n-acetylcysteine amide naca: Topics by WorldWideScience.org

Minocycline Synergizes with N-Acetylcysteine and Improves Cognition and Memory Following Traumatic Brain Injury in Rats

Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver failure in the United States. The only available treatment, N-acetylcysteine (NAC), has a limited...Full Text Available

2010-10-05

A Computer Program for Wing 'Stibsonic Aerodynamic Performance ...

BackgroundThere are no drugs presently available to treat traumatic brain injury (TBI). A variety of single drugs have failed clinical trials suggesting a role for drug combinations....Full Text Available

Radioprotection through cytokineliberation under N-actylcysteine; Radioprotektion durch Zytokinfreisetzung unter N-Acetylcystein

of Aspect Ratio 2 With NACA 0005-63 Thickness Distribution,. Cambered and Twisted for a Trapezoidal Span Load Distribution. NACA RM A50K27a,, ...

Amides useful as brain imaging agents

Backgrund: Interleukin-1, tumornecrosisfactor-{alpha} and interferon-{gamma} endogenously provide protection of the hematopoietic system against radiation. Thiols have already been used successfully as radioprotective agents. In this study the effect von N-acetylcysteine (NAC) on the release of interleukin-1{alpha} and {beta} (IL-1), interleukin-2 (IL-2), interferon-{gamma} (IFN-{gamma}) and tumornecrosisfactor-{alpha} (TNF-{alpha}) was assessed in an in vitro assay. Patients and Methods: Whole blood samples from 8 healthy volunteers were stimulated with 7.5 {mu}m/ml PHA. NAC was added at concentrations of 0.6, 6, 12 and 24 mmol/l. Subsequently the samples were irradiated with a dose of 18 Gy according to preceding validation experiments. Results: IL-1{alpha}, IL-1{beta} and IL-2: In comparison to simulation and radiation alone the addition of 0.6 and 6 mmol/l with IL-2 also 12 mmol/l, NAC resulted in a significant increase of the cytokine-concentrations. The ...

1996-02-01

Amides useful as brain imaging agents

Certain radioiodine containing amides useful as brain imaging agents are disclosed. The compounds of the subject invention are represented by the formula

1981-07-21

RESEARCH MEMORANDUM '- - NASA Technical Report Server (NTRS)

Certain radioiodine containing amides useful as brain imaging agents are disclosed. The compounds of the subject invention are represented by the formula.

Ocular Burn: Rinsing and Healing with Ionic Marine Solutions and Vegetable Oils

With NACA 0005-63 Thickness Distribution. NACA RM A52B08, 1952. . 15. l@ick, Charles W., and Olson, Robert N.: Flow Studies in the ...

British Library Electronic Table of Contents (United Kingdom)

Abstract Purpose: We investigated the effects of various rinsing and healing protocols on corneal wound repair and inflammation following alkali burn in rabbits. Methods: We conducted in vitro, in vivo and ex vivo studies. First, different rinse solutions were tested in vitro after incubation of ocular cells with methanol or NaOH. Cell viability was then assessed using the neutral red test (cytofluorometry). Second, NaOH was applied to rabbit corneas and associations of rinse solutions (NaCl 0.9% or controlled ionization marine solutions) with N-acetylcysteine or vegetable oils (from Calophyllum inophyllum and Aleurites moluccana) were tested in vivo. The regeneration of the corneal epithelium and the infiltration of inflammatory cells were evaluated using in vivo confocal microscopy and e...

2009-01-01

New Image - ONLY - Scan to PDF - NASA Technical Report Server (NTRS)

Lift, drag, and pitching moment of low-aspect-ratio wings at subsonic and supersonic speeds : twisted and cambered triangular wing of aspect ratio 2 with NACA 0005-63 thickness distribution

ratio 2 with NACA 0005-63 thickness distribution in streamwise planes, and twisted and cambered for a trapezoidal span load distribution has ...

1 - NASA Technical Report Server (NTRS)

No Abstract Available

1952-01-01

Changes in Amide-Linked and Ester Indole-3-Acetic Acid in Cotton Fruiting Forms during Their Development

having a triangular wing of aspect ratio 2 with NACA 0005-63 thickness distribution in streamwise planes, and twisted and cambered for a trape- ...

Preparation and evaluation of Tc-99m complexes of aromatic bridged amine-amide-thiol-thioether N_2S_2 ligands

The concentration of free indoleacetic acid (IAA) is high in cotton (Gossypium hirsutum L.) fruiting forms before anthesis, but is low at and for a few days after anthesis. Amide-linked...Full Text Available

1989-03-01

NACA '! - NASA Technical Report Server (NTRS)

Short communication.

Lift, drag, and pitching moment of low-aspect-ratio wings at subsonic and supersonic speeds : triangular wing of aspect ratio 4 with NACA 0005-63 thickness distribution, cambered and twisted for trapezoidal span load distribution

loading,W/S = k. 390 og~uda per squsre foot. Total rudder movement,. Total pedal movement, 30.64?. Radius of pedel about center of rotation,. 12 inches ...

Lift, drag, and pitching moment of low-aspect-ratio wings at subsonic and supersonic speeds : triangular wing of aspect ratio 2 with NACA 0005-63 thickness distribution, cambered and twisted for a trapezoidal span load distribution

No Abstract Available

1951-01-01

Vibrational Circular Dichroism: A developing spectroscopic technique for peptide and protein conformational studies

No Abstract Available

1951-01-01

B chain is a functional subunit of beta-bungarotoxin for inducing apoptotic death of human neuroblastoma SK-N-SH cells.

Electronic circular dichroism (ECD) of the n-#pi# and #pi# -#pi# transitions of the amide groups in the ultraviolet has become an indispensable tool for qualitative characterization of proteins in solution. Since the existence of such a spectrum (that is, of natural optical activity) comes from the three dimensional interaction of the chromophores in the molecule, CD is exquisitely sensitive to molecular conformation. However, in proteins, the amide transitions available in the near UV are limited in number and are broads and overlapping. Interactions among them yield information about the polymeric backbone, but since such amide electronic excitation are relatively delocalized, the resulting

1996-11-01

Small and neutral Tc"vO BAT, bisaminoethanethiol (N_2S_2) complexes for developing new brain imaging agents

beta-Bungarotoxin (beta-Bgt), a presynaptic phospholipase A(2) (PLA(2)) neurotoxin isolated from the venom of Bungarus multicinctus, consists of A chain and B chain. The goal of the present study is to explore the functional contribution of the two subunits to the toxicity of beta-Bgt. beta-Bgt was found to induce apoptotic death of SK-N-SH cells via elevating intracellular Ca(2+) and intracellular ROS production. Moreover, an activation of p38 MAPK was associated with the cytotoxicity of beta-Bgt. SB202190 (p38 MAPK inhibitor), N-acetylcysteine (antioxidant reagent), 1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid (BAPTA) (Ca(2+) chelator) and the inhibitors of Ca(2+) release from intracellular depots (ruthenium red and 2-aminoethoxydiphenyl borate) effectively attenuated the cytotoxicity of beta-Bgt. In sharp contrast to the inability of A chain, B chain was able to induce cytotoxic effects on SK-N-SH cells as beta-Bgt did. Abolishment of PLA(2) activity ...

2007-10-13

2,3-dihydroxybenzoic acid amides of tetraazaalkanes and tetraaza cycloalkanes

Bisaminoethanethiol (BAT) ligands with various gem-dimethyl and amide groups were prepared, and the corresponding neutral Tc-99m complexes were prepared and evaluated for their relative stabilities by ligand-exchange reactions. It was demonstrated that technetium complexes containing gem-dimethyl substituents have higher lipophilicities, whereas those with an amide group possess greater stability, which enhances ligand-exchange reaction. The most interesting observation was that the brain uptake in rats is not determined only by lipophilicity. Apparently, Tc-99m complexes with an amide functional group display lower brain uptakes in rats compared to those without an amide group. The brain uptake was strongly influenced by substituents on the BAT ligand. These factors are critically important and should be taken into consideration when designing Tc-99m-labeled agents for CNS receptor imaging.

1998-02-01

Small and neutral Tc{sup v}O BAT, bisaminoethanethiol (N{sub 2}S{sub 2}) complexes for developing new brain imaging agents

The present compounds are useful as specific sequestering agents for actinide (IV) ions. Also described is a method for the 2,3-dihydroxybenzamidation of azaalkanes.

1980-01-01

1 2 3 4

Simulation study of chiral two dimensional ultraviolet (2DUV) spectroscopy of the protein backbone

1998-02-01

Insect juvenile hormone analogues: effects of some terpenoid amide derivatives

Amide n –π^* and π-π^* excitations around 200 nm are prominent spectroscopic...Full Text Available

2010-06-09

Fourier-transform infrared anisotropy in cross and parallel sections of tendon and articular cartilage

A series of N-alkylamide epoxides have shown considerable selective activity against insects. The N-ethyl and 7,11-dichloro-N-ethyl derivatives showed particularly pronounced activity, and this paper...Full Text Available

1971-01-01

Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility.

BackgroundFourier Transform Infrared Imaging (FTIRI) is used to investigate the amide anisotropies at different surfaces of a three-dimensional cartilage or tendon block. With the...Full Text Available

Radioiodinated phenoxyacetic acid derivatives as potential brain imaging agents, 2; Structure-biodistribution relationship

Soluble epoxide hydrolase (sEH) plays an important role in the metabolism of endogenous chemical mediators involved in the regulation of blood pressure and inflammation. 1,3-Disubstituted ureas with a polar group located on the fifth atom from the carbonyl group of urea function are active inhibitors of sEH both in vitro and in vivo. However, their limited solubility in water and relatively high melting point lead to difficulties in formulating the compounds and poor in vivo efficacy. To improve these physical properties, the effect of structural modification of the urea pharmacophore on the inhibition potencies, water solubilities, octanol/water partition coefficients (log P), and melting points of a series of compounds was evaluated. For murine sEH, no loss of inhibition potency was observed when the urea pharmacophore was modified to an amide function, while for human sEH 2.5-fold decreased inhibition was obtained in the amide compounds. In ...

2005-05-19

Cyclopeptide alkaloids. Synthesis of the ring system and its ion affinity

In developing new brain imaging agents for single photon emission computed tomography (SPECT), we synthesized eleven radioiodinated phenoxyacetic acid derivatives and investigated the relationship between the chemical structure and in vivo characteristics. Biodistribution studies in mice revealed high initial brain uptake for all the compounds. Blood radioactivity level depended markedly upon the chemical stability of the compound. The alpha,alpha-dimethylester derivative, amide derivatives and diamine derivatives, which were stable to hydrolysis, showed low blood activity levels following intravenous administration. Disappearance of the ester and amide compounds from the brain was rapid. However, the diamine derivatives displayed improved retention in the brain. Compounds 3a and 4 possessed the best combination of high brain uptake and sufficient retention to be useful as potential brain imaging radiopharmaceuticals with SPECT devices.

1989-09-01

Characterization of Auxin Conjugates in Arabidopsis. Low Steady-State Levels of Indole-3-Acetyl-Aspartate, Indole-3-Acetyl-Glutamate, and Indole-3-Acetyl-Glucose1

Several examples of the 14-membered, para-bridged ring system of the cyclopeptide alkaloids have been synthesized via an active ester cyclization. The yield of monomeric cyclopeptide varied from 1 to 33% and was affected by the amino acid substitution pattern and amide conformation of the linear peptide precursors. Both the synthetic models and a naturally occurring cyclopeptide alkaloid, ceanothine B, bind monovalent (Li"+) and divalent (Ca"2"+, Mg"2"+) cations. 4 figures, 1 table.

Cathodic reduction of. cap alpha. -azidostyroles

Amide-linked indole-3-acetic acid (IAA) conjugates constitute approximately 90% of the IAA pool in the dicot Arabidopsis, whereas ester-linked conjugates and free IAA account for approximately...Full Text Available

2000-06-01

Besarhanamides A and B from the marine cyanobacterium Lyngbya majuscula

Cathodic reduction of non-terminal vinylaxides on Hg cathodes in the presence of electrophiles gives reasonable yields of N-acylated enamines in an electrochemically totally irreversible reaction. In the presence of added H-donors rather high selectivity for formation of saturated amides is achieveable. The influence of reaction conditions on product distribution is discussed.

1984-05-01

British Library Electronic Table of Contents (United Kingdom)

Besarhanamides A (1) and B (2) are fatty acid amides purified from the marine cyanobacterium, Lyngbya majuscula, collected from Pulau Hantu, Singapore. The structure determination of these secondary metabolites was carried out using extensive 2D NMR spectral data as well as chemical manipulations including the Marfey's method. In addition, besarhanamide A exhibited moderate toxicity with LD50 at 13mM in the brine shrimp toxicity bioassay.

2008-01-01

Rapamycin (sirolimus) protects against hypoxic damage in primary heart cultures via Na^+/Ca^2^+ exchanger activation

British Library Electronic Table of Contents (United Kingdom)

Aims: Rapamycin (sirolimus) is an antibiotic that inhibits protein synthesis through mammalian targeting of rapamycin (mTOR) signaling, and is used as an immunosuppressant in the treatment of organ rejection in transplant recipients. Rapamycin confers preconditioning-like protection against ischemic-reperfusion injury in isolated mouse heart cultures. Our aim was to further define the role of rapamycin in intracellular Ca^2^+ homeostasis and to investigate the mechanism by which rapamycin protects cardiomyocytes from hypoxic damage. Main methods: We demonstrate here that rapamycin protects rat heart cultures from hypoxic-reoxygenation (H/R) damage, as revealed by assays of lactate dehydrogenase (LDH) and creatine kinase (CK) leakage to the medium, by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-d...

2011-01-01

Delayed Afterdepolarization in Intact Canine Sinoatrial Node as a Novel Mechanism for Atrial Arrhythmia

British Library Electronic Table of Contents (United Kingdom)

Delayed Afterdepolarization in Sinoatrial Node. Introduction: Recent evidence indicates that spontaneous sarcoplasmic reticulum Ca release and Na-Ca exchanger current activation contribute to the sinoatrial node (SAN) automaticity. These findings suggest that SAN activity may share mechanisms that underlie both automaticity and triggered activity. The aim of this study is to test the hypothesis that spontaneous, nonvoltage gated, intracellular Ca (Cai) elevation may induce delayed afterdepolarization (DAD) in intact SAN during isoproterenol infusion. Methods and Results: We simultaneously mapped Cai and membrane potential in 31 isolated Langendorff-perfused canine right atriums (RA). Isoproterenol increased heart rate and late diastolic Cai elevation (LDCAE) of the superior SAN, leading to...

2011-01-01

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-d-aspartate receptors

British Library Electronic Table of Contents (United Kingdom)

The synthesis and structure-activity relationship analysis of a novel class of amide-based biaryl NR2B-selective NMDA receptor antagonists are presented. Some of the studied compounds are potent, selective, non-competitive, and voltage-independent antagonists of NR2B-containing NMDA receptors. Like the founding member of this class of antagonists (ifenprodil), several interesting compounds of the series bind to the amino terminal domain of the NR2B subunit to inhibit function. Analogue potency is modulated by linker length, flexibility, and hydrogen bonding opportunities. However, unlike previously described classes of NR2B-selective NMDA antagonists that exhibit off-target activity at a variety of monoamine receptors, the compounds described herein show much diminished effects against the...

2009-01-01

Radioiodinated phenoxyacetic acid derivatives as potential brain imaging agents, 2

Manufacturing method of metal-hydrogen alkali storage battery. Kinzoku-suiso alkali chikudenchi no seizo hoho

In developing new brain imaging agents for single photon emission computed tomography (SPECT), we synthesized eleven radioiodinated phenoxyacetic acid derivatives and investigated the relationship between the chemical structure and in vivo characteristics. Biodistribution studies in mice revealed high initial brain uptake for all the compounds. Blood radioactivity level depended markedly upon the chemical stability of the compound. The #alpha#,#alpha#-dimethylester derivative (1e), amide derivatives (2a-c) and diamine derivatives (3a, b, 4), which were stable to hydrolysis, showed low blood activity levels following i.v. administration. Disappearance of the ester and amide compounds from the brain was rapid. However, the diamine derivatives displayed improved retention in the brain. Compounds 3a and 4 possessed the best combination of high brain uptake and sufficient retention to be useful as potential brain imaging radiopharmaceuticals with ...

Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor

This invention is a manufacturing method of a metal-hydrogen alkali battery cell consisting of a positive electrode of metal oxides, alkaline electrolyte solution and a separator containing an amide-radical, wherein the above treating solution is aqueous solution of KOH (or NaOH) which is heated at least at 40 centigrade and the separator is first immersiion-treated and then water-washed and dried. The amide-radical-containing separaator uses a nylon non-woven fabrics. Average molecular weight of nylon 66 is 12,000 - 20,000. In this invention, in order to improve the storage ability and the cycle characteristics which are caused by corrosion of a separator which takes place in the cell after its assembly, the separator is immersed in a hot alkali in order to obtain a non-woven fabric of nylon 66 consisting of alkali-stable high molecular weight portion, which is assembled into a battery. By this, the dissolving of the non-woven fabric and the ...

1989-12-20

A fluorescent aminolipid from a green photosynthetic bacterium

Crystallography and computer modeling have been used to exploit a previously unexplored channel in the glucocorticoid receptor (GR). Highly potent, nonsteroidal indazole amides showing excellent complementarity to the channel were designed with the assistance of the computational technique AlleGrow. The accuracy of the design process was demonstrated through crystallographic structural determination of the GR ligand-binding domain-agonist complex of the D-prolinamide derivative 11. The utility of the channel was further exemplified through the design of a potent phenylindazole in which structural motifs, seen to interact with the traditional GR ligand pocket, were abandoned and replaced by interactions within the new channel. Occupation of the channel was confirmed with a second GR crystal structure of this truncated D-alaninamide derivative 13. Compound 11 displays properties compatible with development as an intranasal solution formulation, whereas oral ...

2010-09-17

British Library Electronic Table of Contents (United Kingdom)

A preliminary chemical characterization is presented of phosphate-free aminolipids isolation from Chlorobium limicola f. thiosulfatophilum. The lipid contains no phosphorus, glycerol, sugar, ornithine, or lysine. Ultraviolet absorption and fluorescence spectra indicate that the amino moiety of the lipid is an aromatic heterocyclic compound. Infrared spectra indicate that the lipid is a secondary or tertiary amide, and gas chromatograhic analysis of the hydrolyzed lipid shows that for each 1100 g of lipid, 1 mol of myristic acid (C/sub 14:0/) is linked in an amide bond. Acid hydrolysis of the lipid yields two fluorescent substances, A (ninhydrine positive) and B (negative), in addition to myristic acid. Proton nuclear magnetic resonance (NMR) studies indicate that substance A contains a butyl groups attached to a conjugated ring carbon, two equivalent ethyl groups attached to one or two nitrogen atoms, and two downfield protons (8.4 ppm), ...

1983-04-12

Cleavable surfactants

The review covers the development within the field of cleavable surfactants since 2003. Cleavable surfactants are amphiphiles in which a weak linkage has been deliberately inserted, normally, but not always, between the hydrophobic tail and the polar headgroup. Alkali labile linkages that have been used for the purpose include normal ester bonds, betaine esters, and carbonates. Ketals and ortho esters are example of bonds that are susceptible to acid hydrolysis. Several investigations deal with cationic ester-containing surfactants, both monomeric and dimeric species, the latter being gemini surfactants. Ester, amide and carbonate containing surfactants have been investigated with respect to enzyme catalyzed hydrolysis. The main incentive for the development of novel cleavable surfactants ...

2007-01-01

Ionizing radiation target groups of band 3 inserted into egg lecithin liposomes as determined by Raman spectroscopy

Ionizing radiation target groups of band 3 inserted into egg lecithin liposomes as determined by Raman spectroscopy

The purified integral membrane protein, band 3, from human erythrocytes was inserted into egg lecithin liposomes. The insertion of band 3 was determined from thermal transition data from the analysis of the C-H stretching region bands recorded at temperatures from 25 to -22[sup o]C. Raman spectra show that band 3 considerably broadens and lowers the thermal transition of egg lecithin liposomes, suggesting the insertion of band 3. The band 3-inserted liposomes were irradiated with gamma-rays (40 Gy) and the radiation target groups were determined by the analysis of the structural sensitive Raman bands in the 1600-1700 cm[sup -1] (amide I), 1200-1300 cm[sup -1] (amide III) and 550-1030 cm[sup -1] (side chain amino groups) regions. The radiation-sensitive groups as identified from Raman spectra in the region 550-1030 cm[sup -1] are tyrosines and cysteines. The radiation-induced changes in the secondary structure were determined from ...

1993-03-01

Visualization study on the static flow field around a straight-bladed vertical axis wind turbine

The purified integral membrane protein, band 3, from human erythrocytes was inserted into egg lecithin liposomes. The insertion of band 3 was determined from thermal transition data from the analysis of the C-H stretching region bands recorded at temperatures from 25 to -22"oC. Raman spectra show that band 3 considerably broadens and lowers the thermal transition of egg lecithin liposomes, suggesting the insertion of band 3. The band 3-inserted liposomes were irradiated with gamma-rays (40 Gy) and the radiation target groups were determined by the analysis of the structural sensitive Raman bands in the 1600-1700 cm"-"1 (amide I), 1200-1300 cm"-"1 (amide III) and 550-1030 cm"-"1 (side chain amino groups) regions. The radiation-sensitive groups as identified from Raman spectra in the region 550-1030 cm"-"1 are tyrosines and cysteines. The radiation-induced changes in the secondary structure were determined from amide I and ...

1 2 3 4

Interaction of periodic and iodic acids with propyoneamide in aqueous solutions

Visual experiments based on the smoke wire way were carried out on a small model of Straight-blade Vertical Axis Wind Turbine (SB-VAWT) to invest the relationship between the static flow field characteristics and the rotor azimuth angle. The test rotor had 3 blades with NACA0018 aerofoil. The rotor diameter and blade chord were 0.3m and 0.07m, respectively. Visual photos of the static flow path lines in and around the rotor were obtained at every 5 degrees of the azimuth angle. Further, numerical computations of the static flow filed were also carried out for comparison with the same situation as the visual tests and the static torques at different azimuth angles were calculated. According to the results of visual tests and computations, the dependence of the starting performance on the azimuth angle was discussed. The solidity is an important factor affecting the starting performance of the SB-VAWT.

2009-12-01

Inhibition of barium sulfate deposition by polycarboxylates of various molecular structures

Interaction of periodic and iodic acids with propyoneamide in aqueous solutions at 25 deg C has been studied. In the system iodic acid-propyoneamide-water formation of two compounds of the composition 6C_2H_5CONH_2#centre dot#HIO_3 and C_5H_5CONH_2#centre dot#HIO_3 is ascertained, for which concentrational boundaries of formation, density, melting points are determined. The system periodic acid-propyoneamide-water is referred to the simple eutonic type. By the method of IR spectroscopy it has been shown that oxygen atom of amide carbonyl group is the centre of propyoneamide protonation by iodic acid.

Immunofluorescence analysis of the internal brain anatomy of Nereis diversicolor (Polychaeta, Annelida)

To establish a relationship between the molecular structure of polycarboxylates and their growth-retarding influence on barium sulfate, seeded-suspension-growth experiments were performed at various inhibitor concentrations and pH values. Two types of polycarboxylates with a molecular structure based on their polyacrylic or maleic acid were studied. The molecular structure of these compounds were varied by particle substitution with monomers containing hydroxyl, amide, and sulfonic acid, as well as hydrophobic groups. Hydrophobic groups are detrimental to good inhibitor performance, whereas the introduction of OH, NH {sub 2}, or SO {sub 3} H groups presents opportunities to enhance the inhibitor effectiveness. The sequence in performance of the compounds on barium sulfate was compared with the sequence formerly obtained for calcium sulfate dihydrate.

1990-02-01

British Library Electronic Table of Contents (United Kingdom)

Comparative analyses of neuroanatomical characters can make valuable contributions to the inference of phylogenetic relationships. Whereas investigations in this field are numerous for arthropods, in-depth studies on other protostomes are sparse. Here, we provide a survey of the internal neuroarchitecture of the brain of the aciculate ragworm Nereis diversicolor (Polychaeta, Annelida). Descriptions are based on confocal laser scanning microscope analyses of brain sections labeled with the nuclear marker DAPI and antibodies raised against FMRF-amide, serotonin, and histamine. Autofluorescence of the nervous tissue has been utilized to further elucidate the anatomical structures of the brain. The architecture of two major brain compartments, i.e., the paired mushroom bodies and the central o...

2008-01-01

Chemical sensors based on surface-confined dendrimers

Chemical and physical change of packaging materials for food by gamma-ray irradiation

The use of dendrimers for preparing chemically sensitive interfaces for detecting volatile organic compounds (VOCs) using surface acoustic wave (SAW) device transducers is described. Specifically, the synthesis of the dendrimers and the means by which they are affixed to SAW devices is discussed, followed by a detailed spectroscopic analysis of the surface-confined dendrimers and a discussion of their interaction with different VOCs. Most of these preliminary experiments focus on dendrimer surface modification using benzoylchloride, which leads to phenyl terminal groups linked to the dendrimer via amide groups. The results of this study lead us to conclude that dendrimers: (1) provide general specificity towards classes of functional groups and are therefore suitable for array-based sensing schemes; (2) are intermediate in structure between monolayers and polymers and exhibit the desirable properties of both; (3) can be straightforwardly attached to the surfaces of ...

1997-10-01

Adversarial Science: Conflict Resolution and Scientific Review in British Columbia's Central Coast

Recently, foods are often exposed to radiation under packed states with various wrapping materials. In this study, the effects of #gamma#-ray radiation were investigated on the additives in wrapping materials on the market. 10 - 50 kGy #gamma# radiation was irradiated to samples under sealed condition in a glass-ware. Polyethylene bag and wrapping film, polypropylene wrapping film, cup and sheet, and polystyrene cup were used as samples. And the additives in these materials were analyzed by GC/MS to evaluate the radiation effects on them. The irradiation was found to induce rapid degradation of antioxidants, especially, Irgafos 168. Some fatty acid amides used as a lubricant and a plasticizer, DBP were also reduced, but not aliphatic hydrocarbons. However, all polystyrene products used in this study included no additives. The contents of styrene dimer and trimer in those wrapping materials were not changed by #gamma#-irradiation. (M.N.)

1999-02-01

British Library Electronic Table of Contents (United Kingdom)

Science plays paradoxical roles in environmental planning. As a process for generating and adapting knowledge of the biophysical environment to human use, it is essential to achieving sustainability. As the socially contested evaluation of competing claims to truth, however, adversarial science often becomes the focus of conflict in the planning process. British Columbia's Central Coast Land and Resource Management Plan (CCLRMP) planning process took place amid industrial restructuring, market campaigns, and scientific disputes over the conservation of the world's largest remaining temperate rainforest. This article shows how adversarial science set the terms of the policy debate, as well as the means for compromise. A multisector interdisciplinary information team played a key role in arr...

2011-01-01

Study of an industrial process for the synthesis of high molar mass ethylene oxide-propylene oxide copolymers usable as extrusible electrolyte; Etude d`un procede industriel de synthese de copolymeres oxyde d`ethylene-oxyde de propylene de hautes masses molaires utilisables comme electrolyte extrudable

NMR of a synthetic peptide spanning the triphosphate binding site of adenosine 5'-triphosphate in actin

The aim of this work is to develop an industrial process for the synthesis of an extrusible electrolyte polymer for lithium batteries. From literature data and precise specifications the high molar mass EO/OP copolymers synthesis by coordinative catalysis has been studied in order to reach a high productivity and to minimize the treatment steps. Two catalytic systems have been studied: the aluminium alkoxide-based Vandenberg-type catalysis and the calcium alcoholate amides catalysis. The first catalysis performed in solution gives excellent results. Its adaptation to silicon supported catalysis leads to a directly usable polymer in suspension but the productivity falls down and remains to be optimized. The calcium amide catalysis in heptane suspension generates acceptable productivities but also a too high proportion of low molar masses. Various approaches have been studied to minimize this proportion due to the presence of secondary sites that ...

1996-12-31

Effects of chronic swimming training on cardiac sarcolemmal function and composition.

The amino acid residues 114-118 in actin were found to be implicated strongly in the binding of nucleotide, and as would be expected for such an important binding site, they are located in a completely conserved region of the actin sequence. A 19-residue peptide with the actin sequence 106-124 was synthesized in order to span the putative triphosphate binding site. Proton NMR spectra of the actin peptide 114-118 in the presence and absence of ATP indicated that Arg-116 and Lys-118 are particularly involved in binding ATP. A strong binding of ATP to the peptide 106-124 also was measured. Tripolyphosphate bound to the peptide 106-124 somewhat more weakly than ATP. Binding involved residues 115-118 and 121-124, indicating the presence of a reverse turn between these segments. Proton resonances were assigned by using two-dimensional double quantum correlated spectroscopy, one-dimensional spin decoupling techniques, one-dimensional nuclear Overhauser enhancement difference spectroscopy, and ...

1987-03-10

Aerodynamic design of a midsized vertical-axis wind turbine using natural laminar-flow blade elements

Cardiac contractile function is dependent on the integrity and function of the sarcolemmal membrane. Swimming exercise training is known to increase cardiac contractile performance. The purpose of the present study was to examine whether a swimming exercise program would alter sarcolemmal enzyme activity, ion flux, and composition in rat hearts. After approximately 11 wk of exercise training, cardiac myosin and actomyosin Ca2+-adenosinetriphosphatase (ATPase) activity was significantly higher in exercised rat hearts than in sedentary control rat hearts. Glycogen content was increased in plantaris and gastrocnemius muscles from exercised animals as was succinic dehydrogenase activity in gastrocnemius muscle of exercised rats in comparison to sedentary rat preparations. Sarcolemmal vesicles were isolated from hearts of exercise-trained and control rats. Sarcolemmal Na+-K+-ATPase and K+-p-nitrophenylphosphatase activities, Na+-Ca2+ exchange, and passive Ca2+ binding ...

1989-04-01

Radiation resistance of nylon. [Gamma radiation

Natural laminar-flow (NLF) airfoils are those which can achieve significant extents of laminar flow (greater than or equal to 30% chord) solely through favorable pressure gradients. Studies have shown that vertical-axis wind turbines (VAWTs) using NLF sections as blade elements have the potential of producing energy at a significantly lower cost (approx. =20%) than turbines of current design. Sandia National Laboratories (SNL) is now in the process of procuring a blade set for its 17-m-diameter research turbine which will use NLF sections as blade elements. This paper describes the design of this blade set. The blade set design began with the definition of a family of three approximately 50% chord NLF sections (15, 18, and 21% t/c). These definitions involved numerically establishing airfoil contours giving section characteristics anticipated to be favorable in the VAWT context and then screening these using a VAWT performance model. Field tests of the 15 and 18% t/c sections as ...

1983-01-01

Processing technology for heat resisting resin suitable for small and high performance products. ; Semiaromatic polyamide applicable to regular injection molding. Kogata-koseinoka wo jitsugensuru tainetsu jushi no kako gijutsu. ; Tsujo no shashutsu seikei ga dekiru han hokozoku poriamido

Various nylons including nylon 6, nylon 66, nylon 610 and nylon 12 in the forms of fiber and film were irradiated with the gamma-ray from Co-60 at the dose rate of 0.12 Mrad/hr in the atmosphere of oxygen at 7 kg/cm/sup 2/ and at the room temperature. The irradiation in vacuum on the same specimens was performed at 0.5 Mrad/hr. The tensile properties and the gel fraction of the irradiated nylon samples were measured, and the radiation resistance of the nylons against the irradiation at low dose rate was estimated. From the experimental results, it became clear that in the case of irradiation in vacuum, all the nylons were durable to the irradiation of 250 Mrad or more, and nylon 6 was more durable than nylon 12, and in the case of irradiation in pressurized oxygen, the radiation resistance of the nylons decreased to one-tenth as compared with that in vacuum, and contrary to that in vacuum, nylon 12 was superior to nylon 6, while nylon 610 was intermediate. From these results, it was ...

1983-12-01

MWCNT-OH adsorbed electrospun nylon 6,6 nanofibers chemiresistor and their application in low molecular weight alcohol vapours sensing

Products having balanced melting point and decomposition temperature have been developed by employing nylon 6T fundamental molecular structure and selected copolymer components, Arlen being one of the products. It has heat resistance as good as that of super-engineering plastics, low water absorption, and excellent cost-performance which can be used for normal injection molding machines. The unit price per kilogram is low when its high heat resistance is taken into consideration. The coefficient of water absorption is as low as about 1/3 of that of nylon 66, and it can be considered to be a low water absorbing amide. The molding temperature is from 320[degree]C to 350[degree]C, the decomposition temperature is 395[degree]C at 2% weight decreasing temperature, and normal injection molding can be employed. It has excellent soldering resistance, high temperature rigidity, dimensional stability, water absorbing coefficient, as well as good chemical resistance and ...

1994-05-01

British Library Electronic Table of Contents (United Kingdom)

Herein, we fabricated MWCNT-OH adsorbed electrospun nylon 6,6 nanofibers by electrospinning and dip coating method. The amount of MWCNT-OH adsorbed to the pure electrospun nylon 6,6 nanofibers was 0.056wt%. The electrical conductivity of MWCNT-OH adsorbed electrospun nylon 6,6 nanofibers was 5.24x10^-^3Scm^-^1. We also investigated the sensing properties of MWCNT-OH adsorbed electrospun nylon 6,6 nanofibers by measuring its response upon exposure to low molecular weight alcohol vapours such as methanol, ethanol, 1-propanol, and 1-butanol. The changes of the electrical resistance of MWCNT-OH adsorbed electrospun nylon 6,6 nanofibers were demonstrated on the basis of hydrogen bonds among the alcohol vapours and hydroxyl groups (-OH) on MWCNT-OH, and amide groups (-NHCO-) in nylon 6,6. The fa...

2010-01-01

Interaction of bovine serum albumin with some novel PEG-containing diblock copolymers

British Library Electronic Table of Contents (United Kingdom)

A comparative study on the interaction of different PEG-containing diblock copolymers including SA400, SA600, SA1500 and OA1500 (stearyl and oleyl esters of polyethylene glycol with 400, 600 and 1500 molecular weights, respectively) with bovine serum albumin (BSA) was carried out using isothermal titration calorimetry (ITC), attenuated total reflectance Fourier transform infrared (ATR-FTIR), circular dichroism (CD), and fluorescence spectroscopies. ITC data show that SA400, SA600, SA1500 and OA1500 bind to BSA, with association constants of (14.5, 3.16, 50.7 and 17.6)x103M-1, respectively. Results also show that the binding is enthalpically driven, disfavored by conformational entropy. Quantitative analysis of the FTIR absorbance spectra at amide Iprime (1600-1700cm-1) as well as far UV ci...

2008-01-01

Higher Education in East Asia and Singapore: Rise of the Confucian Model

Gelatin ablation wavelength dependency in the range of 5.6-6.7 #mu#m using a mid-infrared Free Electron Laser

The paper reviews Asia-Pacific higher education and university research, focusing principally on the "Confucian" education nations Japan, Korea, China, Hong Kong China, Taiwan, Singapore and Vietnam. Except for Vietnam, these systems exhibit a special developmental dynamism--still playing out everywhere except Japan--and have created a distinctive model of higher education more effective in some respects than systems in North America, the English-speaking world and Europe where the modern university was incubated. The Confucian Model rests on four interdependent elements: (1) strong nation-state shaping of structures, funding and priorities; (2) a tendency to universal tertiary participation, partly financed by growing levels of household funding of tuition, sustained by a private duty, grounded in Confucian values, to invest in education; (3) "one chance" national examinations that mediate social competition and university hierarchy and focus family commitments to education; (4) ...

2011-05-01

Dendroaspis natriuretic peptide is the most potent natriuretic peptide to cause relaxation of lower esophageal sphincter

Efficient and precise ablation of soft tissue is needed for non-invasive dermatological and corneal surgeries. Previous research has revealed that smooth and efficient cutting of certain soft tissues and gelatin is possible using a Free Electron Laser (FEL) with a wavelength of #lambda#=6.45 #mu#m, tuned to the amide-II band of protein. Gelatin ablation experiments have been carried out using a mid-infrared FEL within the waveband #lambda#=5.6-6.7 #mu#m by changing the primary absorbers such as water (#lambda#=6.1 #mu#m) and protein (#lambda#=6.45 #mu#m). The gelatin with 80 wt% water was efficiently ablated by FEL irradiation with the waveband #lambda#=#approx#5.95-6.19 #mu#m. On the other hand, using irradiation within #lambda#=#approx#6.4-6.6 #mu#m, many small bubbles were observed in the irradiated volume, and the gelatin was not ablated but significantly melted. Thus, it was found that the most effective wavelength was #approx#6.1 #mu#m, not #approx#6.45 ...

2003-07-11

British Library Electronic Table of Contents (United Kingdom)

Atrial natriuretic peptide (ANP) causes relaxation in the opossum lower esophageal sphincter. The effects of dendroaspis natriuretic peptide (DNP) and other natriuretic peptides in the lower esophageal sphincter were not known. We measured the relaxation of transverse strips from the guinea pig lower esophageal sphincter caused by DNP, ANP, brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and a natriuretic peptide receptor-C agonist des[Gln^1^8, Ser^1^9, Gly^2^0, Leu^2^1, Gly^2^2]ANP(4-23) amide (cANF(4-23)) in vitro. In resting strips of the guinea pig lower esophageal sphincter DNP and BNP caused marked relaxations. Furthermore, in both sarafotoxin S6c and carbachol-contracted lower esophageal sphincter strips, DNP caused marked and BNP caused moderate, concentration-de...

2011-01-01

Coal compilation project - Moberly Creek NTS 83E/9

Synthesis of 4,5,6,7 and 2,4,5,6,7 deuterium-labeled indole-3-acetic acid for use in mass spectrometric assays

The primary purpose of the pilot Coal Compilation Project is to provide coal resource maps to stimulate and support industry exploration programs and to assist government in matters of resource management. An essential feature of the program is the use of cost effective Geoscience Information System (GSIS) technology that allows the database and various thematic maps to be analysed, updated and displayed with complete flexibility at any scale. This report describes the main features (geology, resource management, exploration history, coal occurrences etc.) of the study area, mapsheet NTS 83E/9 (Moberly Creek), and includes a copy of the 1:50,000 scale map produced. The study area is located in West-central Alberta and contains coal measures deposited amid thick successions of sandstones, siltstones, shales and conglomerates. These coal-bearing sequences are part of the Luscar Group, Upper Cretaceous Brazeau Formation and Paleocene Coalspur Formations. Coal seams ...

1990-01-01

Synthesis and characterization of ["1"2"5I]-N-(N-benzylpiperidin-4-YL)-4-iodobenz amide, a potential high affinity sigma ligand for imaging breast cancer

Syntheses are described for tetra and pentadeutero indole-3-acetic acid (IAA) labeled in positions 4,5,6,7 or 2,4,5,6,7 of the indole moiety. Polydeuterated IAA is proposed as an internal standard for gas chromatographic-mass spectrometric analysis of IAA by selected ion monitoring. Nanogram amounts of IAA may be assayed by monitoring the base peak of IAA at m/z = 130 (134 for d/sub 4/-IAA) and the molecular ion of the methyl ester of IAA at 189 (193 for d/sub 4/-IAA). Deuterium in positions 4,5,6, and 7 and, to only a slightly lesser extent, that in position 2 of IAA is retained during alkali treatment, thus permitting use of these compounds as internal standards for assay of IAA released by alkaline hydrolysis of ester and amide conjugates. The use of polydeutero internal standards separates the standards from the isotope cluster caused by the normal abundance of heavy isotopes and also permits use of reduced mass resolution, thus leading to a 10-fold increase in ...

1980-10-01

1 2 3 4

Propanil-induced methemoglobinemia and hemoglobin binding in the rat

Three regio-isomers of N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, IBP, were prepared and evaluated for their sigma affinities. All three isomers (2, 3, and 4-substituted) showed high affinities for sigma-1 receptors in guinea pig brain membranes (Ki - 1.64 nM, 3.02 nM, 1.70 nM respectively) against ["3H]-(+)-pentazocine, a sigma-1 selective ligand. 2-IBP and 4-IBP showed modest affinities for sigma-2 sites in rat liver (Ki = 29.6 nM. 25.2 nM respectively) against ["3H]DTG in the presence of dextrallorphan to mask sigma-1 sites. The homologous competition binding studies of 4-["1"2"5I]BP in MCF-7 human breast tumor cells showed high affinity dose-dependent binding. Competition binding studies with haloperidol and DTG also showed a high affinity binding (Ki = 4.6 nM, 60 nM respectively), demonstrating the sigma specificity. The saturation binding (Scatchard analysis) of ["3H]DTG with MCF-7 cell membrane preparations gave Kd of 24.54 nM and a Bmax of 2071 fmol/mg protein. These results ...

1994-08-21

Platelet receptor recognition domain on the. gamma. chain of human fibrinogen and its synthetic peptide analogues

Administration of [ring-U-14C]propanil (3,4-dichloropropionanilide) to male Sprague-Dawley rats (30, 100, and 300 mg/kg, ip) increased the formation of methemoglobin at the two highest doses. Following a propanil dose of 100 mg/kg, methemoglobin formation attained a maximum level of 5% by 1.5 hr and declined to normal levels (approximately 2.5%) by 12 hr. Hemoglobin binding attained a maximum level of 50 pmol/mg protein by 12 hr, and remained constant for 24 hr. Following a propanil dose of 300 mg/kg, methemoglobin formation attained a maximum level of 24% by 4.5 hr, and declined to a level of 5% by 24 hr. Hemoglobin binding attained a maximum level of 425 pmol/mg protein by 12 hr, and remained constant for 24 hr. Hemoglobin binding was also detected at the lowest propanil dose (10 pmol/mg protein) even though methemoglobin formation was not observed. HPLC analysis of alkaline-treated hemoglobin from propanil-treated rats indicated the presence of one radiolabeled compound with the ...

Coal compilation project - Pierre Greys Lakes NTS 83E/15

The authors have shown previously that the domain recognizing receptors on activated human platelets is located on the human fibrinogen {gamma} chain between residues 400 and 411. To study the correlation between the structure of this segment of the {gamma} chain and its reactivity toward receptors on ADP-activated human platelets, they designed a series of analogues containing replacements at 9 out of 12 positions. A double substitution of the normal His{sup 400}-His{sup 401} sequence by Ala-Ala reduced the inhibitory potency of the dodecapeptide 3-fold. When Lys{sup 406} was replaced by Arg, the inhibitory potency of the dodecapeptide decreased 15 times. On the other hand, substitution of Ala{sup 408} with Arg increased the inhibitory potency of the dodecapeptide 6-fold. A drastic decrease in the reactivity of the dodecapeptide toward platelet receptors was observed when Val{sup 411} was replaced by leucine or cysteine or tyrosine. A 3-fold decrease in reactivity was noted when ...

1989-04-04