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1

Cerebellar malignant fibrous histiocytoma.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma (MFH) is uncommon within the central nervous system. MFH is a malignant tumor composed of a mixture of fibroblastic and histiocytic cells, and is also known as pleomorphic fibrous xanthoma, malignant fibrous xanthoma, and pleomorphic fibrous histiocytoma. It is a pleomorphic sarcoma originally found in soft tissue and there are few reported cases within the central nervous system, in particular the cerebellum. To the best of my knowledge, this is third case arising from the cerebellum. This tumor is difficult to diagnose and may be difficult to treat.

Gelincik I

2012-07-01

2

Intraperitoneal malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Two cases of liver metastasis detected in the follow-up of intraperitoneal malignant fibrous histiocytoma (MFH) are reported. Both patients were studied by ultrasonography (US) and computerized tomography (CT), accompanied in the follow-up study by magnetic resonance. (Author)

1995-01-01

3

Postirradiation malignant fibrous histiocytoma  

Energy Technology Data Exchange (ETDEWEB)

Three patients who were treated successfully with postoperative external radiation therapy for ovarian carcinoma, endometrial adenocarcinoma, and bilateral retinoblastoma respectively developed years later malignant fibrous histiocytoma (MFH) within the irradiated field. MFH is a recently described soft tissue sarcoma known for its dual fibroblastic and histiocytic differentiation resulting in a pleomorphic histologic appearance.

Tewfik, H.H.; Tewfik, F.A.; Latourette, H.B.

1981-02-01

4

Postirradiation malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Three patients who were treated successfully with postoperative external radiation therapy for ovarian carcinoma, endometrial adenocarcinoma, and bilateral retinoblastoma respectively developed years later malignant fibrous histiocytoma (MFH) within the irradiated field. MFH is a recently described soft tissue sarcoma known for its dual fibroblastic and histiocytic differentiation resulting in a pleomorphic histologic appearance

1981-01-01

5

Calvarial malignant fibrous histiocytoma  

Directory of Open Access Journals (Sweden)

Full Text Available Primary malignant fibrous histiocytoma (MFH) of the central nervous system (CNS) is uncommon. We report cases of two young patients of MFH arising from the cranial meninges and involving the adjacent skull and scalp. There was infiltration of the brain in one case. Both the lesions were excised and primary scalp repair was performed.

Chhabra R; Gupta S; Manjunath Prasad K; Gupta D; Vasishta R; Sharma R; Khosla V

2004-01-01

6

[Intrascrotal malignant fibrous histiocytoma  

UK PubMed Central (United Kingdom)

OBJECTIVE: To describe a rare case of intrascrotal malignant fibrous histiocytoma. METHODS: A 90-year-old man presented with a scrotal mass which he had noted during the past few months. A scrotal tumor, 8 cm in diameter, was detected on physical evaluation. Tumor resection was decided due to the patient's good general condition despite his age. RESULTS: The histological analysis confirmed a sarcomatoid neoplasm with pleomorphism. The immunohistochemical analysis demonstrated strong overexpression of vimentin, alpha-1-antichymotrypsin, CD68 (Kpl), p53 oncoprotein and elevated Ki67. The ultrastructural study showed undifferentiated mesenchymal cells. The diagnosis of intrascrotal malignant fibrous histiocytoma was made based on the foregoing findings. CONCLUSIONS: Malignant fibrous histicytoma should be included in the differential diagnosis of intrascrotal tumors. Histological, immunohistochemical and ultrastructural studies are very important to distinguish the different paratesticular sarcomas. The strong overexpression of the p53 oncoprotein may be involved in the pathogenesis of this tumor type.

Medina Pérez M; Valero Puerta J; Valpuesta Fernández I; Pérez Martín D

1999-05-01

7

Postirradiation malignant fibrous histiocytoma  

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A slowly growing, firm, asymptomatic tumor developed in the skin overlying the left scapula of a 72-year-old woman during a six-month period. Twenty-seven years earlier, she had radiation treatment to that site for an intraductal carcinoma of the left breast. The histopathologic diagnosis was malignant fibrous histiocytoma (MFH). The rarity of this late complication of radiation therapy is reflected by a few reports in the medical literature of cutaneous MFH as late radiation sequelae.

Goette, D.K.; Deffer, T.A.

1985-04-01

8

Postirradiation malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

A slowly growing, firm, asymptomatic tumor developed in the skin overlying the left scapula of a 72-year-old woman during a six-month period. Twenty-seven years earlier, she had radiation treatment to that site for an intraductal carcinoma of the left breast. The histopathologic diagnosis was malignant fibrous histiocytoma (MFH). The rarity of this late complication of radiation therapy is reflected by a few reports in the medical literature of cutaneous MFH as late radiation sequelae

1985-01-01

9

Malignant fibrous histiocytoma.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma (MFH) is a type of histiocytoma and is the most common soft tissue sarcoma of late adult life. However, it is relatively uncommon in the head and neck area. It usually occurs/develops in the lower extremities and in the retroperitonium. This tumour is difficult to distinguish histologically from other sarcomas and carcinomas. Surgery is the only treatment option. Prognosis is fairly poor; recurrence and local metastasis are common. In comparison with MFH of the extremities and the trunk, the 5-year survival rate for cases of this tumour in the head and neck is low. It is important to consider MFH in differential diagnosis of head and neck tumours because of its poor prognosis. We report a rare case of MFH in an 11-year-old girl.

Mohan RP; Verma S; Siddhu VK; Agarwal N

2013-01-01

10

Postirradiation malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

An 80-year-old Japanese woman presented a severely painful tumor on the right side of the neck. The area had been treated with radiation under a diagnosis of lymphadenitis colli tuberculosa 50 years before and then with radiation for swelling on the same site (details of the condition and the dosage of radiation were not available) for a period of one year 15 years previously. A diagnosis of postirradiation malignant fibrous histiocytoma was made. Surgery and cryosurgery were not effective and the patient died about 6 months later. A review of 25 cases of postirradiation sarcoma was made. (author)

1981-01-01

11

Primary malignant fibrous histiocytoma of the pleura.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma, a type of sarcoma, is a malignant neoplasm with uncertain origin that arises in both the soft tissues and the bone. The occurrence of primary malignant fibrous histiocytoma of the pleura is extremely rare. We report a case of a 65-year-old Korean man who is being diagnosed with primary malignant fibrous histiocytoma of the pleura.

Cho KH; Park C; Hwang KE; Hwang YR; Seol CH; Choi KH; Lee MK; Choi SH; Kim HR; Jeong ET

2013-05-01

12

Primary malignant fibrous histiocytoma of the pleura.  

Science.gov (United States)

Malignant fibrous histiocytoma, a type of sarcoma, is a malignant neoplasm with uncertain origin that arises in both the soft tissues and the bone. The occurrence of primary malignant fibrous histiocytoma of the pleura is extremely rare. We report a case of a 65-year-old Korean man who is being diagnosed with primary malignant fibrous histiocytoma of the pleura. PMID:23750170

Cho, Kyung-Hwa; Park, Chul; Hwang, Ki-Eun; Hwang, Yu-Ri; Seol, Chang-Hwan; Choi, Keum-Ha; Lee, Mi-Kyung; Choi, Soon-Ho; Kim, Hak-Ryul; Jeong, Eun-Taik

2013-05-31

13

Malignant fibrous histiocytoma of bone  

International Nuclear Information System (INIS)

This is the case history of a 19-year old patient in whom a malignant tumour was found 8 years after radiotherapy of Hodgkin's disease. After some classification difficulties the tumour, which was located in the radiation-exposed proximal region of the humerus, was identified as a malignant fibrous histiocytoma. (orig./AJ)

1977-01-01

14

Fibrous histiocytoma: benign and malignant variants.  

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Twenty cases of benign and malignant fibrous histiocytoma are presented. Six were benign, 11 malignant fibrous, and 3 pure malignant histiocytomas. These tumours arise from tissue histiocytes and have a wide range of histological appearances. The characteristic histological features are described an...

Barsoum, M. S.; Eissa, S. S.; Mansour, M. A.

15

Malignant fibrous histiocytoma of the soft tissues  

International Nuclear Information System (INIS)

Malignant fibrous histiocytomas are uncommon tumors which are frequently indistinguishable from many other diseases. The authors report two cases of a malignant fibrous histiocytoma of soft tissues, one originated at the retroperitoneum and another at the thigh. They discuss the differential diagnosis and the role of radiologic methods in its diagnosis. (author)

1991-01-01

16

Malignant fibrous histiocytoma of the mediastinum.  

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A case of malignant fibrous histiocytoma of the mediastinum presenting with unusual features of fever and leucocytosis is reported. This is the youngest patient reported in the literature who had this tumour in the mediastinum.

Aggarwal, P.; Sharma, S. K.; Dey, A. B.; Chattopadhyay, T. K.; Mathur, M.

17

Osteosarcoma/Malignant Fibrous Histiocytoma of Bone (PDQ): Treatment  

Science.gov (United States)

General Information About Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Osteosarcoma and malignant fibrous histiocytoma (MFH) of the bone are diseases in which malignant (cancer) cells form in bone. Osteosarcoma ...

18

A study the malignant fibrous histiocytoma  

Energy Technology Data Exchange (ETDEWEB)

Malignant fibrous histiocytoma (MFH) is relatively rare in the oro-maxillofacial region, particularly in the oral cavity. MFH usually arise in the extremities, the thigh being the most common site. The incidence of malignant fibrous histiocytoma in bones is rather low compared with that in soft tissues. MFH is predominant tn the 40s and 50s. Histologically, the lesion are said to show high cellularity with fibrous stroma, cellular and nuclear pleomorphism, an admixture of fibroblast-like spindle cells which tend to be arranged in whorls or cartwheel or storiform patterns, rounded mononuclear cells and multinucleated giant cells. The cells frequently have abundant eosinophilic cytoplasm which has a foamy or vesicular appearance. Treatment consists of varying combinations of radiation therapy, chemotherapy, and surgery. We have observed a case of malignant fibrous histiocytoma occurred in the right maxilla of 32-year-old woman.

Kim, Young Jin; Oh, Phill Gyo; Choi, Eui Hwan [Dept. of Dentomaxillofacial Radiology, College of Dentistry, Chosun National University, Kwangju (Korea, Republic of)

1994-08-15

19

A study the malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma (MFH) is relatively rare in the oro-maxillofacial region, particularly in the oral cavity. MFH usually arise in the extremities, the thigh being the most common site. The incidence of malignant fibrous histiocytoma in bones is rather low compared with that in soft tissues. MFH is predominant tn the 40s and 50s. Histologically, the lesion are said to show high cellularity with fibrous stroma, cellular and nuclear pleomorphism, an admixture of fibroblast-like spindle cells which tend to be arranged in whorls or cartwheel or storiform patterns, rounded mononuclear cells and multinucleated giant cells. The cells frequently have abundant eosinophilic cytoplasm which has a foamy or vesicular appearance. Treatment consists of varying combinations of radiation therapy, chemotherapy, and surgery. We have observed a case of malignant fibrous histiocytoma occurred in the right maxilla of 32-year-old woman.

1994-01-01

20

Radiation-induced intracranial malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

An autopsy case of radiation-induced intracranial malignant fibrous histiocytoma (fibroxanthosarcoma) is reported. The tumor developed in the region of the sella turcica 11 years after high dose radiotherapy of a chromophobe adenoma of the pituitary. The tumor had infiltrated the base of the brain as well as the base of the skull. Metastases were not found. The tumor was composed of an admixture of bizarre fibroblasts, histiocytes and giant cells, xanthoma cells and siderophages, with a storiform fibrous stroma. This appears to be the first documented instance of a malignant fibrous histiocytoma occurring intracranially after local x irradiation

1976-01-01

 
 
 
 
21

Neutrophil chemotactic factors produced by malignant fibrous histiocytoma cell lines.  

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The clinicopathological features of malignant cells are sometimes modified by autologous cytokine production. Inflammatory fibrous histiocytoma (IFH) is characterised by leukocyte infiltration and is a variant of malignant fibrous histiocytoma (MFH). We demonstrated that three MFH cell lines (MF-1, ...

Yoshida, M.; Matsuzaki, H.; Hata, H.; Matsuno, F.; Takeya, M.; Okabe, H.; Takatsuki, K.

22

Intracardiac malignant fibrous histiocytoma. A case report.  

UK PubMed Central (United Kingdom)

BACKGROUND: Primary cardiac tumors are rare forms of cardiac disease. The reported incidence varies between 0.002 and 0.3%; 25% of these tumors are malignant, usually a variant of sarcoma. Malignant fibrous histiocytoma constitutes <3% of primary cardiac tumors. CLINICAL CASE: We review the case of a 53-year-old female who presented with congestive heart failure and pleural effusion. Transthoracic echocardiography and chest computed tomography revealed cardiac tumor involving the left atrium. Tumor was excised surgically and histologically proven to be a malignant fibrous histiocytoma, primarily confined to the heart. During the immediate postoperative evolution, the patient presented left pleural effusion for 2 weeks. The patient was referred to Oncology Service for complementary treatment. CONCLUSION: Malignant fibrous histiocytoma is a rare tumor and, in this case, prognosis is reserved.

Urías-Báez R; de la Cerda-Belmont G; Cuevas-Domínguez A; Careaga-Reyna G

2012-03-01

23

Malignant fibrous histiocytoma with skeletal involvement  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant fibrous histiocytoma of soft part is rather common but malignant fibrous histiocytoma of the bone is rarely encountered clinically. Authors present five cases of malignant fibrous histiocytoma with skeletal involvement and discuss their clinical course, x-ray findings and histological features. This tumor has marked tendency for local recurrence and metastasis. Other bone tumors such as giant cell tumor, aneurysmal bone cyst, non ossifying fibroma, osteosarcoma, fibrosarcoma of bone and metastatic cancer can be excluded by several characteristic findings observed in x-rays as well as histopathological features. All information on the patient should be carefully analysed, because it is difficult to decide whether bone involvement is primary or secondary. Four out of five cases definitely originated within the bone.

Takechi,Hideo; Taguchi,Kohji

1978-01-01

24

Malignant fibrous histiocytoma of soft tissue  

International Nuclear Information System (INIS)

Computed tomography was performed in 27 patients with confirmed malignant fibrous histiocytoma of the soft tissue. Compared with the CT results obtained in other tumours of the soft tissues, CT accuracy in malignant fibrous histiocytoma was only 74%. Non-typical attenuation values, diffuse tumour growth and non-typical contrast enhancement are discussed as reasons for the diagnostic understaging or overstaging of these soft tissue tumours. A higher accuracy was found on ultrasound examination with regard to tumour extension. Bone destruction was better visualised by CT. A base-line CT is recommended postoperatively for the earlier detection of recurrent tumours in further investigations. (orig.)

1988-01-01

25

Malignant Fibrous Histiocytoma in the Infratemporal Fossa  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in late adult life, but its incidence in oral and maxillofacial region is extremely rare. We report a case of malignant fibrous histiocytoma which occurred in the infratemporal fossa. Conventional radiograph of this case showed an ill-defined radiolucent lesion in the alveolar bone of the right maxillary first molar area, the lateral wall of the maxillary sinus, and the ascending ramus of mandible. MRI demonstrated well defined mass of intermediate signal intensity in T1 weighted images but T2 weighted images showed two distinctive regions of different characteristics. Infratemporal portion of the lesion was of hyperintense signal but under that region, the signal intensity decreased clearly, which might mean this case composed of two different subtypes, though it couldn't be confirmed by histopathological examination. Biopsy was taken in the only soft tissue of the maxillary posterior alveolar region and confirmed the lesion as the storiform-pleomorphic type of malignant fibrous histiocytoma. Histopathological subtype was well consistent with the relatively aggressive imaging findings of that region. We expect more detailed analysis of the nature of malignant fibrous histiocytoma with improvement of the imaging modality and the identification of the relationship between diagnostic imaging and histopathologic findings.

1999-01-01

26

Angiomatoid malignant fibrous histiocytoma of the eyelid  

Directory of Open Access Journals (Sweden)

Full Text Available A 20 year old female had an angiomatoid malignant fibrous histiocytoma of her left upper eyelid extending into the orbit, frontal and temporal regions. The tumor was excised and radiotherapy was given. Nine months follow-up did not reveal any recurrence.

Nath Rajiv; Saxena Sandeep; Agarwal Padam; Roy Satayajit

1992-01-01

27

MRI of intracranial meningeal malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

We describe the CT and MRI findings in a patient with primary intracranial meningeal malignant fibrous histiocytoma (MFH). CT delineated the anatomical relations and MRI aided in tissue characterisation. To our knowledge, this is the first report describing the MRI findings in primary intracranial meningeal MFH. (orig.). With 1 fig

1996-01-01

28

Postirradiation malignant fibrous histiocytoma of the trachea  

International Nuclear Information System (INIS)

A 77-yr-old woman presented with a malignant fibrous histiocytoma (MFH) of the trachea 11 yr after right subtotal thyroidectomy and delivery of 5400 rads to the neck for infiltrating papillary thyroid carcinoma. The tumor developed in the irradiated area. Postirradiation MFH tends to occur in subcutaneous tissues, and is rare in lung parenchyma or airways

1987-01-01

29

Malignant Fibrous Histiocytoma Arising from Nasal Cavity  

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The present aim is to report a case of malignant fibrous histiocytoma of the nasal cavity in a 64-year-old woman. This is a rare entity in the head and neck region. The patient referred with nasal obstruction and underwent wide surgical resection with negative margin. He is well with no evidence...

Mohammad Ali Damghani; Mohammad Hasan Larizadeh

30

Postirradiation malignant fibrous histiocytoma of the trachea  

Energy Technology Data Exchange (ETDEWEB)

A 77-yr-old woman presented with a malignant fibrous histiocytoma (MFH) of the trachea 11 yr after right subtotal thyroidectomy and delivery of 5400 rads to the neck for infiltrating papillary thyroid carcinoma. The tumor developed in the irradiated area. Postirradiation MFH tends to occur in subcutaneous tissues, and is rare in lung parenchyma or airways.

Louie, S.; Cross, C.E.; Amott, T.R.; Cardiff, R.

1987-03-01

31

Malignant fibrous histiocytoma of the bone (radiodiagnosis)  

International Nuclear Information System (INIS)

Clinical and X-ray signs of malignant fibrous histiocytoma of the bone were described on the basis of a literature analysis and 12 observations. From the roentgenological view-point various tumor symptoms can fall into 2 types and 2 variants

1985-01-01

32

Malignant Fibrous Histiocytoma of Chest Wall  

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Primary malignant fibrous histiocytoma (MFH) of the chest wall is rare. We report a case of primary MFH arising from the chest wall, which was thought to be a metastasis or myeloma. The imaging study revealed a single mass of the chest wall involving a rib. Resection and chest wall reconstruction wa...

An, Jin-Kyung; Oh, Ki Keun

33

Malignant Fibrous Histiocytoma Arising from Nasal Cavity  

Directory of Open Access Journals (Sweden)

Full Text Available The present aim is to report a case of malignant fibrous histiocytoma of the nasal cavity in a 64-year-old woman. This is a rare entity in the head and neck region. The patient referred with nasal obstruction and underwent wide surgical resection with negative margin. He is well with no evidence of disease for 36 months after surgery.

Mohammad Ali Damghani; Mohammad Hasan Larizadeh

2008-01-01

34

Malignant Fibrous Histiocytoma in the Infratemporal Fossa  

Energy Technology Data Exchange (ETDEWEB)

Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in late adult life, but its incidence in oral and maxillofacial region is extremely rare. We report a case of malignant fibrous histiocytoma which occurred in the infratemporal fossa. Conventional radiograph of this case showed an ill-defined radiolucent lesion in the alveolar bone of the right maxillary first molar area, the lateral wall of the maxillary sinus, and the ascending ramus of mandible. MRI demonstrated well defined mass of intermediate signal intensity in T1 weighted images but T2 weighted images showed two distinctive regions of different characteristics. Infratemporal portion of the lesion was of hyperintense signal but under that region, the signal intensity decreased clearly, which might mean this case composed of two different subtypes, though it couldn't be confirmed by histopathological examination. Biopsy was taken in the only soft tissue of the maxillary posterior alveolar region and confirmed the lesion as the storiform-pleomorphic type of malignant fibrous histiocytoma. Histopathological subtype was well consistent with the relatively aggressive imaging findings of that region. We expect more detailed analysis of the nature of malignant fibrous histiocytoma with improvement of the imaging modality and the identification of the relationship between diagnostic imaging and histopathologic findings.

Lee, Kyung Hee; Heo, Min Suk; Lee, Sam Sun; Choi, Soon Chul [Dept. of Oral and Maxillofacial Radiology and Dental Research Institute, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

1999-08-15

35

MRI of intracranial meningeal malignant fibrous histiocytoma  

Energy Technology Data Exchange (ETDEWEB)

We describe the CT and MRI findings in a patient with primary intracranial meningeal malignant fibrous histiocytoma (MFH). CT delineated the anatomical relations and MRI aided in tissue characterisation. To our knowledge, this is the first report describing the MRI findings in primary intracranial meningeal MFH. (orig.). With 1 fig.

Ogino, A. [Department of Radiology, Nagasaki University School of Medicine (Japan); Ochi, M. [Department of Radiology, Nagasaki University School of Medicine (Japan); Hayashi, K. [Department of Radiology, Nagasaki University School of Medicine (Japan); Hirata, K. [Department of Neurosurgery, Nagasaki University School of Medicine (Japan); Hayashi, T. [Department of Pathology, Nagasaki University School of Medicine (Japan); Yasunaga, A. [Department of Neurosurgery, Nagasaki University School of Medicine (Japan); Shibata, S. [Department of Neurosurgery, Nagasaki University School of Medicine (Japan)

1996-11-01

36

Malignant fibrous histiocytoma of soft tissue  

Energy Technology Data Exchange (ETDEWEB)

Four cases of malignant fibrous histiocytomas are reported. An attempt is made to determine some characteristic roentgenologic features of this disease. There is no pathognomonic radiologic sign; however, angiographic documentation of hypervascularisation together with neovascularity and absorption values of about 35 HE in computed tomography suggest a predominantly fibrous sarcoma. Differential diagnosis on abscess formation, tumours of the fat tissue and primary vascular neoplasm should be performed and these conditions ruled out if not applicable.

Friedburg, H.; Wimmer, B.; Adler, C.P.; Gospos, C.; Salm, R.

1982-10-01

37

Malignant fibrous histiocytoma of the orbit  

Directory of Open Access Journals (Sweden)

Full Text Available Two cases of malignant fibrous histiocytoma of the orbit are reported. Histopathological examination of the orbital biopsy specimen obtained after orbitotomy in one case and exenteration in another showed pleomorphic neoplastic cells arranged in storiform pattern. The tumour cells were composed of hyperchromatic nuclei with prominent nucleoli and admixtures of fibrob-lasts. Postoperative radiotherapy and chemotherapy were given. There was no evidence of recurrence two years later.

Betharia S; Arora Roopa; Kumar Sushil

1988-01-01

38

Postirradiation sarcoma (malignant fibrous histiocytoma) of axilla  

International Nuclear Information System (INIS)

A case is reported of a patient who developed a histologically unusual sarcoma in the axilla and chest wall 8 years after receiving radiation therapy (6500 rad) for carcinoma of the breast. This sarcoma showed light- and electron-microscopic features of a malignant fibrous histiocytoma, a tumor not documented among 24 previously reported cases of postirradiation sarcoma following the diagnosis of breast carcinoma. In addition, the literature is reviewed and discussed regarding postirradiation sarcoma in general following breast carcinoma

1978-01-01

39

Hepatic malignant fibrous histiocytoma of imaging characteristics  

International Nuclear Information System (INIS)

Objective: To enhance the understanding of imaging characteristics of hepatic malignant fibrous histiocytoma. Methods: Four cases of hepatic malignant fibrous histiocytoma proven by pathology were examined by means of CT (n=4), MRI (n=2), and angiography (n=1). Results: All tumors of the four patients were located in the right lobe of the liver. The marginal contours were irregular. The tumors extended to the liver capsule in three patients. On CT, all tumors were hypodense (28-36 HU) on plain scan compared with surrounding liver parenchyma. Plaque-like slight hyper dentisites were seen in two patients. After contrast injection, the solid portion of the mass showed mild enhancement (52-70 HU) in arterial phase, and moderate enhancement in venous phase (75-98 HU). Obvious nonenhanced necrotic areas were seen in all cases. On MR images, the main signal intensity of the mass was hypointense on T1-weighted imaging compared with the adjacent liver. Plaque-like hyper intensities were seen in one patients. The intensity of the masses were higher than that of the liver on T2-weighted images. Angiography of one patient showed displacement of hepatic vasculature by the mass on arterial phase and irregular tumor staining was seen on parenchyma phase. Conclusion: The primary imaging character of hepatic malignant fibrous histiocytoma is apparently invasive with unclear border and massive necrosis in the central part, and intratumoral bleeding is common. (authors)

2005-01-01

40

Postirradiation sarcoma (malignant fibrous histiocytoma) following cervix cancer  

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A case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 11 years following postoperative external beam radiation therapy (7000 rad) for carcinoma of the cervix. Reports of postirradiation malignant fibrous histiocytoma are rare, and the occurrence of this neoplasm following treatment of cervix cancer has not previously been described. The literature concerning postirradiation bone and soft tissue sarcomas is briefly reviewed, with special attention to malignant fibrous histiocytomas.

Pinkston, J.A.; Sekine, I.

1982-02-01

 
 
 
 
41

Postirradiation sarcoma (malignant fibrous histiocytoma) following cervix cancer  

International Nuclear Information System (INIS)

A case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 11 years following postoperative external beam radiation therapy (7000 rad) for carcinoma of the cervix. Reports of postirradiation malignant fibrous histiocytoma are rare, and the occurrence of this neoplasm following treatment of cervix cancer has not previously been described. The literature concerning postirradiation bone and soft tissue sarcomas is briefly reviewed, with special attention to malignant fibrous histiocytomas

1982-02-01

42

Postirradiation sarcoma (malignant fibrous histiocytoma) following cervix cancer  

International Nuclear Information System (INIS)

[en] A case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 11 years following postoperative external beam radiation therapy (7,000 rad) for carcinoma of the cervix. Reports of postirradiation malignant fibrous histiocytoma are rare, and the occurrence of this neoplasm following treatment for cervix cancer has not previously been described. The literature concerning postirradiation bone and soft tissue sarcomas is briefly reviewed, with special attention to malignant fibrous histiocytomas. (author)

1980-01-01

43

Skeletal manifestations of primary malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Sixty-five patients, aged 18-84 years, with pathologically proved primary malignant fibrous histiocytoma of bone were studied. Tumors were distributed equally between men and women. The plain film, CT, bone scan, and angiographic findings in each patient were reviewed and correlated. The lesions were predominantly in the appendicular skeleton (66%), with about 33% being centrally located. Only one patient had multiple skeletal lesions. Fifty-two percent of the lesions were lytic, 28% were blastic, and 20% had a mixed pattern. This lesion should be recognized by the radiologist as an entity which has a poor prognosis

1986-12-05

44

Gallium scanning in malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma (MFH) is a recently defined, well established clinical and pathologic entity. Five patients with MFH who had gallium-67 scans are described. An attempt is made to correlate the presence, abscence, and extent of disease, as both primary and metastatic deposits showed avidity for gallium-67. After excision, patients with negative gallium scans were well, while metastatic disease was shown by gallium scans in two patients shortly before death. Gallium scanning is advocated for initial evaluation and follow-up of patients with MFH

1980-01-01

45

Gallium scanning in malignant fibrous histiocytoma  

Energy Technology Data Exchange (ETDEWEB)

Malignant fibrous histiocytoma (MFH) is a recently defined, well established clinical and pathologic entity. Five patients with MFH who had gallium-67 scans are described. An attempt is made to correlate the presence, abscence, and extent of disease, as both primary and metastatic deposits showed avidity for gallium-67. After excision, patients with negative gallium scans were well, while metastatic disease was shown by gallium scans in two patients shortly before death. Gallium scanning is advocated for initial evaluation and follow-up of patients with MFH.

Zazzaro, P.F.; Bosworth, J.E.; Schneider, V.; Zelenak, J.J.

1980-10-01

46

Cardiac metastasis in malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma MFH is an aggressive spindle cell cancer and is the most common soft tissue tumor in the elderly, primary affecting the extremities. It has the high metastatic potential and can spread to various viscera including liver, lung, bone and brain; however, cardiac metastasis is an extreme rarity. Here, present a 50-year-old male, diagnosed as pleiomorphic storiform MFH of a right arm who developed parenchymal pulmonary metastases and a mass lesion in left atrium. Patient had a downhill course and eventually succumbed. (author)

2008-01-01

47

Radiation-induced malignant fibrous histiocytoma  

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Among adult malignant tumors of soft tissue, malignant fibrous histiocytoma (MFH) is the most common type. Its prognosis is poor. We have encountered a case of radiation-induced MFH occurring 8 years after radiotherapy (4500 rad to total pelvis, radium needle: 10 mCiX 2 to intra-vagina) for uterine cervical cancer (IIb). Tumor was located in the retroperitoneum of the right fossa iliaca and resected with a part of musculus iliopsoas. Microscopically, two cell pattern contained a greater number of large, bizarre histiocytic cells and plumper fibroblastic cells. Specimen did not show storiform pattern clearly, but was positive for {alpha}1-antichymotrypsin, {alpha}1-antitrypsin and vimentin by immunofluorescence staining. Electron microscopy revealed multinucleated giant cells with a moderate amount of rough endoplasmic reticulum in the cytoplasm. This case had a history of radiation therapy, occurence of second tumor in the radiation field, second tumor occurring over the 2 years latent periods after radiation, and second tumor with different histological findings. This case represents radiation induced malignant fibrous histiocytoma. (author).

Takahashi, Tsukasa; Hasumi, Kenichiro (Hijirigaoka Hospital, Kochi (Japan)); Kosaki, Kouichi; Fujii, Yuzo

1991-07-01

48

Radiation-induced malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Among adult malignant tumors of soft tissue, malignant fibrous histiocytoma (MFH) is the most common type. Its prognosis is poor. We have encountered a case of radiation-induced MFH occurring 8 years after radiotherapy (4500 rad to total pelvis, radium needle: 10 mCiX 2 to intra-vagina) for uterine cervical cancer (IIb). Tumor was located in the retroperitoneum of the right fossa iliaca and resected with a part of musculus iliopsoas. Microscopically, two cell pattern contained a greater number of large, bizarre histiocytic cells and plumper fibroblastic cells. Specimen did not show storiform pattern clearly, but was positive for ?1-antichymotrypsin, ?1-antitrypsin and vimentin by immunofluorescence staining. Electron microscopy revealed multinucleated giant cells with a moderate amount of rough endoplasmic reticulum in the cytoplasm. This case had a history of radiation therapy, occurence of second tumor in the radiation field, second tumor occurring over the 2 years latent periods after radiation, and second tumor with different histological findings. This case represents radiation induced malignant fibrous histiocytoma. (author)

1991-01-01

49

Imaging of soft tissue malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma (MFH) is a rare and potentially highly malignant sarcoma. The authors report 6 cases of MFH in various sites : two in the chest wall, one in the pelvis, two in the gluteal zones and one on the scalp. Ultrasonography and computed tomography were the main imaging methods used in the assessment of the structure and extension of the tumor. A poor prognosis was noted in four cases: death within a few months in the two thoracic sites, recurrence in the pelvic and scalp lesions, radical surgery allowed recovery in two cases. A review of the literature showed that MRI and CT are complementary in the initial staging and follow-up these patients. (author)

1996-01-01

50

A postirradiation, myxoid type, malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

The authors discuss the case of a 59-year-old man who presented a mass in the dorsum of his right foot. He previously had had a hemangioma in this region from birth, and at the age of 10, radiation therapy had been administered to this region because of an ulcer that had developed. Additionally, so as to cover the ulcer, he had been given a free skin graft and a cross-leg flap. Some 50 years after this radiation, he noticed a mass in his foot, and a microscopic examination of a biopsied specimen of this mass revealed it to be a myxoid type, malignant fibrous histiocytoma (MFH). Thus, a below-the-knee amputation was performed. To the best of their knowledge, the authors report that 29 cases of an MFH developing after radiotherapy have been reported in the Japanese literature, and an analysis of these 29 cases is provided and the details of this case are given. (author)

1993-01-01

51

Malignant fibrous histiocytoma of the gingiva.  

Science.gov (United States)

Malignant fibrous histiocytoma (MFH) is widely regarded as the commonest soft tissue sarcoma of adulthood which tends to occur in the deep soft tissues of the extremities and the retroperitoneum. Uncertain histogenesis and numerous subtypes make MFH a rather controversial entity. These tumours are relatively rare in the head and neck region accounting for only 1-3% of all cases of MFH. MFH exhibits a heterogenous histology of spindle cells in a characteristic storiform pattern with pleomorphic tumour cells and giant cells. A case is reported of an MFH of the gingiva in a 60-year-old woman who presented with a painful swelling originating from the left maxillary gingiva. The clinical, histopathological and immunohistochemical findings are discussed. PMID:23257940

Vijayalakshmi, D; Fathima, Shabana; Ramakrishnan, K; Devi, M

2012-12-19

52

Postirradiation Sarcoma (Malignant Fibrous Histiocytoma) Following Cervix Cancer.  

Science.gov (United States)

A case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 11 years following postoperative external beam radiation therapy (7,000 rad) for carcinoma of the cervix. Reports of postirradiati...

J. A. Pinkston I. Sekine

1980-01-01

53

Malignant fibrous histiocytoma: vascular invasion and metastasis to heart  

International Nuclear Information System (INIS)

Two cases of biopsy-proven malignant fibrous histiocytoma are presented which showed local as well as vascular spread resulting in cardiac metastasis and peri-and postoperative complications leaving palliative surgery as the prime management. (author)

2003-01-01

54

Recurrent malignant fibrous histiocytoma in psoas muscle: a case report.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma is one of the most common sarcomas that occur in soft tissue, it usually develops in old age individuals and the incidence is similar between the genders. We report here on a case with invasive local recurrence after surgical resection of a malignant fibrous histiocytoma that occurred in the left psoas muscle of a 69-year-old male patient. The patient was first admitted to our hospital with a primary lesion in the left lower abdomen, as seen on magnetic resonance imaging. We report here on a rare case of a malignant fibrous histicytoma in the psoas muscle.

Ko SH; Cha JR; Lee KJ

2012-09-01

55

Nuclear magnetic resonance studies on malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

The relaxation times of water protons in the tissues of malignant fibrous histiocytoma (MFH) and the tumor treated with adriamycin (adriamycin-treated MFH) were studied in rats as a model of human MFH by nuclear magnetic resonance. Using the values of the malignancy index derived from the relaxation times of these tumors, it has been possible to discriminate clearly between MFH tissue and non-malignant tissue, and to evaluate the effectiveness of anticancer drug. The malignancy index, furthermore, was compatible with the histological evaluation of the effectiveness of chemotherapy in an adriamycin-treated malignant fibrous histiocytoma. (author)

1987-01-01

56

The gallium scan in malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Soft tissue sarcoma is a relatively uncommon malignancy. Of its various histological types, malignant fibrous histiocytoma is most common and usually is seen in late adult life affecting primarily extremities and trunk with or without bony involvement. Before undertaking potentially toxic treatments with chemotherapeutic agents, tumor aggressiveness must be estimated. The authors use /sup 67/Ga citrate to supplement other imaging modalities to measure size, location and extent prior to and during treatment. In all, 22 consecutive patients were studied, with 13 males and 9 females. The median age was 43 (range 15 to 68) with majority of patients in 4th to 6th decades. Extremity lesions were present in 18, pelvic in 1, thoracic in 2, and abdominal in 1. Eighteen patients were studied shortly after the diagnosis and 4 during their recurrences. In the 18 patients with primary tumor, 12 showed marked increased uptake in the region of tumor, or increased uptake in soft tissues with a distribution different from the changes noted in the MDP bone scan. In 4 patients with extremity lesions, abnormalities were seen in Ga but were not definite in MDP bone scans. Four patients had tumor recurrences following surgery, radiation therapy or chemotherapy. High Ga uptake was found in the regions of recurrent tumor in 2 and in the lung metastases of another. Interval changes were more easily appreciated in the Ga scan than in the MDP bone scan. Information obtained from Ga images provides additional clues in determining extent of soft tissue involvement and assists in monitoring therapeutic responses

1984-01-01

57

[Malignant fibrous histiocytoma of the gums. Anatomo-clinical study of a case  

UK PubMed Central (United Kingdom)

A case of malignant fibrous histiocytoma occurring in the gingival tissue on the site of the mandibular right canine is reported. The histological, histochemical, immunohistochemical and ultrastructural features are discussed and compared with the recent literature on malignant fibrous histiocytomas.

Latorre G; Carrozza G; Busà S; D'Alcontres AS; Briguglio R

1989-07-01

58

Malignant fibrous histiocytoma of maxilla — a report of five cases and review of literature  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Malignant fibrous histiocytoma of the maxilla is a rare malignant tumor of the bone. Affection of maxilla does not occur very commonly. In this report five cases of fibrous histiocytoma have been presented along with a review of literature.

Panda, Naresh K.; Radotra, B. D.; Mann, S. B. S.

59

Primary malignant fibrous histiocytoma of the mesentery: a case report  

International Nuclear Information System (INIS)

A malignant fibrous histiocytoma of the mesentery is rare, and multifocal involvement as a primary tumor is very rare. In this report, a case of malignant fibrous histiocytoma of the mesentery presenting with two masses and multiple peritoneal seeding in a 48-year-old man is described. A physical examination revealed a large, firm, and non-tender mass in the right lower abdomen of the patient. Computed tomography of the lesion revealed a partially, indistinctly marginated and heterogeneously enhancing mass with irregular peritumoral strands in the mesentery of the right lower abdomen, while sonograms of the lesion revealed an ill-defined low-echoic mass. The final pathology demonstrated the presence of a storiform-pleomorphic malignant fibrous histiocytoma

2007-01-01

60

Primary malignant fibrous histiocytoma of the mesentery: a case report  

Energy Technology Data Exchange (ETDEWEB)

A malignant fibrous histiocytoma of the mesentery is rare, and multifocal involvement as a primary tumor is very rare. In this report, a case of malignant fibrous histiocytoma of the mesentery presenting with two masses and multiple peritoneal seeding in a 48-year-old man is described. A physical examination revealed a large, firm, and non-tender mass in the right lower abdomen of the patient. Computed tomography of the lesion revealed a partially, indistinctly marginated and heterogeneously enhancing mass with irregular peritumoral strands in the mesentery of the right lower abdomen, while sonograms of the lesion revealed an ill-defined low-echoic mass. The final pathology demonstrated the presence of a storiform-pleomorphic malignant fibrous histiocytoma.

Park, Jong Heon; Yeon, Jae Woo; Han, Eun Mee; Jang, Suk Ki; Kang, Su Min; Ahn, In Oak [Bundang Jesaeng General Hospital, Sungnam (Korea, Republic of)

2007-12-15

 
 
 
 
61

Primary pleomorphic malignant fibrous histiocytoma of the heart.  

Science.gov (United States)

Primary pleomorphic malignant fibrous histiocytoma of the heart is rare. The present study was performed to study the clinical and pathological features of the disease. We describe two rare cases of primary cardiac malignant fibrous histiocytoma and review the published individual data of the patients. Both patients complained of dyspnea, and underwent palliative tumor resection. However, they died several months after surgery. A thorough literature review with clinical presentations, diagnostic features, treatment, and outcomes was done. We have for the first time analyzed the factors related to the survival of malignant fibrous histiocytoma. It is usually difficult to make an appropriate preoperative diagnosis. Despite complete surgical resection and aggressive chemotherapy and radiotherapy, the prognosis is still poor. PMID:23566556

Wang, Jigang; Jiang, Yanxia; Wang, Yuewei; Yu, Wenjuan; Zhao, Peng; Li, Yujun; Lin, Dongliang; Xin, Fangjie

2013-04-06

62

Primary pleomorphic malignant fibrous histiocytoma of the heart.  

UK PubMed Central (United Kingdom)

Primary pleomorphic malignant fibrous histiocytoma of the heart is rare. The present study was performed to study the clinical and pathological features of the disease. We describe two rare cases of primary cardiac malignant fibrous histiocytoma and review the published individual data of the patients. Both patients complained of dyspnea, and underwent palliative tumor resection. However, they died several months after surgery. A thorough literature review with clinical presentations, diagnostic features, treatment, and outcomes was done. We have for the first time analyzed the factors related to the survival of malignant fibrous histiocytoma. It is usually difficult to make an appropriate preoperative diagnosis. Despite complete surgical resection and aggressive chemotherapy and radiotherapy, the prognosis is still poor.

Wang J; Jiang Y; Wang Y; Yu W; Zhao P; Li Y; Lin D; Xin F

2013-09-01

63

Malignant fibrous histiocytoma of colon: a case report  

International Nuclear Information System (INIS)

Gastrointestinal malignant fibrous histiocytomas (MFH) are very rare and only about 30 cases have been reported in the English literature, among which 20 cases were from colorectal MFHs. A small bowel MFH with intussusception has been the only reported case in the Korean medical literature. A 52-year-old male presented with complaints of recently developed and aggravated right upper abdominal pain. We present the CT appearance and the clinico-pathologic findings of his primary inflammatory malignant fibrous histiocytoma, which arose from the subserosal layer of the ascending colon with tumor infiltration in all the layers. The colon showed extensive hemorrhagic necrosis and repetitive multifocal microperforations with resultant panperitonitis

2006-01-01

64

Malignant fibrous histiocytoma of colon: a case report  

Energy Technology Data Exchange (ETDEWEB)

Gastrointestinal malignant fibrous histiocytomas (MFH) are very rare and only about 30 cases have been reported in the English literature, among which 20 cases were from colorectal MFHs. A small bowel MFH with intussusception has been the only reported case in the Korean medical literature. A 52-year-old male presented with complaints of recently developed and aggravated right upper abdominal pain. We present the CT appearance and the clinico-pathologic findings of his primary inflammatory malignant fibrous histiocytoma, which arose from the subserosal layer of the ascending colon with tumor infiltration in all the layers. The colon showed extensive hemorrhagic necrosis and repetitive multifocal microperforations with resultant panperitonitis.

Lee, Jae Hwan; Jee, Keum Nahn [Dankook University College of Medicine, Cheonan (Korea, Republic of)

2006-03-15

65

Malignant fibrous histiocytoma of maxilla following radiotherapy for bilateral retinoblastoma  

International Nuclear Information System (INIS)

A 20-year-old man developed a malignant fibrous histiocytoma in the right maxilla 19 years after irradiation for bilateral retinoblastoma. The incidence of second tumours in patients who survived bilateral retinoblastoma treated with radiation was 8.5 per cent. Malignant fibrous histiocytomas which arise in a site of prior radiation are fatal. The present case is presumed to have the autosomal dominant retinoblastoma gene, not associated with deletion of the q14 band of chromosome 13. The patient succumbed to the second tumour. (author)

1982-06-19

66

Malignant fibrous histiocytoma of maxilla following radiotherapy for bilateral retinoblastoma  

Energy Technology Data Exchange (ETDEWEB)

A 20-year-old man developed a malignant fibrous histiocytoma in the right maxilla 19 years after irradiation for bilateral retinoblastoma. The incidence of second tumours in patients who survived bilateral retinoblastoma treated with radiation was 8.5 per cent. Malignant fibrous histiocytomas which arise in a site of prior radiation are fatal. The present case is presumed to have the autosomal dominant retinoblastoma gene, not associated with deletion of the q14 band of chromosome 13. The patient succumbed to the second tumour.

Nishizawa, S.; Hayashida, T.; Horiguchi, S.; Inouye, K. (Tokyo Univ. (Japan). Faculty of Medicine); Imamura, T. (Tokyo Univ. (Japan). Branch Hospital)

1985-05-01

67

Malignant fibrous histiocytoma following radiation therapy of fibrous dysplasia: case report  

Energy Technology Data Exchange (ETDEWEB)

Malignant fibrous histiocytoma commonly occurs spontaneously. In some cases it follows previous therapeutic or incidental irradiation, or miscellaneous pre-existing osseous conditions. Recently, it has been associated with total hip arthroplasty. We report a case of malignant fibrous histocytoma following radiation therapy of fibrous dysplasia and review literature. (author).

Amin, R.; Ling, R. [Royal Devon and Exeter Hospital (United Kingdom)

1995-10-01

68

Malignant fibrous histiocytoma following radiation therapy of fibrous dysplasia: case report  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma commonly occurs spontaneously. In some cases it follows previous therapeutic or incidental irradiation, or miscellaneous pre-existing osseous conditions. Recently, it has been associated with total hip arthroplasty. We report a case of malignant fibrous histocytoma following radiation therapy of fibrous dysplasia and review literature. (author)

1995-01-01

69

Interleukin-8 Producing Malignant Fibrous Histiocytoma with Prolonged Fever  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We present a case of malignant fibrous histiocytoma accompanied by prolonged spiking fevers, which disappeared after tumor resection. Sarcoma with fever as a primary symptom is rare. Furthermore, in this case, fever was closely related to the clinical course of the tumor. In order to detect possible...

Osaka, Shunzo; Hayakawa, Satoshi; Yoshida, Yukihiro; Sakurada, Eisaku; Ryu, Junnosuke; Sugitani, Masahiko

70

Malignant fibrous histiocytoma of primary omental origin in an infant  

Energy Technology Data Exchange (ETDEWEB)

A case of malignant fibrous histiocytoma occurring in an infant is presented. The primary location of the tumor was in the omentum. Sonography showed huge, lobulated echogenic masses with cystic areas. CT demonstrated heterogeneously enhancing masses with central cystic and necrotic areas. This very unusual occurrence of a tumor in infancy with an intraabdominal location is described and the radiographic imaging is presented. (orig.)

Kim, O.H. (Dept. of Radiology, St. Mary' s Hospital, Catholic Univ. Medical Coll., Seoul (Korea, Republic of)); Lee, K.Y. (Dept. of Pathology, St. Mary' s Hospital, Catholic Univ. Medical Coll., Seoul (Korea, Republic of))

1994-08-01

71

Post-radiation cranial malignant fibrous histiocytoma studied by CT  

Energy Technology Data Exchange (ETDEWEB)

A 37-year-old woman presented with a proven case of malignant fibrous histiocytoma of the skull. This is thought to be a rare complication of post-radiation to a chromophobe adenoma which was treated by radiotherapy nine years previously. The radiation dose given to the sella region after the removal of the chromophobe adenoma was 4500 cGy.

Romero, F.J.; Ortega, A.; Ibarra, B.; Piqueras, J.; Rovira, M.

1989-03-01

72

Malignant inflammatory fibrous histiocytoma of bone and acute lymphoblastic leukaemia.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A patient is described who developed a malignant inflammatory fibrous histiocytoma of vertebral bone (MFH) 4 months after the onset of acute lymphoblastic leukaemia. This is the first report of the simultaneous occurrence of these two conditions. Similarities to the more frequent occurrence of anoth...

Woodcock, B. E.; Parsons, M. A.; Winfield, D. A.

73

Malignant fibrous histiocytoma of primary omental origin in an infant  

International Nuclear Information System (INIS)

A case of malignant fibrous histiocytoma occurring in an infant is presented. The primary location of the tumor was in the omentum. Sonography showed huge, lobulated echogenic masses with cystic areas. CT demonstrated heterogeneously enhancing masses with central cystic and necrotic areas. This very unusual occurrence of a tumor in infancy with an intraabdominal location is described and the radiographic imaging is presented. (orig.)

1994-01-01

74

Retroperitoneal malignant fibrous histiocytoma: radiological aspects - a case report  

International Nuclear Information System (INIS)

The authors present a retroperitoneal malignant fibrous histiocytoma case report that, although considered the most common soft tissue sarcoma in middle-aged adults, still represents a difficult diagnosis, rising a lot of doubt. It is emphasized the importance of computer tomography and magnetic resonance imaging in correlation with pathological aspects. (author). 6 refs, 7 figs

1995-01-01

75

Myxoid Malignant Fibrous Histiocytoma with Multiple Primary Sites  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Malignant fibrous histiocytoma (MFH) is one of the most common types of soft tissue sarcomas in adults. The most common location of MFH are the extremities and the trunk, with the most common site for distant metastases being the lung. We describe a case with multiple synchronous sites of myxoid MFH...

Muler, Jeffrey H.; Paulino, Augusto F.; Roulston, Diane; Baker, Laurence H.

76

Post-radiation cranial malignant fibrous histiocytoma studied by CT  

International Nuclear Information System (INIS)

A 37-year-old woman presented with a proven case of malignant fibrous histiocytoma of the skull. This is thought to be a rare complication of post-radiation to a chromophobe adenoma which was treated by radiotherapy nine years previously. The radiation dose given to the sella region after the removal of the chromophobe adenoma was 4500 cGy

1989-01-01

77

Malignant Fibrous Histiocytoma Arising from the Omentum Presenting as Hemoperitoneum  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Malignant fibrous histiocytoma (MFH) is an uncommon soft-tissue sarcoma that occurs primarily in the extremities and rarely involves the retroperitoneum and abdomen. A 63-year-old man was admitted to the emergency room because of epigastric pain. Computed tomography revealed a large heterogeneous en...

Kweon, Ji Hye; Choi, Chang Soo; Im, Chong Ju; Seo, Geom Seog; Choi, Suck Chei

78

A case of postirradiated malignant fibrous histiocytoma of the vagina  

International Nuclear Information System (INIS)

An unusual case of postirradiated malignant fibrous histiocytoma of the vagina in a 72-year-old female is reported. The tumor occurred in the radiation field 30 years after radical hysterectomy and preoperative radiation therapy (radium 5,200 mgh) for squamous cell carcinoma of the uterine cervix. She had been disease free for 30 years until she noticed a large mass in the vagina. Cytological study showed mainly two types of non-epithelial malignant cells; spindle-shaped fibroblast-like cells and histiocyte-like cells. Bizarre mono or multinucleated giant cells were often observed. The operative specimen revealed an arrangement composed of short or long spindle cells and vacuolated mononucleated and large multinucleated cells. The diagnosis was comfirmed by immunohistological and ultrastructural study. We have reviewed the literature on malignant fibrous histiocytoma occurring after radiation for cervical carcinoma. (author)

1992-01-01

79

A case of postirradiated malignant fibrous histiocytoma of the vagina  

Energy Technology Data Exchange (ETDEWEB)

An unusual case of postirradiated malignant fibrous histiocytoma of the vagina in a 72-year-old female is reported. The tumor occurred in the radiation field 30 years after radical hysterectomy and preoperative radiation therapy (radium 5,200 mgh) for squamous cell carcinoma of the uterine cervix. She had been disease free for 30 years until she noticed a large mass in the vagina. Cytological study showed mainly two types of non-epithelial malignant cells; spindle-shaped fibroblast-like cells and histiocyte-like cells. Bizarre mono or multinucleated giant cells were often observed. The operative specimen revealed an arrangement composed of short or long spindle cells and vacuolated mononucleated and large multinucleated cells. The diagnosis was comfirmed by immunohistological and ultrastructural study. We have reviewed the literature on malignant fibrous histiocytoma occurring after radiation for cervical carcinoma. (author).

Mori, Yasuhiro; Nei, Hideyuki; Koizumi, Motoiki; Tanaka, Satoshi; Sagae, Satoru; Mizuuchi, Hidemitsu; Ito, Eiki; Kudo, Ryuuichi (Sapporo Medical Coll. (Japan))

1992-11-01

80

Retroperitoneal Malignant Fibrous Histiocytoma Can Mimic a Hydatid Cyst  

Science.gov (United States)

Malignant fibrous histiocytoma is the second most common soft-tissue sarcoma in adults. After the extremities, the retroperitoneal space is the second most common site of this tumor. A 50-year-old man presented with a right retroperitoneal, thick-walled, cystic multilocular mass measuring 10?×?10?cm that was thought to be a type CE 5 hydatid cyst preoperatively. However, the postoperative histopathology did not agree with the radiological findings and instead showed a malignant fibrous histiocytoma. The computed tomography and ultrasound/Doppler ultrasound findings of this retroperitoneal mass mimicked a type CE 5 hydatid cyst. We present this case because the surgical management of these two lesions differs and misdiagnosis can be problematic.

Erbay, Gurcan; Ulusan, Serife; Koc, Zafer; Canpolat, Emine Tuba; Cal?skan, Kenan

2011-01-01

 
 
 
 
81

Primary malignant fibrous histiocytoma of the pleura - a radiological finding  

International Nuclear Information System (INIS)

The authors report a case of pleural malignant fibrous histiocytoma with lung invasion in a 31-year-old woman. The origin of the tumor was identified chest roentgenograms and computed tomography showing a mass in the horizontal fissure and part of the oblique fissure, after an episode of acute pneumonia. The patient had a middle lobectomy and segmentectomy of the right upper lobe. She had local recurrence three months after surgery, receiving after that chemotherapy and radiation therapy. (author)

1996-01-01

82

A case of malignant fibrous histiocytoma probably due to irradiation  

International Nuclear Information System (INIS)

A 61-year-old woman presented with light grayish, broad-based bleeding mass 21 years after radiation therapy for breast cancer. Tumor cells, consisting of many atypical histiocytoid and fibroblastoid cells and a few pleokaryocytes, extended from the upper layer of dermis to the skeletal muscle. She was diagnosed as having malignant fibrous histiocytoma. The concept of this disease is discussed in relation to radiation therapy. (Namekawa, K)

1989-01-01

83

Malignant fibrous histiocytoma of pancreas: presentation of a case  

International Nuclear Information System (INIS)

We present a case of malignant fibrous histiocytoma (MFH) located in the body and tail of the pancreas of a 60-year-old woman. The mass was large, lobulated and well delimited by a pseudocapsule. Pancreatectomy involving the body and tail and splenectomy were performed and the diagnosis was reached on the basis of pathological and immunohistochemical studies. The course was aggressive with local recurrence and liver metastases presenting two months after the operation. The computerized tomography (CT) findings are provided. (Author)

1995-01-01

84

Case of malignant fibrous histiocytoma probably due to irradiation  

Energy Technology Data Exchange (ETDEWEB)

A 61-year-old woman presented with light grayish, broad-based bleeding mass 21 years after radiation therapy for breast cancer. Tumor cells, consisting of many atypical histiocytoid and fibroblastoid cells and a few pleokaryocytes, extended from the upper layer of dermis to the skeletal muscle. She was diagnosed as having malignant fibrous histiocytoma. The concept of this disease is discussed in relation to radiation therapy. (Namekawa, K).

Matsukawa, Ataru; Ishii, Hiroshi; Sakai, Shigenobu.

1989-04-01

85

Myxoid malignant fibrous histiocytoma presenting as a midline nasal mass.  

UK PubMed Central (United Kingdom)

Myxoid malignant fibrous histiocytoma is a rare type of pediatric non-rhabdomyosarcoma soft-tissue sarcoma. The case of a 5-year-old girl is presented, highlighting the potential for multiple pitfalls and aberrant differential diagnoses that need to be identified for successful treatment of pediatric myxofibrosarcomas. An awareness of these tumors and a call for standardized postsurgical treatment protocols is necessary in order to successfully treat children with this disease.

DeRosa J; Smit JR

2012-04-01

86

Postirradiation sarcoma (malignant fibrous histiocytoma) in a patient with squamous cell carcinoma of the uterine cervix  

International Nuclear Information System (INIS)

An autopsy case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation fied 7 years after postoperative external beam radiation therapy (6000 rad) for squamous cell carcinoma of the cervix. To our knowledge, 11 cases of postirradiation malignant fibrous histiocytoma have been reported in the literature and only one occurrence of this neoplasm after treatment for cervical cancer has been described. We review the literature on postirradiation sarcoma with special attention to malignant fibrous histiocytoma. (author)

1983-01-01

87

Postradiation pleomorphic malignant fibrous histiocytoma of the breast  

International Nuclear Information System (INIS)

A case of primary malignant fibrous histiocytoma (MFH) of the breast occurring two years after surgical excision and radiation therapy for a carcinoma of the left breast is reported. Fine needle aspiration was positive for malignant cells, consistent with a pleomorphic sarcoma. Cytologic examination revealed giant cells with marked pleomorphism. Some cells showed single large nuclei with cytoplasmic vacuoles while others revealed multinucleation with foamy cytoplasm, phagocytosed erythrocytes and cellular debris. These findings are considered useful in the cytologic diagnosis of the pleomorphic variant of MFH

1986-01-01

88

Postradiation pleomorphic malignant fibrous histiocytoma of the breast  

Energy Technology Data Exchange (ETDEWEB)

A case of primary malignant fibrous histiocytoma (MFH) of the breast occurring two years after surgical excision and radiation therapy for a carcinoma of the left breast is reported. Fine needle aspiration was positive for malignant cells, consistent with a pleomorphic sarcoma. Cytologic examination revealed giant cells with marked pleomorphism. Some cells showed single large nuclei with cytoplasmic vacuoles while others revealed multinucleation with foamy cytoplasm, phagocytosed erythrocytes and cellular debris. These findings are considered useful in the cytologic diagnosis of the pleomorphic variant of MFH.

Luzzatto, R.; Grossmann, S.; Scholl, J.G.; Recktenvald, M.

1986-01-01

89

Study of malignant fibrous histiocytoma: clinical, statistic and histopatological interrelation.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Malignant fibrous histiocytoma (MFH) is a malignant tumor of soft parts observed at approximately 70% of cases situated at the level of the outsides. PATIENTS AND METHODS: Our study is formed of 14 cases of patients in a period of three years (2007-2010), diagnosed anatomo-pathological with malignant fibrous histiocytoma at the County Hospital of Oradea. The histopathological examination together with the immunohistochemical one is of vital importance in the establishment of the positive diagnostic and furthermore in the establishment of the differential diagnostic with carcinomas, plasmacytomas, osteosarcomas, fibrosarcomas and lymphosarcomas, fact that arouse the doctors to administrate the correct treatment to a specific patient. DISCUSSION: MFH is a tumor of late adulthood that occurs in men more commonly than women. Computer tomography and MRI have been widely used in the diagnosis and staging of MFH. MFH is secondary to another process such as radiation, surgery, fracture, osteonecrosis, Paget's disease, non-ossifying fibroma or fibrous dysplasia 20% of the time. MFH arising from a previous abnormality is usually more aggressive and has a poorer prognosis than primary MFH. Primary osseous MFH is a central lesion found in the diaphysis or metaphysis of the bone that causes aggressive bone destruction and a soft tissue mass. The most common sites in order are the distal femur, proximal tibia, proximal femur and proximal humerus. Primary osseous MFH is less common. MFH is found in the extremities 70-75% of the time and 50% of all cases are in the lower extremity. Other less common sites include the retroperitoneum, and the head and neck. In our study, of 14 patients with malignant fibrous histiocytoma, the highest incidence is during the sixth decade of life and there is a male to female ratio of 8 to 6. In the specialty literature, malignant fibrous histiocytoma tend to occur in children and teenagers but can also occur in older adults as secondary lesions in bone infarcts and radiation fields. This tumor is clinically similar to osteosarcoma and fibrosarcoma, although malignant fibrous histiocytomas have been classified as different from the osteosarcoma group because of a different histology (no tumor bone production). Treatment is similar to that of osteosarcoma. CONCLUSIONS: During our study, the average age was of 61 years in comparison with the specialty literature where the average age was of 50 years. The same as in the specialty literature the cases of fibrous malignant histiocytoma studied are more frequently present at men. Regarding the situation, our study shows the affectation of the long bones especially the femur followed by the radius. The histopathological examination together with the immunohistochemical one is of vital importance in the establishment of the positive diagnostic and furthermore in the establishment of the differential diagnostic with carcinomas, plasmacytomas and lymphosarcomas.

Pobirci DD; Bogdan F; Pobirci O; Petcu CA; Ro?ca E

2011-01-01

90

Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background A malignant fibrous histiocytoma is a soft tissue tumor that most commonly occurs in the extremities, but rarely involves the liver. The clinical characteristics and therapeutic experiences of primary hepatic malignant fibrous histiocytoma are still limited. ...

Yao Dianbo; Dai Chaoliu

91

Malignant fibrous histiocytoma of sternum: an unusual cause of pyrexia of undetermined origin.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Malignant fibrous histiocytoma of the bone is a very rare tumour mainly affecting long bones, and the most common presenting symptom is local pain. A case of malignant fibrous histiocytoma presenting with pyrexia of undetermined origin and arising in the sternum, a localization not previously descri...

Grieco, A.; Caputo, S.; Silvestri, E.; Caradonna, P.; Bertoli, A.; Greco, A. V.

92

An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report  

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Abstract Introduction Malignant fibrous histiocytoma is a very common subtype of soft-tissue sarcoma in middle and late adulthood. However, malignant fibrous histiocytoma of the testis is very rare in adolescents. Case presentation We report here the case of a 14-year-...

Wang Lian-Li; Xie Hui; Fu Hai-Long; Jiang Sen; Wang Xiu-Fang; Jia Mei-Zai; Liu Ze-Hong; Zhao Ya-Ping

93

Malignant fibrous histiocytoma of rectum: Report of a case  

Science.gov (United States)

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma of adults, mostly distributed in the thigh, buttock and groin (46%) and presents rarely in the gastrointestinal tract, classified as gastrointestinal stromal tumors (GIST). MFH is regarded as a diagnosis of exclusion, essentially synonymous with an undifferentiated pleomorphic sarcoma. The recent report presents an 80-year-old man with clinical manifestations of rectal bleeding and final diagnosis of MFH of rectum. It seems that radical resection and adjuvant radiation is important in the management strategy of a patient with such a rare rectal tumor.

Azizi, Rasoul; Mahjoubi, Bahar; Shayanfar, Nasrin; Anaraki, Fakhryalsadat; Zahedi-Shoolami, Leila

2011-01-01

94

Malignant fibrous histiocytoma of the pulmonary artery -a case report-  

International Nuclear Information System (INIS)

We recently experienced a case of primary malignant fibrous histiocytoma of the left pulmonary artery occurred in a 27-year-old man who had 5 months history of intermittent hemoptysis. Chest X-ray revealed multilobulated mass density (about 4x5cm in size) in left hilar area, and another small lobulated nodular density (about 1x1.5cm in size) in left upper lung field, which was intrapulmonary metastatic deposit. CT scan, pulmonary arteriography, and selective left bronchial arteriography after partial resection of the left hilar mass and left upper lobectomy revealed the mass to have the characteristic feature

1987-01-01

95

Malignant fibrous histiocytoma of the pulmonary artery -a case report-  

Energy Technology Data Exchange (ETDEWEB)

We recently experienced a case of primary malignant fibrous histiocytoma of the left pulmonary artery occurred in a 27-year-old man who had 5 months history of intermittent hemoptysis. Chest X-ray revealed multilobulated mass density (about 4x5cm in size) in left hilar area, and another small lobulated nodular density (about 1x1.5cm in size) in left upper lung field, which was intrapulmonary metastatic deposit. CT scan, pulmonary arteriography, and selective left bronchial arteriography after partial resection of the left hilar mass and left upper lobectomy revealed the mass to have the characteristic feature.

Kweon, Young Hwa; Joo, Jeong Hee; Nam, Myung Hyun; Jeon, Seok Chol; Seo, Heung Suk; Lee, Jung Hee; Park, Sung Soo [College of Medicine, Hanyang University, Seoul (Korea, Republic of)

1987-12-15

96

Malignant fibrous histiocytoma of bone (MFH) - a new tumour  

Energy Technology Data Exchange (ETDEWEB)

Malignant fibrous histiocytoma of bone (MFH) is a histologically defined bone tumour, which can be distinguished from osteo- and fibrosarcomas. The present paper deals with the question whether MFH can be distinguished from these tumours on clinical grounds. One hundred and fifty-seven previously published, and four additional cases have been analysed with respect to their localisation and their biological, clinical and radiological behaviour and their prognosis. It was found that MFH can be distinguished from osteosarcomas on clinical grounds and that this is significant in relation to treatment; its distinction from fibro-sarcomas is clinically not justified.

Freyschmidt, J.; Ostertag, H.; Majewski, A.; Korvalian, Z.

1981-07-01

97

Malignant fibrous histiocytoma of bone (MFH) - a new tumour  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma of bone (MFH) is a histologically defined bone tumour, which can be distinguished from osteo- and fibrosarcomas. The present paper deals with the question whether MFH can be distinguished from these tumours on clinical grounds. One hundred and fifty-seven previously published, and four additional cases have been analysed with respect to their localisation and their biological, clinical and radiological behaviour and their prognosis. It was found that MFH can be distinguished from osteosarcomas on clinical grounds and that this is significant in relation to treatment; its distinction from fibro-sarcomas is clinically not justified. (orig.)

1981-01-01

98

Malignant fibrous histiocytoma developing in irradiated sacral chordoma  

Energy Technology Data Exchange (ETDEWEB)

Malignant fibrous histiocytoma (MFH), arising at the site of a sacral chordoma 8 years after massive radiotherapy, is described. Initially, the patient received 7000 rad to the sacral area and, on recurrence, 5 years later, an additional 4000 rad. Two years later, a sacral mass was noted again. Biopsy then revealed MFH; chest x-ray showed multiple lung metastases. A combination chemotherapy, consisting of cyclophosphamide, vincristine, adriamycin (doxorubicin), and DTIC, resulted in a 6 month partial response. Subsequently, the patient died because of progressive metastatic disease. At autopsy, 8 years after diagnosis, both the sacral lesion and the lung metastases proved to be MFH, and no residual chordoma was found.

Halpern, J.; Kopolovic, J.; Catane, R.

1984-06-15

99

Malignant fibrous histiocytoma developing in irradiated sacral chordoma  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma (MFH), arising at the site of a sacral chordoma 8 years after massive radiotherapy, is described. Initially, the patient received 7000 rad to the sacral area and, on recurrence, 5 years later, an additional 4000 rad. Two years later, a sacral mass was noted again. Biopsy then revealed MFH; chest x-ray showed multiple lung metastases. A combination chemotherapy, consisting of cyclophosphamide, vincristine, adriamycin (doxorubicin), and DTIC, resulted in a 6 month partial response. Subsequently, the patient died because of progressive metastatic disease. At autopsy, 8 years after diagnosis, both the sacral lesion and the lung metastases proved to be MFH, and no residual chordoma was found

1984-06-15

100

Malignant fibrous histiocytoma: a case report and literature review.  

Science.gov (United States)

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma in late adult life. It occurs most frequently in the extremities (70%), followed by the retroperitoneum (16%). The occurrence of MFH in the spermatic cord is extremely rare (approximately 50 cases in the literature). We are reporting one case of MFH of the spermatic cord that presented as a hard painful inguinal mass. The patient was treated by a right radical orchiectomy followed by postoperative radiotherapy. The patient remained alive, with no local recurrence after 30 months of follow-up. PMID:20187510

Abou-Jaoude, Maroun; El Ali, Mohamed

 
 
 
 
101

Malignant fibrous histiocytoma of the face: report of a case  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Soft tissue sarcomas in the head and neck region are rare and often present a difficult differential diagnosis. The aim of our presentation is to point out the complexity of the diagnosis, treatment and follow up. Case presentation An eighty-seven year old female patient was referred to our unit with a fast growing brownish lump on the face. Four months beforehand, a benign fibrous histiocytoma (BFH) had been removed from the same location by excision biopsy with wide tumour-free resection margins. Excision biopsy of the recurrent lesion revealed a malignant fibrous histiocytoma (MFH). Radical tumour resection was completed by extended parotidectomy and neck dissection; the skin defect was covered by a regional bi-lobed flap. No adjuvant radio- or chemotherapy was administered. Full functional and cosmetic recovery was achieved; follow-up has been uneventful more than two years postoperatively. Discussion Malignant transformation of BFH is extremely rare and if so, extended radical surgery may give a fair chance for a favourable outcome even in patients with advanced age.

Seper László; Schwab Richárd; Kiattavorncharoen Sirichai; Büchter Andre; Bánkfalvi Ágnes; Joos Ulrich; Piffkó József; Kruse-Loesler Birgit

2007-01-01

102

Adult paratesticular malignant fibrous histiocytoma treated with surgery, systemic chemotherapy and postoperative adjuvant radiotherapy  

Directory of Open Access Journals (Sweden)

Full Text Available Paratesticular malignant fibrous histiocytoma is an extremely rare malignancy of the scrotum. This malignancy has rarely been described in the literature and scant information exists on the optimal management of this cancer. We present here a case of a 57-year-old man with a diagnosis of high-grade malignant fibrous histiocytoma of the left intrascrotal region who underwent radical orchiectomy, systemic chemotherapy and postoperative radiotherapy.

Schmitz Matthew

2006-01-01

103

Sputum cytology of a metastatic postradiation sarcoma. Malignant fibrous histiocytoma  

Energy Technology Data Exchange (ETDEWEB)

A female patient who died of apparent postradiation sarcoma in the inguinal region after irradiating a metastatic squamous cell carcinoma of the same site was reported. For approximately 20 months, the patient had received a total of 6,600 and 9,600 Roentgen to the right para-aortic and inguinal areas, respectively. About 10 years later, she developed a sarcoma, namely a malignant fibrous histiocytoma. Sputum cytology demonstrated numerous giant cells with bizarre nuclei; subsequent chest films also presented apparent metastatic tumor shadows. The cellular characteristics and also rather low incidence of detection of nonepithelial malignant tumor by sputum cytology were briefly discussed, and ways of enhancing cytodiagnostic accuracy were proposed.

Tanaka, T.; Murakami, I.; Awai, S.; Ogura, Y.; Morishita, Y. (Okayama Univ. (Japan). School of Medicine)

1981-04-01

104

Malignant fibrous histiocytoma of the lower lip: A case report  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant fibrous histiocytoma (MFH) represents the diagnosis that is still commonly used by both patients and physicians although in 2002., the World Health Organization (WHO) declassified MFH as a formal diagnostic entity, renaming it as an undifferentiated pleomorphic sarcoma not specifying it further. MFH is extremely rare in the oral cavity. The aim of this article was to describe a newly diagnosed case of primary MFH in a 78-year-old male presented after 4-months history of rapidly increasing swelling of lower lip. Histopathology of the lesion showed highly malignant cell infiltration with epithelioid/spindle cell type morphology. Immunohistochemical study was positive for vimentin (++), S-100 protein (++) and negative for desmin and cytokeratin. The authors discussed the possibilities of immunohistochemical study and necessity of individual treatment plan in patients with MFH, comparing their point of view with other studies.

Pechalova Petia F; Poriazova Elena G; Pavlov Nikolai V; Anavi Benjamin L.

2012-01-01

105

Sputum cytology of a metastatic postradiation sarcoma (malignant fibrous histiocytoma).  

Directory of Open Access Journals (Sweden)

Full Text Available A female patient who died of apparent postradiation sarcoma in the inguinal region after irradiating a metastatic squamous cell carcinoma of the same site was reported. For approximately 20 months, the patient had received a total of 6,600 and 9,600 Roentgen to the right para-aortic and inguinal areas, respectively. About 10 years later, she developed a sarcoma, namely a malignant fibrous histiocytoma. Sputum cytology demonstrated numerous giant cells with bizarre nuclei; subsequent chest films also presented apparent metastatic tumor shadows. The cellular characteristics and also rather low incidence of detection of nonepithelial malignant tumor by sputum cytology were briefly discussed, and ways of enhancing cytodiagnostic accuracy were proposed.

Tanaka,Toshio; Murakami,Itsuko; Awai,Seiji; Ogura,Yasuko; Morishita,Yumiko

1981-01-01

106

Radiosensitivity of an isolated human malignant fibrous histiocytoma cell line  

Energy Technology Data Exchange (ETDEWEB)

A human cell line (YU-137) isolated from a bone of malignant fibrous histiocytoma in bone was evaluated using immunofluorescent staining methods. Cell cycle fractions were studied by flow cytometry. The magnitude of G/sub 2/+M fraction in a cell cycle of an exponentially growing population of YU-137 was higher than that observed in HeLa S3 cells. The doubling time of YU-137 cells was 3.2 days. The radiosensitivity of this cell line was compared with HeLa S3 and HMV-1 cells from dose response curves against X-irradiation. The parameters of radiosensitivity of YU-137 against X-irradiation were n=2.0, D/sub 0/=1.05 Gy and D/sub 0/=0.73 Gy. From these data, the radiosensitivity of YU-137 was discussed. (author).

Kawasaki, Shoji; Mizuta, Akifumi; Kashitani, Naoko; Kuroda, Masahiro; Hiraki, Yoshio; Aono, Kaname; Sato, Jiro; Ogino, Tetsuro; Nakanishi, Takashi.

1989-02-01

107

A postirradiation, myxoid type, malignant fibrous histiocytoma; A case report  

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The authors discuss the case of a 59-year-old man who presented a mass in the dorsum of his right foot. He previously had had a hemangioma in this region from birth, and at the age of 10, radiation therapy had been administered to this region because of an ulcer that had developed. Additionally, so as to cover the ulcer, he had been given a free skin graft and a cross-leg flap. Some 50 years after this radiation, he noticed a mass in his foot, and a microscopic examination of a biopsied specimen of this mass revealed it to be a myxoid type, malignant fibrous histiocytoma (MFH). Thus, a below-the-knee amputation was performed. To the best of their knowledge, the authors report that 29 cases of an MFH developing after radiotherapy have been reported in the Japanese literature, and an analysis of these 29 cases is provided and the details of this case are given. (author).

Takeuchi, Masaki; Higuchi, Ryouhei; Ohsige, Kenji; Kouya, Michiko (Tokyo Metropolitan Fuchu Hospital, Tokyo (Japan)); Nozaki, Motohiro

1993-09-01

108

The CT findings of hepatic and pancreatic malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Objective: To study CT manifestations of hepatic and pancreatic malignant fibrous histiocytoma (MFH). Methods: The CT manifestations were analyzed in two cases of hepatic MFH and one case of pancreatic MFH proved by operation and pathology and the literatures were reviewed. Results: The CT manifestation of MFH was a huge solid or cystic tumor in liver or pancreas. There are separators in solid tumor and wall nodes in the cystic tumor. In scan, the tumor showed peripheral and irregular enhancement. The enhancement pattern was manifested fast-in and slow-out. Conclusion: There was no characteristic CT manifestation in hepatic and pancreatic MFH and the diagnosis was difficult to determine its nature before operation. (authors)

2004-01-01

109

Malignant fibrous histiocytoma: mesenchymal tumor of ubiquitous orgin  

Energy Technology Data Exchange (ETDEWEB)

The malignant form of fibrous histiocytoma (MFH) has attracted significant interest for several reasons: its relative frequency, especially in soft tissues, where it is the most common sarcoma in the adult; its ubiquity, since due to its mesenchymal origin it can be present in numerous locations; and its generally dim prognosis. Despite the interest and controversy that MFH has generated in the oncologic and pathologic disciplines, its radiologic characteristics have not been specifically described. Thirty-nine cases of MFH seen from 1975 to 1983 are presented. Clinical data were obtained in all of the cases and radiologic information was available in 29 cases including conventional radiography in 27, nuclear medicine in 10, sonography in two, computed tomography (CT) in nine, and angiography in four.

Ros, P.R.; Viamonte, M. Jr.; Rywlin, A.M.

1984-04-01

110

Histiocitoma maligno fibroso retroperitoneal/ Retroperitoneal malignant fibrous histiocytoma  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Presentamos un nuevo caso de neoplasia retroperitoneal: un histiocitoma fibroso maligno, en su variedad mixoide, la menos agresiva de ellas. Este es un tumor individualizado de forma relativamente reciente del conjunto de sarcomas retroperitoneales, de escasa frecuencia, clínica inespecífica y mal pronóstico por su alta tendencia a la recidiva y a la producción de metástasis. Abstract in english We report a new case of retroperitoneal tumor: a malignant fibrous histiocytoma, in its less agressive histologyc type, the mixoyd variety. This is a recently isolated histologyc presentation from other sarcomas, with a low incidence, non-specific clinic findings and poor prognosis due to its tendency to reappear and to produce metastasis.

Argüelles Salido, E.; Congregado Ruiz, C.B.; Medina López, R.A.; Pascual del Pobil Moreno, J.L.

2004-09-01

111

A case of cutaneous malignant fibrous histiocytoma with multiple organ metastases.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma is a soft tissue sarcoma that most commonly occurs in the extremities and rarely metastasizes cutaneously. A 79-year-old male patient consulted a dermatologist 11 months after recognizing an intractable ulcer on the right mandible. Punch biopsy revealed eosinophilic tumor cells in the dermal area and proliferation of rich spindle cells. Malignant fibrous histiocytoma or atypical fibroxanthoma was suspected and he was referred to our hospital. Red plaque tumors on the right mandible and right temple were 30 mm and 15 mm in size, respectively. The right mandible lesion was ulcerated. Immunohistochemically, the lesions were positive for CD10, CD74 and alpha-smooth muscle actin. Radiological analysis revealed multiple organ metastases, including bone, liver, lung and skin on the right temple. The patient was diagnosed with malignant fibrous histiocytoma, stage IV and died 8 weeks after the first visit due to respiratory failure. Cutaneous malignant fibrous histiocytoma has a poor prognosis resulting in death.

Suzuki S; Watanabe S; Kato H; Inagaki H; Hattori H; Morita A

2013-02-01

112

Primary malignant fibrous histiocytoma of the abdominal cavity: CT findings and pathological correlation  

Digital Repository Infrastructure Vision for European Research (DRIVER)

AIM: To study computed tomography (CT) features of abdominal malignant fibrous histiocytoma (MFH) in various rare locations. METHODS: We retroprospectively identified cases of MFH involving the abdominal cavity. Particular attention was paid to details regarding imaging features and histological typ...

Bivek Karki; Yi-Kai Xu; Yuan-Kui Wu; Wei-Wei Zhang

113

Case report 505: Malignant fibrous histiocytoma of thigh and liposarcoma in same lower extremity (synchronous lesions)  

International Nuclear Information System (INIS)

CT plays a valuable role in the preoperative evaluation of sarcoma of soft tissues. The present report reveals the radiological and pathological features of malignant fibrous histiocytoma and liposarcoma - lesions which appear in the same patient. (orig./GDG)

1988-01-01

114

A case of cutaneous malignant fibrous histiocytoma with multiple organ metastases.  

Science.gov (United States)

Malignant fibrous histiocytoma is a soft tissue sarcoma that most commonly occurs in the extremities and rarely metastasizes cutaneously. A 79-year-old male patient consulted a dermatologist 11 months after recognizing an intractable ulcer on the right mandible. Punch biopsy revealed eosinophilic tumor cells in the dermal area and proliferation of rich spindle cells. Malignant fibrous histiocytoma or atypical fibroxanthoma was suspected and he was referred to our hospital. Red plaque tumors on the right mandible and right temple were 30 mm and 15 mm in size, respectively. The right mandible lesion was ulcerated. Immunohistochemically, the lesions were positive for CD10, CD74 and alpha-smooth muscle actin. Radiological analysis revealed multiple organ metastases, including bone, liver, lung and skin on the right temple. The patient was diagnosed with malignant fibrous histiocytoma, stage IV and died 8 weeks after the first visit due to respiratory failure. Cutaneous malignant fibrous histiocytoma has a poor prognosis resulting in death. PMID:23347814

Suzuki, Shuji; Watanabe, Shoichi; Kato, Hiroshi; Inagaki, Hiroshi; Hattori, Hideo; Morita, Akimichi

2012-10-13

115

Case report 505: Malignant fibrous histiocytoma of thigh and liposarcoma in same lower extremity (synchronous lesions)  

Energy Technology Data Exchange (ETDEWEB)

CT plays a valuable role in the preoperative evaluation of sarcoma of soft tissues. The present report reveals the radiological and pathological features of malignant fibrous histiocytoma and liposarcoma - lesions which appear in the same patient. (orig./GDG).

Kuhlman, J.E.; Fishman, E.K.; Hruban, R.H.; Almarez, R.

1988-10-01

116

MALIGNANT FIBROUS HISTIOCYTOMA OF THE PENIS A CASE REPORT AND REVIEW OF THE LITERATURE  

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Full Text Available Penile malignant fibrous histiocytoma is an extremely rare tumor. To the best of our knowledge, we present here the fifth primary malignant fibrous histiocytoma of the penis. The patient presented with lung metastasis which initially responded well to systemic chemotherapy with Adriamycin and Ifosfamide, but recurred soon after. The local lesion did not respond to chemotherapy and the patient had to undergo a palliative penectomy. The disease progressed rapidly and the patient died one year after the diagnosis.

Tufan Tarcan; Cenk Murat Yaz?c?; Sevgi Küllü; Ferruh ?im?ek

2009-01-01

117

Histiocitoma fibroso maligno/ Malignant fibrous histiocytoma/ Histiocytome fibreux malin  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Introducción: los sarcomas son tumores malignos de partes blandas que representan 0,7 % de los tumores malignos en general, con una tasa de 3 por cada 100 000. El histiocitoma fibroso maligno resulta un tumor de alto grado incluido en el grupo de los sarcomas de partes blandas. Objetivo: exponer las características citohistológicas, el tratamiento y la evolución de este tumor en un caso estudiado y tratado en el Hospital General Provincial Docente "Roberto Rodríguez (more) Fernández" de Ciego de Ávila. Descripción: se presentó el caso de un varón de 60 años con una gran masa de partes blandas en el muslo izquierdo, de crecimiento progresivo. La masa se trató quirúrgicamente con exéresis en bloque, previos estudios analíticos, arteriografía femoral y ecografía. Conclusiones: el diagnóstico anatomopatológico fue de histiocitoma fibroso maligno variedad pleomórfica; fue remitido al servicio de oncología donde lo trataron con radioterapia. A los 6 meses se encontraba libre de la enfermedad. Se realizó una revisión de la literatura y se analizó su presentación clínica, también los hallazgos histológicos, las pruebas diagnósticas de imagen y el procedimiento terapéutico. Abstract in english Introduction: the sarcomas are soft tissue malignant tumors accounting for the 0.7 % of malignant tumors in general with a rate of 3 by 100 000. The malignant fibrous histiocytoma is a high grade tumor included in the group of soft tissue tumors. Objective: to expose the cytohistologic features, treatment and course of this tumor in study case and treated in "Roberto Rodríguez Fernández" Teaching Provincial Hospital of Ciego de Avila municipality. Description: this is t (more) he case of a male patient aged 60 presenting with an increasing large soft tissue mass in the left thigh. The mass was operated on with block exeresis, analytical previous studies, femoral arteriography and echography. Conclusions: the anatomic and pathologic diagnosis was a malignant fibrous histiocytoma pleomorphous type; the patient was referred to Oncology service where was treated with radiotherapy. At 6 months he was free of disease. A review of literature was performed analyzing its clinical presentation also, its histological findings, the imaging diagnostic test and the therapeutical procedure.

Collazo Álvarez, Hiralio; Torrecilla Silverio, Dewar; Morales Florat, Jorge Luis; Collazo Marín, Stephens Yecc

2012-06-01

118

Aneurysmal benign fibrous histiocytoma of the skin  

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Aneurysmal benign fibrous histiocytoma is a rare variant of benign fibrous histiocytoma. Clinically it has varied appearances and mimic benign and malignant vascular tumors and malignant melanoma resulting in diagnostic difficulties. Histopathological examination is mandatory for diagnosis.

Bal Amanjit; Punia RPS; Mohan Harsh

119

Aneurysmal benign fibrous histiocytoma of the skin  

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Full Text Available Aneurysmal benign fibrous histiocytoma is a rare variant of benign fibrous histiocytoma. Clinically it has varied appearances and mimic benign and malignant vascular tumors and malignant melanoma resulting in diagnostic difficulties. Histopathological examination is mandatory for diagnosis.

Bal Amanjit; Punia RPS; Mohan Harsh

2006-01-01

120

A case of postirradiation malignant fibrous histiocytoma of the temporal region  

International Nuclear Information System (INIS)

A patient developed sarcoma in the left temporal area 11 years after receiving radiation therapy for retinoblastoma. This sarcoma showed light- and electron-microscopic features of malignant fibrous histiocytoma. The patient was treated with postoperative external radiation therapy and chemotherapy. In addition, the literature is reviewed and discussed regarding postirradiation malignant fibrous histocytoma. (author)

1987-01-01

 
 
 
 
121

Postirradiation sarcoma (malignant fibrous histiocytoma) in a patient with squamous cell carcinoma of the uterine cervix. An autopsy case  

Energy Technology Data Exchange (ETDEWEB)

An autopsy case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 7 years after postoperative external beam radiation therapy (6000 rad) for squamous cell carcinoma of the cervix. To our knowledge, 11 cases of postirradiation malignant fibrous histiocytoma have been reported in the literature and only one occurrence of this neoplasm after treatment for cervical cancer has been described. We review the literature on postirradiation sarcoma with special attention to malignant fibrous histiocytoma.

Nagata, Akira; Miyamoto, Yuichi; Etoh, Yasuyuki; Noda, Kazuyoshi; Yamaguchi, Rhusuke (Saga Prefectural Hospital, Saga (Japan))

1983-08-01

122

MR imaging findings of malignant fibrous histiocytoma of bone  

International Nuclear Information System (INIS)

The purpose of this study is to assess magnetic resonance (MR) imaging findings of malignant fibrous histiocytoma (MFH) of bone and to evaluate the role of contrast-enhanced MR imaging in the diagnosis of bone MFH. MR imagings of pathologically proven bone MFH in ten patients were reviewed. Enhanced study was also performed with Gd-DTPA. The MR images were evaluated for signal intensity, homogeneity, marginal definition, presence of internal septation, cortical destruction, soft tissue extension, joint involvement and contrast enhancement. Tumors showed iso- or slightly high signal intensity to muscle on T1-weighted images and heterogeneously high signal intensity on T2-weighted images. Four cases showed poor-marginated border on T2-weighted images and four cases had internal septa. Eight of nine patients with intravenous administration of Gd-DTPA showed contrast enhancement, five were heterogeneous and three were homogeneous. All cases showed cortical destruction and soft tissue extension. Five cases showed joint involvement. Bone MFH showed similar MR imaging findings of soft tissue MFH or other malignant bone tumors, but joint involvement was suggestive finding of bone MFH

1996-01-01

123

MR imaging findings of malignant fibrous histiocytoma of bone  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study is to assess magnetic resonance (MR) imaging findings of malignant fibrous histiocytoma (MFH) of bone and to evaluate the role of contrast-enhanced MR imaging in the diagnosis of bone MFH. MR imagings of pathologically proven bone MFH in ten patients were reviewed. Enhanced study was also performed with Gd-DTPA. The MR images were evaluated for signal intensity, homogeneity, marginal definition, presence of internal septation, cortical destruction, soft tissue extension, joint involvement and contrast enhancement. Tumors showed iso- or slightly high signal intensity to muscle on T1-weighted images and heterogeneously high signal intensity on T2-weighted images. Four cases showed poor-marginated border on T2-weighted images and four cases had internal septa. Eight of nine patients with intravenous administration of Gd-DTPA showed contrast enhancement, five were heterogeneous and three were homogeneous. All cases showed cortical destruction and soft tissue extension. Five cases showed joint involvement. Bone MFH showed similar MR imaging findings of soft tissue MFH or other malignant bone tumors, but joint involvement was suggestive finding of bone MFH.

Lee, Jeong Hoon; Kim, Ki Soo; Lee, Byung Hee; Do, Young Soo; Kim, Kie wan; Chin, Soo Yil [Korea Cancer Center Hospital, Seoul (Korea, Republic of)

1996-01-01

124

Some epidemiological characteristics of malignant fibrous histiocytoma in the Province of Vojvodina  

Directory of Open Access Journals (Sweden)

Full Text Available BACKGROUND: Malignant fibrous histiocytoma is most common soft tissue sarcoma occurring in late adult life, most in the extremities and in the retroperitoneum, usually developing in deep fascia or skeletal muscle. Because of the aggressive nature of the tumor early and complete surgical removal is indicated. The overall survival rate of patients with malignant fibrous histiocytoma ranges from 36% to 58% at 5 years. Malignant fibrous histiocytoma in Vojvodina is still rare malignancy either in incidence or in mortality in both sexes. The population of Vojvodina is about 2 100 000. METHODS: We used a descriptive epidemiological method to analyze incidence and mortality from malignant fibrous histiocytoma in Vojvodina. This study is based on the Cancer Registry data for the ten-year period from 1993 to 2002. RESULTS: During the observed period 37 cases of malignant fibrous histiocytoma were reported (19 men and 18 women). The average age of patients was 50 years. The body site distribution differed between sexes and malignant fibrous histiocytoma was more common on the trunk (retroperitoneum) in men and on the lower limbs in women. The average annual incidence rate for the observed period was 1.82 per 1 000 000 for both sexes. The incidence rate changed irregularly over the observed period with the peak of 9 cases (4.55 per 1 000 000) in 2001. The overall linear trends of incidence and of mortality showed a slight increasing tendency in both sexes, but not significantly. Concerning mortality, the similar patterns were noticed. The mortality rate was 0.83 per 1 000 000. CONCLUSION: According to epidemiological data we obtained it can be concluded that Province of Vojvodina is not a region with an important risk for malignant fibrous histiocytoma; however, the increase of incidence appearing in both men and women should be taken into account very seriously in future.

Nikolin Borislava L.; Dugandžija Tihomir; Salma Svetlana; Trifunovi? Jasna; Vojnovi? Dragana

2005-01-01

125

Malignant fibrous histiocytoma originating from the mesorectum: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Malignant fibrous histiocytoma (MFH) is a common sarcoma affecting soft tissues of the body, especially of the extremities or trunk. Prognosis of the abdominal MFH is usually poor. Case presentation A 52-year-old female presented to our surgical outpatient clinic with a lower abdominal tumor that had been gradually increasing in size. Clinical examination revealed a firm, irregularly surfaced, fixed, painless, child-head-sized tumor located in her lower abdomen. Computed tomography (CT) and magnetic resonance imaging (MRI) of the abdomen revealed a polycystic tumor at the lower abdomen which was 15 × 13 × 11 cm in diameter and encased the colorectum to the left back side. A barium enema and a colonoscopy showed direct invasion to the rectum. In 2001, the tumor had been excised along with a low anterior resection of the rectum because of direct invasion. The origin of this tumor was the mesorectum. The weight of the excised tumor was 1,500 g, including 800 ml of a brown fluid. A histopathological diagnosis revealed a common type of MFH, in which mitotic figures are frequently seen. Conclusion This patient has survived without recurrence, for approximately 8 years since the completed tumor resection. It is important to obtain a complete resection during the MFH treatment.

Nakayama Yoshifumi; Minagawa Noritaka; Torigoe Takayuki; Yamaguchi Koji

2011-01-01

126

Postirradiation sarcoma (malignant fibrous histiocytoma) following uterine cervical cancer  

International Nuclear Information System (INIS)

A case of postirradiation sarcoma, a malignant fibrous histiocytoma, is described. The tumor occurred in the radiation field (the buttock) 8 years after radiation therapy for keratinizing squamous cell carcinoma of the uterine cervix. The 68-year-old female patient with the inital diagnosis of cervical cancer was treated with pelvic irradiation in 1973. She did well after that with no evidence of disease until 1981 when she developed an enlarging mass in the right buttock within the field of the previous radiation therapy. Microscopically, the tumor at biopsy was composed of pleomorphic histiocyte-like cells, spindle-sphaped cells arranged in a storiform pattern and multinucleated giant cells with bizarre nuclei. Cytodiagnostically, two types of cells, fibroblast-like cells ane histiocyte-like cells, were found. And some cells were considered to be transitional forms, intermediate between fibroblast and histiocytes. Multinucleated pleomorphic giant cells were sometimes seen. Ultrastructurally, the same types of cells were confirmed. These cells contained large numbers of rough endoplasmic reticula with dilated lumens, vacuoles, lysosomal structures, and lipid droplets. (author)

1984-01-01

127

Postirradiation sarcoma (malignant fibrous histiocytoma) following uterine cervical cancer  

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A case of postirradiation sarcoma, a malignant fibrous histiocytoma, is described. The tumor occurred in the radiation field (the buttock) 8 years after radiation therapy for keratinizing squamous cell carcinoma of the uterine cervix. The 68-year-old female patient with the inital diagnosis of cervical cancer was treated with pelvic irradiation in 1973. She did well after that with no evidence of disease until 1981 when she developed an enlarging mass in the right buttock within the field of the previous radiation therapy. Microscopically, the tumor at biopsy was composed of pleomorphic histiocyte-like cells, spindle-sphaped cells arranged in a storiform pattern and multinucleated giant cells with bizarre nuclei. Cytodiagnostically, two types of cells, fibroblast-like cells ane histiocyte-like cells, were found. And some cells were considered to be transitional forms, intermediate between fibroblast and histiocytes. Multinucleated pleomorphic giant cells were sometimes seen. Ultrastructurally, the same types of cells were confirmed. These cells contained large numbers of rough endoplasmic reticula with dilated lumens, vacuoles, lysosomal structures, and lipid droplets. (author).

Noda, Tsuneo; Tomii, Yoshifumi; Saitoh, Shigeru; Ichijo, Motohiko; Ito, Hiroko; Adachi, Hironari; Kawai, Kazuo

1984-10-01

128

Malignant fibrous histiocytoma of the bucca: a case report.  

Science.gov (United States)

Malignant fibrous histiocytoma (MFH) is the most common soft-tissue sarcoma, but is relatively uncommon in head and neck area. Histologically, it is difficult to distinguish this tumor from other sarcomas and carcinomas. Surgery is the most reliable treatment for MFH, but the 5-year survival rate for cases of this tumor in the head and neck is low in comparison with MFH of the extremities and trunk. In the case reported here, the patient was a 61-year-old man who presented with swelling and pain of the left bucca. A CT scan demonstrated a 2.5 cm x 5.0 cm inhomogeneous lesion. In MRI, the tumor displayed an inhomogeneous isointense signal on T1-weighted images and a high-intensity signal on T2-weighted images. Fine-needle aspiration (FNA) was performed twice but we were unable to reach a definitive diagnosis histologically. MFH was subsequently diagnosed by open biopsy, and external radiotherapy with 38 Gy of radiation was performed. However, the tumor enlarged after this therapy, and therefore CyberKnife therapy was performed twice, after which the tumor gradually reduced in size. The patient is alive after a follow-up period of 22 months, and therefore we suggest that CyberKnife treatment may be useful for head and neck MFH. PMID:17888601

Nagano, Hiromi; Deguchi, Kouji; Kurono, Yuichi

2007-09-20

129

Transformation of Hodgkin's disease into malignant fibrous histiocytoma.  

UK PubMed Central (United Kingdom)

The continuity that exists between Hodgkin's disease and the fibrohistiocytoses has only recently been recognized. Four cases are presented that illustrate this phenomenon. The fibrohistiocytic component of the Hodgkin's lesion may lag behind the lymphoreticular component, may be present in equal proportion, or may assume a dominant role, with the emergence of a frank fibrohistiocytosis or fibrous histiocytoma being evidenced as the lymphoreticular component recedes.

Suster S

1986-01-01

130

Adult paratesticular malignant fibrous histiocytoma treated with surgery, systemic chemotherapy and postoperative adjuvant radiotherapy  

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Paratesticular malignant fibrous histiocytoma is an extremely rare malignancy of the scrotum. This malignancy has rarely been described in the literature and scant information exists on the optimal management of this cancer. We present here a case of a 57-year-old man with a diagnosis of high-grade ...

Schmitz Matthew

131

An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Malignant fibrous histiocytoma is a very common subtype of soft-tissue sarcoma in middle and late adulthood. However, malignant fibrous histiocytoma of the testis is very rare in adolescents. CASE PRESENTATION: We report here the case of a 14-year-old Han Chinese boy, who presented with left scrotal mass lasting for 20 days along with distending pain for 5 days. A physical examination revealed a chicken egg-sized, firm, well-defined mass and unclear epididymis. A B-scan ultrasonography of the left scrotum displayed a 9.0×5.2×4.5cm medium- or low-echoic lobulated mass, which suggested a left testicular neoplasm. A fine needle aspiration cytology examination revealed that the cells obtained from the patient's testicular neoplasm were composed of myxoid spindle, and ovoid cells with nuclear atypia and mitotic activity, and arranged in a whirlpool or storiform pattern. Under histological examination, the tumor cells were arranged in a storiform pattern, which displayed mucoid matrix degeneration, and grew invasively. Consequently, a histopathological diagnosis suggested myxofibrosarcoma (or myxoid malignant fibrous histiocytoma). CONCLUSIONS: An ultrasonic examination combined with fine needle aspiration cytology should be helpful for the initial differential diagnosis of testicular malignant fibrous histiocytoma. However, the final confirmation relies on histopathological examination. To the best of our knowledge, this is the first reported case of malignant fibrous histiocytoma of the testis in an adolescent.

Wang LL; Xie H; Fu HL; Jiang S; Wang XF; Jia MZ; Liu ZH; Zhao YP

2013-01-01

132

An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Introduction Malignant fibrous histiocytoma is a very common subtype of soft-tissue sarcoma in middle and late adulthood. However, malignant fibrous histiocytoma of the testis is very rare in adolescents. Case presentation We report here the case of a 14-year-old Han Chinese boy, who presented with left scrotal mass lasting for 20 days along with distending pain for 5 days. A physical examination revealed a chicken egg-sized, firm, well-defined mass and unclear epididymis. A B-scan ultrasonography of the left scrotum displayed a 9.0×5.2×4.5cm medium- or low-echoic lobulated mass, which suggested a left testicular neoplasm. A fine needle aspiration cytology examination revealed that the cells obtained from the patient’s testicular neoplasm were composed of myxoid spindle, and ovoid cells with nuclear atypia and mitotic activity, and arranged in a whirlpool or storiform pattern. Under histological examination, the tumor cells were arranged in a storiform pattern, which displayed mucoid matrix degeneration, and grew invasively. Consequently, a histopathological diagnosis suggested myxofibrosarcoma (or myxoid malignant fibrous histiocytoma). Conclusions An ultrasonic examination combined with fine needle aspiration cytology should be helpful for the initial differential diagnosis of testicular malignant fibrous histiocytoma. However, the final confirmation relies on histopathological examination. To the best of our knowledge, this is the first reported case of malignant fibrous histiocytoma of the testis in an adolescent.

Wang Lian-Li; Xie Hui; Fu Hai-Long; Jiang Sen; Wang Xiu-Fang; Jia Mei-Zai; Liu Ze-Hong; Zhao Ya-Ping

2013-01-01

133

Postirradiation malignant fibrous histiocytoma expressing cytokeratin. Implications for the immunodiagnosis of sarcomas  

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A malignant fibrous histiocytoma of the sacrum complicating the course of radiation therapy for endometrial carcinoma is presented. Although the tumor fulfilled the clinical, radiologic, and histologic criteria for a postirradiation malignant fibrous histiocytoma of bone, it also expressed cytokeratin. That this immunoreactivity reflected keratin synthesis by the tumor and not an unusual pattern of cross-reactivity with another intermediate filament such as vimentin is strongly suggested by the reproducibility of the immunoreactivity utilizing both polyclonal and monoclonal antibodies and extinction of the immunoreactivity following absorption of the primary antiserum with keratin proteins. This is the first reported instance of keratin expression by a malignant fibrous histiocytoma; it indicates that sarcomas apart from synovial sarcoma and epithelioid sarcoma may sometimes express this protein.

Weiss, S.W.; Bratthauer, G.L.; Morris, P.A.

1988-07-01

134

Postirradiation malignant fibrous histiocytoma expressing cytokeratin. Implications for the immunodiagnosis of sarcomas  

International Nuclear Information System (INIS)

A malignant fibrous histiocytoma of the sacrum complicating the course of radiation therapy for endometrial carcinoma is presented. Although the tumor fulfilled the clinical, radiologic, and histologic criteria for a postirradiation malignant fibrous histiocytoma of bone, it also expressed cytokeratin. That this immunoreactivity reflected keratin synthesis by the tumor and not an unusual pattern of cross-reactivity with another intermediate filament such as vimentin is strongly suggested by the reproducibility of the immunoreactivity utilizing both polyclonal and monoclonal antibodies and extinction of the immunoreactivity following absorption of the primary antiserum with keratin proteins. This is the first reported instance of keratin expression by a malignant fibrous histiocytoma; it indicates that sarcomas apart from synovial sarcoma and epithelioid sarcoma may sometimes express this protein

1988-01-01

135

Clinical analysis of 10 patients with primary malignant fibrous histiocytoma of the lung  

International Nuclear Information System (INIS)

Objective: Objective To study the treatment method and prognosis of primary malignant fibrous histiocytoma of the lung. Methods: Ten patients with primary malignant fibrous histiocytoma of the lung proved by histopathology were reviewed retrospectively. Five were treated by surgery alone, 3 by postoperative radiotherapy and 2 by postoperative chemotherapy. Results: Six of ten patients were able to survive more than 1 year. Four of the six survived more than 2 years and 3 more than 3 years. The 1-, 2-year survival rates were 60% and 40%, respectively. The relapse sites after treatment included: local recurrence (n=1); distant metastasis (n=1) and local recurrence plus distant metastasis (n=3), the interval ranging from 1 to 18 months. Conclusions: The prognosis of primary malignant fibrous histiocytoma of the lung is poor. Surgery is the main treatment method. The role of either postoperative radiation therapy or chemotherapy remains unclear. (authors)

2004-01-01

136

Post radiation sarcoma (malignant fibrous histiocytoma) of the cervical spine following ependymoma (a case report).  

UK PubMed Central (United Kingdom)

A case is reported of a 36 y/o man treated with radiation therapy for cervical cord ependymoma who developed malignant fibrous histiocytoma of the cervical spine 15 years later. Pathology revealed the sarcoma adjacent to the recurrent ependymoma. Post-radiation sarcomas following treatment of central nervous system malignancies is discussed.

Nadeem SQ; Feun LG; Bruce-Gregorios JH; Green B

1991-12-01

137

Post radiation sarcoma (malignant fibrous histiocytoma) of the cervical spine following ependymoma (a case report).  

Science.gov (United States)

A case is reported of a 36 y/o man treated with radiation therapy for cervical cord ependymoma who developed malignant fibrous histiocytoma of the cervical spine 15 years later. Pathology revealed the sarcoma adjacent to the recurrent ependymoma. Post-radiation sarcomas following treatment of central nervous system malignancies is discussed. PMID:1668408

Nadeem, S Q; Feun, L G; Bruce-Gregorios, J H; Green, B

1991-12-01

138

Recurrent aneurysmal fibrous histiocytoma  

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Aneurysmal fibrous histiocytoma is a rare variant of cutaneous fibrous histiocytoma that results from blood vessel proliferation and haemorrhage into a fibrous histiocytoma. The resulting lesion has a very different clinical appearance, hence the potential confusion with other skin lesions. This rep...

Sheehan, K M; Leader, M B; Sexton, S; Cunningham, F; Leen, E

139

Malignant fibrous histiocytoma developed in the chest wall following irradiation treatment for breast cancer  

International Nuclear Information System (INIS)

An autopsy case of malignant fibrous histiocytoma of the chest wall occurring in a 67-year-old female was reported. She had a history of radical mastectomy and postoperative irradiation for breast cancer. 19 years later, she developed malignant fibrous histiocytoma in the chest wall. The post-mortem examination revealed a tumor in the chest wall invading the anterior mediastinum and metastasizing to the apex of the left lung. The irradiation was implicated in the cause of the tumor in this patient. (author)

1979-01-01

140

Malignant fibrous histiocytoma of soft tissue. Possibilities and limitations of computed tomography  

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Computed tomography was performed in 27 patients with confirmed malignant fibrous histiocytoma of the soft tissue. Compared with the CT results obtained in other tumours of the soft tissues, CT accuracy in malignant fibrous histiocytoma was only 74%. Non-typical attenuation values, diffuse tumour growth and non-typical contrast enhancement are discussed as reasons for the diagnostic understaging or overstaging of these soft tissue tumours. A higher accuracy was found on ultrasound examination with regard to tumour extension. Bone destruction was better visualised by CT. A base-line CT is recommended postoperatively for the earlier detection of recurrent tumours in further investigations.

Rotte, K.H.; Kleinau, H.; Kriedemann, E.; Perlick, E.; Schmidt-Peter, P.

1988-05-01

 
 
 
 
141

A case report of the malignant fibrous histiocytoma of the mandible  

International Nuclear Information System (INIS)

The author observed a case of the malignant fibrous histiocytoma of the mandible in 23 aged male patient, who had come to the Infirmary of Dental College, Yonsei University. With the help of careful analysis of radiographic and clinicopathologic findings, the author had obtained the results as follows. 1. Lesion occurred at 22 years of age. 2. Traumatic history or other special predisposing factor were not seen. 3. Lesion appeared as a intraosseous primary tumor not showing any metastatic change. 4. The author have concluded this disease as a malignant fibrous histiocytoma of the mandible according to serial findings.

1984-01-01

142

A case report of the malignant fibrous histiocytoma of the mandible  

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The author observed a case of the malignant fibrous histiocytoma of the mandible in 23 aged male patient, who had come to the Infirmary of Dental College, Yonsei University. With the help of careful analysis of radiographic and clinicopathologic findings, the author had obtained the results as follows. 1. Lesion occurred at 22 years of age. 2. Traumatic history or other special predisposing factor were not seen. 3. Lesion appeared as a intraosseous primary tumor not showing any metastatic change. 4. The author have concluded this disease as a malignant fibrous histiocytoma of the mandible according to serial findings.

Park, Chang Seo [Department of Radiology, College of Dentistry, Yonsei University, Seoul (Korea, Republic of)

1984-11-15

143

Haematoma-like primary intracranial malignant fibrous histiocytoma in a 5-year-old girl  

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We present CT and MRI of an intracranial malignant fibrous histiocytoma in a 5-year-old girl with headache and vomiting. This case is unusual particular by virtue of its radiological appearances and the young age of the patient. (orig.)

Oezhan, S.; Tali, E.T.; Isik, S.; Saygili, M.R. [Gazi Univ., Dept. of Radiology, Ankara (Turkey); Baykaner, K. [Gazi Univ., Dept. of Neurosurgery, Ankara (Turkey)

1999-07-01

144

Transanal excision of a malignant fibrous histiocytoma of anal canal: A case report and literature review  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant fibrous histiocytoma, which is composed of spindle-shaped cells arranged in a pleomorphic and storiform pattern, is rarely found in the colorectum. Although complete surgical excision remains the main stem of therapy, an optimal treatment strategy according to the stage has not been elucidated. We report a case of a 63-year-old woman with an ulcerative lesion in the anorectal junction and a final diagnosis of malignant fibrous histiocytoma. We introduced an access for transanal local excision and adjuvant radiotherapy because the patient refused abdominoperineal resection. No local recurrences or distant metastases were observed 15 mo after the operation. To our knowledge, this is the first case reported in the English literature of a malignant fibrous histiocytoma treated with the transanal local excision and adjuvant radiotherapy. This report showed that this approach is selectively reserved for early-stage malignant fibrous histiocytoma and for those patients who refuse radical surgery because of the risk in a permanent colostomy.

Beom Gyu Kim, In Taik Chang, Jun Seok Park, Yoo Shin Choi, Gi Hyeon Kim, Eon Sub Park, Chang Hwan Choi

2008-01-01

145

Immunohistochemical, quantitative immunoelectron microscopic, and DNA cytofluorometric characterization of chemically induced rat malignant fibrous histiocytoma.  

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Malignant fibrous histiocytoma (MFH) was induced in rats by injection of 9,10-dimethyl-1,2-benzanthracene. Using cell suspensions prepared from the heterotransplanted nude mouse tumor as immunogen, a monoclonal antibody, (MAb), MEP-1, against fibroblastlike MFH tumor cells was generated. In the prim...

Tsuchiya, T.; Takahashi, K.; Takeya, M.; Hosokawa, Y.; Hattori, T.; Takagi, K.

146

Intracranial cystic malignant fibrous histiocytoma in a child: Sonographic and CT findings  

International Nuclear Information System (INIS)

Primary intracranial cystic malignant fibrous histiocytoma (MFH) is an extremely rare tumor with only 15 cases reported. Only three cases of cystic intracranial MFH are found in the literature. We present the sonographic and CT findings in a child with such a lesion. (orig.)

1990-01-01

147

Simultaneous occurrence of malignant fibrous histiocytoma and hepatocellular carcinoma in cirrhotic liver: A case report  

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Primary hepatic malignant fibrous histiocytoma (MFH) is rarely encountered. There have been no reports to date of hepatic MFH associated with liver cirrhosis. The presence of liver cirrhosis is considered an adjunctive feature favoring sarcomatoid hepatocellular carcinoma (HCC) in the diagnosis of s...

Hee Sang Hwang; Nam Du Ha; Yoong Ki Jeong; Jae Hee Suh; Hye Jeong Choi; Young Min Kim; Hee Jeong Cha

148

Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features  

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Abstract Background The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a series of 57 so-called MFH of bone within the framework of...

Mertens Fredrik; Romeo Salvatore; Bovée Judith VMG; Tirabosco Roberto; Athanasou Nick; Alberghini Marco; Hogendoorn Pancras CW

149

Comparative genomic hybridization of malignant fibrous histiocytoma reveals a novel prognostic marker.  

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DNA sequence copy number changes were studied by comparative genomic hybridization (CGH) along all chromosomes in 58 samples of malignant fibrous histiocytoma (MFH). The material consisted of 43 primary tumors (9 of myxoid and 34 of storiform-pleomorphic subtype), 13 local recurrences (2 myxoid and ...

Larramendy, M. L.; Tarkkanen, M.; Blomqvist, C.; Virolainen, M.; Wiklund, T.; Asko-Seljavaara, S.; Elomaa, I.; Knuutila, S.

150

Thallium 201 and Gallium 67 uptake in malignant fibrous histiocytoma of the heart  

International Nuclear Information System (INIS)

A patient with malignant fibrous histiocytoma of the heart is described who was initially presented with a left atrial tumor. Subsequent 201Tl and 67Ga scintigraphy showed massive uptake of the tracers by the tumor and the pattern of uptake was thought to reflect underlying necrosis and hemorrhage within the tumor

1986-01-01

151

Giant Cell Malignant Fibrous Histiocytoma of the Breast: A Case Report  

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A case of primary malignant fibrous histiocytoma of the breast is reported. The patient was a 48-yr-old woman with a huge tumor involving almost the entire left breast. The central portion of her left breast was already rotted by extensive necrosis and inflammation. She was treated by radical mastec...

Oh, Se Jeong; Kim, Kyoung Mee; Hong, Tae Ho; Park, Woo Chan; Kim, Jeong Soo; Jung, Sang Seol

152

A case of primary malignant fibrous histiocytoma of the pancreas: CT and MRI findings  

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Primary malignant fibrous histiocytoma (MFH) of the pancreas is rare and a distinct clinical entity. We report a case of recurrence of pancreatic MFH with computed tomography (CT) and magnetic resonance imaging (MRI) findings. A 67-year-old man presented with a history of decreased body weight over ...

Yu, Ri-Sheng; Wang, Jia-Wei; Chen, Ying; Ding, Wen-Hong; Xu, Xiu-Fang; Chen, Li-Rong

153

Remission of a malignant fibrous histiocytoma under combined radiochemotherapy: Monitoring via MR  

International Nuclear Information System (INIS)

In the case under report, combined radio- and chemotherapy proved effective against an advanced, malignant fibrous histiocytoma. MRT permitted safe documentation of the course of the disease, making light demands on the patient. Eleven months after terminating treatment, the partial remission of the patient is continuing. (orig.)

1990-01-01

154

Malignant fibrous histiocytoma of the pulmonary vein with prolapse through the mitral valve orifice.  

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We present the case of a 33 year old white woman with malignant fibrous histiocytoma arising from the pulmonary vein and prolapsing through the mitral valve, causing acute heart failure. The patient underwent emergency cardiothoracic surgery with resection of the tumour while on cardiopulmonary bypa...

Khan, M. A.; Davidson, R. C.

155

Origin and relationship between different cell types in malignant fibrous histiocytoma.  

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The derivation of histiocyte-like cells in malignant fibrous histiocytoma (MFH) has been a matter of debate. To shed light on this problem two cell lines from two subsequent recurrencies of MFH were established. The existence of two different cell populations, mainly fibroblast-like in the first cel...

Genberg, M.; Mark, J.; Hakelius, L.; Ericsson, J.; Nistér, M.

156

Thallium 201 and Gallium 67 uptake in malignant fibrous histiocytoma of the heart  

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A patient with malignant fibrous histiocytoma of the heart is described who was initially presented with a left atrial tumor. Subsequent /sup 201/Tl and /sup 67/Ga scintigraphy showed massive uptake of the tracers by the tumor and the pattern of uptake was thought to reflect underlying necrosis and hemorrhage within the tumor.

Minamiji, K.; Yamasaki, T.; Nakao, M.; Furumoto, M.; Yoshida, Y.

1986-02-01

157

Contrast-enhanced sonographic appearance of malignant fibrous histiocytoma in the sigmoid colon: a case report.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma (MFH) of the sigmoid colon is extremely rare and imaging characteristics of MFH during contrast-enhanced sonography have not been described yet. Here we report the case of a 55-year-old man suffering from MFH in the sigmoid colon, with an emphasis on contrast-enhanced sonography findings.

Wang YJ; Tang SS; Zhao Y

2012-09-01

158

Myxoid Type of Malignant Fibrous Histiocytoma of the Maxillary Sinus: A Case Report  

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Introduction: Myxofibrosarcoma was originally described as the myxoid variant of Malignant Fibrous Histiocytoma (MFH), a high-grade and aggressive sarcoma, which is very uncommon in the head and neck region, with about 100 cases reported up to now. MFH occurring in the maxillary sinus is so rare tha...

Amir Hossein Jafarian; Abbas Ali Omidi; Mohammad Mehdi Ghasemi; Bahareh Joushan

159

Haematoma-like primary intracranial malignant fibrous histiocytoma in a 5-year-old girl  

International Nuclear Information System (INIS)

We present CT and MRI of an intracranial malignant fibrous histiocytoma in a 5-year-old girl with headache and vomiting. This case is unusual particular by virtue of its radiological appearances and the young age of the patient. (orig.)

1999-01-01

160

Primary malignant fibrous histiocytoma of the lung in a pediatric patient  

International Nuclear Information System (INIS)

The case of a girl with primary malignant fibrous histiocytoma of the lung is presented. The patient presented no previous pathology. Laboratory tests, chest X-ray, chest ultrasound and computed tomography were performed, but the definitive diagnosis was based on biopsy. (Author) 10 refs

1998-01-01

 
 
 
 
161

Malignant fibrous histiocytoma. Expression of monocyte/macrophage differentiation antigens detected with monoclonal antibodies.  

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Monoclonal antibodies were used in an investigation of the histogenesis of malignant fibrous histiocytoma (MFH), a neoplasm with morphologic features of both fibroblastic and histiocytic differentiation. In 4 cases of MFH studied, the tumor cells were found to react uniformly with antibodies to dete...

Strauchen, J. A.; Dimitriu-Bona, A.

162

Malignant Fibrous Histiocytoma of the Kidney Treated with Nephrectomy and Adjuvant Radiotherapy: A Case Report  

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Malignant fibrous histiocytoma (MFH) usually presents in the extremities or retroperitoneum. Cases involving the kidney are rare and portend a poor prognosis. Although radical nephrectomy is the most beneficial curative choice for this neoplasm, patients are often treated with adjuvant chemotherapy ...

Marchese, Rita; Bufo, Pantaleo; Carrieri, Giuseppe; Bove, Giuseppe

163

Malignant fibrous histiocytoma of soft tissue with metaplastic bone and cartilage formation  

International Nuclear Information System (INIS)

The presence of bone and cartilage in some cases of malignant fibrous histiocytoma of the soft tissue as a microscopic finding has been reported previously but little note has been taken of the radiologic manifestations of these tumor elements. A series of five such cases with sufficient metaplastic osseous and cartilaginous elements to produce roentgenographic evidence of their presence is reported here. An additional two cases showed only histologic evidence of bone or cartilage formation. The reactive ossification tends to be peripheral in location, involving the pseudocapsule of the sarcoma or its fibrous septa. In three there was a zoning pattern with peripheral or polar orientation, strongly suggesting the diagnosis of myositis ossificans. The latter was the diagnosis considered radiologically in four of the five cases. Malignant fibrous histiocytoma with reactive bone and cartilage must be considered in the differential diagnosis of soft tissue masses with calcific densities, particularly when these occur in tumors of the extremities. (orig.)

1982-01-01

164

Malignant fibrous histiocytoma of soft tissue with metaplastic bone and cartilage formation  

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The presence of bone and cartilage in some cases of malignant fibrous histiocytoma of the soft tissue as a microscopic finding has been reported previously but little note has been taken of the radiologic manifestations of these tumor elements. A series of five such cases with sufficient metaplastic osseous and cartilaginous elements to produce roentgenographic evidence of their presence is reported here. An additional two cases showed only histologic evidence of bone or cartilage formation. The reactive ossification tends to be peripheral in location, involving the pseudocapsule of the sarcoma or its fibrous septa. In three there was a zoning pattern with peripheral or polar orientation, strongly suggesting the diagnosis of myositis ossificans. The latter was the diagnosis considered radiologically in four of the five cases. Malignant fibrous histiocytoma with reactive bone and cartilage must be considered in the differential diagnosis of soft tissue masses with calcific densities, particularly when these occur in tumors of the extremities.

Dorfman, H.D.; Bhagavan, B.S.

1982-05-01

165

A case of malignant fibrous histiocytoma arising in the irradiated maxilla  

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A malignant fibrous histiocytoma (MFH) arising in the irradiated maxilla is reported. The patient was a 59-year-old Japanese female who was referred to us for a relatively well defined and lobulated tumor extending from the right buccal mucosa to left hard palate. Her past medical history revealed that she had had a squamous cell carcinoma of the right buccal mucosa treated by 145 Gy of radiotherapy 3 years previously. Although the patient underwent a bilateral partial maxillectomy, she died due to extensive local recurrence 14 months postoperatively. Histopathologically, proliferation of atypical tumor cells of non-epithelial origin, i.e., spindle-shaped fibroblastic cells, histiocytic cells and bizarre multinucleated giant cells, were noted. Furthermore, a storiform pattern was also seen in part of the lesion. These features suggested that this care was a postirradiation malignant fibrous histiocytoma. (author).

Fukuta, Yoshiyasu; Yamada, Kazumi; Ohmura, Hiromi; Kudo, Keigo; Takeda, Yasunori (Iwate Medical Univ., Morioka (Japan). School of Dentistry)

1994-03-01

166

A case of malignant fibrous histiocytoma arising in the irradiated maxilla  

International Nuclear Information System (INIS)

A malignant fibrous histiocytoma (MFH) arising in the irradiated maxilla is reported. The patient was a 59-year-old Japanese female who was referred to us for a relatively well defined and lobulated tumor extending from the right buccal mucosa to left hard palate. Her past medical history revealed that she had had a squamous cell carcinoma of the right buccal mucosa treated by 145 Gy of radiotherapy 3 years previously. Although the patient underwent a bilateral partial maxillectomy, she died due to extensive local recurrence 14 months postoperatively. Histopathologically, proliferation of atypical tumor cells of non-epithelial origin, i.e., spindle-shaped fibroblastic cells, histiocytic cells and bizarre multinucleated giant cells, were noted. Furthermore, a storiform pattern was also seen in part of the lesion. These features suggested that this care was a postirradiation malignant fibrous histiocytoma. (author)

1994-01-01

167

Primary Giant Cell Malignant Fibrous Histiocytoma of the Kidney with Staghorn Calculi  

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Full Text Available Malignant fibrous histiocytomas (MFH) as primary renal tumours are rare, with less than 50 cases described in the literature. We report a case of primary renal MFH of giant cell type in a 56-year-old man, who presented with bilateral dull flank pain, intermittent gross haematuria and body weight loss (6 kg in 3 months). Intravenous urography, computerized tomography (CT) and magnetic resonance image (MRI) showed right ureteral stones with mild hydronephrosis, and a solid mass at the lower pole of the left kidney associated with staghorn calculi, as well as tumour thrombi in the left renal vein and inferior vena cava. Left radical nephrectomy and evacuation of tumour thrombi from the left renal vein and inferior vena cava were performed. Histopathologic examination revealed malignant fibrous histiocytoma (MFH) of giant cell type. To the best of our knowledge, this is the first report of primary renal MFH associated with staghorn calculi.

Chen C; Lee P; Han W; Shen K

2003-01-01

168

Fibrosarcoma and malignant fibrous histiocytoma of long bones: Radiographic features and grading  

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The salient radiological features of 102 cases of fibrosarcoma and of so-called malignant fibrous histiocytoma (MFH) of the long bones are presented. All cases registered with the Netherlands Committee on Bone Tumours in the period 1953-1976, were originally classified as fibrosarcoma. In a recent review of the pathological material approximately half of these tumours were reinterpreted as malignant fibrous histiocytoma. As the two neoplasms demonstrate no difference in their clinical picture, radiological appearance, and survival statistics, we did not study both groups separately. Favourable radiographic signs which suggest a longer survival rate included: a geographic type of bone destruction, eccentric location, and cortical destruction involving no more than two quadrants of the bone circumference. Based on these findings a grading system is presented which differs from that proposed by Lodwick et al.

Taconis, W.K.; Mulder, J.D.

1984-04-01

169

Fibrosarcoma and malignant fibrous histiocytoma of long bones: Radiographic features and grading  

International Nuclear Information System (INIS)

The salient radiological features of 102 cases of fibrosarcoma and of so-called malignant fibrous histiocytoma (MFH) of the long bones are presented. All cases registered with the Netherlands Committee on Bone Tumours in the period 1953-1976, were originally classified as fibrosarcoma. In a recent review of the pathological material approximately half of these tumours were reinterpreted as malignant fibrous histiocytoma. As the two neoplasms demonstrate no difference in their clinical picture, radiological appearance, and survival statistics, we did not study both groups separately. Favourable radiographic signs which suggest a longer survival rate included: a geographic type of bone destruction, eccentric location, and cortical destruction involving no more than two quadrants of the bone circumference. Based on these findings a grading system is presented which differs from that proposed by Lodwick et al. (orig.)

1984-01-01

170

Primary Malignant Fibrous Histiocytoma of the Kidney: Report of a Case  

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Full Text Available Primary renal malignant fibrous histiocytoma is extremely rare. The prognosis is generally poor because of the high rate of local recurrence even if radical surgery is performed. We report a case of primary renal malignant fibrous histiocytoma in a 43-year-old woman.A well-defined renal mass (10x9x7cm) with lobulated contour was revealed by abdominal ultrasonography and computerized tomography in our patient who presented with left-flank pain. The contralateral kidney and renal functions were normal. No other primary tumor focus was detected by screening performed to exclude a metastasis to the kidney. However, a nodule consistent with metastasis was identified in the liver. The patient underwent left radical nephrectomy. A huge, yellowish-white, partly necrotic neoplasm infiltrating the renal parenchyma, perirenal fat and adrenal tissue was revealed by gross examination. Microscopically, the tumor was composed of pleomorphic spindle to polygonal cells arranged in fascicles and storiform structures with extensive necrosis. Twelve mitotic figures were noted in 10 high power fields. Immunohistochemical staining for vimentin and CD68 were positive whereas pan-cytokeratin, smooth muscle actin, S-100, HMB-45 and desmin were negative. “A pleomorphic type of malignant fibrous histiocytoma” was diagnosed based on both the microscopic and immunohistochemical findings. The patient presented with multiple bilateral lung metastasis three years after nephrectomy.Histopathological examination is essential since malignant fibrous histiocytoma cannot be differentiated clinically and radiologically from other lesions with kidney involvement. The overall prognosis is unfavorable with a recurrence rate of more than 50% and the 5-yearsurvival rate is only 14%.

Nilay ?EN TÜRK; Canan KELTEN; Nihal ÖZKALAY ÖZDEM?R; Ender DÜZCAN

2010-01-01

171

The CT and F-FDG PET/CT appearance of Primary renal malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Full text: Renal malignant fibrous histiocytoma (MFH) is a rare, primary renal tumour. Imaging findings of renal MFH, including ultrasound, CT and MRI, have, however, been reported. As to the best of our knowledge 18F-FDG PETjCT imaging of renal MFH has not been previously reported, we present the CT and 18F-FDG PETjCT appearance of a pathologically proven primary renal MFH.

2010-01-01

172

Successful management of a recurrent primary malignant fibrous histiocytoma of the lung: report of a case.  

UK PubMed Central (United Kingdom)

We describe herein an extremely rare case of a recurrent primary pulmonary malignant fibrous histiocytoma 3 months after operation that occurred in a 55-year-old man who was treated with chemotherapy and radiotherapy successfully. Until now, 36 months later, the patient has shown no evidence of tumor recurrence. The clinical, radiographic, and pathologic features are reported here together with a brief review of the literature.

Jeon YH; Park KS

2012-10-01

173

Malignant fibrous histiocytoma arising from a hydronephrotic kidney: a case report and review of the literature.  

UK PubMed Central (United Kingdom)

Primary malignant fibrous histiocytoma (MFH) is extremely rare, and MFH arising from a hydronephrotic kidney has not been reported. When MFH originates from a long-standing hydronephrotic kidney, the imaging findings can include nearly invisible renal parenchyma and atrophy of the ureter and renal artery, in addition to the findings attributable to the MFH, and the MFH with hydronephrosis may be confused with a cystic renal cell carcinoma.

Kim KH; Lee SH; Cha SH; Kim YS; Sung DJ

2012-05-01

174

Primary malignant fibrous histiocytoma involving the left pulmonary vein presenting as a left atrial tumor.  

UK PubMed Central (United Kingdom)

A 35-year-old woman presented with 4 months history of progressively increasing intermittent dyspnea and hemoptysis. Transthoracic echocardiography revealed a loculated mass in the left atrium (LA). A provisional diagnosis of LA myxoma was made. Intraoperatively the tumor was found extending into and closely adherent to the left pulmonary vein and could not be completely cleared off from the pulmonary venous wall. The histopathological examination of the tumor revealed it to be a myxoid malignant fibrous histiocytoma.

Bandyopadhyay S; Banerjee S; Paul A; Das RK

2013-10-01

175

Nuclear magnetic resonance studies on malignant fibrous histiocytoma. Evaluation of the effectiveness of chemotherapy in anticancer drug  

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The relaxation times of water protons in the tissues of malignant fibrous histiocytoma (MFH) and the tumor treated with adriamycin (adriamycin-treated MFH) were studied in rats as a model of human MFH by nuclear magnetic resonance. Using the values of the malignancy index derived from the relaxation times of these tumors, it has been possible to discriminate clearly between MFH tissue and non-malignant tissue, and to evaluate the effectiveness of anticancer drug. The malignancy index, furthermore, was compatible with the histological evaluation of the effectiveness of chemotherapy in an adriamycin-treated malignant fibrous histiocytoma.

Shimomura, Yoshifumi; Yamasaki, Masaki

1987-12-01

176

A case of malignant fibrous histiocytoma following radiation therapy for superior sulcus tumor  

International Nuclear Information System (INIS)

We recently observed a case of presumed radiation-induced malignant fibrous histiocytoma (MFH), which developed 20 years after radiation therapy (74 Gy) for superior sulcus tumor. The radiation-induced brachial plexopathy occurred 10 years after completion of radiation therapy. The evolution of multimodality management for superior sulcus tumor increases the number of long-term surviving cases, the incidence of irradiation-induced secondary malignant tumor will increase. It is therefore necessary to survey these cases over a long period of time after radiation therapy. (author)

2008-01-01

177

Malignant fibrous histiocytoma following radiation therapy and chemotherapy for Hodgkin's lymphoma  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma (MFH) originates from primitive mesenchymal cells and has the capacity for dual differentiation into histiocytes and fibroblasts. MFH occurring as a secondary malignancy following radiochemotherapy is rare and its exact incidence is not yet known. Here we report a case of a 42-year-old man who developed MFH in his right knee over a period of more than 10 years after radio (44 Gy)-chemotherapy to treat Hodgkin's lymphoma. After the diagnosis the patient did not return and was lost to follow-up. This is a rare case with unusual presentation, and it highlights the importance of the awareness and prevention of such secondary tumors. (author)

2007-01-01

178

Bone and gallium scan findings in malignant fibrous histiocytoma. Case report with radiographic and pathologic correlation  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma (MFH) is the most common soft tissue malignancy in adults. The Ga-67 citrate scan findings of an extremity-located MFH, the most common location of this neoplasm, have never been published in English language journals to the best of the authors' knowledge. Ga-67 citrate and Tc-99m MDP scans of the thigh mass accurately depicted the tumor's local extent, including the presence of central ischemic necrosis within the tumor, and the absence of adjacent osseous involvement and distant metastases, as correlated with computed tomography, angiography, and pathologic examinations

1987-01-01

179

Bone and gallium scan findings in malignant fibrous histiocytoma. Case report with radiographic and pathologic correlation  

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Malignant fibrous histiocytoma (MFH) is the most common soft tissue malignancy in adults. The Ga-67 citrate scan findings of an extremity-located MFH, the most common location of this neoplasm, have never been published in English language journals to the best of the authors' knowledge. Ga-67 citrate and Tc-99m MDP scans of the thigh mass accurately depicted the tumor's local extent, including the presence of central ischemic necrosis within the tumor, and the absence of adjacent osseous involvement and distant metastases, as correlated with computed tomography, angiography, and pathologic examinations.

Mackey, J.K.; Alexieva-Jackson, B.; Fetters, D.V.; Edwards, S.M.; McBride, J.P.; Cole, R.L.; Trapp, W.G.

1987-01-01

180

CERVICAL ANGIOMATOID FIBROUS HISTIOCYTOMA  

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Full Text Available Background: Angiomatoid fibrous histiocytoma (AFH) is a rare type of sarcoma with low-grade malignancy that usually occurs in young subjects. AFH is uncommon in the head and neck region.Methods: We describe an exceptional case of localization in the neck. This is the first report of a rare variant of AFHpresenting in a 42-year-old woman. The tumor was situated posterior to the carotid artery adhering to the prevertebral plane and invading the sympathetic cervical chain. In this setting, we decided to perform a surgical exploration with frozen section biopsy. The frozen section revealed a fusiform tumor proliferation resembling a sarcoma. A FISH study concluded on the presence of a EWSR1 22q (22) gene rearrangement. Furthermore, the immunohistochemical studyrevealed anti-EMA positive cells. The final pathological description concluded on the presence of an AFH, which wasexcised by surgery alone.Results: After a 2 year follow-up period, the patient is free of disease. Angiomatoid fibrous histiocytoma (AFH) is arare sarcoma subtype, and mis diagnosis can lead to its over treatment. A precise description of the pathologicalresponse and a multidisciplinary discussion can lead to a correct decision.Conclusion: AFH is a tumor with local evolution, and surgery is the mainstay of its management. Complete localexcision is recommended to hamper local recurrences.

Mohammad Al Felasi; Joao Barosa; Sebestian Arnaud; Marc Makeieff

2012-01-01

 
 
 
 
181

Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature  

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Full Text Available Abstract Background A malignant fibrous histiocytoma is a soft tissue tumor that most commonly occurs in the extremities, but rarely involves the liver. The clinical characteristics and therapeutic experiences of primary hepatic malignant fibrous histiocytoma are still limited. Methods Two cases of primary hepatic malignant fibrous histiocytoma were analyzed retrospectively, and all the literature concerning primary hepatic malignant fibrous histiocytoma was analyzed. Results In China, a total of 76 cases had been reported, among which 50 were men, with a male to female ratio of 1.9:1. Mean age of the patients was 51.0 years old, and more than 85 percent were older than 40 years. 82.9 percent (63/76) of hepatic MFH were solitary lesions, with tumor size ranging from 2.5 to 23.5 cm (average 10.3 cm). Major clinical presentation (78.4%) was abdominal pain or discomfort, accompanied with some other non-specific symptoms such as malaise, anorexia, weight loss, jaundice and fever, and small cases (14.9%) were asymptomatic. Computed tomography and ultrasound usually revealed the location of lesions. The rate of pre-operative misdiagnosis was extremely high, and 14.9 percent of patients were even misdiagnosed as a benign liver cyst, liver abscess or hematoma. Integrated resection was performed among the most cases (49/68), among which only a few ones (12 cases) were introduced to have no recurrence or metastasis or be still alive with no detail information provided, while among the cases with palliative operation or only a biopsy, the cases that were followed-up all died. Conclusions Hepatic malignant fibrous histiocytoma is a rare malignant mesenchymal tumor. The variable features of clinical presentations and images make the diagnosis difficult. Though the prognosis of primary hepatic malignant fibrous histiocytoma was rather poor, integrated resection might provide a few cases a good opportunity for surviving, suggesting that surgery might be an effective treatment.

Yao Dianbo; Dai Chaoliu

2012-01-01

182

Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature.  

UK PubMed Central (United Kingdom)

BACKGROUND: A malignant fibrous histiocytoma is a soft tissue tumor that most commonly occurs in the extremities, but rarely involves the liver. The clinical characteristics and therapeutic experiences of primary hepatic malignant fibrous histiocytoma are still limited. METHODS: Two cases of primary hepatic malignant fibrous histiocytoma were analyzed retrospectively, and all the literature concerning primary hepatic malignant fibrous histiocytoma was analyzed. RESULTS: In China, a total of 76 cases had been reported, among which 50 were men, with a male to female ratio of 1.9:1. Mean age of the patients was 51.0 years old, and more than 85 percent were older than 40 years. 82.9 percent (63/76) of hepatic MFH were solitary lesions, with tumor size ranging from 2.5 to 23.5 cm (average 10.3 cm). Major clinical presentation (78.4%) was abdominal pain or discomfort, accompanied with some other non-specific symptoms such as malaise, anorexia, weight loss, jaundice and fever, and small cases (14.9%) were asymptomatic. Computed tomography and ultrasound usually revealed the location of lesions. The rate of pre-operative misdiagnosis was extremely high, and 14.9 percent of patients were even misdiagnosed as a benign liver cyst, liver abscess or hematoma. Integrated resection was performed among the most cases (49/68), among which only a few ones (12 cases) were introduced to have no recurrence or metastasis or be still alive with no detail information provided, while among the cases with palliative operation or only a biopsy, the cases that were followed-up all died. CONCLUSIONS: Hepatic malignant fibrous histiocytoma is a rare malignant mesenchymal tumor. The variable features of clinical presentations and images make the diagnosis difficult. Though the prognosis of primary hepatic malignant fibrous histiocytoma was rather poor, integrated resection might provide a few cases a good opportunity for surviving, suggesting that surgery might be an effective treatment.

Yao D; Dai C

2012-01-01

183

Malignant fibrous histiocytoma of the head and neck: a case series.  

UK PubMed Central (United Kingdom)

PURPOSE: The study objective is to evaluate the clinical features and outcomes of patients treated for head and neck malignant fibrous histiocytoma at a tertiary care medical facility. MATERIALS AND METHODS: This is a retrospective case series of 17 adult subjects with malignant fibrous histiocytoma of the head and neck who were treated between January 1, 1965, and December 31, 2010. This study was conducted using patient charts at a tertiary medical center. Subject selection was conducted using Current Procedural Terminology numbers; International Classification of Diseases, Ninth Revision, codes; and a search of the tumor registry. RESULTS: Chart review of the 17 identified subjects revealed an overwhelming male predominance (88%) with an overall mean age of 69 years(52-87 years). Thirteen patients (78%) underwent some form of surgical resection, 6 patients (35%) received radiation therapy, and 6 (35%) were given chemotherapy over the course of treatment. Nine tumors (53%) had a cutaneous origin, whereas 8 lesions (47.1%) were found in the soft tissue of the head and neck region. The local recurrence rate following a single resection was 46%. Overall median survival following diagnosis was found to be 65 months, with a 5-year survival rate of 52%. Median disease-free survival was 20 months, with a 5-year disease-free survival rate of 37%. Overall median and 5-year survival rates were found to increase with clear surgical margins, as was 5-year survival. CONCLUSIONS: Aggressive surgical management to achieve clear margins is central to the effective treatment of malignant fibrous histiocytoma of the head and neck. Metastatic disease portends a dismal prognosis.

Hardison SA; Davis PL 3rd; Browne JD

2013-01-01

184

Radiological findings of primary abdominal malignant fibrous histiocytoma : emphasis on CT findings  

International Nuclear Information System (INIS)

To evaluate the radiological findings of abdominal malignant fibrous histiocytomas We retrospectively reviewed the radiological findings of 13 masses in seven patients including two patients with multiple masses. The masses were located at the mesentery and omentum in three patients and at the retroperitoneum in four. Gastrointestinal examination using barium was performed in four patients, ultrasonography in five and computed tomography in all. The average diameter of masses was 7.8cm(range:1-20cm);plain abdominal films revealed soft tissue masses in all patients. Three of four barium studies demonstrated only displacement of bowel loops and the other showed findings of submucosal tumor. Eight of 11 masses were detected on ultrasonography and all were round or lobulated and had well defined margins. Four of these masses were greater than 8cm in diameter and showed homogeneous echogenicity with central hypo or anechoic area;the remaining were less than 8cm and showed relatively homogeneous echogenicity. On computed tomography, all 13 masses were seen as highly enhanced and well circumscribed. Seven were greater than 5cm in diameter and had internal low-density areas. Peritumoral vessel-like structures were seen in eight masses and on plain abdominal radiograph and computed tomogram, calcification was seen in one patient. In no patient was combined retroperitoneal or intraperitoneal lymphadenopathy noted. Abdominal malignant fibrous histiocytomas are well-circumscribed, round or lobulated bulky masses with frequent necrosis and occasional calcification. Characteristically, there is no combined lymphadenopathy and multiple masses are a rare manifestation. These findings may be helpful in the diagnosis of malignant fibrous histiocytoma

1996-01-01

185

Endobronchial malignant fibrous histiocytoma: case report of an unusual presentation and palliative flexible bronchoscopic resection.  

Science.gov (United States)

Primary malignant fibrous histiocytoma (MFH) of the lung is a very rare neoplasm that usually presents as a parenchymal mass. Here we report an unusual case of primary MFH of the bronchus, showing relatively benign clinical features. We performed a palliative resection via flexible bronchoscopy, using a polypectomy snare. The patient has survived for over 2 years after being diagnosed with an endobronchial mass, later found to be MFH, and 14 months post-debulking. There is a possibility that endobronchial MFH has a more favorable prognosis than MFH of other origins. If this is true, interventional bronchoscopy can be a reasonable option for non-operable cases of MFH. PMID:23258577

Kim, Jung-Hyun; Cho, Sang-Ho; Kim, Eun-Kyung; Lee, Ji-Hyun; Jeong, Hye-Cheol

2012-12-18

186

Imaging Findings of Malignant Fibrous Histiocytoma of the Breast: A Case Report  

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A malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma encountered during adulthood, but the breast is not a common site of involvement for MFH. Several investigators have reported the histopathological and biological features of a MFH involving the breast, but only a few reports have focused on the imaging findings of breast MFHs. To emphasize the importance of arriving at a preoperative diagnosis for the treatment implications, we report here the imaging findings, including the mammography, US and MRI findings, for a MFH of the breast of a 53-year-old woman who presented with a rapid growing huge mass in the right breast.

Kim, Ji Na; Kook, Shin Ho; Kwag, Hyoun Joo; Choi, Yoon Jung; Sohn, Jin Hee; Park, Yong Lai [Kangbuk Samsung Hospital, Seoul (Korea, Republic of); Kim, Jin Hyo [You and Me Surgery, Jeonju (Korea, Republic of)

2010-03-15

187

Primary intracerebral malignant fibrous histiocytoma: CT, MRI, and PET-CT findings.  

Science.gov (United States)

Primary intracranial malignant fibrous histiocytoma (MFH) is an extremely rare entity. A few reported cases have been associated with factors such as a previous history of radiation therapy or surgical trauma. We report on a rare case of intracerebral MFH in a previously healthy 47-year-old man, which was initially presumed to be a high-grade glioma. Conventional as well as advanced magnetic resonance sequences, including diffusion-weighted image and perfusion-weighted image, were used in characterization of the mass. PMID:21447025

Yoo, Roh-Eul; Choi, Seung Hong; Park, Sung-Hye; Jung, Hee-Won; Kim, Ji-hoon; Sohn, Chul-Ho; Chang, Kee-Hyun

2011-03-29

188

A case of malignant fibrous histiocytoma of the pancreas: computed tomography (CT) and ultrasound (US) appearance  

International Nuclear Information System (INIS)

The case of a 50-year-old female with a malignant fibrous histiocytoma of the pancreas is presented. This was diagnosed pre-operatively on ultrasound and computed tomography (CT). The lesion encircled the body and tail of the pancreas and appeared as a large inhomogeneous mass with polycyclic and well-defined margins. Contrast-enhanced CT examination showed marked but inhomogeneous enhancement. The tomodensitometric characteristics plus the lack of lymphnodal or hepatic metastases indicated the sarcomatous nature of the mass before the surgical approach. (orig.)

1993-01-01

189

Imaging Findings of Malignant Fibrous Histiocytoma of the Breast: A Case Report  

International Nuclear Information System (INIS)

A malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma encountered during adulthood, but the breast is not a common site of involvement for MFH. Several investigators have reported the histopathological and biological features of a MFH involving the breast, but only a few reports have focused on the imaging findings of breast MFHs. To emphasize the importance of arriving at a preoperative diagnosis for the treatment implications, we report here the imaging findings, including the mammography, US and MRI findings, for a MFH of the breast of a 53-year-old woman who presented with a rapid growing huge mass in the right breast

2010-01-01

190

Primary intracerebral malignant fibrous histiocytoma: CT, MRI, and PET-CT findings.  

UK PubMed Central (United Kingdom)

Primary intracranial malignant fibrous histiocytoma (MFH) is an extremely rare entity. A few reported cases have been associated with factors such as a previous history of radiation therapy or surgical trauma. We report on a rare case of intracerebral MFH in a previously healthy 47-year-old man, which was initially presumed to be a high-grade glioma. Conventional as well as advanced magnetic resonance sequences, including diffusion-weighted image and perfusion-weighted image, were used in characterization of the mass.

Yoo RE; Choi SH; Park SH; Jung HW; Kim JH; Sohn CH; Chang KH

2013-01-01

191

Endobronchial malignant fibrous histiocytoma: case report of an unusual presentation and palliative flexible bronchoscopic resection.  

UK PubMed Central (United Kingdom)

Primary malignant fibrous histiocytoma (MFH) of the lung is a very rare neoplasm that usually presents as a parenchymal mass. Here we report an unusual case of primary MFH of the bronchus, showing relatively benign clinical features. We performed a palliative resection via flexible bronchoscopy, using a polypectomy snare. The patient has survived for over 2 years after being diagnosed with an endobronchial mass, later found to be MFH, and 14 months post-debulking. There is a possibility that endobronchial MFH has a more favorable prognosis than MFH of other origins. If this is true, interventional bronchoscopy can be a reasonable option for non-operable cases of MFH.

Kim JH; Cho SH; Kim EK; Lee JH; Jeong HC

2013-08-01

192

Fibro-histiocitoma maligno da pálpebra: relato de caso Malignant fibrous histiocytoma of the eyelid: case report  

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Full Text Available Os fibro-histiocitomas representam 1% das massas orbitárias e podem ser histologicamente classificados em benignos, localmente agressivos e malignos - os últimos representando aproximadamente 11% do total. Nesse estudo, os autores descrevem um caso raro de fibro-histiocitoma maligno de pálpebra, ressaltando as características clínicas e histopatológicas desta neoplasia.Fibrous histiocytomas represent 1% of all orbital masses and may be classified into benign, locally aggressive and malignant - these representing nearly 11% of the total. In this study, the authors describe an unusual case of malignant fibrous histiocytoma of the eyelid, discussing clinical and histological features of this neoplasm.

Ana Carolina Toledo Dias; Luciano de Sousa Pereira; Lílian Midori Sameshima; Frederico Augusto Costa Reis; José Vital Filho

2009-01-01

193

Fibro-histiocitoma maligno da pálpebra: relato de caso/ Malignant fibrous histiocytoma of the eyelid: case report  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Os fibro-histiocitomas representam 1% das massas orbitárias e podem ser histologicamente classificados em benignos, localmente agressivos e malignos - os últimos representando aproximadamente 11% do total. Nesse estudo, os autores descrevem um caso raro de fibro-histiocitoma maligno de pálpebra, ressaltando as características clínicas e histopatológicas desta neoplasia. Abstract in english Fibrous histiocytomas represent 1% of all orbital masses and may be classified into benign, locally aggressive and malignant - these representing nearly 11% of the total. In this study, the authors describe an unusual case of malignant fibrous histiocytoma of the eyelid, discussing clinical and histological features of this neoplasm.

Dias, Ana Carolina Toledo; Pereira, Luciano de Sousa; Sameshima, Lílian Midori; Reis, Frederico Augusto Costa; Vital Filho, José

2009-02-01

194

Imaging findings, prevalence and outcome of de novo and secondary malignant fibrous histiocytoma of bone  

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To evaluate the radiographic and magnetic resonance (MR) imaging features of primary and secondary malignant fibrous histiocytoma in bone and determine the demographics, prevalence and outcome of patients with this tumor. A retrospective search of files from two institutions identified 28 patients with malignant fibrous histiocytoma (MFH) of bone. Microscope slides were reviewed to confirm diagnosis and identify any pre-existing lesions. Medical records were reviewed with respect to patients' demographic characteristics and outcomes. Radiographic features demonstrated an aggressive osteolytic lesion with a permeative pattern of bone destruction. Periosteal reaction was seen in three of 13 lesions. T1-weighted images (T1WIs) demonstrated signal intensity iso- to slightly hyperintense to muscle. T2-weighted images (T2WIs) demonstrated mildly higher signal intensity than that of muscle. The 5-year survival rate was 53%. The tumor arose secondarily in pre-existing lesions in 43% of patients. Metastases occurred in 46% of patients during the course of the disease, with pulmonary and osseous metastases being the most common. Secondary MFH of bone was slightly less common than primary MFH and had a prognosis similar to that of primary MFH of bone. MR imaging showed variable and somewhat unusual low to intermediate T2 signal characteristics for a radiographically malignant osteolytic lesion. (orig.)

Koplas, Monica C.; Ilaslan, Hakan; Sundaram, Murali [Cleveland Clinic, Imaging Institute/A21, Cleveland, OH (United States); Lefkowitz, Robert A.; Landa, Jonathan [Memorial Sloan-Kettering Cancer Center, Department of Radiology, New York, NY (United States); Bauer, Thomas W. [Cleveland Clinic, Anatomic Pathology/L25, Cleveland, OH (United States); Joyce, Michael J. [Cleveland Clinic, Orthopaedic and Rheumatologic Institute/A41, Cleveland, OH (United States)

2010-08-15

195

Imaging findings, prevalence and outcome of de novo and secondary malignant fibrous histiocytoma of bone  

International Nuclear Information System (INIS)

To evaluate the radiographic and magnetic resonance (MR) imaging features of primary and secondary malignant fibrous histiocytoma in bone and determine the demographics, prevalence and outcome of patients with this tumor. A retrospective search of files from two institutions identified 28 patients with malignant fibrous histiocytoma (MFH) of bone. Microscope slides were reviewed to confirm diagnosis and identify any pre-existing lesions. Medical records were reviewed with respect to patients' demographic characteristics and outcomes. Radiographic features demonstrated an aggressive osteolytic lesion with a permeative pattern of bone destruction. Periosteal reaction was seen in three of 13 lesions. T1-weighted images (T1WIs) demonstrated signal intensity iso- to slightly hyperintense to muscle. T2-weighted images (T2WIs) demonstrated mildly higher signal intensity than that of muscle. The 5-year survival rate was 53%. The tumor arose secondarily in pre-existing lesions in 43% of patients. Metastases occurred in 46% of patients during the course of the disease, with pulmonary and osseous metastases being the most common. Secondary MFH of bone was slightly less common than primary MFH and had a prognosis similar to that of primary MFH of bone. MR imaging showed variable and somewhat unusual low to intermediate T2 signal characteristics for a radiographically malignant osteolytic lesion. (orig.)

2010-01-01

196

A rare presentation of hepatic and splenic cystic malignant fibrous histiocytoma: A case report and literature review.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in late adult life. But primary visceral malignant fibrous histiocytoma is a very rare entity. In peripheries, it is known to have an aggressive behavior but its biological pattern when involving liver and spleen is not well understood due to the rarity of its occurrence. PRESENTATION OF CASE: A case of malignant fibrous histiocytoma of the liver and spleen as multiple cystic lesions in a 30 years old man is reported. The patient presented with hepatosplenomegaly resulting in central abdominal distention. Pre-operative investigations pointed toward the diagnosis of malignant cystic disease. The tumor presented as multiple hepatic cysts with massive hepatomegaly and splenomegaly. These cysts contained hemorrhagic fluid. Biopsy revealed highly cellular pleomorphic spindle cells fascicles arranged in storiform pattern at places with frequent mitoses. Immunohistochemistry revealed viamentin positivity. The tumor is compared with previous case reports. DISCUSSION: Malignant fibrous histiocytoma of liver and spleen has been mentioned in the literature as isolated case reports and most of these present as solid lesions but presentation as multiple cysts is also a possibility as was seen in this patient. It can be confirmed only on histo-pathology supported by immunohistochemistry. The disease carries guarded prognosis due to its rapid progression and diagnostic dilemma pre-operatively. CONCLUSION: This rare malignancy affecting the viscera can be diagnosed only with high index of suspicion and awareness regarding its presentation can help surgeons deal with it.

Das A; Arya SV; Soni N; Gowda GG; Kalwaniya DS

2013-01-01

197

A malignant fibrous histiocytoma after radical mastectomy with radiotherapy. A case report  

International Nuclear Information System (INIS)

A rare case of radiation induced malignant fibrous histiocytoma is presented. A 57-year-old woman noticed a rapidly enlarging tumor with itch in the left supraclavicular region and visited another hospital. There was a previous history of undergoing a radical mastectomy with radiotherapy for a left breast cancer at elsewhere (no clear information on clinical stage and dose of radiation was obtained). The patient was referred to the hospital. On admission a 10 x 8 cm tumor in the left supraclavicular region was noted. The tumor had lobulated surface to bleed easily and fixed to the clavicle. Thoracic CT and MRI revealed a hypervascular tumor destroying the clavicle. Angiography showed keterogenous vascularity of the tumor vis the transverse and ascending cervical arteries. We carried out wide resection of the tumor with the clavicle and reconstructed with a left lattisimus dorsi flap. Since the tumor was composed of atypical fibroblasts and histiocytes. It was diagnosed as radiation induced malignant fibrous histiocytoma. After operation, inflammation of the flap and dyskinesia of the left upper extremity occurred, but were managed conservatively. There has been no sign of recurrence as of 2 years and 8 months after the operation. (author)

1996-01-01

198

A malignant fibrous histiocytoma after radical mastectomy with radiotherapy. A case report  

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A rare case of radiation induced malignant fibrous histiocytoma is presented. A 57-year-old woman noticed a rapidly enlarging tumor with itch in the left supraclavicular region and visited another hospital. There was a previous history of undergoing a radical mastectomy with radiotherapy for a left breast cancer at elsewhere (no clear information on clinical stage and dose of radiation was obtained). The patient was referred to the hospital. On admission a 10 x 8 cm tumor in the left supraclavicular region was noted. The tumor had lobulated surface to bleed easily and fixed to the clavicle. Thoracic CT and MRI revealed a hypervascular tumor destroying the clavicle. Angiography showed keterogenous vascularity of the tumor vis the transverse and ascending cervical arteries. We carried out wide resection of the tumor with the clavicle and reconstructed with a left lattisimus dorsi flap. Since the tumor was composed of atypical fibroblasts and histiocytes. It was diagnosed as radiation induced malignant fibrous histiocytoma. After operation, inflammation of the flap and dyskinesia of the left upper extremity occurred, but were managed conservatively. There has been no sign of recurrence as of 2 years and 8 months after the operation. (author)

Suzuki, Yasuhiro; Tokuda, Yutaka; Kimura, Tomihiko; Tajima, Tomoo; Mitomi, Toshio; Osamura, Yoshiyuki [Tokai Univ., Isehara, Kanagawa (Japan). School of Medicine

1996-12-01

199

Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients  

International Nuclear Information System (INIS)

Among the 130 primary or secondary malignant fibrous histiocytomas of bone diagnosed and treated at Memorial Hospital for Cancer and Allied Diseases during the previous half century, 20 (15.4%) arose as a direct consequence of irradiation. This type is the commonest secondary osseous malignant fibrous histiocytoma at this institution. It affects the ilium, the scapula, and the distal end of the femur most frequently, predominantly in patients whose age peaks in the fifth decade of life, when their sarcomas developed. Grounds for the irradiation were either nonosseous conditions (13 patients) or preexistent skeletal lesions (seven patients). Reasons for the incidental bone irradiation included Hodgkin's disease; carcinoma of cervix, breast, or lung; bilateral retinoblastoma, and others; giant cell tumors predominated among the irradiated skeletal lesions. The mean and the median radiation doses were 6,040 and 5,700 rads, respectively. The latent period between irradiation and the appearance of the bone sarcoma ranged from 4 to 47 years with a mean of 16.5 and a median of 14.5 years, respectively. The cumulative disease-free survival rate at 3 years was 58%. Although all patients who received their radiation therapy for a preexistent bone lesion survived, only 27% of patients whose bone was normal at the time of irradiation are alive and well at the 3-year mark

1986-01-01

200

An 11 kg Malignant Fibrous Histiocytoma in a 54-Year-Old Patient: A Case Report  

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Full Text Available Background and Objectives: Malignant fibrous histiocytoma (MFH) is a soft tissue sarcoma of undifferentiated mesenchymal cell origin which is considered the most common soft tissue sarcoma in adults. It commonly occurs in the 5th and 6th decades with a 2-to-1 male to female ratio. It most frequently occurs in the extremities and retroperitoneum. Most of it is derived from soft tissues and some of it from bone tissue. In this study, we introduce a patient who had MFH in retroperitoneal area and at the time of diagnosis the tumor size and weight had reached a significant level. Case Report: The patient is a 54-year-old male that referred to the hospital with complaints of pain and fullness in the abdomen. His pain had started from two years ago and had been accompanied with early satiation, bloating, weight gain and hypertension. On physical examination, asymmetric enhancement was visible. After diagnosis of mass and investigation of its development in abdomen and pelvic with CTscan, the patient was underwent operation and a mass with about 11kg of weigh was resected. During pathologic investigation, high grade spindle cell sarcoma and malignant fibrous histiocytoma were reported. After resection of tumor, the abdominal pain of patient disappeared and additionally his blood pressure came back to normal levels.  

M.R Ghadir

2012-01-01

 
 
 
 
201

Primary malignant fibrous histiocytoma of the breast: report of one case  

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Full Text Available Caigang Liu,1 Zuowei Zhao,1 Qingfu Zhang,2 Yunfei Wu,3 Feng Jin3 1Department of Breast Surgery, Second Hospital of Dalian Medical University, Dalian, People's Republic of China; 2Department of Pathology, First Hospital of China Medical University, Shenyang, People's Republic of China; 3Department of Breast Surgery, General Surgery, First Hospital of China Medical University, Shenyang, People's Republic of China. Abstract: Seven years ago, a 48-year-old female patient discovered a painless tumor in her right breast simply by chance. In the next year, the tumor increased significantly in size. At this point, the patient received a tumor resection, which was misdiagnosed as a benign mesenchymal tissue-originated tumor. Unfortunately, the tumor recurred just 10 days after resection. We subsequently resected the recurrent lesion and confirmed primary breast malignant fibrous histiocytoma. The tumor began to exhibit an unprecedented, massive, and uncontrolled growth, ulcerating soon after the operation. Treatment of the patient was limited by time. After the patient received a cycle of chemotherapy, she died of cachexia with the emergence of multiorgan metastasis 2 months after the operation. Keywords: breast, primary malignant fibrous histiocytoma, treatment, survival

Liu C; Zhao Z; Zhang Q; Wu Y; Jin F

2013-01-01

202

An 11 kg Malignant Fibrous Histiocytoma in a 54-Year-Old Patient: A Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Objectives: Malignant fibrous histiocytoma (MFH) is a soft tissue sarcoma of undifferentiated mesenchymal cell origin which is considered the most common soft tissue sarcoma in adults. It commonly occurs in the 5th and 6th decades with a 2-to-1 male to female ratio. It most frequently occurs in the extremities and retroperitoneum. Most of it is derived from soft tissues and some of it from bone tissue. In this study, we introduce a patient who had MFH in retroperitoneal area and at the time of diagnosis the tumor size and weight had reached a significant level.Case Report: The patient is a 54-year-old male that referred to the hospital with complaints of pain and fullness in the abdomen. His pain had started from two years ago and had been accompanied with early satiation, bloating, weight gain and hypertension. On physical examination, asymmetric enhancement was visible. After diagnosis of mass and investigation of its development in abdomen and pelvic with CTscan, the patient was underwent operation and a mass with about 11kg of weigh was resected. During pathologic investigation, high grade spindle cell sarcoma and malignant fibrous histiocytoma were reported. After resection of tumor, the abdominal pain of patient disappeared and additionally his blood pressure came back to normal levels.

Ghadir M.R; Sarkeshikian S; Amjadi M.R; Ghanooni A.H; Khan Ahmadi N

2011-01-01

203

Adrenal metastases in a post-radiation malignant fibrous histiocytoma after low-dose radiation for a benign condition.  

Science.gov (United States)

A 29-year-old male presented with an aggressive malignant fibrous histiocytoma of his leg 14 years after he had received low-dose radiation to the area for a benign indication. The other unusual feature of this case was the large unilateral adrenal metastasis. We describe this very rare presentation of sarcoma and briefly review the relevant literature. PMID:23878485

Ganesan, Prasanth; Kaushal, Seema; Thulkar, Sanjay; Bakhshi, Sameer

2013-01-01

204

Pseudoaneurysm and ilio-caval fistula caused by malignant fibrous histiocytoma of the aorta - CT diagnosis and angiographic confirmation  

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We report a case of a malignant fibrous histiocytoma (MFH) of the aortic bifurcation, which manifested as a pseudoaneurysm with the formation of an ilio-caval fistula, a complication about which, to our knowledge, nothing has been published previously. Spiral CT, catheter arteriography and venography were complementary in the diagnostic procedure. (orig.)

Szucs-Farkas, Zsolt; Toth, Judit; Peter, Mozes [Department of Radiology, University of Debrecen, Medical and Health Science Center, Debrecen (Hungary); Szollosi, Zoltan [Department of Pathology, University of Debrecen, Medical and Health Science Center, Debrecen (Hungary)

2002-02-01

205

CT and MRI findings with pathological correlation of an intracerebral malignant fibrous histiocytoma (MFH): a case report  

International Nuclear Information System (INIS)

The CT and MRI findings in a case of an intracranial malignant fibrous histiocytoma are reported. Pathological correlation was demonstrated and tumour vascularization was best seen at angiography. Despite its low incidence in brain, MFH is of special interest because of its ubiquitous location and poor prognosis. (orig.)

1996-01-01

206

Pseudoaneurysm and ilio-caval fistula caused by malignant fibrous histiocytoma of the aorta - CT diagnosis and angiographic confirmation  

International Nuclear Information System (INIS)

We report a case of a malignant fibrous histiocytoma (MFH) of the aortic bifurcation, which manifested as a pseudoaneurysm with the formation of an ilio-caval fistula, a complication about which, to our knowledge, nothing has been published previously. Spiral CT, catheter arteriography and venography were complementary in the diagnostic procedure. (orig.)

2002-01-01

207

Adrenal metastases in a post-radiation malignant fibrous histiocytoma after low-dose radiation for a benign condition.  

UK PubMed Central (United Kingdom)

A 29-year-old male presented with an aggressive malignant fibrous histiocytoma of his leg 14 years after he had received low-dose radiation to the area for a benign indication. The other unusual feature of this case was the large unilateral adrenal metastasis. We describe this very rare presentation of sarcoma and briefly review the relevant literature.

Ganesan P; Kaushal S; Thulkar S; Bakhshi S

2013-01-01

208

Malignant fibrous histiocytoma. Evidence of perivascular mesenchymal cell origin immunocytochemical studies with monoclonal anti-MFH antibodies.  

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Using whole cell antigens prepared from the established lines of human malignant fibrous histiocytoma (MFH), the authors have generated two different monoclonal antibodies (FU3 and FU4) by a mouse hybridoma technique. By indirect immunoperoxidase in frozen tissue sections, FU3 and FU4 revealed stron...

Iwasaki, H.; Isayama, T.; Johzaki, H.; Kikuchi, M.

209

Two Cases of Primary Malignant Fibrous Histiocytoma of the Liver: Immunohistochemical Expression of Ezrin and Its Relationship with Prognosis  

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Malignant fibrous histiocytoma (MFH) as soft tissue sarcoma would not be especially noteworthy, but primary hepatic MFH reports are extremely rare. Herein, we report ezrin expression in tumor tissues from two primary hepatic MFH cases with different prognoses. Cases 1 and 2 were both women, ages 45 ...

Sugitani, Masahiko; Aramaki, Osamu; Kikuchi, Kentaro; Sheikh, Aleemuzzaman; Oinuma, Toshinori; Mamiya, Takao; Takayama, Tadatoshi

210

A case of radiation-induced pelvic malignant fibrous histiocytoma 8 years after radiotherapy for uterus cervical cancer  

International Nuclear Information System (INIS)

A case of postradiation malignant fibrous histiocytoma of the pelvis was reported. The patient is a 79-year-old woman. She was treated by radiation for cervical cancer of the uterus 8 years ago. The problem of second cancer will be more important in cancer treatment. (author)

1991-01-01

211

CT and MRI findings with pathological correlation of an intracerebral malignant fibrous histiocytoma (MFH): a case report  

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The CT and MRI findings in a case of an intracranial malignant fibrous histiocytoma are reported. Pathological correlation was demonstrated and tumour vascularization was best seen at angiography. Despite its low incidence in brain, MFH is of special interest because of its ubiquitous location and poor prognosis. (orig.)

Berchtenbreiter, C.H.G. [Dept. of Diagnostic Radiology, University Clinic Grosshadern, Muenchen Univ. (Germany); Stehling, M.G. [Dept. of Diagnostic Radiology, University Clinic Grosshadern, Muenchen Univ. (Germany); Scheidler, J. [Dept. of Diagnostic Radiology, University Clinic Grosshadern, Muenchen Univ. (Germany); Bise, K. [Muenchen Univ. (Germany). Dept. of Neuropathology; Waidhauser, E. [Dept. of Neurosurgery, University Clinic Grosshadern, Muenchen Univ. (Germany); Reiser, M. [Dept. of Diagnostic Radiology, University Clinic Grosshadern, Muenchen Univ. (Germany)

1996-12-01

212

Malignant fibrous histiocytoma of the deep peri-articular tissue of the stifle in a dog : case report  

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A Belgian shepherd dog aged 4 years and 9 months was presented with acute onset of non-weight bearing lameness and stifle effusion of the left hind limb, caused by the deep form of a malignant fibrous histiocytoma originating in the deep musculature and fascia surrounding the stifle joint. The tumou...

M.J. Booth; S.S. Bastianello; M. Jiminez; A. Van Heerden

213

A new complication of retained surgical gauze: development of malignant fibrous histiocytoma – report of a case with a literature review  

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Abstract Background Primary visceral malignant fibrous histiocytoma (MFH) is a rare disease, and few cases have been reported in the English literature. However, retained foreign bodies in the abdomen after surgical procedures are important causes of intra-abdominal infections. For ...

Kaplan Mehmet; ?yikö?ker Halil

214

Retroperitoneal malignant fibrous histiocytoma: radiological aspects - a case report; Fibro-histiocitoma maligno retroperitoneal: aspectos radiologicos -relato de um caso  

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The authors present a retroperitoneal malignant fibrous histiocytoma case report that, although considered the most common soft tissue sarcoma in middle-aged adults, still represents a difficult diagnosis, rising a lot of doubt. It is emphasized the importance of computer tomography and magnetic resonance imaging in correlation with pathological aspects. (author). 6 refs, 7 figs.

Moreira, F.A.; Andrade, L.G.S.; Soares, A.S. [Hospital Nove de Julho, Sao Paulo, SP (Brazil). Servico de Radiologia

1995-01-01

215

Radiology and pathology of malignant fibrous histiocytomas of the soft tissues; a report of ten cases  

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Malignant fibrous histiocytomas (MFH) are believed to originate from histiocytes and are composed of malignant cells with spindle or round shapes. We evaluated ten MFH of the soft tissues by plain roentgenograms, computed tomography (CT), and angiography and subdivided them into four grades of anaplasia and five predominant histologic variants. The variants of MFH demonstrated different vascular patterns. The extension of the lesions could be determinded by CT and angiography. CT is the method of choice in the assessment of size and extent of MFH of the soft tissues. When intra-arterial chemotherapy is indicated the angiograms obtained at each catheter placement may substitute CT in follow-up studies obviating additional diagnostic procedures.

Fischer, H.J.; Lois, J.F.; Gomes, A.S.; Mirra, J.M.; Deutsch, L.S.

1985-03-01

216

Radiology and pathology of malignant fibrous histiocytomas of the soft tissues a report of ten cases  

International Nuclear Information System (INIS)

Malignant fibrous histiocytomas (MFH) are believed to originate from histiocytes and are composed of malignant cells with spindle or round shapes. We evaluated ten MFH of the soft tissues by plain roentgenograms, computed tomography (CT), and angiography and subdivided them into four grades of anaplasia and five predominant histologic variants. The variants of MFH demonstrated different vascular patterns. The extension of the lesions could be determinded by CT and angiography. CT is the method of choice in the assessment of size and extent of MFH of the soft tissues. When intra-arterial chemotherapy is indicated the angiograms obtained at each catheter placement may substitute CT in follow-up studies obviating additional diagnostic procedures. (orig.)

1985-01-01

217

Malignant fibrous histiocytoma: outcome and prognostic factors following conservation surgery and radiotherapy  

International Nuclear Information System (INIS)

Purpose: Malignant fibrous histiocytoma is the most common type of soft tissue sarcoma. This communication presents an analysis of outcome and prognostic factors based on a retrospective review of patients with this disease treated by conservation surgery and radiotherapy. Methods and Materials: From 1966 to 1991, 271 consecutive patients with malignant fibrous histiocytoma were treated with conservation surgery and radiotherapy. The outcome with local control, metastatic relapse, and survival as end points was evaluated by univariate and multivariate statistics to delineate independently significant prognostic factors. Results: Postoperative radiation at a mean dose of 62.8 Gy was used in 195 patients and preoperative radiation at a mean dose of 50 Gy was used in 76 patients. At a median follow-up of 7.3 years, 123 patients (45%) developed disease relapse at some site. Fifty-seven (21%) developed local recurrence leading to an actuarial local relapse rate of 26% at 10 years, 83 (31%) developed metastatic relapse for a 10-year actuarial metastatic rate of 33%, and the 5-, 10-, and 15-year survival rates were 68, 60, and 46%, respectively. For local control, prior local recurrence (in 53 patients) was identified as an adverse factor, yielding a 10-year recurrence rate of 42% compared to 22% for 218 patients without prior disease (p 5 cm), and histology (myxoid vs. nonmyxoid) were not significant determinants of local outcome. For metastatic relapse, the major determinants of outcome were histology (myxoid vs. nonmyxoid) and tumor size. Myxoid tumors (59 patients) had a low metastatic propensity (13% 10-year metastatic rate) compared to nonmyxoid tumors (212 patients) (40% 10-year metastatic rate) (p 5 cm) were the only independent determinants of outcome. Conclusion: Malignant fibrous histiocytoma is a heterogeneous disease and its myxoid variant must be recognized as a distinct entity. Both variants are locally aggressive and require equally aggressive local therapy. Conservation surgery striving for negative margins with radiation therapy provides acceptable local control and is the treatment of choice for this disease. Patients with myxoid tumors do not require systemic therapy; patients with nonmyxoid disease exceeding 5 cm are at significant risk for metastases and the development of effective adjuvant treatment is an important research goal

1996-03-15

218

Myxoid Type of Malignant Fibrous Histiocytoma of the Maxillary Sinus: A Case Report  

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Full Text Available Introduction: Myxofibrosarcoma was originally described as the myxoid variant of Malignant Fibrous Histiocytoma (MFH), a high-grade and aggressive sarcoma, which is very uncommon in the head and neck region, with about 100 cases reported up to now. MFH occurring in the maxillary sinus is so rare that only 23 cases have been reported. We hereby report a case of myxofibrosarcoma in the maxillary sinus. Case Report: The case was a 54-year-old male with symptoms of toothache in the right posterior maxillary teeth, a swelling adjacent to maxillary molar region and symptoms of chronic maxillary sinusitis. In clinical examination, the teeth were sensitive to percussion and palpation, but no caries and restoration was detected on his molar teeth. He was suffering from local pain and tenderness over his midface and mild fever, fatigue and some nonspecific vague pain. CT scan showed a mass lesion involving right nasal cavity, maxillary and ethmoidal sinuses. A low-grade malignancy arising from the right maxillary sinus was highly suspected. A surgery was done to remove the mass. The histological and immunohistochemical studies proved the diagnosis of myxoid variant of Malignant Fibrous Histiocytoma. Therefore radiotherapy and chemotherapy was started for the patient but six months later the symptoms returned and CT scan showed a right maxillary and ethmoidal mass that extended to base of the skull. Maxillectomy and ethmoidectomy were performed for the patient, but 2 months later he died because of the extension of the tumor, which confirmed the necessity of early diagnosis. Conclusion: Amplified radical surgery is the first choice of treatment. The second surgery has special value to the recurrent patients. Radiotherapy alone or chemotherapy alone is not effective to MFH of head and neck region

Amir Hossein Jafarian; Abbas Ali Omidi; Mohammad Mehdi Ghasemi; Bahareh Joushan

2011-01-01

219

Pleomorphic type of malignant fibrous histiocytoma with myxoid stroma of the vulva in a young woman.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma (MFH) of the vulva is extremely rare; to date, there have been nine case reports. Almost all of these cases involved middle-aged women. We encountered a 21-year-old woman with a 4.5 × 2.6 cm superficial, localized, exophytic tumor of the right vulva. Microscopic findings on punch biopsy of the tumor initially suggested a vulvar sarcoma. The patient underwent wide local excision of the vulva. The extirpated specimen demonstrated the pleomorphic type of MFH with myxoid stroma of the vulva. The clinical stage was found to be IIB, based on the American Joint Committee on Cancer staging system. Chromosomal analysis of the tumor using the conventional G-band method was normal (46XX). This seems to be a very rare case of MFH of the vulva in a young woman. Physicians should therefore include MFH in the differential diagnosis of vulvar tumors, even though it is a rare disease.

Iwakawa T; Tsuji T; Hamada T; Kamio M; Matsuo T; Yoshinaga M; Kitajima S; Douchi T

2011-10-01

220

Pleomorphic type of malignant fibrous histiocytoma with myxoid stroma of the vulva in a young woman.  

Science.gov (United States)

Malignant fibrous histiocytoma (MFH) of the vulva is extremely rare; to date, there have been nine case reports. Almost all of these cases involved middle-aged women. We encountered a 21-year-old woman with a 4.5 × 2.6 cm superficial, localized, exophytic tumor of the right vulva. Microscopic findings on punch biopsy of the tumor initially suggested a vulvar sarcoma. The patient underwent wide local excision of the vulva. The extirpated specimen demonstrated the pleomorphic type of MFH with myxoid stroma of the vulva. The clinical stage was found to be IIB, based on the American Joint Committee on Cancer staging system. Chromosomal analysis of the tumor using the conventional G-band method was normal (46XX). This seems to be a very rare case of MFH of the vulva in a young woman. Physicians should therefore include MFH in the differential diagnosis of vulvar tumors, even though it is a rare disease. PMID:21564409

Iwakawa, Tokiko; Tsuji, Takahiro; Hamada, Tomonori; Kamio, Masaki; Matsuo, Takashi; Yoshinaga, Mitsuhiro; Kitajima, Shinichi; Douchi, Tsutomu

2011-05-12

 
 
 
 
221

Malignant fibrous histiocytoma of bone: conventional X-ray and MR imaging features  

International Nuclear Information System (INIS)

Objective. To evaluate the conventional X-ray and MR imaging features of malignant fibrous histiocytoma (MFH) of bone. Design. MRI examinations and conventional radiographs were reviewed in 39 patients with biopsy-proven MFH. Imaging characteristics were analyzed and the differential diagnoses assessed in a masked fashion by two experienced radiologists. Results. Typical X-ray features included aggressive, destructive tumor growth centrally located in the metaphysis of long bones. Periosteal reactions and expansive growth were rarely seen. On MR images extraosseous tumor spread was frequently noted. On T2-weighted images and contrast-enhanced T1-weighted images most of the tumors displayed an inhomogeneous, nodular signal pattern with peripheral Gd-DTPA enhancement. Conclusions. Although several MR imaging criteria were typical for MFH none of them was specific. X-ray diagnosis of MFH may also prove difficult, with the main differential diagnosis being metastasis in the older and osteosarcoma in the younger population. (orig.)

1998-01-01

222

A Rare Type of Secondary Cancer in a Child With Acute Lymphoblastic Leukemia: Malignant Fibrous Histiocytoma.  

UK PubMed Central (United Kingdom)

Secondary cancers which are related with treatment of childhood acute lymphoblastic leukemia (ALL) is a significant problem with longer term. For development of secondary cancer after treatment, the latency period varies between 5 and 10 years. In this case, a 13 year-old-boy diagnosed as high-risk ALL was treated with chemotherapy and prophylactic cranial radiotherapy at a dose of 1800 cGy. Six years after the end of treatment he developed a 5×5×4 cm mass at the right temporal region of the cranium. The mass was excised totally with clear surgical margin. Pathology of mass has been diagnosed as malignant fibrous histiocytoma (MFH), recently referred to as an undifferentiated pleomorphic sarcoma (UPS). After treatment of childhood ALL, reported cases of secondary MFH is extremely rare in the literature. Herein we present a case of MFH/UPS that developed as a secondary cancer 6 years after the end of ALL treatment.

Incesoy Özdemir S; Balkaya E; Oren AC; Bozkurt C; Sahin G; Unlü RE; Ertem AU

2013-10-01

223

Malignant fibrous histiocytoma of the breast. A case report and review of the literature  

International Nuclear Information System (INIS)

The clinicopathologic features of a malignant fibrous histiocytoma arising in a female breast are presented. Seven cases have been previously reported. These may be divided into three subgroups based on history and pathologic findings. Three of the seven occurred in women without a history of other tumors or previous irradiation. One appeared with a cystosarcoma phyllodes, and three arose following radiation for carcinoma of the breast. The patient in this study had received no radiation. Treatment has been based on surgical resection; the roles of chemotherapy and radiation are uncertain. Although resection alone in the first subgroup has lead to no reported mortality, the small number of cases and the relatively short follow-up does not allow a meaningful assessment of the prognosis in this disease

1984-08-01

224

Primary malignant fibrous histiocytoma in mediastinum: Imaging with {sup 18}F FDG PET/CT  

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Malignant fibrous histiocytoma (MFH) is the most common soft tumor which often occurs in the extremities and the retroperitoneum. Pimary mediastinal MFH is rare; thus, findings on {sup 18}F fluorodeoxyglucose positron emission tomography/computed tomography ({sup 18}F FDG PET/CT) of mediastinal MFH have not been reported yet. We report herein the case of a 64 year old man who was presented with a superior mediastinal mass. the mass showed intense {sup 18}F FDG uptake with central metabolic defect on PET/CT the maximum standardized uptake value was 17.4. after tumor removal via median sternotomy, an MFH of the storiform pleomorphic type was diagnosed on histopathologic examination. We the first report of {sup 18}F FDG PET/CT imaging of MFH in the superior mediastinum.

Choi, Bong Hoi [Gyeongsang National Univ. Hospital, Jinju (Korea, Republic of); Yoon, Seok Ho; Lee, Sung Soo; Jo, Kyung Sook; Song, Hee Sung; An, Young Sil; Yoon, Joon Kee; Lee, Su Jin [Ajou Univ. School of Medicine, Suwon (Korea, Republic of)

2012-12-15

225

A case of malignant fibrous histiocytoma following postoperative irradiation for carcinoma of the cervix  

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We report a case of malignant fibrous histiocytoma (MFH) following carcinoma of the cervix. A 28-year-old female received postoperative radiation of the pelvis, and five years later MFH occurred in the sacral region. After a resection of this tumor, we performed cyclic systemic chemotherapy with cisplatin and adriamycin. The patient is currently doing well. Recently, MFH has been thought to be the most frequent soft tissue tumor in elderly patients, and also occurs frequently as a radiation-induced tumor. Since MFH tends to occur more than ten years after radiation, long-term follow up is important for early detection. We considered that surgical resection was an excellent treatment, while chemotherapy mainly composed of cisplatin was also thought to be effective. (author).

Morita, Kenji; Kawashima, Tadahisa; Park, K.R. (Kobe City General Hospital (Japan)) (and others)

1994-07-01

226

Primary malignant fibrous histiocytoma of the breast: report of one case.  

Science.gov (United States)

Seven years ago, a 48-year-old female patient discovered a painless tumor in her right breast simply by chance. In the next year, the tumor increased significantly in size. At this point, the patient received a tumor resection, which was misdiagnosed as a benign mesenchymal tissue-originated tumor. Unfortunately, the tumor recurred just 10 days after resection. We subsequently resected the recurrent lesion and confirmed primary breast malignant fibrous histiocytoma. The tumor began to exhibit an unprecedented, massive, and uncontrolled growth, ulcerating soon after the operation. Treatment of the patient was limited by time. After the patient received a cycle of chemotherapy, she died of cachexia with the emergence of multiorgan metastasis 2 months after the operation. PMID:23589696

Liu, Caigang; Zhao, Zuowei; Zhang, Qingfu; Wu, Yunfei; Jin, Feng

2013-04-03

227

Usefulness of bone scintigraphy on diagnosis of malignant fibrous histiocytoma of bone  

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We examined the roentgenographical features of 5 patients who were diagnosed histopathologically as malignant fibrous histiocytoma (MFH) of bone, especially on the imaging of bone scintigraphy. Two patients had multiple lesions on the initial examination, and two of 3 patients who showed solitary lesion on the first examination could be detected more pathological sites by bone scintigraphy which was studied within two months of the first investigation. On bone scintigraphy, the mixture of hot and cold lesions which was coincident with the osteolytic change on plain X-P could be noticed, and with the progression of osteolysis it had a tendency to increase the area of cold lesions. These features are similar to metastatic bone tumor which is the most questionable disease on diagnosis, and we conclude that bone scintigraphy will be absolutely necessary when MFH of bone is highly suspected in the clinical course.

Shimosegawa, Eku; Yamasaki, Tetuo; Shimizu, Masahiro; Nakamura, Mamoru; Sakamoto, Sumihiko

1989-02-01

228

Primary pulmonary malignant fibrous histiocytoma mimics pulmonary artery aneurysm with partial thrombosis: various radiologic evaluations  

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Primary pulmonary malignant fibrous histiocytoma (MFH) is very rare, so only a few imaging features have been reported. We report one case of rapidly growing primary pulmonary MFH mimicking a partially thrombosed pulmonary artery aneurysm and its radiologic findings, including multidetector row computed tomography (MDCT), conventional angiography, and fluorodeoxyglucose-positron emission tomography CT ([18F] FDG-PET/CT). On multi-phasic MDCT, this mass mimicked a pulmonary artery aneurysm with partial thrombosis. However, pulmonary artery aneurysm was excluded and suggested as a hypervascular parenchymal mass by subsequent conventional angiography. On [18F] FDG-PET/CT, it was a highly metabolic mass, showing a maximal standard uptake value (SUV) 12.1. Although primary pulmonary MFH is very rare and has no specific imaging findings, our experience might be helpful to differentiate a hypervascular pulmonary mass. (orig.)

Noh, Hyun Woo; Park, Kyung Joo; Sun, Joo Sung; Won, Je Hwan; Kwack, Kyu-Sung [Ajou University School of Medicine, Department of Radiology, Suwon (Korea); Choi, Ho [Ajou University School of Medicine, Department of Thoracic and Cardiovascular Surgery, Suwon (Korea); Lee, Kyi Beom [Ajou University School of Medicine, Department of Pathology, Suwon (Korea); Park, Joo Hun [Ajou University School of Medicine, Department of Pulmonary and Critical Care Medicine, Suwon (Korea)

2008-08-15

229

Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma.  

Science.gov (United States)

We analyzed the clinicopathological features of 9 breast malignant fibrous histiocytoma (MFH) patients. Immunohistochemistry was used to make both diagnosis and differential diagnosis, and to identify prognostic factors. All tumors lacked epithelial markers but expressed mesenchymal markers, suggesting a mesenchymal origin. Of the five cases expressing Ki-67, two of three patients with axillary lymph node involvement died between 6-8 months, and two died at 17 and 26 months after diagnosis. The two remaining cases, with low Ki-67 expression, had no recurrent or metastatic disease at 145 months after diagnosis. Previous studies have shown that surgery is the primary treatment of choice, but no clear benefit from adjuvant chemotherapy was observed. We demonstrate that axillary lymph node involvement and high expression of Ki-67 are associated with poorer prognosis. A literature review indicates surgery remains the first choice for MFH, but benefits from adjuvant chemotherapy remain unclear. PMID:23982330

Qiu, Si-Qi; Wei, Xiao-Long; Huang, Wen-He; Wu, Ming-Yao; Qin, Yun-Sheng; Li, Yang-Kang; Zhang, Guo-Jun

2013-08-28

230

Usefulness of bone scintigraphy on diagnosis of malignant fibrous histiocytoma of bone  

International Nuclear Information System (INIS)

We examined the roentgenographical features of 5 patients who were diagnosed histopathologically as malignant fibrous histiocytoma (MFH) of bone, especially on the imaging of bone scintigraphy. Two patients had multiple lesions on the initial examination, and two of 3 patients who showed solitary lesion on the first examination could be detected more pathological sites by bone scintigraphy which was studied within two months of the first investigation. On bone scintigraphy, the mixture of hot and cold lesions which was coincident with the osteolytic change on plain X-P could be noticed, and with the progression of osteolysis it had a tendency to increase the area of cold lesions. These features are similar to metastatic bone tumor which is the most questionable disease on diagnosis, and we conclude that bone scintigraphy will be absolutely necessary when MFH of bone is highly suspected in the clinical course. (author)

1989-01-01

231

A case of malignant fibrous histiocytoma following postoperative irradiation for carcinoma of the cervix  

International Nuclear Information System (INIS)

We report a case of malignant fibrous histiocytoma (MFH) following carcinoma of the cervix. A 28-year-old female received postoperative radiation of the pelvis, and five years later MFH occurred in the sacral region. After a resection of this tumor, we performed cyclic systemic chemotherapy with cisplatin and adriamycin. The patient is currently doing well. Recently, MFH has been thought to be the most frequent soft tissue tumor in elderly patients, and also occurs frequently as a radiation-induced tumor. Since MFH tends to occur more than ten years after radiation, long-term follow up is important for early detection. We considered that surgical resection was an excellent treatment, while chemotherapy mainly composed of cisplatin was also thought to be effective. (author)

1994-01-01

232

Primary malignant fibrous histiocytoma in mediastinum: Imaging with 18F FDG PET/CT  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma (MFH) is the most common soft tumor which often occurs in the extremities and the retroperitoneum. Pimary mediastinal MFH is rare; thus, findings on 18F fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG PET/CT) of mediastinal MFH have not been reported yet. We report herein the case of a 64 year old man who was presented with a superior mediastinal mass. the mass showed intense 18F FDG uptake with central metabolic defect on PET/CT the maximum standardized uptake value was 17.4. after tumor removal via median sternotomy, an MFH of the storiform pleomorphic type was diagnosed on histopathologic examination. We the first report of 18F FDG PET/CT imaging of MFH in the superior mediastinum

2012-01-01

233

Primary pulmonary malignant fibrous histiocytoma mimics pulmonary artery aneurysm with partial thrombosis: various radiologic evaluations  

International Nuclear Information System (INIS)

Primary pulmonary malignant fibrous histiocytoma (MFH) is very rare, so only a few imaging features have been reported. We report one case of rapidly growing primary pulmonary MFH mimicking a partially thrombosed pulmonary artery aneurysm and its radiologic findings, including multidetector row computed tomography (MDCT), conventional angiography, and fluorodeoxyglucose-positron emission tomography CT ([18F] FDG-PET/CT). On multi-phasic MDCT, this mass mimicked a pulmonary artery aneurysm with partial thrombosis. However, pulmonary artery aneurysm was excluded and suggested as a hypervascular parenchymal mass by subsequent conventional angiography. On [18F] FDG-PET/CT, it was a highly metabolic mass, showing a maximal standard uptake value (SUV) 12.1. Although primary pulmonary MFH is very rare and has no specific imaging findings, our experience might be helpful to differentiate a hypervascular pulmonary mass. (orig.)

2008-01-01

234

Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma.  

UK PubMed Central (United Kingdom)

We analyzed the clinicopathological features of 9 breast malignant fibrous histiocytoma (MFH) patients. Immunohistochemistry was used to make both diagnosis and differential diagnosis, and to identify prognostic factors. All tumors lacked epithelial markers but expressed mesenchymal markers, suggesting a mesenchymal origin. Of the five cases expressing Ki-67, two of three patients with axillary lymph node involvement died between 6-8 months, and two died at 17 and 26 months after diagnosis. The two remaining cases, with low Ki-67 expression, had no recurrent or metastatic disease at 145 months after diagnosis. Previous studies have shown that surgery is the primary treatment of choice, but no clear benefit from adjuvant chemotherapy was observed. We demonstrate that axillary lymph node involvement and high expression of Ki-67 are associated with poorer prognosis. A literature review indicates surgery remains the first choice for MFH, but benefits from adjuvant chemotherapy remain unclear.

Qiu SQ; Wei XL; Huang WH; Wu MY; Qin YS; Li YK; Zhang GJ

2013-08-01

235

Primary malignant fibrous histiocytoma of the breast: report of one case.  

UK PubMed Central (United Kingdom)

Seven years ago, a 48-year-old female patient discovered a painless tumor in her right breast simply by chance. In the next year, the tumor increased significantly in size. At this point, the patient received a tumor resection, which was misdiagnosed as a benign mesenchymal tissue-originated tumor. Unfortunately, the tumor recurred just 10 days after resection. We subsequently resected the recurrent lesion and confirmed primary breast malignant fibrous histiocytoma. The tumor began to exhibit an unprecedented, massive, and uncontrolled growth, ulcerating soon after the operation. Treatment of the patient was limited by time. After the patient received a cycle of chemotherapy, she died of cachexia with the emergence of multiorgan metastasis 2 months after the operation.

Liu C; Zhao Z; Zhang Q; Wu Y; Jin F

2013-01-01

236

Malignant fibrous histiocytoma of the breast. A case report and review of the literature  

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The clinicopathologic features of a malignant fibrous histiocytoma arising in a female breast are presented. Seven cases have been previously reported. These may be divided into three subgroups based on history and pathologic findings. Three of the seven occurred in women without a history of other tumors or previous irradiation. One appeared with a cystosarcoma phyllodes, and three arose following radiation for carcinoma of the breast. The patient in this study had received no radiation. Treatment has been based on surgical resection; the roles of chemotherapy and radiation are uncertain. Although resection alone in the first subgroup has lead to no reported mortality, the small number of cases and the relatively short follow-up does not allow a meaningful assessment of the prognosis in this disease.

Langham, M.R. Jr.; Mills, A.S.; DeMay, R.M.; O' Dowd, G.J.; Grathwohl, M.A.; Horsley, J.S.

1984-08-01

237

The basic chromospheres of skin that might not be differentiated visually: observations on aneurysmal fibrous histiocytomas and malignant melanomas.  

UK PubMed Central (United Kingdom)

AIM: Aneurysmal fibrous histiocytoma (AFH) is a variant of fibrous histiocytoma, which has a cleft-like cavernous blood-filled space in the tumor. It appears as a single reddish black tumor with variable levels of pain and size from its bleeding. And, it must be differentiated from other similar looking malignant conditions such as malignant melanoma. The visual mimicry of AFH to melanoma was raised by some careful dermatologists, but never be confirmed objectively by colorimetric analysis. MATERIALS, SUBJECTS, AND METHODS: In this study, we simply analyzed conventionally photographed digital images of thirty-seven cases of fibrous histiocytomas, including three AFH cases into colorimetrically useful color space, CIELAB, of which coordinates are L*, a*, and b* representing lightness, red to green, and yellow to blue axis, respectively. In addition, we also analyzed the clinical digital images of seven cases of malignant melanomas. Using statistical package, each coordinates of CIELAB were compared using Wilcoxon rank sum test between AFH and melanomas. The CIELAB coordinates of AFH and non-aneurysmal fibrous histiocytomas were compared statistically as well. RESULTS: Comparing with banal fibrous histiocytomas, the colors of AFH showed significantly smaller a* and b* coordinates (P = 0.008, 0.008, respectively), which implies more green and blue hue of AFH lesion. Rather, they were more like melanomas (P = 0.2839, 0.2040, respectively). As for L*, there were no significant differences for all comparisons. CONCLUSIONS: As a result, more objective analysis of the digital images using colorimetric color space confirmed the visual mimicry of AFH to melanoma.

Oh GN; Kim JY; Choi JE; Seo SH; Kye YC; Ahn HH

2013-02-01

238

MRI of angiomatoid fibrous histiocytoma  

International Nuclear Information System (INIS)

Angiomatoid fibrous histiocytoma is a rare soft tissue tumor of low-grade malignancy. We present the case of a 32-year-old man who complained of soreness and numbness over his left arm and hand over the previous 2 months and of having a palpable mass over his left upper back for 4 years. Magnetic resonance imaging (MRI) showed an intramuscular soft tissue mass in the left scapular region. The tumor mass was seen to have multiple cystic components with fluid-fluid levels. Histological examination showed multiple cystic spaces filled with blood lakes and hemosiderin deposits in the solid part of the tumor. After the initial surgery, the patient had local recurrences over 2.5 years. The immunohistochemical study at the second surgery showed that the recurrent tumor was strongly positive for the histiocytic marker CD68, and the myoid trait desmin. Histological diagnosis was compatible with angiomatoid fibrous histiocytoma. (orig.)

2004-01-01

239

MRI of angiomatoid fibrous histiocytoma  

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Angiomatoid fibrous histiocytoma is a rare soft tissue tumor of low-grade malignancy. We present the case of a 32-year-old man who complained of soreness and numbness over his left arm and hand over the previous 2 months and of having a palpable mass over his left upper back for 4 years. Magnetic resonance imaging (MRI) showed an intramuscular soft tissue mass in the left scapular region. The tumor mass was seen to have multiple cystic components with fluid-fluid levels. Histological examination showed multiple cystic spaces filled with blood lakes and hemosiderin deposits in the solid part of the tumor. After the initial surgery, the patient had local recurrences over 2.5 years. The immunohistochemical study at the second surgery showed that the recurrent tumor was strongly positive for the histiocytic marker CD68, and the myoid trait desmin. Histological diagnosis was compatible with angiomatoid fibrous histiocytoma. (orig.)

Li, Chao-Shiang; Chen, Wei-Tsung; Chen, Ran-Chou; Tu, Hsing-Yang [Taipei Municipal Jen-Ai Hospital, Department of Radiology, Taipei (Taiwan); Chan, Wing P. [Taipei Medical University, Department of Radiology, School of Medicine, Taipei (Taiwan); Taipei Municipal Wan-Fang Hospital, Department of Radiology, Taipei (Taiwan); Chang, Chih-Peng [Taipei Municipal Jen-Ai Hospital, Department of Orthopedic Surgery, Taipei (Taiwan); Shih, Li-Sun [Taipei Municipal Jen-Ai Hospital, Department of Pathology, Taipei (Taiwan)

2004-10-01

240

A case of irradiation-induced malignant fibrous histiocytoma after an operation for rectal cancer  

International Nuclear Information System (INIS)

We recently observed a case of presumed irradiation-induced malignant fibrous histiocytoma (MFH), which developed 11 years after postoperative chemoradiotherapy for residual rectal cancer. A 65-year-old female underwent chemoradiotherapy for the residual tumor on the sacrum after abdominoperineal resection for rectal cancer in 1991. She showed no evidence of local recurrence or distant metastasis. Biopsy and MRI in 2002 suggested a retroperitoneal malignant tumor associated with invasion of the uterus and the sacrum, and the patient subsequently underwent surgery. Histopathologically the tumor was MFH. This case was considered to be an irradiation-induced secondary malignant tumor, according to the criteria developed by Arlen et al. In elderly patients and cases that underwent chemoradiotherapy, the latency period of irradiation-induced secondary malignant tumor tends to be shorter. If the progress of postoperative adjuvant chemotherapy increases the number of long-term surviving cases in the future, the incidence of irradiation-induced secondary malignant tumor will increase. It is therefore necessary to survey these cases over a longer period of time after surgery. (author)

2004-01-01

 
 
 
 
241

Interleukin-6/Soluble Interleukin-6 Receptor Signaling Attenuates Proliferation and Invasion, and Induces Morphological Changes of a Newly Established Pleomorphic Malignant Fibrous Histiocytoma Cell Line  

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Pleomorphic malignant fibrous histiocytoma (MFH) is occasionally associated with inflammatory paraneoplastic syndrome (PNS). Recently, we reported that interleukin (IL)-6, one of the candidate cytokines, which induces such systemic inflammatory reaction, may be a tumor-associated factor involved in ...

Nakanishi, Hirofumi; Yoshioka, Kiyoko; Joyama, Susumu; Araki, Nobuhito; Myoui, Akira; Ishiguro, Shingo; Ueda, Takafumi

242

Diaphyseal medullary stenosis with malignant fibrous histiocytoma: a hereditary bone dysplasia/cancer syndrome maps to 9p21-22.  

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Diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMS-MFH) is an autosomal dominant bone dysplasia/cancer syndrome of unknown etiology. This rare hereditary cancer syndrome is characterized by bone infarctions, cortical growth abnormalities, pathological fractures, and eventual pain...

Martignetti, J A; Desnick, R J; Aliprandis, E; Norton, K I; Hardcastle, P; Nade, S; Gelb, B D

243

Locally aggressive orbital fibrous histiocytoma  

Directory of Open Access Journals (Sweden)

Full Text Available We report a rare presentation of a massive, locally aggressive, fibrous histiocytoma of the orbit. The importance of histopathological grading and appropriate management are highlighted.

Bajaj Mandeep; Sethi Anita; Kashyap Seema; Thanikachalam S; Pushker Neelam

2004-01-01

244

Malignant fibrous histiocytoma of the urinary bladder as a post-radiation secondary cancer: a case report  

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Full Text Available Abstract Introduction Malignant fibrous histiocytomas have been periodically reported as the primary tumor in various organs including the urinary bladder, and is the second most frequent sarcoma of the urinary tract in adults. This report discusses a case of the well established diagnosis of a malignant fibrous histiocytoma of the bladder occurring as a post-radiation cancer after the treatment of a cervical carcinoma. Our findings support those of many previous studies and make the view of the nature of the disease clearer. Case presentation We report the case of a 54-year-old Thai woman who had been treated with radiation therapy for cervical cancer, who presented to our facility with urinary incontinence. Initially, our patient was diagnosed as having a high-grade urothelial carcinoma. Subsequent radical surgery rendered the final pathological diagnosis, confirmed histologically and immunohistochemically as malignant fibrous histiocytoma, with clinical and pathological staging of T4b N0 M0. Adjuvant chemotherapy was provided for our patient. Conclusions This type of malignancy is very aggressive and easily misdiagnosed due to its rarity. Therefore, in a patient with a prior history of irradiation in the pelvic area, this should be considered as a differential diagnosis to ensure early correct diagnosis and treatment.

Nimmanon Thirayost; Ruengpoka Poonkiat

2011-01-01

245

Radiologic evaluation of malignant histiocytoma  

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Malignant fibrous histiocytoma is a new malignant tumor entity of histiocytic origin which arises as a primary tumor of the bone as well as the soft tissue. Radiologic features of 12 cases of pathologically proven intra-and extraosseous malignant fibrous histiocytoma were analyzed. The results were as follows : 1. Seven cases were of soft tissue origin and 5 cases were of primary bone origin. 2. Seven were male and 5 were female: Eight cases were beyond 5th decades. 3. The clinical presentations of malignant fibrous histiocytoma of the soft tissue origin were a mass with rapid growth or high rate of local recurrence. The roentgen evidence of soft tissue density mass was demonstrated in 7 cases and scintigraphic evidence of cortical invasion was suggested in 2 cases. 4. Malignant fibrous histiocytoma arising from bones had ill defined moth-eaten osteolytic lesion with cortical destruction, periosteal reaction and soft tissue extension. 5. Among 12 cases, there were 2 cases of pulmonary metastases and 2 cases of osseous metastases. 6. In the presence of soft tissue mass with locally aggressive behavior and/or nonspecific roentgen features of malignant bone tumor, one should consider the possibility of malignant fibrous histiocytoma.

Park, Ki Soon; Lee, Sun Wha; Yoon, Yup; Sung, Dong Wook; Ahn, Chi Yul [Kyung Hee University Hospital, Seoul (Korea, Republic of)

1987-06-15

246

Fibro-histiocitoma maligno de extremidade: relato de caso Malignant fibrous histiocytoma of the extremity: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Fibro-histiocitoma maligno é o sarcoma de tecidos moles mais encontrado em jovens. Raramente confina-se com exclusividade à pele e ao subcutâneo. O diagnóstico, na maioria das vezes, só é feito após excisão e estudo da peça cirúrgica. É agressivo, apresentando alto grau de recorrência local e metástases. Este artigo relata o caso de um paciente jovem com fibro-histiocitoma maligno de extremidade.Malignant fibrous histiocytoma is the most common soft tissue sarcoma found in young adults. It is rarely confined exclusively to the skin and subcutis. In most cases it is only diagnosed after excision and analysis of the tumor. It is aggressive, presenting a high degree of local recurrence and metastasis. This article reports a case of malignant fibrous histiocytoma on an extremity of a young adult patient.

Roberta Cardoso de Siqueira; Márcio Lobo Jardim; Valdir Bandeira; Rosana Maria de Cássia X. das Chagas Ferreira; Luciano Tavares Montenegro; Patrícia Guimarães; Virgínia Batista

2004-01-01

247

Central airway obstruction due to malignant fibrous histiocytoma metastasis in a case with Mounier-Kuhn syndrome.  

UK PubMed Central (United Kingdom)

Malign fibrous histiocytoma is one of the most observed soft tissue sarcomas seen in the adults. The most common metastasis region is the lung and metastasis. Mounier-Kuhn syndrome is characterized by the highly dilatation of the trachea and bronchi. We may encounter with the major airway obstruction in the endoluminal or extraluminal lung and mediastinal masses or those with both components together. In this article, we would like to highlight the occurrence of a rare seen clinical situation secondary to the giant mediastinal malign fibrous histiocytoma metastasis and the clinical difficulties experienced in resolving of the main airway obstruction caused by the mass. Since the lack of the similar studies conducted previously, we found the case worth presenting.

Dalar L; Eryüksel E; Ko?ar F; Karasulu AL; Urer N; Sökücü SN; Alt?n S

2012-01-01

248

A radiation-induced malignant fibrous histiocytoma of the soft tissue after a carcinoma of the cervix  

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Presented are two cases of a radiation-induced malignant fibrous histiocytoma of the soft tissue following a carcinoma of the cervix. Case 1 is that of a 51-year-old female, who received postoperative radiotherapy of the pelvis, consisting of 60 Gy/25 fractions for 5 weeks. A large gluteal mass occurred 15 years later. Although this tumor responded to the radiotherapy and hyperthermia, the patient died of a recurrence 27 months later. Case 2 is that of a 62-year-old female, who underwent postoperative radiotherapy of 40 Gy/16 fractions for 4 weeks. A left gluteal tumor appeared 18 years later. After a resection of this tumor, she had repeated local recurrences. Three years after the operation, radio-hyperthermia was administered, and the patient has been doing well for a year. The histological diagnosis for both cases was a malignant fibrous histiocytoma of the ordinal type, which was considered to be a radiation-induced sarcoma. (author).

Nishimura, Tetsuo; Nozue, Masashi; Teshima, Takeshi; Suenaga, Ichiro; Furuhashi, Kyo; Kaneko, Masao; Okada, Masahito; Miura, Katsutoshi (Hamamatsu Univ., Shizuoka (Japan). School of Medicine)

1991-08-01

249

Fibro-histiocitoma maligno de extremidade: relato de caso/ Malignant fibrous histiocytoma of the extremity: a case report  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Fibro-histiocitoma maligno é o sarcoma de tecidos moles mais encontrado em jovens. Raramente confina-se com exclusividade à pele e ao subcutâneo. O diagnóstico, na maioria das vezes, só é feito após excisão e estudo da peça cirúrgica. É agressivo, apresentando alto grau de recorrência local e metástases. Este artigo relata o caso de um paciente jovem com fibro-histiocitoma maligno de extremidade. Abstract in english Malignant fibrous histiocytoma is the most common soft tissue sarcoma found in young adults. It is rarely confined exclusively to the skin and subcutis. In most cases it is only diagnosed after excision and analysis of the tumor. It is aggressive, presenting a high degree of local recurrence and metastasis. This article reports a case of malignant fibrous histiocytoma on an extremity of a young adult patient.

Siqueira, Roberta Cardoso de; Jardim, Márcio Lobo; Bandeira, Valdir; Ferreira, Rosana Maria de Cássia X. das Chagas; Montenegro, Luciano Tavares; Guimarães, Patrícia; Batista, Virgínia

2004-10-01

250

A radiation-induced malignant fibrous histiocytoma of the soft tissue after a carcinoma of the cervix  

International Nuclear Information System (INIS)

Presented are two cases of a radiation-induced malignant fibrous histiocytoma of the soft tissue following a carcinoma of the cervix. Case 1 is that of a 51-year-old female, who received postoperative radiotherapy of the pelvis, consisting of 60 Gy/25 fractions for 5 weeks. A large gluteal mass occurred 15 years later. Although this tumor responded to the radiotherapy and hyperthermia, the patient died of a recurrence 27 months later. Case 2 is that of a 62-year-old female, who underwent postoperative radiotherapy of 40 Gy/16 fractions for 4 weeks. A left gluteal tumor appeared 18 years later. After a resection of this tumor, she had repeated local recurrences. Three years after the operation, radio-hyperthermia was administered, and the patient has been doing well for a year. The histological diagnosis for both cases was a malignant fibrous histiocytoma of the ordinal type, which was considered to be a radiation-induced sarcoma. (author)

1991-01-01

251

Radiation-induced malignant fibrous histiocytoma: a report of five cases including two occurring post whole brain irradiation  

International Nuclear Information System (INIS)

Five patients who were successfully treated with external radiation therapy for a variety of histologically unrelated tumors subsequently developed malignant fibrous histiocytoma (MFH) within the irradiated field. It is suggested that therapeutic irradiation was a causative factor in the development of these tumors with latent periods ranging between 3 and 17 years. A review of the pertinent literature is presented. It is apparent that postradiation MFH is being recognized with increasing frequency and at an earlier age than when it appears de novo

1985-01-01

252

Radiation-induced malignant fibrous histiocytoma: a report of five cases including two occurring post whole brain irradiation  

Energy Technology Data Exchange (ETDEWEB)

Five patients who were successfully treated with external radiation therapy for a variety of histologically unrelated tumors subsequently developed malignant fibrous histiocytoma (MFH) within the irradiated field. It is suggested that therapeutic irradiation was a causative factor in the development of these tumors with latent periods ranging between 3 and 17 years. A review of the pertinent literature is presented. It is apparent that postradiation MFH is being recognized with increasing frequency and at an earlier age than when it appears de novo.

Amendola, B.E.; Amendola, M.A.; McClatchey, K.D.

1985-01-01

253

Malignant Fibrous Histiocytoma of the Maxilla-Report of A case  

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Malignant fibrous histiocytoma(MFH) of the maxilla is a rare malignant bone tumor. Seven percents of all MFH occur in the head and neck. Approximately 12% of these tumors occur in the maxilla. Local recurrence or distant metastasis was reported in 55% of cases of maxillary MFH. The mean survival time of 30 months was reported from a review of 14 MFHs in the masxilla, mandible and oral soft tissues. MFH of the maxilla is best treated surgically but radical neck dissection dose not appear to be indicated unless there is clinical evidence of lymph node metastases. Although the use of radiation therapy for head and neck MFH has not been studied for a series of cases, individual cases of regression or histological change have been reported. Other authors have reported numbers of cases who received radiation therapy without benefit. Response to combination chemotherapy has been reported in 33% of 23 patients with recurrent or metastatic MFH. We report here a case of MFH occurring in the maxilla with a review of literature about the clinical behavior and treatment of these lesions.

Oh, Yoon Kyeong; Yeo, Hwan Ho [Chosun Univ. College of Medicine, Kwangju (Korea, Republic of)

1995-09-15

254

Malignant Fibrous Histiocytoma of the Maxilla-Report of A case  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma(MFH) of the maxilla is a rare malignant bone tumor. Seven percents of all MFH occur in the head and neck. Approximately 12% of these tumors occur in the maxilla. Local recurrence or distant metastasis was reported in 55% of cases of maxillary MFH. The mean survival time of 30 months was reported from a review of 14 MFHs in the masxilla, mandible and oral soft tissues. MFH of the maxilla is best treated surgically but radical neck dissection dose not appear to be indicated unless there is clinical evidence of lymph node metastases. Although the use of radiation therapy for head and neck MFH has not been studied for a series of cases, individual cases of regression or histological change have been reported. Other authors have reported numbers of cases who received radiation therapy without benefit. Response to combination chemotherapy has been reported in 33% of 23 patients with recurrent or metastatic MFH. We report here a case of MFH occurring in the maxilla with a review of literature about the clinical behavior and treatment of these lesions

1995-01-01

255

Simultaneous occurrence of malignant fibrous histiocytoma and hepatocellular carcinoma in cirrhotic liver: A case report  

Directory of Open Access Journals (Sweden)

Full Text Available Primary hepatic malignant fibrous histiocytoma (MFH) is rarely encountered. There have been no reports to date of hepatic MFH associated with liver cirrhosis. The presence of liver cirrhosis is considered an adjunctive feature favoring sarcomatoid hepatocellular carcinoma (HCC) in the diagnosis of spindle cell tumors in liver. We describe here a 59-year-old man with liver cirrhosis due to hepatitis B virus infection 20 years ago. On abdominal computed tomography scanning, two distinct hepatic masses were identified in the background of cirrhosis, which had different radiological features from conventional HCC. He underwent segmentectomy for removal of the tumors. The pathological examination of surgically resected specimen revealed the large malignant spindle cell tumor and small conventional HCC. Additional tissue sampling and immunohistochemical stainings demonstrated that the spindle cell tumor was consistent with MFH. On the post-operative follow-up for 21 mo, a round mass showing similar radiological findings for the previous MFH was appeared on the surface of resection margin, suggesting the recurrence. Despite its rarity, hepatic MFH should be considered during differential diagnosis, even in cirrhotic patients, and extensive tissue sampling and immunohistochemical analyses are necessary in the diagnosis of hepatic spindle cell tumors.

Hee Sang Hwang; Nam Du Ha; Yoong Ki Jeong; Jae Hee Suh; Hye Jeong Choi; Young Min Kim; Hee Jeong Cha

2011-01-01

256

Pure sarcomatoid carcinoma of maxillary sinus and nasal cavity simulating malignant fibrous histiocytoma.  

UK PubMed Central (United Kingdom)

Although a few cases of sinonasal carcinoma with focal sarcomatous differentiation have been reported, pure sarcomatoid carcinoma has not been reported in the English literature. Imaging studies and gross inspection in a 60-year-old man with left-sided face pain revealed a mass in the left maxillary sinus and nasal cavity. A large incisional biopsy specimen from the nasal cavity revealed proliferation of malignant spindle and round cells with a malignant fibrous histiocytoma (MFH) pattern. Tumor giant cells were scattered, and there were areas of a vague storiform pattern. Mitotic figures were numerous. Carcinomatous component was not recognized. The histologic diagnosis was storiform-pleomorphic MFH. Tumor cells were positive for pancytokeratins AE1/3, KL-1, and CAM5.2 and cytokeratin (CK) 18, vimentin, CD68, p53, Ki-67 (labeling, 90%), ??-antitrypsin, and ??-antichymotrypsin and negative for pancytokeratin WSS, CK 34?E14, CK7, CK8, CK14, CK19, CK20, epithelial membrane antigen, S-100 protein, desmin, ?-smooth muscle actin, CD34, HMB45, chromogranin, synaptophysin, myoglobin, CD45, CD30, and CD15. Because keratins were positive in tumor cells, a diagnosis of sarcomatoid carcinoma simulating MFH was made. The patient was treated with chemoradiation without significant effect and died 9 months after initial examination.

Terada T

2011-01-01

257

[Undifferentiated high grade pleomorphic sarcoma/ malignant fibrous histiocytoma associated a gouty tophus. a case report].  

UK PubMed Central (United Kingdom)

BACKGROUND: Gout is a metabolic disease by deposition of uric acid crystals, which undertakes joint and soft tissue in both acute and chronic stages. Is a rare event the onset of a tumor in the site of the lesion. OBJECTIVE: To present a rare case of association between sarcoma and tophi. METHODS: 83 year old man who consulted for tumor in his left elbow about 40 years of evolution, which spontaneously started to hurt. With the presumptive diagnosis of tophi treated surgically. The lesion recurred after 60 days, reintervention and radiotherapy was performed for diagnosis of malignant mesenchymal tumor associated with tophi. At 10 months developed ipsilateral nodal metastases, died within 2 years of the initial consultation. RESULTS: The diagnosis of the first material resected was tophi. In the reintervention material was diagnosed mesenchymal spindle cell high grade neoplasm associated with tophi; immunohistochemistry revealed: vimentin + / +, MYO D1 - / - ASMA - / -, FVIII - / -, A1ATT - / -, CD68-/ -, S100-/ - with final diagnosis the undifferentiated high grade pleomorphic sarcoma. CONCLUSIONS: It is uncommon for gouty tophi are associated with other diseases and even fewer do so to tumors. In the literature have reported three previous cases concurrent with neoplasms, which were angiosarcoma, giant cell tumor and malignant fibrous histiocytoma. The latter have a high tendency to recur locally and have ability to distant metastases, especially lung and regional lymph nodes.

Szlabi S; Flores JO; de Diller AL; Cabrera M

2012-01-01

258

Histiocitoma fibroso maligno retroperitoneal: A propósito de un caso/ Retroperitoneal malignant fibrous histiocytoma: case report  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Objetivo: Presentar un caso de una tumoración retroperitoneal de gran tamaño con diagnóstico patológico de Histiocitoma fibroso maligno y revisar aspectos diagnósticos y terapéuticos de la literatura actual. Método: Presentamos el caso de un hombre de 75 años de edad que durante un ingreso en el servicio de digestivo por clínica de astenia de meses de evolución y problemas gastrointestinales se realiza CT abdomino-pélvico, identificando gran masa de 20 x 22 x 1 (more) 2 cm que parece depender del riñón izquierdo junto a aneurisma de aorta abdominal de 8 cm de diámetro. Resultados: Se somete al paciente a intervención quirúrgica donde se realiza Nefrectomía radical izquierda más resección radical de masa retroperitoneal, que histológicamente corresponde a un Histiocitoma fibroso maligno, tipo estoriforme-pleomórfico con focos de degeneración hialina (Estadio pT2b). Conclusiones: Los sarcomas son neoplasias infrecuentes. Pueden adoptar una gran variedad de patrones morfológicos y distintos grados de diferenciación. El tratamiento quirúrgico continúa siendo la única terapia con posibilidades curativas. El tratamiento adyuvante radioterápico y/o quimioterápico es cuestionado. Abstract in english Objective: We present the case of a big retroperitoneal tumor that received the pathologic diagnosis of malignant fibrous histiocytoma. We also review the diagnostic and therapeutic features of this disease in the current literature. Methods: We present the case of a 75-year-old male who was admitted to the Gastrointestinal Disease Department with asthenia of several months of evolution and gastrointestinal problems. Abdominopelvic CT scan revealed a big mass of 20 x 22 x (more) 12 cm, which seems to depend from the left kidney, together with an 8 cm diameter abdominal aortic aneurysm. Results: The patient underwent surgery and left radical nephrectomy together with radical resection of the retroperitoneal mass were performed. Pathology reportes malignant fibrous histiocytoma of the storiform-pleomorphic type, with hyaline degeneration foci (stadium pT2B). Conclusions: Sarcomas are rare neoplasias. They can adopt several different morphologic patterns, as well as many differentiation degrees. The surgical treatment is still the only therapy with healing possibilities. Adjuvant treatments through radiotherapy and/or chemotherapy are brought into question.

Eguíluz Lumbreras, Pablo; Palacios Hernández, Alberto; Heredero Zorzo, Oscar; García García, Javier; Cañada de Arriba, Florencio; Pérez Herrero, Federico; Gómez Zancajo, Ramón

2010-08-01

259

Brain metastases of a malignant fibrous histiocytoma presenting as an acute cerebral hemorrhage.  

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Intracranial metastases from malignant fibrous histiocytoma (MFH) are rare, particularly with associated hemorrhage. This article reports one case and presents a review of the literature on this topic. A 55-year-old man presented with acute drowsiness, aphasia and right homonymous hemianopsia and hemiparesis. The first CT scan showed a left occipitoparietal hematoma and the second one, nodular, contrast-enhanced lesions. He had been previously operated on soft tissues MFH. Lung metastases developed subsequently. A craniotomy was performed with evacuation of the hematoma and total gross resection of the mass lesions. Microscopic examination disclosed a metastasis from a MFH. Neoangiogenesis, stimulated by angiogenic growth factors, seems to take part in this vascular, stroke-like event. Due to longer survivals of patients harboring systemic sarcomas, these tumors should be considered in the differential diagnosis of intracranial neoplasms, whether hemorrhagic or not. In particular, history of a previous soft tissue or heart tumor associated with lung metastasis should evoke the possibility of MFH metastasis. PMID:11327299

Pimentel, J; Fernandes, A C; Silva, R; Ferro, J; Cattoni, B

260

Brain metastases of a malignant fibrous histiocytoma presenting as an acute cerebral hemorrhage.  

UK PubMed Central (United Kingdom)

Intracranial metastases from malignant fibrous histiocytoma (MFH) are rare, particularly with associated hemorrhage. This article reports one case and presents a review of the literature on this topic. A 55-year-old man presented with acute drowsiness, aphasia and right homonymous hemianopsia and hemiparesis. The first CT scan showed a left occipitoparietal hematoma and the second one, nodular, contrast-enhanced lesions. He had been previously operated on soft tissues MFH. Lung metastases developed subsequently. A craniotomy was performed with evacuation of the hematoma and total gross resection of the mass lesions. Microscopic examination disclosed a metastasis from a MFH. Neoangiogenesis, stimulated by angiogenic growth factors, seems to take part in this vascular, stroke-like event. Due to longer survivals of patients harboring systemic sarcomas, these tumors should be considered in the differential diagnosis of intracranial neoplasms, whether hemorrhagic or not. In particular, history of a previous soft tissue or heart tumor associated with lung metastasis should evoke the possibility of MFH metastasis.

Pimentel J; Fernandes AC; Silva R; Ferro J; Cattoni B

2001-03-01

 
 
 
 
261

18F-FDG PET imaging of malignant fibrous histiocytoma in hip  

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Objective: A 56-year-old woman presented with 5-year history of pain and swelling of right hip. Four operations had been performed on the patients. The pathological diagnosis was low-grade malignant fibrous histiocytoma (MFH) of soft tissue. In fasting state, the patient received 155 MBq (4.2 mCi) of 18F-FDG intravenously. A whole-body PET study was performed with image acquisition starting at 50 min after 18F-FDG injection. Emission and 137Cs-source transmission study were obtained. The attenuation corrected whole-body images were reconstructed by iteration. 18F-FDG PET images showed merging focuses of radiotracer accumulation in the right hip's soft tissue mass as well as the right iliac bone and the upper end of right femur. The maximal standard uptake value (SUVmax) was 7.3. Histological grading of soft tissue tumors is challenging because large heterogeneous tumor masses may cause sampling errors with underestimation of aggressiveness. The studies demonstrated increased uptakes of 18F-FDG in the patients with intermediate- and high-grade MFH. 18F-FDG PET imaging may be used to differentiate more aggressive MFHs from less aggressive ones and detect local recurrence and distant metastases

2002-01-01

262

Clinical report on transarterial neoadjuvant chemotherapy of malignant fibrous histiocytoma in soft tissue.  

UK PubMed Central (United Kingdom)

PURPOSE: To review the experience in transarterial neoadjuvant chemotherapy of malignant fibrous histiocytoma (MFH) in soft tissue and to analyze the factors related to prognosis of MFH in soft tissue. METHODS: Between September 1999 and December 2011, 101 cases of MFH in soft tissue patients treated by transarterial administration of Cisplatin, Adriamycin and Norcantharidin were divided into primary group and recurrent group, and the clinical documents were reviewed. Nine factors that might affect prognosis such as age, sex, tumor size, tumor site, tumor infiltration depth, recurrence if any, pathological type, histologic grade and histologic response of chemotherapy were analyzed statistically. RESULTS: The 5-year relapse-free survival rate and the overall survival rate were 70.5 and 75.0 %, respectively, in the primary group; 56.1 and 57.9 %, respectively, in the recurrent group. Univariate analysis (log-rank test) showed that the factors affecting the prognosis were age (P = 0.03), tumor size (P = 0.01), pelvic tumor (P = 0.02), recurrence if any (P = 0.004), histologic grade (P = 0.01), and histologic response to chemotherapy (P = 0.007). Multivariate analysis showed that the major factors affecting prognosis were pelvic tumor (P = 0.01), tumor size (P = 0.002), histologic grade (P = 0.002), recurrence if any (P = 0.0004), and histologic response to chemotherapy (P = 0.008). CONCLUSION: Transarterial neoadjuvant chemotherapy can significantly increase the curative efficacy of chemotherapy and survival rate in MFH treatment.

Guo J; Cui Q; Liu C; Sui J; Jiang N; Zhou J; Li D; Zeng Y

2013-05-01

263

Malignant fibrous histiocytoma of the oral and maxillofacial region: a report of three cases  

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Malignant fibrous histiocytoma (MFH) is a pleomorphic soft tissue sarcoma. Three cases of MFH were reported in our study. The first case involved in the right infratemporal fossa of a 32-year-old female was presented. MR imaging revealed a 5.0 x 3.3 cm soft tissue mass of inhomogeneous high signal intensity. The second caes was found in the right hard palate of a 66-year-old male. CT demonstrated bone destruction and MR imaging showed a 4 x 4 cm sized soft tissue mass of heterogeneous high signal intensity. The final case was found in the left masticator space of a 37-year-old male. The CT image showed a large mass with massive bone destruction of the left mandibular ramus, while the MRI displayed a soft tissue mass, 8 cm diameter. Our cases exhibited the general features of MFH. MRI is essential in the imaging of MFH, namely to depict tumor borders and demonstrate relationships with adjacent structures.

Han, Dong Hun; Heo, Min Suk; Lee, Sam Sun; Lee, Jin Koo; Choi, Soon Chul [Seoul National University College of Medicine, Seoul (Korea, Republic of); Choi, Jeong Hee [Chonnam National University College of Medicine, Kwangju (Korea, Republic of)

2003-12-15

264

Malignant fibrous histiocytoma of the oral and maxillofacial region: a report of three cases  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma (MFH) is a pleomorphic soft tissue sarcoma. Three cases of MFH were reported in our study. The first case involved in the right infratemporal fossa of a 32-year-old female was presented. MR imaging revealed a 5.0 x 3.3 cm soft tissue mass of inhomogeneous high signal intensity. The second caes was found in the right hard palate of a 66-year-old male. CT demonstrated bone destruction and MR imaging showed a 4 x 4 cm sized soft tissue mass of heterogeneous high signal intensity. The final case was found in the left masticator space of a 37-year-old male. The CT image showed a large mass with massive bone destruction of the left mandibular ramus, while the MRI displayed a soft tissue mass, 8 cm diameter. Our cases exhibited the general features of MFH. MRI is essential in the imaging of MFH, namely to depict tumor borders and demonstrate relationships with adjacent structures.

2003-01-01

265

Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report  

International Nuclear Information System (INIS)

A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

2013-01-01

266

Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features  

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Full Text Available Abstract Background The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a series of 57 so-called MFH of bone within the framework of the EuroBoNeT consortium according to up-to-date criteria and ancillary immunohistochemistry, a fourth of all tumors were reclassified and subtyped. Methods In the present study, the cytogenetic data on 11 of these tumors (three myoepithelioma-like sarcomas, two leiomyosarcomas, one undifferentiated pleomorphic sarcoma with incomplete myogenic differentiation, two undifferentiated pleomorphic sarcomas, one osteosarcoma, one spindle cell sarcoma, and one unclassifiable biphasic sarcoma) are presented. Results All tumors were high-grade lesions and showed very complex karyotypes. Neither the overall pattern (ploidy level, degree of complexity) nor specific cytogenetic features distinguished any of the subtypes. The subgroup of myoepithelioma-like sarcomas was further investigated with regard to the status of the EWSR1 and FUS loci; however, no rearrangement was found. Nor was any particular aberration that could differentiate any of the subtypes from osteosarcomas detected. Conclusions chromosome banding analysis is unlikely to reveal potential genotype-phenotype correlations between morphologic subtypes among so-called MFH of bone.

Mertens Fredrik; Romeo Salvatore; Bovée Judith VMG; Tirabosco Roberto; Athanasou Nick; Alberghini Marco; Hogendoorn Pancras CW; Dei Tos Angelo P; Sciot Raf; Domanski Henryk A; Åström Kristina; Mandahl Nils; Debiec-Rychter Maria

2011-01-01

267

Malignant fibrous histiocytoma of bone: conventional X-ray and MR imaging features  

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Objective. To evaluate the conventional X-ray and MR imaging features of malignant fibrous histiocytoma (MFH) of bone. Design. MRI examinations and conventional radiographs were reviewed in 39 patients with biopsy-proven MFH. Imaging characteristics were analyzed and the differential diagnoses assessed in a masked fashion by two experienced radiologists. Results. Typical X-ray features included aggressive, destructive tumor growth centrally located in the metaphysis of long bones. Periosteal reactions and expansive growth were rarely seen. On MR images extraosseous tumor spread was frequently noted. On T2-weighted images and contrast-enhanced T1-weighted images most of the tumors displayed an inhomogeneous, nodular signal pattern with peripheral Gd-DTPA enhancement. Conclusions. Although several MR imaging criteria were typical for MFH none of them was specific. X-ray diagnosis of MFH may also prove difficult, with the main differential diagnosis being metastasis in the older and osteosarcoma in the younger population. (orig.) With 7 figs., 1 tab., 26 refs.

Link, T.M.; Haeussler, M.D.; Poppek, S.; Woertler, K.; Rummeny, E.J. [Institute of Clinical Radiology, University Hospital, Muenster (Germany); Blasius, S. [Department of Pathology, University Hospital, Muenster (Germany); Lindner, N. [Department of Orthopedics, University Hospital, Muenster (Germany)

1998-10-01

268

Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report  

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A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

Park, Hye Young; Seo, Jung Wook; Lee, Byung Hoon; Lee, Ji Young; Kim, Su Young; Cha, Soon Joo; Kim, Yong Hoon; Hwang, Yoon Joon; Kim, You Sung [Dept. of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang (Korea, Republic of)

2013-03-15

269

Abdominal malignant fibrous histiocytoma infiltrating stomach with Chilaiditi's sign manifestation (a rare case report).  

Science.gov (United States)

The incidence and mortality rate of gastric cancer are decreasing within last 60 years. Approximately 85% of gastric cancer is carcinoma where as the rest 15% is lymphoma and sarcoma. Leiomyosarcoma is the most frequently encountered sarcoma in stomach and represents 1-3% gastric cancer. This tumor is frequently located in the anterior and posterior wall of gastric fundus accompanied by ulceration and bleeding. Malignant fibrous histiocytoma (MFH) is a soft tissue tumor with poor prognosis, rarely found in stomach. This tumor is most frequently originated from inner fascia or skeletal muscle (58-75%) and most frequently happen in the peritoneal cavity and abdomen (9-16 %). We reported a 45-year-old woman with abdominal MFH which infiltrated to the lesser curvature of stomach with Chilaiditi sign. Chilaiditi sign is a condition of intestine disposition (usually at the hepatic flexure of colon) which lies between liver and diagfragma, found in 0.1 ? 0.25% cases which is diagnosed by chest X Ray. This case is a very rare case. PMID:17684443

Nurdjanah, Siti; Bayupurnama, Putut; Maduseno, Sutanto; Ratnasari, Neneng

2007-01-01

270

Abdominal malignant fibrous histiocytoma infiltrating stomach with Chilaiditi's sign manifestation (a rare case report).  

UK PubMed Central (United Kingdom)

The incidence and mortality rate of gastric cancer are decreasing within last 60 years. Approximately 85% of gastric cancer is carcinoma where as the rest 15% is lymphoma and sarcoma. Leiomyosarcoma is the most frequently encountered sarcoma in stomach and represents 1-3% gastric cancer. This tumor is frequently located in the anterior and posterior wall of gastric fundus accompanied by ulceration and bleeding. Malignant fibrous histiocytoma (MFH) is a soft tissue tumor with poor prognosis, rarely found in stomach. This tumor is most frequently originated from inner fascia or skeletal muscle (58-75%) and most frequently happen in the peritoneal cavity and abdomen (9-16 %). We reported a 45-year-old woman with abdominal MFH which infiltrated to the lesser curvature of stomach with Chilaiditi sign. Chilaiditi sign is a condition of intestine disposition (usually at the hepatic flexure of colon) which lies between liver and diagfragma, found in 0.1 ? 0.25% cases which is diagnosed by chest X Ray. This case is a very rare case.

Nurdjanah S; Bayupurnama P; Maduseno S; Ratnasari N

2007-01-01

271

[Prognostic significance of the clinical x-ray and morphological signs in malignant fibrous histiocytoma of bone  

UK PubMed Central (United Kingdom)

Forty-four cases of malignant fibrous histiocytoma were studied. A new index for patients' survival prognosis was developed and defined as a tumor growth rate. It is a ratio of maximal tumor size and duration of disease. Eight clinical x-ray and morphological factors of prognosis were identified: duration of disease, clinical manifestations, size and roentgenologic type of tumor, pattern of tumor contours, status of the cortical layer in bone lesions, tumor growth rate and morphologic grade of malignancy. A multifactorial analysis was carried out and data were presented in tables. Values of each parameter were calculated.

Petrovichev NN; Khmelev ON; Annamukhamedov A; Dvorova EK

1987-01-01

272

[Prognostic significance of the clinical x-ray and morphological signs in malignant fibrous histiocytoma of bone].  

Science.gov (United States)

Forty-four cases of malignant fibrous histiocytoma were studied. A new index for patients' survival prognosis was developed and defined as a tumor growth rate. It is a ratio of maximal tumor size and duration of disease. Eight clinical x-ray and morphological factors of prognosis were identified: duration of disease, clinical manifestations, size and roentgenologic type of tumor, pattern of tumor contours, status of the cortical layer in bone lesions, tumor growth rate and morphologic grade of malignancy. A multifactorial analysis was carried out and data were presented in tables. Values of each parameter were calculated. PMID:2827391

Petrovichev, N N; Khmelev, O N; Annamukhamedov, A; Dvorova, E K

1987-01-01

273

Subcutaneous angiomatoid fibrous histiocytoma mimicking metastatic melanoma.  

UK PubMed Central (United Kingdom)

Angiomatoid fibrous histiocytoma is an uncommon soft-tissue tumor of intermediate malignancy that is often misdiagnosed initially. As there is not one immunohistochemical marker that consequently stains positive or negative for angiomatoid fibrous histiocytoma, molecular diagnostics are becoming more widely used. So far three translocations have been reported to arise in angiomatoid fibrous histiocytoma: FUS-ATF1, EWSR1-CREB1, or EWSR1-ATF1. We present a case of angiomatoid fibrous histiocytoma on the upper arm of a 40-year-old female, which was initially misdiagnosed as metastatic melanoma in a lymph node. Revision of the pathology revealed an angiomatoid fibrous histiocytoma, which was later confirmed by a EWSR1-CREB1 translocation with molecular diagnostics. Furthermore, we review the relevant literature and provide an overview of all available case reports in the past ten years. This case report illustrates the importance for pathologists of knowing the typical pathology features of AFH and integrating immunohistochemical and molecular findings in order to prevent overdiagnosis of lymph node metastasis of a malignancy.

Sparreboom E; Wetzels C; Verdijk M; Mulder S; Blokx W

2012-01-01

274

A therapeutic strategy for metastatic malignant fibrous histiocytoma through mesenchymal stromal cell-mediated TRAIL production.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To overcome the therapeutic limitations of malignant fibrous histiocytoma (MFH), we evaluated human adipose tissue-derived mesenchymal stromal cells (MSCs) that secrete tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on metastatic MFH. BACKGROUND: MFH is a highly malignant and metastatic type of sarcoma but surgical removal is the only effective method for treating MFH. MSCs are easily transduced to express a high level of transgene and can migrate toward cancer. For this reason, MSCs are a promising candidate for metastatic MFH therapies. METHODS: In vitro sustainability of MSC-TRAIL against MFH-ino was analyzed by apoptosis assay. For preclinical study, anti-MFH effects of MSC-TRAILs were validated in murine models for local tumorigenesis and metastasis. Furthermore, a time-interval metastasis model of MFH was applied to confirm antimetastatic ability of MSC-TRAIL for preestablished metastatic MFH. RESULTS: We found that MFH-ino is highly susceptible to recombinant TRAIL and MSC-TRAIL, which selectively induce apoptosis via caspase-8 activation in vitro. Moreover, not only MFH-ino but xenograft explants were also significantly inhibited by MSC-TRAIL in local tumorigenesis. In particular, the metastatic ability of MFH-ino was considerably reduced by MSC-TRAIL in metastasis murine model, particularly for preestablished metastatic MFH. CONCLUSIONS: These results suggest that MSC-TRAIL is sufficiently effective in inhibiting MFH-ino metastasis and the application using MSC-TRAIL could be extended to other sarcomas and recurrent metastatic cancers for cell-mediated cancer therapy.

Lee HJ; Yang HM; Choi YS; Park SH; Moon SH; Lee YS; Sung YC; Kim SJ

2013-05-01

275

Thermoradiotherapy in the treatment of soft-tissue malignant fibrous histiocytoma of the extremities  

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From 1982 through 1989, five patients with soft-tissue malignant fibrous histiocytoma (MFH) of the extremities were treated with thermoradiotherapy in Kyoto University Hospital. All patients were male, and their ages ranged from 66 to 84 years. All of the tumors were locally recurrent ones following initial treatments. The initial treatments included wide excision followed by chemotherapy in one tumor, local excision with postoperative radiotherapy (60 Gy/2 Gy) in one tumor, and one to three times of local excision in the remaining three tumors. Hyperthermia was administered by an 8 MHz RF capacitive heating device or a 430 MHz microwave hyperthermia system for a total of 3 to 12 sessions (mean: 7 sessions). The total radiation dose ranged from 25 Gy to 70 Gy. regarding the tumor response, two tumors showed complete regression (CR), two showed no response (NR; less than 50% regression), and one tumor was resected 4 months after the treatment, in which no malignant tumor cells were detected by histological examination. Thus, good tumor response was obtained in three tumors. In addition, none of these tumors have shown recurrence in the follow up period of 4 to 36 months (mean: 15 months). CT scans performed after thermoradiotherapy demonstrated remarkable intratumor low density area in effectively heated tumors, and this CT change was useful to evaluate the initial effects of thermoradiotherapy. No serious complications associated with the combined treatment were noted in this study. These results suggest that hyperthermia is a useful adjuvant to radiotherapy in the treatment of soft-tissue MFH of the extremities. (author)

1991-01-01

276

Primary Malignant Fibrous Histiocytoma of the Lung: A Report of 20 Cases  

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Full Text Available Background and objective Primary malignant fibrous histiocytoma (MFH) of the lung is a type of rare sarcoma which showed a lack of detailed guidance about treatment and prognosis. The clinical features, treatment methods and prognosis of primary MFH of the lung were analyzed by this study to reveal some information of this disease. Methods The clinical data and survival state of 20 patients with primary pulmonary MFH treated in Cancer Institute and Hospital of Tianjin Medical University were collected. SPSS 16.0 software was used for statistical analysis. Kaplan-Meier method was applied to figure out whether gender, size, site and post-operative chemotherapy correlated to prognosis. COX regression was employed for multivariate prognostic analysis to find the unattached prognostic factors. Statistical significance was considered at P<0.05. Results The clinical manifestations of primary pulmonary MFH mainly included cough, blood-stained sputum, chest pain, fever and chest distress. The one-year and two-year overall survival rates were 55.0% and 25.0%, respectively. Most cases died of local recurrence and distant metastasis. Multivariate COX regression analysis showed tumor size and location type were unattached prognostic factors. The patients with tumors smaller than 5 cm had a median survival of 27 months, while larger than 5 cm group’s median survival was 8 months. The median survival of central tumor and the peripheral tumor were 6 months and 23 months respectively. Conclusion Primary pulmonary MFH was a type of highly malignant sarcoma which had poor prognosis. The main effective treatment was surgery, yet the role of postoperative adjuvant chemotherapy in the whole course of treatment was undefined. Small mass size and peripheral type might be correlated to relatively better prognosis.

Chongbiao HUANG; Liang XIN; Yan CUI; Daliang QI

2011-01-01

277

Fibrous histiocytoma of the lung.  

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A case of asymptomatic fibrous histiocytoma of the lung is described in a 14-year-old girl. A left thoracotomy was performed followed by partial resection of the lingula. Postoperative progress was uneventful.

Viguera, J L; Pujol, J L; Reboiras, S D; Larrauri, J; De Miguel, L S

278

Primary malignant fibrous histiocytoma of the abdominal cavity: CT findings and pathological correlation  

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Full Text Available AIM: To study computed tomography (CT) features of abdominal malignant fibrous histiocytoma (MFH) in various rare locations. METHODS: We retroprospectively identified cases of MFH involving the abdominal cavity. Particular attention was paid to details regarding imaging features and histological types. RESULTS: The study population consisted of seven men and one woman, with a mean age of 52.5 years. Seven patients had some physical symptoms, while one was incidentally detected. The sites of origin were liver (n = 3), greater omentum (n = 1), superior mesentery (n = 1), ileum (n = 1), right psoas muscle (n = 1) and right kidney (n = 1). With the exception of the ileum lesion, all were of huge size. The contour of the lesions was more or less clear. Foci of necrosis were present in six lesions (n = 6). On plain CT scan, all lesions were hypo to iso dense. The lesion in the greater omentum was cystic. One lesion (n = 1) showed significant enhancement and the cystic lesion showed mild peripheral enhancement. An abundance of blood vessels surrounding the mass was seen in two lesions (n = 2) and both were of the inflammatory variety. Pathological examination revealed storiform-pleomorphic variety (n = 4), inflammatory variety (n = 3) and myxoid variety (n = 1). Two of the patients with inflammatory MFH had a clinical presentation of fever and one was afebrile, however, blood investigations in all three showed leukocytosis. CONCLUSION: Primary MFHs of the abdominal viscera and gastrointestinal tract are generally huge soft tissue masses containing areas of low attenuation and mild to moderate contrast enhancement.

Bivek Karki; Yi-Kai Xu; Yuan-Kui Wu; Wei-Wei Zhang

2012-01-01

279

Angiomatoid (malignant) fibrous histiocytoma: a peculiar low-grade tumor showing immunophenotypic heterogeneity and ultrastructural variations.  

UK PubMed Central (United Kingdom)

To clarify the cellular differentiation features and facilitate diagnosis of angiomatoid (malignant) fibrous histiocytoma (AFH), four cases of AFH were examined by clinicopathologic, immunohistochemical and ultrastructural analyses. The age of the patients ranged from 10 to 24 years (mean, 17 years) and the sex distribution was equal. All cases were of subcutaneous origin: three arose in the trunk and one in the upper extremity. All patients presented with systemic symptoms, including inflammatory signs and anemia. After a mean follow up of 11 years 3 months, all patients were alive and well, although one patient twice developed local recurrence after surgery. All cases presented as multinodular, cystic and hemorrhagic tumors ranging in size from 4 to 11 cm (mean, 8 cm) and were characterized by sheets of bland spindle or round cells with oval nuclei within a circumscribed nodule often surrounded by a lymphocytic cuff. One tumor showed predominantly round cell morphology similar to Ewing's sarcoma/primitive neuroectodermal tumor. All cases (100%) exhibited immunoreactivity for vimentin, desmin, CD68 and CD57 (Leu-7). Three cases (75%) were positive for synaptophysin, and reactivity for alpha-smooth muscle actin, epithelial membrane antigen, neuron-specific enolase and CD99 (O-13) was present in two cases (50%) each. The three cases examined by electron microscopy had a mixture of fibrohistiocytic, myofibroblastic and undifferentiated cells containing cytoplasmic processes and dense-core granules. It is important for accurate diagnosis of this peculiar soft-tissue tumor to recognize that it has a variety of immunophenotypes, such as histiocytic, myofibroblastic, epithelial and neural, and may occasionally have a predominantly round cell morphology.

Hasegawa T; Seki K; Ono K; Hirohashi S

2000-09-01

280

Case report 525: Benign fibrous histiocytoma (BFH) of thumb  

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A case was presented of benign fibrous histiocytoma (BFH) involving the distal phalanx of the thumb, a location heretofore not described in the literature. The distinction between BFH and other lesions (e.g. non-ossifying fibroma) was considered in depth. The distinction between benign and malignant fibrous histiocytoma was also described. (orig.).

Statz, E.M.; Philipps, E. (Tufts-New England Medical Center, Boston, MA (USA). Dept. of Radiology); Pochebit, S.M.; Cooper, A. (Tufts-New England Medical Center, Boston, MA (USA). Dept. of Pathology); Leslie, B.M. (Tufts-New England Medical Center, Boston, MA (USA). Dept. of Orthopaedics)

1989-07-01

 
 
 
 
281

Case report 525: Benign fibrous histiocytoma (BFH) of thumb  

International Nuclear Information System (INIS)

A case was presented of benign fibrous histiocytoma (BFH) involving the distal phalanx of the thumb, a location heretofore not described in the literature. The distinction between BFH and other lesions (e.g. non-ossifying fibroma) was considered in depth. The distinction between benign and malignant fibrous histiocytoma was also described. (orig.)

1989-01-01

282

Chemically induced transplantable malignant fibrous histiocytoma of the rat. Analyses with immunohistochemistry, immunoelectron microscopy and (3H)thymidine autoradiography  

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Malignant fibrous histiocytoma was produced in rats by injection of 9,10-dimethyl-1,2-benzanthracene into their knee joints. The original tumors consisted mainly of fibroblast-like cells and histiocyte-like cells, often intermixed with bizarre giant cells, and they frequently showed the storiform-pleomorphic pattern. By immunohistochemistry, anti-rat macrophage monoclonal antibodies, TRPM-3, RM-1, and Ki-M2R, and anti-rat leukocyte common antigen reacted to the histiocyte-like cells but not to the fibroblast-like cells. By the single cell cloning method, we established six tumor cell lines, none of which reacted with the anti-rat macrophage monoclonal antibodies, possessed any Fc receptors, or conducted immune phagocytosis and Latex particle phagocytosis. The ultrastructure of the cloned tumor cells resembled that of long-term cultured dermal fibroblasts. Collagen production by the tumor cells was demonstrated immunohistochemically with a monoclonal antibody for type I collagen. Inoculation of the cloned tumor cells into rats produced tumors with the histology of malignant fibrous histiocytoma and induced prominent macrophage infiltration. In the rat tumors produced by the inoculation of (3H)thymidine labeled cells, no reactivity of tumor cells with the anti-rat macrophage monoclonal antibodies was observed. Transplantation of the cultured rat tumor cells into nude mice produced tumors similar in histology to the original rat malignant fibrous histiocytoma. Tumor cells in nude mice induced marked macrophage infiltration as detected by immunohistochemistry with the anti-mouse macrophage monoclonal antibody F4/80. No differentiation of tumor cells into macrophages was detected, since no cells were stained with biotinylated anti-rat macrophage monoclonal antibody TRPM-3.

Kato, T.; Takeya, M.; Takagi, K.; Takahashi, K. (Kumamoto Univ. Medical School (Japan))

1990-05-01

283

Chemically induced transplantable malignant fibrous histiocytoma of the rat. Analyses with immunohistochemistry, immunoelectron microscopy and [3H]thymidine autoradiography  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma was produced in rats by injection of 9,10-dimethyl-1,2-benzanthracene into their knee joints. The original tumors consisted mainly of fibroblast-like cells and histiocyte-like cells, often intermixed with bizarre giant cells, and they frequently showed the storiform-pleomorphic pattern. By immunohistochemistry, anti-rat macrophage monoclonal antibodies, TRPM-3, RM-1, and Ki-M2R, and anti-rat leukocyte common antigen reacted to the histiocyte-like cells but not to the fibroblast-like cells. By the single cell cloning method, we established six tumor cell lines, none of which reacted with the anti-rat macrophage monoclonal antibodies, possessed any Fc receptors, or conducted immune phagocytosis and Latex particle phagocytosis. The ultrastructure of the cloned tumor cells resembled that of long-term cultured dermal fibroblasts. Collagen production by the tumor cells was demonstrated immunohistochemically with a monoclonal antibody for type I collagen. Inoculation of the cloned tumor cells into rats produced tumors with the histology of malignant fibrous histiocytoma and induced prominent macrophage infiltration. In the rat tumors produced by the inoculation of [3H]thymidine labeled cells, no reactivity of tumor cells with the anti-rat macrophage monoclonal antibodies was observed. Transplantation of the cultured rat tumor cells into nude mice produced tumors similar in histology to the original rat malignant fibrous histiocytoma. Tumor cells in nude mice induced marked macrophage infiltration as detected by immunohistochemistry with the anti-mouse macrophage monoclonal antibody F4/80. No differentiation of tumor cells into macrophages was detected, since no cells were stained with biotinylated anti-rat macrophage monoclonal antibody TRPM-3

1990-01-01

284

A major response to trabectedin in metastatic malignant fibrous histiocytoma of the vertebra: a case report and review of the literature.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma is an aggressive tumor, the most common soft-tissue sarcoma of adult age. It is usually located in the extremities and retroperitoneum, and very rarely there is skeletal involvement. Surgery is the preferred treatment in early disease; in advanced disease, chemotherapy is the main therapeutic strategy. We present a 25-year-old female patient diagnosed with a vertebral mass in T5 with a severely compromised spinal cord. She underwent surgical decompression and the pathological findings were consistent with malignant fibrous histiocytoma. After several surgical treatments she had pulmonary progression and was therefore started on chemotherapy. She had a very poor response to most of the administered regimens until she initiated trabectedin 1 mg/m 2 every three weeks. She showed a significant improvement with a major response of the lung metastases. This report indicates that trabectedin is an active drug in advanced, previously treated metastatic malignant fibrous histiocytoma.

Sereno M; Merino M; Aguayo C; Hernández S; Gutiérrez-Gutiérrez G; Zambrana Tévar F; López-Gómez M; Gómez Raposo C; Casado-Sáenz E

2013-03-01

285

A major response to trabectedin in metastatic malignant fibrous histiocytoma of the vertebra: a case report and review of the literature.  

Science.gov (United States)

Malignant fibrous histiocytoma is an aggressive tumor, the most common soft-tissue sarcoma of adult age. It is usually located in the extremities and retroperitoneum, and very rarely there is skeletal involvement. Surgery is the preferred treatment in early disease; in advanced disease, chemotherapy is the main therapeutic strategy. We present a 25-year-old female patient diagnosed with a vertebral mass in T5 with a severely compromised spinal cord. She underwent surgical decompression and the pathological findings were consistent with malignant fibrous histiocytoma. After several surgical treatments she had pulmonary progression and was therefore started on chemotherapy. She had a very poor response to most of the administered regimens until she initiated trabectedin 1 mg/m 2 every three weeks. She showed a significant improvement with a major response of the lung metastases. This report indicates that trabectedin is an active drug in advanced, previously treated metastatic malignant fibrous histiocytoma. PMID:23748828

Sereno, María; Merino, María; Aguayo, Cristina; Hernández, Susana; Gutiérrez-Gutiérrez, Gerardo; Zambrana Tévar, Francisco; López-Gómez, Miriam; Gómez Raposo, César; Casado-Sáenz, Enrique

286

Aneurysmal Benign Fibrous Histiocytoma with Atrophic Features  

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Aneurysmal benign fibrous histiocytoma is an uncommon pathologic variant of dermatofibroma. In addition to the features of a typical dermatofibroma, it has large cleft-like or cavernous blood-filled spaces with numerous hemosiderin pigments. It should be differentiated from angiomatoid malignant fib...

Shin, Jung Won; Park, Hyun Sun; Kim, Byoung Kwon; Kim, Young A; Kim, Myung-Good; Won, Chong Hyun; Cho, Soyun

287

Postirradiation malignant fibrous histiocytoma of the lung. Demonstration of alpha 1-antitrypsin-like material in neoplastic cells  

International Nuclear Information System (INIS)

A metastasizing fibrous histiocytoma arising in the lung of a patient who received radiation therapy and long-term chemotherapy for malignant lymphoma is presented. Ultrastructural studies revealed fibroblast-like and histiocyte-like cells, cells of intermediate type showing ultrastructural features of both fibroblast-like and histiocyte-like cells, primitive mesenchymal cells, multinucleate tumor cells, and xanthomatous cells. The neoplastic cells showed dilated rough endoplasmic reticula with intracisternal accumulation of electron-dense material forming lattice-like structures. Direct immunofluorescence staining of the neoplastic cells using antihuman alpha 1-antitrypsin showed specific activity, with fluorescent deposits exhibiting interlacing globular formations. These findings and their implications are discussed

1980-01-01

288

Electron microscopy in the diagnosis of malignant fibrous histiocytoma of the lung presenting as metastasis to the maxillary gingiva.  

Science.gov (United States)

A rare case of an initial presentation of a metastatic lesion on the gingiva, arising from malignant fibrous histiocytoma (MFH) of the lung is reported. The role of electron microscopy in the diagnosis of soft tissue sarcomas has been studied. The ultrastructural details of a MFH are described and illustrated. The patient died within 9 weeks of the initial presentation with a gingival mass as is normal in these cases. He developed metastatic disease of the liver, lymph nodes, and bone. The role of electron microscopy in the diagnosis of soft tissue sarcomas is discussed. PMID:23092853

Thomas, M E; Koshi, R

2012-10-23

289

Electron microscopy in the diagnosis of malignant fibrous histiocytoma of the lung presenting as metastasis to the maxillary gingiva.  

UK PubMed Central (United Kingdom)

A rare case of an initial presentation of a metastatic lesion on the gingiva, arising from malignant fibrous histiocytoma (MFH) of the lung is reported. The role of electron microscopy in the diagnosis of soft tissue sarcomas has been studied. The ultrastructural details of a MFH are described and illustrated. The patient died within 9 weeks of the initial presentation with a gingival mass as is normal in these cases. He developed metastatic disease of the liver, lymph nodes, and bone. The role of electron microscopy in the diagnosis of soft tissue sarcomas is discussed.

Thomas ME; Koshi R

2013-01-01

290

Postirradiation malignant fibrous histiocytoma of the lung. Demonstration of alpha 1-antitrypsin-like material in neoplastic cells  

Energy Technology Data Exchange (ETDEWEB)

A metastasizing fibrous histiocytoma arising in the lung of a patient who received radiation therapy and long-term chemotherapy for malignant lymphoma is presented. Ultrastructural studies revealed fibroblast-like and histiocyte-like cells, cells of intermediate type showing ultrastructural features of both fibroblast-like and histiocyte-like cells, primitive mesenchymal cells, multinucleate tumor cells, and xanthomatous cells. The neoplastic cells showed dilated rough endoplasmic reticula with intracisternal accumulation of electron-dense material forming lattice-like structures. Direct immunofluorescence staining of the neoplastic cells using antihuman alpha 1-antitrypsin showed specific activity, with fluorescent deposits exhibiting interlacing globular formations. These findings and their implications are discussed.

Chowdhury, L.N.; Swerdlow, M.A.; Jao, W.; Kathpalia, S.; Desser, R.K.

1980-12-01

291

Postirradiation malignant fibrous histiocytoma. A case report with a review of postirradiation sarcoma in the Japanese literature  

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An 80-year-old Japanese woman presented a severely painful tumor on the right side of the neck. The area had been treated with radiation under a diagnosis of lymphadenitis colli tuberculosa 50 years before and then with radiation for swelling on the same site (details of the condition and the dosage of radiation were not available) for a period of one year 15 years previously. A diagnosis of postirradiation malignant fibrous histiocytoma was made. Surgery and cryosurgery were not effective and the patient died about 6 months later. A review of 25 cases of postirradiation sarcoma was made.

Okazaki, M.; Inoue, S.; Ogata, K.; Narita, H. (Miyazaki Medical Coll. (Japan))

1981-10-01

292

Benign fibrous histiocytoma of the lumbar vertebrae  

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Benign fibrous histiocytoma is an extremely rare spinal tumor with ten reported cases in the literature. Benign fibrous histiocytoma constitutes a diagnostic challenge because it shares common clinical symptoms, radiological characteristics, and histological features with other benign lesions involving the spine. We present a case of benign fibrous histiocytoma of the lumbar spine and discuss its differential diagnosis and management. (orig.)

Demiralp, Bahtiyar; Oguz, Erbil; Sehirlioglu, Ali [Gulhane Military Medical Academy, Department of Orthopedics and Traumatology, Ankara (Turkey); Kose, Ozkan [Diyarbakir Education and Research Hospital, Department of Orthopedics and Traumatology, Diyarbakir (Turkey); Ataslar Serhat Evleri, Diclekent Bulvari, Diyarbakir (Turkey); Sanal, Tuba [Gulhane Military Medical Academy, Department of Radiology, Ankara (Turkey); Ozcan, Ayhan [Gulhane Military Medical Academy, Department of Pathology, Ankara (Turkey)

2009-02-15

293

Benign fibrous histiocytoma of the lumbar vertebrae  

International Nuclear Information System (INIS)

Benign fibrous histiocytoma is an extremely rare spinal tumor with ten reported cases in the literature. Benign fibrous histiocytoma constitutes a diagnostic challenge because it shares common clinical symptoms, radiological characteristics, and histological features with other benign lesions involving the spine. We present a case of benign fibrous histiocytoma of the lumbar spine and discuss its differential diagnosis and management. (orig.)

2009-01-01

294

An adult patient who developed malignant fibrous histiocytoma 9 years after radiation therapy for childhood acute lymphoblastic leukemia  

International Nuclear Information System (INIS)

A 24-year-old Japanese man with a history of acute lymphoblastic leukemia, which occurred during childhood, developed malignant fibrous histiocytoma of his left knee. His past history revealed that he had undergone leukemic blast cell invasion of the left knee and subsequent radiation therapy 9 years ago. The total radiation doses for the upper part of the left tibia and the lower part of the left femur were 60 Gy and 40 Gy, respectively. Neither distant metastasis nor a relapse of leukemia occurred. A curative resection of the left femur with a noninvasive margin was performed. Adjuvant chemotherapy including high-dose methotrexate was given successfully before and after surgery; this was followed by relapse-free survival for 3 years. The nature of postirradiation malignant fibrous histiocytoma is highly aggressive. When a patient complains of persistent symptoms in a previously irradiated field, the possibility of this tumor must be taken into account. The importance of early diagnosis cannot be over-emphasized. (author)

2002-01-01

295

Malignant fibrous histiocytoma of the breast in young male patient: a case report and a review of the literature.  

Science.gov (United States)

MALIGNANT FIBROUS HISTIOCYTOMA (MFH) IS A FAIRLY COMMON TUMOR IN THE DEEP SOFT TISSUES: the most frequent primary sites are the lower (49%) and upper (19%) limbs, but it has been reported even in the retroperitoneum and abdomen (16%), while localization in the breast is extremely rare (1-2). Breast cancer is rarely seen in males, accounts for approximately 1% of all breast cancer, and the breast sarcomas constitute less than 1% of breast tumors in both sexes. In the review of the literature, this is the third male and first young male with MFH. Here, we present a 37-years-old male patient who is diagnosed to have malignant fibrous histiocytoma in a variant of pleomorphic fusiform cell localized in the left breast. Following the wide local excision, the patient was given an adjuvant 50?Gy of external radiotherapy. He remained alive and well after 42 months of followup. We believe that reporting such few cases would contribute to forming treatment algorithms of rare tumors. PMID:23573437

Kocak Uzel, Esengul; Figen, Metin; Bek, Tuba Tulin; Inanc, Kubilay; Onder, Senem; Kizilkaya, Hazim Orhan

2013-03-14

296

Malignant fibrous histiocytoma of the deep peri-articular tissue of the stifle in a dog : case report  

Directory of Open Access Journals (Sweden)

Full Text Available A Belgian shepherd dog aged 4 years and 9 months was presented with acute onset of non-weight bearing lameness and stifle effusion of the left hind limb, caused by the deep form of a malignant fibrous histiocytoma originating in the deep musculature and fascia surrounding the stifle joint. The tumour progressed rapidly in the tissues along the femoral diaphysis with marked periosteal new bone formation. Cytology of a stifle joint aspirate revealed numerous large polygonal neoplastic cells with considerable anisocytosis and anisokaryosis. These cells were present in clusters, with cytoplasmic projections between the cells, but occasionally also occurred singly. Several cells contained multiple cytoplasmic vacuoles and occasional giant cells were also encountered. Adequate tumour-free margins were not possible with radical limb amputation and the dog was euthanased. Macroscopically the tumour appeared as an extensive pale tan, firm mass with scattered small haemorrhages and foci of yellow discolouration. Histologically the tumour consisted of dense neoplastic expanses or multiple nodules, composed of spindle-shaped fibroblastic cells, polygonal histiocytic cells or cell clusters and scattered giant cells with 2-3 nuclei. The polygonal neoplastic cells were frequently present around and invading lymphatics and blood vessels, causing neoplastic emboli. This is the 1st report of the clinical behaviour, radiography and cytology of the deep form of malignant fibrous histiocytoma in the dog.

M.J. Booth; S.S. Bastianello; M. Jiminez; A. Van Heerden

2012-01-01

297

A new complication of retained surgical gauze: development of malignant fibrous histiocytoma – report of a case with a literature review  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Primary visceral malignant fibrous histiocytoma (MFH) is a rare disease, and few cases have been reported in the English literature. However, retained foreign bodies in the abdomen after surgical procedures are important causes of intra-abdominal infections. For legal and ethical reasons, there are few publications in the literature. In this article, we describe for the first time a case of malign abdominal fibrous histiocytoma associated with a surgical sponge forgotten in the abdominal cavity a long time ago. Case presentation A 64-year-old male presented to our surgical department with cachexia, abdominal pain, distention and pyrexia of unknown origin. He had a medical history of abdominal surgery for peptic ulcer perforation 32?years ago. Clinical examination revealed fever with a distended and painful abdominal wall. Radiological imaging of the abdomen showed multiple heterogeneous masses in one large cystic cavityalmost completely filling the abdomen. The patient underwent a laparotomy, and interestingly, opening the cyst revealed retained surgical gauze (RSG). The origin of the tumor was the visceral peritoneum, and it was excised totally. Conclusions Primary intra-abdominal MFH can present as a complication of long-lasting RSG. Therefore, clinicians must remember this while establishing the differential diagnosis for patients with a history of previous abdominal surgery and presenting with symptoms associated with both the tumor and systemic inflammatory response.

Kaplan Mehmet; ?yikö?ker Halil

2012-01-01

298

Malignant fibrous histiocytoma of the breast in young male patient: a case report and a review of the literature.  

UK PubMed Central (United Kingdom)

MALIGNANT FIBROUS HISTIOCYTOMA (MFH) IS A FAIRLY COMMON TUMOR IN THE DEEP SOFT TISSUES: the most frequent primary sites are the lower (49%) and upper (19%) limbs, but it has been reported even in the retroperitoneum and abdomen (16%), while localization in the breast is extremely rare (1-2). Breast cancer is rarely seen in males, accounts for approximately 1% of all breast cancer, and the breast sarcomas constitute less than 1% of breast tumors in both sexes. In the review of the literature, this is the third male and first young male with MFH. Here, we present a 37-years-old male patient who is diagnosed to have malignant fibrous histiocytoma in a variant of pleomorphic fusiform cell localized in the left breast. Following the wide local excision, the patient was given an adjuvant 50?Gy of external radiotherapy. He remained alive and well after 42 months of followup. We believe that reporting such few cases would contribute to forming treatment algorithms of rare tumors.

Kocak Uzel E; Figen M; Bek TT; Inanc K; Onder S; Kizilkaya HO

2013-01-01

299

Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.  

UK PubMed Central (United Kingdom)

PURPOSE: The new classification of malignant fibrous histiocytoma leaves only a small group of tumors without further line of differentiation, so-called pleomorphic sarcomas, not otherwise specified (NOS) as a pseudo-entity. This study focused on these tumors and analyzed the association of gene expression profiles to clinical outcome. MATERIALS AND METHODS: Ten fresh samples of pleomorphic NOS sarcomas were evaluated histopathologically and by means of microarray analysis. Analysis of expression profiles was performed by clustering methods as well as by statistical analysis of primary vs recurrent tumors, irradiated vs nonirradiated tumors, tumors of patients above and below 60 years of age, male and female, and of tumors that developed metastatic or recurrent disease during the clinical course and those that did not. RESULTS: Tumor clustering did not correlate to any histopathological or clinical finding. Detailed gene expression analysis showed a variety of genes whose upregulation (platelet-derived growth factor receptor alpha polypeptide, solute carrier family 39 member 14, solute carrier family 2 member 3, pleiotrophin, trophinin, pleckstrin and Sec7 domain containing 3, enolase 2, biglycan, SH3 and cysteine-rich domain, matrix metalloproteinases 16) and whose downregulation (tissue inhibitor of metalloproteinase 4, hairy/enhancer of split related with YRPW motif 2, protein tyrosine phosphatase receptor-type Z polypeptide 1, SH3 domain GRB2-like 2, microtubule-associated protein 7, potassium voltage-gated channel shaker-related subfamily member 1, RUN and FYVE domain containing 3, Sin3A-associated protein 18 kDa, proline-rich 4, calcium/calmodulin-dependent protein kinase ID, myeloid/lymphoid or mixed-lineage leukemia translocated to 3, insulin-like growth factor binding protein 5, nucleoside diphosphate-linked moiety X-type motif 9, NudC domain containing 3, imprinted in Prader-Willi syndrome, TAF6-like RNA polymerase II p300/CBP-associated factor 65 kDa, WD repeat and SOCS box-containing 2, adenosine diphosphate ribosylation factor 3, KRR1, proliferation-associated 2G4; CD36, complement component (3b/4b) receptor 1, solute carrier family 4 sodium bicarbonate cotransporter member 4, lipoprotein lipase (LPL), GATA binding protein 3, LPL, glutathione peroxidase 3, D: -aspartate oxidase, apolipoprotein E, sphingomyelin phosphodiesterase acid-like 3A) were associated with poor clinical outcome in terms of development of metastatic or recurrent disease. CONCLUSIONS: The classification of these tumors may undergo further changes in the future. Gene expression profiling can provide additional information to categorize pleomorphic sarcoma (NOS) and reveal potential prognostic factors in this "entity."

Daigeler A; Adrien D; Klein-Hitpass L; Ludger KH; Stricker I; Ingo S; Müller O; Oliver M; Kuhnen C; Cornelius K; Chromik AM; Michael CA; Steinstraesser L; Lars S; Goertz O; Ole G; Steinau HU; Hans-Ulrich S; Lehnhardt M; Marcus L

2010-03-01

300

Histiocitoma fibroso maligno de vejiga: Revisión bibliográfica/ Malignant fibrous histiocytoma of the bladder: A literature review  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Objetivos: El histiocitoma fibroso maligno (HFM) es un tumor poco frecuente del tracto urinario. Pretendemos actualizar los criterios diagnósticos, las características anatomopatológicas e inmunohistoquímicas, la clasificación histológica, los factores pronóstico y las alternativas terapéuticas. Material y métodos: Revisión bibliográfica y estudio descriptivo de los casos de HFM de vejiga publicados en la literatura médica internacional. Resultados: Existen 29 (more) casos publicados de HFM de vejiga y las variantes morfológicas más frecuentes son la estoriforme-fascicular (41%) y la inflamatoria (36%). Las variantes no mixoides comportan peor pronóstico. El 72% fue T3 en el momento del diagnóstico. La tasa de recurrencia local y a distancia del HFM de vejiga fue del 50 y del 25%, respectivamente, tras tratamiento exclusivamente quirúrgico. Conclusiones: El HFM de vejiga es un tumor con alta tasa de recurrencia local y a distancia, así como baja supervivencia, requiriendo un tratamiento precoz y agresivo. La cistectomía radical con linfadenectomía y radioterapia adyuvante, con eventual quimioterapia, se considera el tratamiento de elección. Abstract in english Objectives: Malignant fibrous histiocytoma (MFH) is an uncommon urinary tract tumor. This paper is intended to provide an update on its diagnostic criteria, pathological and immunohistochemical characteristics, histological classification, prognostic factors, and alternative treatments. Materials and methods: All published articles on MFH of the urinary bladder have been reviewed and a descriptive study has been done. Results: Twenty-nine cases of MFH of the bladder have (more) been reported. The most common morphological variants are storiform-fascicular (41%) and inflammatory (36%) MFH. Non-myxoid variants have a poorer prognosis. Stage T3 MFH was found in 72% of cases at the time of diagnosis. MFH local recurrence and distant metastasis rates were 50% and 25% respectively after surgical treatment only. Conclusions: MFH of the bladder is a tumor with high local and distant recurrence rates and a low survival rate, and therefore requires early and aggressive treatment. Radical cystectomy with lymphadenectomy and adjuvant radiotherapy is considered to be the treatment of choice, eventually associated to chemotherapy.

Povo-Martín, I.; Gallego-Vilar, D.; Bosquet-Sanz, M.; Miralles-Aguado, J.; Gimeno-Argente, V.; Rodrigo-Aliaga, M.; Gallego-Gómez, J.

2010-04-01

 
 
 
 
301

'Decoy' and 'non-decoy' functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells.  

Science.gov (United States)

Decoy receptor 3 (DcR3) is a soluble secreted protein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. DcR3 inhibits the Fas ligand (FasL)/Fas apoptotic pathway by binding to FasL, competitively with Fas receptor. Previous studies have reported that overexpression of DcR3 has been detected in various human malignancies and that DcR3 functions as a 'decoy' for FasL to inhibit FasL-induced apoptosis. In addition, recent studies have revealed that DcR3 has 'non-decoy' functions to promote tumor cell migration and invasion, suggesting that DcR3 may play important roles in tumor progression by decoy and non-decoy functions. We have previously reported that overexpression of DcR3 was observed in human malignant fibrous histiocytoma (MFH), however, the roles of DcR3 in MFH have not been studied. In the present study, to elucidate the roles of DcR3 in tumor progression of MFH, we examined the effects of DcR3 inhibition on cell apoptosis, migration and invasion in human MFH cells. siRNA knockdown of DcR3 enhanced the FasL-induced apoptotic activity and significantly decreased cell migration and invasion with a decrease in the activation of phosphatidylinositol 3 kinase (PI3K)/Akt and matrix metalloproteinase (MMP)-2. The findings in this study strongly suggest that DcR3 plays important roles in tumor progression of human MFH by decoy as well as non-decoy functions and that DcR3 may serve as a potent therapeutic target for human MFH. PMID:23817777

Toda, Mitsunori; Kawamoto, Teruya; Ueha, Takeshi; Kishimoto, Kenta; Hara, Hitomi; Fukase, Naomasa; Onishi, Yasuo; Harada, Risa; Minoda, Masaya; Kurosaka, Masahiro; Akisue, Toshihiro

2013-06-28

302

'Decoy' and 'non-decoy' functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells.  

UK PubMed Central (United Kingdom)

Decoy receptor 3 (DcR3) is a soluble secreted protein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. DcR3 inhibits the Fas ligand (FasL)/Fas apoptotic pathway by binding to FasL, competitively with Fas receptor. Previous studies have reported that overexpression of DcR3 has been detected in various human malignancies and that DcR3 functions as a 'decoy' for FasL to inhibit FasL-induced apoptosis. In addition, recent studies have revealed that DcR3 has 'non-decoy' functions to promote tumor cell migration and invasion, suggesting that DcR3 may play important roles in tumor progression by decoy and non-decoy functions. We have previously reported that overexpression of DcR3 was observed in human malignant fibrous histiocytoma (MFH), however, the roles of DcR3 in MFH have not been studied. In the present study, to elucidate the roles of DcR3 in tumor progression of MFH, we examined the effects of DcR3 inhibition on cell apoptosis, migration and invasion in human MFH cells. siRNA knockdown of DcR3 enhanced the FasL-induced apoptotic activity and significantly decreased cell migration and invasion with a decrease in the activation of phosphatidylinositol 3 kinase (PI3K)/Akt and matrix metalloproteinase (MMP)-2. The findings in this study strongly suggest that DcR3 plays important roles in tumor progression of human MFH by decoy as well as non-decoy functions and that DcR3 may serve as a potent therapeutic target for human MFH.

Toda M; Kawamoto T; Ueha T; Kishimoto K; Hara H; Fukase N; Onishi Y; Harada R; Minoda M; Kurosaka M; Akisue T

2013-09-01

303

'Decoy' and 'non-decoy' functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells  

Science.gov (United States)

Decoy receptor 3 (DcR3) is a soluble secreted protein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. DcR3 inhibits the Fas ligand (FasL)/Fas apoptotic pathway by binding to FasL, competitively with Fas receptor. Previous studies have reported that overexpression of DcR3 has been detected in various human malignancies and that DcR3 functions as a ‘decoy’ for FasL to inhibit FasL-induced apoptosis. In addition, recent studies have revealed that DcR3 has ‘non-decoy’ functions to promote tumor cell migration and invasion, suggesting that DcR3 may play important roles in tumor progression by decoy and non-decoy functions. We have previously reported that overexpression of DcR3 was observed in human malignant fibrous histiocytoma (MFH), however, the roles of DcR3 in MFH have not been studied. In the present study, to elucidate the roles of DcR3 in tumor progression of MFH, we examined the effects of DcR3 inhibition on cell apoptosis, migration and invasion in human MFH cells. siRNA knockdown of DcR3 enhanced the FasL-induced apoptotic activity and significantly decreased cell migration and invasion with a decrease in the activation of phosphatidylinositol 3 kinase (PI3K)/Akt and matrix metalloproteinase (MMP)-2. The findings in this study strongly suggest that DcR3 plays important roles in tumor progression of human MFH by decoy as well as non-decoy functions and that DcR3 may serve as a potent therapeutic target for human MFH.

TODA, MITSUNORI; KAWAMOTO, TERUYA; UEHA, TAKESHI; KISHIMOTO, KENTA; HARA, HITOMI; FUKASE, NAOMASA; ONISHI, YASUO; HARADA, RISA; MINODA, MASAYA; KUROSAKA, MASAHIRO; AKISUE, TOSHIHIRO

2013-01-01

304

Histiocitoma fibroso maligno retroperitoneal con infiltración de órganos vecinos/ Retroperitoneal malignant fibrous histiocytoma with contiguous organs infiltration  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Los tumores retroperitoneales primarios son neoformaciones extremadamente raras, de naturaleza maligna en la mayoría de los casos. Presentamos el caso de un varón de 48 años con una gran masa retroperitoneal detectada durante el estudio de un síndrome constitucional. La masa fue tratada quirúrgicamente y el diagnóstico anatomopatológico fue de histiocitoma fibroso maligno. Realizamos una revisión de la literatura y analizamos su presentación clínica, hallazgos histológicos, pruebas diagnósticas de imagen y manejo terapéutico. Abstract in english Retroperitoneal tumours are extremely rare neoplasms, most of them malignant. We described the case of a 48-year-old man with a large retroperitoneal mass detected during the study of a constitutional syndrome. The mass was treated surgerically and pathological diagnosis was malignant fibrous histiocytoma. Literature is reviewed and clinical features, histological findings, radiological techniques and therapeutic management are analyzed.

Gimeno Argente, V.; Bosquet Sanz, M.; Gómez Pérez, L.; Delgado Oliva, F.J.; Arlandis Guzmán, S.; Jiménez Cruz, J.F.

2007-05-01

305

[Transversal laryngotomy. Oncologic and functional results in laryngeal sarcoma. (Malignant fibrous histiocytoma). Case report and literature review].  

Science.gov (United States)

Sarcomas of the larynx are rare neoplasmas that consitute less than 1% of laryngeal malignancies, and their usual treatment is surgery including partial and total laryngectomy and endoscopic laser cordotomy with reported 20% recurrence. Due to previous positive experience from transversal laryngotomy in patients who underwent aritenoidectomy to treat bilateral cord paralysis after total thyroidectomy, the purpose of this work was to report on the surgical treatment of this rare case with such technique. Thus, a 47 year-old physician who complained of hoarseness for four months without dyspnea, stridor, or dysphagia and with no history of irradiation or chemotherapy was operated after both endoscopic and tomographic studies showed a 3 to 4 cm glotic tumor in its right side, with no ulceration. The pathology proved to be malignant fibrous histiocytoma. Five years after surgery the patient is alive with no evidence of disease. PMID:18524336

Pérez, Angel F; Muñoz, Rafael; Morales, Josefa; Fereira, Ennio; Colina-Chourio, José

2008-03-01

306

[Transversal laryngotomy. Oncologic and functional results in laryngeal sarcoma. (Malignant fibrous histiocytoma). Case report and literature review].  

UK PubMed Central (United Kingdom)

Sarcomas of the larynx are rare neoplasmas that consitute less than 1% of laryngeal malignancies, and their usual treatment is surgery including partial and total laryngectomy and endoscopic laser cordotomy with reported 20% recurrence. Due to previous positive experience from transversal laryngotomy in patients who underwent aritenoidectomy to treat bilateral cord paralysis after total thyroidectomy, the purpose of this work was to report on the surgical treatment of this rare case with such technique. Thus, a 47 year-old physician who complained of hoarseness for four months without dyspnea, stridor, or dysphagia and with no history of irradiation or chemotherapy was operated after both endoscopic and tomographic studies showed a 3 to 4 cm glotic tumor in its right side, with no ulceration. The pathology proved to be malignant fibrous histiocytoma. Five years after surgery the patient is alive with no evidence of disease.

Pérez AF; Muñoz R; Morales J; Fereira E; Colina-Chourio J

2008-03-01

307

Oral fibrous histiocytoma and its angiomatoid variant.  

UK PubMed Central (United Kingdom)

Fibrous histiocytomas are uncommon mesenchymal tumours of the soft tissue in the head and neck region. We report two cases that occurred in the oral cavity, one of a benign fibrous histiocytoma (BFH) and another of an angiomatoid variant of fibrous histiocytoma (AFH). BFH is a benign neoplasm composed of cells with fibroblastic and histiocytic characteristics, while AFH is considered as a distinct type of fibrous histiocytoma with an intermediate malignancy grade that combines features of both fibrohistiocytic and vascular neoplasm. We describe the clinicopathological and histological characteristics of these lesions to clarify and facilitate their diagnosis. In the BFH case, the surgical specimen had many histiocytes positive for lysozime, whereas the AFH cells showed positivity for endothelial cell marker (anti-CD34 antibody). In both cases the tumours were positive for fibronectin and negative for S100 and SMA. Ki-67. Immunohistochemistry was performed in all cases to reveal the different mitotic activity between AFH and BFH tumour cells. Finally, differential diagnoses and therapeutic treatments are discussed.

Rullo R; Ferraraccio F; Serpico R; Addabbo F; Mazzarella N; Festa VM

2012-07-01

308

Fibrous histiocytoma of the trachea.  

UK PubMed Central (United Kingdom)

The light and electron microscopic features of a fibrous histiocytoma of the trachea that occurred in a 15-year-old Caucasian girl are presented. Emphasis is placed on the aggresive behavior and the importance of early recognition of the lesion in an unusual location.

Sandstrom RE; Proppe KH; Trelstad RL

1978-09-01

309

Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma.  

UK PubMed Central (United Kingdom)

Epithelioid hemangioendothelioma is a relatively uncommon lesion usually presenting in soft tissues. The occurrence in the mediastinum is exceptional rare. Histologically, this tumor is characterized by epithelioid cells with intracytoplasmic vacuole s in a hyalinized or mucinous stroma. Occasionally, spindle cells or osteoclast-like giant cel ls can be observed. Herein, we present a case of epithelioid hemangioendothelioma in a 38 year-old Chinese male. The tumor was predominantly composed of abundant spindle cells with marked atypia and scattered osteoclast-like giant cells reminiscent of malignant fibrous histiocytoma. The unusual histological appearance can pose a great diagnostic challenge. It may be easily misdiagnosed, especially if the specimen is limited or from fine-needle aspiration. Virtual slides http://www.diagnosticpathology.diagnomx.eu/vs/8287357528177060.

Li XM; Lin XY; Xu HT; Yu JH; Wang L; Fan CF; Liu Y; Wang EH

2013-06-01

310

Malignant fibrous histiocytoma of the distal femur after an arthroscopic anterior cruciate ligament reconstruction: A case report and a review of the literature  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Malignant degeneration in association with orthopaedic implants is a known but rare complication. To our knowledge, no case of osseous malignant fibrous histiocytoma after anterior cruciate ligament reconstruction is reported in the literature. Case presentation We report a 29-year-old male Turkish patient who presented with severe pain in the operated knee joint 40 months after arthroscopic anterior cruciate ligament reconstruction. X-ray and MR imaging showed a large destructive tumor in the medial femoral condyle. Biopsy determined a malignant fibrous histiocytoma. After neoadjuvant chemotherapy, wide tumor resection and distal femur reconstruction with a silver-coated non-cemented tumor knee joint prosthesis was performed. Adjuvant chemotherapy was continued according to the EURAMOS 1 protocol. Conclusions Though secondary malignant degeneration after orthopaedic implants or prostheses is not very likely, the attending physician should take this into consideration, especially if symptoms worsen severely over a short period of time.

Efe Turgay; Heyse Thomas J; Schofer Markus D; Fuchs-Winkelmann Susanne; Rexin Peter; Schmitt Jan

2010-01-01

311

Oral benign fibrous histiocytoma: two case reports  

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Fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body. The involvement of the oral cavity is rare. We report two cases of benign fibrous histiocytoma that localized in the oral cavity. The clinical and histological features of the lesion are repor...

Menditti, Dardo; Laino, Luigi; Mezzogiorno, Antonio; Sava, Sara; Bianchi, Alexander; Caruso, Giovanni; Di Maio, Luigi

312

Atypical Cutaneous Fibrous Histiocytoma: An Unusual and Misleading Variant of Fibrous Histiocytoma  

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Atypical fibrous histiocytoma is a distinctive variant of cutaneous fibrous histiocytoma, which is often mistaken histologically for sarcoma and which have a tendency to recur locally and a capacity to metastasize, although very rarely. We report a new case of atypical cutaneous fibrous histiocytoma...

Ben Abdelkrim, Soumaya; Belajouza, Colondane; Jomaa, Wafa; Beizig, Nadia; Ben Said, Zeineb; Mokni, Moncef; Nouira, Rafia

313

Benign fibrous histiocytoma of the small intestine in a cow.  

UK PubMed Central (United Kingdom)

A well circumscribed, firm nodule was found protruding from the duodenal wall of an adult cow at routine meat inspection. On the basis of morphological and immunophenotypic features, a diagnosis of benign fibrous histiocytoma (BFH) was established. Malignant fibrous histiocytoma has been reported previously in the cow, albeit rarely, but to the best of our knowledge this is the first recorded case of bovine intestinal BFH.

Salvaggio A; Caracappa S; Marino AM; Magro G

2004-02-01

314

Histiocitoma fibroso maligno de orofaringe: Resección y reconstrucción con colgajo fasciocutáneo radial/ Malignant oropharyngeal fibrous histiocytoma: Resection and radial reconstruction with fasciocutaneous flap  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish El histiocitoma fibroso maligno se reconoce como el sarcoma de tejidos blandos más frecuente de la edad adulta, aunque su localización en faringe no es usual habiéndose recogido en la literatura científica tan solo 6 casos en esta localización. Presentamos el caso de un paciente con un histiocitoma fibroso maligno en orofaringe de gran tamaño, al que se le realizó una resección con amplios márgenes y la reconstrucción del defecto con un colgajo fasciocutáneo ra (more) dial. Discutiremos a raíz del caso la epidemiología, manifestaciones clínicas, incidencia de metástasis, histopatología, factores pronósticos y tratamiento de este tipo de tumores. Abstract in english Malignant fibrous histiocytoma is recognized as the most common soft-tissue sarcoma in adults, although its location in the pharynx is unusual. Only 6 cases of the pharynx have been reported in the scientific literature. We report the case of a patient with a large malignant fibrous histiocytoma in the oropharynx. The tumor was resected with generous margins and the defect was reconstructed with a radial fasciocutaneous flap. The epidemiology, clinical manifestations, inc (more) idence of metastases, histopathology, prognostic factors and treatment of malignant fibrous histiocytoma are discussed in relation to this case.

García Monleón, L.; Acero Sanz, J.; Amo Fernández de Velasco, Á. del; Ochandiano Caicoya, S.; López de Atalaya, J.; Navarro Vila, C.

2008-04-01

315

Histiocitoma fibroso maligno de orofaringe: Resección y reconstrucción con colgajo fasciocutáneo radial Malignant oropharyngeal fibrous histiocytoma: Resection and radial reconstruction with fasciocutaneous flap  

Directory of Open Access Journals (Sweden)

Full Text Available El histiocitoma fibroso maligno se reconoce como el sarcoma de tejidos blandos más frecuente de la edad adulta, aunque su localización en faringe no es usual habiéndose recogido en la literatura científica tan solo 6 casos en esta localización. Presentamos el caso de un paciente con un histiocitoma fibroso maligno en orofaringe de gran tamaño, al que se le realizó una resección con amplios márgenes y la reconstrucción del defecto con un colgajo fasciocutáneo radial. Discutiremos a raíz del caso la epidemiología, manifestaciones clínicas, incidencia de metástasis, histopatología, factores pronósticos y tratamiento de este tipo de tumores.Malignant fibrous histiocytoma is recognized as the most common soft-tissue sarcoma in adults, although its location in the pharynx is unusual. Only 6 cases of the pharynx have been reported in the scientific literature. We report the case of a patient with a large malignant fibrous histiocytoma in the oropharynx. The tumor was resected with generous margins and the defect was reconstructed with a radial fasciocutaneous flap. The epidemiology, clinical manifestations, incidence of metastases, histopathology, prognostic factors and treatment of malignant fibrous histiocytoma are discussed in relation to this case.

L. García Monleón; J. Acero Sanz; Á. del Amo Fernández de Velasco; S. Ochandiano Caicoya; J. López de Atalaya; C. Navarro Vila

2008-01-01

316

Primary inflammatory malignant fibrous histiocytoma of the breast: a case report of an unusual variant and review of the literature.  

Science.gov (United States)

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma of adults, but its presence in the breast is rare. We report a case of primary inflammatory MFH in a 72-year-old Caucasian female with no previous medical history and no prior radiation exposure. She presented with a palpable mass that was suspicious for malignancy on mammography. Histologic evaluation of the core needle biopsy revealed sheets of large, pleomorphic neoplastic cells within a dense background of acute and chronic inflammatory cells. The neoplastic cells exhibited a moderate to abundant amount of finely vacuolated cytoplasm and atypical nuclei with vesicular nuclear chromatin and prominent nucleoli. Mitotic activity was readily identified, and foci of necrosis were noted. The neoplastic cells were immunoreactive with CD68, alpha 1-antitrypsin, alpha 1-antichymotrypsin, and vimentin. The diagnosis of MFH was rendered after thorough microscopic examination of the entire mass following mastectomy. MFH of the breast is a diagnosis of exclusion. The definitive treatment of MFH is surgical, either with wide local excision or total mastectomy. The roles of sentinel lymph node biopsy, axillary lymph node dissection, chemotherapy, and radiation have yet to be definitively clarified. The prognosis of MFH of the breast is generally poor. PMID:23827212

Tashjian, Randy; Gilani, Syed M; Falk, Jeffery; Kelly, Michael J; Ockner, Daniel; Danforth, Robert

2013-06-06

317

Primary inflammatory malignant fibrous histiocytoma of the breast: a case report of an unusual variant and review of the literature.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma of adults, but its presence in the breast is rare. We report a case of primary inflammatory MFH in a 72-year-old Caucasian female with no previous medical history and no prior radiation exposure. She presented with a palpable mass that was suspicious for malignancy on mammography. Histologic evaluation of the core needle biopsy revealed sheets of large, pleomorphic neoplastic cells within a dense background of acute and chronic inflammatory cells. The neoplastic cells exhibited a moderate to abundant amount of finely vacuolated cytoplasm and atypical nuclei with vesicular nuclear chromatin and prominent nucleoli. Mitotic activity was readily identified, and foci of necrosis were noted. The neoplastic cells were immunoreactive with CD68, alpha 1-antitrypsin, alpha 1-antichymotrypsin, and vimentin. The diagnosis of MFH was rendered after thorough microscopic examination of the entire mass following mastectomy. MFH of the breast is a diagnosis of exclusion. The definitive treatment of MFH is surgical, either with wide local excision or total mastectomy. The roles of sentinel lymph node biopsy, axillary lymph node dissection, chemotherapy, and radiation have yet to be definitively clarified. The prognosis of MFH of the breast is generally poor.

Tashjian R; Gilani SM; Falk J; Kelly MJ; Ockner D; Danforth R

2013-08-01

318

Benign Fibrous Histiocytoma of the Maxillary Sinus  

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Fibrous Histiocytoma is an uncommon neoplasm of the Head and Neck region and quite rare in the paranasal sinuses. We are reporting a case of Benign Fibrous Histiocytoma in the Maxillary sinus from the Department of Otorhinolaryngology of Bolani Hospital, Bolani with a description of clinical and his...

Singh, Mangal

319

Benign fibrous histiocytoma of the conjunctiva.  

UK PubMed Central (United Kingdom)

A case is reported on recurrence of a rare conjunctival fibrous histiocytoma (FH) in a 38-year-old man. The lesion was excised and subsequently sent for histopathology and immunostaining resulting in a diagnosis of fibrous histiocytoma (FH). Recurrence was detected 3 months postoperatively requiring a conjunctivosclerokeratomy with cryotherapy and flap. At 6-month followup there was no recurrence detected.

Ryan G; Glasson B; Foster A

2012-01-01

320

Identification of sequence polymorphisms in the D-loop region of mitochondrial DNA as risk biomarkers for malignant fibrous histiocytoma.  

UK PubMed Central (United Kingdom)

Abstract Single nucleotide polymorphisms (SNPs) in the mitochondrial DNA Displacement-loop (D-loop) region particularly in a highly polymorphic homopolymeric C stretch named D310 have been reported to be associated with cancer risk in several types of cancer. In order to evaluate the frequency of D-loop SNPs in a large series of malignant fibrous histiocytoma (MFH) and establish correlations with cancer risk, we sequenced the D-loop of 92 MFH patients and analyzed their use as predictive biomarkers for MFH risk. The minor alleles of nucleotides 73G, 151T were associated with an increased risk for MFH patients, whereas the alleles of nucleotides 16,298C, 152C, and insertion of C at the site 315 (located within the D310) were associated with a decreased risk for MFH patients. These results suggest that SNPs in the mitochondrial D-loop should be considered as a biomarker which may be useful for the early detection of MFH in individuals at risk of this cancer.

Xun J; Li Z; Song X; Wang X

2013-10-01

 
 
 
 
321

Angioarchitecture of Tumors Induced by Two Different Cloned Cell Lines Established from a Transplantable Rat Malignant Fibrous Histiocytoma  

Science.gov (United States)

Angiogenesis, a biologic process whereby endothelial cells divide and migrate to form new blood vessels, is a key step in tumor growth, invasion, and metastasis. In the present study, we investigated the differences in angioarchitecture between two different tumors induced by cloned cell lines (MT-8 and MT-9), derived from a transplantable rat malignant fibrous histiocytoma, by scanning electron microscopy of vascular corrosion casts. During a 3-week observation period after implantation, the growth of MT-8 tumors appeared to be faster than that of MT-9 tumors. Histologically, MT-8 tumors were of the uniformly undifferentiated sarcoma type arranged in characteristic organoid structures, and MT-9 tumors showed a storiform growth pattern. In MT-8 tumors, neovascularization occurred by sprouting at postimplantation (PI) week 1, and the newly formed capillaries gradually became more tortuous. In MT-9 tumors, at PI week 1, the corrosion casts of newly formed capillaries mainly showed a wavy course but no fingerlike outgrowths of capillaries were seen. At PI weeks 2 and 3, the sprouting was seen specifically in MT-9 tumors, forming basketlike structures and glomeruloid structures of capillaries. These results indicate that angiogenesis or angioarchitecture of MT-8 tumors is different from that of MT-9 tumors, depending on the differences in their tumor histology and by the features like absence or presence of basketlike structures and glomeruloid structures of capillaries.

Tsunenari, Ichiro; Yamate, Jyoji; Iwaki, Masae; Kuwamura, Mitsuru; Kotani, Takao; Sakuma, Sadashige

2003-12-01

322

Benign fibrous histiocytoma of the retroperitoneum  

International Nuclear Information System (INIS)

A case of benign fibrous histiocytoma of the retroperitoneum accidentally found on ultrasound in a fifty-six year old woman is reported. Diagnosis and differential diagnosis in special consideration or radiological methods are discussed. (orig.)

1993-01-01

323

Clonal T-cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206.  

UK PubMed Central (United Kingdom)

Towards the goal of identifying tumor-rejection antigens on eradicated tumors in bone and soft tissue sarcomas, we evaluated the immune response against antigens presented by lost HLA class I molecules. Tumor specimens and peripheral blood samples were obtained from a 70-year-old woman with pleomorphic malignant fibrous histiocytoma. Over 1-year culture, a tumor cell line (MFH2004) was established. A B-cell line infected with Epstein-Barr virus (B2004-EBV) was developed from the blood samples. HLA genotypes of B2004-EBVcells were A*0206/2402, B*4006/4601, and C*0102/0801, whereas MFH2004 cells were defective for A*0206, B*4006, and C*0102. Loss of HLA-A2 expression was also proved immunohistochemically in the primary tumor tissues. Lost HLA-A2 in MFH2004 cells was retrieved by transfection of HLA-A*0206 cDNA to develop MFH2004-A2. Attempts to induce CTLs by mixed culture with autologous T cells and MFH2004 cells resulted in failure. In contrast, those with MFH2004-A2 induced CTL clones CTL2004-c6 and CTL2004-c17. These CTL clones specifically killed MFH2004-A2 but not MFH2004 or B2004-EBV in an HLA-A2-restricted manner. These findings suggest that CTL2004-c6 and CTL2004-c17 recognize autologous tumor-rejection antigens presented by HLA-A*0206, which may have been expressed by tumor cells that had been eradicated by the host's immunosurveillance system.

Kimura S; Kozakai Y; Kawaguchi S; Tsukahara T; Ida K; Murase M; Matsumura T; Kaya M; Torigoe T; Wada T; Sato N; Yamashita T

2008-02-01

324

Primary malignant fibrous histiocytoma of the pleura - a radiological finding; Fibro-histiocitoma maligno primario da pleura - relato de um caso  

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The authors report a case of pleural malignant fibrous histiocytoma with lung invasion in a 31-year-old woman. The origin of the tumor was identified chest roentgenograms and computed tomography showing a mass in the horizontal fissure and part of the oblique fissure, after an episode of acute pneumonia. The patient had a middle lobectomy and segmentectomy of the right upper lobe. She had local recurrence three months after surgery, receiving after that chemotherapy and radiation therapy. (author) 18 refs., 4 figs.

Dinoa, Vanessa de Albuquerque; Teixeira, Sonia Marcelino; Borges, Aurea Valeria Rosa Mohana [Hospital Universitario Antonio Pedro, Niteroi, RJ (Brazil). Dept. de Radiologia; Marchiori, Edson [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Inst. Biomedico. Dept. de Radiologia; Judice, Angelo Mesquita [Hospital Universitario Antonio Pedro, Niteroi, RJ (Brazil). Servico de Cirurgia Toracica; Moraes, Heleno Pinto de [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Inst. Biomedico. Dept. de Patologia

1996-11-01

325

Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report  

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Abstract Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmona...

Bohn Olga L; de León Eric; Lezama Oscar; Rios-Luna Nina P; Sánchez-Sosa Sergio; Llombart-Bosch Antonio

326

Benign fibrous histiocytoma of the cheek.  

UK PubMed Central (United Kingdom)

Benign fibrous histiocytoma (FH) is a benign neoplasm of a mixture of fibroblastic and histiocytic cells. The tumor occurs most frequently on the skin of the extremities but rarely in deep soft tissues of the head and neck. The diagnosis of benign FH may be clinically difficult, and is frequently confirmed after excision. The most important diagnostic distinction is the separation of this tumor from malignant FH. A 22-year-old male presented with a painless swelling mass on the left cheek. Detailed clinical and laboratory examinations were performed. The patient received angiography with embolization and underwent an intraoral excision of the mass under general anesthesia with primary closure. The histopathology revealed a benign FH. The complete image survey and appropriate treatment of benign FH of the cheek are emphasized.

Ding YF; Hao SP

2013-03-01

327

Benign fibrous histiocytoma of the cheek.  

Science.gov (United States)

Benign fibrous histiocytoma (FH) is a benign neoplasm of a mixture of fibroblastic and histiocytic cells. The tumor occurs most frequently on the skin of the extremities but rarely in deep soft tissues of the head and neck. The diagnosis of benign FH may be clinically difficult, and is frequently confirmed after excision. The most important diagnostic distinction is the separation of this tumor from malignant FH. A 22-year-old male presented with a painless swelling mass on the left cheek. Detailed clinical and laboratory examinations were performed. The patient received angiography with embolization and underwent an intraoral excision of the mass under general anesthesia with primary closure. The histopathology revealed a benign FH. The complete image survey and appropriate treatment of benign FH of the cheek are emphasized. PMID:23218719

Ding, Yi-Fang; Hao, Sheng-Po

2012-12-04

328

A new complication of retained surgical gauze: development of malignant fibrous histiocytoma--report of a case with a literature review.  

UK PubMed Central (United Kingdom)

BACKGROUND: Primary visceral malignant fibrous histiocytoma (MFH) is a rare disease, and few cases have been reported in the English literature. However, retained foreign bodies in the abdomen after surgical procedures are important causes of intra-abdominal infections. For legal and ethical reasons, there are few publications in the literature. In this article, we describe for the first time a case of malign abdominal fibrous histiocytoma associated with a surgical sponge forgotten in the abdominal cavity a long time ago. CASE PRESENTATION: A 64-year-old male presented to our surgical department with cachexia, abdominal pain, distention and pyrexia of unknown origin. He had a medical history of abdominal surgery for peptic ulcer perforation 32 years ago. Clinical examination revealed fever with a distended and painful abdominal wall. Radiological imaging of the abdomen showed multiple heterogeneous masses in one large cystic cavityalmost completely filling the abdomen. The patient underwent a laparotomy, and interestingly, opening the cyst revealed retained surgical gauze (RSG). The origin of the tumor was the visceral peritoneum, and it was excised totally. CONCLUSIONS: Primary intra-abdominal MFH can present as a complication of long-lasting RSG. Therefore, clinicians must remember this while establishing the differential diagnosis for patients with a history of previous abdominal surgery and presenting with symptoms associated with both the tumor and systemic inflammatory response.

Kaplan M; Iyikö?ker HI

2012-01-01

329

Eight-year follow-up of malignant fibrous histiocytoma (undifferentiated high-grade pleomorphic sarcoma) of the maxilla: case report and review of the literature  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma of late adult life and may also arise as a primary tumor in bone. It is a rare condition that constitutes less than 1% of the malignant tumors of bone and commonly occurs in the mathaphysis of long bones of extremities such as the femur and tibia. The occurrence in the head and neck region is very rare. MFH of the jaws is a highly malignant tumor that recurs, metastasizes, and usually causes death despite aggressive surgical therapy. We present a case of MFH of maxilla with 8 years follow-up. The clinical, pathologic and radiographic features as well as the treatment of this case are discussed.

Hossein Shahoon; Mostafa Esmaeili; Mahsa Nematollahi

2009-01-01

330

Angiomatoid "malignant" fibrous histiocytoma: a clinicopathologic study of 158 cases and further exploration of the myoid phenotype.  

UK PubMed Central (United Kingdom)

Angiomatoid "malignant" fibrous histiocytoma (AMFH) has been considered to be a low-grade sarcoma of childhood, and, with its fibrous pseudocapsule, angiomatoid change, dense lymphoplasmacytic response, and proliferation of spindled or round cells, has been classified as a fibrohistiocytic neoplasm. We wanted to study the clinicopathologic and immunophenotypic features of a large number of these tumors and to especially further explore their myoid differentiation. Cases coded as AMFH from 1979 to 1995 were retrieved from the Soft Tissue Registry of the AFIP. Only cases that met the criteria for AMFH by light microscopy were included, a total of 158 cases. Immunohistochemistry was obtained on 98 cases. Clinical history on 92% of all cases revealed a gender ratio of 1.3 females: males, age range of 2 to 71 years, median size of 2.0 cm, and a distribution of extremities > trunk > head and neck, with 66% lesions occurring in areas of normal lymphoid tissue. All tumors with available margins were well-circumscribed. Eighty percent of cases had some degree of lymphoplasmacytic infiltration; 50% cases had pseudovascular spaces filled with blood. Fifty-two percent had predominantly round cell morphology; 48% had a predominantly spindle cell pattern. Desmin positivity was noted in 51% cases and occurred in both predominantly round cell and spindle cell tumors. Most of the desmin-positive cases with adjacent lymphoid infiltrate (67%) showed scattered similar, desmin-positive cells in the surrounding lymphoid infiltrate, adjacent to the tumor. Muscle-specific and smooth-muscle actins were seen in 14% cases. Heavy-caldesmon was strongly positive in 3%, and calponin was focally positive in 73% and extensively positive in 12% cases. MyoD1, myoglobin, and myogenin (myf4) were negative in all tumors studied. Forty-five percent of cases were positive for CD99; 52% of these had round cell morphology. Fifteen percent of cases were positive for KP-1. All tumors were positive for vimentin and negative for CD21, CD35, S100 protein, CD34, keratins 8/18, and lysozyme. Clinical follow-up on 86 patients indicated that only 1 patient was alive with a local nodal metastasis (1% frequency of metastasis) within 1 year, and 2 others had local recurrence, all over a mean follow-up period of 6 years. The myoid, primarily myofibroblastic, phenotype of these lesions is supported by desmin, calponin, and occasional actin positivity. The occasional heavy-caldesmon and smooth muscle actin additionally suggest rare smooth muscle phenotype; however, lack of skeletal muscle markers indicate no relationship of AMFH to skeletal muscle tumors. The resemblance of these lesions to lymph nodes, clinically and morphologically, the finding of similar desmin positive cells in the adjacent lymphoid infiltrate, and the fact that 66% cases were found in sites of normal lymphoid tissue raise the possibility that some of these lesions may arise from or be related to myoid cells of lymphoid tissue. AMFH has an almost invariably benign behavior, but the 1% metastatic rate warrants its classification as low-grade "malignant." The predominantly round cell, CD99-positive and desmin positive AMFH cases, respectively, should not be confused with Ewing's sarcoma/PNET or rhabdomyosarcoma, respectively.

Fanburg-Smith JC; Miettinen M

1999-11-01

331

Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses. The patient had no other primary malignant neoplasm, thus excluding a metastatic lesion. Gross examination revealed a thickened right pulmonary artery and a necrotic and hemorrhagic tumor, filling and occluding the vascular lumen. The mass extended distally, within the pulmonary vasculature of the right lung. Microscopically, an intravascular undifferentiated tumor was identified. The tumor cells showed expression for vascular markers VEGFR, VEGFR3, PDGFRa, FGF, Ulex europaeus, FVIII, FLI-1, CD31 and CD34; p53 was overexpressed and Ki67 proliferative rate was increased. Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome. Virtual slide The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2315906377648045.

Bohn Olga L; de León Eric; Lezama Oscar; Rios-Luna Nina P; Sánchez-Sosa Sergio; Llombart-Bosch Antonio

2012-01-01

332

Benign fibrous histiocytoma of the femur: review of three cases  

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Objective. Benign fibrous histiocytoma is a tumor with histologic features similar to those of xanthofibromas, which include fibrous cortical defects and nonossifying fibromas, but with different clinical features. This study investigated the findings of benign fibrous histiocytoma on various imaging modalities. It emphasized the importance of clinical and imaging features as well as histologic findings in establishing the diagnosis. Design. We reviewed three cases of benign fibrous histiocytoma of the femur that had been diagnosed histologically as (fibro)xanthoma during a retrospective analysis of 187 primary benign and malignant bone lesions. Patients. All the patients were middle-aged women with various knee complaints. Results and conclusions. Radiologically, the lesions were all lytic with well-defined geographic margins and sclerotic rims. The tumors arose within the medullary cavity in the distal metaphysis of the femur and involved the epiphysis. CT showed lytic destruction with well-defined marginal sclerosis. T1-weighted MR images showed that the lesions had predominantly the same signal intensity as that of skeletal muscle. The lesions were hypovascular on angiography. Bone scintigraphy showed moderately increased uptake. It was concluded that multiple images as well as clinical features can be useful in differentiating benign fibrous histiocytoma from fibroxanthoma, giant cell tumor, and other fibrohistiocytic tumors of bone. (orig.)

Hamada, T. [Kinki Univ. School of Medicine, Osaka (Japan). Dept. of Radiology; Ito, H. [Kinki Univ., Osaka (Japan). Div. of Pathology; Araki, Y. [Kinki Univ. School of Medicine, Osaka (Japan). Dept. of Radiology; Fujii, K. [Kinki Univ. School of Medicine, Osaka (Japan). Dept. of Radiology; Inoue, M. [Kinki Univ. School of Medicine, Osaka (Japan). Dept. of Radiology; Ishida, O. [Kinki Univ. School of Medicine, Osaka (Japan). Dept. of Radiology

1996-01-01

333

Imaging of soft tissue malignant fibrous histiocytoma; Place de l`imagerie dans le bilan des histiocytomes fibreux malins des parties molles  

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Malignant fibrous histiocytoma (MFH) is a rare and potentially highly malignant sarcoma. The authors report 6 cases of MFH in various sites : two in the chest wall, one in the pelvis, two in the gluteal zones and one on the scalp. Ultrasonography and computed tomography were the main imaging methods used in the assessment of the structure and extension of the tumor. A poor prognosis was noted in four cases: death within a few months in the two thoracic sites, recurrence in the pelvic and scalp lesions, radical surgery allowed recovery in two cases. A review of the literature showed that MRI and CT are complementary in the initial staging and follow-up these patients. (author)

Jemni, H.; Bakir, D.; Ben Ahmed, S.; Kraiem, C. [Centre Hospitalier Universitaire F. Hached, Sousse (Tunisia); Mrad Dali, K.; Tlili-Graiess, K.; Mnif, Z.; Jeddi, M. [Centre Hospitalier Universitaire Sahloul, Sousse (Tunisia)

1996-12-31

334

Case report 465: Benign fibrous histiocytoma (BFH)  

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In summary a case has been presented of an osteolytic lesion in the distal end of the femur with a pathological fracture in a 33-year-old man. The lesion appeared radiologically benign, although aggresive. A biopsy of curetted material showed the stigmata of benign fibrous histiocytoma. The clinical, radiological, and pathological aspects of BFH were discussed and the close relationship to NOF was considered. A typical fibrous histiocytoma was also described. The suggestion was made that BFH and NOF may constitute a spectrum of the same disorder. (orig./SHA).

Hermann, G.; Sherry, H.H.; Steiner, G.C.

1988-04-01

335

Case report 465: Benign fibrous histiocytoma (BFH)  

International Nuclear Information System (INIS)

In summary a case has been presented of an osteolytic lesion in the distal end of the femur with a pathological fracture in a 33-year-old man. The lesion appeared radiologically benign, although aggresive. A biopsy of curetted material showed the stigmata of benign fibrous histiocytoma. The clinical, radiological, and pathological aspects of BFH were discussed and the close relationship to NOF was considered. A typical fibrous histiocytoma was also described. The suggestion was made that BFH and NOF may constitute a spectrum of the same disorder. (orig./SHA)

1988-01-01

336

Benign fibrous histiocytoma of the bladder  

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Mesenchymal tumors of the bladder are rare with leiomyoma accounting for most of these. We present a rare case of a bladder benign fibrous histiocytoma in a 52-year-old male. He presented with history of straining during micturition since two years. The magnetic resonance imaging revealed a large in...

De Padua, Michelle; Subramanium, N.

337

Indium-111-labeled leukocyte and technetium-99m-sulfur colloid uptake by a malignant fibrous histiocytoma: Phagocytosis by tumor cells  

International Nuclear Information System (INIS)

Indium-111-labeled leukocyte imaging, performed on a patient with a calcified mass in the right thigh, demonstrated labeled leukocyte accumulation in this mass. Technetium-99m-sulfur colloid imaging was performed to differentiate labeled leukocyte uptake in heterotopic bone marrow from uptake in a focus of infection. Leukocyte and sulfur colloid images were virtually identical, and the study was interpreted as without evidence of infection. Excision of the mass revealed an angiomatoid malignant fibrous histiocytoma with metaplastic bone formation. While no marrow elements were present in either the tumor or the metaplastic bone, phagocytosis of leukocytes by tumor cells was identified. Phagocytosis of leukocytes by tumor cells may be another cause of white cell accumulation in uninfected neoplasms

1990-01-01

338

Malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the maxillary sinus : report of a case and review of the literature.  

Science.gov (United States)

Malignant fibrous histiocytoma (MFH) also known as undifferentiated high-grade pleomorphic sarcoma (UHPS) is a soft tissue sarcoma, composed of undifferentiated mesenchymal tumors possessed fibrohistiocytic morphology without definite true histiocytic differentiation. Head and neck localization is very rare, showing an incidence ranging from 4 % to 10 % in different series of investigations. The most frequent involved sites in UHPS are the neck and parotid, followed by the scalp, face, anterior skull base and orbit. Upper aerodigestive tract, lateral skull base and ear are rare locations. The incidence of the lymphatic metastases is also rare. The aim of this article is to report a case of UHPS in the maxillary sinus with palatal, orbital and ethmoidal involvement, with lymphatic metastasis and its surgical treatment. In addition, we review the literature of similar cases of the past 12 years. PMID:23812657

Vuity, Drazsen; Bogdan, Sandor; Csurgay, Katalin; Sapi, Zoltan; Nemeth, Zsolt

2013-06-29

339

Indium-111-labeled leukocyte and technetium-99m-sulfur colloid uptake by a malignant fibrous histiocytoma: Phagocytosis by tumor cells  

Energy Technology Data Exchange (ETDEWEB)

Indium-111-labeled leukocyte imaging, performed on a patient with a calcified mass in the right thigh, demonstrated labeled leukocyte accumulation in this mass. Technetium-99m-sulfur colloid imaging was performed to differentiate labeled leukocyte uptake in heterotopic bone marrow from uptake in a focus of infection. Leukocyte and sulfur colloid images were virtually identical, and the study was interpreted as without evidence of infection. Excision of the mass revealed an angiomatoid malignant fibrous histiocytoma with metaplastic bone formation. While no marrow elements were present in either the tumor or the metaplastic bone, phagocytosis of leukocytes by tumor cells was identified. Phagocytosis of leukocytes by tumor cells may be another cause of white cell accumulation in uninfected neoplasms.

Palestro, C.J.; Klein, M.; Kim, C.K.; Swyer, A.J.; Goldsmith, S.J. (Mt Sinai School of Medicine, New York, NY (USA))

1990-09-01

340

Calculation of probability of causation for non-specified radiogenic cancer cases. Etiologic judgement of a malignant fibrous histiocytoma developed at the elbow of a plutonium contaminated worker  

International Nuclear Information System (INIS)

A criterion for the compensation of patients with radiogenic cancer has been formulated for five specified cancers. A method of calculation of the probability of causation (PC) of non-specified cancers was applied to a case of malignant fibrous histiocytoma developed at the elbow of a plutonium contaminated worker. According to the histologic structure of the tumour, there were three possible target cells, and their doses were evaluated with the available data of urine plutonium. Then PC was calculated with excess relative risk coefficient indirectly deduced from related animal experiment. The result showed that the obtained PC varied greatly with the supposed target cells. If the target cells were periosteum cells, the PC might exceed 50 percent, but that might not be true, and the tumour might come from fibroblasts, and then PC might be less than 1 percent

1995-01-01

 
 
 
 
341

Malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the maxillary sinus : report of a case and review of the literature.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma (MFH) also known as undifferentiated high-grade pleomorphic sarcoma (UHPS) is a soft tissue sarcoma, composed of undifferentiated mesenchymal tumors possessed fibrohistiocytic morphology without definite true histiocytic differentiation. Head and neck localization is very rare, showing an incidence ranging from 4 % to 10 % in different series of investigations. The most frequent involved sites in UHPS are the neck and parotid, followed by the scalp, face, anterior skull base and orbit. Upper aerodigestive tract, lateral skull base and ear are rare locations. The incidence of the lymphatic metastases is also rare. The aim of this article is to report a case of UHPS in the maxillary sinus with palatal, orbital and ethmoidal involvement, with lymphatic metastasis and its surgical treatment. In addition, we review the literature of similar cases of the past 12 years.

Vuity D; Bogdan S; Csurgay K; Sapi Z; Nemeth Z

2013-10-01

342

A case of radiation-induced sternal malignant fibrous histiocytoma treated with neoadjuvant chemotherapy and surgical resection  

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Full Text Available Abstract Background Primary sternal malignant fibrous histiyocytoma (MFH) is highly rare. Effective treatment modality is surgical resection with wide margins. However, to date, the effects of radiotherapy or chemotherapy has not been clearly defined. Case presentation Herein, we aimed to present a 50-year old female patient with MFH occurred in the radiotherapy field who had had surgical procedure for breast cancer 19 years ago and had followed by radiotherapy. Neoadjuvant chemotherapy was applied for MFH due to cardiac and mediastinal vascular invasion. Wide resection was carried out for the mass after having been decreased in size following neoadjuvant chemotherapy. Conclusion Neoadjuvant chemotherapy was an effective method. In planning the surgical resection, the size of the tumor before chemotherapy should be considered as the initial size and surgical margins should be determined accordingly.

Kocer Bulent; Gulbahar Gultekin; Erdogan Bulent; Budakoglu Burcin; Erekul Selim; Dural Koray; Sakinci Unal

2008-01-01

343

Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report.  

UK PubMed Central (United Kingdom)

Pleomorphic malignant fibrous histiocytoma (MFH), also known as undifferentiated high-grade pleomorphic sarcoma according to the latest World Health Organization classification, is a diagnosis of exclusion and extremely rare in adult scrotal/paratesticular region. Clinical presentation of scrotal/paratesticular pleomorphic MFH is usually a painless and gradual scrotal swelling. We report a case of scrotal MFH in a 63-year-old man who presented as Fournier gangrene after 10-month painful scrotal swelling and multiple procedures. The specimen of emergent debridement was submitted for pathologic and bacteriologic examination. Microscopically, the lesion had marked architectural and cytologic pleomorphism. The neoplastic cells were positive for vimentin, but negative for all lineage-specific markers. Fluorescence in-situ hybridization showed an aneuploid karyotype and negative results for lipomatous tumor abnormalities. Bacterial cultures of the specimen showed extensive growth of virulent polymicrobes. The diagnosis of scrotal/paratesticular pleomorphic MFH with concurrent Fournier gangrene was made. Thoracic computed tomography scan showed bilateral multiple pulmonary nodules. The patient died 1 month later.

Guo J; Zhou S; Rao NP; Pez GH

2010-10-01

344

Identification of APN/CD13 as the target antigen of FU3, a human monoclonal antibody that recognizes malignant fibrous histiocytoma.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma (MFH), a high-grade, undifferentiated sarcoma, is highly aggressive, resistant to radiochemotherapy and associated with poor prognosis. There are no specific immunohistochemical markers for its diagnosis. The MFH cell line SFT7913 served as and immunogen for the generation of the FU3 monoclonal antibody in our laboratory. FU3 reacted strongly with MFH cells and with perivascular mesenchymal cells. In this study, we demonstrated that the antigen recognized by FU3 was identical to aminopeptidase N (APN/CD13) using FU3 immunoaffinity chromatography and N-terminal amino acid sequencing. Frequent (80%) and high-grade (>50% of cells) expression of APN/CD13 was observed in MFH, although low-grade expression was seen in some other sarcomas. Moreover, small interfering RNA (siRNA) that specifically targets APN/CD13 significantly suppressed MFH cell invasion in vitro. The newly developed monoclonal antibody FU3 specifically recognizes CD13 on MFH cells. Decreased expression of CD13, mediated by siRNA-mediated knockdown, attenuated the invasive capacity of MFH cells. Thus, results indicate that APN/CD13 could be an important diagnostic biomarker and therapeutic target for MFH.

Aoki M; Nabeshima K; Hayashi H; Hamasaki M; Iwasaki H

2013-07-01

345

Mast Cells Inhibit CD8+ T Cell-Mediated Rejection of a Malignant Fibrous Histiocytoma-Like Tumor: Involvement of Fas-Fas Ligand Axis  

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Full Text Available Problem statement: Mast cells develop from bone marrow-derived progenitor cells and are distributed in the skin or mucosa where they play proinflammatory roles in the first line of defense. Since some tumors in humans and experimental animals exhibited infiltration of increased mast cells, we investigated the contribution of mast cells to the override of tumor rejection. Approach: MRL/N-1 cells are malignant fibrous histiocytoma-like cells established from the spleen of a Fas ligand (FasL)-deficient MRL/Mp-FasLgld/gld (MRL/gld) mouse and are implantable in Fas-deficient MRL/Mp-Faslpr/lpr (MRL/lpr) mice. MRL/N-1 cells were implanted in MRL/gld, MRL/lpr and MRL/+mice after antibody treatments or with mast cells or macrophages and the tumor growth was observed. Results: MRL/N-1 cells were rejected by Fas-intact syngeneic MRL/+ mice in CD8+ T cell-mediated manner. This rejection was inhibited by the co-implanted mast cells. MRL/N-1 cells transfected with FasL were rejected by MRL/+ and MRL/gld mice. Conclusion: Mast cells abrogate the rejection of MRL/N-1 tumor cells and that this tumor rejection is mediated by CD8+ T cells and dependent on host Fas-FasL axis.

Hiroshi Furukawa; Hiroshi Kitazawa; Izumi Kaneko; Koichi Koichi; Shigeto Tohma; Masato Nose; Masao Ono

2009-01-01

346

Identification of APN/CD13 as the target antigen of FU3, a human monoclonal antibody that recognizes malignant fibrous histiocytoma.  

Science.gov (United States)

Malignant fibrous histiocytoma (MFH), a high-grade, undifferentiated sarcoma, is highly aggressive, resistant to radiochemotherapy and associated with poor prognosis. There are no specific immunohistochemical markers for its diagnosis. The MFH cell line SFT7913 served as and immunogen for the generation of the FU3 monoclonal antibody in our laboratory. FU3 reacted strongly with MFH cells and with perivascular mesenchymal cells. In this study, we demonstrated that the antigen recognized by FU3 was identical to aminopeptidase N (APN/CD13) using FU3 immunoaffinity chromatography and N-terminal amino acid sequencing. Frequent (80%) and high-grade (>50% of cells) expression of APN/CD13 was observed in MFH, although low-grade expression was seen in some other sarcomas. Moreover, small interfering RNA (siRNA) that specifically targets APN/CD13 significantly suppressed MFH cell invasion in vitro. The newly developed monoclonal antibody FU3 specifically recognizes CD13 on MFH cells. Decreased expression of CD13, mediated by siRNA-mediated knockdown, attenuated the invasive capacity of MFH cells. Thus, results indicate that APN/CD13 could be an important diagnostic biomarker and therapeutic target for MFH. PMID:23677132

Aoki, Mikiko; Nabeshima, Kazuki; Hayashi, Hiroyuki; Hamasaki, Makoto; Iwasaki, Hiroshi

2013-05-16

347

Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches.  

UK PubMed Central (United Kingdom)

Malignant fibrous histiocytoma (MFH) and fibrosarcoma (FS) of bone are rare malignant tumours and contentious entities. Sixty seven cases labelled as bone MFH (57) and bone FS (10) were retrieved from five bone tumour referral centres and reviewed to determine whether recent advances allowed for reclassification and identification of histological subgroups with distinct clinical behaviour. A panel of immunostains was applied: smooth muscle actin, desmin, h-caldesmon, cytokeratin AE1-AE3, CD31, CD34, CD68, CD163, CD45, S100 and epithelial membrane antigen. Additional fluorescence in situ hybridisation and immunohistochemistry were performed whenever appropriate. All cases were reviewed by six bone and soft tissue pathologists and a consensus was reached. Follow-up for 43 patients (median 42 months, range 6-223 months) was available. Initial histological diagnosis was reformulated in 18 cases (26.8 %). Seven cases were reclassified as leiomyosarcoma, six as osteosarcoma, three as myxofibrosarcoma and one each as embryonal rhabdomyosarcoma and interdigitating dendritic cell sarcoma. One case showed a peculiar biphasic phenotype with epithelioid nests and myofibroblastic spindle cells. Among the remaining 48 cases, which met the WHO criteria for bone FS and bone MFH, we identified five subgroups. Seven cases were reclassified as undifferentiated pleomorphic sarcoma (UPS) and 11 as UPS with incomplete myogenic differentiation due to positivity for at least one myogenic marker. Six were reclassified as spindle cell sarcoma not otherwise specified. Among the remaining 24 cases, we identified a further two recurrent morphologic patterns: eight cases demonstrated a myoepithelioma-like phenotype and 16 cases a myofibroblastic phenotype. One of the myoepithelioma-like cases harboured a EWSR1-NFATC2 fusion. It appears that bone MFH and bone FS represent at best exclusion diagnoses.

Romeo S; Bovée JV; Kroon HM; Tirabosco R; Natali C; Zanatta L; Sciot R; Mertens F; Athanasou N; Alberghini M; Szuhai K; Hogendoorn PC; Dei Tos AP

2012-11-01

348

Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches.  

Science.gov (United States)

Malignant fibrous histiocytoma (MFH) and fibrosarcoma (FS) of bone are rare malignant tumours and contentious entities. Sixty seven cases labelled as bone MFH (57) and bone FS (10) were retrieved from five bone tumour referral centres and reviewed to determine whether recent advances allowed for reclassification and identification of histological subgroups with distinct clinical behaviour. A panel of immunostains was applied: smooth muscle actin, desmin, h-caldesmon, cytokeratin AE1-AE3, CD31, CD34, CD68, CD163, CD45, S100 and epithelial membrane antigen. Additional fluorescence in situ hybridisation and immunohistochemistry were performed whenever appropriate. All cases were reviewed by six bone and soft tissue pathologists and a consensus was reached. Follow-up for 43 patients (median 42 months, range 6-223 months) was available. Initial histological diagnosis was reformulated in 18 cases (26.8 %). Seven cases were reclassified as leiomyosarcoma, six as osteosarcoma, three as myxofibrosarcoma and one each as embryonal rhabdomyosarcoma and interdigitating dendritic cell sarcoma. One case showed a peculiar biphasic phenotype with epithelioid nests and myofibroblastic spindle cells. Among the remaining 48 cases, which met the WHO criteria for bone FS and bone MFH, we identified five subgroups. Seven cases were reclassified as undifferentiated pleomorphic sarcoma (UPS) and 11 as UPS with incomplete myogenic differentiation due to positivity for at least one myogenic marker. Six were reclassified as spindle cell sarcoma not otherwise specified. Among the remaining 24 cases, we identified a further two recurrent morphologic patterns: eight cases demonstrated a myoepithelioma-like phenotype and 16 cases a myofibroblastic phenotype. One of the myoepithelioma-like cases harboured a EWSR1-NFATC2 fusion. It appears that bone MFH and bone FS represent at best exclusion diagnoses. PMID:23001328

Romeo, Salvatore; Bovée, Judith V M G; Kroon, Herman M; Tirabosco, Roberto; Natali, Cristina; Zanatta, Lucia; Sciot, Raf; Mertens, Fredrik; Athanasou, Nick; Alberghini, Marco; Szuhai, Karoly; Hogendoorn, Pancras C W; Dei Tos, Angelo Paolo

2012-09-22

349

Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization  

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Full Text Available Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH) is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluorescence in situ hybridization (M-FISH), Urovysion™ FISH, and comparative genomic hybridization (CGH) for the characterization of chromosomal aberrations. FU-MFH-2 cells were spindle or polygonal in shape with oval nuclei, and were successfully maintained in vitro for over 80 passages. The histological features of heterotransplanted tumors in severe combined immunodeficiency mice were essentially the same as those of the original tumor. Cytogenetic and M-FISH analyses displayed a hypotriploid karyotype with numerous structural aberrations. Urovysion™ FISH revealed a homozygous deletion of the p16INK4A locus on chromosome band 9p21. CGH analysis showed a high-level amplification of 9q31-q34, gains of 1p12-p34.3, 2p21, 2q11.2-q21, 3p, 4p, 6q22-qter, 8p11.2, 8q11.2-q21.1, 9q21-qter, 11q13, 12q24, 15q21-qter, 16p13, 17, 20, and X, and losses of 1q43-qter, 4q32-qter, 5q14-q23, 7q32-qter, 8p21-pter, 8q23, 9p21-pter, 10p11.2-p13, and 10q11.2-q22. Conclusion The FU-MFH-2 cell line will be a particularly useful model for studying molecular pathogenesis of human pleomorphic MFH.

Nishio Jun; Iwasaki Hiroshi; Nabeshima Kazuki; Ishiguro Masako; Isayama Teruto; Naito Masatoshi

2010-01-01

350

Benign fibrous histiocytoma of the retroperitoneum. Benignes Histiozytom des Retroperitoneums  

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A case of benign fibrous histiocytoma of the retroperitoneum accidentally found on ultrasound in a fifty-six year old woman is reported. Diagnosis and differential diagnosis in special consideration or radiological methods are discussed. (orig.)

Feix, I. (Abteilung fuer Radiologie und Nuklearmedizin, Krankenhaus am Urban, Berlin (Germany))

1993-05-01

351

Metastatic angiomatoid fibrous histiocytoma of the scalp, with EWSR1-CREB1 gene fusions in primary tumor and nodal metastasis.  

UK PubMed Central (United Kingdom)

Angiomatoid fibrous histiocytoma is a rare soft tissue tumor of intermediate biologic potential, predominantly arising in superficial extremities of children and young adults. Less than 5% metastasize. We describe a case of angiomatoid fibrous histiocytoma in the scalp of an 8-year-old boy, which metastasized to a postauricular lymph node 3 years after primary tumor excision. Histologically, primary and metastasis comprised nodules of bland ovoid cells, with primary additionally showing hemorrhagic cavities, fibrous capsule, and lymphoplasmacytic inflammation. Both strongly expressed desmin, with focal epithelial membrane antigen. Reverse transcription-polymerase chain reaction showed EWSR1-CREB1 fusion transcripts in both primary and metastasis. This is, to our knowledge, the first description of genetically proven metastatic angiomatoid fibrous histiocytoma. Angiomatoid fibrous histiocytoma can mimic both benign and malignant lesions, and although most behave indolently, it is important to recognize their metastatic potential.

Thway K; Stefanaki K; Papadakis V; Fisher C

2013-02-01

352

Metastatic angiomatoid fibrous histiocytoma of the scalp, with EWSR1-CREB1 gene fusions in primary tumor and nodal metastasis.  

Science.gov (United States)

Angiomatoid fibrous histiocytoma is a rare soft tissue tumor of intermediate biologic potential, predominantly arising in superficial extremities of children and young adults. Less than 5% metastasize. We describe a case of angiomatoid fibrous histiocytoma in the scalp of an 8-year-old boy, which metastasized to a postauricular lymph node 3 years after primary tumor excision. Histologically, primary and metastasis comprised nodules of bland ovoid cells, with primary additionally showing hemorrhagic cavities, fibrous capsule, and lymphoplasmacytic inflammation. Both strongly expressed desmin, with focal epithelial membrane antigen. Reverse transcription-polymerase chain reaction showed EWSR1-CREB1 fusion transcripts in both primary and metastasis. This is, to our knowledge, the first description of genetically proven metastatic angiomatoid fibrous histiocytoma. Angiomatoid fibrous histiocytoma can mimic both benign and malignant lesions, and although most behave indolently, it is important to recognize their metastatic potential. PMID:23199525

Thway, Khin; Stefanaki, Kalliopi; Papadakis, Vassilios; Fisher, Cyril

2012-11-27

353

Angiomatoid fibrous histiocytoma: a case report and review of the literature.  

UK PubMed Central (United Kingdom)

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor most commonly occurring in children, adolescents, and young adults. Clinically and radiographically the lesion is easily confused with a hematoma, soft tissue hemangioma, or malignant fibrous histiocytoma. While the lesion is rare, due to the potential for local recurrence and metastasis, it is imperative to consider this lesion in the differential diagnosis of a soft tissue mass in a child or adolescent. Here, we present the clinical, radiologic, and pathologic findings of a case of AFH.

Bauer A; Jackson B; Marner E; Gilbertson-Dahdal D

2012-11-01

354

[Cellular fibrous histiocytoma: a clinicopathologic analysis of 27 cases].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To study the clinicopathologic characteristics of cellular fibrous histiocytoma (CFH) with emphasis on diagnosis and differential diagnosis. METHODS: Clinical and pathologic features were reviewed in 27 cases of CFH (encountered during the period from 2008 to 2012) along with outcome analysis. Immunophenotyping was performed with EnVision method. RESULTS: The patients included 13 males and 14 females. The age at presentation ranged from 15 to 61 years (mean, 34 years; median, 32 years). The tumor occurred in the extremities (n = 14), head and neck (n = 7), and trunk (n = 6). Histologically, the tumors were located in the dermis. Some cases showed wedge like extension into the subcutaneous adipose tissue. On high power, they consisted of dense fibroblasts and myofibroblasts. Other cell components such as psammoma-like histiocytes, hemosiderin-containing macrophages or touton-type giant cells were rare. The spindled tumor cells were arranged mostly in intersecting fascicles. Focal storiform architecture was not uncommon. In addition, a few cases showed prominent hemangiopericytoma-like pattern. There was no prominent cellular atypia but increased mitotic figures were not difficult to find. Two cases exhibited necrosis. By immunohistochemistry, the tumor cells showed variable expression of alpha smooth muscle actin. CD34 positive cells were present in some cases, but were distributed mostly in the periphery or bottom of the lesions. They were all negative for desmin, h-caldesmon, S-100 protein and cytokeratin. Follow-up in 19 cases revealed local recurrences in 5 cases and bilateral pulmonary metastases in 1 case after repeated recurrences. CONCLUSIONS: CFH is a cellular form of benign fibrous histiocytoma which has a risk for local recurrence after incomplete excision. Distant metastasis can occur in rare examples. However, there were no morphological parameters predicting the risk of recurrence or metastasis. Increased awareness of the clinocopathological features and immunophenotypes of CFH is helpful in avoiding misdiagnosing the disease as malignant tumors, especially dermatofibrosarcoma protuberans.

Zhong YP; Wang J

2013-03-01

355

Benign fibrous histiocytoma involving the ends of long bone  

International Nuclear Information System (INIS)

Five bone tumors, previously labelled as benign fibrous histiocytoma in our Bone Tumor registry were reviewed. All the cases were reexamined clinically, radiologically, and histologically. Ages of the patients ranged from 17 to 68 years and all tumours involved the epiphysis or epiphysiometaphysis of long tubular bones. A diagnosis of giant cell tumor was suggested from initial radiographs in all cases. Three cases proved to be giant cell tumors of bone after thorough examination of previous histological specimens. In the diagnosis of benign fibrous histiocytoma of epiphyseal origin in adults, the possibility of giant cell tumor of bone should always be kept in mind, and painstaking histological examination is required. (orig.)

1990-01-01

356

Benign fibrous histiocytoma involving the ends of long bone  

Energy Technology Data Exchange (ETDEWEB)

Five bone tumors, previously labelled as benign fibrous histiocytoma in our Bone Tumor registry were reviewed. All the cases were reexamined clinically, radiologically, and histologically. Ages of the patients ranged from 17 to 68 years and all tumours involved the epiphysis or epiphysiometaphysis of long tubular bones. A diagnosis of giant cell tumor was suggested from initial radiographs in all cases. Three cases proved to be giant cell tumors of bone after thorough examination of previous histological specimens. In the diagnosis of benign fibrous histiocytoma of epiphyseal origin in adults, the possibility of giant cell tumor of bone should always be kept in mind, and painstaking histological examination is required. (orig.).

Matsuno, Takeo (Hokkaido Univ., Sapporo (Japan). Dept. of Orthopedics)

1990-11-01

357

Case report 359: Gigantic benign fibrous histiocytoma (nonossifying fibroma)  

International Nuclear Information System (INIS)

In summary, a fascinating case is presented of an enormous 'blow-out' lesion in the left half of the mandible in a 17-year-old boy. The histological diagnosis was benign fibrous histiocytoma or non-ossifying fibroma. An extensive differential diagnosis was presented by the authors and although benign fibrous histiocytoma was their final diagnosis, they could not exclude an example of the rarely encountered entity called the Jaffe-Campanacci syndrome. This syndrome consists of multiple non-ossifying fibromas of the mandible, cafe-au-lait spots, various endocrine disorders, mental retardation, occular anomalies and cardiovascular malformations. (orig./SHA)

1986-01-01

358

Case report 359: Gigantic benign fibrous histiocytoma (nonossifying fibroma)  

Energy Technology Data Exchange (ETDEWEB)

In summary, a fascinating case is presented of an enormous 'blow-out' lesion in the left half of the mandible in a 17-year-old boy. The histological diagnosis was benign fibrous histiocytoma or non-ossifying fibroma. An extensive differential diagnosis was presented by the authors and although benign fibrous histiocytoma was their final diagnosis, they could not exclude an example of the rarely encountered entity called the Jaffe-Campanacci syndrome. This syndrome consists of multiple non-ossifying fibromas of the mandible, cafe-au-lait spots, various endocrine disorders, mental retardation, occular anomalies and cardiovascular malformations. (orig./SHA).

Remagen, W.; Nidecker, A.; Prein, J.

1986-03-01

359

Angiomatoid fibrous histiocytoma in a 25-year-old male  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Angiomatoid fibrous histiocytoma (AFH) is a rare disease that is often misdiagnosed initially. Patients can present with a clinical picture concerning for other diseases, and pathologic review is not always revealing. Molecular diagnostics are increasingly being utilized to detect gene fusions chara...

Mansfield, Aaron; Larson, Brenda; Stafford, Scott L; Shives, Thomas C; Haddock, Michael G; Dingli, David

360

[Atypical fibrous histiocytoma: a clinicopathologic analysis of 24 cases].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To study the clinicopathologic characteristics of atypical fibrous histiocytoma (AFH), with emphasis on differential diagnosis. METHODS: The clinical and pathologic features were reviewed in 24 cases of AFH (from 2007 to 2012). The follow-up data were analyzed. Immunohistochemical study using EnVision method was carried out. RESULTS: There were 10 males and 14 females with age at presentation ranging from 8 to 67 years (mean = 41 years and median = 39 years). The tumor occurred in the extremities (number = 14), trunk (number = 8) or head and neck region (number = 2). Apart from one case, all were located in the dermis. The clinical appearance was similar to those of classic fibrous histiocytoma. Histologically, the tumor was characterized by various number of hyperchromatic bizarre cells scattered in the background. Mitotic figures including atypical ones were noted, especially in the more cellular areas. Immunohistochemical study showed that the tumor cells expressed vimentin. Focal positivity for alpha-smooth muscle actin was demonstrated in some cases. Follow-up information was available in 14 cases. Three of them suffered local recurrence. None of these cases had distant metastasis. CONCLUSIONS: Atypical fibrous histiocytoma represents a pleomorphic variant of fibrous histiocytoma. Although the tumor exhibits worrisome features, it usually pursuits a relatively benign course. Nevertheless, rare cases may recur, especially after incomplete excision. AFH is sometimes mistaken as atypical fibroxanthoma. A distinction between the two entities is warranted as they represent two different entities.

Weng WW; Yang J; Wang J

2013-05-01

 
 
 
 
361

Deep benign fibrous histiocytoma: computed tomography and histology findings  

International Nuclear Information System (INIS)

We present the computed tomography images of an 83-year-old male patient with a deep benign fibrous histiocytoma at the lateral aspect of the left leg. Computed tomography images showed a well-defined mass with marked peripheral enhancement by iodinated contrast medium. Only few reports of this rare soft tissue tumor can be found in the literature. (author)

2005-01-01

362

Benign fibrous histiocytoma of bone: a case report.  

UK PubMed Central (United Kingdom)

Benign fibrous histiocytoma (BFH) occurs commonly in soft tissues with very few cases of BFH of bone on record. We report a case of BFH of tibia in fifty year old male who presented with supracondylar fracture femur due to trivial fall and a brief review of literature.

Bhople KS; Kulkarni PV; Arora N; Satarkar R

2006-10-01

363

Benign fibrous histiocytoma of bone: a case report.  

Science.gov (United States)

Benign fibrous histiocytoma (BFH) occurs commonly in soft tissues with very few cases of BFH of bone on record. We report a case of BFH of tibia in fifty year old male who presented with supracondylar fracture femur due to trivial fall and a brief review of literature. PMID:17183867

Bhople, K S; Kulkarni, P V; Arora, Neeraj; Satarkar, Rahul

2006-10-01

364

Angiomatoid fibrous histiocytoma with cystic structures of sweat duct origin.  

Science.gov (United States)

Angiomatoid fibrous histiocytoma is an unusual soft tissue tumor, mostly arising in the subcutaneous fibro-adipose tissue of children and young adults and measuring a few centimeters in greatest dimension. Reported herein is a unique case of angiomatoid fibrous histiocytoma containing epithelium-lined cystic structures. This large tumor (12 cm) was located in the subcutaneous tissue of the left leg of a 28-year-old woman. The cystic structures were variably sized and were lined by a double cell layer with areas of squamous metaplasia. Their overall histological features suggested a sweat duct origin. Immunohistochemical stains confirmed such origin, demonstrating an inner epithelial and an outer myoepithelial (smooth muscle actin and cytokeratin 17 positive) cell layer. The present case is illustrative of a mechanism of sweat duct dilatation that may occur during the growth of neoplasms involving the dermis and subcutis, resulting in formation of tumors with unusual histological features. PMID:17610476

Koletsa, Triantafyllia; Hytiroglou, Prodromos; Semoglou, Christos; Drevelegas, Antonios; Karkavelas, Georgios

2007-08-01

365

Angiomatoid fibrous histiocytoma with cystic structures of sweat duct origin.  

UK PubMed Central (United Kingdom)

Angiomatoid fibrous histiocytoma is an unusual soft tissue tumor, mostly arising in the subcutaneous fibro-adipose tissue of children and young adults and measuring a few centimeters in greatest dimension. Reported herein is a unique case of angiomatoid fibrous histiocytoma containing epithelium-lined cystic structures. This large tumor (12 cm) was located in the subcutaneous tissue of the left leg of a 28-year-old woman. The cystic structures were variably sized and were lined by a double cell layer with areas of squamous metaplasia. Their overall histological features suggested a sweat duct origin. Immunohistochemical stains confirmed such origin, demonstrating an inner epithelial and an outer myoepithelial (smooth muscle actin and cytokeratin 17 positive) cell layer. The present case is illustrative of a mechanism of sweat duct dilatation that may occur during the growth of neoplasms involving the dermis and subcutis, resulting in formation of tumors with unusual histological features.

Koletsa T; Hytiroglou P; Semoglou C; Drevelegas A; Karkavelas G

2007-08-01

366

Another cystic lesion in the calcaneus: benign fibrous histiocytoma of bone.  

UK PubMed Central (United Kingdom)

Benign fibrous histiocytoma is a rare benign primary skeletal tumor that occurs frequently in the long bones and the pelvis. The calcaneus is an unusual location for benign fibrous histiocytoma. We did not identify any case of benign fibrous histiocytoma involving the calcaneus in the relevant literature. We describe a 22-year-old male patient with benign fibrous histiocytoma involving the calcaneus treated with curettage and bone grafting. At the final follow-up visit, 1 year after surgery, the patient was free of pain and walking unaided. We discuss the differential diagnosis of cystic lesions of the calcaneus.

Keskinbora M; Köse O; Karslioglu Y; Demiralp B; Basbozkurt M

2013-03-01

367

Another cystic lesion in the calcaneus: benign fibrous histiocytoma of bone.  

Science.gov (United States)

Benign fibrous histiocytoma is a rare benign primary skeletal tumor that occurs frequently in the long bones and the pelvis. The calcaneus is an unusual location for benign fibrous histiocytoma. We did not identify any case of benign fibrous histiocytoma involving the calcaneus in the relevant literature. We describe a 22-year-old male patient with benign fibrous histiocytoma involving the calcaneus treated with curettage and bone grafting. At the final follow-up visit, 1 year after surgery, the patient was free of pain and walking unaided. We discuss the differential diagnosis of cystic lesions of the calcaneus. PMID:23536505

Keskinbora, Mert; Köse, Ozkan; Karslioglu, Yildirim; Demiralp, Bahtiyar; Basbozkurt, Mustafa

368

Atypical fibrous histiocytoma of the thoracic spine. Case report.  

Science.gov (United States)

A 14-year-old boy presented with mid-thoracic pain, leg weakness, and bladder dysfunction. Plain x-ray films and bone scan were normal whereas myelography demonstrated an extradural mass extending from T-2 to T-5. Exploration revealed a large tumor adherent to dura and bone. Pathological verification of an atypical fibrous histiocytoma prompted the report of this rare tumor of the vertebral column. PMID:224154

Guarnaschelli, J J; Wehry, S M; Serratoni, F T; Dzenitis, A J

1979-09-01

369

Atypical fibrous histiocytoma of the thoracic spine. Case report.  

UK PubMed Central (United Kingdom)

A 14-year-old boy presented with mid-thoracic pain, leg weakness, and bladder dysfunction. Plain x-ray films and bone scan were normal whereas myelography demonstrated an extradural mass extending from T-2 to T-5. Exploration revealed a large tumor adherent to dura and bone. Pathological verification of an atypical fibrous histiocytoma prompted the report of this rare tumor of the vertebral column.

Guarnaschelli JJ; Wehry SM; Serratoni FT; Dzenitis AJ

1979-09-01

370

An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy.  

UK PubMed Central (United Kingdom)

A 13-year-old boy presented to us for the evaluation of a slowly growing mass over the left preauricular region. Physical examination showed a nodular swelling, firm on palpation. The patient had no lymphadenopathy. The findings of magnetic resonance imaging (MRI) and vascular MRI led us to suspect a vascular growth. An incisional biopsy was performed and revealed an angiomatoid fibrous histiocytoma (AFH). Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of the soft tissue with fibrohistiocytic and vascular differentiation that shows an intermediate malignancy grade, mainly occurs in patients younger than 20 years of age, and is usually localized on the extremities. Angiomatoid fibrous histiocytoma is considered to be a tumor of intermediate malignancy because of its less aggressive course in contrast to conventional malignant fibrous histiocytoma (MFH). Our case of AFH is peculiar because of its localization in the pre auricular region and because it appeared in a young patient. Surgical excision with maxillo-facial, chest-abdomen, and neck CT and prolonged follow-up is recommended because rare cases of metastasizing AFH have been reported.

Patrizi A; Tabanelli M; Filippi G; Gurioli C; Nozza P; Savoia F; Dalmonte P; Misciali C

2010-01-01

371

Spontaneous malignant transformation in craniomaxillofacial fibrous dysplasia.  

UK PubMed Central (United Kingdom)

Spontaneous malignant transformation in craniomaxillofacial fibrous dysplasia (FD) is extremely rare and its clinicopathological characteristics remain largely unknown. Here, we aimed to characterize the epidemiology and clinicopathological features of malignancies arising from preexisting FD by presenting data from a Chinese tertiary referral hospital and review of English and Chinese literatures. The craniomaxillofacial disease registry of Shanghai Ninth People's Hospital was searched and reviewed to collect relevant information for patients diagnosed as malignant transformation in craniomaxillofacial FD between January 1993 and December 2010. An English and Chinese literature review was conducted to retrieve pertinent cases published in the past 2 decades with preset inclusion criteria. All included cases were further analyzed with regard to associated clinical and pathological variables. Three cases with osteosarcoma arising from previous craniomaxillofacial FD were found at our institution and 35 other cases were identified by literature review. These uncommon entities usually occurred in adults with a mean age of 39.8 years and equal gender preponderance. Maxilla remained the most common sites for malignancies followed by mandible and zygoma. Most malignancies were diagnosed as osteosarcoma followed by fibrosarcoma, chondrosarcoma, and malignant fibrous histiocytoma. Radical resection alone or with postoperative radiotherapy/chemotherapy remains the main treatment strategy with unfavorable prognosis due to local recurrence and distant metastasis. Taken together, our findings might for the first time provide the comprehensive information regarding the epidemiology, clinicopathological features, treatment, and prognosis of malignancies in craniomaxillofacial FD. Further investigations are warranted to improve early diagnosis and proper treatment for these uncommon entities.

Cheng J; Yu H; Wang D; Ye J; Jiang H; Wu Y; Shen G

2013-01-01

372

Spontaneous malignant transformation in craniomaxillofacial fibrous dysplasia.  

Science.gov (United States)

Spontaneous malignant transformation in craniomaxillofacial fibrous dysplasia (FD) is extremely rare and its clinicopathological characteristics remain largely unknown. Here, we aimed to characterize the epidemiology and clinicopathological features of malignancies arising from preexisting FD by presenting data from a Chinese tertiary referral hospital and review of English and Chinese literatures. The craniomaxillofacial disease registry of Shanghai Ninth People's Hospital was searched and reviewed to collect relevant information for patients diagnosed as malignant transformation in craniomaxillofacial FD between January 1993 and December 2010. An English and Chinese literature review was conducted to retrieve pertinent cases published in the past 2 decades with preset inclusion criteria. All included cases were further analyzed with regard to associated clinical and pathological variables. Three cases with osteosarcoma arising from previous craniomaxillofacial FD were found at our institution and 35 other cases were identified by literature review. These uncommon entities usually occurred in adults with a mean age of 39.8 years and equal gender preponderance. Maxilla remained the most common sites for malignancies followed by mandible and zygoma. Most malignancies were diagnosed as osteosarcoma followed by fibrosarcoma, chondrosarcoma, and malignant fibrous histiocytoma. Radical resection alone or with postoperative radiotherapy/chemotherapy remains the main treatment strategy with unfavorable prognosis due to local recurrence and distant metastasis. Taken together, our findings might for the first time provide the comprehensive information regarding the epidemiology, clinicopathological features, treatment, and prognosis of malignancies in craniomaxillofacial FD. Further investigations are warranted to improve early diagnosis and proper treatment for these uncommon entities. PMID:23348272

Cheng, Jie; Yu, Hongbo; Wang, Dongmiao; Ye, Jinhai; Jiang, Hongbin; Wu, Yunong; Shen, Guofang

2013-01-01

373

Photoletter to the editor: Fibrous histiocytoma developing at the site of tuberculin skin test.  

UK PubMed Central (United Kingdom)

Benign fibrous histiocytomas of the skin sometimes extend into the deeper dermis with higher cellularity and show more aggressive clinical courses in comparison with typical dermatofibromas. They may occur either as a true neoplasm or in a reactive process. We describe a case of fibrous histiocytoma which was triggered by tuberculin skin test.

Nomura E; Yamamoto T

2012-12-01

374

Photoletter to the editor: Fibrous histiocytoma developing at the site of tuberculin skin test.  

Science.gov (United States)

Benign fibrous histiocytomas of the skin sometimes extend into the deeper dermis with higher cellularity and show more aggressive clinical courses in comparison with typical dermatofibromas. They may occur either as a true neoplasm or in a reactive process. We describe a case of fibrous histiocytoma which was triggered by tuberculin skin test. PMID:23329995

Nomura, Erika; Yamamoto, Toshiyuki

2012-12-31

375

Benign fibrous histiocytoma of larynx: A rare cause of acute airway obstruction  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fibrous histiocytoma of larynx is a rare entity. We herein present a 35-year-old femaleof benign fibrous histiocytoma oflarynx with severe airway obstruction that requiring urgent endotracheal intubation followed by tracheostomy. We also report the good long-term survival of this case after such a c...

Gupta, Shiv Sagar; Singhal, Sanjay

376

Benign fibrous histiocytoma of larynx: A rare cause of acute airway obstruction  

Directory of Open Access Journals (Sweden)

Full Text Available Fibrous histiocytoma of larynx is a rare entity. We herein present a 35-year-old femaleof benign fibrous histiocytoma of larynx with severe airway obstruction that requiring urgent endotracheal intubation followed by tracheostomy. We also report the good long-term survival of this case after such a critical condition.

Gupta Shiv; Singhal Sanjay

2010-01-01

377

Benign fibrous histiocytoma of larynx: A rare cause of acute airway obstruction  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fibrous histiocytoma of larynx is a rare entity. We herein present a 35-year-old femaleof benign fibrous histiocytoma of larynx with severe airway obstruction that requiring urgent endotracheal intubation followed by tracheostomy. We also report the good long-term survival of this case after such a ...

Gupta Shiv; Singhal Sanjay

378

Subcutaneous benign fibrous histiocytoma of the cheek. Case report and review of the literature  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fibrous histiocytoma is a benign tumour composed of a mixture of fibroblastic and histiocytic cells. Based on the location of this tumour, fibrous histiocytoma are usually divided into cutaneous types and those involving deep tissues. These lesions most often arise on the skin, but may rarely occur ...

Skoulakis, CE; Papadakis, CE; Datseris, GE; Drivas, EI; Kyrmizakis, DE; Bizakis, JG

379

An unusual soft tissue tumor with features of angiomatoid malignant fibrous histiocytoma composed of bimodal CD34 and factor XIIIa positive dendritic cell subsets. CD34 and factor XIIIa in angiomatoid MFH.  

UK PubMed Central (United Kingdom)

CD34 and factor XIIIa (FXIIIa) antibodies delineate subsets of embryonic dendritic stromal stem cells that persist in adult mesenchyme. CD34 stains interstitial and adventitial dendritic cells that may function as multipotential precursor cells. FXIIIa+ dendrophages are tissue histiocytes active in tissue repair. Angiomatoid malignant fibrous histiocytoma (AMFH) is an enigmatic fibrohistiocytic tumor with limited vascular features. We examined an unusual soft tissue tumor from the nasolabial subcutis of a 57 year old man that showed histologic features of AMFH. Most of the tumor cells expressed CD34. 10-30% of the tumor cells were FXIIIa+ dendrophages. Sinusoidal areas were largely composed of FXIIIa+ cells that also expressed HLA-DR and CD68 suggesting macrophage differentiation. CD31 and Factor VIII antigen highlighted capillaries and single cells among the CD34+ tumor cells. The vessels had actin+ myopericytes and there were single actin+ tumor cells. Electron microscopy showed primitive dendritic cells and fewer histiocyte-like cells. The Ki 67 index was 15% including both FXIIIa+ and CD34+ cells. The patient is disease free three years after wide excision. We conclude that this AMFH-like neoplasm is a fibrohistiocytic tumor in which CD34+ fibroblast-like precursors and FXIIIa+ tissue dendrophages combine to build both sinusoidal tissue with endothelial and macrophage elements as well as capillary vascular tissue that is invested with myopericytes. Study of additional AMFH lesions from this standpoint is desirable.

Silverman JS; Lomvardias S

1997-01-01

380

An unusual soft tissue tumor with features of angiomatoid malignant fibrous histiocytoma composed of bimodal CD34 and factor XIIIa positive dendritic cell subsets. CD34 and factor XIIIa in angiomatoid MFH.  

Science.gov (United States)

CD34 and factor XIIIa (FXIIIa) antibodies delineate subsets of embryonic dendritic stromal stem cells that persist in adult mesenchyme. CD34 stains interstitial and adventitial dendritic cells that may function as multipotential precursor cells. FXIIIa+ dendrophages are tissue histiocytes active in tissue repair. Angiomatoid malignant fibrous histiocytoma (AMFH) is an enigmatic fibrohistiocytic tumor with limited vascular features. We examined an unusual soft tissue tumor from the nasolabial subcutis of a 57 year old man that showed histologic features of AMFH. Most of the tumor cells expressed CD34. 10-30% of the tumor cells were FXIIIa+ dendrophages. Sinusoidal areas were largely composed of FXIIIa+ cells that also expressed HLA-DR and CD68 suggesting macrophage differentiation. CD31 and Factor VIII antigen highlighted capillaries and single cells among the CD34+ tumor cells. The vessels had actin+ myopericytes and there were single actin+ tumor cells. Electron microscopy showed primitive dendritic cells and fewer histiocyte-like cells. The Ki 67 index was 15% including both FXIIIa+ and CD34+ cells. The patient is disease free three years after wide excision. We conclude that this AMFH-like neoplasm is a fibrohistiocytic tumor in which CD34+ fibroblast-like precursors and FXIIIa+ tissue dendrophages combine to build both sinusoidal tissue with endothelial and macrophage elements as well as capillary vascular tissue that is invested with myopericytes. Study of additional AMFH lesions from this standpoint is desirable. PMID:9112273

Silverman, J S; Lomvardias, S

1997-01-01

 
 
 
 
381

Angiomatoid fibrous histiocytoma in a 25-year-old male  

Directory of Open Access Journals (Sweden)

Full Text Available Angiomatoid fibrous histiocytoma (AFH) is a rare disease that is often misdiagnosed initially. Patients can present with a clinical picture concerning for other diseases, and pathologic review is not always revealing. Molecular diagnostics are increasingly being utilized to detect gene fusions characteristic for AFH. Surgery remains the mainstay of management, and can effectively control local recurrences and metastases. Herein we describe a case report of a 25-year-old gentleman whose presentation was concerning for lymphoma. Subsequently we review of the relevant literature.

Aaron Scott Mansfield; Brenda Larson; Scott L. Stafford; Thomas C. Shives; Michael G. Haddock; David Dingli

2010-01-01

382

Retroperitoneal angiomatoid fibrous histiocytoma: A case report and review of the literature.  

UK PubMed Central (United Kingdom)

Angiomatoid fibrous histiocytoma (AFH) is a rare, low-grade malignant potential soft tissue tumor which occurs most commonly in children and young adults. Only a few case reports have been described that typically occur in the extremities of the deep dermis and subcutaneous tissue, followed by the trunk, as well as the head and neck. A case report of retroperitoneal AFH is described. This presentation for patients with AFH has not yet been reported. AFH may occur in the retroperitoneum, in the future patients with retroperitoneal tumor should be considered the posibility of having AFH.

Xiang L; Zhou J; Gu W; Yang B

2013-06-01

383

Presentación de un caso de sarcoma maligno laríngeo, tratado mediante laringotomía transversa y revisión de la literatura Transversal laryngotomy. Oncologic and functional results in laryngeal sarcoma.(Malignant fibrous histiocytoma). Case report and literature review.  

Directory of Open Access Journals (Sweden)

Full Text Available Los sarcomas de la laringe son neoplasias que constituyen menos del 1% de los tumores malignos, y su tratamiento habitual es quirúrgico que incluye la laringectomía parcial o total y la cordectomía endoscópica con láser, con recurrencias de hasta 20%. Debido a experiencia positiva en nuestro país con la laringotomía transversa en casos de aritenoidectomía para tratar parálisis bilateral de las cuerdas vocales como consecuencia de tiroidectomía total, el propósito de este reporte fue el de informar el resultado obtenido con esta técnica de laringotomía transversa a un caso raro de sarcoma glótico en un médico de 47 años que tenía cuatro meses de disfonía moderada sin disnea, disfagia ni estridor y sin historia de radioterapia o quimioterapia previas. La lesión fue evaluada por endoscopia y tomografía laríngea que mostraron un tumor del lado derecho de la glotis de 3 a 4 cm de tamaño no ulcerado. El informe patológico fue de un fibrohistiocitoma maligno. Cinco años después el paciente está bien y sin evidencia de enfermedad.Sarcomas of the larynx are rare neoplasmas that consitute less than 1% of laryngeal malignancies, and their usual treatment is surgery including partial and total laryngectomy and endoscopic laser cordotomy with reported 20% recurrence. Due to previous positive experience from transversal laryngotomy in patients who underwent aritenoidectomy to treat bilateral cord paralysis after total thyroidectomy, the purpose of this work was to report on the surgical treatment of this rare case with such technique. Thus, a 47 year-old physician who complained of hoarseness for four months without dyspnea, stridor, or dysphagia and with no history of irradiation or chemotherapy was operated after both endoscopic and tomographic studies showed a 3 to 4 cm glotic tumor in its right side, with no ulceration. The pathology proved to be malignant fibrous histiocytoma. Five years after surgery the patient is alive with no evidence of disease.

Ángel F Pérez; Rafael Muñoz; Josefa Morales; Ennio Fereira; José Colina Chourio

2008-01-01

384

Presentación de un caso de sarcoma maligno laríngeo, tratado mediante laringotomía transversa y revisión de la literatura/ Transversal laryngotomy. Oncologic and functional results in laryngeal sarcoma.(Malignant fibrous histiocytoma). Case report and literature review.  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Los sarcomas de la laringe son neoplasias que constituyen menos del 1% de los tumores malignos, y su tratamiento habitual es quirúrgico que incluye la laringectomía parcial o total y la cordectomía endoscópica con láser, con recurrencias de hasta 20%. Debido a experiencia positiva en nuestro país con la laringotomía transversa en casos de aritenoidectomía para tratar parálisis bilateral de las cuerdas vocales como consecuencia de tiroidectomía total, el propósi (more) to de este reporte fue el de informar el resultado obtenido con esta técnica de laringotomía transversa a un caso raro de sarcoma glótico en un médico de 47 años que tenía cuatro meses de disfonía moderada sin disnea, disfagia ni estridor y sin historia de radioterapia o quimioterapia previas. La lesión fue evaluada por endoscopia y tomografía laríngea que mostraron un tumor del lado derecho de la glotis de 3 a 4 cm de tamaño no ulcerado. El informe patológico fue de un fibrohistiocitoma maligno. Cinco años después el paciente está bien y sin evidencia de enfermedad. Abstract in english Sarcomas of the larynx are rare neoplasmas that consitute less than 1% of laryngeal malignancies, and their usual treatment is surgery including partial and total laryngectomy and endoscopic laser cordotomy with reported 20% recurrence. Due to previous positive experience from transversal laryngotomy in patients who underwent aritenoidectomy to treat bilateral cord paralysis after total thyroidectomy, the purpose of this work was to report on the surgical treatment of thi (more) s rare case with such technique. Thus, a 47 year-old physician who complained of hoarseness for four months without dyspnea, stridor, or dysphagia and with no history of irradiation or chemotherapy was operated after both endoscopic and tomographic studies showed a 3 to 4 cm glotic tumor in its right side, with no ulceration. The pathology proved to be malignant fibrous histiocytoma. Five years after surgery the patient is alive with no evidence of disease.

Pérez, Ángel F; Muñoz, Rafael; Morales, Josefa; Fereira, Ennio; Chourio, José Colina

2008-03-01

385

Phase II Study of Sunitinib Malate, a Multi-Targeted Tyrosine Kinase Inhibitor in Patients with Relapsed or Refractory Soft Tissue Sarcomas. Focus on 3 Prevalent Histologies: Leiomyosarcoma, Liposarcoma, and Malignant Fibrous Histiocytoma  

Science.gov (United States)

SUMMARY Soft tissue sarcomas (STS) represent a diverse group of histologic subtypes with targetable molecular alterations, often treated as a single disease. Sunitinib malate is a multitargeted receptor tyrosine kinase inhibitor active in other solid tumors carrying similar alterations (i.e., imatinib mesylate-refractory gastrointestinal stromal tumors). This single-institution phase II study investigated the safety and efficacy of sunitinib malate in three common STS subtypes. Patients with documented unresectable or metastatic STS (liposarcoma, leiomyosarcoma, and malignant fibrous histiocytoma [MFH]), measurable disease, and 3 or less prior lines of therapy were eligible. Treatment consisted of sunitinib malate, 50 mg daily, for 4 weeks every 6 weeks. Forty-eight patients were enrolled, and 35% were heavily pretreated (?2 prior lines of chemotherapy). The safety profile resembled previously known sunitinib malate toxicities. Median progression-free and overall survivals for liposarcoma, leiomyosarcoma, and MFH were 3.9 and 18.6, 4.2 and 10.1, and 2.5 and 13.6 months, respectively. The 3-month progression-free rates in the untreated and pretreated (chemotherapy) patients with liposarcoma, leiomyosarcoma, and MFH were 75% and 69.2%, 60%, and 62.5%, and and 25% and 44.4%, respectively. With the caveats that a minority of patients with potentially indolent or low-grade disease could have been included and the small numbers, a 3-month progression-free rate of >40% suggests activity for sunitinib malate at least in liposarcomas and leiomyosarcomas. Thus, we believe that further investigation in these susceptible STS subtypes is warranted.

Mahmood, S. Tariq; Agresta, Samuel; Vigil, Carlos; Zhao, Xiuhua; Han, Gang; D'Amato, Gina; Calitri, Ciara E.; Dean, Michelle; Garrett, Christopher; Schell, Michael J.; Antonia, Scott; Chiappori, Alberto

2013-01-01

386

Fatal Case of Metastatic Cellular Fibrous Histiocytoma: Case Report and Review of Literature.  

UK PubMed Central (United Kingdom)

BACKGROUND:: Cellular fibrous histiocytoma was first described in 1994 as a distinct variant of fibrous histiocytoma. Since then, at least 21 cases of cellular fibrous histiocytomas metastasizing to regional lymph nodes and/or lungs have been described, though not all fatal. CASE:: We report the case of a 68-year-old male patient who presented with a large ulcerated skin tumor on the left thigh. The lesion was urgently excised. Histopathological examination led to the diagnosis of cellular fibrous histiocytoma. Nine months later, the patient presented with progressive dyspnea. A thoracoabdominal computed tomography revealed diffusely spread nodular lung lesions. A lung biopsy confirmed them to be metastases of the cellular fibrous histiocytoma. The condition of the patient quickly deteriorated, and he deceased 2 months later. CONCLUSIONS:: Given the possible aggressive nature of cellular type of fibrous histiocytoma, we advice complete excision and clinical follow-up. Chest x-rays and ultrasound examination of regional lymph nodes should be performed in atypical lesions.

Lodewick E; Avermaete A; Blom WA; Lelie B; Block R; Keuppens M

2013-09-01

387

Benign fibrous histiocytoma presenting as anal canal polyp: first case report.  

UK PubMed Central (United Kingdom)

Nonepithelial and nonmelanocytic anal neoplasms are uncommon. The majority are mesenchymal tumors, most of which are malignant sarcomas, particularly leiomyosarcomas and gastrointestinal stromal tumors. Benign mesenchymal anal neoplasms are even rarer. The most common reported cases were anal leiomyomas, granular cell tumors, fibroadenomas, and xanthogranulomas. Benign fibrous histiocytomas (BFHs) or dermatofibromas are common mesenchymal cutaneous tumors that occur in different sites and at any age. Review of the literature did not show previous reports of BFH arising in the anal canal region. We report the first case of a solitary BFH, an unexpected occurrence of a common tumor type presenting as a polyp in an unusual site such as the anus. This rare occurrence can present diagnostic challenges for the surgeons and pathologists. Clinically, it can be confused with the usual anal tags, fibroepithelial polyps, or hemorrhoids. Benign fibrous histiocytoma is a neoplasm with a potential of local recurrence and, therefore, carries certain clinical implications for the patients' management and follow-up when compared with the common nonneoplastic causes of anal polyps such as the anal tags of anal fissures, hemorrhoids, or fibroepithelial papilla. Histologically, it should be differentiated from other histiocytic lesions. This can be resolved by the application of certain histologic features with the appropriate immunohistochemical markers taken within the correct clinical context.

Abdullgaffar B; Abdulrahim M; Ghazi E

2013-10-01

388

Atypical Fibrous Histiocytoma Arising in the Perianal Area: A Case Report and Review of the Literature.  

UK PubMed Central (United Kingdom)

: Atypical fibrous histiocytoma (AFH) is an uncommon variant of cutaneous fibrous histiocytoma that can display histologic features associated with malignancy. Fewer than 150 cases have been reported in the literature. The majority of these lesions present on the trunk and extremities of middle-aged women. Genital lesions are rare, with one documented case of vulvar AFH and another case of scrotal AFH in the literature. We report an additional case of a 68-year-old woman who was diagnosed with an AFH in an unusual location, the perianal area. Histologically, the lesion was characterized by a nodular fairly well-circumscribed proliferation of large epithelioid macrophages with scattered lymphocytes and mast cells in the background. The atypical macrophages contained enlarged markedly pleomorphic nuclei with prominent nucleoli. Scattered multinucleated "monster cells" and atypical mitoses were observed throughout the lesion. Immunologically, the lesional cells were focally positive when stained with antibodies against CD163 and Factor XIIIa. They were negative for CD34, CD31, desmin, smooth muscle actin, CAM 5.2, keratin 5/6, S100, CD3, CD20, and CD30. The constellation of histologic and immunologic features was most consistent with an AFH. To our knowledge, this case is the first perianal presentation of AFH to date.

Wang YT; Smart CN

2013-09-01

389

Benign fibrous histiocytoma presenting as anal canal polyp: first case report.  

Science.gov (United States)

Nonepithelial and nonmelanocytic anal neoplasms are uncommon. The majority are mesenchymal tumors, most of which are malignant sarcomas, particularly leiomyosarcomas and gastrointestinal stromal tumors. Benign mesenchymal anal neoplasms are even rarer. The most common reported cases were anal leiomyomas, granular cell tumors, fibroadenomas, and xanthogranulomas. Benign fibrous histiocytomas (BFHs) or dermatofibromas are common mesenchymal cutaneous tumors that occur in different sites and at any age. Review of the literature did not show previous reports of BFH arising in the anal canal region. We report the first case of a solitary BFH, an unexpected occurrence of a common tumor type presenting as a polyp in an unusual site such as the anus. This rare occurrence can present diagnostic challenges for the surgeons and pathologists. Clinically, it can be confused with the usual anal tags, fibroepithelial polyps, or hemorrhoids. Benign fibrous histiocytoma is a neoplasm with a potential of local recurrence and, therefore, carries certain clinical implications for the patients' management and follow-up when compared with the common nonneoplastic causes of anal polyps such as the anal tags of anal fissures, hemorrhoids, or fibroepithelial papilla. Histologically, it should be differentiated from other histiocytic lesions. This can be resolved by the application of certain histologic features with the appropriate immunohistochemical markers taken within the correct clinical context. PMID:22999485

Abdullgaffar, Badr; Abdulrahim, Manal; Ghazi, Esaaf

2012-09-19

390

[Benign fibrous histiocytoma of the distal femoral metaphysis. Differential diagnosis between neoplasm and growth disorder with identical morphology  

UK PubMed Central (United Kingdom)

The typical radiologic finding of a "non-ossifying fibroma" of the distal femoral metaphysis was seen in a 17-year-old female patient with pain in the distal femur. The rapid development of this lesion was confirmed on the basis of earlier radiographs performed to clarify other complaints. Since the lesion had developed in no more than 34 months, with pronounced scintigraphic and MRI signal intensity, particularly in the late phase, and pain had prompted the patient to seek examination, the cause was assumed to be a neoplasia rather than a growth disorder. Histopathological examination revealed a proliferative fibrohistiocytic lesion which was histologically different from a malignant fibrous histiocytoma. The finding indicates that in the differential diagnosis between non-ossifying fibroma and benign fibrous histiocytoma in cases with identical localization, pain and the intensity of the scintigraphic signal may well be the key to further action: since benign fibrous histiocytomas may be regarded as genuine neoplasias, the question of malignancy should also be clarified beyond doubt.

Exner GU; von Hochstetter AR; Uehlinger K

1990-05-01

391

[Malignant fibrous histiocytoma of the larynx].  

Science.gov (United States)

Clinical description of a case of FMH in a 77 years-old man, heavy smoker and diabetic. At the beginning its appearance mimic a small polyp of the middle third of the right vocal cord. The patient refused any treatment at first, but one year later, when seen again in the office, a mass covering-up the right hemilarynx was detected and a total laryngectomy was advised and done. In spite of the correctness of the follow-up in the next six months, the unhappy commit suicide. PMID:1315126

Rossi Vargas, J; Bal Nieves, F; Carbayeda Sánchez, M; Corredoira Ferreiro, M; Pena Rabade, P; Alonso Rodríguez, J R

1992-01-01

392

[Malignant fibrous histiocytoma of the larynx  

UK PubMed Central (United Kingdom)

Clinical description of a case of FMH in a 77 years-old man, heavy smoker and diabetic. At the beginning its appearance mimic a small polyp of the middle third of the right vocal cord. The patient refused any treatment at first, but one year later, when seen again in the office, a mass covering-up the right hemilarynx was detected and a total laryngectomy was advised and done. In spite of the correctness of the follow-up in the next six months, the unhappy commit suicide.

Rossi Vargas J; Bal Nieves F; Carbayeda Sánchez M; Corredoira Ferreiro M; Pena Rabade P; Alonso Rodríguez JR

1992-01-01

393

Malignant fibrous histiocytoma with progressive systemic sclerosis  

Directory of Open Access Journals (Sweden)

Full Text Available Forty years old female, suffering from progressive systemic sclerosis of six years duration presented with a proliferative growth over the right fore-arm showing sclerodermatous changes. Started as a small nodule gradually increasing in size over the course of six months to the size of 10 cms x 10 cms. The tender proliferative bluish red growth having multiple bleeding points. the base fixed to the underlying bone with no evidence of regional lymphadenopathy.

Sundaram M; Prabhavathy D; Ratnavelu P; Rajasingam J; Sugantha R

1994-01-01

394

Infiltrative corneal lesions resembling fibrous histiocytoma: clinical and pathologic findings in six dogs and one cat.  

UK PubMed Central (United Kingdom)

Infiltrating corneal lesions developed in 6 dogs and 1 cat. In each case, the site of origin appeared to be the corneal limbus. The lesions were characterized by continuous growth, a benign appearance, and a tendency to recur following excision keratoplasty. Each lesion was of a proliferative, inflammatory nature, histologically resembling fibrous histiocytoma. Of the 6 dogs in the series, 4 were Collies.

Smith JS; Bistner S; Riis R

1976-10-01

395

Surgical Treatment of Benign Fibrous Histiocytoma as a Form of Intraspinal Extradural Tumor at Lumbar Spine  

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A benign fibrous histiocytoma (BFH) is one of the fibrohistiocytic groups of soft-tissue tumors for which spinal involvement is extremely rare. To the best of our knowledge, most spine-originating BFHs are bone tumors. We report the first case of BFH occurring in the intraspinal extradural space on ...

Kim, Soo-Beom; Jang, Jee-Soo; Lee, Sang-Ho

396

Benign fibrous histiocytoma of bone: a report of ten cases and review of literature.  

Science.gov (United States)

The benign fibrous histiocytoma is a rare tumor with only a few descriptions. In order to better define the optimal therapeutic procedure and the necessity of surgery we retrospectively analyzed the patients of the orthopedic department. Benign fibrous histiocytoma occurred in the femur (n = 3), pelvis (n = 2), humerus, tibia, fibula, rib and spine. Pain as the cardinal symptom and a median age of 28 years are factors that differentiate benign fibrous histiocytoma from other metaphyseal fibrous lesions such as the nonossifying fibroma. Radiographic investigation of this entity showed osteolytic lesions with eccentric thinning of the cortex and small fissures. To a variable extent, sclerosis was found in the margin of the lesions. Computer tomography revealed dense soft tissue in the lesions, but one lesion was filled with fluid. The tumor was restricted to bone, with no periosteal or soft tissue reaction. Magnetic resonance imaging showed enhancement of the tumor after administration of contrast medium. All lesions had uniform histological findings. Although no pathologic fracture occurred in any case, local expansion of the tumor was indicated by cortical thinning, small fissures and pain. This implied that the patients needed prophylactic curettage and bone grafting. Surgery restricted to the osteolytic area was sufficient to prevent recurrence. PMID:12407938

Grohs, Josef G; Nicolakis, Michael; Kainberger, Franz; Lang, Susanna; Kotz, Rainer

2002-01-15

397

Benign fibrous histiocytoma of bone: a report of ten cases and review of literature.  

UK PubMed Central (United Kingdom)

The benign fibrous histiocytoma is a rare tumor with only a few descriptions. In order to better define the optimal therapeutic procedure and the necessity of surgery we retrospectively analyzed the patients of the orthopedic department. Benign fibrous histiocytoma occurred in the femur (n = 3), pelvis (n = 2), humerus, tibia, fibula, rib and spine. Pain as the cardinal symptom and a median age of 28 years are factors that differentiate benign fibrous histiocytoma from other metaphyseal fibrous lesions such as the nonossifying fibroma. Radiographic investigation of this entity showed osteolytic lesions with eccentric thinning of the cortex and small fissures. To a variable extent, sclerosis was found in the margin of the lesions. Computer tomography revealed dense soft tissue in the lesions, but one lesion was filled with fluid. The tumor was restricted to bone, with no periosteal or soft tissue reaction. Magnetic resonance imaging showed enhancement of the tumor after administration of contrast medium. All lesions had uniform histological findings. Although no pathologic fracture occurred in any case, local expansion of the tumor was indicated by cortical thinning, small fissures and pain. This implied that the patients needed prophylactic curettage and bone grafting. Surgery restricted to the osteolytic area was sufficient to prevent recurrence.

Grohs JG; Nicolakis M; Kainberger F; Lang S; Kotz R

2002-01-01

398

Piezoelectric-assisted removal of a benign fibrous histiocytoma of the mandible: An innovative technique for prevention of dentoalveolar nerve injury  

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Full Text Available Abstract In this article, we present our experience with a piezoelectric-assisted surgical device by resection of a benign fibrous histiocytoma of the mandible. A 41 year-old male was admitted to our hospital because of slowly progressive right buccal swelling. After further radiographic diagnosis surgical removal of the yellowish-white mass was performed. Histologic analysis showed proliferating histiocytic cells with foamy, granular cytoplasm and no signs of malignancy. The tumor was positive for CD68 and vimentin in immunohistochemical staining. Therefore the tumor was diagnosed as primary benign fibrous histiocytoma. This work provides a new treatment device for benign mandibular tumour disease. By using a novel piezoelectric-assisted cutting device, protection of the dentoalveolar nerve could be achieved.

Wagner Maximilian EH; Rana Majeed; Traenkenschuh Wolfgang; Kokemueller Horst; Eckardt André M; Gellrich Nils-Claudius

2011-01-01

399

Case report 503: 1. Giant cell tumor of sacrum. 2. Fibrous histiocytoma of ischium (benign). 3. Fibrous histiocytoma of tibia (benign)  

International Nuclear Information System (INIS)

The radiological and pathological skeletal manifestations in a case of multicentric fibrohistiocytic tumor are presented. The authors have emphasized a possible common histiogenesis of the three lesions. In a review of the world literature, no other example of a giant-cell tumor of bone and benign fibrous histiocytoma in one and the same patient could be found, but references must be made to cases with multifocal giant-cell tumors of bone. Of interest, recently reports of experiences with intralesionally excised giant cell tumors with temporary methacrylate implantation lowering local recurrence rates have appeared. (orig.)

1989-01-01

400

Case report 503: 1. Giant cell tumor of sacrum. 2. Fibrous histiocytoma of ischium (benign). 3. Fibrous histiocytoma of tibia (benign)  

Energy Technology Data Exchange (ETDEWEB)

The radiological and pathological skeletal manifestations in a case of multicentric fibrohistiocytic tumor are presented. The authors have emphasized a possible common histiogenesis of the three lesions. In a review of the world literature, no other example of a giant-cell tumor of bone and benign fibrous histiocytoma in one and the same patient could be found, but references must be made to cases with multifocal giant-cell tumors of bone. Of interest, recently reports of experiences with intralesionally excised giant cell tumors with temporary methacrylate implantation lowering local recurrence rates have appeared.

Wuisman, P.; Roessner, A.; Haerle, A.; Erlemann, R.; Reiser, M.; Schmidt, M.

1989-01-01

 
 
 
 
401

Malignant solitary fibrous tumour of the bronchus.  

UK PubMed Central (United Kingdom)

Solitary fibrous tumours most commonly present in the pleura, but have been reported in other extrapleural sites. We present a case of an elderly female who was found to have a malignant solitary fibrous tumour of the right upper lobe bronchus, treated with thoracoscopic lobectomy and bronchoplastic closure.

Okereke IC; Frick DJ; Sheski FD; Cummings OW

2013-05-01

402

Case report 444: Subperiosteal malignant fibrous histocytoma (MFH) of thigh, with involvement of femur  

Energy Technology Data Exchange (ETDEWEB)

A case has been presented of subperiosteal malignant fibrous histiocytoma of the thigh eroding the femur in a 35-year-old woman. Plain films, radioisotope scans and CT studies were obtained. The lesion was mainly in the soft tissues but eroded the cortex of the femur. A local resection was performed with an excellent result (5-year-follow-up). The clinical, radiological and histological features of malignant fibrous histiocytoma were discussed in depth and the current modes of therapy were detailed. It was stressed that the lesion closely resembles fibrosarcoma and that eccentric lesions have a better prognosis than lesions arising directly in the marrow cavity of bone. Manifestations of this tumor at an atypical site initially presented difficulty in the clinical diagnosis. However, the histological pattern in association with the presence of giant cells confirmed the diagnosis, despite the absence of the typical storiform pattern in the tumor tissue.

Kemp, H.B.S.; Byers, P.D.

1987-10-01

403

Case report 444: Subperiosteal malignant fibrous histocytoma (MFH) of thigh, with involvement of femur  

International Nuclear Information System (INIS)

A case has been presented of subperiosteal malignant fibrous histiocytoma of the thigh eroding the femur in a 35-year-old woman. Plain films, radioisotope scans and CT studies were obtained. The lesion was mainly in the soft tissues but eroded the cortex of the femur. A local resection was performed with an excellent result (5-year-follow-up). The clinical, radiological and histological features of malignant fibrous histiocytoma were discussed in depth and the current modes of therapy were detailed. It was stressed that the lesion closely resembles fibrosarcoma and that eccentric lesions have a better prognosis than lesions arising directly in the marrow cavity of bone. Manifestations of this tumor at an atypical site initially presented difficulty in the clinical diagnosis. However, the histological pattern in association with the presence of giant cells confirmed the diagnosis, despite the absence of the typical storiform pattern in the tumor tissue. (orig.).

1987-01-01

404

Histiocitomas fibrosos: revisão histopatológica de 95 casos/ Fibrous histiocytomas: histopathologic review of 95 cases  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O histiocitoma fibroso é tumor heterogéneo composto por fibroblastos, histiócitos e vasos sanguíneos. Efectuamos uma revisão histopatológica retrospectiva de 95 biopsias de histiocitomas fibrosos do nosso arquivo dos últimos 3,5 anos, com o objectivo de avaliar a localização, delimitação, alteração da epiderme, indução folículo-sebácea, celularidade, vascularização, padrão do colagénio e tipo de células constituintes. Na maioria das biopsias, confirm (more) amos as características histopatológicas clássicas dos histiocitomas fibrosos. Achados interessantes observados no nosso estudo foram presença de células nódulos linfoides, mastócitos e infiltrado de células inflamatórias. Abstract in english Fibrous histiocytoma (FH) is a heterogeneous tumor composed of fibroblasts, histiocytes, and blood vessels. We conducted a retrospective histopathologic analysis of 95 biopsies, performed over the last 3.5 years, of fibrous histiocytomas to analyze the location, delimitation, epithelial changes, induction of folliculo-sebaceous structures, cellularity, vascularity, collagen pattern, and types of composite cells of the FH. In the majority of the biopsies, we confirmed the (more) classical histopathologic features of fibrous histiocytomas. The presence of lymphoid nodules, mast cells, and sparse infiltrate of inflammatory cells was an interesting finding observed in our study.

Canelas, Maria Miguel Camelo Amaral; Cardoso, José Carlos Pereira da Silva; Andrade, Pedro Filipe; Reis, José Pedro Gaspar dos; Tellechea, Oscar

2010-04-01

405

Histiocitomas fibrosos: revisão histopatológica de 95 casos Fibrous histiocytomas: histopathologic review of 95 cases  

Directory of Open Access Journals (Sweden)

Full Text Available O histiocitoma fibroso é tumor heterogéneo composto por fibroblastos, histiócitos e vasos sanguíneos. Efectuamos uma revisão histopatológica retrospectiva de 95 biopsias de histiocitomas fibrosos do nosso arquivo dos últimos 3,5 anos, com o objectivo de avaliar a localização, delimitação, alteração da epiderme, indução folículo-sebácea, celularidade, vascularização, padrão do colagénio e tipo de células constituintes. Na maioria das biopsias, confirmamos as características histopatológicas clássicas dos histiocitomas fibrosos. Achados interessantes observados no nosso estudo foram presença de células nódulos linfoides, mastócitos e infiltrado de células inflamatórias.Fibrous histiocytoma (FH) is a heterogeneous tumor composed of fibroblasts, histiocytes, and blood vessels. We conducted a retrospective histopathologic analysis of 95 biopsies, performed over the last 3.5 years, of fibrous histiocytomas to analyze the location, delimitation, epithelial changes, induction of folliculo-sebaceous structures, cellularity, vascularity, collagen pattern, and types of composite cells of the FH. In the majority of the biopsies, we confirmed the classical histopathologic features of fibrous histiocytomas. The presence of lymphoid nodules, mast cells, and sparse infiltrate of inflammatory cells was an interesting finding observed in our study.

Maria Miguel Camelo Amaral Canelas; José Carlos Pereira da Silva Cardoso; Pedro Filipe Andrade; José Pedro Gaspar dos Reis; Oscar Tellechea

2010-01-01

406

A Rare Case Of Benign Fibrous Histiocytoma In The Submucosal Soft Tissue Of Hard Palate :A Case Report And Review Of Literature  

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Full Text Available Benign fibrous histiocytoma is a benign soft tissue tumor commonly seen in the skin extremities. It can arise as a soft tissue mass anywhere in the human body, but involvement of the oral cavity is very rare. Here we present a case of benign fibrous histiocytoma involving the posterior region of the hard palate.

P.R. Bindhu; S.K. Padmakumar; Priya Thomas; Julie Jacob

2012-01-01

407

Pleomorphic malignant histiocytoma of pulmonary arteries presenting as pulmonary aneurysms.  

Science.gov (United States)

Pulmonary aneurysms and primary neoplasms of the great vessels are very rare entities; pulmonary aneurysms are commonly associated with congenital heart diseases, and less frequently in atherosclerosis, medial cystic necrosis, trauma, infection, and inflammatory processes. Many patients have pulmonary hypertension, most frequently resulting from pulmonary artery sarcomas mimicking pulmonary thromboembolism. Symptoms are vague. In 30% of cases, rupture and death occur, related to pulmonary aneurysms. We present the case of a patient with a diagnosis of pulmonary artery pleomorphic malignant histiocytoma that presented as a right pulmonary aneurysm thrombosis and a contained rupture of a left pulmonary aneurysm. PMID:23438543

De La Cerda Belmont, Gustavo Armando; Lezama Urtecho, Carlos Alberto

2013-03-01

408

Pleomorphic malignant histiocytoma of pulmonary arteries presenting as pulmonary aneurysms.  

UK PubMed Central (United Kingdom)

Pulmonary aneurysms and primary neoplasms of the great vessels are very rare entities; pulmonary aneurysms are commonly associated with congenital heart diseases, and less frequently in atherosclerosis, medial cystic necrosis, trauma, infection, and inflammatory processes. Many patients have pulmonary hypertension, most frequently resulting from pulmonary artery sarcomas mimicking pulmonary thromboembolism. Symptoms are vague. In 30% of cases, rupture and death occur, related to pulmonary aneurysms. We present the case of a patient with a diagnosis of pulmonary artery pleomorphic malignant histiocytoma that presented as a right pulmonary aneurysm thrombosis and a contained rupture of a left pulmonary aneurysm.

De La Cerda Belmont GA; Lezama Urtecho CA

2013-03-01

409

A CASE REPORT OF BENIGN FIBROUS HISTIOCYTOMA OF PARANASAL SINUSES AND ROLE OF TRANSNASAL ENDOSCOPY IN ITS TREATMENT  

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Full Text Available Benign fibrous histiocytoma is a rare tumor of nose and paranasal sinuses that originates from histiocytes. ??The main symptoms of patients are nasal obstruction and nasal mass. ?Our patient was presented with chief complaints of nasal obstruction and rhinorrhea non responsive to antibiotic treatment. In computed tomography scan a giant mass in left maxillary sinus and ipsilateral nasal cavity was seen. After en bloc resection of tumor by transnasal endoscopic approach all of patient’s symptoms were alleviated. The pathologic report was benign fibrous histiocytoma. ?Because of excellent visualization, it seems that transnasal endoscopic approach is the method of choice for resection of these benign tumors.

M. H. Baradaranfar M. Moghimi

2005-01-01

410

Deep benign fibrous histiocytoma of the knee: CT and MR features with pathologic correlation  

Energy Technology Data Exchange (ETDEWEB)

Magnetic resonance imaging and pathologic findings in a 28-year-old patient with a giant deep benign fibrous histiocytoma in the popliteal fossa of the right knee are described. The MR imaging findings include a well-delineated oval mass with low signal intensity on T1-, and high signal intensity on T2-weighted, images, and marked peripheral contrast enhancement. To the best of our knowledge, this is the first report on the MR findings in this entity. (orig.) With 4 figs., 8 refs.

Machiels, F.; Maeseneer, M. de; Osteaux, M. [Department of Radiology, Academic Hospital of the Free University, Brussels (Belgium); Chaskis, C. [Department of Neurosurgery, Academic Hospital of the Free University of Brussels (Belgium); Bourgain, C. [Department of Pathology, Academic Hospital of the Free University of Brussels (Belgium)

1998-07-01

411

Histiocitoma fibroso do saco lacrimal: relato de um caso Lacrimal sac fibrous histiocytoma: case report  

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Full Text Available Os autores descrevem um caso raro de histiocitoma fibroso acometendo o saco lacrimal. A paciente apresentava quadro clínico que simulava dacriocistite crônica, com dacriocistografia sugestiva de obstrução alta das vias lacrimais. A completa remoção cirúrgica do tumor e posterior dacriocistorrinostomia foram fundamentais no diagnóstico e controle da doença.The authors report an unusual case of fibrous histiocytoma of the lacrimal sac. The patient presented with clinical features of chronic dacryocystitis. Dacryocystogram disclosed a high level obstruction. Surgical management was fundamental to the diagnosis and control of the disease.

Carolina Lemos Curi; Everaldo Lemos; Eduardo Pereira de Macedo; Virgínia Bohrer Costa

2003-01-01

412

Histiocitoma fibroso do saco lacrimal: relato de um caso/ Lacrimal sac fibrous histiocytoma: case report  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Os autores descrevem um caso raro de histiocitoma fibroso acometendo o saco lacrimal. A paciente apresentava quadro clínico que simulava dacriocistite crônica, com dacriocistografia sugestiva de obstrução alta das vias lacrimais. A completa remoção cirúrgica do tumor e posterior dacriocistorrinostomia foram fundamentais no diagnóstico e controle da doença. Abstract in english The authors report an unusual case of fibrous histiocytoma of the lacrimal sac. The patient presented with clinical features of chronic dacryocystitis. Dacryocystogram disclosed a high level obstruction. Surgical management was fundamental to the diagnosis and control of the disease.

Curi, Carolina Lemos; Lemos, Everaldo; Macedo, Eduardo Pereira de; Costa, Virgínia Bohrer

2003-01-01

413

Fibroistiocitoma angiomatóide com metástase ao diagnóstico: relato de caso e revisão da literatura Angiomatoid fibrous histiocytoma presenting metastasis: case report and literature review  

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Full Text Available O fibroistiocitoma maligno variante angiomatóide constitui entidade rara e geradora de controvérsia, especialmente quanto a sua histogênese. Apresenta como peculiaridades o acometimento preferencial da faixa etária pediátrica e o comportamento biológico indolente, tendo baixas taxas de metastatização. No presente caso, paciente feminina de 6 anos apresentou, em decorrência de lesão em extremidade inferior, metástase linfonodal inguinal.Angiomatoid malignant fibrous histiocytoma is a rare and controversial entity, particularly as to its histogenesis. The tumor affects mostly the pediatric group, with an indolent clinical course and low rate of metastatization. In this report, the patient presented a lesion in the right foot and metastasis in an inguinal lymph node.

Thaís Heinke; Marcello Franco; Maria Teresa de Seixas Alves; Lucila Böhme Pellacani; Ângela Navarro Gordan; Antonio Sérgio Petrilli

2004-01-01

414

Fibrohistiocitoma benigno ósseo na coluna lombar Benign fibrous histiocytoma of the lumbar spine  

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Full Text Available CONTEXTO: O fibrohistiocitoma benigno intra-ósseo é uma neoplasia rara, caracterizada por proliferação fibroblástica e fibras colágenas. A dor na região lombar é uma queixa freqüente em muitos pacientes, mas, na maioria das vezes está relacionada com causa muscular ou degenerativa. RELATO DE CASO: Relata-se aqui o caso de um paciente com diagnóstico de fibrohistiocitoma benigno ósseo na coluna lombar que apresentava queixa de lombalgia há cinco meses antes do diagnóstico. Foi submetida à biópsia aberta transpedicular na quarta vértebra lombar ,e, posteriormente realizada curetagem da lesão via anterior retroperitonial e artrodese vertebral de L3-L5 com enxerto de fíbula. CONCLUSÃO: Apesar de raro, o fibrohistiocitoma benigno intra-ósseo deve ser uma das hipóteses quando observamos uma lesão primária na coluna vertebral.CONTEXT: Benign intraosseous fibrous histiocytoma is a rare neoplasia, characterized by fibroblastic and collagenous fiber proliferation. Pain in the lumbar region is a frequent complaint in many patients, but most of times it is associated to muscular or degenerative causes. CASE REPORT: Here we report a case of a patient diagnosed with benign bone fibrous histiocytoma in the lumbar spine who complained of lumbar pain dating five months prior to diagnosis. The patient was submitted to open transpedicular biopsy in the forth lumbar vertebra, and subsequently, lesion curettage was performed via anterior retroperitoneal and L3-L5 vertebral arthrodesis using a fibular graft. CONCLUSION: Although rare, benign intraosseous fibrohistiocytoma should be taken into consideration when a primary lesion is observed in the spine.

Osmar Avanzi; Lin Yu Chih; Robert Meves; José Donato Próspero; Amarildo Brito

2005-01-01

415

Deep benign fibrous histiocytoma: computed tomography and histology findings; Histiocitoma fibroso benigno profundo: achados na tomografia computadorizada e histologia  

Energy Technology Data Exchange (ETDEWEB)

We present the computed tomography images of an 83-year-old male patient with a deep benign fibrous histiocytoma at the lateral aspect of the left leg. Computed tomography images showed a well-defined mass with marked peripheral enhancement by iodinated contrast medium. Only few reports of this rare soft tissue tumor can be found in the literature. (author)

Farage, Luciano; Castro, Mario Augusto Padula; Macedo, Tulio Augusto Alves [Uberlandia Univ., MG (Brazil). Hospital das Clinicas. Setor de Radiologia; Salomao, Eliana Chaves; Machado, Tania Alcantara; Souza, Lincoln Pereira de; Freitas, Luiz de Oliveira [Uberlandia Univ., MG (Brazil). Faculdade de Medicina. Dept. de Clinica Medica

2005-04-01

416

A CASE REPORT OF BENIGN FIBROUS HISTIOCYTOMA OF PARANASAL SINUSES AND ROLE OF TRANSNASAL ENDOSCOPY IN ITS TREATMENT  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Benign fibrous histiocytoma is a rare tumor of nose and paranasal sinuses that originates from histiocytes. ??The main symptoms of patients are nasal obstruction and nasal mass. ?Our patient was presented with chief complaints of nasal obstruction and rhinorrhea non responsive to antibiotic treatmen...

M. H. Baradaranfar M. Moghimi

417

Orbital fibrous histiocytoma mimicking cavernous hemangioma on dynamic contrast-enhanced MRA imaging.  

Science.gov (United States)

Orbital lesions include a broad spectrum of tumors, vascular abnormalities, and inflammatory conditions. High-resolution imaging has become an invaluable tool toward formulating an accurate diagnosis, and facilitates proper counseling regarding appropriate interventions. Imaging may guide whether partial excision to minimize damage to orbital structures, or en bloc removal to prevent potential recurrence, as seen in mesenchymal tumors, is indicated., Recently, dynamic contrast-enhanced magnetic resonance angiography (MRA) has demonstrated use in helping differentiate orbital vascular lesions. This imaging modality uses rapid MRI acquisition to provide noninvasive, dynamic flow information with high spatial resolution. However, even with modern imaging, reaching a diagnosis prior to histopathological analysis can be challenging. We present a case of orbital fibrous histiocytoma that appeared nearly identical to cavernous hemangioma on dynamic contrast-enhanced MRA. PMID:22836792

Warner, Evan J; Burkat, Cat N; Gentry, Lindell R

2013-01-01

418

Fibrohistiocitoma benigno ósseo na coluna lombar/ Benign fibrous histiocytoma of the lumbar spine  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese CONTEXTO: O fibrohistiocitoma benigno intra-ósseo é uma neoplasia rara, caracterizada por proliferação fibroblástica e fibras colágenas. A dor na região lombar é uma queixa freqüente em muitos pacientes, mas, na maioria das vezes está relacionada com causa muscular ou degenerativa. RELATO DE CASO: Relata-se aqui o caso de um paciente com diagnóstico de fibrohistiocitoma benigno ósseo na coluna lombar que apresentava queixa de lombalgia há cinco meses antes do (more) diagnóstico. Foi submetida à biópsia aberta transpedicular na quarta vértebra lombar ,e, posteriormente realizada curetagem da lesão via anterior retroperitonial e artrodese vertebral de L3-L5 com enxerto de fíbula. CONCLUSÃO: Apesar de raro, o fibrohistiocitoma benigno intra-ósseo deve ser uma das hipóteses quando observamos uma lesão primária na coluna vertebral. Abstract in english CONTEXT: Benign intraosseous fibrous histiocytoma is a rare neoplasia, characterized by fibroblastic and collagenous fiber proliferation. Pain in the lumbar region is a frequent complaint in many patients, but most of times it is associated to muscular or degenerative causes. CASE REPORT: Here we report a case of a patient diagnosed with benign bone fibrous histiocytoma in the lumbar spine who complained of lumbar pain dating five months prior to diagnosis. The patient wa (more) s submitted to open transpedicular biopsy in the forth lumbar vertebra, and subsequently, lesion curettage was performed via anterior retroperitoneal and L3-L5 vertebral arthrodesis using a fibular graft. CONCLUSION: Although rare, benign intraosseous fibrohistiocytoma should be taken into consideration when a primary lesion is observed in the spine.

Avanzi, Osmar; Chih, Lin Yu; Meves, Robert; Próspero, José Donato; Brito, Amarildo

2005-01-01

419

Transformed chest chardomas in malignant fibrous histiocytorme: presentation of case and reviewing of literature. Cardoma toracico transformado en histiocitima fibroso maligno: presentacion del caso y revision de la literatura  

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Chest chordomas are rare neoplasms, and their transformation into malignant fibrous histiocytoma (MFH) is even more exceptional. We present a new case, including magnetic resonance (MR) images. The literature on the subject is reviewed, focussing especially on the dorsal location of these neoplasms and their possible malignant transformation, as well as the role of MR in the assessment of these lesions. (Author)

Capelastegui, A.; Mateos, B.; Astigarraga, E.; Pastor, A.; Pomposo, I.; Egurbide, M.V.

1994-01-01

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Angiomatoid fibrous histiocytoma: clinicopathological and molecular characterisation with emphasis on variant histomorphology.  

UK PubMed Central (United Kingdom)

AIMS: Angiomatoid fibrous histiocytoma (AFH) is histologically typified by nodules of histiocytoid spindle cells with pseudoangiomatoid spaces, fibrous pseudocapsules and lymphocytic cuffs. The principal goal was to expand the spectrum of AFHs through clinicopathological and molecular characterisation. METHODS: Thirteen AFHs, including 11 with confirmed hallmark translocation, were reappraised for classic features, reactive osteoclasts, mitoses and stromal, architectural and cytomorphological variations, with CD99, desmin and EMA stained in available cases. RESULTS: Seven male and six female patients ranged in age from 4 to 63 years (median, 13), including 4 older than 20 years. Tumours were located on the extremities (n=6), trunk (n=4) and scalp (n=3). Although fibrous pseudocapsules were observed in all cases, four showed solid histology without pseudoangiomatoid spaces and another one lacked peripheral lymphoid infiltrates. Nuclear pleomorphism was striking in two cases, moderate in seven and absent in four, with osteoclasts seen in two cases. In three AFHs with sclerotic matrix, one exhibited perivascular hyalinisation and nuclear palisading, reminiscent of a schwannoma. In three varyingly myxoid tumours, one closely resembled a myoepithelioma with prominent reticular arrangement of spindle cells in an abundant myxoid stroma. Besides EWSR1 gene rearrangement detected in four cases by fluorescence in situ hybridisation (FISH), EWSR1-CREB1 fusion was confirmed in nine cases, including a schwannoma-like AFH, and EWSR1-ATF1 fusion detected in a myoepithelioma-like AFH. Immunohistochemically, 56% of AFHs were positive for EMA, 78% for desmin and 100% for CD99. CONCLUSIONS: Molecular testing is diagnostic of variant AFHs displaying diverse histomorphological alterations in the architectural patterns, cytomorphology and extracellular matrix.

Kao YC; Lan J; Tai HC; Li CF; Liu KW; Tsai JW; Fang FM; Yu SC; Huang HY

2013-09-01