-year-old man sustained an acute Achilles tendon rupture which was surgically repaired. Early nonweight-bearing range of motion and strengthening of the ankle and the repaired muscle unit was allowed...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVEThe purpose of this study was to determine the effect of posterior repair (PR) on sexual function in patients who have undergone incontinence and/or pelvic...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Pancreatitis-associated protein (PAP) is a secretory pancreatic protein present in small amounts in normal pancreas and overexpressed during the acute phase of pancreatitis. In this paper, the authors describe the cloning, characterization, and chromosomal mapping of the human PAP gene. The gene spans 2748 bp and contains six exons interrupted by five introns. The gene has a typical promoter containing the sequences TATAAA and CCAAT 28 and 52 bp upstream of the cap site, respectively. They found striking similarities in genomic organization as well as in the promoter sequences between the human and rat PAP genes. The human PAP gene was mapped to chromosome 2p12 using rodent-human hybrid cells and in situ chromosomal hybridization. This localization coincides with that of the reg/lithostathine gene, which encodes a pancreatic secretory protein structurally related to PAP, suggesting that both genes ...

Science.gov (United States)

The following topics are discussed: insertion of incorrect bases in DNA; ability of DNA polymerase to copy uv-irradiated DNA; role of enzymes in repair of DNA; effects of uv radiation on molecular weight of DNA; photoreactivation; repair of DNA in Escherichia coli and xp cells following uv radiation; and synchrotron radiation studies on DNA repair. (HLW)

British Library Electronic Table of Contents (United Kingdom)

Nonfunctioning pancreatic endocrine tumors (PETs) are rare and generally asymptomatic. A 68-year-old woman who had refused treatment for a pancreatic mass, revealed by ultrasonography to be 55 mm in diameter, was referred to us again 29 months later with jaundice. Investigations showed an 82-mm tumor in the head of pancreas, exposed from the papilla of Vater to the duodenal lumen. After biliary decompression and drainage, we performed pancreatoduodenectomy with resection of the portal vein and superior mesenteric vein, followed by reconstruction using a cylindrically customized autologous graft harvested from the right ovarian vein. The tumor was resected curatively. Microscopically, it consisted of trabecular and ribbon-like arrangement of neoplastic cells. Immunohistochemical staining wa...

UK PubMed Central (United Kingdom)

1. Proteolytic enzyme activities were examined in the pancreas of zinc-deficient and control rats. 2. No change was detected in trypsin-plus-chymotrypsin activity. 3. Carboxypeptidase activity was...Full Text Available

UK PubMed Central (United Kingdom)

We report here a case of a pathologically proven solitary fibrous tumor of the pancreas. A 54-year-old man was referred to our hospital for further evaluation of a pancreatic mass that was found incidentally....Full Text Available

UK PubMed Central (United Kingdom)

Menin, which is encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, is a tumor suppressor and transcriptional regulator. Menin controls proliferation and apoptosis of cells, especially pancreatic...Full Text Available

UK PubMed Central (United Kingdom)

Middle segment pancreatectomy (MSP) is a new operation where the advantages of parenchymal preservation are counterbalanced by a high postoperative complication rate and unease among surgeons with adopting...Full Text Available

UK PubMed Central (United Kingdom)

Endoscopic Retrograde Cholangiopancreatography (ERCP) is a widely used diagnostic and therapeutic modality in the management of biliary and pancreatic disease. Some of the complications of the procedure,...Full Text Available

UK PubMed Central (United Kingdom)

DNA double-strand breaks (DSBs) and other lesions occur frequently during cell growth and in meiosis. These are often repaired by homologous recombination (HR). HR may result in the formation of DNA...Full Text Available

UK PubMed Central (United Kingdom)

Platelet-derived growth factor (PDGF) is a potent moderator of soft tissue repair through induction of the inflammatory phase of repair and subsequent enhanced collagen deposition. We examined the effect...Full Text Available

UK PubMed Central (United Kingdom)

The new percutaneous mitral valve repair techniques are at an early stage. Preliminary series show that they are feasible; however, they need to be further evaluated in comparison with contemporary...Full Text Available

UK PubMed Central (United Kingdom)

The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells...Full Text Available

Science.gov (United States)

... Development Document for Proposed Effluent Limitations Guidelines and Standards for the Shipbuilding and Repair Point Source Category (Draft ...

Science.gov (United States)

... Abstract : High temperature testing of graphite/epoxy laminates and composite sandwich panels was performed while the Shuttle was on orbit to ...

Science.gov (United States)

The results of research on the evaluation of the half-bead weld repair method for use on nuclear reactor components are reviewed from data obtained on thick-section test pieces and intermediate-size pressure vessels. Material properties, the magnitude of residual stresses and the structural behavior of flawed pressure vessels are being obtained to determine the adequacy of the weld repair method for application in thick-section components.

British Library Electronic Table of Contents (United Kingdom)

Meiji (Mischief) coral atoll, in Nansha (Spratly) Islands, South China Sea, consists of an annular reef rim surrounding a central lagoon. On the atoll rim there are either protuberant ?motu? (small coral patch reefs on the rim of atoll) islets or lower sandy cays that contain modern microbialite deposits on the corals in pinnacles and surrounding bottoms of the atoll. Microbialites, including villiform, hairy, and thin spine growth forms, as well as gelatinous masses, mats and encrustation, developed on coral colonies and atoll rim sediments between 0 and 15 m deep-water settings. The microbialites were produced by natural populations of filamentous cyanobacteria and grew on (1) bulbous corals together with Acropora sp., (2) on massive colonies of Galaxea fascicularis, (3) on dead Montipor...

British Library Electronic Table of Contents (United Kingdom)

Background Laparoscopic inguinal hernia repair has been around since the 1990s. A novel surgical approach known as laparoendoscopic single-site surgery (LESS) has been developed to reduce the port-related morbidities and improve the cosmetic outcomes of laparoscopic surgery, including totally extraperitoneal (TEP) inguinal hernia repair. The aim of the present study was to evaluate the safety and feasibility of the LESS TEP technique for inguinal hernia repair and compare the outcomes with the standard TEP approach. Methods Between January and May 2009, 54 consecutive healthy patients (48 men and 6 women) underwent LESS TEP inguinal hernia repair at our institute. All procedures were performed using our homemade single port for simultaneous passage of the laparoscope and instruments. The p...

International Nuclear Information System (INIS)

The solid-pseudopapillary tumor (SPT) of the pancreas is a rare type of exocrine pancreatic neoplasm. SPT predominantly affects young women and female children, and is usually discovered incidentally. This tumor is generally benign with a low incidence of malignancy. A 13-year-old girl was admitted to the hospital with a few weeks' history of mild abdominal pain and jaundice. On physical examination, there was no palpable mass. The laboratory tests showed increased SR, CRP, high bilirubin, amylase and lipase serum levels. Ultrasound imaging revealed a solid lesion in the region of the pancreatic head. On MRI, precise tumor localization in the head of the pancreas with pancreatic duct dilatation and compression of the common bile duct were visualized. Pancreaticoduodenectomy and cholecystectomy was performed with good clinical outcome. Microscopic and immunohistochemical studies indicated that tumor cells were typical of SPT ...

Energy Technology Data Exchange (ETDEWEB)

Two local repair procedures, one without (9) and the other with (14) a bulbocavernosus muscle graft were performed on 20 patients with a radiation induced rectovaginal fistula. Four patients had two procedures successively. The initial success rate of both procedures was 7/9 and 14/14 respectively. Though the initial result of the bulbocavernosus graft was obviously better, in many of the local repair procedures, subclinical radiation damage progressed, resulting in recurrence of rectovaginal fistula (5), rectovesical fistula (4), pararectal abscess (2) etc. After a mean follow up of around 10 years, the success rate of fistula repair decreased to 5/9 and 13/14 and only 2/9 and 6/14 finally remained without a colostomy. A local repair operation should be restricted to carefully selected cases. The musculus gracilis is proposed as a better vascular graft. If the general condition of the patient does not ...

Science.gov (United States)

This student manual, part of a small-engine repair series on servicing fuel systems, is designed for use by special needs students in Texas. The manual explains in pictures and short sentences, written on a low reading level, the job of servicing two-piece flo-jet carburetors. Along with the steps of this repair job, specific safety and caution information is frequently noted. To reinforce consistency in material presented to the slow learners, the pictures and written words correspond exactly with the pictures and wording on a corresponding audiovisual presentation. A progress chart for rating the students is included in the manual. (KC)

Science.gov (United States)

... Ashton WS, Puntel RA, Wiswell TE. A rapid and readily available repair of the peripherally inserted central catheter in the nursery. NEONATAL INTENSIVE CARE 11 ...

UK PubMed Central (United Kingdom)

Telomeres protect the chromosome ends from unscheduled DNA repair and degradation. Telomeres are heterochromatic domains composed of repetitive DNA (TTAGGG repeats) bound to an array of specialized...Full Text Available

Medline Plus

... stenosis. It looks from the transesophageal and the 3-D echo that most of the problem is really ... posterior leaflet, which you can see on the 3-D echo image is a major source. The anterior ...

Science.gov (United States)

... of electronic systems (satellite terminals, radio and ... helps organizations investigate the stochastic nature of ... cycle time, maximum queue lengths, and ...

Energy Technology Data Exchange (ETDEWEB)

During a regular inspection of the Boiler Auxiliaries at one of the Dutch Electricity Production Companies serious cracks were found in the cover and casings of the feed water circulation pumps in two units after 108.000 and 122.000 hours of boiler operation. Kema Laboratories carried out Failure analyses on boat samples at the cracked areas. Corrosion fatigue cracking was found on the inner side of the GS-24CrNiMo325 casing. Shop Weld repairs were carried out using a newly developed mechanized Plasma Welding Technique. The repaired feed water circulation pumps showed no problems alter several years of operation. The costs of repair were substantially lower than the costs of replacement. (orig.) 3 refs.

International Nuclear Information System (INIS)

(Jun 1974). United States Hart, RW Setlow, RB Oak Ridge National Lab.,

Medline Plus

... very difficult to help get better and to rehabilitate and sometimes even need surgery. 00:04:21 ... step of treatment, from our standpoint, is to rehabilitate, to strengthen the shoulder. And the real key ...

Energy Technology Data Exchange (ETDEWEB)

This bulletin describes case studies of trucks operating on ethanol fuel. Cost, maintenance and repair, as well as fuel economy are discussed.

Science.gov (United States)

Includes airports, hangars and runways; aircraft repair and overhaul ...... F 100-PW-220 and. Flt0-GE.t00 engines: A case study ol risk assessment ...

UK PubMed Central (United Kingdom)

The nucleotide sequence of the 5'-terminal oligonucleotides produced by pancreatic RNase digestion of bacteriophage T3 RNA polymerase (EC 2.7.7.6) transcripts of T3 DNA has been determined. The sequence...Full Text Available

UK PubMed Central (United Kingdom)

Transforming growth factor (TGF)-beta isoforms (TGF-beta 1, -beta 2, and -beta 3) regulate cell growth and differentiation and have critical regulatory roles in the process of tissue repair and remodeling....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Defects in mismatch repair genes cause the genetic instability characteristic of hereditary nonpolyposis colorectal cancer and a subset of sporadic colon tumors. The newest member of the mismatch repair gene family, GTBP, has recently been identified as a partial cDNA. Here, we describe the isolation of its 5{prime} terminus, allowing definition of the entire coding region. Several polymorphisms within the 5{prime} end were identified and are presented. 13 refs., 1 fig.

UK PubMed Central (United Kingdom)

BackgroundThe mitochondrial genome of the Octocorallia has several characteristics atypical for metazoans, including a novel gene suggested to function in DNA repair. This mtMutS...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Experiments were performed to investigate the involvement of the cell membrane in the excision DNA repair process in Escherichia coli. Two membrane-binding drugs, procaine and phenethyl alcohol (PEA), inhibited liquid-holding recovery (LBR) in u.v.-irradiated E. coli wild-type and recA strains. In uvrB and polA strains where, after u.v.-irradiation, LHR was absent the two drugs had no effect. Both drugs markedly reduced the removal of u.v.-induced thymine dimers in the DNA of wild-type cells (H/r30). Analysis by alkaline sucrose gradients revealed that PEA inhibited the incision step in excision repair. In contrast, procaine had no effect on incision but apparently inhibited the late steps in excision repair. PEA dissociated DNA from the cell membrane, whereas procaine did not. The results suggest that the two drugs PEA and procaine inhibit LHR and the excision repair process operating on u.v.-induced ...

British Library Electronic Table of Contents (United Kingdom)

Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into chondrocytes, osteoblasts, myocytes, adipocytes, and a variety of other cell types. Several studies have been directed toward using MSCs from patients with osteoarthritis (OA) for cartilage repair, not only because these are the ones that will require a source of autologous stem cells if biological repair of cartilage lesions is to be a therapeutic option, but also to further an understanding of stem cell differentiation. Previous studies have shown that a major drawback of current cartilage and intervertebral disc tissue repair is that human MSCs from OA patients express type X collagen (COL X). COL X, a marker of late-stage chondrocyte hypertrophy, is implicated in endochondral ossification. However, those st...

Energy Technology Data Exchange (ETDEWEB)

Purpose of this item is to report the CT patterns of pancreatic mesenchymal lesions and to investigate the capabilities and limitations of this technique in terms of characterization. In selected cases, CT can provide virtually diagnostic information (lipoma and teratoma), or at least highly suggestive findings (NHL, plexiform neurofibroma, lymphangioma). Moreover, knowledge of the variable morphostructural patterns of mesenchymal hisototypes (SCH, Sarcoma etc.) permits to include them in the differential diagnosis of pancreatic masses. [Italian] Scopo di questo rapporto e' descrivere gli aspetti semeiologici dei tumori mesenchimali del pancreas con la TC verificandone le possibilita e i limiti per la caratterizzazione. Pur nella rarita' dei reperti considerati, la TC puo' consentire l'effettiva caratterizzazione in alcuni casi (lipoma, neurofibroma plessiforme, linfangioma) o includere anche istotipi meno ...

UK PubMed Central (United Kingdom)

The astonishingly efficient location and excision of damaged DNA bases by DNA repair glycosylases is an especially intriguing problem in biology. One example is the enzyme uracil DNA glycosylase (UNG),...Full Text Available

UK PubMed Central (United Kingdom)

Leakage after oesophageal anastomosis or perforation remains a challenge for the surgeon. Traditional management has been operative repair or intensive conservative management. Both treatments are...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundCalcitonin gene related peptide (CGRP) is a neuropeptide that is abundant in the sensory neurons which innervate bone. The effects of CGRP on isolated bone cells have been...Full Text Available

UK PubMed Central (United Kingdom)

SUMMARYSmall bowel epithelium is at the frontline of intestinal barrier function. Restitution is considered to be the major determinant of epithelial repair as function recovers...Full Text Available

UK PubMed Central (United Kingdom)

Acute inflammation is important for tissue repair; however, chronic inflammation contributes to neurodegeneration in Alzheimer’s disease (AD) and occurs when glial cells undergo prolonged...Full Text Available

UK PubMed Central (United Kingdom)

Oxidative stress occurs when the level of prooxidants exceeds the level of antioxidants in cells resulting in oxidation of cellular components and consequent loss of cellular function. Oxidative...Full Text Available

UK PubMed Central (United Kingdom)

We report on the presentation and management of a patient with herniation of the rectum following a coccygectomy. We used an abdominal approach and careful pelvic dissection to define the defect in...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Solving the maintenance and repair problems of electronic instruments, we have supported the research and development work, and reduced operation costs of the pilot plants in KAERI. In addition, we have imposed the maintainability of instruments to use effectively. 15 tabs., 14 figs., 14 refs. (Author) .new.

UK PubMed Central (United Kingdom)

All ceramic fixed partial dentures (FPD)s exhibit enhanced biocompatibility and esthetics as compared to metal-ceramic restorations. However, framework fractures are frequently reported especially when...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A publication on Norwegian gas and gas export. The content is wide spread from use of gas in daily life via sub sea pipeline repair systems to an overview over tomorrows gas fields. (AG)

UK PubMed Central (United Kingdom)

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N′-nitrosonornicotine (NNN) are tobacco-specific nitrosamines present in tobacco products and smoke. Both compounds...Full Text Available

UK PubMed Central (United Kingdom)

Human apurinic/apyrimidinic endonuclease (hApe1) encodes two important functional activities: an essential base excision repair (BER) activity and a redox activity that regulates expression...Full Text Available

UK PubMed Central (United Kingdom)

DNA double-strand breaks (DSBs) are generally accepted to be the most biologically significant lesion by which ionizing radiation causes cancer and hereditary disease. However, no information on the...Full Text Available

Science.gov (United States)

Sears for the Kenmore PRO to schedule a free repair. Consumers can continue to use the cooktop (top burners) and the broiler as well as any clock and/or timer functions. Consumer...

Medline Plus

... and at that point she had already failed physical therapy, which someone else had prescribed, and so ... MRI, we may try a brief course of physical therapy to see if they feel better, but ...

Energy Technology Data Exchange (ETDEWEB)

Short communication

UK PubMed Central (United Kingdom)

An 11-year-old mare presented 36 hours after foaling with a ruptured bladder. Uroperitoneum was diagnosed on ultrasound and from the creatinine concentration of the peritoneal fluid. Bladder endoscopy...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Anesthetic techniques vary widely in the endovascular repair of abdominal aortic aneurysms (EVAR). Previous studies have demonstrated the feasibility of using local anesthesia. However, the ideal anesthetic technique has not been determined. This study examines whether anesthesic technique influences the outcomes of EVAR. Data regarding demographics, risk factors, procedural characteristics, recovery characteristics, treatment complications, acute ( 0.05, ANOVA). From these results we concluded that EVAR with local anesthesia is a safe and efficacious method that may reduce recovery times and postoperative medical morbidity compared to use of genera1 or spinal/epidural anesthesia.

International Nuclear Information System (INIS)

The role of the HCR system in the repair of prelethal lesions induced by UV light, #gamma# radiation and alkylating agents was studied in the Bacillus subtilis SPP1 phage, its heat sensitive mutants (N3, N73 nad ts_1) and corresponding infectious DNA. The survival of phages and their transfecting DNA after treatment with UV light is substantially higher in hcr"+ cells than in hcr cells, the differences being more striking in intact phages than in their transfecting DNA's. Repair inhibitors reduce survival in hcr"+ cells: caffeine lowers the survival of UV-irradiated phage SPP1 in exponentially growing hcr"+ cells but has no effect on its survival in competent hcr"+ cells; acriflavin and ethidium bromide decrease the survival of the UV-irradiated SPP1 phage in both exponentially growing and competent hcr"+ cells to the level of survival observed in hcr cells; moreover, ethidium bromide lowers the number of infective centres in hcr"+ cells of the ...

Science.gov (United States)

Autoreactive cytotoxic CD8 T-cells (CTLs) play a key pathogenic role in the destruction of insulin-producing beta-cells resulting in type 1 diabetes. However, knowledge regarding their targets is limited, restricting the ability to monitor the course of the disease and immune interventions. In a multi-step discovery process to identify novel CTL epitopes in human preproinsulin (PPI), PPI was digested with purified human proteasomes, and resulting COOH-fragments aligned with algorithm-predicted HLA-binding peptides to yield nine potential HLA-A1, -A2, -A3 or -B7-restricted candidates. An UV-exchange method allowed the generation of a repertoire of multimers including low-affinity HLA-binding peptides. These were labeled with quantum dot-fluorochromes and encoded in a combinatorial fashion, allowing parallel and sensitive detection of specific, low-avidity T-cells. Significantly increased frequencies of T-cells against four novel PPI epitopes (PPI(4-13)/B7, PPI(29-38)/A2, PPI(76-84)/A3 ...

Science.gov (United States)

Porcine pancreatic lipase immobilized on celite particles has been employed as a catalyst for the esterification of dodecanol and decanoic acid in a predominantly organic system. Solvent influence on the equilibrium position and on the catalyst activity has been studied using 20 solvents, including aliphatic and aromatic hydrocarbons, ethers, ketones, nitro- and halogenated hydrocarbons, and esters. The equilibrium constant for esterification correlates well with the solubility of water in the organic solvent, which in turn shows a good relationship with a function of Guttman's donor number and the electron pair acceptance index number of the solvent. This may be rationalized in terms of the requirements for solvation of water and of the reactants. The catalyst activity, measured as the initial rate of the esterification reaction, is best correlated as a function of both n-octanol-water partition coefficient (log P) and either the electron pair acceptance index or ...

British Library Electronic Table of Contents (United Kingdom)

Glucagon plays critical roles in regulating glucose homeostasis, mainly by counteracting the effects of insulin. Consequently, the dysregulated glucagon secretion that is evident in type 2 diabetes has significant implications in the pathophysiology of the disease. Glucagon secretion from pancreatic -cells has been suggested to be modulated by blood glucose, signals from the nervous system and endocrine components. In addition to these regulators, intraislet factors acting in a paracrine manner from neighbouring -cells are emerging as central modulator(s) of -cell biology. One of the most important of these paracrine factors, insulin, modulates glucagon secretion. Indeed, the -cell-specific insulin receptor knockout (IRKO) mouse manifests hypersecretion of glucagon in the postprandial stag...

Energy Technology Data Exchange (ETDEWEB)

The overall objective of this project has been to develop immunochemical methods to quantitate unique DNA base damages in order to facilitate studies on radiation-induced damage production and repair. Specifically, we have been using antibodies raised to damaged bases to quantitate unique lesions in model systems in order to evaluate their potential biological consequences. Our approach has been to synthesize modified nucleotides or nucleosides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits or to prepare monoclonal antibodies. We have been studying damages that are stable radiolysis products found in X-irradiated DNA and thus of potential biological consequence. Our aim is to build an in vitro and in vivo data base on the interactions between model DNA lesions and such cellular enzymes as DNA polymerases and repair endonucleases. Initial studies have focused on pyrimidine ring saturation products (thymine ...

Energy Technology Data Exchange (ETDEWEB)

The Control Rod Drive(CRD) nozzles for PWR nuclear power plants(NPP) house the control rod drives. The number of nozzle penetrations range from the mid-30's to over 100 in each reactor head. The integrity of CRD nozzles is very important, because the primary pressure boundary is established with the J-groove weld joining the nozzle to the head clad surface. The Alloy 600 PWSC CRD nozzle leaks discovered in the fall of 2000 and spring of 2001 in several US plants. Therefore the NRC has recommended a more proactive effort by US utilities to inspect similarly susceptible nozzles in all US plants. The primary safety concern is circumferential cracks that can permit the nozzles to separate from the head at high velocity and produce a large-break leak in the reactor vessel. A secondary concern is head leakage from any through-wall cracks in the nozzle or J-groove weld area. Numerous inspection and repair tools have been developed to address CRD nozzle inspection ...

Energy Technology Data Exchange (ETDEWEB)

An industrial design of turbodrill with oil-filled gear reducer has been made and has passed comprehensive field tests. In its energy characteristics, durability and operating properties, it is acceptable for broad introduction into drilling practice. In all regions of drilling, the use of the reducer increases the drilling per drill bit, and with sufficient depth, the run velocity of drilling. In certain regions (for example, West Siberia) it is possible to increase the mechanical velocity by high torque at the reducer outlet. The inter-repair service life of the oil-filled reducers for West Siberia and Tatariya exceeds on the average 100 hours. For wells with high face temperatures (over 1502)C) it reaches 42.6 hours. Further increase in the service life is associated with an increase in the thermoresistance, primarily, of the lubricator assembly. The design of the oil-filled reducer makes it possible to repair it in the existing turbine ...

British Library Electronic Table of Contents (United Kingdom)

Individuals who use augmentative and alternative communication (AAC) depend on technology to meet their daily needs and form relationships. Speech generating devices (SGDs) are integral components of communication systems. Reliability of SGDs is critical for effective use in everyday life. This study examined the reliability of new SGDs and found that mean time to first failure was 42.7 (SD = 41.2) weeks and at least 40% required repairs within the first year of use. The components that most frequently broke down were touch screens, wiring, main boards, batteries, memory cards, and AC adaptors. The costs of repairing SGDs were analyzed. The clinical implications of device breakdown are identified for key stakeholders, including clients, families, service providers, funding agencies, and ma...

British Library Electronic Table of Contents (United Kingdom)

Purpose - To study the optimization of a randomized control problem in an M/G/1 queue in which a removable and unreliable server may provide two phases of heterogeneous service to arriving customers. Design/methodology/approach - Arriving customers follow a Poisson process and require the first essential service (FES). As soon as FES of a customer is completed, the customer may leave the system or opt for the second optional service (SOS). The service times of FES channel and SOS channel are assumed to be general distribution functions. The server requires a startup time with random length before starting service. When the server is working, he may meet unpredictable breakdowns but is immediately repaired. The inter-breakdown time and repair time of the removable server are exponentially r...

International Nuclear Information System (INIS)

The new Code Case to substitute the allowable crack angle for a circumferential surface crack in 'Rules on Fitness-for-Service (FFS)' published from The Japan Society of Mechanical Engineers (JSME). Until now, the angle of a circumferential surface crack was limited below 60deg. This is the limitation with consideration to the stability of the crack if the deep crack penetrates wall of the pipe. Therefore, a long crack (such like an SCC) was obliged to repair or replace even if it was shallow enough. Weld Overlay (WOL) repair in which strength of the original piping is ignored is also inapplicable for the same reason. In order to solve this irrationality, the new Code Case applying to the crack stability assessment when the crack angle exceeds 60deg was established, and allowable crack depth according to the crack angle were defined in it. (author)

Science.gov (United States)

PURPOSE: To determine the recommended dose of radiotherapy when combined with full-dose gemcitabine and erlotinib for unresected pancreas cancer. METHODS AND MATERIALS: Patients with unresected pancreatic cancer (Zubrod performance status 0-2) were eligible for the present study. Gemcitabine was given weekly for 7 weeks (1,000 mg/m(2)) with erlotinib daily for 8 weeks (100 mg). A final toxicity assessment was performed in Week 9. Radiotherapy (starting at 30 Gy in 2-Gy fractions, 5 d/wk) was given to the gross tumor plus a 1-cm margin starting with the first dose of gemcitabine. A standard 3 plus 3 dose escalation (an additional 4 Gy within 2 days for each dose level) was used, except for the starting dose level, which was scheduled to contain 6 patients. In general, Grade 3 or greater gastrointestinal toxicity was considered a dose-limiting toxicity, except for Grade 3 anorexia or Grade 3 fatigue alone. RESULTS: A total of 20 patients were treated (10 men and 10 ...

Science.gov (United States)

BackgroundDespite an ever-improving understanding of the molecular biology of cancer, the treatment of most cancers has not changed dramatically in the past three decades and drugs that do not discriminate between tumor cells and normal tissues remain the mainstays of anticancer therapy. Since Hsp90 is typically involved in cell proliferation and survival, this is thought to play a key role in cancer, and Hsp90 has attracted considerable interest in recent years as a potential therapeutic target.MethodsWe focused on the interaction of Hsp90 with its cofactor protein p60/Hop, and engineered a cell-permeable peptidomimetic, termed "hybrid Antp-TPR peptide", modeled on the binding interface between the molecular chaperone Hsp90 and the TPR2A domain of Hop.ResultsIt was demonstrated that this designed hybrid Antp-TPR peptide inhibited the interaction of Hsp90 with the TPR2A domain, inducing cell death of breast, pancreatic, renal, lung, prostate, and gastric cancer ...

Energy Technology Data Exchange (ETDEWEB)

Waste tank W-12 is a tank in the ORNL Low-Level Liquid Waste (LLLW) system that collected waste from Building 3525. Because of a leaking flange in the discharge line from W-12 to the evaporator service tank (W-22) and continual inleakage into the tank from an unknown source, W-12 was removed from service to comply with the Federal Facilities Agreement requirement. The initial response was to decontaminate the valve pit between tank W-12 and the evaporator service tank (W-22) to determine if personnel could enter the pit to attempt repair of the leaking flange. Preventing the spread of radioactive contamination from the pit to the environment and to other waste systems was of concern during the decontamination. The drain in the pit goes to the process waste system; therefore, if high-level liquid waste were generated during decontamination activities, it would have to be removed from the pit by means other than the available liquid waste connection. Remote ...

International Nuclear Information System (INIS)

A survey was conducted of experience with steam generator tubes at nuclear power stations during 1976. Failures were reported at 25 out of 68 water-cooled reactors. The causes of these failures and the repair and inspection procedures designed to cope with them are summarized. Examination of the data indicates that corrosion was the major cause of steam generator tube failures. Improvements are needed in steam generator design, condenser integrity and secondary water chemistry control. (author).

International Nuclear Information System (INIS)

The requirements are given as placed on the development, procurement, maintenance, and application of software for the creation or processing of data during the design, construction, operation, repair, maintenance and safety-related upgrading of nuclear power plants. The verification and validation processes are highlighted, and the requirements put on the software documentation are outlined. The general quality assurance principles applied to safety analyses are characterized. (J.B.). 1 ref.

Energy Technology Data Exchange (ETDEWEB)

This paper investigates the calculation of availability for parallel transmission lines (two or more) in the same tower or on the same right of way. As in many studies, the development of mathematical models is an important step. The models are justified using historical data and known characteristics of power system elements. A statistical method was used to generalize the failure rate and repair rate from real operating data. Application of the new model (which combines common-mode, simultaneous independent, and dependent outages) is discussed.

International Nuclear Information System (INIS)

The frequency of peripheral pulmonary artery stenosis in patients after surgical repair of tetralogy of Fallot (TOF) ranges from 20 to 40%. This can be either primary or secondary to the surgical intervention. The influence of resulting lung perfusion alterations on the life quality of patients is difficult to predict. The aim of this study was to compare the utility of the diagnostic procedures in this group of patients, with particular focus on lung perfusion scintigraphy. This study comprised 104 patients who underwent repair of TOF at ages from 5 months to 25 years. The patients have been followed up for from 4.2 to 25 years. On the basis of chest X-ray peripheral pulmonary artery stenosis was suspected in 11 patients, in 12 on the basis of echocardiography examination. Lung perfusion scintigraphy has been performed on 87 patients. The disturbances in lung perfusion (mostly in the left lung) were show by means of lung perfusion scintigraphy ...

UK PubMed Central (United Kingdom)

Ditercalinium, an antitumor bifunctional intercalator which forms a high affinity reversible complex with DNA, was found to be specifically cytotoxic for polA and lig7 E. coli strains. In the polA strain,...Full Text Available

International Nuclear Information System (INIS)

A report on the Canadian Nuclear Society Conference on robotics and remote handling in the nuclear industry, September 1984. Remote handling in reactor operations, particularly in the Candu reactors is discussed, and the costs and benefits of use of remote handling equipment are considered. Steam generator inspection and repair is an area in which practical application of robotic technology has made a major advance. (U.K.).

Energy Technology Data Exchange (ETDEWEB)

Due to the fast cooling of steam turbines, the shutdown time during maintenance or when repairing faults and damage can be shortened. This booklet describes various processes for cooling steam turbines. It is recommended that fast cooling should be planned in designing new plants and corresponding arrangements should be provided in the form of pipe connections and valves. (DG).

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The processes of lung growth, injury, and repair are characterized by alterations in fibroblast synthesis and interstitial distribution of extracellular matrix components. Transforming growth factor beta (TGF-beta), which is postulated to play a role in modulating lung repair, alters the distribution of several matrix components such as collagen and fibronectin. We studied the effect of TGF-beta on the synthesis and distribution of the various glycosaminoglycans (GAGs) and whether these effects may explain its role in lung repair. Human diploid lung fibroblasts (IMR-90) were exposed to various concentrations of TGF-beta (0-5 nM) for variable periods of time (0-18 h). Newly synthesized GAGs were labeled with either (3H)glucosamine or (35S)sulfate. Individual GAGs were separated by size exclusion chromatography after serial enzymatic and chemical digestions and quantitated using scintillation counting. There was a ...

International Nuclear Information System (INIS)

January, 1992, to October, 1995, sixty-four patients with advanced head and neck cancer underwent head and neck reconstructive surgery using myocutaneous or revascularized flaps; in the same period, all patients were consecutively examined with CT and MRI. Myocutaneous flaps were used in 26 patients: 12 flaps were tubular and 14 linear. Revascularized flaps were used in 38 patients: to repair a large defect in 26 patients (14 latissimus dorsi flaps and 12 temporal muscle flaps) and to repair an oral damage in 12 patients (5 revascularized radial and 7 jejunal flaps). CT and MR images of myocutaneous flaps showed the flaps as fatty areas, repairing large surgical defects, hypodense at CT and hyperintense at MRI, with no post-contrast enhancement. The appearance of revascularized flaps at CT and MRI depends on the characteristics of the structure used to repair the surgical defect: jejunal and radial ...

Energy Technology Data Exchange (ETDEWEB)

This paper presents a stochastic model and estimation procedure for analyzing the failure process of a repairable system. We consider repairable systems whose successive interfailure times reveal a significant dependence while showing an insignificant trend. Neither the renewal process nor the non-homogeneous Poisson process are adequate for modeling such failure processes. Especially when the interfailure times show a cyclic pattern, we may consider a switching of the regimes (states) governing the lifetime distribution of the system. We propose a Markov switching model describing the failure process for such a case. The model postulates that a finite number of states governs the distinct lifetime distributions, and the state makes transitions according to a discrete-time Markov chain. Each of the distinct lifetime distributions represents a failure type that may change after successive repairs. Our model generalizes the ...

Science.gov (United States)

... 2,000 230.102Tender plain bearing journal boxes: Failure to repair 1,000 1,500 230.103Tender roller bearing journal boxes: Failure to properly maintain 1,000 1,500 230.104Driving box shoes and wedges:...

International Nuclear Information System (INIS)

Radiation therapy has had a significant and an expanded role in the management of cancer of the pancreas during the last decade. In particular, for locally advanced disease, radiation therapy has improved the median survival of patients to 1 year. Intraoperative electron beam therapy has been applied to unresectable and resectable pancreatic cancer in an attempt to enhance local control of disease and to improve patient survival. This paper presents a survey of the role of radiation therapy in treatment of cancer of the pancreas, provides information on the radiobiological aspects of this treatment modality and details the physical and dosimetric characteristics of intraoperative radiation therapy with electrons. Presented are the design specifics of an applicator system, central axis beam data, applicator parameters, dose distribution data, shielding, treatment planning and means of verification. Emphasis is placed on the collaboration and cooperation necessary ...

Science.gov (United States)

The authors studied the resolution of racemic glycidol through esterification with butyric acid catalyzed by porcine pancreatic lipase in organic media. A screening of seven solvents (log P values between 0.49 and 3.0, P being the n-octanol-water partition coefficient of the solvent) showed that neither log P nor the logarithm of the molar solubility of water in the solvent provides good correlations between enantioselectivity and the properties of the organic media. Chloroform was one of the best solvents as regards the enantiometic purity (e.p.) of the ester produced. In this solvent, the optimum temperature for the reaction was determined to be 35C. The enzyme exhibited maximum activity at a water content of 13 [plus minus] 2% (w/w). The enantiomeric purity obtained was 83 [plus minus] 2% of (S)-glycidol butyrate and did not depend on the alcohol concentration or the enzyme water content for values of these parameters up to 200 mM and 25% (w/w), respectively. ...

Science.gov (United States)

Gallstone is a common disease with a 10% prevalence in the United States and Western Europe. However, it is only symptomatic in 20-30% of patients, with biliary pain "colic" being the most common symptom. Complications of asymptomatic gallstone disease are generally rare, with an incidence of <1 %/yr. The most common complications of gallstone disease are acute cholecystitis, acute pancreatitis, ascending cholangitis, and gangrenous gallbladder. Less frequent complications include Mirizzi syndrome, cholecystocholedochal fistula, and gallstone ileus. Mirizzi syndrome and cholecystocholedochal fistula are two manifestations of the same process that starts with impaction of a gallstone in the gallbladder neck that results in obstruction of the bile duct, causing jaundice. The gallstone may erode into the bile duct, causing cholecystocholedochal fistula. Gallstone ileus refers to small bowel obstruction resulting from the impaction of one or more gallstones after ...

Energy Technology Data Exchange (ETDEWEB)

A hose lining process, used widely for underground service structures, such as for city gas, and water and sewerage pipes, was adopted to repair interiors of underground wire raceways, and improvements were made for power cable pipe use, including long size construction, inner diameter assurance, and flame retardation. The sealing hose as a lining material consists of a fabric layer woven by warps of polybutylene terephthalate (PBT) and wefts of combined PBT fibers and glassfibers, the fabric being coated with polyurethane resin on one side. The other side of the fabric is coated with heat hardening resin made of epoxy resin as the main ingredient and aromatic amine as the hardening agent to assure close adhesion of the sealing hose onto the pipe interior. Mimic raceways were used to verify the lining material for its abrasion coefficient, mechanical strength, wear resistance, water cut-off performance, chemical resistance, and shape retention performance against ...

Energy Technology Data Exchange (ETDEWEB)

Chicken embryos were x-irradiated in ovo with 5-30 cGy (=priming dose) at the 13th-15th day of development. After 3-48 h, brain- and liver-cell suspensions were x-irradiated in vitro with (challenge) doses of 4-32 Gy. Significantly less radiation damage was observed when the radiation response was measured by scheduled DNA synthesis, nucleoid sedimentation and viscosity of alkaline cell lysates 12-36 h after the priming exposure. In vivo, pre-irradiation with 10 cGy enhanced regeneration as evidenced by the DNA content of chicken embryo brain and liver 24 h following a challenge dose of 4 Gy. From nucleoid sedimentation analyses in brain and liver cells immediately after irradiation with 16 Gy and after a 30-min repair period in the presence of aphidicolin, dideoxythymidine and 3-aminobenzamide or in the absence of these DNA repair inhibitors, it is concluded that a reduction of the initial radiation damage is the dominant mechanism of the ...

International Nuclear Information System (INIS)

Results of an evaluation of 18 different products that can be used as waterstops in hydraulic dams to minimize or eliminate leaks at construction joints, were discussed. The materials were tested for permeability and adherence at 23, 15 and 5 degrees C. A two-component polyurethane resin product was found to be the one that best fulfilled the evaluation criteria. It was also found that the successful injection of a borehole depends not only on selecting the product with the best performance characteristics, but also on the technique used. Hence the preparation of the resin and the pressure at which it is injected are important performance criteria. 5 refs., 6 photos, 4 figs.

International Nuclear Information System (INIS)

Results are presented applying an enteral nutrition by means of probes with Cosilat in complex therapy of patients with radiotherapeutic late effects of the colon. This nutrition was prescribed with the intention to gave the colon a functional recovery and to guarantee optimal conditions for repair of radiation injuries. Good results were seen in 27 of 28 patients (96.7%), the situation of one patient (3.3%) continued without any change. Cosilat has a high nutritive value, good organoleptic qualities and is well digested without any complications. (author).

Science.gov (United States)

The viability of osteocytes can be demonstrated in sawn decalcified sections of bone by their lactate dehydrogenase activity. In the cancellous bone of the femoral head, the proportion of lacunae containing viable osteocytes decreased from 88 +/- 7% (mean +/- SD) at 10-29 years to 58 +/- 12% (P Ultimate compressive strength did not correlate with osteocyte viability. In the femoral head there is gradual, age-related reduction in osteocyte viability that can be more pronounced in hip fracture. Osteocyte death may affect bone quality by impairing repair of fatigue damage. PMID:8275364

Energy Technology Data Exchange (ETDEWEB)

The method is used for repairing armored logging cables. It consists of preparing armor, subsequent connection of current-conducting strands and wires of the armor, and laying of the armor. Sections of connecting the wires of the armor of the lower and upper layers are scattered over the length of the fused section of the cable. In order to improve the fault strength of the cable, the junctions of connection of the armor wires are scattered among themselves at a distance determined by the Euler formula, and thermal tempering of the wire sections is carried out near these junctions, and then the fused section of the cable is reinforced.

Energy Technology Data Exchange (ETDEWEB)

Life management system is based on the valid nowadays in Estonian power plants regulation documentation. The system allows to estimate stress distribution in components, find computational assessment of cumulated creep damage, determine when and where it is necessary to cut off the particular number of microsamples or take replicas. Finally, the real metal condition may be assessed on the basis of metallographic specimen research and reasonable 3-R decision - run, repair, replacement - made on further component use. (orig.) 6 refs.

Energy Technology Data Exchange (ETDEWEB)

An apparatus is provided for rapidly restarting the flow of coolant through the cold electromagnetic shield of a superconducting rotor following a thermal transient episode. A vortex diode inhibits coolant flow in the undesirable reverse direction and encourages the reestablishment of a normal thermosyphon cooling loop flow quickly following the termination of a thermal transient such as that caused by transmission line faults. The present invention requires no moving parts and may therefore be permanently sealed in the superconducting rotor without risk of costly repair efforts caused by components failure.

Energy Technology Data Exchange (ETDEWEB)

The analgesic, dipyrone (1,phenyl-2,3-dimethyl-5-pyrazolone-4-methylamino methane sulphonate sodium), at 20 mM concentration, inhibited the rejoining of single-strand scissions in DNA of Escherichia coli B/r cells induced by 20 krad gamma-radiation. The chemical altered the cell membrane structure as evidenced from the uptake of acriflavin, the efflux of potassium ions from the bacterial cells and the inhibition of alkaline phosphatase-a cell membrane associated enzyme. (author). 18 refs., 6 figures.

International Nuclear Information System (INIS)

A statistical evaluation of rotor blade damage in axial steam turbines affords an insight into the extent of the repair costs incurred and reveals the types of defects and shortcomings which cause such damage. The great amount of rotor blade damage discovered during control inspections will surprise even many turbine experts. The statistical evaluation is followed by a review of the more frequent causes of damage and their characteristic features, illustrated on the basis of practical examples. This contribution is intended as an aid to both the manufacturers and operators of steam turbines in preventing the oft almost classic types of faults which constantly recur. (orig.).

Energy Technology Data Exchange (ETDEWEB)

sup(99m)Tc-MDP bone scintigraphy was performed on patients who received muscle-pedicle bone graft. In each of the bone head and the bone graft, a time-activity curve was obtained. In this muscle-pedicle bone graft, active revascularization and marked osteogenesis, which suggested rapid bone repairing, were observed. The bone scintigraphy was considered to be useful in observing the result of bone grafts, blood circulation, and time of bone fusion, and of value for early detection of secondary changes.

International Nuclear Information System (INIS)

The role of robotics and remote handling equipment in future nuclear power plant maintenance activities is discussed in the context of artificial intelligence applications. Special requirements manipulators, control systems, and man-machine interfaces for nuclear applications are noted. Tasks might include inspection with cameras, eddy current probes, and leak detectors; the collection of material samples; radiation monitoring; and the disassembly, repair and reassembly of a variety of system components. A robot with vision and force sensing and an intelligent control system that can access a knowledge base is schematically described. Recent advances in image interpretation systems are also discussed.

Energy Technology Data Exchange (ETDEWEB)

The Asejire dam at Ibadan, Nigeria was constructed in the late sixties for the purpose of providing water for the city of Ibadan (presently about 4,5 million inhabitants). It is located on the Oshun river approximately fifteen miles from the city. In 1982 cracks were observed on the wing walls and although these continued to develop, no attempt was made at that time to investigate their causes and no repair was carried out. In 1989 the SGI ENGINEERING Group of Geneva, Switzerland was appointed as the consultant for the complete refurbishment of the Asejire water scheme. The consortium Degremont-Poat-Clemessy was awarded the contract for the project. The African Development Bank and the Nigerian Government have provided the loan to finance the project.

Energy Technology Data Exchange (ETDEWEB)

As an alternative to surgery, endovascular therapy with stent grafts has become the second main treatment option for infrarenal abdominal aortic aneurysms. Unlike surgery, endovascular treatment with stent grafts is also applicable in patients unfit for open repair. Despite current improvements in endovascular repair devices, significant anatomic barriers still exclude this technique for a large number of patients. Computed tomography, magnetic resonance imaging, and ultrasound are essential for diagnostics, preintervention planning, and postintervention follow-up of abdominal aneurysms treated with stent grafts. This review covers etiology, pathology, and diagnostic aspects. Materials and methods for endovascular treatment of abdominal aortic aneurysms are presented in detail, and clinical results and complications are discussed. (orig.) [German] Die endovaskulaere Therapie des infrarenalen Bauchaortenaneurysmas hat sich als Alternative zur ...

Energy Technology Data Exchange (ETDEWEB)

We have compared the kinetics for repair of UV-induced cyclobutane pyrimidine dimers in the DNA of keratinocytes in human skin and in cell culture. A small area of the buttocks of volunteers was exposed to UVB-irradiation and biopsies were taken at various time intervals. Epidermal keratinocytes in culture from the same subjects were exposed to UVC with doses chosen to elicit comparable yields of dimers in cellular DNA. The initial density of pyrimidine dimers and the kinetics of their removal were assessed utilizing the dimer-specific T4 endonuclease V and sedimentation of the unlabeled DNA through alkaline sucrose gradients. The position of DNA in the gradients was determined using a monoclonal antibody against random sequences of single-stranded DNA in a sensitive immunoassay. The initial dimer frequency was 3.9-6.7 per 10(8) daltons DNA. About 40% of the dimers were removed within 1 h, 70% in 6 h, and 90% in 24 h for both in vivo and in vitro samples. The early ...

Energy Technology Data Exchange (ETDEWEB)

Radionuclide X-ray fluorescence analysis (RXRFA), as a non-destructive method, relatively simple and allowing measurements to be carried out in situ, is an excellent tool in research on various objects of art. A range of artefacts have been investigated by our laboratory, in part for the purposes of history of art and in part as a basis for restoration works - medieval frescoes in some Czech castles and churches, metal sculptures and objects of applied art, paints and inks of old manuscripts, paintings. Some of these are among the most valuable monuments in the Czech cultural heritage. The contribution of the results of the tests to the investigation of their 'life story' and, in some cases, to their conservation, is not negligible. Later additions and repairs can be recognised, and materials and technologies that are close to their historic counterparts can be used in restoration work.

International Nuclear Information System (INIS)

The effects of eight chemicals on the inactivation rate of ultraviolet radiation on the colony building capabilities of two strains of Saccharomyces cervisae - a wild type strain and a mutant deficient in excision repair - were studied. The insecticide methoxychlor, the herbicide 2,4-dichlorophenoxyacetic acid, the fungicide pentachlorophenol and its metabolite tetrachlorohydroquinone, as well as the chemicals acrylonitrile and 2,3-dichloro-1-propene have no significant impact on the effects of UV radiation in Saccharomyces cerevisae. Depending on the concentration, trichloroethylene increases the sensitivity to UV radiation. The herbicide paraquat provides efficient protection against UV radiation at concentrations where a toxic effect cannot be observed even without UV. The results were rather similar for both strains. (orig.).

British Library Electronic Table of Contents (United Kingdom)

For the safety of astronauts and to ensure the stability and integrity of the genome of microorganisms and plants used in bioregenerative life support systems, it is important to improve our knowledge of the combined action of (space) radiation and microgravity. The SOS-LUX-TOXICITY test, as part of the TRIPLE-LUX project (accepted for flight at Biolab in Columbus on the International Space Station, (ISS)), will provide an estimation of the health risk resulting from exposure of astronauts to the radiation environment of space in microgravity. The project will: (i) increase our knowledge of biological/health threatening action of space radiation and enzymatic DNA repair; (ii) uncover cellular mechanisms of synergistic interaction of microgravity and space radiation; (iii) provide specified...

International Nuclear Information System (INIS)

The Structural Aging (SAG) Program is carried out by the Oak Ridge National Laboratory (ORNL) under sponsorship of the United States Nuclear Regulatory Commission (USNRC). The Program has evolved from preliminary studies conducted to evaluate the long-term environmental challenges to light-water reactor safety-related concrete civil structures. An important conclusion of these studies was that a damage methodology, which can provide a quantitative measure of a concrete structure's durability with respect to potential future requirements, needs to be developed. Under the SAG Program, this issue is being addressed through: establishment of a structural materials information center, evaluation of structural component assessment and repair technologies, and development of a quantitative methodology for structural aging determinations. Progress to date of each of these activities is presented as well as future plans. 7 refs., 5 figs.

International Nuclear Information System (INIS)

We have at hand the tools for development of both a single amino acid substitution and a gene loss type assay for somatic cell mutations in human red cells. We are close to being able to assess the assays as possible means for screening the human population for individuals who may be a risk of acquiring abnormally high frequencies of mutant cells. The cause for such a high frequency of mutant cells could be a prior exposure of the individual to large amount of mutagen, or it could indicate a member of a vulnerable subpopulation that may have poor DNA repair systems. Either of these cases could well be an indication that the particular individual is at high risk that exposure to mutagens could lead to potential pathology. In the near future we expect to determine the reliability of the assays and to perform experiments to confirm the validity of flow cytometry in measuring real somatic mutagenic events that occur in vivo. (orig./AJ).

International Nuclear Information System (INIS)

The point at which the common final pathway for induction of cancer by chemical carcinogens and ionizing radiation has not been identified. Although common molecular targets are suggested by recent findings about the role of oncogenes, the mechanism by which the deposition of radiation energy and the formation of adducts or other DNA lesions induced by chemicals affects the changes in the relevant targets may be quite different. The damage to DNA that plays no part in the transformation events, but that influences the stability of the genome, and therefore, the probability of subsequent changes that influence tumorigenesis may be more readily induced by some agents than others. Similarly, the degree of cytotoxic effects that disrupt tissue integrity and increase the probability of expression of initiated cells may be dependent on the type of carcinogen. Also, evidence was presented that repair of the initial lesions could be demonstrated after exposure to low-LET ...

Energy Technology Data Exchange (ETDEWEB)

This paper describes the design and operating experience with a high performance control system tailored to the requirements of the SuperHILAC accelerator. A large number (20) of the latest 16-bit microcomputer boards are used in a parallel-distributed manner to get a high system bandwidth. Because of the high bandwidth, software costs and complexity are significantly reduced. The system by its very nature and design is easily upgraded and repaired. Dynamically assigned and labeled knobs, together with touch-panels, allow a flexible and efficient operator interface. An X-Y vector graphics system provides for display and labeling of real-time signals as well as general plotting functions. This control system allows attachment of a powerful auxiliary computer for scientific processing with access to accelerator parameters.

International Nuclear Information System (INIS)

We describe the analysis of forward mutations induced in the tetracycline resistance gene of the plasmid pBR322 by directing the reaction of the carcinogen N-acetoxy-N-2-acetylaminofluorene (N-AcO-AAF) to a small restriction fragment (BamHI, SalI) that is located in the proximal part of the antibiotic-resistance gene. Mutant plasmids obtained both in wild type and excision repair deficient (uvrA) bacterial cells are compared. Preliminary data showing the distribution of the -AAF adducts along this restriction fragments are discussed in relation to the observed spectrum of mutations. 20 references, 4 figures.

Energy Technology Data Exchange (ETDEWEB)

Langmuir-Blodgett (LB) preparations containing stacked monolayers of phospholipids or stearic acid were irradiated with UV light and the electric conductance perpendicular to the planes of the monolayers was measured. There was no observable change of conductance when LB preparations of stearic acid were irradiated. For LB preparations of phospholipids, a rise of conductance, dependent on dose rate, was observed, reaching an equilibrium level after a few hours. After irradiation the conductance fell with a temperature-dependent time constant, and eventually reached a final level a little above the initial value. A three-state model is proposed for the LB phospholipid preparations. This suggests that the absorption of one photon raises a molecule from the ground to an excited state; and the absorption of a second photon carries it into a damaged but repairable or metastable state. (author).

British Library Electronic Table of Contents (United Kingdom)

The recent breakthrough in the generation of rat embryonic stem cells (rESCs) opens the door to application of gene targeting to create models for the study of human diseases. In addition, the in vitro differentiation system from rESCs into derivatives of three germ layers will serve as a powerful tool and resource for the investigation of mammalian development, cell function, tissue repair, and drug discovery. However, these uses have been limited by the difficulty of in vitro differentiation. The aims of this study were to establish an in vitro differentiation system from rESCs and to investigate whether rESCs are capable of forming terminal-differentiated cardiomyocytes. Using newly established rESCs, we found that embryoid body (EB)-based method used in mouse ESC (mESC) differentiation...

Energy Technology Data Exchange (ETDEWEB)

Focused Ion Beam (FIB) repairs and modifications to integrated circuits have been somewhat limited in the past due to the physical limitations imposed by the nodes of interest being buried under metal layers, the need for multiple layers of FIB generated interconnects, and the like. With the advent of FIB deposited INSULATOR materials, integrated circuit modifications can now be much more complex. The two primary goals of this project were (1) to determine the appropriateness of FIB insulator deposition for aiding FIB connections to metal nodes buried under power busses, and (2) development of a technique to do this. The work presented in this paper includes the development and characterization phases of adding INSULATION DEPOSITION to a FEI 611 FIB system, the problems encountered, their work around, and the aforementioned application of this technology.

British Library Electronic Table of Contents (United Kingdom)

Ozone has in recent years been increasingly investigated for its potential use in the control of insect pests of stored cereals. Ozone is a powerful oxidizing agent that can react directly, or via production of reactive oxygen species, with proteins, DNA and double bonds of polyunsaturated fatty acids (PUFA). The aim of the present study was to investigate the mode of action in ozone toxicity using the red flour beetle, Tribolium castaneum (Herbst), as a relevant model. Transcription of focal genes thought to be involved in protection against ozone, and repair of cellular damage caused by ozone exposure, was studied together with the composition of storage lipid fatty acids and membrane phospholipid fatty acids in order to detect lipid peroxidation. Contrary to expectations, transcription ...

Energy Technology Data Exchange (ETDEWEB)

Contact scanner system in Wolsung NPP(model ESE-1565) is early `70 equipment so most of components are obsolete. To make 100% compatible PCBs for this system is main object of the study. Most of components used in the system are now not available in the electric market, furthermore original system maker no longer supplies spare parts. System supplier(AECL) quoted lots of money than general PCBs prices in case of spare PCBs are re-marked by canada maker. Contents and scope of the study are specifications research and system analysis, improvements of repairability and reliability, circuit design and simulations using computer aided tools(CAE), make arbitrary mechanical contacts signal generator for test system. Now the long-run test of home made PCBs are conducting at Wolsung NPP. (author). 20 refs., 42 figs.

International Nuclear Information System (INIS)

The possible long term effects of chronic radiation exposure have been studied. Rats were given tritiated drinking water (3#mu#Ci/ml) before pregnancy, during pregnancy and threafter, continuously through 5 generations. The brains were studied at 30 and 120 days postnatally. Significant decreases in weight, DNA and protein contents of specific parts of the brain were found, the most pronounced decreases being in the diencephalon. The decreases in protein content were more pronounced than the decreases in DNA content; the decreases were also more pronounced at 30 days than at 120 days, and more pronounced in the fifth generation than in previous generations. An attempt was made to explain these complex phenomena on the basis of known periods of proliferation of various brain cells, damage to mothers themselves in each generation, and damage and repair of nucleic acids caused by radioactivity.

International Nuclear Information System (INIS)

The author applies the GO methodology to reliability analysis of the offsite power supply system of Daya Bay NPP. The direct quantitative calculation formulas of the stable reliability target of the system with shared signals and the dynamic calculation formulas of the state probability for the unit with two states are derived. The method to solve the fault event sets of the system is also presented and all the fault event sets of the outer power supply system and their failure probability are obtained. The resumption reliability of the offsite power supply system after the stability failure of the power net is also calculated. The result shows that the GO methodology is very simple and useful in the stable and dynamic reliability analysis of the repairable system

Energy Technology Data Exchange (ETDEWEB)

We wanted to determine the technical and clinical efficacy of placing a self-expandable PTFE-covered nitinol stent for the management of inoperable malignant biliary obstruction. Thirty six patients with inoperable malignant biliary obstructions were treated by placement of self-expandable PTFE-covered nitinol stents (S and G Biotech Corporation, Seongnam, Korea). Clinical evaluation was done with assessment of the serum bilirubin and alkaline phosphatase levels, which were measured before and after stent placement within 1 week, at 1 month and at 3 months. The patient survival rate and stent patency rate were calculated with performing Kaplan-Meier survival analysis. Successful stent placement was achieved in all the patients without procedure-related complication. Pancreatitis as an early complication occurred in two cases. The serum bilirubin and alkaline phosphatase levels were significantly decreased after the procedure. During the follow-up, recurrent ...

Energy Technology Data Exchange (ETDEWEB)

To evaluate the feasibility and clinical effectiveness of using a polyurethane-covered expandable nitinol stent in the palliative treatment of malignant duodenal obstruction. Under fluoroscopic guidance, a polyurethane-covered expandable nitinol stent was placed in 12 consecutive patients with malignant duodenal obstructions. All presented with severe nausea and recurrent vomiting. The underlying causes of obstruction were duodenal carcinoma (n=4), pancreatic carcinoma (n=4), gall bladder carcinoma (n=2), distal CBD carcinoma (n=1), and uterine cervical carcinoma (n=1). The sites of obstruction were part I (n=1), part II (n=8), and III (n=3). Due to pre-existing jaundice, eight patients with part II obstructions underwent biliary decompression prior to stent placement. An introducer sheath with a 6-mm outer diameter and stents 16 mm in diameter were employed, and to place the stent, and after-loading technique was used. Stent placement was technically successful in ...

International Nuclear Information System (INIS)

Objective: Solid pseudopapillary tumor of the pancreas (SPTP tumor) is a rare pancreatic neoplasm with low malignant potential, which usually affects female patients in the second or third decades of life. It is a non-functional, slow-growing neoplasm that very often reaches considerable size before the first symptoms appear. Symptomatology is frequently related to tumor size. Surgical excision is usually curative in most cases. Infrequently the tumor can appear in male patients or in aged women, which can make the diagnosis more difficult. Some patients develop liver metastases in the follow-up that can be resected. Our purpose is to review the radiological and pathological findings of SPTP with emphasis on these infrequent cases. Subjects and methods: The medical records and radiological findings of patients who underwent surgery for SPTP between 2000 and 2005 were retrospectively reviewed. Study eligibility required that patients had undergone surgical resection ...

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CT of the gastrointestinal tract is commonly performed after administration of a high-density diluted iodinated oral contrast material. However, because if inadequate mixing of the contrast material with the gastrointestinal contents, pseudotumor and poor mucosal visualization are frequently shown on abdominal CT. To overcome these problem, 10% corn oil emulsion (COE) is tested as an alternative oral contrast agent in 40 patients. We analyse patients tolerance, gastric mucosal visualization and discrimination of pancreas from the duodenal C-loop to 10% COE in 40 patients compared with those obtained from 35 patients, who was received high-density diluted iodinated oral contrast agent (gastrografin). The results are as follows : 1. Patients' tolerance to 10% COE is similar to that to conventional oral contrast agent. 2. Image of the gastric mucosa from patients receiving 10% COE is superior to that receiving oral contrast agent. 3. The discrimination between ...

International Nuclear Information System (INIS)

Cockayne syndrome (CS) is a rare autosomal recessive disease, which shows diverse clinical symptoms such as photosensitivity, severe mental retardation and developmental defects. CS cells are hypersensitive to killing by ultraviolet (UV)-irradiation and defective in transcription-coupled repair. Two genetic complementation groups in CS (CS-A and CS-B) have been identified. We analyzed mutations of the CSA gene in 5 CS-A patients and identified 3 types of mutations. Four unrelated CS-A patients (CS2OS, CS2AW, Nps2 and CS2SE) had a deletion including exon 4, suggesting that there is a founder effect on the CSA mutation in Japanese CS-A patients. Patient CS2SE was a compound heterozygote for this deletion and an amino acid substitution at the 106th glutamine to proline (Q106P) in the WD-40 repeat motif of the CSA protein, which resulted in a defective nucleotide excision repair. Patient Mps1 had a large deletion in the upstream region including ...

International Nuclear Information System (INIS)

The first essential before embarking on the radiation-hardening of electrical insulation - mostly magnet coils - in any beam line application is to obtain a reliable estimate of the dose to the components. These are examples ( switchyards at SLAC and LAMPF) where the degree of hardness specified was much higher than was required. Although experience shows that the cost premium for substantial radiation - hardening is of the order of 10%, it has also become clear that well - designed beam line have negligible losses: hardening is required only in the vicinity of targets, collimators or other beam - intercepting devices. Where the beam is deliberately scraped, local shielding will minimize the associated radiation in the surroundings. Electron machines have their own special problems due to synchrotron radiation, so certainly coils and other electrical equipment should be kept away from the beam bend - plane. Because proton beams interact with thick targets in the meson factories, ...

Energy Technology Data Exchange (ETDEWEB)

The low budgets of local governments and Federal States in Germany as well as lack of financial means of renters delaying thorough modernisation of existing heating systems in residential and public buildings, novel heat supply and related customer services are emerging on the market. Heat supply companies and housing construction associations increasingly use modern electronics and telecommunication systems for heating system upgrading and reliable operation and maintenance. This option holds an enormous potential of saving money today and in the future. Installation of remote control and maintenance systems and the related telephone-based services offer fast repair and other services via electronic telecommunications systems, thus saving money and manpower for the repair services of heat suppliers or plumbers, or financial losses due to rents being docked for broken down heating systems. Such remote control and maintenance systems however ...

Energy Technology Data Exchange (ETDEWEB)

Owing to their key function in power production the technology of gas- and steam turbines has a very high importance. Gas turbines in particular have become much more efficient and show higher performance in cogeneration plants. The VDI group on materials engineering puts these issues at the centre of this report whose focus is on measures necessary to increase plant availability: damage analysis, materials optimisation, supervision of construction and repair. The report which looks at applications and practical experience is adressed to operators of gas-, steam-, and water turbine plants, manufacturers of turbines and their components as well as maintenance companies, experts and insurance engineers. (orig.) [German] Aufgrund ihrer Schluesselposition bei der Stromerzeugung kommen den Gas- und Dampfturbinen eine sehr hohe technische Bedeutung zu. Insbesondere die Gasturbine macht in den letzten Jahren eine rasante Entwicklung im Hinblick auf Erhoehung von ...

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Details of a novel intelligent pipeline anomaly location system were presented. The system was based on the emission and reception of extra low frequencies(ELF) disposed close to a pipeline that were then logged in the memory of an in-line inspection (ILI) tool to provide a more precise reference than time-based above-ground marker systems for the location of pipeline anomalies. The system consisted of 2 pairs of transmitter (TX) and receiving (RX) circuits working at low and varied frequencies. An additional module was installed in the front section of an ILI tool, which contained a frequency transmitter whose signals are transmitted through cabling to an external transmitter and retransmitted simultaneously to a receiver installed in the rear section of an additional module of the tool in order to guarantee that the signal recorded by the tool corresponded to the smart location system. The system was used to detect anomalies in a subsea pipeline near Rio de Janeiro which had limited ...

Energy Technology Data Exchange (ETDEWEB)

An x-ray zone plate was fabricated using the novel approach of focused ion beam (FIB) milling. The FIB technique was developed in recent years, it has been successfully used for transmission electron microscopy (TEM) sample preparation, lithographic mask repair, and failure analysis of semiconductor devices. During FIB milling, material is removed by the physical sputtering action of ion bombardment. The sputter yield is high enough to remove a substantial amount of material, therefore FIB can perform a direct patterning with submicron accuracy. The authors succeeded in fabricating an x-ray phase zone plate using the Micrion 9500HT FIB station, which has a 50 kV Ga{sup +} column. Circular Fresnel zones were milled in a 1.0-{micro}m-thick TaSiN film deposited on a silicon wafer. The outermost zone width of the zone plate is 170 nm at a radius of 60 {micro}m. An achieved aspect ratio was 6:1.

International Nuclear Information System (INIS)

The US Department of Energy has provided support to four universities and the Oak Ridge National Laboratory in order to pursue research leading to the development and deployment of an advanced robotic system capable of performing tasks that are hazardous to humans, that generate significant occupational radiation exposure, and/or whose execution times can be reduced if performed by an automated system. The goal is to develop a generation of advanced robotic systems capable of performing surveillance, maintenance, and repair tasks in nuclear facilities and other hazardous environments. This goal will be achieved through a team effort among the Universities of Florida, Michigan, Tennessee, Texas, and the Oak Ridge National Laboratory, and their industrial partners, Combustion Engineering, Martin Marietta Baltimore Aerospace, Odetics, Remotec, and Telerobotics International. Each of the universities and ORNL have ongoing activities and corresponding facilities in ...

International Nuclear Information System (INIS)

Purpose: To assess the prevalence, significance and practical value of two recently described CT signs of instable aneurysm: the crescent sign and the periluminal halo (a low-attenuating internal layer of the thrombus around the patent lumen). Material and methods: Among the CT examination performed in the last 5 years, they retrospectively selected the nonruptured aneurysms with a diameter exceeding 4 cm (no. = 93 average diameter 5.1 cm, unenhanced images in 28 cases and enhanced in 84) and the ruptured aneurysms (no. = 16, average diameter 6.7 cm, unenhanced images in 9 cases and enhanced in 9). They studied the prevalence of the crescent and halo sing, their relationship with the aneurysm diameter, and the effect of contrast enhancement. Results: The crescent sign was identified with a statistically significant prevalence in ruptured ( 37.5 % or cases) over asymptomatic aneurysms (5.5 %); the halo had the same frequency in the 2 groups (12.5 % and 9.5 %). Both signs were more ...

Energy Technology Data Exchange (ETDEWEB)

The structural acceptance criteria contained herein for the evaluation of existing underground double-shell waste storage tanks located at the Hanford Site is part of the Life Management/Aging Management Program of the Tank Waste Remediation System. The purpose of the overall life management program is to ensure that confinement of the waste is maintained over the required service life of the tanks. Characterization of the present condition of the tanks, understanding and characterization of potential degradation mechanisms, and development of tank structural acceptance criteria based on previous service and projected use are prerequisites to assessing tank integrity, to projecting the length of tank service, and to developing and applying prudent fixes or repairs. The criteria provided herein summarize the requirements for the analysis and structural qualification of the existing double-shell tanks for continued operation. Code reconciliation issues and material ...

International Nuclear Information System (INIS)

The Belgian Tihange 2 nuclear power plant went into commercial operation in 1983 producing a thermal power of 2785 MW. Since the commissioning of the plant the steam generators U-tubes have been affected by primary stress corrosion cracking. In order to avoid further degradation of the performance and an increase in repair costs, Electrabel, the owner of the plant, decided in 1997 to replace the 3 steam generators. This decision was supported by the feasibility study performed by Tractebel Energy Engineering which demonstrated that an increase of 10% of the initial power together with a fuel cycle length of 18 months was achieved. Tractebel Energy Engineering was entrusted by Electrabel as the owner's engineer to manage the project. This paper presents the role of Tractebel Energy Engineering in this project and the safety analysis program necessary to justify the new operation point and the fuel cycle extension to 18 months re-analysis of FSAR chapter 15 accidents ...

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Leak-before-break (LBB) analyses for circumferentially cracked pipes are currently being conducted in the nuclear industry to justify elimination of pipe whip restraints and jet impingement shields which are present because of the expected dynamic effects from pipe rupture. The application of the LBB methodology frequently requires calculation of leak rates. These leak rates depend on the crack-opening area of a through-wall crack in the pipe. In addition to LBB analyses, which assume a hypothetical flaw size, there is also interest in the integrity of actual leaking cracks corresponding to current leakage detection requirements in NRC Regulatory Guide 1.45, or for assessing temporary repair of Class 2 and 3 pipes that have leaks as are being evaluated in ASME Section 11. This study was requested by the NRC to review, evaluate, and refine current analytical models for crack-opening-area analyses of pipes with circumferential through-wall cracks. Twenty-five pipe ...

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The hydro-generators suffer during its operative useful life a combination of stresses of nature thermal, electric, mechanics and environmental. With the time, they are going losing the capacity to support those stresses and the power plants suffer, more and more frequently, undesirable stops for repair services and maintenance. In function of the high costs incurred with these stopped, the operation of the power plant can be economically impracticable. That unavailability of the generation for the electric system, it results in reduction of the reliability, burdening the politics of load ruling. The re-potentiation is a proposal that seeks to extend the useful life of hydro-generators, at the same time that it try to rescue the reliability and the readiness of the plant, with larger power. The power increase is usually made possible, or for the surplus of the hydro resources in excess, or for the reduction of the losses of all the components of the energy flow. ...

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This report presents the record of the workshop Water Treeing and Aging.'' The workshop was held in Phoenix, Arizona on December 9--11, 1990 and was sponsored by the Distribution Program of the Electrical Systems Division of the Electric Power Research Institute (EPRI). Attendance at the workshop was by invitation only. Twenty two attendees from seven countries, from universities, research organizations, electric utilities and polymeric materials suppliers took part in this workshop. The workshop was designed to assess progress in the understanding of water treeing phenomena and polymeric cable insulation aging since the last meeting of a similar forum of experts, which was organized by the Office of Exploratory Research of EPRI in December 1985. The objective of the present workshop was to assess progress and to provide direction for further studies in this field. The discussions covered a wide range of subjects including water tree structure, initiation, growth and ...

International Nuclear Information System (INIS)

The NATO Advanced Research Workshop on Nuclear Submarine Decommissioning and Related Problems was held in Moscow June 19--22, 1995. It was preceded by a visit to the Zvezdotchka Shipyard at Severodvinsk, a repair and maintenance yard for Russian nuclear submarines, for a subgroup of the workshop attendees. Most of the material in this paper is drawn directly form the workshop proceedings. Slightly less than 500 nuclear ships and submarines (the vast majority are submarines) have been constructed by the countries with nuclear navies. This includes approximately 250 by Russia, 195 by the United States, 23 by the United Kingdom, 11 by France and 6 by China. By the year 2000 it is expected that approximately one-half of these nuclear vessels will be removed from service and in various states of decommissioning. A newspaper account in June 1997 indicated that 156 Russian nuclear submarines had been removed from service. In August 1996 it was reported that 55 reactor ...

Science.gov (United States)

Prepared to make housing project managers, maintenance engineering staff, and designers and architects of HUD - assisted and HUD - insured housing projects and mobile home parks aware of their responsibilities under the Natural Gas Pipeline Safety Act, this handbook provides technical guidance for the reduction of gas leaks and the handling of gas leak incidents in residential areas. The hazards of natural gas, concern over gas safety in residential areas, applicable codes and standards, and sources of information and help are reviewed, along with maintenance and engineering considerations relating to gas pipe failures, the detection of gas leaks, appliance servicing, and pipe installation, repair, and replacement. Housing management considerations are also examined, with attention to recordkeeping and reporting, emergency contingency planning, tenant education, staff qualifications and training, and the development and use of a maintenance and operations manual. ...

International Nuclear Information System (INIS)

Full text: The focused ion beam (FIB) miller is becoming well established as a machine for the structural analysis of materials and for the rapid preparation of transmission electron microscope specimens. It has also been used for some time in the semiconducting materials industry for the analysis, repair and redesign of device materials. However, one emerging technique is the use of the FIB for micromachining. The FIB software can also be used to manufacture and machine components. This process can occur through converting software, typically in the form of bitmaps or TIF files, to proprietary 'stream' files. These files allow, often complex, patterns to be generated and milled into the specimen and thus the generation of micro-electromechanical systems. Frequently, this involves largely two-dimensional patterns and structures, however, more complex patterns and file types can be generated which allow, for example, device prototyping or the preparation of ...

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General trends in integrated circuit technology toward smaller device dimensions, lower thermal budgets, and simplified processing steps present severe physical and engineering challenges to ion implantation. These challenges, together with the need for physically based models at exceedingly small dimensions, are leading to a new level of understanding of fundamental defect science in Si. In this article, we review the current status and future trends in ion implantation of Si at low and high energies with particular emphasis on areas where recent advances have been made and where further understanding is needed. Particularly interesting are the emerging approaches to defect and dopant distribution modeling, transient enhanced diffusion, high energy implantation and defect accumulation, and metal impurity gettering. Developments in the use of ion beams for analysis indicate much progress has been made in one-dimensional analysis, but that severe challenges for two-dimensional ...

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Natural sunlight induces a genotoxic response in cultured CHO cells pre-treated with shale oil retort process water. Near ultraviolet light (NUV) component of the solar spectrum is the apparent radiation responsible for photoactivation. Cultured human skin fibroblasts are acutely sensitive to the genotoxic effects of photoactivated process water. The mutagenic potential of photoactivated process water in human cells is the same as that witnessed for an equivalent killing dose of the potent skin carcinogen FUV. DNA repair processes are involved in modulating genotoxic effects of this photo-induced process. The exact magnitude of the potential health-related and environmental risks resulting from photoactivation of retort process waters and other oil shale by-products is unassessed at this time. Our demonstration that a significant rate of mutation occurs in cultured human cells exposed to high dilutions of process waters and fluences of NUV comparable to that ...

International Nuclear Information System (INIS)

The goal of the Fifteenmile Creek Habitat Improvement project is to improve wild winter steelhead habitat in the Fifteenmile Creek Basin. This goal was addressed under the Columbia River Basin Fish and Wildlife Program, Measure 703 (c) (1) - Action Item 4.2. Construction of fish habitat structures was completed on approximately 3.5 miles of Eightmile Creek and on approximately 8.5 miles of Fifteenmile Creek. A total of 15,435 yds of rock was placed to improve rearing and spawning habitat, and to improve water quality and reduce siltation. Riparian protection fencing was completed on 1.8 miles of Dry Creek, approximately 1.75 miles on Eightmile Creek, and 4.75 miles on Fifteenmile Creek. Approximately 10 miles of stream will receive protection from the 8 miles of new fencing installed and 6.5 miles of abandoned fence repaired. Irrigation withdrawal screens were installed at six irrigation pump withdrawals. These screens functioned satisfactorily during the ...

International Nuclear Information System (INIS)

Reference is made to Cheng and Leblond (Amer. J. Anat.; 141:537 (1974)) who used tritiated thymidine to kill cells synthesising DNA in the crypts of the small intestine. Amongst their findings was that very low doses caused measurable cell killing and that the killing was not random throughout the crypt but occurred selectively at the crypt base where stem cells are presumably located. It is here reported that the presence of hypersensitive cells at the base of the crypts can be demonstrated after whole-body X- or gamma-irradiation, and the time sequence for the production and loss of the killed cells is described together with their dose-response relationship. The studies were conducted on mice. The data were expressed as surviving rather than killed cells, and it was established that the crypt are amongst the most sensitive of mammalian cells. The mechanism by which these sensitive cells are killed is not known, but DNA damage can be detected. The vital stem cells may lack any means ...

International Nuclear Information System (INIS)

This research report discusses the radiation hardening of a commercially available mobile robot, the REMOTEC ANDROS. This hardening effort is culminating in the availability of a megarad hardened mobile platform to access areas in nuclear facilities with extremely high levels of radiation (0.1 to 1 Mrad). These radiation levels may be encountered both during routine repair and monitoring activities and accident situations. The project has completed a phase-I U.S. Department of Energy Small Business Innovative Research contract and is now in a phase-II effort with completion scheduled in early 1995. The research involves the evaluation of the material and electrical components of an ANDROS robot to determine the anticipated radiation hardness of the current production version and evaluation of the components that must be replaced or modified to harden the system to higher radiation levels. The work being reported is based on an evaluation of the complete list of all ...

International Nuclear Information System (INIS)

Gas Distribution Companies have long paid great attention to improving the quality of gas supply service to the consumer. This has involved them in an on-going attempt to successfully define and establish a clear computer assisted replacement programme which, when drawn up on a reliability basis, may also prove cost effective. The reasons which drive any gas line replacement programme are mainly related to the necessity: to improve the gas network asset so as to face a striking expected growth in gas demand; to refurbish old distribution systems with the purpose not only to increase the reliability and continuity of gas supply but also to reduce the rate of maintenance costs due to frequent repair works; to prevent the possibility of massive replacement works for a progressing ageing of the network. This paper will present the computer assisted procedure being implemented by Italgas. It ranks well defined network areas which urgently need renewal and also have a ...

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The PMS2 gene encodes a protein that is involved in DNA mismatch repair and is mutated in a subset of patients with hereditary nonpolyposis colon cancer (HNPCC). The previously published PMS2 cDNA sequence lack an upstream in-frame stop codon preceding the presumptive initiating methionine. To evaluate the 5` terminus of the PMS2 coding region further, we isolated additional cDNA clones, RT-PCR products, and the corresponding 5` genomic segment of the PMS2 locus. The PMS2 gene transcripts were found to have heterogeneous but colinear 5` termini, one of which contained an in-frame termination codon preceding the initiating methionine. In addition, a novel gene encoding a 34.5-kDa polypeptide was found to initiate transcriptionally within PMS2 from the opposite strand. 23 refs., 5 figs., 2 tabs.

Energy Technology Data Exchange (ETDEWEB)

In this report, we outline the progress achieved in two distinct under the DOE-sponsored cross section project: the initial results obtained from the pulsed 14 MeV neutron facility, and a cooperative effort with Argonne National Laboratory in the measurement of fast neutron cross sections in yttrium. In the 14 MeV neutron laboratory, this year has seen the maturation of the project into one in which initial scattering measurements are now underway. We have improved the accelerator and ion source in several significant ways, so that neutron intensities have now been proven to be adequate for our series of elastic scattering angular distribution measurements outlined in our initial proposal of two years ago. We have successfully tested all components of the time-of-flight spectrometer and recorded initial neutron spectra from the ring targets that we have obtained for our first angular distribution measurements. Examples of the time-of-flight spectra that have been obtained are given ...

Energy Technology Data Exchange (ETDEWEB)

There are 760 feederpipes, which they are connected to inlet/outlet of the 380 pressure tube channels on the front of the calandria, in CANDU-type Reactor of Wolsung Nuclear Power Plant. As an ISI(In-Service Inspection) and PSI (Post-Service Inspection) requirements, maintenance activities of measuring the thickness of curvilinear part of feederpipe and inspecting the feederpipe support area within calandria are needed to ensure continued reliable operation of nuclear power plant. And ultrasonic probe is used to measure the thickness of curvilinear part of feederpipe, however workers are exposed to radioactivity irradiation during the measurement period. But, it is exposed to radioactivity irradiation during the measurement period. But, it is impossible to inspect feederpipe support area thoroughly because of narrow and confined accessibility, that is , an inspection space between the pressure tube channels is less than 100 mm and pipes in feederpipe support area are congested. And ...

Energy Technology Data Exchange (ETDEWEB)

Researches and production of radio-isotopes, radio-pharmaceuticals and cold kits are carried out in the Radio-isotope Production Facility (RIPF). Four concrete hot cells in Bank-1 are to produce the Ir-192 source for NDT. Eleven lead hot cells in Bank-2 are to produce Ho-166, Cr-51, P-32/33, Tc-99m, Lu-177, Sr-90/Y-90 and W-188/Re-188 for research purpose. Six lead hot cells in Bank-3 are used for the production of I-131 for diagnosis and therapy of cancer in the hospital. A hot cell in Bank-3 is also utilized for the research of I-125 and Br-82. Four lead hot cells in Bank-4 are utilized for the production of Mo-99/Tc-99m generators since 2005. The major systems including the Heat and Ventilated Air Conditioning (HVAC) system and the air cleaning system such as charcoal and HEPA filter trains to filter the radioactive contaminants are in operation. So are the systems such as power supply and distribution system, UPS, fire protection system, liquid radioactive waste collection systems. ...

Energy Technology Data Exchange (ETDEWEB)

Metagenomics projects based on shotgun sequencing of populations of micro-organisms yield insight into protein families. We used sequence similarity clustering to explore proteins with a comprehensive dataset consisting of sequences from available databases together with 6.12 million proteins predicted from an assembly of 7.7 million Global Ocean Sampling (GOS) sequences. The GOS dataset covers nearly all known prokaryotic protein families. A total of 3,995 medium- and large-sized clusters consisting of only GOS sequences are identified, out of which 1,700 have no detectable homology to known families. The GOS-only clusters contain a higher than expected proportion of sequences of viral origin, thus reflecting a poor sampling of viral diversity until now. Protein domain distributions in the GOS dataset and current protein databases show distinct biases. Several protein domains that were previously categorized as kingdom specific are shown to have GOS examples in other kingdoms. About ...

International Nuclear Information System (INIS)

An eddy current inspection has been applied for a pre-service and in-service examination of a steam generator in nuclear power plants. The experience from the inspection of steam generators showed that many plants had an excessive number of tubes with eddy current noise signals over several hundreds, which originated from manufacturing anomalies. The plants in U.S suffered significant downstream inspection costs, history reviews, and diagnostic testing because some signals resembled flaws and others masked a flaw. These lessens learned resulted in issuing the guidelines for steam generator tubing specifications and repair, in order to reduce the number of anomalous signals in the tubes and also to provide the requirement of a signal to noise ratio by applying a field type examination with bobbin coil eddy current probes at a manufacturing process. Besides the noise signals of a bobbin coil eddy current probe from manufacturing anomalies, the excessive background ...

International Nuclear Information System (INIS)

Steam generators for nuclear plants require access to the primary and secondary side for various inspection, cleaning and repair procedures and upon achieving access various inspection and cleaning tasks must be carried out. Steam generators currently at manufacture are therefore provided with; primary side access via the primary manways, steam drum access via the steam drum manway, U-bend region access via the secondary manway and drum-internals access passages, tubesheet secondary side access via tubesheet level inspection ports and tube support plate access via tube support level access ports. Many CANDU steam generators were built with only primary and drum manways and either no tubesheet ports or ports which were located ineffectively. The steam generators at Wolsong 1 were built with secondary side inspection ports that provided only limited access away from the no-tube-lane. In addition they have very difficult internal no-tube-lane access. Likewise, Units ...

International Nuclear Information System (INIS)

High quality "3"1P MR spectra (signal to noise ratio (S/N) approximately 18, 15 min acquisition for each spectrum) were consistently obtained with surface coils over a period of 6-week RT. Both transient and steady state alterations in metabolites in response to RT were found in this case. The transient changes occurred during the first 3 hr immediately after the 3rd fractionated RT, these changes include the transient elevation of the PCr resonance, a decrease in PDE and an increase in intracellular pH. The monitoring showed that the metabolites approached steady state approximately 2 hr after the fractionated radiation intervention, suggesting that in vivo MRS can be useful for studying the dynamics of tumor response to RT such as repair of potential lethal damage, growth delay, and reoxygenation etc. The steady-state MR spectra showed the net response to each intervention and can clinically be useful for predicting and measuring the result of the fractionated ...

Energy Technology Data Exchange (ETDEWEB)

Investigations show that nickel-based alloys (MAR M 247 CC, CM DS 247 L and CMSX-4) can be successfully brazened. Tensile tests of MAR M 247 CC samples brazened with foil brazing showed values comparable to those of the base material, some samples failed because of base material problems. Tests with powder mixes made up from commercial brazens and the base material CMSX-4 showed good wetting and a perfect microstructure similar to the base material. Tensile test values at RT (test temperature) and 850 degrees centigrade show pronounced scatter. Tensile tests at RT and 850 degrees centigrade are used to optimse brazing cycles for the types of brazen used (temperature, time). (orig.) [German] Die Untersuchungen haben gezeigt, dass es moeglich ist, Nickelbasislegierungen (MAR M 247 CC, CM DS 247 LC und CMSX-4) erfolgreich zu loeten. Die im Zugversuch erhaltenen Festigkeitswerte der mit folienfoermigen Lot geloeteten MAR M 247 CC Proben erreichten Werte nahe der Festigkeit des ...

Energy Technology Data Exchange (ETDEWEB)

The hydroelectric industry's recognition of the importance of avoiding unexpected failure, or forced outages, led to the development of probabilistic, or risk-based, methods in order to attempt to quantify exposures. Traditionally, such analysis has been carried out by qualitative assessments, relying on experience and sound engineering judgment to determine the optimum time to maintain, repair or replace a part or system. Depending on the nature of the problem, however, and the level of experience of those included in the decision making process, it is difficult to find a balance between acting proactively and accepting some amount of risk. The development of a practical means for establishing the probability of failure of any part or system, based on the determination of the statistical distribution of engineering properties such as acting stresses, is discussed. The capacity-demand analysis methodology, coupled with probablistic, risk-based analysis, ...

Energy Technology Data Exchange (ETDEWEB)

Historical information about the F-Area Railroad Crosstie Pile is limited. The unit is believed to have been a borrow area for earth fill that began receiving railroad crossties during the 1960s. The number of crossties at the unit began to increase significantly in 1984 when major repair of the SRS rail system was initiated. An estimated 100,000 used railroad crossties have accumulated at the unit since 1984. In an effort to determine the impact of the railroad crossties on the environment a total of 28 soil samples were collected from four test borings in March of 1991. Sample depths ranged from ground surface to 21.5 feet. Three of the borings were extended to the water table and groundwater samples were collected, one in an upgradient ``background`` area, and two downgradient from the unit. Few analytes were reported above detection limits. Test results are summarized in Section 4.0 and analytes not detected are summarized in Appendix A to this report. In three ...

Energy Technology Data Exchange (ETDEWEB)

This Site Maintenance Plan has been developed for Pacific Northwest Laboratory's (PNL) Nonnuclear Facilities. It is based on requirements specified by US Department of Energy (DOE) Order 4330.4A, Chapter I, Change No. 4. The objective of this maintenance plan is to provide baseline information for compliance to the DOE Order 4330.4A, to identify needed improvements, and to document the planned maintenance budget for Fiscal Year (FY) 1993 and to estimate maintenance budgets for FY 1994 and FY 1995 for all PNL facilities. Using the results of the self-assessment, PNL has selected 12 of the 36 elements of the Maintenance Program defined by DOE Order 4330.4A, Chapter I, for improvement. The elements selected for improvement are: Facility Condition Inspections; Work Request (Order) System; Formal Job Planning and Estimating; Work Performance (Time) Standards; Priority System; Maintenance Procedures and Other Work-Related Documents; Scheduling System; Post Maintenance Testing; ...

International Nuclear Information System (INIS)

The detection, in European steam generators, of intergranular stress corrosion cracking initiating from the primary side (PWSCC) and the somewhat similar detection of intergranular stress corrosion (IGSCC) and intergranular corrosion (IGA) initiated from the secondary side in Japanese steam generators has led to a growing awareness of the potential for such corrosion forms in United States PWR steam generators. What had been a minor occurrence at several units is now a cause of concern and repair measures at more than 30 sites in the United States, and in some cases, is the major cause of steam generator unavailability. The United States nuclear utilities and EPRI formed the first Steam Generator Owners' Group (SGOG) in 1977 in response to the prospect of continued denting corrosion. The occasional appearance of PWSCC, IGSCC and IGA in domestic steam generators was not a sufficient cause for initiating an extensive research program in SGOG I. In SGOG II ...

Energy Technology Data Exchange (ETDEWEB)

Aging degradation is a phenomenon we all experience throughout life, both on a personal basis and in business. Many industries have been successful in postponing the inevitable impact on their related systems and components through programs to maintain long-term reliability, maintainability and safety. However, this has not always been the case for nuclear power. While all power plants are experiencing the world trend of increasing operating costs with age, few (if any) have been able to fully define the parameters that solve the aging equation, particularly in relation to major components. Inspection and preventive maintenance have not been effective in predicting life-limiting degradation and failure. In CANDU nuclear plants, utilities are taking a comprehensive approach in dealing with the aging problem. Programs have been established to identify the current condition and degradation mechanisms of critical components, the failure of which would impact negatively on station ...

Energy Technology Data Exchange (ETDEWEB)

A case study of a hypothetical offshore production fixed leg platform facility is presented. The purpose of the case study is to demonstrate the advantages offered by modern, fuel efficient large gas turbines in central power generation service for offshore production. The case study was presented using the Rolls- Royce RB211 large gas turbine with facility production of approximately 240,000 BPD of oil and 540 MMSCFD of associated gas. The gas was subjected to three stages of separation for removal of hydrocarbon liquids and water. The liquids, natural gas, and crude oil were exported from the production platform to an onshore receiving terminal. Gas compression is the service that requires the greatest amount of power for any given production facility. For this case study, gas compression represented approximately 70 per cent of the power load with the remainder represented by the liquid export pumps (16 per cent), and by general utilities (14 per cent). The case study compared 2 ...

International Nuclear Information System (INIS)

Patients with Ewing's sarcoma who present with a central axis or proximal extremity primary and/or with metastatic disease have a poor prognosis despite aggressive combination chemotherapy and local irradiation. In this high risk group of patients, total body irradiation (TBI) has been proposed as a systemic adjuvant. To aid in the design of a clinical TBI protocol, the authors have studied in the in vitro radiation response of two established cell lines of Ewing's sarcoma and human bone marrow CFUc. The Ewing's lines showed a larger D_0 and anti-n compared to the bone marrow CFU. No repair of potentially lethal radiation damage (PLDR) was found after 4.5 Gy in plateau phase Ewing's sarcoma cells. A theoretical split dose survival curve for both the Ewing's sarcoma lines and human bone marrow CFUc using this TBI schedule shows a significantly lower surviving fraction (10"-"4-10"-"5) for the bone marrow CFUc. Based on these in vitro results, two 4.0 Gy fractions ...

International Nuclear Information System (INIS)

Coiling or infusion of embolic materials into a wide necked aneurysm can be performed with stenting. The purpose of our study is to assess the technical feasibility of aneurysm treatment with glue embolization after stenting. We used four Wallstents for surgically repairing eight canine carotid aneurysms. After confirmation of the aneurysms on the angiogram, we introduced a 6-7 F guiding catheter in order to deploy the stents. After stenting, we passed a microcatheter into the aneurysm lumen through the stent mesh. 28% glue was slowly injected until the glue cast completely filled the lumen. We evaluated the passage of a microcatheter through the stent meshwork, formation of the glue cast and the stents' ability to protection for any leakage of glue. The follow-up angiogram was obtained for two dogs, one to three times until 8 weeks, and then we sacrificed the dogs and performed pathologic examinations. Stenting was successful in all cases except one in which the ...

International Nuclear Information System (INIS)

Hepatic injury and regeneration of the liver are associated with activation of hepatic stellate cells (HSC). Fibroblast growth factors (FGFs) and their receptors are important regulators of repair in various tissues. HSC express FGFR3IIIc as well as FGFGR4 and different spliced FGFR1IIIc and FGFR2IIIc isoforms which differ in the presence or absence of the acid box and of the first Ig-like domain. Expression of FGF9, known to be capable to activate the HSC FGFR2/3-isoforms, was increased in HSC in liver slice cultures after exposition to carbon tetrachloride, as an acute liver injury model. FGF9 significantly stimulated 3-H thymidine incorporation of hepatocytes, but failed to induce DNA synthesis in HSC despite the fact that FGF9 induced a sustained activation of extracellular signal-related kinases (ERK) 1/2. FGF9 induced an increased phosphorylation of Tyr436 of the fibroblast growth factor receptor substrate (FRS) 2, while phosphorylation of Tyr196 which is ...

International Nuclear Information System (INIS)

In view of the anticipated increased use of atomic energy in industry, the possible long-term effects of chronic radiation exposure were studied in five generations of rats. Female rats (F_0) were given tritiated drinking water ("3HOH;3#mu#Ci/ml) from adolescence (60 days) until and throughout pregnancy. A separate study showed that the maximum radioactivity in the urine is reached in 30 days, and in the blood in 42 days. In the newborns, the highest specific activity was in the nucleic acid fraction, but total radioactivity was mainly due to the water (body fluids) compartment. No signs of radiation illness or increase in cataract formation in the mothers were observed. The food and water intake and body weight changes before pregnancy were normal. The course and the outcome of pregnancy were also normal. However, 60% of the newborns (F_1) exhibited hematomas, edemas, and subdural hemorrhages, which disappeared at 30 days of age. Bollod analysis of the F_1 offspring at various ages ...

International Nuclear Information System (INIS)

Female rats were given tritiated drinking water (3 microCi/ml) from 30 days before mating up to and throughout pregnancy. At this low dose, the course and the outcome of pregnancy were normal. The differences between newborn body and cerebral weights of the treated rats and those of control animals were on the borderline of significance. In contrast, cerebral DNA and cerebral protein were highly significantly lower. In 30-35% of the treated population the DNA and protein values were more than 2 standard deviations (SD) below the mean values for the control population. Thus the number of the progeny of the mothers exposed to tritiated water that were considered to have outstandingly low levels of DNA and protein was 14-17 times greater than in the control group. The irradiated population also had 3-5% of severely affected individuals with cerebral DNA and protein values more than 2 SD below the mean of the experimental population. However, even in this irradiated population, a certain ...

International Nuclear Information System (INIS)

Combination of radiotherapy and chemotherapy (CRC) is actually one important way of research in oncology. Theoretical advantages are: (1) Spatial cooperation; (2) Additivity, which is only obtained if the toxicity of each modality are different; (3) Supra-additivity, which needs a rigorous in vitro definition; the only way to prove it is to make an isobologram analysis. This model has however, some limitations: qualitative variable could not be used, results could be different, depending on the cell line and isoeffect chosen...In fact, a supra-additivity was only demonstrated for cis platinum and etoposide. Interactions mechanisms were: (1) at the molecular level, creation of new lesions or inhibition of radiation lesions repair; (2) At the cellular level, either cytokinetic cooperation with S-phase dependent drugs, or synchronization for the drugs which blocked the cells in M-phase; (3) At the tissular level, reoxygenation, cycle redistribution. In clinical ...

Energy Technology Data Exchange (ETDEWEB)

Since the first operation of nuclear steam generator early 1960s, its performance requirements have been met but the steam generator problems have been met but the steam generator problems have been major cause of reducing the operational reliability, plant safety and availability. U-tube assembly of steam generator forms the primary system pressure boundary of the plant and have experienced several types of tube degradation problems. Tube failure and leakage resulting from the degradation will cause radioactive contamination of secondary system by the primary coolant, and this may lead to unplanned plant outages and costly repair operations such as tube plugging or steam generator replacement. For the case of steam generators for heavy water reactors, e.g. Wolsong 2, 3, and 4 NPP, a high cost of heavy water will be imposed additionally. During the plant operation, steam generator tubes can potentially be subject to adverse environmental conditions which will cause ...

Science.gov (United States)

Medicinal plants play a major role in the life of Turkish people and of late medicinal plant usage has increased in many countries. Green plants in general contain mutagenic and carcinogenic substances, but there is little information about the biological activities of herbal medicine. In the present study, therefore, various Turkish medicinal herbs were investigated for their genotoxic potential in the Salmonella typhimurium microsomal activation assay and the alkaline single cell gel electrophoresis (COMET) assay. Extracts from these medicinal herbs and some fractions of these extracts were examined. The species investigated were Arctium minus, Ecballium elatterium, Momordica charantia, Plantago major, Urtica dioica, Viscum album, Salvia triloba, Euphorbia rigida, Stachys lavandulifolia, Acteoside, Abies nordmannia. They are used for various immune disorders and are applied either topically or taken orally as a herbal tea. Of the 19 samples of the extracts and fractions investigated, ...

International Nuclear Information System (INIS)

Ageing of nuclear power plants means evolution of material or equipment properties on one side, and evolution of personnel skill and procedure adequacy on the other side, both of which, after a certain time, may not be compatible with the required safety provisions, or with an economic operation of the plant. Repair or replacement of components, as well as change in service conditions for a better compatibility with component reduced capabilities can be used to mitigate ageing effects. The paper summarises the results of a study conducted in this field with the support of the European Commission. It presents: the synthesis of the work done under international auspices, and in the European context; the comparison of ageing management approaches used in several European countries with international recommendations; the summary of the various potential phenomena and their governing parameters, the methods of in-service ageing identification and possible mitigation ...

Energy Technology Data Exchange (ETDEWEB)

A Lawrence Livermore National Laboratory (LLNL) Management Pre-Start Review (MPR) Team was formed to independently verify the operational readiness of Building 368 (B368) Biosafety Level III (BSL-3) Facility to conduct research with biological pathogens and toxins including those considered Select Agents. Review objectives and criteria were developed from the DOE/NNSA and LLNL requirements. These were provided in the Implementation Plan for the Biosafety Level III (BSL-3) Facility Management Pre-Start Review (BSL-3 MPR) at Lawrence Livermore National Laboratory that was reviewed and approved by DOE/NNSA-LSO. The formal part of the LLNL MPR for the BSL-3 Facility was begun in August of 2005 but work on the MPR was stopped in October of 2005 due to the need for LLNL to reassess organizational and operational controls and respond to Centers for Disease Control and Prevention inquiries related to a shipping incident involving select agents. The MPR was restarted in mid-June of 2006. ...

International Nuclear Information System (INIS)

There are a total of nine operational nuclear plants in Spain totalling 7.350 MWe. These units produced 54.265 x 106 KWh in 1990, 36% of the total generation in Spain. Seven of these plants are of the PWR type. The first plant in operation was Jose Cabrera (ZORITA) in 1968, one loop Westinghouse plant with a model 24 Steam Generator. Due to the design margin and careful operation of the Steam Generator of this plant its performance have been very good, with only 5% tubes plugged after 23 years of operation. This is one of the few units in the world that remains in phosphate chemistry. During the period 1981-1985 a total of four units, two in Almaraz and two in Asco entered in operation. These three loop s Westinghouse units use model D-3 preheater Steam Generators. The poor design and manufacture of the Steam Generators of these units have caused a large number of problems: mechanical (Preheater and AVB's vibration), denting, and primary and secondary stress corrosion cracking. As a ...

Energy Technology Data Exchange (ETDEWEB)

Neutralizing an acidic fluid consists of adding a sodium hydroxide solution to neutralize the H group of acids, therefore increasing the pH. The injection of sodium hydroxide has to be continuous and at a proper depth inside the well to protect against the corrosion of casing and surface equipment. Neutralization is a common practice used in geothermal fields, such as at The Geysers in the US and Miravalles in Costa Rica-places where aggressive fluids cause problems for extracting and using geothermal fluids commercially. A zone surrounding wells H-4, H-16 and H-29 in the northern section of the Los Humeros, Pue., geothermal field, known as the Colapso Central, has shown evidence of aggressively acidic fluids. Several wells drilled in the area had to be repaired, thus plugging and isolating the deepest production zones. Well H-43 was drilled two years ago in the northern zone of the field, and even though it is not located in the aggressive-fluid zone, the well ...

Energy Technology Data Exchange (ETDEWEB)

Purpose of this work is to evaluate the effectiveness and role of CT in blunt diaphragmatic injuries by reviewing our 8-year experience. It is reviewed the preoperative CT findings of 35 patients with surgically confirmed diaphragmatic rupture. Surgical repair was performed in the acute setting (within 12 hours of trauma) in 22 cases, and late (8 months-5 years) in 13 cases. Twenty-eight patients (80%) were examined with conventional CT and 7 (20%) with Helical CT. Of the 13 patients examined long after trauma, the left hemi diaphragm was ruptured in 12 cases (with visceral herniation in 4), and the right hemi diaphragm in 1, with no herniation. The diaphragmatic rent was found in the dome (15 cases, 43%), muscolotendinous junction (11 cases, 31%), muscular portion (8 cases, 23%), and at the muscular attachments on the ribs (1 case, 3%). As for the site of diaphragmatic injury, CT never depicted the diaphragmatic rent in the dome and at the muscolotendinous ...