UK PubMed Central (United Kingdom)

The exocyst is an evolutionarily conserved octameric complex involved in polarized exocytosis from yeast to humans. The Sec3 subunit of the exocyst acts as a spatial landmark for exocytosis through...Full Text Available

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Background: Thyroid-stimulating autoantibodies (TSAb) bind to the thyrotropin receptor (TSHR) extracellular domain, or ectodomain (ECD), comprising a leucine-rich repeat domain (LRD) linked by a hinge region to the transmembrane domain (TMD). The LRD (residues 22???260; signal peptide 1???21) contains two disulfide-bonded loops at its N-terminus. In the crystal structure of the isolated LRD complexed with human TSAb monoclonal antibody (mAb) M22, N-terminal disulfide loop 1 (residues 22???30) could not be determined because of crystal disorder. Nevertheless, present crystal structure data are interpreted to exclude a role for the LRD N-terminal disulfide loops in the TSAb epitope(s), contradicting prior functional evidence of a role for these loops in TSAb function. Materials and Methods: ...

UK PubMed Central (United Kingdom)

The p90 ribosomal S6 kinases (RSKs) also known as MAPKAP-Ks are serine/threonine protein kinases that are activated by ERK or PDK1 and act as downstream effectors of mitogen-activated protein kinase...Full Text Available

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SR proteins are essential splicing factors whose function is controlled by multi-site phosphorylation of a C-terminal domain rich in arginine-serine repeats (RS domain). The protein kinase SRPK1 has been shown to polyphosphorylate the N-terminal portion of the RS domain (RS1) of the SR protein ASF/SF2, a modification that promotes nuclear entry of this splicing factor and engagement in splicing function. Later, dephosphorylation is required for maturation of the spliceosome and other RNA processing steps. While phosphates are attached to RS1 in a sequential manner by SRPK1, little is known about how they are removed. To investigate factors that control dephosphorylation, we monitored region-specific mapping of phosphorylation sites in ASF/SF2 as a function of the protein phosphatase PP1. W...

Science.gov (United States)

In view of the findings that several Kunitz-type protein inhibitors suppress tumor invasion and metastasis, the aim of the present study is to explore whether Bungarus multicinctus protease inhibitor-like protein-2 (PILP-2) and PILP-3 exhibit anti-tumor activity. Although approximately 28% of amino acid substitutions occurred between PILP-2 and PILP-3, molecular modeling suggested that PILP-2 and PILP-3 shared similar folded structures. Unlike PILP-2, PILP-3 showed a notable activity in abolishing migration and invasion of human neuroblastoma SK-N-SH cells. The ability of PILP-3 to inhibit matrix metalloprotease-2 (MMP-2) activity was higher than that of PILP-2. Pull-down assay revealed protein-protein interaction between PILP-3 and MMP-2. In contrast to mutation on N-terminal region, replacement of amino acids at C-terminus attenuated notably the ability of PILP-3 to inhibit cell invasion, cell migration and MMP-2 activity as well as the binding capability of ...

Energy Technology Data Exchange (ETDEWEB)

Amino acids other than those that serve as ligands have been found to influence the chemical properties of transferrin iron. The catalytic ability of pyrophosphate to mediate transferrin iron release to a terminal acceptor is largely quenched by modification non-liganded histine groups on the protein. The first order rate constants of iron release for several partially histidine modified protein samples were measured. A statistical method was employed to establish that one non-liganded histidine per metal binding domain was responsible for the reduction in rate constant. These results imply that the iron mediated chelator, pyrophosphate, binds directly to a histidine residue on the protein during the iron release process. EPR spectroscopic results are consistent with this interpretation. Kinetic and amino acid sequence studies of ovotransferrin and lactoferrin, in addition to human serum transferrin, have allowed the tentative assignment of His-207 in the ...

UK PubMed Central (United Kingdom)

c-Jun N-terminal kinase 2 (JNK2) isoforms are transcribed from the jnk2 gene and are highly homologous with jnk1 and jnk3 transcriptional products....Full Text Available

International Nuclear Information System (INIS)

Several recent experiments on micro- (or nano-) structured samples of ferromagnetic materials are introduced. Magnetization reversal phenomena are investigated on submicron wire samples of trilayer structure using the giant magnetoresistance effect. Domain wall movements are sensitively monitored by resistivity measurements and the velocity of propagation is determined. The contribution of domain wall to the resistivity is argued from the results on artificially designed samples of a spring-magnet system. In circular dots of permalloy, the existence of vortex magnetization is confirmed and the reversal of the vortex core magnetization is studied from magnetic force microscopy measurements. (author)

UK PubMed Central (United Kingdom)

Tropomyosin (Tm) is a conserved dimeric coiled-coil protein, which forms polymers that curl around actin filaments in order to regulate actomyosin function. Acetylation of the Tm N-terminal...Full Text Available

UK PubMed Central (United Kingdom)

Two bacteriolytic enzymes secreted by Achromobacter lyticus M497-1 were purified and identified as being very similar (considering their amino acid composition and N-terminal sequence) to alpha- and...Full Text Available

International Nuclear Information System (INIS)

Nop25 is a putative RNA binding nucleolar protein associated with rRNA transcription. The present study was undertaken to determine the mechanism of Nop25 localization in the nucleolus. Deletion experiments of Nop25 amino acid sequence showed Nop25 to contain a nuclear targeting sequence in the N-terminal and a nucleolar targeting sequence in the C-terminal. By expressing derivative peptides from the C-terminal as GFP-fusion proteins in the cells, a lysine and arginine residue-enriched peptide (KRKHPRRAQDSTKKPPSATRTSKTQRRRR) allowed a GFP-fusion protein to be transported and fully retained in the nucleolus. When the peptide was fused with cMyc epitope and expressed in the cells, a cMyc epitope was then detected in the nucleolus. Nop25 did not localize in the nucleolus by deletion of the peptide from Nop25. Furthermore, deletion of a subdomain (KRKHPRRAQ) in the peptide or amino acid substitution of lysine and arginine residues in the subdomain resulted in the loss ...

UK PubMed Central (United Kingdom)

Hepatitis C virus NS3-4A is a membrane-bound enzyme complex that exhibits serine protease, RNA helicase, and RNA-stimulated ATPase activities. This enzyme complex is essential for viral genome replication...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Building complex knowledge based applications requires encoding large amounts of domain knowledge. After acquiring knowledge from domain experts, much of the effort in building a knowledge base goes into verifying that the knowledge is encoded correctly. We consider the problem of verifying hybrid knowledge bases that contain both Horn rules and a terminology in a description logic. Our approach to the verification problem is based on showing a close relationship to the problem of query containment. Our first contribution, based on this relationship, is presenting a thorough analysis of the decidability and complexity of the verification problem, for knowledge bases containing recursive rules and the interpreted predicates =, {le}, < and {ne}. Second, we show that important new classes of constraints on correct inputs and outputs can be expressed in a hybrid setting, in which a description logic class hierarchy is also ...

Science.gov (United States)

... CYBERSPACE DOMAIN: A ... 4. TITLE AND SUBTITLE Cyberspace Domain: A Warfighting Substantiated Operational Environment Imperative 5a. ...

Science.gov (United States)

We present a high-statistics calculation of nucleon electromagnetic form factors in N{sub f}=2+1 lattice QCD using domain wall quarks on fine lattices, to attain a new level of precision in systematic and statistical errors. Our calculations use 32{sup 3}x64 lattices with lattice spacing a=0.084 fm for pion masses of 297, 355, and 403 MeV, and we perform an overdetermined analysis using on the order of 3600 to 7000 measurements to calculate nucleon electric and magnetic form factors up to Q{sup 2{approx_equal}}1.05 GeV{sup 2}. Results are shown to be consistent with those obtained using valence domain wall quarks with improved staggered sea quarks, and using coarse domain wall lattices. We determine the isovector Dirac radius r{sub 1}{sup v}, Pauli radius r{sub 2}{sup v} and anomalous magnetic moment {kappa}{sub v}. We also determine connected contributions to the corresponding isoscalar observables. We ...

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Arrays of CdS:Mn{sup 2+}:Cu{sup +} micro- and nanowires grown in polycarbonate ion-track templates exhibit photoluminescence in the spectral domain ranging from 500 to 800 nm at room temperature. A comparison with similar CdS and CdS:Mn{sup 2+} wire arrays is presented. The individual contributions to the emission spectra of Cu{sup +} and Mn{sup 2+} ions in the CdS matrix are explained using their energy level schemes. Also SEM, EDX and EPR data are given for these wires. (copyright 2005 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

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Eukaryotic genomes encode a zinc finger protein (ZPR1) with tandem ZPR1 domains. In response to growth stimuli, ZPR1 assembles into complexes with eukaryotic translation elongation factor 1A (eEF1A) and the survival motor neurons protein. To gain insight into the structural mechanisms underlying the essential function of ZPR1 in diverse organisms, we determined the crystal structure of a ZPR1 domain tandem and characterized the interaction with eEF1A. The ZPR1 domain consists of an elongation initiation factor 2-like zinc finger and a double-stranded {beta} helix with a helical hairpin insertion. ZPR1 binds preferentially to GDP-bound eEF1A but does not directly influence the kinetics of nucleotide exchange or GTP hydrolysis. However, ZPR1 efficiently displaces the exchange factor eEF1B from preformed nucleotide-free complexes, suggesting that it may function as a negative regulator of eEF1A activation. Structure-based ...

UK PubMed Central (United Kingdom)

BackgroundProteins may evolve through the recruitment and modification of discrete domains, and in many cases, protein action can be dissected at the domain level. PDZ domains are...Full Text Available

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The generation of available potential energy (APE) in the space-time domain in January and July in a present-day climate simulation with a general circulation model (GCM) is compared with observations. An attempt is made to explain the differences. The generation is computed from the fields of diabatic heating and temperature. The heating is computed with the residual method, using UKMO (United Kingdom Meteorological Office) Unified Model GCM circulation data and ECMWF (European Centre for Medium-Range Weather Forecasts) initialized analyses for the period 1989-1992. The global value of the generation of APE is about 35% larger in the GCM climate than the value computed from the analyses. This is mainly because the generation of transient eddy APE in the GCM is too large, due to the more than 40% too large generation of transient eddy kinetic energy by baroclinic processes. In most of the extratropics the local contribution to the generation of ...

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Cooperation for low carbon and energy efficient development is a high priority for France, in line with the United Nations Framework Convention on Climate Change. France contributes to tackling climate change by working with its partners on all continents to implement projects both to mitigate greenhouse gas emissions and to adapt to climate change. Within the framework of the Marrakech Accords, France also encourages the implementation of the Kyoto Protocol Clean Development Mechanism, in particular between French business and non-Annex I countries; this mechanism will facilitate the financing of mitigation projects and contribute to the sustainable development of host countries in the South. At multilateral level, France is a major donor. At a bilateral level, an initial analysis of cooperation projects which are strongly linked to tackling climate change identified public support of 136 millions euros per year, as an average over the past ...

British Library Electronic Table of Contents (United Kingdom)

To test the hypothesis that transduction of the channelrhodopsin-2 (ChR2) gene, a microbial-type rhodopsin gene, into retinal ganglion cells of genetically blind rats will restore functional vision, we recorded visually evoked potentials and tested the experimental rats for the presence of optomotor responses. The N-terminal fragment of the ChR2 gene was fused to the fluorescent protein Venus and inserted into an adeno-associated virus to make AAV2-ChR2V. AAV2-ChR2V was injected intravitreally into the eyes of 6-month-old dystrophic RCS (rdy/rdy) rats. Visual function was evaluated six weeks after the injection by recording visually evoked potentials (VEPs) and testing optomotor responses. The expression of ChR2V in the retina was investigated histologically. We found that VEPs could not b...

UK PubMed Central (United Kingdom)

Forum domains are stretches of chromosomal DNA that are excised from eukaryotic chromosomes during their spontaneous non-random fragmentation. Most forum domains are 50–200 kb in length....Full Text Available

UK PubMed Central (United Kingdom)

The present article examines the nature of and relations among the domains of behavior analysis. It first proposes a set of annotated, descriptive criteria to aid in distinguishing the experimental...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The traditional process for developing large-scale simulations is cumbersome, time consuming, costly, and in some cases, inadequate. The topics of software components and component-based software engineering are being explored by software professionals in academic and industrial settings. A component is a well-delineated, relatively independent, and replaceable part of a software system that performs a specific function. Many researchers have addressed the potential to derive a component-based approach to simulations in general, and a few have focused on military simulations in particular. In a component-based approach, functional or logical blocks of the simulation entities are represented as coherent collections of components satisfying explicitly defined interface requirements. A simulation is a top-level aggregate comprised of a collection of components that interact with each other in the context of a simulated environment. A component may represent a simulation artifact, an ...

International Nuclear Information System (INIS)

Focused Ion Beam (FIB) milling is a powerful tool to produce ordered magnetic nanostructures. However, it is impossible to produce out-of-plane magnetized nanoscale structures from multilayer films by direct FIB writing. Co/Pt multilayers exhibit an out-of-plane easy axis due to strong perpendicular interface anisotropy. The interface contribution is known to be very sensitive to high energy ion irradiation. In case of 30 keV Ga ions it needs less than one ion per 100 surface atoms to destroy the perpendicular interface anisotropy. We demonstrate how this problem can be overcome by milling a Co/Pt multilayer, which has been deposited on a SiN membrane, from the rear side, through the SiN. The effect of the ions is determined as a function of applied dose utilizing the domain structure imaged by soft X-ray holography. When the magnetic material is removed we find only a very narrow range of destruction around the holes in contrast to the ...

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CERN Document Server

In this paper we dealt with the comparison and linking between lexical resources with domain knowledge provided by ontologies. It is one of the issues for the combination of the Semantic Web Ontologies and Text Mining. We investigated the relations between the linguistics oriented and domain-specific semantics, by associating the GO biological process concepts to the FrameNet semantic frames. The result shows the gaps between the linguistics-oriented and domain-specific semantics on the classification of events and the grouping of target words. The result provides valuable information for the improvement of domain ontologies supporting for text mining systems. And also, it will result in benefits to language understanding technology.

British Library Electronic Table of Contents (United Kingdom)

Four extracellular keratinases (designated KI, KII, KIII, and KIV) were produced during submerged aerobic cultivation in a medium containing native human foot skin (NHFS) for enzyme synthesis. The molecular weights, determined by SDS-PAGE, were 25, 50, 34, and 19kDa, respectively. Gel filtration of the four purified enzymes in native conditions indicated that active keratinase KI is a novel homo-octamer, KII a homo-dimer, and KIII and KIV monomers. All four keratinases exhibited high activities at pH 8.0-10.0 with an optimal pH of 9.0. The optimal temperature for keratinolytic activity of KI, KII, and KIII was approximately 50, and 60degreeC for KIV. One millimolar of PMSF completely inhibited the keratinolytic activities of the four enzymes. The N-terminal sequences of KI, KII, and KIII s...

UK PubMed Central (United Kingdom)

Peripheral subunit binding domains (PSBDs) are integral parts of large multienzyme complexes involved in carbohydrate metabolism. PSBDs facilitate shuttling of prosthetic groups between different catalytic...Full Text Available

Science.gov (United States)

Several central results of the method of structural formulae for some classes of analytic functions, which were known before for a disc and an annulus, are generalized to analytic functions in a finitely connected circular domain.

UK PubMed Central (United Kingdom)

BackgroundEukaryotic DNA replication is regulated at the level of large chromosomal domains (0.5–5 megabases in mammals) within which replicons are activated relatively synchronously....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundZhx1 to 3 (zinc-fingers and homeoboxes) form a set of paralogous genes encoding multi-domain proteins. ZHX proteins consist of two zinc fingers followed...Full Text Available

Science.gov (United States)

In this paper, the authors first describe a fourth order accurate finite difference discretization for both the Laplace equation and the heat equation with Dirichlet boundary conditions on irregular domains. In the case of the heat equation, they use an i...

UK PubMed Central (United Kingdom)

BackgroundSteroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind....Full Text Available

UK PubMed Central (United Kingdom)

The 3-D spectral-domain optical coherence tomography (SD-OCT) images of the retina often do not reflect the true shape of the retina and are distorted differently along the x and y...Full Text Available

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... Verheij (1980) described how the frequency domain could be exploited using cross spectral density measurements to measure the flexural ...

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No abstract prepared.

UK PubMed Central (United Kingdom)

The YTH (YT521-B homology) domain was identified by sequence comparison and is found in 174 different proteins expressed in eukaryotes. It is characterized by 14 invariant residues within an α-helix/β-sheet...Full Text Available

Science.gov (United States)

There are about fifty SET domain protein methyltransferases (PMTs) in the human genome, that transfer a methyl group from S-adenosyl-L-methionine (SAM) to substrate lysines on histone tails or other peptides. A number of structures in complex with cofactor, substrate, or inhibitors revealed the mechanisms of substrate recognition, methylation state specificity, and chemical inhibition. Based on these structures, we review the structural chemistry of SET domain PMTs, and propose general concepts towards the development of selective inhibitors.

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This study focuses the granitoids of center-southern portion of Guyana Shield, southeastern Roraima, Brazil. The region is characterized by two tectonic-stratigraphic domains, named as Central Guyana (GCD) and Uatuma-Anaua (UAD) and located probably in the limits of geochronological provinces (e.g. Ventuari-Tapajos or Tapajos-Parima, Central Amazonian and Maroni-Itacaiunas or Transamazon). The aim this doctoral thesis is to provide new petrological and lithostratigraphic constraints on the granitoid rocks and contribute to a better understanding of the origin and geo dynamic evolution of Guyana Shield. The GCD is only locally studied near to the UAD boundary, and new geological data and two single zircon Pb-evaporation ages in mylonitic biotite granodiorite (1.89 Ga) and foliated hastingsite-biotite granite (1.72 Ga) are presented. These ages of the protholiths contrast with the lithostratigraphic picture in the other areas of Cd (1.96-1.93 ...

Energy Technology Data Exchange (ETDEWEB)

The magnetic structure of the cubic compound CeAl{sub 2} is incommensurate and double-k. The moments on the two Ce sites describe two elliptical helices of opposed chiralities and lie in the (11-bar0) plane, with their Fourier components m{sup k} close to the [111] direction. Recent symmetry considerations, including for the first time the inversion center of the crystal, have reduced the number of parameters of this structure and have underlined the existence of a phase difference between the projections m{sub x}{sup k}, m{sub y}{sup k} and m{sub z}{sup k} of m{sup k}. Up to now, although many neutron investigations have been carried out on CeAl{sub 2} single crystals, no set of magnetic intensities was available which was large and good enough to check whether this phase difference exists or not. We have measured such a set of data, taking great care of the instrumental resolution in order to avoid unwanted contributions to the intensities from other ...

Energy Technology Data Exchange (ETDEWEB)

The increasing complexity of the real-time data acquisition and processing systems (TDAQ: the so called Trigger and Data AcQuisition systems) in high energy physics calls for an appropriate evolution of development tools. This work is about the interplay between in principle specifications of TDAQ systems and their actual design and realization on a concrete hardware and software platform. The basis of our work is to define a methodology for the development of TDAQ systems that meets the specific demands for the development of such systems. The result is the detailed specification of a 'methodological framework' based on the Unified Modeling Language (UML) and designed to manage a development process. The use of this UML-based methodological framework progressively leads to the setting up of a 'home-made' framework, i.e. a development tool that comprises reusable components and generic architectural elements adapted to TDAQ systems. The main parts of ...

Energy Technology Data Exchange (ETDEWEB)

Canada's oil sands contain the largest known reserve of oil in the world. Oil sands mining uses 3 functional processes, ore hauling, overburden removal and mechanical maintenance. The industry relies mainly on truck-and-shovel technology in its open-pit mining operations which contributes greatly to the overall mining operation cost. Coordination between operating units is crucial for achieving an enterprise-wide optimal operation level. Some of the challenges facing the industry include multiple or conflicting objectives such as minimizing the use of raw materials and energy while maximizing production. The large sets of constraints that define the feasible domain pose as challenge, as does the uncertainty in system parameters. One solution lies in assigning truck resources to various activities. This fully decentralized approach would treat the optimization of ore production, waste removal and equipment maintenance independently. It ...

Science.gov (United States)

Eight phospholipases A2 (PLAs) and four three-finger-toxins (3FTx) from the pooled venom of Bungarus fasciatus (Bf) were previously studied and sequenced, but their expression pattern in individual Bf venom and possible geographic variations remained to be investigated. We herein analyze the individual venom of two Bf specimens from Kolkata (designated as KBf) to address this question. Seven PLAs and five 3FTx were purified from the KBf venoms, and respective cDNAs were cloned from venom glands of one of the snakes. Comparison of their mass and N-terminal sequence revealed that all the PLAs were conserved in both KBf venoms, but that two of their 3FTx isoforms were variable. When comparing the sequences of these KBf-PLAs with those published, only one was found to be identical to that of Bf Vb-2, and the other five were 94-98% identical to those of Bf II, III, Va, VI and XI-2, respectively. Notably, the most abundant PLA isoforms of Bf and KBf venoms contain Pro31 ...

Science.gov (United States)

From the dried fruiting bodies of the mushroom Armillaria luteo-virens, a dimeric lectin with a molecular mass of 29.4 kDa has been isolated. The purification procedure involved (NH{sub 4}){sub 2}SO{sub 4} precipitation, ion exchange chromatography on DEAE-cellulose, CM-cellulose, and Q-Sepharose, and gel filtration by fast protein liquid chromatography on Superdex 75. The hemagglutinating activity of the lectin could not be inhibited by simple sugars but was inhibited by the polysaccharide inulin. The activity was stable up to 70 {sup o}C but was acid- and alkali-labile. Salts including FeCl{sub 3}, AlCl{sub 3}, and ZnCl{sub 2} inhibited the activity whereas MgCl{sub 2}, MnCl{sub 2}, and CaCl{sub 2} did not. The lectin stimulated mitogenic response of mouse splenocytes with the maximal response achieved by 1 {mu}M lectin. Proliferation of tumor cells including MBL2 cells, HeLa cells, and L1210 cells was inhibited by the lectin with an IC{sub 5} of 2.5, 5, and 10 {mu}M, respectively. ...

Energy Technology Data Exchange (ETDEWEB)

Step-scan Fourier transform infrared spectroscopy in conjunction with impulse stress on polymer films has been used to monitor dynamic rheological responses in real time. A novel piezo-electrically-driven polymer microrheometer was employed to apply repetitive impulses to the polymer sample while time-domain spectra were recorded. Recent results include the study of both semi-crystalline polymers such as isotactic polypropylene (iPP) and elastomers such as Estane polyester/polyurethane copolymer and Kraton tri-block copolymer. The spectral changes of iPP are consistent with frequency-domain results. For iPP at room temperature, large differences in the response times of different absorption bands are not seen. However, the orientation response of the CH{sub 3} rocking mode is slightly slower than the responses of the backbone modes. To the authors` knowledge, this is the first reported successful step-scan FTIR time-domain ...

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A wavelet transformation is performed over each of the spatial coordinates of the scalar wave equation. This transformed equation is solved directly with a finite-difference scheme for both homogeneous and smooth inhomogeneous media. Wavefield extrapolation is performed completely in the spatial wavelet domain without transforming back into the space domain at each time step. The wavelet coefficients are extrapolated, rather than the wavefield itself. The numerical solution of the scalar wave equation in the spatial wavelet domain is closely related to the finite-difference method because of the compact support of the wavelet bases. Poststack reverse-time migration is implemented as an application. The resolution spaces of the wavelet transform provide a natural framework for multigrid analysis. Migrated images are constructed from various resolution spaces.

UK PubMed Central (United Kingdom)

Telomeres protect the chromosome ends from unscheduled DNA repair and degradation. Telomeres are heterochromatic domains composed of repetitive DNA (TTAGGG repeats) bound to an array of specialized...Full Text Available

International Nuclear Information System (INIS)

In this paper, a time-domain equivalent circuit method is applied to solve dispersion of coupled-cavity travelling-wave tube (CCTWT). First, the time-domain circuit equations of CCTWT coupled-cavity chain are deduced from the equivalent circuit model. Then, the equations are solved numerically by fourth-order Runge-Kutta method and a program CTTDCP is developed using MATLAB. Last, a L-band CCTWT is calculated using CTTDCP and the cavity pass-band of this tube is computed to be 1.08-1.48 GHz, which is consistent with the experimental results and the simulation results of electromagnetic code and demonstrates the validity of the time-domain equivalent circuit method. In addition, a new design method which uses the equivalent circuit method and electromagnetic simulation together to optimize the cold cavity characteristics of CCTWT is proposed. (authors)

Science.gov (United States)

... where i is the wavelength index (ranging from 1 to 4), while Esb and FHb02 are the molar extinction coefficients of deoxy-hemoglobin and oxy ...

International Nuclear Information System (INIS)

This report documents the research activities by Rogers and Associates Engineering Corporation on grant DE-FG03-93ER61600 during the funded project period from August 1993 to April 1996. The objective of this research was to characterize the mechanisms and rates of radon gas penetration of the different structural domains of the concrete components of residential floor slabs, walls, and associated joints and penetrations. The research was also to characterize the physical properties of the concretes in these domains to relate their radon resistance to their physical properties. These objectives support the broader goal of characterizing which, if any, concrete domains and associated properties constitute robust barriers to radon and which permit radon entry, either inherently or in ways that could be remediated or avoided.

UK PubMed Central (United Kingdom)

SummaryWe consider the problem of estimating the effect of exposure on multiple continuous outcomes, when the outcomes are measured on different scales and are nested within multiple...Full Text Available

Science.gov (United States)

and shock induced flow separation may significantly affect the flutter ...... Aerodynamic and Aeroelastic Simulation, AGARD Report 822, 10-1 10-20. ...

British Library Electronic Table of Contents (United Kingdom)

A boundary value problem for Laplace?s equation in a bounded two-dimensional domain filled with a piecewise homogeneous medium is considered. The boundary of the inhomogeneity is assumed to be unknown. The inverse problem of determining the inhomogeneity boundary and the solution of the equation given the solution and its normal derivative on the boundary of the domain is discussed. Numerical methods are proposed for solving the inverse problem, and the results of numerical experiments are presented.

International Nuclear Information System (INIS)

The structural changes attendant on intermartensitic transformation in a Ni-Mg-Ga shape memory alloy are considered using magneto-optical visualization with the help of ferrite-garnet monocrystalline films. It is established that on the intermartensitic transformation the complete reorganization of martensite macrostructure fails. Martensite crystals resulted from the basic transformation change somewhat their sizes on intermartensitic transition. The existence of large-scale labyrinth magnetic domain structure is revealed

British Library Electronic Table of Contents (United Kingdom)

Four solutions of the Cauchy problem for Mathieu?s equation away from parametric resonance domains are analytically constructed using an asymptotic averaging method in the fourth approximation. Three solutions occur near fractional parameter values at which slow combination phases exist. The fourth solution occurs in the absence of slow phases away from parametric resonance domains and the fractional parameter values.

Energy Technology Data Exchange (ETDEWEB)

The report contains an overall frame for transformation of knowledge and experience from risk analysis to emergency education. An accident model has been developed to describe the emergency situation. A key concept of this model is uncontrolled flow of energy (UFOE), essential elements are the state, location and movement of the energy (and mass). A UFOE can be considered as the driving force of an accident, e.g., an explosion, a fire, a release of heavy gases. As long as the energy is confined, i.e. the location and movement of the energy are under control, the situation is safe, but loss of confinement will create a hazardous situation that may develop into an accident. A domain model has been developed for representing accident and emergency scenarios occurring in society. The domain model uses three main categories: status, context and objectives. A domain is a group of activities with allied goals and elements and ten ...

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This CD-ROM contains 34 contributions which were held on the 36th MPA seminar 2010 in Stuttgart (Germany). 32 contributions are separately analyzed for the ETDE database.

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

International Nuclear Information System (INIS)

... odd nuclei organic compounds radiation effects radioisotopes synthesis

International Nuclear Information System (INIS)

... compounds plants radiation effects radioisotopes reaction kinetics trees

British Library Electronic Table of Contents (United Kingdom)

Background: Although research on epistemological beliefs has expanded over the past two decades, there are still some issues that need to be explored, such as whether epistemological beliefs are domain general or domain specific. Purpose: One of the purposes of this research was to determine if high school students' general epistemological beliefs were different from their epistemological beliefs in the domain of physics. Sample: The research was conducted with 15 grade nine students studying in an urban all-boys school. Their average age was 16. Their previous school experiences were traditional oriented. Design and methods: A case study design with qualitative methods was used for the research. Two questionnaires were developed and used in semi-structured interview protocols two times, w...

Energy Technology Data Exchange (ETDEWEB)

This paper describes the Knowledge Encapsulation Framework (KEF), a suite of tools to enable knowledge inputs (relevant, domain-specific facts) to modeling and simulation projects, as well as other domains that require effective collaborative workspaces for knowledge-based task. This framework can be used to capture evidence (e.g., trusted material such as journal articles and government reports), discover new evidence (covering both trusted and social media), enable discussions surrounding domain-specific topics and provide automatically generated semantic annotations for improved corpus investigation. The current KEF implementation is presented within a wiki environment, providing a simple but powerful collaborative space for team members to review, annotate, discuss and align evidence with their modeling frameworks. The novelty in this approach lies in the combination of automatically tagged and user-vetted resources, ...

British Library Electronic Table of Contents (United Kingdom)

A nonlinear free boundary-value problem of supercavitating flow past n + 1 hydrofoils is analyzed. To describe the cavities' closure mechanism, the Tulin-Terentev single-spiral-vortex model is employed. The flow domain is considered as the image of an (n + 1)-connected circular domain. The conformal map is constructed in terms of the solutions to two Riemann-Hilbert problems of the theory of symmetric automorphic functions. One of the problems is homogeneous and its coefficients are continuous functions while the second problem is inhomogeneous and has discontinuous coefficients. The exact solutions to the problems are found by using quasiautomorphic and quasimultiplicative analogs of the Cauchy kernel. The case of a single plate is considered in detail and the numerical results are report...

British Library Electronic Table of Contents (United Kingdom)

Identifying gear damage categories, especially for early faults and combined faults, is a challenging task in gear fault diagnosis. This paper proposes a new multidimensional hybrid intelligent diagnosis method to identify different categories and levels of gear damage automatically. In this method, Hilbert transform, wavelet packet transform (WPT) and empirical mode decomposition (EMD) are performed on gear vibration signals to extract additional fault characteristic information. Then, multidimensional feature sets including time-domain, frequency-domain and time-frequency-domain features are generated to reveal gear health conditions. Multiple classifiers based on several classification algorithms and input features are combined with genetic algorithm (GA). Because of the use of multidim...

UK PubMed Central (United Kingdom)

Effector proteins expressed in the esophageal gland cells of cyst nematodes are delivered into plant cells through a hollow, protrusible stylet. Although evidence indicates that effector proteins function...Full Text Available

UK PubMed Central (United Kingdom)

Cytosine methylation in DNA is a major epigenetic signal, and plays a central role in propagating chromatin status during cell division. However the mechanistic links between DNA methylation...Full Text Available

UK PubMed Central (United Kingdom)

SUMMARYIn voltage-gated sodium, potassium, and calcium channels the functions of ion conduction and voltage sensing are performed by two distinct structural units: the pore domain...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundChromatin insulators or boundary elements are a class of functional elements in the eukaryotic genome. They regulate gene transcription by interfering with promoter-enhancer...Full Text Available

UK PubMed Central (United Kingdom)

In the American educational system, school transitions are frequent and predictable, but they can disrupt student functioning across developmental domains. How students experience school transitions...Full Text Available

UK PubMed Central (United Kingdom)

SummaryThe Hippo tumor-suppressor pathway controls tissue growth in Drosophila and mammals by regulating cell proliferation and apoptosis. The Hippo pathway includes...Full Text Available

UK PubMed Central (United Kingdom)

Peptide toxins with high affinity, divergent pharmacological functions, and isoform-specific selectivity are powerful tools for investigating the structure-function relationships of voltage-gated...Full Text Available

UK PubMed Central (United Kingdom)

Recognition of acetylated chromatin by the bromodomains and extra-terminal domain (BET) family proteins is a hallmark for transcriptional activation and anchoring viral genomes to mitotic chromosomes...Full Text Available

UK PubMed Central (United Kingdom)

This review presents a summary of existing knowledge regarding the impact of testicular cancer along four broad domains, including romantic and sexual relationships, body image, and fertility....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Specificity of the pulses mean frequency measurement (the pulses being generated in a stochastic process) is described. Status of the domain of analog frequency meters is presented. Methods of increasing accuracy of such meters are discussed.

UK PubMed Central (United Kingdom)

The Aer protein in Escherichia coli is a membrane-bound, FAD-containing aerotaxis and energy sensor that putatively monitors the redox state of the electron transport system. Binding...Full Text Available

UK PubMed Central (United Kingdom)

Noncoding RNAs play important roles in various aspects of gene regulation. We have identified 7SK RNA to be enriched in nuclear speckles or interchromatin granule clusters (IGCs), a subnuclear domain...Full Text Available

UK PubMed Central (United Kingdom)

Centrioles are intriguing cylindrical organelles composed of triplet microtubules. Proteomic data suggest that a large number of proteins besides tubulin are necessary for the formation and maintenance...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Limitations of traveling wave relaying schemes for protection of overhead extra-high voltage transmission lines are investigated. A method of analysis of traveling wave phenomena for three phase transmission lines is developed in which the interdependent phase voltages and currents are decoupled into their modal counterparts, which are approximately independent. A time domain digital simulation program is used to solve the modal transmission line equations to obtain the fault induced traveling waves detected at the relay location. The frequency dependence of the aerial modes is ignored but their losses are included. A lumped element analysis method, originally developed for transient analysis of lossy coaxial cables, is adapted here to obtain approximate solution for the fault induced traveling waves of the ground mode. Excellent agreement is found between the results obtained by this method and frequency domain methods. This ...

UK PubMed Central (United Kingdom)

In the somatosensory domain it is still unclear at which processing stage information reaches the opposite hemispheres. Due to dense transcallosal connections, the secondary somatosensory cortex (S2)...Full Text Available

UK PubMed Central (United Kingdom)

Mitochondria must uptake some phospholipids from the endoplasmic reticulum (ER) for the biogenesis of their membranes. They convert one of these lipids, phosphatidylserine, to phosphatidylethanolamine,...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundNew technology allows more precise definition of structural alterations of all retinal layers although it has not been used previously in cases of optic...Full Text Available

UK PubMed Central (United Kingdom)

The Japanese medaka fish Oryzias latipes has an XX/XY sex-determination system. The Y-linked sex-determination gene DMY is a duplicate of the autosomal gene DMRT1, which encodes a DM-domain-containing...Full Text Available

UK PubMed Central (United Kingdom)

Magnetotactic bacteria contain chains of magnetically interacting crystals (magnetosome crystals), which they use for navigation (magnetotaxis). To improve magnetotaxis efficiency, the magnetosome crystals...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo establish normative values for macular light sensitivity and to determine the intrasession fluctuation of perimetric responses using the OPKO/OTI microperimeter.Full Text Available

UK PubMed Central (United Kingdom)

Amyloid precursor protein (APP), implicated in Alzheimer's disease, is a transmembrane protein of undetermined function. APP is cleaved by gamma-secretase that releases the APP intracellular domain...Full Text Available

UK PubMed Central (United Kingdom)

Over the last century, anatomical studies have shown that the cerebral cortex can be subdivided into structurally distinct regions, giving rise to a new branch of neuroanatomy: ‘architectonics’....Full Text Available

UK PubMed Central (United Kingdom)

Pestiviruses are positive-strand RNA viruses closely related to human hepatitis C virus. Gene expression of these viruses occurs via translation of a polyprotein, which is further processed by cellular...Full Text Available

CERN Document Server

Motivated by the numerical investigations of Laval, Dubrulle & Nazarenko (1999), we develop a quasilinear theory of the 2D Euler equation and derive an integro-differential equation for the evolution of the coarse-grained vorticity. This equation respects all the invariance properties of the Euler equation and conserves angular momentum in a circular domain and linear impulse in a channel (as well as in an infinite domain). The explicit energy is not rigorously conserved as it is partly transfered into fine-grained fluctuations but the total energy is conserved. We prove a H-theorem for the Fermi-Dirac entropy and make the connection with statistical theories of 2D turbulence.

Energy Technology Data Exchange (ETDEWEB)

Yucca Mountain, Nevada is a potential site for a high-level radioactive-waste repository. Uncertainty and sensitivity analyses were performed to estimate critical factors in the performance of the site with respect to a criterion in terms of pre-waste-emplacement ground-water travel time. The degree of failure in the analytical model to meet the criterion is sensitive to the estimate of fracture porosity in the upper welded unit of the problem domain. Fracture porosity is derived from a number of more fundamental measurements including fracture frequency, fracture orientation, and the moisture-retention characteristic inferred for the fracture domain.

DEFF Research Database (Denmark)

Nonlinear distortion added by the loudspeaker in a hearing aid lowers the signal-to-noise ratio and may degrade the hearing aid user's ability to understand speech. The balancedarmature- type loudspeakers, predominantly used in hearing aids, are inherently nonlinear devices, as any displacement of the loudspeaker diaphragm inevitably changes the magnetic and electrical characteristics of the loudspeaker. A numerical time-domain model capable of describing these nonlinearities is presented. By simulation it is demonstrated how the output distortion could potentially be reduced significantly through careful design of the mechanical properties of the armature.

Energy Technology Data Exchange (ETDEWEB)

The fuzzy polar power system stabilizer (FPPSS) which has been recently developed is analyzed using frequency domain methods. the frequency domain approach allows the PSS designer to compare the new FPPSS with more conventional controllers. The significance of the three FPPSS design parameters are readily seen from the frequency response data, and their relationship to the conventional lead-lag design approach can be evaluated. Furthermore, the frequency response data for the FPPSS allows an alternate design approach for this stabilizer, and can be used to develop information concerning the small signal stability of the resulting system.

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Dynamic contingency analysis is certainly a demanding task in the context of dynamic performance evaluation. This paper presents the results of a test for checking the contingency screening capability of the IPEBS method. A brazilian 1100-bus, 112-gen system was used in the test; the ranking of the contingencies based on critical clearing times obtained with IPEBS, was compared with the ranking derived from detailed time-domain simulation. The results of this comparison encourages us to recommended the use of the method in industry applications, in a complementary basis to the current method of time domain simulation. (author) 5 refs., 1 fig., 2 tabs.

Energy Technology Data Exchange (ETDEWEB)

This paper reports that grinding and polishing affected the orientation of 90[degrees] domains at the surface of lead zirconate titanate (PZT) ceramics. This was quantified by using changes in the intensity ratio of the (002) and (200) X-ray reflections. Grinding unpoled PZT with 600-grit SiC paper gave X-ray intensity ratios similar to those of poled material. This implies that 90[degrees] domain realignments had occurred in the near surface region probed by the X-rays. Grinding poled samples with 600-grit SiC further increased the X-ray intensity ratio beyond that caused by poling, indicating that additional surface reorientation of 90[degrees] domains had occurred. The effects of diamond polishing depended on the size of the diamond particles. The use of 6-[mu]m diamond had no effect on the (002)/(200) intensity ratio of either poled or unpoled samples, while polishing with 15- or 45-[mu]m diamond significantly enhanced ...

International Nuclear Information System (INIS)

At the quark level there are basically two types of contributions of R-parity violating supersymmetry (Rep SUSY) to neutrinoless double beta decay: the short-range contribution involving only heavy virtual superpartners and the long-range one with the virtual squark and neutrino. Hadronization of the effective operators, corresponding to these two types of contributions, may in general involve virtual pions in addition to close on-mass-shell nucleons. From the previous studies it is known that the short-range contribution is dominated by the pion exchange. In the present paper we show that this is also true for the long-range Rep SUSY contribution. Therefore, we conclude that the Rep SUSY contributes to the neutrinoless double beta decay dominantly via charged pion exchange between the decaying nucleons.

Science.gov (United States)

This study investigates the contributions of the military working dogs in Vietnam to determine their significance to the United States' war effort. There is limited written history concerning the use of the military working dogs in Vietnam. The methods an...

Science.gov (United States)

... High water temper- atures from June through October also contributed to the observed high catch probabilities in 1995. ...

CERN Document Server

Recent nucleosynthesis calculations of Type II supernovae using advanced neutrino transport determine that the early neutrino winds are proton-rich. However, a fraction of the ejecta emitted at the same time is composed of neutron-rich pockets. In this paper we calculate the nucleosynthesis contribution from the neutron-rich pockets in the hot convective bubbles of a core-collapse supernova and show that they do not contribute significantly to the total nucleosynthesis.

International Nuclear Information System (INIS)

Scanning ion microscopy with polarization analysis (SIMPA) is used to study the spin-resolved surface magnetic structure of nano-sized magnetic systems. SIMPA is utilized for in situ topographic and spin-resolved magnetic domain imaging as well as for focused ion beam (FIB) etching of desired structures in magnetic or non-magnetic systems. Ultra-thin Co films are deposited on surfaces of Si(1 0 0) substrates, and ultra-thin, tri-layered, bct Fe(1 0 0)/Mn/bct Fe(1 0 0) wedged magnetic structures are deposited on fcc Pd(1 0 0) substrates. SIMPA experiments clearly show that ion-induced electrons emitted from magnetic surfaces exhibit non-zero electron spin polarization (ESP), whereas electrons emitted from non-magnetic surfaces such as Si and Pd exhibit zero ESP, which can be used to calibrate sputtering rates in situ. We report on new, spin-resolved magnetic microstructures, such as magnetic 'C' states and magnetic vortices, found at surfaces of FIB patterned ...

CERN Document Server

Data Mining deals extracting hidden knowledge, unexpected pattern and new rules from large database. Various customized data mining tools have been developed for domain specific applications such as Biomedicine, DNA analysis and telecommunication. Trends in data mining include further efforts towards the exploration of new application areas and methods for handling complex data types, algorithm scalability, constraint based data mining and visualization methods. In this paper we will present domain specific Secure Multiparty computation technique and applications. Data mining has matured as a field of basic and applied research in computer science in general. In this paper, we survey some of the recent approaches and architectures where data mining has been applied in the fields of e-payment systems. In this paper we limit our discussion to data mining in the context of e-payment systems. We also mention a few directions for further work in ...

Energy Technology Data Exchange (ETDEWEB)

Magnetic imaging in the transmission electron microscope (TEM) has been used to examine submicron elements with the aim of discovering down to what element size complex domain patterns can form. The elements were squares, circles, triangles, and pentagons in the size range 100{endash}500 nm and were made from 36 nm Co films or 8 nm Ni{sub 80}Fe{sub 20} (NiFe) with in-plane magnetization. The magnetic domain structures in these elements were imaged at high resolution using the differential phase contrast imaging mode in a TEM. Nonuniform magnetization structures were seen in the images. Vortices were present at remanence in all shapes of 36-nm-thick Co elements down to 100 nm size and in circular NiFe elements down to 116 nm diameter. Triangular NiFe elements did not have a vortex state at remanence, instead the magnetization curved round within the element but did not achieve complete flux closure. In simulations of square and circular NiFe ...

CERN Document Server

A Langmuir film is a molecularly thin film on the surface of a fluid; we study the evolution of a Langmuir film with two co-existing fluid phases driven by an inter-phase line tension and damped by the viscous drag of the underlying subfluid. Experimentally, we study an 8CB Langmuir film via digitally-imaged Brewster Angle Microscopy (BAM) in a four-roll mill setup which applies a transient strain and images the response. When a compact domain is stretched by the imposed strain, it first assumes a bola shape with two tear-drop shaped reservoirs connected by a thin tether which then slowly relaxes to a circular domain which minimizes the interfacial energy of the system. We process the digital images of the experiment to extract the domain shapes. We then use one of these shapes as an initial condition for the numerical solution of a boundary-integral model of the underlying hydrodynamics and compare the subsequent images of ...

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The influences of compressive stress on the dielectric properties of (1 - x)Pb(In{sub 1/2}Nb{sub 1/2})O{sub 3}-xPbTiO{sub 3} (x = 0.1-0.5) ceramics was investigated in this study. The dielectric properties were measured under compressive stress applied parallel and perpendicular to electric field. The results clearly showed that the superimposed compression stress had pronounced effects on the dielectric properties of PIN-PT ceramics. In general, with increasing compressive stress the dielectric constant of the ceramics increased and decreased when the stress was applied parallel and perpendicular, respectively, to the electric field direction. The dielectric loss tangent, however, decreased in both stress cases. The observations were mainly interpreted in terms of competing influences of the domain switching through non-180 deg. domain walls, clamping of domain walls, de-ageing and the stress-induced decrease in the ...

British Library Electronic Table of Contents (United Kingdom)

Problems experienced during Floating Production, Storage and Offloading (FPSO) tandem offloading operations were investigated. The aim of this research was to improve the reliability of such systems, and it needed a means to assess them. Time-domain simulation and analysis of offloading systems was performed using the multi-body mooring software ARIANE 7.0. Hydrodynamic interaction between the vessels was considered. The responses of the offloading system in different loading cases, different parameters of offloading hawsers and the effects of challenging environmental conditions were calculated. There was a focus on the problems of relative motion between the two bodies and its effects on the intensity of hawser forces. Minimum relative distance, maximum relative headings and maximum tens...

Energy Technology Data Exchange (ETDEWEB)

We conducted broadband absorption measurements of atmospheric water vapor in the ground state, X {sup 1}A{sub 1} (000), from 0.4 to 2.7 THz with a pressure broadening-limited resolution of 6.2 GHz using pulsed, terahertz time-domain spectroscopy (THz-TDS). We measured a total of seventy-two absorption lines and forty-nine lines were identified as H{sub 2}{sup 16}O resonances. All the H{sub 2}{sup 16}O lines identified were confirmed by comparing their center frequencies to experimental values available in the literature.

Energy Technology Data Exchange (ETDEWEB)

This report summarizes the work done at the University of Massachusetts in the area of Image Understanding of static scene domains. The goal of this research project was to demonstrate a practical knowledge-based approach to computer vision that utilized multiple levels of parallel processing. Some problems dealt with included extracting lines, grouping together regions and lines from the same surface, computing pose from geometry, and matching corresponding features in different views. Special attention was also given to the extraction of curved lines and curved surfaces. The static scene domains consisted of both ROAD and HOUSE scenes, each containing approximately fourteen (14) different objects per scene.

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Highly ordered arrays of Ni nanoholes and Fe{sub 20}Ni{sub 80} antidots have been prepared, respectively, by replica/antireplica processing and sputtering techniques using nanoporous alumina membranes as templates. Geometrical characteristics as nanohole/antidot diameter, interpore distance and the overall hexagonal symmetry of arrays are controlled through the original templates. Experimental data on their hysteresis and magnetic domain structure have been taken by vibrating sample magnetometry and magnetic force microscopy, respectively. An analysis of the magnetization process, resulting magnetic anisotropy and magnetic domain structure is summarized considering the influence of those geometry aspects. In particular, the hexagonal symmetry and the density of nanohole/antidots determine the overall magnetic behavior, which is of interest in future high-density magnetic storage systems.

DEFF Research Database (Denmark)

Level set method based segmentation provides an efficient tool for topological and geometrical shape handling. Conventional level set surfaces are only $C^0$ continuous since the level set evolution involves linear interpolation to compute derivatives. Bajaj et al. present a higher order method to evaluate level set surfaces that are $C^2$ continuous, but are slow due to high computational burden. In this paper, we provide a higher order GPU based solver for fast and efficient segmentation of large volumetric images. We also extend the higher order method to multi-domain segmentation. Our streaming solver is efficient in memory usage.

Energy Technology Data Exchange (ETDEWEB)

The switching behavior of magnetic patterns prepared by ion irradiation was investigated. Co/Pt multilayers with perpendicular anisotropy and large out-of-plane coercivities 5-6 kOe were grown on electron transparent SiN windows. Regularly spaced 1 micron sized regions, were magnetically pattered via ion beam irradiation through a stencil mask. Lorentz TEM was used to observe in-situ magnetization reversal processes of irradiated regions under well-defined applied magnetic fields. When the in-plane field was increased, domain wall motion was observed, resulting in the alignment of the patterns with the direction of the applied field. The switching mechanism of the in-plane patterns was by domain wall motion.

CERN Document Server

We calculate the quarkonium dissociation rate in the P and CP-odd domains (bubbles) that were possibly created in heavy-ion collisions. In the presence of the magnetic field produced by the valence quarks of colliding ions, parity-odd domains generate electric field. Quarkonium dissociation is the result of quantum tunneling of quark or antiquark through the potential barrier in this electric field. The strength of the electric field in the quarkonium comoving frame depends on the quarkonium velocity with respect to the background magnetic field. We investigate momentum, electric field strength and azimuthal dependence of the dissociation rate. Azimuthal distribution of quarkonia surviving in the electromagnetic field is strongly anisotropic; the form of anisotropy depends on the relation between the electric and magnetic fields and quarkonium momentum. These features can be used to explore the properties of the electromagnetic field created in ...

CERN Document Server

Term extraction is one of the layers in the ontology development process which has the task to extract all the terms contained in the input document automatically. The purpose of this process is to generate list of terms that are relevant to the domain of the input document. In the literature there are many approaches, techniques and algorithms used for term extraction. In this paper we propose a new approach using particle swarm optimization techniques in order to improve the accuracy of term extraction results. We choose five features to represent the term score. The approach has been applied to the domain of religious document. We compare our term extraction method precision with TFIDF, Weirdness, GlossaryExtraction and TermExtractor. The experimental results show that our propose approach achieve better precision than those four algorithm.

British Library Electronic Table of Contents (United Kingdom)

PurposeTo characterize the morphology of outer retinal holes caused by solar maculopathy, using spectral-domain optical coherence tomography (SD-OCT). DesignThis study is an observational case series. MethodsThe SD-OCT findings of 3 patients (6 eyes) with chronic solar maculopathy are presented. ResultsSD-OCT demonstrates a characteristic appearance of partial-thickness hole(s) in the outer retina at the fovea. In 3 of 6 eyes, there is 1 hole directly beneath the umbo. In the remaining 3 eyes, there are multifocal holes spread across the fovea. Holes in more restricted layers, as had been previously reported with time-domain OCT, were not seen. In addition, advanced visualization of SD-OCT data demonstrates a hyperreflective ring around the outer retinal hole. ConclusionsSD-OCT can be used...

International Nuclear Information System (INIS)

The development and occurrence of new electron accelerators and applications are according to the human society development law, as a whole. The period of economic standstill is generating an intense creative activity in the domain of science and engineering which also resulting in great achievements in the field of electron accelerators. This paper presents the basic principle of the electron beam applications and the accelerators required characteristics for their present and potential applications in the domains: radiation sources, diagnostics, radiation processing, energetics, environment, defense and basic sciences. All these are correlated to the new generation of accelerators which, for the acceleration process, may employ electromagnetic fields generated by standard sources, atomic lasers, free electron lasers, Cerenkov effect, Smith - Purcell effect, electron beams, plasma, excited atoms into a crystal or other sources. Some more ...

International Nuclear Information System (INIS)

BaTi_0_._9(Ni_1_/_2W_1_/_2)_0_._1O_3 ceramics were fabricated and their dielectric properties were investigated. With the sintering temperature increasing from 1250 to 1280 deg. C, the grain size abruptly increases from 1-2 to 20-40 #mu#m, accompanying significant changes in dielectric response. The samples with larger grains exhibit giant dielectric constant characteristics, which are considered to be mainly attributed to the domain boundary effect. The activation energies of the dielectric relaxation E_r_e_l_a_x=0.325 eV reveal the existence of microdomains in larger grains. The ac conductivity results also give the evidence of the domain boundary effect in the present ceramics.

British Library Electronic Table of Contents (United Kingdom)

Abstract: The basement of the South China Sea (SCS) and adjacent areas can be divided into six divisions (regions) - Paleozoic Erathem graben-faulted basement division in Beibu Gulf, Paleozoic Erathem strike-slip pull-apart in Yinggehai waters, Paleozoic Erathem faulted-depression in eastern Hainan, Paleozoic Erathem rifted in northern Xisha (Paracel), Paleozoic Erathem strike-slip extending in southern Xisha, and Paleozoic-Mesozoic Erathem extending in Nansha Islands (Spratly) waters. The Pre-Cenozoic basement in the SCS and Yunkai continental area are coeval within the Tethyan tectonic domain in the Pre-Cenozoic Period. They are formed on the background of the Paleo-Tethyan tectonic domain, and are important components of the Eastern Tethyan multi-island-ocean system. Three branches of t...

Science.gov (United States)

An improved method of generating angle-domain common-image gathers (ADCIGs) by VSP reverse time migration (RTM) is introduced in this paper. The formula which is used to compute the receiver wavefield for VSP RTM is modified by adding an amplitude correction term in order to conveniently output amplitude-preserved ADCIGs. Compared with the surface seismic data, VSP data contains much richer wavefields. However, the direct and downgoing waves can bring about serious imaging artifacts in ADCIGs, especially the direct wave. The feasibility and validity of this method is demonstrated by both numerical and real VSP data from western China. Thus, the ADCIGs from this method can provide reliable basic data for VSP migration velocity analysis, VSP AVO/AVA analysis, and inversion.

CERN Document Server

Feature selection refers to the problem of selecting relevant features which produce the most predictive outcome. In particular, feature selection task is involved in datasets containing huge number of features. Rough set theory has been one of the most successful methods used for feature selection. However, this method is still not able to find optimal subsets. This paper proposes a new feature selection method based on Rough set theory hybrid with Bee Colony Optimization (BCO) in an attempt to combat this. This proposed work is applied in the medical domain to find the minimal reducts and experimentally compared with the Quick Reduct, Entropy Based Reduct, and other hybrid Rough Set methods such as Genetic Algorithm (GA), Ant Colony Optimization (ACO) and Particle Swarm Optimization (PSO).

Science.gov (United States)

We solve an R -linear problem for a multiple-connected circular domain in a class of doubly periodic functions in analytic form by a method of functional equations. This problem models transport properties of two-dimensional composite materials made from a collection of disks embedded in an otherwise uniform host.

Energy Technology Data Exchange (ETDEWEB)

This publication of the Areva Group, a world nuclear industry leader, provides information on the energy in many domains. This issue deals with the nuclear fuel cycle, the biofuels, the everyday geothermal power, the Unites States energy supply and types, the Bertrand Picard solar aircraft, the kyoto protocol and the wind power leaders. A special chapter is devoted to the renaissance of solar homes. (A.L.B.)

International Nuclear Information System (INIS)

MOX fuel has been one of the mature nuclear fuels which can be used in light water nuclear power plant now. The development status in this domain in foreign countries, the major influence of MOX fuel on reactor performance and the countermeasures are introduced in this paper. The application of MOX fuel in China's PWR is discussed in the end. (authors)

Energy Technology Data Exchange (ETDEWEB)

With the aim of an experimental check on the validity of the theory of molecular recognition, the authors have carried out the chemical-enzymatic synthesis and cloning of the gene of human calcitonin and also of the genes of antisense polypeptides to human calcitonin and miniproinsulin. It has been shown that recombinant plasmids obtained on the basis of these synthetic genes are capable of ensuring the biosynthesis of the given polypeptides in E. coli cells as hybrid proteins with the IgG-binding domain of staphylococcal protein A.

Energy Technology Data Exchange (ETDEWEB)

Researchers investigated several supercomputer architectures in the context of assessing their performance in solving PDE problems. Main results are: assessed various classes of paralled and vector supercomputers and parallel software issues toward solving PDE problems; developed a multipipeline networking technique for compound vector processing; developed an orthogonal multiprocessor for large-grain scientific computations; improved parallel efficiency of a domain decomposition method, the DD algorithm.

Energy Technology Data Exchange (ETDEWEB)

It is necessary that reclaimed land from open pit mining operations has completely settled before it can be returned to the public domain. This paper reports on instrumentation installed to observe settlement of the spoil and behaviour of a prototype foundation on reclaimed land in Alberta, Canada. 6 refs., 7 figs.

Energy Technology Data Exchange (ETDEWEB)

The baryogenesis process in the early hot universe is investigated by means of relativistic kinetic theory. An exact solution to the kinetic equations for supermassive bosons serves to refine previous results: the optimum baryon-production domain is now complemented by bosons of low mass, thus removing the cosmological lower bound that had limited the mass of superheavy bosons. 14 references.

CERN Document Server

By using a laser and maser in tandem, it is possible to obtain laser action in the hot exhaust gases involved in heat engine operation. Such a "quantum afterburner" involves the internal quantum states of working gas atoms or molecules as well as the techniques of cavity quantum electrodynamics and is therefore in the domain of quantum thermodynamics. As an example, it is shown that Otto cycle engine performance can be improved beyond that of the "ideal" Otto heat engine.

UK PubMed Central (United Kingdom)

The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical aspects of cell motility including FA disassembly and protrusion of the...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The classical stochastic approximation methods are shown to yield algorithms to solve several formulations of the PAC learning problem defined on the domain [o,1]{sup d}. Under some assumptions on different ability of the probability measure functions, simple algorithms to solve some PAC learning problems are proposed based on networks of non-polynomial units (e.g. artificial neural networks). Conditions on the sizes of these samples required to ensure the error bounds are derived using martingale inequalities.

UK PubMed Central (United Kingdom)

SummaryThe transcriptional co-repressor SMRT utilizes two major receptor interacting domains (RID1 and RID2) to mediate nuclear receptor (NR) signaling through epigenetic modification....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Peroxisome proliferator activated receptor-{gamma} (PPAR{gamma}) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPAR{gamma} ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPAR{gamma}. Structural and functional studies of receptor-ligand interactions reveal the molecular basis of PPAR{gamma} discrimination of various naturally occurring fatty acid derivatives.

Energy Technology Data Exchange (ETDEWEB)

The macroscopic behavior of magnetostrictive materials results from domain evolutions occurring at a microscopic scale. The author shows how to compute magnetization and magnetostriction curves by appraising the behavior of the underlying microstructures. The method hinges on an averaging device (Young measures), which allows one to pass from the microscopic to the macroscopic scale. He takes into account the kinematical constraints on the accommodation of elastic effects, and he highlights the role of material symmetry in the selection of energetically optimal microstructures.

UK PubMed Central (United Kingdom)

The retina-specific ATP-binding cassette (ABC) transporter, ABCA4, is essential for transport of all-trans-retinal from the rod outer segment discs in the retina and is associated with...Full Text Available

UK PubMed Central (United Kingdom)

Among important candidates for babesial vaccines are apical complex proteins, including rhoptry-associated protein 1 (RAP-1) from Babesia bovis and B. bigemina, which...Full Text Available

International Nuclear Information System (INIS)

The paper considered the vibration signals of rotating equipment as cyclo stationary signals through analyzing the features of this kind of signals. Based on the analytic method of cyclic spectrum density, the paper pointed out that the impact frequency could be extracted effectively with the help of scanning cyclic frequency domain. The validity of the method of cyclic spectrum density is proved by simulating signals and the method is applied to the diagnosis of rolling bearings. (authors)

Energy Technology Data Exchange (ETDEWEB)

Large rigid-body domain movements are critical to GroEL-mediated protein folding, especially apical domain elevation and twist associated with the formation of a folding chamber upon binding ATP and co-chaperonin GroES. Here, we have modeled the anisotropic displacements of GroEL domains from various crystallized states, unliganded GroEL, ATP?S-bound, ADP-AlFx/GroES-bound, and ADP/GroES bound, using translation-libration-screw (TLS) analysis. Remarkably, the TLS results show that the inherent motions of unliganded GroEL, a polypeptide-accepting state, are biased along the transition pathway that leads to the folding-active state. In the ADP-AlFx/GroES-bound folding-active state the dynamic modes of the apical domains become reoriented and coupled to the motions of bound GroES. The ADP/GroES complex exhibits these same motions, but they are increased in magnitude, potentially reflecting the decreased ...

UK PubMed Central (United Kingdom)

Two cellular DNA regions representing common domains for proviral DNA integration ( Mlvi -1 and Mlvi -2) have been identified in Moloney murine leukemia virus-induced rat thymic lymphomas. Cellular...Full Text Available

CERN Document Server

We consider a nonlinear reaction-diffusion equation settled on the whole euclidean space. We prove the well-posedness of the corresponding Cauchy problem in a general functional setting, namely, when the initial datum is uniformly locally bounded in L^2. Then we adapt the short trajectory method to establish the existence of the global attractor and, if the space dimension is at most 3, we also find an upper bound of its Kolmogorov's entropy.

UK PubMed Central (United Kingdom)

A series of translocation break points found in a subset of human acute leukemias have one of the breaks on human chromosome 11q23. This region has recently been cloned and a large gene, ALL-1, with...Full Text Available

UK PubMed Central (United Kingdom)

Positioning of release factor eRF1 toward adenines and the ribose-phosphate backbone of the UAAA stop signal in the ribosomal decoding site was studied using messenger RNA (mRNA) analogs containing...Full Text Available

CERN Document Server

Leveraging the potential power of even small handheld devices able to communicate wirelessly requires dedicated support. In particular, collaborative applications need sophisticated assistance in terms of querying and exchanging different kinds of data. Using a concrete example from the domain of mobile learning, the general need for information dissemination is motivated. Subsequently, and driven by infrastructural conditions, realization strategies of an appropriate middleware service are discussed.

British Library Electronic Table of Contents (United Kingdom)

We investigate an application of the method of fundamental solutions (MFS) to the one-dimensional inverse Stefan problem for the heat equation by extending the MFS proposed in [5] for the one-dimensional direct Stefan problem. The sources are placed outside the space domain of interest and in the time interval (-T,T). Theoretical properties of the method, as well as numerical investigations, are included, showing that accurate and stable results can be obtained efficiently with small computational cost.

UK PubMed Central (United Kingdom)

Arf GTPases control vesicle formation from different intracellular membranes and are regulated by Arf guanine nucleotide exchange factors (GEFs). Outside of their conserved catalytic domains, known...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Contributions to the population dose due to medical applications of ionising radiation are presented. It appears that contributions due to radiotherapy and X ray diagnosis are of comparable magnitude. To account for the age dependency of the radiation risks, contributions in terms of somatically significant dose equivalent are calculated as 0.3 mSv per caput per annum for X ray diagnosis and as 0.2 mSv per caput per annum for radiotherapy, the latter referring to only doses to organs outside the target volume. (author).

International Nuclear Information System (INIS)

In the case of inelastic scattering of alpha particles to the 3"+ state, the averaged angular distributions show a characteristic shape, corresponding to the excitation of such an unnatural parity state by alpha particles in the compound nucleus process. The modified Hauser-Feshbach cross-section calculations give a good description of the averaged distributions for the alpha particle scattering to the 3"+ state and the compound nucleus parameters could be extracted. The calculations of the compounds nucleus contributions to the other states in the case of 24 MeV alpha particle scattering from "2"8Si show that this contribution is not negligible and in the case of the scattering to the 4"+ state seems to be dominant. (Z.M.).

UK PubMed Central (United Kingdom)

Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites of superoxide...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Abstract: [public affairs, ethical currents, Ireland, social research ethics] Liam Frink is contributing editor of Ethical Currents, the AN column of the AAA Committee on Ethics.

Science.gov (United States)

... written history concerning the use of the military working dogs in Vietnam. ... oral) to compile a historical account of the military working dog in Vietnam ...

UK PubMed Central (United Kingdom)

To evaluate the contribution of genetic influences on the individual variation in plateau serum salicylate levels, salicylate metabolism was studied in seven pairs of identical and six pairs of fraternal...Full Text Available

International Nuclear Information System (INIS)

The collection comprises 16 contributions; all of them were input to INIS

UK PubMed Central (United Kingdom)

The Second Kitasato Symposium: New Prospects for Cytokines brought together researchers and rheumatologists to consider the essential role of cytokines in health and their contributions to autoimmunity....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The most profitable terrain in Romania is already sold. Investors are now looking for new wind power sites. The contribution presents details. (orig.)

CERN Document Server

We briefly review capabilities and requirements for future instrumentation in UV- and X-ray astronomy that can contribute to advancing our understanding of the diffuse, highly ionised intergalactic medium.

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International Nuclear Information System (INIS)

We investigate the effects of the velocity-dependent force on the magnetic form factors and magnetic moments of odd-Z nuclei. The form factors are calculated with the harmonic-oscillator wavefunctions. It is found that the contributions of the velocity-dependent force manifest themselves in the very large momentum transfer region (q?4 fm-1). In the low and medium q region the contributions of the velocity-dependent force are very small compared with those without this force. However, in the high-q region the contributions of the velocity-dependent force are larger than the normal form factors. The diffraction structures beyond the existing experimental data are found after the contributions of the velocity-dependent force are included. The formula of the correction to the single particle magnetic moment due to the velocity-dependent force is reproduced exactly in the long-wavelength limit (q=0) of the ...

Science.gov (United States)

Jan 7, 2010 ... Deforestation. The environmental implications of the word are as numerous as the syllables. And scientists like Jim Collatz have the job of ...

UK PubMed Central (United Kingdom)

Astaxanthin (ATX) is a dietary carotenoid of crustaceans and fish that contributes to their coloration. Dietary ATX is important for development and survival of salmonids and crustaceans and has been...Full Text Available

International Nuclear Information System (INIS)

The Ra, Th, and K-40 content of the most important phosphate fertilizers used and authorized in the FRG was determined by #gamma#-spectroscopy. The results, together with statistical data on the consumption and use of fertilizers, were used for an estimation of the contribution of #gamma#-radiation from phosphate fertilizers to the external population exposure in the FRG. (orig./AK).

International Nuclear Information System (INIS)

In this paper, we study the J/#psi#(#UPSILON#) production in Z boson decay in a color-singlet model (CSM). We calculate the next-to-leading-order (NLO) QCD correction to Z#->#quarkonium+QQ, the dominant contribution in the CSM, with the vector and axial-vector parts in the ZQQ vertex being treated separately. The results show that the vector and axial-vector parts have the same K factor (the ratio of the NLO result to the leading-order result) 1.13 with the renormalization scale #mu#=2m_c and m_c=1.5 GeV, and the K factor falls to 0.918 when applying the Brodsky, Lepage, and Mackenzie (BLM) renormalization scale scheme with obtained #mu#_B_L_M=2.28 GeV and m_c=1.5 GeV. By including the contributions from the next-dominant ones, the photon and gluon fragmentation processes, the branching ratio for Z#->#J/#psi#_p_r_o_m_p_t+X is (7.3-10.0)x10"-"5 with the uncertainty consideration for the renormalization scale and charm quark mass. The ...

Energy Technology Data Exchange (ETDEWEB)

Accelerators can not be improved without the development of adequate beam instruments and diagnostic tools. This year this statement is particularly right: a lot of contributions are dedicated to beam monitoring and to the design of new beam monitors based on original technologies. This document gathers about 100 contributions.

International Nuclear Information System (INIS)

A general expression for the current-density distribution of a focused-ion beam (FIB) in the chromatic-aberration region is set up in the form of a definite integral. With the experimentally obtained ion-energy distribution of a liquid-metal ion source, its contribution to the FIB current-density distribution is estimated. Calculated results explain the wide-exponential tail of a FIB.

Energy Technology Data Exchange (ETDEWEB)

The contribution of pulsar accelerated nuclei to the cosmic rays inside the Galaxy is calculated assuming that a significant part of the pulsar rotational energy is lost on acceleration of iron nuclei extracted from the surface of the neutron star. Different models of the galactic pulsar population are discussed. It is shown that the best description of the observed cosmic ray spectrum and the mass composition between a few 10{sup 15} eV and a few 10{sup 18} eV is obtained for the model B of Lorimer et al. (1993)

UK PubMed Central (United Kingdom)

In superior cervical ganglion (SCG) neurons calcium-induced calcium release (CICR), mediated by ryanodine receptors (RyRs), contributes to stimulation-evoked intracellular calcium ([Ca²⁺]_i)...Full Text Available

International Nuclear Information System (INIS)

The present investigation was conducted at Ismaillia Research Station-Agricultural Research Center, Ismaillia Governorate, during the two successive seasons of 2000 and 2001. Two varieties of peanut (Arachis hypogaea L) namely Giza 4 and Giza 5 were treated with gamma ray doses; 10,15, 20, 25 Kr in order to induce genetic variability and to study the importance of the relative contribution of peanut yield components by employing some statistical procedures, i.e. simple correlation, multiple linear regression and stepwise regression analysis. The results showed that, there was significant positive correlation between seed yield/plant and no. of pods/plant, 100 seed weight, shelling percentage and pod yield/plant, and there was significant positive correlation between pod yield/plant and no of seed/plant,100 pod weight and 100 seed weight. The multiple linear regression analysis clearly showed that the relative contribution (R"2%) of the yield ...

Energy Technology Data Exchange (ETDEWEB)

The fluid-induced vibration level of instrumented capsule, which was manufactured for fuel irradiation test at the reactor core of HANARO, was investigated. For this purpose, the instrumented capsule was loaded at the OR site of the HANARO design verification test facility that could simulate identical flow condition as the HANARO core. Then, vibration signals of the instrumented capsule subjected to various flow conditions were measured by using vibration sensors. In time domain analysis, maximum amplitudes and RMS values of the measured acceleration and displacement signals were obtained. By using frequency domain analysis, frequency components of the fluid-induced vibration were analyzed. In addition, natural frequencies of the instrumented capsule were obtained by performing modal test. The frequency analysis results showed that the natural frequency components near 7.5Hz and 17.5Hz were dominant in the fluid-induced vibration signal. The ...

Energy Technology Data Exchange (ETDEWEB)

In this work, a comprehensive model including heat transfer, fluid flow and solidification was used to evaluate the performance of a novel delivery system for a single-belt steel casting process. This near-net-shape casting, although still in development, is one of the most promising routes for casting of low-carbon steel in large scale. This paper focuses on the performance of a low-Re {kappa}-{epsilon} model that was employed to simulate the three-dimensional turbulent flows fully-coupled with heat transfer and macroscopic solidification. Simulations were run for the intended conditions of caster operation, and the results obtained with the {kappa}-{epsilon} were compared with the results obtained with an ad hoc viscosity model, where the molecular viscosity was boosted 100 times, uniformly throughout the computational domain. A semi-analytical solution was employed for validating the models and the results showed that the ad hoc viscosity model overestimated the ...

International Nuclear Information System (INIS)

In this study, WO3 thin films were grown on glass substrates using an aqueous solution containing tungstate (NH4)2WO4 as precursor. The substrate temperature incremented from 250 to 500 deg. C, by steps of 50 deg. C. The structural properties were investigated using XRD, atomic force microscopy and scanning electronic microscopy techniques. Microprobe analyses showed that a balanced stoichiometric composition was obtained for thin films prepared at Ts = 350 and 400 deg. C. The X-ray diffraction analyses showed different structure crystallography in function of the substrate temperature. Moreover, films deposited at 400 deg. C were annealed in air for 2 h at 450 and 500 deg. C, respectively and the structural changes due to heat treatment were studied. Finally, the optical properties of these films were carried out using optical measurements of transmittance T(?) and reflectance R(?) spectra in 300-1800 nm domain. The refractive and absorption indexes, n and k were ...

Science.gov (United States)

In this article, we describe the development and preliminary psychometric properties of the Structured Interview of Personality Organization (STIPO), a semistructured interview designed for the dimensional assessment of identity, primitive defenses, and reality testing, the three primary content domains in the model of personality health and disorder elaborated by Kernberg (1984; Kernberg & Caligor, 2005). Results of this investigation, conducted in a clinical sample representing a broad range of personality pathology, indicate that identity and primitive defenses as operationalized in the STIPO are internally consistent and that interrater reliability for all 3 content domains is adequate. Validity findings suggest that the assessment of one's sense of self and significant others (Identity) is predictive of measures of positive and negative affect, whereas the maladaptive ways in which the subject uses his or her objects for purposes of ...

Energy Technology Data Exchange (ETDEWEB)

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. The authors have investigated whether common cellular DNA domains might be rearranged, possibly by HBV integration, in human primary liver tumors. Unique cellular DNA sequences adjacent to an HBV integration site were isolated from a patient with hepatitis B surface antigen-positive hepatocellular carcinoma. These probes detected rearrangement of this cellular region of chromosomal DNA in 3 of 50 additional primary liver tumors studied. Of these three tumor samples, two contained HBV DNA, without an apparent link between the viral DNA and the rearranged allele; HBV DNA sequences were not detected in the third tumor sample. By use of a panel of somatic cell hybrids, these unique cellular DNA sequences were shown to be located on chromosome 4. Therefore, this region of chromosomal DNA might be implicated in the formation of different tumors at one step of ...

International Nuclear Information System (INIS)

Focused ion beam (FIB) milling is a powerful and versatile tool for the maskless fabrication of structures and devices at micro- and nanometer scales. The approach is based on the milling and deposition capabilities of a focused ion beam, where the latter is achieved by ion-beam-assisted decomposition of a metalorganic gas precursor of the specific material that has to be deposited. The combination of FIB and scanning electron microscopy in the same unit (so-called dual-beam unit) further expands the capabilities of the approach by the possibility of performing electron-beam-assisted deposition and inspection. Permalloy nanowires with electrical contacts patterned by FIB-Pt deposition were prepared in the dual-beam unit. Various types of notches to pin magnetic domain walls were additionally fabricated by means of FIB. The fabrication parameters for a structural modification of the Permalloy structures without too strongly affecting the material properties were ...

International Nuclear Information System (INIS)

The paper develops a new design procedure for simultaneous coordinated designing of the thyristor controlled series capacitor (TCSC) damping controller and power system stabilizer (PSS) in multi-machine power system. The coordinated design problem of PSS and TCSC damping controllers over a wide range of loading conditions is converted to an optimization problem with the time domain-based objective function that is solved by a particle swarm optimization (PSO) technique which has a strong ability to find the most optimistic results. By minimizing the proposed fitness function in which oscillatory characteristics between areas are included and thus the interactions among the TCSC controller and PSS under transient conditions in the multi-machine power system are improved. To ensure the robustness of the proposed stabilizers, the design process takes a wide range of operating conditions into account. The effectiveness of the proposed controller is demonstrated through ...

CERN Document Server

Aliasing, or sharing, is prominent in many domains, denoting that two differently-named objects are in fact identical: a change in one object (memory cell, circuit terminal, disk block) is instantly reflected in the other. Languages for modelling such domains should let the programmer explicitly define the sharing among objects or expressions. A DSL compiler may find other identical expressions and share them, implicitly. Such common subexpression elimination is crucial to the efficient implementation of DSLs. Sharing is tricky in embedded DSL, since host aliasing may correspond to copying of the underlying objects rather than their sharing. This tutorial summarizes discussions of implementing sharing in Haskell DSLs for automotive embedded systems and hardware description languages. The technique has since been used in a Haskell SAT solver and the DSL for music synthesis. We demonstrate the embedding in pure Haskell of a simple DSL with a ...

British Library Electronic Table of Contents (United Kingdom)

We describe a method for the analysis of multi-site phosphorylation in serine/threonine (Ser/Thr)-rich protein sequences. Site-specific mutagenesis was used to introduce tryptic cleavage sites in the serine glutamine/threonine glutamine cluster domain (SCD) of the human checkpoint protein kinase (Chk2). The mutant proteins were shown to autophosphorylate on residues that are inducibly phosphorylated when mammalian cells are exposed to ionizing radiation (serine 33/35, serine 516, threonine 68 and threonine 432). Five Ser/Thr clusters within the SCD were flanked by arginine or lysine residues to produce tryptic peptides for nanospray liquid chromatography (nanoLC)/linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry. Phosphorylation sites were assigned usin...

CERN Document Server

In this paper we analyze the Hilbert boundary-value problem of the theory of analytic functions for an $(N+1)$-connected circular domain. An exact series-form solution has already been derived for the case of continuous coefficients. Motivated by the study of the Hall effect in a multiply connected plate we extend these results by examining the case of discontinuous coefficients. The Hilbert problem maps into the Riemann-Hilbert problem for symmetric piece-wise meromorphic functions invariant with respect to a symmetric Schottky group. The solution to this problem is derived in terms of two analogues of the Cauchy kernel, quasiautomorphic and quasimultiplicative kernels. The former kernel is known for any symmetry Schottky group. We prove the existence theorem for the second, quasimultiplicative, kernel for any Schottky group (its series representation is known for the first class groups only). We also show that the use of an automorphic kernel requires the ...

Energy Technology Data Exchange (ETDEWEB)

This study examines the sensitivity of the travel time distribution predicted by a reference case model to (1) scale of representation of the model parameters, (2) size of the model domain, (3) correlation range of log-transmissivity, and (4) cross correlations between transmissivity and effective thickness. The basis for the reference model is the preliminary stochastic travel time model previously documented by the Basalt Waste Isolation Project. Results of this study show the following. The variability of the predicted travel times can be adequately represented when the ratio between the size of the zones used to represent the model parameters and the log-transmissivity correlation range is less than about one-fifth. The size of the model domain and the types of boundary conditions can have a strong impact on the distribution of travel times. Longer log-transmissivity correlation ranges cause larger variability in the predicted travel times. ...

International Nuclear Information System (INIS)

The dynamical signals of sound pressure oscillation in natural convective subcooled boiling system are obtained by using computer data acquisition technique. Through frequency-domain analysis of typical dynamical data, combined with study on the acquired time series of sound pressure, are observed and explained. The time-frequency phenomena, such as the onset of shock wave, frequency doubling relation of sound pressure, combination of sound frequency spectrum peaks etc., which describe the characteristics of natural convective subcooled boiling system are presented. Furthermore, based on frequency spectra of sound pressure, related eigen vectors are defined and established and with dynamical clustering method, regime recognition for the dynamical process of system is carried out. Results of recognition are consistent with that of qualitative analysis of time series, which is of great significance for automatic monitoring system of nuclear safety, expertise ...

Science.gov (United States)

The Drosophila melanogaster tissue-specific transcription factor NTF-1 was originally identified in vitro as a protein that could bind to and activate transcription from the Dopa decarboxylase (Ddc) gene. A structure-function analysis of NTF-1 led to the identification of a discrete amino-terminal activation domain. Here, we report that an NTF-1 mutant lacking the activation domain acts as a trans-dominant inhibitor of NTF-1 activation in tissue culture cells by forming inactive heterodimers with the full-length protein. Ectopically expressing this dominant-negative protein or the full-length protein in developing Drosophila embryos leads to dire developmental consequences. Overexpressing the trans-dominant NTF-1 leads to lethality, while overexpressing full-length NTF-1 results in both lethality and morphogenetic defects. Our results suggest that both the activity and the regulation of NTF-1 are critical for viability and proper development of ...

CERN Document Server

We point out that the moduli sector of the $(2,2)$ string compactification with its nonperturbatively preserved non-compact symmetries is a fertile framework to study global topological defects, thus providing a natural source for the large scale structure formation. Based on the target space modular invariance of the nonperturbative superpotential of the four-dimensional N=1 supersymmetric string vacua, topologically stable stringy domain walls are found. They are supersymmetric solutions, thus saturating the Bogomolnyi bound. It is also shown that there are moduli sectors that allow for the global monopole-type and texture-type configurations whose radial stability is ensured by higher derivative terms.

CERN Document Server

Stable quotient spaces provide an alternative to stable maps for compactifying spaces of maps. When the target is projective space and the domain curve has genus 1, these are smooth proper Deligne-Mumford stacks. In this paper we study the associated coarse moduli schemes. We show these schemes are projective, rationally connected and have Picard number 2. Then we give generators for the Picard group, compute the canonical divisor, and the cones of ample and effective divisors. In certain cases, we also give a closed formula for the Poincar\\'{e} polynomial.

British Library Electronic Table of Contents (United Kingdom)

The mechanism of abrupt increase of the giant magneto impedance (GMI) ratio in the ion irradiated Co-based amorphous ribbon has been investigated. The grazing incident X-ray diffraction and transmission electron microscope were used to characterize the samples before and after ion irradiation. The GMI-ratio considerably increased in the ion irradiated samples and the GMI response showed strong dependence on the driving frequencies. The Barkhausen noise (BN) signals are increased for the Ar ion irradiated sample with dose of 1x10^1^7 ion/cm^2. The results are interpreted in terms of GMI variation associated with domain wall dynamics.

CERN Document Server

We consider non-relativistic systems in quantum mechanics interacting through the Coulomb potential, and discuss the existence of bound states which are stable against spontaneous dissociation into smaller atoms or ions. We review the studies that have been made of specific mass configurations and also the properties of the domain of stability in the space of masses or inverse masses. These rigorous results are supplemented by numerical investigations using accurate variational methods. A section is devoted to systems of three arbitrary charges and another to molecules in a world with two space-dimensions.

CERN Document Server

Similarity searching finds application in a wide variety of domains including multilingual databases, computational biology, pattern recognition and text retrieval. Similarity is measured in terms of a distance function edit distance in general metric spaces, which is expensive to compute. Indexing techniques can be used reduce the number of distance computations. We present an analysis of various existing similarity indexing structures for the same. The performance obtained using the index structures studied was found to be unsatisfactory . We propose an indexing technique that combines the features of clustering with M tree(MTB) and the results indicate that this gives better performance.

International Nuclear Information System (INIS)

Magnetic materials such as yttrium iron garnet (YIG) are of great importance for its magneto-optic properties and for their potential applications in the domain of optical telecommunications. The deposition of thin films of YIG, on quartz or GGG (gadolinium gallium garnet) substrate, was performed using radio frequency non reactive magnetron sputtering, followed by high temperature annealing which is needed to enhance the crystallinity of the layers. Rutherford backscattering spectrometry RBS was used to determine the thickness and stoichiometry of the performed layers in order to investigate correlations between growth conditions and the quality of the final material. RBS measurements showed the influence of the deposition time and the temperature substrate on the film growth and its stoichiometry. (author)

British Library Electronic Table of Contents (United Kingdom)

In this work, we report the preparation of lead titanate (PT) nanoceramics (with an average grain size of ~200nm in diameter) by using hydrothermal PT nanoparticles as start materials and characterized the dielectric and ferroelectric properties. The dielectric constant of the ceramic was found to be ~180 (at 1kHz) at room temperature and reached a maximum value of 8330 at ~490^oC, suggesting that the Curie temperature of the nanoceramics is consistent with the known value of PT crystals. Ferroelectric domains and hysteresis loops were obtained through piezoelectric force microscopy measurements, which provide direct and clear evidence for the ferroelectricity in the nanoceramic samples.

Energy Technology Data Exchange (ETDEWEB)

Theoretical analysis of the electric field bifurcation is made for the LHD plasma. For given shapes of plasma profiles, a region of bifurcation is obtained in a space of the plasma parameters. In this region of plasma parameters, the electric field domain interface is predicted to appear in the plasma column. The reduction of turbulent transport is expected to occur in the vicinity of the interface, inducing a internal transport barrier. Within this simple model, the plasma with internal barriers is predicted to be realized for the parameters of T{sub e}(0) {approx} 2 keV and n(0) {approx_equal} 10{sup 18} m{sup -3}. (author)

CERN Document Server

P. Galenko et al. proposed a modified Cahn-Hilliard equation to model rapid spinodal decomposition in non-equilibrium phase separation processes. This equation contains an inertial term which causes the loss of any regularizing effect on the solutions. Here we consider an initial and boundary value problem for this equation in a two-dimensional bounded domain. We prove a number of results related to well-posedness and large time behavior of solutions. In particular, we analyze the existence of bounded absorbing sets in two different phase spaces and, correspondingly, we establish the existence of the global attractor. We also demonstrate the existence of an exponential attractor.

Energy Technology Data Exchange (ETDEWEB)

Approximate methods are presented for solving nonlinear boundary value problems with an unknown (free) boundary, such as the Stefan problem in heat conductivity. Examples of this kind of problems in thermal physics, hydrodynamics, elasticity, and plasma physics are examined. Attention is given to the principal computational methods for solving stationary problems for second- and fourth-order elliptic equations, such as the domain transformation and penalty methods. To illustrate the capabilities of the methods presented here, examples of numerical solutions are presented for various specific applied problems. 255 references.

International Nuclear Information System (INIS)

Monitoring and diagnostic systems are of main importance for a safe and efficient operation of nuclear power plants. The author describes new developments with respect to vibration monitoring with a functional extension in the time domain for den secondary circuit, the development of a local system for the surveillance of rotating machines, the structure-borne sound monitoring with improvement of event analysis, esp. the loose part locating, leakage monitoring with a complete system for humidity measurement, and the development of a common platform for all monitoring and diagnostic systems, that allows an efficient access for comparison and cross references.

Energy Technology Data Exchange (ETDEWEB)

In the framework of the negotiations on the climatic changes, beginning at Rio in 1992, the France received an UN conference from the 4 to 15 of september 2000. This conference determined the necessary actions for the Kyoto protocol validation. This document presents in two part the program of these days. The first part is devoted to the world government policy and the second part defines the french actions decided to fight against the climatic change. A glossary of the main terms adapted to the climatic change domain, is also provided. (A.L.B.)

International Nuclear Information System (INIS)

Each choice of an arbitrary nonzero function f of the four immersion parameters is shown to determine 16N[f] distinguishable classes of two-parameter families of immersions of Einstein-Riemann spacetimes in six-dimensional flat spaces, where N[f] is the number of regular immersion parameter domains. The metric tensors, curvature tensors and the immersion loci are calculated in a closed form, and these calculations involve only finitely many algebraic operations. The presence of the arbitrary function provides the opportunity for study of the behaviour of multiple isolated singularities and/or 'shape' functions in general relativity.

Energy Technology Data Exchange (ETDEWEB)

The objectives of the research in the field of epidemiology , performed at the Belgian Nuclear Research Centre SCK-CEN are (1) to study cancer mortality and morbidity in nuclear workers in Belgium; (2) to document the feasibility of retrospective cohort studies in Belgium; (3) to participate in the IARC study. For radiobiology, the main objectives are: (1) to elucidate the mechanisms of the effects of ionizing radiation on the mammalian embryo during the early phase of its development, (2) to assess the genetic risks of maternal exposure to ionizing radiation, (3) to elucidate the mechanisms by which damage to the brain and mental retardation are caused in man after prenatal irradiation. The main achievements in these domains for 1997 are presented.

CERN Document Server

A method for simulating power law noise in clocks and oscillators is presented based on modification of the spectrum of white phase noise, then Fourier transforming to the time domain. Symmetric real matrices are introduced whose traces--the sums of their eigenvalues--are equal to the Allan variances, in overlapping or non-overlapping forms, as well as for the corresponding forms of the modified Allan variance. Diagonalization of these matrices leads to expressions for the probability distributions for observing a variance at an arbitrary value of the sampling or averaging interval $\\tau$, and hence for estimating confidence in the measurements. A number of applications are presented for the common power-law noises.

British Library Electronic Table of Contents (United Kingdom)

A scant body of literature addresses competencies needed for successful job development. This study aimed to identify competencies needed for this role. In this analysis, we observed employment specialists identified as successful in helping consumers obtain employment perform job development duties. We supplemented observations with interviews. Employment specialists possessed competencies in six domains: time management, advocacy, building partnerships with consumers, working as part of a team, face-to-face communication, and networking. The conceptual framework derived from this study can inform supported employment supervisors and researchers about the competencies that can strengthen supported employment teams.

Scientific Electronic Library Online (English)

Abstract in english In the last decade it has been experimentally found a periodic domain pattern arising in smectic C* liquid crystals in surface stabilized bookshelf geometry. Such a periodic texture appears after switching-off an external electric field, even in strong anchoring conditions. It has a static character and can be bidimensional, being dependent on both directions normal to the smectic planes and normal to the cell plates. In the present work an explanation to this phenomenon (more) is proposed. According to our model in the antiferroelectric phase the biperiodic texture is a threshold phenomenon, appearing for values of the spontaneous polarization greater than a critical value, whereas in the ferroelectric phase this type of bidimensional instability is hindered.

British Library Electronic Table of Contents (United Kingdom)

In this paper we present a new, accurate form of the heat balance integral method, termed the combined integral method (CIM). The application of this method to Stefan problems is discussed. For simple test cases the results are compared with exact and asymptotic limits. In particular, it is shown that the CIM is more accurate than the second order, large Stefan number, perturbation solution for a wide range of Stefan numbers. In the initial examples it is shown that the CIM reduces the standard problem, consisting of a PDE defined over a domain specified by an ODE, to the solution of one or two algebraic equations. The latter examples, where the boundary temperature varies with time, reduce to a set of three first order ODEs.

British Library Electronic Table of Contents (United Kingdom)

We have measured the frequency-dependent dielectric function of semi-crystalline polybutylene terephthalate (PBT) in the terahertz region between 100?GHz and approximately 2.8?THz. A characteristic band is observed around 2.38?THz. The intensity of this band is a good indicator of the degree of crystallinity of the different samples. A potential assignment of this band is proposed, based on the comparison with spectroscopic data of the structurally very similar polyethylene terephtalate (PET). Furthermore, the frequency-dependent index of refraction of PBT reveals more insight about the morphology and different thermal history of the samples under investigation.

International Nuclear Information System (INIS)

The p75 neurotrophin receptor (p75"N"T"R) is a death receptor which belongs to the tumor necrosis factor receptor super-family of membrane proteins. This study shows that p75"N"T"R retarded cell cycle progression by induced accumulation of cells in G0/G1 and a reduction in the S phase of the cell cycle. The rescue of tumor cells from cell cycle progression by a death domain deleted (#DELTA#DD) dominant-negative antagonist of p75"N"T"R showed that the death domain transduced anti-proliferative activity in a ligand-independent manner. Conversely, addition of NGF ligand rescued retardation of cell cycle progression with commensurate changes in components of the cyclin/cdk holoenzyme complex. In the absence of ligand, p75"N"T"R-dependent cell cycle arrest facilitated an increase in apoptotic nuclear fragmentation of the prostate cancer cells. Apoptosis of p75"N"T"R expressing cells occurred via the intrinsic mitochondrial pathway leading to a ...

Energy Technology Data Exchange (ETDEWEB)

In previous work the authors showed that on photolysis of Escherichia coli ribosomes in the presence of ({sup 3}H)tetracycline (TC) the major protein labeled is S7, and they presented strong evidence that such labeling takes place from a high-affinity site related to the inhibitory action of TC. In this work they use single protein omission reconstitution (SPORE) experiments to identify those proteins that are important for high-affinity TC binding to the 30S subunit, as measured by both cosedimentation and filter binding assays. With respect to both sedimentation coefficients and relative Phe-tRNA{sup Phe} binding, the properties of the SPORE particles they obtain parallel very closely those measured earlier, with the exception of the SPORE particle lacking S13. A total of five proteins, S3, S7, S8, S14, and S19, are shown to be important for TC binding, with the largest effects seen on omission of proteins S7 and S14. Determination of the protein compositions of the corresponding ...