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Melanoma  

Medline Plus

Full Text Available ... skin. When melanoma starts in the skin, the disease is called cutaneous melanoma. Melanoma can also occur ... ew tumor are still melanoma cells, and the disease is called metastatic melanoma. Melanoma can occur on ...

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Melanoma  

Medline Plus

Full Text Available Melanoma Introduction Melanoma is the most serious cancer of the skin. Melanoma affects thousands of people every ... causes damage to the chromosomes, leading to cancer. Melanoma Melanoma occurs when the pigment cells, the melanocytes, ...

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Melanoma  

Science.gov (United States)

Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color, or feel of a mole. Most melanomas have a black or black-blue area. Melanoma ...

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Melanoma  

Medline Plus

Full Text Available Melanoma Introduction Melanoma is the most serious cancer of the skin. Melanoma affects thousands of people every year. If detected early, melanoma can be successfully treated by surgically removing it. This reference summary explains the ...

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Melanoma  

Medline Plus

Full Text Available ... in the skin. When melanoma starts in the skin, the disease is called cutaneous melanoma. Melanoma can also occur ... help prevent and reduce the risk of melanoma caused by UV radiation, people should avoid exposure to ...

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Melanoma  

Medline Plus

Full Text Available ... in the skin. When melanoma starts in the skin, the disease is called cutaneous melanoma. Melanoma can also occur ... ew tumor are still melanoma cells, and the disease is called metastatic melanoma. Melanoma can occur on any skin surface. In men, it is often found on ...

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Melanoma  

Science.gov (United States)

... melanomas. There are four major types of melanoma: Superficial spreading melanoma is the most common type. It ... Avoid surfaces that reflect light more, such as water, sand, concrete, and white-painted areas. Be extra ...

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Melanoma  

Medline Plus

Full Text Available ... of these methods. Biological Therapy (Interferon and Interleukin-2) Some patients with advanced melanoma may receive drug ... following are risk factors for melanoma: 1. Having 2 or more close relatives who have had melanoma ...

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Melanoma  

Medline Plus

Full Text Available ... black color or forming fine scales. In more advanced melanoma, the mole becomes thick, deep, hard, or lumpy. It may also itch, ooze, or bleed. Advanced melanomas do not usually cause pain. A skin ...

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Melanoma  

Medline Plus

Full Text Available ... existing mole. Most melanomas have a black or blue-black area. Most people have moles. Moles are ... present. Areas of white, gray, red, pink, or blue may also be seen. Diameter Melanomas are usually ...

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Melanoma  

Medline Plus

Full Text Available ... symmetry. In melanomas the two halves of the lesion do not usually look similar. Smooth Border Irregular ... X-rays; blood tests; and scans of the liver, bones, and brain. Stages of Melanoma: • Stage 0: ...

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Melanoma  

Medline Plus

Full Text Available ... sign of melanoma is a change in the size, shape, color, or feel of an existing mole. ... that have changes in symmetry, color, texture, and size. You are more likely to have melanoma if ...

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Melanoma  

Medline Plus

Full Text Available ... or more close relatives who have had melanoma 2. Having abnormal moles 3. Having had melanoma before 4. Having more than 50 moles 5. Having had one or more severe sunburns as ...

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Melanoma  

Medline Plus

Full Text Available ... a melanoma is not removed in an early stage, cancer cells may grow down into the skin, ... melanoma is found, the doctor will determine what stage the cancer is in before planning treatment. This ...

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Melanoma  

Medline Plus

Full Text Available ... radiation from the sun can cause melanoma. Artificial sources of UV radiation, such as sunlamps and tanning ... that have changes in symmetry, color, texture, and size. You are more likely to have melanoma if ...

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Melanoma  

Medline Plus

Full Text Available ... drying out. Sweat and sebum reach the skin's surface through tiny openings called pores. This document is ... metastatic melanoma. Melanoma can occur on any skin surface. In men, it is often found on the ...

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Melanoma  

Medline Plus

Full Text Available ... growth. It can also spread to the liver, brain, bones, and other organs. Treatment A treatment plan for melanoma depends on: • the location and thickness of the tumor • how deeply the melanoma has invaded the skin • ...

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Melanoma  

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Full Text Available ... p ages. Melanoma is one of the most common cancers in young adults. When melanoma spreads, cancer ... found when a pre-existing mole changes slightly. Common changes include changing to black color or forming ...

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Melanoma  

Medline Plus

Full Text Available ... change from one treatment to the next. Prevention & Risk Factors X Doctors believe that the increase in cases ... to have melanoma if any of the melanoma risk factors apply to you. The following are risk factors ...

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Melanoma  

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Full Text Available ... in outline. Uniform Color Shades of Different Colors Color The color of melanomas is uneven. Shades of black, brown, ... changes slightly. Common changes include changing to black color or forming fine scales. In more advanced melanoma, ...

 
 
 
 
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Melanoma  

Medline Plus

Full Text Available ... necessary. The doctor also does a careful physical exam and, depending on the thickness of the tumor, ... check your skin regularly and have regular skin exams by a doctor or nurse specialist. Summary Melanoma ...

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Melanoma  

Medline Plus

Full Text Available ... other parts of the body such as the liver, lungs, or brain. In such cases, the cancer ... X-rays; blood tests; and scans of the liver, bones, and brain. Stages of Melanoma: • Stage 0: ...

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Melanoma  

Medline Plus

Full Text Available ... occur as a result of exposure to infections, drugs, tobacco, chemicals, or other factors. In the case ... 2) Some patients with advanced melanoma may receive drug treatments that may improve the body’s natural defense ( ...

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Melanoma  

Medline Plus

Full Text Available ... Melanoma can be cured if detected early. Early detection involves regularly checking your body for skin growths that have changes in symmetry, color, texture, and size. You are ...

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Melanoma  

Medline Plus

Full Text Available ... of melanoma. It also discusses some prevention tips. Skin Anatomy The skin is the body's largest organ. It protects us ... fat, and produces vitamin D. Epidermis Dermis The skin has 2 main layers: the outer epidermis and ...

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Melanoma  

Medline Plus

Full Text Available ... decide to use one treatment method or a combination of methods. Surgery to remove a melanoma is ... as chemotherapy, biological therapy, radiation therapy, or a combination of these methods. Biological Therapy (Interferon and Interleukin- ...

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Melanoma  

Medline Plus

Full Text Available ... cancer has reached the lymph nodes, it may mean that cancer cells have spread to other parts ... Mole Asymmetry A melanoma is usually asymmetric, which means it is not usually perfectly round. The shape ...

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Melanoma  

Medline Plus

Full Text Available ... darken. The dermis contains blood vessels, lymphatic vessels, hair follicles, and glands. Some of these glands produce sweat, ... 2) Some patients with advanced melanoma may receive drug treatments that may improve the body’s natural defense ( ...

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Melanoma  

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Full Text Available ... The epidermis is mostly made up of flat, scale-like cells called squamous cells. Round cells, called ... include changing to black color or forming fine scales. In more advanced melanoma, the mole becomes thick, ...

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Melanoma  

Medline Plus

Full Text Available ... Punch biopsy: The doctor uses a sharp, hollow tool to remove a circle of tissue from the ... standard treatment for melanoma is surgery; in some cases, the doctor may also use chemotherapy, biological therapy, ...

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Melanoma  

Medline Plus

Full Text Available ... rays; blood tests; and scans of the liver, bones, and brain. Stages of Melanoma: • Stage 0: The ... It can also spread to the liver, brain, bones, and other organs. Treatment A treatment plan for ...

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Melanoma  

Medline Plus

Full Text Available ... melanoma may arise in the covering of the brains, meninges, the digestive tract, lymph nodes, or other ... the body such as the liver, lungs, or brain. In such cases, the cancer cells in the ...

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Melanoma  

Medline Plus

Full Text Available ... mole should be reported to a doctor or nurse right away. Diagnosis & Staging If the doctor suspects ... have regular skin exams by a doctor or nurse specialist. Summary Melanoma is a skin cancer where ...

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Melanoma  

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Full Text Available ... may change from one treatment to the next. Prevention & Risk Factors X Doctors believe that the increase ... Last reviewed: 07/07/2011 7 To help prevent and reduce the risk of melanoma caused by ...

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Melanoma  

Medline Plus

Full Text Available ... change from one treatment to the next. Prevention & Risk Factors X Doctors believe that the increase in ... also cause skin damage and probably an increased risk of melanoma. This document is for informational purposes ...

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Melanoma  

Medline Plus

Full Text Available ... The doctor may decide to use one treatment method or a combination of methods. Surgery to remove a melanoma is the standard ... body. In such cases, doctors may use other methods of treatment, such as chemotherapy, biological therapy, radiation ...

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Melanoma  

Medline Plus

Full Text Available ... advanced melanoma may receive drug treatments that may improve the body’s natural defense (immune system response) against cancer. These drugs commonly cause a rash or swelling. You may feel very tired and these drugs can cause a headache, muscle aches, a fever, or ...

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Melanoma  

Medline Plus

Full Text Available ... therapy, radiation therapy, or a combination of these methods. Biological Therapy (Interferon and Interleukin-2) Some patients with advanced melanoma may receive drug treatments that may improve the body’s natural defense (immune system response) against cancer. These drugs commonly cause a rash ...

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Cutaneous Melanoma  

Science.gov (United States)

Home Cancers Selected for Study Cutaneous Melanoma Cutaneous Melanoma Last Updated: February 22, 2012 What is melanoma? Melanoma is a cancer in the type of skin cells called melanocytes.  Melanocyes are the cells that produce melanin, which colors

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Melanoma: Signs and Symptoms  

Science.gov (United States)

... Diseases and treatments M - P Melanoma Signs, symptoms Melanoma: Signs and symptoms Anyone can get melanoma. It’s ... look for the ABCDEs of melanoma. ABCDEs of melanoma A = Asymmetry One half is unlike the other ...

 
 
 
 
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Oral Melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Melanoma is a malignant tumor that originates from melanocyte cells. Its oral type is rare. The goal of this investigation was to determine the prevalence of oral malignant melanoma in Iran, as determined by age, sex and location. This research reviewed 623 cases of oral and non-oral malignant melanoma in Immam-Khomeini hospital, Mearaj cancer institute and department of oral pathology of dental faculty, Tehran University of Medical Sciences in a period of 19 years from 1981-1999. The results showed that 54 cases of biopsy lesions were melanoma of oral cavity that included 7.8% of these lesions. The mean age incidence of oral melanoma was 55.5(between 26-86 years. The most prevalent sites were palate (37.1% and alveolar mucosa (20.4% and less common sites included floor of mouth. buccal mucosa and tongue.

A Forouzandeh

2002-02-01

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Oral Melanoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Melanoma is a malignant tumor that originates from melanocyte cells. Its oral type is rare. The goal of this investigation was to determine the prevalence of oral malignant melanoma in Iran, as determined by age, sex and location. This research reviewed 623 cases of oral and non-oral malignant melanoma in Immam-Khomeini hospital, Mearaj cancer institute and department of oral pathology of dental faculty, Tehran University of Medical Sciences in a period of 19 years from 1981-1999. The results...

Forouzandeh, A.; Rostamali, G.

2002-01-01

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What Does Melanoma Look Like?  

Science.gov (United States)

What Does Melanoma Look Like? Posted: 10/13/2011 Melanoma is a type of cancer that begins in melanocytes ( cells that ... melanoma is itchy, tender, or painful. Photos of Melanoma A large, asymmetrical melanoma with an uneven color ...

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Choroidal melanoma  

International Nuclear Information System (INIS)

Choroidal melanoma is the most frequent intraocular tumor in adults. Due to its anatomic location the diagnosis often should be made on the basis of clinical examination and ancillary diagnostic procedures. The choroid melanoma may appear as a visual disturbance, retinal detachment and decrease of visual acuity. The diagnostic methods of choice are: Ultrasonography, Doppler, Ophthalmoscopy and Fluorescein Angiography, Computed Tomography and Magnetic Resonance Imaging (MRI) and are very useful in evaluating extra ocular extension of the tumor, post treatment local recurrence and differential diagnosis. Ultrasound is the primary method of diagnosis and follow up when a conservative treatment has been used, showing changes in vascularity and echogenicity. Magnetic resonance imaging is very useful in melanotic melanomas because the paramagnetic properties of melanine. They appear as areas of moderately high T1 signal and proton weighted MRI greater than vitreous and hypointensity in T2. The proper interpretation of its clinical presentation and the early use of imaging diagnostic methods allow a correct therapeutic approach and avoid local and distant metastasis which decrease survival time in these patients. (author)

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Choroidal melanoma  

International Nuclear Information System (INIS)

A useful and practical guide is developed to better track to the uveal melanoma, due to its highly malignant character. Melanoma of the uveal tract (choroid, iris, ciliary body) has been the intraocular tumor most frequent in adults. The biopsy has been inaccessible, due to its location; therefore, the diagnostic should be based on clinical examination and the correct utilization of the diagnostic procedures (ultrasound, fluorescent angiography, computed axial tomography and magnetic resonance). The cases are diagnosed in the histological examination of the operatory piece post-enucleation for other causes. Epidemiological research has been key to determine the associated factors and better to understand the mechanisms of onset of the disease. Anatomopathological studies of choroidal melanoma have permitted to know the natural history of the disease. The decrease of the visual acuity, pain or inflammation are presented as a defect in the visual field. Different techniques to diagnose the disease are explained. Ultrasound in mode A and B, computed axial tomography and magnetic resonance are the diagnostic method of election. Ultrasound has been the primary method of diagnostic, giving the size and vascularisation, useful in tracking, when they are treated in shape conservatively, showing changes in echogenicity and less vascularisation as good response to treatment. The treatments of choroidal melanoma are specified. The correct interpretation of the clinical symptoms and early utilization of diagnostic imaging methods, have permitted to establish the adequate therapeutic and to avoid local and distant metastasis. The uveal melanoma, depending on their size and location, traditionally has been treated by enucleation. Data from the literature and authors, have promoted the conservation of the ocular globe, depending on the size of the tumor. Transpupillary thermotherapy has been an available alternative for small tumors in Costa Rica and level of social security. Patients have had the option to keep the ocular globe and even maintain good visual acuity with this therapy. Brachytherapy has been another alternative treatment in tumors of medium size, and can be performed in countries like Colombia and the United States

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Skin cancer and melanoma  

International Nuclear Information System (INIS)

In this chapter, the author discusses various types of non-melanoma malignant skin cancer, as well as malignant melanoma. Non-melanoma skin cancer, such as basal cell and squamous cell carcinomas, occasionally metastasize, but only late in the course of the disease. On the other hand, even relatively small primary melanomas tend to disseminate to regional lymph nodes and to distant sites. The author presents various treatment plans, including radiation therapy. Cutaneous melanomas have been considered relatively radioresistant. This is the rationale for the use of large fraction radiation therapy in the treatment of melanomas with the fraction sizes varying from 4--8 Gy

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Melanoma - neck (image)  

Science.gov (United States)

This melanoma on the neck is variously colored with a very darkly pigmented area found centrally. It has irregular ... be larger than 0.5 cm. Prognosis in melanoma is best defined by its depth on resection.

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Melanoma International Foundation  

Science.gov (United States)

... MD September 27, 2013 Our Awards Melanoma International Foundation Our Mission: To develop personalized strategies with patients ... state of Pennsylvania, certificate #29498 © 2013 Melanoma International Foundation. All Rights Reserved. Privacy Policy | Terms of Use ...

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Primary ovarian malignant melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

Kostov Miloš

2010-01-01

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Pedunculated malignant melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Pedunculated malignant melanoma is a rare occurrence. A 29 year old woman presented with a pedunculated malignant melanoma on a congenital melanocytic naevus with halo. Pedunculated malignant melanoma is known to have a high incidence of metastasis. The absence of metastasis and the presence of halo, in the case presented, suggests, that the body?s immunological process may have arrested the spread of the melanoma.

Bhat Ramesha

1994-01-01

51

General Information about Melanoma  

Science.gov (United States)

... inner layer). There are 3 types of skin cancer : Melanoma . Basal cell skin cancer . Squamous cell skin cancer . When melanoma ... skin cancer. (See the PDQ summary on Skin Cancer Treatment for more information on basal cell and squamous cell skin cancer.) Melanoma can occur ...

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Vaccine Therapy in Treating Patients With Stage IIC-IV Melanoma  

Science.gov (United States)

Ciliary Body and Choroid Melanoma, Medium/Large Size; Ciliary Body and Choroid Melanoma, Small Size; Extraocular Extension Melanoma; Iris Melanoma; Metastatic Intraocular Melanoma; Mucosal Melanoma; Recurrent Intraocular Melanoma; Recurrent Melanoma; Stage IIC Melanoma; Stage IIIA Intraocular Melanoma; Stage IIIA Melanoma; Stage IIIB Intraocular Melanoma; Stage IIIB Melanoma; Stage IIIC Intraocular Melanoma; Stage IIIC Melanoma; Stage IV Intraocular Melanoma; Stage IV Melanoma

2014-05-20

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Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma  

Science.gov (United States)

Acral Lentiginous Malignant Melanoma; Lentigo Maligna Malignant Melanoma; Nodular Malignant Melanoma; Recurrent Melanoma; Solar Radiation-related Skin Melanoma; Stage IV Melanoma; Superficial Spreading Malignant Melanoma

2014-06-09

54

Malignant melanoma - a warning  

International Nuclear Information System (INIS)

Incidence of malignant melonoma of the skin has risen rapidly during the last decades. Mortality rates are also rising, although not so much as incidence rates. There is strong evidence that exposure to sunlight is a major factor in the etiology of melanomas. There appears to be no direct cumulative dose-response relationship, except in the case of lentigo maligna melanoma. Episodes of sunburn among children and young individuals seem to be more important as an etiologic factor for melanoma than chronic exposure to the sun. Very high risk of melanoma exists in persons with dysplastic nevus syndrome. Persons with giant congenital nevi are also at increased risk. However, many melanomas arise de novo. The intension of the authors is to reduce mortality by screening families at risk, by early detection and treatment of melanomas, and by education. 15 refs., 2 tabs

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Quimiorresistencia del melanoma Chemoresistance to melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Varias estrategias terapéuticas como la cirugía, radioterapia y quimioterapia están siendo utilizadas para tratar el cáncer. Sin embargo, en el caso del melanoma solamente la cirugía en las etapas tempranas de la enfermedad (estadíos I-II puede ser curativa en una alta proporción de pacientes. El tratamiento quimioterápico con dacarbacina (DTIC así como combinaciones con cisplatino, vinblastina y carmustina resulta ineficaz para eliminar las células de melanoma, ya que sólo se alcanza una respuesta en alrededor del 10% de los pacientes sin prolongar la sobrevida. La quimiorresistencia puede deberse tanto a una falta de respuesta primaria del melanoma como al desarrollo de mecanismos de resistencia adquiridos por el tumor, comúnmente definidos como multi-resistencia a drogas (MDR. En este artículo se analizan los principales mecanismos responsables de dicha resistencia y cómo el conocimiento de los mismos es aplicado al desarrollo de nuevos agentes terapéuticos. Por último, se discuten las recientes estrategias que combinan la quimioterapia con la inmunoterapia (Bioquimioterapia para optimizar el tratamiento del melanoma metastásico.Several therapeutic strategies such as surgery, radiotherapy and chemotherapy are being used to treat cancer. However, in the case of melanomas, only surgery during the early stages (stages I-II of the disease can be curative in a high proportion of patients. Chemotherapy treatment with dacarbazine (DTIC as well as combinations with cisplatin, vinblastine and carmustine proves to be ineffective to eliminate melanoma cells, since only 10% of patients responded positively without prolonging survival. Chemoresistance can be caused by both a lack of primary response of the melanoma and the development of resistance mechanisms acquired by the tumor usually defined as multi-drug resistance (MDR.The most important mechanisms responsible for such resistance and how the knowledge of those mechanisms is applied to the development of new therapeutic agents are analyzed in this article. Finally, the latest strategies that combine chemotherapy and immunotherapy (Biochemotherapy to optimize the treatment of metastatic melanoma will be further discussed.

María Marcela Barrio

2009-09-01

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Primary malignant melanoma of prostate  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Primary genitourinary melanoma accounts for less than one per cent of all cases of melanoma. Most cases attributed to the prostate actually originate from the prostatic urethra. Due to its infrequency, primary malignant melanoma of the genitourinary tract presents a difficult diagnostic and management challenge. We report a case of primary malignant melanoma of the prostate found during transurethral resection of the prostate.

Doublali M; Chouaib A; Khallouk A; Tazi M; El Fassi M; Farih My; Elfatmi H; Bendahou M; Benlemlih A; Lamarti O

2010-01-01

57

Interleukin-6 and melanoma  

DEFF Research Database (Denmark)

Interleukin-6 (IL-6) is a pleiotropic immunomodulatory cytokine produced by various types of cells, including melanoma cells. IL-6 plays a major role in the pathogenesis and development of malignancies. It promotes tumour growth by inhibition of apoptosis and induces tumour angiogenesis. IL-6 is deregulated in many types of cancers, and increased serum concentration of IL-6 has been correlated with a worse prognosis in patients with different cancers, including melanoma. Several serum cytokines including IL-6 play an important role in the development and progression of melanoma; however, the specific biological functions of IL-6 in progression of melanoma are unknown. In this review, we present studies on cell cultures and mouse models and summarize published clinical studies on IL-6 and melanoma.

Hoejberg, Lise; Bastholt, Lars

2012-01-01

58

Main roads to melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract The characterization of the molecular mechanisms involved in development and progression of melanoma could be helpful to identify the molecular profiles underlying aggressiveness, clinical behavior, and response to therapy as well as to better classify the subsets of melanoma patients with different prognosis and/or clinical outcome. Actually, some aspects regarding the main molecular changes responsible for the onset as well as the progression of melanoma toward a more aggressive phenotype have been described. Genes and molecules which control either cell proliferation, apoptosis, or cell senescence have been implicated. Here we provided an overview of the main molecular changes underlying the pathogenesis of melanoma. All evidence clearly indicates the existence of a complex molecular machinery that provides checks and balances in normal melanocytes. Progression from normal melanocytes to malignant metastatic cells in melanoma patients is the result of a combination of down- or up-regulation of various effectors acting on different molecular pathways.

Sini Maria

2009-10-01

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Melanoma de pene / Melanoma of the penis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Presentamos un caso de melanoma maligno de pene. Su rareza inferior al 1% de las neoplasias malignas de genitales masculinos, la ausencia de protocolos estandarizados como para otras neoplasias, nos impulsan su publicación. [...] Abstract in english We present a case of penis’ malignant melanoma. The inferior rarity to 1% of masculine genital’s malignant neoplasms, the absense of standardised protocols as for other neoplasm’s, impel us to its publication. [...

M.L., Millán Sagaste; L.A., Asensio Lahoz; J.M., Monge Mirallas; A., Pérez Martín; M.J., Fernández Lerones; A.J., Guezmes Domingo; O., Acinas García.

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A disguised Melanoma Melanoma disfrazado Um Melanoma “mascarado”  

Directory of Open Access Journals (Sweden)

Full Text Available

Melanoma is a tumor that develops as a result of the malignant transformation of the melanocytes. There is a worldwide estimate of 132,000 new cases per year. This case study presents a 70-year-old male person with history of Diabetes Mellitus type 2 for 10 years and extensive psoriasis vulgaris for 6 years. The patient developed an ulcerated lesion in the plantar region of the right foot in one-year time period. The histological examination revealed an ulcerated malignant melanoma, Clark level V, 5.6 mm thick (Breslow. The lesion was surgically removed and the sentinel lymph node biopsy was negative. Initial conclusions revealed an advanced state of evolution of the primary tumor (TNM IIC. CAT scan detected gastric metastasis, reclassifying the illness as a TNM IV stage. Malignant melanoma may be difficult to diagnose, as it was possible to observe in this case study, where a foot ulcer was late diagnosed, delaying the diagnosis of a severe neoplasia with high mortality rate.

El melanoma es un tumor que se desarrolla como resultado de la transformación maligna de los melanocitos, estimándose su incidencia global en 132,000 casos/año. Este informe presenta a un paciente de sexo masculino de 70 años, con antecedentes de Diabetes Mellitus tipo 2 desde hace diez años y psoriasis vulgar extensa desde hace seis años. En aproximadamente un año el paciente desarrolló una lesión ulcerada en la región plantar del pie derecho, el examen histológico reveló un melanoma maligno, ulcerado, nivel V de Clark, de 5.6 mm de espesor (Breslow. Después de una escisión quirúrgica de la lesión, se realizó una biopsia de ganglio centinela que fue negativa. Las conclusiones iniciales revelaron una evolución avanzada del tumor primario (TNM IIC. Exámenes radiológicos detectaron una metástasis gástrica, reclasificando la enfermedad en una etapa TNM IV. El melanoma maligno puede ser de difícil diagnóstico, como se puede ver en este caso en que una úlcera en la planta del pie fue diagnosticada muy tarde, atrasando el diagnóstico de una neoplasia grave y de elevada tasa de mortalidad.

O melanoma é um tumor que se desenvolve como resultado da transformação maligna dos melanócitos, estimando-se a sua incidência global em 132.000 casos/ano. Este relato de caso reporta-se a um doente do sexo masculino com 70 anos, história de Diabetes Mellitus tipo 2 há dez anos e psoríase vulgar extensa há seis anos. Em aproximadamente um ano, este desenvolveu lesão ulcerada da região plantar do pé direito, que ao exame histológico revelou melanoma maligno, ulcerado, nível V de Clark, com 5,6 mm de espessura (Breslow. Foi submetido à exérese cirúrgica da lesão e biópsia de gânglio sentinela que foi negativa. O estadiamento inicial revelou evolução avançada do tumor primário (TNM IIC. Exames imagiológicos detetaram metastização gástrica, reclassificando a doença num estádio TNM IV. O melanoma maligno pode ser de difícil diagnóstico como se pode constatar neste caso em que uma ulceração plantar foi avaliada tardiamente, atrasando o diagnóstico de uma neoplasia grave e com elevada taxa de mortalidade.

Cláudia Sofia Rego

2012-08-01

 
 
 
 
61

Proteomics in uveal melanoma.  

LENUS (Irish Health Repository)

Uveal melanoma is the most common primary intraocular malignancy in adults, with an incidence of 5-7 per million per year. It is associated with the development of metastasis in about 50% of cases, and 40% of patients with uveal melanoma die of metastatic disease despite successful treatment of the primary tumour. The survival rates at 5, 10 and 15 years are 65%, 50% and 45% respectively. Unlike progress made in many other areas of cancer, uveal melanoma is still poorly understood and survival rates have remained similar over the past 25 years. Recently, advances made in molecular genetics have improved our understanding of this disease and stratification of patients into low risk and high risk for developing metastasis. However, only a limited number of studies have been performed using proteomic methods. This review will give an overview of various proteomic technologies currently employed in life sciences research, and discuss proteomic studies of uveal melanoma.

Ramasamy, Pathma

2014-01-01

62

Disseminated malignant melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available A 25-year-old man had multiple asymptomatic, nodular lesions on the trunk, extremities and the face for 3 months. He also had left facial palsy with severe headache and vomiting. There were no other systemic or constitutional symptoms. Skin biopsy from a nodular lesion showed features of malignant melanoma, confirmed by Fontana Masson and S-100 protein staining. A diagnosis of disseminated malignant melanoma was made and the patient was treated symptomatically. The patient died in 4 months.

Verma Kaushal

1999-01-01

63

Metastatic melanoma and pregnancy  

Directory of Open Access Journals (Sweden)

Full Text Available Pregnancy after complete treatment of metastatic melanoma is an extremely rare event. We presented a case of a skin melanoma patient with lung and liver metastases who was treated by combined immunochemotherapy for the period of two years. A year and a half after the successful treatment, which resulted a complete remission of metastatic lesions she got pregnant and delivered a healthy baby girl.

Nikolin Borislava L.

2005-01-01

64

Amelanotic metastatic cutaneous melanoma.  

Science.gov (United States)

Dermatoscopy of melanocytic lesions has guided the decision of when or not to biopsy a lesion. The use of this tool has increased clinical examination's sensitivity and specificity in 89% and 96% respectively. However, dermatoscopic evaluation of amelanotic or hypomelanotic melanomas, as well as metastases, can be difficult. There is still no standardization for the analysis of these pathologies, which relies mostly on their vascular pattern. We describe the dermatoscopy of acral metastatic amelanotic melanoma. PMID:24474114

Mendes, Marcela Sena Teixeira; Costa, Mariana Carvalho; Gomes, Ciro Martins; de Araújo, Lisley Calixto; Takano, Gustavo Henrique Soares

2013-01-01

65

Angiogenesis in Melanoma  

Science.gov (United States)

Summary The process of angiogenesis is crucial for progression and metastasis of the majority of solid tumors including melanomas. The purpose of this review is to summarize existing knowledge of the mechanisms of angiogenesis in melanoma as well as current anti-angiogenic therapeutic strategies and their targets. Here, we have focused primarily on the role of key growth factors which are secreted by melanoma cells and known to trigger angiogenic responses, and their receptors as expressed on both endothelial and melanoma cells. Many of these growth factors function in synergy with receptors for extracellular matrix, integrins and matrix metalloproteinases. All these systems of molecules are activated during major stages of angiogenesis such as endothelial migration, proliferation and reorganization of surrounding extracellular matrix. The blockade of these molecules and their downstream pathways leads to inhibition of melanoma vascularization. Thus, these classes of molecules are essential for melanoma angiogenesis and, therefore, might serve as promising targets for therapeutic intervention. Many recently developed compounds targeting key pathways in angiogenesis are in their final stages of clinical trials. PMID:18083379

Mahabeleshwar, Ganapati H.; Byzova, Tatiana V.

2007-01-01

66

Primary malignant melanoma of prostate.  

Science.gov (United States)

Primary genitourinary melanoma accounts for less than one per cent of all cases of melanoma. Most cases attributed to the prostate actually originate from the prostatic urethra. Due to its infrequency, primary malignant melanoma of the genitourinary tract presents a difficult diagnostic and management challenge. We report a case of primary malignant melanoma of the prostate found during transurethral resection of the prostate. PMID:20882159

Doublali, M; Chouaib, A; Khallouk, A; Tazi, M F; El Fassi, M J; Farih, My H; Elfatmi, H; Bendahou, M; Benlemlih, A; Lamarti, O

2010-05-01

67

Primary malignant melanoma of prostate  

Directory of Open Access Journals (Sweden)

Full Text Available Primary genitourinary melanoma accounts for less than one per cent of all cases of melanoma. Most cases attributed to the prostate actually originate from the prostatic urethra. Due to its infrequency, primary malignant melanoma of the genitourinary tract presents a difficult diagnostic and management challenge. We report a case of primary malignant melanoma of the prostate found during transurethral resection of the prostate.

Doublali M

2010-01-01

68

[Prevention of cutaneous melanoma].  

Science.gov (United States)

Cutaneous melanoma exhibited a rapidly increasing incidence during the 70 s and 80 s. As a consequence primary and secondary prevention campaigns were developed, starting in Australia, where the incidence was by far the highest, but later also in the Netherlands. Mortality from melanoma in the Netherlands is stable at a rate of 2.4 per 100,000 person years since 1980. The melanoma incidence has stabilized since 1989 at a level of about 11 per 100,000. In the development of the melanoma it is not so much the accumulated exposure to sun that is of importance, as in squamous carcinoma, but rather incidental serious sunburn. It is especially exposure at an early age that increases the risk of melanoma as well as that of basal cell carcinoma. Primary prevention must be focussed on avoiding sunburn in young people. Secondary prevention can be realised by frequent controls of risk groups and a raised awareness for changing moles in the general population but also in physicians who see patients' skins for whatever reason. PMID:10416492

van der Rhee, H J; Coebergh, J W

1999-06-26

69

Melanoma tipo animal: relato de dois casos / Animal type melanoma: a report of two cases  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Dificuldade potencial no diagnóstico histológico de melanomas é a dificuldade em reconhecer variantes pouco frequentes de melanoma. Entre elas, as mais desafiantes incluem exemplos de melanoma desmoplásico, melanoma nevoide, o chamado "melanoma de desvio mínimo", melanomas com proeminente síntese de [...] pigmento ou "melanoma tipo animal" e o nevo azul maligno. Os autores descrevem dois casos de melanoma tipo animal e discute-se a importância do diagnóstico diferencial clinico-histopatológico nesses casos. Abstract in english A potential diagnostic pitfall in the histological assessment of melanomas is the difficulty in recognizing unusual melanoma variants. Among them, the most challenging examples comprise desmoplastic melanomas, nevoid melanomas, the so-called minimal-deviation melanoma, melanomas with prominent pigme [...] nt synthesis or animal-type melanoma, and the malignant blue nevus. Two cases of animal type melanoma are reported and the importance of clinical-histopathological differential diagnosis is discussed.

Mariângela Esther Alencar, Marques; Thamy, Yamashita; Silvio Alencar, Marques; Gisele Alborghetti, Nai.

70

MIR genes in Melanoma  

International Nuclear Information System (INIS)

On the basis of the previous project, further studies have been performed on the expression of selected miR genes in normal melanocytes and in melanoma cell lines, using real-time reverse transcription-PCR (qRT-PCR). In particular, we have analyzed the expression of 8 miR genes (i.e. 17-5p, 18a, 20a, 92a, 146a, 146b, 155, 221) in 10 different melanocyte cultures obtained from skin biopsies of 10 different healthy donors, and in 14 long-term human melanoma cell cultures

71

Melanoma esofágico primario / Primary esophageal melanoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish El melanoma esofágico primario (MEP) es una neoplasia extremadamente rara, con menos de 270 casos descritos. Aunque la presentación clínica es similar a cualquier otra neoplasia esofágica, su comportamiento es más agresivo y fatal en la mayoría de los casos. Presentamos dos nuevos casos de MEP diagn [...] osticados mediante endoscopia y estudio anatomopatológico de las biopsias obtenidas, siendo en ambos casos las muestras positivas para HMB-45 y S100, descartando así mismo la presencia de melanoma primario en otra localización. En el primer caso merece destacar la forma de presentación como miosis izquierda sin ptosis palpebral ni enoftalmos, siendo el primer caso descrito con esta manifestación inicial, lamentablemente al momento del diagnóstico fue irresecable, demostrando así mismo por ecoendoscopia afectación de la aorta torácica. El segundo caso a pesar de ser una neoplasia sin extensión locorregional y sometido a esofaguectomía transhiatal presentó múltiples complicaciones postoperatorias falleciendo al decimo noveno día de la intervención. Así mismo se hace una revisión bibliográfica sobre diagnóstico, opciones de tratamiento y pronóstico de esta excepcional neoplasia. Abstract in english Primary Esophageal Melanoma (PEM) is an extremely rare neoplasm, with less than 270 cases described. Although clinical presentation is similar to any other esophageal neoplasm, MEP's behavior is more aggressive and fatal in most cases. We report two new cases of MEP diagnosed through endoscopy and a [...] natomical-pathological analysis of collected biopsies. Both samples were positive for HMB-45 and S100, so the presence of primary melanoma in other location was ruled out. The form of presentation as left miosis with no eyelid ptosis or enophthalmos should be highlighted in the first case, which was described by this early manifestation. Unfortunately, the neoplasm could not be excised when diagnosed because the thoracic artery was found to be affected through echoendoscopy. In the second case, in spite of the fact that the neoplastic extension was only local, and neoplasm was subject to transhiatal esophagectomy, the patient had multiple post-surgical complications and died nineteen days after the surgical procedure. Furthermore, bibliographic review is applied to diagnosis, treatment options, and prognosis of this exceptional neoplasm.

Robin, Rivera Irigoín; Víctor, Aguilar Urbano; Juana, Gonzalo Marín; Cristobal, Albandea Moreno; Francisco, Fernández Pérez; Andrés, Sánchez Cantos.

2009-04-01

72

Melanoma acral lentiginoso: revisión bibliográfica / Acral lentiginous melanoma: bibliographic review  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish El melanoma acral lentiginoso es el tipo de melanoma de localización distal más frecuente, suele diagnosticarse en los estadios más avanzados y tiene un comportamiento biológico más agresivo que otros tipos de melanoma, por lo cual son de peor pronóstico. Representa entre el 5 % y el 10 % de los mel [...] anomas malignos y es más frecuente en asiáticos, en la raza negra y en latinoamericanos. El objetivo de este artículo fue hacer una revisión bibliográfica actualizada con el fin de conocer las tasas de incidencia del tumor, los nuevos avances con respecto a los factores de riesgo, biología molecular, diagnóstico y tratamiento, y el desarrollo de nuevos tratamientos en el manejo del melanoma avanzado y metastásico. Abstract in english Acral lentiginous melanomas, the melanomas most commonly found the distal portions of the limbs, have usually reached more advanced stages than other types of melanoma when diagnosed. Their biologic behavior is more aggressive than in other types of melanoma, so that they have a worse prognosis. It [...] represents 5 to 10% of all malignant melanomas, and is more frequently seen among the Asian, African American and Latin population. The objective of this paper was to complete a review of the current literature, in order to establish the rates of incidence, new findings regarding risk factors, molecular biology, diagnosis and treatment, and the development of new target therapies in the management of advanced and metastatic melanomas.

Carlos, Duarte; Héctor, López.

73

Melanoma acral lentiginoso: revisión bibliográfica / Acral lentiginous melanoma: bibliographic review  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish El melanoma acral lentiginoso es el tipo de melanoma de localización distal más frecuente, suele diagnosticarse en los estadios más avanzados y tiene un comportamiento biológico más agresivo que otros tipos de melanoma, por lo cual son de peor pronóstico. Representa entre el 5 % y el 10 % de los mel [...] anomas malignos y es más frecuente en asiáticos, en la raza negra y en latinoamericanos. El objetivo de este artículo fue hacer una revisión bibliográfica actualizada con el fin de conocer las tasas de incidencia del tumor, los nuevos avances con respecto a los factores de riesgo, biología molecular, diagnóstico y tratamiento, y el desarrollo de nuevos tratamientos en el manejo del melanoma avanzado y metastásico. Abstract in english Acral lentiginous melanomas, the melanomas most commonly found the distal portions of the limbs, have usually reached more advanced stages than other types of melanoma when diagnosed. Their biologic behavior is more aggressive than in other types of melanoma, so that they have a worse prognosis. It [...] represents 5 to 10% of all malignant melanomas, and is more frequently seen among the Asian, African American and Latin population. The objective of this paper was to complete a review of the current literature, in order to establish the rates of incidence, new findings regarding risk factors, molecular biology, diagnosis and treatment, and the development of new target therapies in the management of advanced and metastatic melanomas.

Carlos, Duarte; Héctor, López.

2014-06-01

74

Spice Blocks Melanoma Growth  

Science.gov (United States)

Curcumin, the pungent yellow spice found in both turmeric and curry powders, blocks a key biological pathway needed for development of melanoma and other cancers, according to a study that appears in the journal Cancer. Researchers from The University of Texas M. D. Anderson Cancer Center demonstrate how curcumin stops laboratory strains of…

Science Teacher, 2005

2005-01-01

75

Radiotherapy of malignant melanoma  

International Nuclear Information System (INIS)

The role of radiotherapy in the treatment of malignant melanoma is limited, and surgery generally forms the mainstay of medical practice. However, there are some circumstances in which radiotherapy should be considered the treatment of choice. Symptomatic metastatic lesions in bone or brain can effectively be palliated in a substantial proportion of instances. At the current stage of our knowledge, conventionally fractionated treatment of such lesions forms the standard against which other treatments should be measured. In contrast, metastatic lesions to skin or lymph nodes that do not overlie critical normal structures probably are better treated by high-dose-per-fraction techniques. Radiotherapy may play a definitive role in the treatment of lentigo maligna. The precise optimal energy of the beam to be used remains to be defined. Slightly more penetrating radiation appears to be required for lentigo maligna melanomas. Here, too, the optimal energy remains to be defined. The treatment of nonlentigenous melanomas primarily by radiotherapy is unproved in my opinion. Certainly, the data from the Princess Margaret Hospital is exciting, but I believe it must be corroborated by a well-designed trial before it can be accepted without question. Future directions in treatment of malignant melanoma are likely to include further trials of unconventional fractionation and the use of radiosensitizing agents in conjunction with radiotherapy. The time for dermatologists and radiation therapists to cooperate in such studies is at hand

76

Melanoma Histology Rules Flowchart  

Science.gov (United States)

Notes and Examples Flowchart Key Flow Direction Notes and Examples Rule Action Code the numerically higher ICD-O-3 histology code. This is the end of ins truc tions for S ingle Melanoma or Multiple Melanom as Abstrac ted as a Single Primary. Code the histology acc ording to the rule that fits the case.

77

[Dermatofibroma or melanoma?].  

Science.gov (United States)

Three patients (51-, 72- and 53-year old) revealed in dermoscopy dermatofibroma-like features on skin lesions at their back. According to the pattern, 3-4 dermatofibroma side-by-side could be suggested. Differences of the principle features - postinflammatory hyperpigmentation at the periphery surrounding central scar-like hypopigmentations - must also include the differential diagnosis of a melanoma. PMID:22751859

Blum, A; Hofmann-Wellenhof, R

2012-07-01

78

Primary penile melanoma.  

Science.gov (United States)

Primary penile melanomas are exceedingly rare (less than 1% of primary penile cancers), 221 cases being reported to date in PubMed indexed medical literature. More than half of the cases occur on the gland, usually in older people than on cutaneous counterpart and have unfavourable prognosis mainly due to the belated diagnosis. We report the case of a 77 years old male diagnosed with a pigmented ulcerated nodular melanoma of the gland with maximal thickness of 4.5 mm, mitotic index 8 mitoses/mm2 and vascular emboli. No lymph node enlargements or distant metastases were identified at presentation. Six months after the diagnosis the patient was well, free of disease. Clinically, penile melanomas may be mistaken for several lesions such as squamous carcinoma, penile nevi, pyogenic granuloma, Kaposi sarcoma. Histopathologic diagnosis is usually straight forward except for highly pleomorphic tumors; discrimination between primary penile tumor and penile metastatic melanoma is the most delicate problem of differential diagnosis. The treatment is not standardized; surgical wide excision or partial/total penectomy completed with sentinel lymph node biopsy are the most frequent methods of treatment; multi-agent chemotherapy and/or high-dose interferon alpha 2b therapy are recommended for patients with locally un-controllable disease and/or metastases. PMID:25338349

Andrei, R; Cioplea, Mirela; Mageriu, V; Chuaibi, A; Cauni, V; Zurac, Sabina; Staniceanu, Florica

2014-01-01

79

Melanoma risk prediction models  

Directory of Open Access Journals (Sweden)

Full Text Available Background/Aim. The lack of effective therapy for advanced stages of melanoma emphasizes the importance of preventive measures and screenings of population at risk. Identifying individuals at high risk should allow targeted screenings and follow-up involving those who would benefit most. The aim of this study was to identify most significant factors for melanoma prediction in our population and to create prognostic models for identification and differentiation of individuals at risk. Methods. This case-control study included 697 participants (341 patients and 356 controls that underwent extensive interview and skin examination in order to check risk factors for melanoma. Pairwise univariate statistical comparison was used for the coarse selection of the most significant risk factors. These factors were fed into logistic regression (LR and alternating decision trees (ADT prognostic models that were assessed for their usefulness in identification of patients at risk to develop melanoma. Validation of the LR model was done by Hosmer and Lemeshow test, whereas the ADT was validated by 10-fold cross-validation. The achieved sensitivity, specificity, accuracy and AUC for both models were calculated. The melanoma risk score (MRS based on the outcome of the LR model was presented. Results. The LR model showed that the following risk factors were associated with melanoma: sunbeds (OR = 4.018; 95% CI 1.724- 9.366 for those that sometimes used sunbeds, solar damage of the skin (OR = 8.274; 95% CI 2.661-25.730 for those with severe solar damage, hair color (OR = 3.222; 95% CI 1.984-5.231 for light brown/blond hair, the number of common naevi (over 100 naevi had OR = 3.57; 95% CI 1.427-8.931, the number of dysplastic naevi (from 1 to 10 dysplastic naevi OR was 2.672; 95% CI 1.572-4.540; for more than 10 naevi OR was 6.487; 95%; CI 1.993-21.119, Fitzpatricks phototype and the presence of congenital naevi. Red hair, phototype I and large congenital naevi were only present in melanoma patients and thus were strongly associated with melanoma. The percentage of correctly classified subjects in the LR model was 74.9%, sensitivity 71%, specificity 78.7% and AUC 0.805. For the ADT percentage of correctly classified instances was 71.9%, sensitivity 71.9%, specificity 79.4% and AUC 0.808. Conclusion. Application of different models for risk assessment and prediction of melanoma should provide efficient and standardized tool in the hands of clinicians. The presented models offer effective discrimination of individuals at high risk, transparent decision making and real-time implementation suitable for clinical practice. A continuous melanoma database growth would provide for further adjustments and enhancements in model accuracy as well as offering a possibility for successful application of more advanced data mining algorithms.

Nikoli? Jelena

2014-01-01

80

Radiopharmaceuticals targeting melanoma  

Energy Technology Data Exchange (ETDEWEB)

Melanoma is one of the most aggressive cancers known with a high rate of mortality and increasing global incidence. So, the development of radiopharmaceuticals for either diagnostic or therapeutic purposes could make enormous contributions to melanoma patient health care. We have been studying melanoma tumours through several targeting mechanisms including melanin or specific receptor based radiopharmaceuticals Structure activity studies indicate that the substitution patterns on radioiodinated benzamides significantly influence the uptake mechanism from melanin to sigma-receptor binding. Furthermore, the position of the iodine as well as the presence of key functional groups and substituents has resulted in compounds with varying degrees of activity uptake and retention in tumours. From these results, a novel molecule 2-(2-(4-(4-iodo benzyl)piperazin-1-yl)-2-oxo-ethyl)isoindoline- 1,3-dione (M.E.L.037) was synthesized, labelled with iodine-123 and evaluated for application in melanoma tumour scintigraphy and radiotherapy. The tumour imaging potential of {sup 123}IM.E.L.037 was studied in vivo in C.57 B.L./ 6 J female mice bearing the B.16 F.0. murine melanoma tumour and in BALB/c nude mice bearing the A.375 human amelanotic melanoma tumour by biodistribution, competition studies and by SPECT imaging. {sup 123}I-M.E.L.037 exhibited high and rapid uptake in the B.16 F.0 melanoma tumour at 1 h (13 % I.D./g) increasing with time to reach 25 % I.D./g at 6 h. A significant uptake was also observed in the eyes (2% I.D., at 3-6 h p.i.) of black mice. No uptake was observed in the tumour or in the eyes of nude mice bearing the A.375 tumour. Due to high uptake and long retention in the tumour and rapid body clearance, standardized uptake values(S.U.V.) of {sup 123}I-M.E.L.037 were 30 and 60, at 24 and 48 h p.i.,respectively. SPECT imaging of mice bearing the B.16 melanoma indicated the radioactivity was predominately located in the tumour followed by the eyes, while no specific localisation of the radioactivity was noticed in mice bearing A.375 human amelanotic tumour. In competition experiments,uptake of {sup 123}I-M..E.L.037 in brain, lung, heart and kidney, organs known to contain s-receptors, was not significantly different in haloperidol treated animals compared to controls. Therefore,reduction of uptake in tumour and eyes of the pigmented mice bearing the B.16 F.0 tumour suggested that the mechanism of tumour uptake was likely due to an interaction with melanin.These findings suggested that {sup 123}I-M.E.L.037, which displays a rapid and very high tumour uptake, appeared to be a promising imaging agent for detection of most melanoma tumours with the potential for development as a therapeutic agent in melanoma tumour proliferation. (authors)

Pham, T.Q.; Berghofer, P.; Liu, X.; Greguric, I.; Dikic, B.; Ballantyne, P.; Mattner, F.; Nguyen, V.; Loc' h, C.; Katsifis, A. [Radiopharmaceuticals Research Institute, Australian Nuclear Science and Technology Organisation, Menai, N.S.W., Sydney (Australia)

2008-02-15

 
 
 
 
81

El melanoma en México  

Directory of Open Access Journals (Sweden)

Full Text Available El melanoma maligno es el tumor más letal de los tumores de piel por su gran capacidad de producir metástasis y por su alta quimiorresistencia. En México es evidente el aumento de esta neoplasia, con una evolución de casi 500% en los últimos años. El melanoma es una neoplasia que se origina en los melanocitos que derivan de la cresta neural. El subtipo acral lentiginoso, que es el más frecuente en nuestro país, se manifiesta en las palmas, las plantas y la zona subungueal. En estadios tempranos el tratamiento es quirúrgico, pero en estadios tardíos rara vez es curable con tratamiento estándar. Existen reportes de que las respuestas al tratamiento quimioterapéutico difícilmente favorecen a más de 20% de los pacientes. La quimiorresistencia actualmente no se explica por completo con los mecanismos y moléculas descritos hasta la fecha. Nuestro laboratorio ha hecho una búsqueda de genes, relacionados con esta quimiorresistencia, por medio de la técnica de expresión diferencial de genes y ha encontrado un gen altamente expresado en el tejido del melanoma acral y homologado al 100% con el gen ABCB5. Por medio de la reacción en cadena de la polimerasa en tiempo real se encontró que la expresión del gen encontrado se halla entre 26 y 1320%, con mayor expresión del gen MDR1 -el cual actúa como bomba que expulsa los quimioterapéuticos- cuando se hace una comparación con tejido sano. Por otro lado, la expresión del gen ERCC1, encargado de reparar el ADN dañado, la identificamos casi 50% más baja en melanoma que en tejido sano, lo que podría ser un factor de riesgo para padecer melanoma.

Norma Estela Herrera Gonzu00E1lez

2010-01-01

82

[Amelanotic malignant melanoma: about three cases].  

Science.gov (United States)

The amelanotic melanoma is a rare type of malignant melanoma. The purpose of this report is to point out this aspect of melanoma, whose diagnostic delay is frequent. We describe one localisation on the penis, rare in this kind of melanoma and two cases of the extremities, more frequent localization of the amelanotic melanoma. The therapeutic issues and recommendation are similar to the classical pigmented malignant melanoma. PMID:17030390

Mercadier, B; Hu, W; Valentin, S; Sassolas, B

2007-02-01

83

MicroRNA in Melanoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Melanoma is a highly aggressive and deadly skin cancer. Early intervention correlates with nearly 100% patient survival, but greater than 80% mortality is associated with advanced disease. Currently, few treatment options are available for patients with metastatic melanoma, and the global incidence of melanoma is increasing faster than that of other cancers. Therefore, it is vitally important to uncover and use genetic and epigenetic regulatory mechanisms at work during the development and pr...

Howell, Paul M.; Li, Xiaobo; Riker, Adam I.; Xi, Yaguang

2010-01-01

84

Melanomas in renal transplant recipients.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

BACKGROUND: It is well documented that renal transplant recipients are at increased risk of developing skin cancers, in particular squamous cell carcinomas. Less extensively reviewed in the literature is the increased incidence of malignant melanoma. We have reviewed 10 patients in the Oxford renal transplant population who developed 12 melanomas following transplantation. OBJECTIVES: To determine the incidence and characteristics of melanoma in renal transplant recipients. METHODS: We review...

Le Mire, L.; Hollowood, K.; Gray, D; Bordea, C.; Wojnarowska, F.

2006-01-01

85

Genetics and genomics of melanoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The rapidly increasing incidence of melanoma, coupled with its highly aggressive metastatic nature, is of urgent concern. In order to design rational therapies, it is of critical importance to identify the genetic determinants that drive melanoma formation and progression. To date, signaling cascades emanating from the EGF receptor, c-MET and other receptors are known to be altered in melanoma. Important mutations in signaling molecules, such as BRAF and N-RAS, have been identified. In this r...

Ghosh, Papia; Chin, Lynda

2009-01-01

86

Simvastatin impairs murine melanoma growth  

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Abstract Background Statins induces cell cycle arrest, apoptosis, reduction of angiogenic factors, inhibition of the endothelial growth factor, impairing tissue adhesion and attenuation of the resistance mechanisms. The aim of this study was evaluate the anti-tumoral activity of simvastatin in a B16F10 melanoma-mouse model. Methods Melanoma cells were treated with different concentrations of simvastatin and assessed by viability methods. Melanoma cells (5 × 10<...

Barros Francisco E; Borelli Primavera; Bohatch Milton S; Oliveira Karen A; Otuki Michel, F.; Favero Giovani M; Maria Durvanei A; Fernandes Daniel; Bydlowski Sergio P

2010-01-01

87

CT Findings of Metastatic Melanoma  

International Nuclear Information System (INIS)

Melanoma is a rare tumor of the skin; however, it has the highest mortality rate among these neoplasms, and its incidence continues to increase. Malignant melanoma can metastasize to any part of the body, and the lymph nodes and lungs are the sites most commonly affected. Imaging findings of some of these metastases and of the organs involved are quite characteristic. This article discusses some of the fairly typical imaging findings and locations of metastases to multiple organs in malignant melanoma.

88

Primary malignant melanoma of gallbladder.  

Science.gov (United States)

Gallbladder primary malignant melanoma (GPMM) is a rare and controversial entity. The existing controversy on the subject appears mainly because of the lack of definitive objective criteria of primitivity. Objective criteria proposed by the specific literature for distinguishing GPMM from secondary gallbladder melanoma include the exclusion of previous primitive melanoma, absence of synchronous involment of other sites, the unicity of lesion, its polipoid or papilary shape and the presence of a junctional melanocitary component. After laparoscopic cholecystectomy in one of our patients, dark polypus inside the gallbladder was found. A malignant melanoma was diagnosed according to all five criteria for GPMM. PMID:21263401

Pitlovi?, Vlatka; Lati?, Ferid; Pitlovi?, Hrvoje; Rupci?, Mario; Jurisi?, Darko; Lati?, Azra

2011-02-01

89

Primary malignant melanoma of gallbladder  

Directory of Open Access Journals (Sweden)

Full Text Available Gallbladder primary malignant melanoma (GPMM is a rare and controversial entity. The existing controversy on the subject appears mainly because of the lack of deinitive objective criteriaof primitivity. Objective criteria proposed by the speciic literature for distinguishing GPMM from secondary gallbladder melanoma include the exclusion of previous primitive melanoma, absence of synchronous involment of other sites, the unicity of lesion, its polipoid or papilary shape and the presence of a junctional melanocitary component. After laparoscopic cholecystectomy in one of our patients, dark polypus inside the gallbladder was found. A malignant melanoma was diagnosed according to all ive criteria for GPMM.

Vlatka Pitlovi?

2011-02-01

90

Malignant melanoma of the rectum.  

Science.gov (United States)

Malignant melanoma of the rectum is an extremely rare disease. It typically presents in the fifth or sixth decade of life with nonspecific complaints such as rectal bleeding or anal pain. A timely diagnosis of anal melanoma is made even more difficult by the fact that most of the lesions lack obvious pigmentation and are even histologically amelanotic. Prognosis is very poor. Anorectal malignant melanomas spread along submucosal planes and are often beyond complete resection at the time of diagnosis. We present the radiological and pathological features seen in a 43-year-old woman diagnosed with melanoma of the rectum. PMID:24678436

Kohli, Supreethi; Narang, Seema; Singhal, Anu; Kumar, Vinod; Kaur, Omkar; Chandoke, Raj

2014-01-01

91

Management of vaginal melanoma  

International Nuclear Information System (INIS)

Between 1964 and 1987, nine patients with vaginal melanoma were treated at the authors' institution. five of six patients who underwent radical surgery had adequate information concerning the first site of relapse, and in four of these five cases, pelvic sites or regional lymph nodes were the first sites of recurrent disease. One of these patients developed a 17-cm pelvic recurrence, which responded with a 75% reduction in size 3 months after completion of radiotherapy given in high individual fractions (400 cGy X 11). Two patients were managed with local resection, and both failed locally. One patient presented with metastatic disease. The authors hypothesize that preoperative radiotherapy to the pelvis (500 cGy X 7) may improve the poor rate of local control of vaginal melanoma that is seen when surgery alone is employed

92

Nodular amelanotic melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available We report a case of 65-year-old male patient who presented with multiple erythematous papules coalescing to form a nodular mass over posterior aspect of right thigh of six months duration. His general and systemic examinations were within normal range except for right inguinal lymphadenopathy. Biopsy from the lesion was done, which showed diffuse infiltrate of nests of atypical melanocytes extending upto reticular dermis. Malignant cells were positive for S100 and human melanin black 45(HMB 45. Hence, a diagnosis of amelanotic melanoma (AM - Clarke level IV and TNM stage III was reached. MRI of involved leg showed fungating soft tissue mass in the posterolateral aspect of right thigh and metastatic right inguinal adenopathy. Fine needle aspiration cytology (FNAC from the right inguinal nodes confirmed metastasis of melanoma. The patient was referred to oncosurgery department for further management.

Nalamwar Rashmi

2010-01-01

93

Primary pineal malignant melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Primary pineal malignant melanoma is a rare entity, with only thirteen cases reported in the world literature to date. We report a case of a 70-year-old man, who consulted with gait disturbance of six months duration, associated in the last month with dizziness, visual abnormalities and diplopia. No other additional melanocytic lesions were found elsewhere. The magnetic resonance showed a 25 mm expansive mass in the pineal gland that was associated with hydrocephaly, ventricular and transependimary oedema. The lesion was partially excised by a supracerebellar infratentorial approach. The histological examination revealed a melanoma. The patient received radiation therapy, but died of disease 16 weeks later. We herein review the literature on this rare tumour and comment on its clinical, radiological and histopathological features and differential diagnosis.

Cesar La Cruz Pelea

2011-05-01

94

Chemoprevention of Melanoma  

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Despite advances in drug discovery programs and molecular approaches for identifying the drug targets, incidence and mortality rates due to melanoma continues to rise at an alarming rate. Existing preventive strategies generally involve mole screening followed by surgical removal of the benign nevi and abnormal moles. However, due to lack of effective programs for screening and disease recurrence after surgical resection there is a need for better chemopreventive agents. Although sunscreens h...

Madhunapantula, Subbarao V.; Robertson, Gavin P.

2012-01-01

95

Primary pineal malignant melanoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Primary pineal malignant melanoma is a rare entity, with only thirteen cases reported in the world literature to date. We report a case of a 70-year-old man, who consulted with gait disturbance of six months duration, associated in the last month with dizziness, visual abnormalities and diplopia. No other additional melanocytic lesions were found elsewhere. The magnetic resonance showed a 25 mm expansive mass in the pineal gland that was associated with hydrocephaly, ventricular and transepen...

Cesar La Cruz Pelea; Oderay Mabel Cedeño Díaz; Roberto Garcia Leal

2011-01-01

96

Radiotherapy of malignant melanomas  

International Nuclear Information System (INIS)

A study is made of 46 patients with cutaneous and mucoseous malignant melanoma treated in the Department of Radiotherapy of. A.C. Camargo Hospital - Fundacao Antonio Prudente - Sao Paulo - Brazil, from 1960 to 1973. Radiotherapy was employed as a radical procedure in 9 patients, as a, remissive procedure in 10 and as an adjuvant pre-or post-operative therapeutic in 22 patients. Six patients were submitted to actnic hipophysectomy. One out of the cases submitted to radical radiotherapy showed complete response and six patients partial response. Seven out of the ten cases treated with paliative intention did not show symptomatology after radiotherapy that led them to treatment. Under the ever-existing conflict of the clinical literature and experimentation, it is found that there had not been estabilished a definite concept concerning radiosensibility of malignant melanomas yet. The different response to the radiation-therapy from one case to another makes the local prognostic unsafe. It is concluded that the role of radiotherapy has not been perfectly estabilished in the therapeutic approach of malignant melanoma and that prospective studies are needed to situate radiotherapy in the treatment of this disease. (Author)

97

Radiopharmaceuticals targeting melanoma  

International Nuclear Information System (INIS)

with time to reach 25 % I.D./g at 6 h. A significant uptake was also observed in the eyes (2% I.D., at 3-6 h p.i.) of black mice. No uptake was observed in the tumour or in the eyes of nude mice bearing the A.375 tumour. Due to high uptake and long retention in the tumour and rapid body clearance, standardized uptake values(S.U.V.) of 123I-M.E.L.037 were 30 and 60, at 24 and 48 h p.i.,respectively. SPECT imaging of mice bearing the B.16 melanoma indicated the radioactivity was predominately located in the tumour followed by the eyes, while no specific localisation of the radioactivity was noticed in mice bearing A.375 human amelanotic tumour. In competition experiments,uptake of 123I-M..E.L.037 in brain, lung, heart and kidney, organs known to contain s-receptors, was not significantly different in haloperidol treated animals compared to controls. Therefore,reduction of uptake in tumour and eyes of the pigmented mice bearing the B.16 F.0 tumour suggested that the mechanism of tumour uptake was likely due to an interaction with melanin.These findings suggested that 123I-M.E.L.037, which displays a rapid and very high tumour uptake, appeared to be a promising imaging agent for detection of most melanoma tumours with the potential for development as a therapeutic agent in melanoma tumour proliferation. (authors)

98

ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma  

Energy Technology Data Exchange (ETDEWEB)

Research highlights: {yields} Strong ADAM15 expression is found in normal melanocytes. {yields} ADAM15 expression is significantly downregulated in patients with melanoma metastasis. {yields} TGF-{beta} can downregulate ADAM15 expression in melanoma cells. {yields} Overexpression of ADAM15 in melanoma cells inhibits migration, proliferation and invasion of melanoma cells. {yields} Conclusion: ADAM15 represents an tumor suppressor protein in melanoma. -- Abstract: In a mouse melanoma metastasis model it has been recently shown that ADAM15 overexpression in melanoma cells significantly reduced the number of metastatic nodules on the lung. Unfortunately, the expression of ADAM15 in human melanoma tissue has not been determined so far. In our study, we characterized the expression of ADAM15 in tissue micro-arrays of patients with primary melanoma with melanoma metastasis. ADAM15 was expressed in melanocytes and endothelial cells of benign nevi and melanoma tissue. Importantly, ADAM15 was significantly downregulated in melanoma metastasis compared to primary melanoma. We further demonstrate that IFN-{gamma} and TGF-{beta} downregulate ADAM15 protein levels in melanoma cells. To investigate the role of ADAM15 in melanoma progression, we overexpressed ADAM15 in melanoma cells. Importantly, overexpression of ADAM15 in melanoma cells reduced the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. In summary, the downregulation of ADAM15 plays an important role in melanoma progression and ADAM15 act as a tumorsuppressor in melanoma.

Ungerer, Christopher; Doberstein, Kai [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany); Buerger, Claudia; Hardt, Katja; Boehncke, Wolf-Henning [Department of Dermatology, Clinic of the Goethe-University, Theodor-Stern-Kai, Frankfurt (Germany); Boehm, Beate [Division of Rheumatology, Goethe University, Frankfurt am Main (Germany); Pfeilschifter, Josef [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany); Dummer, Reinhard [Department of Pathology, Institute of Surgical Pathology, University Hospital, Zurich (Switzerland); Mihic-Probst, Daniela [Department of Dermatology, University Hospital Zurich (Switzerland); Gutwein, Paul, E-mail: p.gutwein@med.uni-frankfurt.de [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany)

2010-10-22

99

ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma  

International Nuclear Information System (INIS)

Research highlights: ? Strong ADAM15 expression is found in normal melanocytes. ? ADAM15 expression is significantly downregulated in patients with melanoma metastasis. ? TGF-? can downregulate ADAM15 expression in melanoma cells. ? Overexpression of ADAM15 in melanoma cells inhibits migration, proliferation and invasion of melanoma cells. ? Conclusion: ADAM15 represents an tumor suppressor protein in melanoma. -- Abstract: In a mouse melanoma metastasis model it has been recently shown that ADAM15 overexpression in melanoma cells significantly reduced the number of metastatic nodules on the lung. Unfortunately, the expression of ADAM15 in human melanoma tissue has not been determined so far. In our study, we characterized the expression of ADAM15 in tissue micro-arrays of patients with primary melanoma with melanoma metastasis. ADAM15 was expressed in melanocytes and endothelial cells of benign nevi and melanoma tissue. Importantly, ADAM15 was significantly downregulated in melanoma metastasis compared to primary melanoma. We further demonstrate that IFN-? and TGF-? downregulate ADAM15 protein levels in melanoma cells. To investigate the role of ADAM15 in melanoma progression, we overexpressed ADAM15 in melanoma cells. Importantly, overexpression of ADAM15 in melanoma cells reduced the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. In summary, the downregulation of ADAM15 plays an important role in melanoma progression and ADAM15 act as a tumorsuppressor in melanoma.

100

Radiation biology of malignant melanoma  

International Nuclear Information System (INIS)

treated by use of conventional fractionation regimes, either based on 2 Gy or higher doses per fraction. Consequently, optimum radiation therapy of malignant melanoma will probably require an individualized treatment strategy. In vitro assays for prediction of radiocurability and choice of treatment strategy for individual melanoma patients seem therefore highly warranted. (orig.)

 
 
 
 
101

Keeping a watch on melanoma.  

Science.gov (United States)

When performing a total body skin examination, we discovered a melanoma in situ when a patient took off her wristwatch. This case illustrates the importance of removing jewelry when performing a complete skin examination. Furthermore, the location of this lesion highlights the association between malignant melanoma and intermittent sun exposure. PMID:12041820

Casparian, J Michael; Rodewald, Erin J

2002-05-01

102

Skin Cancer Non-Melanoma  

Medline Plus

Full Text Available X-Plain Skin Cancer Non-Melanoma Reference Summary Introduction Each year, millions of people find out that they have skin cancer. Skin cancer is ... and squamous cell carcinoma are sometimes called non- melanoma skin cancer. Another type of cancer that occurs in the ...

103

MicroRNA in Melanoma.  

Science.gov (United States)

Melanoma is a highly aggressive and deadly skin cancer. Early intervention correlates with nearly 100% patient survival, but greater than 80% mortality is associated with advanced disease. Currently, few treatment options are available for patients with metastatic melanoma, and the global incidence of melanoma is increasing faster than that of other cancers. Therefore, it is vitally important to uncover and use genetic and epigenetic regulatory mechanisms at work during the development and progression of melanoma for better prevention, diagnosis, and clinical management. MicroRNA (miRNA) is a set of small, single-stranded, noncoding RNAs that target the 3'-untranslated region of an estimated 30% of all human genes to inhibit their expression. Our understanding of miRNA-mediated regulation of cancers has grown immensely over the past decade. Here we review currently available data on melanoma-associated miRNAs, highlighting those deregulated miRNAs targeting important genes and signaling pathways involved in the progression of melanocytes to primary and metastatic melanoma. Understanding the important roles of miRNAs in melanoma progression and metastasis development will contribute to the development of miRNA-targeted therapy in the future. PMID:21603362

Howell, Paul M; Li, Xiaobo; Riker, Adam I; Xi, Yaguang

2010-01-01

104

Slug Expression during Melanoma Progression  

Science.gov (United States)

Slug (Snai2), a member of the Snail family of zinc finger transcription factors, plays a role in the epithelial-to-mesenchymal transformation (EMT) that occurs during melanocyte emigration from the neural crest. A role for Slug in the EMT-like loss of cell adhesion and increased cell motility exhibited during melanoma progression has also been proposed. Our immunohistochemical studies of melanoma arrays, however, revealed that Slug expression was actually higher in nevi than in primary or metastatic melanomas. Moreover, Slug expression in melanomas was not associated with decreased expression of E-cadherin, the canonical Slug target in EMT. Comparisons of endogenous Slug and E-cadherin expression in cultured normal human melanocytes and melanoma cell lines supported our immunohistochemical findings. Expression of exogenous Slug in melanocytes and melanoma cells in vitro, however, suppressed E-cadherin expression, enhanced N-cadherin expression, and stimulated cell migration and invasion. Interestingly, both in tumors and cultured cell lines, there was a clear relationship between expression of Slug and MITF, a transcription factor known to regulate Slug expression during development. Taken together, our findings suggest that Slug expression during melanomagenesis is highest early in the process and that persistent Slug expression is not required for melanoma progression. The precise role of Slug in melanomagenesis remains to be elucidated and may be related to its interactions with other drivers of EMT, such as Snail. PMID:22503751

Shirley, Stephanie H.; Greene, Victoria R.; Duncan, Lyn M.; Torres Cabala, Carlos A.; Grimm, Elizabeth A.; Kusewitt, Donna F.

2012-01-01

105

Slug expression during melanoma progression.  

Science.gov (United States)

Slug (Snai2), a member of the Snail family of zinc finger transcription factors, plays a role in the epithelial-to-mesenchymal transformation (EMT) that occurs during melanocyte emigration from the neural crest. A role for Slug in the EMT-like loss of cell adhesion and increased cell motility exhibited during melanoma progression has also been proposed. Our immunohistochemical studies of melanoma arrays, however, revealed that Slug expression was actually higher in nevi than in primary or metastatic melanomas. Moreover, Slug expression in melanomas was not associated with decreased expression of E-cadherin, the canonical Slug target in EMT. Comparisons of endogenous Slug and E-cadherin expression in cultured normal human melanocytes and melanoma cell lines supported our immunohistochemical findings. Expression of exogenous Slug in melanocytes and melanoma cells in vitro, however, suppressed E-cadherin expression, enhanced N-cadherin expression, and stimulated cell migration and invasion. Interestingly, both in tumors and cultured cell lines, there was a clear relationship between expression of Slug and MITF, a transcription factor known to regulate Slug expression during development. Taken together, our findings suggest that Slug expression during melanomagenesis is highest early in the process and that persistent Slug expression is not required for melanoma progression. The precise role of Slug in melanomagenesis remains to be elucidated and may be related to its interactions with other drivers of EMT, such as Snail. PMID:22503751

Shirley, Stephanie H; Greene, Victoria R; Duncan, Lyn M; Torres Cabala, Carlos A; Grimm, Elizabeth A; Kusewitt, Donna F

2012-06-01

106

Animal type melanoma: a report of two cases  

Directory of Open Access Journals (Sweden)

Full Text Available Dificuldade potencial no diagnóstico histológico de melanomas é a dificuldade em reconhecer variantes pouco frequentes de melanoma. Entre elas, as mais desafiantes incluem exemplos de melanoma desmoplásico, melanoma nevoide, o chamado "melanoma de desvio mínimo", melanomas com proeminente síntese de pigmento ou "melanoma tipo animal" e o nevo azul maligno. Os autores descrevem dois casos de melanoma tipo animal e discute-se a importância do diagnóstico diferencial clinico-histopatológico nesses casos.A potential diagnostic pitfall in the histological assessment of melanomas is the difficulty in recognizing unusual melanoma variants. Among them, the most challenging examples comprise desmoplastic melanomas, nevoid melanomas, the so-called minimal-deviation melanoma, melanomas with prominent pigment synthesis or animal-type melanoma, and the malignant blue nevus. Two cases of animal type melanoma are reported and the importance of clinical-histopathological differential diagnosis is discussed.

Mariângela Esther Alencar Marques

2010-08-01

107

Melanoma Surveillance in the US: The Economic Burden of Melanoma  

Centers for Disease Control (CDC) Podcasts

This podcast accompanies the publication of a series of articles on melanoma surveillance in the United States, available in the November supplement edition of the Journal of the American Academy of Dermatology. Dr. Gery Guy, from the CDCâ??s Division of Cancer Prevention and Control, discusses the economic burden of melanoma.  Created: 10/19/2011 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/19/2011.

2011-10-19

108

Skin Cancer Non-Melanoma  

Medline Plus

Full Text Available X-Plain Skin Cancer Non-Melanoma Reference Summary Introduction Each year, millions of people find out that they have skin cancer. Skin cancer is almost 100% curable if found early and ...

109

Skin Cancer Non-Melanoma  

Medline Plus

Full Text Available ... cell and basal cell carcinoma, not melanoma. Causes & Prevention Skin cancer is one of the most common ... better to prevent than to treat skin cancer! Prevention involves avoiding long exposure to the sun and ...

110

Orbital metastasis from cutaneous melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available We report a case of a metastatic cutaneous melanoma to the orbit. A 60-year-old Caucasian male presented with a 2-day history of left-sided ocular pain, lid swelling and chemosis. Initially, this was treated as conjunctivitis with no signs of improvement. Four days later, the patient developed left proptosis, mechanical ptosis, left esotropia and diplopia. Computed tomography scan of the orbit demonstrated marked thickening of the lateral rectus muscle. The patient was treated as pseudotumor. Subsequent biopsy revealed malignant cutaneous melanoma. The patient had a history of cutaneous melanoma excised 15 years previously. Further imaging showed advanced metastatic disease in the brain, the lung and the liver. The patient passed away five months after initial presentation. Cutaneous melanoma metastasizing to the orbit has poor prognosis. Patients often have advanced disease at the time of presentation and orbital metastases may be the initial sign. A detailed history is paramount in making timely diagnosis.

Samer Elsherbiny

2012-01-01

111

Combination Therapy for Advanced Melanoma  

Science.gov (United States)

In this clinical trial, researchers are testing chemotherapy with the drugs carboplatin and paclitaxel in combination with a new drug called sorafenib (BAY 43-9006) in patients with advanced melanoma.

112

Skin Cancer Non-Melanoma  

Medline Plus

Full Text Available ... cell and basal cell carcinoma, not melanoma. Causes & Prevention Skin cancer is one of the most common ... After the cryosurgery area thaws, the dead skin falls off. More than one freezing may be needed. ...

113

Skin Cancer Non-Melanoma  

Medline Plus

Full Text Available ... cell and basal cell carcinoma, not melanoma. Causes & Prevention Skin cancer is one of the most common ... age. Therefore, protection should start in childhood to prevent skin cancer later in life. Whenever possible, people ...

114

Skin Cancer Non-Melanoma  

Medline Plus

Full Text Available ... squamous cell and basal cell carcinoma, not melanoma. Causes & Prevention Skin cancer is one of the most ... UV, radiation from the sun is the main cause of skin cancer. Artificial sources of UV radiation, ...

115

Dysplastic nevi and malignant melanoma.  

Science.gov (United States)

The incidence of melanoma has been steadily increasing, with a trend for this tumor to develop at younger ages. The only satisfactory treatment for melanoma is early intervention; therefore, routine screening for melanoma and dysplastic nevi during the general physical examination is important. The prevalence of dysplastic nevi is estimated to be 2 to 5 percent. Patients with dysplastic nevi appear to have at least a 6 percent lifetime risk of melanoma. In the most severely affected patients (those with a family history of dysplastic nevi and more than one melanoma), the lifetime risk may exceed 50 percent. Patients with dysplastic nevi merit periodic follow-up. Since these nevi tend to be familial, close relatives of affected patients may also benefit from a screening examination. Individuals at increased risk for melanoma may display one or more of the following risk factors: dysplastic nevi, freckling, tendency to sunburn and numerous common nevi. Such individuals may benefit most from education in sunburn avoidance, sunscreen use and self-examination for changing nevi. A better informed public and heightened physician awareness are the most effective means of reducing mortality from this virulent malignancy. PMID:2200246

Crutcher, W A; Cohen, P J

1990-08-01

116

Fulminant metastatic malignant melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available A 50-year-old lady presented with complaints of chest pain and cough for the past one month. Right supraclavicular lymphadenopathy, bilateral pleural effusion were present. Fine needle aspiration cytology (FNAC from the lymph node showed brownish-black pigment laden tumour cells. Review of history subsequently revealed that she had undergone a surgical procedure over the sole of her left foot three years ago of which no records were available. Reexamination of sole of left foot showed a pigmented infiltraling lesion. Pleural biopsy revealed pigmented tumour deposits. The patient was diagnosed to have fulminant metastatic malignant melanoma of left foot with metastasis to cervical lymph nodes and pleura. This case report re-emphasizes the importance of combined approach to ascertain diagnosis early.

N.M.K. Faheem,

2012-07-01

117

CDX-1401 and Poly-ICLC Vaccine Therapy With or Without CDX-301in Treating Patients With Stage IIB-IV Melanoma  

Science.gov (United States)

Ciliary Body and Choroid Melanoma, Medium/Large Size; Ciliary Body and Choroid Melanoma, Small Size; Extraocular Extension Melanoma; Iris Melanoma; Metastatic Carcinoma of Unknown Primary; Metastatic Intraocular Melanoma; Mucosal Melanoma; Stage IIB Intraocular Melanoma; Stage IIB Melanoma; Stage IIC Melanoma; Stage IIIA Intraocular Melanoma; Stage IIIA Melanoma; Stage IIIB Intraocular Melanoma; Stage IIIB Melanoma; Stage IIIC Intraocular Melanoma; Stage IIIC Melanoma; Stage IV Intraocular Melanoma; Stage IV Melanoma

2014-09-23

118

Melanoma maligno conjuntival / Malignant melanoma of the conjunctiva  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: Os tumores melanocíticos conjuntivais compreendem lesões que podem variar desde lesões benignas como os nevos conjuntivais, lesões pré-cancerosas como melanose adquirida primária com atipia até o melanoma maligno conjuntival. O reconhecimento das características clinicas destas lesões e [...] seu diagnóstico preciso permitem o tratamento adequado, contribuindo para a redução da morbidade e mortalidade associados ao melanoma de conjuntiva. OBJETIVO: Revisão das características clinicas, diagnóstico e modalidades de tratamento clínico e cirúrgico das lesões precursoras (Nevos e melanose adquirida primária) e do maligno conjuntival. MÉTODOS: Revisão de literatura através de pesquisa no banco de dados MEDLINE, PUBMED, LILACS e SciELO no período de 1980 a 2011. As palavras-chave utilizadas, individualmente ou em conjunto, foram: "conjunctival melanoma", "primary acquired melanosis", "nevi", "treatment", "chemotherapy", "recurrence", "metastasis" e "mortality". RESULTADO: Características clínicas que permitem o diagnóstico do melanoma conjuntival e sua diferenciação de outras lesões pigmentadas conjuntivais foram consideradas. O estadiamento clínico e patológico, assim como modalidades de tratamento para o melanoma maligno foram revisadas. CONCLUSÕES: Pacientes portadores de lesões pigmentadas conjuntivais devem ser avaliados por um oftalmologista especialista. A história oftalmológica, a história familiar de melanoma, e características clínicas da lesão necessitam de cuidadosa avaliação, incluindo-se a determinação do risco de malignidade. A documentação fotográfica deve ser realizada. O tratamento clínico e planejamento cirúrgico devem ser baseados na suspeita clinica. A análise histopatológica por patologista experiente é fundamental para orientação do tratamento e para identificação de fatores prognósticos, principalmente em casos de doença maligna. Abstract in english INTRODUCTION: Melanocytic tumors comprise a wide range of lesions. These lesions can be nevi, primary acquired melanosis with or without atypia or malignant as conjunctival melanoma. Early recognition of the clinical features allows precise diagnosis and adequate intervention, reducing the rates of [...] metastatic disease and mortality associated with conjunctival melanoma. PURPOSE: To review clinical features, diagnosis, clinical and surgical treatment modalities of the different precursor pigmented lesions (Nevi and primary acquired melanosis) and malignant melanoma. METHODS: Literature review was performed accessing the database of MEDLINE, PUBMED, LILACS e SciELO between 1980 and 2011. The keywords used, individually or combined, were: conjunctival melanoma, primary acquired melanosis, nevi, treatment, chemotherapy, recurrence, metastasis e mortality. RESULTS: Relevant clinical information for the diagnosis of malignant melanoma and differentiation from other pigmented conjunctival lesions were accessed. Clinical and pathological features and different modalities of treatment for malignant melanoma have been reviewed. CONCLUSIONS: Patients presenting with a pigmented conjunctival lesion should be evaluated by an experienced ophthalmologist. Ocular history, family history of melanoma, and clinical features of the lesion need careful assessment and malignancy risk evaluation. Digital photo documentation should be performed. Clinical or surgical planning should be done based on the clinical suspicion. Careful histopathology analysis is required for treatment orientation and prognostic factors identification, mainly in cases of malignancy.

Gustavo Amorim, Novais; Carol Lynn, Karp.

2012-08-01

119

Melanoma maligno conjuntival Malignant melanoma of the conjunctiva  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUÇÃO: Os tumores melanocíticos conjuntivais compreendem lesões que podem variar desde lesões benignas como os nevos conjuntivais, lesões pré-cancerosas como melanose adquirida primária com atipia até o melanoma maligno conjuntival. O reconhecimento das características clinicas destas lesões e seu diagnóstico preciso permitem o tratamento adequado, contribuindo para a redução da morbidade e mortalidade associados ao melanoma de conjuntiva. OBJETIVO: Revisão das características clinicas, diagnóstico e modalidades de tratamento clínico e cirúrgico das lesões precursoras (Nevos e melanose adquirida primária e do maligno conjuntival. MÉTODOS: Revisão de literatura através de pesquisa no banco de dados MEDLINE, PUBMED, LILACS e SciELO no período de 1980 a 2011. As palavras-chave utilizadas, individualmente ou em conjunto, foram: "conjunctival melanoma", "primary acquired melanosis", "nevi", "treatment", "chemotherapy", "recurrence", "metastasis" e "mortality". RESULTADO: Características clínicas que permitem o diagnóstico do melanoma conjuntival e sua diferenciação de outras lesões pigmentadas conjuntivais foram consideradas. O estadiamento clínico e patológico, assim como modalidades de tratamento para o melanoma maligno foram revisadas. CONCLUSÕES: Pacientes portadores de lesões pigmentadas conjuntivais devem ser avaliados por um oftalmologista especialista. A história oftalmológica, a história familiar de melanoma, e características clínicas da lesão necessitam de cuidadosa avaliação, incluindo-se a determinação do risco de malignidade. A documentação fotográfica deve ser realizada. O tratamento clínico e planejamento cirúrgico devem ser baseados na suspeita clinica. A análise histopatológica por patologista experiente é fundamental para orientação do tratamento e para identificação de fatores prognósticos, principalmente em casos de doença maligna.INTRODUCTION: Melanocytic tumors comprise a wide range of lesions. These lesions can be nevi, primary acquired melanosis with or without atypia or malignant as conjunctival melanoma. Early recognition of the clinical features allows precise diagnosis and adequate intervention, reducing the rates of metastatic disease and mortality associated with conjunctival melanoma. PURPOSE: To review clinical features, diagnosis, clinical and surgical treatment modalities of the different precursor pigmented lesions (Nevi and primary acquired melanosis and malignant melanoma. METHODS: Literature review was performed accessing the database of MEDLINE, PUBMED, LILACS e SciELO between 1980 and 2011. The keywords used, individually or combined, were: conjunctival melanoma, primary acquired melanosis, nevi, treatment, chemotherapy, recurrence, metastasis e mortality. RESULTS: Relevant clinical information for the diagnosis of malignant melanoma and differentiation from other pigmented conjunctival lesions were accessed. Clinical and pathological features and different modalities of treatment for malignant melanoma have been reviewed. CONCLUSIONS: Patients presenting with a pigmented conjunctival lesion should be evaluated by an experienced ophthalmologist. Ocular history, family history of melanoma, and clinical features of the lesion need careful assessment and malignancy risk evaluation. Digital photo documentation should be performed. Clinical or surgical planning should be done based on the clinical suspicion. Careful histopathology analysis is required for treatment orientation and prognostic factors identification, mainly in cases of malignancy.

Gustavo Amorim Novais

2012-08-01

120

Melanoma mucoso de tabique nasal / Nasal cavity mucosal melanoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Los melanomas mucosos son tumores raros y de mal pronóstico. Representan alrededor del 1% del total de melanomas y el 0,5% de los tumores malignos de cabeza y cuello. Cuando se localiza en las fosas nasales, produce sintomatología tardía e inespecífica como obstrucción respiratoria, epistaxis o dolo [...] r facial. El tratamiento de elección es la cirugía combinada con quimio y radioterapia. Presentamos un caso con sobrevida de 4 años y realizamos una revisión de la literatura. Abstract in english Head and neck mucosal melanoma is a rare entity with poor prognosis. This tumour represents less than 1% of malignant melanomas and 0.5% of head and neck malignancies. Melanomas that arise in the nasal cavity present with non-specific symptoms and have a poor prognosis. Wide local excision is the tr [...] eatment of choice combined with postoperative chemoradiotherapy. We present a case with an unusual survival (4 years) and perform a review of the literature.

Luis, Sarra; Juan C., Rodríguez; Mariela, García-Valea; Aníbal, Arédez-Ferrer; Anabel, Vino; Bárbara, Guassardo.

 
 
 
 
121

Trabajo de revisión: melanoma / Work of revision: melanoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El melanoma maligno es derivado de células dendríticas (névicas) proliferantes progenitoras de lesiones. Son importantes en la histogénesis y en el riesgo de desarrollo del melanoma maligno. Del 30% al 37% de los melanomas malignos del tracto aero-digestivo superior están asociados a una lesión prem [...] aligna melanótica. Los hallazgos histopatológicos con técnicas convencionales concuerdan en considerar de valor el tamaño del tumor, las células atípicas, la distribución de las células y los márgenes de la lesión. Avances mayores en inmunología de los tumores, llevan a identificar la interacción célula tumoral- célula T. Han sido identificados y caracterizados molecularmente un número de melanomas asociados a antígenos. Abstract in english Advance malignant melanoma is generated from proliferating dendritic (nevic) cell progenitors. They are important on the histogenesis and risk of tumor development. From 30% to 37% from high air-digestic track melanoms, there are associated with premalignant cell dendritic lesions. Histophatological [...] approaches agree in consider size of tumor, atypical cells, distribution of this cells and borders of lesion as valued markers. Major advances in tumor irnmunology, have led to understand tumor cell-T cell interactions. A number of melanom associated antigens have been identified and molecularly characterized.

Z. J., Casariego; J. E., Baudo.

122

Particularities of melanoma in Romania  

International Nuclear Information System (INIS)

Full text: Malignant tumor from melanocytic origin, cutaneous melanoma is the most aggressive cutaneous cancer. The particularities of melanoma in Romania are: 1. the increasing number of cases in a geographic area dominated by the third cutaneous phototype; 2. the high level of T, represented by high levels of Breslow and Clark invasion markers; 3. the lack of a National Melanoma Register; 4. the lymph node sentinel biopsy technique introduction is the present focus; this allows an appropriate N affiliation; 5. the increasing of sanitary education in order to clinical and dermoscopical follow-up of atypical moles and the study of risk factors for melanoma; 6. the creation of a melanoma local guide. The survival prognosis could be improved by: a) the early detection in 'in situ' stage of melanoma and b) the correct TNM and/or EORTC affiliation of the case, in order to achieve an appropriate treatment. Sentinel lymph node detection and biopsy offers a new area in the evaluation of cancer spread by detecting micrometastases and performing a complete regional evaluation of the disease. The presence or absence of the metastases in the regional lymph nodes is one of the most important factors in the survival of patients with primary cutaneous melanoma. Early diagnosis of regional lymph node metastases enables the identification of those patients who are candidates for adjuvant therapy and early therapeutic lymph node dissection. At the same time, the sentinel node biopsy p the same time, the sentinel node biopsy procedure represents a sensitive staging method. The paper presents some of gold standard diagnosis cases, dermoscopy and routine HE examination, selected from a total of 356 cases. (author)

123

Polypoid melanoma and superficial spreading melanoma different subtypes in the same lesion  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Melanoma is a malignant melanocytic neoplasm with high mortality rate, and steadily and universally increasing incidence rates. Polypoid melanoma is considered an exophytic variant of the nodular subtype. The incidence of polypoid melanoma is extremely variable, most likely because of the different [...] criteria used for its characterization. We presented a rare case of polypoid melanoma and superficial spreading melanoma in the same lesion.

Renato Shintani, Hikawa; Eliza Sayuri, Kanehisa; Mílvia Maria Simões e Silva, Enokihara; Mauro Yoshiaki, Enokihara; Sérgio Henrique, Hirata.

124

Polypoid melanoma and superficial spreading melanoma different subtypes in the same lesion*  

Science.gov (United States)

Melanoma is a malignant melanocytic neoplasm with high mortality rate, and steadily and universally increasing incidence rates. Polypoid melanoma is considered an exophytic variant of the nodular subtype. The incidence of polypoid melanoma is extremely variable, most likely because of the different criteria used for its characterization. We presented a rare case of polypoid melanoma and superficial spreading melanoma in the same lesion. PMID:25054761

Hikawa, Renato Shintani; Kanehisa, Eliza Sayuri; Enokihara, Milvia Maria Simoes e Silva; Enokihara, Mauro Yoshiaki; Hirata, Sergio Henrique

2014-01-01

125

Oral and Cutaneous Melanoma: Similarities and Differences  

Science.gov (United States)

Melanomas are malignant lesions stemming from the disorganized proliferation of melanocytes. This condition is more common on skin, but may also be detected in mucosa, such as in the oral cavity. The aim of the present study was to report similarities and differences between oral and cutaneous melanoma. Keywords Melanoma; Skin; Mouth; Diagnosis PMID:21629531

Moreira, Rafaela Nogueira; Santos, Cassio Roberto Rocha; Lima, Nadia Lages; Verli, Flaviana Dornela; Marinho, Sandra Aparecida

2010-01-01

126

Melanoma vaccines: trials and tribulations  

Directory of Open Access Journals (Sweden)

Full Text Available Robert O Dillman1,21Hoag Cancer Institute and Hoag Institute for Research and Education, Newport Beach, CA, USA; 2University of California Irvine, Irvine, CA, USAAbstract: Metastatic melanoma has been a target of immunotherapy for more than 4 decades. Three immunotherapeutics have received regulatory approval for treating melanoma: interferon-alpha, interleukin-2, and ipilimumab. The antitumor mechanisms of these products depend on enhancing existing immune responses, including autoimmune effects. The combination of autologous, cytotoxic T-lymphocytes plus high-dose interleukin-2 is a promising patient-specific therapy, but has limited clinical application. Other approaches include vaccines targeting melanoma-associated antigens, and patient-specific vaccines that utilize autologous tumor. Non-patient-specific vaccine approaches target melanocyte differentiation antigens (eg, tyrosinase, Melan-A, gp100, antigens identified by cytotoxic T-lymphocytes (eg, NY-Eso-1, Melan-A/Mart-1, Mage-3, and antigens originally identified by murine monoclonal antibodies (gangliosides, gp97, gp225. Self-renewing cells in tumor cell lines may represent tumor stem cells, but vaccines derived from allogeneic tumor cell lines have yielded disappointing results in randomized trials. Patient-specific vaccines can be derived from bulk autologous tumor or autologous tumor cell lines, and intratumoral injections of immunostimulatory fusion products have shown promise. While technically more complex to manufacture, patient-specific vaccines derived from autologous tumor cell lines have the potential to target tumor stem cells and overcome interpatient tumor cell heterogeneity. This article reviews sources of melanoma-associated antigens, costimulatory agents, and clinical trial results for various melanoma vaccines. Comparing Phase II trials is difficult because of the wide range of vaccine strategies and the differences in study patient populations; therefore, randomized trials are necessary to prove the efficacy of such products. Therapeutic vaccines are more likely to enhance, rather than replace, other anti-melanoma immune therapies. In particular, effective vaccines may be synergistic with products that block T-cell immune checkpoint molecules such as ipilimumab and monoclonal antibodies that interfere with programmed death ligand-receptor interactions.Keywords: melanoma, vaccines, melanoma-associated antigens, melanoma stem cells, dendritic cells, GM-CSF, checkpoint molecules

Dillman RO

2013-10-01

127

MR imaging of malignant melanomas  

International Nuclear Information System (INIS)

We reviewed MR images of eight primary dermal malignant melanomas and 15 metastatic lesions in 12 patients and we correlated the findings with surgical and/or clinical findings. Signal intensity equivalent to that of subcutaneous fat was seen in 10 of 19 homogeneous lesions on T1 weighted images, which confirmed the paramagnetic property of the malignant melanoma. The surgical specimen of the primary lesions did not show significant intratumoral hemorrhage. This suggests that the paramagnetic property was present in the melanoma cells. However, low signal intensity on T2 WI which was reportedly characteristic to head and neck melanomas was observed only in three metastatic lesions, suggesting that lesions contained parts of hemorrhage or tissue degeneration. All the other lesions showed signal intensity equivalent to, or higher than that of subcutaneous fat. The long T2 values were supposed to be due to high water concentration in the lesions. MRI diagnosis of the extension of the primary lesions well correlated with the surgical findings. Three lesions were contained within the dermis and two had bone invasion. MRI proved to be useful in preoperative evaluation of the primary dermal malignant melanomas and assessment of the metastatic lesions. (author)

128

Hyperspectral imaging for melanoma screening  

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The 5-year survival rate for patients diagnosed with Melanoma, a deadly form of skin cancer, in its latest stages is about 15%, compared to over 90% for early detection and treatment. We present an imaging system and algorithm that can be used to automatically generate a melanoma risk score to aid clinicians in the early identification of this form of skin cancer. Our system images the patient's skin at a series of different wavelengths and then analyzes several key dermoscopic features to generate this risk score. We have found that shorter wavelengths of light are sensitive to information in the superficial areas of the skin while longer wavelengths can be used to gather information at greater depths. This accompanying diagnostic computer algorithm has demonstrated much higher sensitivity and specificity than the currently commercialized system in preliminary trials and has the potential to improve the early detection of melanoma.

Martin, Justin; Krueger, James; Gareau, Daniel

2014-03-01

129

Anal canal melanoma: Case report  

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Full Text Available Anal canal melanoma is a rare disease comprising 1% of all colorectal ie. anal malignant tumours with very poor long term prognosis. Its significant biologic aggressivity is the consequence of the tendency towards lymphatic, local and hematogenous spread. At the moment of diagnosis even 30% of the patients have distant metastases. Surgical intervention represents the only possibility for cure. Modern approach to the anal canal melanoma treatment implies two types of intervention: wide local excision preserving the sphincter mechanism and abdominoperineal resection of the rectum. There are numerous dilemmas about the choice of surgery in particular disease stages. The authors report on a 61 years old women in which anal canal melanoma with left inguinal lymphatic metastases was detected during the inspection of "haemorrhoids". After the diagnosis was established, abdominoperineal resection of the rectum was performed with dissection of both inguinal regions. .

Brankovi? B.

2006-01-01

130

[Primary digestive melanomas: is there any consensus?].  

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In clinical practice and the literature, malignant melanoma usually appears in typical sites where melanocytes can be found: skin, eyes meninges and anal region. Malignant melanomas of the esophagus-gastrointestinal (EGI) tract are usually metastatic. Primary and diffuse EGI tract melanoma is rare and only a few descriptions of this presentation have been found in the literature. The prognosis of EGI tract melanoma is frightening because of late diagnosis and high malignancy potential. Treatment is based essentially on surgery. The objective of the present study is to specify the clinical and therapeutic aspects of primary digestive melanoma. PMID:24977452

Eddekkaoui, Houda; Guy, Jean-Baptiste; Falk, Alexander T; Lahmar, Rima; Trone, Jane-Chloé; Bahadoor, Mohun R K; Kullab, Sharif; Collard, Olivier; Rivoirard, Romain; Moriceau, Guillaume; Vignot, Stéphane; Magné, Nicolas

2014-06-01

131

Metastatic melanoma of the stomach / Melanoma metastático do estômago  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese INTRODUCTION: O melanoma metastático do estômago é entidade relativamente rara e de diagnóstico incomum em vida. A cirurgia é o tratamento de escolha, pois alivia os sintomas em mais de 90% dos casos e aumenta a sobrevida a longo prazo. OBJETIVO: Relatar um caso de melanoma metastático do estômago, [...] submetida à ressecção curativa e que evoluiu sem sinais de doença residual. RELATO DO CASO: Mulher de 50 anos apresentou mancha escura em leito ungueal de dedo polegar de mão direita há dois anos, evoluindo com ulceração e sangramento. A biópsia diagnosticou neoplasia melanocítica ungueal compatíveis com melanoma lentiginoso e confirmado pela imunohistoquímica que apresentou células pigmentadas HMB-45 positivas. Após um ano e meio a paciente evoluiu com metástase de melanoma em coxa esquerda e extensa lesão escavada em pequena curvatura gástrica, cuja biopsia foi compatível com melanoma metastático do estômago. Hemograma com discreta anemia (Hb: 11,1 e Ht: 33%) e LDH: 333 U/L. A paciente foi submetida à gastrectomia total com reconstrução em Y de Roux. Houve boa evolução e no 6º dia de pós-operatório teve alta hospitalar. Atualmente, no 12º mês de seguimento, a paciente permanece sem queixas, com alívio completo dos sintomas e com todos os exames de controle normais. CONCLUSÃO: O tratamento cirúrgico deve ser sempre considerado no melanoma metastático do trato gastrointestinal, pois o procedimento possui baixa morbidade e mortalidade, além de proporcionar alívio dos sintomas com melhora da qualidade de vida e aumento da sobrevida a longo prazo. Abstract in english BACKGROUND: Metastatic melanoma of the stomach is a relatively rare entity with an unusual diagnosis during life. Surgery is the treatment of choice once it alleviates the symptoms in over 90% of the cases and increases the long-term survival. CASE REPORT: A 50y woman had presented a dark spot in th [...] e ungual bed of her right-hand thumb for two years, evolving into ulceration and bleeding. The biopsy diagnosed ungual malanocytic neoplasia compatible with lentiginous melanoma confirmed by immunohistochemistry, which presented positive pigmented HMB-45 cells. After an year and a half, the patient developed metastasis of the melanoma on her left thigh and extensive ulcerated lesion in the small gastric curvature, whose biopsy was compatible with metastatic melanoma of the stomach. The hemogram found discrete anemia (Hb: 11.1 and Ht: 33%) and LDH: 333 U/L. The patient underwent total gastrectomy with reconstruction in Roux-en-Y. There was a good evolution and on the 6th post-operative day, she was discharged home. At present, in the 12th month of follow up, the patient remains without complaints, with full relief of symptoms and all normal control exams. CONCLUSION: Surgical management should always be considered for the metastatic melanoma of the gastrointestinal tract, since the procedure shows low morbidity and mortality, besides providing relief of symptoms with the improvement of the quality of life and increase in the long-term survival.

Marcelo Eustáquio, Rocha; Gilberto Pedro, Rodrigues; Samir Almeida, Borges; Fernando Gusmão, Santiago.

132

Metastatic melanoma of the stomach Melanoma metastático do estômago  

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Full Text Available BACKGROUND: Metastatic melanoma of the stomach is a relatively rare entity with an unusual diagnosis during life. Surgery is the treatment of choice once it alleviates the symptoms in over 90% of the cases and increases the long-term survival. CASE REPORT: A 50y woman had presented a dark spot in the ungual bed of her right-hand thumb for two years, evolving into ulceration and bleeding. The biopsy diagnosed ungual malanocytic neoplasia compatible with lentiginous melanoma confirmed by immunohistochemistry, which presented positive pigmented HMB-45 cells. After an year and a half, the patient developed metastasis of the melanoma on her left thigh and extensive ulcerated lesion in the small gastric curvature, whose biopsy was compatible with metastatic melanoma of the stomach. The hemogram found discrete anemia (Hb: 11.1 and Ht: 33% and LDH: 333 U/L. The patient underwent total gastrectomy with reconstruction in Roux-en-Y. There was a good evolution and on the 6th post-operative day, she was discharged home. At present, in the 12th month of follow up, the patient remains without complaints, with full relief of symptoms and all normal control exams. CONCLUSION: Surgical management should always be considered for the metastatic melanoma of the gastrointestinal tract, since the procedure shows low morbidity and mortality, besides providing relief of symptoms with the improvement of the quality of life and increase in the long-term survival.INTRODUCTION: O melanoma metastático do estômago é entidade relativamente rara e de diagnóstico incomum em vida. A cirurgia é o tratamento de escolha, pois alivia os sintomas em mais de 90% dos casos e aumenta a sobrevida a longo prazo. OBJETIVO: Relatar um caso de melanoma metastático do estômago, submetida à ressecção curativa e que evoluiu sem sinais de doença residual. RELATO DO CASO: Mulher de 50 anos apresentou mancha escura em leito ungueal de dedo polegar de mão direita há dois anos, evoluindo com ulceração e sangramento. A biópsia diagnosticou neoplasia melanocítica ungueal compatíveis com melanoma lentiginoso e confirmado pela imunohistoquímica que apresentou células pigmentadas HMB-45 positivas. Após um ano e meio a paciente evoluiu com metástase de melanoma em coxa esquerda e extensa lesão escavada em pequena curvatura gástrica, cuja biopsia foi compatível com melanoma metastático do estômago. Hemograma com discreta anemia (Hb: 11,1 e Ht: 33% e LDH: 333 U/L. A paciente foi submetida à gastrectomia total com reconstrução em Y de Roux. Houve boa evolução e no 6º dia de pós-operatório teve alta hospitalar. Atualmente, no 12º mês de seguimento, a paciente permanece sem queixas, com alívio completo dos sintomas e com todos os exames de controle normais. CONCLUSÃO: O tratamento cirúrgico deve ser sempre considerado no melanoma metastático do trato gastrointestinal, pois o procedimento possui baixa morbidade e mortalidade, além de proporcionar alívio dos sintomas com melhora da qualidade de vida e aumento da sobrevida a longo prazo.

Marcelo Eustáquio Rocha

2008-12-01

133

Metastatic melanoma of the gallbladder.  

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We report the findings of a magnetic resonance (MR) imaging analysis of metastatic melanoma of the gallbladder in a 36-year-old woman. MR imaging revealed that the gallbladder wall was diffusely thickened, and the tumor showed slightly high-intensity on T1-weighted images. The apparent diffusion coefficient value of the tumor was 0.69 x 10(-3)mm(2)/s, indicating high cellularity. Surgical specimens revealed that the tumor was a metastatic melanoma showing medullary growth with intratumoral hemorrhaging. These MR findings are helpful for preoperative diagnosis. PMID:17517496

Takayama, Yukihisa; Asayama, Yoshiki; Yoshimitsu, Kengo; Irie, Hiroyuki; Tajima, Tsuyoshi; Hirakawa, Masakazu; Ishigami, Kousei; Kakihara, Daisuke; Sugitani, Atsushi; Moroi, Yoichi; Eguchi, Takashi; Honda, Hiroshi

2007-09-01

134

CT and MRI manifestations of intracranial melanomas  

International Nuclear Information System (INIS)

Objective: To explore the CT and MR imaging characteristics of intracranial melanomas. Methods: CT and MRI characteristics in five patients admitted to our hospital from June 1993 to June 2000 and diagnosed as intracranial melanomas were retrospectively analyzed. Results: There were two cases of primary melanoma and three cases of secondary melanoma. All the cases were examined by CT. The lesions presented as high density in 4 cases, and low density in only 1 case. Four cases were examined by MRI. Short T1 and short T2 signals were found in 3 cases, and slightly long T1 and short T2 signal was found in 1 case. Conclusion: There are some special characteristics of melanomas on the MR imaging, which are helpful to ensure the diagnosis and distinguish the primary melanomas from secondary melanomas

135

Amelanotic metastatic cutaneous melanoma / Melanoma metastático amelanótico cutâneo  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese A dermatoscopia das lesões melanocíticas tem auxiliado na decisão de biopsiar ou não uma lesão. A utilização desta ferramenta aumentou a sensibilidade e a especificidade do diagnóstico para 89% e 96%, respectivamente. No entanto, a avaliação dermatoscópica de melanomas amelanóticos ou hipomelanótico [...] s, bem como a de metástases cutâneas, pode ser difícil. Ainda falta uma padronização para a análise destas patologias, que se baseia, majoritariamente, no seu padrão vascular. Descreve-se a dermatoscopia de melanoma metastático amelanótico acral. Abstract in english Dermatoscopy of melanocytic lesions has guided the decision of when or not to biopsy a lesion. The use of this tool has increased clinical examination's sensitivity and specificity in 89% and 96% respectively. However, dermatoscopic evaluation of amelanotic or hypomelanotic melanomas, as well as met [...] astases, can be difficult. There is still no standardization for the analysis of these pathologies, which relies mostly on their vascular pattern. We describe the dermatoscopy of acral metastatic amelanotic melanoma.

Marcela Sena Teixeira, Mendes; Mariana Carvalho, Costa; Ciro Martins, Gomes; Lisley Calixto de, Araújo; Gustavo Henrique Soares, Takano.

136

UVB: suscetibilidade no melanoma maligno / UVB: susceptibility in malignant melanoma  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTOS: Está bem definido que a radiação ultravioleta provoca depleção imunológica na pele, permitindo o desenvolvimento de tumores cutâneos malignos. A maioria dos pacientes de cânceres da pele não melanomas são considerados UVB-suscetíveis. OBJETIVOS: Estudar a UVB-suscetibilidade nos pacient [...] es com melanoma maligno e se este é um fator de risco para o desenvolvimento desse câncer. MÉTODOS: Foram selecionados 88 voluntários divididos em dois grupos: grupo-controle saudável (n=61) e grupo de portadores de melanoma (n=27), todos identificados de acordo com os critérios: tipo histológico, nível de invasão, fotótipos de pele, sexo e idade. A suscetibilidade à radiação ultravioleta B (UVB) foi medida pela reação de hipersensibilidade ao contato com o difenciprone nos voluntários sensibilizados em áreas previamente irradiadas. RESULTADOS: A suscetibilidade à radiação UVB foi de 81,5% nos pacientes com melanoma maligno e de 31,2% no grupo-controle. O risco de um indivíduo desenvolver o melanoma maligno foi 9,7 vezes maior do que nos indivíduos UVB-resistentes. CONCLUSÕES: A UVB-suscetibilidade pode ser considerada um fator de risco importante para o desenvolvimento do melanoma maligno. Abstract in english BACKGROUND: It is well established that UV radiation provokes an immunological depletion in the skin, enabling the development of malignant cutaneous tumors. Most nonmelanoma skin cancer patients are considered to be UVB-susceptible. OBJECTIVE: To study the behavior of UVB- susceptibility in maligna [...] nt melanoma (MM) patients and whether this is a risk factor to the development of MM. METHODS: Eighty-eight volunteers were selected and divided into two groups: healthy control group (n = 61) and MM group (n = 27), which were identified according to the following clinical criteria: histopathological type, level of invasion, skin phototype, sex and age. Susceptibility to ultraviolet B (UVB) radiation was measured by the onset of a contact hypersensitivity reaction to diphenylcyclopropenone among individuals sensitized in previously irradiated areas. RESULTS: Susceptibility to UVB radiation was 81.5 in the MM group and 31.2% in the control group. The risk of an UVB-susceptible individual to develop MM was 9.7 times higher than when UVB resistant. CONCLUSION: UVB susceptibility should be considered an important risk factor to the development of this type of cancer.

Nilton, Nasser.

137

UVB: suscetibilidade no melanoma maligno / UVB: susceptibility in malignant melanoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTOS: Está bem definido que a radiação ultravioleta provoca depleção imunológica na pele, permitindo o desenvolvimento de tumores cutâneos malignos. A maioria dos pacientes de cânceres da pele não melanomas são considerados UVB-suscetíveis. OBJETIVOS: Estudar a UVB-suscetibilidade nos pacient [...] es com melanoma maligno e se este é um fator de risco para o desenvolvimento desse câncer. MÉTODOS: Foram selecionados 88 voluntários divididos em dois grupos: grupo-controle saudável (n=61) e grupo de portadores de melanoma (n=27), todos identificados de acordo com os critérios: tipo histológico, nível de invasão, fotótipos de pele, sexo e idade. A suscetibilidade à radiação ultravioleta B (UVB) foi medida pela reação de hipersensibilidade ao contato com o difenciprone nos voluntários sensibilizados em áreas previamente irradiadas. RESULTADOS: A suscetibilidade à radiação UVB foi de 81,5% nos pacientes com melanoma maligno e de 31,2% no grupo-controle. O risco de um indivíduo desenvolver o melanoma maligno foi 9,7 vezes maior do que nos indivíduos UVB-resistentes. CONCLUSÕES: A UVB-suscetibilidade pode ser considerada um fator de risco importante para o desenvolvimento do melanoma maligno. Abstract in english BACKGROUND: It is well established that UV radiation provokes an immunological depletion in the skin, enabling the development of malignant cutaneous tumors. Most nonmelanoma skin cancer patients are considered to be UVB-susceptible. OBJECTIVE: To study the behavior of UVB- susceptibility in maligna [...] nt melanoma (MM) patients and whether this is a risk factor to the development of MM. METHODS: Eighty-eight volunteers were selected and divided into two groups: healthy control group (n = 61) and MM group (n = 27), which were identified according to the following clinical criteria: histopathological type, level of invasion, skin phototype, sex and age. Susceptibility to ultraviolet B (UVB) radiation was measured by the onset of a contact hypersensitivity reaction to diphenylcyclopropenone among individuals sensitized in previously irradiated areas. RESULTS: Susceptibility to UVB radiation was 81.5 in the MM group and 31.2% in the control group. The risk of an UVB-susceptible individual to develop MM was 9.7 times higher than when UVB resistant. CONCLUSION: UVB susceptibility should be considered an important risk factor to the development of this type of cancer.

Nilton, Nasser.

2010-12-01

138

UVB: suscetibilidade no melanoma maligno UVB: susceptibility in malignant melanoma  

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Full Text Available FUNDAMENTOS: Está bem definido que a radiação ultravioleta provoca depleção imunológica na pele, permitindo o desenvolvimento de tumores cutâneos malignos. A maioria dos pacientes de cânceres da pele não melanomas são considerados UVB-suscetíveis. OBJETIVOS: Estudar a UVB-suscetibilidade nos pacientes com melanoma maligno e se este é um fator de risco para o desenvolvimento desse câncer. MÉTODOS: Foram selecionados 88 voluntários divididos em dois grupos: grupo-controle saudável (n=61 e grupo de portadores de melanoma (n=27, todos identificados de acordo com os critérios: tipo histológico, nível de invasão, fotótipos de pele, sexo e idade. A suscetibilidade à radiação ultravioleta B (UVB foi medida pela reação de hipersensibilidade ao contato com o difenciprone nos voluntários sensibilizados em áreas previamente irradiadas. RESULTADOS: A suscetibilidade à radiação UVB foi de 81,5% nos pacientes com melanoma maligno e de 31,2% no grupo-controle. O risco de um indivíduo desenvolver o melanoma maligno foi 9,7 vezes maior do que nos indivíduos UVB-resistentes. CONCLUSÕES: A UVB-suscetibilidade pode ser considerada um fator de risco importante para o desenvolvimento do melanoma maligno.BACKGROUND: It is well established that UV radiation provokes an immunological depletion in the skin, enabling the development of malignant cutaneous tumors. Most nonmelanoma skin cancer patients are considered to be UVB-susceptible. OBJECTIVE: To study the behavior of UVB- susceptibility in malignant melanoma (MM patients and whether this is a risk factor to the development of MM. METHODS: Eighty-eight volunteers were selected and divided into two groups: healthy control group (n = 61 and MM group (n = 27, which were identified according to the following clinical criteria: histopathological type, level of invasion, skin phototype, sex and age. Susceptibility to ultraviolet B (UVB radiation was measured by the onset of a contact hypersensitivity reaction to diphenylcyclopropenone among individuals sensitized in previously irradiated areas. RESULTS: Susceptibility to UVB radiation was 81.5 in the MM group and 31.2% in the control group. The risk of an UVB-susceptible individual to develop MM was 9.7 times higher than when UVB resistant. CONCLUSION: UVB susceptibility should be considered an important risk factor to the development of this type of cancer.

Nilton Nasser

2010-12-01

139

Quem descobre o melanoma cutâneo / Who discovers the cutaneous melanoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTO: No Brasil não se sabe quem descobre os casos de melanoma cutâneo. A compreensão dos "modelos de descoberta" poderia servir de base para os programas de educação pública e do profissional de saúde. OBJETIVO: Determinar o papel dos pacientes em encontrar suas próprias lesões. MÉTODOS: Fora [...] m entrevistados 109 pacientes com diagnóstico anterior de melanoma cutâneo, acompanhados na Unidade de Melanoma da Santa Casa de Misericórdia de São Paulo. Outras variáveis foram anotadas para avaliar suas possíveis influências no resultado da descoberta: sexo, idade, estado civil, escolaridade, antecedente familiar de melanoma, localização da lesão primária e conhecimento sobre câncer da pele. RESULTADOS: Dos 109 pacientes, 59 (54%) notaram a própria lesão. Deles, 62% eram mulheres, 51% menores de 60 anos, 90% sem antecedentes familiares de melanoma, 78% negavam conhecimento sobre câncer de pele, 59% eram casados, 52% cursaram apenas a escola primária. Os demais 50 pacientes tiveram sua lesão descoberta em 24% dos casos por profissionais de saúde, 10% pela esposa, 1% pelo marido e 11% por outras pessoas. CONCLUSÃO: 54% dos pacientes notaram sua própria lesão, que em cerca de 25% foi descoberta por leigos. Esses resultados são semelhantes aos da literatura dos países desenvolvidos. A clientela avaliada foi do tipo assistencial, e com esse resultado é possível acreditar que, no Brasil, alguma influência das campanhas públicas de saúde já pode ser notada. Abstract in english BACKGROUND - In Brazil, it is still unknown who first discovers the cases of cutaneous melanoma. The understanding of our “finding patterns” could be used as a basis for public education programs and healthcare professional training. OBJECTIVE - To determine the role of patients in detecting lesions [...] by themselves. METHODS - One hundred and nine patients were interviewed. The patients had a diagnosis of cutaneous melanoma and were regularly seen at the Melanoma Unit of Hospital Santa Casa de Misericórdia, in São Paulo. Other variables were considered to evaluate possible influences in the results: sex, age, marital status, schooling, family history of melanoma, site of the primary lesion and knowledge about skin cancer. RESULTS - Out of 109 interviewed patients, 54% had the lesion detected by themselves. Of those, 62% were female, 51% were aged under 60 years, 90% had no family history of melanoma, 78% had no knowledge about skin cancer, 59% were married and 52% concluded up to primary education. Out of the remaining 50 patients, 24% had their lesions detected by health professionals, 10% by their wives, 1% by their husbands and 11% by other people. CONCLUSION - Fifty-four percent of patients detected the lesion by themselves, and roughly 25% had the lesion detected by a lay person. These results are similar to those reported in the literature of developed countries. The clientele evaluated is attended by public healthcare services and the results lead to the conclusion that some influence of public health campaigns could already be noticed in Brazil.

Marcus, Maia; Marianne, Basso.

2006-06-01

140

Quem descobre o melanoma cutâneo / Who discovers the cutaneous melanoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTO: No Brasil não se sabe quem descobre os casos de melanoma cutâneo. A compreensão dos "modelos de descoberta" poderia servir de base para os programas de educação pública e do profissional de saúde. OBJETIVO: Determinar o papel dos pacientes em encontrar suas próprias lesões. MÉTODOS: Fora [...] m entrevistados 109 pacientes com diagnóstico anterior de melanoma cutâneo, acompanhados na Unidade de Melanoma da Santa Casa de Misericórdia de São Paulo. Outras variáveis foram anotadas para avaliar suas possíveis influências no resultado da descoberta: sexo, idade, estado civil, escolaridade, antecedente familiar de melanoma, localização da lesão primária e conhecimento sobre câncer da pele. RESULTADOS: Dos 109 pacientes, 59 (54%) notaram a própria lesão. Deles, 62% eram mulheres, 51% menores de 60 anos, 90% sem antecedentes familiares de melanoma, 78% negavam conhecimento sobre câncer de pele, 59% eram casados, 52% cursaram apenas a escola primária. Os demais 50 pacientes tiveram sua lesão descoberta em 24% dos casos por profissionais de saúde, 10% pela esposa, 1% pelo marido e 11% por outras pessoas. CONCLUSÃO: 54% dos pacientes notaram sua própria lesão, que em cerca de 25% foi descoberta por leigos. Esses resultados são semelhantes aos da literatura dos países desenvolvidos. A clientela avaliada foi do tipo assistencial, e com esse resultado é possível acreditar que, no Brasil, alguma influência das campanhas públicas de saúde já pode ser notada. Abstract in english BACKGROUND - In Brazil, it is still unknown who first discovers the cases of cutaneous melanoma. The understanding of our “finding patterns” could be used as a basis for public education programs and healthcare professional training. OBJECTIVE - To determine the role of patients in detecting lesions [...] by themselves. METHODS - One hundred and nine patients were interviewed. The patients had a diagnosis of cutaneous melanoma and were regularly seen at the Melanoma Unit of Hospital Santa Casa de Misericórdia, in São Paulo. Other variables were considered to evaluate possible influences in the results: sex, age, marital status, schooling, family history of melanoma, site of the primary lesion and knowledge about skin cancer. RESULTS - Out of 109 interviewed patients, 54% had the lesion detected by themselves. Of those, 62% were female, 51% were aged under 60 years, 90% had no family history of melanoma, 78% had no knowledge about skin cancer, 59% were married and 52% concluded up to primary education. Out of the remaining 50 patients, 24% had their lesions detected by health professionals, 10% by their wives, 1% by their husbands and 11% by other people. CONCLUSION - Fifty-four percent of patients detected the lesion by themselves, and roughly 25% had the lesion detected by a lay person. These results are similar to those reported in the literature of developed countries. The clientele evaluated is attended by public healthcare services and the results lead to the conclusion that some influence of public health campaigns could already be noticed in Brazil.

Marcus, Maia; Marianne, Basso.

 
 
 
 
141

Quem descobre o melanoma cutâneo Who discovers the cutaneous melanoma  

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Full Text Available FUNDAMENTO: No Brasil não se sabe quem descobre os casos de melanoma cutâneo. A compreensão dos "modelos de descoberta" poderia servir de base para os programas de educação pública e do profissional de saúde. OBJETIVO: Determinar o papel dos pacientes em encontrar suas próprias lesões. MÉTODOS: Foram entrevistados 109 pacientes com diagnóstico anterior de melanoma cutâneo, acompanhados na Unidade de Melanoma da Santa Casa de Misericórdia de São Paulo. Outras variáveis foram anotadas para avaliar suas possíveis influências no resultado da descoberta: sexo, idade, estado civil, escolaridade, antecedente familiar de melanoma, localização da lesão primária e conhecimento sobre câncer da pele. RESULTADOS: Dos 109 pacientes, 59 (54% notaram a própria lesão. Deles, 62% eram mulheres, 51% menores de 60 anos, 90% sem antecedentes familiares de melanoma, 78% negavam conhecimento sobre câncer de pele, 59% eram casados, 52% cursaram apenas a escola primária. Os demais 50 pacientes tiveram sua lesão descoberta em 24% dos casos por profissionais de saúde, 10% pela esposa, 1% pelo marido e 11% por outras pessoas. CONCLUSÃO: 54% dos pacientes notaram sua própria lesão, que em cerca de 25% foi descoberta por leigos. Esses resultados são semelhantes aos da literatura dos países desenvolvidos. A clientela avaliada foi do tipo assistencial, e com esse resultado é possível acreditar que, no Brasil, alguma influência das campanhas públicas de saúde já pode ser notada.BACKGROUND - In Brazil, it is still unknown who first discovers the cases of cutaneous melanoma. The understanding of our “finding patterns” could be used as a basis for public education programs and healthcare professional training. OBJECTIVE - To determine the role of patients in detecting lesions by themselves. METHODS - One hundred and nine patients were interviewed. The patients had a diagnosis of cutaneous melanoma and were regularly seen at the Melanoma Unit of Hospital Santa Casa de Misericórdia, in São Paulo. Other variables were considered to evaluate possible influences in the results: sex, age, marital status, schooling, family history of melanoma, site of the primary lesion and knowledge about skin cancer. RESULTS - Out of 109 interviewed patients, 54% had the lesion detected by themselves. Of those, 62% were female, 51% were aged under 60 years, 90% had no family history of melanoma, 78% had no knowledge about skin cancer, 59% were married and 52% concluded up to primary education. Out of the remaining 50 patients, 24% had their lesions detected by health professionals, 10% by their wives, 1% by their husbands and 11% by other people. CONCLUSION - Fifty-four percent of patients detected the lesion by themselves, and roughly 25% had the lesion detected by a lay person. These results are similar to those reported in the literature of developed countries. The clientele evaluated is attended by public healthcare services and the results lead to the conclusion that some influence of public health campaigns could already be noticed in Brazil.

Marcus Maia

2006-06-01

142

[Mandibular metastasis of a cutaneous melanoma or metachronous amelanotic melanoma of the oral cavity? A case report and literature review].  

Science.gov (United States)

Primary and metastatic mandibular melanoma are extremely rare. We report the original case of a 55-year-old woman treated 16 years before for a cutaneous melanoma, and now presenting with a huge mandibular amelanotic melanoma. Was it an histologically different mandibular metastasis of the previous cutaneous melanoma, or a metachronous oral amelanotic melanoma? PMID:24503521

Vierne, C; Hardy, H; Guichard, B; Barat, M; Péron, J-M; Trost, O

2014-08-01

143

What Is Melanoma Skin Cancer?  

Science.gov (United States)

... treated in different ways. Most non-melanoma skin cancers are basal cell or squamous cell cancers. They are by far the most common skin ... are more common than any other form of cancer. Because they rarely spread ... of the body, basal cell and squamous cell skin cancers are usually less ...

144

Rare variants of malignant melanoma.  

Science.gov (United States)

The personal experience with 5 rare types of malignant melanoma is reviewed to point out some of the practical problems in the diagnosis and management of these tumors. The rare forms discussed are conjunctival, nasal, oral, vulvar, and penile melanomas. All pigmented lesions in the oral cavity, but not the penis or vulva, should be prophylactically excised as lesions in the mouth have a higher malignant potential. Local excision of all 5 forms of primary melanomas, no matter how locally advanced they may be, is the sole treatment. Nevertheless, anatomic constraints often preclude surgery with generous margins and consequently local recurrence, particularly for conjunctival, nasal, and oral primary lesions, is usually the major first failure in treatment. Lymph node dissection is only performed if the regional nodes are palpable at the time of first presentation. Elective lymph node dissections are not performed since the patients are often elderly, the lymphatic drainage is usually ambiguous or multiple, and the disease tends to spread hematogenously rather than lymphatically. Surgery still remains the cornerstone of treatment for these rare forms of melanoma but prognosis is very poor since surgery is often a palliative rather than a curative measure. Improved survival may depend on identifying more effective chemotherapeutic and immunologic agents. PMID:1561796

Milton, G W; Shaw, H M

1992-01-01

145

Melanoma immunoediting by NK cells  

Science.gov (United States)

The immune system can control the early steps of tumor growth, but it may also induce phenotypic/functional changes of malignant cells during tumor progression, favoring immunoescape mechanisms. In a recent study, we revealed how natural killer (NK) cells can participate in such an immunoediting process, by rendering melanoma cells resistant to NK-mediated killing. PMID:23264909

Balsamo, Mirna; Pietra, Gabriella; Vermi, William; Moretta, Lorenzo; Mingari, Maria Cristina; Vitale, Massimo

2012-01-01

146

Skin Cancer Non-Melanoma  

Medline Plus

Full Text Available X-Plain Skin Cancer Non-Melanoma Reference Summary Introduction Each year, millions of people find out that ... 1995-2010, The Patient Education Institute, Inc. www.X-Plain.com oc180105 Last reviewed: 11/3/2010 ...

147

Cutaneous melanoma in solid organ transplant patients.  

Science.gov (United States)

Solid organ transplant patients are at greatly increased risk of developing a wide variety of skin cancers, particularly epithelial skin cancers. On the other hand, it is well known that an intact immune system limits the development of benign melanocytic lesions. The eruptive nevi phenomenon, which we can observe in solid organ transplant recipients, is indicative of the relationship between melanocyte proliferation and immune system. Regression of melanocytic nevi after restoration of complete immune responsiveness is a further clinical example the role of immunosurveillance on melanocyte proliferation. However, melanoma incidence in organ transplant recipients appears only 2-3 folds higher than in general population. To this regard, organ transplant recipients who develop de novo melanomas thicker than 2mm seem to have a significantly worse outcome with a greatly increased risk of dying of metastatic melanoma, whereas those who develop a ?2 mm thickness melanoma seem to have a prognosis similar to that of the general population. Furthermore, there is no evidence supporting an increased risk of melanoma recurrences after transplant in patients with a history of low-risk melanoma. Melanoma is also one of the most frequent and lethal donor-derived malignancies suggesting that a history of invasive melanoma should be considered an absolute contraindication to donation. The aim of this review is to investigate the relationship between immunosuppression and melanoma and to discuss its clinical implications for the management of transplant-associated melanoma. PMID:25068225

Russo, I; Piaserico, S; Belloni-Fortina, A; Alaibac, M

2014-08-01

148

Desmoplastic Melanoma: Report of 5 Cases  

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Full Text Available Background. The clinical presentation of desmoplastic melanoma is often challenging. We report the experience of the Melanoma Unit of Spedali Civili University Hospital of Brescia, Italy. Method. Study subjects were drawn from 1770 patients with histologica confirmed melanoma. Within this group, desmoplastic melanoma developed in 5 patients. For each diagnosed melanoma, histological characteristics, treatment, and outcomes were evaluated. Results. Of the 5 patients described in this study, 2 were males and 3 females. The average age was 62.4 years ranging from 56 to 68 years. Breslow thickness ranged from 2.1 to 12?mm with a mean thickness of 5.8?mm. Primary treatment of 5 patients included a wide local excision of their primary lesions. Conclusions. Desmoplastic melanoma is a rare neoplasm which clinically may mimic other tumours or cutaneous infiltrate of uncertain significance. The diagnosis is hiastopathological and radical resection is necessary.

A. M. Manganoni

2009-01-01

149

Aberrant DNA methylation in malignant melanoma  

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Malignant Melanoma remains one of the most deadly human cancers with no effective cures for metastatic disease. The poor efficacy of current therapy in advanced melanoma highlights the need for better understanding of molecular mechanisms contributing to the disease. Recent work has shown that epigenetic changes, including aberrant DNA methylation, lead to alterations in gene expression and are as important in the development of malignant melanoma as the specific and well characterized genetic events. Reversion of these methylation patterns could thus lead to a more targeted therapy and are currently under clinical investigation. The purpose of this review is to compile recent information on aberrant DNA methylation of melanoma, to highlight key genes and molecular pathways in melanoma development that have found to be epigenetically altered and to provide insight as of how DNA methylation might serve as targeted treatment option as well as a molecular and prognostic marker in malignant melanoma. PMID:20418788

Schinke, Carolina; Mo, Yongkai; Yu, Yiting; Amiri, Kathy; Sosman, Jeff; Greally, John; Verma, Amit

2010-01-01

150

Comedo-like openings in melanoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english We describe a case of melanoma with the presence of comedo-like openings at dermoscopy. These structures, typical of seborrheic keratosis, represent an uncommon finding in melanoma. We emphasize the importance of searching for specific dermoscopic criteria for melanocytic lesions during the examinat [...] ion of a pigmented lesion, despite possible observations of characteristic structures of non-melanocytic lesions, in order to increase the accuracy in the diagnosis of melanoma.

Bruno Simão dos, Santos; Lucia Helena Soares, Ribeiro; Eloisa Leis, Ayres; Enoi Aparecida Guedes, Vilar.

151

Malignant melanoma of the mandibular gingiva  

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Full Text Available Oral malignant melanoma is an infrequent neoplasia making up less than 1% of all melanomas, which exhibits much more aggressive behavior than those found on the skin. We present an aggressive case of oral malignant melanoma located on the mandibular gingiva in a 24-year-old male patient, who developed metastases to not only the regional lymph nodes but also the lungs and liver. The advanced stage of the disease contraindicated any surgical intervention and palliative chemotherapy was planned.

Manjunatha M. Revanappa

2010-06-01

152

Malignant melanomas of the head and neck  

International Nuclear Information System (INIS)

Twelve patients with malignant melanoma of the head and neck were treated in the Medical Academy of Warsaw. The largest group (8 patients) consisted of the cases with melanoma localized on the nasal mucosa. In next 4 patients the tumor localized on the skin of the head. The clinical course of the melanoma was discussed and its methods of cure (surgery and radiotherapy) in dependence on the degree of progression. (author)

153

Delving into somatic variation in sporadic melanoma  

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Melanoma, the most aggressive form of skin cancer, has increased in incidence more rapidly than any other cancer. The completion of the human genome project and advancements in genomics technologies has allowed us to investigate genetic alterations of melanoma at a scale and depth that is unprecedented. Here, we survey the history of the different approaches taken to understand the genomics of melanoma – from early candidate genes, to gene families, to genome-wide studies. The new era of wh...

Walia, Vijay; Mu, Euphemia W.; Lin, Jimmy C.; Samuels, Yardena

2012-01-01

154

[Primary malignant melanoma of the female urethra].  

Science.gov (United States)

Primary malignant melanoma of the genitourinary tract is rare and accounts for less than 1 per cent of all melanomas. The most frequent locations in male are penis and urethra. The most frequent site in female is urethra and it most commonly affects meatus and the distal urethra. The prognosis is poor. We report a patient with primary malignant melanoma of the female urethra. Clinicopathologic features and treatment of this tumor are discussed. PMID:10437350

Markovi?-Puac, L; Relji?, A; Kruslin, B

1999-03-01

155

Melanoma of unknown origin: a case series.  

LENUS (Irish Health Repository)

The natural history of metastatic melanoma involving lymph nodes, in the absence of a known primary site (cutaneous, ocular or mucosal) has, to date, been poorly defined; and the optimal management of this rare subtype of disease is therefore unclear. Melanomas of unknown primary site (MUP) are estimated to comprise between 3.7 and 6% of all melanomas (Anbari et al. in Cancer 79:1861-1821, 1997).

Kelly, J

2010-12-01

156

Giant hanging melanoma of the eyelid skin  

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Full Text Available Cutaneous melanoma of the eyelid is a rare entity. We present a 53-year-old male who had a nevus on the left upper eyelid skin since childhood, which transformed into a huge ulcerated hanging mass in the same region. Excision of the mass was done and histopathology confirmed the diagnosis of nodular malignant melanoma. A small preauricular lymph node showed metastatic melanoma on fine needle aspiration cytology.

Pai Radha

2008-01-01

157

Dermatoscopy of amelanotic and hypomelanotic melanoma.  

Science.gov (United States)

Amelanotic melanoma is a subtype of cutaneous melanoma without pigment. The clinical diagnosis is challenging because it may mimic benign or malignant melanocytic and non-melanocytic neoplasms and inflammatory skin diseases. In synchrony with the improvement of the diagnosis of pigmented lesions, dermatoscopy may assist the clinician in the diagnosis of non-pigmented skin neoplasms in general and of amelanotic melanoma in particular. We have searched the literature to extract the most relevant dermatoscopic clues to diagnose amelanotic and hypomelanotic melanomas by dermatoscopy. In addition we present eight consecutive cases and discuss their clinical and dermatoscopic characteristics in the light of published data. PMID:24825465

Stojkovic-Filipovic, Jelena; Kittler, Harald

2014-06-01

158

Laser radiation therapy of skin melanoma  

International Nuclear Information System (INIS)

Pulsed neodymium laser radiation was used for the treatment of 79 patients with cutaneous melanomas and 19 patients with melanoma metastases to the skin. The patients were followed up from 3 months up to 8 years. During this period local recurrences were detected in 2 cases. Out of 70 patients with cutaneous melanomas, who by the start of the treatment had no metastases in the regional lymph nodes or distant organs, metastases developed in 15 patients (21.4%). There are all reasons to consider pulsed laser radiation an effective means of treatment of some forms of skin melanoma. (orig.)

159

MR imaging of intracranial metastatic melanoma  

International Nuclear Information System (INIS)

Intracranial melanoma is an ideal lesion to study with MR imaging because of the inherent paramagnetic effect of free radicals known to exist in melanin. Nine patients with intracerebral metastases from cutaneous malignant melanoma were evaluated with spin-echo MR at 1.5 T and CT. Correlations were made with histopathologic findings. The unique MR appearance of intracranial melanoma enables separation of melanotic tumor from amelanotic tumor and from hemorrhage in certain cases. MR appears to be superior to CT in identifying and characterizing intracranial melanoma metastases and for following these lesions

160

Eye melanoma ion beam therapy  

International Nuclear Information System (INIS)

Conservative treatment of eye melanoma includes brachytherapy with different radioactive sources, transscleral local resection, transpupillary thermotherapy, leaser photocoagulation, and external particle radiotherapy. Proton beam therapy of eye melanoma offers the ideal physical properties to deliver apricise and homogeneous dose distribution within the target volume, with preservation of sensitive normal tissues due to the distal fall-off of the dose beyond the spread-out Bragg peak. Treatment of ocular tumors began on 1978 at National Institute of Radiological Sciences (NIRS). This paper focuses on the irradiation technique and the factors affecting the survival and metastatic rate. Information on local control, enucleation rate, and the visual outcome of those patients are also given. (author)

 
 
 
 
161

Neutron capture therapy for melanoma  

International Nuclear Information System (INIS)

The development of boron-containing compounds which localize selectively in tumor may require a tumor-by-tumor type of approach that exploits any metabolic pathways unique to the particular type of tumor. Melanin-producing melanomas actively transport and metabolize aromatic amino acids for use as precursors in the synthesis of the pigment melanin. It has been shown that the boron-containing amino acid analog p-borono-phenylalanine (BPA) is selectively accumulated in melanoma tissue, producing boron concentrations in tumor that are within the range estimated to be necessary for successful boron neutron capture therapy (BNCT). We report here the results of therapy experiments carried out at the Brookhaven Medical Research Reactor (BMRR). 21 refs., 5 figs., 3 tabs

162

Neutron capture therapy for melanoma  

Energy Technology Data Exchange (ETDEWEB)

The development of boron-containing compounds which localize selectively in tumor may require a tumor-by-tumor type of approach that exploits any metabolic pathways unique to the particular type of tumor. Melanin-producing melanomas actively transport and metabolize aromatic amino acids for use as precursors in the synthesis of the pigment melanin. It has been shown that the boron-containing amino acid analog p-borono-phenylalanine (BPA) is selectively accumulated in melanoma tissue, producing boron concentrations in tumor that are within the range estimated to be necessary for successful boron neutron capture therapy (BNCT). We report here the results of therapy experiments carried out at the Brookhaven Medical Research Reactor (BMRR). 21 refs., 5 figs., 3 tabs.

Coderre, J.A.; Glass, J.D.; Micca, P.; Fairchild, R.G.

1988-01-01

163

Perineural extension of facial melanoma  

Energy Technology Data Exchange (ETDEWEB)

A 64-year-old man presented with a pigmented cutaneous lesion on the right side of his face along with right facial numbness. Histological examination revealed malignant melanoma. Magnetic resonance imaging (MRI) revealed perineural extension along the entire course of the maxillary division of the right trigeminal nerve. This is a rare but important manifestation of the spread of head and neck malignancy. (orig.)

Kalina, Peter [Mayo Clinic, Department of Radiology, Rochester, Minnesota (United States); Bevilacqua, Paula

2005-05-01

164

Malignant Melanoma of Gastroesophageal Junction.  

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A rare case of malignant melanoma arising from the gastroesophageal junction is being reported.Since part of the tumor was adherent with hiatus, palliative procedure in form of Mousseau Barbintube insertion was necessitated. Postoperatively patient was subjected to radiotherapy. Malignantmelanoma of gastroesophageal junction is rare accounting for only 0.1% of the lesions of this region.Surgical treatment requires a far greater margin of excision than the usual squamous cell carcinoma.Intraca...

Arvind Kohli, Anita Kohli

2004-01-01

165

Melanoma and satellite blue papule  

Science.gov (United States)

The colors that are seen in dermoscopy depend on the anatomic level of the skin at which the chromophores are seen. Blue color can be found in a variety of melanocytic and nonmelanocytic lesions. An 89-year-old man presented with a 3-year history of a slow-growing, hyperpigmented patch located on the distal third of the right arm. Dermoscopy showed an atypical network, irregularly distributed globules, pigmented internal streaks and a milky-red area. Based on these findings a diagnosis of slow-growing malignant melanoma was made. Simultaneously, a well-defined blue papule was seen on the proximal third of the same arm. Dermoscopy disclosed a homogeneous blue pattern. After clinical and dermoscopic correlation our differential diagnosis for this blue lesion included cutaneous melanoma metastasis, blue nevus and foreign body reaction. The patient recalled its onset 75 years ago after a grenade explosion. We also discuss the blue lesion appearance under reflectance confocal microscopy and high-definition optical coherence tomography. Histopathological examination after excision of the hyperpigmented patch and blue papule revealed a melanoma in situ and a foreign body reaction, respectively. The diagnostic evaluation of a blue lesion should always rely on the integration of all data, especially clinical and dermoscopic features. Other non-invasive techniques, like reflectance confocal microscopy and high-definition optical coherence tomography can also be important aids for its differential diagnosis. PMID:25126462

Oliveira, Andre; Arzberger, Edith; Massone, Cesare; Zalaudek, Iris; Fink-Puches, Regina; Hofmann-Wellenhof, Rainer

2014-01-01

166

Simvastatin impairs murine melanoma growth  

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Full Text Available Abstract Background Statins induces cell cycle arrest, apoptosis, reduction of angiogenic factors, inhibition of the endothelial growth factor, impairing tissue adhesion and attenuation of the resistance mechanisms. The aim of this study was evaluate the anti-tumoral activity of simvastatin in a B16F10 melanoma-mouse model. Methods Melanoma cells were treated with different concentrations of simvastatin and assessed by viability methods. Melanoma cells (5 × 104 were implanted in two month old C57Bl6/J mice. Around 7 days after cells injection, the oral treatments were started with simvastatin (5 mg/kg/day, p.o.. Tumor size, hematological and biochemical analyses were evaluated. Results Simvastatin at a concentration of 0.8 ?M, 1.2 ?M and 1.6 ?M had toxic effect. Concentration of 1.6 ?M induced a massive death in the first 24 h of incubation. Simvastatin at 0.8 ?M induces early cell cycle arrest in G0/G1, followed by increase of hypodiploidy. Tumor size were evaluated and the difference of treated group and control, after ten days, demonstrates that simvastatin inhibited the tumor expansion in 68%. Conclusion Simvastatin at 1.6 ?M, presented cytototoxicity after 72 h of treatment, with an intense death. In vivo, simvastatin being potentially useful as an antiproliferative drug, with an impairment of growth after ten days.

Barros Francisco E

2010-12-01

167

Melanoma and satellite blue papule.  

Science.gov (United States)

The colors that are seen in dermoscopy depend on the anatomic level of the skin at which the chromophores are seen. Blue color can be found in a variety of melanocytic and nonmelanocytic lesions. An 89-year-old man presented with a 3-year history of a slow-growing, hyperpigmented patch located on the distal third of the right arm. Dermoscopy showed an atypical network, irregularly distributed globules, pigmented internal streaks and a milky-red area. Based on these findings a diagnosis of slow-growing malignant melanoma was made. Simultaneously, a well-defined blue papule was seen on the proximal third of the same arm. Dermoscopy disclosed a homogeneous blue pattern. After clinical and dermoscopic correlation our differential diagnosis for this blue lesion included cutaneous melanoma metastasis, blue nevus and foreign body reaction. The patient recalled its onset 75 years ago after a grenade explosion. We also discuss the blue lesion appearance under reflectance confocal microscopy and high-definition optical coherence tomography. Histopathological examination after excision of the hyperpigmented patch and blue papule revealed a melanoma in situ and a foreign body reaction, respectively. The diagnostic evaluation of a blue lesion should always rely on the integration of all data, especially clinical and dermoscopic features. Other non-invasive techniques, like reflectance confocal microscopy and high-definition optical coherence tomography can also be important aids for its differential diagnosis. PMID:25126462

Oliveira, André; Arzberger, Edith; Massone, Cesare; Zalaudek, Iris; Fink-Puches, Regina; Hofmann-Wellenhof, Rainer

2014-07-01

168

Treatment of malignant melanoma by selective thermal neutron capture therapy using melanoma-seeking compound  

International Nuclear Information System (INIS)

As pigment cells undergo melanoma genesis, accentuated melanogenesis concurrently occurs in principle. Subsequent to the understanding of intrinsic factors controlling both processes, we found our selective melanoma neutron capture therapy (NCT) using 10B-dopa (melanin substrate) analogue, 10B1-p-boronophenylalanine (10B1-BPA), followed by 10B(n, alpha)7Li reaction, induced by essentially harmless thermal neutrons, which releases energy of 2.33 MeV to 14 mu, the diameter of melanoma cells. In vitro/in vivo radiobiological analysis revealed the highly enhanced melanoma killing effect of 10B1-BPA. Chemical and prompt gamma ray spectrometry assays of 10B accumulated within melanoma cells after 10B1-BPA administration in vitro and in vivo show high affinity, e.g., 10B melanoma/blood ratio of 11.5. After successfully eradicating melanoma transplanted into hamsters with NCT, we advanced to preclinical studies using spontaneously occurring melanoma in Duroc pig skin. We cured three melanoma cases, 4.6 to 12 cm in diameter, by single neutron capture treatment. Complete disappearance of melanoma was obtained without substantial side effects. Acute and subacute toxicity as well as pharmacodynamics of 10B1-BPA have been studied in relation to therapeutic dosage requirements. Clinical radiation dosimetry using human phantom has been carried out. Further preclinical studies using human melanoma transplanted into nude mouse have been a useful model for obtaining optimal results forul model for obtaining optimal results for each melanoma type. We recently treated the first human melanoma patient with our NCT, using essentially the method for Duroc pig melanoma, and obtained similar regression time course leading to cure

169

Mistletoe in the treatment of malignant melanoma  

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Full Text Available Malignant melanoma is a malignant neoplasia drives from melanocytes. Malignant melanoma, the most causing death, is seen in the third place at skin cancer. Malignant melanoma shows intrinsic resistance to chemotherapeutic agents and variability in the course of the disease which are distinct features separating from other solid tumors. These features prevent the development and standardization of non-surgical treatment models of malignant melanoma. Although there is a large number of chemotherapeutic agents used in the treatment of metastatic malignant melanoma, it hasn’t been demonstrated the survival advantage of adjuvant treatment with chemotherapeutic agents. Because of the different clinical course of malignant melanoma, the disease is thought to be closely associated with immune system. Therefore, immunomodulatory therapy models were developed. Mistletoe stimulates the immune system by increasing the number and activity of dendritic cells, thus it has been shown to effect on tumor growth and metastasis of malignant melanoma patient. Outlined in this review are the recent developments in the understanding the role of mistletoe as a complementary therapy for malignant melanoma. J Clin Exp Invest 2014; 5 (1: 145-152

Esin Sakall? Çetin

2014-03-01

170

Sentinel node in management of malignant melanoma.  

Directory of Open Access Journals (Sweden)

Sentinel lymph node biopsy is increasingly used to stage melanoma in order to avoid lymph node dissection in patients who clinically have no lymph node involvement. Sentinel lymph node biopsy is a valuable technique for melanoma staging; however, impact on overall survival requires longer follow-up.

Asem A. Al-Hiari

2002-12-01

171

Mangement of malignant melanomas: an overview.  

Science.gov (United States)

This paper presents an overview of the management of malignant melanoma. It considers the value of wide reexcision relative to the depth of invasion of the melanoma. It considers the indications for elective lymphadenectomy and presents a critical review of chemotherapy, immunotherapy and other procedures, such as X ray. The conclusion is that surgery, wherever feasible, is still the best approach. PMID:762300

Epstein, W L

1979-02-01

172

Effects of cuminaldehyde on melanoma cells.  

Science.gov (United States)

Cuminaldehyde (4-isopropylbenzaldehyde) suppressed melanin formation in cultured murine B16-F10 melanoma cells in a dose-dependent decrease up to 0.25 mm without affecting cell growth. Approximately 30% suppression in melanin production resulted when the cells were cultured with 0.25 mm of cuminaldehyde. This activity was not noticeable with cultured human A375 melanoma cells. PMID:18412105

Nitoda, Teruhiko; Fan, Maria D; Kubo, Isao

2008-06-01

173

Malignant melanoma at a scientific laboratory  

International Nuclear Information System (INIS)

The general consensus of the seven reviewers is that occupational exposures at Lawrence Livermore National Laboratory have not been established as a causal factor for the observed excess of malignant melanoma. Several observations support the impression that some or all of the observed melanoma excess may be attributable to intense surveillance and enhanced detection of early stage melanoma lesions. Since the incidence of melanomas among Laboratory employees has not diminished, an early harvesting effect is unlikely. This suggests the distinct possibility that localized, in situ melanomas that would normally not be detected are being reported, and that in the absence of this enhanced detection, many of these early stage lesions would show little or no clinical progression. This phenomenon would explain the continued high incidence of melanomas in the absence of a physical or chemical inciting cause. A key point in this reasoning is the issue of the rate of growth of early stage melanomas, and this point remains a key question for study. Even if the observed excess cannot be explained by detection bias, the reviewers agree that the Austin and Reynolds' study does not make a convincing case for occupational factors being a cause of the high melanoma incidence. 6 refs

174

Malignant melanoma with probable smooth muscle differentiation.  

Science.gov (United States)

Malignant melanomas occasionally exhibit various divergent differentiation types. Of these, smooth muscle differentiation is extremely rare; only 1 case has been reported in the literature until recently. We report an extremely rare case of malignant melanoma with smooth muscle differentiation, which appeared as an amelanotic reddish nodule on the left toe. PMID:24575006

Morimoto, Aya; Asai, Jun; Wakabayashi, Yusuke; Komori, Satoshi; Hanada, Keiji; Takenaka, Hideya; Konishi, Eiichi; Katoh, Norito

2014-01-01

175

Melanotan-associated melanoma in situ.  

Science.gov (United States)

Injectable synthetic melanotropic peptides (often called melanotan) to enhance tanning are available over the Internet despite being unlicensed compounds with an unproven safety record. There have been reports of dysplastic naevi and melanoma associated with the use of melanotropic peptides. We report a case of melanotan-associated melanoma in situ. PMID:22724573

Ong, Suyin; Bowling, Jonathan

2012-11-01

176

Epidemiología del melanoma cutáneo / Epidemiology of cutaneous melanoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Durante las últimas décadas hubo un aumento de la incidencia del melanoma cutáneo en la población caucásica del mundo, aunque este tumor puede afectar a cualquier grupo étnico. En la actualidad se considera a la exposición solar intermitente como un factor de riesgo cierto, en el desarrollo del mela [...] noma cutáneo. La incidencia del melanoma cutáneo en Auckland, Nueva Zelanda, es la mayor del mundo. En Europa, la incidencia y la mortalidad fue creciente hasta que en la década de los 80 se estabilizó. En EEUU también se observó una estabilización de la incidencia. Con respecto a la edad, según la bibliografía consultada la incidencia aumenta a partir de los 20 años; en algunos pacientes con más de 200 nevos y sin pautas de protección solar antes de los 5 años de vida. También se observa aumento de la incidencia en los adultos mayores de 60 años de edad. Con respecto al sexo, en los EEUU y la Argentina es más frecuente en los hombres y en Europa en el sexo femenino. Abstract in english During the last decades there was an increase of incidence of cutaneous melanoma in Caucasian population worldwide, but this tumor can affect any ethnic group. Nowadays, the intermittent solar exposition is a well known predisposing factor. The incidence in Auckland, New Zealand, is the highest in t [...] he world. In Europe and in the USA, the incidence and mortality rates decreased until the 80's when it stabilized. Regarding the age of appearance, the incidence increases starting at 20 years of age in patients with more than 200 nevi and without history of sun protection in childhood. There was also an increase in the incidence in adults (>60 y-o). The distribution by sex in USA and Argentina is more frequent in males and in Europe in females.

R M C, Leitner.

177

Alpha particles for treatment of disseminated melanoma  

International Nuclear Information System (INIS)

Invading melanoma spreads to local and unpredictable distant location at the early stages of its development. It is justifiable, therefore, to classify the disease as a systemic disorder. This requires a systemic treatment that reaches all melanoma cells irrespective of whether they are singly dispersed and in circulation or already forming solid tumours of various sizes. Targeted radiotherapy affects directly and selectively cancer cells provided an appropriate radionuclide and its carrier are chosen. Melanoma is a pigmented tumour. Methylene blue (MTB)) accumulates selectively in melanoma cells due to its exceptionally high affinity to melanin. MTB serves, therefore, as a carrier for radionuclides. 211At-MTB has proved to be particularly effective in treating disseminated melanoma when administered systemically and, at the same time, non-toxic to normal non-pigmented and pigmented organs. (authors)

178

Choroidal melanoma metastasizing to maxillofacial bones  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Melanomas are malignant neoplasm of melanocytic origin, commonly seen on skin and various mucous membranes. Melanomas are the commonest intraocular malignant tumour in the adults. Case presentation A 50-year-old female presented with complains of painless progressive swelling in right cheek region of two months duration. Examination revealed a 6 × 4 cm bony hard swelling in right zygomatic region near and below lateral canthus of right eye with loss of vision. Investigations revealed it to be a choroidal melanoma metastatising to the zygomatic bone. Patient was successfully treated by surgery. Conclusion Choroidal melanoma, which commonly metastasizes to liver and lungs, never involves the lymph nodes and metastasis to facial bones is rare. Here we report a case of choroidal melanoma metastasizing to maxillofacial bones.

Mathews Anitha

2007-03-01

179

Alpha particles for treatment of disseminated melanoma  

Energy Technology Data Exchange (ETDEWEB)

Invading melanoma spreads to local and unpredictable distant location at the early stages of its development. It is justifiable, therefore, to classify the disease as a systemic disorder. This requires a systemic treatment that reaches all melanoma cells irrespective of whether they are singly dispersed and in circulation or already forming solid tumours of various sizes. Targeted radiotherapy affects directly and selectively cancer cells provided an appropriate radionuclide and its carrier are chosen. Melanoma is a pigmented tumour. Methylene blue (MTB)) accumulates selectively in melanoma cells due to its exceptionally high affinity to melanin. MTB serves, therefore, as a carrier for radionuclides. {sup 211}At-MTB has proved to be particularly effective in treating disseminated melanoma when administered systemically and, at the same time, non-toxic to normal non-pigmented and pigmented organs. (authors)

Link, E.M. [London University (United Kingdom)

2010-07-01

180

Alpha particles for treatment of disseminated melanoma  

Energy Technology Data Exchange (ETDEWEB)

Invading melanoma spreads to local and unpredictable distant location at the early stages of its development. It is justifiable, therefore to classify the disease as a systemic disorder. This requires a systemic treatment that reaches all melanoma cells irrespective of whether they are singly dispersed and in circulation or already forming solid tumours of various sizes. Targeted radiotherapy affects directly and selectively cancer cells provided an appropriate radionuclide and its carrier are chosen. Melanoma is a pigmented tumour. Methylene blue (MTB) accumulates selectively in melanoma cells due to its exceptionally high affinity to melanin. MTB serves, therefore, as a carrier for radionuclides. {sup 211}At-MTB has proved to be particularly effective in treating disseminated melanoma when administered systemically and, at the same time, non-toxic to normal non-pigmented and pigmented organs. (author)

Link, E.M. [London Univ. (United Kingdom)

2010-11-15

 
 
 
 
181

Melanoma Surveillance in the US: Collecting Melanoma Data  

Centers for Disease Control (CDC) Podcasts

This podcast accompanies the publication of a series of articles on melanoma surveillance in the United States, available in the November supplement edition of the Journal of the American Academy of Dermatology. Dr. Suephy Chen, a dermatologist from Emory University, discusses why the articles are important, as well as the need to increase dermatologistsâ?? awareness of cancer registries and reporting requirements.  Created: 10/19/2011 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/19/2011.

2011-10-19

182

The association between Parkinson's disease and melanoma.  

Science.gov (United States)

Parkinson's disease (PD) is a neurodegenerative disorder characterized by a loss of melanin-positive, dopaminergic neurons in the substantia nigra. Although there is convincing epidemiologic evidence of a negative association between PD and most cancers, a notable exception to this is that melanoma, a malignant tumor of melanin-producing cells in skin, occurs with higher-than-expected frequency among subjects with PD and that melanoma patients are more likely to have PD. A clear biological explanation for this epidemiological observation is lacking. Here, we present a comprehensive review of published literature exploring the association between PD and melanoma. On the basis of published findings, we conclude that (i) changes in pigmentation including melanin synthesis and/or melanin synthesis enzymes, such as tyrosinase and tyrosine hydroxylase, play important roles in altered vulnerability for both PD and melanoma; (ii) changes of PD-related genes such as Parkin, LRRK2 and ?-synuclein may increase the risk of melanoma; (iii) changes in some low-penetrance genes such as cytochrome p450 debrisoquine hydroxylase locus, glutathione S-transferase M1 and vitamin D receptor could increase the risk for both PD and melanoma and (iv) impaired autophagy in both PD and melanoma could also explain the association between PD and melanoma. Future studies are required to address whether altered pigmentation, PD- or melanoma-related gene changes and/or changes in autophagy function induce oncogenesis or apoptosis. From a clinical point of view, early diagnosis of melanoma in PD patients is critical and can be enhanced by periodic dermatological surveillance, including skin biopsies. PMID:21207412

Pan, Tianhong; Li, Xinqun; Jankovic, Joseph

2011-05-15

183

SOX10 promotes melanoma cell invasion by regulating melanoma inhibitory activity.  

Science.gov (United States)

The transcription factor SOX10 (SRY (sex determining region Y)-box 10) has a key role in the embryonic development of melanocytes. Recently, it has been suggested that SOX10 is highly relevant for melanoma development and survival. However, the distinct functions and downstream targets of SOX10 in melanoma remain widely unknown. In this study, we inhibited SOX10 via RNA interference in different human melanoma cell lines and found a significantly reduced invasion capacity in vitro and in the chick embryo model. At later time points, SOX10 inhibition reduced proliferation and induced cell death. We identified melanoma inhibitory activity (MIA) as a direct target gene of SOX10, which is an essential protein for melanoma cell migration and invasion. Expression levels of SOX10 and MIA strictly correlated in melanoma cell lines, and SOX10 inhibition reduced MIA expression and promoter activity. Direct binding of SOX10 to the MIA promoter was demonstrated by electrophoretic mobility shift assay and chromatin immunoprecipitation. Ectopic expression of MIA in SOX10-inhibited melanoma cells restored the invasion capacity, supporting the hypothesis that MIA is responsible for SOX10-mediated melanoma cell invasion. Our data provide evidence for a critical role of SOX10 in melanoma cell invasion through the regulation of MIA and highlight its role as a therapeutic target in melanoma. PMID:24608986

Graf, Saskia A; Busch, Christian; Bosserhoff, Anja-Katrin; Besch, Robert; Berking, Carola

2014-08-01

184

Melanoma susceptibility genes and risk assessment.  

Science.gov (United States)

Familial melanoma accounts for approximately a tenth of all melanoma cases. The most commonly known melanoma susceptibility gene is the highly penetrant CDKN2A (p16INK4a) locus, which is transmitted in an autosomal dominant fashion and accounts for approximately 20-50 % of familial melanoma cases. Mutated p16INK4a shows impaired capacity to inhibit the cyclin D1-CDK4 complex, allowing for unchecked cell cycle progression. Mutations in the second protein coded by CDKN2A, p14ARF, are much less common and result in proteasomal degradation of p53 with subsequent accumulation of DNA damage as the cell progresses through the cell cycle without a functional p53-mediated DNA damage response. Mutations in CDK4 that impair the inhibitory interaction with p16INK4a also increase melanoma risk but these mutations are extremely rare. Genes of the melanin biosynthetic pathway, including MC1R and MITF, have also been implicated in melanomagenesis. MC1R variants were traditionally thought to increase risk for melanoma secondary to intensified UV-mediated DNA damage in the setting of absent photoprotective eumelanin. Accumulation of pheomelanin, which appears to have a carcinogenic effect regardless of UV exposure, may be a more likely mechanism. Impaired SUMOylation of the E318K variant of MITF results in increased transcription of genes that confer melanocytes with a pro-malignant phenotype. Mutations in the tumor suppressor BAP1 enhance the metastatic potential of uveal melanoma and predispose to cutaneous/ocular melanoma, atypical melanocytic tumors, and other internal malignancies (COMMON syndrome). Genome-wide association studies have identified numerous low-risk alleles. Although several melanoma susceptibility genes have been identified, risk assessment tools have been developed only for the most common gene implicated with hereditary melanoma, CDKN2A. MelaPRO, a validated model that relies on Mendelian inheritance and Bayesian probability theories, estimates carrier probability for CDKN2A and future risk of melanoma taking into account a patient's family and past medical history of melanoma. Genetic testing for CDKN2A mutations is currently available but the Melanoma Genetics Consortium recommends offering such testing to patients only in the context of research protocols because clinical utility is uncertain. PMID:24258989

Marzuka-Alcalá, Alexander; Gabree, Michele Jacobs; Tsao, Hensin

2014-01-01

185

Targeted drug for uveal melanoma  

Science.gov (United States)

Researchers from Memorial Sloan-Kettering Cancer Center presented findings at the annual meeting of the American Society for Clinical Oncology from a study testing the experimental drug selumetinib as a treatment for patients with metastatic uveal melanoma. This treatment more than doubled the time to progression when compared with chemotherapy. Many patients receiving selumetinib experienced tumor shrinkage, making selumetinib the first systemic therapy ever to benefit patients with this cancer. The findings are potentially practice changing for a disease that has previously had no known effective therapy.

186

The risk of cutaneous melanoma in melanocytic nevi Risco de melanoma cutâneo nos nevos melanocíticos  

Directory of Open Access Journals (Sweden)

Full Text Available The data on melanoma associaed with melanocytic nevus are controversial. A longitudinal prospective study of 107 cases of cutaneous melanoma revealed that 9 (8.4% cases were presumed to be linked to a precursor lesion, but only in 1 (0.9% out of these cases the histopathological examination showed an associated melanocytic nevus. The vague information of a preexisting lesion of cutaneous melanoma is not sufficient to consider it a tumour precursor and it requires histopathological evidence to confirm the diagnosis.Os dados sobre risco de melanoma cutâneo nos nevos melanocíticos são ainda controversos. O estudo longitudinal prospectivo de 107 casos de melanoma cutâneo revelou que em 9/107 casos (8,4% houve presunção de lesão precursora, porém em 1/107 caso (0,9% houve comprovação histopatológica para nevo melanocítico. A informação vaga de presença de lesão precursora do melanoma cutâneo torna vulnerável sua vinculação com o tumor e implica em comprovação histopatológica.

Nurimar Conceição Fernandes

2013-04-01

187

Ellagic acid inhibits melanoma growth in vitro  

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Full Text Available Ellagic is a polyphenolic compound with anti-fibrotic and antioxidant properties as well as exhibits antitumor properties against various cancer cells in vitro. There are few studies, however, which examine the effects of ellagic acid on melanoma. In the present study, we observe effects of ellagic acid on melanoma cells in vitro. Three metastatic melanoma cell lines (1205Lu, WM852c and A375 were examined to determine the effects of ellagic acid on melanoma cell viability, cell-cycle, apoptosis, NF-?? activity, and IL-1? & IL-8 secretion. Cell viability assays demonstrated that ellagic acid possesses an inhibitory effect on cell proliferation at concentrations between 25 and 100 µM. In addition, ellagic acid promoted G1 cell cycle arrest, increased levels of apoptosis and decreased synthesis of IL-1? and IL-8 in melanoma cells. Ellagic acid also decreased NF-?? activity, suggesting at least one potential mechanism by which ellagic acid may exert its effects in melanoma cells. Our findings support further investigation into prospective roles for ellagic acid as a therapeutic, adjuvant, or preventive agent for melanoma.

Robert P. Dellavalle

2011-10-01

188

Malignant blue nevus: clinicopathologically similar to melanoma.  

Science.gov (United States)

Malignant blue nevus (MBN) is a rare melanocytic lesion and controversy exists whether it is a melanoma or a unique entity. We sought to establish clinical behavior using a large national registry. All patients with MBN and melanoma from 1973 to 2008 were identified in the Surveillance Epidemiology and End Results tumor registry. We performed comparative and survival analysis among the two tumor types. A total of 228,038 patients were identified (227,986 with melanoma and 52 with MBN). The mean age was 57.7 years. Both lesions had similar age of presentation (55.8 vs 55.7 years, P = 0.527), sex (male 50 vs 55%, P = 0.44), and nodal positivity rate (9.6 vs 5.4%, P = 0.22). MBNs were more likely to be nonwhite (11.8 vs 1.6%, P < 0.0001) and present with metastatic disease (15.2 vs 4%, P = 0.0028). MBN and melanoma had a similar survival (264 vs 240 months, P = 0.78) and remained similar when stratified by race (264 vs 242 months, P = 0.99) and stage (264 vs 256 months, P = 0.83). This is the largest study to date demonstrating similar clinical behavior and survival between patients with MBN and those with melanoma. We believe MBN is a variant of melanoma and suggest using a similar treatment algorithm as that of melanoma. PMID:23815995

Kachare, Swapnil Dilip; Agle, Steven C; Englert, Zachary P; Zervos, Emmanuel E; Vohra, Nasreen A; Wong, Jan H; Fitzgerald, Timothy L

2013-07-01

189

Molecular targeted therapies in metastatic melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Rima Chakraborty,1 Carilyn N Wieland,2 Nneka I Comfere2 1University of Missouri-Kansas City Medical School, Kansas City, MO, 2Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA Abstract: The advent of personalized medicine has ushered in a new era for cancer therapy with a significant impact on the management of advanced melanoma. Molecular targeted therapies have shown promise in the management of various malignancies, including melanoma, with lower toxicity profiles and better overall survival as compared with conventional therapy. The discovery of BRAF mutations in melanoma led to the development of BRAF inhibitors for the treatment of advanced melanoma. However, growing concerns over drug resistance to molecular targeted therapies including BRAF inhibitors, have spurred efforts to elucidate additional molecular targets for the treatment of advanced melanoma. In this review, we discuss the known molecular aberrations in melanoma, current and novel targeted approaches in its treatment, and drug resistance patterns. Keywords: BRAF inhibitors, metastatic melanoma, personalized medicine

Chakraborty R

2013-06-01

190

[Melanomas more serious in the elderly].  

Science.gov (United States)

Two patients, a 96-year-old woman and a 94-year-old man, were diagnosed with metastatic cutaneous melanoma. The first patient had undergone radical excision of the primary tumour 18 months before. The second patient presented with neurological symptoms caused by a metastatic melanoma; the primary tumour had recently been resected. Both patients died within three weeks of the diagnosis. Cutaneous melanomas have a high metastatic rate. Treatment options are limited for metastatic disease. The incidence of melanoma increases with age. Old age is an independent risk factor, which is also associated with a poor prognosis. Older patients more often present with more serious histological characteristics and more aggressive types of melanoma. The Breslow thickness is also higher in patients aged 65 or over. Nodular melanoma, lentigo maligna or acral lentiginous melanoma are observed more frequently in this group of patients. Moreover, elderly people more frequently present with liver or cerebral metastases. Early diagnosis improves the prognosis, also in the elderly. PMID:20482904

van der Meijden, Wilbert A G; van Bruchem-Visser, Rozemarijn L; Thio, H Bing; van der Cammen, Tischa J M

2010-01-01

191

IRF5 gene polymorphisms in melanoma  

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Full Text Available Abstract Background Interferon regulatory factor (IRF-5 is a transcription factor involved in type I interferon signaling whose germ line variants have been associated with autoimmune pathogenesis. Since relationships have been observed between development of autoimmunity and responsiveness of melanoma to several types of immunotherapy, we tested whether polymorphisms of IRF5 are associated with responsiveness of melanoma to adoptive therapy with tumor infiltrating lymphocytes (TILs. Methods 140 TILs were genotyped for four single nucleotide polymorphisms (rs10954213, rs11770589, rs6953165, rs2004640 and one insertion-deletion in the IRF5 gene by sequencing. Gene-expression profile of the TILs, 112 parental melanoma metastases (MM and 9 cell lines derived from some metastases were assessed by Affymetrix Human Gene ST 1.0 array. Results Lack of A allele in rs10954213 (G?>?A was associated with non-response (p?in vitro between cell lines carrying or not the A allele could be applied to the transcriptional profile of 112 melanoma metastases to predict their responsiveness to therapy, suggesting that IRF5 genotype may influence immune responsiveness by affecting the intrinsic biology of melanoma. Conclusions This study is the first to analyze associations between melanoma immune responsiveness and IRF5 polymorphism. The results support a common genetic basis which may underline the development of autoimmunity and melanoma immune responsiveness.

Uccellini Lorenzo

2012-08-01

192

Brain metastases from malignant melanoma  

International Nuclear Information System (INIS)

Between 1985 and 1993 30 patients underwent radiation therapy for brain metastases from malignant melanoma. In 9 patients they had been surgically resected. All except 1 patient received whole brain irradiation with a total dose of 20 to 46 Gy/2 to 5 weeks using daily fractions of 2,0 to 4,0 Gy. In 5 patients a local boost of 20 to 25 Gy/2 weeks was administered. Survival rates were compared using the Cox-method. Univariate and multivariate analyses were performed to define prognostic subgroups. In 6/30 patients (20%) brain metastases were diagnosed at the time of primary manifestation of melanoma. In 83% of patients brain metastases developed during the first 5 years following primary diagnosis. Late manifestation was observed (18 years). Overall survival rate of the whole group was 39% at 6 months and 23% at 1 year. Univariate analysis revealed that age at diagnosis of brain metastases, time to manifestation, number of intracranial metastases and existence of extracerebral distant metastases had significant influence on survival. Sex was not found to influence survival rate. Multivariate analysis identified the existence of extracerebral distant metastases at the time of diagnosis of brain metastases as the most important prognostic factor for survival, followed by age and surgical resection. The role of fractionation was studied separately in a subgroup of patients receiving whole brain irradiation to a total dose of 39 to 42 Gy. Survival rates deteriorated when overall treatment time exceeded 3 weeks. (orig./MG)

193

Myeloid cells' evasion of melanoma immunity.  

Science.gov (United States)

An immune-suppressive role of myeloid-derived suppressor cells (MDSCs) in melanoma has long been speculated, whereas molecular mechanisms underlying this role are not well understood. Here, Chung and colleagues show that dendritic cell-associated, heparan sulfate proteoglycans-dependent integrin ligand (DC-HIL), a cell surface immune-modulatory molecule, is highly expressed on tumor-associated MDSCs. Genetic ablation or antibody blockade of DC-HIL delays the growth of transplantable B16 melanoma in syngeneic mice, which is accompanied by enhanced antitumor T-cell activities. These findings support a role for DC-HIL in immune evasion within the melanoma microenvironment. PMID:25318429

Wang, Jun; Chen, Lieping

2014-11-01

194

A potential new radiopharmaceutical for melanoma imaging  

International Nuclear Information System (INIS)

In the sequence of our studies on radiopharmaceuticals for malignant melanoma detection the results were most promising for the possible use of 125I or 123I - N-(2-diethyl amino ethyl) 4-iodobenzamide. The biodistribution in mice bearing melanoma either human or animal from 4 to 24 hrs. post i.v. injection showed high uptake in tumor tissue together with relatively low uptake in muscle, brain, lung and liver. Scintigraphic images of the tumor obtained at the same times confirmed that melanoma detection was very promising

195

Tea tree oil might combat melanoma.  

Science.gov (United States)

In this study we present new data from experiments focused on the antitumor activity of tea tree oil (TTO), an essential oil distilled from Melaleuca alternifolia. TTO proved to be capable of inhibiting the growth of melanoma cells and of overcoming multidrug resistance (MDR), as we reported in our previous study. Moreover, the survival role of the MDR-marker P-glycoprotein appears to be involved in the mechanism of invasion of melanoma cells. The results reported herein indicate that TTO and its main active component, terpinen-4-ol, can also interfere with the migration and invasion processes of drug-sensitive and drug-resistant melanoma cells. PMID:20560116

Bozzuto, Giuseppina; Colone, Marisa; Toccacieli, Laura; Stringaro, Annarita; Molinari, Agnese

2011-01-01

196

Dermoscopic patterns of cutaneous melanoma metastases.  

Science.gov (United States)

In 2-8% of patients with melanoma, the first clinical manifestation of the disease may be skin metastasis. In these cases, differential diagnosis with the primary melanoma, benign melanocytic lesions, and other malignant and benign skin growths is particularly challenging. For this reason, the dermatologist's approach to cutaneous metastases of malignant melanoma calls for knowledge of the great morphological variety of these lesions. Dermoscopic characteristics associated with CMMMs have not yet been codified. The aim of the present review is to provide additional information about dermoscopic aspects of these skin lesions. PMID:24320196

Rubegni, Pietro; Lamberti, Arianna; Mandato, Filomena; Perotti, Roberto; Fimiani, Michele

2014-04-01

197

Malignant Melanoma Presenting as Superior Mediastinal Mass without Extrathoracic Primary Melanoma  

International Nuclear Information System (INIS)

Malignant melanoma most commonly occurs in the skin, and other organs are secondarily involved. Malignant melanoma presenting in the mediastinum without an extrathoracic primary is very rare. Authors report a case of malignant melanoma of the superior mediastinum without clinical history of extrathoracic malignant melanoma primarily and discuss its radiologic findings. CT shows lobulated heterogenous enhanced mass. Magnetic resonance shows mild hyperintense mass on T1 and T2-weighted images contained focal hemorrhage and necrosis, and invasion to neural foramen. In addition, positron emission tomography/computed tomography shows high standard uptake values uptake of the mass.

198

Experimental boron neutron capture therapy for melanoma: Systemic delivery of boron to melanotic and amelanotic melanoma  

Energy Technology Data Exchange (ETDEWEB)

The boron-containing melanin precursor analogue p-boronophenylalanine (BPA) has previously been shown to selectively deliver boron to pigmented murine melanomas when administered in a single intragastric dose. If boron neutron capture therapy is to become a clinically useful method of radiation therapy for human malignant melanoma, the boron carrier must be capable of delivering useful amounts of boron to remote tumor sites (metastases) and to poorly pigmented melanomas. The authors have now determined the ability of BPA to accumulate in several nonpigmented melanoma models including human melanoma xenografts in nude mice. The absolute amount of boron in the nonpigmented melanomas was about 50% of the observed in the pigmented counterparts but was still selectively concentrated in the tumor relative to normal tissues in amounts sufficient for effective neutron capture therapy. Single intragastric doses of BPA resulted in selective localization of boron in the amelanotic Greene melanoma carried in the anterior chamber of the rabbit eye and in a pigmented murine melanoma growing in the lungs. The ratio of the boron concentration in these tumors to the boron concentration in the immediately adjacent normal tissue was in the range of 3:1 to 4:1. These distribution studies support the proposal that boron neutron capture therapy may be useful as a regional therapy for malignant melanoma.

Coderre, J.A.; Glass, J.D.; Micca, P.; Greenberg, D. (Brookhaven National Lab., Upton, NY (United States)); Packer, S. (Brookhaven National Lab., Upton, NY (United States) North Shore University Hospital Manhasset, NY (United States))

1990-01-01

199

Expression of melanoma inhibitory activity in melanoma and nonmelanoma tissue specimens.  

Science.gov (United States)

Melanoma inhibitory activity (MIA) is a small soluble protein secreted by malignant melanoma cells and chondrocytes. Prior studies suggested that MIA expression was relatively tissue-specific, making it a potentially useful marker for melanoma. The current investigations sought to more clearly define the range of tumor/tissue-types where MIA is expressed, compared with expression of 4 other potential melanoma marker genes (tyrosinase melanoma antigen recognized by T cells [MART-1/MelanA], gp100, and melanoma growth-stimulatory activity [MGSA/Gro alpha]). Expression of these genes was assayed by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry in 23 melanoma tumor specimens and in 25 additional nonmelanoma or nonmalignant specimens. MIA, tyrosinase, and MGSA were expressed in most melanoma specimens. Specificity was highest for MART-1, followed by MIA and tyrosinase. Increasing the number of cycles of amplification from 35 to 40 increased sensitivity but decreased specificity of most markers, though MIA was relatively robust. MIA mRNA was also detected in carcinomas of the colon, ovary, kidney, and head/neck, as well as in normal laryngeal epithelium. Although MIA discriminated melanoma from nonmelanoma at least as well as tyrosinase, no single mRNA marker had accuracy greater than 71%, raising potential concern about application of these particular mRNA markers to the minimal disease setting. HUM PATHOL 31:1381-1388. PMID:11112213

Perez, R P; Zhang, P; Bosserhoff, A K; Buettner, R; Abu-Hadid, M

2000-11-01

200

Synthetic Peptide Vaccine for Melanoma Holds Promise  

Science.gov (United States)

Early clinical trials of a synthetic vaccine are showing promise in obtaining an immune response from patients with melanoma, an often-deadly form of skin cancer, according to researchers at the National Cancer Institute (NCI).

 
 
 
 
201

Cell-Based Immunotherapy for Metastatic Melanoma  

Science.gov (United States)

In this phase II trial, researchers are investigating a cell-based form of immunotherapy for stage IV melanoma that produced tumor shrinkage or disappearance in more than 50 percent of patients enrolled in an earlier part of the study.

202

Mucosal malignant melanoma of the maxillary sinus.  

Science.gov (United States)

Mucosal malignant melanoma (MMM) is an aggressive tumour occurring in the upper respiratory tract. It is rare compared to malignant melanoma of the skin. We report a case of a 53-year-old man with left paranasal swelling. A biopsy showed high-grade spindle cell tumour. Subsequently a subtotal maxillectomy was performed. Histopathological examination revealed a hypercellular tumour composed of mixed spindle and epitheloid cells with very occasional intracytoplasmic melanin pigment. The malignant cells were immunopositive for vimentin, S-100 protein and HMB-45. It was diagnosed as mucosal malignant melanoma (MMM). This article illustrates a rare case of MMM where the diagnosis may be missed or delayed without proper histopathological examination that include meticulous search for melanin pigment and appropriate immunohistochemical stains to confirm the diagnosis. Malignant melanoma can mimic many other types of high-grade malignancy and should be considered as a differential diagnosis in many of these instances. PMID:21939172

Norhafizah, M; Mustafa, W M B W; Sabariah, A R; Shiran, M S; Pathmanathan, R

2010-09-01

203

Cutaneous Melanoma: Taiwan Experience and Literature Review  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant melanoma is a rare disease in Taiwan with anincidence rate of 0.65/100,000. Excessive exposure to ultravioletradiation is not associated with most Taiwanese melanomacases. Acral lentiginous melanoma comprises 58% of cutaneousmelanoma. Advanced disease is seen in 50% of cases.Surgery, including resection of the primary melanoma, sentinellymph nodes that may harbor microscopic metastasis, clinicallyabnormal lymph nodes, and selected distant metastases, isthe most important treatment. Lymphatic mapping and sentinellymph node biopsy has changed the clinical stage in 22.2% ofour patients. Adjuvant high-dose interferon significantly prolongsprogression-free survival. However, its use in Taiwan islimited by its substantial toxicity. The prognosis of metastaticdisease remains poor with a median survival of 12 months. Inthe past, chemotherapy alone was the most common treatmentmodality for metastatic disease. Recently biochemotherapy hasbeen more commonly utilized to treat patients with metastatic melanoma.

John Wen-Cheng Chang

2010-12-01

204

Direct bony invasion of malignant melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant melanoma is known to spread by local extention, by the lymphatics by the blood stream. Direct invasion of the bone from a cutaneous melanoma is unknown. Hence, this case is presented in view of its rarity. A 75-year-old Caucasian lady presented with a small papillary lesion in the region of a recurrent chronic cellulitis on the lower third of the lateral aspect of the right leg. Histopathology diagnosed the lesion as locally advanced malignant melanoma. Radiological investigations by X-ray and magnetic resonance imaging revealed malignant infiltration of the tibia in its mid and lower third with two soft tissue metastatic masses adjacent. Histology following amputation confirmed malignant melanoma with cranial resection margin involvement. She underwent a further above-knee amputation followed by chemotherapy. The patient recovered from the amputation but subsequently died 6 months later due to bronchopneumonia from lung metastasis.

Mula Viswanath

2009-01-01

205

Clinical radiobiology of malignant melanoma  

DEFF Research Database (Denmark)

Tumor-control probability (TCP) was analyzed in a series of 121 patients having 239 histologically proven recurrent or metastatic malignant melanomas. These were treated with fractionated radiotherapy with various doses per fraction, total doses, and overall times. Cutaneous lesions (127, 53%) were treated with electron beams, and more deeply seated tumors (112, 47%) with 60Co or 4-8 MV X-rays. The fraction size was highly variable, and this permitted determination of the alpha/beta ratio in the multifraction linear-quadratic model, which was estimated at 0.57 Gy with 95% confidence limits [-1.07, 2.5] Gy. Treatment time had no demonstrable influence on TCP. Thus this tumor exhibits the fractionation sensitivity characteristic of a late-responding normal tissue, suggesting that an adequate fractionation schedule for malignant melanomas would be characterized by larger-than-conventional doses per fraction, possibly about 6 Gy per fraction. This is consistent with the conclusions of other authors. Tumor size, evaluated as mean tumor diameter, S, had a major impact on TCP: the number of target cells increased as a power function of S with exponent 0.72 (95% confidence limits [0.49, 0.94]. In fact, a considerable amount of the heterogeneity in the dose-response data could be removed by accounting for size. Thus, the weak or absent dose response became highly significant. When a patient had multiple lesions, the responses of these to radiotherapy tended to be similar, thus implying that results were significantly influenced by a "hidden parameter" (such as inherent radiosensitivity or immunological status). A test of the predictive value of the TCP-model was performed in a different series of 183 cutaneous and lymph node malignant melanomas. The observed dose-response relationship in this data set was in good agreement with the model prediction. A chi-square test for goodness-of-fit showed that the variation between predicted and observed results could be explained by the binomial variation on quantal response data.

Bentzen, SØren M; Overgaard, Jens

1989-01-01

206

Novel anti-melanoma treatment: focus on immunotherapy  

Directory of Open Access Journals (Sweden)

Full Text Available Melanoma is an intractable cancer that is aggressive, lethal, and metastatic. The prognosis of advanced melanoma is very poor because it is insensitive to chemotherapy and radiotherapy. The incidence of melanoma has been ascending stably for years worldwide, accompanied by increasing mortality. New approaches to managing this deadly disease are much anticipated to enhance the cure rate and to extend clinical benefits to patients with metastatic melanoma. Due to its high degree of immunogenicity, melanoma could be a good target for immunotherapy, which has been developed for decades and has achieved certain progress. This article provides an overview of immunotherapy for melanoma.

Meng-Ze Hao

2014-09-01

207

Spitzoid Melanoma: A Ten Year-Old Boy  

Directory of Open Access Journals (Sweden)

Full Text Available Spitzoid melanoma is a rare variant of melanoma, in which the clinical and histopathologic diagnoses are difficult. Data on the features of Spitzoid melanoma in children is limited in the literature, since melanoma is rarely seen in childhood. Here, we report a 10 year-old child with a Spitzoid melanoma. By the means of this case, it has been emphasized that melanoma should be considered in the differential diagnosis of vascular lesions even seen in childhood, unless the clinical and dermoscopic features are characteristic for an entity. (Journal of Current Pediatrics 2008; 6: 127-9

I??l K?l?nç Karaarslan

2008-01-01

208

Malignant melanoma of the bladder: A case report.  

Science.gov (United States)

Primary malignant melanoma of the bladder is very rare. Rather than being a primary lesion, malignant melanomas of the bladder are more commonly metastatic lesions. The histopathological appearance largely does not differ from that of melanoma at other body sites. It is often difficult to discriminate whether a bladder melanoma is primary or metastatic. Therefore, a careful review of histological features and performing necessary immunohistochemical staining procedures for S-100 protein and HMB-45 are very important in achieving a correct diagnosis. We report a case of hypomelanotic malignant melanoma of the bladder. Despite the variety of therapies available for primary melanomas of the bladder, the prognosis is still poor. PMID:24454603

Sayar, Hamide; Erdogan, Seyda; Adamhasan, Fulya; Gurbuz, Esma; Inci, Mehmet Fatih

2014-01-01

209

The Epidemiology, Prevention, and Detection of Melanoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We are seeing a record number of newly diagnosed skin cancers worldwide, with the incidence of melanoma increasing at a faster rate than almost all other cancers. As clinicians, we will have, by far, the greatest impact on reducing this incidence through better methods of early detection of melanoma and proven prevention methods and techniques. The medical community must enhance its efforts to increase its training of new health care personnel who are capable of diagnosing and treating this r...

Riker, Adam I.; Zea, Nicolas; Trinh, Tan

2010-01-01

210

A LESION MIMICKING MELANOMA OF CHOROID  

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Radiological evaluations were performed as fundus examination was unavailable due to intravitreal hemorrhage in a case who came to our clinic with the complaint of an acute vision loss. Ultrasonography, doppler ultrasonography and magnetic resonance imaging reported that the retinal lesion was compatible with malignant melanoma. The patient underwent diagnostic vitrectomy due to rarity of vitreous hemorrhage with choroidal melanomas. Retinal examination revealed disciform lesion during vitrec...

Özlem Yenice; Haluk Kazoko?lu

2007-01-01

211

A LESION MIMICKING MELANOMA OF CHOROID  

Directory of Open Access Journals (Sweden)

Full Text Available Radiological evaluations were performed as fundus examination was unavailable due to intravitreal hemorrhage in a case who came to our clinic with the complaint of an acute vision loss. Ultrasonography, doppler ultrasonography and magnetic resonance imaging reported that the retinal lesion was compatible with malignant melanoma. The patient underwent diagnostic vitrectomy due to rarity of vitreous hemorrhage with choroidal melanomas. Retinal examination revealed disciform lesion during vitrectomy.

Özlem Yenice

2007-01-01

212

Primary Malignant Melanoma of the Tongue  

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Full Text Available The oral cavity is a rare location for the development of primary malignant melanoma.The most common primary lesion sites are the palate and gingiva. Melanoma of the tongueis specifically uncommon. A 66-year-old woman was referred to our clinic with a complaintof a huge, painless, black, discolored mass on the right side of the oral tongue for 7 years.There were no cutaneous lesions suggestive of malignant melanoma over the rest of herbody. The biopsy of the tongue lesion revealed a histopathology consistent with primarymalignant melanoma. Computed tomography of the neck showed no significant cervicallymphadenopathy. Chest radiograph, whole body bone scanning, and abdominal sonographyrevealed no definite distal metastatic lesions. She received composite resection of thetumor on the right side of the tongue and right functional neck dissection. The patient hadan uneventful recovery and received regular follow-up examinations. She was free of diseasefor more than 2 years. The treatment principle for primary tongue melanoma is widesurgical excision. Early diagnosis will be promoted by careful oral examination and earlybiopsy of pigmented and non-pigmented masses. We reviewed the published reports in theEnglish literature since 1970 and fewer than 30 cases of primary tongue melanoma werepresented. We present a case report and a review of the relevant literature.

Tien-Tse Chiu

2002-11-01

213

[Malignant melanoma of the auditory tube].  

Science.gov (United States)

Melanomas of the mucous membranes of airway tract constitute around 1% of the total melanomas of head and neck. The most common site of the tumor are the nasal and paranasal sinuses but melanomas of the oral cavity are described too. The location of malignant melanoma in the eustachian tube is very rare. We found five cases of this disease in the literature. In our article we present a 53-year-old woman with progressive left aural fullness and hearing impairment for two months. Clinical examination found left middle ear effusion. The nasopharyngoscopy revealed a bluish red, friable and granulomatous tumor occupying the whole pharyngeal orifice of the left auditory tube. The biopsy speciment was taken which established the diagnosis. Because of localization and spread of the melanoma we had a low opinion of surgical treatment and radiotherapy was recommended. The patient was under constant laryngologic and oncological observation. We did not notice the local recurrence of melanoma. She died two years after making the diagnosis because of the neoplasm dissemination. PMID:17847794

Tywo?czuk-Szulc, Monika; Kibi?da, Bogdan

2007-01-01

214

Melanoma and rituximab: an incidental association?  

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Rituximab is an anti-CD20 monoclonal antibody increasingly used in haematology and rheumatology, but also in internal medicine and dermatology. It has a good tolerance profile without known increased risk of cancer. We report a case of nodular melanoma with a 4.8 mm Breslow thickness that appeared after 2 years of rituximab in a 45-year-old patient with non-Hodgkin lymphoma. Fifteen additional rituximab-associated melanoma cases in 13 patients have been identified in the literature and in the EudraVigilance database. These patients were treated for various indications and had melanomas, often aggressive, initially diagnosed at a metastatic stage in 31% of cases. Our work raises the question of rituximab accountability in melanoma onset in these immunosuppressed patients. A dermatological monitoring seems necessary in patients treated with rituximab, especially in case of risk factors for melanoma. In case of individual melanoma history, the benefit/risk ratio of initiating rituximab therapy should be carefully assessed. PMID:23941917

Peuvrel, L; Chiffoleau, A; Quéreux, G; Brocard, A; Saint-Jean, M; Batz, A; Jolliet, P; Dréno, B

2013-01-01

215

Angiogenesis and Progression in Human Melanoma  

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Full Text Available In tumor growth, angiogenesis, the process of new-formation of blood vessels from pre-existing ones, is uncontrolled and unlimited in time. The vascular phase is characterized by the new-formation of vascular channels that enhances tumor cell proliferation, local invasion and hematogenous metastasis. Human malignant melanoma is a highly metastatic tumor with poor prognosis, and high resistance to treatment. Parallel with progression, melanoma acquires a rich vascular network, whereas an increasing number of tumor cells express the laminin receptor, which enables their adhesion to the vascular wall, favouring tumor cell extravasation and metastases. Melanoma neovascularization has been correlated with poor prognosis, overall survival, ulceration and increased rate of relapse. Secretion of various angiogenic cytokines, i.e. VEGF-A, FGF-2, PGF-1 and -2, IL-8, and TGF-1 by melanoma cells promote the angiogenic switch and has been correlated to transition from the radial to the vertical growth phase, and to the metastatic phase. Moreover, melanoma cells overexpress ?v?3, ?v?5, ?2?1 and ?5?1 integrins and release, together with stromal cells, higher amount of metalloproteases that increasing their invasive potential and angiogenesis. Basing on these observations, different molecular targets of antiangiogenic molecules has be recognized and various antiangiogenic agents are currently in preclinical and clinical trials for melanoma.

A. Vacca

2010-01-01

216

Desmoplastic melanoma with sarcomatoid dedifferentiation.  

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Desmoplastic melanoma (DM) is a variant of melanoma, which typically affects chronically sun-damaged skin of elderly patients. Pure DM displays a low density of fusiform melanocytes in a collagen-rich matrix. In mixed DM, tumor cell density is higher, and parts of the tumor lack abundant stromal fibrosis. Both pure and mixed DMs usually express S100 protein homogenously. We report herein an unusual biphenotypic tumor characterized by the association of a pure DM with an undifferentiated solid spindle cell nodule. It occurred on the scalp of a 66-year-old man. A biopsy of the undifferentiated spindle cell nodule was initially interpreted at a commercial laboratory as atypical fibroxanthoma. The pure DM was seen only in the excisional specimen. All cells of the pure DM stained for S100 protein and SOX10. The adjacent solid sarcomatoid spindle cell nodule lacked expression of S100 protein, SOX10, as well as melan-A, gp100, and microphthalmia-associated transcription factor in >95% of its tumor cells. Although focal expression of melanocyte differentiation antigens in the solid tumor component made us favor a combined DM with sarcomatoid dedifferentiation, we also considered the possibility of a collision scenario, that is, a pleomorphic dermal sarcoma incidentally colliding with a DM. To further assess a possible relationship of the sarcomatoid nodule with the DM, we performed next-generation sequencing analysis on each component separately. The analysis revealed shared chromosomal copy number changes and a high number of common mutations, thereby supporting the concept of a DM with a dedifferentiated sarcomatoid component. An interesting finding is the presence of mutations of the neurofibromin 1 (NF1) gene in both tumor components. PMID:24618614

Kiuru, Maija; McDermott, Gregory; Berger, Michael; Halpern, Allan C; Busam, Klaus J

2014-06-01

217

Genética molecular aplicada ao câncer cutâneo não melanoma / Molecular genetics of non-melanoma skin cancer  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Os cânceres cutâneos não melanoma são as neoplasias malignas mais comuns em humanos. O carcinoma basocelular e o carcinoma espinocelular representam cerca de 95% dos cânceres cutâneos não melanoma, o que os torna um crescente problema para a saúde pública mundial devido a suas prevalências cada vez [...] maiores. As alterações genéticas que ocorrem no desenvolvimento dessas malignidades cutâneas são apenas parcialmente compreendidas, havendo muito interesse no conhecimento e determinação das bases genéticas dos cânceres cutâneos não melanoma que expliquem seus fenótipos, comportamentos biológicos e potenciais metastáticos distintos. Apresenta-se uma revisão atualizada da genética molecular aplicada aos cânceres cutâneos não melanoma, em especial ao carcinoma basocelular e carcinoma espinocelular, enfatizando os mais freqüentes genes e os principais mecanismos de instabilidade genômica envolvidos no desenvolvimento dessas malignidades cutâneas. Abstract in english Non-melanoma skin cancers are the most common malignant neoplasms in humans. About 95% of all non-melanoma skin cancers are represented by basal cell carcinoma and squamous cell carcinoma. Their prevalences are still increasing worldwide, representing an important public health problem. The genetic [...] alterations underlying basal cell carcinoma and squamous cell carcinoma development are only partly understood. Much interest lies in determining the genetic basis of non-melanoma skin cancers, to explain their distinctive phenotypes, biological behaviors and metastatic potential. We present here a molecular genetic update, focusing on the most frequent genes and genomic instability involved in the development and progression of non-melanoma skin cancers.

Marcos Antonio Rodrigues, Martinez; Guilherme, Francisco; Luciana Sanches, Cabral; Itamar Romano Garcia, Ruiz; Cyro, Festa Neto.

218

Genética molecular aplicada ao câncer cutâneo não melanoma Molecular genetics of non-melanoma skin cancer  

Directory of Open Access Journals (Sweden)

Full Text Available Os cânceres cutâneos não melanoma são as neoplasias malignas mais comuns em humanos. O carcinoma basocelular e o carcinoma espinocelular representam cerca de 95% dos cânceres cutâneos não melanoma, o que os torna um crescente problema para a saúde p??blica mundial devido a suas prevalências cada vez maiores. As alterações genéticas que ocorrem no desenvolvimento dessas malignidades cutâneas são apenas parcialmente compreendidas, havendo muito interesse no conhecimento e determinação das bases genéticas dos cânceres cutâneos não melanoma que expliquem seus fenótipos, comportamentos biológicos e potenciais metastáticos distintos. Apresenta-se uma revisão atualizada da genética molecular aplicada aos cânceres cutâneos não melanoma, em especial ao carcinoma basocelular e carcinoma espinocelular, enfatizando os mais freqüentes genes e os principais mecanismos de instabilidade genômica envolvidos no desenvolvimento dessas malignidades cutâneas.Non-melanoma skin cancers are the most common malignant neoplasms in humans. About 95% of all non-melanoma skin cancers are represented by basal cell carcinoma and squamous cell carcinoma. Their prevalences are still increasing worldwide, representing an important public health problem. The genetic alterations underlying basal cell carcinoma and squamous cell carcinoma development are only partly understood. Much interest lies in determining the genetic basis of non-melanoma skin cancers, to explain their distinctive phenotypes, biological behaviors and metastatic potential. We present here a molecular genetic update, focusing on the most frequent genes and genomic instability involved in the development and progression of non-melanoma skin cancers.

Marcos Antonio Rodrigues Martinez

2006-10-01

219

Melanoma  

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Full Text Available ... sometimes necessary. The doctor also does a careful physical exam and, depending on the ... the doctor may also use chemotherapy, biological therapy, or radiation therapy. The doctor may decide to ...

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Full Text Available ... parts of the body such as the liver, lungs, or brain. In such cases, the cancer cells in the n This document is for ... nearby lymph node or nearby tissue. • Stage IV: Cancer cells have spread to the lungs or other nearby organs, skin areas, or lymph ...

 
 
 
 
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Full Text Available ... Education Institute, Inc. www.X-Plain.com oc180205 Last reviewed: 07/07/2011 1 What is Cancer? ... Education Institute, Inc. www.X-Plain.com oc180205 Last reviewed: 07/07/2011 2 Changes in chromosomes ...

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Full Text Available ... the thickness of the tumor, may order chest X-rays; blood tests; and scans of the liver, bones, ... fever, or weakness. Radiation Therapy uses high-energy rays to kill ... X Doctors believe that the increase in cases of ...

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Full Text Available ... for your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X-Plain.com oc180205 Last reviewed: 07/07/2011 5 This document is for informational purposes and is not intended to be a substitute ...

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Full Text Available ... sunlight, injury, and infection. It helps regulate body temperature, stores water and fat, and produces vitamin D. ... these glands produce sweat, which helps regulate body temperature. Other dermis glands produce sebum, an oily substance ...

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Full Text Available ... reach the skin's surface through tiny openings called pores. This document is for informational purposes and is ... It travels through special vessels and bean-shaped structures called lymph nodes. Cancer treatments are used to ...

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Full Text Available ... like cells called squamous cells. Round cells, called basal cells, lie under the squamous cells in the epidermis. ... Last reviewed: 07/07/2011 1 What is Cancer? The body is made up of very small ...

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Full Text Available ... very tired and these drugs can cause a headache, muscle aches, a fever, or weakness. Radiation Therapy ... had one or more severe sunburns as a child or teenager 6. Having fair skin that burns ...

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Full Text Available ... through special vessels and bean-shaped structures called lymph nodes. Cancer treatments are used to kill or control ... covering of the brains, meninges, the digestive tract, lymph nodes, or other areas where melanocytes are found. This ...

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Full Text Available ... body temperature, stores water and fat, and produces vitamin D. Epidermis Dermis The skin has 2 main ... to become red, tender, and itchy. The side effects of cancer treatment mainly depend on the type ...

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Full Text Available ... radiation therapy, or a combination of these methods. Biological Therapy (Interferon and Interleukin-2) Some patients with ... to become red, tender, and itchy. The side effects of cancer treatment mainly depend on the type ...

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Melanoma  

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Full Text Available ... also discusses some prevention tips. Skin Anatomy The skin is the body's largest organ. It protects us against heat, sunlight, injury, and infection. It helps regulate body temperature, stores ...

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Full Text Available ... red, tender, and itchy. The side effects of cancer treatment mainly depend on the type and extent of treatment. Side effects may not be the same for everyone, and they may change from one treatment to the next. Prevention & Risk Factors X Doctors believe that the increase ...

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Full Text Available ... 2011 6 Removal of nearby lymph nodes for examination under a microscope is sometimes necessary. The doctor also does a careful physical exam and, depending on the thickness of the ...

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Full Text Available ... parts of the body such as the liver, lungs, or brain. In such cases, the cancer cells ... Stage IV: Cancer cells have spread to the lungs or other nearby organs, skin areas, or lymph ...

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Full Text Available ... recommendation for any particular treatment plan. Like any printed material, it may become out of date over ... This document is for informational purposes and is not intended ...

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Full Text Available ... helps regulate body temperature. Other dermis glands produce sebum, an oily substance that helps keep the skin from drying out. Sweat and sebum reach the skin's surface through tiny openings called ...

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Full Text Available ... oc180205 Last reviewed: 07/07/2011 1 What is Cancer? The body is made up of very small cells. Normal cells ... not invade nearby tissue and body parts, it is called a benign tumor, or non-cancerous growth. ...

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Full Text Available ... tan may be present. Areas of white, gray, red, pink, or blue may also be seen. Diameter ... the skin in the treated area to become red, tender, and itchy. The side effects of cancer ...

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Full Text Available ... reported to a doctor or nurse right away. Diagnosis & Staging If the doctor suspects that a spot ... is the only way to make a definite diagnosis. In a biopsy, the doctor tries to remove ...

 
 
 
 
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Full Text Available ... an SPF (sun protection factor) of 30 or higher provide high protection against sunburn. Sunglasses that have ... for your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X-Plain.com oc180205 Last ...

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Full Text Available ... glands produce sweat, which helps regulate body temperature. Other dermis glands produce sebum, an oily substance that ... called skin cancer, even if it spreads to other places in the body. Although doctors can locate ...

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Full Text Available ... clear fluid produced by the body that drains waste from cells. It travels through special vessels and ... a fever, or weakness. Radiation Therapy uses high-energy rays to kill cancer cells. Radiation is not ...

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Full Text Available ... a doctor or a healthcare professional for your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X-Plain.com oc180205 ... a doctor or a healthcare professional for your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X-Plain.com oc180205 ...

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Melanoma  

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Full Text Available ... the body’s natural defense (immune system response) against cancer. These drugs commonly cause a rash or swelling. You may feel very tired and these drugs can cause a headache, muscle aches, a fever, or weakness. ... high-energy rays to kill cancer cells. Radiation is not a common treatment for ...

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Melanoma  

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Full Text Available ... and a cancerous mole? The following sections discuss 4 A-B-C-D tips: asymmetry, border, color, ... eraser of a pencil (5 mm or 1/4 inch); non-cancerous moles are smaller. Non-cancerous ...

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Full Text Available ... or a healthcare professional for your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X- ... or a healthcare professional for your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X- ...

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Full Text Available ... a controlled way. Sometimes cells keep dividing and growing without normal controls, causing an abnormal growth called ... treatments are used to kill or control abnormally growing cancerous cells. Cancers in the body are given ...

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Full Text Available ... People also can check their own skin for new growths or other changes. Changes in the skin ... a fever, or weakness. Radiation Therapy uses high-energy rays to ... Artificial sources of UV radiation, such as sunlamps and tanning ...

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Full Text Available ... body's largest organ. It protects us against heat, sunlight, injury, and infection. It helps regulate body temperature, ... natural color. When skin is exposed to the sun, melanocytes produce more pigment, causing the skin to ...

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Full Text Available ... your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X-Plain.com oc180205 Last reviewed: 07/07/2011 1 What is Cancer? The body is made up of very small ...

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Full Text Available ... and infection. It helps regulate body temperature, stores water and fat, and produces vitamin D. Epidermis Dermis ... clear fluid produced by the body that drains waste from cells. It travels through special vessels and ...

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Full Text Available ... the body's largest organ. It protects us against heat, sunlight, injury, and infection. It helps regulate body ... a doctor or a healthcare professional for your specific condition. ©1995-2011, The Patient Education Institute, Inc. ...

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Full Text Available ... begins in the skin will always be called skin cancer, even if it spreads to other places in ... chemicals, or other factors. In the case of skin cancer, sunlight causes damage to the chromosomes, leading to ...

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Melanoma  

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Full Text Available ... body's largest organ. It protects us against heat, sunlight, injury, and infection. It helps regulate body temperature, ... other factors. In the case of skin cancer, sunlight causes damage to the chromosomes, leading to cancer. ...

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Full Text Available ... Last reviewed: 07/07/2011 1 What is Cancer? The body is made up of very small ... cells, it is called a malignant tumor, or cancer. Cancer can sometimes be life-threatening. Lymph System ...

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Full Text Available ... therapy, or a combination of these methods. Biological Therapy (Interferon and Interleukin-2) Some patients with advanced ... headache, muscle aches, a fever, or weakness. Radiation Therapy uses high-energy rays to kill cancer cells. ...

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Full Text Available ... identified. Cells contain hereditary or genetic materials called chromosomes. Chromosomes control the growth of cells. Cancer always arises from changes that occur in the chromosomes. When the chromosomes in a cell become abnormal, ...

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Full Text Available ... these glands produce sweat, which helps regulate body temperature. Other dermis glands produce sebum, an oily substance that helps keep the skin from drying out. Sweat and sebum reach the skin's surface through tiny openings called pores. This document is ...

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Full Text Available ... that drains waste from cells. It travels through special vessels and bean-shaped structures called lymph nodes. ... for your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X-Plain.com oc180205 Last ...

 
 
 
 
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Full Text Available ... or cancer. Cancer can sometimes be life-threatening. Lymph System Cancerous cells sometimes spread to different parts of the body through blood vessels and lymph channels. Lymph is a clear fluid produced by ...

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Full Text Available ... called squamous cells. Round cells, called basal cells, lie under the squamous cells in the epidermis. The ... black area. Most people have moles. Moles are groups of melanocytes that form an abnormal growth. However, ...

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Full Text Available ... had one or more severe sunburns as a child or teenager 6. Having fair skin that burns ... for your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X-Plain.com oc180205 Last ...

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Full Text Available ... of a doctor or healthcare professional or a recommendation for any particular treatment plan. Like any printed ... of a doctor or healthcare professional or a recommendation for any particular treatment plan. Like any printed ...

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Full Text Available ... for your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X-Plain.com oc180205 Last ... for your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X-Plain.com oc180205 Last ...

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Full Text Available ... also discusses some prevention tips. Skin Anatomy The skin is the body's largest organ. It protects us against heat, sunlight, injury, and infection. It helps regulate body temperature, stores water and ...

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Full Text Available ... for any particular treatment plan. Like any printed material, it may become out of date over time. ... always be identified. Cells contain hereditary or genetic materials called chromosomes. Chromosomes control the growth of cells. ...

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Full Text Available ... the body that drains waste from cells. It travels through special vessels and bean-shaped structures called ... material, it may become out of date over time. It is important that you rely on the ...

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Full Text Available ... tan, or darken. The dermis contains blood vessels, lymphatic vessels, hair follicles, and glands. Some of these ... during surgery because cancer can spread through the lymphatic system. If the pathologist finds cancer cells in ...

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Full Text Available ... the body such as the liver, lungs, or brain. In such cases, the cancer cells in the n This document is for ... nearby lymph node or nearby tissue. • ... to the liver, brain, bones, and other organs. Treatment A treatment plan ...

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Full Text Available ... Sometimes cells keep dividing and growing without normal controls, causing an abnormal growth called a tumor. If ... nodes. Cancer treatments are used to kill or control abnormally growing cancerous cells. Cancers in the body ...

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Full Text Available ... the body that drains waste from cells. It travels through special vessels and bean-shaped structures called ... change from one treatment to the next. Prevention & Risk Factors X Doctors believe that the increase in ...

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Nail apparatus melanoma: a diagnostic opportunity / Melanoma do aparelho ungueal: uma oportunidade diagnóstica  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese Melanoma Maligno é uma neoplasia de alta mortalidade, sendo raro o acometimento do aparelho ungueal. Apenas 2/3 dos pacientes procuram atendimento médico devido lesão melanocítica ungueal recente, tornando o diagnóstico tardio e com prognóstico pior que do melanoma cutâneo. Descreve-se um caso de pa [...] ciente sexo feminino, apresentando lesões ulceradas com características clínico-laboratoriais compatíveis com leishmaniose tegumentar americana. No retorno após início do tratamento foi observada melanoníquia longitudinal no primeiro quirodáctilo direito. Realizada biópsia da matriz ungueal com histopatológico compatível com melanoma in situ. Melanoníquia longitudinal não é sinal específico de melanoma. A identificação das lesões suspeitas é importante tarefa dos dermatologistas. O diagnóstico incidental de melanoma ungueal in situ do caso relatado resultou em grande impacto na sobrevida da paciente. Abstract in english Malignant Melanoma is a high mortality neoplasm. The involvement of the nail apparatus is rare, with only 2 out of 3 patients seeking medical attention as the result of recent nail melanocytic lesions. This results in late diagnosis and a prognosis worse than cutaneous melanoma. We report a female, [...] presenting with ulcerative lesions with clinical and laboratory features compatible with leishmaniasis. On return after treatment initiation a longitudinal melanonychia was observed on her first right finger. Biopsy of the nail matrix was performed. Histopathology was compatible with melanoma in situ. Longitudinal melanonychia is not a specific sign for melanoma and it is important that the dermatologist should identify the suspect lesions correctly. The incidental diagnosis of nail melanoma in situ in our case significantly impacted the patient's survival.

Ana Maria, Carreño; Sílvia Rocha, Nakajima; Silmara N., Pennini; Renato, Candido Junior; Antonio Pedro Mendes, Schettini.

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Nail apparatus melanoma: a diagnostic opportunity Melanoma do aparelho ungueal: uma oportunidade diagnóstica  

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Full Text Available Malignant Melanoma is a high mortality neoplasm. The involvement of the nail apparatus is rare, with only 2 out of 3 patients seeking medical attention as the result of recent nail melanocytic lesions. This results in late diagnosis and a prognosis worse than cutaneous melanoma. We report a female, presenting with ulcerative lesions with clinical and laboratory features compatible with leishmaniasis. On return after treatment initiation a longitudinal melanonychia was observed on her first right finger. Biopsy of the nail matrix was performed. Histopathology was compatible with melanoma in situ. Longitudinal melanonychia is not a specific sign for melanoma and it is important that the dermatologist should identify the suspect lesions correctly. The incidental diagnosis of nail melanoma in situ in our case significantly impacted the patient's survival.Melanoma Maligno é uma neoplasia de alta mortalidade, sendo raro o acometimento do aparelho ungueal. Apenas 2/3 dos pacientes procuram atendimento médico devido lesão melanocítica ungueal recente, tornando o diagnóstico tardio e com prognóstico pior que do melanoma cutâneo. Descreve-se um caso de paciente sexo feminino, apresentando lesões ulceradas com características clínico-laboratoriais compatíveis com leishmaniose tegumentar americana. No retorno após início do tratamento foi observada melanoníquia longitudinal no primeiro quirodáctilo direito. Realizada biópsia da matriz ungueal com histopatológico compatível com melanoma in situ. Melanoníquia longitudinal não é sinal específico de melanoma. A identificação das lesões suspeitas é importante tarefa dos dermatologistas. O diagnóstico incidental de melanoma ungueal in situ do caso relatado resultou em grande impacto na sobrevida da paciente.

Ana Maria Carreño

2013-04-01

277

Melanoma de corpo ciliar e coróide: relato de caso / Choroidal and ciliary body melanoma: case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Melanomas oculares correspondem a 5% de todos os melanomas e 85% deles têm origem no trato uveal. Melanoma uveal é o tumor maligno intraocular primário mais comum no adulto. Relatamos neste artigo um caso de melanoma uveal em paciente, sexo feminino, 31 anos, com quadro de fotopsia, hiperemia e baix [...] a da acuidade visual no olho esquerdo com evolução de quatro meses. Apresentava ao exame oftalmológico acuidade visual menor que 20/400, grande massa tumoral na região nasal retroiriana, com deslocamento anterior do cristalino, estreitamento da câmara anterior e descolamento seroso da retina. A ecografia sugeriu tratar-se de grande massa tumoral suspeita de melanoma de coróide com invasão do corpo ciliar. A confirmação diagnóstica foi possível por meio do exame anatomopatológico. Abstract in english Ocular melanomas correspond to 5% of all melanomas and 85% of them have its origin in the uveal tract. Uveal melanoma is the most commom primary intraocular malignant tumor in the adult. In this article, a case of uveal melanoma in a 31 year-old female patient, with photopsia, hyperemia and low visu [...] al acuity in the left eye with evolution of 4 months is presented. In the ophthalmologic examination, visual acuity was lower than 20/400, a large tumoral mass was noted at the nasal region behind the iris with anterior lens displacement, anterior chamber narrowing and serous retinal detachment. The ocular echography suggested a large tumoral mass as a choroidal melanoma extending to the ciliary body. The confirmation diagnosis was possible through the histopathologic examination.

Aline Amaral Fulgêncio da, Cunha; Nara Helena Teixeira, Rodrigues; Grazziella Acácio e, Almeida; Bruno Carvalho, Picanço; João Agostini, Netto.

2010-04-01

278

Can We Inherit Skin Cancers Other Than Melanoma?  

Science.gov (United States)

... a dermatologist. With early detection and treatment, even melanoma has a 95% cure rate. Basal cell nevus ... condition die when a skin cancer, such as melanoma or squamous cell carcinoma, spreads. To protect a ...

279

Dysplastic Nevi and Hereditary Melanoma - A Program for Clinicians.  

Science.gov (United States)

The video describes the natural history of normal nevi, dysplastic nevi, and cutaneous melanoma, and outlines a program for the examination, management, and counselling of patients at high risk of melanoma. It is designed for clinicians involved in the ma...

1994-01-01

280

Dysplastic Nevi and Melanoma-A Program for Pathologists.  

Science.gov (United States)

The video describes in detail the clinical and light microscopic features of the dysplastic nevus, a specific melanoma precursor lesion, and the management recommendations for persons at increased risk of melanoma from these lesions. The primary audience ...

1994-01-01

 
 
 
 
281

Common Moles, Dysplastic Nevi, and Risk of Melanoma  

Science.gov (United States)

A fact sheet about moles and how some moles may be related to melanoma, which is the most serious type of skin cancer. The fact sheet includes photos of differences between moles and cancer, and discusses risk factors for melanoma.

282

Melanoma after laser therapy of pigmented lesions - circumstances and outcome  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The use of laser therapy in the treatment of pigmented lesions is a controversial issue as it can delay melanoma diagnosis and may negatively impact mortality. Few cases of melanoma after laser therapy have been reported. It is still unknown whether melanoma can be induced by lasers. We discuss the outcomes of twelve patients presenting with melanoma subsequent to previous treatment with laser. In four patients, a skin biopsy was performed before laser treatment. Histology was re-evaluated by...

Zipser, M. C.; Mangana, J.; Oberholzer, P. A.; French, L. E.; Dummer, R.

2010-01-01

283

Dermoscopy of Scalp Melanoma: Report of Three Cases  

Directory of Open Access Journals (Sweden)

Full Text Available Scalp melanoma is rare and often late-discovered because of its unusual position. As a consequence, its prognosis is poorer than melanoma on other body sites and only few clinical reports about its dermoscopic pattern have been published. In this paper, we report three clinical cases of scalp melanoma with photographic documentation and dermoscopic images, in order to improve the early detection of scalp melanoma.

Antonella Tosti

2010-08-01

284

Primary bilateral malignant melanoma of the lower limbs  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant melanoma is the eighth most common cancer in European women. Its incidence is increasing rapidly and it has been demonstrated that this is related to sun exposure. Although few cases of bilateral uveal or choroidal melanoma are described in literature, there are no cases reporting bilateral cutaneous malignant melanoma. We report a singular case of a 43-year-old woman with two primary bilateral melanomas localized on the flexural surface of both legs.

Antonello Baldo

2011-08-01

285

Pyrophosphorolysis detects B-RAF mutations in primary uveal melanoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

PURPOSE. Mutations in the genes that control cell proliferation in cutaneous melanoma are generally uncommon in uveal melanoma. Despite the absence of known activating mutations, the RAF-MEK-ERK, or mitogen-activated protein kinase (MAPK), pathway is usually activated in uveal melanoma. An assay with increased potential to identify mutations is now available, and this study was therefore conducted to reanalyze uveal melanoma cell lines and primary tumors for this mutation. METHODS. Eleven uve...

Maat, W.; Kilic, E.; Luyten, G. P. M.; Klein, J. E. M. M.; Jager, M. J.; Gruis, N. A.; Velden, P. A.

2008-01-01

286

Absence of BRAF mutations in UV-protected mucosal melanomas  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background: Mutations in BRAF have recently been identified in a significant percentage of primary and metastatic cutaneous malignant melanomas. As ultraviolet (UV) exposure may play a role in the development of cutaneous melanoma lesions with BRAF mutations, BRAF mutation frequency in melanomas arising in sites protected from sun exposure may be lower than those from sun-exposed areas. Thus, we determined the BRAF mutation frequency in a panel of 13 mucosal melanomas and compared those data ...

Edwards, R.; Ward, M.; Wu, H.; Medina, C.; Brose, M.; Volpe, P.; Nussen-lee, S.; Haupt, H.; Martin, A.; Herlyn, M.; Lessin, S.; Weber, B.

2004-01-01

287

Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases.  

Science.gov (United States)

Murine model systems are critically required tools for the investigation of unknown mechanisms of melanoma development and metastasis and for developing more efficient therapies. The Tg(Grm1)EPv melanoma mouse model is characterized by spontaneous development of pigmented cutaneous melanomas at hairless skin regions, with a short latency and 100% penetrance. Local metastasis was described in initial analyses; however, melanoma cells were not observed in distant organs. Here, we demonstrate that the established Tg(Grm1)EPv melanoma mouse model exhibits more extensive metastasis into distant organs than previously described. Disseminated cells undergo phenotypic changes, as we observed high numbers of non-pigmented Grm1-expressing melanoma cells within distant organs. As such changes during metastasis are common in human melanoma, our findings demonstrate that this mouse model represents an even more useful tool to study unknown mechanisms of metastasis in human melanoma than previously assumed. PMID:22882420

Schiffner, Susanne; Chen, Suzie; Becker, Jürgen C; Bosserhoff, Anja-Katrin

2012-10-01

288

Solar radiation and malignant melanoma of the skin  

International Nuclear Information System (INIS)

Several observations suggest that a majority of cases of malignant melanoma of the skin are linked to sun exposure. Evidence includes higher occurrence of melanoma on anatomic areas heavily exposed during recreation, development of melanoma more frequently in lightly pigmented persons, and correlation of melanoma incidence and mortality with proximity to the equator. The role of the sun exposure in the pathogenesis of melanoma remains unclear, however. Many cases of melanoma may be related to heavy doses of solar radiation received during recreation. Chronic sun exposure is not so clearly linked to the development of melanoma (except in the uncommon lentigo maligna variety). Sunspot cycles have been associated with changes in melanoma incidence; an excess of melanoma cases has been observed every 9 to 12 years after peak sunspot activity. These excess cases may be caused by more intense exposure to solar ultraviolet radiation during sunspot maxima, perhaps related to changes in the stratospheric ozone layer. These epidemiologic and clinical clues suggest that many cases of melanoma are related to sun exposure triggering the appearance of clinically evident melanoma. In this regard, solar radiation behaves as a cocarcinogen or promoter, rather than a dose-dependent carcinogen. These observations also suggest that other factors may be involved in the pathogenesis of melanoma, e.g., nevi, heredity, or exposure to chemical carcinogens

289

Caring for patients with melanoma in the primary care setting.  

Science.gov (United States)

The incidence of melanoma is steadily rising and mortality continues to increase. This article describes types of melanoma and the role of primary care providers in the long-term management and follow-up of patients diagnosed with melanoma. PMID:24901732

Rea, Mary; Perrino, Laura; Sheets, Victoria; McDaniel, M Jane

2014-07-01

290

Cytotoxic T lymphocyte responses against melanocytes and melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Vitiligo is a common toxicity associated with immunotherapy for melanoma. Cytotoxic T lymphocytes (CTLs against melanoma commonly target melanoma-associated antigens (MAAs which are also expressed by melanocytes. To uncouple vitiligo from melanoma destruction, it is important to understand if CTLs can respond against melanoma and melanocytes at different levels. Methods To understand the dichotomous role of MAA-specific CTL, we characterized the functional reactivities of established CTL clones directed to MAAs against melanoma and melanocyte cell lines. Results CTL clones generated from melanoma patients were capable of eliciting MHC-restricted, MAA-specific lysis against melanocyte cell lines as well as melanoma cells. Among the tested HLA-A*0201-restricted CTL clones, melanocytes evoked equal to slightly higher degranulation and cytolytic responses as compared to melanoma cells. Moreover, MAA-specific T cells from vaccinated patients responded directly ex vivo to melanoma and melanocytes. Melanoma cells express slightly higher levels of MART-1 and gp100 than melanocytes as measured by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR and immunohistochemistry. Conclusions Our data suggest that CTLs respond to melanoma and melanocytes equally in vitro and directly ex vivo.

Schwartz Erich J

2011-07-01

291

Ocular malignant melanoma in pregnancy: Is a happy ending possible?  

Directory of Open Access Journals (Sweden)

Full Text Available Uveal, especially choroidal melanoma is the most common ocular melanoma. There is no clear evidence that pregnancy impacts its development. Enucleation is generally indicated for advanced tumors. Five-year mortality rate is 53% in patients with large melanomas (>8 mm.

Grgi? Zorka

2009-01-01

292

Correlation of histopathological patterns in cutaneous melanoma with BRAF mutations Correlação de padrões histopatológicos de melanomas cutâneos com mutações BRAF  

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INTRODUCTION: Mutations on BRAF gene located on chromosome 7q are the most frequently found in cutaneous melanomas (60%-80%). The only study correlating histopathological patterns of cutaneous melanomas with the presence of BRAF mutations was undertaken by Viros et al. in 2008. The authors observed that morphological features of melanomas are associated with BRAF mutations. OBJECTIVES: To correlate histopathological patterns in cutaneous melanoma with the presence of BRAF mutations in order t...

Juliana Elizabeth Jung; Jorge Eduardo Fouto Matias; Norbert Blödorn-Schlicht; Falk, Thomas M.; Almut Böer

2010-01-01

293

Overexpression of melanoma inhibitory activity (MIA) enhances extravasation and metastasis of A-mel 3 melanoma cells in vivo  

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The secreted MIA protein is strongly expressed by advanced primary and metastatic melanomas but not in normal melanocytes. Previous studies have shown that MIA serum levels correlate with clinical tumour progression in melanoma patients. To provide direct evidence that MIA plays a role in metastasis of malignant melanomas, A-mel 3 hamster melanoma cells were transfected with sense- and antisense rhMIA cDNA and analysed subsequently for changes in their tumorigenic and metastatic potential. En...

Guba, M.; Bosserhoff, A-k; Steinbauer, M.; Abels, C.; Anthuber, M.; Jauch, K-w

2000-01-01

294

Melanocyte and Melanoma Cell Activation by Calprotectin  

Science.gov (United States)

Calprotectin, a heterodimer of S100A8 and S100A9, is a proinflammatory cytokine released from ultraviolet radiation-exposed keratinocytes. Calprotectin binds to Toll-like receptor 4, the receptor for advanced glycation end-products, and extracellular matrix metalloproteinase inducer on target cells to stimulate migration. Melanocytes and melanoma cells produce little if any calprotectin, but they do express receptors for the cytokine. Thus, keratinocyte-derived calprotectin has the potential to activate melanocytes and melanoma cells within the epidermis in a paracrine manner. We examined the ability of calprotectin to stimulate proliferation and migration in normal human melanocytes and melanoma cells in vitro. We first showed, by immunofluorescence and quantitative RT-PCR, that the melanocytic cells employed expressed a calprotectin receptor, the receptor for advanced end-products. We then demonstrated that calprotectin significantly enhanced proliferation, migration, and Matrigel invasion in both normal human melanocytes and melanoma cells. Thus, calprotectin is one of the numerous paracrine factors released by ultraviolet radiation-exposed keratinocytes that may promote melanomagenesis and is a potential target for melanoma prevention or therapy.

Shirley, Stephanie H.; Robbins, Paige O.; Kusewitt, Donna F.

2014-01-01

295

Melanocyte and melanoma cell activation by calprotectin.  

Science.gov (United States)

Calprotectin, a heterodimer of S100A8 and S100A9, is a proinflammatory cytokine released from ultraviolet radiation-exposed keratinocytes. Calprotectin binds to Toll-like receptor 4, the receptor for advanced glycation end-products, and extracellular matrix metalloproteinase inducer on target cells to stimulate migration. Melanocytes and melanoma cells produce little if any calprotectin, but they do express receptors for the cytokine. Thus, keratinocyte-derived calprotectin has the potential to activate melanocytes and melanoma cells within the epidermis in a paracrine manner. We examined the ability of calprotectin to stimulate proliferation and migration in normal human melanocytes and melanoma cells in vitro. We first showed, by immunofluorescence and quantitative RT-PCR, that the melanocytic cells employed expressed a calprotectin receptor, the receptor for advanced end-products. We then demonstrated that calprotectin significantly enhanced proliferation, migration, and Matrigel invasion in both normal human melanocytes and melanoma cells. Thus, calprotectin is one of the numerous paracrine factors released by ultraviolet radiation-exposed keratinocytes that may promote melanomagenesis and is a potential target for melanoma prevention or therapy. PMID:25197574

Shirley, Stephanie H; von Maltzan, Kristine; Robbins, Paige O; Kusewitt, Donna F

2014-01-01

296

Vemurafenib for the treatment of melanoma.  

LENUS (Irish Health Repository)

Metastatic melanoma is an aggressive disease resistant to chemotherapy. Recent clinical trials have reported improved survival for two novel agents; ipilimumab, a humanized, IgG1 monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and vemurafenib , a BRAF (v-raf murine sarcoma viral oncogene homolog B1) inhibitor targeting an activating mutation in the serine-threonine-protein kinase BRAF gene. AREAS COVERED: The authors reviewed preclinical and clinical data examining the safety of vemurafenib in melanoma. MEDLINE and EMBASE were searched using the medical subject heading \\'vemurafenib\\' and the following text terms: melanoma, BRAF inhibition, vemurafenib. This review provides the reader with an overview of current data examining the efficacy and safety of vemurafenib in metastatic melanoma. EXPERT OPINION: Vemurafenib is an oral agent licensed for patients with BRAF V600E mutation-positive inoperable and metastatic melanoma. The most common adverse effects observed in Phase III clinical trials were dermatological events, arthralgia and fatigue. Specific dermatological toxicities included development of cutaneous squamous cell cancers and keratoacanthomas. Prolongation of the QT interval was also reported. Regular dermatological assessments and electrocardiograms are recommended. Ongoing trials are examining vemurafenib in both the adjuvant setting and metastatic setting in combination with ipilimumab and MEK inhibitors (mitogen-activated protein kinase\\/extracellular signal-regulated kinase). Understanding and overcoming mechanisms of resistance to BRAF inhibitors is the focus of ongoing research.

Jordan, Emmet John

2012-12-01

297

A Hidden Threat: Subungual Melanoma in Hand  

Directory of Open Access Journals (Sweden)

Full Text Available Subungual melanoma, a relatively uncommon disease, has a worse prognosis than cutaneous melanoma in other sites. Both this life-threatening disease and its treatment cause cosmetic and functional impairment to the patient. The diagnosis is often delayed and resulting an advanced disease at presentation. The important clinical manifestation, diagnosis and latest treatments for subungual melanoma are reviewed. Electronic databases of Medline, PubMed, and the Cochrane library were searched with the key word “subungual melanoma”. A clinical scoring system is proposed by the authors to stratify patients to undergo biopsy, making earlier diagnosis of this disease possible. The latest trend of treatment involves wide local excision at a more distal level of the affected digit, in contrast to radical amputation of the digit in the past. Studies have shown that this does not decrease the survival nor increase local recurrence, but reduces the functional impairment for the patient. This review aims to summarise the approach to subungual melanoma for clinicians, so that they can recognise and diagnose this disease early and generate the best functional and cosmetic outcome for the patients.

C. P. Lung

2012-02-01

298

Deregulation of protein methylation in melanoma.  

Science.gov (United States)

Loss of methylthioadenosine phosphorylase (MTAP) expression and a concomitant accumulation of 5'-methyl-thioadenosine (MTA) characterise several tumour entities including malignant melanoma. MTA affects cellular signalling, proliferation and migration not only of cancer but also surrounding cells including lymphocytes and stromal fibroblasts. The mode of action of MTA is still not known. Interestingly, MTA is a known potent inhibitor of protein arginine methyltransferases (PRMTs) and is used as a tool in studying activity and impact of PRMTs. This study aimed at analysing PRMTs in melanoma and the potential impact of MTA on tumourigenesis. Our findings demonstrate that expression of PRMT4/CARM1 and PRMT6 is deregulated in melanoma, whereas expression of the remaining PRMTs stays unchanged. General PRMT activity and, consequently, symmetric and asymmetric protein methylation are reduced significantly in melanoma cells and tissues. This is due to a loss of MTAP expression and accumulation of MTA. Reduction of protein methylation by MTA affects cell signalling and leads, for example, to an activation of extracellular signal-regulated kinase (ERK) activity. The effects of endogeneous MTA on PRMTs as presented in this study can strongly support the migratory and invasive phenotype of melanoma cells. PMID:23265702

Limm, Katharina; Ott, Corinna; Wallner, Susanne; Mueller, Daniel W; Oefner, Peter; Hellerbrand, Claus; Bosserhoff, Anja-Katrin

2013-04-01

299

Radioimmunodetection and radioimmunotherapy of malignant melanoma  

International Nuclear Information System (INIS)

Radioimmunodetection utilizing monoclonal antibodies to various melanoma-associated surface antigens has been studied by several investigators during the past ten years. In the early trials, antibodies were labeled with 131I or 111In, but now 99mTc is almost exclusively used because of its more favorable energy for gamma camera imaging. Excellent specificity has been achieved in most studies, whereas sensitivity has been less good. In a recent European multicenter study on 493 patients sensitivity was 79% and specificity 96%. In this largest study on melanoma so far performed many previously unknown metastatic deposits were identified indicating that radioimmunodetection has a role in the management of metastatic disease. The clinical utility of immunoscintigraphy in localization of regional lymph node metastases has been documented in several investigations in recent years, indicating that this method can be used in the preoperative evaluation of patients. Radioimmunodetection has also been successfully used in the differential diagnosis of ocular lesions. However, conclusive evidence of improved patient outcome resulting from the earlier detection of melanoma lesions by immunoscintigraphy is still lacking. Anti-melanoma antibodies labeled with alpha- and beta-emitting isotopes are potential therapeutic agents, but so far there is little clinical experience with radioimmunotherapy of metastatic melanoma. (orig.)

300

Cure of malignant melanoma by single thermal neutron capture treatment using melanoma-seeking compounds  

International Nuclear Information System (INIS)

Since not only malignant melanomas but also many kinds of human cancers, for example thyroid cancer and squamous cell carcinoma, synthesize their specific protein, much attention has been paid to the establishment of selective thermal neutron capture treatment of malignant melanoma as a prototype of such cancer cells. This paper presents 10B chlorpromazine compounds and 10B1-para-boronophenylalanine (10B1-BPA) as tumor-seeking 10B compounds which themselves possess selective affinity for the specific metabolic activity of the target cancer cells. An overview of the following studies on the effects of 10B1-BPA in the thermal neutron capture treatment of melanoma is provided: 1) in vitro studies on specific enhanced melanoma cell killing effects of 10B1-BPA; 2) in vivo studies on therapeutic effects of 10B1-BPA using melanoma-bearing hamsters; and 3) preclinical therapeutic experiments using spontaneously occurring malignant melanoma in Duroc pig skin, including experiments in which melanoma was successfully cured. (Namekawa, K.)

 
 
 
 
301

Animal-Type Melanoma: A Rare Type of Malignant Melanoma with an Indolent Clinical Behaviour  

Directory of Open Access Journals (Sweden)

Full Text Available Animal-type melanoma is an exceedingly rare histological variant of melanoma in humans. The name was coined to reflect similar histological features to melanomas in grey horses. We present a case of animal-type melanoma. The neoplastic cells were heavily pigmented with an epithelioid morphology, round nuclei and prominent eosinophilic nucleoli. Only occasional mitotic figures were identified. The tumour cells had diffuse and nodular growth patterns with involvement of the dermis and the subcutaneous tissue. The patient had a “benign cellular blue naevus” excised 9 years earlier from the same site. Review of the previous case revealed heavily pigmented epithelioid cells with similar morphology to the current case. Nuclear pleomorphism was minimal and only a single mitotic figure was present. The lesion extended to the margins of excision. The diagnosis of animal-type melanoma was made on the current case and on the previously misdiagnosed case. Recurrence of this case nine years following incomplete excision further supports the hypothesis that animal-type melanoma is a distinct histological type of malignant melanoma with an indolent clinical course.

Muna Sabah

2007-01-01

302

Report from the Melanoma Independent Board First Melanoma MIB Conference, 21-22 October 2013.  

Science.gov (United States)

The Melanoma Independent Board (MIB) held its first conference from 21 to 22 October, 2013, in Rome, Italy. Like the MIB itself, the conference brought together specialists from all aspects of cancer care: doctors, patient associations, journalists, and representatives from local government, hospitals, and pharma to encourage an interdisciplinary discussion on the future of melanoma. It was hoped that the conference would be an opportunity for all participants to see and understand each other's points of view. In memoriam of melanoma pioneer Natalie Cascinelli, the conference focussed on innovation and sustainability as well as the latest drug developments. PMID:25075214

Testori, A; Ascierto, P; Chiarion Sileni, V; De Lorenzo, F; Pelicci, Pg; Rossi, Cr

2014-01-01

303

Report from the Melanoma Independent Board First Melanoma MIB Conference, 21–22 October 2013  

Science.gov (United States)

The Melanoma Independent Board (MIB) held its first conference from 21 to 22 October, 2013, in Rome, Italy. Like the MIB itself, the conference brought together specialists from all aspects of cancer care: doctors, patient associations, journalists, and representatives from local government, hospitals, and pharma to encourage an interdisciplinary discussion on the future of melanoma. It was hoped that the conference would be an opportunity for all participants to see and understand each other’s points of view. In memoriam of melanoma pioneer Natalie Cascinelli, the conference focussed on innovation and sustainability as well as the latest drug developments. PMID:25075214

Testori, A; Ascierto, P; Chiarion Sileni, V; De Lorenzo, F; Pelicci, PG; Rossi, CR

2014-01-01

304

Confocal microscopy in the diagnosis of melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Melanoma is the most deadly form of skin cancer of melanocytic origin. The tumor has a high malignant potential and early metastasis. Prognosis is directly linked to the stage of the disease. Diagnosing thin melanoma at an early stage offers patients their best chance for survival. The crucial innovation in the early recognition of melanoma was the development of in vivo examination of the skin in high-resolution, by confocal microscopy. Confocal microscopy and its modifications provides a “virtual biopsy“, owing to melanosomes and melanin, which are a source of endogenous contrast. Confocal scanning laser microscopy (CSLM provides visualization of microanatomical structures and cellular detail in real time (pigmented keratinocytes, melanocytes, melanosomes and melanophages in the epidermis, dermoepidermal junction and superficial dermis at a resolution equivalent to the resolution of conventional microscopes. [Projekat Ministarstva nauke Republike Srbije, br. 41002

Apostolovi?-Stojanovi? Milica

2013-01-01

305

Bioelectric applications for treatment of melanoma.  

Science.gov (United States)

Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma. PMID:24281185

Beebe, Stephen J; Schoenbach, Karl H; Heller, Richard

2010-01-01

306

Bioelectric Applications for Treatment of Melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs. EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in mice. Applications of bioelectrics, using conventional electroporation and extensions of it, provide effective alternative therapies for melanoma.

Richard Heller

2010-09-01

307

Oral mucosal melanoma: a malignant trap.  

Science.gov (United States)

Oral mucosal melanomas are highly malignant tumors. The 'chameleonic' presentation of a mainly asymptomatic condition, the rarity of these lesions, the poor prognosis and the necessity of a highly specialized treatment are factors that should be seriously considered by the involved health provider. We present the case of a 75-year-old man who was referred to the Ear, Nose and Throat department. His symptoms were voice alteration and saliva drooling, progressively worsening during the last few weeks. The absence of pain was the reason for the delay of seeking medical care. The diagnosis was an oversized oral melanoma. This is an example of how the time of diagnosis and the evolution of a disease could be seriously influenced by patient's behavior. Melanomas arising from oral mucosa have poor prognosis unless they are discovered and treated early. The vigilance of the physicians is necessary to have success in this difficult task. PMID:16569245

Symvoulakis, Emmanouil K; Kyrmizakis, Dionysios E; Drivas, Emmanouil I; Koutsopoulos, Anastassios V; Malandrakis, Stylianos G; Skoulakis, Charalambos E; Bizakis, John G

2006-01-01

308

Oral mucosal melanoma: a malignant trap  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Oral mucosal melanomas are highly malignant tumors. The 'chameleonic' presentation of a mainly asymptomatic condition, the rarity of these lesions, the poor prognosis and the necessity of a highly specialized treatment are factors that should be seriously considered by the involved health provider. We present the case of a 75-year-old man who was referred to the Ear, Nose and Throat department. His symptoms were voice alteration and saliva drooling, progressively worsening during the last few weeks. The absence of pain was the reason for the delay of seeking medical care. The diagnosis was an oversized oral melanoma. This is an example of how the time of diagnosis and the evolution of a disease could be seriously influenced by patient's behavior. Melanomas arising from oral mucosa have poor prognosis unless they are discovered and treated early. The vigilance of the physicians is necessary to have success in this difficult task.

Skoulakis Charalambos E

2006-03-01

309

Malignant melanoma of the oral cavity  

Directory of Open Access Journals (Sweden)

Full Text Available Oral malignant melanoma is a rare disease. The common sites of its occurrence are the palate and gingiva with the maxillary arch being affected 80% of the time. Because of their presence at relatively obscure areas in the oral cavity, most of the malignant melanomas of the oral cavity are diagnosed at a late stage. These lesions are associated with poor prognosis. The dental clinician must therefore carefully examine the head, neck, and oral cavity, and any pigmented lesion that may exhibit growth potential must be biopsied. This article describes a case of malignant melanoma that was present in the oral cavity and briefly reviews the relevant literature that explains the nature of this lesion.

Ebenezer Jagadish

2006-01-01

310

Melanoma metastasis to the spleen: Laparoscopic approach  

Directory of Open Access Journals (Sweden)

Full Text Available We report a case of minimally invasive surgery in the management of metastasis to the spleen. A 67-year-old male patient with possible splenic soft tissue melanoma metastasis was referred to our hospital. He had a history of an excised soft tissue melanoma from his back eight months earlier, and the control abdominal computer tomography (CT scan revealed a hypodense spleen lesion. The patient underwent laparoscopic surgery to diagnose and treat the splenic lesion. The splenectomy was performed and the histological examination revealed a melanoma. The patient had a good postoperative course and was discharged on the second postoperative day. On his 12-month follow-up there was no sign of recurrence. The laparoscopic approach is a safe and effective alternative for treatment of splenic metastases.

Trindade Manoel Roberto

2009-01-01

311

Role of nuclear medicine in melanoma  

International Nuclear Information System (INIS)

Melanoma is a malignant tumour of the melanocytes presenting characteristic metabolic and biological features, which remains a difficult and important issue in oncology. As a functional modality, nuclear medicine offers a variety of possibilities to assist in the clinical management of this disease. A brief survey of currently available techniques is presented for the diagnosis, staging and follow up, either by organ imaging or by using a great spectrum of tumour-seeking radiopharmaceuticals. The role of lymphoscintigraphy in melanoma is emphasized, as well as the supportive role of nuclear medicine in the surgical theater, enabling selective lymph node dissection by the sentinel node procedure and high dose regional chemotherapy by isolated limb perfusion. Although hardly used for metastatic melanoma so far, with all its tumour-seeking approaches nuclear medicine holds a therapeutic potential for this disease as well. (orig.)

312

Role of nuclear medicine in melanoma  

Energy Technology Data Exchange (ETDEWEB)

Melanoma is a malignant tumour of the melanocytes presenting characteristic metabolic and biological features, which remains a difficult and important issue in oncology. As a functional modality, nuclear medicine offers a variety of possibilities to assist in the clinical management of this disease. A brief survey of currently available techniques is presented for the diagnosis, staging and follow up, either by organ imaging or by using a great spectrum of tumour-seeking radiopharmaceuticals. The role of lymphoscintigraphy in melanoma is emphasized, as well as the supportive role of nuclear medicine in the surgical theater, enabling selective lymph node dissection by the sentinel node procedure and high dose regional chemotherapy by isolated limb perfusion. Although hardly used for metastatic melanoma so far, with all its tumour-seeking approaches nuclear medicine holds a therapeutic potential for this disease as well. (orig.) With 4 figs., 2 tabs., 47 refs.

Hoefnagel, C.A. [Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam (Netherlands)

1998-11-01

313

Malignant melanoma in children: imaging spectrum  

International Nuclear Information System (INIS)

Objective. The objective of this study was to investigate the role of diagnostic imaging in detecting unsuspected metastatic disease in children with malignant melanoma. This has not been well studied previously. Materials and methods. We correlated imaging findings of 33 children diagnosed with melanoma with the level of invasion and clinical stage of disease. Results. Clinically undetectable metastases were identified in eight patients (25 %), four of whom had multiple metastases. All eight patients had deep lesions (Clark's level IV or V) or unknown primary sites of disease. Conclusion. Children with thick melanomas and those with unknown site of primary tumors are at increased risk of having clinically unsuspected metastases and should undergo CT of the chest, abdomen, and local-regional nodal basins at diagnosis to determine disease extent. (orig.). With 8 figs

314

Melanoma of the Hand: Current Practice and New Frontiers  

Directory of Open Access Journals (Sweden)

Full Text Available Melanoma of the hand represents a complicated clinical entity. Anatomic features of the hand create challenges in successful management of melanoma not encountered elsewhere in the body. The objectives of this article are to outline current standards for managing melanoma of the hand including diagnosis, surgical, and chemotherapeutic management. Particular emphasis will be placed on currently debated topics of the role of sentinel lymph node biopsy, the role of Mohs micrographic surgery, tissue sparing management of subungual melanoma, and the consideration of melanoma of the hand as a distinct entity based on clinical and molecular studies.

John Brad Turner

2014-03-01

315

Handheld photoacoustic microscopy to detect melanoma depth in vivo.  

Science.gov (United States)

We developed handheld photoacoustic microscopy (PAM) to detect melanoma and determine tumor depth in nude mice in vivo. Compared to our previous PAM system for melanoma imaging, a new light delivery mechanism is introduced to improve light penetration. We show that melanomas with 4.1 and 3.7 mm thicknesses can be successfully detected in phantom and in in vivo experiments, respectively. With its deep melanoma imaging ability and handheld design, this system can be tested for clinical melanoma diagnosis, prognosis, and surgical planning for patients at the bedside. PMID:25121860

Zhou, Yong; Xing, Wenxin; Maslov, Konstantin I; Cornelius, Lynn A; Wang, Lihong V

2014-08-15

316

Current Research and Development of Chemotherapeutic Agents for Melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Cutaneous malignant melanoma is the most lethal form of skin cancer and an increasingly common disease worldwide. It remains one of the most treatment-refractory malignancies. The current treatment options for patients with metastatic melanoma are limited and in most cases non-curative. This review focuses on conventional chemotherapeutic drugs for melanoma treatment, by a single or combinational agent approach, but also summarizes some potential novel phytoagents discovered from dietary vegetables or traditional herbal medicines as alternative options or future medicine for melanoma prevention. We explore the mode of actions of these natural phytoagents against metastatic melanoma.

Kyaw Minn Hsan

2010-04-01

317

Malignant melanoma of breast: a unique case with diagnostic dilemmas.  

Science.gov (United States)

Melanomas arising in the skin, mucous membranes, and eye are encountered commonly than melanomas involving the breast. Melanomas in the breast are usually metastatic. Primary melanoma of the breast is extremely rare. We report a case of malignant melanoma of breast (primary/metastatic) that presented as a breast lump in a patient with no detectable cutaneous, mucosal or ocular lesion and who is a known case of squamous cell carcinoma of the oral cavity and had relapsed twice. The unexpected challenges faced during the diagnosis prompted us to report this case. PMID:24943768

Vasudevan, Jayasudha A; Somanathan, Thara; Mathews, Anitha; Kattoor, Jayasree

2014-01-01

318

MR imaging of hemorrhagic intracerebral metastatic malignant melanoma: case report  

International Nuclear Information System (INIS)

Malignant melanoma is the third most frequent metastatic lesion to the brain. In MR examination we observe three different images corresponding to three types of the metastasis - non-hemorrhagic melanotic melanoma, non-hemorrhagic amelanotic melanoma, and hemorrhagic melanoma. Three percent to 14 % of all brain metastases are hemorrhagic by MR examinations. In the case of major bleeding the MR image of the metastasis may be covered with that of hematoma. The case report points out problems in a differential diagnosis of a solitary pathologic lesions in the brain of the hypertonic patients six years after the extirpation of the malignant melanoma on the back. (authors)

319

Melanoma biomolecules: independently identified but functionally intertwined  

Directory of Open Access Journals (Sweden)

Full Text Available The majority of patients diagnosed with melanoma present with thin lesions and generally these patients have a good prognosis. However, 5% of patients with early melanoma (< 1mm thick will have recurrence and die within 10 years, despite no evidence of local or metastatic spread at the time of diagnosis. Thus, there is a need for additional prognostic markers to help identify those patients that may be at risk of recurrent disease. Many studies and several meta-analyses have compared gene and protein expression in melanocytes, naevi, primary and metastatic melanoma in an attempt to find informative prognostic markers for these patients. However, although a large number of putative biomarkers have been described, few of these molecules are informative when used in isolation. The best approach is likely to involve a combination of molecules. We believe one approach could be to analyze the expression of a group of interacting proteins that regulate different aspects of the metastatic pathway. This is because a primary lesion expressing proteins involved in multiple stages of metastasis may be more likely to lead to secondary disease than one that does not. This review focuses on five putative biomarkers - melanoma cell adhesion molecule (MCAM, galectin-3 (gal-3, matrix metalloproteinase 2 (MMP-2, chondroitin sulfate proteoglycan 4 (CSPG4 and paired box 3 (PAX3. The goal is to provide context around what is known about the contribution of these biomarkers to melanoma biology and metastasis. Although each of these molecules have been independently identified as likely biomarkers, it is clear from our analyses that each are closely linked with each other, with intertwined roles in melanoma biology.

DanielleErinDye

2013-09-01

320

Canine olfactory detection of malignant melanoma.  

Science.gov (United States)

Our patient is a 75-year-old man who presented after his pet dog licked persistently at an asymptomatic lesion behind his right ear. Examination revealed a nodular lesion in the postauricular sulcus. Histology confirmed malignant melanoma, which was subsequently excised. Canine olfactory detection of human malignancy is a well-documented phenomenon. Advanced olfaction is hypothesised to explain canine detection of bladder, breast, colorectal, lung, ovarian, prostate and skin cancers. Further research in this area may facilitate the development of a highly accurate aid to diagnosis for many malignancies, including melanoma. PMID:24127369

Campbell, Leon Frederick; Farmery, Luke; George, Susannah Mary Creighton; Farrant, Paul B J

2013-01-01

 
 
 
 
321

Helium ion therapy for choroidal melanoma  

International Nuclear Information System (INIS)

Eighty-two patients with choroidal melanomas were treated with helium ion charged particle irradiation. Seventy-eight of 82 patients have either remained stable or demonstrated tumor shrinkage. Forty-five of 46 patients followed for at least 1 year after therapy have demonstrated tumor regression with a mean tumor shrinkage of approximately 31%. No tumor-related mortality has been observed. The most effective method of choroidal melanoma management is unclear. Charged particle external beam irradiation may be more applicable and have less ocular morbidity than either radioactive plaques or photocoagulation

322

Primary malignant melanoma of the esophagus.  

Science.gov (United States)

Primary malignant melanoma of the esophagus, first recognized as a primary tumor by de la Pava et al. in 1963, is rare. It usually presents as an aggressive polypoidal darkly colored or non-pigmented tumor in the mid to lower esophagus which may be diagnosed preoperatively by the use of immunohistochemical stains such as HMB-45 (melanoma specific antigen). The treatment of choice is surgical resection however the overall prognosis is poor with only 4 per cent of patients surviving 5 years. PMID:8799387

Craig, S R; Wallace, W H; Ramesar, K C; Cameron, E W

1996-01-01

323

Metastatic melanoma and vemurafenib: novel approaches  

Directory of Open Access Journals (Sweden)

Full Text Available Metastatic melanoma (MM presents a treatment challenge to oncologists worldwide. Dacarbazine is the first line chemotherapy treatment for MM, though the overall response rates are very poor. Recently, the v-raf murine sarcoma viral oncogene homolog B1 (BRAF V600 mutation was found to play a main role in MM. This mutation is present in 40-60% of melanoma patients. Vemurafenib is a BRAF kinase inhibitor that showed impressive results in phase I-III trials and was thus recently approved for the treatment of MM. This paper will briefly focus on vemurafenib in the treatment of MM and highlight concerns.

Ramon Andrade De Mello

2012-04-01

324

Optimizing the treatment of BRAF mutant melanoma.  

Science.gov (United States)

Selective inhibitors of the kinases BRAF and MEK for the treatment of patients with otherwise refractory BRAF mutant melanoma have demonstrated impressive efficacy, and combination treatment with these agents may prove to be even more effective. However, these drugs are not curative, mainly because of the relatively rapid development of drug resistance. Furthermore, they can produce undesired, and even unanticipated, side effects, including the emergence of neoplastic lesions harboring activating RAS mutations. Two recent reports reveal new considerations for the optimal approach to targeting this key oncogenic pathway in melanoma, highlighting the importance of combination treatment and therapeutic scheduling. PMID:25031620

Settleman, Jeff

2014-01-01

325

Late recurrence of malignant melanoma presenting with hemoptysis  

Directory of Open Access Journals (Sweden)

Full Text Available After a disease-free period of 10 years, a surgically treated case of cutaneous malignant melanoma is usually not followed up further and there is a tendency to assume that the disease is cured. Late recurrence (after 10 years of cutaneous malignant melanoma, though infrequent, has been documented well in Western countries. In our country, the malignant melanoma is still considered uncommon and there is no data regarding its late recurrence. We report a case of pulmonary malignant melanoma as a late metastatic manifestation of primary plantar malignant melanoma in a 61-year-old man who presented with hemoptysis; metastatic malignant melanoma of the lung occurred 12 years after resection of primary malignant melanoma of sole of the right foot.

Gowrinath Karanam

2010-01-01

326

Isolation and molecular characterization of circulating melanoma cells.  

Science.gov (United States)

Melanoma is an invasive malignancy with a high frequency of blood-borne metastases, but circulating tumor cells (CTCs) have not been readily isolated. We adapted microfluidic CTC capture to a tamoxifen-driven B-RAF/PTEN mouse melanoma model. CTCs were detected in all tumor-bearing mice and rapidly declined after B-RAF inhibitor treatment. CTCs were shed early from localized tumors, and a short course of B-RAF inhibition following surgical resection was sufficient to dramatically suppress distant metastases. The large number of CTCs in melanoma-bearing mice enabled a comparison of RNA-sequencing profiles with matched primary tumors. A mouse melanoma CTC-derived signature correlated with invasiveness and cellular motility in human melanoma. CTCs were detected in smaller numbers in patients with metastatic melanoma and declined with successful B-RAF-targeted therapy. Together, the capture and molecular characterization of CTCs provide insight into the hematogenous spread of melanoma. PMID:24746818

Luo, Xi; Mitra, Devarati; Sullivan, Ryan J; Wittner, Ben S; Kimura, Anya M; Pan, Shiwei; Hoang, Mai P; Brannigan, Brian W; Lawrence, Donald P; Flaherty, Keith T; Sequist, Lecia V; McMahon, Martin; Bosenberg, Marcus W; Stott, Shannon L; Ting, David T; Ramaswamy, Sridhar; Toner, Mehmet; Fisher, David E; Maheswaran, Shyamala; Haber, Daniel A

2014-05-01

327

CLINICAL AND MORPHOLOGICAL CONSIDERATIONS IN CUTANEOUS MALIGNANT MELANOMA  

Directory of Open Access Journals (Sweden)

Full Text Available 278 cases of cutaneous malignant melanoma admitted in „Emergency Clinic Hospital” Iasi between 1996-2006 have been described. Our cases showed that cutaneous malignant melanoma prevailed in females, has the highest incidence in the fourth decade, and is mostly located in lower limbs. Malignant melanoma occured on healthy skin (205 cases, congenital nevus (9 cases, preexisting nevus (29 cases, lentigo maligna (14 cases, and as a subungual form (21 cases. Our cases have been classified as lentigo maligna, superficial spreading melanoma, nodular melanoma and as melanoma arising in a giant congenital nevus. The retrospective comparison of our data reveals that in the evaluation of cutaneous malignant melanoma prognosis clinical parameters, as well as morphological ones, reprezented by Clark’s levels of invasion, Breslow’s thickness, tumour infiltrating lymphocytes, ulceration and vascular invasion, should be considered.

Doinita Radulescu

2006-10-01

328

Lack of GNAQ and GNA11 Germ-Line Mutations in Familial Melanoma Pedigrees with Uveal Melanoma or Blue Nevi  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Approximately 10% of melanoma cases are familial, but only 25–40% of familial melanoma cases can be attributed to germ-line mutations in the CDKN2A – the most significant high-risk melanoma susceptibility locus identified to date. The pathogenic mutation(s) in most of the remaining familial melanoma pedigrees have not yet been identified. The most common mutations in nevi and sporadic melanoma are found in BRAF and NRAS, both of which result in constitutive activation of the MAPK pathway....

Hawkes, Jason E.; Campbell, Jennifer; Garvin, Daniel; Cannon-albright, Lisa; Cassidy, Pamela; Leachman, Sancy A.

2013-01-01

329

Possibilidade de associação de melanoma e acromegalia Possibility of an association between melanoma and acromegaly  

Directory of Open Access Journals (Sweden)

Full Text Available Neoplasias como câncer de próstata, mama e cólon estão relacionadas à acromegalia. Raras vezes foi mencionada a associação com melanoma. Descreve-se caso de paciente com acromegalia no qual foi identificada lesão melanocítica suspeita, com posterior confirmação de melanoma. A excisão cirúrgica da lesão levou à cura da neoplasia. Chama-se a atenção para a necessidade de exame cuidadoso da pele de pacientes com acromegalia.Neoplasias such as prostate, breast, and colon cancer are commonly associated with acromegaly. However, the association of the latter with melanoma has been rarely mentioned. We describe the case of a patient with acromegaly in whom a suspicious melanocytic lesion was detected, and later confirmed to be melanoma by means of biopsy. Surgical excision of the lesion led to the cure of the neoplasia. More attention should be drawn to the need for careful skin examination of patients with acromegaly.

Carolina Garcia Soares Leães

2008-08-01

330

Pathogenesis, diagnosis and management of primary melanoma of the colon  

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Full Text Available Abstract Background Melanomas within the alimentary tract are usually metastatic in origin. On the other hand, primary melanomas of the gastrointestinal tract are relatively uncommon. There are several published reports of melanomas occurring in the esophagus, stomach, small bowel, and anorectum. The occurrence of primary melanoma of the colon has, however, only been rarely reported. The optimum modus operandi for the management of primary colonic melanoma remains nebulous due to the limited number of reports in literature. Methods A comprehensive search of Medline, Cochrane and Highwire was performed using the following keywords: 'melanoma', 'malignant melanoma', 'primary melanoma', 'colon', 'gastrointestinal tract', 'alimentary tract', 'digestive tract', and 'large bowel'. All patients with primary melanoma localized to the colon were included in the review. Patients with metastatic melanomas to the gastrointestinal (GI tract and primary melanomas localized to the GI tract in anatomic locations other than colon were excluded. Results There have been only 12 reported cases of primary melanoma of the colon to date. The average age of patients on presentation was 60.4 years without any significant gender predilection. Right colon (33% and cecum (33% were the most common sites for the occurrence of primary colonic melanoma while abdominal pain (58% and weight loss (50% were the most common presenting complaints. Colonoscopy is the most reliable diagnostic investigation and offers the additional advantage of obtaining tissue for diagnosis. S-100 and HMB-45 are highly sensitive and specific for the diagnosis of this malignancy. For primary colonic melanomas that have not metastasized to any distant parts of the body, surgical resection with wide margins appears to be the treatment of choice. Although the management was individualized in every case, most of the authors preferred traditional hemicolectomy as the favored surgical approach. Chemotherapeutic agents including interferons, cytokines, biological agents and radiation therapy for brain metastases have been reported as adjuvant and palliative options while considering malignant melanomas in general. The average recurrence-free interval was 2.59 years. Nine of the 12 reports documented follow-up in their patients. Two of these 9 (22.2% patients died. Conclusions Primary melanoma of the colon is a rare clinical entity. Whenever a seemingly primary melanoma is detected in an atypical location such as the colon, it is prudent to conduct a thorough clinical investigation to consider the possibility of metastatic disease. Further studies are needed to document the long term follow-up, survival advantage and safety of the management approaches employed in patients with primary colonic melanoma. Based on current data, surgical resection appears to be appropriate management for primary colonic melanomas; unless the disease has metastasized to distant sites where surgery may have a limited palliative role.

Imam Ayesha

2011-02-01

331

UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Ultraviolet (UV) irradiation from the sun has been epidemiologically and mechanistically linked to skin cancer, a spectrum of diseases of rising incidence in many human populations. Both non-melanoma and melanoma skin cancers are associated with sunlight exposure. In this review, we discuss the UV wavelength-dependent formation of the major UV-induced DNA damage products, their repair and mutagenicity and their potential involvement in sunlight-associated skin cancers. We emphasize the major ...

Pfeifer, Gerd P.; Besaratinia, Ahmad

2012-01-01

332

Melanoma Surveillance in the US: Melanoma, Ultraviolet Radiation, and Socioeconomic Status  

Centers for Disease Control (CDC) Podcasts

This podcast accompanies the publication of a series of articles on melanoma surveillance in the United States, available in the November supplement edition of the Journal of the American Academy of Dermatology. Chris Johnson, from the Cancer Data Registry of Idaho, discusses analyses examining the relationship between melanoma and two variables at the county level, ultraviolet radiation and socioeconomic status.  Created: 10/19/2011 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 10/19/2011.

2011-10-19

333

Melanoma de coroides en melanosis óculi / Choroidal melanoma in ocular melanosis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Casos clínicos: Se presentan cuatro casos de pacientes con signos clínicos de melanosis óculi. En todos se diagnosticó melanoma de coroides. Tres acudieron con disminución de visión en ojo afecto y fueron enucleados por presentar tumores grandes y activos. En el cuarto caso el melanoma fue descubier [...] to en una revisión rutinaria y se pudo aplicar un tratamiento conservador con braquiterapia con I125. Discusión: La melanosis óculi está infravalorada como factor de riesgo para melanoma y glaucoma. Es necesaria una revisión oftalmológica cada 6 ó 12 meses para la detección precoz de enfermedades de alto riesgo en estos pacientes. Abstract in english Cases: We present four cases of ocular melanosis. Choroidal melanoma was detected in all of them. Three eyes had decreased visual acuity and were enucleated because of their large, active tumours. In the fourth case the melanoma was detected in a routine examination and we were able to apply a prese [...] rving treatment with I125 brachytherapy. Discussion: Melanosis oculi is often underestimated as a risk factor for uveal melanoma and glaucoma. Ophthalmic surveillance, every 6 or 12 months is important, in patients with ocular melanocytosis for early detection of high risk diseases.

C, López Caballero; MA, Saornil Álvarez; G, Blanco Mateos; JM, Frutos Baraja; F, López Lara; C, González Sansegundo.

334

Melanoma de coroides en melanosis óculi Choroidal melanoma in ocular melanosis  

Directory of Open Access Journals (Sweden)

Full Text Available Casos clínicos: Se presentan cuatro casos de pacientes con signos clínicos de melanosis óculi. En todos se diagnosticó melanoma de coroides. Tres acudieron con disminución de visión en ojo afecto y fueron enucleados por presentar tumores grandes y activos. En el cuarto caso el melanoma fue descubierto en una revisión rutinaria y se pudo aplicar un tratamiento conservador con braquiterapia con I125. Discusión: La melanosis óculi está infravalorada como factor de riesgo para melanoma y glaucoma. Es necesaria una revisión oftalmológica cada 6 ó 12 meses para la detección precoz de enfermedades de alto riesgo en estos pacientes.Cases: We present four cases of ocular melanosis. Choroidal melanoma was detected in all of them. Three eyes had decreased visual acuity and were enucleated because of their large, active tumours. In the fourth case the melanoma was detected in a routine examination and we were able to apply a preserving treatment with I125 brachytherapy. Discussion: Melanosis oculi is often underestimated as a risk factor for uveal melanoma and glaucoma. Ophthalmic surveillance, every 6 or 12 months is important, in patients with ocular melanocytosis for early detection of high risk diseases.

C López Caballero

2003-02-01

335

The risk of cutaneous melanoma in melanocytic nevi / Risco de melanoma cutâneo nos nevos melanocíticos  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os dados sobre risco de melanoma cutâneo nos nevos melanocíticos são ainda controversos. O estudo longitudinal prospectivo de 107 casos de melanoma cutâneo revelou que em 9/107 casos (8,4%) houve presunção de lesão precursora, porém em 1/107 caso (0,9%) houve comprovação histopatológica para nevo me [...] lanocítico. A informação vaga de presença de lesão precursora do melanoma cutâneo torna vulnerável sua vinculação com o tumor e implica em comprovação histopatológica. Abstract in english The data on melanoma associaed with melanocytic nevus are controversial. A longitudinal prospective study of 107 cases of cutaneous melanoma revealed that 9 (8.4%) cases were presumed to be linked to a precursor lesion, but only in 1 (0.9%) out of these cases the histopathological examination showed [...] an associated melanocytic nevus. The vague information of a preexisting lesion of cutaneous melanoma is not sufficient to consider it a tumour precursor and it requires histopathological evidence to confirm the diagnosis.

Nurimar Conceição, Fernandes.

336

Melanoma involved in specific uptake of chlorpromazine (10B carrier) into melanoma cells  

International Nuclear Information System (INIS)

Interrelationship between melanosome and uptake of chlorpromazine (CPZ) into various melanoma cells (B16M-line, W line) having different capacity to produce melanosome and into macrophages feeding various amounts of melanosome was studied. The uptake of CPZ into melanoma cells was well correlated with the capacity to produce melanosome. The uptake of CPZ into macrophages containing melanosome increased according to feeding time and the concentration of melanosome. However, there was not a difference between the uptake of CPZ into macrophages containing latex particles and that into control cells. This fact clarified that promotion of the uptake of CPZ into macrophages containing melanosome depended on specific nature of intracellular melanosome. Therefore, specific uptake of CPZ into melanoma cells was thought to be determined initially by intracellular melanosome. These facts suggested that molecular hybrid of 10B and CPZ such as 10B12-CPZ was effective to melanotic melanoma and was ineffective to amelanotic melanoma. It will be possible to accumulate molecular hybrid of 10B and BPZ in tumors by feeding melanosome and perform thermal neutron capture treatment, if tumors excepting melanoma posses the capacity to feed melanosome. (Tsunoda, M.)

337

Amuvatinib has cytotoxic effects against NRAS-mutant melanoma but not BRAF-mutant melanoma.  

Science.gov (United States)

Effective targeted therapy strategies are still lacking for the 15-20% of melanoma patients whose melanomas are driven by oncogenic NRAS. Here, we report on the NRAS-specific behavior of amuvatinib, a kinase inhibitor with activity against c-KIT, Axl, PDGFR?, and Rad51. An analysis of BRAF-mutant and NRAS-mutant melanoma cell lines showed the NRAS-mutant cohort to be enriched for targets of amuvatinib, including Axl, c-KIT, and the Axl ligand Gas6. Increasing concentrations of amuvatinib selectively inhibited the growth of NRAS-mutant, but not BRAF-mutant melanoma cell lines, an effect associated with induction of S-phase and G2/M-phase cell cycle arrest and induction of apoptosis. Mechanistically, amuvatinib was noted to either inhibit Axl, AKT, and MAPK signaling or Axl and AKT signaling and to induce a DNA damage response. In three-dimensional cell culture experiments, amuvatinib was cytotoxic against NRAS-mutant melanoma cell lines. Thus, we show for the first time that amuvatinib has proapoptotic activity against melanoma cell lines, with selectivity observed for those harboring oncogenic NRAS. PMID:24950457

Fedorenko, Inna V; Fang, Bin; Koomen, John M; Gibney, Geoffrey T; Smalley, Keiran S M

2014-10-01

338

Cartilaginous melanoma: case report and review of the literature Melanoma cartilagíneo: caso clínico e revisão da literatura  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant melanoma can present a variety of histopathological patterns. Cartilaginous change in the absence of osteogenic differentiation is extremely rare in malignant melanoma, being among the least frequent of the wide range of melanoma histologic patterns. We report a case of a 47-year-old woman with a subungual nodule on her right great toe for many years. Histopathological examination of the lesion led to a diagnosis of malignant melanoma with cartilaginous differentiation devoid of concomitant osseous areas. It would appear that this unusual form of melanoma has a predilection for acral location, particularly the subungual region. Malignant melanoma with chondroid stroma should therefore be considered in the differential diagnosis of cartilaginous lesions of the toes and fingers. Careful examination of the overlying epidermis and identification of an in situ component of melanoma may be necessary in order to establish the correct diagnosis.O melanoma maligno pode apresentar uma grande variedade de padrões histopatológicos. A presença de diferenciação cartilagínea, na ausência de diferenciação osteogénica, é extremamente rara no melanoma maligno. O melanoma cartilagíneo está entre os padrões histológicos menos frequentes. Relatamos um caso de uma doente do sexo feminino de 47 anos de idade com um nódulo subungueal no 1º dedo do pé direito com muitos anos de evolução. O exame histopatológico da lesão revelou melanoma cartilagíneo, sem áreas de diferenciação osteogénica. Esta variante de melanoma parece ter predileção pela extremidades, sobretudo pela região subungueal. Assim, o melanoma maligno com diferenciação condróide, deve ser tido em consideração no diagnóstico diferencial de lesões acrais cartilagíneas. A observação cuidadosa da epiderme e a identificação de um componente do melanoma in situ podem ser necessários para estabelecer um diagnóstico correto.

Parente Joana Devesa

2013-06-01

339

Cartilaginous melanoma: case report and review of the literature / Melanoma cartilagineo: caso clinico e revisao da literatura  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese O melanoma maligno pode apresentar uma grande variedade de padrões histopatológicos. A presença de diferenciação cartilagínea, na ausência de diferenciação osteogénica, é extremamente rara no melanoma maligno. O melanoma cartilagíneo está entre os padrões histológicos menos frequentes. Relatamos um [...] caso de uma doente do sexo feminino de 47 anos de idade com um nódulo subungueal no 1º dedo do pé direito com muitos anos de evolução. O exame histopatológico da lesão revelou melanoma cartilagíneo, sem áreas de diferenciação osteogénica. Esta variante de melanoma parece ter predileção pela extremidades, sobretudo pela região subungueal. Assim, o melanoma maligno com diferenciação condróide, deve ser tido em consideração no diagnóstico diferencial de lesões acrais cartilagíneas. A observação cuidadosa da epiderme e a identificação de um componente do melanoma in situ podem ser necessários para estabelecer um diagnóstico correto. Abstract in english Malignant melanoma can present a variety of histopathological patterns. Cartilaginous change in the absence of osteogenic differentiation is extremely rare in malignant melanoma, being among the least frequent of the wide range of melanoma histologic patterns. We report a case of a 47-year-old woman [...] with a subungual nodule on her right great toe for many years. Histopathological examination of the lesion led to a diagnosis of malignant melanoma with cartilaginous differentiation devoid of concomitant osseous areas. It would appear that this unusual form of melanoma has a predilection for acral location, particularly the subungual region. Malignant melanoma with chondroid stroma should therefore be considered in the differential diagnosis of cartilaginous lesions of the toes and fingers. Careful examination of the overlying epidermis and identification of an in situ component of melanoma may be necessary in order to establish the correct diagnosis.

Parente, Joana Devesa; Jose Manuel Pereira da Silva, Labareda; Elvira Augusta Felgueira Leonardo Fernandes, Bartolo; Maria Fernanda Sachse Pinto Fonseca, Santos; Esmeralda Maria Seco do, Vale.

2013-06-01

340

Nodular malignant melanoma - Secondary to carcinoma rectum  

Directory of Open Access Journals (Sweden)

Full Text Available A 45-year female presented with a sudden eruption of multiple brownish black nodular lesions since 5 months over the face, trunk and extremities which were clinically diagnosed as a case of nodular malignant melanoma. Histopathologically, they revealed the secondaries from carcinoma rectum.

Chopra Adarsh

1997-01-01

 
 
 
 
341

Gamma knife therapy for intraocular melanomas  

International Nuclear Information System (INIS)

Gamma knife radiosurgery developed by Lars Leksell for the treatment of brain tumors is useful for the treatment of uveal melanomas due to its unique physical features. It allows the delivery of a high single dose with minimum involvement of the surrounding tissue. Encouraged by first positive results by Chinela, Zambrano and Bunge we adopted the procedure for the treatment of uveal melanomas. A multi centric trial in accordance with gamma knife procedure is performed in 4 steps: 1. Fixation of the globe with a retrobulbar anaesthetic block. 2. Stereotactic location of the tumor by CT. 3. Calculation of the isodoses. 4. Radiosurgical procedure. Between June 1992 and February 1993 we treated 6 uveal melanomas with the Leksell gamma knife together with the Department of Neurosurgery and the Institute of Radiotherapy. In 5 out of 6 cases gamma knife therapy could stop further tumor growth. In one case of a juxtapapillary melanoma a reduction of tumor height from 8 to 4 mm could be achieved: early side effects like serous retinal detachment resolving spontaneously after 4 months and hemorrhage at the base of the tumor were remarkable in this patient. According to our first encouraging results treatment with the Leksell Gamma Knife seems to be an alternative therapeutic modality in larger tumors or those located at the posterior pole but definite conclusions about the efficiency of this new therapeutic procedure can only be drawn once. A larger number of patients will have been observed after a longer follow up period. (author)

342

Radiotherapy in the cerebral metastatic malignant melanoma  

International Nuclear Information System (INIS)

A retrospective analysis of 21 patients with cerebral metastasis from malignant melanoma was done. Two groups of patients were defined: patients receiving cranial radiation therapy with total dose higher than 20 Gy with or without other Kinds of therapy and patients not irradiated. (M.A.C.)

343

Inflammatory bowel disease raises risk of melanoma  

Science.gov (United States)

Patients with inflammatory bowel disease (IBD) are at higher risk of melanoma, a form of skin cancer, report researchers at Mayo Clinic. Researchers found that IBD is associated with a 37 percent greater risk for the disease. The findings were presented at the Digestive Disease Week 2013 conference in Orlando, Fla.

344

Testing Adjuvant Ipilimumab in Advanced Melanoma  

Science.gov (United States)

In this clinical trial, patients with stage III or stage IV melanoma that has been completely resected will be randomly assigned to receive adjuvant (post-surgical) treatment with either ipilimumab or high-dose interferon alfa-2b, the current standard of care.

345

Choroidal melanoma clinically simulating a retinal angioma  

International Nuclear Information System (INIS)

An amelanotic fundus lesion in a 35-year-old man was associated with a dilated retinal vessel, thus suggesting the diagnosis of retinal angioma. Fluorescein angiography and B-scan ultrasonography were not diagnostic, but a radioactive phosphorus uptake test suggested the lesion was malignant. The enucleated globe showed a malignant choroidal melanoma drained by a large retinal vein

346

Anatomoclinical aspects of conjunctival malignant metastatic melanoma.  

Science.gov (United States)

Conjunctival malignant melanoma is a rare tumor with a high risk of local recurrence, lymph node and systemic metastases. The aim of this study was to correlate tumor thickness, tumor ulceration, high mitotic rate, epithelioid cells with the presence of metastases and death from conjunctival malignant melanoma. We report the case of a 33-year-old patient who presented with a left eyelid ptosis associated with an eyelid prominence, foreign body sensation in the eye, and bloody discharge, symptoms occurring about one month earlier. Ophthalmologic examination revealed in eyelid conjunctiva two vegetant and ulcerative tumors of 8÷6 mm and 3÷3 mm. The two tumors were surgically removed with safety margins. The diagnosis of amelanotic malignant melanoma of the conjunctiva with brain metastasis was made by routine morphological methods and immunohistochemical reactions (HMB45, vimentin, S100 protein). Systemic metastases (skin, brain, lung, liver, kidney, peritoneal) and peripancreatic lymph node metastases were detected at 1.9 years after the diagnosis of conjunctival malignant melanoma. The patient died three months after the surgical excision of brain metastasis. Early diagnosis is essential to prevent tumor recurrence, ocular invasion, systemic and lymph node metastases, and preserving visual function. PMID:25329123

Costea, Claudia Florida; Anghel, Kreolla; Dimitriu, Gabriela; Dumitrescu, Gabriela Floren?a; Faiyad, Ziyad; Dumitrescu, Ana Maria; Sava, Anca

2014-01-01

347

Primary Malignant Melanoma of the Nasal Cavity.  

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Full Text Available Malignant melanoma is a highly lethal melanocytic neoplasm, usually affecting theskin. Primary malignant melanoma of the nasal cavity is rarely seen. Clinically, mostpatients display initial nonspecific symptoms of unilateral nasal obstruction or epistaxis.The prognosis is generally poor, with a mean survival time of 3.5 years. Extensive localinvasion and distant metastasis to other organs may occur. The usual treatment of choice isradical excision. Radiotherapy and chemotherapy appear to have little effect. We report afatal case of intranasal cavity malignant melanoma in which the patient initially presentedwith blood-tinged sputum, productive cough, and intermittent fever. Preoperative hepaticmetastasis was found. Palliative surgery was performed to excise the nasal cavity tumor.Then, 6 courses of chemotherapy were further administered. Unfortunately, regional cervicalnodal involvement and pancreatic head metastases occurred 1.5 years after the diagnosis.The patient's condition rapidly deteriorated, followed by death. We have chosen to discussthis aggressive condition because of its rarity and also to emphasize the importance of itsearly detection through vigilant attention to nonspecific nasal symptoms. A review of theliterature concerning intranasal malignant melanoma is presented. We further discuss itspossible etiology, site of origin, incidence, clinical presentations, principles of management,and outcome.

Chin-Yew Lin

2003-11-01

348

Choroidal melanoma clinically simulating a retinal angioma  

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An amelanotic fundus lesion in a 35-year-old man was associated with a dilated retinal vessel, thus suggesting the diagnosis of retinal angioma. Fluorescein angiography and B-scan ultrasonography were not diagnostic, but a radioactive phosphorus uptake test suggested the lesion was malignant. The enucleated globe showed a malignant choroidal melanoma drained by a large retinal vein.

Shields, J.A.; Joffe, L.; Guibor, P.

1978-01-01

349

Metastatic Malignant Melanoma Mimicking Benign Breast Cysts  

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Benign cysts are one of the most common mass-occupying lesions of the breast and are often investigated with triple diagnostic trial (clinical examination, radiology, and cytology). Malignant melanoma is one of medicine's imitators, and metastatic disease can mimic cysts. Thorough investigation of any breast mass is essential to clarify its nature.

Marius Lund-Iversen; Hiep Phuc Dong; Amp Skjold, Olav Inge H.; Aasmund Berner

2011-01-01

350

How melanoma cells inactivate NK cells  

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NK cells are the most potent effectors against different tumors in vitro. However, their efficacy in vivo is compromised by suppressive signals delivered by tumor or tumor-associated cells. This study unravels the molecular mechanisms by which melanomas disarm NK cells and offers clues to revert such inhibitory effect. PMID:23162776

Pietra, Gabriella; Vitale, Massimo; Moretta, Lorenzo; Mingari, Maria Cristina

2012-01-01

351

Adoptive Cell Therapy for Patients with Melanoma  

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Full Text Available Adoptive cell therapy can be an effective treatment for some patients with advanced cancer. This report summarizes clinical trial results from the Surgery Branch, NCI, investigating tumor infiltrating lymphocytes (TIL and gene engineered peripheral blood T cells for the therapy of patients with melanoma and other solid tumors.

Mark E. Dudley

2011-01-01

352

Metastatic malignant ovarian melanoma: A case report  

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Full Text Available Background. Malignant melanomas of the female reproductive system are rare. These are biologically highly aggressive tumors with poor prognosis. Preoperative establishment of the diagnosis is practically impossible. Therapeutic approach and treatment of patients with metastatic ovarian melanoma are highly dependent on precise histological analysis. Case report. A woman aged 48 was admitted to the clinic for occasional pains in the lower abdomen and suspected myomatous changes of the uterus. The patient underwent surgery for melanoma on her right arm five years ago. Classic hysterectomy with bilateral adnexectomy with infracolic omentectomy and selective iliac lymphadenectomy were performed. Macroscopic examination revealed an oval tumefaction on the left ovary sized 12.5 x 10 x 3.5 cm of solid structure. Tumor tissue was yellowish-brown colored, of solid structure and mostly localized subcortically with central edema. Microscopic examination showed positive reaction for HMB-45, anti-Melan-A and S-100 protein, but negative immunoreactivity for estrogen and progesterone receptors. Malignant disease caused death after a 4-year follow-up period following gynecological operation. Conclusion. The previous diagnosis of skin melanoma is also indicative of metastatic ovarian tumor, while immunohistochemical analyses confirmed the histopathological diagnosis.

Berisavac Milica

2013-01-01

353

Cutaneous malignant melanoma: update on diagnostic and prognostic biomarkers.  

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The incidence of cutaneous malignant melanoma has rapidly increased in recent years in all parts of the world, and melanoma is a leading cause of cancer death. As even relatively small melanomas may have metastatic potential, accurate assessment of progression is critical. Although diagnosis of cutaneous malignant melanoma is usually based on histopathologic criteria, these criteria may at times be inadequate in differentiating melanoma from certain types of benign nevi. As for prognosis, tumor (Breslow) thickness, mitotic rate, and ulceration have been considered the most important prognostic indicators among histopathologic criteria. However, there are cases of thin primary melanomas that have ultimately developed metastases despite complete excision. Given this, an accurate assessment of melanoma progression is critical, and development of molecular biomarkers that identify high-risk melanoma in its early phase is urgently needed. Large-scale genomic profiling has identified considerable heterogeneity in melanoma and suggests subgrouping of tumors by patterns of gene expression and mutation will ultimately be essential to accurate staging. This subgrouping in turn may allow for more targeted therapy. In this review, we aim to provide an update on the most promising new biomarkers that may help in the identification and prognostication of melanoma. PMID:24803061

Abbas, Ossama; Miller, Daniel D; Bhawan, Jag

2014-05-01

354

Canine malignant melanoma alpha-3 integrin binding peptides  

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There is a need to develop novel targeted imaging and therapeutic agents that can aid in early diagnosis, detection of metastasis and treatment of melanoma. Alpha-3 integrin is overexpressed in 82% of metastatic melanomas in humans and may be a potential target for peptide ligands carrying therapeutic agents. Five melanoma cell lines were generated from canine primary oral and metastatic canine tumors, grown in mice, and validated with melanoma markers Melan A, S-100, Micropthalmia transcription factor (MITF), Tyrosinase, and MART-1. The melanoma cell lines were tested for binding affinity to previously published alpha-3 integrin-binding peptides containing the cdGXGXXc motif. Fluorescent conjugates of the alpha-3 integrin binding OA02 peptide were used to quantify receptor affinity in the cell lines, a specimen of canine primary oral melanoma, and melanoma xenografts. Alpha-3 integrin was expressed by all 5 canine melanoma cell lines. Four of the 5 lines as well as the primary canine tumor showed affinity to alpha-3 integrin binding peptides with the cdGXGXXc motif. Optical imaging of canine melanoma xenografts in nude mice indicates rapid, strong uptake of the optical tracer in the tumor with an average persistence of approximately 48 hours. Ex vivo images showed high tumor-to-background ratio, with tumor signals more than twice that of the kidney and other vital organs. We propose that integrin alpha-3 integrin binding ligands could potentially become useful probes for imaging and delivery of cytotoxic agents for the treatment of melanoma. PMID:21722969

Aina, Olulanu H.; Maeda, Yoshiko; Harrison, Matthew; Zwingenberger, Allison L.; Walker, Naomi J.; Lam, Kit S.; Kent, Michael S.

2014-01-01

355

Dermoscopic features of thin melanomas: a comparative study of melanoma in situ and invasive melanomas smaller than or equal to 1mm / Caracteristicas dermatoscopicas de melanomas finos: estudo comparativo entre melanomas in situ e melanomas invasivos menores ou iguais a 1mm  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese FUNDAMENTOS: A dermatoscopia propicia o diagnóstico mais precoce do melanoma. A estimativa préoperatória da espessura de Breslow através da dermatoscopia poderia ser útil no planejamento da conduta cirúrgica e seleção dos pacientes para a biópsia de linfonodo sentinela. OBJETIVOS: Este estudo [...] objetiva descrever as características dermatoscópicas encontradas em melanomas finos e comparar melanomas in situ com melanomas invasivos menores ou iguais a 1 mm. MÉTODOS: Trata-se de estudo observacional, retrospectivo, no qual avaliouse o registro fotográfico da dermatoscopia de 41 melanomas finos. Três observadores avaliaram em conjunto 14 critérios dermatoscópicos. RESULTADOS: Dentre os melanomas finos, os critérios mais encontrados foram: presença de assimetria nos dois eixos em 95% (39 casos), 3 ou mais cores em 80,4% (33 casos), pontos ou glóbulos atípicos em 58,5% (24 casos) e rede atípica ou estrias radiadas em 53,6% (22 casos). O grupo dos melanomas invasivos apresentou com maior frequência e significância estatística (p Abstract in english BACKGROUND: Dermoscopy allows the early detection of melanomas. The preoperative determination of Breslow index by dermoscopy could be useful in planning the surgical approach and in selecting patients for sentinel lymph node biopsy. OBJECTIVES: This study aims at describing the dermoscopic fe [...] atures of thin melanomas and comparing melanomas in situ with invasive melanomas less than or equal to 1 mm thick. METHODS: This was an observational retrospective study in which the dermoscopy photographs of 41 thin melanomas were evaluated. Three observers evaluated together 14 dermoscopic criteria. RESULTS: Among thin melanomas, the most frequent criteria were presence of asymmetry in two axes in 95% of cases (39 cases), 3 or more colors in 80.4% of cases (33 cases), atypical dots or globules in 58.5% of cases (24 cases) and atypical network or streaks in 53.6% of cases (22 cases). The group of invasive melanomas presented with a higher frequency and statistical significance (p

Vanessa Priscilla Martins da, Silva; Juliana Kida, Ikino; Mariana Mazzochi, Sens; Daniel Holthausen, Nunes; Gabriella, Di Giunta.

2013-10-01

356

Dermoscopic features of thin melanomas: a comparative study of melanoma in situ and invasive melanomas smaller than or equal to 1mm / Caracteristicas dermatoscopicas de melanomas finos: estudo comparativo entre melanomas in situ e melanomas invasivos menores ou iguais a 1mm  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese FUNDAMENTOS: A dermatoscopia propicia o diagnóstico mais precoce do melanoma. A estimativa préoperatória da espessura de Breslow através da dermatoscopia poderia ser útil no planejamento da conduta cirúrgica e seleção dos pacientes para a biópsia de linfonodo sentinela. OBJETIVOS: Este estudo [...] objetiva descrever as características dermatoscópicas encontradas em melanomas finos e comparar melanomas in situ com melanomas invasivos menores ou iguais a 1 mm. MÉTODOS: Trata-se de estudo observacional, retrospectivo, no qual avaliouse o registro fotográfico da dermatoscopia de 41 melanomas finos. Três observadores avaliaram em conjunto 14 critérios dermatoscópicos. RESULTADOS: Dentre os melanomas finos, os critérios mais encontrados foram: presença de assimetria nos dois eixos em 95% (39 casos), 3 ou mais cores em 80,4% (33 casos), pontos ou glóbulos atípicos em 58,5% (24 casos) e rede atípica ou estrias radiadas em 53,6% (22 casos). O grupo dos melanomas invasivos apresentou com maior frequência e significância estatística (p Abstract in english BACKGROUND: Dermoscopy allows the early detection of melanomas. The preoperative determination of Breslow index by dermoscopy could be useful in planning the surgical approach and in selecting patients for sentinel lymph node biopsy. OBJECTIVES: This study aims at describing the dermoscopic fe [...] atures of thin melanomas and comparing melanomas in situ with invasive melanomas less than or equal to 1 mm thick. METHODS: This was an observational retrospective study in which the dermoscopy photographs of 41 thin melanomas were evaluated. Three observers evaluated together 14 dermoscopic criteria. RESULTS: Among thin melanomas, the most frequent criteria were presence of asymmetry in two axes in 95% of cases (39 cases), 3 or more colors in 80.4% of cases (33 cases), atypical dots or globules in 58.5% of cases (24 cases) and atypical network or streaks in 53.6% of cases (22 cases). The group of invasive melanomas presented with a higher frequency and statistical significance (p

Vanessa Priscilla Martins da, Silva; Juliana Kida, Ikino; Mariana Mazzochi, Sens; Daniel Holthausen, Nunes; Gabriella, Di Giunta.

357

Mechanisms of chromosomal instability in melanoma.  

Science.gov (United States)

A systems biology approach was applied to investigate the mechanisms of chromosomal instability in melanoma cell lines. Chromosomal instability was quantified using array comparative genomic hybridization to identify somatic copy number alterations (deletions and duplications). Primary human melanocytes displayed an average of 8.5 alterations per cell primarily representing known polymorphisms. Melanoma cell lines displayed 25 to 131 alterations per cell, with an average of 68, indicative of chromosomal instability. Copy number alterations included approximately equal numbers of deletions and duplications with greater numbers of hemizygous (-1,+1) alterations than homozygous (-2,+2). Melanoma oncogenes, such as BRAF and MITF, and tumor suppressor genes, such as CDKN2A/B and PTEN, were included in these alterations. Duplications and deletions were functional as there were significant correlations between DNA copy number and mRNA expression for these genes. Spectral karyotype analysis of three lines confirmed extensive chromosomal instability with polyploidy, aneuploidy, deletions, duplications, and chromosome rearrangements. Bioinformatic analysis identified a signature of gene expression that was correlated with chromosomal instability but this signature provided no clues to the mechanisms of instability. The signature failed to generate a significant (P?=?0.105) prediction of melanoma progression in a separate dataset. Chromosomal instability was not correlated with elements of DNA damage response (DDR) such as radiosensitivity, nucleotide excision repair, expression of the DDR biomarkers ?H2AX and P-CHEK2, nor G1 or G2 checkpoint function. Chromosomal instability in melanoma cell lines appears to influence gene function but it is not simply explained by alterations in the system of DDR. PMID:24616037

Kaufmann, William K; Carson, Craig C; Omolo, Bernard; Filgo, Adam J; Sambade, Maria J; Simpson, Dennis A; Shields, Janiel M; Ibrahim, Joseph G; Thomas, Nancy E

2014-07-01

358

Melanoma acrolentiginoso: um desafio ao diagnóstico precoce Acral lentiginous melanoma: a challenge for early diagnosis  

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Full Text Available FUNDAMENTOS: As características do melanoma acrolentiginoso (MAL diagnosticado no Brasil são pouco estudadas. OBJETIVOS: Avaliar as características do MAL diagnosticado na Unidade de Melanoma da Santa Casa de São Paulo - UMSC, comparando essa manifestação com outros subtipos e verificar se as possíveis diferenças entre eles teriam importância na determinação do diagnóstico, tratamento e prognóstico. MÉTODO: A Casuística da UMSC foi subdividida em dois grupos, um de melanoma acrolentiginoso (MAL e outro de melanoma não acrolentiginoso (NAL, que foram comparados quanto a sexo, cor, idade, espessura e nível de invasão da lesão primária, estadiamento, tempo decorrido entre a percepção do tumor e o atendimento pelo médico. RESULTADOS: A casuística correspondente ao MAL mostrou freqüência significativa de pacientes não brancos, com faixa etária mais elevada, com a lesão primária em média, mais espessa e ulcerada. Não ocorreram diferenças significativas quanto ao sexo e estadiamento, bem como com relação ao tempo decorrido entre perceber a neoplasia e procurar o médico. CONCLUSÕES: O MAL diagnosticado na UMSC ocorre, principalmente, em pacientes que normalmente não são alertados para câncer da pele (não brancos e pertencem a uma faixa etária mais elevada (portanto, do ponto de vista teórico, poderiam estar menos atentos ao início da doença. A maioria apresentou lesão espessa e ulcerada, conseqüentemente de maior risco para metástases. Essa forma de câncer é desconhecida do público em geral e mesmo por boa parcela da classe médica.BACKGROUND: The characteristics of acral lentiginous melanoma diagnosed in Brazil have been subject to few studies. OBJECTIVES: To evaluate the characteristics of acral lentiginous melanoma diagnosed at the Melanoma Unit of Santa Casa Hospital of Sao Paulo, to compare them with the other melanoma subtypes and to verify whether the possible differences between them are important in the determination of the diagnosis, treatment and prognosis. METHOD: Patients were divided into acral lentiginous melanoma and non-acral lentiginous melanoma groups and compared in reference to sex, color, age, depth and level of invasion of the primary lesion, stage, time between perceiving the tumor and seeking medical assistance. RESULTS: The cases of acral lentiginous melanoma were significantly more frequent among non-whites and the elderly, with the primary lesion, on average deeper and ulcerated, without significant differences in the sex, stage or the time elapsed between noticing the neoplasia and seeking the physician. CONCLUSIONS: Acral lentiginous melanoma diagnosed at the Melanoma Unit of Santa Casa Hospital of Sao Paulo, occurred mainly: in patients: who had not been advised about skin cancer (non-whites and patients who are elderly and therefore, theoretically, could be less liable to notice the onset of the disease. The majority also presented deeper and ulcerated lesions and consequently with a higher risk of metastasis. This kind of cancer is unknown to the public in general and even to a large number of physicians.

Marcus Maia

2003-10-01

359

Melanoma cutâneo: estudo prospectivo de 65 casos Cutaneous melanoma: prospective study of 65 cases  

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Full Text Available FUNDAMENTOS: A incidência e a mortalidade por melanoma cutâneo vêm aumentando em todo o mundo. Os registros brasileiros de bases populacionais não refletem precisamente a real dimensão do problema. OBJETIVOS: Estudo prospectivo de 65 casos de melanoma cutâneo observados no Hospital Universitário Clementino Fraga Filho no período de 1993 a 2003. MÉTODOS: Foram analisadas as variáveis idade, sexo, cor, localização, tipos clínico-histológicos e estadiamento. RESULTADOS: 64,7% na faixa etária de 40 a 69 anos, distribuição etária homogênea entre o sexo masculino (49,2% e o sexo feminino (50,8%, predominância de brancos (83%, localização no tronco (35,3%, tipo clínico-histológico expansivo superficial (63%/30,7% e relação de significância entre tipo acral localizado no pé em não brancos. Segundo o American Joint Committee on Cancer, em 2002, 22 casos (33,8% no estádio IA, 14 (21,5% melanomas in situ e um caso indeterminado. CONCLUSÕES: O melanoma cutâneo primário na amostra estudada mostrou padrões semelhantes aos classicamente reconhecidos e maior freqüência do estádio IA e melanoma in situ.BACKGROUND: Incidence and mortality of cutaneous melanoma are increasing all over the world. The data base for the Brazilian population is still inadequate. OBJECTIVES: Prospective study of 65 cases seen at University Hospital Clementino Fraga Filho, from 1993 to 2003. METHODS: Patient's age, sex, ethnic group, anatomic site, clinical histological presentation and staging were analyzed. RESULTS: The case distribution was 64.7% aged 40 to 69 years, males (49.2% and females (50.8%, majority white (83.1%, most lesions in the trunk (35.3%, more frequently of the clinical histological superficial spreading type (63%/30.7% and significant relationship between foot acral type in non-whites. According to American Joint Committee on Cancer 2002 system, 22 cases (33.8% in stage IA, 14 (21.5% melanomas in situ, and one indeterminate case. CONCLUSIONS: Primary cutaneous melanoma in the present study has a similar pattern to other published series and higher frequency of stage IA and in situ melanomas.

Nurimar C. Fernandes

2005-02-01

360

HLA Associations in the Antitumor Response Against Malignant Melanoma  

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In this study we analyzed the human leukocyte antigen (HLA) pattern of North American Caucasian patients with metastatic melanoma as compared with the North American Caucasian (NAC) population. We also investigated whether the HLA type of melanoma patients had an effect on their tolerance and response to interleukin-2 (IL-2)-based therapy. Four hundred twelve serologic phenotypes of Caucasian melanoma patients referred to the National Cancer Institute, National Institutes of Health, from Febr...

Marincola, Francesco M.; Shamamian, Peter; Rivoltini, Licia; Salgaller, Michael; Cormier, Janice; Restifo, Nicholas P.; Simonis, Toni B.; Venzon, David; White, Donald E.; Parkinson, David R.

1995-01-01

 
 
 
 
361

A Cohort Study of Vitamin D Intake and Melanoma Risk  

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Data suggest that vitamin D intake may have chemopreventive efficacy against melanoma, but there have been no published epidemiologic studies examining the association between vitamin D intake and melanoma risk in a large prospective cohort. We examined whether dietary and supplemental vitamin D intake was associated with melanoma risk among 68,611 men and women who were participants of the Vitamins and Lifestyle cohort study. Participants reported dietary vitamin D intake over the past year ...

Asgari, Maryam M.; Maruti, Sonia S.; Kushi, Lawrence H.; White, Emily

2009-01-01

362

Linfonodo sentinela em melanoma de criança: relato de caso  

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Objetivo: apresentar um caso de melanoma cutâneo na infância, submetido à biópsia de linfonodo sentinela. Descrição: criança de 12 anos de idade, portadora da síndrome do nevo displásico, desenvolveu melanoma em dorso. A biópsia excisional revelou melanoma (Breslow = 1,5 mm), sendo submetida a tratamento cirúrgico da lesão, com ampliação de margem de 2cm e biópsia de linfonodo sentinela. O exame anatomopatológico não mostrou doença residual. O exame do linfonodo sentinela n?...

Oliveira Filho Renato Santos de; Paiva Geruza Rezende; Ferreira Lydia M.; Alves Marcos Chaves de Arruda; Santos Ivan Dunshee A.O.; Enokihara Milvia M.S.S.

2002-01-01

363

Treated Choroidal Melanoma with Late Metastases to the Contralateral Orbit  

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Full Text Available Choroidal melanoma is the commonest adult primary intraocular tumour,1 and usual sites of secondary spread are to liver, bone and lung. Although delayed recurrence of ipsilateral orbital melanoma is well documented, metastasis to the contralateral orbit is a rarely encountered phenomenon. We describe a case of metastatic spread to the contralateral orbit in a patient 12 years after proton beam radiotherapy of choroidal melanoma.

Sonia George

2009-01-01

364

Current Research and Development of Chemotherapeutic Agents for Melanoma  

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Cutaneous malignant melanoma is the most lethal form of skin cancer and an increasingly common disease worldwide. It remains one of the most treatment-refractory malignancies. The current treatment options for patients with metastatic melanoma are limited and in most cases non-curative. This review focuses on conventional chemotherapeutic drugs for melanoma treatment, by a single or combinational agent approach, but also summarizes some potential novel phytoagents discovered from dietary vege...

Kyaw Minn Hsan; Chun-Chieh Chen; Lie-Fen Shyur

2010-01-01

365

Palliative radiotherapy for malign melanoma: a case report  

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Full Text Available Malignant melanoma is a skin cancer with poor prognosis. Historically melanoma has been thought of as a relatively radioresistant tumour. Nowadays, radiation delivered according to hypofractionated schedule is the most used, although there are few data confirm that this schedule improves the therapeutic impact. We report a case, with stage IV malignant melanoma, whose tumoral bleeding was palliated successfully giving 20 Gy external radiotherapy in 5 fractionations.

Vuslat YÜRÜT-ÇALO?LU

2006-01-01

366

Melanoma: Prognostic and Predictive Factors in Interferon Immunotherapy  

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Melanoma is a malignant tumor of melanocytes and is the most severe form of skin cancer. The name melanoma originates from the Greek word ????? (melas), meaning black or dark, whereas the suffix ‘oma’ denotes swelling or tumor. René Laennec was a French physician who was the first to describe melanoma as a disease entity. After being presented in a lecture in 1804 for the Faculté de Médecine de Paris, it was published in 1806 as a bulletin.1 However, the first surge...

Bouwhuis, M. G.

2011-01-01

367

IL8 and Cathepsin B as Melanoma Serum Biomarkers  

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Melanoma accounts for only a small portion of skin cancer but it is associated with high mortality. Melanoma serum biomarkers that may aid early diagnosis or guide therapy are needed clinically. However, studies of serum biomarkers have often been hampered by the serum interference that causes false readouts in immunological tests. Here we show that, after using a special buffer to eliminate the serum interference, IL-8 and cathepsin B levels were significantly elevated in melanoma patients (...

Xiaowei Xu; Lynn Schuchter; David Speicher; Ting Fu; Suzanne McGettigan; Suresh Kumar; Shujing Liu; Hongtao Zhang

2011-01-01

368

Immunotoxins: A Promising Treatment Modality for Metastatic Melanoma?  

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The incidence of melanoma is rising in the Western population, and melanoma is the most aggressive form of skin cancer with a very poor prognosis once it has progressed to metastatic stages. Patients with stage IV melanoma (metastases to distant lymph nodes and other areas of the body) are treated with the chemotherapeutic drug dacarbazine (DTIC). However, fewer than 5% of the patients treated with DTIC sustain long-term complete responses; hence, DTIC is administered with palliative purposes...

Risberg, Karianne; Fodstad, Øystein; Andersson, Yvonne

2010-01-01

369

A rare case of intracranial metastatic amelanotic melanoma with cyst  

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A rare case of intracranial metastatic amelanotic melanoma with cyst is presented. The patient was a 51 year old woman with a malignant melanoma arising on her right chest. Two years after a wide excision, skin and brain metastasis occurred. Brain magnetic resonance images demonstrated a tumour with a cyst in the left occipital lobe. Because the tumour showed low intensity on T1 weighted images and high intensity on T2 weighted images, the metastatic melanoma was identified as an amelanotic m...

Ogawa, R.; Aoki, R.; Hyakusoku, H.

2003-01-01

370

Dabrafenib for treatment of BRAF-mutant melanoma  

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Radhika Kainthla,1 Kevin B Kim,2 Gerald S Falchook31Department of Internal Medicine, Baylor College of Medicine, 2Department of Melanoma Medical Oncology, 3Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: Melanoma has the highest mortality of all the skin cancer subtypes. Historically, chemotherapy and immunologic therapies have yielded only modest results in the treatment of metastatic melanoma. The discovery of p...

Kainthla R; Kb, Kim; Gs, Falchook

2013-01-01

371

Sunbed use, Sunscreen use, Childhood Sun Exposure, and Cutaneous Melanoma  

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Cancer registries established after World War II show that in most light?skinned populations, the incidence of malignant cutaneous melanoma (hereafter termed melanoma) has steadily increased. In the 1970s and 1980s, laboratory and epidemiological studies documented the possibility that solar radiation was the main environmental risk factor for most skin cancers, including melanoma, the basal cell carcinoma (BCC) and the squamous cell carcinoma (SCC).

Autier P.J.M.

2011-01-01

372

Enrichment of circulating melanoma cells (CMCs) using negative selection from patients with metastatic melanoma.  

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Circulating tumor cells have emerged as prognostic biomarkers in the treatment of metastatic cancers of epithelial origins viz., breast, colorectal and prostate. These tumors express Epithelial Cell Adhesion Molecule (EpCAM) on their cell surface which is used as an antigen for immunoaffinity capture. However, EpCAM capture technologies are of limited utility for non-epithelial cancers such as melanoma. We report a method to enrich Circulating Melanoma Cells (CMCs) that does not presuppose malignant cell characteristics. CMCs were enriched by centrifugation of blood samples from healthy (N = 10) and patient (N = 11) donors, followed by RBC lysis and immunomagnetic depletion of CD45-positive leukocytes in a specialized magnetic separator. CMCs were identified by immunocytochemistry using Melan-A or S100B as melanoma markers and enumerated using automated microscopy image analyses. Separation was optimized for maximum sensitivity and recovery of CMCs. Our results indicate large number of CMCs in Stage IV melanoma patients. Analysis of survival suggested a trend toward decreased survival with increased number of CMCs. Moreover, melanoma-associated miRs were found to be higher in CMC-enriched fractions in two patients when compared with the unseparated samples, validating this method as applicable for molecular analyses. Negative selection is a promising approach for isolation of CMCs and other EpCAM -negative CTCs, and is amenable to molecular analysis of CMCs. Further studies are required to validate its efficacy at capturing specific circulating cells for genomic analysis, and xenograft studies. PMID:24811334

Joshi, Powrnima; Jacobs, Barbara; Derakhshan, Adeeb; Moore, Lee R; Elson, Paul; Triozzi, Pierre L; Borden, Ernest; Zborowski, Maciej

2014-05-15

373

Clinical Characteristics of Cutaneous Melanoma and Second Primary Malignancies in a Dutch Hospital-Based Cohort of Cutaneous Melanoma Patients  

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Full Text Available The increasing number of living cutaneous melanoma patients and the increased risk of developing a second primary tumour incited us to analyse the clinical characteristics of cutaneous melanoma and define the frequency, site, and type of second primary cancers in cutaneous melanoma patients. We collected data on patients who visited the Department of Dermatology at the Radboud University Nijmegen Medical Centre and were newly diagnosed with cutaneous melanoma or metastasis of melanoma with unknown primary localization between 2002 and 2006. A total of 194 cases were included; eleven patients developed a subsequent melanoma, 24 had at least one basal cell carcinoma, three had at least one squamous cell carcinoma, and 21 patients had a second non-cutaneous primary malignancy. In conclusion, 48 patients developed a subsequent malignancy. As nonmelanoma skin cancer is the most frequent second malignancy, our results subscribe to the necessity of follow-up by a dermatologist.

Haike M. J. van der Velden

2009-01-01

374

Diagnotic Support System of Melanoma based on Morphological Features  

Science.gov (United States)

At present the diagnosis of melanoma is mainly performed based on the experience of each doctor. They need some objective measure for diagnosis of melanoma and nevus. But there are few researches on index for the diagnosis. This study deals with features of melanoma and nevus for computer diagnosis. First, we extracted the contour of lesions by image processing. One hundred five values of features were computed based on ABCD-rule. Discriminant analysis showed the accuracy of 96.0% (Specificity of 98.3% and the Sensitivity of 90.0%). The results obviously showed the difference between melanoma and nevus.

Tanaka, Toshiyuki; Yamada, Reina; Tanaka, Michiko; Shimizu, Kunio; Tanaka, Masaru

375

Malignant melanoma cure by selective thermal neutron capture therapy  

International Nuclear Information System (INIS)

Thermal neutrons are easily absorbed by the nonradioactive isotope 10B, resulting in the emission of alpha particles and lithium atoms, which release an energy of 2.33 MeV for up to a 14-?m-diam melanoma cell. Thus, if 10B can be selectively accumulated in melanoma, it can be destroyed without injury to the surrounding normal tissues by concentrating high linear energy transfer particles. The authors have synthesized seven melanoma-seeking 10B compounds, two of which, 10B12-chlorpromazine(10B12-CPZ) and 10B1-p-boronophenylalanine(10B1-BPA), are found to be highly effective. The enhanced melanoma-killing effect of the 10B compounds is found by in vitro radiobiological analysis. A chemical assay and alpha-track analysis 28 h after systemic administration to melanoma-bearing hamsters reveals a 10B melanoma/blood ratio of 11.5 and a melanoma/liver ratio of 15. Establishment of a clinical therapeutic method for curing human melanoma without failure is underway by correlating biophysical, biochemical, biological, and therapeutic data analysis. Recently, the authors have also been working to develop neutron capture therapy using 10B-monoclonal antibodies for melanoma and were able to make some 10B conjugates with the specific m259-0 antibody

376

Assessment of PALB2 as a candidate melanoma susceptibility gene.  

Science.gov (United States)

Partner and localizer of BRCA2 (PALB2) interacts with BRCA2 to enable double strand break repair through homologous recombination. Similar to BRCA2, germline mutations in PALB2 have been shown to predispose to Fanconi anaemia as well as pancreatic and breast cancer. The PALB2/BRCA2 protein interaction, as well as the increased melanoma risk observed in families harbouring BRCA2 mutations, makes PALB2 a candidate for melanoma susceptibility. In order to assess PALB2 as a melanoma predisposition gene, we sequenced the entire protein-coding sequence of PALB2 in probands from 182 melanoma families lacking pathogenic mutations in known high penetrance melanoma susceptibility genes: CDKN2A, CDK4, and BAP1. In addition, we interrogated whole-genome and exome data from another 19 kindreds with a strong family history of melanoma for deleterious mutations in PALB2. Here we report a rare known deleterious PALB2 mutation (rs118203998) causing a premature truncation of the protein (p.Y1183X) in an individual who had developed four different cancer types, including melanoma. Three other family members affected with melanoma did not carry the variant. Overall our data do not support a case for PALB2 being associated with melanoma predisposition. PMID:24949998

Aoude, Lauren G; Xu, Mai; Zhao, Zhen Zhen; Kovacs, Michael; Palmer, Jane M; Johansson, Peter; Symmons, Judith; Trent, Jeffrey M; Martin, Nicholas G; Montgomery, Grant W; Brown, Kevin M; Hayward, Nicholas K

2014-01-01

377

Histology-Specific MicroRNA Alterations in Melanoma  

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We examined the microRNA signature that distinguishes the most common melanoma histological subtypes, superficial spreading melanoma (SSM) and nodular melanoma (NM). We also investigated the mechanisms underlying the differential expression of histology-specific microRNAs. MicroRNA array performed on a training cohort of 82 primary melanoma tumors (26 SSM, 56 NM), and nine congenital nevi (CN) revealed 134 microRNAs differentially expressed between SSM and NM (P<0.05). Out of 134 microRNAs, 1...

Poliseno, Laura; Haimovic, Adele; Segura, Miguel F.; Hanniford, Douglas; Christos, Paul J.; Darvishian, Farbod; Wang, Jinhua; Shapiro, Richard L.; Pavlick, Anna C.; Berman, Russell S.; Hernando, Eva; Zavadil, Jiri; Osman, Iman

2012-01-01

378

Assessment of PALB2 as a Candidate Melanoma Susceptibility Gene  

Science.gov (United States)

Partner and localizer of BRCA2 (PALB2) interacts with BRCA2 to enable double strand break repair through homologous recombination. Similar to BRCA2, germline mutations in PALB2 have been shown to predispose to Fanconi anaemia as well as pancreatic and breast cancer. The PALB2/BRCA2 protein interaction, as well as the increased melanoma risk observed in families harbouring BRCA2 mutations, makes PALB2 a candidate for melanoma susceptibility. In order to assess PALB2 as a melanoma predisposition gene, we sequenced the entire protein-coding sequence of PALB2 in probands from 182 melanoma families lacking pathogenic mutations in known high penetrance melanoma susceptibility genes: CDKN2A, CDK4, and BAP1. In addition, we interrogated whole-genome and exome data from another 19 kindreds with a strong family history of melanoma for deleterious mutations in PALB2. Here we report a rare known deleterious PALB2 mutation (rs118203998) causing a premature truncation of the protein (p.Y1183X) in an individual who had developed four different cancer types, including melanoma. Three other family members affected with melanoma did not carry the variant. Overall our data do not support a case for PALB2 being associated with melanoma predisposition. PMID:24949998

Aoude, Lauren G.; Xu, Mai; Zhao, Zhen Zhen; Kovacs, Michael; Palmer, Jane M.; Johansson, Peter; Symmons, Judith; Trent, Jeffrey M.; Martin, Nicholas G.; Montgomery, Grant W.; Brown, Kevin M.; Hayward, Nicholas K.

2014-01-01

379

Tumour to Tumour Metastasis of Malignant Melanoma to Intracranial Tumour  

Science.gov (United States)

Tumours can metastasize to sites of other tumours but this is a rare event. The phenomenon has been well described in primary tumours of the lung and breast. This has been described in melanomas but as very rare occurrence. We describe a case of a malignant melanoma that metastasized to a pre-existing meningioma. We have tried to highlight this phenomenon in patient with melanoma and need for close vigilance of other pre-existing tumours to identify early metastasis. Keywords Melanoma; Metastasis; Tumour to Tumor; Intracranial; Meningioma PMID:22481995

Shariff, Zakir; Lim, Phil; Wright, Andrew; Al-Ghazal, Sharif

2009-01-01

380

Completely regressed primary cutaneous melanoma - difficulties in diagnosis and classification.  

Science.gov (United States)

Complete regression of primary cutaneous melanoma is a very rare phenomenon. Only 49 cases of well-documented completely regressed primary cutaneous melanoma have been reported to date. The clinical picture and histological findings may vary considerably. The presence of regional lymphadenopathy represents a necessary requisite for the diagnosis of completely regressed primary cutaneous melanoma. However, some cases lie outside these criteria and are difficult to diagnose and classify. Moreover, completely regressed melanoma is not specifically referred to in the current AJCC (American Joint Commission on Cancer) melanoma staging system. We report three cases of completely regressed primary cutaneous melanoma. One of the cases presented with unquestionable clinical and histopathological findings of completely regressed primary cutaneous melanoma, but without concomitant regional lymph node metastasis. As expected, this patient eventually developed nodal metastatic disease. An extraordinary case of a completely regressed melanoma that appeared in association with a congenital melanocytic nevus is also documented. This case revealed a unique type of regression that affected only the melanoma. The nevus was left undisturbed by the immunological response. PMID:25178337

M?rg?ritescu, Irina; Chiri??, Aurel Doru; Vasilescu, Florina

2014-01-01

 
 
 
 
381

Primary malignant melanoma of the esophagus: a case report  

International Nuclear Information System (INIS)

Primary malignant melanoma of the esophagus is extremely rare, with less than 200 cases reported in the literature. However, primary malignant melanoma is an aggressive tumor. We report a case of primary esophageal malignant melanoma that presented with a large polypoid mass in the lower esophagus, and subsequently showed multiple metastatic nodules in the subcutaneous layer, skin and retroperitoneum. Primary malignant melanoma should be included in the differential diagnosis of a polypoid esophageal mass, especially in cases where metastases to unexpected areas occur or in cases of unexpected metastatic patterns

382

Irradiation of malignant eyelid melanoma with iodine 125 plaque  

Energy Technology Data Exchange (ETDEWEB)

We used contact irradiation with iodine 125 seeds to treat a large, exulcerative, nodular, amelanotic malignant eyelid melanoma with metastasis to the regional lymph nodes in an 80-year-old man. The procedure was similar to iodine 125 plaque irradiation of malignant choroidal melanoma; special equipment, however, was needed to protect the eye from radiation exposure. The response of the malignant eyelid melanoma to iodine 125 plaque irradiation was similar to that of malignant melanomas of the choroid. No complications were observed in a follow-up period of 15 months.

Stanowsky, A.; Krey, H.F.; Kopp, J.; Kanitz, W.; Wagner, T. (Eye Clinic, Central Clinic, Augsburg (West Germany))

1990-07-15

383

[Primary multiple malignant neoplasms in patients with skin melanoma].  

Science.gov (United States)

The problem of primary multiple malignant tumor (PMMT) of skin melanoma in Ukraine is analyzed. During the period from 2000 to 2006, 16760 cases of skin melanoma have been diagnosed, and in 873 patients from them PMMT has been registered. So, the part of the patients with multiple tumors among all patients with skin melanoma was 5.2%. Most often PMMT appears in the case of skin melanoma of head and neck (6.6 +/- 0.4%). Most commonly skin melanoma is accompanied by other skin malignant neoplasms (40.9 +/- 1.6% of all PMMT cases). Upon malignant skin melanoma, PMMT occurs more often in males (5.7 +/- 0.7%) than in females (4.9 +/- 0.7%). Most often the diagnosis of skin melanoma at PMMT is detected synchronously (48.3 +/- 1.6%), and simultaneous detection of PMMT predominates in all polyneoplasms and in all age groups. The most favourable course of skin melanoma is characteristic for metachronous cancer of II type when melanoma is diagnosed after manifestation of other malignant tumor. PMID:19145823

Korovin, S I; Gulak, L O; Fedorenko, Z P; Gordienko, T V; Kukushkina, M N

2008-01-01

384

Metastatic melanoma mimicking solitary fibrous tumor: report of two cases.  

Science.gov (United States)

Malignant melanomas are known for their remarkable morphological variation and aberrant immunophenotype with loss of lineage-specific markers, especially in recurrences and metastases. Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. Therefore, genotyping can be a useful ancillary diagnostic tool. We present one case each of recurrent and metastatic melanoma, both showing histological and immunohistochemical features of solitary fibrous tumor (SFT). Mutational analysis detected BRAF and NRAS mutations in the primary and secondary lesions, respectively. This result confirmed the diagnosis of recurrent/metastastic melanoma. PMID:24458518

Bekers, Elise M; van Engen-van Grunsven, Adriana C H; Groenen, Patricia J T A; Westdorp, Harm; Koornstra, Rutger H T; Bonenkamp, Johannes J; Flucke, Uta; Blokx, Willeke A M

2014-02-01

385

Primary malignant melanoma of the esophagus: a case report  

Energy Technology Data Exchange (ETDEWEB)

Primary malignant melanoma of the esophagus is extremely rare, with less than 200 cases reported in the literature. However, primary malignant melanoma is an aggressive tumor. We report a case of primary esophageal malignant melanoma that presented with a large polypoid mass in the lower esophagus, and subsequently showed multiple metastatic nodules in the subcutaneous layer, skin and retroperitoneum. Primary malignant melanoma should be included in the differential diagnosis of a polypoid esophageal mass, especially in cases where metastases to unexpected areas occur or in cases of unexpected metastatic patterns.

Lee, Jae Wook; Park, Mi Suk; Kim, Ki Whang; Pyo, Ju Yeon; Cha, Seung Hwan; Lim, Joon Seok; Kim, Myeong Jin [Yonsei University College of Medicine, Seoul (Korea, Republic of)

2007-07-15

386

Application of black salve to a thin melanoma that subsequently progressed to metastatic melanoma: a case study  

Science.gov (United States)

This is a case study of a female patient diagnosed with superficial spreading melanoma who decided to treat the lesion by the application of a preparation known as black salve. Persistence of the melanoma was documented five years later with subsequent evidence of metastatic spread to the regional lymph nodes, lungs, liver, subcutaneous tissues and musculature. A literature search has revealed one other case study of the use of black salve for the treatment of melanoma. PMID:25126466

Sivyer, Graham W.; Rosendahl, Cliff

2014-01-01

387

Immunotherapy of advanced or metastatic melanoma.  

Science.gov (United States)

Melanoma is often evaluated for the development of anticancer immunotherapeutics. Fascinating immune and clinical responses in small numbers of patients have prompted various approaches, ranging from nonspecific immune stimulation to therapies that target specific antigens. Unfortunately, these immune therapies have often shown limited success and objective responses have been seen in only a modest subset of patients. The challenge has been to identify factors that can lead to more consistent clinical benefit and to develop strategies to overcome the obstacles to successful antitumor immunity. Over the last 15 years many immune targets have been identified in cancers and the mechanisms underpinning clinical responses have become better understood. Furthermore, new ways to manipulate anticancer immunity are making it possible to overcome cancer immune evasion and subversion. New therapeutic strategies are resulting from these emerging insights into the relationship between melanoma and the host immune response. PMID:18277962

Cebon, Jonathan; Gedye, Craig; John, Thomas; Davis, Ian D

2007-12-01

388

Radiotherapy of malignant melanoma of the choroid  

International Nuclear Information System (INIS)

Twenty-two patients with choroidal melanomas were treated conservatively using radioactive radon rings with a mean follow-up of 43 months. In 14 patients there was successful tumor regression. Eight eyes were enucleated because of inadequate tumor response. Of the patients whose tumors were apparently destroyed, two have subsequently died of metastases and one eye was enucleated due to scleral rupture. Of the eight cases unsuccessfully treated, one has subsequently died of metastases. Radiation therapy is likely to be effective in patients with tumors 7 mm in diameter and 2 mm in elevation or less. Tumors larger than 12 mm in diameter and 3 mm in elevation do not respond adequately to irradiation. Relatively large doses of radiation (at least 8,000 rads to the tumor apex) must be used if the tumor is to be effectively obliterated. We believe that radiation effectively can destroy small choroidal melanomas

389

Chromatin barcodes as biomarkers for melanoma.  

Science.gov (United States)

The major barrier to effective cancer therapy is the presence of genetic and phenotypic heterogeneity within cancer cell populations that provides a reservoir of therapeutically resistant cells. As the degree of heterogeneity present within tumours will be proportional to tumour burden, the development of rapid, robust, accurate and sensitive biomarkers for cancer progression that could detect clinically occult disease before substantial heterogeneity develops would provide a major therapeutic benefit. Here, we explore the application of chromatin conformation capture technology to generate a diagnostic epigenetic barcode for melanoma. The results indicate that binary states from chromatin conformations at 15 loci within five genes can be used to provide rapid, non-invasive multivariate test for the presence of melanoma using as little as 200 ?l of patient blood. PMID:24807349

Bastonini, Emanuela; Jeznach, Magdalena; Field, Megan; Juszczyk, Katarzyna; Corfield, Emily; Dezfouli, Mehrnoush; Ahmat, Nurfilza; Smith, Aimee; Womersley, Howard; Jordan, Philip; Ramadass, Aroul; Akoulitchev, Alexandre; Goding, Colin R

2014-09-01

390

Melanoma lentiginoso acral. Reporte de un caso  

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Full Text Available Se reporta el caso de una mujer de raza blanca, ojos azules, 67 años de edad, con antecedentes de padecer de trastornos circulatorios en ambos miembros inferiores y en ocasiones de sacrolumbalgia aguda. Se desempeñó toda su vida como trabajadora agrícola en el municipio Jimaguayú, de la provincia Camagüey. Comenzó a presentar un cuadro neoplásico degenerativo en la planta del pie derecho, a punto de partida un nevo melanocítico congénito, que se diagnosticó clínica e histológicamente como un melanoma lentiginoso acral. Se describen las generalidades del melanoma lentiginoso acral, su forma de presentación, los factores predisponentes y desencadenantes que influyen en la aparición de la enfermedad, así como sus características histopatológicas y los métodos de tratamiento.

H\\u00E9ctor Oscar Victoria B\\u00E1rzaga

2008-01-01

391

The sentinel-lymphonodectomy in malignant melanoma  

International Nuclear Information System (INIS)

The concept of the removal of the sentinel lymph node (SLN) opens a new era in the primary therapy of malignant melanoma. This procedure allows an exact staging of the regional lymph nodes and selects only those patients with metastases for an early regional lymphadenectomy. Lymphoscintigraphy by Technetium-labeled human albumin and the intraoperative localization of the SLN guided by a gammaprobe combined with blue dye injections for the persecution of the lymph ways delivers optimal results. The histological proof of the often tiny micrometastases succeeds best in doing serial sectioning with confirmatory immunohistochemistry. We recommend the sentinel lymphonodectomy (SLNE) in all new diagnosed melanomas in clinical stages Ib to IIIa (DDG-classification). When finding metastases in the SLN, a radical lymphadenectomy should follow. Although a survival benefit has not yet shown, the SLNE allows to select patients for further therapies in very early stage of the disease. (orig.)

392

Oral mucosal melanoma: a malignant trap  

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Abstract Oral mucosal melanomas are highly malignant tumors. The 'chameleonic' presentation of a mainly asymptomatic condition, the rarity of these lesions, the poor prognosis and the necessity of a highly specialized treatment are factors that should be seriously considered by the involved health provider. We present the case of a 75-year-old man who was referred to the Ear, Nose and Throat department. His symptoms were voice alteration and saliva drooling, progressively worsening ...

Skoulakis Charalambos E; Malandrakis Stylianos G; Drivas Emmanouil I; Kyrmizakis Dionysios E; Bizakis John G

2006-01-01

393

Dematiaceous fungi mimicking a conjunctival melanoma.  

Science.gov (United States)

An 85-year-old, immunocompetent man was referred to the authors due to the presence of an enlarging, pigmented mass of the conjunctiva concerning for a conjunctival melanoma. Wide excision of the mass revealed a pigmented or "dematiaceous" fungus. He was treated with topical natamycin, and the lesion healed well without any evidence of recurrence. Dematiaceous fungi should be considered in the differential for pigmented conjunctival lesions. PMID:23250331

Moss, Hart B; Fowler, W Craig; Schell, Wiley A; Perfect, John R; Zedek, Dan C

2013-01-01

394

Ipilimumab for Patients With Advanced Mucosal Melanoma  

Science.gov (United States)

The outcome of patients with mucosal melanoma treated with ipilimumab is not defined. To assess the efficacy and safety of ipilimumab in this melanoma subset, we performed a multicenter, retrospective analysis of 33 patients with unresectable or metastatic mucosal melanoma treated with ipilimumab. The clinical characteristics, treatments, toxicities, radiographic assessment of disease burden by central radiology review at each site, and mutational profiles of the patients' tumors were recorded. Available peripheral blood samples were used to assess humoral immunity against a panel of cancer-testis antigens and other antigens. By the immune-related response criteria of the 30 patients who underwent radiographic assessment after ipilimumab at approximately week 12, there were 1 immune-related complete response, 1 immune-related partial response, 6 immune-related stable disease, and 22 immune-related progressive disease. By the modified World Health Organization criteria, there were 1 immune-related complete response, 1 immune-related partial response, 5 immune-related stable disease, and 23 immune-related progressive disease. Immune-related adverse events (as graded by Common Terminology Criteria for Adverse Events version 4.0) consisted of six patients with rash (four grade 1, two grade 2), three patients with diarrhea (one grade 1, two grade 3), one patient with grade 1 thyroiditis, one patient with grade 3 hepatitis, and 1 patient with grade 2 hypophysitis. The median overall survival from the time of the first dose of ipilimumab was 6.4 months (range: 1.8–26.7 months). Several patients demonstrated serologic responses to cancer-testis antigens and other antigens. Durable responses to ipilimumab were observed, but the overall response rate was low. Additional investigation is necessary to clarify the role of ipilimumab in patients with mucosal melanoma. PMID:23716015

Postow, Michael A.; Luke, Jason J.; Bluth, Mark J.; Ramaiya, Nikhil; Panageas, Katherine S.; Lawrence, Donald P.; Ibrahim, Nageatte; Flaherty, Keith T.; Sullivan, Ryan J.; Ott, Patrick A.; Callahan, Margaret K.; Harding, James J.; D'Angelo, Sandra P.; Dickson, Mark A.; Schwartz, Gary K.; Chapman, Paul B.; Gnjatic, Sacha; Wolchok, Jedd D.; Hodi, F. Stephen

2013-01-01

395

Recent advances in diagnosing cutaneous melanomas  

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Early detection of lesions while minimising the unnecessary removal of benign lesions is the clinical aim in melanoma diagnosis. In this context, several non-invasive diagnostic modalities, such as dermoscopy, total body photography, and reflectance confocal microscopy have emerged in recent years aiming at increasing diagnostic accuracy. The main developments in this field are the integration of dermoscopy and digital photography into clinical practice.

Wurm, Elisabeth Mt; Curchin, Claudia Es; Soyer, H. Peter

2010-01-01

396

I-125 ellipticines as melanoma imaging radiopharmaceuticals  

International Nuclear Information System (INIS)

Polycyclic nitrogen heterocyclics such as ellipticine are high affinity binders to melanin and DNA. In search of a melanoma imaging agent the authors developed syntheses for I-125 analogs within two new classes of this anti-tumor agent. One of these substances displayed marked anti-tumor activity, strong DNA binding, a 10/1 tumor/blood and a 25/1 eye/blood ratio at 48 hrs post-dosing

397

Gallium-67 scanning for malignant melanoma  

International Nuclear Information System (INIS)

Melanoma is characterized by a tendency to metastasize widely throughout the body and its relative affinity for gallium-67. Because of the ability of this nuclide to image tumor sites in numerous organ systems, it has been used to detect metastases in patients with malignant melanoma. The effectiveness of this technique, however, has been controversial. This article documents the retrospective analysis of results from 296 gallium-67 scintiscans from 222 patients with melanoma. Patients were placed in two groups. The low suspicion group (148 patients undergoing 191 scans) consisted of patients with no evidence of disease; the gallium scans were performed solely for screening purposes. There were 175 true-negative scans, nine true-positive scans (eight of the nine were positive only at the untreated primary site), three false-negative scans, and four false-positive scans. Therefore, in only one patient (0.5%) did a screening gallium scan reveal disease that was not expected. The high suspicion group (85 patients undergoing 105 scans) consisted of patients with established evidence of metastatic disease; the gallium scan was performed to confirm those findings and to search for involvement of other organ systems. Of these scans, ten were true-negative, 73 true-positive, 21 false-negative, and one false-positive. In this group the 20% false-negative results indicate that gallium scanning is considerably less sensitive than the combination of clinical and standard radiograbination of clinical and standard radiographic assessment. It was concluded that gallium-67 scintiscanning of patients with melanoma, whether for screening or evaluation of patients with known metastases, provides little information that affects clinical staging or therapeutic design. Therefore, the technique is of limited value for routinely investigating the extent of disease

398

Optimizing local control in anorectal melanoma  

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Full Text Available Background: Wide local excision (WLE of anorectal melanoma is associated with a high incidence of local recurrence. There is a paucity of literature on adjuvant radiation in this malignancy. Aim: To identify the optimal method of local treatment in anorectal melanoma. Settings and Design: Retrospective study in a tertiary cancer centre. Materials and Methods: Records of 63 patients who presented between 1980 and 2004 were reviewed. Results: Of the 63 patients, 18 were treated by either surgery with or without adjuvant radiation, or by radiation alone. The remaining had advanced disease and were offered only symptomatic treatment. The median overall survival in stage I patients was 12 months, while it was seven and four months in those with stage II and III disease respectively. The median survival in patients treated by WLE with adjuvant radiation (RT, WLE alone or Abdominoperineal resection (APR was 34, 12 and 10 months respectively. Patients in whom the disease was confined to the mucosa had a better median overall survival than those in whom it had infiltrated beyond the mucosa (102 vs 11 months. The pattern of recurrence following WLE with adjuvant RT or APR was similar. None of the patients who received adjuvant RT after wide excision had a local or nodal recurrence. Conclusion: Local treatment of anorectal melanoma should be individualized. WLE with adjuvant radiation seems to offer good locoregional control without reducing the survival and may be an option of treatment for patients with small, superficial anorectal melanoma. However, APR should be offered for patients with locally advanced disease or as a salvage following recurrence.

Ramakrishnan A

2008-01-01

399

Melanoma developed during pregnancy - A case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english We describe a case of plantar interdigital cutaneous melanoma in a 22-year-old woman who reported changes in a pigmented lesion during pregnancy. Diagnosis was late and evolution unfavourable. The purpose of this report is to draw the attention of dermatologists to the need for careful regular exami [...] nation of melanocytic lesions in pregnant women, not ignoring possible changes as always physiological.

Natalia Cammarosano, Mestnik; Joao Paulo Junqueira Magalhaes, Afonso; Milvia Maria Simoes e Silva, Enokihara; Mauro Yoshiaki, Enokihara; Adriana Maria, Porro; Sergio Henrique, Hirata.

400

Pediatric Melanoma: Analysis of an International Registry  

Science.gov (United States)

BACKGROUND The management of pediatric melanoma (PM) has largely been extrapolated from adult data. However, the behavior of PM appears to differ from its adult counterparts. Therefore, an international PM registry was created and analyzed. METHODS Twelve institutions contributed deidentified clinicopathologic and outcome data for patients diagnosed with PM from 1953 through 2008. RESULTS Overall survival (OS) data were reported for 365 patients with invasive PM who had adequate follow-up data. The mean age of the patients was 16 years (range 1 year-21 years). The 10-year OS rate, 80.6%, tended to vary by patient age: 100% for those aged birth to 10 years, 69.7% for those aged > 10 years to 15 years, and 79.5% for those aged > 15 years to 20 years (P =.147). Patients with melanomas measuring ? 1 mm had a favorable prognosis (10-year OS rate of 97%), whereas survival was lower but similar for patients with melanomas measuring > 1 mm to 2 mm, > 2 mm to 4 mm, and > 4 mm (70%, 78%, and 80%, respectively; P =.0077). Ulceration and lymph node metastasis were found to be correlated with worse survival (P =.022 and P =.017, respectively). The 10-year OS rate was 94.1% for patients with American Joint Committee on Cancer stage I disease, 79.6% for those with stage II disease, and 77.1% for patients with stage III disease (P 10 years. Further analyses are needed to probe for potential biological and behavioral differences in pediatric versus adult melanoma. PMID:24022819

Averbook, Bruce J.; Lee, Sandra J.; Delman, Keith A.; Gow, Kenneth W.; Zager, Jonathan S.; Sondak, Vernon K.; Messina, Jane L.; Sabel, Michael S.; Pittelkow, Mark R.; Ecker, Phillip M.; Markovic, Svetomir N.; Swetter, Susan M.; Leachman, Sancy A.; Testori, Alessandro; Curiel-Lewandrowski, Clara; Go, Ronald S.; Jukic, Drazen M.; Kirkwood, John M.

2014-01-01

 
 
 
 
401

Prognosis of mucous naso-sinus melanomas  

International Nuclear Information System (INIS)

Purpose: The mucous melanoma of superior aero-digestive tracts represents 1-2% of malignant melanomas, 5-10% of head and neck melanomas, and concerns particularly, the nasal cavities and naso-sinus cavities. The recurrences are frequent, often local ones, sometimes multifocal ones, the survival rate at five years is ? 30%. The Ballantyne classification distinguishes three stages: 1 localised tumors, 2 ganglions attack, 3 metastases. Are pejorative: a stage number 3 ( deep invasion, muscles, bones, cartilages) according to the Prasad classification (1: in situ or micro invasive, 2: invasion of the lamina propria), the achromia sub-type, a pseudo papillary or sarcoma, vascular emboli, necrosis. The recommendations rest on evidence level at 4. The complete excision is the rule and must be counterbalanced with the morbidity in case of orbital, dura-mater, frontal lobe, and infra temporal fossa. The adjuvant irradiation is debated.We evaluated the prognosis of mucous naso-sinus melanomas. Conclusion: The principal cause of death was the local failure. The Ballantyne classification does not take into account the extensions and overestimates the prognosis impact of ganglions invasion that is yet ?10% ( and does not justify a radiotherapy in lack of adenopathy). It underestimates probably the impact of adjuvant radiotherapy. One should be able to distinguish the unfavourable stage 1 tumors (receiving eventually a radiotherapy) and these ones of very localised stage 1 for se ones of very localised stage 1 for which it could be omitted. The fractionation and the optimal dose remain to be defined. The volume ?100 ml and the irradiation by carbon ions seem promising in term of local control but the metastases stay a problem in the recent series. (N.C.)

402

Plasma 25-Hydroxyvitamin D and Risk of Non-Melanoma and Melanoma Skin Cancer : A Prospective Cohort Study  

DEFF Research Database (Denmark)

Sun exposure is a major risk factor for skin cancer and is also an important source of vitamin D. We tested the hypothesis that elevated plasma 25-hydroxyvitamin D (25-OH-vitD) associates with increased risk of non-melanoma and melanoma skin cancer in the general population. We measured plasma 25-OH-vitD in 10,060 white individuals from the Danish general population. During 28 years of follow-up, 590 individuals developed non-melanoma skin cancer and 78 developed melanoma skin cancer. Increasing 25-OH-vitD levels, by clinical categories or by seasonally adjusted tertiles, were associated with increasing cumulative incidence of non-melanoma skin cancer (trend P=2 × 10(-15) and P=3 × 10(-17)) and melanoma skin cancer (P=0.003 and P=0.001). Multivariable adjusted hazard ratios of non-melanoma skin cancer were 5.04 (95% confidence interval (CI): 2.78-9.16) for 25-OH-vitD ?50 vs. 60 years, 25-OH-vitD winter levels ?50?nmol?l(-1), and performing outdoor exercise. In conclusion, we show that increasing levels of 25-OH-vitD are associated with increased risk of non-melanoma and melanoma skin cancer.Journal of Investigative Dermatology advance online publication, 29 November 2012; doi:10.1038/jid.2012.395.

Afzal, Shoaib; Nordestgaard, BØrge G

2013-01-01

403

Gamma knife radiosurgery for uveal melanoma ineligible for brachytherapy by the Collaborative Ocular Melanoma Study criteria  

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Full Text Available Nicola G Ghazi1, Christopher S Ketcherside1, Jason Sheehan2, Brian P Conway11Department of Ophthalmology and 2Neurosurgery, University of Virginia Health System, Charlottesville, VA, USAPurpose: To report outcomes of Gamma Knife radiosurgery (GKRS in treating uveal melanoma lesions ineligible for standard brachytherapy.Methods: A retrospective interventional case series of uveal melanoma patients treated with GKRS between 1996 and 2004 was performed. The main outcome measures were local tumor control, metastasis, and death.Results: Four patients with uveal melanoma treated with GKS were identified. Three tumors involved the ciliary body and one was macular with its border within 2 mm of the optic disc. Adequate globe stabilization was achieved by retrobulbar anesthesia in all cases. Pretreatment mean visual acuity was 20/30. Tumor volume as determined by magnetic resonance imaging ranged from 0.05 to 0.30 cc. Ultrasonographic greatest tumor diameter and height ranged from 11 to 18 mm (mean 14.5 mm and 2.9 to 4.5 mm (mean 3.6 mm, respectively. The peripheral dose varied from 16.5 to 30 Gray. Local tumor control was achieved in all cases over a follow up period of 6 to 96 months. Mean final visual acuity was 20/50. One eye was enucleated for neovascular glaucoma and one patient died from liver and lung metastasis.Conclusions: GKRS for uveal melanoma appears to be safe and effective. The metastasis and mortality rates appear to be comparable to those following brachytherapy and enucleation. Moreover, local tumor control and enucleation rates are similar to those following brachytherapy. The findings in this small series suggest a role for GKRS in the treatment of selected cases of uveal melanomas.Keywords: gamma knife radiosurgery, radiation therapy, uveal melanoma

Nicola G Ghazi

2008-09-01

404

Ultrasonic characterisation of malignant melanoma of choroid.  

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An in-vitro study of wave spectral analysis in 8 enucleated eyes was conducted in order to differentiate histological subtypes of malignant melanoma. To obtain the backscattering coefficient for the tissues, we used a broadband focussed transducer with a frequency range of 7-12 MHz and a centre frequency of 10 MHz. Experimental measurement of backscattering coefficient and attenuation coefficient at various frequencies was done by substitution techniques. The backscattering coefficient, scatterer size, and root mean square velocity fluctuation were derived by the numerical method, while the attenuation coefficient at 1 MHz was derived from attenuation coefficient at different frequencies. This study revealed that backscattering coefficient and attenuation coefficient, over a frequency range of 7-12 MHz, show an increase in the spindle cell type compared to the mixed cell type of malignant melanoma. Particularly, the scatterer size was significantly higher in the spindle cell group (p = 0.013) in contrast to the mixed cell type. Spindle cells have uniform and compact histological pattern which contributes to an increase in scatterer size and root mean square velocity fluctuation. The ultrasonically obtained parameters have been shown to have a good correlation with the histology of malignant melanoma. PMID:10085628

John, S; Sujana, H; Suresh, S; Swarnamani, S; Biswas, J; Gopal, L

1998-09-01

405

Positron emission tomography of choroidal melanoma  

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We used positron emission tomography (PET) as an aid in determining whether an enlarging choroidal melanoma was viable after ophthalmic plaque thermoradiotherapy. Radioactively labelled glucose (18-F fluorodeoxyglucose (18F-FDG)) was injected into our patient for scanning. The PET evaluation revealed no evidence of increased 18F-FDG uptake in the region of the choroidal melanoma. This result supported our clinical decision to observe for continued tumor enlargement prior to re-treatment. PET offers the potential to determine whether a tumor is viable after treatment. PET has used injectable radioactive metabolites to image metabolically active tissues. Thus, clinical applications of PET have focused on its` ability to determine whether tumors were metabolically active before and after treatment. Since each patients tumor will likely differ in sensitivity to treatment, PET may offer a better end point to therapy. After radiotherapy of uveal melanoma, local control has been defined as cessation of growth or reduction in tumor size as documented by ophthalmoscopy and/or ultrasonography. If a cancer has been documented to enlarge in anatomic size, it has been considered viable. Post-treatment tumor enlargement can also be caused by radiation induced vasculopathy with hemorrhage, exudation and edema within the tumor. A physiologic assay of tissue function as provided by PET may offer a better method to differentiate the causes of post-treatment tumor enlargement. (author) 5 refs, 2 figs

Finger, P.T.; D`Arienso, P.; Moshfeghi, D.; Packer, S.; Perry, H.D. [North Shore University Hospital, Manhasset, NY (United States); Czechonska, G. [General Hospital, Warsaw (Poland); Dhawan, V. [Department of Neurology, North Shore University Hospital - Cornell University Medical College, Manhasset, New York (United States); Margouleff, D. [Department of Nuclear Medicine, North Shore University Hospital - Cornell University Medical College, Manhasset, New York (United States)

1996-12-31

406

Cutaneous melanoma of the head and neck.  

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Seventy patients surgically treated in The Netherlands Cancer Institute between 1969 and 1984 for cutaneous melanoma of the head and neck were reviewed with regard to patient data, tumor site, stage, histological criteria, treatment, disease-control and survival. The objectives of the study were to analyse the results of curative treatment of cutaneous melanoma of the head and neck, the value of prognostic factors and the treatment policy for the N0 and N+ neck. Tumor thickness (Breslow Index) was by far the most important prognostic factor in cutaneous melanoma of the head and neck. Other known important factors like level of invasion, tumor subsite, stage, tumor type and ulceration provided additional information. Elective node dissection is advised in lesions thicker than 1.5 mm since N0-N+ transformation is seen in 37% of these patients. Partial neck dissection which includes removal of the nodes adjacent to the primary provides proper regional control except for primary lesions in the neck that require at least a modified neck dissection. PMID:3360158

Vreeburg, G C; Schouwenburg, P F; Hilgers, F J; de Kraker, N W; Hart, A A

1988-04-01

407

Cutaneous melanoma: new advances in treatment  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Cutaneous melanoma is a challenge to treat. Over the last 30 years, no drug or combination of drugs demonstrated significant impact to improve patient survival. From 1995 to 2000, the use of cytokines such as interferon and interleukin become treatment options. In 2011, new drugs were approved by th [...] e U.S. Food and Drug Administration, including peginterferon alfa-2b for patients with stage III disease, vemurafenib for patients with metastatic melanoma with the BRAF V600E mutation, and ipilimumab, a monoclonal antibody directed to the CTLA-4 T lymphocyte receptor, to combat metastatic melanoma in patients who do not have the BRAF V600E mutation. Both ipilimumab and vemurafenib showed results in terms of overall survival. Other trials with inhibitors of other genes, such as the KIT gene and MEK, are underway in the search for new discoveries. The discovery of new treatments for advanced or metastatic disease aims to relieve symptoms and improve patient quality of life.

Michele Ceolin, Foletto; Sandra Elisa, Haas.

2014-04-01

408

Ultrasonic characterisation of malignant melanoma of choroid  

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Full Text Available An in-vitro study of wave spectral analysis in 8 enucleated eyes was conducted in order to differentiate histological subtypes of malignant melanoma. To obtain the backscattering coefficient for the tissues, we used a broadband focussed transducer with a frequency range of 7-12 MHz and a centre frequency of 10 MHz. Experimental measurement of backscattering coefficient and attenuation coefficient at various frequencies was done by substitution techniques. The backscattering coefficient, scatterer size, and root mean square velocity fluctuation were derived by the numerical method, while the attenuation coefficient at 1 MHz was derived from attenuation coefficient at different frequencies. This study revealed that backscattering coefficient and attenuation coefficient, over a frequency range of 7-12 MHz, show an increase in the spindle cell type compared to the mixed cell type of malignant melanoma. Particularly, the scatterer size was significantly higher in the spindle cell group (p = 0.013 in contrast to the mixed cell type. Spindle cells have uniform and compact histological pattern which contributes to an increase in scatterer size and root mean square velocity fluctuation. The ultrasonically obtained parameters have been shown to have a good correlation with the histology of malignant melanoma.

John Sheila

1998-01-01

409

Primary cutaneous melanoma: an 18-year study  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english BACKGROUND: Primary cutaneous melanoma still constitutes the main cause of skin cancer death in developed countries, and its incidence in recent years has been increasing in a steady, worrisome manner. OBJECTIVES: This study evaluated the clinical, epidemiological and demographic aspects of this dis [...] ease, and correlated them with patient prognosis. METHODS: Using epidemiologic and clinical data, we analyzed 84 patients with mild to severe primary cutaneous melanoma treated between 1990 and 2007. Slides containing surgical specimens were analyzed, and new slides were made from archived paraffin sections when necessary. RESULTS: The melanoma incidence was higher in areas of sun exposure, with lesions commonly observed in the trunk for males, and lower limbs for females. In addition to Breslow's thickness and ulceration (p = 0.043 and p 1 mm and 4 mm) and the mitotic index (0 when absent or 1 when >1 per mm²) allowed the establishment of a prognostic score: if the sum was equal to or over three, nearly all (91.7%) patients had systemic disease. The 5-year survival was approximately seventy percent. CONCLUSION: Because American Join Committee of Cancer Staging will update the classification of malignant tumors (TNM) staging in the near future, and introduce mitosis as a prognostic factor, our results show the importance of such a feature. Additional studies are necessary to confirm the importance of a prognostic score as proposed herein.

Moris, Anger; Henri, Friedhofer; Marina Fussae, Fukutaki; Marcus Castro, Ferreira; Gilles, Landman.

410

Persistent Pain After Surgery for Cutaneous Melanoma  

DEFF Research Database (Denmark)

OBJECTIVES:: Chronic pain is a well-known complication after surgery, but the prevalence of persistent pain after melanoma surgery is unknown. This study examined the prevalence and predictors of persistent pain after melanoma surgery. METHODS:: Between September 2005 and June 2009, 448 patients underwent surgery for cutaneous melanoma at the Department of Plastic Surgery, Aalborg Hospital. A questionnaire was sent to all 402 survivors, and 350 (87.1%) responded. In addition, all patients with pain and a control group of sex-matched and age-matched patients without pain were invited to a clinical examination. RESULTS:: Thirty-four patients (9.7%) reported pain in the scar area within the last month, and 8.6% reported chronic pain. The pain was mostly mild with little impact on daily life, but 1.7% reported moderate to severe pain, and 3.4% reported at least moderate impact of pain on daily life. Sensory changes were reported by 108 patients (31.5%); 25% of these had pain compared with 3% of patients with normal sensation [P

HØimyr, Hilde; von Sperling, Marie Louise

2012-01-01

411

Combined treatment of uveal melanoma liver metastases  

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Full Text Available Abstract Uveal melanoma (UM is the most prevalent intraocular malignant tumor in the Western world. The prognosis of survival in the presence of metastatic disease is 2-7 months, depending on the treatment applied. This article presents a case of metastatic UM with successful complex treatment of liver metastases. A 49-year old female, underwent removal of the right eyeball in 1996 due to a histologically confirmed uveal melanoma. After 11 years, CT revealed a mass in the left kidney and multiple metastases in the liver. After left nephrectomy, 6 chemotherapy courses with dacarbazine were performed. The increasing liver metastases were observed. Additional 4 intraarterial (i/a chemotherapy courses were administered using cisplatin, doxorubicin, fluorouracil, and interferon alfa. After few courses increase in CTC Grade 4 liver transaminases was seen. A partial response was observed, and in December 2008 the patient underwent surgery removing all liver metastases by 7 wedge or atypical resections. All margins were tumor-free. 21 months after liver resections and 14 years since diagnosis, the patient is alive without evidence of disease. Successful treatment of metastatic uveal melanoma was due to a timely application of a combination of several treatment methods and good prognostic factors of the patient.

Brasiuniene B

2011-02-01

412

Sentinel lymph node biopsy in cutaneous melanoma Biópsia do linfonodo sentinela no melanoma cutâneo  

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PURPOSE: To assess the importance of sentinel lymph node biopsy in patients with cutaneous melanoma. METHODS: Ninety consecutive non-randomized patients with stages I and II melanoma who underwent sentinel lymph node biopsy were followed up prospectively for six years. RESULTS: Patients were followed up for a mean period of 30 months. Their mean age was 53.3 years, ranging from 12 to 83 years. Thirty patients were male (37.5%) and 50, female (62.5%). Sentinel lymph node was positive in 32.5% ...

Andrea Fernandes de Oliveira; Ivan Dunshee Abranches Oliveira Santos; Thaís Cardoso de Mello Tucunduva; Luciana Garbelini Sanches; Renato Santos Oliveira Filho; Silva Enokihara, Mi?lvia Maria Simo?es E.; Lydia Masako Ferreira

2007-01-01

413

Melanoma primario del esófago Primary esophageal melanoma. Report of one case  

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Full Text Available El melanoma primario maligno del esófago es extremadamente raro y menos de 300 casos han sido publicados hasta el momento. Aunque la resección quirúrgica ha sido considerada como la mejor opción, el pronóstico es muy pobre. Se presenta a un paciente de 70 años a quien se le realizó una esofagogastroscopía por disfagia y epigastralgia de 6 meses de evolución. No había antecedentes de melanoma cutáneo. El examen demostró una masa polipoidea pigmentada de 5 cm de diámetro en el tercio inferior del esófago, que la biopsia informó como melanoma maligno. Se realizó una esofagectomía transhiatal y el estómago fue reemplazado por un tubo gástrico isoperistáltico con una anastomosis esofagogástrica cervical. El estudio de la pieza operatorio demostró un tumor polipoideo de 5,5 cm, con pigmentación negra. El estudio histológico demostró que el tumor correspondía a un melanoma maligno primario del esófago. Los márgenes de resección oral y caudal estaban libres de tumor. No recibió terapia adyuvante complementaria y a los 3 meses de la intervención había signos clínicos e imagenológicos de recurrencia de la enfermedad.Primary malignant melanoma of the esophagus is an extremely rare tumor. Less than 300 cases have been published worldwide. Although surgical excision is the best possible therapeutic option, the prognosis is poor. We report a 70 years oíd man, who underwent an esophagoscopy due to a 6-months history of dysphagia and upper abdominal discomfort. There was no history of previous cutaneous melanoma. A polypoid and pigmented mass (of 5 cm diameter almost completely occluding the lumen in the lower fhird of the esophagus, was found. The histological diagnosis of the initial biopsy was melanoma. Transhiatal esophagectomy was performed and the esophagus was replaced by an isoperistaltic gastric tube with cervical esophageal anastomosis. The excised specimen showed a polypoid tumor with black pigmentation of 5.5 cm. The diagnosis of pathological and immunohistochemical studies was a primary esophageal malignant melanoma. The resection margins of esophagus were free of tumor. He received no postoperative adjuvant therapy and signs of recurrence were observed 3 months after the operation.

RIMSKY ÁLVAREZ U

2009-04-01

414

Melanoma nodular en borde de pie / Nodular melanoma on foot edge  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: el melanoma cutáneo es un tumor maligno originado en los melanocitos, cuya incidencia y mortalidad han aumentado en las últimas décadas. Es la causa más frecuente de muerte entre las enfermedades cutáneas, y responsable del 75% de éstas. La mayoría se originan en la piel sana, sobre un [...] nevo u otros órganos. Es una tumoración de alta agresividad y con tendencia a la metástasis linfática o hemática. El melanoma nodular representa el 15-35% de estos tumores, afectando áreas de piel fotoprotegidas, con fase de crecimiento vertical, lo cual condiciona su comportamiento tan agresivo y peor pronóstico. Presentación del caso: paciente anciana, con lesión tumoral en pie derecho, asintomática, de cuatro años de evolución, con crecimiento rápido en los últimos tres meses. Se realiza diagnóstico clínico-histopatológico, compatible con melanoma nodular. El tratamiento de elección es la extirpación quirúrgica. Conclusiones: el melanoma nodular es un tumor muy agresivo y la supervivencia depende de un diagnóstico precoz, posibilitando la cura de más del 90% de los casos. Abstract in english Introduction: cutaneous melanoma is a malignant tumor originated from melanocytes, whose incidence and mortality rates have increased in recent decades. It is the most common cause of death among skin diseases, and accounts for its 75%. Most of them originate in healthy skin on a nevus or other orga [...] ns. It is a highly aggressive tumor with a tendency to lymphatic or hematogenous metastases. Nodular melanoma accounts for 15 to 35% of these tumors, affecting photo-protected areas of skin, with vertical growth phase, which determines their behavior as aggressive and its worse prognosis. Case report: old patient with right foot tumor injury, asymptomatic, four years of evolution, with rapid growth in the last three months. Clinical and histopathological diagnosis is made, compatible with nodular melanoma. The treatment of choice is surgical removal. Conclusions: nodular melanoma is a very aggressive tumor and survival depends on early diagnosis, allowing the cure of more than 90% of the cases.

Carlos Alberto, Blanco Córdova.

2014-04-01

415

Melanoma nodular en borde de pie / Nodular melanoma on foot edge  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: el melanoma cutáneo es un tumor maligno originado en los melanocitos, cuya incidencia y mortalidad han aumentado en las últimas décadas. Es la causa más frecuente de muerte entre las enfermedades cutáneas, y responsable del 75% de éstas. La mayoría se originan en la piel sana, sobre un [...] nevo u otros órganos. Es una tumoración de alta agresividad y con tendencia a la metástasis linfática o hemática. El melanoma nodular representa el 15-35% de estos tumores, afectando áreas de piel fotoprotegidas, con fase de crecimiento vertical, lo cual condiciona su comportamiento tan agresivo y peor pronóstico. Presentación del caso: paciente anciana, con lesión tumoral en pie derecho, asintomática, de cuatro años de evolución, con crecimiento rápido en los últimos tres meses. Se realiza diagnóstico clínico-histopatológico, compatible con melanoma nodular. El tratamiento de elección es la extirpación quirúrgica. Conclusiones: el melanoma nodular es un tumor muy agresivo y la supervivencia depende de un diagnóstico precoz, posibilitando la cura de más del 90% de los casos. Abstract in english Introduction: cutaneous melanoma is a malignant tumor originated from melanocytes, whose incidence and mortality rates have increased in recent decades. It is the most common cause of death among skin diseases, and accounts for its 75%. Most of them originate in healthy skin on a nevus or other orga [...] ns. It is a highly aggressive tumor with a tendency to lymphatic or hematogenous metastases. Nodular melanoma accounts for 15 to 35% of these tumors, affecting photo-protected areas of skin, with vertical growth phase, which determines their behavior as aggressive and its worse prognosis. Case report: old patient with right foot tumor injury, asymptomatic, four years of evolution, with rapid growth in the last three months. Clinical and histopathological diagnosis is made, compatible with nodular melanoma. The treatment of choice is surgical removal. Conclusions: nodular melanoma is a very aggressive tumor and survival depends on early diagnosis, allowing the cure of more than 90% of the cases.

Carlos Alberto, Blanco Córdova.

416

Significance of vascular endothelial growth factor expression in skin melanoma  

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Full Text Available Background/Aim. Melanoma is a heterogeneous disease of skin and mucous membranes which shows significant increase in incidence worldwide in the past decades. In the process of forming new blood vessels stimulators of angiogenesis participate. There is an increase production of vascular endothelial growth factor (VEGF-C and VEGF-D, which expression cause change of endothelial cells, and higher degree of tumor's aggressiveness. The aim of this research was to determine the level of VEGF expression in skin melanoma in different body regions and in different primary stages of the disease. Methods. The research was conducted on bioptic materials of skin in 39 patients. On excision-made materials a routine histological preparation was done and following parameters were determined: histological type, alteration thickness (according to Breslow, Clark level, TNM (Tumor Nodus Metastasis stage (pT, alteration width, thickness of lymphocytic infiltration in the tumor, mitotic index, phase of the tumor growth, presence of ulcerations, cellular type of the tumor, localization and level of VEGF expression. Results. Analysis confirmed that 61.54% of skin melanoma showed a high VEGF expression. Nodular and acral lentiginous melanomas showed more frequently a high level of VEGF expression, while superficial spreading melanoma showed a lower level of VEGF expression (p = 0.032, p < 0.05. A higher level of expression was present in thicker melanomas (higher in the Breslow stage; p = 0.011, p < 0.05. The width of the lesion did not have an influence on the level of VEGF expression in melanoma (U =142.000, p = 0.273. Conclusion. Melanomas show a higher level of VEGF expression. Nodular and acral lentiginous types of melanoma show a high level of VEGF expression, while superficial spreading melanoma shows a lower level of VEGF expression. Melanomas in higher-stage disease (Breslow, Clark, pTNM show a higher level of VEGF expression.

Gajanin Vesna

2010-01-01

417

Neoplasias múltiples en pacientes afectos de melanoma de úvea Multiple neoplasms in patients with uveal melanoma  

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Full Text Available Objetivo: Estudiar la prevalencia de neoplasias múltiples en pacientes afectos de melanoma de úvea en nuestro medio y relacionarlo con la supervivencia. Método: Para ello se ha realizado un estudio prospectivo longitudinal de prevalencia de múltiples neoplasias en pacientes diagnosticados de melanoma de úvea entre los años 1984-2005. Se han analizado entre otras las variables clínicas: edad, sexo, fecha de diagnóstico, ojo afecto, origen y tamaño tumoral, clasificación según el COMS (Collaborative Ocular Melanoma Study, fecha del último control, tiempo de seguimiento, presencia de otras neoplasias, estado sistémico actual, fecha y causa de muerte. Resultados: Se han estudiado 305 pacientes afectos de melanoma de úvea en la Unidad de Oncologia Ocular de nuestro centro. 24 pacientes (7,9% presentaron en su historia médica una o más neoplasias malignas. Excluyendo las neoplasias cutáneas de origen en células basales, esta proporción fue del 7,2% (22 pacientes. No se ha encontrado diferencias estadísticamente significativas entre la edad de presentación, sexo y la localización del melanoma (cuerpo ciliar o coroides y la presencia o no de segundas neoplasias. Cuando se analizó la proporción de pacientes con enfermedad metastásica (tanto vivos como muertos que no han presentado una segunda neoplasia (14,3%, respecto de aquellos que si la presentaron (40,9%, mediante el test de Chi-cuadrado, se encontró una relación estadísticamente significativa con una p=0,004. Conclusiones: En nuestra población de estudio, se ha observado un porcentaje de segundas neoplasias similar al descrito en otras series internacionales. No se ha encontrado una mayor proporción de segundas neoplasias según el sexo, la edad, la localización tumoral. Así como tampoco se ha observado una mayor frecuencia de determinadas segundas neoplasias. Pero sí que se ha evidenciado una mayor predisposición a desarrollar enfermedad metastásica, en los pacientes que han presentado segundas neoplasias, por lo que en estos pacientes se debe incrementar el seguimiento sistémico.Purpose: To study the prevalence of multiple neoplasms in patients affected by uveal melanoma in Spain and to relate these with survival. Method: We carried out a longitudinal prospective study of the prevalence of multiple neoplasms in patients diagnosed to have a uveal melanoma during the years 1984-2005. The data has been analysed for the following variables: age, sex, date of diagnosis, affected eye, origin and tumoral size, classification according to COMS (Collaborative Ocular Melanoma Study, time of follow-up, presence of other neoplasms, current clinical state, date and cause of death. Results: Three hundred and five patients affected by uveal melanoma have been studied in the Ocular Oncology Unit of our institution; 24 patients (7.9% had evidence in their medical reports of one or more additional neoplasms. Excluding cutaneous neoplasms originating in basal cells, this number reduced to 22 patients (7.2%. We did not find any statistically significant differences among the presentation age, sex or localization of the melanoma (ciliary body or choroid and the presence or absence of a second neoplasm. When we analysed the proportion of patients with metastatic disease (both alive and dead who presented with a second neoplasm (40.9%, we found a statistically significant relationship between these variables (Chi-square test, p=0.004. Conclusions: We have observed a percentage of second neoplasms similar to that described in other international studies. We did not find a larger proportion with a second neoplasm according to the sex, age, or tumoral localization, nor did we observe a higher frequency of any particular second neoplasm. We have defined a relationship between metastasic uveal melanoma, and the development of a second neoplasm, which clearly indicates a need for increased systemic follow-up in such patients.

J.M. Caminal

2007-09-01

418

Responses of B-16 mouse melanoma to nuclear reactor beams  

International Nuclear Information System (INIS)

Responses of B-16 mouse melanoma to nuclear reactor beams and x-ray were compared. Responses of B-16 mouse melanoma were measured by the tumor volume method. X-ray and nuclear reactor beams obtained from Kyoto University Reactor thermal neutron field were irradiated in divided doses twice at an interval of 24 hours. Responses of B-16 mouse melanoma were expressed as dose-survival curves of melanoma B-16. The D37 and D sub(q) values were 9.7 Gy and 7.0 Gy, respectively. The surviving fraction of B-16 mouse melanoma irradiated with x-ray in divided doses did not differ markedly from the dose-survival curve of B-16 mouse melanoma irradiated with x-ray in single dose. Responses of B-16 mouse melanoma to nuclear reactor beams were also expressed as dose-survival curves. The D37 and D sub(q) values were 5.1 Gy and 3.0 Gy, respectively. The surviving fraction of B-16 mouse melanoma irradiated with nuclear reactor beams in divided doses hardly differed from those irradiated in single dose. (Tsunoda, M.)

419

Complete infarction of the eye complicating a choroidal malignant melanoma.  

Science.gov (United States)

Infarction of malignant melanoma of the choroid has been previously reported, but infarction of the whole eye in association with infarction of melanoma is a rare event that has not been previously described. We present such a case and discuss the possible pathogenesis. Images PMID:1873265

Jones, H; Manners, R; Elkington, A R; Weller, R O

1991-01-01

420

Increased HOX C13 expression in metastatic melanoma progression  

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Full Text Available Abstract Background The process of malignant transformation, progression and metastasis of melanoma is not completely understood. Recently, the microarray technology has been used to survey transcriptional differences that might provide insight into the metastatic process, but the validation of changing gene expression during metastatic transition period is poorly investigated. A large body of literature has been produced on the role of the HOX genes network in tumour evolution, suggesting the involvement of HOX genes in several types of human cancers. Deregulated paralogous group 13 HOX genes expression has been detected in melanoma, cervical cancer and odonthogenic tumors. Among these, Hox C13 is also involved in the expression control of the human keratin genes hHa5 and hHa2, and recently it was identified as a member of human DNA replication complexes. Methods In this study, to investigate HOX C13 expression in melanoma progression, we have compared its expression pattern between naevi, primary melanoma and metastasis. In addition HOXC13 profile pattern of expression has been evaluated in melanoma cell lines. Results Our results show the strong and progressive HOX C13 overexpression in metastatic melanoma tissues and cytological samples compared to nevi and primary melanoma tissues and cells. Conclusions The data presentated in the paper suggest a possible role of HOX C13 in metastatic melanoma switch.

Cantile Monica

2012-05-01

 
 
 
 
421

Adolescent girl with Down syndrome and lumbar cutaneous melanoma.  

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Melanoma has rarely been reported in people with Down syndrome, and its frequency in this condition has not been clearly established. We report a 19-year-old woman with Down syndrome and lumbar melanoma. This possible association must be kept in mind. PMID:22639836

Satgé, Daniel; Dimoux-Dime, Guy; Godard, William; de Fréminville, Bénédicte

2014-01-01

422

The role of ultraviolet light in the origin of melanomas  

International Nuclear Information System (INIS)

The study described in this report enters into a number of possible functions of UV radiation in the arising of melanomas. From the results it turns out that UV radiation probably does not induce melanomas directly, which pleads for a more direct function of UV radiation possibly via suppression of the defence system against tumour cells. (H.W.). 20 refs

423

Prevalence of left-sided melanomas in an Irish population.  

LENUS (Irish Health Repository)

BACKGROUND: A predominance of melanomas on the left side of the body has recently been described. No associations between tumour laterality and gender, age or anatomical site have been identified. AIM: The aim of this study was to investigate the prevalence of left-sided melanomas in an Irish population and to examine potential associations with various patient and tumour characteristics. METHODS: A retrospective chart review of patients with cutaneous melanoma who were treated over a 10-year period was carried out. Lateral distribution of melanoma on either side of the body was compared using ?(2) analysis and evaluated by gender, age group, anatomic location, histologic subtype and Breslow depth. RESULTS: More melanomas occurred on the left side (57%, P = 0.015), and this finding was particularly significant in females. For both genders combined, there were no statistically significant differences in laterality by age group, anatomic location, type of melanoma and Breslow depth. There were significantly more superficial spreading melanomas on the left side in both men and women. CONCLUSIONS: This study demonstrates a predominance of left-sided melanomas in Irish patients. While a number of demographic and molecular associations have been proposed, further research is required to fully explain this phenomenon.

de Blacam, C

2011-04-17

424

Prevalence of left-sided melanomas in an Irish population.  

LENUS (Irish Health Repository)

BACKGROUND: A predominance of melanomas on the left side of the body has recently been described. No associations between tumour laterality and gender, age or anatomical site have been identified. AIM: The aim of this study was to investigate the prevalence of left-sided melanomas in an Irish population and to examine potential associations with various patient and tumour characteristics. METHODS: A retrospective chart review of patients with cutaneous melanoma who were treated over a 10-year period was carried out. Lateral distribution of melanoma on either side of the body was compared using chi(2) analysis and evaluated by gender, age group, anatomic location, histologic subtype and Breslow depth. RESULTS: More melanomas occurred on the left side (57%, P = 0.015), and this finding was particularly significant in females. For both genders combined, there were no statistically significant differences in laterality by age group, anatomic location, type of melanoma and Breslow depth. There were significantly more superficial spreading melanomas on the left side in both men and women. CONCLUSIONS: This study demonstrates a predominance of left-sided melanomas in Irish patients. While a number of demographic and molecular associations have been proposed, further research is required to fully explain this phenomenon.

de Blacam, C

2012-02-01

425

Role of UV irradiation in aetiopathogenesis of malignant melanoma  

International Nuclear Information System (INIS)

UV irradiation has multiple effects on skin including erythema, immunosuppression and the induction of keratinocyte-derived skin cancers and cutaneous malignant melanoma. Cutaneous malignant melanoma, which arises from damage to the melanocytes, the pigment cells of the skin, is the most lethal of the skin cancers, known for its intractability to current therapies. Cutaneous malignant melanoma is associated in epidemiological studies with sun exposure of susceptible populations, especially children. In this review, we summarize the experimental information available on the role of UV radiation in melanoma and give an overview of a new melanoma model. Neonatally irradiated with UV, HGF/SF (hepatocyte growth factor/scatter factor) transgenic mice with age develop melanoma which recapitulates the aetiology, the histopathology and molecular pathogenesis of human disease. We also describe the role of melanin in the process of skin carcinogenesis. Melanin is the basic skin pigment present also in most types of melanoma. Studies on animal models for melanoma, especially HGF/SF transgenic mice, may help not only in understanding this lethal disease but also help to prevent it. (authors)

426

Melanoma prevention: are we doing enough? A Canadian perspective  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Melanoma is the most dangerous form of skin cancer, and its incidence is increasing significantly among Canadians. In parallel with the rising incidence and morbidity, the financial burden caused by this disease will continue to increase dramatically for the government and for individuals alike. More concerted effort to raise awareness of melanoma in Canada is therefore needed.

Joshua, A. M.

2012-01-01

427

Late recurrence of malignant melanoma in the duodenum.  

Science.gov (United States)

Melanoma is a malignancy originating from melanocytes. The primary melanoma usually occurs on the skin, retina, anal canal or occasionally at other organs such as the esophagus, penis or vagina. Although melanoma represents about one-third of all metastatic lesions in the gastrointestinal tract, metastasis of melanoma to the GI tract, detected radiologically or endoscopically, is relatively rare. In most cases of malignant melanoma, recurrence and death occur within 10 years after treatment of the primary lesion. We herein report a case showing a recurrence 17 years after extirpation of primary malignant melanoma in the foot. A 65-year-old man, with a history of extirpation of a malignant melanoma in the sole of his foot 17 years before, presented with anorexia and severe anemia, and multiple duodenal tumors were pointed out with upper gastrointestinal endoscopy. Histologic examination of the endoscopic biopsy specimen revealed proliferation of large polygonal cells with distinct nucleoli, and malignant melanoma was diagnosed immunohistochemically. Further examination, including computed tomography and positron emission tomography with fluorodeoxyglucose, revealed systemic metastasis. PMID:19102354

Uchiyama, Shuichiro; Imamura, Naoya; Ohuchida, Jiro; Hiyoshi, Masahide; Nagano, Motoaki; Marutsuka, Kousuke; Akiyama, Yutaka; Chijiiwa, Kazuo

2008-01-01

428

Primary mucosal malignant melanoma of the nasopharynx: two case reports  

Directory of Open Access Journals (Sweden)

Full Text Available Primary mucosal malignant melanoma of the nasopharynx is rarely seen. This tumor grows and extends silently and its early recognition is difficult. Herein, the clinical presentations of two cases of primary mucosal malignant melanomas are reported together with the treatment results.

Mert BA?ARAN

2009-01-01

429

Malignant melanoma of the tongue following low-dose radiation  

Energy Technology Data Exchange (ETDEWEB)

A 47-year-old man had a spindly malignant melanoma of the tongue many years after low-dose radiation therapy for lichen planus. To our knowledge, only 12 melanomas of the tongue have been reported previously, and in none of these was radiation documented.

Kalemeris, G.C.; Rosenfeld, L.; Gray, G.F. Jr.; Glick, A.D.

1985-03-01

430

Malignant melanoma of the tongue following low-dose radiation  

International Nuclear Information System (INIS)

A 47-year-old man had a spindly malignant melanoma of the tongue many years after low-dose radiation therapy for lichen planus. To our knowledge, only 12 melanomas of the tongue have been reported previously, and in none of these was radiation documented

431

Uveal Melanoma in the Peripheral Choroid Masquerading as Chronic Uveitis  

Science.gov (United States)

ABSTRACT Purpose To describe a case of uveal melanoma in the peripheral choroid masquerading as chronic uveitis and to raise awareness about malignant masquerade syndromes. Case Report A 36-year-old Chinese woman presented from an outside ophthalmologist with a 6-month history of unilateral chronic uveitis unresponsive to medical therapy in the left eye. She was found to have a uveal melanoma in the retinal periphery and underwent successful enucleation of her left eye. The histopathological diagnosis confirmed the clinical diagnosis. Conclusions When uveal melanoma presents in an atypical way, the diagnosis is more difficult. This case highlights the uncommon presentations of malignant melanoma of the choroid. It provides valuable information on how peripheral uveal melanoma can present with clinical signs consistent with an anterior uveitis. PMID:25036546

Feng, Lei; Zhu, Jiang; Gao, Tao; Li, Baizhou; Yang, Yabo

2014-01-01

432

Time-resolved fluorescence lifetime for cutaneous melanoma detection  

Science.gov (United States)

Melanoma is the most aggressive skin cancer type. It is characterized by pigmented lesions with high tissue invasion and metastatic potential. The early detection of melanoma is extremely important to improve patient prognosis and survival rate, since it can progress to the deadly metastatic stage. Presently, the melanoma diagnosis is based on the clinical analysis of the macroscopic lesion characteristics such as shape, color, borders following the ABCD rules. The aim of this study is to evaluate the time-resolved fluorescence lifetime of NADH and FAD molecules to detect cutaneous melanoma in an experimental in vivo model. Forty-two lesions were analyzed and the data was classified using linear discriminant analysis, a sensitivity of 99.4%, specificity of 97.4% and accuracy of 98.4% were achieved. These results show the potential of this fluorescence spectroscopy for melanoma detection.

Pires, Layla; Nogueira, Marcelo Saito; Pratavieira, Sebastiao; Moriyama, Lilian Tan; Kurachi, Cristina

2014-01-01

433

Comparative analysis of methods of preinvasive melanoma diagnostics  

Directory of Open Access Journals (Sweden)

Full Text Available The article discusses one of the problems of oncology — skin melanoma. The research objective is to study and to compare diagnostic methods of preinvasive melanoma including fluorescence diagnosis, dermatoscopy and microwave radiometry. Materials and Methods: The survey has used dermatoscope of Heine Delta 20 Company, the unit RTM-01-RES and the instrument of fluorescent diagnostics «Spectrum-Cluster.» The results suggest the possibility of early detection of melanoma with the use of dermatoscopy. The method may be applied to radiometry screening study. Fluorescence diagnostics is effective for the differential diagnosis of melanoma and melanocytic nevi. In conclusion it has been proved the need for an integrated approach to the diagnostics of melanoma of skin, depending on the different clinical situations.

Kozlov S.V.

2013-03-01

434

Multi-institute study finds uncommon BRAF melanoma mutation  

Science.gov (United States)

An uncommon mutation of the BRAF gene in melanoma patients has been found to respond to MEK inhibitor drugs, providing a rationale for routine screening and therapy in melanoma patients who harbor the BRAF L597 mutation. Mutations in BRAF V600E or KIT are common in about 40 percent to 50 percent of melanomas, and drugs that block or inhibit BRAF V600E were recently approved for treatment of melanoma patients with these mutations. However, there has been no effective treatment for patients with wildtype (WT) melanoma that is negative for these driver mutations. This study included researchers from the Vanderbilt-Ingram Cancer Center, UCLA Jonsson Comprehensive Cancer Center, and Memorial Sloan-Kettering Cancer Center.

435

Oral malignant melanoma with osteoid formation in a dog.  

Science.gov (United States)

Melanomas are the most frequent malignant neoplasms of the oral cavity of dogs. Osteogenic melanoma is a rare variant of melanoma that has been described in humans but not in animals. We describe a case of malignant melanoma with bone production affecting the gingiva of a 12-year-old Miniature Dachshund dog. The tumor was a round, lightly pigmented mass that measured 1 cm in diameter and was hard to cut. Histologically, the tumor was composed of nests and lobules of anaplastic, round, melanin-containing cells supported by a stroma displaying abundant osteoid matrix. Many of the neoplastic melanocytic cells were in close contact with the osteoid trabeculae. Immunohistochemical tests revealed that the neoplastic cells were immunoreactive for S-100 and vimentin and showed no staining with cytokeratin. The animal had a local recurrence of the tumor 3 months after the initial excision. This is the first case of malignant melanoma with osteoid formation reported in animals. PMID:9921760

Chénier, S; Doré, M

1999-01-01

436

Radiotherapy of primary human melanomas - experiences and suggestions  

Energy Technology Data Exchange (ETDEWEB)

We treated 60 invasive primary human melanomas by soft X-rays. In 23 additional cases radiotherapy was applied after total excision of a primary melanoma. Only in two cases was a tumor observed in the field of irradiation during the follow-up period: A recurrence of a primary melanoma and a skin metastasis. Radioresistance cannot be unequivocally assumed in either case. Since deeply situated in-transit metastases cannot be destroyed by soft X-rays in spite of our good results we regard radiotherapy of invasive primary melanomas as a second choice treatment to be administered if impaired general health, excessive tumor growth in certain localisations or refusal of the patient to not allow a major operation. Nodular parts of primary