nadh antagonistic effects: Topics by WorldWideScience.org

The opposite effect of bivalent cations on cytochrome b5 reduction by NADH:cytochrome b5 reductase and NADPH:cytochrome c reductase.

Full Text Available

2009-12-01

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Succession of Indigenous Pseudomonas spp. and Actinomycetes on Barley Roots Affected by the Antagonistic Strain Pseudomonas fluorescens DR54 and the Fungicide Imazalil

The effects of bivalent cations on cytochrome b5 reduction by NADH:cytochrome b5 reductase and NADPH:cytochrome c reductase were studied with the proteinase-solubilized enzymes. Cytochrome b5 reduction...Full Text Available

1988-05-01

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Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice

In recent years, the interest in the use of bacteria for biological control of plant-pathogenic fungi has increased. We studied the possible side effects of coating barley seeds with the antagonistic...Full Text Available

2001-03-01

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TNF-alpha antagonist therapy modify the tuberculin skin test response

OBJECTIVENicotinamide adenine dinucleotides (NAD⁺ and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD⁺-to-NADH ratio is implicated...Full Text Available

2009-04-01

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British Library Electronic Table of Contents (United Kingdom)

Tumour necrosis factor-alpha (TNF-?) antagonist drugs have been associated with increased risk of tuberculosis (TB). Tuberculin skin test (TST) is the most frequently used tool for identification of latent TB infection. We herein aimed to analyse the effect of TNF-? antagonists on the TST responses in a prospective study. The study group consisted of 182 patients (99 female, 83 male) who received TNF-? antagonists for various rheumatic disorders. All patients were evaluated with TST along with other parameters on the day of referral and on the 12th month visit. For those patients with a response of <5?mm induration at the initial evaluation, the TST was repeated to observe the booster effect. Out of 182 patients, 87 patients (48%) had a negative (0?4?mm) and 95 (52%) had a positive (?5?mm)...

2011-01-01

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Primaquine

Role of intrathecal tachykinins for micturition in unanaesthetized rats with and without bladder outlet obstruction.

... oxygen to the tissues in the body),nicotinamide adenine dinucleotide (NADH) deficiency (a genetic condition), glucose-6- ...

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Effects of the cannabinoid antagonist SR141716 (rimonabant) and d-amphetamine on palatable food and food pellet intake in non-human primates

1. The effects on micturition of RP 67,580, a selective NK1 receptor antagonist, and SR 48,968, a highly, potent antagonist at NK2 receptor sites, given intrathecally (i.t.) or intra-arterially (i.a.)...Full Text Available

1994-09-01

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Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-d-aspartate receptors

The purpose of this study was to determine if a cannabinoid CB₁ receptor antagonist would selectively decrease consumption of highly palatable food in non-human primates. The CB₁...Full Text Available

2007-04-01

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British Library Electronic Table of Contents (United Kingdom)

The synthesis and structure-activity relationship analysis of a novel class of amide-based biaryl NR2B-selective NMDA receptor antagonists are presented. Some of the studied compounds are potent, selective, non-competitive, and voltage-independent antagonists of NR2B-containing NMDA receptors. Like the founding member of this class of antagonists (ifenprodil), several interesting compounds of the series bind to the amino terminal domain of the NR2B subunit to inhibit function. Analogue potency is modulated by linker length, flexibility, and hydrogen bonding opportunities. However, unlike previously described classes of NR2B-selective NMDA antagonists that exhibit off-target activity at a variety of monoamine receptors, the compounds described herein show much diminished effects against the...

2009-01-01

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Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice

Brg1 Is Required for Cdx2-Mediated Repression of Oct4 Expression in Mouse Blastocysts

Both deficiency and excess of growth hormone (GH) are associated with increased mortality and morbidity. GH replacement in otherwise healthy subjects leads to complications, whereas individuals with...Full Text Available

2010-12-21

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Antidepressant-Like Effects of ?-Opioid Receptor Antagonists in Wistar Kyoto Rats

During blastocyst formation the segregation of the inner cell mass (ICM) and trophectoderm is governed by the mutually antagonistic effects of the transcription factors Oct4 and Cdx2. Evidence indicates...Full Text Available

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Reversible Inactivation of Nitrate Reductase by NADH and the Occurrence of Partially Inactive Enzyme in the Wheat Leaf 1

The Wistar Kyoto (WKY) rat strain is a putative genetic model of comorbid depression and anxiety. Previous research showing increased κ-opioid receptor (KOR)...Full Text Available

2010-02-01

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Impaired mitochondrial energy metabolism and kinetic properties of cytochrome oxidase following acute aluminium phosphide exposure in rat liver

Nitrate reductase from wheat (Triticum aestivum L. cv Bindawarra) leaves is inactivated by pretreatment with NADH, in the absence of nitrate, a 50% loss of activity occurring in 30...Full Text Available

1983-03-01

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British Library Electronic Table of Contents (United Kingdom)

The present study was designed with an aim to analyze the effect of acute aluminium phosphide (ALP) exposure (10mg/kg b.wt, intragastrically) on the kinetic characteristics of cytochrome oxidase and energy metabolism in male Wistar rat liver mitochondria. Liver mitochondrial preparations from ALP-treated rats exhibited significant decrease (66%) in the activity of cytochrome oxidase suggesting that there was a decrease in the catalytic efficiency of the active oxidase molecules on ALP treatment. The decreased activity of cytochrome oxidase with altered NADH and succinic dehydrogenase activities might have contributed towards a significant decline in state 3 and state 4 respiration as observed. These alterations in the electron transport chain complexes in turn adversely affected the ATP sy...

2010-01-01

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Effect of the GnRH antagonist, acyline, on canine testicular characteristics.

Reinforcing Effects of ?-Receptor Agonists in Rats Trained to Self-Administer Cocaine

The primary objective was to assess the effects and clinical safety of a single high-dose of the third generation GnRH antagonist, acyline, on testicular characteristics in male dogs. Seven dogs were followed up weekly for six, 2-week periods (-2, -1, 1, 2, 3 and 4). At the end of the second period, they were given acyline (330 microg/kg sc). Responses to treatment varied among individual animals. Testicular consistency and scrotal diameter were slightly diminished (P>0.05) in Periods 1, 2, and 3. Libido and erection decreased during Periods 1 and 2 (Pdecreased semen quality with no adverse effects. PMID:17586037

2007-06-21

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Effects of the. cap alpha. -adrenoceptor antagonists phentolamine, phenoxybenzamine, and Idazoxan on sympathetic blood flow control in the periodontal ligament of the cat

σ-Receptor (σR) antagonists have been reported to block certain effects of psychostimulant drugs. The present study examined the effects of σR ligands in rats trained to self-administer...Full Text Available

2010-02-01

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Effects of the cannabinoid antagonist SR141716 (rimonabant) and d-amphetamine on palatable food and food pellet intake in non-human primates

Blood flow changes in the periodontal ligament (PDL) were measured indirectly by monitoring the local clearance of /sup 125/I/sup -/ during electric sympathetic nerve stimulation or close intra-arterial infusions of either noradrenaline (NA) or adrenaline (ADR) before and after administration of phentolamine (PA), phenoxybenzamine (PBZ) or Idazoxan (RX). At the doses used in the present study, PA was the only antagonist that significantly reduced the blood flow decrease seen on activation of sympathetic fibers, although PBZ also reduced this response. Idazoxan, however, did not induce the consistent effect on blood flow decreases seen on sympathetic activation. All three ..cap alpha..-adrenoceptor antagonists almost abolished the effects of exogenously administered NA and ADR. The results suggest the presence of functional post-junctional adrenoceptors of both the ..cap alpha.. 1 and ..cap alpha.. 2 ...

1988-01-01

18

British Library Electronic Table of Contents (United Kingdom)

The purpose of this study was to determine if a cannabinoid CB1 receptor antagonist would selectively decrease consumption of highly palatable food in non-human primates. The CB1 receptor antagonist SR141716 (rimonabant; 0.12?1.0?mg/kg, i.m.) and the stimulant anorectic drug d-amphetamine (0.12?1.0?mg/kg, i.m.) were administered to non-food deprived baboons for the purpose of measuring the effect of each drug on consumption of the normal diet, and a large single meal of a high-carbohydrate candy. Four male and four female baboons had access to food 24?h each day, but they had to complete a two phase operant procedure in order to eat. Responding on one lever during a 30-min appetitive phase was required before animals could start a consumption phase, where responding on another lever led to...

2007-01-01

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Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys

Quantitative RT-PCR Expression Analysis of Lipodepsipeptides Synthetase and Defence-related Genes in Orange Fruit in Response to Antagonist-pathogen Interaction

Dopamine (DA) D3 and D2 receptor mechanisms are implicated in cocaine's abuse-related behavioral effects, but the relative contribution of the two receptor subtypes is only partially characterized....Full Text Available

2010-08-01

20

British Library Electronic Table of Contents (United Kingdom)

Abstract Strains of Pseudomonas syringae are effective in controlling postharvest diseases of citrus fruits, and antagonistic activity has been correlated with in vitro production of lipodepsipeptides. Additionally, biocontrol agents can induce a range of defence mechanisms of resistance in citrus tissue that result in a broad spectrum of metabolic modifications, such as systemic acquired resistance, induced systemic resistance and production of reactive oxygen species. The aim of this study was to evaluate the expression of syringomycin (syrB1) and syringopeptin (sypA) synthetase genes from P.syringae pv. syringae biocontrol strains in vitro on different culture media and in vivo on citrus fruits (Citrus sinensis cv. Tarocco) during the interaction with Penicillium digitatum by quantitati...

2011-01-01

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Inflammatory spine disease as a cause of back pain

In vivo modulation of murine serum tumour necrosis factor and interleukin-6 levels during endotoxemia by oestrogen agonists and antagonists.

The aim of this review is to evaluate the role of inflammatory spine disease in patients with chronic back pain. The contribution of imaging modalities for the diagnostic evaluation of back pain is discussed. A systematic literature search based on the classification of seronegative spondyloarthropathies and rheumatoid arthritis was performed. The results of this search and the experiences in a large collective of rheumatological patients are analyzed. The prevalence of rheumatoid arthritis (1-2%) is comparable to that of spondyloarthropathies (1.9%). The etiology of these entities is not fully elucidated. Magnetic resonance imaging is increasingly used for early detection and surveillance of therapy with TNF-#alpha# antagonists. Bone marrow edema, which is only detectable with MRI, represents an early sign of inflammation. Therapy with TNF-#alpha# antagonists is based on clinical and laboratory criteria, and signs of inflammation in MRI. MRI ...

2006-06-01

22

Discrimination between UTP- and P2-purinoceptor-mediated depolarization of rat superior cervical ganglia by 4,4'-diisothiocyanatostilbene-2,2'- disulphonate (DIDS) and uniblue A.

Oestrogen has been reported to modulate tumour necrosis factor (TNF), interleukin (IL)-1 and IL-6 cytokine levels in human mononuclear cell cultures. In the present study, the effects of exogenous oestrogen...Full Text Available

1995-09-01

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Microsomal Electron Transfer in Higher Plants: Cloning and Heterologous Expression of NADH-Cytochrome b₅ Reductase from Arabidopsis

1. Using a grease-gap recording technique we have investigated the effects of some antagonists of P2-purinoceptors on the depolarization of the rat isolated superior cervical ganglion evoked by 100...Full Text Available

1995-06-01

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Rubidium uptake by mouse pancreatic islets exposed to 6-hydroxydopamine, ninhydrin, or other generators of hydroxyl radicals

AtCBR, a cDNA encoding NADH-cytochrome (Cyt) b₅ reductase, and AtB5-A and AtB5-B, two cDNAs encoding Cyt b₅, were isolated from Arabidopsis....Full Text Available

1999-01-01

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Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms

The purpose was to study the toxicity of drugs known to generate free radicals on isolated pancreatic islets. The accumulattion of "8"6Rb"+ by mouse pancreatic islets was measured in vitro. Exposing the islets to 6-hydroxydopamine, minhydrin, or phenazine methosulphate + NADH inhibited the Rb"+ uptake, whereas paraquat or acetylphenylhydrazine had no effect. This effect of 6-hydroxydopamine was prevented by either of the hydroxyl radical scavengers, sodium benzoate and mannitol, but not by the non-scavenger,urea; ninhydrin was partially protected against by mannitol but not by benzoate. Protection against 6-hydroxydopamine was also afforded by D-glucose but not by L-glucose or 3-O-methyl-D-glucose; none of the sugars protected against ninhydrin. In damaging islet beta-cells and in being protected against by D-glucose, 6-hydroxydopamine closely resembles the diabetogenic drug, alloxan. It is suggested that protection against ...

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Low-level microwave irradiations affect central cholinergic activity in the rat

The widespread use of tobacco and alcohol among adolescents might be related to the ability of nicotine and ethanol to facilitate social interactions. To investigate the neurobehavioral mechanisms underlying the prosocial effects of nicotine and ethanol, we focused on social play behavior, the most characteristic social activity in adolescent rats. Social play behavior is rewarding, and it is modulated through opioid, cannabinoid and dopaminergic neurotransmission, which are also involved in the reinforcing properties of nicotine and ethanol. We found that nicotine and ethanol increased social play, without affecting locomotion or social exploration. Their effects depended on the level of social activity of the partner, and were comparable in familiar and unfamiliar environments. At doses that increased social play, nicotine and ethanol had no anxiolytic effects in the elevated plus-maze. By contrast, the prototypical ...

2009-08-05

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Afferent mechanisms of microwave-induced biological effects. Annual report, 1 June 1985-31 May 1986

Sodium-dependent high-affinity choline uptake was measured in various regions of the brains of rats irradiated for 45 min with either pulsed or continuous-wave low-level microwaves (2,450 MHz; power density, 1 mW/cm2; average whole-body specific absorption rate, 0.6 W/kg). Pulsed microwave irradiation (2-microseconds pulses, 500 pulses/s) decreased choline uptake in the hippocampus and frontal cortex but had no significant effect on the hypothalamus, striatum, and inferior colliculus. Pretreatment with a narcotic antagonist (naloxone or naltrexone; 1 mg/kg i.p.) blocked the effect of pulsed microwaves on hippocampal choline uptake but did not significantly alter the effect on the frontal cortex. Irradiation with continuous-wave microwaves did not significantly affect choline uptake in the hippocampus, striatum, and hypothalamus but decreased the uptake in the frontal cortex. The ...

1987-01-01

28

Aging, tumor suppression and cancer: High-wire act!

Effects of 2450-MHz circularly polarized microwave irradiation on central nervous system functions were studied. Pulsed (microsecond, 500 pps) microwaves decreased high-affinity sodium-dependent choline uptake in the hippocampus and frontal cortex of the rat. The effect on hippocampal choline uptake was blocked by pretreatment with narcotic antagonists. Continuous-wave microwaves of the same power density decreased choline uptake in the frontal cortex only. Furthermore, it was found that the effects of pulsed microwaves on central cholinergic activity are classically conditionable to cues in the exposure environment. The hypothesis that some of the neurological effects of pulsed microwave irradiation are caused by its effect on the auditory system was investigated. Effects of pink noise and pulsed microwaves were compared.

1986-07-01

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Pyridine Nucleotide Specificity of Barley Nitrate Reductase ¹

Evolutionary theory holds that aging is a consequence of the declining force of natural selection with age. We discuss here the evidence that among the causes of aging in complex multicellular organisms, such as mammals, is the antagonistically pleiotropic effects of the cellular responses that protect the organism from cancer. Cancer is relatively rare in young mammals, owing in large measure to the activity of tumor suppressor mechanisms. These mechanisms either protect the genome from damage and/or mutations, or they elicit cellular responses--apoptosis or senescence--that eliminate or prevent the proliferation of somatic cells at risk for neoplastic transformation.We focus here on the senescence response, reviewing its causes, regulation and effects. In addition, we describe recent data that support the idea that both senescence and apoptosis may indeed be the double-edged swords predicted by the evolutionary hypothesis ...

2004-08-15

30

Biochemical Characterization of Soybean Mutants Lacking Constitutive NADH:Nitrate Reductase ¹

NADPH nitrate reductase activity in higher plants has been attributed to the presence of NAD(P)H bispecific nitrate reductases and to the presence of phosphatases capable of hydrolyzing NADPH to NADH....Full Text Available

1982-05-01

31

Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc.

Two nitrate reductase (NR) mutants were selected for low nitrate reductase (LNR) activity by in vivo NR microassays of M₂ seedlings derived from nitrosomethylurea-mutagenized...Full Text Available

1986-06-01

32

Anti-muscarinic actions of mitoxantrone in isolated heart muscles of guinea pigs.

Endoreduplication represents a cell cycle variant during which multiple rounds of DNA replication occur without subsequent chromosome separation and cytokinesis, resulting into a cellular increase of the DNA content. Although the DNA ploidy level of cells is controlled by external stimuli such as light, currently limited knowledge is available on how environmental signals regulate the endoreduplication cycle at the molecular level. Previously, we have demonstrated that the conversion from the mitotic cell cycle into an endoreduplication cycle is mediated by the atypical E2F transcription factor DEL1 that operates as a repressor of endocycle onset. Here, we identified DEL1 as a transcriptional target of the classical E2Fb and E2Fc transcription factors that antagonistically control DEL1 transcript levels through competition for a single E2F cis-acting binding site. Correspondingly with the reported opposite effect of light on the E2Fb and E2Fc ...

2011-09-01

33

Environmental analysis of endocrine disrupting effects from hydrocarbon contaminants in the ecosystem. 1997 annual progress report

A hypotheses that mitoxantrone is a competitive antagonist at muscarinic cholinergic receptors was examined in guinea-pig hearts. In isolated left atrial muscle preparations, electrically paced at 2 Hz, the muscarinic agonist, carbachol, caused a concentration-dependent decrease in developed tension. Mitoxantrone caused a parallel right-ward shift of the concentration-response curve for carbachol. Schild plots for the effect of mitoxantrone on the carbachol concentration-response relationship were linear with a slope of 0.88 which was not significantly different from the unity. The right-ward shift of the carbachol concentration-response relationship by mitoxantrone significantly reversed after an additional incubation with a mitoxantrone-free solution, although the reversal was incomplete after a 2-h incubation in the mitoxantrone-free solution. Mitoxantrone caused a concentration-dependent displacement of specific [3H]quinuclidinyl benzilate ...

2000-10-27

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ProteoChip-based Library Screening of Integrin ${\\alpha}5{\\beta}1$ Antagonists from Korean Medicinal Plant Extracts

'The overall objective of the basic research grant is to characterize the potential of common hydrocarbon contaminants in ecosystems to act as endocrine disruptors. The three major lines of research include (1) a biotechnology based screening system to identify potential hormone mimics and antagonists; (2) an animal screening system to identify biomarkers of endocrine effects. and (3) a literature review to identify compounds at a variety of DOE sites that need to be examined for endocrine disrupting effects. By relating results obtained from this research project to contamination problems at various DOE sites. CBR will provide data and information on endocrine disrupting contaminants to DOE for consideration in risk analyses for determining clean-up levels and priorities needed at the sites.'

1997-01-01

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Comparison of Microbial Fungicides in Antagonistic Activities Related to the Biological Control of Phytophthora Blight in Chili Pepper Caused by Phytophthora capsici

Full Text Available

2007-12-01

36

Helminthosporium maydis T toxin decreased calcium transport into mitochondria of susceptible corn

Full Text Available

2010-12-01

37

Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosterone

The effects of purified Helminthosporium maydis T (HmT) toxin on active Ca/sup 2 +/ transport into isolated mitochondria and microsomal vesicles were compared for a susceptible (T) and a resistant (N) strain of corn (Zea mays). ATP, malate, NADH, or succinate could drive /sup 45/Ca/sup 2 +/ transport into mitochondria of corn roots. Ca/sup 2 +/ uptake was dependent on the proton electrochemical gradient generated by the redox substrates or the reversible ATP synthetase, as oligomycin inhibited ATP-driven CA/sup 2 +/ uptake while KCN inhibited transport driven by the redox substrates. Purified native HmT toxin completely inhibited Ca/sup 2 +/ transport into T mitochondria at 5 to 10 nanograms per milliliter while transport into N mitochondria was decreased slightly by 100 nanograms per milliliter toxin. Malate-driven Ca/sup 2 +/ transport in T mitochondria was frequently more inhibited by 5 nanograms per milliliter toxin than succinate or ...

1984-04-01

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DEFF Research Database (Denmark)

Aldosterone has been suggested to elicit vessel contraction via a nongenomic mechanism. We tested this proposal in microdissected, perfused rabbit renal afferent arterioles. Aldosterone had no effect on internal diameter in concentrations from 10(-10) to 10(-5) mol/L, but aldosterone abolished the ability of 100 mmol/L KCl to induce vascular contraction. The inhibitory effect of aldosterone was observed from 1 pmol/L. The inhibitory effect was significant after 5 minutes and maximal after 20 minutes and was fully reversible. Actinomycin D (10(-6) mol/L) prolonged the effect of aldosterone. The effect was abolished by the mineralocorticoid receptor antagonist spironolactone (10(-7) mol/L) but not by the glucocorticoid receptor antagonist mifepristone (10(-6) mol/L). The K+-mediated increase of intracellular calcium concentration in afferent ...

2003-01-01

39

Mitochondrial NADH:ubiquinone oxidoreductase (complex I) in eukaryotes: A highly conserved subunit composition highlighted by mining of protein databases

British Library Electronic Table of Contents (United Kingdom)

Complex I (NADH:ubiquinone oxidoreductase) is the largest enzyme of the mitochondrial respiratory chain. Compared to its bacterial counterpart which encompasses 14-17 subunits, mitochondrial complex I has almost tripled its subunit composition during evolution of eukaryotes, by recruitment of so-called accessory subunits, part of them being specific to distinct evolutionary lineages. The increasing availability of numerous broadly sampled eukaryotic genomes now enables the reconstruction of the evolutionary history of this large protein complex. Here, a combination of profile-based sequence comparisons and basic structural properties analyses at the protein level enabled to pinpoint homology relationships between complex I subunits from fungi, mammals or green plants, previously identified...

2011-01-01

40

Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli

British Library Electronic Table of Contents (United Kingdom)

2-methylpropan-1-ol (isobutanol) is a leading candidate biofuel for the replacement or supplementation of current fossil fuels. Recent work has demonstrated glucose to isobutanol conversion through a modified amino acid pathway in a recombinant organism. Although anaerobic conditions are required for an economically competitive process, only aerobic isobutanol production has been feasible due to an imbalance in cofactor utilization. Two of the pathway enzymes, ketol-acid reductoisomerase and alcohol dehydrogenase, require nicotinamide dinucleotide phosphate (NADPH); glycolysis, however, produces only nicotinamide dinucleotide (NADH). Here, we compare two solutions to this imbalance problem: (1) over-expression of pyridine nucleotide transhydrogenase PntAB and (2) construction of an NADH-de...

2011-01-01

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Radiolabelled D2 agonists as prolactinoma imaging agents

Unraveling photosystems. Final technical report

During the past year, further studies on mAChR were conducted. These studies included verification of the difference in pituitary distribution based on ligand charge. The pituitary localization of TRB. A neutral mAChR ligand, was verified. The lack of QNB blockade of TRB uptake was tested by blockage with scopolamine, another mAChR antagonist and by testing the effect in a different strain of rat. Neither scopolamine or change of rat strain had any effect. We concluded that TRB uptake in pituitary is not a receptor-mediated process. Further studies were conducted with an additional quaternized mAChR ligand: MQNB. Pituitary localization of MQNB, like MTRB, could be blocked by pretreatment with QNB. We have tentatively concluded that permanent charge on a mAChR antagonist changes the mechanism of uptake in the pituitary. Time course studies and the effects of DES on myocardial uptake ...

1989-08-01

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Effect of systemic blockade of ?(1)-noradrenergic receptors on sex behavior and vaginal-cervical stimulation-induced Fos in female rats.

This report highlights four main points. (1) A residue substitution in phosphoribulokinase of Synechocystis PCC 6803 renders the mutant light-sensitive. The authors isolated a light-sensitive mutant (BRLS) of the photosynthetic cyanobacterium Synechocystis 6803 that does not survive exposure to bright light; 70% of BRLS cells die upon exposure to light of > 3000 lux for 2 hr. (2) Excitation energy transfer from phycocyanin to chlorophyll in an apcA-defective mutant of Synechocystis sp. PCC 6803. A greenish mutant of the normally bule-green cyanobacterium Synechocystis sp. PC 6803, designated UV6p, was isolated and characterized. UV6p possesses functional photosystems I and II but lacks normal light harvesting phycobilisomes because allophycocyanin is absent and core-specific linker proteins are almost entirely absent. (3) Deletion of the psbG1 gene of the cyanobacterium Synechocystis sp. PCC 6803 leads to the activation of the cryptic psbG2 gene. The genes psbG1 and psbG2 in ...

1997-09-01

43

CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression

It is hypothesized that systemic ??-noradrenergic antagonists may interfere with the transmission of sensory stimulation, particularly vaginal--cervical stimulation (VCS), which is crucial for reproductive functioning. To determine if ??-noradrenergic transmission receptor activity is necessary for transmission of sensory information important for VCS-dependent events, we conducted an experiment using prazosin, a ??-noradrenergic receptor antagonist. First, three doses of prazosin (1.0, 0.5 or 0.1 mg/kg) or the 10% ETOH in sesame oil vehicle were administered i.p. and sexual receptivity was assessed 30 min later in ovariectomized, hormone-treated female rats. The 1 mg/kg dose of prazosin significantly inhibited lordosis quotients and lordosis ratings. This dose of prazosin (1.0 mg/kg) was then administered 30 min prior to VCS or control scapular stimulation (CSS) and Fos-IR was examined in the posterodorsal medial amygdala (MeaPD), the medial ...

2010-10-01

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British Library Electronic Table of Contents (United Kingdom)

Genome-wide association studies have linked lung cancer risk with a region of chromosome 15q25.1 containing CHRNA3, CHRNA5 and CHRNB4 encoding a3, a5 and b4 subunits of nicotinic acetylcholine receptors (nAChR), respectively. One of the strongest associations was observed for a non-silent single-nucleotide polymorphism at codon 398 in CHRNA5. Here, we have used pharmacological (antagonists) or genetic (RNA interference) interventions to modulate the activity of CHRNA5 in non-transformed bronchial cells and in lung cancer cell lines. In both cell types, silencing CHRNA5 or inhibiting receptors containing nAChR a5 with a-conotoxin MII exerted a nicotine-like effect, with increased motility and invasiveness in vitro and increasing calcium influx. The effects on motility were enhanced by addit...

2011-01-01

45

Transformation of Verapamil by Cunninghamella blakesleeana

Theoretical and practical considerations on the problem of metal--metal interaction.

A filamentous fungus, Cunninghamella blakesleeana AS 3.153, was used as a microbial model of mammalian metabolism to transform verapamil, a calcium channel antagonist. The metabolites...Full Text Available

2004-05-01

46

Regulation of Senescence in Cancer and Aging

The interaction between two metals, which can be either synergistic or antagonistic, implies that the behavior of one is changed by the presence of the other. Possible mechanisms of these interactions,...Full Text Available

1978-08-01

47

Protracted ethanol withdrawal in rats: Tolerance to the anxiolytic effects of diazepam and pentobarbital but not phenobarbital

Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically...Full Text Available

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A Phase III Extension Trial With a 1-Arm Crossover From Leuprolide to Degarelix: Comparison of Gonadotropin-Releasing Hormone Agonist and Antagonist Effect on Prostate Cancer

Anxiety is a common symptom during ethanol withdrawal contributing to its continuous abuse and alcoholism. Ethanol withdrawal in rats produces an interoceptive discriminative stimulus (IDS) similar to that produced by the anxiogenic drug pentylenetetrazol (PTZ). This stimulus peaks at 12 hours after last dose of ethanol and thereafter the IDS is detected for several days (protracted withdrawal) by sensitization to a probe drug. previously, the authors have shown that during the protracted withdrawal, the IDS is enhanced by GABA receptor antagonists suggesting alteration of brain GABA systems. This report provides further evidence that chronic ethanol alters GABAergic systems. Rats were trained to discriminate PTZ (20 mg/kg, ip) from saline. Diazepam, pentobarbital and phenobarbital blocked the PTZ-IDS dose dependently. Ethanol, 4.5% w/v, was then given in a nutritionally complete diet for a week. On termination of the ethanol diet, rats exhibited signs and symptoms ...

1990-02-26

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British Library Electronic Table of Contents (United Kingdom)

PurposeWe investigated the efficacy and safety of degarelix treatment and the effects of switching from leuprolide to degarelix in an ongoing extension study with a median 27.5-month followup of a pivotal 1-year prostate cancer trial. Materials and MethodsPatients who completed a 1-year pivotal phase III trial continued on the same monthly degarelix maintenance dose (160 or 80 mg in 125 each), or were re-randomized from leuprolide 7.5 mg to degarelix 240/80 mg (69) or 240/160 mg (65). Data are shown on the approved degarelix 240/80 mg dose. The primary end point was safety/tolerability and the secondary end points were testosterone, prostate specific antigen, luteinizing hormone and follicle-stimulating hormone responses, and prostate specific antigen failure and progression-free survival....

2011-01-01

50

Disruption of contact inhibition in rat liver epithelial cells by various types of AhR ligands

A randomized trial of microdose leuprolide acetate protocol versus luteal phase ganirelix protocol in predicted poor responders

The maintenance of a balance between cell gain and cell loss is essential for proper liver function. The exact role of aryl hydrocarbon receptor (AhR) in regulating cell proliferation and apoptosis of liver cells remains unclear, since ligand-dependent activation of AhR has been shown to induce cell cycle arrest, proliferation, differentiation or apoptosis, depending on the cellular model used. AhR can directly interact with retinoblastoma protein in hepatic cells, forming protein complexes that can efficiently block cell cycle progression by inducing G1 arrest, or to induce the expression of inhibitors of cyclin-dependent kinases, such as p271. On the other hand, it has been suggested that AhR could play a stimulatory role in cell proliferation, either directly or by mediating a release from contact inhibition. It is now generally accepted that progenitor cells exist in the liver, are activated in various liver diseases and can form a potential target cell population for both tumor ...

2004-09-15

51

British Library Electronic Table of Contents (United Kingdom)

We performed a randomized trial to compare IVF outcomes in 54 poor responder patients undergoing a microdose leuprolide acetate (LA) protocol or a GnRH antagonist protocol incorporating a luteal phase E2 patch and GnRH antagonist in the preceding menstrual cycle. Cancellation rates, number of oocytes retrieved, clinical pregnancy rates (PR), and ongoing PRs were similar between the two groups.

2011-01-01

52

Short-term regulation of muscarinic acetylcholine receptors: An assessment utilizing mouse brain and mouse neuroblastoma cells

Selective metabolic stimulation of the subfornical organ and pituitary neural lobe by peripheral angiotensin II

The effects of muscarinic agonists and diisopropylfluorophosphate (DFP) on muscarinic receptor density and muscarinic receptor-mediated responses was assessed in mouse brain and mouse neuroblastoma cells (clone N1E-115). Utilizing the antagonist ({sup 3}H)quinuclidinyl benzilate (({sup 3}H)QNB), there was no difference in the maximal binding capacity (B{sub max}) or equilibrium dissociation constant (K{sub d}) between untreated and 24 hour DFP-treated mice. However, one administration of DFP produced a 24% and 33% decrease in B{sub max} measured by ({sup 3}H)N-methylscopolamine (({sup 3}H)NMS) after 18 and 24 hours which was rapidly reversible within 36 hours after DFP treatment. The loss of ({sup 3}H)NMS binding sites following acute DFP treatment was not accompanied by a change in a particular muscarinic receptor binding conformation. Furthermore, the magnitude of muscarinic receptor-mediated phosphoinositide hydrolysis was unchanged ...

1988-01-01

53

Characterization of the xanthine-binding site on R/sub a/ and R/sub i/ subtypes of the adenosine receptor

The subfornical organ is a major receptor area for one of the principal stimuli of thirst, the octapeptide, angiotensin II. In conscious water-sated rats, the authors examined the effects of intravenous infusion of angiotensin II on the rate of glucose utilization in the subfornical organ and in structures anatomically and functionally connected with it. Angiotensin II produced pressor and drinking responses and increased glucose utilization selectively in the subfornical organ and pituitary neural lobe and in no other brain structure. Treatment with the angiotensin II antagonist, sar1-leu8-angiotensin II, before intravenous administration of angiotensin II prevented metabolic stimulation of the subfornical organ and neural lobe. Captopril, an inhibitor of angiotensin-converting enzyme, reduced subfornical organ glucose metabolism to a level similar to that found in control animals. These results demonstrate that peripheral angiotensin II ...

1985-01-01

54

Inflammatory spine disease as a cause of back pain; Entzuendliche Wirbelsaeulenerkrankungen als Ursache fuer Rueckenschmerzen

Methylxanthines and their derivatives are antagonists at cell surface adenosine receptors. They report here a systematic study of xanthine structure-activity relationships which compares potency at two adenosine receptor subtypes, R/sub a/ and R/sub i/. Adenylate cyclase stimulation (R/sub a/ in platelet membranes) and inhibition (R/sub i/ in adipocyte membranes) were used as models of receptor activation. K/sub i/ values were obtained by Schild analysis. The orders of potency of the xanthines to attenuate the effects of adenosine analogues were similar to those previously reported. Earlier work utilizing radioligand binding (R/sub i/ and (/sup 3/H) cAMP formation (R/sub a/) claimed that IIX and PACPX are at least 10 and 400 fold, respectively, more potent at R/sub i/ than at R/sub a/. However, in their assays which utilize modulation of receptor-coupled adenylate cyclase, the xanthines show little specificity for either adenosine receptor ...

1986-05-01

55

Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

The aim of this review is to evaluate the role of inflammatory spine disease in patients with chronic back pain. The contribution of imaging modalities for the diagnostic evaluation of back pain is discussed. A systematic literature search based on the classification of seronegative spondyloarthropathies and rheumatoid arthritis was performed. The results of this search and the experiences in a large collective of rheumatological patients are analyzed. The prevalence of rheumatoid arthritis (1-2%) is comparable to that of spondyloarthropathies (1.9%). The etiology of these entities is not fully elucidated. Magnetic resonance imaging is increasingly used for early detection and surveillance of therapy with TNF-{alpha} antagonists. Bone marrow edema, which is only detectable with MRI, represents an early sign of inflammation. Therapy with TNF-{alpha} antagonists is based on clinical and laboratory criteria, and signs of inflammation in MRI. MRI ...

2006-06-15

56

beta. -Endorphin and related peptides suppress phorbol myristate acetate-induced respiratory burst in human polymorphonuclear leukocytes

Anthraquinones are widely present in plant kingdom, and clinically used as laxatives. Environmental contaminants, dioxins, develop various adverse effects through transformation of a cytosolic aryl hydrocarbon receptor (AhR). We investigated the effects of 18 anthraquinones and 7 of their structurally related compounds on transformation of the AhR estimated by its DNA-binding activity in the cell-free system. 1,4-Dihydroxyanthraquinone (quinizarin), 1,5-dihydroxyanthraquinone (anthrarufin), 1,8-dihydroxyanthraquinone (danthron), and 5-hydroxy-1,4-naphthoquinone (juglone) strongly suppressed DNA-binding activity of the AhR induced by 0.1 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), with their IC(50) values around 1 muM. On the other hand, anthraquinone, 2,6-dihydroxyanthraquinone (anthraflavic acid), and 2-hydroxy-1,4-naphthalendione (lawsone) showed moderate effects. Quantitative structure-activity relationships analysis ...

2009-03-01

57

In vitro competitive adhesion and production of antagonistic compounds by lactic acid bacteria against fish pathogens

In the present study, the immunomodulatory effect of {beta}-endorphin ({beta}-E) and shorter pro-opiomelancortin (POMC) fragments was evaluated by assessing their influence on respiratory burst in human polymorphonuclear leukocytes (PMN). The effect of the peptides on phorbol myristate acetate (PMA)-stimulated production of reactive oxygen metabolites was measured in a lucigenin-enhanced chemiluminescence (CL) assay. Both POMC peptides with opiate-like activity and their non-opioid derivatives were tested. With the exception of {alpha}-E, PMA-stimulated respiratory burst was suppressed by all POMC fragments tested. A U-shaped dose-response relation was observed. Doses lower than 10{sup {minus}17}M and higher than 10{sup {minus}8}M were without effect. {beta}-E and dT{beta}E both suppressed PMA-induced oxidative burst in human PMN at physiological concentrations. {gamma}-E and dT{gamma}E proved to be less potent inhibitors, ...

1989-01-01

58

British Library Electronic Table of Contents (United Kingdom)

The present study describes the screening of five lactic acid bacteria (LAB) for use as probiotics based on their competitive adhesion and production of antagonistic substances against some fish pathogens. A reduction of adhesion of all pathogenic strains tested was obtained with three of the LAB strains (Lactococcus lactis subsp. lactis CLFP100, Lactococcus lactis subsp. cremoris CLFP102 and Lactobacillus curvatus CLFP150). With the exception of fish pathogens Flavobacterium psychrophilum and Renibacterium salmoninarum that were not inhibited by LAB strains, production of antagonistic compounds by all tested LAB was observed against at least one of the indicator strains. Based on mucus adhesion, competitive exclusion, and suppression of fish pathogen growth, the selected LAB strains can b...

2007-01-01

59

Assessing radiologic risk for population due to human activities

The stereospecificity of LY253352 for alpha 1-adrenoceptor binding sites in the brain and prostate.

The most important factor in assessing radiologic risk is ensuring scientific means for evaluation of the radioactive release impact upon humans and organisms. To evaluate quantitatively this impact not only knowledge of radioactivity distribution in these dynamical systems is necessary but also understanding the transfer mechanisms between ecosystem components is needed. Thus a complete radioecologic study appear to be very complex and needs defining the source term, dynamic description of radionuclides behavior in the ecosystem, estimation of radiation doses in the major components of the ecosystem and finally the effects of radiation doses upon different parts of the systems. A diagram of the steps implied in evaluation of the effects due to radioactive effluent release in the environment is presented and discussed. The following steps are described: - identification of radioactive sources, as well as their input rate. Presence of noxious ...

2002-09-06

60

Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene

1. The stereospecificity of the enantiomers of LY253352, a potent and selective alpha 1-adrenoceptor antagonist, were studied in the human prostate and canine brain using radioligand receptor binding...Full Text Available

1988-09-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

61

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn

Selective estrogen receptor modulators (SERMs) represent a class with a growing number of compounds that act as either estrogen receptor agonists or antagonists in a tissue-specific manner. This article...Full Text Available

2010-01-01

62

RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice

The neonatal Fc receptor FcRn provides IgG molecules with their characteristically long half-lives in vivo by protecting them from intracellular catabolism and then returning them to...Full Text Available

2008-02-19

63

Progressive ratio performance following challenge with antipsychotics, amphetamine, or NMDA antagonists in adult rats treated perinatally with phencyclidine

BackgroundGlucocorticoids down-regulate cytokine synthesis and suppress inflammatory responses. The glucocorticoid receptor (GR) antagonist RU486 may exacerbate the inflammatory...Full Text Available

64

Pharmacokinetics and tolerability of zibotentan (ZD4054) in subjects with hepatic or renal impairment: two open-label comparative studies

RationalePrevious research has shown that rats exposed perinatally to phencyclidine (PCP) exhibited neuroanatomical abnormalities and altered cognition. In addition...Full Text Available

2004-12-01

65

Novel Analogs and Stereoisomers of the Marine Toxin Neodysiherbaine with Specificity for Kainate Receptors

BackgroundZibotentan (ZD4054) is a specific endothelin A (ET_A) receptor antagonist being investigated for the treatment of prostate cancer. As zibotentan is eliminated...Full Text Available

66

Misreporting of myocardial infarction end points: results of adjudication by a central clinical events committee in the PARAGON-B trial. Second Platelet IIb/IIIa Antagonist for the Reduction of Acute Coronary Syndrome Events in a Global Organization Network Trial.

Antagonists for kainate receptors (KARs), a family of glutamate-gated ion channels, are efficacious in a number of animal models of neuropathologies, including epilepsy, migraine pain, and anxiety....Full Text Available

2008-02-01

67

Micturition in conscious rats with and without bladder outlet obstruction: role of spinal alpha 1-adrenoceptors.

PMID:11835026

2002-02-01

68

Human placental transport of cimetidine.

1. In normal rats and rats with bladder hypertrophy secondary to outflow obstruction, undergoing continuous cytometry, we examined the responses to the selective alpha 1-adrenoceptor antagonist doxazosin...Full Text Available

1996-03-01

69

Cardiovascular Safety of Degarelix: Results From a 12-Month, Comparative, Randomized, Open Label, Parallel Group Phase III Trial in Patients With Prostate Cancer

This study addresses the mechanism of transport of the H2-receptor antagonist, cimetidine, by the human placenta. A 4-h recycling perfusion of a single placental cotyledon of normal, term, human placenta...Full Text Available

1987-11-01

70

Antagonistic crosstalk between APC and HIF-1?

PurposeWe assessed the cardiovascular safety profile of degarelix, a new gonadotropin-releasing hormone antagonist.Materials...Full Text Available

2010-12-01

71

Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast

Most colorectal cancers have mutations in the tumor suppressor APC. The best-understood function of APC is its participation in a protein complex that regulates the availability of β-catenin....Full Text Available

2011-05-15

72

Antagonist HIV-1 Gag Peptides Induce Structural Changes in HLA B8

BackgroundHistone post-translational modifications are critical for gene expression and cell viability. A broad spectrum of histone lysine residues have been identified in yeast...Full Text Available

73

Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1? Have an Antagonistic Connection

In the cellular immune response, recognition by CTL-TCRs of viral antigens presented as peptides by HLA class I molecules, triggers destruction of the virally infected cell (Townsend, A.R.M., J. Rothbard,...Full Text Available

1996-12-01

74

A population pharmacokinetic meta-analysis of maraviroc in healthy volunteers and asymptomatic HIV-infected subjects

The tumor suppressor adenomatous polyposis coli (APC) is mutated in the majority of colorectal cancers and is best known for its role as a scaffold in a Wnt-regulated protein complex that determines...Full Text Available

2010-11-01

75

Effects of opioid peptides on thermoregulation

AimsTo develop a population pharmacokinetic model for maraviroc, a noncompetitive CCR5 antagonist, after oral administration of tablets to healthy volunteers and asymptomatic HIV-infected...Full Text Available

2008-04-01

76

B chain is a functional subunit of beta-bungarotoxin for inducing apoptotic death of human neuroblastoma SK-N-SH cells.

In a given species, injected opioid peptides usually cause changes in temperature similar to those caused by nonpeptide opioids. The main effect in those species most studied, the cat, rat, and mouse, is an increase in the level about which body temperature is regulated; there is a coordinated change in the activity of thermoregulatory effectors such that hyperthermia is produced in both hot and cold environments. Larger doses may depress thermoregulation, thereby causing body temperature to decrease in the cold. Elicitation of different patterns of response over a range of environmental temperatures and studies with naloxone and naltrexone indicate that stimulation of a number of different receptors by both peptide and nonpeptide opioids can evoke thermoregulatory responses. ..beta..-Endorphin is readily antagonized by naloxone whereas methionine-enkephalin can act on naloxone-insensitive receptors. Moreover, synthetic peptide analogs do not necessarily evoke the ...

1981-11-01

77

Studies on the mechanism of action of enterotoxin-induced fluid secretion in the gut

beta-Bungarotoxin (beta-Bgt), a presynaptic phospholipase A(2) (PLA(2)) neurotoxin isolated from the venom of Bungarus multicinctus, consists of A chain and B chain. The goal of the present study is to explore the functional contribution of the two subunits to the toxicity of beta-Bgt. beta-Bgt was found to induce apoptotic death of SK-N-SH cells via elevating intracellular Ca(2+) and intracellular ROS production. Moreover, an activation of p38 MAPK was associated with the cytotoxicity of beta-Bgt. SB202190 (p38 MAPK inhibitor), N-acetylcysteine (antioxidant reagent), 1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid (BAPTA) (Ca(2+) chelator) and the inhibitors of Ca(2+) release from intracellular depots (ruthenium red and 2-aminoethoxydiphenyl borate) effectively attenuated the cytotoxicity of beta-Bgt. In sharp contrast to the inability of A chain, B chain was able to induce cytotoxic effects on SK-N-SH cells as beta-Bgt did. Abolishment ...

2007-10-13

78

Uncoupling action of polychlorinated biphenyls (Kanechlor-400) on oxidative phosphorylation in rat liver mitochondria

The mechanism of action of Clostridium difficile enterotoxin A (CA), of Escherichia coli enterotoxin (STa) and of cholera toxin (CT), which are known to cause severe diarrhea, were studied in a preparation of ligated jejunal loops of anesthetized rats in vivo. The toxins were administered intraluminally. Pharmacological agents, which were tested for their potency to influence toxin-related effects, were administered subcutaneously. Net fluid transport was determined gravimetrically, prostaglandin (PG) E_2-output into the lumen, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) contents in the mucosa were measured by radioimmunoassay, serotonin-(5-HT)-output into the lumen was determined by high performance liquid chromatography. The histopathological effects of CA and CT were examined by light- and scanning electron microscopy. All three toxins caused net fluid secretion (FS). 5-HT_2-(ketanserin) and ...

1992-01-01

79

Involvement of a glutamergic mechanism in gamma-dendrotoxin-induced hippocampal neuronal cell loss in the rat.

A study was made of the uncoupling action of polychlorinated biphenyls (Kanechlor-400) on oxidative phosphorylation in rat liver mitochondria. Kanechlor-400 (KC-400) at 20 ..mu..g/ml stimulated state 4 respiration of rat liver mitochondria more than 4-fold with ..cap alpha..-ketoglutarate/malate as a substrate, and released the oligomycin-inhibited state 3 respiration. KC-400 also dissipated the membrane potential across the mitochondrial membranes; thus, it acts as an uncoupler of oxidative phosphorylation in rat liver mitochondria. KC-400 altered the permeability properties of mitochondrial membranes as evidenced by the release of endogenous K/sup +/ and the oxidation of exogenously supplied NADH. It is concluded that KC-400 produces a nonspecific increase in mitochondrial ion permeability, thereby dissipating membrane potential, which leads to the uncoupling.

1984-03-01

80

Contribution of calcium ions and hydrogen ions to the signal transduction chain in phytochrome-mediated spore germination. [Onoclea sensibilis L

The epileptogenic and neurodegenerative effects of gamma-dendrotoxin, from Dendroaspis angusticeps, a specific blocker of a non-inactivating, voltage-sensitive K+ channel, were studied after focal injection into one dorsal hippocampus in rats pretreated with CGP040116, a N-methyl-D-aspartate (NMDA) receptor antagonist, and in rats bearing a monolateral surgical lesion of the Schaffer collaterals whose terminals originate from CA3 pyramids and release glutamate in the CA1 hippocampal area. Administration of 35 pmol gamma-dendrotoxin elicited in all of the treated animals (n=8) bilateral EEG discharges and damage to the hippocampal formation. Quantitation of the damage revealed significant bilateral neuronal cell loss in the CA1, CA3 and CA4 pyramidal cell layers. The lowest dose (0.35 pmol; n=4) of the toxin used did not affect EEG activity and failed to cause significant hippocampal cell loss whereas the 3.5 pmol (n=6) dose caused EEG seizures ...

2004-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

81

Time-resolved confocal fluorescence spectroscopy reveals the structure and metabolic state of epithelial tissue

Red light stimulates germination in the spores of Onoclea sensibilis L. Phytochrome is confirmed to be the photoreceptor pigment in the germination response by demonstrating red-far-red photoreversibility. External Ca/sup 2 +/ is required for this response with a threshold at a submicromolar concentration. Red light stimulates an increase in the total concentration of intracellular calcium in the spores as determined by atomic absorption spectroscopy. Subsequent exposure to far-red light inhibits the red light-induced increase in intracellular calcium. The majority of the increase occurs 5 minutes after the onset of irradiation. The calcium-antagonist, La/sup 3 +/ inhibits both germination and the red light-induced increase in intracellular calcium. Using /sup 31/P-nuclear magnetic resonance spectroscopy, the author tested the hypothesis that a sustained increase in intracellular pH contributes to the signal transduction chain. He never detected a red light-induced ...

1985-01-01

82

Novel high-throughput screening system for identifying STAT3-SH2 antagonists

Autofluorescence spectroscopy has been a widely explored technique for in vivo and noninvasive diagnosis of pre-cancer lesions in epithelium where 90% cancers originate. For extracting more accurate fluorescence information for cancer diagnosis, depth-resolved fluorescence measurements are crucial to assess NADH and FAD in non-keratinized epithelial layer and collagen in stromal layer, respectively. In this study, we achieved the depth-resolved fluorescence spectral measurements of squamous epithelial tissue based on confocal technique. We found that in non-keratinized epithelial layer the fluorescence signals excited at 405 nm were the combination of NADH and FAD fluorescence and could be used for evaluating the redox ratio. Moreover, we found that confocal time-resolved autofluorescence measurements of epithelial tissue with 405 nm excitations could provide the information on the layered tissue structure. All depth-resolved autofluorescence ...

2007-03-01

83

Kinetic manifestation of cooperative interaction between quinuclidinyl benzilate and rat brain muscarine cholinoreceptors

Constitutive activation of the oncogenic transcription factor STAT3 frequently occurs in various human malignancies. STAT3 activation involves dimerization via intermolecular pTyr-SH2 interaction. Thus, antagonizing this interaction is a feasible approach to inhibit STAT3 activation for cancer therapy. In order to identify selective STAT3 inhibitors, we developed a biochemical HTS system based on AlphaScreen technology, which measures the abilities of test compounds to antagonize pTyr-SH2 interactions. We screened our chemical libraries using this system and identified 5,15-diphenylporphyrin (5,15-DPP) as a selective STAT3-SH2 antagonist. Selective inhibition of STAT3 nuclear translocation and DNA biding activity was observed in cells treated with 5,15-DPP. IL-6-dependent dimerization of STAT3, c-myc promoter binding and c-myc protein expression were all suppressed by 5,15-DPP, whereas no decrement in either expression or phosphorylation level of STAT3 was ...

2009-03-13

84

The (--)(/sup 3/H)dihydroalprenolol binding to rat adipocyte membranes: an explanation of curvilinear Scatchard plots and implications for quantitation of beta-adrenergic sites

A study was made of the kinetics of L-(/sup 3/H)quinuclidinyl benzilate binding with membrane-bound muscarine cholinoreceptors from the rat brain. Determination was made of the rate constants of this process, and constants as a function of ligand concentration was investigated, indicating that there is a complex mechanism of interaction of antagonists with muscarine receptor. With up to 3.5 nM concentrations of L-(/sup 3/H)quinuclidinyl benzilate, the binding reaction occurs in two stages: rapid equilibrated binding is followed by a slow process of conformational isomerization of the receptor-ligand complex. At higher ligand concentrations, there is additional drastic increase in constant of rate of ligand binding a new plateau is reached. Such dependence of rate constant on ligand concentration is indicative of the cooperative nature of interaction between antagonists and muscarine receptors. This is possible if there are in the receptor ...

1985-01-01

85

New tools for human fat cell alpha-2A adrenoceptor characterization. Identification on membranes and on intact cells using the new antagonist (3H)RX821002

In rat adipocyte membranes, both beta-adrenergic agonists and beta-adrenergic antagonists competed with (--)(/sup 3/H)dihydroalprenolol for high affinity (KD 2-4 nM) and low capacity binding sites. The antagonists but not the agonists competed with (--)(/sup 3/H)dihydroalprenolol for lower affinity and higher capacity sites. The present studies were performed in order to characterize the adipocyte beta-adrenergic receptor and distinguish it from low affinity, higher capacity sites which were heat-labile and not stereoselective. When isoproterenol was used to define the nonspecific binding, saturation studies showed a single binding site with a capacity of approximately 100 fmol/mg membrane protein (corresponding to approximately 50,000 sites/adipocyte). Binding was saturated by 10 nM (--)(/sup 3/H)dihydroalprenolol. Approximate KD's of 204 nM were observed. Kinetic analysis of (--)(/sup 3/H)dihydroalprenolol binding provided an ...

1982-09-01

86

Characterization of histamine H_1-receptor binding peptides in guinea pig brain using ["1"2"5I]iodoazidophenpyramine, an irreversible specific photoaffinity probe

The pharmacology of the alpha-2 adrenoceptor of the human adipocyte was improved by using some new alpha-2 antagonists from different chemical families (imidazolines, benzazepines and benzofuroquinolizines) in biological and binding assays. Moreover, investigations were also carried out to define the binding properties of a new imidazolinic antagonist, RX821002 (2-(2-methoxy-1,4-benzodioxan-2yl)-2-imidazoline), which could be a potential radioligand. (3H)RX821002 binding was very rapid and reversible. Saturation isotherms indicated that (3H)RX821002 labeled, with high affinity, a homogeneous population of noninteracting binding sites with a mean Kd of 0.98 +/- 0.05 nM (n = 6). The binding of (3H)RX821002 on the human fat cell alpha-2 adrenoceptor displayed a specificity which is strictly similar to that obtained with (3H)rauwolscine and which is classical for an alpha-2 A adrenoceptor. The binding parameters of (3H)RX821002 were compared with ...

1990-01-01

87

Characterization of a Novel Small Molecule Subtype Specific Estrogen-Related Receptor ? Antagonist in MCF-7 Breast Cancer Cells

Aminophenpyramine, a derivative of mepyramine (pyrilamine), a typical antagonists of histamine at its H_1 receptor was synthesized and converted into ["1"2"5I]iodoazidophenpyramine, a potential photoaffinity probe for the H_1 receptor. In the dark, reversible binding of this probe to cerebellar membranes occurred with a K/sub d/ of 1.2 x 10"-"1"1 M and a B/sub max/ of 240 fmol/mg of protein and was inhibited by various H_1-receptor antagonists with the expected potencies. These features establish the compound as one of the most potent H_1-receptor antagonists known so far. Upon IV irradiation, 5% of the bound radioactivity was covalently incorporated into cerebellar membrane polypeptides as shown by standard NaDodSO_4/PAGE. Two bands of 47 and 56 kDa were consistently labeled, labeling being prevented by various H_1-receptor antagonists with the expected potencies and stereoselectivity. In the presence ...

88

Blockade of catecholamine-induced growth by adrenergic and dopaminergic receptor antagonists in Escherichia coli O157:H7, Salmonella enterica and Yersinia enterocolitica

BackgroundThe orphan nuclear receptor estrogen-related receptor α (ERRα) is a member of the nuclear receptor superfamily. It was identified through a search for genes...Full Text Available

89

Ophidian envenomation strategies and the role of purines.

BackgroundThe ability of catecholamines to stimulate bacterial growth was first demonstrated just over a decade ago. Little is still known however, concerning the nature of the putative...Full Text Available

90

Design of a new serotonin receptor 5-HT_1_A imaging agent based on "9"9"mTc

Snake envenomation employs three well integrated strategies: prey immobilization via hypotension, prey immobilization via paralysis, and prey digestion. Purines (adenosine, guanosine and inosine) evidently play a central role in the envenomation strategies of most advanced snakes. Purines constitute the perfect multifunctional toxins, participating simultaneously in all three envenomation strategies. Because they are endogenous regulatory compounds in all vertebrates, it is impossible for any prey organism to develop resistance to them. Purine generation from endogenous precursors in the prey explains the presence of many hitherto unexplained enzyme activities in snake venoms: 5'-nucleotidase, endonucleases (including ribonuclease), phosphodiesterase, ATPase, ADPase, phosphomonoesterase, and NADase. Phospholipases A(2), cytotoxins, myotoxins, and heparinase also participate in purine liberation, in addition to their better known functions. Adenosine contributes to prey immobilization ...

2002-04-01

91

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

Serotonin is one of the neurotransmitters found in the brain and mediates brain functions. It is very well known that serotonin related brain abnormalities are exerted mainly via serotonin receptors in a similar manner to other neurotransmitters found in the brain. Recently, it has also been found that serotonin is involved in Alzheimer's disease either directly or indirectly by its actions on serotonergic neurons. To understand and treat the diseases caused by abnormalities in the serotonergic system in the brain, it is certain that its mechanism of function has to be well investigated. So far several 5-HT receptors and receptor subtypes have been well characterized. Moreover, serotonin agonists and antagonists acting on specific receptors are chemically synthesized and are now available for the prevention or treatment of serotonergic related diseases. In recent years, a great demand for developing neuroimaging agents has emerged for the diagnosis of abnormal ...

2004-07-01

92

Developments of PET radioligands for NMDA receptors

Myostatin is a member of the transforming growth factor-{beta} (TGF-{beta}) family and a strong negative regulator of muscle growth. Here, we present the crystal structure of myostatin in complex with the antagonist follistatin 288 (Fst288). We find that the prehelix region of myostatin very closely resembles that of TGF-{beta} class members and that this region alone can be swapped into activin A to confer signalling through the non-canonical type I receptor Alk5. Furthermore, the N-terminal domain of Fst288 undergoes conformational rearrangements to bind myostatin and likely acts as a site of specificity for the antagonist. In addition, a unique continuous electropositive surface is created when myostatin binds Fst288, which significantly increases the affinity for heparin. This translates into stronger interactions with the cell surface and enhanced myostatin degradation in the presence of either Fst288 or Fst315. Overall, we have identified ...

2009-09-29

93

Kinetics of in vivo binding of antagonist to muscarinic cholinergic receptor in the human heart studied by Positron Emission Tomography

Aim: There has been a great demand for developments of the radioligands to visualize the N-methyl-D-aspartate (NMDA) receptors by PET/SPECT. We have recently synthesized two C-11 labeled antagonists for the glycine-binding site on NMDA receptors. The aim of this work is to examine for their in vitro and in vivo binding characteristics, and to evaluate their potentials as PET radioligands for the NMDA receptors. Materials and methods: Two C-11 labeled 4-hydroxy-2-quinolones (1 and 2) were synthesized by conventional methylation of the corresponding phenols with ["1"1C]methyl iodide. In vitro and ex vivo quantitative autoradiographs with imaging plate, as well as animal PET, were employed in order to evaluate their in vitro and in vivo binding to the NMDA receptors. Results: The compound 1 showed the specific binding to rat brain slices with higher localization in the hippocampus and cerebral cortex than in the cerebellum. Both glycine ...

2002-09-01

94

In vitro assessment of the agonist properties of the novel 5-HT_1_A receptor ligand, CUMI-101 (MMP), in rat brain tissue

Positron Emission Tomography (PET) was used to analyze in vivo antagonist binding to human myocardial muscarinic cholinergic receptor. The methiodide salt of the muscarinic antagonist, quinuclidinyl benzilate (MQNB), was labeled with the positron emitter, Carbon-11, and injected intravenously to 8 normal subjects. /sup 11/C-MQNB concentration was determined in vivo in the ventricular septum from 40 cross-sectional images acquired at the same transverse level over a period of 70 minutes. In 4 subjects, various amounts of unlabeled atropine were rapidly injected at 20 minutes to study whether atropine competitively inhibited MQNB. The kinetics of binding of /sup 11/C-MQNB were not the same in vivo and in vitro. The apparent dissociation rate of /sup 11/C-MQNB in vivo was much slower (by 1 to 2 orders of magnitude) than that observed in vitro with /sup 3/H-QNB. After atropine injection, /sup 11/C-MQNB dissociated from its binding sites at a rate ...

1984-08-27

95

Reduction of cadmium toxicity to green microalga Stichococcus bacillaris by manganese

Introduction: Development of agonist positron emission tomography (PET) radioligands for the 5-HT neurotransmitter system is an important target to enable the understanding of human 5-HT function in vivo. ["1"1C]CUMI-101, proposed as the first 5-HT_1_A receptor agonist PET ligand, has been reported to behave as a potent 5-HT_1_A agonist in a cellular system stably expressing human recombinant 5-HT_1_A receptors. In this study, we investigate the agonist properties of CUMI-101 in rat brain tissue. Methods: ["3"5S]-GTP#gamma#S binding studies were used to determine receptor function in HEK (human embryonic kidney) 293 cells transfected with human recombinant 5-HT_1_A receptors and in rat cortex and rat hippocampal tissue, following administration of CUMI-101 and standard 5-HT1A antagonists (5-HT, 5-CT and 8-OH-DPAT). Results: CUMI-101 behaved as an agonist at human recombinant 5-HT_1_A receptors (pEC_5_0 9.2). However, CUMI-101 did not show agonist activity in either ...

2011-02-01

96

Histone deacetylase inhibitors and transforming growth factor-b induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells

Investigations of cadmium toxicity to microorganisms are now more concerned with the interactions of cadmium with different environmental factors and other metals. The interactions are complex and have not been thoroughly studied yet. Metal interactions may assume the form of synergism characterized by increase in toxicity, but also of antagonism in which one metal reduces the toxicity of another. Apart from cadmium interactions with such toxic metals as mercury and lead, interactions of cadmium with the essential trace elements seem to be very interesting because it has been assumed that algal cells take up cadmium by the system transporting these elements. A previous study showed that cadmium transport into Stichococcus bacillaris cells was inhibited by Mn/sup 2 +/ ions. Thus, it can be supported that there exist some possibilities of using those ions antagonistic to cadmium as counterposition. Showing those possibilities was the aim of the present paper.

1988-12-01

97

British Library Electronic Table of Contents (United Kingdom)

Histone deacetylase (HDAC) inhibitors have been actively exploited as potential anticancer agents. To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells. Detailed analyses indicated that HDAC inhibitors activated the 15-PGDH promoter-luciferase reporter construct in transfected A549 cells. A representative HDAC inhibitor, scriptaid, and its negative structural analog control, nullscript, were further evaluated at the chromatin level. Scriptaid but not nullscript induced a signific...

2006-01-01

98

Endophytic fungus Trichothecium roseum LZ93 antagonizing pathogenic fungi in vitro and its secondary metabolites

British Library Electronic Table of Contents (United Kingdom)

The endophytic fungus Trichothecium roseum LZ93 from Maytenus hookeri was found to antagonize other pathogenic fungi in vitro. To identify which compound contributed substantially to the antagonism, we fermented the strain and purified its fermentation products. Eleven compounds were obtained, including two trichothecenes, five rosenonolactones, two cardiotonic cyclodepsipeptides, and two sterols. Compound 11?-hydroxyrosenonolactone (1) was assigned according to 1D and 2D-NMR data for the first time. At the same time, the 1H and 13C-NMR assignments for 6?-hydroxyrosenonolactone (2) were revised. Of all of them, only trichothecin (6) showed strong antifungal activity. Based on our observations of the antagonistic activity and the other experimental results, we suggest that the antifungal co...

2010-01-01

99

Development of a detailed kinetic model for gasoline surrogate fuels

Capsaicin-induced avoidance behavior in the terrestrial Gastropoda Megalobulimus abbreviatus: Evidence for TRPV-1 signaling and opioid modulation in response to chemical noxious stimuli

A detailed chemical kinetic model to describe the autoignition of gasoline surrogate fuels is presented consisting of the fuels iso-octane, n-heptane, toluene, diisobutylene and ethanol. Model predictions have been compared with shock tube ignition delay time data for surrogates of gasoline over practical ranges of temperature and pressure, and the model has been found to be sensitive to both changes in temperature and pressure. Moreover, the model can qualitatively predict the observed synergistic and antagonistic non-linear blending behaviour in motor octane number (MON) for different combinations of primary reference fuels (PRFs) and non-PRFs by correlating calculated autoignition delay times from peak pressures and temperatures in the MON test to experimental MON values. The reasons for the blending behaviour are interpreted in terms autoignition chemistry. 37 refs., 11 figs., 4 tabs.

2008-08-15

100

British Library Electronic Table of Contents (United Kingdom)

The aim of this study was to measure the nociceptive response (avoidance latency) of the land snail Megalobulimus abbreviatus (N=8 in each group) after topical capsaicin exposure (0.1% and 0.5% in 20% ethanol) and to compare it to a well-studied stressful (50??C) thermal stimulus model. We also tested if ruthenium red, and capsazepine, respectively nonselective and selective TRPV1 receptor antagonists, could modify both capsaicin- and thermal-evoked responses. Finally, animals were pretreated with morphine, naloxone or morphine plus naloxone prior to capsaicin stimuli. Latencies were measured when the animal lifted its head?foot complex 1?cm from the substrate. Data were compared using ANOVA and LSD post hoc, and the Student T Test (pM. abbreviatus.

2007-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

101

The p75"N"T"R tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells

Prostaglandin (PG) E3 synthesis elicted by adrenergic stimuli in guinea-pig trachea (GPT) is mediated primarily by B2 adrenergic receptors

The p75 neurotrophin receptor (p75"N"T"R) is a death receptor which belongs to the tumor necrosis factor receptor super-family of membrane proteins. This study shows that p75"N"T"R retarded cell cycle progression by induced accumulation of cells in G0/G1 and a reduction in the S phase of the cell cycle. The rescue of tumor cells from cell cycle progression by a death domain deleted (#DELTA#DD) dominant-negative antagonist of p75"N"T"R showed that the death domain transduced anti-proliferative activity in a ligand-independent manner. Conversely, addition of NGF ligand rescued retardation of cell cycle progression with commensurate changes in components of the cyclin/cdk holoenzyme complex. In the absence of ligand, p75"N"T"R-dependent cell cycle arrest facilitated an increase in apoptotic nuclear fragmentation of the prostate cancer cells. Apoptosis of p75"N"T"R expressing cells occurred via the intrinsic mitochondrial pathway leading to a sequential caspase-9 and ...

2006-03-24

102

Prostaglandin (PG) E3 synthesis elicted by adrenergic stimuli in guinea-pig trachea (GPT) is mediated primarily by B2 adrenergic receptors

The purpose of this study was to examine arachidonic acid (AA) metabolism and to characterize the type of adrenergic receptor (AR) involved in the production of the major metabolite of this fatty acid. ({sup 14}C)AA was incubated with GPT-rings and the radiolabelled products were extracted and separated by TLC method. The medium was also assayed for radiolabelled immunoreactive PG's (iPG's) and leukotrienes (LT) B4 and C4 by RIA or Enzyme immunoassay (EIA) after exposure to various AR agonists. ({sup 14}C)AA was incorporated into GPT-rings and metabolized mainly into iPGE2 and smaller amounts into PGF2{alpha}. Trace amounts of PGD2 and 6-keto-PGF1{alpha} but not LTB4 or LTC4 were detected by RIA and/or EIA. Incubation of GPT rings for 15 minutes with isoproterenol and salbutamol resulted in a significant increase of PGE2 synthesis (optimum conc: 10{sup {minus}7}, 10{sup {minus}7}M respectively). In contrast, dobutamine, norepinephrine, phenylnephrine and xylazine (up ...

1990-02-26

103

Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy

The purpose of this study was to examine arachidonic acid (AA) metabolism and to characterize the type of adrenergic receptor (AR) involved in the production of the major metabolite of this fatty acid. ["1"4C]AA was incubated with GPT-rings and the radiolabelled products were extracted and separated by TLC method. The medium was also assayed for radiolabelled immunoreactive PG's (iPG's) and leukotrienes (LT) B4 and C4 by RIA or Enzyme immunoassay (EIA) after exposure to various AR agonists. ["1"4C]AA was incorporated into GPT-rings and metabolized mainly into iPGE2 and smaller amounts into PGF2#alpha#. Trace amounts of PGD2 and 6-keto-PGF1#alpha# but not LTB4 or LTC4 were detected by RIA and/or EIA. Incubation of GPT rings for 15 minutes with isoproterenol and salbutamol resulted in a significant increase of PGE2 synthesis (optimum conc: 10"-"7, 10"-"7M respectively). In contrast, dobutamine, norepinephrine, phenylnephrine and xylazine (up to 10"-"6M) did not significantly increase ...

1991-04-21

104

British Library Electronic Table of Contents (United Kingdom)

Aims: Serotonin (5-hydroxytryptamine 3; 5-HT3) receptors are involved in chemotherapy-induced nausea and vomiting (CINV), and 5-HT3 antagonists are part of the `gold standard' antiemetic treatment during chemotherapy. We investigated the correlation of common variants in 5-HT3 receptor subunit genes with the occurrence of CINV. Materials & methods: A total of 110 previously characterized chemotherapy-naive women with primary breast cancer treated with anthracycline-containing chemotherapy served as a study group for mutational analysis by direct sequencing. Eight common SNPs in the 5-HT3 receptor genes, HTR3A, HTR3B, HTR3D and HTR3E, were selected for association analysis. Results: A nonsynonymous variant in HTR3D, p.G36A (rs6443930), was found to be over-represented in nonresponders, assu...

2010-01-01

105

Development of gamma-emitting, receptor binding radiotracers for imaging the brain and pancreas

cap alpha. -2 adrenergic receptor: a radiohistochemical study

This progress report covers period from Nov. 1, 1989 to Aug. 31, 1990. The long term objective was to develop receptor-binding radiotracers for SPECT or PET imaging of CNS or peripheral nervous system. The specific chemistry aims, as understood on the basis of past findings, were: to synthesize and develop a more polar analogs of 4IQNB, possessing similar binding characteristics but eliminated more rapidly from the surrounding tissues and the target organ, to design a method of introducing a technetium chelating group onto a molecule or cholinergic agent without drastic lowering of its apparent affinity, to synthesize and develop radiotracers based on m-AChR antagonists selective for one of the subtypes of the receptor. The chemistry service aims were to prepare and characterize (R,R)- and (R,S)-4IQNB and derivatives, to provide the triazene intermediate to other investigators, and to provide ({sup 123}I)4IQNB for in vivo imaging. The biochemistry aims were to ...

1990-01-01

106

Radioiodination of 3-quinuclidinyl benzilate using a no-carrier-added concentration of iodine-125/sodium-iodine

..cap alpha..-2 adrenergic agents have been shown to influence blood pressure, heart rate and other physiological and behavioral functions through interactions with adrenergic pathways within the central nervous system. Pharmacologically relevant ..cap alpha..-1 adrenergic receptors were biochemically characterized and radiohistochemically analyzed in intact tissue sections of the rat and human central nervous system. The anatomical distribution of the ..cap alpha..-2 receptors, labeled with the agonist (/sup 3/H)para-aminoclonidine, verified the concept that ..cap alpha..-2 receptors are closely associated with adrenergic nerve terminals and that ..cap alpha..-2 agents can influence autonomic and endocrine function through an action in the central nervous system. Since ..cap alpha..-2 agonists can influence sympathetic outflow, ..cap alpha..-2 binding sites were closely analyzed in the intermediolateral cell column of the thoracic spinal cord. The transport of putative presynaptic ...

1984-01-01

107

Nuclear Medicine Program progress report for quarter ending September 30, 1992

3-Quinuclidinyl benzilate (QNB) is a potent muscarinic antagonist that binds to muscarinic acetylcholine receptors. Iodination of QNB is difficult because it contains rings that are deactivated, while phenol rings are activated. The purpose of this research is to develop an appropriate method for the iodination of QNB at no-carrier-added concentrations of /sup 125/I/NaI. Phenol was chose as the test compound for direct iodination by adding chloramine T and nonradioactive sodium iodide to the phenol in a phosphate buffer and methanol system. A simple method to radioiodinate QNB at several concentrations was developed in situ in the presence of QNB, thallic trifluoroacetate /sup 125/I/NaI, /sup 127/I/NaI, and aluminium chloride. Using milligram amounts of QNB (7.12 x 10/sup -6/ moles), three reaction steps were involved: QNB was reacted with thallic trifluoroacetate at 60/sup 0/C for 24 hours, then radioactive /sup 125/I/NaI and aluminium chloride were added to the ...

1986-01-01

108

Kinetic analysis of transport and opioid receptor binding of ( sup 3 H)(-)-cyclofoxy in rat brain in vivo: Implications for human studies

The radioiodination and in vivo evaluation of p-iodocaramiphen a muscarinic antagonist which binds with high affinity to the M[sub 1] receptor subtype in vitro are described. Biodistribution studies in female Fischer rats demonstrated that [[sup 125]I]-piodocaraminphen had significant cerebral localization, but the uptake did not demonstrate specific uptake in those cerebral regions rich in muscarinic receptors, and radioactivity washed out rapidly from the brain. In addition there was no significant blockage of activity when the rats were preinjected with quinuclidinyl benzilate. These results suggest that p-iodocaramiphen is not a good candidate for the in vivo study of M[sub 1] muscarinic receptor populations by SPECT. Because of the widespread interest and expected importance of the availability of large amounts of tungsten-188 required for the tungsten-188/rhenium-188 generator systems, we have investigated the large-scale production of tungsten-188 in the ...

1992-12-01

109

Cytopathic Effects of Viruses Protocols

(3H)Cyclofoxy (CF: 17-cyclopropylmethyl-3,14-dihydroxy-4,5-alpha-epoxy-6-beta-fluoromorp hinan) is an opioid antagonist with affinity to both mu and kappa subtypes that was synthesized for quantitative evaluation of opioid receptor binding in vivo. Two sets of experiments in rats were analyzed. The first involved determining the metabolite-corrected blood concentration and tissue distribution of CF in brain 1 to 60 min after i.v. bolus injection. The second involved measuring brain washout for 15 to 120 s following intracarotid artery injection of CF. A physiologically based model and a classical compartmental pharmacokinetic model were compared. The models included different assumptions for transport across the blood-brain barrier (BBB); estimates of nonspecific tissue binding and specific binding to a single opiate receptor site were found to be essentially the same with both models. The nonspecific binding equilibrium constant varied modestly in different brain ...

1991-03-01

110

Effect of Pressures up to 2.0 GPa on the Mechanical ...

Protocols for using Cytopathic Effects of Viruses

2007-09-29

111

[Effect of disulfiram on liver function].

... hydrostatic pressures up to 700 MPa. The effect of pressure on the ultimate compressive strength is shown. The effect of size on ...

112

Trust on Superiors and Organizational Effectiveness

PMID:3726630

1986-01-01

113

Irradiation effects on electronic functional materials

Full Text Available

2007-03-01

114

Irradiation effect of laser on salivary glands

No abstract prepared

1998-01-01

115

Effects and side-effects of integrating care: the case of mental health care in the Netherlands

Short communication.

1995-04-01

116

Solar wind effect on the muon flux at sea level

PurposeDescription and analysis of the effects and side-effects of integrated mental health care in the Netherlands.Context of caseDue...Full Text Available

117

Solar wind effect on the muon flux at sea level

2005-01-01

118

New Effective Pesticides

The Effect of Morpholine/Boric Acid/Hydrazine Chemistry on ...

Development the New Effective Pesticides in the Series of Pyrimine and Sym-Triazine Derivatives

119

Electromagnetic Effects Requirements for Systems.

... the effect of MBH on steam generator crevice corrosion; model boiler test results show that MBH is effective against denting corrosion and Alloy 600 ...

120

A novel procedure for assessing the effects of drugs on satiation in baboons: effects of memantine and dexfenfluramine

This standard establishes requirements, verification criteria, and contractor tasks for electromagnetic effects protection of airborne, ground, and support systems. These effects include electromagnetic compatibility, electromagnetic interference, lightni...

1993-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

121

[Occupational harmful effects in descalers and deburrers in the metallurgical industry].

RationaleProcedures for studying the effects of medications on satiation will assist the development of obesity medications.ObjectivesFull Text Available

2008-09-01

122

Thermal Effects on Thin Laser-Peened Ferritic-Martensitic Samples

PMID:5089231

1971-03-01

123

The effects of nozzle geometry on waterjet breakup at high Reynolds numbers

Abstract not provided

2007-05-17

124

The effectiveness of storage and relocation options in renewable energy systems

Not Available

2003-01-01

125

DEFF Research Database (Denmark)

Udgivelsesdato: JUL

2008-01-01

126

The Emergence of Behavioral Testing of Fishes to Measure Toxicological Effects

The Effects of Drying Conditions on the Germination Properties of Rapeseed

Full Text Available

2009-03-01

127

The Effect of Simulated Acid Rain on the Growth of Important Crops

Full Text Available

2009-02-01

128

The Destruction Effects of Semiconductors by High Power Electromagnetic Wave

Full Text Available

1998-04-01

129

Synthesis and antimicrobial effects of colloidal silver nanoparticles in chitosan by?-irradiation

Full Text Available

2007-09-01

130

Superconductors for Power Transmission and Distribution

Not Available

2010-04-01

131

ScienceCinema

...the effects of global warming ...

132

Studies on the Effect of Spices and Flavoring on Ascorbic Acid content

Some effects of the plasma nitriding process on layer properties

Full Text Available

1974-03-01

133

Search for Medicinal Plants on Improvable Effect of Intestinal Microflora

Not Available

1992-09-01

134

Screening of Multifunctional Bacteria with Biocontrol and Biofertilizing Effects

Full Text Available

2007-02-01

135

Remifentanil-induced pronociceptive effect and its prevention with pregabalin.

Full Text Available

2011-08-01

136

Remark on the effect of varying density of states in superconducting A-15 compounds

Full Text Available

2011-03-01

137

Recoil Effects of Neutron-Irradiated Metal Permanganates

Not Available

1982-03-01

138

Monitoring station for medical effects of exposure during radiation accidents

Full Text Available

1988-06-01

139

Evaluation of Subway Induced Vibration Effects on Building Structures

Short communication.

1995-04-06

140

Effects of Preemptive Gabapentin on Postoperative Pain after Mastectomy

Full Text Available

2008-10-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

141

Effects of Opuntia ficus-indica on Lipidperoxide and cholesterol level

Full Text Available

2004-10-01

142

Effects of Licorice on Embryonic and Fetal Development in Rats

Full Text Available

2003-12-01

143

Effects of Antioxidant and Flavor Compionents of Zingiber mioga Rosc

Full Text Available

2005-12-01

144

Effectiveness of Selective Peripheral Denervation for the Treatment of Spasmodic Torticollis

Full Text Available

2007-06-01

145

Effect of processing route on the composition and properties of hemp fibre

Full Text Available

2005-11-01

146

Effect of chelate rigidity on in vivo radioimmunoconjugate distribution

Full Text Available

147

Effect of Spices on the Growth of Pathogenic Bacteria

Short note.

1991-01-01

148

Effect of Spices on hepatic microsomal enzyme function in mice

Full Text Available

1997-08-01

149

Effect of Garlic on the Digestion of Beef Protein during Storage

Full Text Available

1984-06-01

150

Effect of Electromagnetic Fields on Growth of Human Cell Lines

Full Text Available

1991-10-01

151

Distribution of Photovoltaic Energy Including Topography Effect

Full Text Available

2001-10-01

152

Development of a Cost Effective Radio Communication System for UAS

Full Text Available

2011-04-01

153

Clinical effectiveness of antidepressants and antipsychotics in chronic benign pain.

Full Text Available

2008-06-01

154

Antioxidative Effects of Chitosan Meat Sausage

PMID:1354044

1992-01-01

155

Antioxidative Effect of Ethanol Extract for 5 Kinds of Spice

Full Text Available

2001-06-01

156

An Effective Grid Resource Management Model Based on Cloud Computing Platform

Full Text Available

2004-11-01

157

An Aplication Effect of UV-Absorbent on The Indigo Dyed Products

Not Available

2011-02-01

158

14 MeV neutron irradiation effects on window materials

Full Text Available

1999-08-01

159

The effects of organosulfur compounds upon the storage stability of Jet A fuel

No abstract prepared

1998-01-01

160

The Effects of Flame Retardant Combinations in PVC ...

This study examined the effect of sulfur-containing compounds on the storage stability of Jet A

1981-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

The Effect of the Temperature to Which the Material is Heated ...

... Title : The Effects of Flame Retardant Combinations in PVC-Epoxidised Natural Rubber Miscible Blends: Antimony Trioxide in Combination with ...

1989-03-01

162

Heavy Metals Effect on Animal Cells

... The Effect of the Temperature to Which the Material is Heated on the Process of Formation of Intermetallic Compounds in Magnetic Pulse Welding,. ...

1980-09-01

163

Effects of Pentobarbital Anesthesia on Survival, 'Escherichia ...

Studies of the Superheavy-metal Effect as a Stress-factor on Protein Biosynthesis and Cytoskeleton Integrity in Animal Cells

164

Effect of dietary constituents on the absorption of lead in the human

... Title : Effects of Pentobarbital Anesthesia on Survival, 'Escherichia coli' Clearance, Glucose and Leukocyte Concentration in Dogs Subjected to ...

1978-08-28

165

Effect of Yttrium on the Microstructure of Titanium Alloys,

... biological effects body burden diet intestinal absorption lead lead 203 man

1983-03-01

166

EFFECTS OF SHIELDING ON PROPERTIES OF EDDY ...

... Title : Effect of Yttrium on the Microstructure of Titanium Alloys,. ... The yttrium was added in the melting stage as an oxide or in the elemental form. ...

167

Diaphragm Rupture Effects on an Expanding Flow in a Tube.

... Accession Number : ADD323869. Title : EFFECTS OF SHIELDING ON PROPERTIES OF EDDY CURRENT PROBES WITH FERRITE CUP CORES. ...

1986-08-01

168

Coherency Effects on Retinal Neural Processes (ERG) of ...

... The fundamental problem of diaphragm rupture was studied experimentally to determine the effects on an expanding flow in an evacuated tube. ...

1972-08-01

169

Learning Effect and Standardization Effect in NPP's Construction

... Accession Number : ADA111683. Title : Coherency Effects on Retinal Neural Processes (ERG) of Pseudemys. Descriptive ...

1981-12-01

170

Effective medium theory of the one-dimensional resonance phononic crystal

This paper describes the learning effect and standardization effect in the nuclear power construction, analyses their influence degree on nuclear power economics. Furthermore, the paper provides the ideas on how to improve the economics of nuclear power through implementing the learning effect and standardization effect. The paper also concludes that the learning rate in China is better than the average value in the world by analysis actual example. (authors)

2009-09-01

171

Physical mechanism in the free-electron laser

A general theoretical scheme to describe the effective modulus and mass density for acoustic metamaterials is presented. For such a purpose, an effective medium theory of a one-dimensional acoustic waveguide containing subwavelength-sized Helmholtz resonators is formulated. It is shown that, when the wavelength is much larger than the periodic length and the size of the resonators, the whole composite structure can be treated as an effective homogeneous medium in accounting for its acoustic properties. It is also shown that the acoustic characteristics, such as the effective modulus and the effective mass density, can be determined precisely from the transmission and the reflection data. The calculated effective modulus and effective mass density confirm that this structure behaves as a homogeneous metamaterial with a negative ...

2008-02-06

172

Ionising radiation. Part 2

In this paper some physical mechanisms are described, which determine some new free-electron laser configurations. These mechanisms comprise some physical effects of the radiant emission of an electron beam at the interaction with the medium it is crossing. They are based on the Cherenkov effect, Smith-Purcell effect, optical klystron, Rumakhov effect and limited interaction effect. (Author).

1992-09-21

173

Effects of gamma irradiation on physiological effectiveness of Korean medicinal herbs

A brief tutorial on the health effects of ionising radiation is presented. The distinction between somatic and genetic health effects is explained. The two types of somatic health effects, i.e., acute and chronic effects, are discussed, as well as the concepts of ''deterministic'' and ''stochastic'' (also called ''probabilistic'') health effects. The possibility of cancer caused by DNA damage is discussed. The document ends with the definition of some key radiation terms.

2000-11-01

174

The effects of exercise and stress on the survival and maturation of adult-generated granule cells

Effects of gamma irradiation on the physiological effectiveness of Korean medicinal herbs were investigated. The physiological effectiveness including antioxidant and anticomplement function, nitrite scavenging and electron donating ability of Korean medicinal herbs by gamma irradiation at 10 kGy did not differ from that of the nonirradiated control.

1999-03-01

175

TJ-41 Induces Apoptosis and Potentiates the Apoptotic Effects of 5-FU in Breast Cancer Cell Lines

Stress strongly inhibits proliferation of granule cell precursors in the dentate gyrus, while voluntary running has the opposite effect. Few studies, however, have examined the possible effects...Full Text Available

2009-10-01

176

Mouse model predicts effects of smoking and varenicline on event-related potentials in humans

Recent studies suggest that TJ-41, a herbal drug, possesses chemotherapeutic effects. Accordingly, this study was undertaken to investigate the anticarcinogenic effects of TJ-41 on human breast cancer...Full Text Available

2009-01-01

177

Memory effect in air in the presence of vacuum breakdown mechanism

Background:Nicotine alters auditory event-related potentials (ERPs) in rodents and humans and is an effective treatment for smoking cessation. Less is known about the effects of...Full Text Available

2010-06-01

178

Health effects of urea formaldehyde foam insulation: evidence of causation.

Investigation of memory effects in air at 0.7 mbar pressure in the presence of vacuum electrical breakdown mechanism has been performed in this paper. The memory effect has been followed using the time delay method.

2008-07-01

179

Epidemiological survey of the effects of low level radiation dose: a comparative assessment

Studies of health effects of urea formaldehyde foam insulation (UFFI) were critically reviewed by means of accepted rules for evidence of causation. Three categories of health effects were examined:...Full Text Available

1986-04-01

180

Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials

This volume presents the collations tables of a six volume comparative epidemiological survey of the effects of low level radiation dose. Data are collated for the effects observed in the following irradiated groups:- Preconception irradiation, intra-uterine irradiation, childhood irradiation, adult irradiation. (UK).

1993-10-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

181

Cost-Effectiveness of an Opportunistic Screening Programme and Brief Intervention for Excessive Alcohol Use in Primary Care

Objectives To assess the effectiveness of calcium supplementation for improving bone mineral density in healthy children and to determine if any effect is modified by other factors and...Full Text Available

2006-10-14

182

Cost-Effectiveness Analysis of Proposed Effluent Limitations Guidelines and Standards for the Metal Products and Machinery Industry (Phase 1).

BackgroundEffective prevention of excessive alcohol use has the potential to reduce the public burden of disease considerably. We investigated the cost-effectiveness of Screening...Full Text Available

183

Beneficial Effect of a Short-Acting NO Donor for the Prevention of Neointimal Hyperplasia

This cost-effectiveness analysis supports the proposed effluent limitations guidelines and standards for the Metal Products and Machinery Industry (MP and M) Phase I Industry. The report assesses the cost-effectiveness of five regulatory options for indir...

1995-01-01

184

Assessing the effectiveness and cost effectiveness of adaptive e-Learning to improve dietary behaviour: protocol for a systematic review

Nitric oxide (NO)-based therapies effectively inhibit neointimal hyperplasia in animal models of arterial injury and bypass grafting, but are not available clinically. We created a simple, effective,...Full Text Available

2008-01-01

185

Adding effect sizes to a systematic review on interventions for promoting physical activity among European teenagers

BackgroundThe composition of habitual diets is associated with adverse or protective effects on aspects of health. Consequently, UK public health policy strongly advocates dietary...Full Text Available

186

New concepts in risk assessment for patients with radiological treatment

This commentary adds effect sizes to the recently published systematic review by De Meester and colleagues and provides a more detailed insight into the effectiveness of interventions to promote physical...Full Text Available

187

CT colonography and cost-effectiveness

In radiation risk assessment it must be differentiated between somatic and genetic effect on the one hand as well as between stochastic and non-stochastic effect on the other. According to definitions of the ICRP report 26 the limit for the dose equivalent of all tissues prevents non-stochastic radiation effects. With stochastic radiation effects probably exist no threshold doses; therefore the ALARA principle must be applied concerning radiation protection. The individual risk by stochastic radiation effects in its linear, linear-quadratic and quadratic extrapolations, respectively, is discussed in detail. The effective stochastic dose equivalent (H/sub eff/) as well as collective dose and collective damage are outlined.

1986-01-01

188

VIGILANCE, PREDATION RISK, AND THE ALLEE EFFECT IN DESERT BIGHORN SHEEP

CT colonography (CTC) is increasingly advocated as an effective initial screening tool for colorectal cancer. Nowadays, policy-makers are increasingly interested in cost-effectiveness issues. A number of studies assessing the cost-effectiveness of CTC have been published to date. The majority of findings indicate that CTC is probably not cost-effective when colonoscopy is available, but this conclusion is sensitive to a number of key parameters. This review discusses the findings of these studies, and considers those factors which most influence final conclusions, notably intervention costs, compliance rates, effectiveness of colonoscopy, and the assumed prevalence and natural history of diminutive advanced polyps. (orig.)

2008-11-15

189

Toxicological properties of lead.

... 2004)068[0519:VPRATA]2.0.CO;2 VIGILANCE, PREDATION RISK, AND THE ALLEE EFFECT IN DESERT ... revealed that predation risk (as es...

190

Technology Improvement Pathways to Cost-Effective Vehicle Electrification: Preprint

The pathological effects of lead on the renal, nervous, reproductive, endocrine, and immune systems have been reviewed. Emphasis is placed on reported subclinical effects due to chronic, low-level lead...Full Text Available

1977-08-01

191

THE BALDWIN EFFECT AND GENETIC ASSIMILATION: REVISITING TWO MECHANISMS OF EVOLUTIONARY CHANGE MEDIATED BY PHENOTYPIC ...

This paper evaluates several approaches aimed at making plug-in electric vehicles (EV) and plug-in hybrid electric vehicles (PHEVs) cost-effective.

2010-02-01

192

Strong-interaction effect measurements in sigma hyperonic atoms of W and Pb

... 1111/j.1558-5646.2007.00203.x THE BALDWIN EFFECT AND GENETIC ASSIMILATION: REVISITING TWO MECHANISMS OF ... to phenotypic plast...

193

Size Effects in Impact Damage of Composite Sandwich Panels Alan ...

Strong-interaction effects have been observed in the x-ray spectra of atoms formed with [Sigma][sup [minus

1993-03-01

194

Saturation effects at LHC energies

Wade. Jackson. - Army. VTD at NASA. Langley. ABSTRACT. Panel size has a large effect on the impact response and resultant damage level of honeycomb sandwich ...

195

Possible health effects of working with VDUs.

Within the framework of a modified Balitsky-Kovchegov equation, we calculated and provide estimates of non-linear saturation effects expected in the LHC range of energies.

2005-01-01

196

Mechanism of viscosity effect on magnetic island rotation

A summary of the effects presented here is given in the table. The designation "factor present" implies that there is knowledge (from human or animal studies, or both) of a specific factor(s) present...Full Text Available

1989-04-01

197

Influence of nebivolol on anticonvulsant effect of lamotrigine

It is shown that plasma viscosity does not influence the magnetic island rotation directly. Nevertheless, it leads to nonstationarity of the plasma velocity. This nonstationarity is the reason of the viscosity effect on island rotation. (author)

2000-04-01

198

Objective:The present study describes the effect of nebivolol (NBV) either alone or in combination with lamotrigine (LTG) using increasing current electroshock seizures...Full Text Available

2009-02-01

199

Human factors

Flame Retardant Effects in PVC-Epoxidised Natural Rubber ...

This is a presentation on Human Factors in reactor operations. It discusses issues that deal with power plant operations, training and design, operational effectiveness and safety, supporting people to achieve effective and error free performance.

2002-07-01

200

Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects, and ...

... Title : Flame Retardant Effects in PVC-Epoxidised Natural Rubber Miscible Blends: Halogen and Non-Halogen Based Additives,. Corporate Author : ...

1989-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

201

Efficacy and adverse effects of intravenous lignocaine therapy in fibromyalgia syndrome

... Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects, and Genomic InstabilityMary Helen Barcellos-Hoff1a ... ...

202

Effects of phenoxybenzamine on bladder neck opening1

BackgroundTo investigate the effects of intravenous lignocaine infusions (IV lignocaine) in fibromyalgia.MethodsProspective study...Full Text Available

203

Effects of Yttrium Microalloying on the Epitaxial Grain Growth ...

A study of the effects of the action of phenoxybenzamine on bladder neck opening during micturition is reported. Twenty patients with symptoms of prostatism but minimal prostatic enlargement were studied....Full Text Available

1980-05-01

204

Effect of ginger on gastric motility and symptoms of functional dyspepsia

... Accession Number : ADA137272. Title : Effects of Yttrium Microalloying on the Epitaxial Grain Growth in Ti-6Al-4V Weld Fusion Zones. ...

1983-10-01

205

Effect of gamma radiation and bag packaging materials on the development of Dermestes maculatus De Geer (Coleoptera: Dermestidae) in sword fish

AIM: To evaluate the effects of ginger on gastric motility and emptying, abdominal symptoms, and hormones that influence motility in dyspepsia.METHODS: Eleven patients with functional dyspepsia...Full Text Available

2011-01-07

206

Effect of Roller Profile on Cylindrical Roller Bearing ... - GLTRS - NASA

... EFFECT OF GAMMA RADIATION AND BAG PACKAGING MATERIALS ON

1998-06-01

207

Effect of Registration on Cyclical Kinematic Data

J.V. Poplawski and Associates, Bethlehem, Pennsylvania. Effect of Roller Profile on Cylindrical. Roller Bearing Life Prediction. NASA/TM2000-210368 ...

208

Effect of Deforestation on a Southwest Ghana Dung Beetle Assemblage (Coleoptera: Scarabaeidae) at the Periphery of ...

Given growing interest in Functional Data Analysis (FDA) as a useful method for analyzing human movement data, it is critical to understand the effects of standard FDA procedures, including...Full Text Available

2010-08-26

209

Diagnostics of Radionuclides Effects Results

... 1081:EODOAS]2.0.CO;2 Effect of Deforestation on a Southwest Ghana Dung Beetle Assemblage (Coleoptera: ... The survey provided a...

210

Cooperative Effects on Transient Spectral Hole Burning

Development of New Methods and Means of Assessing of Consequences of Radionuclide and Heavy Metal Salt Effect, Criteria of Forecasting Physiological State and Productivity of the Farm Animals under Conditions of Ecological Pollution of Environment

211

Cooperative Charging Effects of Fibers From Electrospinning ...

... of Dist SpeA tI/ __LLL5' Page 5. 3 the coherent effects on the spontaneous radiation, we calculate the pump- field-induced ...

1992-06-01

212

Contamination Effects of Satellite Material Outgassing ...

... In the Proceedings of INTC 2003, we studied charging effects on target coverage during electrospinning (16). ... of Fibers from Electrospinning of ...

2005-01-05

213

Camouflage Patterns-Effects of Size and Color.

... A detailed analysis of QCM errors is ... Surface Effects of Satellite Outgassing Products." AIAA Journal ... 9. Rauschenbach, H. S. Solar Cell Array Design ...

1990-12-01

214

Biological radiation effects

... CAMOUFLAGE PATTERS- EFFECTS OFSIZE AND COL0R.-(U I'. * ... Camouflage, survei.Ilance, countersurveiliance, vi~sion, color ...

1979-07-01

215

Atmospheric Scintillation Effects on Electromagnetic Weapons

The stages of processes leading to radiation damage are studied, as well as, the direct and indirect mechanics of its production. The radiation effects on nucleic acid and protein macro moleculas are treated. The physical and chemical factors that modify radiosensibility are analysed, in particular the oxygen effects, the sensibilization by analogues of nitrogen bases, post-effects, chemical protection and inherent cell factors. Consideration is given to restoration processes by excision of injured fragments, the bloching of the excision restoration processes, the restoration of lesions caused by ionizing radiations and to the restoration by genetic recombination. Referring to somatic effects of radiation, the early ones and the acute syndrome of radiation are discussed. The difference of radiosensibility observed in mammalian cells and main observable alterations in tissues and organs are commented. ...

1976-01-01

216

An Intrinsic Baldwin Effect in the H Beta Broad Emission Line in the Spectrum of NGC 5548

... 4. TITLE AND SUBTITLE Atmospheric Scintillation Effects on Electromagnetic Weapons 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. ...

2008-12-01

217

A framework for evolutionary systems biology

We investigate the possibility of an intrinsic Baldwin effect (i.e., nonlinear emission-line

2003-01-01

218

http://jr.chemwatch.net/ausmud/msds.exe?mode=SAP&cwno=4902-93&c

BackgroundMany difficult problems in evolutionary genomics are related to mutations that have weak effects on fitness, as the consequences of mutations with large effects are often...Full Text Available

219

Wastenet

CHRONIC HEALTH EFFECTS

220

[The effect of ascorbic acid on a new urine test strip for the detection of erythrocytes].

[Effects of anaerobic and aerobic exercises in athletes on the variation of the parameters of oxygen transport systems during different seasons of the year].

PMID:7177024

1982-11-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

221

Water-Soluble Prodrug of Anti-Microtubule Agent Plinabulin: Effective Strategy with Click Chemistry.

PMID:18472586

222

Therapeutic effects of topical application of ozone on acute cutaneous wound healing.

PMID:21956869

2011-09-29

223

Therapeutic Effects of Bergenin and Acetylbergenin on Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Full Text Available

2009-06-01

224

The intrinsic nature of the Baldwin effect

Full Text Available

2000-12-01

225

The effect of Allium sativum L. extract on hepatic function in rats with $CCl_4$-induced (hepatic) injury

The relationship between the fluxes of the two strongest UV emission lines and flux in the continuum

1992-01-01

226

The anti-inflammatory effects of ulinastatin in trauma patients with hemorrhagic shock.

Full Text Available

2010-05-01

227

The Essentials of Mathematics, Grades 7-12 Effective Curriculum, Instruction, and Assessment

Full Text Available

2010-01-01

228

The Enzymatic Regulatory Effects of Laninaria japonica Fucoidan Extract in Hepatotoxicity

The Essentials of Mathematics, Grades 7-12

2006-01-01

229

The Effects of Integrated Environmental Experience Program on Environmental Attitude of Elementary Schoolers

Full Text Available

2006-12-01

230

The Effects of Additions of In & Sb on Resistivity & Sensitivity in Tin Oxide Gas Sensors

Full Text Available

2010-12-01

231

The Effect of Self-esteem, Academic Achievement and Family Functioning of Adolescents on Hope

Full Text Available

1992-11-01

232

The Effect of Radiated Electromagnetic Wave by Digital Modulation Signals on the Electronic Devices

Full Text Available

2001-01-01

233

The Effect of Garlic and Medicinal Plants Extracts on the Liver Function and Lipid Metabolism of Rats Administered with Alcohol

Full Text Available

2011-02-01

234

The Effect of Additional Mobilization with Conservative Physical Therapy in Patients with Frozen Shoulder on ROM and Subjective Pain Scale

Full Text Available

2009-05-01

235

The Damage of Microcontroller Devices due to Coupling Effects under High Power Electromagnetic Wave by Magnetron

Full Text Available

2009-11-01

236

The Acute Effect of Trimetazidine on the High Frequency Fatigue in the Isolated Rat Diaphragm Muscle

Full Text Available

2008-12-01

237

Temperature and vital effect controls on Bamboo coral (Isididae) isotopegeochemistry: A test of the "lines method"

Full Text Available

2004-06-01

238

THE EFFECTS OF ONE MEGACYCLE ULTRASONIC ...

Abstract not provided

2011-03-01

239

THE EFFECT OF FIBRE MISALIGNMENT ON THE ...

... ULTRASONIC VIBRATION TO PORTLAND CEMENT-WATER PASTE REDUCES THE ULTIMATE COMPRESSIVE STRENGTH OF MORTARS ...

1959-09-09

240

Symposium (International) (4th) on DETONATION Held at ...

... and testing of unidirectional composites, there are serious doubts about the possibility of obtaining a true ultimate compressive strength for this kind ...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

241

Surface radiation effects on natural convection cooling of discrete heat source in an open-top cavity

... 442 RHF Stresau CONFINEMENT EFFECTS IN EXPLODING BRIDGEWIRE INITIATION OF DETONATION ..... ...

1965-10-15

242

Statistical cut-off criterion

Short communication.

1995-08-14

243

Some comments on BEIR III

... radiation effects human populations low dose irradiation neoplasms radiation

1980-01-01

244

SAXS studies of the injection molding effects on the nanostructure of polyesters. I. Polybutylene terephthalate (Pbt)

... organizations irradiation radiation doses radiation effects RADIATIONS.

1982-01-01

245

Regrinding Effect of Flat End-Mill Tool for Recycling of Tungsten Carbide (WC-Co) Material

No abstract prepared.

2004-07-01

246

Reaction-diffusion effects on species mixing rates in turbulent premixed methane-air combustion

Full Text Available

2008-12-01

247

Radioprotective effect of fish products

No abstract prepared.

2009-06-01

248

Radiological equipment for emergencies

New fish cans were prepared in the Institute of Fish Industry, Burgas (BG), containing pectin and additives. A biological experimental study was conducted to investigate the decontaminating effect of the new products. The results demonstrated no decontaminating effect in relation to radiocesium and radiostrontium. A pronounced prophylactic effect was observed in case of external irradiation, judged by endogenous spleen colonies. (author).

1993-12-02

249

Radiative Heat Transfer Augmentation in Gas-Fired Radiant Tube Burners by Porous Inserts: Effect of Insert Geometry

A brief guide to training and equipment needed to effectively manage victims of radiation accidents. (DT)

1985-01-01

250

Radiation technology of wood-plastic composite materials

Not Available

1993-07-01

251

Radiation effects on the shoot tip culture of chrysanthemum

... radiation effects RADIATIONS. WOOD-PLASTIC COMPOSITES.

1981-10-02

252

RESEARCH PAPERS : AN EFFECT OF THE REDUCTION OF TOXICITY USING BICARBONATE CATALYST ON WASTEWATER

Japanese (Mar 1974). Japan Mabuchi, Toshio Kuwada, Hikaru . Kagawa Univ.,

253

Protective effects of Opuntia ficus-indica on Glutathione and Antioxidative Enzyme

Full Text Available

2004-06-01

254

Protective and therapeutic effects of swimming exercise training on diabetic peripheral neuropathy of streptozotocin-induced diabetic rats.

Full Text Available

2003-12-01

255

Protective Effects of Acetylbergenin against Carbon Tetrachloride Induced Hepatotoxicity in Rats

PMID:19169052

2008-11-01

256

Protective Effect of Some Medicinal Plants on tert-Butyl Hydroperoxide-Induced Oxidative Stress in Human Keratinocytes

Full Text Available

2001-04-01

257

Prevention of Alloxan-induced Diabetes by Se-Methylselenocysteine Pretreatment in Rats: The Effect on Antioxidant System in Pancreas

Full Text Available

2008-12-01

258

Potentiation of Antitumor Effect of Radiotherapy by Recombinant Tumor Necrosis Factor-$\\alpha$

Full Text Available

2009-06-01

259

Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures.

Full Text Available

1998-09-01

260

Peristaltic flow of a couple stress fluid under the effect of induced magnetic field in an asymmetric channel

PMID:17276750

2007-02-15

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

261

POTENTIATION BY PENTOBARBITAL OF THE PROTECTIVE ...

Not Available

2011-01-01

262

PRODUCT NAME BARITE

Wastenet

the low levels of crystalline silica in this product, chronic health effects are not anticipated with normal

263

On the effects of boron and phosphorus primary impurities in p-type silicon material for solar cells

... Accession Number : AD0268549. Title : POTENTIATION BY PENTOBARBITAL OF THE PROTECTIVE EFFECT OF AET AGAINST GAMMA RAYS. ...

1961-10-01

264

On the Relationship between Typhoon Intensity and Formation Region: Effect of Developing and Decaying ENSO

Not Available

1979-01-01

265

New physics effects on Higgs production at #gamma##gamma# colliders

Full Text Available

2008-02-01

266

Magnetic field effect on fluid flow characteristics in a pipe for laminar flow

We study heavy physics effects on the Higgs production in #gamma##gamma# fusion using the effective Lagrangian approach. We find that the effects coming from new physics may enhance the standard model predictions for the number of events expected in the final states b-barb, WW, and ZZ up to one order of magnitude, whereas the corresponding number of events for the final state t-bart may be enhanced up to two orders of magnitude.

1996-02-20

267

Linear Analysis of the In-Phase and Out-of-Phase Stability Behavior of a Natural Circulation Reactor: Upscaling Effects

Full Text Available

2011-02-01

268

Influences of B Number Effect on the Burning Rate of Solid Fuel in Single Port Hybrid Rocket

Not Available

2007-02-01

269

Inertial Dynamic Effect on the Rates of Diffusion-Controlled Ligand-Receptor Reactions

Full Text Available

2008-03-01

270

Individual or combined effects of enalapril and verapamil on chronic cyclosporine nephrotoxicity in rats.

Full Text Available

2011-08-01

271

In-vivo study on the harmful effect of the extremely low frequency unipolar pulsating magnetic field in mice.

Full Text Available

1999-12-01

272

Implantation-plasma treatment of martensitic steel and titanium alloy

Full Text Available

1997-04-01

273

Impairing Effects of Acute Glucose Overload on Calcium Homeostasis in Vascular Endothelial Cells

One of the effective methods of deep modification of the surface of steels and alloys is the combination of ion implantation and plasma nitriding. In this work, the long-range effect is demonstrated in the case of combination of the effect of high- and low-energy ions of nitrogen on a martensitic steel for each ion implantation is usually not effective, and a titanium alloy used widely in industry.

2001-07-01

274

Ignition and Flame Propagation of Solid Fuel with Radiation Effect in a Cylindrical Combustor

Full Text Available

1998-12-01

275

Flood Routing Analysis Considering the Effects of Dams in Han River

Full Text Available

2001-02-01

276

Ferromagnetism in Mn-doped GaAs layers: Effects of laser annealing

Full Text Available

2005-09-01

277

Epoxidised natural rubber/silica hybrid nanocomposites by sol-gel technique: Effect of reactants on the structure and the properties

The properties of Mn-doped GaAs layers grown by laser deposition were investigated with measurements of Hall effect and magneto-optical Kerr effect (MOKE). The electrical and magnetic parameters of the layers were defined by growth temperature and quantity of sputtered Mn. It was shown that room-temperature ferromagnetism is revealed by MOKE and, after ruby laser 25 ns pulse annealing, by Hall effect measurements.

2006-05-15

278

Environmental Effects on Oil Pipelines

Not Available

2005-01-01

279

Enhancement of Whitening Effects of Lithospermum erythrorhizon Extracts by Ultra High Pressure

Determination of the Ecology Factor for the Magistral Oil Pipelines, Working in Difficult Hilly and Geology Conditions

280

Enhancement of Antioxidant Activities and Whitening Effect of Acer mono Sap Through Nano Encapsulation Processes

Full Text Available

2011-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

281

Effects of thyroxine on hyperkalemia and renal cortical Na+, K+ - ATPase activity induced by cyclosporin A.

Full Text Available

2011-06-01

282

Effects of the Feeding Mixture of Mushrooms and Vegetables Oils on the Lipid Component and Fatty Acid Composition of Liver in Rats

Full Text Available

2002-10-01

283

Effects of the Excitation Level on the Dynamic Characteristics of Electrical Cabinets of Nuclear Power Plants

Full Text Available

1994-10-01

284

Effects of season and body condition score on lipid metabolism and oxidative status of periparturient dairy cows

Full Text Available

2010-06-01

285

Effects of positive and negative stretching on the structure and properties of polyacrylonitrile fibers in the pre-oxidation process

No abstract prepared.

2005-07-01

286

Effects of extracts of medicinal plants in the parasitaemia of Trypanosoma cruzi and in the biodistribution of the technetium-{sup 99m}

Full Text Available

2011-06-01

287

Effects of Treatment According to Tattoo Color, Site and Duration with the Q-Switched Alexandrite Laser

No abstract prepared.

2008-10-15

288

Effects of Traditional Salt on the Quality Characteristics and Growth of Microorganisms from Kimchi

Full Text Available

289

Effects of Single or Mixed Supplements of Plant Extract, Fermented Medicinal Plants and Lactobacillus on Growth Performance in Broilers

Full Text Available

2010-02-01

290

Effects of Simulated Acid Rain on Growth, Pigments and Leaf Surface Morphology of the Seedlings of Amaranthus tricolor L.

Full Text Available

2007-09-01

291

Effects of Restricted Feeding during Growing Period on Laying Performance and Egg Quality in Layers

Full Text Available

1994-08-01

292

Effects of Polymerization and Spinning Conditions on Mechanical Properties of PAN Precursor Fibers

Full Text Available

2008-03-01

293

Effects of Oxygen Enrichment on the Structure of Premixed Methane/Fluorinated Compound Flames

Full Text Available

2010-09-01

294

Effects of Nitric Oxide Donor Supplementation on Copper Deficient Embryos and Nitric Oxide-Mediated Downstream Signaling

Full Text Available

2011-08-01

295

Effects of Medicinal Plants on the Quality and Physiological Functionalities of Traditional Ginseng Wine

Full Text Available

2008-12-01

296

Effects of MeV ion irradiation on crystallization of amorphous Ge films

Full Text Available

2007-06-01

297

Effects of Liming on Uptake to Crops of Heavy Metals in Soils amended with Industrial Sewage Sludge

Short communication.

1995-12-31

298

Effects of Horseback Riding Simulation Machine Training on Gross Motor Function for the Children with Cerebral Palsy

Full Text Available

2002-03-01

299

Effects of Gas Flow Ratio on the Properties of Tool Steel Treated by a Direct Current Flasma Nitriding Process

Full Text Available

2010-05-01

300

Effects of Fish Oil and Some Seed Oils on Lipid Composition of Serum in Rats

Full Text Available

2005-10-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

Effects of Fish Oil and Some Seed Oils on Fatty Acid Compositions of Liver and Brain Tissue in Rats

Full Text Available

1991-08-01

302

Effects of Exposure Period on the Developmental Toxicity of 2-Bromopropane in Sprague-Dawley Rats

Full Text Available

1991-10-01

303

Effects of Elevated Atmospheric $CO_2$ Concentrations on Soil Microorganisms

Full Text Available

2008-12-01

304

Effects of Electric Current Stimuli and High-Voltage Electric Field Treatments on Brown Rice Germination

Full Text Available

2004-12-01

305

Effects of Dissolved Oxygen on Fungal Morphology and Process Rheology During Fed-Batch Processing of Ganoderma lucidum

Full Text Available

2010-04-01

306

Effects of Different Dietary Oils on Hepatic Mitochnodial Lipid Composition and Adenine Nucleotide Translocase Activity in Rat

Full Text Available

2010-04-01

307

Effects of Dietary Korean Mistletoe on Performance and Blood Characteristics in Broilers

Full Text Available

1993-07-01

308

Effects of Dietary ?-Fatty Acids on the Fatty Acid Composition of Pork and Plasma Lipids in Swine

Full Text Available

2007-06-01

309

Effects of Dehydration Methods and Storage Conditions on Germinability of Pelleted Carrot Seeds

Full Text Available

2007-05-01

310

Effects of Coulomb and kaon nuclear potentials on soft K{sup +} production from nuclei

Full Text Available

2009-04-01

311

Effects of Concrete and Wood Building Environments on Pregnant Dams and Embryo-Fetal Development in Rats

No abstract prepared.

2002-03-01

312

Effects of Callophyllis japonica powder on carbon tetrachloride-induced liver injury in rats

Full Text Available

2009-12-01

313

Effects of Calcium Supplementations on Mineral Metabolism during Pregnancy with Calcium-Deficient Young Adult Rats

Full Text Available

2005-09-01

314

Effects of Ca Supplementation on Mineral Metabolism during Pregnancy and Lactation of Calcium-Deficient Young Adult Rats

Full Text Available

2003-06-01

315

Effective dose equivalent in nuclear medicine investigations

Full Text Available

2004-07-01

316

Effect on the Quality Characteristics of Korean Traditional Wines with the Addition of Rosemary (Rosmarinus officinalis L.)

... radiation hazards hazards health hazards MEDICINE. SOMATICALLY

1984-05-07

317

Effect of the medicinal plant Echinacea purpurea on the bioavailability of the radiopharmaceutical {sup 99M}TC-sodium pertechnetate

Full Text Available

2006-12-01

318

Effect of the Toluene Administration on the Liver Damage in Rats Fed Low or Standard Protein Diet

No abstract prepared.

2008-10-15

319

Effect of the Mixing Extraction of Perilla Seed and Peanut on Physicochemical Characteristics and Oxidative Stability of Perilla Oil

Full Text Available

1996-12-01

320

Effect of simulated Acid Rain on the Morphology and Enzyme of Perilla frutescens var. japonica Hara

Full Text Available

1999-12-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

Effect of outside air ventilation rate on volatile organic compound concentrations in a call center

Full Text Available

1996-04-01

322

Effect of nitric oxide on endoplasmic reticulum calcium homeostasis, protein synthesis and energy metabolism

No abstract prepared.

2003-04-01

323

DEFF Research Database (Denmark)

ATPase, endoplasmic reticulum, calcium, ischaemia

2000-01-01

324

Effect of equal channel angular pressing on the deformation behaviour of magnesium alloy AZ31 under uniaxial compression

Effect of Zinc-Enriched Yeast Supplementation on Serum Zinc and Testosterone Concentrations in Ethanol Feeding Rats

No abstract prepared.

2006-07-01

325

Effect of Weight and Apllied Force on the Friction Coefficient of the Spunlace Nonwoven Fabrics

Full Text Available

2008-07-01

326

Effect of TIBA, PCIB and phloroglucinol on somatic embryo maturation and germination in Japanese larch (Larix leptolepis)

Full Text Available

2010-04-01

327

Effect of Supplementation with Docosahexaenoic Acid from Gestation to Adulthood on Spatial Learning Performance in Rat

Full Text Available

2009-09-01

328

Effect of Ondansetron Alone and Combination of Naltrexone and Ondansetron on Alcohol Intake in C57BL/6 Mice

Full Text Available

2007-10-01

329

Effect of Nitrite and Nitrate as the Source of OH Radical in the O3/UV Process with or without Benzene

Full Text Available

2007-11-01

330

Effect of Milling Medium Materials on Mechanical Alloying of Mo-65.8at%Si Powder Mixture

Full Text Available

2011-08-01

331

Effect of Low Night Temperature on Reproductive Organ Development in Relation to Pollen Viability of Bell Pepper

Full Text Available

1997-09-01

332

Effect of Lotus (Nelumbo nucifera) Leaf Powder on the Quality Characteristics of Chicken Patties in Refrigerated Storage

Full Text Available

2009-05-01

333

Effect of KI on improving copper corrosion inhibition efficiency of benzotriazole in sulfuric acid electrolytes

Full Text Available

2011-02-01

334

Effect of Inorganic Fillers on the Properties of Hydrated PAN Melt(I) -Rheological Properties of Hydrated PAN Melt-

A synergistic effect exists when benzotriazole (BTAH) and iodide ions are used together to prevent the corrosion of copper in sulfuric acid. The nature of this effect has been studied systematically by using electrochemical techniques and X-ray photoelectron spectroscopy. The synergistic effect is due largely to the formation of a film of Cu(IBTA) complex and is probably polymeric in nature. This new complex film greatly depresses copper dissolution.

1993-10-01

335

Effect of High Omega-3 Fish Intake on Lipid Peroxidation

Full Text Available

2000-10-01

336

Effect of Heat Treatment on CO2 Adsorption of Ammonized Graphite Nanofibers

Omega-3 Fatty Acids; Lipid Peroxidation

2011-05-31

337

Effect of Heat Treatment of Garlic Added Diet on the Blood of Spontaneously Hypertension Rat

Full Text Available

2010-03-01

338

Effect of Garlic and Medicinal Plants Composites on Antioxidant Activity and Lipid Levels of Liver in Hypercholesterolemic Rats

Full Text Available

1997-02-01

339

Effect of Extracelluar Matrix on Cell-Surface Interactions and Growth of Cardiomyocyte(HL-1)

Full Text Available

2009-12-01

340

Effect of Ethanol-pretreatment on the Liver Xanthine Oxidase Activity in Xylene-treated Rats

Full Text Available

2010-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

Effect of Dietary Supplementation of Acanthopanax senticosus and Eucommia ulmoides on Antioxidant Defense System in Laying Hens

Full Text Available

1998-08-01

342

Effect of Dietary Protein on the Changes of Lipoprotein Fractions in Carbon Tetrachloride-Treated Rats

Full Text Available

2010-03-01

343

Effect of Dietary Energy, Protein on Growth and Blood Composition of Cross Bred Chicks

Full Text Available

1993-04-01

344

Effect of Dietary Anti-oxidant Supplementation on Telomere Length and Egg Quality in Laying Hens

Full Text Available

2008-09-01

345

Effect of Di-(2-ethylhexyl)-phthalate on Sphingolipid Metabolic Enzymes in Rat Liver

Full Text Available

2008-09-01

346

Effect of Cyclohexanone Treatment on the Activities of Oxygen Free Radical Metabolizing Enzyme in the Liver Damaged Rats

Full Text Available

2011-09-01

347

Effect of Cyclohexane Treatment on the Liver Damage in CCl4-Pretreated Rats

Full Text Available

2002-06-01

348

Effect of Cyclohexane Treatment on Serum Level of Glutathione S-Transferase Activity in Liver Damaged Rats

Full Text Available

2003-06-01

349

Effect of Circadian Rhythms on the Xylene Metabolizing Enzyme Activities in Rats

Full Text Available

2003-06-01

350

Effect of Chitosan Solution on the Inhibition of Pseudomonas fluorescens Causing Bacterial Head Rot of Broccoli

Full Text Available

2001-06-01

351

Effect of Chemical Treatment of Teflon Powder on the Properties of Polyamide 66/Teflon Composites Prepared by Melt Mixing

Full Text Available

2010-06-01

352

Effect of Carbon Source Consumption Rate on Lincomycin Production from Streptomyces lincolnensis

Full Text Available

2011-06-01

353

Effect of COY(Cooking Oil and Yolk Mixture) on Control of Tetranychus urticae

Full Text Available

2004-06-01

354

Effect of Bubbles on Liquid Nitrogen Breakdown in Plane-Plane Electrode Geometry From 100-250 kPa

Full Text Available

2008-09-01

355

Effect of Bisphenol A Administration on Reproductive Toxicant of Dam and Sex Ratio of Pups in Pregnant Mice

Not Available

2011-06-01

356

Effect of Angiotensin-I Converting Enzyme Inhibitory from Hydrolysate of Soybean Protein Isolate

Full Text Available

2005-06-01

357

EFFECT OF SHIP ATTITUDE AND SHIP MOTION ON PRIMARY COOLANT SYSTEM FLOW RATES. Appendix A: DERIVATION OF EFFECT OF ANGULAR ACCELERATION ON DRIVING HEAD IN A NATURAL CIRCULATION REACTOR

Full Text Available

2010-01-01

358

EFFECT OF MICROSTRUCTURE ON THE STRENGTH ...

Analytical techniques for analyzing the effects of ship motion and attitude on the primary coolant system flow rates are presented. Design data for minimizing these effects are given. (C.J.G.)

1960-01-24

359

Conversion gain in a Josephson effect mixer

... THE STRENGTH, TOUGHNESS, AND STRESS-CORROSION CRACKING SUSCEPTIBILITY OF A METASTABLE BETA TITANIUM ALLOY (Ti-11. ...

1970-02-01

360

Contribution to the radiation preparation of wood-plastic materials. Pt. 7

United States Taur, Y. Claassen, JH Richards, PL Department of Physics,

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Contribution to the radiation preparation of wood-plastic materials. Pt. 6

... odd nuclei organic compounds radiation effects radioisotopes synthesis

1974-01-01

362

Contribution to the radiation preparation of wood-plastic materials Pt. 3

... compounds polymers polyolefins polyvinyls radiation effects SYNTHESIS.

1974-01-01

363

Continuous Strategy Development for Effects-Based ...

... compounds plants radiation effects radioisotopes reaction kinetics trees

1974-01-01

364

Climate Change: The Role of Particles and Gases

... BAE Systems Advanced Information Technologies, Inc. APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. ...

2006-02-01

365

ScienceCinema

...global warming ...the effects of global warming ...also the ? that global warming ...

366

Capsaicin induced apoptosis and the enhanced anticancer effect of anticancer drugs in cancer cells

Calculation of some energetic parameters of astatine compounds

Full Text Available

2008-03-01

367

CRC handbook of biological effects of electromagnetic fields

... astatine complexes astatine compounds coulomb energy effective charge

368

Biophotonics and Bone Biology

This book presents the current knowledge about the effects of electromagnetic fields on living matter. The three-part format covers dielectric permittivity and electrical conductivity of biological materials; effects of direct current and low frequency fields; and effects of radio frequency (including microwave) fields. The parts are designed to be consulted independently or in sequence, depending upon the needs of the reader. Useful appendixes on measurement units and safety standards are also included.

1986-01-01

369

Antiproliferation Effects of Germinated-Korean Rough Rice Extract on Human Cancer Cells

One of the more-serious side effects of extended space flight is an accelerated bone loss

2004-01-01

370

Antiproliferation Effects of Ethanol and Water Extracts from Germinated Rough Rice

Full Text Available

2010-03-01

371

Antioxidative Activity and Nitrite Scavenging Effect of the Composites Containing Medicinal Plant Extracts

Full Text Available

2010-08-01

372

Antioxidant and Anticancer Effects of Agrimony (Agrimonia pilosa L.) and Chinese Lizardtail (Saururus chinensis Baill)

Full Text Available

2007-08-01

373

Antioxidant Effect of Oil Containing Cellulase-Treated Red Ginseng.

Full Text Available

2008-06-01

374

Antimutagenic effects of browning products reacted with polyphenol oxidase extracted from peach

Full Text Available

2008-03-01

375

Antimicrobial Effect of Medicinal Plants against Methicillin-Resistant Staphylococcus aureus (MRSA)

Full Text Available

1992-04-01

376

Antihyperglycemia Effect of Medicinal Plants Mixture in Streptozotocin-Induced Diabetic Rats

Full Text Available

2007-03-01

377

Antidiabetic Effects of Leaves Extracts of Psidium guajava L. and Lagerstroemia speciosa L. in STZ-induced Rats

Full Text Available

2008-12-01

378

Anti-Oxidative Effects of Ulva lactuca Extract Fractions Against CCl4 Toxification

Full Text Available

2009-01-01

379

Analysis of the Effect of Water Budget Elements on Flow Duration Characteristics using SWAT-Nak Dong

Full Text Available

2006-12-01

380

An analytical study of linear and non-linear double diffusive convection with Soret and Dufour effects in couple stress fluid

Full Text Available

2007-03-01

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381

Ameliorating Effect of Capsaicin on Alterations in Lipid Metabolism during Mice Lung Carcinoma

Not Available

2007-09-01

382

Addition of electronic prescription transmission to computerized prescriber order entry: Effect on dispensing errors in community pharmacies.

Full Text Available

2009-02-01

383

APOPTOSIS INDUCER HAVING NEW INHIBITORY EFFECT ON INTRACELLULAR PARASITIC MICROORGANISM

PMID:21200064

2011-01-15

384

J-STORE (Japan)

Full Text Available

2006-11-10

385

ADULT ACQUIRED TOLERANCE TO HOMOGRAFTS.

A study of the Baldwin effect in the IUE data set

... The effectiveness of immune suppression with both 6-mercaptopurine and methotrexate was insufficient to permit induction of a clinically useful ...

1967-07-31

386

A numerical analysis of reaction-diffusion effects on species mixing rates in turbulent premixed methane-air combustion

The paper investigates the controversial relation between the continuum luminosity and the C IV 1550 emission-line strength in the spectra of quasars, commonly referred to as the Baldwin effect, as a possible indicator of absolute luminosity. It is concluded that the Baldwin effect does represent a physical correlation between the continuum and the C IV 1550 equivalent width rather than a consequence of selection effects. In addition to the C IV results, a similar relation is found for the Lyman-alpha emission line. 38 refs.

1990-07-01

387

A Study of the Histological Effects of Garlic Extract in a Liver-damage Rat Model

No abstract prepared.

2009-05-01

388

A STUDY ON THE AIR SCREEN IN WATER 1. Experiments on the Air Screen Effects for Driving and Intercepting Fish School

Full Text Available

2010-08-01

389

A Numerical Study on a Circulation Control Foil using Coanda Effect

Full Text Available

1972-06-01

390

A Comparative Study About the Effect of Nonablative Laser and Thermal energy on Rabbit Knee Joint Capsular Properties

Full Text Available

2000-05-01

391

The importance of axial effects for borehole design of geothermal heat-pump systems

Full Text Available

2001-06-01

392

Numerical analysis of methane-air combustion considering radiation effect

This paper studies the effects of axial heat conduction in boreholes used in geothermal heat pump systems. The axial effects are examined by comparing the results obtained using the finite and infinite line source methods. Using various practical design problems, it is shown that axial effects are relatively important. Unsurprisingly, short boreholes and unbalanced yearly ground loads lead to stronger axial effects. In one example considered, it is shown that the borehole length is 15% shorter when axial conduction effects are considered. In another example dealing with underground water freezing, the amount of energy that has to be removed to freeze the ground is three times higher when axial effects are considered. (author)

2010-04-15

393

Numerical analysis of methane-air combustion considering radiation effect

Turbulent premixed methane-air combustion in a cylindrical chamber is numerically simulated considering radiation effect. Reaction rates are considered as minimum rates between Arrhenius rates and eddy break up rates. A five step reduced mechanism is used. Turbulent modeling is done via standard k-{epsilon} model imposed by empirical inlet boundary conditions. Source terms of energy equation consist of reaction rates and radiation effects. The discrete ordinate method (DOM) is employed to solve the radiative transfer equation (RTE) and the weighted sum of gray gas model (WSGGM) is imposed to consider radiation effect of non-gray gases. The results indicate that in the case of turbulent combusting flows, the effect of radiation of gases can affect the temperature and species concentrations. The numerical results obtained considering radiation effect are closer to the experimental ...

2008-12-15

394

Biological effects of electromagnetic radiation in the microwave range

Turbulent premixed methane-air combustion in a cylindrical chamber is numerically simulated considering radiation effect. Reaction rates are considered as minimum rates between Arrhenius rates and eddy break up rates. A five step reduced mechanism is used. Turbulent modeling is done via standard k-? model imposed by empirical inlet boundary conditions. Source terms of energy equation consist of reaction rates and radiation effects. The discrete ordinate method (DOM) is employed to solve the radiative transfer equation (RTE) and the weighted sum of gray gas model (WSGGM) is imposed to consider radiation effect of non-gray gases. The results indicate that in the case of turbulent combusting flows, the effect of radiation of gases can affect the temperature and species concentrations. The numerical results obtained considering radiation effect are closer to the experimental data than ...

2008-12-01

395

Effect of humidity in a mixture on combustion (Part 1). Effect on laminar burning velocity

The book examines current experimental and clinical knowledge concerning the biological and biophysical effects of electromagnetic radiation, particularly that in the microwave range. The biophysical bases of the interaction of electromagnetic radiation with matter are reviewed with emphasis on biological systems, and the effects of radiation on critical biological systems, including the nervous, reproductive, visual and blood-forming systems are compared. Data concerning the lethal effects of nonionizing radiation is presented and characteristics of the effects of electromagnetic radiation on the whole mammalian organisms are examined. Various reactions of the neuroendocrine system to electromagnetic radiation are described, with particular attention given to the adrenal system, and the combined effects of ionizing and microwave radiation in the flight environment are discussed. ...

1980-01-01

396

The benefits of low level radiation

In order to investigate the effect of humidity on laminar burning velocity(S), the effect of humidity on the combustion reaction and radiation intensity was studied, taking account of dilution gases such as CO/sub 2/ and Ar which has the approximately identical characteristics to exhaust gas circulation(EGR) gas used to prevent NOx discharge from engines. According to the heat reaction theory, mean specific heat(C) of mixture, mean molecular weight(M) and adiabatic flame temperature(T) etc. were said to affect S but from experimental results, the effect of M and C could be ignored, compared with the effect of T. The relationship between S and H/sub 2/O, Ar of CO/sub 2/% in mixture of diluted gases was clarified. The effect of H/sub 2/O on S was mainly caused by changes of T. The effect of radical C/sub 2/, CH and OH on radiation intensity was similar to that of ...

1987-08-25

397

Nucleon and meson effective masses in the relativistic mean-field theory

The assumed linear relationship between exposure to radiation and cancer incidence is questioned in this article. The current research data on radiation effects at the cellular level is reviewed, as are epidemiological studies of background radiation effects and health effects of populations exposed to low levels of radiation exposure via employment or medical treatments. Statistics reveal that threshold levels currently in force need to be reviewed. Some evidence of beneficial effects of low level radiation exposure effects of low level radiation exposure is also presented, and so regulations should be reviewed at an international level. (UK).

1997-06-01

398

Nucleon and meson effective masses in the relativistic mean-field theory

Nucleon and meson effective masses in the nonlinear relativistic mean-field theory introducing a nonlinear {omega}-{rho} and {sigma} coupling motivated by the quark-meson coupling model is explored. It is shown that, in contrast to the usual Walecka model, not only the effective nucleon mass m{sub eff,N} but also the effective {sigma},{rho} meson masses (m{sub eff{sigma}},m{sub eff,{rho}}) and the effective {omega} meson mass m{sub eff,{omega}} are nucleon density dependent. (author)

2001-10-01

399

Gravitational Waves and the Sagnac Effect

Nucleon and meson effective masses in the nonlinear relativistic mean-field theory introducing a nonlinear #omega#-#rho# and #sigma# coupling motivated by the quark-meson coupling model is explored. It is shown that, in contrast to the usual Walecka model, not only the effective nucleon mass m_e_f_f_,_N but also the effective #sigma#,#rho# meson masses (m_e_f_f_#sigma#,m_e_f_f_,_#rho#) and the effective #omega# meson mass m_e_f_f_,_#omega# are nucleon density dependent. (author)

2001-10-01

400

Effects of focused ion beam milling on the nanomechanical behavior of a molybdenum-alloy single crystal

We consider light waves propagating clockwise and other light waves propagating counterclockwise around a closed path in a plane (theoretically with the help of stationary mirrors). The time difference between the two light propagating path orientations constitutes the Sagnac effect. The general relativistic expression for the Sagnac effect is discussed. It is shown that a gravitational wave incident to the light beams at an arbitrary angle will not induce a Sagnac effect so long as the wave length of the weak gravitational wave is long on the length scale of the closed light beam paths. The gravitational wave induced Sagnac effect is thereby null.

2003-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

Transuranium isotopes production and their effect on the three-dimensional core calculation

Nanoindentation was performed on a Mo-alloy single crystal to investigate effects of focused ion beam (FIB) milling on mechanical behavior. On a non-FIB-milled surface, pop-ins were observed on all load-displacement curves corresponding to a transition from elastic to plastic deformation. Similar pop-ins were not detected on surfaces subjected to FIB milling. This difference indicates that FIB milling introduces damage that obviates the need for dislocation nucleation during subsequent deformation. A second effect of FIB milling is that it increased the surface hardness. Together, these effects could be the source of the size effects reported in the literature on micropillar tests.

2007-09-10

402

Transuranium isotopes production and their effect on the three-dimensional core calculation

The operation of a nuclear power reactor necessarily implies the consumption or burnup of reactor fuel by fission and capture, which gives rise to a decrease in the reactivity of the reactor. The effect of americium formation on the criticality of a thermal power reactor using two types of fuel is studied. The three-dimensional core calculation is used to calculate the production of the transuranium isotopes and their effect on the effective multiplication factor (K[sub eff]). This effect cannot be neglected for thermal power reactors with UO[sub 2]-PuO[sub 2] fuel (3.11% after 70 weeks of operation). The effect of the transuranium isotopes on the K[sub eff] for a thermal power reactor with UO[sub 2] fuel is about 0.0018% and can be ignored. (author).

1993-02-01

403

Psychological ownership and affective reaction: Emotional attachment process variables and the endowment effect

The operation of a nuclear power reactor necessarily implies the consumption or burnup of reactor fuel by fission and capture, which gives rise to a decrease in the reactivity of the reactor. The effect of americium formation on the criticality of a thermal power reactor using two types of fuel is studied. The three-dimensional core calculation is used to calculate the production of the transuranium isotopes and their effect on the effective multiplication factor (K_e_f_f). This effect cannot be neglected for thermal power reactors with UO_2-PuO_2 fuel (3.11% after 70 weeks of operation). The effect of the transuranium isotopes on the K_e_f_f for a thermal power reactor with UO_2 fuel is about 0.0018% and can be ignored. (author).

404

British Library Electronic Table of Contents (United Kingdom)

This research proposes that the concept of emotional attachment, and specifically the independent constructs of psychological ownership and affective reaction, can help explain many of the endowment effect findings documented in the literature. We define these constructs and then test them across a set of nine studies in which we both replicate previous and generate new endowment effect findings, and then show that psychological ownership and affective reaction can mediate the effects. In doing so, we offer direct empirical support for the idea of emotional attachment as a driver of loss aversion while also providing practitioners and future endowment effect researchers with new insights about the psychological processes that underlie the endowment effect.

2011-01-01

405

Optical effects of fine-particle carbon on urban atmospheres

Numerical evaluation of effective unsaturated hydraulic properties for fractured rocks

The effects of fine-particle C, such as diesel soot, on the optical properties of urban haze in the visible wavelength range were explored to determine the dominant effects and to see if simple parameters (such as visual range in green) provide an adequate measure of these effects. It is known that fine-particle C absorbs more strongly in the blue than in the red, so that when it is mixed with a white pigment, the resulting gray can appear somewhat brown. The possibility of a similar effect in urban hazes was investigated, but found not to occur. When the sun is overhead, the near-horizon sky chromaticities caused by mixtures of fine-particle C and non-absorbing aerosol can also be produced by non-absorbing aerosols alone. It is shown that absorbing aerosol will darken the horizon sky, and a simple equation for the radiance of the horizon sky is derived. The effect of absorbing ...

1986-01-01

406

Locally resonant acoustic metamaterials with 2D anisotropic effective mass density

To represent a heterogeneous unsaturated fractured rock by its homogeneous equivalent, Monte Carlo simulations are used to obtain upscaled (effective) flow properties. In this study, we present a numerical procedure for upscaling the van Genuchten parameters of unsaturated fractured rocks by conducting Monte Carlo simulations of the unsaturated flow in a domain under gravity-dominated regime. The simulation domain can be chosen as the scale of block size in the field-scale modeling. The effective conductivity is computed from the steady-state flux at the lower boundary and plotted as a function of the averaging pressure head or saturation over the domain. The scatter plot is then fitted using van Genuchten model and three parameters, i.e., the saturated conductivity K{sub s}, the air-entry parameter {alpha}, the pore-size distribution parameter n, corresponding to this model are considered as the effective K{sub s}, ...

2009-01-01

407

British Library Electronic Table of Contents (United Kingdom)

A two-dimensional (2D) lattice model with anisotropic resonant microstructures is found to provide an anisotropic band gap structure. A 2D continuum with anisotropic effective mass density is introduced to represent this lattice system. Two methods are proposed to derive the equivalent continuum. In the first method, the effective mass density of the equivalent continuum is obtained by matching the dispersion relations for harmonic waves propagating in the principal directions. The second approach employs an approximate estimation of the effective mass density by volume-averaging an effective mass that represents the resonant microstructure. For both equivalent continuum models, the effective mass density is frequency-dependent and may become negative in certain frequency ranges. Subsequen...

2011-01-01

408

Hepatoprotective and anti-hepatocarcinogenic effects of glycyrrhizin and matrine

British Library Electronic Table of Contents (United Kingdom)

Matrine (Mat), a component extracted from Sophora flavescens Ait, has a wide spectrum of pharmacological effects. Glycyrrhizin (Gly), a major active constituent of licorice (Glycyrrhiza glabra) root, has various pharmacological effects. Gly and Mat are ancillary drugs used clinically in China for protection of liver function and treatment of tumors. However, habitual administration of Gly may cause adverse effects marked by the development of pseudohypercorticosteroidism. This work was designed to see whether combination use of Gly and Mat could offer better liver protective and anti-hepatocarcinogenic effects than Gly or Mat alone, and whether it could reduce the adverse effects of Gly alone by acetaminophen-induced hepatotoxicity, diethylnitrosamine-induced hepatocarcinogenesis, inductio...

2009-01-01

409

Field tests on partial embedment effects (embedment effect tests on soil-structure interaction)

Effective dose equivalent concept in radiopharmaceutical dosimetry

A series of Model Tests of Embedment Effect on Reactor Buildings has been carried out by the Nuclear Power Engineering Corporation (NUPEC), under the sponsorship of the Ministry of International Trade and lndustry (MITI) of Japan. The nuclear reactor buildings are partially embedded due to conditions for the construction or building arrangement in Japan. It is necessary to verify the partial embedment effects by experiments and analytical studies in order to incorporate the effects in the seismic design. Forced vibration tests, therefore, were performed using a model with several types of embedment. Correlated simulation analyses were also performed and the characteristics of partial embedment effects on soil-structure interaction were evaluated. (author)

1993-08-15

410

Effective dose equivalent concept in radiopharmaceutical dosimetry

The Effective Dose Equivalent Concept defined by the International Commission on Radiological Protection in 1977 considers the risk from irradiation including both hereditary and somatic effects. This paper will deal with the definition of a concept for somatic effects only, the somatically significant dose equivalent. This is defined as the dose equivalent which if received by every member of the population, would be expected to produce the same total somatic injury to the population as does the actual dose equivalent received by various individuals. The somatically effective dose equivalent for a particular radiopharmaceutical is the weighted sum of the average dose equivalent to various organs. The dose equivalent to various organs can be derived from an extended MIRD formalism also considering the rest of body excluding the source volumes and the re iden e times in total body and the target organs. ...

1981-06-01

411

Cost-effectiveness analysis for proposed effluent limitations guidelines and standards for the coastal subcategory of the oil and gas extraction point source category

The Effective Dose Equivalent Concept defined by the International Commission on Radiological Protection in 1977 considers the risk from irradiation including both hereditary and somatic effects. This paper will deal with the definition of a concept for somatic effects only, the somatically significant dose equivalent. This is defined as the dose equivalent which if received by every member of the population, would be expected to produce the same total somatic injury to the population as does the actual dose equivalent received by various individuals. The somatically effective dose equivalent for a particular radiopharmaceutical is the weighted sum of the average dose equivalent to various organs. The dose equivalent to various organs can be derived from an extended MIRD formalism also considering the rest of body excluding the source volumes and the re iden e times in total body and the target organs. ...

412

A hybrid solar desalination process of the multi-effect humidification dehumidification and basin-type unit

The analysis is submitted in support of the effluent limitations guidelines and standards for the Coastal Oil and Gas Industry. The report analyzes the cost-effectiveness of 10 regulatory options organized by three wastestreams. The document compares the total annualized cost incurred for each of the regulatory options within each wastestream to the corresponding effectiveness of that option in reducing the discharge of pollutants. Section Two discusses the cost-effectiveness methodology used and identifies the pollutants included in the analysis, presenting their toxic weighting factors and removal efficiencies. Section Three presents the results of the analysis. In Section Four, the cost-effectiveness values are compared to cost-effectiveness values for other promulgated rules. Appendix A presents data on pollutants, pollutant removals, annualized costs, and other, more detailed ...

1995-01-01

413

British Library Electronic Table of Contents (United Kingdom)

This paper presents a hybrid solar desalination process of the multi-effect humidification dehumidification and the basin-type unit. The sketch of the hybrid solar desalination process is given. The solar vacuated tube collector is employed in the desalination system, multi-effect humidification dehumidification desalination (HDD) process is plotted according to pinch technology, and then the water rejected from multi-effect HDD process is reused to desalinate in a basin-type unit further. The gain output ratio (GOR) of this system will rise by 2?3 at least through reusing the rejected water. The research proves that the multi-effect HDD has much room to be improved. A hybrid solar desalination process of the multi-effect humidification dehumidification and the basin-type unit should be no...

2008-01-01

414

Health effects models for nuclear power plant accident consequence analysis. Modification of models resulting from addition of effects of exposure to alpha-emitting radionuclides: Revision 1, Part 2, Scientific bases for health effects models, Addendum 2

X-ray dose enhancement effects

The Nuclear Regulatory Commission (NRC) has sponsored several studies to identify and quantify, through the use of models, the potential health effects of accidental releases of radionuclides from nuclear power plants. The Reactor Safety Study provided the basis for most of the earlier estimates related to these health effects. Subsequent efforts by NRC-supported groups resulted in improved health effects models that were published in the report entitled {open_quotes}Health Effects Models for Nuclear Power Plant Consequence Analysis{close_quotes}, NUREG/CR-4214, 1985 and revised further in the 1989 report NUREG/CR-4214, Rev. 1, Part 2. The health effects models presented in the 1989 NUREG/CR-4214 report were developed for exposure to low-linear energy transfer (LET) (beta and gamma) radiation based on the best scientific information available at that time. Since the 1989 report was ...

1993-05-01

415

Uncovering the Mechanisms of Estrogen Effects on Hippocampal Function

A brief description of the physical process of dose enhancement effects produced by X-ray radiation on materials is given, with emphasis on the influence on electronic devices. The damages caused by X-ray radiation dose enhancement is more serious than that of #gamma#-ray with higher energy.

416

The impact of water intake on energy intake and weight status: a systematic review

Estrogens have direct effects on the brain areas controlling cognition. One of the most studied of these regions is the dorsal hippocampal formation, which governs the formation of spatial and...Full Text Available

2008-05-01

417

The effects of thiamin on lead metabolism: organ distribution of lead 203.

The effects of consuming water with meals rather than drinking no beverage or various other beverages remains under-studied. This systematic review of English language studies compared the effects...Full Text Available

2010-09-01

418

The effects of an HIV project on HIV and non-HIV services at local government clinics in urban Kampala

The effect of thiamin on the organ distribution of lead was evaluated in CD-1 mice exposed intragastrically or intraperitoneally to a single dose of lead acetate (100 micrograms) containing 100 microCi...Full Text Available

1992-07-01

419

The effect of lipopolysaccharide on bovine mammary macrophage function.

BackgroundHIV/AIDS is a major public health concern in Uganda. There is widespread consensus that weak health systems hamper the effective provision of HIV/AIDS services. In recent...Full Text Available

420

The effect of diphenylhydantoin on thyroxine metabolism in man

The effect of Escherichia coli lipopolysaccharide (LPS) on the expression of major histocompatibility complex (MHC) class II molecules by bovine mammary macrophages was examined. The ability of LPS-treated...Full Text Available

1991-07-01

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421

The Mechanism and the Magnitude of Flow Boiling Augmentation in Tubes with Discrete Surface Roughness Elements (III).

The effect of 5,5′-diphenylhydantoin on thyroxine metabolism was examined in five normal volunteers. Intravenous injection of radiothyroxine was followed by a 10-12 day control and subsequent...Full Text Available

1970-06-01

422

The Effect of Reference Signals in a Visual Vigilance Task.

Related to other research on the effectiveness of flow boiling heat transfer augmentation using various types of turbulators this investigation comprises a definitive study of the effect of large discrete roughness elements on heat transfer over the entir...

1972-01-01

423

The Effect of Live Classical Piano Music on the Vital Signs of Patients Undergoing Ophthalmic Surgery

The effect of reference signals on performance in a visual vigilance task was studied under three conditions. Reference signals were presented on the same display as the real signals. In condition 1 (control), no reference signals were displayed. Sugbject...

1969-01-01

424

The Effect of Lindane Formulations on Tissue Residues in Barrows and on Stillbirths in Sows

ContextMusic and surgery.ObjectiveTo determine the effect of live classical piano music on vital signs of patients undergoing ophthalmic surgery.DesignRetrospective...Full Text Available

425

The Effect of Different Timber Harvesting Techniques on Plethadontid Salamander Populations.

The potential effect of lindane and its formulations on stillbirths and abortion in pregnant sows was investigated. One of four formulations of lindane were applied at five times the registered dosage...Full Text Available

1986-01-01

426

THE EFFECTS OF RESPONSE EFFORT ON SAFE PERFORMANCE BY THERAPISTS AT AN AUTISM TREATMENT FACILITY

This investigation will explore the effect that current timber extraction techniques have on plethadontid salamander populations in ... group selection, and two-age harvest. Broad scale timber extraction can d...

427

Some aspects of the pharmacology of an homologous series of choline esters of fatty acids

The effects of response effort on safe behaviors (i.e., glove wearing, hand sanitizing, and electrical outlet replacement) exhibited by therapists at an autism treatment center were examined. Participants...Full Text Available

2010-01-01

428

Sexual differentiation of the zebra finch song system: potential roles for sex chromosome genes

The pharmacological effects of a series of fatty acid-choline esters have been studied on the isolated rabbit heart, the isolated guinea-pig ileum and the rat stomach. The effect changed with increasing...Full Text Available

1957-03-01

429

Sequential effects in two-choice reaction time tasks: Decomposition and synthesis of mechanisms

BackgroundRecent evidence suggests that some sex differences in brain and behavior might result from direct genetic effects, and not solely the result of the organizational effects...Full Text Available

430

Seasonal and Annual Variation in Activity in Wild Male Meadow Voles (Microtus Pennsylvanicus).

Performance on serial tasks is influenced by first- and higher-order sequential effects, respectively due to the immediately previous and earlier trials. As response-to-stimulus interval (RSI)...Full Text Available

2009-09-01

431

Reproductive Success of Cavity-nesting Birds Breeding under High-voltage Powerlines

Project ZEUS was designed to characterize the effects of long-term gamma irradiation on free-ranging meadow voles, and to determine the lowest level of radiation at which biological effects are discernible in the population. Behavioural tests are consider...

1980-01-01

432

Protective effects of hydroalcoholic extract from rhizomes of Cynodon dactylon (L.) Pers. on compensated right heart failure in rats

... biological effects of electromagnetic fields (EMFs) produced by high-voltage transmission lines have come under intense scrutiny, mostly with respect ... biological effects of electromagnetic fields (EMFs...

433

Project resumes: biological effects from electric fields associated with high-voltage transmission lines

BackgroundThe rhizomes of Cynodon dactylon are used for the treatment of heart failure in folk medicine. In the present study, we investigated the effects of hydroalcoholic...Full Text Available

434

Phase transitions in the soliton star model

Abstracts of research projects are presented in the following areas: measurements and special facilities; cellular and subcellular studies; physiology; behavior; environmental effects; modeling, scaling and dosimetry; and high voltage direct current. (ACR)

1980-01-01

435

Pharmacologically Induced Hypogonadism and Sexual Function in Healthy Young Women and Men

The aim of this paper is to obtain the effective potential of the non-topological soliton model at finite temperature with the assumption that the chemical potential {mu} of the system is different from zero and to analyse how the effective potential is influenced by changes in the chemical potential and temperature. (author)

1998-01-01

436

On the temperature dependence of the level density parameter and its effect upon neutron evaporation spectra

Studies fail to find uniform effects of age-related or induced hypogonadism on human sexual function. We examined the effects of induced hypogonadism on sexual function in healthy men and women...Full Text Available

2009-02-01

437

On the chiral effective meson-baryon Lagrangian at third order{sup *}

Effects associated with the temperature dependence of the level density parameter, a(T), are investigated in connection with neutron evaporation processes. Different approximations, for this temperature dependence, are compared for the case of neutron emission from the compound nucleus /sup 209/Pb.

1987-07-01

438

Near-infrared spectroscopy technique to evaluate the effects of red blood cell transfusion on tissue oxygenation

We show that the recently constructed complete and ''minimal'' third-order meson-baryon effective chiral Lagrangian can be further reduced from 84 to 78 independent operators. (orig.)

2006-09-15

439

Long-term effects of inhaled uranyl nitrate in rats

IntroductionThe aim of this study was to evaluate the effects of red blood cell (RBC) transfusions on muscle tissue oxygenation, oxygen metabolism and microvascular reactivity in...Full Text Available

2009-01-01

440

Immediate and residual effects in man of the metabolites of diazepam

Rats were exposed to aerosols of "2"3"3U and "2"3"2U nitrate in a study of the long-term biological effects. Preliminary radiation dose estimates show lung > skeleton > kidney in each dose group.

1977-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

Healthy worker effect in the total Finnish population.

1 Immediate and residual effects of diazepam and its metabolites on visuomotor co-ordination have been studied in man. Performance was observed from 10.0-16.0 h after overnight ingestion...Full Text Available

1978-10-01

442

The selection due to the "healthy worker effect" was estimated from a random sample of the total Finnish population. The sample of 20 000 people was followed for changes in occupations from 1960 to...Full Text Available

1980-05-01

443

Health effects of air pollutants: sulfuric acid, the old and the new.

Objective To compile and evaluate the evidence on the effects on health and social outcomes of computer based peer to peer communities and electronic self support groups, used by people...Full Text Available

2004-05-15

444

H-1152 Effects on Intraocular Pressure and Trabecular Meshwork Morphology of Rat Eyes

Data from exposure of experimental animals and human subjects to sulfuric acid presents a consistent picture of its toxicology. Effects on airway resistance in asthmatic subjects were well predicted...Full Text Available

1989-05-01

445

AbstractPurposeThe aim of this study was to elucidate the effects of the Rho-kinase inhibitor, H-1152, on cultured human trabecular meshwork (HTM) cells, TM morphology,...Full Text Available

2008-08-01

446

Guidelines on exchangers

Genetic association between the COMT genotype and urinary levels of tea polyphenols and their metabolites among daily green tea drinkers

Experience has shown that a list of tips provides designers and engineers with an effective guide in their areas of duties and concern. This list contains new and rare information on heat exchangers and heat recovery systems. The information presented can be used effectively with personal computers and pocket calculators and also conveniently translated into computer programs and nomographs.

1985-08-01

447

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

Available in vitro and animal studies have shown cancer protective effects of tea polyphenols. Recent study suggests a greater protective effect of green tea intake on breast cancer...Full Text Available

448

Flucton model with scaling breaking: EMC effect and lepton pair production on nuclei

Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It is possible that the life-prolonging effects...Full Text Available

449

Female rats display dose-dependent differences to the rewarding and aversive effects of nicotine in an age-, hormone-, and sex-dependent manner

The EMS effect is explained in the flucton model as a consequence of scale invariance violation. Nontrivial behaviour of the ratio between structural functions and production cross sections for lepton pairs for different nuclei at x > 1 is predicted.

450

FURTHER EVALUATION OF RESPONSE INTERRUPTION AND REDIRECTION AS TREATMENT FOR STEREOTYPY

IntroductionThe objective of this study was to examine age-, hormone-, and sex-dependent differences to the behavioral effects of nicotine using place-conditioning...Full Text Available

2009-10-01

451

Exposure to nitroaromatic explosives and health effects during disposal of military waste

The effects of 2 forms of response interruption and redirection (RIRD)—motor RIRD and vocal RIRD—were examined with 4 boys with autism to evaluate further the effects of this intervention...Full Text Available

2011-01-01

452

Estimation of effective population sizes from data on genetic markers

Aims: To investigate the exposure to dinitrotoluene (DNT) and trinitrotoluene (TNT) and the resulting effects in workers which occur during the disposal of military waste. Methods:...Full Text Available

2003-07-01

453

Erythrocyte transketolase activity in suspected cases of Leigh's disease, or subacute necrotising encephalomyelopathy.

The effective population size (N_e) is an important parameter in ecology, evolutionary biology and conservation biology. It is, however, notoriously difficult to estimate,...Full Text Available

2005-07-29

454

Environmental Effects and Energy Efficiency in Building Design: A Green Building Approach. Part 2. Basic Data for Environmental Effects.

Erythrocyte transketolase activity and the effect of adding thiamine pyrophosphate (% thiamine pyrophosphate effect) were measured in 111 subjects suspected to suffer from Leigh's disease (subacute...Full Text Available

1980-10-01

455

Endocrine and Neurochemical Effects of 3,4-Methylenedioxymethamphetamine and Its Stereoisomers in Rhesus Monkeys

The development of comfort in buildings throughout the centuries was influenced by the demand for progress, wealth and innovation in various respects. At present, it seems that progress may only be possible by taking into account the environment and creat...

1993-01-01

456

Efficacy of standard glucose-based and reduced-osmolarity maltodextrin-based oral rehydration solutions: effect of sugar malabsorption.

3,4-Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative that elicits complex biological effects in humans. One plausible mechanism for this phenomenon is that racemic MDMA is composed...Full Text Available

2010-08-01

457

Effects of gonadotrophin releasing hormone on reproductive performance of dairy cows with retained placenta.

Previously we reported that standard oral rehydration salts (ORS) solution is not as effective as a reduced-osmolarity glucose-based ORS for the treatment of children with acute noncholera diarrhoea:...Full Text Available

1996-01-01

458

Effects of bovine leukemia virus infection on production and reproduction in dairy cattle.

The effects of gonadotrophin releasing hormone (GnRH) on the reproductive performance of dairy cows with retained placenta were studied. Three hundred and seventy-eight cows diagnosed as having retained...Full Text Available

1984-10-01

459

Effects of biotin supplementation on serum biotin levels and physical properties of samples of solar horn of Holstein cows

The purpose of this study was to determine the effects of bovine leukemia virus (BLV) infection on production, reproduction and longevity in dairy cattle. The study population was a commercial Holstein...Full Text Available

1992-10-01

460

Effects of ammonia and hydrogen sulfide on physical and biochemical properties of the claw horn of Holstein cows

AbstractEffects of dietary biotin supplementation on serum biotin levels and physical properties of sole horn of 40 Holstein cows were evaluated. The mean serum biotin level in biotin-supplemented...Full Text Available

2004-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

Effects of acute dieldrin exposure on neurotransmitters and global gene transcription in largemouth bass (Micropterus salmoides) hypothalamus

The effects of ammonia and hydrogen sulfide on the physical and biochemical properties of the claw horn of Holstein cows were evaluated. Significant (P < 0.05, 0.01) decreases...Full Text Available

2009-01-01

462

Effects of a community mental health service on the practice and attitudes of general practitioners.

Exposure to dieldrin induces neurotoxic effects in the vertebrate CNS and disrupts reproductive processes in teleost fish. Reproductive impairment observed in fish by dieldrin is likely the...Full Text Available

2010-08-01

463

Effects of Intrathecal Baclofen on Perceived Sexual Functioning in Men With Spinal Cord Injury

Recent years have seen closer links developing between general practitioners and mental health specialists. A study was undertaken in Manchester to determine the effects of a new community mental health...Full Text Available

1993-12-01

464

Effects of Daily Morphine Administration and Deprivation on Choice and Demand for Remifentanil and Cocaine in Rhesus Monkeys

Background/Objective:Reports in the literature suggest that administration of intrathecal baclofen to control spasticity may have deleterious effects on erectile function...Full Text Available

2008-01-01

465

Effects of Age on Optical Coherence Tomography Measurements of Healthy Retinal Nerve Fiber Layer, Macula and Optic Nerve Head

Choice procedures have indicated that the relative reinforcing effectiveness of opioid drugs increases during opioid withdrawal. The demand curve, an absolute measure of reinforcer value, has not been...Full Text Available

2011-01-01

466

Effective Reduced Diffusion-Models: A Data Driven Approach to the Analysis of Neuronal Dynamics

PurposeTo determine the effects of age on global and sectoral peripapillary retinal nerve fiber layer (RNFL), macular thicknesses and optic nerve head (ONH) parameters...Full Text Available

2009-06-01

467

Effect of misonidazole pretreatment on nitrogen mustard-induced DNA cross-linking in mouse tissues in vivo.

We introduce in this paper a new method for reducing neurodynamical data to an effective diffusion equation, either experimentally or using simulations of biophysically detailed models. The dimensionality...Full Text Available

2009-12-01

468

Effect of mineral compounds in phosphoric acid polluted by sulfide ions on corrosion of nickel

In the present study we have used the alkaline elution technique to study the effect of misonidazole (MISO) on the initial amount of DNA cross-linking in various normal and neoplastic tissues of C3H...Full Text Available

1984-12-01

469

Effect of long-term caloric restriction on oxygen consumption and body temperature in two different strains of mice

The inhibiting effects of two mineral compounds on corrosion of nickel in phosphoric acid (H[sub 3]PO[sub 4]) polluted by sulfide ions (S[sup 2[minus

1999-06-01

470

Effect of lead on erythrocyte membranes.

The hypothesis, that a decrease in metabolic rate mediates the life span prolonging effect of caloric restriction (CR), was tested using two strains of mice, one of which, C57BL/6, exhibits...Full Text Available

2007-10-01

471

Effect of household and village characteristics on financial catastrophe and impoverishment due to health care spending in Western and Central Rural China: A multilevel analysis

The effect of blood lead on erythrocyte membrane proteins was studied in 28 workers from a scrap lead refining factory and in 18 controls working in railway construction. Sodium dodecyl sulphate-polyacrylamide...Full Text Available

1983-05-01

472

Effect of forced swimming stress on in-vivo fertilization capacity of rat and subsequent offspring quality

ObjectiveThe study aimed to examine the effect of household and community characteristics on financial catastrophe and impoverishment due to health payment in Western and Central...Full Text Available

473

Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice

AIMS:This study aimed to determine the effect of 50 days of forced swimming stress on fertilization capacity of rat and subsequent offspring quality.SETTING...Full Text Available

2010-01-01

474

Effect of association processes on polymerization of N-[3-(dimethylamino)propyl]methacrylamide salts in aqueous solutions

Chemoprevention strategies to prevent the development of lung cancer in at-risk individuals are a key component in disease management. In addition to being highly effective, an ideal chemopreventive...Full Text Available

2008-08-01

475

British Library Electronic Table of Contents (United Kingdom)

The effect of associative interactions of monomers and propagating macroradicals in homopolymerization of N-[3-(dimethylamino)propyl]methacrylamide salts and their copolymerization with acrylonitrile and acrylamide in aqueous solution was studied.

2010-01-01

476

Effect of Peroxisome Proliferator-Activated Receptor Gamma Agonist (Pioglitazone) and Methotrexate on Disease Activity in Rheumatoid Arthritis (Experimental and Clinical Study)

Effect of Heat Treatment on Some Mechanical Properties of Laminated Window Profiles Manufactured Using Two Types of Adhesives

Objective:To investigate the combined effect of both pioglitazone and methotrexate on disease activity of rheumatoid arthritis in a biphasic study; experimental and clinical.Methods:Experimentally:...Full Text Available

477

Effect of Anionic Salt and Highly Fermentable Carbohydrate Supplementations on Urine pH and on Experimentally Induced Hypocalcaemia in Cows

The mechanical properties of laminated window profiles manufactured using two types of adhesives were determined. The objective of this study is to evaluate the effects of heat treatment on some mechanical...Full Text Available

478

Effect of #gamma#-irradiation on relaxation properties of sealants on organosilicon rubber base

The objective of this experiment was to determine the effect of dietary grain on calcium homeostasis. Six rumen-fistulated dairy cows with 3 or more previous lactations and no history of parturient...Full Text Available

2004-01-01

479

Ecological relevance of air pollution abatement measures as a decision aid

The dielectrical properties of organosilicon sealants have been studied in the wide range of temperatures in the low and radio frequencies range. The effect of thermal treatment and #gamma#-irradiation on these properties is discussed.

480

EFFECT OF THE DIGENEAN PARASITE PROTEROMETRA MACROSTOMA ON HOST MORPHOLOGY IN THE FRESHWATER SNAIL ELIMIA LIVESCENS

Air pollution abatement measures are not an end in themselves, and undesirable side effects should be taken into account. The proposed emission index takes into account the total emissions caused by a technical project as well as the effects of the individual pollutants.

1983-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

481

DISPERSION TOLERANCE CALCULATION FOR NSLS-II.

... 1984; Martin-Mora et al., 1995), and parasitism (Rothschild and Rothschild, 1939; Pesigan et al., 1958; Moose, 1963; Pan, ... effects of digeneans are variable; they may enhance (Rothschild and Rothschild...

482

Cost-Effectiveness Analysis of Proposed Effluent Limitations Guidelines and Standards for the Pesticide Manufacturing Industry.

In this paper we discuss the effect on the emittance of the residual dispersion in the insertion devices. The dispersion in the straights could be generated by the lattice error, trim dipole, and insertion device. The effect on the emittance is examined, and the dispersion tolerances are given for the NSLS-11.

2007-06-25

483

Cost-Effectiveness Analysis of Proposed Effluent Limitations Guidelines and Standards for the Centralized Waste Treatment Industry.

The report analyzes the cost-effectiveness of two alternative regulatory options: A Treated Discharge Option and a Zero Discharge Option. The report compares the total annualized cost incurred for each of the two regulatory options to the corresponding ef...

1992-01-01

484

Comparison of the Maturation of the Adrenergic and Serotonergic Neurotransmitter Systems in the Brain: Implications for Differential Drug Effects on Juveniles and Adults

This analysis, submitted in support of proposed effluent limitations guidelines and standards for the centralized waste treatment (CWT) industry, investigates the cost-effectiveness of 24 regulatory options, representing all possible combinations of nine ...

1995-01-01

485

Comparative analysis of cis-regulation following stroke and seizures in subspaces of conserved eigensystems

Our understanding of the development of neurotransmitter systems in the central nervous system has increased greatly over the past three decades and it has become apparent that drug effects...Full Text Available

2007-04-15

486

Characterization of the stimulatory effect of high-fat diets on peroxisomal beta-oxidation in rat liver.

BackgroundIt is often desirable to separate effects of different regulators on gene expression, or to identify effects of the same regulator across several systems. Here, we focus...Full Text Available

487

Changes in health utilities and health-related quality of life over 12 months following radical prostatectomy

1. The effect on rat liver peroxisomal beta-oxidation of feeding diets containing various amounts of dietary oils was investigated. With increasing amounts (5-25%, w/w) of soya-bean oil an apparent,...Full Text Available

1982-08-15

488

CDDO-Me: A Novel Synthetic Triterpenoid for the Treatment of Pancreatic Cancer

Introduction:Although radical prostatectomy (RP) is an effective treatment for prostate cancer, it has potentially deleterious effects on health-related quality of life (HRQoL)....Full Text Available

2009-12-01

489

Biomarkers Signal Contaminant Effects on the Organs of English Sole (Parophrys vetulus) from Puget Sound

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancy with dismal prognosis and few effective therapeutic options. Novel agents that are safe and effective are urgently...Full Text Available

2010-12-01

490

Benzyl carbamyl analogue of lignocaine: vasodepressor mechanism of action.

Fish living in contaminated environments accumulate toxic chemicals in their tissues. Biomarkers are needed to identify the resulting health effects, particularly focusing on early changes at a subcellular...Full Text Available

2006-06-01

491

Attenuation of Cocaine's Reinforcing and Discriminative Stimulus Effects via Muscarinic M₁ Acetylcholine Receptor StimulationS?

1. The benzyl carbamyl analogue of lignocaine [2-(diethylaminoacetamido)-3-carbamyl-4-methyl-5-benzylpyrrole] at an intravenous dose of 4 mg/kg caused a blood pressure decrease of 54 mmHg. 2. A greater hypotensive effect was observed in hypertensive compared to normotensive animals. Anaesthesia magnified the vasodepressor effect in both groups. 3. The analogue did not possess centrally-mediated effects on blood pressure but exerted its hypotensive effect via a peripheral mechanism. 4. The analogue produced a relaxant effect on intestinal and vascular smooth muscle while exerting minimal effects on muscarinic, sympathetic, or ganglionic nicotinic receptors. 5. The analogue exhibited less cardiac depressant action on left ventricular rate (dp/dt) and force of contraction than lignocaine. 6. Lethal effects for the analogue were first observed ...

492

Assessing and Compensating for Zero-lag Correlation Effects in Time-lagged Granger Causality Analysis of fMRI

Muscarinic cholinergic receptors modulate dopaminergic function in brain pathways thought to mediate cocaine's abuse-related effects. Here, we sought to confirm and ...Full Text Available

2010-01-01

493

An argument for the chicken embryo as a model for the developmental toxicological effects of the polyhalogenated aromatic hydrocarbons (PHAHs)

Effective connectivity in brain networks can be studied using Granger causality analysis which is based on temporal precedence, while functional connectivity is usually derived using zero-lag...Full Text Available

2010-06-01

494

Actual and Potential Effects of Medical Resident Coverage on Reimbursement for Inpatient Visits by Attending Physicians

This article will present the argument that the chicken embryo is especially appropriate as an animal model for studying the mechanism of the developmental toxicological effects of the polyhalogenated aromatic hydrocarbons (PHAHs). The PHAHs are a group of toxicologically related compounds including, in part, the polychlorinated dibenzodioxins, dibenzofurans and biphenyls. The chicken (Gallus gallus) embryo is relatively sensitive to the toxicological effects of the PHAHs being approximately two orders of magnitude more sensitive than the mature bird. The chicken embryo has been used to demonstrate general toxicological teratogeneicity, hepatotoxicity and neurotoxicity. Many of these effects, or analogous effects, have also been observed in mammals and fish. Thus, most animals appear to respond to the PHAHs with a similar toxicological profile, indicating that many of the biomarkers used for the PHAHs ...

1996-12-31

495

Access Intervention in an Integrated, Prepaid Group Practice: Effects on Primary Care Physician Productivity

CONTEXTThe impact of residents on hospital finance has been studied; there are no data describing the economic effect of residents on attending physicians.OBJECTIVEIn...Full Text Available

2002-06-01

496

A tool to balance benefit and harm when deciding about adjuvant therapy

ObjectiveTo estimate the joint effect of a multifaceted access intervention on primary care physician (PCP) productivity in a large, integrated prepaid group practice.Data...Full Text Available

2008-10-01

497

A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction

Adjuvant therapy aims to prevent outgrowth of residual disease but can induce serious side effects. Weighing conflicting treatment effects and communicating this information with patients is not elementary....Full Text Available

2009-03-24

498

A Motivation-Focused Weight Loss Maintenance Program is an Effective Alternative to a Skill-Based Approach

Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70. Treatment with PDE-5 inhibitors is effective in the majority of men with ED. However, PDE-5 inhibitors are not effective...Full Text Available

2010-01-01

499