UK PubMed Central (United Kingdom)

Walled-off pancreatic necrosis (WOPN), formerly known as pancreatic abscess is a late complication of acute pancreatitis. It can be lethal, even though it is rare. This critical review provides an overview...Full Text Available

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The Zollinger-Ellison syndrome (ZES) is taken as an example of the diagnostic and therapeutic strategy in gastro-entero-pancreatic endocrine tumours, given the standard characteristics of this procedure, whatever the nature of the primitive tumour. Management of ZES includes: anatomical localization of gastrinoma and of possible metastases, in 60 % of cases this step conditioning therapeutic indications and chances of cure; search of a type 1-multiple endocrine neoplasia (MEN A), in 25 % of cases; therapeutic indications: ablative surgery with curative intent in case of gastrinoma and of resectable liver metastases, palliative treatment otherwise: anti-secretory drugs, somatostatin analogues, chemotherapy and interferon {alpha}; long-term follow-up of patients with resected tumour. At each step, somatostatin receptor scintigraphy with indium 111-pentetreotide does play a pivotal role. (author). 110 refs.

Science.gov (United States)

The most common causes of omental sac collections (OSC) are necrotic pancreatitis (90%) and pancreatic trauma (10%). Acute OSC is a form of local peritonitis in acute pancreatitis, subacute OSC are caused by internal pancreatic fistulas. The clinical and radiological signs, enzymatic activity of the exudate, morphological features of peritonitis were investigated. Treatment of acute OSC included conservative measures, of subacute OSC-surgical procedures. PMID:9163152

International Nuclear Information System (INIS)

Insulitis is considered the histopathological hallmark of type I diabetes. In the non-obese diabetic (NOD) mouse, diabetes has never been observed in the absence of insulitis. The in vivo detection of insulitis could be of relevance for early prediction of diabetes. As approximately 15% of islet-infiltrating lymphocytes express interleukin 2 receptors, the authors have labelled recombinant inter-leukin 2 with "1"2"3I and used this radiopharmaceutical to detect insulitis by gamma camera imaging. The authors studied 71 prediabetic NOD and 27 normal Balb/c mice. Labelled #alpha#-lactalbumin was used as the control protein. In the first set of experiments the tissue distribution of radiolabelled interleukin 2 in isolated organs from animals sacrificed at different time points was studied. Higher radioactivity was detected in the pancreas of NOD mice injected with labelled interleukin 2, as compared to NOD mice receiving labelled ...

UK PubMed Central (United Kingdom)

Pain caused by chronic pancreatitis is medically intractable and resistant to conventional interventional or surgical treatment. We report a case of spinal cord stimulation (SCS) for intractable pain...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundGastrointestinal stromal tumours (GIST) frequently occur in patients with neurofibromatosis type 1 (NF-1). It has been reported that GIST may co-exist with pancreatic endocrine...Full Text Available

UK PubMed Central (United Kingdom)

The virtual lack of well-characterized metastatic pancreatic cancer tissues for study has limited systematic studies of the metastatic process of this deadly disease. To address this important...Full Text Available

UK PubMed Central (United Kingdom)

Of 868 patients admitted with pancreatitis between 1971 and 1976, coexisting hyperbilirubinemia was noted in 125 (14%). The patient population was primarily composed of alcoholics (84%) with chronic...Full Text Available

UK PubMed Central (United Kingdom)

Recently, there has been significant progress in the development of genetically-engineered mouse (GEM) models. By introducing genetic alterations and/or signaling alterations of human pancreatic cancer...Full Text Available

UK PubMed Central (United Kingdom)

Pancreatic cysts are challenging lesions to diagnose and to treat. Determining which of the five most common diagnoses—pancreatic pseudocyst, serous cystic neoplasm (SCN), solid pseudopapillary...Full Text Available

UK PubMed Central (United Kingdom)

The purpose of this study was to determine the clinical significance of nodal micrometastasis detected by immunohistochemistry in patients that had undergone curative surgery for pancreatic cancer....Full Text Available

UK PubMed Central (United Kingdom)

A hitherto unrecognized variant of solid-pseudopapillary tumor (SPT) of the pancreas is reported. The tumor presented in the pancreatic tail of a 44-year-old female patient. It was a well-defined, solid...Full Text Available

UK PubMed Central (United Kingdom)

Autoimmune pancreatitis is frequently associated with elevated serum and tissue IgG4 levels in the adult population, but there are few reports of pediatric autoimmune pancreatitis, and even fewer reports...Full Text Available

UK PubMed Central (United Kingdom)

Background:Solid pseudopapillary tumor is a rare pancreatic neoplasm with uncertain to low malignant potential. This is an uncommon neoplasm with many pseudonyms, occurring...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The typical MRI features of the most common pancreatic diseases, such as pancreatitis and adenocarcinoma of the pancreas, have been established. However, even in these common pancreatic disorders, MRI correlation with the underlying pathology is limited for clinical reasons. We emphasize MR-pathological correlation of inflammatory and neoplastic pancreatic changes, including pancreatitis, adenocarcinoma, acinar cell carcinoma, rare cystic and solid pancreatic neoplasms, and islet cell tumors. By highlighting the correlation of key pathological features with MR findings, a better understanding of the MR appearance of pancreatic pathology can be provided. In addition, MRI may prove a powerful tool in detection and characterization of pancreatic tumors. (orig.) [Deutsch] Das MR-tomographische Erscheinungsbild von ...

British Library Electronic Table of Contents (United Kingdom)

Nonfunctioning pancreatic endocrine tumors (PETs) are rare and generally asymptomatic. A 68-year-old woman who had refused treatment for a pancreatic mass, revealed by ultrasonography to be 55 mm in diameter, was referred to us again 29 months later with jaundice. Investigations showed an 82-mm tumor in the head of pancreas, exposed from the papilla of Vater to the duodenal lumen. After biliary decompression and drainage, we performed pancreatoduodenectomy with resection of the portal vein and superior mesenteric vein, followed by reconstruction using a cylindrically customized autologous graft harvested from the right ovarian vein. The tumor was resected curatively. Microscopically, it consisted of trabecular and ribbon-like arrangement of neoplastic cells. Immunohistochemical staining wa...

UK PubMed Central (United Kingdom)

1. Proteolytic enzyme activities were examined in the pancreas of zinc-deficient and control rats. 2. No change was detected in trypsin-plus-chymotrypsin activity. 3. Carboxypeptidase activity was...Full Text Available

UK PubMed Central (United Kingdom)

We report here a case of a pathologically proven solitary fibrous tumor of the pancreas. A 54-year-old man was referred to our hospital for further evaluation of a pancreatic mass that was found incidentally....Full Text Available

UK PubMed Central (United Kingdom)

Menin, which is encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, is a tumor suppressor and transcriptional regulator. Menin controls proliferation and apoptosis of cells, especially pancreatic...Full Text Available

UK PubMed Central (United Kingdom)

Middle segment pancreatectomy (MSP) is a new operation where the advantages of parenchymal preservation are counterbalanced by a high postoperative complication rate and unease among surgeons with adopting...Full Text Available

UK PubMed Central (United Kingdom)

Pancreatic islet transplantation into the liver provides a possibility to treat selected patients with brittle type 1 diabetes mellitus. However, massive early β-cell death increases the number...Full Text Available

UK PubMed Central (United Kingdom)

In spite of their rarity, cystic neoplasms of the pancreas are characterized by existing or potential malignancy that cannot be ignored during decisive process with regard to the choice of treatment....Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Nerve growth factor (NGF), a survival factor for neurons enforces pain by sensitizing nociceptors. Also in the pancreas, NGF was associated with pain and it can stimulate the proliferation of pancreatic cancer cells. Hepatic stellate cells (HSC) respond to NGF with apoptosis. Transforming growth factor (TGF)-b, one of the strongest pro-fibrogenic activators of pancreatic stellate cells (PSC) induced NGF and its two receptors in an immortalized human cell line (ihPSC) and primary rat PSC (prPSC) as determined by RT-PCR, western blot, and immunofluorescence. In contrast to HSC, PSC expressed both NGF receptors, although p75NTR expression was weak in prPSC. In contrast to ihPSC TGF-b activated both Smad signaling cascades in prPSC. NGF secretion was diminished by the activin-like kinase (ALK)...

International Nuclear Information System (INIS)

The purpose was to study the toxicity of drugs known to generate free radicals on isolated pancreatic islets. The accumulattion of "8"6Rb"+ by mouse pancreatic islets was measured in vitro. Exposing the islets to 6-hydroxydopamine, minhydrin, or phenazine methosulphate + NADH inhibited the Rb"+ uptake, whereas paraquat or acetylphenylhydrazine had no effect. This effect of 6-hydroxydopamine was prevented by either of the hydroxyl radical scavengers, sodium benzoate and mannitol, but not by the non-scavenger,urea; ninhydrin was partially protected against by mannitol but not by benzoate. Protection against 6-hydroxydopamine was also afforded by D-glucose but not by L-glucose or 3-O-methyl-D-glucose; none of the sugars protected against ninhydrin. In damaging islet beta-cells and in being protected against by D-glucose, 6-hydroxydopamine closely resembles the diabetogenic drug, alloxan. It is suggested that protection against alloxan may involve ...

International Nuclear Information System (INIS)

Strain embrittlement in Ti base alloys during tensile testing was investigated. Results show that in an #alpha#-#beta# titanium alloy the local activity of H in alpha phase (#alpha#/sub H//sup #alpha#) increases and activity of H in beta phase (#alpha#/sub H//sup #beta#) decreases as the equiaxed #alpha# particle size decreases at constant volume fraction of phases. Thus with decreasing particle size there would be a tendency for H to move from #alpha# to #beta#, decreasing the H content of #alpha#. Also whether H tended to move from #beta# to #alpha# or from #alpha# interiors to the #alpha#-#beta# interface this tendency would be reduced by surface tension effects, making the alloy less susceptible to embrittlement.

International Nuclear Information System (INIS)

The emission lines H#alpha#, H#beta#+[OIII], and L#alpha# have been observed in the high-redshift quasar 1225+31. The ratios of line intensities in 1225+31 are found to be L#alpha#/H#alpha#approx.0.8, H#alpha#/(H#beta#+[OIII]) approx.4, and 4alpha#/H#beta#<10. The observed value of L#alpha#/H#alpha# agrees well with the ratio derived by Baldwin on the basis of a composite quasar spectrum, and with direct determination of this ratio in 3C 273 and PKS 0237--23. The ratio H#alpha#/H#beta# is in the range of values found for a sample of low-redshift quasars by Baldwin. The low value for the L#alpha#/H#alpha# ratio cannot be reasonably explained by foreground extinction between the Sun and 1225+31.

International Nuclear Information System (INIS)

... alpha reactions internal conversion iridium 187 iridium 188 iridium 189 isomeric

UK PubMed Central (United Kingdom)

Previous studies using in vitro cell culture systems have shown the role of the dynamin-related GTPase Opa1 in apoptosis prevention and mitochondrial DNA (mtDNA) maintenance. However, it remains to...Full Text Available

UK PubMed Central (United Kingdom)

Background/AimsAlthough endoscopic ultrasound guided fine needle aspiration (EUS-FNA) has been introduced and its use has been increasing in Korea, there have not been many reports...Full Text Available

UK PubMed Central (United Kingdom)

We have identified another Drosophila GTP-binding protein (G protein) alpha subunit, dGq alpha-3. Transcripts encoding dGq alpha-3 are derived from alternative splicing of the dGq alpha locus previously...Full Text Available

International Nuclear Information System (INIS)

A series of #alpha#-sialon (#alpha#') compositions containing mixed stabilising cations were prepared, by introducing additional CaO to a basic Sm #alpha#-sialon compositions. The thermal stability of these Sm-Ca-containing #alpha#-sialon phases was investigated using XRD, SEM and EDXS techniques. It was found that the addition of calcium into the Sm #alpha#-sialon systems greatly improved the stability of the #alpha#-sialon phases. Calcium was found to be incorporated into the #alpha#-sialon structure, coexistent with the samarium, and partitioning of the calcium and samarium was observed between the #alpha#' phase and grain boundary phases. This indicates a technique which may be used to improve the thermal stability of the #alpha#' phase while maintaining good refractory phases at the sialon grain ...

Energy Technology Data Exchange (ETDEWEB)

Long-Range Alpha Detector (LRAD) systems are designed to monitor alpha contamination by measuring the number of ions in the air. Alpha particles are a form of ionizing radiation and a typical 5-MeV alpha particle will create about 150,000 ion pairs in air. Field tests at various DOE sites have shown that LRAD Surface Soil Monitors (SSM), Sample Monitors, and Object Monitors are faster and more sensitive than traditional alpha detectors for measuring alpha contamination. This paper discusses the various applications of LRAD technology to low-level radioactive waste management.

International Nuclear Information System (INIS)

The formation of #alpha#'-sialon using Li as a modifying cation was investigated. The effects of the Li content, firing temperatures and Si/Al ratios on #alpha#'- yield were studied. The results indicated that at lower sintering temperatures the stabilisation of #alpha#'-sialons was obtained but the high weight losses of Li at higher temperatures limited the stabilisation. Increased ''Al'' content in the compositions resulted in an increase in the stability of Li-#alpha#'-sialon at higher temperatures, by the formation of a liquid phase which retains Li in the system. (orig.).

Energy Technology Data Exchange (ETDEWEB)

Purpose of this item is to report the CT patterns of pancreatic mesenchymal lesions and to investigate the capabilities and limitations of this technique in terms of characterization. In selected cases, CT can provide virtually diagnostic information (lipoma and teratoma), or at least highly suggestive findings (NHL, plexiform neurofibroma, lymphangioma). Moreover, knowledge of the variable morphostructural patterns of mesenchymal hisototypes (SCH, Sarcoma etc.) permits to include them in the differential diagnosis of pancreatic masses. [Italian] Scopo di questo rapporto e' descrivere gli aspetti semeiologici dei tumori mesenchimali del pancreas con la TC verificandone le possibilita e i limiti per la caratterizzazione. Pur nella rarita' dei reperti considerati, la TC puo' consentire l'effettiva caratterizzazione in alcuni casi (lipoma, neurofibroma plessiforme, linfangioma) o includere anche istotipi meno ...

Science.gov (United States)

The results of a study of the expression of embryonic hemoglobin genes in mice which show an imbalance of alpha and non-alpha chain synthesis are reported. (ACR)

Energy Technology Data Exchange (ETDEWEB)

We have studied the impact of overexpression of an intracellular signaling protein, integrin-linked kinase (ILK), on the survival and function of encapsulated islet tissue used for the treatment of type 1 diabetes. The dimensions of the encapsulated tissue can impact the stresses placed on the tissue and ILK overexpression shows the ability to extend function of dissociated cells as well as intact islets. These results suggest that lost cell-extracellular matrix interactions in cell encapsulation systems can lead to decreased insulin secretion and ILK signaling is a target to overcome this phenomenon. (communication)

International Nuclear Information System (INIS)

... alpha particles beta particles gamma radiation lead hot cells bricks shielding

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared

International Nuclear Information System (INIS)

Published in summary form only. 6 Refs.

Science.gov (United States)

... Accession Number : ADD120492. Title : Environmental Cracking of the Alpha-Beta Titanium Alloy, Ti-6Al-6V-2Sn,. Corporate ...

UK PubMed Central (United Kingdom)

Alpha-toxin, the major cytotoxic agent elaborated by Staphylococcus aureus, was the first bacterial exotoxin to be identified as a pore former. The protein is secreted as a single-chain, water-soluble...Full Text Available

UK PubMed Central (United Kingdom)

Abnormalities of dystrophin, the sarcoglycans, and laminin alpha2 are responsible for a subset of the muscular dystrophies. In this study we aim to characterise the nature and frequency of abnormalities...Full Text Available

International Nuclear Information System (INIS)

The Feynman-#alpha# method was applied to measurement of reactivity and the ability of this method for a real-time reactivity monitoring system was assessed. In the experiment, all measured data by BF_3 detectors were stored in a multi-channel scaler controlled by a personal computer, and they were analyzed to obtain prompt neutron decay constant (#alpha#) and reactivity with consideration of dead time of detector. It was found that #alpha# could be obtained almost in a real-time even for both positive and negative reactivities by the present experimental technique. (author).

International Nuclear Information System (INIS)

(1975). Netherlands Goos, HJTh. Rijksuniversiteit Utrecht (Netherlands).

UK PubMed Central (United Kingdom)

Tumor necrosis factor alpha (TNF-alpha) plays a central role in activation of first-line defenses of a host against foreign organisms. To determine whether Brucella infection modulated TNF-alpha production,...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Current applications of ..cap alpha..-particle spectrometry in post-irradiation research and reprocessing are reviewed. Implementation of procedures and techniques described in the literature to the particular samples at S.C.K./C.E.N. often results in a combined radiochemical method where ..cap alpha..-particle spectrometry is used to complement or enforce results obtained by other methods. Typical cases are reported and results obtained by different methods are compared to the results obtained by ..cap alpha..-particle spectrometry.

International Nuclear Information System (INIS)

In connection with the different cyclical strengths of the two-phase (#alpha# + #beta#) titanium alloy in the case of the acicular and rounded formations of the #alpha#-phase, we have studied, employing the X-ray diffraction method, the phase composition of the alloy and the influence of heat treatment upon it. Using the method of electronic fractography, we examined the fractures in samples destroyed by the asymmetric twisting, in order to find out why the durability of the alloy is dependent upon the #alpha# - phase structure. It has been found that in the BT22 alloy, the decay the #beta#-phase may proceed in two ways; either with the formation of the martensite #alpha#'-phase of the acicular shape or with the separation of the non-martensite round-shaped #alpha#-phase. The character of the phase transformations #beta# - #alpha# or ...

International Nuclear Information System (INIS)

The interaction between a lower hybrid wave and a fusion alpha particle displaces the alpha particle simultaneously in space and energy. This results in coupled diffusion. Diffusion of alphas down the density gradient could lead to their transferring energy to the wave. This could, in turn, put energy into current drive. Here we calculate numerical solutions for the alpha energy transfer and study a range of conditions that are favourable for wave amplification from alpha energy. We find that it is possible for fusion alpha particles to transfer a large fraction of their energy to the lower hybrid wave. The numerical calculation shows that the net energy transfer is not sensitive to the value of the diffusion coefficient over a wide range of practical values. An extension of this idea, the use of a lossy boundary to enhance the energy transfer, is investigated. ...

International Nuclear Information System (INIS)

The experiments show that the fluence threshold of 316L SS irradiated by 1.8 MeV alpha particle is between (0.8655-1.3457) x 10"1"8 #alpha#/cm"2, and the threshold decreases in the 1.5 MeV and 1.0 MeV alpha particle irradiation. For the solid solution samples irradiated by 1.5 MeV alpha particle, the threshold is below 0.5595 x 10"1"8#alpha#/cm"2, and for the 20% cold-worked sample, the threshold is between (0.8595-0.5063) x 10"1"8 #alpha#/cm"2. In 1.0 MeV alpha particle irradiation, the threshold for the solid solution sample and 20% cold-worked sample is between (0.3073-0.1024) x 10"1"8 #alpha#/cm"2 and (0.4108-0.3063) x 10"1"8 #alpha#/cm"2 respectively. The difference of threshold of the two kinds of samples shows that the 20% cold-working can influence the occurrence of blistering

International Nuclear Information System (INIS)

Phase transformations occuring during cold deformation in hardened #alpha#+#beta# titanium alloy of the Ti-Al-Mo-Zr-Sn-Si system with 10% summary content of alloying elements are studied by X-ray diffraction analysis. Two stages of trapsformation of metastable #alpha#''-phase are found. A conclusiop is made that ability of the alloy containing #alpha#''-phase to cold deformation is determined by the presence of favourable texture, by high degree of metastability and by volume portion of #alpha#''-phase in the alloy structure.

International Nuclear Information System (INIS)

In the case of inelastic scattering of alpha particles to the 3"+ state, the averaged angular distributions show a characteristic shape, corresponding to the excitation of such an unnatural parity state by alpha particles in the compound nucleus process. The modified Hauser-Feshbach cross-section calculations give a good description of the averaged distributions for the alpha particle scattering to the 3"+ state and the compound nucleus parameters could be extracted. The calculations of the compounds nucleus contributions to the other states in the case of 24 MeV alpha particle scattering from "2"8Si show that this contribution is not negligible and in the case of the scattering to the 4"+ state seems to be dominant. (Z.M.).

International Nuclear Information System (INIS)

Both microstructural graded and homogenous single-phase #alpha#-Sialon is obtained from Si_3N_4 powder for a broad range of compositions of practical interest. Elongated grains of #alpha#-Sialon could be developed in the monophase material by controlled mechanism of nucleation and growth. Tailoring of microstructure was realized through slow transformation reaction from Si_3N_4 to #alpha#-Sialon at lower temperature than sintering temperature when the composition is near the #alpha#-Sialon phase boundary. The mechanical properties are strongly correlated with the microstructure and are enhanced greatly in the optimized Sialon composition. (author)

International Nuclear Information System (INIS)

The "7Be(#alpha#,#gamma#)"1"1C and "7Li(#alpha#,#gamma#)"1"1B reactions are investigated in the three-cluster Generator Coordinate Method. The microscopic wave functions are described from #alpha# and "3He ("3H) clusters, with two coupling modes: #alpha#+"7Be ("7Li) and "3He ("3H)+"8Be. Different internal states of "7Be ("7Li) and "8Be are taken into account. The model is tested on "1"1C and "1"1B spectroscopic properties, which agree fairly well with experiment. We suggest that, in both nuclei, the (3)/(2)"- and (5)/(2)"- states located close to the #alpha#+"7Be ("7Li) threshold, are intruder states. The "7Be(#alpha#,#gamma#)"1"1C and "7Li(#alpha#,#gamma#)"1"1B reaction rates are calculated for temperatures up to 10"9 K. A strong enhancement is found with respect to the reaction rates currently used in astrophysical calculations. ((orig.)).

International Nuclear Information System (INIS)

Ca #alpha#-sialon is a high hardness material that exhibits in-situ growth of elongated grains during pressureless sintering. This potentially gives the material very good fracture toughness. This paper examined the effects of a number of variables on microstructural development during sintering. The effect of composition was investigated by studying seven different compositions. Densification was seen to be hindered in compositions that produced only small quantities of liquid phase during sintering. Elongated #alpha#-sialon was observed in all the compositions. It was in combination with equiaxed #alpha#--sialon in low liquid compositions, but only elongated #alpha#-sialon was present in the liquid rich compositions. The effects of using P-Si_3N_4 instead of #alpha#-Si_3N_4 starting powders were also examined. Compositions using only #alpha#-S_3N_4 and those ...

Energy Technology Data Exchange (ETDEWEB)

An /alpha//sub 2/-adrenergic receptor subtype has been cloned from a human kidney cDNA library using the gene for the human platelet /alpha//sub 2/-adrenergic receptor as a probe. The deduced amino acid sequence resembles the human platelet /alpha//sub 2/-adrenergic receptor and is consistent with the structure of other members of he family of guanine nucleotide-binding protein-coupled receptors. The cDNA was expressed in a mammalian cell line (COS-7), and the /alpha//sub 2/-adrenergic ligand (/sup 3/H)rauwolscine was bound. Competition curve analysis with a variety of adrenergic ligands suggests that this cDNA clone represents the /alpha//sub 2/B-adrenergic receptor. The gene for this receptor is on human chromosome 4, whereas the gene for the human platelet /alpha//sub 2/-adrenergic receptor (/alpha//sub 2/A) lies on chromosome 10. This ...

International Nuclear Information System (INIS)

The sequence segment 181-200 of the Torpedo nicotinic acetylcholine receptor (nAChR) #alpha#subunit forms a binding site for #alpha#-bungarotoxin (#alpha#-BTX). Synthetic peptides corresponding to the homologous sequences of human, calf, mouse, chicken, frog, and cobra muscle nAChR #alpha#1 subunits were tested for their ability to bind "1"2"5I-#alpha#-BTX, and differences in #alpha#-BTX affinity were determined by using solution (IC_5_0s) and solid-phase (K_ds) assays. Panels of overlapping peptides corresponding to the complete #alpha#1 subunit of mouse and human were also tested for #alpha#-BTX binding, but other sequence segments forming the #alpha#-BTX site were not consistently detectable. The role of a putative vicinal disulfide bound between Cys-192 and -193, relative to the Torpedo sequence, ...

Energy Technology Data Exchange (ETDEWEB)

The authors have cloned a full-length putative rat pancreatic lysophospholipase cDNA by an improved mRNA isolation method and cDNA cloning strategy using (/sup 32/P)-labelled nucleotides. These new methods allow the construction of a cDNA library from the adult rat pancreas in which the majority of recombinant clones contained complete sequences for the corresponding mRNAs. A previously recognized but unidentified long and relatively rare cDNA clone containing the entire sequence from the cap site at the 5' end to the poly(A) tail at the 3' end of the mRNA was isolated by single-step screening of the library. The size, amino acid composition, and the activity of the protein expressed in heterologous cells strongly suggest this mRNA codes for lysophospholipase.

Energy Technology Data Exchange (ETDEWEB)

The theory of ..cap alpha.. decay in first-order perturbation theory is presented. The theory is designed for a strongly deformed nucleus in an isomeric state which changes its deformation dynamically through decay from a very deformed to an almost spherical shape. It is shown that other channels are not coupled to the ..cap alpha.. channel in first-order perturbation theory. The collective degrees of freedom of the daughter nucleus are described by shape vibrational states, eigenstates of a Hamiltonian whose potential has two minima. The parent nucleus is described by dynamically coupling the vibrational degrees of freedom to the ..cap alpha..-particle motion and also taking rotations into account. The ..cap alpha.. particle is taken to be a point-like particle. The theory is applied to the ..cap alpha.. decay of the isomeric state of /sub 95//sup 242/Am.

Energy Technology Data Exchange (ETDEWEB)

A LLX procedure for carrier-free separation of the radioisotopes, {sup 47}Sc, {sup 48}V and {sup 48},{sup 49},{sup 51}Cr, the 40 MeV {alpha}-particle activation products of titanium has been developed. Sequential separations of the radionuclides produced in the titanium matrix through the nuclear reactions ({alpha}, {alpha}p{chi}n), ({alpha}, p{chi}n) and {alpha}, ({chi}n) have been performed through LLX from aqueous H{sub 2}SO{sub 4} and HClO{sub 4} acid media using the liquid cation exchanger, HDEHP, as an extractant. Purity of the carrier-free radiotracers at different stages of their separations has been verified by {gamma}-ray spectrometry. (author).

International Nuclear Information System (INIS)

Quantitative analytical electron microscopy study of dopant distribution in the microstructure of selected Nd-#alpha#-sialon samples revealed the presence of relatively large amounts of glassy phase at quadruple pockets, which exhibited a common composition similar to a melilite solution. Al segregants were depleted from adjacent grain boundaries to satisfy the 'stoichiometry' of such glass. Existence of this glass results in significant deviation of the Nd-#alpha#-sialon composition from the expected values, which shifts the #alpha#-#beta#-sialon phase boundary. Only extra Nd_2O_3 additives enable a monolithic #alpha#-sialon microstructure. The absence of similar glass in Yb-#alpha#-sialon materials keeps the phase relations from such deviations.

Energy Technology Data Exchange (ETDEWEB)

Results of an experimental study of the interaction of 140 MeV alpha particles with /sup 90/Zr nuclei resulting in fragmentation of the alpha particle are reported. The experimental observations of the study are analyzed and are found to show that alpha particle breakup reactions leading to at least 4-body final states, composed of two charged alpha particle fragments, contribute significantly to the singles yield of charged fragments observed at a fixed forward angle. The conclusions are based on coincidence measurements where one charged fragment is detected at a small forward angle which remains fixed, while the second charged fragment is detected at a series of coplanar secondary angles. The largest coincidence charged particle yield for the multiparticle final state events results from /sup 90/Zr(..cap alpha..,pp)X reactions, where both of the measured protons have energy ...

Energy Technology Data Exchange (ETDEWEB)

The high frequency, low mode number toroidicity-induced Alfven eigenmodes (TAE) are shown to be driven unstable by the circulating and/or trapped {alpha}-particles through the wave-particle resonances. Satisfying the resonance condition requires that the {alpha}-particle birth speed v{sub {alpha}} {ge} v{sub A}/2{vert bar}m-nq{vert bar}, where v{sub A} is the Alfven speed, m is the poloidal model number, and n is the toroidal mode number. To destabilize the TAE modes, the inverse Landau damping associated with the {alpha}-particle pressure gradient free energy must overcome the velocity space Landau damping due to both the {alpha}-particles and the core electrons and ions. The growth rate was studied analytically with a perturbative formula derived from the quadratic dispersion relation, and numerically with the aid of the NOVA-K code. Stability criteria in terms of the ...

UK PubMed Central (United Kingdom)

Angiokeratoma corporis diffusum with glycopeptiduria is a recently recognized inborn error of glycoprotein catabolism resulting from the deficient activity of human alpha-N-acetylgalactosaminidase (E.C....Full Text Available

UK PubMed Central (United Kingdom)

N alpha-Acetylenkephalin carboxypeptidase was co-purified with N-acetyltyrosine deacetylase from monkey kidney. Almost 90% of the activity from the homogenate was recovered in a high-speed supernatant...Full Text Available

UK PubMed Central (United Kingdom)

alpha-actinins are actin microfilament crosslinking proteins. Vertebrate actinins fall into two classes: the broadly-expressed actinins 1 and 4 (actn1 and actn4)...Full Text Available

Science.gov (United States)

Probabilistic sensitivities using the score function method are developed for a lifing analysis of an alpha + beta titanium alloy in a round bar under axial fatigue load. Sensitivities with respect to the statistical inputs of the crack initiation size (a...

UK PubMed Central (United Kingdom)

1. In normal rats and rats with bladder hypertrophy secondary to outflow obstruction, undergoing continuous cytometry, we examined the responses to the selective alpha 1-adrenoceptor antagonist doxazosin...Full Text Available

UK PubMed Central (United Kingdom)

Since a large body of data has suggested a significant role for alpha-fetoprotein (AFP) in the regulation of the immune response at a number of levels, we examined the possibility of a specific receptor...Full Text Available

International Nuclear Information System (INIS)

Synthesis genes encoding the human #alpha#- and #beta#-globin polypeptides have been expressed from a single operon in Escherichia coli. The #alpha#- and #beta#-globin polypeptides associate into soluble tetramers, incorporate heme, and accumulate to >5% of the total cellular protein. Purified recombinant hemoglobin has the correct stoichiometry of #alpha#- and #beta#-globin chains and contains a full complement of heme. Each globin chain also contains an additional methionine as an extension to the amino terminus. The recombinant hemoglobin has a C_4 reversed-phase HPLC profile essentially identical to that of human hemoglobin A_0 and comigrates with hemoglobin A_0 on SDS/PAGE. The visible spectrum and oxygen affinity are similar to that of native human hemoglobin A_0. The authors have also expressed the #alpha#- and #beta#-globin genes separately and found that the expression of the ...

UK PubMed Central (United Kingdom)

The in vitro antibacterial activities of the newly developed 7 alpha-methoxy cephalosporins and 7 beta-methoxyiminoacetamido cephalosporins against 67 clinical isolates of Bacteroides fragilis and their...Full Text Available

UK PubMed Central (United Kingdom)

Several investigations suggested abnormalities in circadian rhythms are related to the pathophysiology of psychiatric disorders, including drug addiction. Recently, orphan nuclear receptor rev-erb alpha...Full Text Available

UK PubMed Central (United Kingdom)

Alpha-hemoglobin-stabilizing protein (AHSP) is an erythroid-specific protein that acts as a molecular chaperone for the free α chains of hemoglobin. Evidence strongly suggests...Full Text Available

International Nuclear Information System (INIS)

Multi-cation #alpha#-Sialon ceramics were prepared using mixtures of samarium with calcium, magnesium, yttrium and ytterbium, and compared with a pure Sm-Sialon of equivalent total stabilising cation composition. A ratio of 80eq% samarium to 20eq% of the second stabilising additive was used. Samples were fired at 1820 deg C and subsequently heat treated at 1450 deg C. XRD phase analysis showed that all additives resulted in greater #alpha#-Sialon stability, and that calcium was the most effective additive for the stabilisation of the #alpha#-Sialon phase. Copyright (1998) Australasian Ceramic Society

KoreaScience (Korea)

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International Nuclear Information System (INIS)

English Mar 1999 [vp.] United Kingdom Jumali, MHH Warwick Univ.,

Energy Technology Data Exchange (ETDEWEB)

Alpha particle confinement is necessary for ignition of a D-T tokamak fusion plasma and for first wall protection. Due to high radiation backgrounds and temperatures, scintillators and semiconductor detectors may not be used to study alpha particles which are lost to the first wall during the D-T programs on JET and ITER. An alternative method of charged particle spectrometry capable of operation in these harsh environments, is proposed: it consists of thin foils of electrically isolated conductors with the flux of alpha particles determined by the positive current flowing from the foils. 2 refs., 3 figs.

International Nuclear Information System (INIS)

Russian (Oct 1974). USSR Grantsev, VI Dryapachenko, IP Kornilov,

Science.gov (United States)

... Accession Number : ADD100229. Title : DEFORMATION BEHAVIOR OF AN OMEGA HARDENED ALPHA-BETA TITANIUM ALLOY,. ...

International Nuclear Information System (INIS)

Nucleosynthesis and energy production in stellar environments depend critically on nuclear reaction cross sections. Reactions induced by alpha particles are important in the helium burning stage of stars, novae, and supernovae events. They involve light to medium weight nuclei up to about Z=32, and center-of-mass energies up to about 20 MeV. We are working on a project to compile and evaluate cross section data for alpha-induced reactions. These data will eventually be used to derive #alpha#-nucleus potential parameters. (author)

Science.gov (United States)

... Accession Number : ADA136144. Title : Characteristics of the Mechanical Properties and the Fractures of an Alpha Beta Titanium Alloy,. ...

International Nuclear Information System (INIS)

The possibilities, advantages, and difficulties of determining nuclear matter densities by elastic scattering of alpha-particles are generally discussed. On the basis of particular experimental data - 104 MeV alpha-particle scattering from "4"0,"4"2,"4"4,"4"8Ca - a refined folded potential is introduced using a density-dependent alpha-nucleon-interaction and target nucleus densities described by Fourier-Bessel-series. Thereby, the total nucleon densities of these isotopes were determined with little model dependence. The resulting root-mean-square radii and density differences are compared with other experimental results obtained by different methods. (orig.).

Science.gov (United States)

Pancreatic amyloid deposits of amylin are a hallmark of Type II diabetes and considerable evidence indicates that amylin oligomers are cytotoxic to beta-cells. Many efforts are presently spent to find out naturally occurring molecules, or to design synthetic ones, able to hinder amylin aggregation or to protect cells against aggregate cytotoxicity. In this context, a protective effect of some polyphenols against amyloid cytotoxicity was reported. Actually dietary polyphenols are endowed with multiple health benefits, and extra virgin olive oil is attracting increasing interest as a source of these substances. Here, we investigated the effects on amylin aggregation and cytotoxicity of the secoiridoid oleuropein aglycon, the main phenolic component of extra virgin olive oil. We found that oleuropein, when present during the aggregation of amylin, consistently prevented its cytotoxicity to RIN-5F pancreatic beta-cells, as determined by the ...

International Nuclear Information System (INIS)

The aim of this study was to compare multidetector-row computed tomography (MDCT) findings between cases of sclerosing cholangitis with autoimmune pancreatitis (SC-AIP) and infiltrative extrahepatic cholangiocarcinoma (IEC). We retrospectively assessed MDCT findings from 16 IEC cases and 13 SC-AIP cases. MDCT findings were analyzed with regard to location, length, wall thickness, contour, stricture wall enhancement pattern, proximal duct diameter, and the presence of diffuse concentric thickening in the proximal duct and gallbladder wall thickness. Stricture length, stricture wall thickness, and proximal duct diameter were significantly smaller for SC-AIP than for IEC: 19.3#+-#8.7 vs. 31.8#+-#12.0 mm (P=0.004), 2.1#+-#1.3 vs. 4.1#+-#1.3 mm (P<0.001), and 9.2#+-#3.9 vs. 13.3#+-#5.0 mm (P=0.012), respectively. SC-AIP was correlated with stricture location in both the intrapancreatic and hilar hepatic bile ducts, concentric stricture contour (P<0.001), and ...

International Nuclear Information System (INIS)

The influence of structure on mechanical properties in the course of tensile tests in a wide range of temperatures was studied, using the VT16 structure thermally strengthened (alpha+beta)-titanium alloy by way of example. It is ascertained that transition from ductile to brittle fracture at the temperature of -196 deg C is observed only in coarse-grain alloy having alpha-eldging of beta grains.

International Nuclear Information System (INIS)

Immobilization of long-lived fission products (LLFP) such as radioactive Tc, Cs and Sr into #alpha#-SiAlON ceramics was evaluated using stable isotopes instead of radioactive isotopes, and the applicability of #alpha#-SiAlON ceramics as the inert matrix for transmutation of LLFP was investigated. In the case of single addition of SrO, SrCO_3, Cs_2CO_3 or ReO_2 to the starting materials, #alpha#-SiAlON, single phase was not formed after hot-pressing. When Y_2O_3 was added with SrO, SrCO_3 or Cs_2CO_3 to the starting materials (#alpha#-Si_3N_4, AlN and #alpha#-Al_2O_3) in optimum compositions, #alpha#-SiAlON single phase was obtained after hot-pressing at 1700degC or 1800degC. From the EDS analysis, Sr and Y were detected from grains. It is suggested that Y would assist the expansion of interstices of #alpha#-SiAlON lattice, resulting in the ...

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We develop the formalism of a unified semi-microscopic description of low-energy proton and {alpha}-particle interaction with nuclei. We analyze elastic and inelastic proton scattering at the energy 25.05 MeV and {alpha}-particle scattering at the energy 104 MeV by the {sup 90}Zr nucleus. Information is obtained on differences in the deformation of the proton and neutron distributions. We study the energy dependence of the semi-microscopic {alpha}-particle potential including the energy dependence of the potential geometry.'' We analyze the change in angular distributions of elastically scattered {alpha} particles with increase of energy and the contribution to the scattering cross section from nucleon-nucleon correlations.

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Proton and alpha decay from the giant resonance region of {sup 28}Si excited with a 129 MeV alpha particle beam has been measured in coincidence with inelastic alpha particles detected at 0{degree}. The angular correlation data show the presence of decay from both {ital E}0 and {ital E}2 giant resonances. The {ital E}0 giant resonance decays primarily through the {alpha}{sub 0}, {alpha}{sub 1}, {ital p}{sub 0}, and {ital p}{sub 1,2} channels with the branching ratios 18{plus minus}6 %, 24{plus minus}8 %, 23{plus minus}9 %, and 18{plus minus}8 %, respectively. Substantial direct decay is observed.

International Nuclear Information System (INIS)

Differential cross sections of the (#alpha#, t) reactions on "4"5Sc, "5"1V, and "5"9Co nuclei are measured in the 10-71 deg, 10-155 deg, and 10-171 deg angular ranges, respectively, with 27.2 MeV alpha particles. The cross sections have also been calculated on the basis of the distorted wave theory. The possibility of an unambiguous choice of the optical potential for alpha particles is discussed. The angular distribution calculations using several combinations of the optical potentials in the inlet and outlet channels of the reactions show that consistence between the calculations and the measurements is achieved (especially in angular range, less than 90 deg, if one of the potentials is chosen to be a sufficiently deep one.

International Nuclear Information System (INIS)

"2"7Al and "2"9Si solid-state NMR spectra and X-ray diffraction (XRD) patterns were obtained for #alpha#-SiAlON powders prepared by combustion synthesis, according to which the phase transformation and structure evolution of #alpha#-SiAlON were studied. It was found that in #alpha#-SiAlON "2"9Si chemical shift values (-48 < #delta# _S_i < -47) were close to those in #beta#-Si_3N_4 and #alpha#-Si_3N_4, indicating that Si atoms kept SiN_4 coordination to a large extent in #alpha#-SiAlON despite the presence of O atoms. Dissimilarly, "2"7Al chemical shift values in #alpha#-SiAlON deviated clearly from that corresponding to AlN_4 coordination (#delta# _A_l #approx# 112) and occurred in a range from #delta# _A_l 95.5 to 99.9, which should be assigned to tetrahedral AlO _xN_4_-_x (0 #<=# x #<=# 4) coordination. The broadening effect of AlO _xN_4_-_x peaks ...

Science.gov (United States)

Abstract: Snake venom contains a number of small proteins,enzymes and other components,which displays a broad spectrum of biological activities. With the ability of specifically binding on acetylcholine acceptor, alpha-bungarotoxins are not only useful molecular probes in investigating the mechanism of neural signal transmission, but also potential pharmic preparations for neural disease treatment. In current research,cDNAs of Bungarus multicinutus venom gland were synthesized using SMART cDNA amplification kit and then, alpha-bungarotoxin genes were cloned and sequenced. Total of 20 clones were sequenced representing 14 isotoxin mRNAs of alpha-bungarotoxins. Among those clones, a novel isotoxin gene was subcloned into two expression plasmids, alpha-BgTX/pQE30a and alpha-BgTX/pGEX-4T-1, and transformed into E. coli. After inducing with IPTG, fused protein of ...

International Nuclear Information System (INIS)

The possibility of having Sr as an interstitial metal cation in #alpha#-SiAlON has been investigated in two systems: a single-cation system (Si_3N_4-SrO-AlN) and a multication system (Si_3N_4-(Y_2O_3/SrO/CaO)-AlN). It was found that Sr alone does not form #alpha#-SiAlON and that Sr could only be accommodated in #alpha#-SiAlON in conjunction with Y and Ca. The Sr content of #alpha#-SiAlON increased as the total content of (Y + Ca) increased and appeared to reach a limit at 0.5 at.%, or 0.15 atom per #alpha#-SiAlON. Unexpectedly, some of the #alpha#-SiAlON that contained (Sr + Y + Ca) was present as laths or fibers with the c-axis perpendicular to the hot-press direction.

International Nuclear Information System (INIS)

Rare earth stabilised #alpha#-SiAlONs are commonly observed with an equiaxed grain morphology. Elongated #alpha#-SiAlON has been observed in some of these systems, however it usually results from special techniques such as pressure sintering. The formation of elongated #alpha#-SiAlON grains during pressureless sintering has been shown to commonly occur in the Ca #alpha#-SiAlON system. Examination of phase and microstructural development in three Ca #alpha#-SiAlON compositions in the temperature range 1400 deg to 1800 deg C showed that phase development and grain growth occurred at different temperatures. It was found that chemical reactions were completed by 1550 deg C, however significant grain growth did not occur at this temperature. Grain growth progressed from 1600 deg C and continued up to 1800 deg C, the maximum temperature investigated. At 1800 deg C, ...

CERN Document Server

We construct a sample of low-redshift Ly-alpha emission-line selected sources from GALEX grism spectroscopy of nine deep fields to study the role of Ly-alpha emission in galaxy populations with cosmic time. Our final sample consists of 122 (142) sources selected in the redshift interval z=0.195-0.44 (z=0.65-1.25) from the FUV (NUV) channel. We classify the Ly-alpha sources as AGNs if high-ionization emission lines are present in their UV spectra and as galaxies otherwise. These classifications are broadly supported by comparisons with X-ray and optical spectroscopic observations. We classify additional sources as AGNs using line widths for our Ly-alpha emitter (LAE) analysis. Defining the GALEX LAE sample in the same way as high-redshift LAE samples, we show that LAEs constitute only about 5% of NUV-continuum selected galaxies at z~0.3. We also show that they are less common at z~0.3 than they are at ...

Energy Technology Data Exchange (ETDEWEB)

A technique has been developed for high resolution alpha particle spectroscopy from track length determination in CR-39 plastic. On individual tracks an energy resolution deltaE close to the range straggling limit is obtainable. For 6 MeV alpha-particle deltaE is proportional 35 keV on individual particles and for groups of particles deltaE proportional 20 keV can be achieved using certain data selection criteria. At 100 keV on individual particles deltaE is proportional 20 keV. The analysis requires 1) a knowledge of the track-etch rate (Vsub(T))-range relationship and 2) a theoretical understanding of alpha-particle track structure in CR-39 as a function of particle energy, dip angle and degree of etching. The structure of alpha-particle etched tracks in CR-39 is described and two methods of analysis discussed. Examples are given of the resolution attainable on tracks of ...

International Nuclear Information System (INIS)

The crystallography of #alpha#(hcp) precipitates formed on the #beta#(bcc) matrix grain boundaries has been studied with transmission electron microscopy (TEM) in a Ti-15V-3Cr-3Sn-3Al alloy. The #alpha# precipitates have a near-Burgers orientation relationship with respect to at least one of the adjacent #beta# grains. Among the possible 12 variants in this orientation relationship, the variant that [11 bar 20]_#alpha# is parallel to the _#beta# closest to the grain boundary plane tends to be preferred by the #alpha# precipitates. Additionally, further variant selections are made so as to minimize the deviation of orientation relationship with respect to the ''opposite'' #beta# grain from the Burgers one. Such rules in variant selection often result in the formation of precipitates with a single variant at a planar grain boundary. Prior small deformation of #beta# matrix changes the variant of ...

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The neuronal nicotinic acetylcholine receptor {alpha}7 subunit is a member of a family of ligand-gated ion channels, and is the only subunit know to bind {alpha}-bungarotoxin in mammalian brain. {alpha}-Bungarotoxin binding sites are known to be more abundant in the hippocampus of mouse strains that are particularly sensitive to nicotine-induced seizures. The {alpha}7 receptor is highly permeable to calcium, which could suggest a role in synaptic plasticity in the nervous system. Auditory gating deficiency, an abnormal response to a second auditory stimulus, is characteristic of schizophrenia. Mouse strains that exhibit a similar gating deficit have reduced hippocampal expression of the {alpha}7 subunit. We have cloned and sequenced the full length cDNA for the mouse {alpha}7 gene (Acra-7) and characterized its gene structure. The murine ...

International Nuclear Information System (INIS)

Precise measurements of alpha particle counting efficiencies have been made using isotropic, infinitely thin alpha emitting sources placed in direct contact with a thin, end-window, gas flow proportional detector. Except for alpha particle absorption in the window material, this geometry approaches 2#pi#, such that the only other variation in the response of the counter is from the random decay of the source. The data are fitted to the expected linear function of count rate versus window thickness and the resulting fitting parameters are used to calculate the counting efficiencies for a given thickness of window material. Counting efficiencies for 5.31, 6.06, and 8,78 MeV alpha particles have been determined from sources of "2"1"0Po and the progeny of "2"1"2Pb. For the particular counter used, the counting efficiencies in counts per alpha and their respective relative standard ...

International Nuclear Information System (INIS)

Radiation therapy has had a significant and an expanded role in the management of cancer of the pancreas during the last decade. In particular, for locally advanced disease, radiation therapy has improved the median survival of patients to 1 year. Intraoperative electron beam therapy has been applied to unresectable and resectable pancreatic cancer in an attempt to enhance local control of disease and to improve patient survival. This paper presents a survey of the role of radiation therapy in treatment of cancer of the pancreas, provides information on the radiobiological aspects of this treatment modality and details the physical and dosimetric characteristics of intraoperative radiation therapy with electrons. Presented are the design specifics of an applicator system, central axis beam data, applicator parameters, dose distribution data, shielding, treatment planning and means of verification. Emphasis is placed on the collaboration and cooperation necessary ...

International Nuclear Information System (INIS)

A radioimmunoassay is described for the molluscan neuropeptide, Phe-Met-Arg-Phe-NH"2(FMRFamide). The antibody used is C-terminal-specific and shows slight but significant (1-2%) cross-reactivity with chicken pancreatic polypeptide (APP). The assay has been used to identify in rat brain extracts a pair of molecules that may represent mammalian counterparts of FMRFamide. Their concentrations were highest in spinal cord and hypothalamus (>10 pmol.g"-_1) and lowest in cerebellum and striatum (<3.5 pmol.g"-_1). The two immunoreactive peptides were separated on CM ion-exchange chromatography where they appeared to be less basic than FMRFamide. On Sephadex G50 gel filtration one eluted in a similar position to FMRFamide and the other slightly earlier suggesting it may be of higher molecular weight. The rat immunoreactive components do not correspond to previously described neuropeptides or hormones, and may be members of a new group of mammalian neuropeptides with ...

Energy Technology Data Exchange (ETDEWEB)

Serum ferritin levels were measured in 72 normal subjects and in 214 cases with various diseases by an immunoradiometric assay. In normal subjects, the serum ferritin levels were 27-230 ng/ml. Elevated serum ferritins were observed in most cases with iron excess and acute hepatitis. Markedly elevated levels were found in the majority of cases with acute leukemia, malignant lymphoma, hepatoma, and pancreatic cancer. High ferritin levels were also found in other malignant diseases. However, the range overlapped broadly with that of nonmalignant diseases. The serum ferritin correlated significantly with serum iron in normals and in those with iron deficiency anemia. In most nonmalignant cases, the serum ferritin and iron levels distributed on a regression line obtained from levels in normals and those with iron deficiency anemia. However, 92% of the malignant cases showed a serum ferritin to iron ratio higher than that of normal subjects. The estimation of the serum ...

International Nuclear Information System (INIS)

For several decades, ceramic matrix composite have been attracted attention in advanced structural and tribological applications. Advanced structural ceramics are presently used in diverse tribological applications such as tips for ballpoint pens, precision instrument bearings and cutting tools inserts. Design and selection of ceramics for these applications require reliable data on the effects of temperature, load and environment on the tribological behavior of these ceramics. In the present work, #alpha#-sialon matrix composites reinforced with different amounts of #beta#-sialon fibers were produced with the aim of improving their toughness to increase the industrial applications. The wear properties of #alpha#-sialon matrix composites were evaluated by carried out wear tests using a pin-on-disk tribometer under dry conditions. The #alpha#-sialon matrix composites were manufactured by slip casting and sintered by uniaxial ...

CERN Document Server

The effect of one on-ramp (entry) and one off-ramp (exit) is investigated numerically in one dimensional-cellular automaton traffic flow model, with open boundary conditions, using parallel dynamics. Our aim in this paper is to study how the injecting rates $\\alpha$ and $\\alpha_{0}$ and the extracting rates $\\beta$ and $\\beta_{0}$ acts on the density and flux of cars in one dimensional road. The priority of occupation at entry site $i_{1}$ (moving at exit site $i_{2}$) is attributed to the particle which entered (absorbed) in the chain. Phase diagrams in ($\\beta_{0},\\alpha_{0}$), and ($\\beta,\\alpha_{0}$) plans are established. For $\\alpha=0.1$, they show three different topologies in the flow behaviour. The first one correspond to the presence of four regions, by varying $\\alpha_{0}$; namely low density phase (LDP), intermediate density phase (IDP), ...

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A radiochemical charged particle activation procedure for production and separation of carrier free {sup 52,56}Mn, {sup 55,56,58}Co and {sup 56,57}Ni has been developed. The radioisotopes produced on bombardment of an iron foil target with a 40 MeV {alpha}-particle beam through the nuclear reactions, Fe({alpha}, {alpha}pxn){sup 52,56}Mn, Fe({alpha}, pxn){sup 55,56,58}Co and Fe({alpha}, nx){sup 56,57}Ni, have been separated by LLX. The target element and the activation products have been sequentially separated from an HCl medium using diethylether and the liquid anion exchanger, TIOA, as extractants. Extent of separation and purity of the carrier free radiotracers at different stages of their LLX separation have been verified by taking recourse to {gamma}-ray spectrometry. (Author).

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Powders with nominal compositions (in atomic percent) Ti-48Al and Ti-48Al-2Nb-2Cr were prepared by the plasma rotating electrode process (PREP) and gas atomization (GA) techniques. As-solidified and heat-treated (1000degC per 3 h) powder samples were examined by metallography, scanning electron microscopy, X-ray diffraction and transmission electron microscopy. The microstructures of the powders were characterized as a function of atomization technique, alloy content, powder particle size (solidification rate) and thermal history. All of the as-solidified powders were comprised of disordered [alpha], and ordered [alpha][sub 2]-Ti[sub 3]Al and [gamma]-TiAl. For both alloys, a larger volume fraction of [alpha] and [alpha][sub 2] was observed in the PREP powders relative to GA powders of comparable size. Additionally, for both alloys and both atomization techniques, the volume fraction of ...

Energy Technology Data Exchange (ETDEWEB)

The unit cost of energy production of wind generators is examined by means of a model of the turbine power curve and the Weibull model of wind probability function, by applying the usual economic equations. The analysis is carried out in terms of dimensionless variables whose range of variability is defined by examining the data of 80 modern commercial wind turbines; likewise, the economic parameters are based on the present state of costs. The unit cost decreases asymptotically when alpha (ratio between mean wind speed and cut-in speed) - increases and shows a lower limit of 2 to 5 Ecent/kWh. This cost depends both on the value of the machine parameter {phi} (ratio between nominal and cut-in speed) and on the basic prices. The effect of the Weibull shape parameter kappa is different according to the values of {alpha} and {phi}: with low {alpha} and high {phi} the unit cost increases along with {kappa} (that is with the ...

CERN Document Server

We compute the complete two-loop O(alpha) Wilson coefficients relevant for radiative decays of the B meson in the SM. This is a necessary step in the calculation of the O(alpha alpha_s^n ln^n m_b/M_W) corrections and improves on our previous analysis of electroweak effects in B -> X_s gamma. We describe in detail several interesting technical aspects of the calculation and include all dominant QED matrix elements. In our final result, we neglect only terms originated from the unknown O(alpha alpha_s) evolution of the Wilson coefficients and some suppressed two-loop matrix elements. Due to the compensation among different effects, we find that non-trivial electroweak corrections decrease the branching ratio by about 3.8% for a light Higgs boson, in agreement with our previous analysis. As in [1], the corresponding SM prediction for the branching ratio with E_gamma > 1.6 GeV is ...

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The effect of the nitrogen uptake in {alpha}-iron upon spark erosion in gaseous and liquid ammonia, plasma nitriding, and plasma immersion ion implantation is studied. The resulting phases and hyperfine parameters, measured by the Moessbauer spectroscopy, are discussed from the point of view of initial conditions of their preparation and subsequent heat and/or mechanical treatment. Spark erosion in the ammonia gas produces fine particles with the dominating ferromagnetic {alpha}-Fe phase (50%). The 20% of specimen volume form {alpha}'-Fe and {alpha}''-Fe{sub 16}N{sub 2} phases. The last 30% occupy the {gamma}'-Fe{sub 4}N, ferro- and paramagnetic {epsilon} phases, and {gamma}-Fe(N). Nitriding in the liquid ammonia allows to incorporate the higher content of nitrogen into {alpha}-iron particles which results in the formation of paramagnetic ...

Energy Technology Data Exchange (ETDEWEB)

New and elaborate techniques for alpha-particle autoradiography of thick specimens based on the plastic nuclear track detector CR-39 have been developed. These permit a full analysis of both trace element and microdistribution of alpha-active nuclides present. The important features of the techniques are: 1) reliable low level configuration down to 10/sup -15/ Ci g/sup -1/, 2) high resolution alpha-particle spectroscopy in CR-39, 3) determination of the absolute abundance of alpha active nuclides present in the specimen, 4) determination of the distribution of emission with height up to 30 microns above the surface of the autoradiograph, 5) the local determination of the radon diffusion coefficient in the specimen which is needed to calculate the activity levels of /sup 222/Rn and daughter nuclei, 6) the analysis of small and large clusters of alpha-particle activity recorded on the ...

CERN Document Server

The Drell-Yan mechanism for the production of lepton pairs is one of the most basic processes for physics studies at hadron colliders. It is therefore important to have accurate theoretical predictions. In this work we compute the two-loop virtual mixed QCD x QED corrections to Drell-Yan production. We evaluate the Feynman diagrams by decomposing the amplitudes into a set of known master integrals and their coefficients, which allows us to derive an analytical result. We also perform a detailed study of the ultraviolet and infrared structure of the two-loop amplitude and the corresponding poles in epsilon.

International Nuclear Information System (INIS)

The K_#beta#/K_#alpha# X-ray intensity ratios are measured for Mn and Fe and for six other elements with Z lying in the range 49<=Z<=82 following electron capture decay and photon excitation using "2"4"1Am and "5"7Co sources. High-resolution Si(Li) and HpGe detector systems were used in the experiments. The dependence of K_#beta#/K_#alpha# values on the mode of excitation in the case of Mn and Fe is attribuited to the chemical effects, while no such dependence is found for the high-Z elements.

International Nuclear Information System (INIS)

Hitherto in this laboratory, ionization coefficients alpha and attachment coefficients #eta# have been determined from Townsend's discharge experiments by a curve-fitting method. However, the method proved to be laborious, Formulae have been derived in this paper to give value of alpha and #eta# as a function of Isubo, Isub1 and Isub2 where Isubo is the photoelectric current at a gap setting d and Isub2 the current at another gap setting 2 d. The values of alpha and #eta# obtained give currents in agreement to within 3% in the best cases with the observed currents.

International Nuclear Information System (INIS)

The effect of variations of the fundamental constants on the thermonuclear rate of the triple alpha reaction, "4He(#alpha##alpha#, #gamma#)"1"2C, that bridges the gap between "4He and "1"2C is investigated. We have followed the evolution of 15 and 60 M#centre dot# zero metallicity stellar models, up to the end of core helium burning. They are assumed to be representative of the first (Population III) stars. The calculated oxygen carbon abundances resulting from helium burning can then be used to constrain the variation of the fundamental constants.

International Nuclear Information System (INIS)

Nano-indentation has been used to assess the hardness of equiaxed grains of #alpha#-Ti as a function of orientation. Surface normals of these grains in metallographic sections were assessed using orientation imaging microscopy. Thin membranes of material from below a series of nano-indentations were excised by use of a dual-beam focused ion beam instrument. In this way, the dislocation substructures beneath individual indentations were characterized using transmission electron microscopy, permitting an identification of both statistically stored and geometrically necessary dislocations.

Energy Technology Data Exchange (ETDEWEB)

Bremsstrahlung emitted in the {alpha}+p reaction at 50 MeV/nucleon was studied using a 200 MeV {alpha}-particle beam and a liquid hydrogen target. Double-differential photon cross sections were measured over a wide range of angles and energies. Coherent bremsstrahlung was found to be strong for all photon energies. The cross section is enhanced at the highest photon energies and is characteristic of direct capture to the unbound {sup 5}Li ground and first excited state. With direct capture as a limiting case of coherent bremsstrahlung a consistent reaction picture can be obtained.

Energy Technology Data Exchange (ETDEWEB)

This paper describes and analyzes a dithering technique for accurately specifying small values of opacity ({alpha}) that would normally not be possible because of the limited number of bits available in the alpha channel of graphics hardware. This dithering technique addresses problems related to compositing numerous low-opacity semitransparent polygons to create volumetric effects with graphics hardware. The paper also describes the causes and a possible solution to artifacts that arise from parallel or distributed volume rendering using bricking on multiple GPU's.

Science.gov (United States)

Models are proposed which explain the mechanism of action on a molecular level for the initiation of cancer by electrons or alpha particles. (ACR)

International Nuclear Information System (INIS)

(7 Jan 1974). Netherlands Rebel, H. Hauser, G. Schweimer, GW Nowicki,

Science.gov (United States)

Hilled Bend Spechene of an Alpha-Beta Titanium Alloy. Ti-6M14V. ..... The all beta titanium alloy was nllled from both sides; only the edges were taped. ...

International Nuclear Information System (INIS)

Russian 1984. p. 353. USSR Smirnov, AV Antropov, AE Zarubin, PP

International Nuclear Information System (INIS)

The purpose of this experimental study is to investigate the micromechanical fatigue behavior, in terms of slip nature and preferential cracking sites, of a commercial #alpha#/#beta#-forged Ti-6Al-4V alloy. Electron backscattering diffraction is extensively used to identify the deformation (prismatic, basal, pyramidal slip) and crack formation modes activated by fatigue at the surface of several hundred primary #alpha# nodules. Some fatal crack formation sites are also characterized. Cracking in basal planes is identified as the most critical damage mode leading to fracture. An explanation is proposed which involves the resolved shear stress, taking into account the Schmid factor and the normal stress in relation to the elastic anisotropy of the #alpha#-phase. Finally, the spatial distribution of the secondary cracks is analyzed according to the crystallographic textures (macrozones) present on a mesoscopic scale in the ...

CERN Document Server

We discuss the foundations of factor or regression models in the light of the self-consistency condition that the market portfolio (and more generally the risk factors) is (are) constituted of the assets whose returns it is (they are) supposed to explain. As already reported in several articles, self-consistency implies correlations between the return disturbances. As a consequence, the alpha's and beta's of the factor model are unobservable. Self-consistency leads to renormalized beta's with zero effective alpha's, which are observable with standard OLS regressions. Analytical derivations and numerical simulations show that, for arbitrary choices of the proxy which are different from the true market portfolio, a modified linear regression holds with a non-zero value $\\alpha_i$ at the origin between an asset $i$'s return and the proxy's return. Self-consistency also introduces ``orthogonality'' and ``normality'' conditions ...

International Nuclear Information System (INIS)

(Dec 1973). United States Chevarier, A. Chevarier, N. Demeyer, A.

International Nuclear Information System (INIS)

English 2005 p. 240 Russian Federation Fadeev, SN Gridnev, KA Institute

International Nuclear Information System (INIS)

1976. Germany Ramaswamy, MK Birla Inst. of Tech. and Science, Pilani

Energy Technology Data Exchange (ETDEWEB)

New phosphates with NaZr{sub 2}(PO{sub 4}){sub 3} structure of the B{sub 0.5}FeTa(PO{sub 4}){sub 3}-type (where B-Ca, Sr, Ba) are synthesized and characterized by X-ray diffraction analysis and IR-spectroscopy. The heating behavior of the phosphates is studied using high-temperature X-ray crystallography in the range 15-625 deg. C. The unit-cell parameters, the coefficients of thermal expansion {alpha}{sub a}, {alpha}{sub c} and their thermal expansion anisotropy |{alpha}{sub c} - {alpha}{sub a}| of the phosphates under study are determined and the dependences of these characteristics on the nature of cations are established and analyzed.

UK PubMed Central (United Kingdom)

While the etiology of Parkinson's disease remains largely elusive, there is accumulating evidence suggesting that mitochondrial dysfunction occurs prior to the onset of symptoms in Parkinson's disease....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Crystalline {alpha}-Fe{sub 2}O{sub 3} powder was prepared by the mechanical milling of crystalline {alpha}-FeOOH at room temperature in air. This result means that crystalline {alpha}-FeOOH is dehydrated by mechanical milling at room temperature. The obtained {alpha}-Fe{sub 2}O{sub 3} powder worked as a rechargeable electrode material in lithium ion conductive organic electrolytes. The electrodes exhibited high discharge capacities of over 1000mAhg{sup -1} corresponding to 6 Li per {alpha}-Fe{sub 2}O{sub 3} at potentials ranging from the open circuit potential to 0.5V (versus Li{sup +}/Li) in the first discharging (lithium insertion) process. This suggests that the valence deviation from Fe{sup 3+} in {alpha}-Fe{sub 2}O{sub 3} to Fe{sup 0} may be caused by electrochemical reduction. In contrast, after the first discharge, the electrodes exhibited high charge ...

International Nuclear Information System (INIS)

Russian 1986. p. 329. USSR Smirnov, AV Antropov, AE Zarubin, PP

International Nuclear Information System (INIS)

(1974). Romania Gils, HJ Rebel, H. Kernforschungszentrum Karlsruhe

International Nuclear Information System (INIS)

(Feb 1972). United States Nelson, HG Williams, DP Stein, JE v. 3(2)

International Nuclear Information System (INIS)

Russian 1974. USSR Alekseev, VV Nemets, OF Stryuk, Yu.S. Tokarevskij,

International Nuclear Information System (INIS)

Effect of globular structure parameters - size of primary #alpha#-phase particles (bsub(I)), thickness and amount of plates of secondary #alpha#-phase (bsub(II), #gamma#sub(II#alpha# )) - on a complex of mechanical properties (#sigma#sub(#beta#), S, phi, asub(H), asub(T), Ksub(Q), #sigma#sub(-1), #sigma#_1_0_0"4"5"0, #sigma#sub(0.2/100)) of VT3-1 (#alpha#+#beta#)-titanium alloy is studied. The dependences obtained allow one to determine globular structure parameters, providing necessary mechanical properties. In combination with data on the effect of thermal treatment conditions on structure parameters, results obtained in the paper may be used for structure control to increase a level of required characteristics.

International Nuclear Information System (INIS)

(1 Apr 1975). United Kingdom Gils, HJ Rebel, H. Nowicki, G. Ciocanel, A.

International Nuclear Information System (INIS)

Portuguese 2004 p. 187 Brazil Santos, C. Strecker, K. Suzuki, PA

Science.gov (United States)

Highly intelligent, confident, and successful, alpha males represent about 70% of all senior executives. Natural leaders, they willingly take on levels of responsibility most rational people would find overwhelming. But many of their quintessential strengths can also make alphas difficult to work with. Their self-confidence can appear domineering. Their high expectations can make them excessively critical. Their unemotional style can keep them from inspiring their teams. That's why alphas need coaching to broaden their interpersonal tool kits while preserving their strengths. Drawing from their experience coaching more than 1,000 senior executives, the authors outline an approach tailored specifically for the alpha. Coaches get the alpha's attention by inundating him with data from 360-degree feedback presented in ways he will find compelling--both hard-boiled metrics and vivid ...

International Nuclear Information System (INIS)

(21 Jan 1974). Netherlands Lega, J. Macq, PC Louvain Univ. (Belgium)

International Nuclear Information System (INIS)

Short note. 1 ref.; 1 tab.

UK PubMed Central (United Kingdom)

BackgroundFunction exertion of specific proteins are key factors in disease progression, thus the systematical identification of those specific proteins is a prerequisite to understand...Full Text Available

International Nuclear Information System (INIS)

Russian 1979. p. 328. USSR Burtebaev, NT Dujsebaev, AD Ivanov, GN

International Nuclear Information System (INIS)

(#alpha#+#beta#)-SiALON ceramic composites are industrially important materials. Due to their unique chemistry, crystal structure and microstructural features, #alpha#-SiAlON has superior hardness while #beta#-SiALON offers high strength and toughness. The combination of the two phases enables materials engineers to design a ceramic where the physical properties of the composite can be tailored to a particular application. This article presents a general review of the crystal structures, fabrication and properties of the (#alpha#+#beta#)-SiALON composites with special highlights outlining how microstructural tailoring can control the properties of these advanced ceramic alloys. Copyright (1997) Institute of Metals and Materials Australasia Ltd.

International Nuclear Information System (INIS)

L_#alpha#/L_l X-ray intensity ratios have been measured in elements Ta, W, Au, Hg, Tl, Pb, Bi, Th and U using L-shell photoionization by 60 keV photons. The present results are found to agree with the calculated values of Scofield within experimental uncertainties. (author).

International Nuclear Information System (INIS)

The elastic scattering angular distributions of 25 MeV alpha particles scattered from "7"3Ge, "8"9Y, "9"0Zr, "9"1Zr"9"4Zr, "9"3Nb, "4"4Ca and "4"5Sc have been measured experimentally, and fitted using a conventional optical model. (author).

International Nuclear Information System (INIS)

Tensor polarization of "6Li(2.18 MeV, 3"+) nucleus at inelastic scattering of #alpha# particles for #THETA#_l_a_b=45 deg angle is measured. The results are described by the calculations in terms of Born approximation of distorted waves with internucleonic interaction realistic potential.

International Nuclear Information System (INIS)

... lutetium isotopes nuclei odd-even nuclei radioisotopes rhenium isotopes

International Nuclear Information System (INIS)

The energy distribution of neutrons generated due to bombardment of 40 MeV alpha particles on thick elemental tantalum is measured using threshold activation detectors. A method of unfolding the neutron spectrum from the activation data based on information-entropy weighted average solution is described. The present unfolding method does not require 'a priori' information about the shape of the solution spectrum. 16 refs. (author).

International Nuclear Information System (INIS)

The physical methods were used to study the decomposition of a metastable #beta#-solid solution in the VT22 two-phase titanium alloy. It is shown that the martensitic #beta# #-># #alpha#'' transformation in doped-element depleted microvolumes of the #beta#-solid solution are dominanted and the long-time multistage decomposition through a number of intermediate states in others.

UK PubMed Central (United Kingdom)

Although peroxisome proliferator-activated receptor alpha (PPARα) is closely associated with myocardial fatty acid metabolism, the pathophysiological role of PPARα in myocardial infarction...Full Text Available

International Nuclear Information System (INIS)

The emission of #alpha# particles in coincidence with the most deeply inelastic heavy-ion reactions has been studied for "1"8"1Ta + "1"6"5Ho at 1354 MeV laboratory energy and /sup nat/Ag + "8"4Kr at 664 MeV. #alpha# particle energy spectra and angular distributions, in coincidence with a projectile-like fragment, were acquired both in the reaction plane and out of the reaction plane at a fixed in-plane angle. The in-plane data for both systems are employed to show that the bulk of the #alpha# particles in coincidence with the deep-inelastic exit channel can be explained by evaporation from the fully accelerated fragments. Average velocity diagrams, #alpha#-particle energy spectra as a function of angle in several rest frames, and #alpha#-particle angular distributions are presented. The out-of-plane #alpha# particle angular distributions and the #gamma#-ray ...

International Nuclear Information System (INIS)

Our studies on K#beta#/K#alpha# X-ray intensity ratios of some of the technologically important 3d-transition metal compounds have been reviewed. Comparison of the experimental results with single-configuration Dirac-Fock calculations provided important information on the valence states of the transition metals in various compounds, which can be helpful in understanding the nature of bonding in the compounds. (author)

International Nuclear Information System (INIS)

Ksub(#beta#)/Ksub(#alpha#) X-ray intensity ratios have been measured for various elements between Z = 29 and Z = 79 for incident proton energies of 23.6, 32.1 and 43.6 MeV. The results yield no evidence for a variation in ratio with particle energy. (orig.).

International Nuclear Information System (INIS)

The study by impedance and photoelectrochemical measurements of passive films formed on an AISI 304 type stainless steel shows that important parameters of the electronic structure of these films are modified under #alpha# irradiation, namely: width of the space charge region, donors concentration and diffusion length for minority carriers. The consequences of #alpha# irradiation on localized corrosion processes are discussed.

International Nuclear Information System (INIS)

Cyclic strength of #alpha#+#beta#-titanium alloy BT3-1 is studied under load frequencies of 33 and 300 Hz. The increase in the cyclic strength with growing frequency is caused by formation of FCC interphase layers of titanium hydrides. Their formation is one of possible ways of raising the fatigue strength of titanium alloys. Peculiarities of FCC interlayer formation in #alpha#+#beta# phases under loading frequency variation are revealed.

International Nuclear Information System (INIS)

The Ksub(#beta#)/Ksub(#alpha# 12) x-ray intensity ratio of the Si K spectrum was measured for proton impact on Si0_2 in the energy range 300-800 keV. An energy dependence of the intensity ratio was found and an explanation is given in terms of multiple ionisation. (author).

International Nuclear Information System (INIS)

The electronic structure of octahedral metal atom clusters Me_6 of 3d, 4d, and 5d transition metal atoms (V, Cr; Nb, Mo; Ta, W) has been calculated applying two different quantum-chemical approximation methods (Extended Hueckel (EH) method; SW-Xsub(alpha) method). Equilibrium structures, energy level schemes, Fermi energies and band widths as well as densities of states of clusters are discussed in detail.

International Nuclear Information System (INIS)

Results on defect structure study and degree of molybdenum radiation hardening irradiated by fission neutrons and medium energy alpha-particles are presented. It is shown that molybdenum irradiation by alpha-particles and neutrons leads to different degree of material hardening for the same damage level. It is established that molybdenum radiation hardening is mainly defined by radiation defect clusters visible in electron microscope whose coefficient of rigidity depends on their size. 5 refs.; 6 figs.; 2 tabs. (author).

International Nuclear Information System (INIS)

Chemical influences on the relative Ksub(#nu#)/Ksub(#alpha#) x-ray intensity ratio up to five per cent were found for different chemical constitutions of Cr, Mn, Fe and Cu by very precise PIXE measurements. In the discussion of these effects, screening of 3p electrons by a varying 3d valence charge, as well as polarisational effects are of importance. (author).

UK PubMed Central (United Kingdom)

Several closely related Mn(II)-oxidizing alpha-Proteobacteria were isolated from very different marine environments: strain SI85-9A1 from the oxic/anoxic interface of a stratified...Full Text Available

International Nuclear Information System (INIS)

Defects are produced in zinc by 6.1 MeV #alpha#-particle irradiation at 4.2 K and the subsequent recovery between 4.2 and 22 K. No evidence is found for free migration of an interstitial in the temperature range investigated. The recovery spectra reveal a series of substages which are ascribed to recombination of close Frenkel pairs. (author).

CERN Document Server

First results are presented from an analysis of data from the DRIFT-IIa and DRIFT-IIb directional dark matter detectors at Boulby Mine in which alpha particle tracks were reconstructed and used to characterise detector performance--an important step towards optimising directional technology. The drift velocity in DRIFT-IIa was [59.3 +/- 0.2 (stat) +/- 7.5 (sys)] m/s based on an analysis of naturally-occurring alpha-emitting background. The drift velocity in DRIFT-IIb was [57 +/- 1 (stat) +/- 3 (sys)] m/s determined by the analysis of alpha particle tracks from a Po-210 source. 3D range reconstruction and energy spectra were used to identify alpha particles from the decay of Rn-222, Po-218, Rn-220 and Po-216. This study found that (22 +/- 2)% of Po-218 progeny (from Rn-222 decay) are produced with no net charge in 40 Torr CS2. For Po-216 progeny (from Rn-220 decay) the uncharged fraction is (100 +0 ...

International Nuclear Information System (INIS)

Carbothermal reduction-nitridation (CRN) of SiO_2 is an attractive method for manufacturing Si_3N_4 powders with controlled grain morphology. Moreover, #beta#-sialon powders could also be synthesized from either pure powder mixtures or some inexpensive raw minerals by CRN. The resultant powders have shown some advantages, especially in manufacturing sialon products at low cost. However, there have been only a few works on preparing #alpha#-sialon powders. In this work, Ca-#alpha# sialon powder was synthesized by CRN of a SiO_2-Al_2O_3 and CaCO_3 powder mixture An unusual morphology of hollow balls of 200 to 500nm with many nano size #alpha#-sialon particles of 10 to 30nm was identified from the resultant Ca-#alpha# sialon powders. This has never been previously reported for sialon ceramics. It was consequently confirmed that the morphologies of the products were clearly related to the intermediate ...

Energy Technology Data Exchange (ETDEWEB)

The fluorescent behaviour and the photodynamic effect was studied in native and structurally modified lysozyme and ..cap alpha..-lactalbumin. The Tyr residues in lysozyme and ..cap alpha..-lactalbumin show different sensitivities to the photodynamic effect. The effect is zero in the case of Tyr from native lysozyme. In contrast, the Tyr residues in ..cap alpha..-lactalbumin are susceptible to photooxidation, which indicates a greater degree of exposure to the solvent. The three His residues of ..cap alpha..-lactalbumin have different degrees of exposure and show two different kinetics of photooxidation whereas the His residue of lysozyme is photooxidized with a single kinetic. Two photooxidation kinetics were obtained for the Trp residues of both native proteins, an indication that in both cases there are Trp residues that are differently exposed to the solvent. The wavelengths of maximum fluorescent ...

Energy Technology Data Exchange (ETDEWEB)

Excitation functions ({alpha},3n) and ({alpha},4n) for {sup 209}Bi have been measured up to 60 MeV {alpha}-particle energy. The excitation functions are measured at 15{alpha}-particle energies by a stack foil technique in two steps. Excitation functions for the above two reactions have been reported for the first time in the energy range from 40 to 60 MeV. The measured experimental values are compared with the geometry-dependent hybrid (GDH) model in which the emission of particles prior to the equilibrium decay is taken into account whenever the interaction of projectile with the target nucleus is considered. It is found that the compound nucleus decay mechanism alone is unable to explain the experimental trend of our data. The initial exciton number 4 with different configurations has been tested and it is concluded that the configuration (2n + 2p + 0h) gives the best fit to the experimental data. ...

International Nuclear Information System (INIS)

The formation of the melilite solid solution phase (M'), Sm_2Si_3_-_xAl_xO_3_+_xN_4_-_x, in an #alpha#-sialon sample of overall composition Sm_0_._6Si_9_._2_8Al_2_._6_9O_1_._3_6N_1_4_._7_6, was studied as a function of time in the temperature interval 1,375--1,525 C. The #alpha#-sialon ceramic contained only minor amounts of the 21R sialon polytype and some residual grain-boundary glass before heat treatment. In situ studies by high-temperature X-ray diffraction were combined with postsintering heat treatment followed by quenching. The M'-phase was found to be formed by two different mechanisms: either crystallization of the residual grain-boundary liquid or a direct decomposition of the #alpha#-sialon phase. The liquid crystallized during the first 10--15 min of heat treatment, yielding a rapid M'-phase formation, and further formation of M'-phase continued at a much slower rate, related to the decomposition of ...

Energy Technology Data Exchange (ETDEWEB)

The K0.5 for intracellular sodium of the two forms of (Na ,K )-ATPase which exist in rat adipocytes has been determined by incubating the cells in the absence of potassium in buffers of varying sodium concentration; these conditions shut off the Na pump and allow sodium to equilibrate into the cell. The activity of (Na ,K )-ATPase was then monitored with YWRb /K pumping which was initiated by adding isotope and KCl to 5 mM, followed by a 3-min uptake period. Atomic absorption and SSNa tracer equilibration were used to determine the actual intracellular (Na ) under the different conditions. The K0.5 values thus obtained were 17 mM for alpha and 52 mM for alpha(+). Insulin treatment of rat adipocytes had no effect on the intracellular (Na+) nor on the Vmax of YWRb /K pumping, but did produce a shift in the sodium ion K0.5 values to 14 mM for alpha and 33 mM for alpha(+). This change in affinity can ...

Energy Technology Data Exchange (ETDEWEB)

Blood flow changes in the periodontal ligament (PDL) were measured indirectly by monitoring the local clearance of /sup 125/I/sup -/ during electric sympathetic nerve stimulation or close intra-arterial infusions of either noradrenaline (NA) or adrenaline (ADR) before and after administration of phentolamine (PA), phenoxybenzamine (PBZ) or Idazoxan (RX). At the doses used in the present study, PA was the only antagonist that significantly reduced the blood flow decrease seen on activation of sympathetic fibers, although PBZ also reduced this response. Idazoxan, however, did not induce the consistent effect on blood flow decreases seen on sympathetic activation. All three ..cap alpha..-adrenoceptor antagonists almost abolished the effects of exogenously administered NA and ADR. The results suggest the presence of functional post-junctional adrenoceptors of both the ..cap alpha.. 1 and ..cap alpha.. 2 subtypes in the ...

CERN Document Server

The spectral properties of Lyman break galaxies (LBGs) offer a means to isolate pure samples displaying either dominant Ly-alpha in absorption or Ly-alpha in emission using broadband information alone. We present criteria developed using a large z ~ 3 LBG spectroscopic sample from the literature that enables large numbers of each spectral type to be gathered in photometric data, providing good statistics for multiple applications. In addition, we find that the truncated faint, blue-end tail of z ~ 3 LBG population overlaps and leads directly into an expected Ly-alpha emitter (LAE) population. As a result, we present simple criteria to cleanly select large numbers of z ~ 3 LAEs in deep broadband surveys. We present the spectroscopic results of 32 r' <~ 25.5 LBGs and r' <~ 27.0 LAEs at z ~ 3 pre-selected in the Canada-France-Hawaii Telescope Legacy Survey that confirm these criteria.

International Nuclear Information System (INIS)

The inducible transcription factor NF-#kappa#B regulates divergent signaling pathways including inflammatory response and cancer development. Selective inhibitors for NF-#kappa#B signaling are potentially useful for treatment of inflammation and cancer. NF-#kappa#B is canonically activated by preferential disposal of its inhibitory protein; I#kappa#B, which suppresses the nuclear translocation of NF-#kappa#B. I#kappa#B#alpha# (a major member of I#kappa#B family proteins) is phosphorylated with an I#kappa#B kinase (IKK) and subsequently polyubiquitylated by SCF"#beta#"T"r"C"P"1 ubiquitin-ligase in the presence of E1 and E2 prior to proteasomal degradation. Here, we describe a novel inhibitor termed GS143, which suppressed I#kappa#B#alpha# ubiquitylation, but not I#kappa#B#alpha# phosphorylation, MDM2-directed p53 ubiquitylation, and proteasome activity in vitro. GS143 markedly suppressed the destruction of ...

International Nuclear Information System (INIS)

A single round of Edman degradation was employed to remove the NH_2-terminal valine from isolated #alpha# chains of human hemoglobin. Reconstitution of normal #beta# chains with truncated or substituted #alpha# chains was used to form truncated (des-Val"1-#alpha#1) and substituted ([[1-"1"3C]Gly"1]#alpha#1) tetrameric hemoglobin analogs. Structural homology of the analogs with untreated native hemoglobin was established by using several spectroscopic and physical methods. Functional studies indicate that the reconstituted tetrameric protein containing des-Val"1-#alpha# chains has a higher affinity for oxygen, is less influenced by chloride ions or 2,3-biphosphoglycerate, and shows lower cooperativity than native hemoglobin. These results confirm the key functional role of the #alpha#-chain NH_2 terminus in mediating cooperative oxygen binding across the dimer ...

Energy Technology Data Exchange (ETDEWEB)

The pharmacology of the alpha-2 adrenoceptor of the human adipocyte was improved by using some new alpha-2 antagonists from different chemical families (imidazolines, benzazepines and benzofuroquinolizines) in biological and binding assays. Moreover, investigations were also carried out to define the binding properties of a new imidazolinic antagonist, RX821002 (2-(2-methoxy-1,4-benzodioxan-2yl)-2-imidazoline), which could be a potential radioligand. (3H)RX821002 binding was very rapid and reversible. Saturation isotherms indicated that (3H)RX821002 labeled, with high affinity, a homogeneous population of noninteracting binding sites with a mean Kd of 0.98 +/- 0.05 nM (n = 6). The binding of (3H)RX821002 on the human fat cell alpha-2 adrenoceptor displayed a specificity which is strictly similar to that obtained with (3H)rauwolscine and which is classical for an alpha-2 A adrenoceptor. The binding ...

International Nuclear Information System (INIS)

A review of the ALPHA project is presented, including a summary of progress and current status. The project comprises the experimental and analytical investigation of the long-term decay heat removal phenomena from the containment of the next generation of ''passive'' Advanced Light Water Reactors. The effects of aerosols that may result from hypothetical severe accidents are also considered. The construction of the major ALPHA experimental facilities, PANDA, LINX-2 and AIDA, has been completed. First steady-state tests have been performed on PANDA. The other facilities are now in their commissioning phases. Scaling studies have guided the design of the experimental facilities. Several small-scale experimental and studies have already produced valuable results which can be used to direct the experimental work, as well as the design of the passive ALWRs. (author). 23 refs, 6 figs.

International Nuclear Information System (INIS)

We have computed the next-next-to-leading order QCD corrections to the Gross-Llewellyn Smith sum rule for deep inelastic neutrino-nucleon scattering and to the Bjorken sum rule for polarized electron-nucleon scattering. This involved the proper treatment of #gamma#_5 inside the loop integrals within dimensional regularization. We find that the difference between the two sum rules are entirely due to a class of six three-loop graphs and is of the order of 1% of the leading QCD term (O(#alpha#_s)). Hence the Q"2 behavior of both sum rules should be nearly the same if the physics is described adequately by the lower order terms of perturbative QCD. (orig.).

International Nuclear Information System (INIS)

Thermohydrogen treatment effect on microstructure and mechanical properties is studied for a cast heat resistant pseudo-#alpha#-titanium alloy Ti-6242 (Ti-6Al-2Sn-4Zn-2Mo) widely used as a heat resistant material with operating temperature up to 500 deg C. It is shown that reversible hydrogen alloying is a promising alternative to thermomechanical treatment for transformation of (#alpha#+#beta#)-titanium alloy structure. The application of thermohydrogen treatment is noted to be of particular efficiency for shaped casting technology as it allows a noticeable increase of mechanical properties at a lower cost. The alloy after thermohydrogen treatment and subsequent heat treatment in the (#alpha#+#beta#) - range possesses high values of yield strength fatigue properties, creep resistance and has a satisfactory ductility. A consideration is also given to thermohydrogen treatment effect on fatigue crack propagation and impact ...

Energy Technology Data Exchange (ETDEWEB)

Over the last several years considerable concern has been expressed regarding the potential detrimental effects of radon and radon progeny on our health. The complex nature of the radon decay scheme, which involves the emission of a variety of radiations including several [alpha] particles, [beta] particles, and [gamma]-rays, does not lend itself to clear delineation of the biological effects of the [alpha] particles alone. Polonium-210, the terminal radionuclide of the radon decay series, is useful for this purpose because it has a relatively long shelf-life ([tau][sub 1/2] = 138 d), and it only emits a single 5.3 MeV [alpha] particle in its decay to stable [sup 206]Pb. Accordingly, it has been used extensively in radiobiological studies with incorporated radionuclides. The radionuclide [sup 210]Po is produced in a reactor from [sup 209]Bi. (Author).

International Nuclear Information System (INIS)

The #beta#-CEZ alloy : Ti-5%Al-2%Sn-4%Zr-4%Mo-2%Cr-1%Fe is a near #beta# titanium alloy. Since its processing routes include heat treatment (consisting of solution treatment and ageing), it has been decided to study the influence of the #beta# phase stability on #alpha# phase precipitation and hardening kinetics. Small sized specimens, coming from industrial heats, have been heat treated above and below the #beta# transus, and then water quenched. Therefore, several degree of #beta# stability are obtained. When it is increased (i.e. the solution treatment temperature is lowered), #alpha# or #omega# phases precipitations are delayed, as well as the hardening phenomena. Moreover, the #omega# stability domain is reduced. The mechanisms of #alpha# or #omega# precipitation are discussed, and related to the hardening kinetics. (orig.).

Energy Technology Data Exchange (ETDEWEB)

Protein kinase C activity has been identified in the rat brown adipocyte. About 60% of this activity is found in the cytosolic fraction under basal conditions, and 12-O-tetradecanoylphorbol 13-acetate (TPA) causes a rapid shift from the cytosol to the particulate fraction. Norepinephrine and phenylephrine causes a similar redistribution that can be blocked by prazosin but not by alprenolol. {alpha}{sub 1}-Adrenergic agonists cause three- to fivefold stimulation of type 2 iodothyronine 5{prime}-deiodinase activity in brown adipocytes. TPA has no effect on basal deiodinase activity and reduces the response of the enzyme to {alpha}{sub 1}-adrenergic agonists. These results suggest that the translocation of protein kinase C from cytosol to particulate fraction is not sufficient to increase deiodinase activity but can modulate the {alpha}{sub 1}-adrenergic agonist-mediated responses in these cells.

CERN Document Server

A new constraint of clustering for the AMD calculation is proposed. This new constraint gives us large improvement in studying the cluster structure by AMD which sometimes meets difficulty in giving rise to some specific cluster configurations. The usefulness of this new constraint is verified by applying it to the the study of the third $K^\\pi = 0^+$ band of $^{20}$Ne which has been discussed to have $2\\alpha$-$^{12}$C structure. This band has not been easy even to construct by AMD. We see that the AMD+GCM calculation by the use of the new constraint gives rise to the third $K^\\pi = 0^+$ band which contains the $2\\alpha$-$^{12}$C structure as an important component.

International Nuclear Information System (INIS)

The X-ray intensity ratio K_#beta#/K_#alpha# has been measured by using a 10 mCi "5"5Fe source (Mn K X-rays) and high resolution Si(Li) detector system coupled to a computer-controlled multichannel analyzer over the range of 15#<=#Z#<=#22. Correction have been made to the measured relative intensities (K_#alpha# and K_#beta# X-rays) for self-absorption in the sample, air, Be-window absorption and detection efficiency. The results are compared with those of other experiments and with the Scofield calculations. (author) 13 refs.; 3 figs.; 2 tabs.

International Nuclear Information System (INIS)

K-shell x-ray production cross sections and K#beta#/K#alpha# ratios have been measured for thin targets of Ti, V, Cr, Fe, Ni, Cu, Zn, Ga, As, Se, Rb, Sr, and Y for 0.5- to 2.5-MeV alpha particles. The experimental values are compared to the nonrelativistic plane-wave Born approximation (PWBA), the binary-encounter approximation, and the PWBA with binding energy and Coulomb deflection corrections. The PWBA with corrections provides the best agreement with the experimental cross sections.

International Nuclear Information System (INIS)

#alpha#/#beta# sialon based composites containing silicon nitride whisker and silicon carbide platelet were fabricated by hot pressing. Effect of the reinforcing agents on the #alpha# to #beta# phase transformation of the sialon as well as on the mechanical properties was investigated. Silicon nitride whisker and silicon carbide platelet promoted the phase transformation. TEM/EDS analysis revealed that the grain containing the whisker had 'core-rim' structure; core being high purity Si_3N_4 whisker and rim being #beta#-sialon. Flexural strength of the composite decreased with the reinforcement addition which, on the other hand, improved fracture toughness of it. High temperature strength was measured at 1300 deg C to be about 130 MPa lower than that measured at RT for the whisker reinforced composite. (author).

Energy Technology Data Exchange (ETDEWEB)

The electronic structure of small niobium clusters Nb/sub n/ (n = 2, 4, 6, 9) has been calculated applying two different quantum-chemical approximation methods (Extended Hueckel (EH) method; SW-X/sub alpha/ method). It was found that both the methods led to the same results concerning equilibrium structures, energy level schemes, Fermi energies and band widths as well as the densities of states of the clusters. In solving solid state problems of transition metals with the aid of the cluster model a better adaptation of the EH method should be expected by adjusting the EH parameters to the SW-X/sub alpha/ results.

International Nuclear Information System (INIS)

Ionizing radiations that differ in number, size, and distribution of energy deposition events might be expected to cause different effects for the same absorbed dose. Furthermore, microdosimetry calculations suggest that large variations in biological effectiveness might be expected for internally deposited alpha-emitting radionuclides for the same absorbed dose, depending upon the specific activity and spatial distribution of the sources in tissue. The study described in this article was designed to demonstrate these phenomena in vitro. Cultured Chinese hamster ovary (CHO-K1 BH4) cells were exposed in vitro to inert, insoluble ceramic microspheres in zirconium dioxide labeled with "2"3"9Pu. The average exit energy of the 5.15 MeV alpha particle was calculated to be 4.3 MeV. Exposure times varied from four to seven hours to achieve the desired dose level.