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Sample records for malignant fibrous histiocytomas

  1. Intraperitoneal malignant fibrous histiocytoma

    International Nuclear Information System (INIS)

    Two cases of liver metastasis detected in the follow-up of intraperitoneal malignant fibrous histiocytoma (MFH) are reported. Both patients were studied by ultrasonography (US) and computerized tomography (CT), accompanied in the follow-up study by magnetic resonance. (Author)

  2. Primary Pulmonary Malignant Fibrous Histiocytoma

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    Patel, Devin P.; Gandhi, Yogesh S.; Sommers, Keith E.; Mangar, Devanand; Camporesi, Enrico M.

    2015-01-01

    Malignant fibrous histiocytoma (MFH) is one of the most common adult soft tissue sarcomas. MFH is very aggressive and is most often found in the extremities and the retroperitoneum, but it can manifest at other sites. Though the lungs are the most common sites of metastasis, they rarely present there as a primary tumor. Our report describes a rare case of a primary MFH tumor in the lung. Careful diagnostic procedure should be followed to ensure the tumor does not have extrapulmonary origins. Though MFH is highly invasive and deadly, surgical excision of the tumor has been shown to be successful.

  3. Radiation-induced intracranial malignant fibrous histiocytoma

    International Nuclear Information System (INIS)

    An autopsy case of radiation-induced intracranial malignant fibrous histiocytoma (fibroxanthosarcoma) is reported. The tumor developed in the region of the sella turcica 11 years after high dose radiotherapy of a chromophobe adenoma of the pituitary. The tumor had infiltrated the base of the brain as well as the base of the skull. Metastases were not found. The tumor was composed of an admixture of bizarre fibroblasts, histiocytes and giant cells, xanthoma cells and siderophages, with a storiform fibrous stroma. This appears to be the first documented instance of a malignant fibrous histiocytoma occurring intracranially after local x irradiation

  4. Malignant fibrous histiocytoma with skeletal involvement

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    Takechi,Hideo

    1978-10-01

    Full Text Available Malignant fibrous histiocytoma of soft part is rather common but malignant fibrous histiocytoma of the bone is rarely encountered clinically. Authors present five cases of malignant fibrous histiocytoma with skeletal involvement and discuss their clinical course, x-ray findings and histological features. This tumor has marked tendency for local recurrence and metastasis. Other bone tumors such as giant cell tumor, aneurysmal bone cyst, non ossifying fibroma, osteosarcoma, fibrosarcoma of bone and metastatic cancer can be excluded by several characteristic findings observed in x-rays as well as histopathological features. All information on the patient should be carefully analysed, because it is difficult to decide whether bone involvement is primary or secondary. Four out of five cases definitely originated within the bone.

  5. Postirradiation malignant fibrous histiocytoma of the trachea

    International Nuclear Information System (INIS)

    A 77-yr-old woman presented with a malignant fibrous histiocytoma (MFH) of the trachea 11 yr after right subtotal thyroidectomy and delivery of 5400 rads to the neck for infiltrating papillary thyroid carcinoma. The tumor developed in the irradiated area. Postirradiation MFH tends to occur in subcutaneous tissues, and is rare in lung parenchyma or airways

  6. [Malignant fibrous histiocytoma of the lung].

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    Stolze, T; Quednow, C; Nicolai, D; Liebetrau, G

    1995-05-01

    The malignant fibrous histiocytoma of the lung is one of the rarely diagnosed soft tissue sarcomas. With the presented case-history we want to remind of this kind of lung-tumour in particular of the possibility of pre-operative diagnostic and the radiological differential diagnosis. PMID:7610106

  7. Postirradiation sarcoma (malignant fibrous histiocytoma) of axilla

    International Nuclear Information System (INIS)

    A case is reported of a patient who developed a histologically unusual sarcoma in the axilla and chest wall 8 years after receiving radiation therapy (6500 rad) for carcinoma of the breast. This sarcoma showed light- and electron-microscopic features of a malignant fibrous histiocytoma, a tumor not documented among 24 previously reported cases of postirradiation sarcoma following the diagnosis of breast carcinoma. In addition, the literature is reviewed and discussed regarding postirradiation sarcoma in general following breast carcinoma

  8. Malignant fibrous histiocytoma of the orbit

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    Betharia S

    1988-01-01

    Full Text Available Two cases of malignant fibrous histiocytoma of the orbit are reported. Histopathological examination of the orbital biopsy specimen obtained after orbitotomy in one case and exenteration in another showed pleomorphic neoplastic cells arranged in storiform pattern. The tumour cells were composed of hyperchromatic nuclei with prominent nucleoli and admixtures of fibrob-lasts. Postoperative radiotherapy and chemotherapy were given. There was no evidence of recurrence two years later.

  9. Postirradiation sarcoma (malignant fibrous histiocytoma) following cervix cancer

    International Nuclear Information System (INIS)

    A case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 11 years following postoperative external beam radiation therapy (7000 rad) for carcinoma of the cervix. Reports of postirradiation malignant fibrous histiocytoma are rare, and the occurrence of this neoplasm following treatment of cervix cancer has not previously been described. The literature concerning postirradiation bone and soft tissue sarcomas is briefly reviewed, with special attention to malignant fibrous histiocytomas

  10. Postirradiation sarcoma (malignant fibrous histiocytoma) following cervix cancer

    International Nuclear Information System (INIS)

    A case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 11 years following postoperative external beam radiation therapy (7,000 rad) for carcinoma of the cervix. Reports of postirradiation malignant fibrous histiocytoma are rare, and the occurrence of this neoplasm following treatment for cervix cancer has not previously been described. The literature concerning postirradiation bone and soft tissue sarcomas is briefly reviewed, with special attention to malignant fibrous histiocytomas. (author)

  11. Imaging of soft tissue malignant fibrous histiocytoma

    International Nuclear Information System (INIS)

    Malignant fibrous histiocytoma (MFH) is a rare and potentially highly malignant sarcoma. The authors report 6 cases of MFH in various sites : two in the chest wall, one in the pelvis, two in the gluteal zones and one on the scalp. Ultrasonography and computed tomography were the main imaging methods used in the assessment of the structure and extension of the tumor. A poor prognosis was noted in four cases: death within a few months in the two thoracic sites, recurrence in the pelvic and scalp lesions, radical surgery allowed recovery in two cases. A review of the literature showed that MRI and CT are complementary in the initial staging and follow-up these patients. (author)

  12. A postirradiation, myxoid type, malignant fibrous histiocytoma

    International Nuclear Information System (INIS)

    The authors discuss the case of a 59-year-old man who presented a mass in the dorsum of his right foot. He previously had had a hemangioma in this region from birth, and at the age of 10, radiation therapy had been administered to this region because of an ulcer that had developed. Additionally, so as to cover the ulcer, he had been given a free skin graft and a cross-leg flap. Some 50 years after this radiation, he noticed a mass in his foot, and a microscopic examination of a biopsied specimen of this mass revealed it to be a myxoid type, malignant fibrous histiocytoma (MFH). Thus, a below-the-knee amputation was performed. To the best of their knowledge, the authors report that 29 cases of an MFH developing after radiotherapy have been reported in the Japanese literature, and an analysis of these 29 cases is provided and the details of this case are given. (author)

  13. Malignant fibrous histiocytoma of colon: a case report

    International Nuclear Information System (INIS)

    Gastrointestinal malignant fibrous histiocytomas (MFH) are very rare and only about 30 cases have been reported in the English literature, among which 20 cases were from colorectal MFHs. A small bowel MFH with intussusception has been the only reported case in the Korean medical literature. A 52-year-old male presented with complaints of recently developed and aggravated right upper abdominal pain. We present the CT appearance and the clinico-pathologic findings of his primary inflammatory malignant fibrous histiocytoma, which arose from the subserosal layer of the ascending colon with tumor infiltration in all the layers. The colon showed extensive hemorrhagic necrosis and repetitive multifocal microperforations with resultant panperitonitis

  14. Retroperitoneal malignant fibrous histiocytoma: radiological aspects - a case report

    International Nuclear Information System (INIS)

    The authors present a retroperitoneal malignant fibrous histiocytoma case report that, although considered the most common soft tissue sarcoma in middle-aged adults, still represents a difficult diagnosis, rising a lot of doubt. It is emphasized the importance of computer tomography and magnetic resonance imaging in correlation with pathological aspects. (author). 6 refs, 7 figs

  15. FDG PET/CT Findings of Malignant Fibrous Histiocytoma of the Stomach.

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    Zheng, Wanwei; Chen, Jian; Liu, Jie; Zuo, Chuantao; Zhou, Zhongwen

    2015-05-01

    A 22-year-old man underwent an FDG PET/CT scan to evaluate possible malignancy due to melena and fever for 1 month. The images demonstrated intense FDG activity with an SUVmax of 24.6 in a large mass in the fundus of the stomach. Gastric malignant fibrous histiocytoma was histopathologically confirmed. Malignant fibrous histiocytoma is a high-grade and aggressive sarcoma, which usually occurs in the limbs or retroperitoneum. Malignant fibrous histiocytoma in the stomach is rare. PMID:25347349

  16. A case of primary malignant fibrous histiocytoma of the duodenum

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    Makni, Amin; Chebbi, Faouzi; Azzouz, Haifa; Magherbi, Houcine; Jouini, Mohamed; Kacem, Montassar; Safta, Zoubeir Ben

    2011-01-01

    Background Primary malignant fibrous histiocytoma (MFH) of the duodenum is rare and a distinct clinical entity. Case report A 55-year-old man presented with a history of upper gastrointestinal bleeding, vomiting and decreased body weight over the past 2 months. Abdominal exam showed an epigastric mass of 10 cm. An upper gastrointestinal endoscopy documented a tumor in the third part of duodenum. The histopathological examination of biopsy has concluded a MFH. Abdominal CT revealed a large and heterogeneous mass of 10 cm in the third part of the duodenum. The intervention was conducted by way of a bi-subcostal laparotomy. Exploration of the tumor revealed involvement of the third part of duodenum. This lesion adhered and invaded the inferior vena cava. A palliative procedure using a gastro-entero-anastomosis was carried out with uneventful postoperative course. Neither adjuvant chemotherapy nor radiotherapy were conducted. The patient died four months following his operation. Conclusion The biological behavior of malignat fibrous histiocytomas is extremely aggressive and mainly conditioned by size and histological grading. The treatment of choice, whenever possible, is based on early and complete surgical excision of the tumor. PMID:22096696

  17. Radiosensitivity of an isolated human malignant fibrous histiocytoma cell line

    International Nuclear Information System (INIS)

    A human cell line (YU-137) isolated from a bone of malignant fibrous histiocytoma in bone was evaluated using immunofluorescent staining methods. Cell cycle fractions were studied by flow cytometry. The magnitude of G2+M fraction in a cell cycle of an exponentially growing population of YU-137 was higher than that observed in HeLa S3 cells. The doubling time of YU-137 cells was 3.2 days. The radiosensitivity of this cell line was compared with HeLa S3 and HMV-1 cells from dose response curves against X-irradiation. The parameters of radiosensitivity of YU-137 against X-irradiation were n=2.0, D0=1.05 Gy and D0=0.73 Gy. From these data, the radiosensitivity of YU-137 was discussed. (author)

  18. MALIGNANT FIBROUS HISTIOCYTOMA OF THE PENIS A CASE REPORT AND REVIEW OF THE LITERATURE

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    Tufan Tarcan

    2009-01-01

    Full Text Available Penile malignant fibrous histiocytoma is an extremely rare tumor. To the best of our knowledge, we present here the fifth primary malignant fibrous histiocytoma of the penis. The patient presented with lung metastasis which initially responded well to systemic chemotherapy with Adriamycin and Ifosfamide, but recurred soon after. The local lesion did not respond to chemotherapy and the patient had to undergo a palliative penectomy. The disease progressed rapidly and the patient died one year after the diagnosis.

  19. Histiocitoma fibroso maligno / Histiocytome fibreux malin / Malignant fibrous histiocytoma

    Scientific Electronic Library Online (English)

    Hiralio, Collazo Álvarez; Dewar, Torrecilla Silverio; Jorge Luis, Morales Florat; Stephens Yecc, Collazo Marín.

    2012-06-01

    Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: los sarcomas son tumores malignos de partes blandas que representan 0,7 % de los tumores malignos en general, con una tasa de 3 por cada 100 000. El histiocitoma fibroso maligno resulta un tumor de alto grado incluido en el grupo de los sarcomas de partes blandas. Objetivo: exponer las [...] características citohistológicas, el tratamiento y la evolución de este tumor en un caso estudiado y tratado en el Hospital General Provincial Docente "Roberto Rodríguez Fernández" de Ciego de Ávila. Descripción: se presentó el caso de un varón de 60 años con una gran masa de partes blandas en el muslo izquierdo, de crecimiento progresivo. La masa se trató quirúrgicamente con exéresis en bloque, previos estudios analíticos, arteriografía femoral y ecografía. Conclusiones: el diagnóstico anatomopatológico fue de histiocitoma fibroso maligno variedad pleomórfica; fue remitido al servicio de oncología donde lo trataron con radioterapia. A los 6 meses se encontraba libre de la enfermedad. Se realizó una revisión de la literatura y se analizó su presentación clínica, también los hallazgos histológicos, las pruebas diagnósticas de imagen y el procedimiento terapéutico. Abstract in english Introduction: the sarcomas are soft tissue malignant tumors accounting for the 0.7 % of malignant tumors in general with a rate of 3 by 100 000. The malignant fibrous histiocytoma is a high grade tumor included in the group of soft tissue tumors. Objective: to expose the cytohistologic features, tre [...] atment and course of this tumor in study case and treated in "Roberto Rodríguez Fernández" Teaching Provincial Hospital of Ciego de Avila municipality. Description: this is the case of a male patient aged 60 presenting with an increasing large soft tissue mass in the left thigh. The mass was operated on with block exeresis, analytical previous studies, femoral arteriography and echography. Conclusions: the anatomic and pathologic diagnosis was a malignant fibrous histiocytoma pleomorphous type; the patient was referred to Oncology service where was treated with radiotherapy. At 6 months he was free of disease. A review of literature was performed analyzing its clinical presentation also, its histological findings, the imaging diagnostic test and the therapeutical procedure.

  20. Postirradiation sarcoma (malignant fibrous histiocytoma) following uterine cervical cancer

    International Nuclear Information System (INIS)

    A case of postirradiation sarcoma, a malignant fibrous histiocytoma, is described. The tumor occurred in the radiation field (the buttock) 8 years after radiation therapy for keratinizing squamous cell carcinoma of the uterine cervix. The 68-year-old female patient with the inital diagnosis of cervical cancer was treated with pelvic irradiation in 1973. She did well after that with no evidence of disease until 1981 when she developed an enlarging mass in the right buttock within the field of the previous radiation therapy. Microscopically, the tumor at biopsy was composed of pleomorphic histiocyte-like cells, spindle-sphaped cells arranged in a storiform pattern and multinucleated giant cells with bizarre nuclei. Cytodiagnostically, two types of cells, fibroblast-like cells ane histiocyte-like cells, were found. And some cells were considered to be transitional forms, intermediate between fibroblast and histiocytes. Multinucleated pleomorphic giant cells were sometimes seen. Ultrastructurally, the same types of cells were confirmed. These cells contained large numbers of rough endoplasmic reticula with dilated lumens, vacuoles, lysosomal structures, and lipid droplets. (author)

  1. Urachal malignant fibrous histiocytoma: a case report and review of the literature.

    Science.gov (United States)

    Wang, Beverly Y; Boag, Alexander H; Idrees, Muhammad; Young, Iain D; Unger, Pamela D

    2004-04-01

    Pathologic processes involving the urachus are usually related to inflammatory or sinofistular conditions. Neoplasms rarely arise within this structure, and when they do occur, they are typically epithelial, with mucinous adenocarcinoma being the most common. Mesenchymal lesions, both benign and malignant, have rarely been described in this location. We report the case of a 66-year-old white man who presented with a primary urachal malignant fibrous histiocytoma and died of metastatic disease 20 months after the initial diagnosis. This is an unusual case of malignant fibrous histiocytoma arising in a urachal remnant. PMID:15043458

  2. Primary malignant fibrous histiocytoma of the chest wall misdiagnosed as traumatic hemothorax.

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    Hwang, Ki-Eun; Hwang, June-Seong; Kim, Kyung-Min; Jung, Jae-Wan; Oh, Su-Jin; Kim, Eun-Kyoung; Ryu, Dae-Woon; Choi, Keum-Ha; Jeong, Eun-Taik; Kim, Hak-Ryul

    2014-06-01

    Malignant fibrous histiocytoma (MFH), a type of sarcoma, is a malignant neoplasm with uncertain origins that arise from both the soft tissues and the bone. The occurrence of MFH on the chest wall is extremely rare. We hereby report a case of a 72-year-old woman who was incidentally detected with MFH after a traffic accident. PMID:25024723

  3. Primary Malignant Fibrous Histiocytoma of the Chest Wall Misdiagnosed as Traumatic Hemothorax

    OpenAIRE

    Hwang, Ki-eun; Hwang, June-seong; Kim, Kyung-min; Jung, Jae-wan; Oh, Su-jin; Kim, Eun-kyoung; Ryu, Dae-woon; Choi, Keum-ha; Jeong, Eun-taik; Kim, Hak-ryul

    2014-01-01

    Malignant fibrous histiocytoma (MFH), a type of sarcoma, is a malignant neoplasm with uncertain origins that arise from both the soft tissues and the bone. The occurrence of MFH on the chest wall is extremely rare. We hereby report a case of a 72-year-old woman who was incidentally detected with MFH after a traffic accident.

  4. Malignant fibrous histiocytoma developed in the chest wall following irradiation treatment for breast cancer

    International Nuclear Information System (INIS)

    An autopsy case of malignant fibrous histiocytoma of the chest wall occurring in a 67-year-old female was reported. She had a history of radical mastectomy and postoperative irradiation for breast cancer. 19 years later, she developed malignant fibrous histiocytoma in the chest wall. The post-mortem examination revealed a tumor in the chest wall invading the anterior mediastinum and metastasizing to the apex of the left lung. The irradiation was implicated in the cause of the tumor in this patient. (author)

  5. Thallium 201 and Gallium 67 uptake in malignant fibrous histiocytoma of the heart

    International Nuclear Information System (INIS)

    A patient with malignant fibrous histiocytoma of the heart is described who was initially presented with a left atrial tumor. Subsequent 201Tl and 67Ga scintigraphy showed massive uptake of the tracers by the tumor and the pattern of uptake was thought to reflect underlying necrosis and hemorrhage within the tumor

  6. Simultaneous squamous cell carcinoma with primary malignant fibrous histiocytoma of the larynx: A case report

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    Cao, Xiaolin; Liu, Jun; Zheng, Youyang; Li, Qiaoyun; Teng, Yaoshu; Li, Yong

    2012-01-01

    Simultaneous multiple malignancies of the larynx are rarely reported. In this study, we describe a case with simultaneous laryngeal, moderately differentiated squamous cell carcinoma (SCC) and primary malignant fibrous histiocytoma (MFH) in a patient presenting with progressive hoarseness and without cervical lymphadenopathy. The clinical presentation, intraoperative findings, radiographic images and pathology slides are presented. The diagnosis was confirmed using H&E staining and immunohist...

  7. [A rare cardiac tumor: the malignant fibrous histiocytoma. Description of a case].

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    Talamonti, Ennio; Patrizi, Giampiero; Gabrieli, Luca; Gamboni, Alessandro; Cimato, Paolo; Ricci, Silvio

    2004-08-01

    The present report describes the case of a 61-year-old woman with malignant fibrous histiocytoma of the left atrium originating from the left atrial free wall, operated on in emergency for a suspected large left atrial myxoma that, at the echo scan, was consistently protruding through the left atrioventricular orifice at each diastole and was almost completely occluding the left ventricular inflow, causing signs of congestive heart failure and severe dyspnea. Surgery was performed as radically as possible, but the histological examination of the specimen revealed the exact diagnosis of the neoplasm. About 75% of primary tumors are benign and 75% of these are atrial myxomas. The malignant tumors consist of various sarcomas: myxosarcoma, liposarcoma, angiosarcoma, fibrosarcoma, leiomyosarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, undifferentiated sarcoma, reticulum cell sarcoma, neurofibrosarcoma, and malignant fibrous histiocytoma. The long-term results for sarcomas are very poor and there are few survivors after several months from surgery due to the extent of local spread and invasion or because of the frequent distant metastases. Malignant fibrous histiocytoma constitutes about 2% of all cardiac malignancies, which might grow within several localized areas, occasionally in the heart. Echocardiography represents the best examination procedure for both diagnosis and follow-up of patients with cardiac tumors. PMID:15554023

  8. Primary Giant Cell Malignant Fibrous Histiocytoma of the Kidney with Staghorn Calculi

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    Chen C

    2003-01-01

    Full Text Available Malignant fibrous histiocytomas (MFH as primary renal tumours are rare, with less than 50 cases described in the literature. We report a case of primary renal MFH of giant cell type in a 56-year-old man, who presented with bilateral dull flank pain, intermittent gross haematuria and body weight loss (6 kg in 3 months. Intravenous urography, computerized tomography (CT and magnetic resonance image (MRI showed right ureteral stones with mild hydronephrosis, and a solid mass at the lower pole of the left kidney associated with staghorn calculi, as well as tumour thrombi in the left renal vein and inferior vena cava. Left radical nephrectomy and evacuation of tumour thrombi from the left renal vein and inferior vena cava were performed. Histopathologic examination revealed malignant fibrous histiocytoma (MFH of giant cell type. To the best of our knowledge, this is the first report of primary renal MFH associated with staghorn calculi.

  9. Primary malignant fibrous histiocytoma of the renal pelvis: a 78-month follow-up case report

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    Chen YB

    2013-12-01

    Full Text Available YueBing Chen,1 Dapang Rao,2 Haibo Zhu,2 Haifeng Yu,2 ShiKun Yang21Department of Urology, Affiliated Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, 2Department of Urology, 2nd Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, People's Republic of ChinaAbstract: Primary malignant fibrous histiocytoma of the renal pelvis is extremely rare. This article reports a pathologically confirmed case. Surgery is the main treatment for this disease. Chemotherapy and radiotherapy have been reported to be ineffective. It is difficult to differentiate it from urothelial tumor of the renal pelvis and renal cell carcinoma by preoperative laboratory and radiological evaluation. Immunohistochemical study is helpful in confirming the diagnosis of the disease. This report discusses the clinical manifestations, pathohistological characteristics, treatment, and prognosis of the case reported.Keywords: primary malignant fibrous histiocytoma, tumor, urothelium, and renal cell carcinoma

  10. Primary Malignant Fibrous Histiocytoma of the Kidney: Report of a Case

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    Nilay ?EN TÜRK

    2010-05-01

    Full Text Available Primary renal malignant fibrous histiocytoma is extremely rare. The prognosis is generally poor because of the high rate of local recurrence even if radical surgery is performed. We report a case of primary renal malignant fibrous histiocytoma in a 43-year-old woman.A well-defined renal mass (10x9x7cm with lobulated contour was revealed by abdominal ultrasonography and computerized tomography in our patient who presented with left-flank pain. The contralateral kidney and renal functions were normal. No other primary tumor focus was detected by screening performed to exclude a metastasis to the kidney. However, a nodule consistent with metastasis was identified in the liver. The patient underwent left radical nephrectomy. A huge, yellowish-white, partly necrotic neoplasm infiltrating the renal parenchyma, perirenal fat and adrenal tissue was revealed by gross examination. Microscopically, the tumor was composed of pleomorphic spindle to polygonal cells arranged in fascicles and storiform structures with extensive necrosis. Twelve mitotic figures were noted in 10 high power fields. Immunohistochemical staining for vimentin and CD68 were positive whereas pan-cytokeratin, smooth muscle actin, S-100, HMB-45 and desmin were negative. “A pleomorphic type of malignant fibrous histiocytoma” was diagnosed based on both the microscopic and immunohistochemical findings. The patient presented with multiple bilateral lung metastasis three years after nephrectomy.Histopathological examination is essential since malignant fibrous histiocytoma cannot be differentiated clinically and radiologically from other lesions with kidney involvement. The overall prognosis is unfavorable with a recurrence rate of more than 50% and the 5-yearsurvival rate is only 14%.

  11. Primary Giant Cell Malignant Fibrous Histiocytoma of the Kidney with Staghorn Calculi

    OpenAIRE

    Chen C; Lee P; Han W; Shen K

    2003-01-01

    Malignant fibrous histiocytomas (MFH) as primary renal tumours are rare, with less than 50 cases described in the literature. We report a case of primary renal MFH of giant cell type in a 56-year-old man, who presented with bilateral dull flank pain, intermittent gross haematuria and body weight loss (6 kg in 3 months). Intravenous urography, computerized tomography (CT) and magnetic resonance image (MRI) showed right ureteral stones with mild hydronephrosis, and a solid mass at the lower pol...

  12. MRI of malignant fibrous histiocytoma of soft tissue: analysis of 13 cases with pathologic correlation

    International Nuclear Information System (INIS)

    We reviewed the magnetic resonance (MR) appearances of 13 malignant fibrous histiocytomas (MFH) of soft tissue and correlated each with the respective lesion's histopathology. The MR images were evaluated for signal intensity on T1- and T2-weighted spin echo sequences, homogeneity of the lesion, presence of internal low signal septations, and margin definition. Histologic subtypes of MFH included storiform-pleomorphic, giant cell, myxoid, and inflammatory. We could not establish a correlation between MR appearance and histopathology. Instead, our series exhibited general features suggestive of malignant soft tissue neoplasms, namely poor margin definition, internal low signal septation, and heterogeneous high signal intensity on T2-weighted images. (orig.)

  13. MRI of malignant fibrous histiocytoma of soft tissue: analysis of 13 cases with pathologic correlation

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    Miller, T.T. (Dept. of Radiology, Mount Sinai Medical Center of the City Univ. of New York, NY (United States)); Hermann, G. (Dept. of Radiology, Mount Sinai Medical Center of the City Univ. of New York, NY (United States)); Abdelwahab, I.F. (Dept. of Radiology, Mount Sinai Medical Center of the City Univ. of New York, NY (United States)); Klein, M.J. (Dept. of Pathology, Mount Sinai Medical Center of the City Univ. of New York, NY (United States)); Kenan, S. (Dept. of Orthopedic Surgery, Mount Sinai Medical Center of the City Univ. of New York, NY (United States)); Lewis, M.M. (Dept. of Orthopedic Surgery, Mount Sinai Medical Center of the City Univ. of New York, NY (United States))

    1994-05-01

    We reviewed the magnetic resonance (MR) appearances of 13 malignant fibrous histiocytomas (MFH) of soft tissue and correlated each with the respective lesion's histopathology. The MR images were evaluated for signal intensity on T1- and T2-weighted spin echo sequences, homogeneity of the lesion, presence of internal low signal septations, and margin definition. Histologic subtypes of MFH included storiform-pleomorphic, giant cell, myxoid, and inflammatory. We could not establish a correlation between MR appearance and histopathology. Instead, our series exhibited general features suggestive of malignant soft tissue neoplasms, namely poor margin definition, internal low signal septation, and heterogeneous high signal intensity on T2-weighted images. (orig.)

  14. Bone and gallium scan findings in malignant fibrous histiocytoma. Case report with radiographic and pathologic correlation

    International Nuclear Information System (INIS)

    Malignant fibrous histiocytoma (MFH) is the most common soft tissue malignancy in adults. The Ga-67 citrate scan findings of an extremity-located MFH, the most common location of this neoplasm, have never been published in English language journals to the best of the authors' knowledge. Ga-67 citrate and Tc-99m MDP scans of the thigh mass accurately depicted the tumor's local extent, including the presence of central ischemic necrosis within the tumor, and the absence of adjacent osseous involvement and distant metastases, as correlated with computed tomography, angiography, and pathologic examinations

  15. Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature

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    Yao Dianbo

    2012-01-01

    Full Text Available Abstract Background A malignant fibrous histiocytoma is a soft tissue tumor that most commonly occurs in the extremities, but rarely involves the liver. The clinical characteristics and therapeutic experiences of primary hepatic malignant fibrous histiocytoma are still limited. Methods Two cases of primary hepatic malignant fibrous histiocytoma were analyzed retrospectively, and all the literature concerning primary hepatic malignant fibrous histiocytoma was analyzed. Results In China, a total of 76 cases had been reported, among which 50 were men, with a male to female ratio of 1.9:1. Mean age of the patients was 51.0 years old, and more than 85 percent were older than 40 years. 82.9 percent (63/76 of hepatic MFH were solitary lesions, with tumor size ranging from 2.5 to 23.5 cm (average 10.3 cm. Major clinical presentation (78.4% was abdominal pain or discomfort, accompanied with some other non-specific symptoms such as malaise, anorexia, weight loss, jaundice and fever, and small cases (14.9% were asymptomatic. Computed tomography and ultrasound usually revealed the location of lesions. The rate of pre-operative misdiagnosis was extremely high, and 14.9 percent of patients were even misdiagnosed as a benign liver cyst, liver abscess or hematoma. Integrated resection was performed among the most cases (49/68, among which only a few ones (12 cases were introduced to have no recurrence or metastasis or be still alive with no detail information provided, while among the cases with palliative operation or only a biopsy, the cases that were followed-up all died. Conclusions Hepatic malignant fibrous histiocytoma is a rare malignant mesenchymal tumor. The variable features of clinical presentations and images make the diagnosis difficult. Though the prognosis of primary hepatic malignant fibrous histiocytoma was rather poor, integrated resection might provide a few cases a good opportunity for surviving, suggesting that surgery might be an effective treatment.

  16. Myxoid Type of Malignant Fibrous Histiocytoma of the Maxillary Sinus: A Case Report

    OpenAIRE

    Amir Hossein Jafarian; Abbas Ali Omidi; Mohammad Mehdi Ghasemi; Bahareh Joushan

    2011-01-01

    Introduction: Myxofibrosarcoma was originally described as the myxoid variant of Malignant Fibrous Histiocytoma (MFH), a high-grade and aggressive sarcoma, which is very uncommon in the head and neck region, with about 100 cases reported up to now. MFH occurring in the maxillary sinus is so rare that only 23 cases have been reported. We hereby report a case of myxofibrosarcoma in the maxillary sinus. Case Report: The case was a 54-year-old male with symptoms of toothache in the right posterio...

  17. A case of malignant fibrous histiocytoma of the pancreas: computed tomography (CT) and ultrasound (US) appearance

    International Nuclear Information System (INIS)

    The case of a 50-year-old female with a malignant fibrous histiocytoma of the pancreas is presented. This was diagnosed pre-operatively on ultrasound and computed tomography (CT). The lesion encircled the body and tail of the pancreas and appeared as a large inhomogeneous mass with polycyclic and well-defined margins. Contrast-enhanced CT examination showed marked but inhomogeneous enhancement. The tomodensitometric characteristics plus the lack of lymphnodal or hepatic metastases indicated the sarcomatous nature of the mass before the surgical approach. (orig.)

  18. Malignant fibrous histiocytoma of the scalp: A rare differential with a dramatic clinical presentation

    OpenAIRE

    Krishnamurthy, Arvind

    2014-01-01

    Malignant fibrous histiocytoma (MFH) a pleomorphic sarcoma of uncertain origin was first described by O’Brien and Stout in 1964. It is the most common primary soft tissue sarcoma of late adult life; its occurrence is rare in the pediatric population. MFHs are commonly known to arise in the extremities and the trunk although it can occur almost anywhere in the body. MFH of the scalp is extremely rare; moreover, there is paucity of literature with regards to prevalence of scalp and skull neop...

  19. Global protein-expression profiling for reclassification of malignant fibrous histiocytoma.

    Science.gov (United States)

    Kikuta, Kazutaka; Morioka, Hideo; Kawai, Akira; Kondo, Tadashi

    2014-08-28

    According to the newest World Health Organization (WHO) classification for soft tissue tumors in 2013, malignant fibrous histiocytoma (MFH) has been gone. Most sarcomas called MFH were reclassified to be high-grade pleomorphic forms of leiomyosarcoma, liposarcoma, rhabdomyosarcoma, and other sarcomas by recent molecular technologies. However, about 10% to 15% of sarcomas called MFH before, still cannot be given a precise classification, and these are now called undifferentiated pleomorphic sarcoma or are still called MFH. Further molecular approaches including proteomic approaches are imperative to classify these unclassified sarcomas for improving clinical outcomes of the patients with soft tissue sarcomas. This article is part of a Special Issue entitled: Medical Proteomics. PMID:25173742

  20. Post-radiation malignant fibrous histiocytoma following treatment of breast cancer: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Min, Jun Won; Lee, Won Ae; Kim, You Me [Dankook University College of Medicine, Seoul (Korea, Republic of)

    2013-10-15

    Post-radiation malignant fibrous histiocytoma (MFH) of the breast is extremely rare. We report a case of post-radiation MFH that presented a rapidly growing mass in a 52-year-old woman who underwent breast-conserving therapy and adjuvant whole breast irradiation 6 years ago. To the best of our knowledge, only one case of primary MFH of the female breast have been reported with sonographic findings. We analyzed the sonographic and MRI findings with correlative histopathologic features, and then confirmed with surgical excision.

  1. An 11 kg Malignant Fibrous Histiocytoma in a 54-Year-Old Patient: A Case Report

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    Ghadir M.R

    2011-08-01

    Full Text Available Background and Objectives: Malignant fibrous histiocytoma (MFH is a soft tissue sarcoma of undifferentiated mesenchymal cell origin which is considered the most common soft tissue sarcoma in adults. It commonly occurs in the 5th and 6th decades with a 2-to-1 male to female ratio. It most frequently occurs in the extremities and retroperitoneum. Most of it is derived from soft tissues and some of it from bone tissue. In this study, we introduce a patient who had MFH in retroperitoneal area and at the time of diagnosis the tumor size and weight had reached a significant level.Case Report: The patient is a 54-year-old male that referred to the hospital with complaints of pain and fullness in the abdomen. His pain had started from two years ago and had been accompanied with early satiation, bloating, weight gain and hypertension. On physical examination, asymmetric enhancement was visible. After diagnosis of mass and investigation of its development in abdomen and pelvic with CTscan, the patient was underwent operation and a mass with about 11kg of weigh was resected. During pathologic investigation, high grade spindle cell sarcoma and malignant fibrous histiocytoma were reported. After resection of tumor, the abdominal pain of patient disappeared and additionally his blood pressure came back to normal levels.

  2. Primary malignant fibrous histiocytoma of the breast: report of one case

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    Liu C

    2013-04-01

    Full Text Available Caigang Liu,1 Zuowei Zhao,1 Qingfu Zhang,2 Yunfei Wu,3 Feng Jin3 1Department of Breast Surgery, Second Hospital of Dalian Medical University, Dalian, People's Republic of China; 2Department of Pathology, First Hospital of China Medical University, Shenyang, People's Republic of China; 3Department of Breast Surgery, General Surgery, First Hospital of China Medical University, Shenyang, People's Republic of China. Abstract: Seven years ago, a 48-year-old female patient discovered a painless tumor in her right breast simply by chance. In the next year, the tumor increased significantly in size. At this point, the patient received a tumor resection, which was misdiagnosed as a benign mesenchymal tissue-originated tumor. Unfortunately, the tumor recurred just 10 days after resection. We subsequently resected the recurrent lesion and confirmed primary breast malignant fibrous histiocytoma. The tumor began to exhibit an unprecedented, massive, and uncontrolled growth, ulcerating soon after the operation. Treatment of the patient was limited by time. After the patient received a cycle of chemotherapy, she died of cachexia with the emergence of multiorgan metastasis 2 months after the operation. Keywords: breast, primary malignant fibrous histiocytoma, treatment, survival

  3. A malignant fibrous histiocytoma after radical mastectomy with radiotherapy. A case report

    International Nuclear Information System (INIS)

    A rare case of radiation induced malignant fibrous histiocytoma is presented. A 57-year-old woman noticed a rapidly enlarging tumor with itch in the left supraclavicular region and visited another hospital. There was a previous history of undergoing a radical mastectomy with radiotherapy for a left breast cancer at elsewhere (no clear information on clinical stage and dose of radiation was obtained). The patient was referred to the hospital. On admission a 10 x 8 cm tumor in the left supraclavicular region was noted. The tumor had lobulated surface to bleed easily and fixed to the clavicle. Thoracic CT and MRI revealed a hypervascular tumor destroying the clavicle. Angiography showed keterogenous vascularity of the tumor vis the transverse and ascending cervical arteries. We carried out wide resection of the tumor with the clavicle and reconstructed with a left lattisimus dorsi flap. Since the tumor was composed of atypical fibroblasts and histiocytes. It was diagnosed as radiation induced malignant fibrous histiocytoma. After operation, inflammation of the flap and dyskinesia of the left upper extremity occurred, but were managed conservatively. There has been no sign of recurrence as of 2 years and 8 months after the operation. (author)

  4. Report of a Rare Case of Malignant Fibrous Histiocytoma of Mandible

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    Fatemeh Ahmadi-Motamayel

    Full Text Available Introduction: Malignent Fibrous Histiocytoma (MFH is the most frequent soft tissue sarcoma of adulthood. The most common sites affected by MFH are limbs, orbit, retroperitoneum, pelvis and knee. Oral cavity and mandible involvements are very rare. Case Report: A 35-year-old male was visited in the oral medicine department of Hamadan dental school with the chief complaint of pain and teeth mobility. The patient also had a history of paresthesia in lower lip for two monthes. In intraoral examination, there was a crater like, deep and disseminated ulcer in lower buccal and ligual gingiva of right mandibular teeth and exophitic lesion with smooth surface, and color similar to normal mucosa with 2×2×3 cm in diameter in buccal and lingual part of right lateral and central teeth extended to left second premolar was observed. Gingival resorption was observed in all adjascent teeth. There was radiolucency with irregular border in all part of lesion. MFH was confirmed by histopathological report.Conclusion: The most common complaint of patients with malignant fibrous histiocytoma is the growing mass that could be ulcerative or painful. Early diagnosis and referral is very important in prognosis and survival of the patients.

  5. Myxoid Type of Malignant Fibrous Histiocytoma of the Maxillary Sinus: A Case Report

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    Amir Hossein Jafarian

    2011-04-01

    Full Text Available Introduction: Myxofibrosarcoma was originally described as the myxoid variant of Malignant Fibrous Histiocytoma (MFH, a high-grade and aggressive sarcoma, which is very uncommon in the head and neck region, with about 100 cases reported up to now. MFH occurring in the maxillary sinus is so rare that only 23 cases have been reported. We hereby report a case of myxofibrosarcoma in the maxillary sinus. Case Report: The case was a 54-year-old male with symptoms of toothache in the right posterior maxillary teeth, a swelling adjacent to maxillary molar region and symptoms of chronic maxillary sinusitis. In clinical examination, the teeth were sensitive to percussion and palpation, but no caries and restoration was detected on his molar teeth. He was suffering from local pain and tenderness over his midface and mild fever, fatigue and some nonspecific vague pain. CT scan showed a mass lesion involving right nasal cavity, maxillary and ethmoidal sinuses. A low-grade malignancy arising from the right maxillary sinus was highly suspected. A surgery was done to remove the mass. The histological and immunohistochemical studies proved the diagnosis of myxoid variant of Malignant Fibrous Histiocytoma. Therefore radiotherapy and chemotherapy was started for the patient but six months later the symptoms returned and CT scan showed a right maxillary and ethmoidal mass that extended to base of the skull. Maxillectomy and ethmoidectomy were performed for the patient, but 2 months later he died because of the extension of the tumor, which confirmed the necessity of early diagnosis. Conclusion: Amplified radical surgery is the first choice of treatment. The second surgery has special value to the recurrent patients. Radiotherapy alone or chemotherapy alone is not effective to MFH of head and neck region

  6. Malignant fibrous histiocytoma of the breast. A case report and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Langham, M.R. Jr.; Mills, A.S.; DeMay, R.M.; O' Dowd, G.J.; Grathwohl, M.A.; Horsley, J.S.

    1984-08-01

    The clinicopathologic features of a malignant fibrous histiocytoma arising in a female breast are presented. Seven cases have been previously reported. These may be divided into three subgroups based on history and pathologic findings. Three of the seven occurred in women without a history of other tumors or previous irradiation. One appeared with a cystosarcoma phyllodes, and three arose following radiation for carcinoma of the breast. The patient in this study had received no radiation. Treatment has been based on surgical resection; the roles of chemotherapy and radiation are uncertain. Although resection alone in the first subgroup has lead to no reported mortality, the small number of cases and the relatively short follow-up does not allow a meaningful assessment of the prognosis in this disease.

  7. Primary pulmonary malignant fibrous histiocytoma mimics pulmonary artery aneurysm with partial thrombosis: various radiologic evaluations

    International Nuclear Information System (INIS)

    Primary pulmonary malignant fibrous histiocytoma (MFH) is very rare, so only a few imaging features have been reported. We report one case of rapidly growing primary pulmonary MFH mimicking a partially thrombosed pulmonary artery aneurysm and its radiologic findings, including multidetector row computed tomography (MDCT), conventional angiography, and fluorodeoxyglucose-positron emission tomography CT ([18F] FDG-PET/CT). On multi-phasic MDCT, this mass mimicked a pulmonary artery aneurysm with partial thrombosis. However, pulmonary artery aneurysm was excluded and suggested as a hypervascular parenchymal mass by subsequent conventional angiography. On [18F] FDG-PET/CT, it was a highly metabolic mass, showing a maximal standard uptake value (SUV) 12.1. Although primary pulmonary MFH is very rare and has no specific imaging findings, our experience might be helpful to differentiate a hypervascular pulmonary mass. (orig.)

  8. Primary malignant fibrous histiocytoma in mediastinum: Imaging with {sup 18}F FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Bong Hoi [Gyeongsang National Univ. Hospital, Jinju (Korea, Republic of); Yoon, Seok Ho; Lee, Sung Soo; Jo, Kyung Sook; Song, Hee Sung; An, Young Sil; Yoon, Joon Kee; Lee, Su Jin [Ajou Univ. School of Medicine, Suwon (Korea, Republic of)

    2012-12-15

    Malignant fibrous histiocytoma (MFH) is the most common soft tumor which often occurs in the extremities and the retroperitoneum. Pimary mediastinal MFH is rare; thus, findings on {sup 18}F fluorodeoxyglucose positron emission tomography/computed tomography ({sup 18}F FDG PET/CT) of mediastinal MFH have not been reported yet. We report herein the case of a 64 year old man who was presented with a superior mediastinal mass. the mass showed intense {sup 18}F FDG uptake with central metabolic defect on PET/CT the maximum standardized uptake value was 17.4. after tumor removal via median sternotomy, an MFH of the storiform pleomorphic type was diagnosed on histopathologic examination. We the first report of {sup 18}F FDG PET/CT imaging of MFH in the superior mediastinum.

  9. Malignant fibrous histiocytoma of the scalp: A rare differential with a dramatic clinical presentation

    Science.gov (United States)

    Krishnamurthy, Arvind

    2014-01-01

    Malignant fibrous histiocytoma (MFH) a pleomorphic sarcoma of uncertain origin was first described by O’Brien and Stout in 1964. It is the most common primary soft tissue sarcoma of late adult life; its occurrence is rare in the pediatric population. MFHs are commonly known to arise in the extremities and the trunk although it can occur almost anywhere in the body. MFH of the scalp is extremely rare; moreover, there is paucity of literature with regards to prevalence of scalp and skull neoplasms. We present an unusual case of a primary MFH involving the scalp of a 5-year-old child and discuss its unusual clinical presentation, histology with immunohistochemistry correlation and its management. Reviewing the literature of primary MFH of the scalp, our patient to the best of our knowledge, is probably the youngest case reported so far. PMID:25336806

  10. Malignant fibrous histiocytoma of the breast. A case report and review of the literature

    International Nuclear Information System (INIS)

    The clinicopathologic features of a malignant fibrous histiocytoma arising in a female breast are presented. Seven cases have been previously reported. These may be divided into three subgroups based on history and pathologic findings. Three of the seven occurred in women without a history of other tumors or previous irradiation. One appeared with a cystosarcoma phyllodes, and three arose following radiation for carcinoma of the breast. The patient in this study had received no radiation. Treatment has been based on surgical resection; the roles of chemotherapy and radiation are uncertain. Although resection alone in the first subgroup has lead to no reported mortality, the small number of cases and the relatively short follow-up does not allow a meaningful assessment of the prognosis in this disease

  11. Primary pulmonary malignant fibrous histiocytoma mimics pulmonary artery aneurysm with partial thrombosis: various radiologic evaluations

    Energy Technology Data Exchange (ETDEWEB)

    Noh, Hyun Woo; Park, Kyung Joo; Sun, Joo Sung; Won, Je Hwan; Kwack, Kyu-Sung [Ajou University School of Medicine, Department of Radiology, Suwon (Korea); Choi, Ho [Ajou University School of Medicine, Department of Thoracic and Cardiovascular Surgery, Suwon (Korea); Lee, Kyi Beom [Ajou University School of Medicine, Department of Pathology, Suwon (Korea); Park, Joo Hun [Ajou University School of Medicine, Department of Pulmonary and Critical Care Medicine, Suwon (Korea)

    2008-08-15

    Primary pulmonary malignant fibrous histiocytoma (MFH) is very rare, so only a few imaging features have been reported. We report one case of rapidly growing primary pulmonary MFH mimicking a partially thrombosed pulmonary artery aneurysm and its radiologic findings, including multidetector row computed tomography (MDCT), conventional angiography, and fluorodeoxyglucose-positron emission tomography CT ([18F] FDG-PET/CT). On multi-phasic MDCT, this mass mimicked a pulmonary artery aneurysm with partial thrombosis. However, pulmonary artery aneurysm was excluded and suggested as a hypervascular parenchymal mass by subsequent conventional angiography. On [18F] FDG-PET/CT, it was a highly metabolic mass, showing a maximal standard uptake value (SUV) 12.1. Although primary pulmonary MFH is very rare and has no specific imaging findings, our experience might be helpful to differentiate a hypervascular pulmonary mass. (orig.)

  12. Immunohistochemical Loss of the DNA Mismatch Repair Proteins MSH2 and MSH6 in Malignant Fibrous Histiocytomas

    OpenAIRE

    Mef Nilbert; Henryk Domanski; Amp Xe Ns Amp Xc Kerman, M.; Annika Lindblom; Jacob Engellau; Annette Persson; Kajsa Ericson

    2004-01-01

    Purpose: Soft tissue sarcomas (STS) account for less than 1% of all malignancies and constitute a heterogeneous tumor entity in which malignant fibrous histiocytomas (MFH) represent one-third and are characterized by a lack of type-specific differentiation. A defective mismatch repair (MMR) system cause the familial cancer syndrome hereditary non-polyposis colorectal cancer (HNPCC), and since occasional MFH have been described in HNPCC patients we assessed the contribution of defe...

  13. Malignant fibrous histiocytoma of the urinary bladder as a post-radiation secondary cancer: a case report

    Directory of Open Access Journals (Sweden)

    Nimmanon Thirayost

    2011-11-01

    Full Text Available Abstract Introduction Malignant fibrous histiocytomas have been periodically reported as the primary tumor in various organs including the urinary bladder, and is the second most frequent sarcoma of the urinary tract in adults. This report discusses a case of the well established diagnosis of a malignant fibrous histiocytoma of the bladder occurring as a post-radiation cancer after the treatment of a cervical carcinoma. Our findings support those of many previous studies and make the view of the nature of the disease clearer. Case presentation We report the case of a 54-year-old Thai woman who had been treated with radiation therapy for cervical cancer, who presented to our facility with urinary incontinence. Initially, our patient was diagnosed as having a high-grade urothelial carcinoma. Subsequent radical surgery rendered the final pathological diagnosis, confirmed histologically and immunohistochemically as malignant fibrous histiocytoma, with clinical and pathological staging of T4b N0 M0. Adjuvant chemotherapy was provided for our patient. Conclusions This type of malignancy is very aggressive and easily misdiagnosed due to its rarity. Therefore, in a patient with a prior history of irradiation in the pelvic area, this should be considered as a differential diagnosis to ensure early correct diagnosis and treatment.

  14. Fibro-histiocitoma maligno de extremidade: relato de caso Malignant fibrous histiocytoma of the extremity: a case report

    OpenAIRE

    Roberta Cardoso de Siqueira; Márcio Lobo Jardim; Valdir Bandeira; Das Chagas Ferreira, Rosana Maria Ca?ssia X.; Luciano Tavares Montenegro; Patrícia Guimarães; Virgínia Batista

    2004-01-01

    Fibro-histiocitoma maligno é o sarcoma de tecidos moles mais encontrado em jovens. Raramente confina-se com exclusividade à pele e ao subcutâneo. O diagnóstico, na maioria das vezes, só é feito após excisão e estudo da peça cirúrgica. É agressivo, apresentando alto grau de recorrência local e metástases. Este artigo relata o caso de um paciente jovem com fibro-histiocitoma maligno de extremidade.Malignant fibrous histiocytoma is the most common soft tissue sarcoma found in young ...

  15. Primary dedifferentiated liposarcoma of the femur presenting with malignant fibrous histiocytoma: A case report and review of the literature

    OpenAIRE

    Zhang, Shuai; Wang, Xu-quan

    2014-01-01

    In the current report a case of a 26-year-old male with a primary dedifferentiated liposarcoma of the femur accompanied by malignant fibrous histiocytoma is presented. The patient complained of a dull intermittent pain, for three months, along the anterolateral aspect of the right knee and was referred to Southwest Hospital (Chongqing, China) in May 2013. All of the radiographic findings, including radiography, magnetic resonance image and emission computed tomography (CT) supported the diagn...

  16. Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hye Young; Seo, Jung Wook; Lee, Byung Hoon; Lee, Ji Young; Kim, Su Young; Cha, Soon Joo; Kim, Yong Hoon; Hwang, Yoon Joon; Kim, You Sung [Dept. of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang (Korea, Republic of)

    2013-03-15

    A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

  17. Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features

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    Mertens Fredrik

    2011-10-01

    Full Text Available Abstract Background The diagnostic entity malignant fibrous histiocytoma (MFH of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a series of 57 so-called MFH of bone within the framework of the EuroBoNeT consortium according to up-to-date criteria and ancillary immunohistochemistry, a fourth of all tumors were reclassified and subtyped. Methods In the present study, the cytogenetic data on 11 of these tumors (three myoepithelioma-like sarcomas, two leiomyosarcomas, one undifferentiated pleomorphic sarcoma with incomplete myogenic differentiation, two undifferentiated pleomorphic sarcomas, one osteosarcoma, one spindle cell sarcoma, and one unclassifiable biphasic sarcoma are presented. Results All tumors were high-grade lesions and showed very complex karyotypes. Neither the overall pattern (ploidy level, degree of complexity nor specific cytogenetic features distinguished any of the subtypes. The subgroup of myoepithelioma-like sarcomas was further investigated with regard to the status of the EWSR1 and FUS loci; however, no rearrangement was found. Nor was any particular aberration that could differentiate any of the subtypes from osteosarcomas detected. Conclusions chromosome banding analysis is unlikely to reveal potential genotype-phenotype correlations between morphologic subtypes among so-called MFH of bone.

  18. Malignant fibrous histiocytoma of the oral and maxillofacial region: a report of three cases

    International Nuclear Information System (INIS)

    Malignant fibrous histiocytoma (MFH) is a pleomorphic soft tissue sarcoma. Three cases of MFH were reported in our study. The first case involved in the right infratemporal fossa of a 32-year-old female was presented. MR imaging revealed a 5.0 x 3.3 cm soft tissue mass of inhomogeneous high signal intensity. The second caes was found in the right hard palate of a 66-year-old male. CT demonstrated bone destruction and MR imaging showed a 4 x 4 cm sized soft tissue mass of heterogeneous high signal intensity. The final case was found in the left masticator space of a 37-year-old male. The CT image showed a large mass with massive bone destruction of the left mandibular ramus, while the MRI displayed a soft tissue mass, 8 cm diameter. Our cases exhibited the general features of MFH. MRI is essential in the imaging of MFH, namely to depict tumor borders and demonstrate relationships with adjacent structures.

  19. Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability.

    Science.gov (United States)

    Chandrakasan, Shanmuganathan; Ye, Christine J; Chitlur, Meera; Mohamed, Anwar N; Rabah, Raja; Konski, Andre; Heng, Henry H Q; Sava?an, Süreyya

    2011-07-01

    Secondary malignancies (SMs) in Hodgkin lymphoma (HL) are thought to be related to exposure to alkalating agents, topoisomerase II inhibitors and ionizing radiation, and tend to occur a decade after initial therapy. We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL. The MFH and post-surgical reactive tissues exhibited multiple clonal abnormalities. In addition, PHA-stimulated peripheral blood lymphocytes showed increased frequency of non-clonal chromosomal aberrations. The potential role of genomic instability in early onset of SM in our patient is discussed. PMID:21488163

  20. Thermoradiotherapy in the treatment of soft-tissue malignant fibrous histiocytoma of the extremities

    International Nuclear Information System (INIS)

    From 1982 through 1989, five patients with soft-tissue malignant fibrous histiocytoma (MFH) of the extremities were treated with thermoradiotherapy in Kyoto University Hospital. All patients were male, and their ages ranged from 66 to 84 years. All of the tumors were locally recurrent ones following initial treatments. The initial treatments included wide excision followed by chemotherapy in one tumor, local excision with postoperative radiotherapy (60 Gy/2 Gy) in one tumor, and one to three times of local excision in the remaining three tumors. Hyperthermia was administered by an 8 MHz RF capacitive heating device or a 430 MHz microwave hyperthermia system for a total of 3 to 12 sessions (mean: 7 sessions). The total radiation dose ranged from 25 Gy to 70 Gy. regarding the tumor response, two tumors showed complete regression (CR), two showed no response (NR; less than 50% regression), and one tumor was resected 4 months after the treatment, in which no malignant tumor cells were detected by histological examination. Thus, good tumor response was obtained in three tumors. In addition, none of these tumors have shown recurrence in the follow up period of 4 to 36 months (mean: 15 months). CT scans performed after thermoradiotherapy demonstrated remarkable intratumor low density area in effectively heated tumors, and this CT change was useful to evaluate the initial effects of thermoradiotherapy. No serious complications associated with the combined treatment were notedted with the combined treatment were noted in this study. These results suggest that hyperthermia is a useful adjuvant to radiotherapy in the treatment of soft-tissue MFH of the extremities. (author)

  1. Epithelioid sarcoma resembling benign fibrous histiocytoma.

    Science.gov (United States)

    Lynch, Michael C; Graber, Emmy M; Johnson, T Shane; Clarke, Loren E

    2015-02-01

    Epithelioid sarcoma (ES) is a rare malignancy notorious for its tendency to histologically mimic granuloma annulare and other palisading granulomatous processes. We report a case of ES on the right hand of a 23-year-old man that histopathologically resembled a benign fibrous histiocytoma. Superficial portions of the tumor were well differentiated, exhibiting spindled and ovoid cells with scant cytoplasm that surrounded sclerotic collagen bundles. More obvious atypia including greater cellularity, nuclear pleomorphism, and mitotic activity were mostly confined to the deep-seated regions of the tumor. In addition to palisading granulomatous processes, ES can mimic benign fibrous histiocytoma, and the superficial portions of ES may appear deceptively benign. PMID:25750961

  2. Primary malignant fibrous histiocytoma of the abdominal cavity: CT findings and pathological correlation

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    Bivek Karki

    2012-01-01

    Full Text Available AIM: To study computed tomography (CT features of abdominal malignant fibrous histiocytoma (MFH in various rare locations. METHODS: We retroprospectively identified cases of MFH involving the abdominal cavity. Particular attention was paid to details regarding imaging features and histological types. RESULTS: The study population consisted of seven men and one woman, with a mean age of 52.5 years. Seven patients had some physical symptoms, while one was incidentally detected. The sites of origin were liver (n = 3, greater omentum (n = 1, superior mesentery (n = 1, ileum (n = 1, right psoas muscle (n = 1 and right kidney (n = 1. With the exception of the ileum lesion, all were of huge size. The contour of the lesions was more or less clear. Foci of necrosis were present in six lesions (n = 6. On plain CT scan, all lesions were hypo to iso dense. The lesion in the greater omentum was cystic. One lesion (n = 1 showed significant enhancement and the cystic lesion showed mild peripheral enhancement. An abundance of blood vessels surrounding the mass was seen in two lesions (n = 2 and both were of the inflammatory variety. Pathological examination revealed storiform-pleomorphic variety (n = 4, inflammatory variety (n = 3 and myxoid variety (n = 1. Two of the patients with inflammatory MFH had a clinical presentation of fever and one was afebrile, however, blood investigations in all three showed leukocytosis. CONCLUSION: Primary MFHs of the abdominal viscera and gastrointestinal tract are generally huge soft tissue masses containing areas of low attenuation and mild to moderate contrast enhancement.

  3. Primary dedifferentiated liposarcoma of the femur presenting with malignant fibrous histiocytoma: A case report and review of the literature.

    Science.gov (United States)

    Zhang, Shuai; Wang, Xu-Quan

    2014-08-01

    In the current report a case of a 26-year-old male with a primary dedifferentiated liposarcoma of the femur accompanied by malignant fibrous histiocytoma is presented. The patient complained of a dull intermittent pain, for three months, along the anterolateral aspect of the right knee and was referred to Southwest Hospital (Chongqing, China) in May 2013. All of the radiographic findings, including radiography, magnetic resonance image and emission computed tomography (CT) supported the diagnosis of a primary malignant bone tumor. CT-guided biopsy results demonstrated blood clots and a small quantity of heterogeneous cells. Thus, a limb-salvage procedure, involving a wide resection and total knee endoprosthesis replacement, was performed in May 2012. The final pathological diagnosis was of a primary dedifferentiated liposarcoma of the femur and the dedifferentiated tissue was identified as malignant fibrous histiocytoma. On review of the literature, it was identified that primary intraosseous liposarcoma are a rare and malignant tumor of the skeletal system, with only a small number of cases reported in the English literature since 1980. To the best of our knowledge, a case of dedifferentiated liposarcoma has not previously been reported. PMID:25013482

  4. Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts.

    Science.gov (United States)

    Oda, Yoshinao; Tamiya, Sadafumi; Oshiro, Yumi; Hachitanda, Yoichi; Kinukawa, Naoko; Iwamoto, Yukihide; Tsuneyoshi, Masazumi

    2002-09-01

    Recently, the category of malignant fibrous histiocytoma (MFH) has been under discussion and new entities resembling MFH have appeared. To clarify the recent situation regarding MFH, we reassessed previously diagnosed MFH cases in accordance with the most up-to-date diagnostic criteria, which included allied tumors. We carefully reassessed 428 cases that had been diagnosed in our institute during the past 28 years. Moreover, we searched for clinicopathological prognostic factors among the cases that were finally diagnosed as MFH. Among the 428 cases, 138 cases had their diagnoses changed. The revised cases included 78 leiomyosarcomas (57%; ordinary leiomyosarcoma, 45 cases; pleomorphic leiomyosarcoma, 23 cases; myxoid leiomyosarcoma, 10 cases), 12 liposarcomas (9%; pleomorphic liposarcoma, 11 cases; dedifferentiated liposarcoma, one case), seven dermatofibrosarcoma protuberans (5%), six unclassified sarcomas (4%), five primary or metastatic carcinomas (4%), four low-grade fibromyxoid sarcomas (3%), four inflammatory myofibroblastic tumors (3%), three rhabdomyosarcomas (2%), three malignant peripheral nerve sheath tumors (2%), three acral myxoinflammatory fibroblastic sarcomas (2%) and two atypical fibroxanthomas (1.5%). Among the 1974 soft tissue sarcomas registered in our institute, MFH (428 cases) had been the most common sarcoma, followed by liposarcoma, leiomyosarcoma and rhabdomyosarcoma. However, after reassessment, leiomyosarcoma proved to be the most common soft tissue sarcoma (322 cases), followed by 290 MFH, 273 liposarcomas and 202 rhabdomyosarcomas. Among these 290 cases finally diagnosed as MFH, survival data were available in 189 cases. Tumor location in the abdominal cavity, the retroperitoneum or the head and neck (P = 0.0024), tumor size of 5 cm or more (P < 0.0001), deep tumor location (P < 0.0001), high histological grade (grade 3) based on the French Federation of Cancer Centers' grading system (P = 0.0007), and high stage (stage III or IV) based on the American Joint Committee on Cancer (AJCC) staging system (P < 0.0001) were significantly worse prognostic factors by univariate analysis. In multivariate analysis, deep tumor location and high AJCC stage were independent adverse prognostic factors. We conclude that leiomyosarcoma is the most important differential diagnosis for MFH, especially pleomorphic leiomyosarcoma from storiform-pleomorphic type and myxoid leiomyosarcoma from myxoid type. Tumor depth and AJCC stage are the most important predictive prognostic factors in MFH. PMID:12406189

  5. Malignant fibrous histiocytoma of the deep peri-articular tissue of the stifle in a dog : case report

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    M.J. Booth

    2012-07-01

    Full Text Available A Belgian shepherd dog aged 4 years and 9 months was presented with acute onset of non-weight bearing lameness and stifle effusion of the left hind limb, caused by the deep form of a malignant fibrous histiocytoma originating in the deep musculature and fascia surrounding the stifle joint. The tumour progressed rapidly in the tissues along the femoral diaphysis with marked periosteal new bone formation. Cytology of a stifle joint aspirate revealed numerous large polygonal neoplastic cells with considerable anisocytosis and anisokaryosis. These cells were present in clusters, with cytoplasmic projections between the cells, but occasionally also occurred singly. Several cells contained multiple cytoplasmic vacuoles and occasional giant cells were also encountered. Adequate tumour-free margins were not possible with radical limb amputation and the dog was euthanased. Macroscopically the tumour appeared as an extensive pale tan, firm mass with scattered small haemorrhages and foci of yellow discolouration. Histologically the tumour consisted of dense neoplastic expanses or multiple nodules, composed of spindle-shaped fibroblastic cells, polygonal histiocytic cells or cell clusters and scattered giant cells with 2-3 nuclei. The polygonal neoplastic cells were frequently present around and invading lymphatics and blood vessels, causing neoplastic emboli. This is the 1st report of the clinical behaviour, radiography and cytology of the deep form of malignant fibrous histiocytoma in the dog.

  6. A new complication of retained surgical gauze: development of malignant fibrous histiocytoma – report of a case with a literature review

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    Kaplan Mehmet

    2012-07-01

    Full Text Available Abstract Background Primary visceral malignant fibrous histiocytoma (MFH is a rare disease, and few cases have been reported in the English literature. However, retained foreign bodies in the abdomen after surgical procedures are important causes of intra-abdominal infections. For legal and ethical reasons, there are few publications in the literature. In this article, we describe for the first time a case of malign abdominal fibrous histiocytoma associated with a surgical sponge forgotten in the abdominal cavity a long time ago. Case presentation A 64-year-old male presented to our surgical department with cachexia, abdominal pain, distention and pyrexia of unknown origin. He had a medical history of abdominal surgery for peptic ulcer perforation 32?years ago. Clinical examination revealed fever with a distended and painful abdominal wall. Radiological imaging of the abdomen showed multiple heterogeneous masses in one large cystic cavityalmost completely filling the abdomen. The patient underwent a laparotomy, and interestingly, opening the cyst revealed retained surgical gauze (RSG. The origin of the tumor was the visceral peritoneum, and it was excised totally. Conclusions Primary intra-abdominal MFH can present as a complication of long-lasting RSG. Therefore, clinicians must remember this while establishing the differential diagnosis for patients with a history of previous abdominal surgery and presenting with symptoms associated with both the tumor and systemic inflammatory response.

  7. Histiocitoma fibroso maligno de vejiga: Revisión bibliográfica / Malignant fibrous histiocytoma of the bladder: A literature review

    Scientific Electronic Library Online (English)

    I., Povo-Martín; D., Gallego-Vilar; M., Bosquet-Sanz; J., Miralles-Aguado; V., Gimeno-Argente; M., Rodrigo-Aliaga; J., Gallego-Gómez.

    2010-04-01

    Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivos: El histiocitoma fibroso maligno (HFM) es un tumor poco frecuente del tracto urinario. Pretendemos actualizar los criterios diagnósticos, las características anatomopatológicas e inmunohistoquímicas, la clasificación histológica, los factores pronóstico y las alternativas terapéuticas. Mat [...] erial y métodos: Revisión bibliográfica y estudio descriptivo de los casos de HFM de vejiga publicados en la literatura médica internacional. Resultados: Existen 29 casos publicados de HFM de vejiga y las variantes morfológicas más frecuentes son la estoriforme-fascicular (41%) y la inflamatoria (36%). Las variantes no mixoides comportan peor pronóstico. El 72% fue T3 en el momento del diagnóstico. La tasa de recurrencia local y a distancia del HFM de vejiga fue del 50 y del 25%, respectivamente, tras tratamiento exclusivamente quirúrgico. Conclusiones: El HFM de vejiga es un tumor con alta tasa de recurrencia local y a distancia, así como baja supervivencia, requiriendo un tratamiento precoz y agresivo. La cistectomía radical con linfadenectomía y radioterapia adyuvante, con eventual quimioterapia, se considera el tratamiento de elección. Abstract in english Objectives: Malignant fibrous histiocytoma (MFH) is an uncommon urinary tract tumor. This paper is intended to provide an update on its diagnostic criteria, pathological and immunohistochemical characteristics, histological classification, prognostic factors, and alternative treatments. Materials an [...] d methods: All published articles on MFH of the urinary bladder have been reviewed and a descriptive study has been done. Results: Twenty-nine cases of MFH of the bladder have been reported. The most common morphological variants are storiform-fascicular (41%) and inflammatory (36%) MFH. Non-myxoid variants have a poorer prognosis. Stage T3 MFH was found in 72% of cases at the time of diagnosis. MFH local recurrence and distant metastasis rates were 50% and 25% respectively after surgical treatment only. Conclusions: MFH of the bladder is a tumor with high local and distant recurrence rates and a low survival rate, and therefore requires early and aggressive treatment. Radical cystectomy with lymphadenectomy and adjuvant radiotherapy is considered to be the treatment of choice, eventually associated to chemotherapy.

  8. Primary malignant fibrous histiocytoma (myxofibrosarcoma/pleomorphic sarcoma not otherwise specified) of the breast: clinicopathologic study of 19 cases.

    Science.gov (United States)

    Hartel, Paul H; Bratthauer, Gary; Hartel, James V; Fanburg-Smith, Julie C

    2011-12-01

    We present 19 cases of primary breast malignant fibrous histiocytoma (MFH) or myxofibrosarcoma/pleomorphic sarcoma not otherwise specified, the largest series to date, and compare our results with those in the literature to better define MFH in this anatomical location. Twenty-seven cases (MFH, myxofibrosarcoma, or pleomorphic sarcoma not otherwise specified) were reviewed using World Health Organization and French Federation of Cancer Centers criteria. Inclusion required location within breast parenchyma without extensive chest wall involvement. Morphological features were recorded, and immunohistochemistry was applied. Clinical data were extracted from patients' medical records. Clinically, there was 1 male patient. Of 15 patients with follow-up, 5 (33% overall) died of disease within an average of 7 months after diagnosis. Distant metastases and older patient age were associated with poor survival. Storiform-pleomorphic subtype was most common (10/19) with myxofibrosarcoma (6/19) and giant cell subtype (1/19) also observed. Unique lymphocyte-rich (1/19) and pleomorphic hyalinizing angiectatic tumor-like (1/19) morphologies are presented. Immunohistochemistry demonstrated expression of CD68 (71%), focal smooth muscle actin (36%), with rare focal estrogen and progesterone receptor immunoreactivity. All cases were negative for CD34, S-100 protein, desmin 33, and keratins, including CK7, CK20, CK5/6, and CK18. Malignant fibrous histiocytoma occurs as a primary lesion in breast parenchyma. Attention to morphological detail and immunohistochemistry avoids misdiagnosis. Entrapped breast ductal epithelium should not be misinterpreted as the epithelial component of a biphasic tumor. A florid lymphoid response should not be confused with metaplastic carcinoma. Pleomorphic hyalinizing angiectatic tumor-like features may be observed in MFH. Our study confirms the presence of MFH in breast and presents unique morphological observations of primary breast MFH. PMID:21983422

  9. Diaphyseal medullary stenosis (sclerosis) with bone malignancy (malignant fibrous histiocytoma): hardcastle syndrome

    International Nuclear Information System (INIS)

    Hardcastle syndrome is a rare, autosomally dominant inherited skeletal dysplasia, characterized by diaphyseal sclerosis, medullary stenosis, pathological fractures, bony infarction, and malignant transformation. A 19-year-old proband is presented and discussed, adding a fourth family to the world literature. Radiographic screening of family members is suggested from puberty onward. Thallium scanning is proposed as a more tumor-sensitive screening agent in affected individuals. (orig.). With 2 figs

  10. Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization

    OpenAIRE

    Isayama Teruto; Ishiguro Masako; Nabeshima Kazuki; Iwasaki Hiroshi; Nishio Jun; Naito Masatoshi

    2010-01-01

    Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH) is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluorescence in situ hybridization (M-FI...

  11. Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report.

    Science.gov (United States)

    Bohn, Olga L; de León, Eric Acosta-Ponce; Lezama, Oscar; Rios-Luna, Nina P; Sánchez-Sosa, Sergio; Llombart-Bosch, Antonio

    2012-01-01

    Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses. The patient had no other primary malignant neoplasm, thus excluding a metastatic lesion. Gross examination revealed a thickened right pulmonary artery and a necrotic and hemorrhagic tumor, filling and occluding the vascular lumen. The mass extended distally, within the pulmonary vasculature of the right lung. Microscopically, an intravascular undifferentiated tumor was identified. The tumor cells showed expression for vascular markers VEGFR, VEGFR3, PDGFRa, FGF, Ulex europaeus, FVIII, FLI-1, CD31 and CD34; p53 was overexpressed and Ki67 proliferative rate was increased. Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome. PMID:23134683

  12. Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report

    Directory of Open Access Journals (Sweden)

    Bohn Olga L

    2012-11-01

    Full Text Available Abstract Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses. The patient had no other primary malignant neoplasm, thus excluding a metastatic lesion. Gross examination revealed a thickened right pulmonary artery and a necrotic and hemorrhagic tumor, filling and occluding the vascular lumen. The mass extended distally, within the pulmonary vasculature of the right lung. Microscopically, an intravascular undifferentiated tumor was identified. The tumor cells showed expression for vascular markers VEGFR, VEGFR3, PDGFRa, FGF, Ulex europaeus, FVIII, FLI-1, CD31 and CD34; p53 was overexpressed and Ki67 proliferative rate was increased. Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome. Virtual slide The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2315906377648045.

  13. Calculation of probability of causation for non-specified radiogenic cancer cases. Etiologic judgement of a malignant fibrous histiocytoma developed at the elbow of a plutonium contaminated worker

    International Nuclear Information System (INIS)

    A criterion for the compensation of patients with radiogenic cancer has been formulated for five specified cancers. A method of calculation of the probability of causation (PC) of non-specified cancers was applied to a case of malignant fibrous histiocytoma developed at the elbow of a plutonium contaminated worker. According to the histologic structure of the tumour, there were three possible target cells, and their doses were evaluated with the available data of urine plutonium. Then PC was calculated with excess relative risk coefficient indirectly deduced from related animal experiment. The result showed that the obtained PC varied greatly with the supposed target cells. If the target cells were periosteum cells, the PC might exceed 50 percent, but that might not be true, and the tumour might come from fibroblasts, and then PC might be less than 1 percent

  14. A case of radiation-induced sternal malignant fibrous histiocytoma treated with neoadjuvant chemotherapy and surgical resection

    OpenAIRE

    Erekul Selim; Budakoglu Burcin; Erdogan Bulent; Gulbahar Gultekin; Kocer Bulent; Dural Koray; Sakinci Unal

    2008-01-01

    Abstract Background Primary sternal malignant fibrous histiyocytoma (MFH) is highly rare. Effective treatment modality is surgical resection with wide margins. However, to date, the effects of radiotherapy or chemotherapy has not been clearly defined. Case presentation Herein, we aimed to present a 50-year old female patient with MFH occurred in the radiotherapy field who had had surgical procedure for breast cancer 19 years ago and had followed by radiotherapy. Neoadjuvant chemotherapy was a...

  15. Aneurysmal and haemangiopericytoma-like fibrous histiocytoma.

    OpenAIRE

    Zelger, B. W.; Zelger, B. G.; Steiner, H.; Ofner, D.

    1996-01-01

    AIM: To describe the clinicopathological features of 33 aneurysmal fibrous histiocytomas (AFH), including five cases with a haemangiopericytoma-like pattern. METHODS: Thirty three cases of AFH were studied by using routine histology and immunohistochemistry for factor XIIIa, the "cell activity marker" E9 (anti-metallothionein), NK1C3 (CD57), smooth muscle actin (SMA), factor VIII, ulex europaeus agglutinin, JC70A (CD31), and QBEND10 (CD34). The time dependent variation in histopathological fe...

  16. A case of radiation-induced sternal malignant fibrous histiocytoma treated with neoadjuvant chemotherapy and surgical resection

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    Erekul Selim

    2008-12-01

    Full Text Available Abstract Background Primary sternal malignant fibrous histiyocytoma (MFH is highly rare. Effective treatment modality is surgical resection with wide margins. However, to date, the effects of radiotherapy or chemotherapy has not been clearly defined. Case presentation Herein, we aimed to present a 50-year old female patient with MFH occurred in the radiotherapy field who had had surgical procedure for breast cancer 19 years ago and had followed by radiotherapy. Neoadjuvant chemotherapy was applied for MFH due to cardiac and mediastinal vascular invasion. Wide resection was carried out for the mass after having been decreased in size following neoadjuvant chemotherapy. Conclusion Neoadjuvant chemotherapy was an effective method. In planning the surgical resection, the size of the tumor before chemotherapy should be considered as the initial size and surgical margins should be determined accordingly.

  17. Multiple intracranial recurrent tumors with hyperprolactinemia combined with a parasellar malignant fibrous histiocytoma long after transfrontal surgery and irradiation to a pituitary adenoma.

    Science.gov (United States)

    Fujikawa, M; Okamura, K; Sato, K; Shiratsuchi, M; Yao, T; Mizokami, T; Fujishima, M

    2001-06-01

    We herein describe a 40-year-old woman with hyperprolactinemia, an empty sella and two extrasellar intracranial recurrent tumors which were revealed 23 years after the first transfrontal craniotomy and 18 years after the second transfrontal surgery and irradiation to a provable prolactin-producing pituitary macroadenoma. One recurrent tumor was in the right orbital apex causing right oculomotor nerve palsy, and the other tumor was in the right apex partispetrosae and foramen jugulare. Although her serum prolactin level decreased after the administration of bromocriptine mesilate, and the size of the two tumors remained unchanged, a malignant fibrous histiocytoma, which might have been induced by the irradiation 18 years before, grew rapidly in the right suprasellar-prepontine cistern to the right pedunculus cerebralis, leading to a poor prognosis. This case confirmed the importance of the life-lasting follow-up of pituitary adenomas treated with surgery and/or irradiation therapy. Not only ectopic recurrence of the primary tumor but also post-irradiation tumors may become apparent long after the removal of the primary tumor. PMID:11434670

  18. Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization

    Directory of Open Access Journals (Sweden)

    Isayama Teruto

    2010-11-01

    Full Text Available Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluorescence in situ hybridization (M-FISH, Urovysion™ FISH, and comparative genomic hybridization (CGH for the characterization of chromosomal aberrations. FU-MFH-2 cells were spindle or polygonal in shape with oval nuclei, and were successfully maintained in vitro for over 80 passages. The histological features of heterotransplanted tumors in severe combined immunodeficiency mice were essentially the same as those of the original tumor. Cytogenetic and M-FISH analyses displayed a hypotriploid karyotype with numerous structural aberrations. Urovysion™ FISH revealed a homozygous deletion of the p16INK4A locus on chromosome band 9p21. CGH analysis showed a high-level amplification of 9q31-q34, gains of 1p12-p34.3, 2p21, 2q11.2-q21, 3p, 4p, 6q22-qter, 8p11.2, 8q11.2-q21.1, 9q21-qter, 11q13, 12q24, 15q21-qter, 16p13, 17, 20, and X, and losses of 1q43-qter, 4q32-qter, 5q14-q23, 7q32-qter, 8p21-pter, 8q23, 9p21-pter, 10p11.2-p13, and 10q11.2-q22. Conclusion The FU-MFH-2 cell line will be a particularly useful model for studying molecular pathogenesis of human pleomorphic MFH.

  19. A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma".

    OpenAIRE

    Nair, V.; Weinreb, I.; Macneil, N.; Szollosi, Z.; Chetty, R.; Ghazarian, D.

    2008-01-01

    Dermatofibromas (cutaneous fibrous histiocytomas) are common cutaneous neoplasms of mesenchymal origin. They are often associated with epidermal hyperplasia and increased basal layer pigmentation. There have been reports of a spectrum of melanocytic lesions associated with dermatofibromas ranging from junctional nevi to malignant melanomas, some of which may be coincidentally associated. We report a case of a long-standing storiform fibrohistiocytic lesion devoid of cytological atypia, lackin...

  20. Case report 359: Gigantic benign fibrous histiocytoma (nonossifying fibroma)

    International Nuclear Information System (INIS)

    In summary, a fascinating case is presented of an enormous 'blow-out' lesion in the left half of the mandible in a 17-year-old boy. The histological diagnosis was benign fibrous histiocytoma or non-ossifying fibroma. An extensive differential diagnosis was presented by the authors and although benign fibrous histiocytoma was their final diagnosis, they could not exclude an example of the rarely encountered entity called the Jaffe-Campanacci syndrome. This syndrome consists of multiple non-ossifying fibromas of the mandible, cafe-au-lait spots, various endocrine disorders, mental retardation, occular anomalies and cardiovascular malformations. (orig./SHA)

  1. Angiomatoid fibrous histiocytoma in a 25-year-old male

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    David Dingli

    2010-06-01

    Full Text Available Angiomatoid fibrous histiocytoma (AFH is a rare disease that is often misdiagnosed initially. Patients can present with a clinical picture concerning for other diseases, and pathologic review is not always revealing. Molecular diagnostics are increasingly being utilized to detect gene fusions characteristic for AFH. Surgery remains the mainstay of management, and can effectively control local recurrences and metastases. Herein we describe a case report of a 25-year-old gentleman whose presentation was concerning for lymphoma. Subsequently we review of the relevant literature.

  2. Presentación de un caso de sarcoma maligno laríngeo, tratado mediante laringotomía transversa y revisión de la literatura / Transversal laryngotomy. Oncologic and functional results in laryngeal sarcoma.(Malignant fibrous histiocytoma). Case report and literature review.

    Scientific Electronic Library Online (English)

    Ángel F, Pérez; Rafael, Muñoz; Josefa, Morales; Ennio, Fereira; José Colina, Chourio.

    2008-03-01

    Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish Los sarcomas de la laringe son neoplasias que constituyen menos del 1% de los tumores malignos, y su tratamiento habitual es quirúrgico que incluye la laringectomía parcial o total y la cordectomía endoscópica con láser, con recurrencias de hasta 20%. Debido a experiencia positiva en nuestro país co [...] n la laringotomía transversa en casos de aritenoidectomía para tratar parálisis bilateral de las cuerdas vocales como consecuencia de tiroidectomía total, el propósito de este reporte fue el de informar el resultado obtenido con esta técnica de laringotomía transversa a un caso raro de sarcoma glótico en un médico de 47 años que tenía cuatro meses de disfonía moderada sin disnea, disfagia ni estridor y sin historia de radioterapia o quimioterapia previas. La lesión fue evaluada por endoscopia y tomografía laríngea que mostraron un tumor del lado derecho de la glotis de 3 a 4 cm de tamaño no ulcerado. El informe patológico fue de un fibrohistiocitoma maligno. Cinco años después el paciente está bien y sin evidencia de enfermedad. Abstract in english Sarcomas of the larynx are rare neoplasmas that consitute less than 1% of laryngeal malignancies, and their usual treatment is surgery including partial and total laryngectomy and endoscopic laser cordotomy with reported 20% recurrence. Due to previous positive experience from transversal laryngotom [...] y in patients who underwent aritenoidectomy to treat bilateral cord paralysis after total thyroidectomy, the purpose of this work was to report on the surgical treatment of this rare case with such technique. Thus, a 47 year-old physician who complained of hoarseness for four months without dyspnea, stridor, or dysphagia and with no history of irradiation or chemotherapy was operated after both endoscopic and tomographic studies showed a 3 to 4 cm glotic tumor in its right side, with no ulceration. The pathology proved to be malignant fibrous histiocytoma. Five years after surgery the patient is alive with no evidence of disease.

  3. A unique biphasic variant of cutaneous fibrous histiocytoma with a storiform pattern and intralesional pigmented melanocytes: "storiform melano-fibrous histiocytoma".

    Science.gov (United States)

    Nair, Vidhya; Weinreb, Ilan; MacNeil, Niki; Szollosi, Zoltan; Chetty, Runjan; Ghazarian, Danny

    2008-01-01

    Dermatofibromas (cutaneous fibrous histiocytomas) are common cutaneous neoplasms of mesenchymal origin. They are often associated with epidermal hyperplasia and increased basal layer pigmentation. There have been reports of a spectrum of melanocytic lesions associated with dermatofibromas ranging from junctional nevi to malignant melanomas, some of which may be coincidentally associated. We report a case of a long-standing storiform fibrohistiocytic lesion devoid of cytological atypia, lacking extension into subcutaneous fat, not demonstrating the t(17;22) DFSP translocation yet showing diffuse and strong CD34 immunoreactivity and containing pigmented spindle shaped melanocytic cells admixed with the fibrohistiocytic component. This case raises a nosological debate given the histological, immunophenotypic and cytogenetic findings. PMID:18474466

  4. Orbital solitary fibrous tumor: encompassing terminology for hemangiopericytoma, giant cell angiofibroma, and fibrous histiocytoma of the orbit: reappraisal of 41 cases.

    Science.gov (United States)

    Furusato, Emiko; Valenzuela, Ives A; Fanburg-Smith, Julie C; Auerbach, Aaron; Furusato, Bungo; Cameron, J Douglas; Rushing, Elisabeth J

    2011-01-01

    Hemangiopericytomas and solitary fibrous tumors are uncommon neoplasms found in many locations, including the orbit. Both mesenchymal neoplasms share several clinicopathologic features, thus prompting intense debate as to whether they are variants of the same entity or merit separate designations in the orbit. These 2 entities, with the addition of giant cell angiofibroma of orbit, are of benign- to uncertain-behavior, CD34-positive, collagen-rich, specialized fibroblastic tumors, which may have overlapping or histologically identical features. In addition, so-called fibrous histiocytoma of orbit, a previous designation, has overlapping morphologic features with these tumors. To date, a large series of these collagen-rich fibroblastic tumors of the orbit has not been fully explored. Forty-one fibroblastic orbital tumors, originally diagnosed as hemangiopericytomas (n = 16), fibrous histiocytomas (n = 9), mixed tumors (hemangiopericytomas/fibrous histiocytoma) (n = 14), and giant cell angiofibromas of orbit (n = 2) between 1970 and 2009, were retrieved from our consultation files, the Ophthalmic Registry, at the Armed Forces Institute of Pathology. Slides and clinical records were reviewed, analyzed, and compared. Immunochemistry was performed for CD34, CD99, Bcl-2, Ki-67, and p53. Upon histologic review, all cases were reclassified as solitary fibrous tumor (41/41). The patients included 23 (56%) males, 17 (41%) females, and 1 unknown, with a mean age at presentation of 40.7 years (range, 16-70 years). The sites of involvement were the right orbit in 18 (44%) cases and the left in 16 (39%) cases. Tumors ranged in size from 0.4 to 5.0 cm (mean, 2.2 cm). Seventeen (41%) patients presented with an orbital mass, 8 (20%) with proptosis, 2 (5%) with painful mass, and 2 (5%) with painless mass. Duration of symptoms ranged from 3 to 96 months, with a mean of 23 months (median, 9 months). Microscopically, all lesions showed considerable similarity, varying in degree of cellularity, stromal collagen, and the presence of giant cells. Overlapping features with soft tissue giant cell fibroblastoma were observed. Immunochemistry revealed positivity for CD34 in all cases (100%), p53 in 85%, CD99 in 67.5%, and Bcl-2 in 47.5%. Although Ki-67 labeling was seen in all cases, it ranged from less than 1% in 54.3% of cases to 5% to 10% in 20% of cases. Taken together, the findings of this study suggest that orbital hemangiopericytoma and some cases previously designated as fibrous histiocytoma, giant cell angiofibroma of orbit, and solitary fibrous tumor have overlapping morphologic and immunohistochemical features and should be designated as solitary fibrous tumor. Adipocytes and unusual multivacuolated adipocytic cells may be present in these tumors, as well stromal myxoid change; and even stromal intramembranous ossification can be observed. There are overlapping features of orbital solitary fibrous tumor with another CD34-positive specialized fibroblastic tumor of soft tissue, giant cell fibroblastoma. Morphologic criteria for uncertain behavior to low-grade malignant ocular solitary fibrous tumors can be made by cytologic atypia and increased mitotic activity, but overall outcome for malignant solitary fibrous tumors of the eye should be further explored. PMID:21056898

  5. Malignant Fibrous Histiocytosis of upper end of humerus- A Case Report

    Directory of Open Access Journals (Sweden)

    Sawarbandhe Sarang D1, and Arun Kumar Rao2

    2012-12-01

    Full Text Available Malignant fibrous histiocytoma, a type of sarcoma, is a malignant neoplasm ofuncertain originthat arises both in soft tissue and bone. Here we report a case ofMalignant Fibrous Histiocytosis (MFH of upper end of left humerus .Even though there are many cases of MFH reported in the bone, the incidencein upper end of humerus is rare. Histopathological examination many of the times isnot conclusive, as it is considered as a diagnosis of exclusion of sarcoma,which cannotbe more precisely categorized.

  6. A CASE REPORT OF BENIGN FIBROUS HISTIOCYTOMA OF PARANASAL SINUSES AND ROLE OF TRANSNASAL ENDOSCOPY IN ITS TREATMENT

    Directory of Open Access Journals (Sweden)

    M. H. Baradaranfar M. Moghimi

    2005-06-01

    Full Text Available Benign fibrous histiocytoma is a rare tumor of nose and paranasal sinuses that originates from histiocytes. ??The main symptoms of patients are nasal obstruction and nasal mass. ?Our patient was presented with chief complaints of nasal obstruction and rhinorrhea non responsive to antibiotic treatment. In computed tomography scan a giant mass in left maxillary sinus and ipsilateral nasal cavity was seen. After en bloc resection of tumor by transnasal endoscopic approach all of patient’s symptoms were alleviated. The pathologic report was benign fibrous histiocytoma. ?Because of excellent visualization, it seems that transnasal endoscopic approach is the method of choice for resection of these benign tumors.

  7. Case report 444: Subperiosteal malignant fibrous histocytoma (MFH) of thigh, with involvement of femur

    International Nuclear Information System (INIS)

    A case has been presented of subperiosteal malignant fibrous histiocytoma of the thigh eroding the femur in a 35-year-old woman. Plain films, radioisotope scans and CT studies were obtained. The lesion was mainly in the soft tissues but eroded the cortex of the femur. A local resection was performed with an excellent result (5-year-follow-up). The clinical, radiological and histological features of malignant fibrous histiocytoma were discussed in depth and the current modes of therapy were detailed. It was stressed that the lesion closely resembles fibrosarcoma and that eccentric lesions have a better prognosis than lesions arising directly in the marrow cavity of bone. Manifestations of this tumor at an atypical site initially presented difficulty in the clinical diagnosis. However, the histological pattern in association with the presence of giant cells confirmed the diagnosis, despite the absence of the typical storiform pattern in the tumor tissue. (orig.)

  8. Fibrohistiocitoma benigno ósseo na coluna lombar Benign fibrous histiocytoma of the lumbar spine

    Directory of Open Access Journals (Sweden)

    Osmar Avanzi

    2005-01-01

    Full Text Available CONTEXTO: O fibrohistiocitoma benigno intra-ósseo é uma neoplasia rara, caracterizada por proliferação fibroblástica e fibras colágenas. A dor na região lombar é uma queixa freqüente em muitos pacientes, mas, na maioria das vezes está relacionada com causa muscular ou degenerativa. RELATO DE CASO: Relata-se aqui o caso de um paciente com diagnóstico de fibrohistiocitoma benigno ósseo na coluna lombar que apresentava queixa de lombalgia há cinco meses antes do diagnóstico. Foi submetida à biópsia aberta transpedicular na quarta vértebra lombar ,e, posteriormente realizada curetagem da lesão via anterior retroperitonial e artrodese vertebral de L3-L5 com enxerto de fíbula. CONCLUSÃO: Apesar de raro, o fibrohistiocitoma benigno intra-ósseo deve ser uma das hipóteses quando observamos uma lesão primária na coluna vertebral.CONTEXT: Benign intraosseous fibrous histiocytoma is a rare neoplasia, characterized by fibroblastic and collagenous fiber proliferation. Pain in the lumbar region is a frequent complaint in many patients, but most of times it is associated to muscular or degenerative causes. CASE REPORT: Here we report a case of a patient diagnosed with benign bone fibrous histiocytoma in the lumbar spine who complained of lumbar pain dating five months prior to diagnosis. The patient was submitted to open transpedicular biopsy in the forth lumbar vertebra, and subsequently, lesion curettage was performed via anterior retroperitoneal and L3-L5 vertebral arthrodesis using a fibular graft. CONCLUSION: Although rare, benign intraosseous fibrohistiocytoma should be taken into consideration when a primary lesion is observed in the spine.

  9. Deep benign fibrous histiocytoma: computed tomography and histology findings; Histiocitoma fibroso benigno profundo: achados na tomografia computadorizada e histologia

    Energy Technology Data Exchange (ETDEWEB)

    Farage, Luciano; Castro, Mario Augusto Padula; Macedo, Tulio Augusto Alves [Uberlandia Univ., MG (Brazil). Hospital das Clinicas. Setor de Radiologia; Salomao, Eliana Chaves; Machado, Tania Alcantara; Souza, Lincoln Pereira de; Freitas, Luiz de Oliveira [Uberlandia Univ., MG (Brazil). Faculdade de Medicina. Dept. de Clinica Medica

    2005-04-01

    We present the computed tomography images of an 83-year-old male patient with a deep benign fibrous histiocytoma at the lateral aspect of the left leg. Computed tomography images showed a well-defined mass with marked peripheral enhancement by iodinated contrast medium. Only few reports of this rare soft tissue tumor can be found in the literature. (author)

  10. Fibrohistiocitoma benigno ósseo na coluna lombar / Benign fibrous histiocytoma of the lumbar spine

    Scientific Electronic Library Online (English)

    Osmar, Avanzi; Lin Yu, Chih; Robert, Meves; José Donato, Próspero; Amarildo, Brito.

    Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese CONTEXTO: O fibrohistiocitoma benigno intra-ósseo é uma neoplasia rara, caracterizada por proliferação fibroblástica e fibras colágenas. A dor na região lombar é uma queixa freqüente em muitos pacientes, mas, na maioria das vezes está relacionada com causa muscular ou degenerativa. RELATO DE CASO: R [...] elata-se aqui o caso de um paciente com diagnóstico de fibrohistiocitoma benigno ósseo na coluna lombar que apresentava queixa de lombalgia há cinco meses antes do diagnóstico. Foi submetida à biópsia aberta transpedicular na quarta vértebra lombar ,e, posteriormente realizada curetagem da lesão via anterior retroperitonial e artrodese vertebral de L3-L5 com enxerto de fíbula. CONCLUSÃO: Apesar de raro, o fibrohistiocitoma benigno intra-ósseo deve ser uma das hipóteses quando observamos uma lesão primária na coluna vertebral. Abstract in english CONTEXT: Benign intraosseous fibrous histiocytoma is a rare neoplasia, characterized by fibroblastic and collagenous fiber proliferation. Pain in the lumbar region is a frequent complaint in many patients, but most of times it is associated to muscular or degenerative causes. CASE REPORT: Here we re [...] port a case of a patient diagnosed with benign bone fibrous histiocytoma in the lumbar spine who complained of lumbar pain dating five months prior to diagnosis. The patient was submitted to open transpedicular biopsy in the forth lumbar vertebra, and subsequently, lesion curettage was performed via anterior retroperitoneal and L3-L5 vertebral arthrodesis using a fibular graft. CONCLUSION: Although rare, benign intraosseous fibrohistiocytoma should be taken into consideration when a primary lesion is observed in the spine.

  11. Benign fibrous histiocytoma (dermatofibroma) of the face: clinicopathologic and immunohistochemical study of 34 cases associated with an aggressive clinical course.

    Science.gov (United States)

    Mentzel, T; Kutzner, H; Rütten, A; Hügel, H

    2001-10-01

    Thirty-four cases of fibrous histiocytoma (dermatofibroma) arising on the face are reported. These neoplasms occurred frequently in females (24 female, 10 male) and showed a broad age range (12 to 85 years; mean: 43.6 years, median: 41 years). The neoplasms originated on the forehead (nine cases), the cheek (eight cases), the eyebrow (four cases), the temporal region (three cases), the nose (two cases), and the ear (one case); in seven cases the location face was given only. Five of 27 cases with follow-up information (median: 5 years) recurred locally; in one case four recurrences were excised within 8 years. The majority of cases extended into the subcutis and deep soft tissue including striated muscle (50% of cases). Histologically, only the minority of cases was composed entirely of histiocytoid and spindle-shaped tumor cells arranged in a storiform growth pattern. In many cases cellular fascicles and bundles of spindle-shaped tumor cells were noted in addition to classical morphological features of fibrous histiocytoma. A moderate mitotic rate (mean: 2.97 mitoses in 10 HPFs) was observed, and in few cases increased atypia was evident. Frank tumor necrosis and/or vascular invasion were not identified. Immunohistochemical studies revealed Factor XIIIa positivity in 13 out of 17, focal CD68 positivity in 6 out of 10, and alpha-smooth muscle actin positivity in 16 out of 19 cases tested. These lesions should be distinguished from dermatofibrosarcoma protuberans, including its fibrosarcomatous variant, leiomyosarcoma, and low-grade myofibroblastic sarcoma. Cases of fibrous histiocytoma of the face have to be excised with wider margins in comparison with examples of classical fibrous histiocytoma occurring on the extremities because of diffuse infiltration, involvement of deeper structures, and an increased rate of local recurrences. PMID:11801774

  12. Epithelioid benign fibrous histiocytoma of skin: clinico-pathological analysis of 20 cases of a poorly known variant.

    Science.gov (United States)

    Singh Gomez, C; Calonje, E; Fletcher, C D

    1994-02-01

    Twenty new cases of epithelioid fibrous histiocytoma, a distinctive but poorly recognized variant of cutaneous benign fibrous histiocytoma are described. Twelve patients were male and eight were female. The age of the patients ranged from 7 to 80 years (median 40 years). Six lesion arose on the lower limb, five on the upper limb, three around the shoulder, two on the abdomen and one each on the eyelid, inner canthus and anal margin. In one case the age and site were not stated. All lesions presented as a solitary, polypoid or slightly raised cutaneous nodule, ranging in size from 0.5 cm to 2 cm in greatest diameter. Follow-up in 14 cases (mean 22.7 months) revealed local recurrence after 42 months in one case. Histologically, the more polypoid tumours were characterized by an epidermal collarette. In all lesions prominent polygonal or rounded epithelioid cells with abundant eosinophilic cytoplasm, a vesicular nucleus and small eosinophilic nucleoli accounted for at least 50% of the tumour cell population. Individual cells were separated by somewhat hyalinized collagen, containing prominent blood vessels and a sparse mononuclear inflammatory cell infiltrate. The edge of the lesions, especially those that were non-polypoid, often showed more typical features of ordinary fibrous histiocytoma. The main differential diagnosis is with other cutaneous epithelioid neoplasms, especially Spitz naevus. PMID:8181804

  13. Stages of Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

    Science.gov (United States)

    ... is also called nuclear magnetic resonance imaging (NMRI). Bone scan : A procedure to check if there are rapidly dividing cells , such as cancer cells, in the bone. A very small amount of radioactive material is ...

  14. Treatment Option Overview (Osteosarcoma and Malignant Fibrous Histiocytoma of Bone)

    Science.gov (United States)

    ... killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected ... of radiation therapy. External radiation therapy uses a machine outside the body to send radiation toward the ...

  15. Fibrohistiocitoma conjuntival simulando pterígio atípico na região amazônica: relato de caso / Conjunctival fibrous histiocytoma simulating atipical pterygium in the Amazon region: case report

    Scientific Electronic Library Online (English)

    Roberto Murillo Limongi de Souza, Carvalho; Alexandre, Taleb; Giulianna Limongi de Souza, Carvalho; Marcos, Ávila.

    2010-12-01

    Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Relatamos um caso inédito na literatura brasileira de fibrohistiocitoma conjuntival descoberto durante projeto comunitário de larga escala realizado pela equipe do Centro de Referência em Oftalmologia do Hospital das Clínicas da Universidade Federal de Goiás na região amazônica. Paciente do sexo fem [...] inino, leucoderma, de 38 anos de idade, apresentava lesão vascularizada no olho direito no canto medial da conjuntiva bulbar e carúncula com extensão para o limbo e invadindo cerca de 2 mm da córnea medial com configuração semelhante a um pterígio. O exame histopatológico revelou lesão constituída por células fusiformes, com arranjo estoriforme e células histiocitárias gigantes. A imunohistoquímica revelou forte positividade para vimentina e as células neoplásicas foram negativas para AE1/ AE3, HMB 45, proteína S 100. O diagnóstico histopatológico foi de fibrohistiocitoma. A evolução poderá demonstrar o crescimento tumoral e a possibilidade de lesão maligna. Abstract in english An inedited case in the Brazilian literature of conjunctival fibrous histiocytoma discovered during a wide scale community project accomplished by the team of the Center of Reference in Ophthalmology of the Hospital das Clínicas da Universidade Federal de Goiás in the Amazon region is reported. A 38 [...] year-old caucasian woman presented with a vascularized lesion on the medial portion of the bulbar conjunctiva and caruncular region of the right eye with extension for the limbus and invading about 2 mm of the medial cornea resembling a pterygium. Pathologic findings revealed that the lesion was constituted by spindle-shaped cells, with storiform arrangement, and large histocytelike cells. The immunohistochemistry revealed strong positivity for vimentin and the neoplastic cells were negative for AE1/AE3, HMB 45, S 100 protein. The histopathologic diagnosis was fibrous histiocytoma. The evolution demonstrated the tumoral growth and the possibility of a malignant lesion.

  16. Fibrohistiocitoma conjuntival simulando pterígio atípico na região amazônica: relato de caso Conjunctival fibrous histiocytoma simulating atipical pterygium in the Amazon region: case report

    Directory of Open Access Journals (Sweden)

    Roberto Murillo Limongi de Souza Carvalho

    2010-12-01

    Full Text Available Relatamos um caso inédito na literatura brasileira de fibrohistiocitoma conjuntival descoberto durante projeto comunitário de larga escala realizado pela equipe do Centro de Referência em Oftalmologia do Hospital das Clínicas da Universidade Federal de Goiás na região amazônica. Paciente do sexo feminino, leucoderma, de 38 anos de idade, apresentava lesão vascularizada no olho direito no canto medial da conjuntiva bulbar e carúncula com extensão para o limbo e invadindo cerca de 2 mm da córnea medial com configuração semelhante a um pterígio. O exame histopatológico revelou lesão constituída por células fusiformes, com arranjo estoriforme e células histiocitárias gigantes. A imunohistoquímica revelou forte positividade para vimentina e as células neoplásicas foram negativas para AE1/ AE3, HMB 45, proteína S 100. O diagnóstico histopatológico foi de fibrohistiocitoma. A evolução poderá demonstrar o crescimento tumoral e a possibilidade de lesão maligna.An inedited case in the Brazilian literature of conjunctival fibrous histiocytoma discovered during a wide scale community project accomplished by the team of the Center of Reference in Ophthalmology of the Hospital das Clínicas da Universidade Federal de Goiás in the Amazon region is reported. A 38 year-old caucasian woman presented with a vascularized lesion on the medial portion of the bulbar conjunctiva and caruncular region of the right eye with extension for the limbus and invading about 2 mm of the medial cornea resembling a pterygium. Pathologic findings revealed that the lesion was constituted by spindle-shaped cells, with storiform arrangement, and large histocytelike cells. The immunohistochemistry revealed strong positivity for vimentin and the neoplastic cells were negative for AE1/AE3, HMB 45, S 100 protein. The histopathologic diagnosis was fibrous histiocytoma. The evolution demonstrated the tumoral growth and the possibility of a malignant lesion.

  17. Malignant transformation of fibrous dysplasia into chondroblastic osteosarcoma

    International Nuclear Information System (INIS)

    A case of malignant transformation of polyostotic fibrous dysplasia into maxillary chondroblastic osteosarcoma is presented. The clinical, radiographic, CT, MR imaging features and pathological findings of polyostotic fibrous dysplasia and its malignant transformation are described. Malignant transformation of fibrous dysplasia is rare and has not previously been described in the English literature in this location in McCune-Albright syndrome and in the absence of radiation treatment. (orig.)

  18. Histiocitoma fibroso benigno profundo: achados na tomografia computadorizada e histologia Deep benign fibrous histiocytoma: computed tomography and histology findings

    Directory of Open Access Journals (Sweden)

    Luciano Farage

    2005-04-01

    Full Text Available Apresentamos imagens de tomografia computadorizada de um paciente de 83 anos de idade com histiocitoma fibroso benigno profundo, na face lateral da perna esquerda, com evolução de longa data. À tomografia computadorizada observamos massa bem delimitada, ovalada, e que apresentava intenso realce periférico com uso do meio de contraste iodado. Este é um tumor de partes moles pouco freqüente e com raros relatos dos seus aspectos de imagem.We present the computed tomography images of an 83-year-old male patient with a deep benign fibrous histiocytoma at the lateral aspect of the left leg. Computed tomography images showed a well-defined mass with marked peripheral enhancement by iodinated contrast medium. Only few reports of this rare soft tissue tumor can be found in the literature.

  19. Histiocitoma fibroso benigno profundo: achados na tomografia computadorizada e histologia / Deep benign fibrous histiocytoma: computed tomography and histology findings

    Scientific Electronic Library Online (English)

    Luciano, Farage; Mário Augusto Padula, Castro; Túlio Augusto Alves, Macedo; Eliana Chaves, Salomão; Tânia Alcântara, Machado; Lincoln Pereira de, Souza; Luiz de Oliveira, Freitas.

    2005-04-01

    Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Apresentamos imagens de tomografia computadorizada de um paciente de 83 anos de idade com histiocitoma fibroso benigno profundo, na face lateral da perna esquerda, com evolução de longa data. À tomografia computadorizada observamos massa bem delimitada, ovalada, e que apresentava intenso realce peri [...] férico com uso do meio de contraste iodado. Este é um tumor de partes moles pouco freqüente e com raros relatos dos seus aspectos de imagem. Abstract in english We present the computed tomography images of an 83-year-old male patient with a deep benign fibrous histiocytoma at the lateral aspect of the left leg. Computed tomography images showed a well-defined mass with marked peripheral enhancement by iodinated contrast medium. Only few reports of this rare [...] soft tissue tumor can be found in the literature.

  20. Malignant transformation in monostotic fibrous dysplasia: clinical features, imaging features, outcomes in 10 patients, and review.

    Science.gov (United States)

    Qu, Nan; Yao, Weiwu; Cui, Xiaojiang; Zhang, Huizhen

    2015-01-01

    Malignant transformation in fibrous dysplasia (FD) is uncommon. The purpose of this study was to investigate clinical and imaging features, and outcomes of malignant transformation in monostotic FD.Data for 10 pathologically confirmed malignant transformations in monostotic FD from January 2005 to December 2013 were retrospectively reviewed. Patient data were recorded, and radiographs (n?=?10), computed tomography (CT) (n?=?5), magnetic resonance (MR) (n?=?4), and bone scintigrams (n?=?10) were evaluated for lesion location, margin, cortical destruction, marrow involvement, periosteal reaction, and soft tissue mass by 2 musculoskeletal radiologists with agreement by consensus. Clinical features, management, and prognosis were also analyzed for each of the 10 cases.There were 8 male and 2 female patients (mean age 46.5?±?15.9 years). The affected sites were the femur (n?=?4), humerus (n?=?2), tibia (n?=?3), and ilium (n?=?1). Five cases had received previous surgery and 5 cases had no history of surgery. No patients had been given prior irradiation treatment. For the 5 cases with surgery, radiographs and CT showed purely osteolytic lesions with poor margination in the curettage area (n?=?5), cortical destruction (n?=?5), obvious soft tissue mass (n?=?1), and mineralization (n?=?2). For the 5 cases without surgery, radiographs and CT identified poorly marginated, osteolytic lesions within or near the area with "ground-glass" opacity (n?=?4), cortical erosion (n?=?4), and mineralization (n?=?2). Magnetic resonance imaging (MRI) also identified lesions with heterogeneous signal intensity and pronounced enhancement. Bone scintigraphy revealed eccentric increased uptake of radionuclide in monostotic lesion (n?=?10). Pathology reports revealed osteosarcoma (n?=?7), fibrosarcoma (n?=?2), and malignant fibrous histiocytoma (MFH) (n?=?1). At the end of the study, 1 patient died from tumors, 1 patient was alive with lung metastasis, 1 patient experienced recurrence, and 7 patients were alive without recurrence.Patients with FD and a history of surgery should be followed up, for the osteolytic lesions in the operative areas strongly indicate the malignant transformation. The radiographic feature of FD-related malignancies is poorly marginated, mineralized, and osteolytic lesions with cortical destruction. Further investigations are needed to explore the pathogenesis of malignancies in FD and to establish optimal therapeutic strategies. PMID:25621678

  1. Malignant solitary fibrous tumor in anterior mediastinum with pleural metastasis simulating invasive thymoma

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jong Bum; Lee, Ju Won; Kim, Youn Jeong; Kim, Yeo Ju; Lee, Kyung Hee; Chu, Young Chae; Song, Ju Young; Yoon, Yong Han [Inha Univ. School of Medicine/Inha Univ. Hospital, Incheon (Korea, Republic of)

    2012-05-15

    Malignant solitary fibrous tumor, which arises in the anterior mediastinum, is rare. Its image findings simulate other mediastinal mass, such as malignant lymphoma, malignant thymic epithelial tumor or invasive thymoma. Here, we report a pleural malignant fibrous tumor of a 60 year old man who is presented with a well defined lobulating anterior mediastinal mass with pleural metastasis mimicking invasive thymoma with pleural seeding.

  2. Malignant solitary fibrous tumor in anterior mediastinum with pleural metastasis simulating invasive thymoma

    International Nuclear Information System (INIS)

    Malignant solitary fibrous tumor, which arises in the anterior mediastinum, is rare. Its image findings simulate other mediastinal mass, such as malignant lymphoma, malignant thymic epithelial tumor or invasive thymoma. Here, we report a pleural malignant fibrous tumor of a 60 year old man who is presented with a well defined lobulating anterior mediastinal mass with pleural metastasis mimicking invasive thymoma with pleural seeding

  3. Malignant transformation of fibrous dysplasia: A case report

    OpenAIRE

    Hatano, Hiroshi; Morita, Tetsuro; Ariizumi, Takashi; Kawashima, Hiroyuki; Ogose, Akira

    2014-01-01

    Secondary osteosarcoma from fibrous dysplasia (FD) is very rare. The etiology of FD is linked to activating missense mutations of the guanine nucleotide-binding protein ?-subunit (GNAS) gene, which encodes the stimulatory ? subunit of the G protein (Gs?) and is located at chromosome 20q13. These mutations are central to the pathogenesis of FD; however, it is not known whether Gs? mutations are retained following malignant transformation in FD. In addition, to the best of our knowledge, no...

  4. Malignant solitary fibrous tumor of breast: a rare case report

    OpenAIRE

    Yang, Lian-he; Dai, Shun-dong; Li, Qing-chang; Xu, Hong-tao; Jiang, Gui-yang; Zhang, Yong; Wang, Liang; Fan, Chui-feng; Wang, En-hua

    2014-01-01

    Solitary fibrous tumor (SFT) is rare mesenchymal neoplasm that has been originally and most often documented in the pleura. Recently, the ubiquitous nature of the SFT has been recognized with reports of involvement of numerous sites all over the body such as: upper respiratory tract, somatic tissue, mediastinum, head, and neck. Less than 10 cases SFT of breast have been reported. Herein, we presented a 52-year-old Asian female with SFT of breast, this tumor showed predominant malignant featur...

  5. Cutaneous histiocytoma - histological and imaging correlations. A case report.

    Science.gov (United States)

    Crisan, Diana; Gheuca Solovastru, Laura; Crisan, Maria; Badea, Radu

    2014-09-01

    Dermatofibroma (benign fibrous histiocytoma) represents one of the most common skin tumors. We present the case of a 52 year old female patient with a highly pigmented nodular lesion, localized on the right thigh. Dermoscopy completed the clinical diagnosis, but could not exclude a malignant tumour . Ultrasound examination (Dermascan C sonograms 20 MHz, 2D ultrasound, Doppler ultrasound, contrast enhanced ultrasound, and elastography) evidenced a highly vascularized lesion (peripheral type of vascularization), and a sonographic depth index of 8.3 mm. The histopathological examination confirmed the diagnosis of a benign fibrous histiocytoma with the histological Breslow index of 8 mm. The particularity of the case consists of the complex non-invasive and in real time imaging examination which describes the "in vivo" histology of the benign tumor lesion. PMID:25110771

  6. Myxoid Type of Malignant Fibrous Histiocytoma of the Maxillary Sinus: A Case Report

    Directory of Open Access Journals (Sweden)

    Amir Hossein Jafarian

    2011-04-01

    Amplified radical surgery is the first choice of treatment. The second surgery has special value to the recurrent patients. Radiotherapy alone or chemotherapy alone is not effective to MFH of head and neck region

  7. Malignant transformation of fibrous dysplasia: A case report.

    Science.gov (United States)

    Hatano, Hiroshi; Morita, Tetsuro; Ariizumi, Takashi; Kawashima, Hiroyuki; Ogose, Akira

    2014-07-01

    Secondary osteosarcoma from fibrous dysplasia (FD) is very rare. The etiology of FD is linked to activating missense mutations of the guanine nucleotide-binding protein ?-subunit (GNAS) gene, which encodes the stimulatory ? subunit of the G protein (Gs?) and is located at chromosome 20q13. These mutations are central to the pathogenesis of FD; however, it is not known whether Gs? mutations are retained following malignant transformation in FD. In addition, to the best of our knowledge, no studies have been performed on chromosomal analysis of secondary osteosarcoma from FD. The present study presents a case of secondary osteosarcoma arising from polyostotic FD in a 72-year-old male. Chromosomal analysis showed 44, X, -Y, add(4)(p11), add(5)(p15), der(11)add(11)(p15)t(1;11)(q21;q23), add(12)(q11), -13, der(22)t(12;22)(q11;p12). Reverse transcription-polymerase chain reaction (RT-PCR) analysis demonstrated the presence of a Gs? mutation in both the primary tumor cells and secondary osteosarcoma cells. There was no alteration in this mutation in the region of malignant transformation, which suggests that this mutation may be a useful clinical marker for distinguishing de novo osteosarcoma (primary osteosarcoma) from secondary osteosarcoma arising from FD. PMID:24959281

  8. Malignant fat-forming solitary fibrous tumor (lipomatous hemangiopericytoma) in the neck: Imaging and histopathological findings of a case

    OpenAIRE

    Carvalho, Alice Duarte; Abraha?o-machado, Lucas Faria; Viana, Cristiano Ribeiro; Castro Capuzzo, Renato; Mamere, Augusto Elias

    2013-01-01

    Fat-forming solitary fibrous tumor (SFT) is a rare variant of solitary fibrous tumor, a mesenchymal fibroblastic neoplasia with a particular branching hypervascular pattern. This tumor is usually classified as benign and only very few fat-forming SFTs with malignant histologic features have been reported. We report a histologically malignant fat-forming solitary fibrous tumor in a 61-year-old man, located in his neck. Ultrasonography examination was first performed showing a heterogeneous les...

  9. Anterior Skull Base Surgery for Secondary Malignancies in Retinoblastoma Survivors: Report of Two Cases

    OpenAIRE

    Ichimura, Keiichi; Nibu, Ken-ichi; Tanaka, Toshiyoshi; Takekoshi, Hideki; Sasaki, Tomio; Taniguchi, Makoto; Nakatsuka, Takashi

    1997-01-01

    With the improved survival rate of patients with retinoblastoma, the incidence of second malignancies has become substantial. We had two retinoblastoma survivors with secondary malignancies in the naso-ethmoidal complex, one a 21-year-old man with anaplastic carcinoma and the other a 16-year-old girl with malignant fibrous histiocytoma. They underwent repeated craniofacial surgery. Secondary malignancies arising at the nose and ethmoidal cells often invade the anterior skull base. The introdu...

  10. Primary malignant mesenchymoma of bone

    Directory of Open Access Journals (Sweden)

    Errol U. Hutagalung

    2001-11-01

    Full Text Available Pimary malignant mesenchymoma of bone (PMMB is an exceedingly rare neoplasm consisting of two or more unrelated malignant mesenchymal components other than fibrosarcoma or malignant fibrous histiocytoma. Review of the literature reports only 16 cases, most of which were composed of osteosarcoma and liposarcoma. We report a case af PMMB composed of liposarcoma,rhabdomyosarcoma and high grade chondrosarcoma arising within the left distal femur in a 52-year-old male, resulting in the patient's death 3 months after presentation. (Med J Indones 2001;10: 235-41Keywords: Bone tumor-malignancy, liposarcoma, dedifferentiated chondrosarcoma, rhabdomyosarcoma

  11. Peritoneal mesothelioma and malignant lymphoma in mice caused by fibrous zeolite.

    OpenAIRE

    Ozesmi, M.; Patiroglu, T. E.; Hillerdal, G.; Ozesmi, C.

    1985-01-01

    Dust from the village of Karain containing the fibrous zeolite erionite, talc, and physiological saline were tested by intraperitoneal injection in 486 Swiss albino mice. Malignant tumours were found in 84 (41 mesotheliomas, 31 lymphomas, 1 peripheral epidermoid carcinoma, and 11 lymphomas and mesotheliomas together) of the 321 animals which died spontaneously within nine to 32 months after injection of Karain dust (26.1%). Three mesotheliomas and no lymphomas were found among 24 animals inje...

  12. "Malignant" mitral stenosis

    OpenAIRE

    Auer Johann; Berent Robert; Gurtner Franz

    2012-01-01

    Abstract Symptomatic mitral stenosis caused by a left atrial mass as the first sign of metastasis of a malignant tumor is extremely rare and frequently associated with poor prognosis. We report a case of a 59-year-old man with a history of grade 3 malignant fibrous histiocytoma on his left tigh treated by limb-sparing surgery 17 months earlier, who was admitted with 10-days of worsening dyspnea. Imaging revealed a left atrial mass protruding through the mitral valve that resulted in severe mi...

  13. Pelvic limb-salvage surgery for malignant tumors

    OpenAIRE

    Pant, R.; Moreau, P.; Ilyas, I.; Paramasivan, O. N.; Younge, D.

    2000-01-01

    Thirteen patients with primary malignant tumors of the pelvis underwent internal hemipelvectomy. The diagnoses were: Ewing's sarcoma 7, osteosarcoma 4, chondrosarcoma 1, and malignant fibrous histiocytoma 1. No megaprostheses or massive allografts were used for reconstruction. Six patients underwent resection only with no reconstruction, 5 had strut grafts inserted to restore the pelvic ring, 1 had an autoclaved autograft of the acetabulum and 1 had an ilio-femoral arthrodesis. No patients we...

  14. Environmental fibrous zeolite (erionite) exposure and malignant tumors other than mesothelioma.

    Science.gov (United States)

    Bari?, B; Demir, A U; Shehu, V; Karakoca, Y; Kisacik, G; Bari?, Y I

    1996-01-01

    We studied the mortality in three villages in the Cappadocian region of Central Anatolia, Karain, Tuzköy, and Sarihidir, which were exposed to fibrous zeolite (erionite), a known carcinogen more potent than the amphibole asbestos. Between 1970 and 1994, there were 305 deaths in Karain, and 177 (58%) were cancer related, including 150 (49.2%) malignant pleural mesothelioma, seven (2.3%) malignant peritoneal mesothelioma, and six (1%) gastroesophageal carcinoma. Four deaths (1.3%) from lung cancer included two nonsmoking females. There were three cases (1%) of leukemia and six of other malignancies (1.9%). Between 1980 and 1994, there were 519 deaths in Tuzköy (T) and Sarihidir (S) (T = 432, S = 87). Of these, 257 were cancer related, and included 120 cases of malignant pleural mesothelioma and 64 cases of malignant peritoneal mesothelioma. Intraabdominal carcinoma was noted in 29 patients and 14 patients had lung cancer (four of whom were nonsmoking women). There were five cases of gastroesophageal cancer, five deaths due to leukemia, and 16 cases of various malignancies. These mortality figures support the hypothesis that erionite fibers cause cancer other than mesothelioma and lung cancer. Mineralogic analyses of the tissues should be performed to demonstrate this relationship. PMID:9216804

  15. Malignant fat-forming solitary fibrous tumor (lipomatous hemangiopericytoma) in the neck: Imaging and histopathological findings of a case.

    Science.gov (United States)

    de Carvalho, Alice Duarte; Abrahão-Machado, Lucas Faria; Viana, Cristiano Ribeiro; de Castro Capuzzo, Renato; Mamere, Augusto Elias

    2013-03-01

    Fat-forming solitary fibrous tumor (SFT) is a rare variant of solitary fibrous tumor, a mesenchymal fibroblastic neoplasia with a particular branching hypervascular pattern. This tumor is usually classified as benign and only very few fat-forming SFTs with malignant histologic features have been reported. We report a histologically malignant fat-forming solitary fibrous tumor in a 61-year-old man, located in his neck. Ultrasonography examination was first performed showing a heterogeneous lesion, predominantly hyperechoic, with sound beam attenuation, containing two hypoechoic solid nodules. Magnetic resonance imaging and computed tomography examinations demonstrated a heterogeneous and predominantly adipose mass, containing post contrast enhancing solid nodules and thin septations. Treatment consisted of total removal of the lesion. Histologically, the tumor showed hypercellularity, numerous mitoses and cytological atypia, fulfilling the criteria for malignancy. The patient had no metastasis. This rare tumor may be confused with other fat-containing lesions on imaging examinations, mainly liposarcoma. PMID:23705040

  16. [Giant malignant solitary fibrous tumor successfully resected via clamshell incision and lower door open thoracotomy].

    Science.gov (United States)

    Ishida, Itaru; Oura, Hiroyuki; Niikawa, Hiromichi; Handa, Masashi; Shibuya, Jotaro

    2012-02-01

    We report a case of a giant intrathoracic tumor successfully resected via clamshell incision and lower door open thoracotomy. A 62-year-old woman presented with cough and dyspnea on exertion. A chest computed tomography (CT) revealed a giant mass occupying nearly whole of the right hemithorax. Since the tumor infiltrated deeply into the lung parenchyma, we performed a right pneumonectomy. The 1st thoracotomy was performed at 4th intercostal clamshell incision. Then we divided lower sternum vertically and opened the right lower chest wall laterally. These procedures provided wide operative view from the apex to the diaphragm and excellent access to hilar constructions, and enabled enbloc resction of giant tumor with the right lung. The resected specimen was 25×19×12 cm in size, 2,830 g in weight, and histologically diagnosed as a malignant solitary fibrous tumor. We conclude that this approach is effective for excision of giant intrathoracic tumor. PMID:22314169

  17. CT findings in malignant pleural mesothelioma related to nonoccupational exposure to asbestos and fibrous zeolite (erionite)

    International Nuclear Information System (INIS)

    Endemic malignant pleural mesothelioma (MPM) in Turkey is related to two mineral fibers, tremolite asbestos and fibrous zeolite (erionite). Thirteen cases of MPM from the Cappadocian area, where the soil is rich in erionite, and 29 cases of MPM, from villages whose occupants have high asbestos exposure, were examined by CT. The CT findings of the two groups of MPM were compared with respect to the configuration of the pleural lesions, stage of disease, fissural involvement, pleural effusion, presence of calcified pleural plaques, and chronic fibrosing pleuritis. In erionite-related MPM the pleural lesions were flat and smooth in 69.1%; in asbestos-related MPM the lesions were nodular in 55.1%. Stage IV disease, calcified pleural plaques, and chronic fibrosing pleuritis were more common in the erionite-related MPM. The rest of the findings were similar in both groups. The early radiological diagnosis of erionite-related MPM may be even more difficult because of the similarity of the pleural lesions to chronic fibrosing pleuritis

  18. Renal malignant solitary fibrous tumor with single lymph node involvement: report of unusual metastasis and review of the literature

    Directory of Open Access Journals (Sweden)

    Mearini E

    2014-05-01

    Full Text Available Ettore Mearini,1 Giovanni Cochetti,1 Francesco Barillaro,1 Sonia Fatigoni,2 Fausto Roila2 1Department of Medical-Surgical Specialties and Public Health, Division of Urological Andrological Surgery and Minimally Invasive Techniques, University of Perugia, Terni, Italy; 2Medical Oncology, S Maria Hospital, Terni, Italy Abstract: Solitary fibrous tumors are rare mesenchymal spindle cell neoplasms that are usually found in the pleura. The kidneys are an uncommon site and only few cases of renal solitary fibrous tumor exhibit malignant behavior metastasizing to the liver, lung, and bone through the hematogenous pathway. Purpose: To describe the first case of lymph node metastasis from renal solitary fibrous tumor in order to increase the knowledge about the malignant behavior of these tumors. Patients and methods: A 19-year-old female patient had intermittent hematuria for several months without flank pain or other symptoms. A chest and abdomen CT scan was performed and showed a multi-lobed bulky solid mass of 170 × 98 × 120 mm in the left kidney. One day before the surgery, the left renal artery was catheterized and the kidney embolization was performed using a Haemostatic Absorbable Gelatin Sponge and polyvinyl alcohol. We then performed a radical nephrectomy with hilar, para-aortic, and inter-aortocaval lymphadenectomy. Results: Estimated intraoperative blood loss was 200 mL and the operative time was 100 minutes. No postoperative complications occurred. The hospital stay was 7 days long. The histological examination was malignant solitary fibrous tumor of the kidney. Cancerous tissue showed cellular atypia, with an increased mitotic index (up to 7 × 10 hpf. Immunohistochemical analysis showed positive results for CD34, BCL2, partial expression of HBME1, and occasionally of synaptophysin. Histological evaluation confirmed the presence of metastasis in one hilar node. The patient did not receive any other therapy. At 30-month follow-up, the patient was in good health and no local recurrence or metastases had occurred. Conclusion: This is the first case of lymph node metastasis from a renal solitary fibrous tumor showing unusual malignant behavior; this finding adds new information about the biology and progression of these tumors, which remain unclear. Keywords: solitary fibrous tumor, sarcoma, kidney, lymph node metastases, lymphadenectomy

  19. Epithelioid Cell Histiocytoma – An Unusual Variant of Dermatofibroma at an Uncommon Site

    Directory of Open Access Journals (Sweden)

    Shulbha VS

    2011-04-01

    Full Text Available Epithelioid cell histiocytoma (ECH is a rare variant of cutaneous fibrous histiocytoma involving primarily trunk and the extremities. It can delude the pathologist in considering other benign non neoplastic and neoplastic lesions. Awareness of this new entity can avert unnecessary treatment. We report a case of epithelioid cell histiocytoma in a 40 yr old male who presented with a painless nodular swelling over the dorsum of nose. The case is presented here for its rarity and an uncommon site of involvement.

  20. CT in malignant primary soft tissue tumours

    International Nuclear Information System (INIS)

    The results of CT examinations in 36 patients suffering from histologically confirmed malignant primary tumours of the soft tissues are presented (6 rhabdomyosarcomas, 4 leiomyosarcomas, 6 liposarcomas, 4 malignant schwannomas, 5 malignant fibrous histiocytomas, 4 malignant haemangiopericytomas, 3 angiosarcomas, 1 fibrosarcoma, 1 renal sarcoma, 2 malignant mesenchymal tumours without histologically clear classification). The CT image alone will not yield information on the type of tumour or on the tumour status. However, CT continues to rank in the diagnosis of tumours of the soft tissues and is even superior to MR especially in the identification of gas accumulations due to infection in a tumour of the soft tissues that is otherwise unclear. Comparing the literature conclude that MR is now the imaging method of choice in the diagnosis of soft tissue tumours. (orig.)

  1. Generalized eruptive histiocytoma

    Science.gov (United States)

    Aggarwal, Kamal; Gupta, Sanjeev; Jain, Vijay Kumar; Sen, Rajeev; Gupta, Sunita

    2010-01-01

    We are reporting a 62 year old male, who over a period of 1 year, developed a symmetric eruption of hundreds of brownish papules, with spontaneous regression of some lesions. The clinical and histopathological findings were compatible with the diagnosis of generalized eruptive histiocytoma. PMID:23130189

  2. Tumor fibroso solitario inguinal maligno: Aportación de un caso / Solitary malignant fibrous inguinal tumor: Case report

    Scientific Electronic Library Online (English)

    P., Garrido Abad; A., Coloma Del Peso; L. M., Herranz Fernández; M., Jiménez Gálvez; G., Bocardo Fajardo; R., Arellano Gañán; I., Pereira Sanz; T., Reina Durán.

    1200-12-01

    Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: El Tumor Fibroso Solitario (TFS) es una neoplasia poco frecuente que fue descrita por primera vez en la pleura, pero puede aparecer en diferentes localizaciones. Su presencia en la zona inguinal es extremadamente rara. Método/Resultados: Presentamos el caso de un varón de 74 años con masa [...] inguinoescrotal derecha de 50 años de evolución. Tras extirpación quirúrgica de la misma es diagnosticado de tumor fibroso solitario. Conclusiones: La inmensa mayoría de los tumores fibrosos solitarios se comportan de manera benigna. Un pequeño porcentaje se comporta de modo más agresivo, con recurrencia local y metástasis. Su tratamiento es eminentemente quirúrgico, pero después debemos realizar seguimiento a largo plazo en todos los casos. Abstract in english Objective: Solitary fibrous tumours (SFTs) are rare neoplasias that were first reported in pleura, but can occur in different sites. Inguinal location is extremely rare. Methods/Results: We report one case of a 74 year old man with a right inguinoscrotal mass with 50 years of evolution. After surgic [...] al extirpation, solitary fibrous tumour was diagno-sed. Conclusions: The vast majority of solitary fibrous tu-mours (SFTs) have a benign course. Only a few cases have aggressive behaviour, with local recurrence and metastasis. Treatment is surgical, but we must do a long-term follow up in all cases.

  3. A Case Report of a Malignant Fibrous Histiocytoma in a T-cell Receptor ? Chain and p53 Double-knockout Mouse

    OpenAIRE

    Ando, Minoru; Kado, Shoichi; Suzuki, Tomo; Yamamoto, Ryota; Nagata, Yuriko; Hata, Chie; Uchida, Kazumi; Kaneko, Kimiyuki

    2011-01-01

    A subcutaneous tumor was found in the right abdomen of a 16-week-old male TCR? and p53 double-knockout mouse. The tumor had indistinct borders with the surrounding tissue. The cut surface after formalin fixation was pale yellowish white, partially dark red and partly white. Histologically, the tumor was composed of three distinct regions. The first region showed pleomorphic cells arranged in sheets. The second region showed spindle cells ...

  4. Thermochemoradiotherapy for head and neck advanced malignant tumors

    International Nuclear Information System (INIS)

    Ten patients with advanced malignant tumor of head and neck were treated by combined treatment with chemoradiotherapy and hyperthermia. Histopathologically, squamous cell carcinoma was diagnosed in 7 patients, adenocarcinoma in 1, osteosarcoma in 1, and malignant fibrous histiocytoma in 1. The heating device was RF capacitive heating of external heating and magnetic induction hyperthermia of interstitial heating. Chemotherapy of high-dose MTX was used for osteosarcoma and malignant fibrous histiocytoma, and low-dose cisplatin was used for squamous cell carcinoma. Four patients with advanced malignant tumor of the primary lesion underwent thermochemoradiotherapy. Six patients with metastatic lymph nodes of N3 underwent preoperative thermochemoradiotherapy. As a result for primary lesion, CRh was observed in 1 patient, PRh in 2, and NCh in 1. And as results of clinical response and pathological response for metastatic lymph nodes of N3, PRh was observed in all 6 patients, and Gr. III in 1, Gr. II b in 3, Gr. II a in 2. The four-year cumulative survival rate of patients with metastatic lymph nodes on N3 was 50.0%. Combined preoperative chemoradiotherapy and hyperthermia was an effective therapeutic method for treating patients with metastatic lymph nodes of N3. (author)

  5. Aneurysmal dermatofibroma mimicking both clinical and dermoscopic malignant melanoma and Kaposi's sarcoma.

    Science.gov (United States)

    Morariu, Silviu Horia; Suciu, Mircea; Vartolomei, Mihai Dorin; Badea, Mihail Alexandru; Cotoi, Ovidiu Simion

    2014-01-01

    Aneurysmal dermatofibroma (AD) or aneurysmal fibrous histiocytoma (AFH) is a relatively rare form of histiocytoma representing less than 2% of total cases. It shares many clinical and dermoscopic similarities with skin tumors, especially malignant melanoma and Kaposi's sarcoma, which can make differentiation problematic. We report the case of a 53-year-old man, who presents with a black nodular tumor with increased consistency, edges infiltrated from the surface to depth, spontaneous and sensitive to touch that shows rapid growth in the last three months. Dermoscopically, the central region consists of intricate areas colored in red, violet, blue-white and black. On the periphery stand two rings, centrally white and peripherally pigmented, with an abundance of polymorphic capillaries. To clarify the diagnosis, the lesion was widely excised and histopathological examination was performed, which revealed immunophenotypical tumor cells negative for HMB-45 and S100, and numerous CD68 macrophages between tumor cells. This aneurysmal fibrous histiocytoma shows both clinical and dermoscopically discrete differential criteria, which are not specific and that make it difficult to distinguish from malignant melanoma and Kaposi's sarcoma, and required performing histopathology and immunohistochemistry. PMID:25607410

  6. Malignant solitary fibrous tumor with high-grade nuclear atypia: an alternate entity for the undetermined tumor group.

    Science.gov (United States)

    Yamada, Yuichi; Kohashi, Kenichi; Bekki, Hirofumi; Ishii, Takeaki; Iura, Kunio; Maekawa, Akira; Yamamoto, Hidetaka; Iwamoto, Yukihide; Oda, Yoshinao

    2015-02-01

    Recently, a novel fusion transcript, NAB2-STAT6, and its variants have also been reported to be specific diagnostic markers for solitary fibrous tumors (SFTs). In this study, we validated the existence of the NAB2-STAT6 fusion gene in SFTs and examined its relation with the pathological features. Frozen samples from 9 tumors were assessed for fusion gene. The detected fusion genes exhibited large intron sequences and the insertion of unknown and previously unreported sequences. The fusion genes were not detected in the 2 malignant cases with high-grade nuclear atypia, nuclear pleomorphism and necrosis, that was confirmed by multiplex PCR method. In addition, 1 of the 2 NAB2-STAT6 fusion gene-negative tumors showed amplification of the MDM2 and CDK4 genes. It was suggested that a certain proportion of tumors previously diagnosed as malignant SFTs with high-grade nuclear atypia lacking NAB2-STAT6 should be categorized into a special subtype of SFT, which is genetically different from conventional SFTs, and which cannot be apparently distinguished from dedifferentiated liposarcoma or undifferentiated pleomorphic sarcoma. PMID:25554652

  7. Doege-Potter syndrome presenting with hypoinsulinemic hypoglycemia in a patient with a malignant extrapleural solitary fibrous tumor: a case report

    Directory of Open Access Journals (Sweden)

    Schutt Robert C

    2013-01-01

    Full Text Available Abstract Introduction Doege-Potter syndrome is a paraneoplastic syndrome characterized by non-islet cell tumor hypoglycemia secondary to a solitary fibrous tumor. This tumor causes hypoglycemia by the secretion of a prohormone form of insulin-like growth factor II. We describe the diagnosis and management of Doege-Potter syndrome and the use of transarterial chemoembolization in a patient with a malignant extrapleural solitary fibrous tumor. Case presentation Our patient was a 64-year-old Caucasian woman who initially presented with urinary incontinence and was found to have a 14.5×9.0×9.0cm retroperitoneal solitary fibrous tumor compressing her bladder. Her tumor was surgically resected but recurred with multiple hepatic metastatic lesions. The hepatic metastases progressed despite systemic chemotherapy and treatment with doxorubicin transarterial chemoembolization. Her course was complicated by the development of recurrent fasting hypoglycemia, most likely secondary to Doege-Potter syndrome. Her hypoglycemia was managed with corticosteroid therapy and frequent scheduled nutrient intake overnight. Conclusions The rarity of hepatic solitary fibrous tumors and consequent lack of controlled trials make this report significant in that it describes the diagnostic approach to Doege-Potter syndrome, describes our experience with the use of doxorubicin transarterial chemoembolization, and presents management options for tumor-associated hypoglycemia in the case of extensive disease not amenable to surgical resection.

  8. A giant mesentery malignant solitary fibrous tumor recurring as dedifferentiated liposarcoma- a report of a very rare case and literature review.

    Science.gov (United States)

    Liu, Yang; Ishibashi, Haruaki; Sako, Shozou; Takeshita, Kazuyoshi; Li, Yan; Elnemr, Ayman; Yonemura, Yutaka

    2013-11-01

    We report a case of a 59-year-old woman with a very rare giant mesentery malignant solitary fibrous tumor that recurred as dedifferentiated liposarcoma. The woman was admitted to the hospital because of low abdominal pain. Radiological and biopsy findings revealed a multi-lobulated giant malignant solitary fibrous tumor that had invaded the inferior vena cava, abdominal aorta, and superior mesentery vessels. The tumor was completely removed during the first cytoreductive surgery. Histopathologically, tumor had a heterogeneous cell population, composed of spindle cells with fibrous collagen proliferation. The spindle cells were not arranged in a specific pattern. Immunohistochemistry revealed that the tumor cells were positive for CD34, CD99, Bcl-2, and smooth muscle actin( SMA) and negative for CD117, epithelial membrane antigen (EMA), CAM5.7, S100, desmin, and caldesmon. The tumor recurred 9 months after surgery, and another cytoreductive surgery was then performed. The postoperative histopathological appearance of the invaded area indicated a well-differentiated liposarcoma. Formation of tumorous bone was also noted in the same area, in addition to atypical mesenchymal cells and multi-vacuolated lipoblasts in the area of the well-differentiated liposarcoma. Proliferated spindle cells arranged in a storiform pattern were found in the area adjacent to the tumor. Immunohistochemical analysis revealed that the tumors cells were positive for SMA, HHF-35, and caldesmon and negative for CD117, CD34, and S100. A diagnosis of dedifferentiated liposarcoma was made. PMID:24394146

  9. Detection of c-fos expression in benign and malignant musculoskeletal lesions.

    Science.gov (United States)

    Weisstein, J S; Majeska, R J; Klein, M J; Einhorn, T A

    2001-05-01

    The proto-oncogene c-fos has been implicated in the development of both benign and malignant lesions of bone. Although c-fos expression in such lesions has been well studied in transgenic mouse models, less is known about its role in human musculoskeletal pathology. To clarify this relationship, we used in situ hybridization to localize c-fos m-RNA transcripts in 26 fibrous lesions (eight cases of extra-abdominal fibromatosis and six cases each of fibrous dysplasia, fibrosarcoma, and malignant fibrous histiocytoma of bone) as well as six chondrosarcomas and eight conventional high grade osteosarcomas. We found detectable levels of c-fos expression in tissues from each type of lesion tested. Moreover, all fibrous lesions consistently demonstrated high levels of expression in a majority of cells in each lesion. Chondrosarcomas and osteosarcomas exhibited more heterogeneity in c-fos expression than fibrous tissues. Three of six chondrosarcomas showed moderate expression of c-fos while only one of six was considered high. Similarly, only three of eight osteosarcomas had high expression of c-fos. These findings indicate that the expression of c-fos may be important in the development of a broad range of fibrous lesions as well as in bone and cartilaginous tumors. Additionally, this is the first report, to our knowledge, of detectable c-fos m-RNA in human chondrosarcoma. PMID:11398843

  10. Fibrous dysplasia.

    Science.gov (United States)

    Parekh, Selene G; Donthineni-Rao, Rakesh; Ricchetti, Eric; Lackman, Richard D

    2004-01-01

    Fibrous dysplasia is a developmental disorder of bone that can present in a monostotic or polyostotic form. Primarily affecting adolescents and young adults, it accounts for 7% of benign bone tumors. Many of the asymptomatic lesions are found incidentally; the remainder present with symptoms of swelling, deformity, or pain. Fibrous dysplasia has been associated with multiple endocrine and nonendocrine disorders and with McCune-Albright and Mazabraud's syndromes. The etiology remains unclear, but molecular biology suggests a mutation in the G(s)alpha subunit and activation of c-fos and other proto-oncogenes. Fibrous dysplasia has a characteristic radiographic appearance. Most cases do not require intervention, but those that do usually are managed surgically with curettage, bone grafting, and, in some cases, internal fixation. When some intervention is necessary but surgery is not practical, treatment is with bisphosphonates. The prognosis generally is good, although poor outcomes are more frequent in younger patients and in those with polyostotic forms of the disease. The risk of malignant transformation is low. PMID:15469225

  11. Multiple eruptive histiocytoma cutis in an atopic.

    Science.gov (United States)

    Ashworth, J; Archard, L; Woodrow, D; Cream, J J

    1990-11-01

    A case of generalized histiocytoma cutis occurring in an atopic and mimicking widespread molluscum contagiosum is described. Immunochemical staining showed that the lesions were positive for factor XIIIa. PMID:2177688

  12. Limb salvage in malignant tumors of appendicular skeleton

    International Nuclear Information System (INIS)

    A study was conducted at Jinnah Postgraduate Medical Centre, Karachi, to evaluate the results of various limb salvage techniques. Average age of the group of 12 subjects was 26.6 years and male to female ratio was 2.1. The histopathological diagnosis yielded recurrent GCT in 4 cases, chondrosarcoma in 3 cases, osteosarcoma. Ewing's sarcoma, parosteal osteosarcoma, adamantinoma and malignant fibrous histiocytoma in one case each. The surgical procedures included a wide variety of reconstructive methods. Adjuvant chemotherapy and radiotherapy were used where indicated. In terms of functional results, upper limb procedures scored 20.5 points (68%) and the lower limb procedures scored an average of 19 points (63%). Local recurrence rate was 25%. Minimum follow up period was four years. Complications included recurrence in three patients, pulmonary metastasis, soft tissue implantation, deep infection, non-union and graft absorption in one case each. (author)

  13. CT findings of uncommon malignant tumors of the liver

    International Nuclear Information System (INIS)

    Objective: To improve the diagnostic level of uncommon hepatic malignancy in 5 cases with different histopathological nature by analyzing their CT features. Methods: CT scan was performed in 5 cases with pathologically proved uncommon malignancy of the liver including hepatic sarcoma (n=3) and primary carcinoid tumor (n=2). Results: These uncommon malignancies of the liver had a variety of presentations. Undifferentiated embryonal sarcoma presented as a single huge cyst mixing with solid mass. Hepatic angiosarcoma demonstrated as multiple well-defined hypoattenuation lesions without cirrhosis. Necrosis, cystic degeneration, and hemorrhage may be accompanied. Malignant fibrous histiocytoma displayed as a single large hypoattenuation lesion within hyperdense septations, and most of the tumor was in the right lobe. Immunohistochemistry had the diagnostic value. The CT features of carcinoid tumor were single or multiple, unilocular or multilocular mixed-dense masses. The solid portion of the masses enhanced obviously and carcinoid syndrome may highly suggest the diagnosis. Conclusion: The forementioned 5 cases of hepatic malignancy are seldom seen clinically. Each of them with different pathologic nature has different CT findings, and sometimes with some similar signs. Typical CT findings, coupled with clinical information may lead to a correct diagnosis

  14. Spontaneous malignant transformation of conventional giant cell tumor

    Energy Technology Data Exchange (ETDEWEB)

    Grote, H.J.; Pomjanski, N.; Boecking, A. [Institute of Cytopathology, Heinrich Heine University, Moorenstrasse 5, 40225, Duesseldorf (Germany); Braun, M. [Orthopedic Hospital Volmarstein, University of Witten/Herdecke, Hartmannstrasse 24, 58300, Wetter (Ruhr) (Germany); Kalinski, T.; Roessner, A. [Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg (Germany); Back, W.; Bleyl, U. [Department of Pathology, Ruprecht Karls University Heidelberg, University Hospital Mannheim, Theodor-Kutzer-Ufer, 68167, Mannheim (Germany)

    2004-03-01

    Spontaneous malignant transformation of conventional giant cell tumor (GCT) of bone is exceedingly rare. We report on a case of GCT of the iliac crest in a 35-year-old woman with malignant change into a high-grade osteosarcoma 10 years after the first appearance of GCT on a radiograph. Since the patient refused therapy for personal reasons the tumor remained untreated until sarcomatous transformation occurred. Image cytometry showed DNA aneuploidy and a suspiciously high 2c deviation index (2cDI) in the primary bone lesion. A thorough review of the world literature revealed only seven fully documented cases of secondary malignant GCT which matched the definition of a ''sarcomatous growth that occurs at the site of a previously documented benign giant cell tumor'' and not treated by radiotherapy. These cases as well as the current one suggest that a spontaneous secondary malignant GCT presents as a frankly sarcomatous tumor in the form of an osteosarcoma or malignant fibrous histiocytoma. It usually appears at sites of typical GCTs - often without any recurrent intermediate state - and is diagnosed 3 or more years after the primary bone lesion. The prognosis is poor. (orig.)

  15. STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics.

    Science.gov (United States)

    Cheah, Alison L; Billings, Steven D; Goldblum, John R; Carver, Paula; Tanas, Munir Z; Rubin, Brian P

    2014-08-01

    Recurrent NAB2-STAT6 gene fusions have recently been identified in solitary fibrous tumour by next generation sequencing. Our aim was to examine the sensitivity and specificity of STAT6 immunohistochemistry for solitary fibrous tumour versus other morphologically similar soft tissue tumours. STAT6 expression was evaluated in 54 solitary fibrous tumours of various sites and 99 soft tissue tumours in the histological differential diagnosis. We used a rabbit monoclonal STAT6 antibody (1:100), which has not been reported by others, on formalin fixed, paraffin embedded whole sections and tissue microarray slides. Only nuclear staining of STAT6 was considered positive. Distribution of staining was scored as: 0 (no staining), 1+ (1-25%), 2+ (26-50%), 3+ (>50%). Intensity was scored as weak, moderate or strong. Nuclear STAT6 staining was present in all SFT cases tested (54/54, sensitivity 100%), regardless of histology, anatomical site or CD34 status. The majority of cases showed 3+ and strong staining. All tested cases of cellular angiofibroma (0/9), myofibroblastoma (0/10), spindle cell lipoma (0/10), benign fibrous histiocytoma (0/13), dermatofibrosarcoma protruberans (0/9), low-grade fibromyxoid sarcoma (0/7), schwannoma (0/8), desmoid-type fibromatosis (0/8), monophasic synovial sarcoma (0/11), malignant peripheral nerve sheath tumour (0/7), and mesenchymal chondrosarcoma (0/7) were negative for STAT6 (specificity 100%). Our study further supports the utility of STAT6 immunohistochemistry as an adjunct in the diagnosis of solitary fibrous tumour. PMID:24977739

  16. Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential.

    Science.gov (United States)

    Akaike, Keisuke; Kurisaki-Arakawa, Aiko; Hara, Kieko; Suehara, Yoshiyuki; Takagi, Tatsuya; Mitani, Keiko; Kaneko, Kazuo; Yao, Takashi; Saito, Tsuyoshi

    2015-03-01

    The impact of NGFI-A binding protein 2 (NAB2)-signal transducer and activator of transcription 6 (STAT6) fusion on the biological behavior and the mechanism of acquisition of malignant phenotype in solitary fibrous tumor (SFT) is not well understood. We examined variations of the NAB2-STAT6 fusion gene in 40 cases of SFT using formalin-fixed, paraffin-embedded tissues and secondary genetic alterations of tumor protein p53 (TP53),, platelet-derived growth factor receptor, ? polypeptide (PDGFRB), and telomerase reverse transcriptase (TERT) promoters. These gene variations were compared with the clinicopathological features. The 2-year and 5-year disease-free survival rates (DFSRs) were 91% and 83%, respectively. All 40 samples demonstrated nuclear staining for STAT6, including CD34-negative cases. Moreover, p53-positive staining was associated with a lower DFSR and was significantly associated with higher Ki-67 label index, higher mitotic rate (mitosis, >4/high-power field), and the presence of nuclear atypia/pleomorphism. NAB2-STAT6 fusions were detected in all of the cases; the NAB2 exon 4-STAT6 exon 2, the most common genotype, appeared in 18 cases, which was associated with thoracic tumor location and the less aggressive phenotype. In contrast, tumors with NAB2 exon 6-STAT6 exon 16/18 demonstrated an aggressive phenotype. Mutations in TP53 and PDGFRB were detected in 2 and 3 cases respectively, and these occurred in a mutually exclusive fashion. TERT promoter hot spot mutations were observed in 5 cases, which were associated with shorter DFSR. Two dedifferentiated SFT cases harbored both TP53 and TERT promoter mutations. TP53 mutations, which result in its overexpression, in combination with TERT promoter mutations seem to play an important role in the dedifferentiation process. PMID:25582503

  17. Management of spermatic cord tumors: a rare urologic malignancy.

    Science.gov (United States)

    Rodríguez, Dayron; Olumi, Aria F

    2012-12-01

    Primary spermatic cord tumors are rare yet clinically significant urologic lesions that affect patients of all ages. They are the most common tumors of the paratesticular region and generally present as asymptomatic, slow growing, firm, palpable paratesticular masses. Although most of them are benign comprised primarily of lipomas, approximately 25% are potentially life-threatening malignant tumors. The most common reported malignant histological types include liposarcomas, leiomyosarcomas, rhabdomyosarcomas, malignant fibrous histiocytoma, and fibrosarcomas. Management of these malignant tumors has been difficult because of their rarity, therefore there is little consensus regarding optimal surgical and adjunctive treatment strategies. It is recommended that radiological techniques such as scrotal ultrasound (US), computed tomography, and magnetic resonance be used to evaluate these masses before surgery. The curative treatment of choice is radical orchiectomy with high cord ligation and wide excision of surrounding soft tissue structures within the inguinal canal. Patients with inadequately resected disease should undergo a reoperative procedure for wide inguinal re-resection. Retroperitoneal lymphadenectomy is recommended when there is preoperative evidence of retroperitoneal lymph node metastasis and as an adjuvant treatment for rhabdomyosarcomas since they have a higher propensity for lymphatic spread. Adjuvant treatments, such as radiotherapy and chemotherapy, have shown little efficacy, except in the management of patients with local recurrence or high-grade rhabdomyosarcomas. Long-term follow up is recommended given their high recurrence rates. PMID:23205059

  18. Intrarenal solitary fibrous tumor of the kidney report of a case with emphasis on the differential diagnosis in the wide spectrum of monomorphous spindle cell tumors of the kidney.

    Science.gov (United States)

    Magro, Gaetano; Cavallaro, Vincenzo; Torrisi, Antonietta; Lopes, Maria; Dell'Albani, Marcello; Lanzafame, Salvatore

    2002-01-01

    Solitary fibrous tumor (SFT) is a neoplasm that can occur in the urogenital tract, and is also reported occurring in the spermatic cord, seminal vesicles, urinary bladder, prostate, and kidney. Furthermore, it is most important to consider its existence in the kidney, because it is usually diagnosed as renal cell carcinoma pre-operatively. To our knowledge, only 10 cases of SFT have been reported in the kidney to date. We report the clinico-pathological features of an intrarenal SFT occurring in a 31-year-old woman. The tumor, measuring 8.6 cm in its greatest diameter, completely replaced the cortex and the medulla of the middle region of the right kidney, compressing the pelvis. Radiological imaging was consistent with a renal cell carcinoma. Histologically, the tumor was composed of a proliferation of bland-looking vimentin+, CD34+, bcl2+ and CD99+ spindle cells exhibiting a haphazard to storiform growth pattern, pushing borders, and a low mitotic rate (2 mitoses x 10 HPF). We placed emphasis on the differential diagnostic problems, i.e., its differentiation from other primary monomorphous benign and malignant spindle cell tumors of the kidney, such as fibroma, benign fibrous histiocytoma, hemangiopericytoma, inflammatory myofibroblastic (pseudo-)tumor, leiomyoma, angiomyolipoma with predominant spindle cell smooth muscle component, benign peripheral nerve sheath tumors, renal mixed epithelial/stromal tumors, adult type mesoblastic nephroma, fibrous type monophasic synovial sarcoma, malignant peripheral nerve sheath tumors, fibrosarcoma, and low-grade fibromyxoid sarcoma. PMID:11866209

  19. Benign looking giant cell component in dedifferentiated chondrosarcoma: benign or malignant? A case report.

    Science.gov (United States)

    Huang, Jin; Jiang, Zhiming; Yang, Qingcheng; Zhang, Huizhen

    2013-02-01

    Dedifferentiated chondrosarcomas (DDCS) account for approximately 10% of all chondrosarcoma cases and its 5-year survival is only 10%. The dedifferentiated components of DDCS could be osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. In this article, the authors report a rare case of DDCS in a 19-year-old female, in which the dedifferentiated component showed a close histological resemblance to a giant cell tumor of bone. Radiological diagnosis revealed an expansive osteolytic lesion in the epiphysis of right proximal humerus, which also extended to the diaphysis with irregular calcification and focal cortical breakthrough. The biopsy tissue contained the features of a giant cell tumor of bone and well-differentiated cartilage. Pathological examination revealed a biphasic tumor comprising of low-grade chondrosarcoma and nonchondroid giant cell-rich lesion similar to conventional giant cell tumor of bone, and there is an abrupt transition between the 2 components. PMID:22736299

  20. Cytogenetic and molecular-genetic aberrations in malignant primary bone tumors; Zytogenetische und molekulargenetische Veraenderungen bei boesartigen primaeren Knochentumoren

    Energy Technology Data Exchange (ETDEWEB)

    Zoubek, A.; Kovar, H.; Gadner, H. [St. Anna Kinderspital, Wien (Austria). Forschungsinstitut fuer Krebskranke Kinder

    1998-06-01

    Osteosarcoma, chondrosarcoma and tumors of the Ewing group are the most frequently observed primary malignant bone tumors. In an Internet homepage recently constructed for the Orthopedic Hospital Rizzoli Bologna, Italy, these tumors have represented the majority of 4423 malignant bone tumors in the archives of this institution since 1920 (http://www.tizeta.it/rizzoli). Malignant fibrous histiocytoma, fibrosarcoma, hemangioendothelioma, malignant hemangiopericytoma and giant-cell tumors are diagnosed less frequently. Since the introduction of modern molecular and cytogenic techniques, knowledge of genetic aberrations in malginant bone tumors has steadily increased. However, so far only for the group of Ewing tumors has a recurrent chromosomal marker, the translocation t(11; 22)(q24; q12), been identified. (orig.) [Deutsch] Osteosarkome, Chondrosarkome und Tumoren der Ewing-Gruppe sind die weitaus haeufigsten primaeren boesartigen Knochentumoren. In einer juengst eingerichteten Internet-Homepage des Orthopaedischen Spital Rizzoli in Bolgna, die das Archiv dieser Institution seit dem Jahre 1900 wiedergibt, stellen diese Entitaeten den Grossteil von beobachteten malignen Knochentumoren dar (http://www.tizeta.it/rizzoli). Seltener werden maligne fibroese Histiozytome, Fibrosarkome, Haemangioendotheliome, maligne Hemangioperizytome und Riesenzelltumoren diagnostiziert. Das Wissen ueber genetische Veraenderungen bei malignen Knochentumoren hat in den letzten Jahren durch den breiten Einsatz moderner molekularer und zytogenetischer Techniken stark zugenommen. Bisher konnte jedoch nur fuer Tumoren der Ewing-Gruppe ein konstant nachweisbares genetisches Merkmal identifizert werden, das in einer fuer diese Erkrankung pathognomonischen chromosomalen Translokation t(11; 22)(q24; q12) besteht. (orig.)

  1. Special diagnostic problems in primary malignant bone tumors

    International Nuclear Information System (INIS)

    The diagnosis of primary malignant bone tumors, which only account for 1% of malignancies in humans, represents quite a challange for the pathologist. Apart from the often overlapping morphology between different entities, heterogeneity within one and the same tumor has to be kept in mind. Furthermore, in most cases the diagnosis must be established based on small biopsy specimens and occasionally even on frozen sections. In this context detailed clinical information including the patient's age and exact localization of the tumor, as depicted by X-ray or MRI, are essential requirements for a correct diagnosis. In addition, multiple biopsies from different tumor sites may be of help. For example, 25% of osteogenic sarcomas (OSA) are chondroplastic. Others may contain areas similar to fibrosarcoma (FSA) or malignant fibrous histiocytoma (MFH). Since 90% of OSA occur in the second decade of life whereas chondrosarcomas, FSA and MFH usually manifest after the age of 40 years, a biopsy solely composed of malignant chondromatous tissue obtained from a tibial lesion of a 10-year-old child should most likely be considered as part of an OSA. In the differential diagnosis of the so-called small, round cell tumors, which include Ewing sarcoma, malignant lymphoma and small-cell OSA, immunohistochemical staining of the paraffin-embedded material and a molecular biological/genetic work-up of frozen material are most helpful. In this paper the histomorphological characteristics and he histomorphological characteristics and criteria for differential diagnosis of the most common primary malignant bone tumors are discussed. (orig.)

  2. The Study of the Malignant Tumors of the Maxillary Sinus by Computed Tomography

    International Nuclear Information System (INIS)

    CT findings of proven 25 malignant tumors of the maxillary sinus were retrospectively analyzed to be of help in the diagnosis and treatment. The results were as follow: 1. Average age was 54 years old, and eighteen were males and seven were females with a ratio of 2.6:1. 2. The most common histopathologic feature was squamous cell carcinoma (19 cases) and others were two cases of adenoid cystic carcinoma, one case of malignant fibrous histiocytoma, mucoepidermoid tumor, histiocytic lymphoma, unidentified malignant tumor. 3. CT findings were sinus opacification (4%), soft tissue mass (92%), low densities within soft tissue mass (44%), air densities within soft tissue mass (24%), osteosclerosis (4%), bone destruction (92%), bone displacement (32%), fat plane obliteration(76%). 4. CT in the malignant maxillary sinus tumors approved the value in evaluation of tumor extension to nasal cavity, ethmoid sinus, orbit, infratemporal fossa, pterygopalatine fossa, pterygoid fossa, pterygoid muscle, cheek skin and intracranial cavity. 5. Twenty four cases (96%) were stage III, stage IV according to AJCC TNM classification. 6. Bone findings were destruction, displacement, sclerosis and most frequent site of bone destruction was the medial wall of the antrum (92%). 7. Tumor growth pattern showed destructive pattern in 18 cases (72%), and squamous cell carcinoma showed destructive pattern. (p<0.05).

  3. Diagnostic significance of MRI in malignant skin tumors

    International Nuclear Information System (INIS)

    For surgical treatment of malignant tumors, it is important to clarify the depth and area of invasion of tumors and the relation to surrounding normal tissues such as adipose tissue, muscles and bones in addition to the histological diagnosis of the tumors before operation. For this purpose we clinically evaluated a magnetic resonance imaging (MRI) for diagnosing skin tumors. A MRI, SIGNA (GE), which analyzes the tumors by a spin echo method (TR 1500, TE 20) was used in this study, and 29 slices of MRI in a tumor were accumulated crossing those tumors. The usefulness of three dimensional presentation of skin tumors performed by the MRI data was also discussed. For three dimensional presentation, VoxelflingerTM was applied and those images were compared with cross section of those tumors during operation and histological specimens. We applied the MRI examination on patients with malignant melanoma, malignant fibrous histiocytoma, fibrosarcoma and squamous cell carcinoma of skin. The MRI was a very useful tool to clarify the depth and area of invasion of malignant tumors and the relation to surrounding normal tissues. The effects of MRI was most remarkable when applied on patients with malignant melanoma of soles. Three dimensional presentation obtainned from the MRI data was also useful to know three dimensional condition of those tumors but it seems still to have limitation because of the analytical software of the computer. In conclusion, we suggest that Mcomputer. In conclusion, we suggest that MRI should be the imaging modality of choice in evaluating skin tumors especially of the extremities, and three-dimensional analysis will be beneficial as well as that of using slice images in the future. (author)

  4. Soft tissue giant cell tumour of low malignant potential: a rare tumour at a rare site.

    Science.gov (United States)

    Bhat, Amoolya; V, Geethamani; C, Vijaya

    2013-12-01

    "Soft tissue giant cell tumour of low malignant potential" is considered as the soft tissue counterpart of osteoclastoma of the bone. It is a primary soft tissue tumour which is classified under the category of fibrohistiocytic tumours of intermediate malignancy.Seventy percent of the tumours involve the extremities and only about seven percent of them arise in head and neck region. They are composed of nodules of histiocytes in a vascular stroma, with multinucleated osteoclast-like giant cells positive for vimentin, smooth muscle actin (SMA), CD68 and Tarterate Resistant Acid Phosphatase (TRAP). We are presenting a case of a 75-year-old man who had a nodule on the ala of the nose. Histopathology showed a histiocytic lesion. Benign fibrous histiocytoma, plexiform fibrohistiocytic tumour, solitary reticulohistiocytoma and histioid leprosy were ruled out by using special stains and immunostains. Expression of smooth muscle actin and CD68 confirmed the diagnosis of a soft tissue giant cell tumour with a low malignant potential. PMID:24551690

  5. Malignant tumours of the heart: a review of tumour type, diagnosis and therapy.

    Science.gov (United States)

    Neragi-Miandoab, S; Kim, J; Vlahakes, G J

    2007-12-01

    Primary cardiac neoplasms are rare and occur less commonly than metastatic disease of the heart. In this overview, current published studies concerning malignant neoplasms of the heart are reviewed, together with some insights into their aetiology, diagnosis and management. We searched medline using the subject 'cardiac neoplasms'. We selected about 110 articles from between 1973 and 2006, of which 76 sources were used to complete the review. Sarcomas are the most common cardiac tumours and include myxosarcoma, liposarcoma, angiosarcoma, fibrosarcoma, leiomyosarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, neurofibrosarcoma, malignant fibrous histiocytoma and undifferentiated sarcoma. The classic symptoms of cardiac tumours are intracardiac obstruction, signs of systemic embolisation, and systemic or constitutional symptoms. However, serious complications including stroke, myocardial infarction and even sudden death from arrhythmia may be the first signs of a tumour. Echocardiography and angiography are essential diagnostic tools for evaluating cardiac neoplasms. Computed tomography and magnetic resonance imaging studies have improved the diagnostic approach in recent decades. Successful treatment for benign cardiac tumours is usually achieved by surgical resection. Unfortunately, resection of the tumour is not always feasible. The prognosis after surgery is usually excellent in the case of benign tumours, but the prognosis of malignant tumours remains dismal. In conclusion, there are limited published data concerning cardiac neoplasms. Therefore, a high level of suspicion is required for early diagnosis. Surgery is the cornerstone of therapy. However, a multi-treatment approach, including chemotherapy, radiation as well as evolving approaches such as gene therapy, might provide a better palliative and curative result. PMID:17693068

  6. Prevalence of Malignant Soft Tissue Tumors inExtremities: An Epidemiological Study in Syria

    Directory of Open Access Journals (Sweden)

    Habib Reshadi

    2014-06-01

    Full Text Available Background:   Although the majority of soft tissue masses are benign, it is important to consider malignancy in differential diagnoses. Because most soft tissue sarcomas present as a painless mass, clinicians must watch for signs suggestive of malignancy, including large size, rapid growth, and site deep into the deep fascia.The purpose of this study was to determine the relative prevalence according to sex and age, site of tumor, skeletal distribution, and treatment (surgery, chemotherapy and radiotherapy before and after surgery, and ascertain the relative frequency of these tumors in specific anatomic sites and age groups based on pathological studies. Methods: A total of 308 patients, with a musculoskeletal tumor were evaluated retrospectively. All of the patients enrolled into this study were referred to the Beirouni Hospital of Damascus University with a proven diagnosis of alignant soft tissue tumors from the beginning of January 2008 until the end of 2010. The prevalence of the malignant soft tissue tumors in these patients was analyzed. For purposes of analysis, all lesions were placed in 1 of 9 categories: hand and wrist, forearm, humorous (arm, proximal limb girdle (axilla and shoulder, foot and ankle, thigh, hip and buttocks region, trunk, and other lesions. Age and sex also were recorded. Results: Malignant tumors consisted of seven diagnostic categories: malignant fibrous histiocytoma (23%, liposarcoma (22%, rhabdomyosarcoma (9%, leiomyosarcoma (8%, malignant schwannoma (5%, dermatofibrosarcoma protuberans (5%, synovial sarcoma (10%, fibrosarcoma (13%, extraskeletal chondrosarcoma (1%, and extraskeletal Ewing sarcoma (4%. Conclusions: Despite the multitude of pathologic possibilities, most malignant soft-tissue tumors are classified into a small number of diagnoses. These may be further defined when the site of the lesion and the age of the patient are considered. Knowledge of tumor prevalence will assist radiologists in establishing a suitably ordered differential diagnosis when a soft-tissue tumor has a nonspecific radiologic appearance.    

  7. Highly malignant soft tissue sarcoma of the extremity with a delayed diagnosis

    Directory of Open Access Journals (Sweden)

    Chae In

    2010-09-01

    Full Text Available Abstract Purpose To evaluate the characteristics of highly malignant soft tissue sarcoma of the extremity with a delayed diagnosis. Materials and methods The clinical and radiological characteristics of 18 cases of highly malignant soft tissue sarcomas of the extremity with a delayed diagnosis were determined. Results Ten men and eight women of mean age 44.8 years (range, 15-79 years were included in this study. Seven cases of synovial sarcoma, three cases each of alveolar soft part sarcoma and malignant fibrous histiocytoma, two cases each of highly malignant leiomyosarcoma and myxofibrosarcoma, and one case of clear cell sarcoma were enrolled. Times from tumor detection to diagnosis ranged from 1 to 3 years in most cases; three of the seven synovial sarcoma cases took more than 10 years to diagnose. Of the seven cases of synovial sarcoma, five cases of small, superficial located masses were simply excised without a pre-surgical biopsy. Three cases of alveolar soft part sarcoma showed characteristic T1- and T2-weighted high signal intensities with signal voids in MR images. In addition, one synovial sarcoma patient and one alveolar soft part sarcoma patient showed evidence of calcification on plain radiographs. However, no general characteristic clinical findings were found to be common to the 18 cases. Conclusions Contrary to general expectations, some soft tissue tumors that grow slowly are painless, and those that occur in superficial limbs may be highly malignant. Thus, even when a slow growing, painless superficial mass is encountered in a limb, physicians should keep the possibility of highly malignant soft tissue sarcoma in mind.

  8. Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature / Tumor fibroso solitário maligno da tiroide: relato de caso e revisão da literatura

    Scientific Electronic Library Online (English)

    Wellington, Alves Filho; Renata Regina da Graça Lorencetti, Mahmoud; Daniel Marin, Ramos; Vergilius José Furtado de, Araujo-Filho; Patricia Picciarelli de, Lima; Claudio Roberto, Cernea; Lenine Garcia, Brandão.

    2014-06-01

    Full Text Available O tumor fibroso solitário (SFT) é uma neoplasia rara de células fusiformes que mais frequentemente envolve a pleura, raramente ocorrendo em áreas extratorácicas. Já foram descritos 26 casos de SFT da tiroide. Relatamos o caso de uma paciente de 60 anos de idade com um histórico de 8 meses de aumento [...] do pescoço associado à disfagia. A paciente foi submetida a uma hemitiroidectomia direita e foi diagnosticado um SFT de tiroide. A imuno-histoquímica mostrou resultados positivos para o marcador CD34, e o grande número de mitoses e a presença de atipia celular sugerem que o tumor era maligno. Em nosso conhecimento, este é o segundo caso de STF da tiroide maligno já relatado. Dada a rara ocorrência desses tumores, a indicação de tratamento adjuvante e o prognóstico são incertos. Recomenda-se o acompanhamento de longo prazo depois da ressecção cirúrgica. Abstract in english Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm that most often involves the pleura, rarely occurring in extra-thoracic locations. Twenty-six cases of SFT arising in the thyroid gland have been described. We report a case of a 60-year-old woman presenting an 8-month history of enla [...] rgement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisable.

  9. Fibrous dysplasia of bone: a clinicopathologic review

    Directory of Open Access Journals (Sweden)

    Mohan H

    2011-11-01

    Full Text Available Harsh Mohan1, Preeti Mittal1, Irneet Mundi1, Sudhir Kumar21Department of Pathology, 2Department of Orthopedics, Government Medical College, Sector 32, Chandigarh, IndiaAbstract: Fibrous dysplasia of the bones is an uncommon congenital skeletal disorder that is found equally in both genders and is not inherited. Its etiology has been linked to an activating mutation of Gs? and the downstream effects of the resultant increase in cAMP. Fibrous dysplasia is categorized as either monostotic or polyostotic, and may occur as a component of McCune-Albright syndrome or the rare Mazabraud syndrome. Long bones, skull bones, and ribs are the most commonly affected bones. The radiological picture is somewhat variable, including a ground-glass appearance, expansion of the bone, and sclerosis surrounding the lesion. Histologically, fibrous dysplasia shows irregularly-shaped trabeculae of immature, woven bone in a background of variably cellular, loosely arranged fibrous stroma. It may be complicated by pathologic fracture, and rarely by malignant transformation. This review examines interesting issues surrounding the etiology of fibrous dysplasia, its clinical and laboratory manifestations, radiological picture, utility of bone biopsy, gross and microscopic pathology, complications, and its differential diagnostic considerations.Keywords: fibrous dysplasia, McCune-Albright syndrome, monostotic form, polyostotic form

  10. Pseudotumoral fibrous dysplasia of the maxilla

    International Nuclear Information System (INIS)

    Clinical, radiological, and histological problems arise relating to fibrous dysplasia of the maxilla. Clinically, 11 of our 39 cases developed so rapidly that the lesions were suspected of being malignant. The histological diagnosis may be very difficult, since any tumoural, reactive, or healing process may simulate fibrous dysplasia. As a general rule, the diagnosis is established most easily by the radiological examination. The radiologist's responsibility is important, as mistakes may have serious consequences. We report four pseudotumoural forms of maxillary sinus fibrous dysplasia. All were characterised clinically by rapid evolution, radiologically by opacity of the sinus with apparent destruction of its wall, and histologically by difficulty in establishing the diagnosis. In two cases indeed, the initial histological interpretation was an osteogenic sarcoma. Due to its excellent densitometric resolution, computed tomography provides an invaluable contribution by displaying the fibrous wall of an intact or even thickened maxillary sinus when conventional radiology has suggested a destructive process. In difficult cases of maxillary fibrous dysplasia, computed tomography should be used as a supplementary investigation to establish the correct diagnosis. (orig.)

  11. Steel Fibrous Concrete

    International Science & Technology Center (ISTC)

    The Construction of Reliable and Durable Structural Units for Energy Facilities, Transportation Facilities and Other Structures Subjected to the Action of a Variety of Conditions and Loads Using New Compound Material - Steel Fibrous Concrete

  12. A case of congenital solitary Langerhans cell histiocytoma.

    LENUS (Irish Health Repository)

    Ricciardo, Bernadette

    2012-02-01

    A newborn baby boy was referred to the Paediatric Dermatology Unit with a solitary asymptomatic nodule overlying his right nasolabial fold. Complete physical examination, full blood count, serum chemistry, liver function tests and baseline imaging were unremarkable. Histopathological examination showed an atypical dermal infiltrate of mononuclear cells that stained positive with CD1a and S100. A diagnosis of congenital solitary Langerhans cell histiocytoma was made. The lesion completely resolved by 4 months of age. The baby is now 15 months old and repeat systemic evaluation has remained normal.

  13. Progressive nodular histiocytoma associated with thrombocytopenia with absent radii (TAR syndrome) and angiofibromas.

    Science.gov (United States)

    Rosón, Elena; Flórez, Angeles; Feal, Carlos; De La Torre, Carlos; García-Doval, Ignacio; Abalde, Teresa; Cruces, Manuel

    2006-01-01

    A 50-year-old woman was admitted due to a long-standing history of cutaneous lesions, which were gradually increasing in number and size, located on the trunk and extremities. Histological studies confirmed the initial clinical diagnosis of histiocytomas. Moreover, the patient had numerous smooth erythematous papules on her chin and around her nose, which were diagnosed histologically as angiofibromas. The patient had congenital phocomelia. Analytical and imaging studies revealed the presence of bilateral phocomelia due to absent radii and thrombocytopenia (TAR syndrome). Multiple histiocytomas in a normolipaemic patient bring up several differential diagnoses. Slow progressive evolution without spontaneous resolution and a scattered distribution on the trunk and extremities suggest the diagnosis of progressive nodular histiocytoma. To our knowledge progressive nodular histiocytoma has not been reported previously associated either with TAR syndrome or with angiofibromas. These entities are uncommon, thus their association may not be due to chance. PMID:16874423

  14. Fibrous glass and cancer.

    Science.gov (United States)

    Infante, P F; Schuman, L D; Dement, J; Huff, J

    1994-10-01

    Some argue that fibrous glass (glass wool) should not be considered as a likely human carcinogen and hence should not be listed in the Seventh Annual Report on Carcinogens (ARC) prepared by the National Toxicology Program (NTP) and mandated by the U.S. Congress. In examining this issue, data from both laboratory experiments (animal studies) and epidemiologic studies (human data) are reviewed with the results evaluated according to the criteria established by the International Agency for Research on Cancer (IARC) and adopted in slightly modified form by the NTP for classifying substances as human carcinogens or likely human carcinogens. From our comprehensive review of the available information, we conclude that fibrous glass materials are carcinogenic, and in view of the NTP and IARC definitions should be listed in the ARC. Our review then examines the carcinogenic potency of glass fibers to humans in comparison with asbestos fibers and concludes that on a fiber-per-fiber basis, glass fibers may be as potent or even more potent than asbestos. The implications of these findings are then presented for regulatory purposes in the occupational setting. PMID:7810554

  15. Phenotypic characterisation of peripheral blood lymphoid cells in people exposed to fibrous zeolite.

    OpenAIRE

    Ozesmi, M.; Karlsson-parra, A.; Hillerdal, G.; Forsum, U.

    1986-01-01

    Among inhabitants of the village of Karain in Turkey there is an extremely high incidence of malignant mesothelioma, most probably due to exposure to erionite, which is a fibrous zeolite and similar in appearance and properties to asbestos. This mineral may be found in the dust in the village. To characterise possible disturbances in the immune system of people exposed to fibrous zeolite, a phenotypic characterisation of lymphoid cells in the peripheral blood of 74 immigrants to Sweden from K...

  16. Malignant pleural disease

    Energy Technology Data Exchange (ETDEWEB)

    Bonomo, Lorenzo E-mail: l.bonomo@radiol.unich.it; Feragalli, Beatrice; Sacco, Rocco; Merlino, Biagio; Storto, Maria Luigia

    2000-05-01

    The vast majority of pleural neoplasms invade the pleura secondarily and can be seen in patients with bronchogenic carcinoma, breast cancer, lymphoma, and ovarian or gastric carcinoma. Primary pleural neoplasms are less common, although they have developed notoriety since the up-surge of malignant mesothelioma and the knowledge of its connection to asbestos exposure. Other malignant primary tumors include localized fibrous tumor and pleural liposarcoma. In most patients with diffuse malignant pleural disease the chest radiograph shows pleural effusion with or without pleural thickening. Computed tomography (CT) usually provides precise localization and extent of the disease and may be of value in assessing chest wall and mediastinal involvement. In specific situations, magnetic resonance (MR) may be useful as a problem-solving tool when CT findings of chest wall or diaphragmatic invasion are equivocal or in patients with contraindication to intravenous administration of ionic contrast material.

  17. Solitary fibrous tumor of the pleura.

    Science.gov (United States)

    Marak, Creticus P; Dorokhova, Olena; Guddati, Achuta K

    2013-01-01

    Solitary fibrous tumor of the pleura (SFTP) is a rare tumor of mesenchymal origin which can grow to a large size and present with symptoms of cough and pleuritic chest pain. No specific etiological factors for SFTPs are known and they may grow undetected for several years. These tumors are usually benign and may mimic a variety of malignancies. SFTPs are often detected as peripheral opacities on chest X-ray. Unfortunately, fine needle aspiration rarely provides adequate information for a definitive diagnosis. Imaging with computed tomography provides details about the size and extent of any invasion into adjacent tissues. Surgical resection is the mainstay of treatment, and immunohistochemistry of the resected tumor often provides confirmation of the diagnosis. Some SFTPs have been observed to be malignant, and surgical intervention is often lifesaving. There is no adequate data to support the usage of radiotherapy and chemotherapy in the treatment of SFTPs. This tumor exemplifies malignancies which require surgical resection to preempt worse outcomes. Awareness of their presentation and clinical course may help the clinician provide a prompt referral to the thoracic surgeon for resection. PMID:23576139

  18. Guide to Understanding Fibrous Dysplasia

    Science.gov (United States)

    ... earlychildhood as a result of swelling of the jaw. Also, in some cases it may cause the teeth to separate. how does the disease progress? fibrous dysplasia gets progressively worse frombirth until ...

  19. Radiological features of fibrous mediastinitis

    International Nuclear Information System (INIS)

    Fibrous mediastinitis is a rare disease which raises diagnostic problems. On the basis of two case reports and a review of the literature, the authors recall the various clinical and radiological features and discuss the contribution of various imaging methods

  20. Fibrous dysplasia on the skull.

    Science.gov (United States)

    Sarkar, S; Mazumder, U; Rahman, Km; Azam, Mg

    2008-01-01

    A young rickshaw puller admitted in Neurosurgery ward of Mymensingh Medical College Hospital due to ugly looking skull swelling on right side and iatrogenic ulceration on the postero-superior surface of the swelling. He also mentioned that he was not socially well-excepted and facing difficulty in getting married for that ugly lesion and was very unhappy at that time. CT scan was suggestive of fibrous dysplasia of skull bone and no other abnormalities were present on other part of the body. Then complete excision of the mass was done and fibrous dysplasia was confirmed by histopathological study. Two months after surgery he got married and expressed his happiness. In fibrous dysplasia, normal bone is replaced by fibrous connective tissue with varying degrees of osseous metaplasia. It is a benign disorder of bone commonly seen from childhood to the third decade. Virtually any bone in the body can be affected. Regarding investigations, plain radiography in the first line study. CT may be required to assess complex region such as the spine, pelvis, chest and facial skeleton. Histologically, fibrous dysplasia appears as multiple areas of fibrous tissue contained within islands of bone with evidence of both blastic and clastic activity. PMID:18285733

  1. Determinants of outcome of solitary fibrous tumors of the pleura: an observational cohort study

    OpenAIRE

    Franzen, Daniel; Diebold, Matthias; Soltermann, Alex; Schneiter, Didier; Kestenholz, Peter; Stahel, Rolf; Weder, Walter; Kohler, Malcolm

    2014-01-01

    BACKGROUND Solitary fibrous tumors of the pleura (SFTP) are rare and their long-term outcome is difficult to predict, as there are insufficient data which allow accurate characterization of the malignant variant. Thus the aim of this study was to describe the outcome and possible determinants of malignant behavior of SFTPs. METHODS Data were collected retrospectively from medical records of patients treated at the University Hospital Zurich from 1992 to 2012. Kaplan-Meier and Cox regressio...

  2. Fronto-orbital fibrous dysplasia.

    Science.gov (United States)

    Yavuzer, Reha; Bone, Henry; Jackson, Ian T.

    2000-06-01

    Fibrous dysplasia, which is characterized by a disorganized mixture of fibrous and osseous elements in the affected bones, is a non-neoplastic developmental anomaly caused by an activating mutation. Despite an identical histological pattern, the clinical behavior varies according to the site of involvement. Fronto-orbital lesions behave more aggressively and generally continue to grow during adulthood. During the last 20 years, 32 cases of fronto-orbital fibrous dysplasia have been treated and the results of treatment have been assessed. The indications for surgery were mainly visual deterioration due to optic nerve compression, globe malposition and widespread disease causing gross facial deformity. The treatment of these patients consisted of radical resection of the fibro-osseous tissue, decompression of the optic nerve canal and reconstruction of the resected fronto-orbital areas with either noninvolved bone grafts or with dysplastic bone which was contoured down or, in one case, heated in the sterilizer. Recently, Pamidronate, a bone resorption inhibitor, has been added to the treatment protocol. During follow-up there have been two recurrences, repeat optic nerve decompression has not been required and overall the esthetic results are satisfactory. Fronto-orbital fibrous dysplasia can have a devastating outcome with high recurrence rates and blindness, especially following incomplete resection. A radical and extensive approach to treatment is recommended; this seems to be the best choice as witnessed by the good results achieved in this series. PMID:12045956

  3. [Solitary fibrous tumor of the scalp: a case report].

    Science.gov (United States)

    Tourabi, K; Moussaoui, A; Khaless, A; Achbouk, A; Fejjal, N; Hjira, N; Kettani, F; Ihrai, H

    2008-12-01

    The solitary fibrous tumor is a rare tumor, ubiquitous, mesenchymatous essentially affecting serosal surfaces. The location in the scalp is exceptional. We report a case of tumor in left occipital scalp discovered after recurrence of a tumor initially taken for a lipoma. The motive for consultation was mainly aesthetic. The pathological examination is the main element of diagnosis. The assumption is based on a large lumpectomy and an extended and regular clinical monitoring. The forecast is favourable with a decline of one year. However, relapses may occur in the long-term and there are malignant forms. PMID:18550249

  4. Bone scintigraphy in polyostotic fibrous dysplasia

    Energy Technology Data Exchange (ETDEWEB)

    Wadhwa, S.S.; Mansberg, R.; Fernandes, V.B. [Illawarra Regional Hospital, Wollongong, NSW, (Australia)

    1998-03-01

    Fibrous dysplasia is a benign skeletal disorder of unknown aetiology. Fibrous dysplasia characteristically involves the fibrous replacement of portions of the medullary cavities of a single bone (monostotic) or multiple bones (polyostotic). Bones typically involved include the femurs, tibiae, ribs and maxillae. The polyostotic form may be accompanied by skin pigmentation and endocrine abnormalities (McCune Allbright Syndrome). Radiological findings in fibrous dysplasia are variable, ranging from completely radiolucent to radio-opaque lesions, depending on the amount of fibrous or osseous tissue deposited in the medulla. The most common radiographic finding is that of a ground glass-like semi-opaque lesion. Case reports on scintigraphic manifestation of fibrous dysplasia are scanty. We present radiological and scintigraphic findings of polyostotic fibrous dysplasia in a young male. (authors). 3 refs., 1 fig.

  5. Denosumab Treatment for Fibrous Dysplasia

    OpenAIRE

    Boyce, Am; Chong, Wh; Yao, J.; Gafni, Ri; Kelly, Mh; Chamberlain, Ce; Bassim, C.; Cherman, N.; Ellsworth, M.; Kasa-vubu, Jz; Farley, Fa; Molinolo, Aa; Bhattacharyya, N.; Collins, Mt

    2012-01-01

    Fibrous dysplasia (FD) is a skeletal disease caused by somatic activating mutations of the cAMP-regulating protein, Gs?. These mutations lead to replacement of normal bone by proliferative osteogenic precursors, resulting in deformity, fracture, and pain. Medical treatment has been ineffective in altering the disease course. RANK ligand (RANKL) is a cell surface protein involved in many cellular processes, including osteoclastogenesis, and is reported to be overexpressed in FD-like bone cell...

  6. MR findings of fibrous dysplasia

    Energy Technology Data Exchange (ETDEWEB)

    Jee, Won Hee; Choi, Kyu Ho; Jung, Hyun Seouk; Lee, Eun Jung; Park, Jeong Mi; Kim, Ki Tae; Shinn, Kyung Sub; Lee, Youn Soo [Catholic Univ. College of Medicine, Seoul (Korea, Republic of)

    1996-01-01

    To describe the MR findings of fibrous dysplasia MR images of fibrous dysplasia in 13 pathologically proved cases were retrospectively analyzed regarding the signal intensity, hypointense rind, internal septations, cortical disruption, soft tissue extension, and the pattern of contrast enhancement. All cases showed low signal intensity on T1-weighted images. On T2-weighted images, 8 cases(62%) were hyperintense and 5 cases(38%) hypointense. Hypointense rind was seen in 10 cases(77%), internal septations in 3 cases(23%), and cystic change in 2 cases(15%). Soft tissue extension was observed in four cases(31%) including one case with pathologic fracture. After Gd-DTPA infusion, central contrast enhancement was noted in 8 cases(73%) and peripheral rim enhancement in 3 cases(23). Pathologically, hypointensity on T2-weighted images was due to numerous bony trabeculae. Hypointensity on T1W1 and hyperintensity(62%) or hypointensity(38%) on T2W1 as well as contrast enhancement in fibrous dysplasia depend on degree of cellularity, collagen, cystic and hemorrhagic changes, and bony trabeculae.

  7. MR findings of fibrous dysplasia

    International Nuclear Information System (INIS)

    To describe the MR findings of fibrous dysplasia MR images of fibrous dysplasia in 13 pathologically proved cases were retrospectively analyzed regarding the signal intensity, hypointense rind, internal septations, cortical disruption, soft tissue extension, and the pattern of contrast enhancement. All cases showed low signal intensity on T1-weighted images. On T2-weighted images, 8 cases(62%) were hyperintense and 5 cases(38%) hypointense. Hypointense rind was seen in 10 cases(77%), internal septations in 3 cases(23%), and cystic change in 2 cases(15%). Soft tissue extension was observed in four cases(31%) including one case with pathologic fracture. After Gd-DTPA infusion, central contrast enhancement was noted in 8 cases(73%) and peripheral rim enhancement in 3 cases(23). Pathologically, hypointensity on T2-weighted images was due to numerous bony trabeculae. Hypointensity on T1W1 and hyperintensity(62%) or hypointensity(38%) on T2W1 as well as contrast enhancement in fibrous dysplasia depend on degree of cellularity, collagen, cystic and hemorrhagic changes, and bony trabeculae

  8. Intrathoracic giant solitary fibrous tumor

    Science.gov (United States)

    Aydemir, Bülent; Çelik, Sezai; Okay, Tamer; Do?usoy, Ilgaz

    2013-01-01

    Background Solitary fibrous tumor of the pleura is a rare, usually benign, and slow-growing neoplasm. Complete surgical resection for giant tumor of the pleura is challenging because of poor exposure and a large blood supply. We report the case of a giant hypervascular fibrous tumor that filled nearly the entire left hemithorax and anterior mediastinum, and its preoperative management. Case Report: A 59-year-old woman presented to us with exertional dyspnea and chest pain. A chest radiograph showed the right hemithorax completely opaque and a mediastinal shift to the left hemithorax. A tomography scan of the thorax showed a giant mass that almost completely filled the right hemithorax and compressed the mediastinum to the left. Because of excessive bleeding during dissection, the operation was terminated after a biopsy specimen was obtained. The biopsy was diagnosed as a benign fibrous tumour. A thoracic computed tomography angiogram showed that the mass was supplied by multiple intercostal arteries as well as an aberrant artery that branches off the celiac trunk in the subdiaphragmatic region. Due to the many arteries that needed to be embolized, the final decision was to control the bleeding following resection by inducing total circulatory arrest with the help of cardiopulmonary bypass. The bleeding could not be controlled under cardiopulmonary bypass and the patient’s death was confirmed. Conclusions: We report this case to emphasize the necessity of preoperative embolization; the use of cardiopulmonary bypass and total circulatory arrest is not a valid alternative method to control the bleeding. PMID:23826442

  9. Dedifferentiated chondrosarcoma arising in fibrous dysplasia: A case report and review of the current literature

    Directory of Open Access Journals (Sweden)

    Nicole MD Riddle

    2009-06-01

    Full Text Available Nicole MD Riddle1, Hideko Yamauchi2, Jamie T Caracciolo4, David Johnson2, G Douglas Letson2, Ardeshir Hakam1,3, Prudence V Smith1,2,3, Marilyn M Bui1,2,31Department of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA; 2Department of Sarcoma, 3Department of Anatomic Pathology, 4Department of Radiology, Moffitt Cancer Center, Tampa, FL, USABackground: Fibrous dysplasia is an uncommon bone disease that has rare but clear potential for malignant transformation. The frequency is increased in polyostotic forms, McCune–Albright syndrome, Mazabraud’s syndrome, and previously irradiated sites. Rapidly progressing pain unrelated to trauma is the most concerning symptom. The early radiological features of sarcomatous transformation are moth-eaten or cystic areas of osteolysis, cortical destruction, and gradual formation of a soft tissue mass. The prognosis is unfavorable as most of the cases are in an advanced stage at the time of diagnosis.Methods: This case was diagnosed at a large cancer center in Florida. Pertinent clinical findings were obtained from chart review and inter-departmental consultation.Results: Histopathological examination revealed dysplastic lamellar bone with no osteoblastic rimming and “Chinese letter” shapes, areas composed of lobulated hyaline cartilage with mild to severe nuclear atypia, and areas of poorly differentiated cells with a spindled appearance, consistent with chondrosarcoma arising within fibrous dysplasia.Conclusions: Sarcomatous transformation of fibrous dysplasia is an uncommon occurrence, yet has significant importance for those with the disease. There may be difficulty with diagnosis given the symptoms and radiologic findings of benign fibrous dysplasia. We report a case of chondrosarcoma rising in fibrous dysplasia and review the current literature. This case is of interest due to the fact that the diagnosis of monostotic fibrous dysplasia was first made at the age of 59 and malignant transformation occurred within a decade with no history of trauma or radiation. This is an excellent example of how a change in symptoms without a history of trauma should be alarming to the clinician and warrants a thorough work-up for malignancy. To the best of our knowledge, this represents the second case of dedifferentiated chondrosarcoma within the English literature.Keywords: dedifferentiated chondrosarcoma, fibrous dysplasia, malignant transformation, McCune–Albright syndrome, Mazabraud’s syndrome

  10. Dicty_cDB: Contig-U16053-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Contig-U16053-1 gap included 2619 2 427921 430195 PLUS 41 47 U16053 2 2 3 0 14 4 1 0 5 4 4 1 1 0 ... ca cultivar-gr... 132 8e-29 (Q3V1N1) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 131 1e-28 AF271 ... Homo sapiens c... 125 6e-27 (Q9Y4C4) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 125 6e-27 AC119 ... Patent WO2008... 124 1e-26 (A4IIK1) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 124 2e-26 CR855 ...

  11. Dicty_cDB: Contig-U13904-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Contig-U13904-1 no gap 1821 5 2954750 2952929 MINUS 15 21 U13904 0 0 0 1 5 0 5 0 4 0 0 0 0 0 Sho ... Homo sapiens c... 83 4e-14 (Q9Y4C4) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 83 4e-14 (Q96NW ... a unknown prote... 72 7e-11 (A4IIK1) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 72 7e-11 EU0165 ... e rich repeat c... 69 6e-10 (Q3V1N1) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 69 6e-10 AK1311 ...

  12. Dicty_cDB: Contig-U11472-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Contig-U11472-1 gap included 3633 - - - - 21 34 U11472 0 0 1 1 7 0 1 0 2 3 6 0 0 0 Show Contig-U ... interacting pro... 95 2e-17 (Q3V1N1) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 95 2e-17 (Q5FVI ... ster CG10307 ge... 92 2e-16 (A4IIK1) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 92 2e-16 BC0814 ... ysenteriae WA1,... 87 6e-15 (Q9Y4C4) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 87 6e-15 BC1560 ...

  13. Dicty_cDB: Contig-U09146-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Contig-U09146-1 gap included 1257 2 6691925 6690728 MINUS 1 2 U09146 0 0 0 0 0 1 0 0 0 0 0 0 0 0 ... etersenii serov... 72 5e-11 (A4IIK1) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 72 5e-11 AY7933 ... Homo sapiens c... 64 1e-08 (Q9Y4C4) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 64 1e-08 CT7372 ... rogans serovar ... 61 7e-08 (Q3V1N1) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 61 7e-08 AL6065 ...

  14. Dicty_cDB: Contig-U15670-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available Contig-U15670-1 gap included 2890 1 2385883 2384869 MINUS 13 14 U15670 0 1 1 1 1 1 1 3 1 3 0 0 0 ... ysenteriae WA1,... 57 4e-06 (A4IIK1) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 57 4e-06 AK1323 ... s embryo head c... 57 4e-06 (Q3V1N1) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 57 4e-06 CP0003 ... Homo sapiens c... 55 1e-05 (Q9Y4C4) RecName: Full=Malignant ... fibrous histiocytoma-amplified ... 55 1e-05 AB0222 ...

  15. Fibrous-Ceramic/Aerogel Composite Insulating Tiles

    Science.gov (United States)

    White, Susan M.; Rasky, Daniel J.

    2004-01-01

    Fibrous-ceramic/aerogel composite tiles have been invented to afford combinations of thermal-insulation and mechanical properties superior to those attainable by making tiles of fibrous ceramics alone or aerogels alone. These lightweight tiles can be tailored to a variety of applications that range from insulating cryogenic tanks to protecting spacecraft against re-entry heating. The advantages and disadvantages of fibrous ceramics and aerogels can be summarized as follows: Tiles made of ceramic fibers are known for mechanical strength, toughness, and machinability. Fibrous ceramic tiles are highly effective as thermal insulators in a vacuum. However, undesirably, the porosity of these materials makes them permeable by gases, so that in the presence of air or other gases, convection and gas-phase conduction contribute to the effective thermal conductivity of the tiles. Other disadvantages of the porosity and permeability of fibrous ceramic tiles arise because gases (e.g., water vapor or cryogenic gases) can condense in pores. This condensation contributes to weight, and in the case of cryogenic systems, the heat of condensation undesirably adds to the heat flowing to the objects that one seeks to keep cold. Moreover, there is a risk of explosion associated with vaporization of previously condensed gas upon reheating. Aerogels offer low permeability, low density, and low thermal conductivity, but are mechanically fragile. The basic idea of the present invention is to exploit the best features of fibrous ceramic tiles and aerogels. In a composite tile according to the invention, the fibrous ceramic serves as a matrix that mechanically supports the aerogel, while the aerogel serves as a low-conductivity, low-permeability filling that closes what would otherwise be the open pores of the fibrous ceramic. Because the aerogel eliminates or at least suppresses permeation by gas, gas-phase conduction, and convection, the thermal conductivity of such a composite even at normal atmospheric pressure is not much greater than that of the fibrous ceramic alone in a vacuum.

  16. Stromal myofibroblasts in potentially malignant and malignant lesions of the oral cavity

    Science.gov (United States)

    RODRIGUES, PRISCILA CAMPIONI; DA COSTA MIGUEL, MÁRCIA CRISTINA; DE AQUINO, SIBELE NASCIMENTO; FONSECA, FELIPE PAIVA; SILVA, ALAN ROGER DOS SANTOS; LEME, ADRIANA FRANCO PAES; COLETTA, RICARDO D.

    2015-01-01

    Previous studies have demonstrated that myofibroblasts in the adjacent stroma are involved in the development and progression of malignant tumors. The aim of this study was to investigate the involvement of myofibroblasts in the progression of oral squamous cell carcinomas (OSCCs) by determining myofibroblast density in potentially malignant and malignant oral lesions. A total of 69 potentially malignant oral lesions (leukoplakias with mild, moderate or severe dysplasia), 90 OSCCs (well-, moderately and poorly differentiated), eight oral verrucous carcinomas and 29 fibrous hyperplasias were examined for the presence of myofibroblasts using immunohistochemical detection of isoform ? of smooth muscle actin. Myofibroblasts were not identified in the adjacent stroma of fibrous hyperplasias and potentially malignant oral lesions, whereas 59.8% of the oral carcinomas exhibited myofibroblasts in various densities. The density was significantly higher in moderately and poorly differentiated OSCCs when compared with well-differentiated tumors (P=0.04 and P=0.007, respectively). In verrucous carcinomas, the specific variant of well-differentiated OSCC, stromal myofibroblasts were not detected. The results of the present study demonstrated that immunodetection of myofibroblasts does not aid with the determination of the malignant transformation potential of oral dysplasias, although moderately and poorly differentiated tumors exhibited a significantly higher density of myofibroblasts. The results reinforce the hypothesis that myofibroblasts may contribute to oral tumorigenesis, indicating that verification and monitoring of such may serve as a putative marker of OSCC behavior. PMID:25621035

  17. Isolated fibrous dysplasia of the zygomatic bone.

    Science.gov (United States)

    Demirdöver, Cenk; Sahin, Baris; Ozkan, Heval Selman; Durmu?, Ebru Ulger; Oztan, Hasan Yücel

    2010-09-01

    Fibrous dysplasia is a nonneoplastic, hamartomatous, developmental disease of the bone of obscure etiology. The disease is generally presented as a continuously growing, painless mass at late childhood. It is mostly seen in the maxilla and the mandible in facial skeleton. Involvement of the zygomatic bone is far rarer. Fibrous dysplasia of the zygomatic bone may cause orbital dystopia, diplopia, proptosis, loss of visual acuity, swelling, mass formation, or facial asymmetry. We present 2 cases of fibrous dysplasia with isolated zygomatic bone involvement. PMID:20818245

  18. From the archives of the AFIP: benign fibrous tumors and tumorlike lesions of the mesentery: radiologic-pathologic correlation.

    Science.gov (United States)

    Levy, Angela D; Rimola, Jordi; Mehrotra, Anupamjit K; Sobin, Leslie H

    2006-01-01

    Mesenteric fibromatosis, sclerosing mesenteritis, inflammatory pseudotumor, and extrapleural solitary fibrous tumor constitute a loosely associated group of benign fibrous tumors and tumorlike lesions of the mesentery. These lesions are linked histologically by the presence of fibroblasts or fibrosis and anatomically by their location within the mesentery. Although rare, and distinctly different in pathogenesis and biologic behavior, these fibrous lesions have pathologic and radiologic features that overlap with one another and with more common neoplastic and nonneoplastic lesions of the mesentery. Mesenteric fibromatosis is a locally aggressive, benign proliferative process that may occur sporadically or in association with familial adenomatous polyposis. It most frequently manifests as a focal mesenteric mass and may simulate lymphoma, metastatic disease, or a soft-tissue sarcoma. Sclerosing mesenteritis is a rare idiopathic disorder that most commonly produces a stellate mass within the mesentery and should be differentiated from metastatic disease, specifically metastatic carcinoid, because it frequently responds to conservative or medical management. Inflammatory pseudotumor (inflammatory myofibroblastic tumor) is a benign, chronic inflammatory disorder of unknown cause that manifests as a solid mesenteric mass, indistinguishable from malignancy. Extrapleural solitary fibrous tumor is a tumor of submesothelial origin that is identical to the solitary fibrous tumor of the pleura. When located in the mesentery or peritoneal cavity, extrapleural solitary fibrous tumor has an imaging pattern that must be differentiated from metastatic disease, soft-tissue sarcomas, and other benign and malignant neoplasms of the mesentery and peritoneum. Knowledge of this group of benign fibrous tumors and tumorlike lesions of the mesentery is important in the preoperative evaluation of a mesenteric mass. PMID:16418255

  19. Optical Coherence Tomography and Fibrous Cap Characterization

    OpenAIRE

    Chamie?, Daniel; Wang, Zhao; Bezerra, Hiram; Rollins, Andrew M.; Costa, Marco A.

    2011-01-01

    The pathophysiology of acute coronary syndromes has long been associated with atherosclerotic plaque rupture. Inflammation, thinning, and disruption of the fibrous cap have been implicated with the final processes leading to plaque rupture, but confirmation of these mechanisms of coronary thrombosis in humans has been hampered by the lack of imaging methods with sufficient resolution to resolve fibrous cap characterization and thickness in vivo. Intravascular optical coherence tomography (OCT...

  20. Tissue Engineering with Nano-Fibrous Scaffolds

    OpenAIRE

    Smith, Laura A.; Liu, Xiaohua; Ma, Peter X.

    2008-01-01

    Tissue Engineering is a rapidly evolving field in terms of cell source and scaffold fabrication. As the template for three dimensional tissue growth, the scaffold should emulate the native extracellular matrix, which is nano-fibrous. Currently, there are three basic techniques capable of generating nano-fibrous scaffolding: electrospinning, molecular self-assembly, and thermally induced phase separation. These scaffolds can then be further modified by various three dimensional surface modific...

  1. Aggressive fibrous dysplasia of the maxillary sinus

    International Nuclear Information System (INIS)

    Five of 34 patients (ages 4-21 years), who were subsequently diagnosed histologically as having fibrous dysplasia of the maxillary sinus, rapidly developed soft tissue masses of the malar region over a period of less than 4 months with accompanying pain (2 patients) and nasal obstruction and exophthalmos (2 patients). Each was clinically suspected of having a sarcoma. After resection, all lesions developed regrowth. At histopathologic examination, both initial and recurrent masses proved to be typical fibrous dysplasia. (orig./UWA)

  2. Solitary fibrous tumor of the thyroid gland.

    OpenAIRE

    Babouk, Nasrat L.

    2004-01-01

    ABSTRACT A solitary fibrous tumor is a mesenchymal neoplasm originally described in the pleura. Subsequently, it was found to exist in many extra-pleural sites including the thyroid gland. Herein, we report a case of solitary fibrous tumor of the thyroid gland associated with symptoms of hoarseness of voice in a 45-year-old man. In this report we discuss and illustrate various aspects of this rare tumor including, the gross macroscopic appearance, the histological findings, the immunohisto...

  3. Denosumab Treatment for Fibrous Dysplasia

    Science.gov (United States)

    Boyce, AM; Chong, WH; Yao, J; Gafni, RI; Kelly, MH; Chamberlain, CE; Bassim, C; Cherman, N; Ellsworth, M; Kasa-Vubu, JZ; Farley, FA; Molinolo, AA; Bhattacharyya, N; Collins, MT

    2012-01-01

    Fibrous dysplasia (FD) is a skeletal disease caused by somatic activating mutations of the cAMP-regulating protein, Gs?. These mutations lead to replacement of normal bone by proliferative osteogenic precursors, resulting in deformity, fracture, and pain. Medical treatment has been ineffective in altering the disease course. RANK ligand (RANKL) is a cell surface protein involved in many cellular processes, including osteoclastogenesis, and is reported to be overexpressed in FD-like bone cells. Denosumab is a humanized monoclonal antibody to RANKL approved for treatment of osteoporosis and prevention of skeletal-related events from bone metastases. We present the case of a 9-year-old boy with severe FD who was treated with denosumab for a rapidly expanding femoral lesion. Immunohistochemical staining on a pre-treatment bone biopsy specimen revealed marked RANKL expression. He was started on monthly denosumab, with an initial starting dose of 1 mg/kg and planned 0.25 mg/kg dose escalations every three months. Over seven months of treatment he showed marked reduction in pain, bone turnover markers, and tumor growth rate. Denosumab did not appear to impair healing of a femoral fracture that occurred while on treatment. With initiation of treatment he developed hypophosphatemia and secondary hyperparathyroidism, necessitating supplementation with phosphorus, calcium and calcitriol. Bone turnover markers (BTM) showed rapid and sustained suppression. With discontinuation there was rapid and dramatic rebound of BTM) with CTX (reflecting osteoclast activity) exceeding pre-treatment levels, and accompanied by severe hypercalcemia. In this child, denosumab lead to dramatic reduction of FD expansion and FD-related bone pain. Denosumab was associated with clinically significant disturbances of mineral metabolism both while on treatment and after discontinuation. Denosumab treatment of FD warrants further study to confirm efficacy and determine potential morbidity, as well as to determine the mechanism of RANKL in the pathogenesis of FD and related bone marrow stromal cell diseases. PMID:22431375

  4. Malignant mesothelioma

    Directory of Open Access Journals (Sweden)

    Parker Robert J

    2008-12-01

    Full Text Available Abstract Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis. The exact prevalence is unknown but it is estimated that mesotheliomas represent less than 1% of all cancers. Its incidence is increasing, with an expected peak in the next 10–20 years. Pleural malignant mesothelioma is the most common form of mesothelioma. Typical presenting features are those of chest pain and dyspnoea. Breathlessness due to a pleural effusion without chest pain is reported in about 30% of patients. A chest wall mass, weight loss, sweating, abdominal pain and ascites (due to peritoneal involvement are less common presentations. Mesothelioma is directly attributable to occupational asbestos exposure with a history of exposure in over 90% of cases. There is also evidence that mesothelioma may result from both para-occupational exposure and non-occupational "environmental" exposure. Idiopathic or spontaneous mesothelioma can also occur in the absence of any exposure to asbestos, with a spontaneous rate in humans of around one per million. A combination of accurate exposure history, along with examination radiology and pathology are essential to make the diagnosis. Distinguishing malignant from benign pleural disease can be challenging. The most helpful CT findings suggesting malignant pleural disease are 1 a circumferential pleural rind, 2 nodular pleural thickening, 3 pleural thickening of > 1 cm and 4 mediastinal pleural involvement. Involvement of a multidisciplinary team is recommended to ensure prompt and appropriate management, using a framework of radiotherapy, chemotherapy, surgery and symptom palliation with end of life care. Compensation issues must also be considered. Life expectancy in malignant mesothelioma is poor, with a median survival of about one year following diagnosis.

  5. Malignant Catatonia

    Directory of Open Access Journals (Sweden)

    Ayca Ozkul

    2010-12-01

    Full Text Available Catatonia is a syndrome characterized by mutism, immobility, negativism, stereotypy, mannerisms, echophenomena, perseveration and passive obedience. The underlying causes can be psychiatric or may be associated with general medical status or neurological diseases. Additionally catatonia has two subtypes as malignant and nonmalignant catatonia. Main symptoms of malignant catatonia are hyperthermia and autonomic symptoms such as tachycardia, tachypnea and hyperhidrosis. It is important to make the diagnosis as early as possible for an appropriate medical treatment. Clinicians should be aware of the fatal outcome of the disease.

  6. Hematologic malignancies

    International Nuclear Information System (INIS)

    The principle aim of this book is to give practical guidelines to the modern treatment of the six important hematologic malignancies. Topics considered include the treatment of the chronic leukemias; acute leukemia in adults; the myeloproliferative disorders: polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis/agnogenic myeloid metaplasia; Hodgkin's Disease; non-Hodgkin's lymphoma; and Multiple Myeloma

  7. Hematologic malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Hoogstraten, B.

    1986-01-01

    The principle aim of this book is to give practical guidelines to the modern treatment of the six important hematologic malignancies. Topics considered include the treatment of the chronic leukemias; acute leukemia in adults; the myeloproliferative disorders: polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis/agnogenic myeloid metaplasia; Hodgkin's Disease; non-Hodgkin's lymphoma; and Multiple Myeloma.

  8. Denosumab treatment for fibrous dysplasia.

    Science.gov (United States)

    Boyce, Alison M; Chong, William H; Yao, Jack; Gafni, Rachel I; Kelly, Marilyn H; Chamberlain, Christine E; Bassim, Carol; Cherman, Natasha; Ellsworth, Michelle; Kasa-Vubu, Josephine Z; Farley, Frances A; Molinolo, Alfredo A; Bhattacharyya, Nisan; Collins, Michael T

    2012-07-01

    Fibrous dysplasia (FD) is a skeletal disease caused by somatic activating mutations of the cyclic adenosine monophosphate (cAMP)-regulating protein, ?-subunit of the Gs stimulatory protein (G(s) ?). These mutations lead to replacement of normal bone by proliferative osteogenic precursors, resulting in deformity, fracture, and pain. Medical treatment has been ineffective in altering the disease course. Receptor activator of NF-?B ligand (RANKL) is a cell-surface protein involved in many cellular processes, including osteoclastogenesis, and is reported to be overexpressed in FD-like bone cells. Denosumab is a humanized monoclonal antibody to RANKL approved for treatment of osteoporosis and prevention of skeletal-related events from bone metastases. We present the case of a 9-year-old boy with severe FD who was treated with denosumab for a rapidly expanding femoral lesion. Immunohistochemical staining on a pretreatment bone biopsy specimen revealed marked RANKL expression. He was started on monthly denosumab, with an initial starting dose of 1 mg/kg and planned 0.25 mg/kg dose escalations every 3 months. Over 7 months of treatment he showed marked reduction in pain, bone turnover markers (BTMs), and tumor growth rate. Denosumab did not appear to impair healing of a femoral fracture that occurred while on treatment. With initiation of treatment he developed hypophosphatemia and secondary hyperparathyroidism, necessitating supplementation with phosphorus, calcium, and calcitriol. BTMs showed rapid and sustained suppression. With discontinuation there was rapid and dramatic rebound of BTMs with cross-linked C-telopeptide (reflecting osteoclast activity) exceeding pretreatment levels, accompanied by severe hypercalcemia. In this child, denosumab lead to dramatic reduction of FD expansion and FD-related bone pain. Denosumab was associated with clinically significant disturbances of mineral metabolism both while on treatment and after discontinuation. Denosumab treatment of FD warrants further study to confirm efficacy and determine potential morbidity, as well as to determine the mechanism of RANKL in the pathogenesis of FD and related bone marrow stromal cell diseases. PMID:22431375

  9. Chemically-bound xenon in fibrous silica.

    Science.gov (United States)

    Kalinowski, Jaroslaw; Räsänen, Markku; Gerber, R Benny

    2014-06-21

    High-level quantum chemical calculations reported here predict the existence and remarkable stability, of chemically-bound xenon atoms in fibrous silica. The results may support the suggestion of Sanloup and coworkers that chemically-bound xenon and silica account for the problem of "missing xenon" (by a factor of 20!) from the atmospheres of Earth and Mars. So far, the host silica was assumed to be quartz, which is in contradiction with theory. The xenon-fibrous silica molecule is computed to be stable well beyond room temperature. The calculated Raman spectra of the species agree well with the main features of the experiments by Sanloup et al. The results predict computationally the existence of a new family of noble-gas containing materials. The fibrous silica species are finite molecules, their laboratory preparation should be feasible, and potential applications are possible. PMID:24807740

  10. P53 pseudogene: potential role in heat shock induced apoptosis in a rat histiocytoma

    Directory of Open Access Journals (Sweden)

    Amere Subbarao Sreedhar

    2010-09-01

    Full Text Available The p53 tumor suppressor gene is either non- functional or highly and frequently mutated in majority of cancers. In our study towards understanding cellular adaptations to stress using a rat histiocytic tumor model, we have identified mis-sense mutation in p53 that led to premature termination of translation at the carboxyl-termi- nus. Further, the cDNA isolated from heat stre- ssed cells producing two amplicons with cDNA specific primers (N-terminus suggested occurrence of possible pseudogene(s. A comparative analysis between different tumor cell lines of rat origin and rat genomic DNA using p53 gene specific primers resulted in the amplification of a processed pseudogene and its positive interaction with wild type p53 probe on Southern blot analysis. The genomic DNA sequence analysis, and sequence comparison with cDNA discovered that the processed pseudogene lacks DNA binding domain and nuclear localization signal, however, contains the ribosomal entry and stop signals. Rat genome BLAST analysis of the pesudogene suggested chromosome-18 localization which was in addition to 14, 13, 10, 9 localization of the cDNA. In the interest of unraveling hidden dimensions of p53 tumor suppressor gene, our study explores the probability of p53 functional pseudogenes in rat histiocytoma.

  11. Osteosarcoma of the mandible arising de novo in fibrous dysplasia. Case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Aikaterine TRIANTAFILLIDOU, Konstantinos PSOMADERIS, Fotis IORDANIDIS, Dimitris KARAKASIS

    2012-04-01

    Full Text Available SUMMARY: Introduction: Malignant transformation of fibrous dysplasia is rare, accounting 4% of cases with McCune-Albright syndrome and 0,5% of monostotic type.Case presentation: An 11-year old boy presented with hard swelling and disfigurement of his mandible in conjunction with alterations of his dental occlusion. Following biopsy, fibrous dysplasia was diagnosed. The patient underwent surgical contouring of the affected bone. Four years later a fast growing mass developed at the same site of the operated mandible. After an incisional biopsy the diagnosis of low-grade osteosarcoma was established. The patient underwent wide mandibulectomy and reconstruction of the defect with bonegraft and is free of the disease for the last 14 years.Conclusion: Most cases of malignant transformation of FD are associated with irradiation of the fibrous dysplasia.The spontaneous transformation of the monostotictype is extremely rare. The development of a soft tissue mass or elevation of serum alkaline phosphatase in a patient with fibrous dysplasia should be considered alarming features and require further investigation to exclude sarcoma.

  12. Epithelioid fibrous papule - a new variant.

    Science.gov (United States)

    Kucher, Cynthia; McNiff, Jennifer M

    2007-07-01

    Fibrous papules (FPs) are common benign lesions occurring most frequently on the nose. Multiple variants have been described, including classic, hypercellular, clear cell, pigmented, pleomorphic, inflammatory and granular FPs. We describe a group of FPs with characteristics that do not easily fit into any of the above categories, with diffuse sheets of distinctive epithelioid cells, causing potential diagnostic confusion. Immunoperoxidase stains show that the cells of this 'epithelioid fibrous papule' are reactive for procollagen, and are negative for NKI/C3, unlike previously described clear cell variants. PMID:17576337

  13. A case of polyostotic fibrous dysplasia

    International Nuclear Information System (INIS)

    Authors have experienced a case of polyostotic fibrous dysplasia and the case is reported in this papey with a review of the literature. A 24 year old male, R. O. K. army private, seen at the 3rd Army Hospital in 1966, with multiple bony involvement of ribs, pelvis, both femurs, tibias, left fibula, metatarsal bones, right humerus and radius, which revealed characteristic 'fibro-cystic appearance' and partial sclerotic changes. The blood chemistry showed moderately elevated serum alkaline phosphatase and slightly elevated calcium level. The bone biopsy taken at rib and iliac bone revealed typical appearance of fibrous dysplasia

  14. Enzymes in bast fibrous plant processing.

    Science.gov (United States)

    Kozlowski, Ryszard; Batog, Jolanta; Konczewicz, Wanda; Mackiewicz-Talarczyk, Maria; Muzyczek, Malgorzata; Sedelnik, Natalia; Tanska, Bogumila

    2006-05-01

    The program COST Action 847 Textile Quality and Biotechnology (2000-2005) has given an excellent chance to review the possibilities of the research, aiming at development of the industrial application of enzymes for bast fibrous plant degumming and primary processing. The recent advancements in enzymatic processing of bast fibrous plants (flax, hemp, jute, ramie and alike plants) and related textiles are given. The performance of enzymes in degumming, modification of bast fibres, roving, yarn, related fabrics as well as enzymatic bonding of lignocellulosic composites is provided. PMID:16791732

  15. Mobybdenum (6) determination in seawater after preconcentration on fibrous sorbent

    International Nuclear Information System (INIS)

    A technique has been developed for photometric molybdenum determination in seawater using fibrous sorbent for preconcentration. The determination limit is 4 ?g/l. A possibility of water sample preservation by means of fibrous sorbent is shown

  16. Extraction of uranium from seawater by the fibrous composite adsorbent

    International Nuclear Information System (INIS)

    The fibrous composite adsorbents consisting of hydrous titanium oxide and activated carbon were prepared with hydrophilic polyacrylonitrile system polymer as a binder under various conditions, and the adsorptive property of the fibrous composite adsorbents for uranium from seawater was examined. The fibrous composite adsorbents which spun under high pressure (10 kg/cm2) was the finest having the largest pore volume. In addition, the amount of uranium adsorbed of the fibrous adsorbent was the largest. The rate of uranium adsorption by the fibrous adsorbent was the same as the rate of uranium adsorption by the powdery adsorbent. The excellent fibrous adsorbent adsorbed 0.23 mg U/g adsorbent for 10 d and 0.65 mg U/g adsorbent for 100 d. The rate of uranium desorption from the fibrous adsorbent by alkali carbonate solution was large, and the uranium in the fibrous adsorbent desorbed 75 % for 8 h and about 100 % for 24 h. (author)

  17. Malignant hyperthermia

    OpenAIRE

    Pollock Neil; James Danielle; Davis Mark; Rosenberg Henry; Stowell Kathryn

    2012-01-01

    Abstract Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stresses such as vigorous exercise and heat. The incidence of MH reactions ranges from 1:5,000 to 1:50,000–100,000 anesthesias. However, the prevalence of the genetic abnormalities may be as great as one in ...

  18. Monostotic fibrous dysplasia of the clivus: MRI and CT findings

    Energy Technology Data Exchange (ETDEWEB)

    Sirvanci, M.; Karaman, K.; Onat, L.; Duran, C.; Ulusoy, O.L. [Department of Diagnostic Radiology, University of Kadir Has Medical School, Istanbul (Turkey)

    2002-10-01

    Fibrous dysplasia is a developmental disorder caused by abnormal proliferation and maturation of fibroblasts resulting in replacement of mature bone by structurally weak, immature woven bone. Clival involvement in monostotic fibrous dysplasia is extremely unusual, and has rarely been reported previously. We report a case of monostotic fibrous dysplasia of the clivus with special emphasis on the imaging findings and differential diagnosis. (orig.)

  19. Monostotic fibrous dysplasia of the clivus: MRI and CT findings

    International Nuclear Information System (INIS)

    Fibrous dysplasia is a developmental disorder caused by abnormal proliferation and maturation of fibroblasts resulting in replacement of mature bone by structurally weak, immature woven bone. Clival involvement in monostotic fibrous dysplasia is extremely unusual, and has rarely been reported previously. We report a case of monostotic fibrous dysplasia of the clivus with special emphasis on the imaging findings and differential diagnosis. (orig.)

  20. History Of Impregnation Techniques With Fibrous Materials

    International Nuclear Information System (INIS)

    The importance of wood as a raw material is described and its deficiencies are listed. The history of the development of some impregnatio processes for fibrous materials is outlined and a hopeful prognosis for the future utilization of improved wood is made. (author)

  1. Development of oxide fibrous monolith systems.

    Energy Technology Data Exchange (ETDEWEB)

    Goretta, K. C.

    1999-03-02

    Fibrous monolithic ceramics generally have a cellular structure that consists of a strong cell surrounded by a weaker boundary phase [1-5]. Fibrous monoliths (FMs) are produced from powders by conventional ceramic fabrication techniques, such as extrusion [1,2]. When properly engineered, they exhibit fail gracefully [3-5]. Several compositions of ceramics and cermets have been processed successfully in fibrous monolithic form [4]. The most thoroughly investigated fibrous monolith consists of Si{sub 3}N{sub 4} cells and a BN cell-boundary phase [3-5]. Through appropriate selection of initial powders and extrusion and hot-pressing parameters, very tough final products have been produced. The resultant high toughness is due primarily to delamination during fracture along textured platelike BN grains. The primary objectives of our program are to develop: (1) Oxide-based FMs, including new systems with improved properties; (2) FMs that can be pressureless sintered rather than hot-pressed; (3) Techniques for continuous extrusion of FM filaments, including solid freeform fabrication (SFF) for net-shape fabrication of FMs; (4) Predictive micromechanical models for FM design and performance; and (5) Ties with industrial producers and users of FMs.

  2. Dedifferentiated chondrosarcoma arising in fibrous dysplasia: A case report and review of the current literature

    OpenAIRE

    Md, Nicole Riddle; Hideko Yamauchi; Caracciolo, Jamie T.; David Johnson; et al.

    2009-01-01

    Nicole MD Riddle1, Hideko Yamauchi2, Jamie T Caracciolo4, David Johnson2, G Douglas Letson2, Ardeshir Hakam1,3, Prudence V Smith1,2,3, Marilyn M Bui1,2,31Department of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA; 2Department of Sarcoma, 3Department of Anatomic Pathology, 4Department of Radiology, Moffitt Cancer Center, Tampa, FL, USABackground: Fibrous dysplasia is an uncommon bone disease that has rare but clear potential for malignant transformation. The...

  3. AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma

    Science.gov (United States)

    2013-05-07

    Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Rhabdomyosarcoma; Dermatofibrosarcoma Protuberans; Endometrial Stromal Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Uterine Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage III Uterine Sarcoma; Stage IV Adult Soft Tissue Sarcoma; Stage IV Uterine Sarcoma; Uterine Carcinosarcoma; Uterine Leiomyosarcoma

  4. Sorafenib in Treating Patients With Metastatic, Locally Advanced, or Recurrent Sarcoma

    Science.gov (United States)

    2014-05-07

    Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Leiomyosarcoma; Adult Malignant Fibrous Histiocytoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Ovarian Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Uterine Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage III Uterine Sarcoma; Stage IV Adult Soft Tissue Sarcoma; Stage IV Uterine Sarcoma; Uterine Carcinosarcoma; Uterine Leiomyosarcoma

  5. Protein (Viridiplantae): 356561015 [

    Lifescience Database Archive (English)

    Full Text Available XP_003548781.1 33090:6225 35493:6825 131221:6825 3193:6825 58023:2414 78536:2269 58024:2269 3398 ... 14:2335 163735:1272 3846:1272 3847:1272 PREDICTED: malignant ... fibrous histiocytoma-amplified sequence 1-like Gly ...

  6. Protein (Viridiplantae): 356531327 [

    Lifescience Database Archive (English)

    Full Text Available XP_003534229.1 33090:6225 35493:6825 131221:6825 3193:6825 58023:2414 78536:2269 58024:2269 3398 ... 14:2335 163735:1272 3846:1272 3847:1272 PREDICTED: malignant ... fibrous histiocytoma-amplified sequence 1-like Gly ...

  7. Malignant mesothelioma.

    Science.gov (United States)

    Kao, S C-H; Reid, G; Lee, K; Vardy, J; Clarke, S; van Zandwijk, N

    2010-11-01

    Malignant mesothelioma (MM) is an aggressive tumour that commonly affects the mesothelial surfaces of the pleural and peritoneal cavities, and occasionally, the tunica vaginalis and the pericardium. Formerly a rare tumour, MM is increasing in incidence in Australia due to the heavy nationwide use of asbestos from 1940 until the 1980s. The incidence is expected to peak in Australia in the next decade, mirroring the long latency period between asbestos exposure and development of MM. Diagnosis of MM can be difficult. Definitive pathological diagnosis is required and it often requires an experienced pathologist to differentiate MM from other benign or malignant processes. Treatment of MM requires a multidisciplinary approach, regardless of palliative or curative intent. Treatment options, such as surgery, chemotherapy, radiotherapy and active symptom control or a combination of these, may be used. Further research is needed to advance the therapeutic options for MM, and strategies to realize personalisation of therapy through discovery of predictive markers. In the Australian society where asbestos contamination of the built environment is very high, education and stringent public health measures are required to prevent a second wave of increased MM incidence. PMID:20298508

  8. Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Haris S Vasiliadis

    2013-01-01

    Full Text Available We report a case of a 32 year-old male, admitted for a lytic lesion of the distal femur. One month after the first X-ray, clinical and imaging deterioration was evident. Open biopsy revealed fibrous dysplasia. Three months later, the lytic lesion had spread to the whole distal third of the femur reaching the articular cartilage. The malignant clinical and imaging features necessitated excision of the lesion and reconstruction with a custom-made total knee arthroplasty. Intra-operatively, no obvious soft tissue infiltration was evident. Nevertheless, an excision of the distal 15.5 cm of the femur including 3.0 cm of the surrounding muscles was finally performed. The histological examination of the excised specimen revealed central low-grade osteosarcoma. Based on the morphological features of the excised tumor, allied to the clinical findings, the diagnosis of low-grade central osteosarcoma was finally made although characters of a fibrous dysplasia were apparent. Central low-grade osteosarcoma is a rare, well-differentiated sub-type of osteosarcoma, with clinical, imaging, and histological features similar to benign tumours. Thus, initial misdiagnosis is usual with the condition commonly mistaken for fibrous dysplasia. Central low-grade osteosarcoma is usually treated with surgery alone, with rare cases of distal metastases. However, regional recurrence is quite frequent after close margin excision.

  9. Large ulcerated cecal lipoma mimicking malignancy

    Directory of Open Access Journals (Sweden)

    Xuchen Zhang

    2010-07-01

    Full Text Available Colonic lipomas are relatively uncommon tumors of mesenchymal origin, composed of well-differentiated adipose tissue supported by fibrous tissue, that usually occur in cecum and ascending colon. Colonic lipomas rarely cause symptoms and are usually detected incidentally. However, if the lesion is large, it may produce symptoms, such as abdominal pain, rectal bleeding, obstruction, intussusception, and even weight loss. Large colonic lipomas can be mistaken for malignancy, which may result in extensive surgical operations. We report a large broad-based ulcerated cecal lipoma in a 68-year-old woman, who presented with abdominal pain and weight loss. The ulcerated lesion was highly suspicious for malignancy radiologically and endoscopically. The patient underwent laparoscopic right-hemicolectomy, and the lesion was diagnosed as a cecal submucosal lipoma. The surgical approach remains the treatment of choice for large and complicated cases.

  10. Fibrous Hamartoma of Infancy, Report of Two Cases

    Directory of Open Access Journals (Sweden)

    Ahmad Bazrafshan

    2008-05-01

    Full Text Available Objective: Fibrous hamartoma of infancy (FHI is a rare, benign soft tissue tumor that typically occurs within the first two years of life. It has a specific histologic appearance comprising of three different mesenchymal tissues with variable proportions in an organoid fashion. The clinical course is typically benign with excellent prognosis. We report two cases of this rare lesion and review its cilinicopathologic characteristics. Case(s Presentation: The first case was a 15-month-old girl who had a subcutaneous mass in the right axillary region and the other one was an 18-month-old boy with a mass on the medial surface of his right ankle. The masses were successfully excised. After 6 and 30 months follow up no recurrence occurred. Conclusion: Although the clinical and imaging findings of FHI are quite similar to those of malignant soft tissue tumor, histologic characteristics of this tumor will guide to the definite diagnosis that will prevent aggressive and mutilating procedures.

  11. Intramuscular myxoma and fibrous dysplasia of bone - Mazabraud's syndrome

    International Nuclear Information System (INIS)

    We present a case of Mazabroud's syndrome, a rare benign disease, with multiple intramuscular myxomas of the thoracic wall associated with fibrous dysplasia of bone. CT, MR imaging and ultrasonography (US) of the thorax showed 2 well circumscribed homogeneous intramuscular tumors. A US-guided needle biopsy with a large-core needle (2.0 mm) and a fine needle (0.8 mm) showed that the tumors were intramuscular myxomas with no sign of malignancy. 99mTc bone scintigraphy showed a markedly increased uptake in the right lower skull, and multiple smaller foci. CT of the skull revealed a right-sided unilateral bone thickening of the orbit and the ethomoidal cells, and right-sided exophthalmia. This case history suggests that patients with multiple intramuscular myxomas should be preoperatively examined for osseous lesions. A postoperative follow-up should also be performed to detect other soft-tissue myxomas not as yet clinically detectable, or rare osseous complications. (orig.)

  12. A case of solitary fibrous tumor arising from the palatine tonsil.

    Science.gov (United States)

    Kanazawa, Takeharu; Kodama, Kozue; Nokubi, Mitsuhiro; Gotsu, Kazuo; Shinnabe, Akihiro; Hasegawa, Masayo; Kusaka, Gen; Iino, Yukiko

    2015-03-01

    Solitary fibrous tumor (SFT) is a distinctive, relatively uncommon soft-tissue neoplasm that usually arises from the pleura. It occurs at various sites; head and neck lesions are very rare. While most of these tumors have a benign course, a small number have malignant potential. We describe a rare case of SFT arising from the left palatine tonsil in a 66-year-old Japanese woman. The mass was completely resected. Immunohistochemical studies were strongly positive for CD34 and bcl-2, mildly positive for phosphorylated protein kinase B and phosphorylated extracellular signal-regulated kinase 1/2, and negative for platelet-derived growth factor receptor alpha and p53. These findings suggested that this tumor was benign. The patient showed no evidence of recurrence during 2 years of follow-up. We believe that the candidate prognostic marker should be checked to distinguish malignant from benign SFTs. PMID:25738718

  13. Nonlinear mechanics of soft fibrous materials

    CERN Document Server

    Ogden, Raymond

    2015-01-01

    The book presents a state-of-the-art overview of the fundamental theories, established models and ongoing research related to the modeling of these materials. Two approaches are conventionally used to develop constitutive relations for highly deformable fibrous materials. According to the phenomenological approach, a strain energy density function can be defined in terms of strain invariants. The other approach is based on kinetic theories, which treats a fibrous material as a randomly oriented inter-tangled network of long molecular chains bridged by permanent and temporary junctions. At the micro-level, these are associated with chemical crosslinks and active entanglements, respectively. The papers include carefully crafted overviews of the fundamental formulation of the three-dimensional theory from several points of view, and address their equivalences and differences. Also included are solutions to boundary-value problems which are amenable to experimental verification. A further aspect is the elasticity...

  14. First description of Phanerozoic radiaxial fibrous dolomite

    Science.gov (United States)

    Richter, D. K.; Heinrich, F.; Geske, A.; Neuser, R. D.; Gies, H.; Immenhauser, A.

    2014-05-01

    The petrographic analysis and crystallographic analysis of concretionary carbonate cements ("coal balls") from Carboniferous paralic swamp deposits reveal the presence of (length fast) radiaxial fibrous dolomite (RFD), a fabric not previously reported from the Phanerozoic. This finding is of significance as earlier reports of Phanerozoic radiaxial fibrous carbonates are exclusively of calcite mineralogy. Dolomite concretions described here formed beneath marine transgressive intervals within palustrine coal seams. This is of significance as seawater was arguably the main source of Mg2 + ions for dolomite formation. Here, data from optical microscopy, cathodoluminescence, electron backscattered diffraction, X-ray diffraction and geochemical analyses are presented to characterize three paragenetic dolomite phases and one calcite phase in these concretions. The main focus is on the earliest diagenetic, non-stoichiometric (degree of order: 0.41-0.46) phase I, characterized by botryoidal dolomite constructed of fibres up to 110 ?m wide with a systematic undulatory extinction and converging crystal axes. Petrographic and crystallographic evidence clearly qualifies phase I dolomite as radiaxial fibrous. Conversely, fascicular optical fabrics were not found. Carbon-isotope ratios (?13C) are depleted (between - 11.8 and - 22.1‰) as expected for carbonate precipitation from marine pore-fluids in organic-matter-rich, paralic sediment. Oxygen isotope (?18O) ratios range between - 1.3 and - 6.0‰. The earliest diagenetic nature of these cements is documented by the presence of ubiquitous, non-compacted fossil plant remains encased in phase I dolomite as well as by the complex zoned luminescence patterns in the crystals and is supported by crystallographic and thermodynamic considerations. It is argued that organic matter, and specifically carboxyl groups, reduced thermodynamic barriers for dolomite formation and facilitated Mg/CaCO3 precipitation. The data shown here reveal a hitherto unknown level of complexity with respect to radiaxial fibrous carbonates and are of importance for those concerned with dolomite and carbonate petrography in general.

  15. Toughened uni-piece fibrous insulation

    Science.gov (United States)

    Leiser, Daniel B (inventor); Smith, Marnell (inventor); Churchward, Rex A. (inventor); Katvala, Victor W. (inventor)

    1992-01-01

    A porous body of fibrous, low density silica-based insulation material is at least in part impregnated with a reactive boron oxide containing borosilicate glass frit, a silicon tetraboride fluxing agent and a molybdenum silicide emittance agent. The glass frit, fluxing agent and emittance agent are separately milled to reduce their particle size, then mixed together to produce a slurry in ethanol. The slurry is then applied to the insulation material and sintered to produce the porous body.

  16. Spontaneous fibrous histiocytic neoplasms in rats.

    OpenAIRE

    Greaves, P.; Faccini, J. M.

    1981-01-01

    A total of 85 spontaneous rat fibrohistiocytic tumours were evaluated histologically and assessed for the presence or absence of metastases. The overall incidence in controls from 2-year carcinogenicity studies was 2.7%. The tumours occurred principally in the subcutaneous and deep soft tissues, and generally appeared after 18 months of age. Four histological types were recognized: histiocytic (17%), pleomorphic (33%), cellular (17%) and very fibrous (33%). Histiocytic tumours were highly mal...

  17. Cutaneous changes in fibrous hamartoma of infancy

    OpenAIRE

    F-eire, Pilar; Fojon, Joaquin Gonzalez-carrero

    2013-01-01

    Only a few published case of fibrous hamartoma of infancy (FHI) have commented on the changes in the overlying skin. There are descriptions of individual cases with cutaneous hyperpigmentation, hypertrichosis and hyperhidrosis. It is interesting to describe our case because, to our knowledge, the altered pigmentation of the overlying skin, with hairs on the surface, and eccrine gland hyperplasia combined with abortive hair follicles has not been reported together in association with the FHI. ...

  18. Fibrous lung tumor: a peculiar case

    OpenAIRE

    Barrettara, Barbara; Napoli, Gaetano; Lacitignola, Angelo; Sardelli, Paolo

    2013-01-01

    Solitary fibrous tumor (SFT) of the pleura and the lung is an uncommon spindle cell neoplasm arising from the visceral pleura in the majority of the cases. However there are some extrapleural sites including the lung. Current considerations were raised by a peculiar recent case: an 81-year-old female, no smoker, presented with undefined left thoracic pain. Radiographic findings of a large solid lung mass (10 cm × 9 cm). Computed tomography (CT) confirmed the thoracic mass showing characteris...

  19. ["Malignant" ARDS].

    Science.gov (United States)

    Metzelder, S K; Reinke, C; Walthers, E M; Barth, P; Vogelmeier, C; Neubauer, A; Bals, R

    2009-10-01

    Acute respiratory failure and the "acute respiratory distress syndrome" (ARDS) are frequent medical conditions in critically ill patients. Various causes can potentially result in the development of ARDS. Two cases are presented, in which malignant diseases were identified as causes of the respiratory failure. The first patient was diagnosed with an acute myeloic leukemia M5 (FAB). In the second patient, lung histology revealed an adenocarcinoma of the lung. These case reports show that in addition to the classical causes of ARDS, specific disease entities can mimic this form of respiratory failure. Beside solid cancers and lymphomas, acute and progressive forms of inflammatory, parenchymal lung diseases (such as acute interstitial pneumonitis, acute eosinophilic pneumonia, diffuse alveolar hemorrhagia, and acute hypersensitivity pneumonitis) can manifest with this picture. As a consequence, the diagnostic workup of respiratory failure of unknown cause should include these entities. PMID:19562262

  20. Primary Malignant Teratoma with a Primitive Neuroectodermal Tumor Component in Thyroid Gland : A Case Report

    OpenAIRE

    Kim, Eunyoung; Bae, Tae Seok; Kwon, Youngmee; Kim, Tae Hyun; Chung, Ki-wook; Kim, Sun Wook; Ro, Jungsil; Lee, Eun Sook

    2007-01-01

    Teratomas comprise the most common extragonadal germ cell tumors in childhood. Most teratomas involving the thyroid are benign and occur in children. However, the adult cases reported are mostly malignant and commonly arise in the thyroid. We report a case of a 31-yr-old female with a huge neck mass. Pathologic examination revealed it to be malignant teratoma composed of primitive neuroepithelial tissue with primitive neural tubes and loose myxoid to fibrous immature mesenchymal stroma. The p...

  1. A Case of Extensive polyostotic fibrous dysplasia

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Do [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Hwang, Eui Hwan; Lee, Sang Rae [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Kyunghee University, Seoul (Korea, Republic of)

    2000-06-15

    Fibrous dysplasia is a benign disorder of bone consisting of intramedullary proliferation of fibrous tissue and irregularly distributed, poorly developed bone. The disease manifests itself in the monostotic form in which only one bone is involved and the polyostotic form in which multiple bones at different sites are affected. We reported a extensive case of polyostotic fibrous dysplasia with involvement of craniofacial bones, mandible, ribs, extremities. A 18-year-old man showed remarkable right facial swelling who had been treated on right femur 3 years ago with a bone graft for pathologic fracture and he recognized facial swelling 5 years ago. Extraoral radiograms and computed tomogram showed diffuse sclerosis with a ground glass appearance of the most calvarial bones, facial bones. The right mandibular lesion showed very expansible lesion with mottled appearance. Bone scans showed multifocal increased uptakes in craniofacial bones, right mandible, bilaterally in ribs, humerus, femur, tibia and characteristic various deformity of right femur (shepherd's crook deformity). This case showed exceptionally bilateral, extensive nature of bone lesion and didn't show any features of skin pigmentation and endocrine disturbances.

  2. Treatment Options for Malignant Mesothelioma

    Science.gov (United States)

    ... Dictionary Search for Clinical Trials NCI Publications Español Malignant Mesothelioma Treatment (PDQ®) Treatment Options for Malignant Mesothelioma Localized Malignant Mesothelioma (Stage I) If malignant ...

  3. Rapid onset of cutaneous angiosarcoma after radiotherapy for breast carcinoma

    International Nuclear Information System (INIS)

    Malignant neoplasms known to develop following external beam radiation include squamous cell carcinoma, osteosarcoma, chondrosarcoma, malignant fibrous histiocytoma, mixed mullerian tumors, malignant schwannoma, myelogenous leukemia and angiosarcoma. Latency periods of many years characterize the onset of these tumors following the exposure. Cutaneous angiosarcoma following radiotherapy for breast carcinoma has been rarely documented, occurring up to 13 years postirradiation. Two cases of this entity are reported occurring 37 months postradiotherapy at the site of mastectomy performed for mammary duct carcinoma

  4. Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma

    Science.gov (United States)

    2014-08-26

    Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Rhabdomyosarcoma; Adult Synovial Sarcoma; Gastrointestinal Stromal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Adult Soft Tissue Sarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

  5. Neuroleptic Malignant Syndrome

    Science.gov (United States)

    ... Enhancing Diversity Find People About NINDS NINDS Neuroleptic Malignant Syndrome Information Page Table of Contents (click to ... being done? Clinical Trials Organizations What is Neuroleptic Malignant Syndrome? Neuroleptic malignant syndrome is a life-threatening, ...

  6. Solitary fibrous tumor of the liver: report of two cases and review of the literature.

    Science.gov (United States)

    Debs, Tarek; Kassir, Radwan; Amor, Imed Ben; Martini, Francesco; Iannelli, Antonio; Gugenheim, Jean

    2014-12-01

    A solitary fibrous tumor (SFT) of the liver is a rare neoplasm of mesenchymal origin. 59 cases have been reported in the literature. We report 2 patients who presented with a hepatic solitary fibrous tumor. The first case is a 65-year-old man who presented with an accidental finding of a large mass in the left liver. Biopsy revealed an SFT and left hepatectomy was performed. The diagnosis was confirmed by histopathology. The second case is an 87-year-old woman who presented with disturbances in her liver function tests. A Computed Tomography (CT) scan showed a large mass in the right liver. Surgery was contraindicated because of the patient's poor general condition. A biopsy was done and SFT was diagnosed histopathologically. SFT are usually benign but the risk of malignant transformation always exists, which mandates surgical resection as the optimal management of these tumors. However, because of the small sample size and the rarity of the entity, it is difficult to define the evolution, the risk factors and the malignant potential of these tumors. PMID:25448647

  7. Solitary fibrous tumor of the adrenal gland: a case report

    International Nuclear Information System (INIS)

    Solitary fibrous tumor is a rare mesenchymal tumor, usually involving the pleura. Its occurrence in various organs of the body has recently been described; in particular, two cases of solitary fibrous tumor of the adrenal gland have been reported worldwide, but no case has been reported in Korea. We describe a case solitary fibrous tumor occurring in the left adrenal gland and discovered incidentally at CT

  8. Solitary fibrous tumor of the adrenal gland: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Paeng, Mi Hye; Kim, Do Youn; Kang, Byung Chul; Baek, Seong Yon [Ewha Wonans University College of Medicine, Seoul (Korea, Republic of)

    2002-08-01

    Solitary fibrous tumor is a rare mesenchymal tumor, usually involving the pleura. Its occurrence in various organs of the body has recently been described; in particular, two cases of solitary fibrous tumor of the adrenal gland have been reported worldwide, but no case has been reported in Korea. We describe a case solitary fibrous tumor occurring in the left adrenal gland and discovered incidentally at CT.

  9. Unusual presentation of monostatic fibrous dysplasia in zygoma.

    Science.gov (United States)

    Verma, Ajay; Jindal, Naveen; Singh, Virendra; Sethi, Preeti

    2013-11-01

    Fibrous dysplasia is a nonneoplastic, developmental disease of the bone that begins in childhood with obscure etiology. Clinically, it is presented as a continuously growing, painless mass at late childhood. Maxilla and mandible are mostly involved in facial skeleton. Involvement of the zygomatic bone is rare. Fibrous dysplasia of the zygomatic bone may cause orbital dystopia, diplopia, proptosis, loss of visual acuity, swelling, mass formation, or facial asymmetry. We present 1 case of fibrous dysplasia with isolated zygomatic bone involvement. PMID:24220475

  10. Solitary fibrous tumor of the infratemporal fossa: A case report

    OpenAIRE

    Naresh, K. Panda; Parida Pradipta, K.; Mahesha, V.; Ashim, Das

    2007-01-01

    First described as a pleural neoplasm, the solitary fibrous tumor (fibrous mesothelioma) has been reported in a number of extrapulmonary sites, including the Head-Neck region. In the Head-Neck region, it has been described in the sinonasal tract, epiglottis, parapharyngeal, retropharyngeal spaces, parotid and infratemporal fossa. We present the second case of solitary fibrous tumor of infratemporal fossa described in world literature. A complete excision was achieved by transmaxillary approach.

  11. Fibrous metal ion adsorbent synthesized by radiation processing

    International Nuclear Information System (INIS)

    Graft polymerization is a radiation processing which can impart a desired functional group into a trunk polymer. When a nonwoven fabric is selected as the trunk polymer of the graft polymerization, a fibrous metal adsorbent can be synthesized. The resulting fibrous adsorbent realizes extremely high flow rate in the metal ion adsorption. The present paper describes the characteristic of the fibrous adsorbent and the applications to removal of toxic metals and collection of useful metals. (author)

  12. THE INFLUENCE OF SUPERPLASTICIZERS ON THE PROPERTY IS FIBROUS CONCRETE / ??????? ???????????????????? ?? ???????? ????????????

    Directory of Open Access Journals (Sweden)

    Perfilov Vladimir Aleksandrovich / ???????? ???????? ?????????????

    2015-02-01

    Full Text Available Provided are the results of experimental studies on the determination of the effect of superplasticizer additives on physical and mechanical properties of basalt fibrous concrete / ???????????? ?????????? ????????????????? ???????????? ?? ??????????? ??????? ????????????????????? ??????? ?? ??????-???????????? ???????? ????????????????????

  13. Malignant lymphoma

    International Nuclear Information System (INIS)

    This paper describes the background and treatment, especially focusing on radiotherapy (RT), of stage I-II malignant lymphoma (ML) occurring in head and neck. For diffuse large B-cell lymphoma, the most frequently occurring ML in Japan (about 40% of all MLs), the current standard protocol involves 3 cycles of chemotherapy (CT) like rituximab to cyclophosphamide/doxorubicin/vincristine/predonisolone (CHOP) regimen followed by RT. Authors use the dose around 30 Gy/15 fr for CR patients after CHOP and 40-50 Gy/20-25 fr for PR ones. Recurrence scarcely occurs in the RT target region. However, significance of RT is still somehow controversial in this ML and addition of CHOP is currently noted. Mucosa-associated lymphoid tissue lymphoma (8.45% of Japanese ML) occurs mainly in glands and orbit and may be related with Chlamydia infection. RT is usually conducted to the whole organ with lesion as the clinical target with fractionated 30 Gy. Nasal NK/T cell lymphoma (2.6%), possibly associated with Epstein-Barr (EB) virus, is usually resistant to CHOP. Recommended is CT after RT with the dose of 50-54 Gy and depending on the target site, advanced RT like intensity-modified one is desirable. Hodgkin lymphoma (about 5%) occurs in lymph node and is derived from B-lymphocyte. Irradiation field involves the region of the disease node or that additionally including its neighbors and doses of about 20 Gy and 30 Gy are given in child and adult patients, respectively. For follicular andpatients, respectively. For follicular and other tissue type lymphomas, noted are novel therapies like rituximab-combined CT, immuno-RT with 90Y-ibritumomab and 131I-tositumomab. Recently, positron emission tomography (PET) is essential for treatment assessment of the clinical response of ML in the guideline. (R.T.)

  14. Fibrous composites comprising carbon nanotubes and silica

    Science.gov (United States)

    Peng, Huisheng (Shanghai, CN); Zhu, Yuntian Theodore (Cary, NC); Peterson, Dean E. (Los Alamos, NM); Jia, Quanxi (Los Alamos, NM)

    2011-10-11

    Fibrous composite comprising a plurality of carbon nanotubes; and a silica-containing moiety having one of the structures: (SiO).sub.3Si--(CH.sub.2).sub.n--NR.sub.1R.sub.2) or (SiO).sub.3Si--(CH.sub.2).sub.n--NCO; where n is from 1 to 6, and R.sub.1 and R.sub.2 are each independently H, CH.sub.3, or C.sub.2H.sub.5.

  15. [Pleural fibrous mesothelioma. Apropos of a case].

    Science.gov (United States)

    Trombati, N; Bahlaoui, A; Cherkaoui, O; Bouayad, Z

    1994-01-01

    A 27-year-old man with an uneventful history was hospitalized after fortuitous discovery of an opacity in the right lung field. The clinical examination revealed a multi-nodular euthyroidian goiter. Laboratory tests, including blood glucose, were normal. Computed tomography of the chest showed a pleural formation and associated pleural effusion. Complete surgical exeresis led to the diagnosis of benign fibrous pleural mesothelioma. Fibromas of the pleura are rare and usually discovered due to extra thoracic signs. The clinical course is long and often silent. Surgical removal is indicated and usually is complete. PMID:7724983

  16. Malignant hyperthermia

    Directory of Open Access Journals (Sweden)

    Pollock Neil

    2007-04-01

    Full Text Available Abstract Malignant hyperthermia (MH is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stresses such as vigorous exercise and heat. The incidence of MH reactions ranges from 1:5,000 to 1:50,000–100,000 anesthesias. However, the prevalence of the genetic abnormalities may be as great as one in 3,000 individuals. MH affects humans, certain pig breeds, dogs, horses, and probably other animals. The classic signs of MH include hyperthermia to marked degree, tachycardia, tachypnea, increased carbon dioxide production, increased oxygen consumption, acidosis, muscle rigidity, and rhabdomyolysis, all related to a hypermetabolic response. The syndrome is likely to be fatal if untreated. Early recognition of the signs of MH, specifically elevation of end-expired carbon dioxide, provides the clinical diagnostic clues. In humans the syndrome is inherited in autosomal dominant pattern, while in pigs in autosomal recessive. The pathophysiologic changes of MH are due to uncontrolled rise of myoplasmic calcium, which activates biochemical processes related to muscle activation. Due to ATP depletion, the muscle membrane integrity is compromised leading to hyperkalemia and rhabdomyolysis. In most cases, the syndrome is caused by a defect in the ryanodine receptor. Over 90 mutations have been identified in the RYR-1 gene located on chromosome 19q13.1, and at least 25 are causal for MH. Diagnostic testing relies on assessing the in vitro contracture response of biopsied muscle to halothane, caffeine, and other drugs. Elucidation of the genetic changes has led to the introduction, on a limited basis so far, of genetic testing for susceptibility to MH. As the sensitivity of genetic testing increases, molecular genetics will be used for identifying those at risk with greater frequency. Dantrolene sodium is a specific antagonist of the pathophysiologic changes of MH and should be available wherever general anesthesia is administered. Thanks to the dramatic progress in understanding the clinical manifestation and pathophysiology of the syndrome, the mortality from MH has dropped from over 80% thirty years ago to less than 5%.

  17. Fibrous growth of tricalcium phosphate ceramics.

    Science.gov (United States)

    Prieto Valdés, J J; Ortiz López, J; Rueda Morales, G; Pacheco Malagon, G; Prieto Gortcheva, V

    1997-05-01

    Structural transformation and sintering processes of tricalcium phosphate (TCP) ceramics prepared from defective hydroxyapatite (Ca9HPO4(PO4)5OH) were studied by X-ray diffraction (XRD) and atomic force microscopy (AFM). Starting powders with Ca/P ratio approximately 1.5 were obtained by adding 0.5 l of 0.3 M H3PO4 solution to an equal volume of 0.45 M Ca(OH)2. In the prepared ceramics, the onset temperature for transformation of defective hydroxyapatite into TCP (witlokite) agrees with the onset temperature for sintering (800 degrees C). Sintering occurs through the formation of a fibrous structure, which resembles biological hard tissue. In the 1000-1200 degrees C range, these fibres coalesce into grains of up to 0.6 microm in size with a fibrous-laminar morphology. At the end of this sintering stage witlokite transforms into alphaTCP. At about 1450 degrees C, partial decomposition of alphaTCP into Ca2P2O7+Ca4P2O9 is observed. AFM observations suggest that Ca2P2O7 is segregated in the liquid state and increases the velocity of grain growth (up to 12 microm). PMID:15348752

  18. Imaging Findings of Fibrous Hamartoma of Infancy

    International Nuclear Information System (INIS)

    We wanted to evaluate the imaging findings of fibrous hamartoma of infancy (FHI). We retrospectively reviewed the clinical presentation and the sonographic (n = 5) and CT (n = 3) findings of 5 cases of surgically/pathologically confirmed FHI. The sonographic findings were evaluated according to the location, size, internal echogenicity and vascularity. The CT findings were evaluated according to the attenuation of the mass on both the pre- (n = 3) and postcontrast (n = 2) scans. The image findings were correlated with the pathologic findings. The mean age was 14.8 months (range, 7 months - 3 years). The location of lesions was all in the fatty layer of the back (n = 4) and upper arm (n = 1). All the lesions demonstrated-hypertrichosis on the overlying skin. The lesions measured 31.2 mm in the longest diameter (range: 18 mm - 50 mm). The sonographic findings were purely solid, heterogeneously hyperechoic and hypovacular for all the cases. The internal architecture revealed a 'layering' appearance (n = 3). The CT findings demonstrated isoattenuation, as compared to the adjacent muscle on both the pre- and postcontrast CT scans. The pathologic correlation demonstrated a characteristic 'organoid' mixture of fibrous, mucoid and fatty tissues in all cases. The diagnosis of FHI can be suggested by the sonographic findings of a superficially located, heterogeneous solid mass with a 'layering' appearance in the fatty layer of the back or arms of infants with local hypertrochosor arms of infants with local hypertrochosis on the overlying skin

  19. Imaging Findings of Fibrous Hamartoma of Infancy

    Energy Technology Data Exchange (ETDEWEB)

    Rho, Byung Hak; Lee, Hee Jung; Kwon, Sun Young [Dongsan Medical Center, Keimyung University College of Medicine, Daegu (Korea, Republic of)

    2009-09-15

    We wanted to evaluate the imaging findings of fibrous hamartoma of infancy (FHI). We retrospectively reviewed the clinical presentation and the sonographic (n = 5) and CT (n = 3) findings of 5 cases of surgically/pathologically confirmed FHI. The sonographic findings were evaluated according to the location, size, internal echogenicity and vascularity. The CT findings were evaluated according to the attenuation of the mass on both the pre- (n = 3) and postcontrast (n = 2) scans. The image findings were correlated with the pathologic findings. The mean age was 14.8 months (range, 7 months - 3 years). The location of lesions was all in the fatty layer of the back (n = 4) and upper arm (n = 1). All the lesions demonstrated-hypertrichosis on the overlying skin. The lesions measured 31.2 mm in the longest diameter (range: 18 mm - 50 mm). The sonographic findings were purely solid, heterogeneously hyperechoic and hypovacular for all the cases. The internal architecture revealed a 'layering' appearance (n = 3). The CT findings demonstrated isoattenuation, as compared to the adjacent muscle on both the pre- and postcontrast CT scans. The pathologic correlation demonstrated a characteristic 'organoid' mixture of fibrous, mucoid and fatty tissues in all cases. The diagnosis of FHI can be suggested by the sonographic findings of a superficially located, heterogeneous solid mass with a 'layering' appearance in the fatty layer of the back or arms of infants with local hypertrochosis on the overlying skin.

  20. [A case of facial fibrous dysplasia in brothers].

    Science.gov (United States)

    Hsissen, M A; Kadiri, F; Zamiati, S; Jabri, L; Rifki, S; Touhami, M; Chekkoury, I A; Benchakroun, Y

    1997-08-01

    Fibrous dysplasia is a benign bone tumor. The cranio-facial localization concern 20% of fibrous dysplasia. A congenital etiology is evoked by all the authors. Our observations ask for the real etiology of this affection: Congenital? Familial? The diagnosis is done by anatomo-pathology, and surgery is the treatment for severe cases. Relapses are frequent. PMID:9324737

  1. Fibrous monoliths: Economic ceramic matrix composites from powders [Final report

    Energy Technology Data Exchange (ETDEWEB)

    Rigali, Mark; Sutaria, Manish; Mulligan, Anthony; Creegan, Peter; Cipriani, Ron

    1999-05-26

    The project was to develop and perform pilot-scale production of fibrous monolith composites. The principal focus of the program was to develop damage-tolerant, wear-resistant tooling for petroleum drilling applications and generate a basic mechanical properties database on fibrous monolith composites.

  2. Progressive failure analysis of fibrous composite materials and structures

    Science.gov (United States)

    Bahei-El-din, Yehia A.

    1990-01-01

    A brief description is given of the modifications implemented in the PAFAC finite element program for the simulation of progressive failure in fibrous composite materials and structures. Details of the memory allocation, input data, and the new subroutines are given. Also, built-in failure criteria for homogeneous and fibrous composite materials are described.

  3. Fibrous microcapsules and methods of assembly and use thereof

    Energy Technology Data Exchange (ETDEWEB)

    Stupp, Samuel; Rozkiewicz, Dorota

    2015-01-27

    The present invention relates to assembly of peptide amphiphiles and biopolymers into fibrous microcapsules, and uses thereof. In particular, the present invention provides devices, compositions, and methods for interfacial self-assembly of peptide amphiphiles and biopolyments into fibrous microcapsules, and uses thereof.

  4. Ceramic-Fibrous-Insulation Thermal-Protection System

    Science.gov (United States)

    Leiser, Daniel; Churchward, Rex; Katvala, Victor; Stewart, David; Balter, Aliza

    1992-01-01

    New composite thermal-protection system developed in which glass-ceramic impregnated into surface of fibrous insulation. Called TUFI for toughened unipiece fibrous insulation developed as replacement for tiles with reaction-cured-glass (RCG) coating. Impregnation of glass-ceramic results in thermal protection system with insulating properties comparable to existing system but with 20 to 100 times more resistance to impact.

  5. Electrospun nanocomposite fibrous polymer electrolyte for secondary lithium battery applications

    International Nuclear Information System (INIS)

    Hybrid nanocomposite [poly(vinylidene fluoride -co- hexafluoropropylene) (PVdF-co-HFP)/magnesium aluminate (MgAl2O4)] fibrous polymer membranes were prepared by electrospinning method. The prepared pure and nanocomposite fibrous polymer electrolyte membranes were soaked into the liquid electrolyte 1M LiPF6 in EC: DEC (1:1,v/v). XRD and SEM are used to study the structural and morphological studies of nanocomposite electrospun fibrous polymer membranes. The nanocomposite fibrous polymer electrolyte membrane with 5 wt.% of MgAl2O4 exhibits high ionic conductivity of 2.80 × 10?3 S/cm at room temperature. The charge-discharge capacity of Li/LiCoO2 coin cells composed of the newly prepared nanocomposite [(16 wt.%) PVdF-co-HFP+(5 wt.%) MgAl2O4] fibrous polymer electrolyte membrane was also studied and compared with commercial Celgard separator

  6. Electrospun nanocomposite fibrous polymer electrolyte for secondary lithium battery applications

    Science.gov (United States)

    Padmaraj, O.; Rao, B. Nageswara; Jena, Paramananda; Venkateswarlu, M.; Satyanarayana, N.

    2014-04-01

    Hybrid nanocomposite [poly(vinylidene fluoride -co- hexafluoropropylene) (PVdF-co-HFP)/magnesium aluminate (MgAl2O4)] fibrous polymer membranes were prepared by electrospinning method. The prepared pure and nanocomposite fibrous polymer electrolyte membranes were soaked into the liquid electrolyte 1M LiPF6 in EC: DEC (1:1,v/v). XRD and SEM are used to study the structural and morphological studies of nanocomposite electrospun fibrous polymer membranes. The nanocomposite fibrous polymer electrolyte membrane with 5 wt.% of MgAl2O4 exhibits high ionic conductivity of 2.80 × 10-3 S/cm at room temperature. The charge-discharge capacity of Li/LiCoO2 coin cells composed of the newly prepared nanocomposite [(16 wt.%) PVdF-co-HFP+(5 wt.%) MgAl2O4] fibrous polymer electrolyte membrane was also studied and compared with commercial Celgard separator.

  7. Fibrous metaphyseal defect (fibrous cortical defect, non-ossifying fibroma). Pt. 2

    International Nuclear Information System (INIS)

    FMD, whether in the stage of a fibrous cortical defect or a non-ossifying fibroma, possesses very characteristic radiological appearances which rarely make it necessary to resort to biopsy. In order to avoid mistakes, it is necessary to observe strictly the known radiological features: metaphyseal position, clearcut relationship to the cortex, well defined margins, maximal size 6 to 7 cm., presence during growth, rarely observed in the upper extremity. The differential diagnosis, which needs to be considered only rarely, is discussed. (orig.)

  8. Method of manufacturing fibrous hemostatic bandages

    Science.gov (United States)

    Larsen, Gustavo; Spretz, Ruben; Velarde-Ortiz, Raffet

    2012-09-04

    A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.

  9. Recurrence of atypical fibroxanthoma. Diagnosis and treatment

    OpenAIRE

    Mattiola, Leandro Ricardo; Mattiola, Lyzandro; Mattiola, Giovani; Mattiola, Sandra Zucchi Moraes; Moura, Carlos Eduardo; Kirschnick, Alexandre

    2012-01-01

    Introduction: The soft tissue sarcomas (SPM) accounts for only 1% of malignant tumors of the adult population. The SPM is the most frequent malignant fibrous histiocytoma (MFH) that exhibits behavior characterized by the tendency to invasion of adjacent tissue and metastatic spread early. One of its variants is the atypical fibroxanthoma (FA). Objective: To describe a case of probable recurrence of AF underwent surgical treatment and presentation of a literature review. Case report: Patient f...

  10. Dedifferentiated chondrosarcoma with leukocytosis and elevation of serum G-CSF. A case report

    OpenAIRE

    Oda Yoshinao; Harimaya Katsumi; Matsuda Shuichi; Tanaka Kazuhiro; Yamamoto Hidetaka; Sakamoto Akio; Tsuneyoshi Masazumi; Iwamoto Yukihide

    2006-01-01

    Abstract Background G-CSF is known to function as a hematopoietic growth factor and it is known to be responsible for leukocytosis. G-CSF-producing tumors associated with leukocytosis include various types of malignancies. Case presentation We report the case of a 72-year-old man with dedifferentiated chondrosarcoma characterized by dedifferentiated components of malignant fibrous histiocytoma- or osteosarcoma-like features in addition to conventional chondrosarcoma, arising from his pelvic b...

  11. Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. I. Smooth muscle tumors.

    OpenAIRE

    Schu?rch, W.; Skalli, O.; Seemayer, T. A.; Gabbiani, G.

    1987-01-01

    A series of 3 benign and 10 malignant smooth muscle (SM) neoplasms and of 2 malignant fibrous histiocytomas was examined by light microscopy, transmission electron microscopy, two-dimensional gel electrophoresis (2D-GE) and indirect immunofluorescence, using polyclonal monospecific or monoclonal antibodies to desmin, vimentin, cytokeratin, alpha-SM and alpha-sarcomeric (alpha-SR) actins. Benign neoplasms displayed typical light-microscopic features of SM, whereas leiomyosarcomas demonstrated ...

  12. Dedifferentiated liposarcoma with leukocytosis. A case report of G-CSF-producing soft-tissue tumors, possible association with undifferentiated liposarcoma lineage

    OpenAIRE

    Matsuda Shuichi; Tanaka Kazuhiro; Yoshida Tatsuya; Matono Hiroshi; Sakamoto Akio; Oda Yoshinao; Iwamoto Yukihide

    2007-01-01

    Abstract Background Granulocyte-colony-stimulating factor (G-CSF) functions as a hematopoietic growth factor and it is responsible for leukocytosis. G-CSF-producing tumors associated with leukocytosis include various types of malignancies. Case presentation We report the case of a 72-year-old man with dedifferentiated liposarcoma characterized by dedifferentiated components of malignant fibrous histiocytoma (MFH)-like features in addition to well-differentiated lipoma-like liposarcoma, arisin...

  13. Malignant teratoma (image)

    Science.gov (United States)

    A malignant teratoma is a type of cancer consisting of cysts that contain one or more of the three ... embryonic germ layers: ectoderm, mesoderm, and endoderm. Because malignant teratomas have usually spread by the time of ...

  14. Stages of Malignant Mesothelioma

    Science.gov (United States)

    ... Advanced) Stage III (Advanced) Stage IV (Advanced) After malignant mesothelioma has been diagnosed, tests are done to ... brain cancer. The following stages are used for malignant mesothelioma: Stage I (Localized) Stage I is divided ...

  15. MRI of fibrous cortical defect and non-ossifying fibroma

    Energy Technology Data Exchange (ETDEWEB)

    Mishima, Yoshiko; Aoki, Takatoshi; Watanabe, Hideyuki; Nakata, Hajime; Hashimoto, Hiroshi; Nakamura, Toshitaka [Univ. of Occupational and Environmental Health, Kitakyushu, Fukuoka (Japan). School of Medicine

    1999-02-01

    Fibrous cortical defect and non-ossifying fibroma are the benign fibrous lesions of bone commonly involving children. Their diagnosis is usually done with radiography, and MR examinations are rarely performed. We evaluated MRI findings of 11 lesions in 10 cases of fibrous cortical defect and non-ossifying fibroma. Signal intensity of the lesions was varied and large lesions (2 cm<) tended to show heterogeneous signal intensity on both T1-weighted and T2-weighted images corresponding to a mixture of components including fibrous tissue, hemosiderin and foam cells. MRI helps to delineate the extent of the involved bone and to assess the various histological components of the lesions. However, their diagnosis is basically made on the radiographic findings and the role of MRI is limited. (author)

  16. MRI of fibrous cortical defect and non-ossifying fibroma

    International Nuclear Information System (INIS)

    Fibrous cortical defect and non-ossifying fibroma are the benign fibrous lesions of bone commonly involving children. Their diagnosis is usually done with radiography, and MR examinations are rarely performed. We evaluated MRI findings of 11 lesions in 10 cases of fibrous cortical defect and non-ossifying fibroma. Signal intensity of the lesions was varied and large lesions (2 cm<) tended to show heterogeneous signal intensity on both T1-weighted and T2-weighted images corresponding to a mixture of components including fibrous tissue, hemosiderin and foam cells. MRI helps to delineate the extent of the involved bone and to assess the various histological components of the lesions. However, their diagnosis is basically made on the radiographic findings and the role of MRI is limited. (author)

  17. Rare case of an abdominal mass: Reactive nodular fibrous pseudotumor of the stomach encroaching on multiple abdominal organs.

    Science.gov (United States)

    Yi, Xiao-Jiang; Chen, Chuang-Qi; Li, Yin; Ma, Jin-Ping; Li, Zhi-Xun; Cai, Shi-Rong; He, Yu-Long

    2014-04-16

    Reactive nodular fibrous pseudotumor (RNFP), which presents abdominal clinical manifestations and malignant radiographic results, usually requires radical resection as the treatment. However, RNFP has been recently described as an extremely rare benign post-inflammatory lesion of a reactive nature, which typically arises from the sub-serosal layer of the digestive tract or within the surrounding mesentery in association with local injury or inflammation. In addition, a postoperative diagnosis is necessary to differentiate it from the other reactive processes of the abdomen. Furthermore, RNFP shows a good prognosis without signs of recurrence or metastasis. A 16-year-old girl presented with a 3-mo history of epigastric discomfort, and auxiliary examinations suggested a malignant tumor originating from the stomach; postoperative pathology confirmed RNFP, and after a 2-year follow-up period, the patient did not display any signs of recurrence. This case highlights the importance of preoperative pathology for surgeons who may encounter similar cases. PMID:24749124

  18. Chondrosarcoma occurring in a patient with polyostotic fibrous dysplasia

    International Nuclear Information System (INIS)

    A 36-year-old white man with polyostotic fibrous dysplasia was found to have a high-grade chondrosarcoma arising from the left ilium. Although a left hemipelvectomy was performed, the patient subsequently developed sacral and pulmonary metastases and succumbed to his disease. This patient represents the first documented example of an unequivocally high-grade chondrosarcoma arising in an area of fibrous dysplasia without prior irradiation. (orig.)

  19. Impregnated Fibrous Materials. Report of a Study Group on Impregnated Fibrous Materials

    International Nuclear Information System (INIS)

    There has recently been renewed interest in the use of radiation from radioisotopes or particle accelerators to initiate and sustain chemical reactions. Particular attention is being paid to the production of wood-plastic composites, a process which is now a commercial reality with radiation competing against chemical methods to enhance the properties of wood. It has been reported that water repellancy, hardness, weathering, insect and chemical resistance, compressive, bending and shear strength can be significantly improved by the process, but so far there has been a limited commercial outlet for the product. Papers on this subject were presented at the International Atomic Energy Agency's Symposium on Industrial Uses of Large Radiation Sources, Salzburg, May 1963, and since then the Agency has been aware of the interest of developing countries in conducting research on wood and other fibrous materials as a means of further exploiting natural resources. It was felt that some attempt should be made to co-ordinate, on a regional basis, the work being done in this field and at the same time review the world status, including the associated technology in such areas as monomer-polymer chemistry and impregnation techniques where they are directly related to this work. Because of the wide range of fibrous materials being studied there, Asia and the Far East was chosen as the most representative area and 39 participants from 13 countries, and from international organizations, met in Bangkok from 20 to 24 November 1967 to assess the potential of impregnated fibrous materials. This report is a record of the meeting and is based not only on work performed both inside and outside the region but also on details of the resources and industries in the area

  20. Simulation and Analysis of Unbonded Nonwoven Fibrous Structures

    Directory of Open Access Journals (Sweden)

    Behnam Pourdeyhimi

    2006-11-01

    Full Text Available In this work we report on our algorithm for generating 3-D virtual structures resembling un-bonded fibrous webs. The paper discusses short and infinitely long fibers, each emulating a category of nonwoven fibrous medium. The structure Solid Volume Fraction (SVF, being the most important characteristic of a fibrous porous medium, is calculated for different fiberwebs and discussed in details. It is shown that the SVF of the fibrous structures generated by our algorithm is independent of the basis weight. In other words, the porosity of the medium is only a function of the fiber properties – this is as expected. It is also demonstrated that by decreasing the fiber diameter while keeping other properties of the virtual fiberweb constant causes the SVF to decrease almost linearly. The same is not observed for the fiber rigidity. The capability of our algorithm for generating fibrous webs made up of layers of different fibers is demonstrated and their properties are discussed. The application of such virtual fibrous structures in modeling transport phenomena in nonwoven materials and their potential applications in load-deformation studies are discussed.

  1. Treating Fibrous Insulation to Reduce Thermal Conductivity

    Science.gov (United States)

    Zinn, Alfred; Tarkanian, Ryan

    2009-01-01

    A chemical treatment reduces the convective and radiative contributions to the effective thermal conductivity of porous fibrous thermal-insulation tile. The net effect of the treatment is to coat the surfaces of fibers with a mixture of transition-metal oxides (TMOs) without filling the pores. The TMO coats reduce the cross-sectional areas available for convection while absorbing and scattering thermal radiation in the pores, thereby rendering the tile largely opaque to thermal radiation. The treatment involves a sol-gel process: A solution containing a mixture of transition-metal-oxide-precursor salts plus a gelling agent (e.g., tetraethylorthosilicate) is partially cured, then, before it visibly gels, is used to impregnate the tile. The solution in the tile is gelled, then dried, and then the tile is fired to convert the precursor salts to the desired mixed TMO phases. The amounts of the various TMOs ultimately incorporated into the tile can be tailored via the concentrations of salts in the solution, and the impregnation depth can be tailored via the viscosity of the solution and/or the volume of the solution relative to that of the tile. The amounts of the TMOs determine the absorption and scattering spectra.

  2. Fibrous tumor located in pleura (pleural fibroma)

    International Nuclear Information System (INIS)

    The results of imaging studies are presented in 7 cases of fibrous tumor located in pleura (pleural fibroma) dealt with in our center over the past 9 years. The series consisted of 4 women and 3 men, ranging in age between 32 and 65 years (mean: 46 years). In 5 cases, the tumors was found by chance. The symptoms observed in the other 2 included cough, dyspnea and pleuritic pain. The imaging methods employed were conventional radiology, conventional tomography (n=2), ultrasonography (n=3), computed tomography (n=6) and magnetic resonance (n=1). The tumors presented as mediastinal masses (n=5), intra parenchymal masses (n=1) and, in only 1 case, as the typical extra parenchymal mass. The results of the imaging studies did not provide the precise preoperative diagnosis. All but one of the patients underwent surgery and, in five cases, the tumor was resectable, with satisfactory outcome and no subsequent signs of recurrence. The only patient with a non resectable tumor died of respiratory failure shortly after surgery. (Author)

  3. Intracranial solitary fibrous tumor: Imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Clarencon, Frederic, E-mail: fredclare5@msn.com [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Bonneville, Fabrice [Department of Neuroradiology, Hopital Rangueil, Toulouse University Hospital, 31000 Toulouse (France); Rousseau, Audrey [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Galanaud, Damien [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Kujas, Michele [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Naggara, Olivier [Department of Neuroradiology, St Anne Hospital, 75014 Paris (France); Cornu, Philippe [Department of Neurosurgery, Pitie-Salpetriere Hospital (France); Chiras, Jacques [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France)

    2011-11-15

    Objective: To study the neuroimaging features of intracranial solitary fibrous tumors (ISFTs). Materials and methods: Retrospective study of neuroimaging features of 9 consecutive histopathologically proven ISFT cases. Location, size, shape, density, signal intensity and gadolinium uptake were studied at CT and MRI. Data collected from diffusion-weighted imaging (DWI) (3 patients), perfusion imaging and MR spectroscopy (2 patients), and DSA (4 patients) were also analyzed. Results: The tumors most frequently arose from the intracranial meninges (7/9), while the other lesions were intraventricular. Tumor size ranged from 2.5 to 10 cm (mean = 6.6 cm). They presented multilobular shape in 6/9 patients. Most ISFTs were heterogeneous (7/9) with areas of low T2 signal intensity that strongly enhanced after gadolinium administration (6/8). Erosion of the skull was present in about half of the cases (4/9). Components with decreased apparent diffusion coefficient were seen in 2/3 ISFTs on DWI. Spectroscopy revealed elevated peaks of choline and myo-inositol. MR perfusion showed features of hyperperfusion. Conclusion: ISFT should be considered in cases of extra-axial, supratentorial, heterogeneous, hypervascular tumor. Areas of low T2 signal intensity that strongly enhance after gadolinium injection are suggestive of this diagnosis. Restricted diffusion and elevated peak of myo-inositol may be additional valuable features.

  4. Intracranial solitary fibrous tumor: Imaging findings

    International Nuclear Information System (INIS)

    Objective: To study the neuroimaging features of intracranial solitary fibrous tumors (ISFTs). Materials and methods: Retrospective study of neuroimaging features of 9 consecutive histopathologically proven ISFT cases. Location, size, shape, density, signal intensity and gadolinium uptake were studied at CT and MRI. Data collected from diffusion-weighted imaging (DWI) (3 patients), perfusion imaging and MR spectroscopy (2 patients), and DSA (4 patients) were also analyzed. Results: The tumors most frequently arose from the intracranial meninges (7/9), while the other lesions were intraventricular. Tumor size ranged from 2.5 to 10 cm (mean = 6.6 cm). They presented multilobular shape in 6/9 patients. Most ISFTs were heterogeneous (7/9) with areas of low T2 signal intensity that strongly enhanced after gadolinium administration (6/8). Erosion of the skull was present in about half of the cases (4/9). Components with decreased apparent diffusion coefficient were seen in 2/3 ISFTs on DWI. Spectroscopy revealed elevated peaks of choline and myo-inositol. MR perfusion showed features of hyperperfusion. Conclusion: ISFT should be considered in cases of extra-axial, supratentorial, heterogeneous, hypervascular tumor. Areas of low T2 signal intensity that strongly enhance after gadolinium injection are suggestive of this diagnosis. Restricted diffusion and elevated peak of myo-inositol may be additional valuable features.

  5. A call to expand regulation to all carcinogenic fibrous minerals

    Science.gov (United States)

    Baumann, F.; Steele, I.; Ambrosi, J.; Carbone, M.

    2013-05-01

    The regulatory term "asbestos" groups only the six fibrous minerals that were commercially used among approximately 400. The carcinogenicity of these six regulated minerals has been largely demonstrated and is related to fiber structure, fiber length/diameter ratio, and bio-persistence. From a public perception, the generic term "asbestos" refers to the fibrous minerals that cause asbestosis, mesothelioma and other cancers. However, other non-regulated fibrous minerals are potentially as dangerous as the regulatory asbestos because they share similar physical and chemical properties, epidemiological studies have demonstrated their relationship with asbestos-related diseases, and both in vitro and in vivo experiments have established the toxicity of these minerals. For example, the non-regulated asbestiform winchite and richterite minerals that contaminated the vermiculite mined from Libby, Montana, (USA) were associated with mesothelioma, lung cancer and asbestosis observed among the area's residents and miners. Many other examples of non-regulated carcinogenic fibrous minerals include, but are not limited to, antigorite, arfvedsonite, balangeroite, carlosturanite, erionite, fluoro-edenite, hornblende, mordenite, palygorskite, and sepiolite. To propose a regulatory definition that would provide protection from all carcinogenic fibers, we have conducted an interdisciplinary literature review to compare the characteristics of "asbestos" and of non-regulated mineral fibers that relate to carcinogenicity. We specifically studied two non-regulated fibrous minerals that are associated with asbestos-related diseases: the serpentine antigorite and the zeolite erionite. Both examples underscore the problem of regulation based on commercial, rather than scientific principles: 1) the occurrence of fibrous antigorite in materials used to pave roads has been correlated with high mesothelioma rates in New Caledonia. Antigorite was also the cause of asbestosis in Poland, and in vitro and in vivo studies have shown its toxic and carcinogenic properties; 2) the carcinogenic properties of erionite have been demonstrated, and erionite has been associated with a mesothelioma epidemic in Anatolia, Turkey. Erionite is also widespread in areas of north central USA, where it is contained in gravel paving stone, and is cause for concern due to increased commercial traffic. Numerous studies have shown that non-regulated fibrous materials pose similar health hazards to regulated "asbestos". An increase in human activities in areas where these fibrous minerals are present, such as in surficial rock and soil, will result in the generation of airborne dust, exposing people to carcinogenic fibers. The current limited regulation leads people to believe that only the six mineral fibers referred to as "asbestos" are dangerous. We propose that fibrous minerals should be regulated as a single group, as they have similar deleterious effects on the human body. Regulations would be simplified and more effective if they embrace all carcinogenic fibrous minerals.

  6. Pediatric malignancies presenting as a possible infectious disease

    Directory of Open Access Journals (Sweden)

    Robinson Joan L

    2007-05-01

    Full Text Available Abstract Background The clinical, laboratory, and radiological features of malignancy can overlap with those of infection. The purpose of this study was to determine the findings in children who were initially thought to have an infectious disease but ultimately proved to have a malignancy. Methods The database of patients diagnosed with a malignancy in the Northern Alberta Children's Cancer Program (NACCP January 1, 1993 to December 31, 2003 was merged with the database of inpatients referred to the infectious diseases service at the Stollery Children's Hospital and charts were reviewed on all patients referred to the infectious diseases consult service prior to the diagnosis of malignancy. Results An infectious diseases consultation for diagnosis was requested in 21 of 561 patients prior to the confirmation of malignancy, and 3 of these 21 patients had both infection and malignancy (leukemia (N = 13, lymphoma (N = 3, rhabdomyosarcoma (N = 1, Langerhan's cell histiocytosis (N = 1, fibrous histicocytosis (N = 1, ependymoma (N = 1, and neuroblastoma (N = 1. The most common reason for infectious diseases consultation was suspected muskuloskeletal infection (N = 9. A palpable or radiographically enlarged spleen was noted in 11 patients (52%. All but 2 patients had abnormal hematologic parameters while an elevated lactate dehydrogenase (LDH occurred in 10 patients (48%. Delay of diagnosis because of investigation or therapy for an infectious disease occurred in only 2 patients. Conclusion It is not common for treatment of pediatric malignancies to be delayed because infection is thought to be the primary diagnosis. However, pediatric infectious diseases physicians should consider malignancy in the differential diagnosis when they see patients with fever and bone pain, unexplained splenomegaly or abnormal complete blood cell counts. Other clues may include hepatomegaly or elevated LDH.

  7. Ultrasonographic features of fibrous hamartoma of infancy

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seungsoo; Kim, Myung-Joon; Lee, Mi-Jung [Yonsei University College of Medicine, Department of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Seoul (Korea, Republic of); Choi, Young-Hun; Cheon, Jung-Eun [Seoul National University Children' s Hospital, Department of Radiology, Seoul (Korea, Republic of); Koh, Myoung Ju [Yonsei University College of Medicine, Department of Pathology, Seoul (Korea, Republic of)

    2014-05-15

    To review imaging features of fibrous hamartoma of infancy (FHI), focusing on ultrasonography (US) findings. We retrospectively reviewed pediatric patients who were diagnosed with pathologically confirmed FHI in two children's hospitals from 2004 to 2013. Imaging features of US, Doppler US, and magnetic resonance imaging (MRI) were evaluated. Thirteen pediatric patients (M:F = 7:6; age 5-22 months, mean 11.3 months) were included. Mean lesion size was 3.2 cm (range, 0.7-8.0 cm). The tumors were located in the back (n = 4), scrotum (n = 2), scalp, shoulder, axilla, forearm, intergluteal cleft, inguinal area, and thigh. US was performed in 11 patients. With the exception of two scrotal masses, all masses were located in the dermal and subcutaneous layer. All masses demonstrated heterogeneous hyperechogenicity with a ''serpentine pattern'' of intervening hypoechoic portions in the hyperechoic mass. The margins were ill-defined (n = 9) or lobulated (n = 2). Doppler US was performed in nine patients and showed no (n = 6) or minimal (n = 3) vascularity. MRI was performed in five patients and the masses showed heterogeneous signal intensity with the presence of fat on T1- and T2-weighted images. FHI is a tumor that is typically located in the dermal and subcutaneous layer in young children less than 2 years old and presents as a heterogeneously hyperechoic mass with a ''serpentine pattern'' and ill-defined or lobulated margin on US and no remarkable vascularity on Doppler US. (orig.)

  8. Diffuse reflectance spectroscopy of fibrous proteins.

    Science.gov (United States)

    Millington, Keith R

    2012-09-01

    UV-visible diffuse reflectance (DR) spectra of the fibrous proteins wool and feather keratin, silk fibroin and bovine skin collagen are presented. Natural wool contains much higher levels of visible chromophores across the whole visible range (700-400 nm) than the other proteins and only those above 450 nm are effectively removed by bleaching. Both oxidative and reductive bleaching are inefficient for removing yellow chromophores (450-400 nm absorbers) from wool. The DR spectra of the four UV-absorbing amino acids tryptophan, tyrosine, cystine and phenylalanine were recorded as finely ground powders. In contrast to their UV-visible spectra in aqueous solution where tryptophan and tyrosine are the major UV absorbing species, surprisingly the disulphide chromophore of solid cystine has the strongest UV absorbance measured using the DR remission function F(R)(?). The DR spectra of unpigmented feather and wool keratin appear to be dominated by cystine absorption near 290 nm, whereas silk fibroin appears similar to tyrosine. Because cystine has a flat reflectance spectrum in the visible region from 700 to 400 nm and the powder therefore appears white, cystine absorption does not contribute to the cream colour of wool despite the high concentration of cystine residues near the cuticle surface. The disulphide absorption of solid L: -cystine in the DR spectrum at 290 nm is significantly red shifted by ~40 nm relative to its wavelength in solution, whereas homocystine and lipoic acid showed smaller red shifts of 20 nm. The large red shift observed for cystine and the large difference in intensity of absorption in its UV-visible and DR spectra may be due to differences in the dihedral angle between the crystalline solid and the solvated molecules in solution. PMID:22218994

  9. Differences in lectin binding of malignant pleural mesothelioma and adenocarcinoma of the lung.

    OpenAIRE

    Kawai, T.; Greenberg, S. D.; Truong, L. D.; Mattioli, C. A.; Klima, M.; Titus, J. L.

    1988-01-01

    In order to differentiate between malignant pleural mesothelioma and adenocarcinoma of the lung, the glycoconjugate profiles of 6 reactive mesothelial lesions, 23 mesotheliomas (17 epithelial, 1 desmoplastic, 2 biphasic, and 3 fibrous types), and 28 well-differentiated pulmonary adenocarcinomas were evaluated with the use of 8 lectins in addition to anti-carcinoembryonic, anti-keratin and anti-epithelial membrane antigen. Formalin-fixed, paraffin-embedded tissues were stained with the avidin-...

  10. Mesotheliomas induced in rats by the fibrous mineral erionite are independent from p53 alterations.

    Science.gov (United States)

    Kleymenova, E V; Horesovsky, G; Pylev, L N; Everitt, J

    1999-12-01

    The development of human malignant mesothelioma (MM) is strongly associated with occupational or environmental exposure to certain natural mineral fibers, although the genetic mechanisms underlying this malignancy remain unclear. Although the p53 gene is frequently mutated in various tumors, human asbestos-associated MMs appear to develop independently from p53 alterations. The high mesotheliomagenic potency of natural fibrous mineral erionite is well established in humans and rodents, but no data regarding genetic alterations in erionite-associated tumors are currently available. Previous speculations that the oncogenic mechanisms underlying asbestos and erionite carcinogenesis may differ led us to examine whether the p53 gene is targeted in erionite carcinogenesis. Fifteen erionite-induced rat MMs as well as six cell lines derived from asbestos-induced and spontaneous rat MM were analyzed for p53 mutations by direct DNA sequencing and immunohistochemical analysis. Both approaches did not reveal p53 alterations in rat MM samples used in the study indicating that, similar to asbestos carcinogenesis, erionite carcinogenesis does not target the p53 tumor suppressor gene. PMID:10660089

  11. Electrospun nanocomposite fibrous polymer electrolyte for secondary lithium battery applications

    Energy Technology Data Exchange (ETDEWEB)

    Padmaraj, O.; Rao, B. Nageswara; Jena, Paramananda; Satyanarayana, N., E-mail: nallanis2011@gmail.com [Department of Physics, Pondicherry University, Pondicherry-605014 (India); Venkateswarlu, M. [R and D, Amaraja batteries, Thirupathi-517501 (India)

    2014-04-24

    Hybrid nanocomposite [poly(vinylidene fluoride -co- hexafluoropropylene) (PVdF-co-HFP)/magnesium aluminate (MgAl{sub 2}O{sub 4})] fibrous polymer membranes were prepared by electrospinning method. The prepared pure and nanocomposite fibrous polymer electrolyte membranes were soaked into the liquid electrolyte 1M LiPF{sub 6} in EC: DEC (1:1,v/v). XRD and SEM are used to study the structural and morphological studies of nanocomposite electrospun fibrous polymer membranes. The nanocomposite fibrous polymer electrolyte membrane with 5 wt.% of MgAl{sub 2}O{sub 4} exhibits high ionic conductivity of 2.80 × 10{sup ?3} S/cm at room temperature. The charge-discharge capacity of Li/LiCoO{sub 2} coin cells composed of the newly prepared nanocomposite [(16 wt.%) PVdF-co-HFP+(5 wt.%) MgAl{sub 2}O{sub 4}] fibrous polymer electrolyte membrane was also studied and compared with commercial Celgard separator.

  12. Recurring fibrous dysplasia of anthro maxillary with cranial base invasion

    Directory of Open Access Journals (Sweden)

    Sousa, Kátia Maria Marabuco de

    2009-09-01

    Full Text Available Introduction: Fibrous dysplasia is an osseous lesion with an unknown etiology. It is characterized by the osseous maturation insufficiency. It may affect any bone, but the affection of craniofacial bones is the most critical for otorhinolaryngology. Maxilla is the most affected facial bone and the orbitary invasion is an uncommon event. The symptoms are unspecific and for its low suspicion and uncommonness, the diagnosis is generally late. The monostotic form presents a slow growth and asymptomatic course and needs to be followed up. The polyostotic type has a progressive behavior and is associated to recurrence and complications. Objective: To present two cases of patients with fibrous dysplasia diagnosis and describe the clinical presentation, radiological findings and the treatment of this pathology. Cases Report: Two cases of fibrous dysplasia are reported, which initially presented unspecific symptomatology, but with characteristic radiologic signs. They were submitted to surgical treatment for resection of the lesions and evolved with frequent recurrences with extensive affection of the facial sinuses, one patient had cranial base invasion and frontal craniotomy was needed for tumoral excision. Final Comments: Fibrous dysplasia is an uncommon osteopathy. The tomography is the choice method for characterization of the tumoral expansion, and helps in the surgical planning. The surgical strategy is indicated for symptomatic lesions, functions alterations or anatomic disorders. This article describes two uncommon manifestations of recurrent fibrous dysplasia with an extensive affection of anthro maxillary, ethmoidal and sphenoid sinuses, in addition to orbitary and cranial base invasion.

  13. Malignant blue nevus

    OpenAIRE

    Sgs, Krishnan; Yesudian Devakar; Jayaraman M; Janaki V; Yesudian Patrick

    1997-01-01

    Blue nevus represents an aberrant collection of functioning benign dermal melanocytes. Its malignant degeneration is rare and is regarded as a form of malignant melanoma. We report a case of 35-year old male with this rare condition whose primary lesion over left foot ulcerated and patient later succumbed to multiple metastases.

  14. Unusual Malignant Breast Lesions

    Directory of Open Access Journals (Sweden)

    D. Farrokh

    2007-05-01

    Full Text Available Numerous unusual benign and malignant breast le-sions may be seen occasionally or rarely. Some of these lesions are distinctive and easily recognized be-cause of diagnostic clinical or radiographic criteria such as inflammatory carcinoma or Paget's disease, which are primarily a clinical diagnosis. Most of the unusual malignant breast lesions have no specific di-agnostic signs and may show the mammographic or ultrasonic findings of benign lesions. Although most radiologists may never see many of the unusual ma-lignant breast tumors, but it is important to be aware of these malignant lesions. In this article, we will present our 10-years experi-ence about unusual malignant breast lesions that in-clude breast sarcoma, phylloides tumor, Inflamma-tory carcinoma, intracystic carcinoma, Paget's dis-ease, primary lymphoma of the breast, breast metas-tasis and breast carcinoma in women less than 25 years old.

  15. Primary ovarian malignant melanoma

    Directory of Open Access Journals (Sweden)

    Kostov Miloš

    2010-01-01

    Full Text Available Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

  16. Polyostotic Fibrous Dysplasia of Cranio-Maxillofacial Area

    International Nuclear Information System (INIS)

    Fibrous dysplasia is believed to be a hamartomatous developmental lesion of unknown origin. This disease is divided into monostotic and polyostotic fibrous dysplasia. Polyostotic type can be divided into craniofacial type, Lichtenstein-Jaffe type, and McCune-Albright syndrome. In this case, a 31-year-old female presented spontaneous loss of right mandibular teeth before 5 years and has shown continuous expansion of right mandibular alveolus. Through the radiographic view, the coarse pattern of the mixed radiopaque-lucent lesion was seen on the right mandibular body, and there was diffuse pattern of the mixed radiopaque-lucent lesion with ill-defined margin in the left mandibular body. In the right calvarium, the lesion had cotton-wool appearance. Partial excision for contouring, multiple extraction, and alveoloplasty were accomplished under general anesthesia for supportive treatment. Finally we could conclude this case was polyostotic fibrous dysplasia of cranio-maxillofacial area based on the clinical, radiologic finding, and histopathologic examination.

  17. Magnetoelectric effects in multiferroic fibrous composite with imperfect interface

    International Nuclear Information System (INIS)

    This paper investigates the magnetoelectroelastic responses of multiferroic fibrous composites with imperfectly bonded interface under longitudinal shear. The proposed imperfect interface model is a natural generalization of the shear lag (or the spring layer) model. By virtue of the complex variable method, we first consider the case where an isolated circular multiferroic fiber is imperfectly bonded to an infinite multiferroic matrix. Very concise expressions for the complex field potentials characterizing the magnetoelectroelastic fields inside and outside the circular fiber are obtained when the matrix is subjected to the remote uniform magnetoelectroelastic loading. The Mori-Tanaka mean-field method is then employed to derive the effective moduli of the multiferroic fibrous composite made of randomly distributed fibers reinforced to the matrix. Particularly we demonstrate that the interfacial imperfection in elasticity, electricity, and magnetism will always cause a significant reduction in the magnetoelectric coefficient of the BaTiO3-CoFe2O4 fibrous composite

  18. Natural, forced and mixed convection in fibrous insulation

    International Nuclear Information System (INIS)

    A numerical solution of flow and temperature distribution in fibrous insulation has been obtained. Rectangular and cylindrical geometries have been modeled. Boundary conditions included permeable hot wall and convective heat transfer at the walls. Good agreement has been obtained with published experimental and numerical values on rectangular cavities. The computed velocity and temperature profiles gave a better understanding of flow and heat transfer phenomena in fibrous insulation. Local cold wall and average Nusselt numbers presented, provide useful information in the design of the fibrous insulation for concrete reactor vessel and primary coolant piping of the gas cooled nuclear power plants. Average Nusselt number has been correlated with Rayleigh number when only natural convection is present, and with Rayleigh and Reynolds numbers when a combination of natural and forced convection is present

  19. Genetics Home Reference: Malignant hyperthermia

    Science.gov (United States)

    ... Recent literature OMIM Genetic disorder catalog Conditions > Malignant hyperthermia On this page: Description Genetic changes Inheritance Diagnosis ... Glossary definitions Reviewed October 2007 What is malignant hyperthermia? Malignant hyperthermia is a severe reaction to particular ...

  20. Dust loading characteristics of high inertial fibrous filters.

    Science.gov (United States)

    Stenhouse, J I; Bloom, G P; Chard, N T

    1978-03-01

    The dust retention efficiency of a model fibrous filter operated in the high inertia regime has been measured over the size range 2-22 micrometer. The results of a program to measure the influence of loading on grade efficiency are reported. It is shown that the efficiency of particle retention increases with loading initially, then falls off as the filter becomes loaded to its maximum capacity. The effect of test dust feed size distribution has also been investigated. Under some circumstances this parameter may have a critical effect on the overall efficiency. The mechanisms responsible for the observed behavior are described and their implications in fibrous filtration discussed. PMID:645548

  1. Fibrous dysplasia of the jaws associated with secondary hyperparathyroidism: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Whi, Jung Hyun; Kim, Young Joo; Chun, Kyung Ah; Kim, Ki Tae; Chang, Eun Deok; Kim, Young Ok; Lee, Won [The Catholic University of Korea, Uijongbu (Korea, Republic of)

    2007-06-15

    There have been few reports on fibrous dyplasia associated with secondary hyperparathyroidism. We report a case of a hemodialysis patient with secondary hyperparathyroidism concomitant with fibrous dysplasia of the jaws causing an abnormal deformity.

  2. Fibrous dysplasia of the jaws associated with secondary hyperparathyroidism: a case report

    International Nuclear Information System (INIS)

    There have been few reports on fibrous dyplasia associated with secondary hyperparathyroidism. We report a case of a hemodialysis patient with secondary hyperparathyroidism concomitant with fibrous dysplasia of the jaws causing an abnormal deformity

  3. Malignant pericardial effusion.

    Science.gov (United States)

    Burazor, I; Imazio, M; Markel, G; Adler, Y

    2013-01-01

    Malignant pericardial effusion is a common and serious manifestation in malignancies. The origins of the malignant process include solid tumors or hematological malignancies, while primary neoplasms of the pericardium are less common. In the oncological patient, pericardial effusion may develop by several different mechanisms, namely by direct or metastatic spread of the primary process or as a complication of antineoplastic therapies. In some cases, pericardial effusion may be the first manifestation of the disease, and that is why malignancy must be excluded in every case of an acute pericardial disease with cardiac tamponade at presentation, rapidly increasing pericardial effusion and an incessant or recurrent course. Thus, the definite differentiation of malignant pericardial effusion and rapid diagnosis are of particular therapeutic and prognostic importance. Management of these patients is multidisciplinary and requires team work, but at present there is a need for further research. An individual treatment plan should be established, taking into account cancer stage, the patient's prognosis, local availability and experience. In emergency cases with cardiac tamponade or significant effusion, initial relief can be obtained with pericardiocentesis. Despite the magnitude of this serious problem, little progress has been made in the treatment of pericardial effusion secondary to malignant disease. PMID:23571453

  4. Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma

    Science.gov (United States)

    2014-09-08

    Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Childhood Alveolar Soft-part Sarcoma; Childhood Angiosarcoma; Childhood Epithelioid Sarcoma; Childhood Fibrosarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Mesenchymoma; Childhood Neurofibrosarcoma; Childhood Synovial Sarcoma; Dermatofibrosarcoma Protuberans; Metastatic Childhood Soft Tissue Sarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Stage I Adult Soft Tissue Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

  5. Radiotherapy of malignant granuloma

    International Nuclear Information System (INIS)

    The paper presents development and role of radiotherapy in the treatment of patients with malignant granuloma. Scheme of therapy depending on the degree of clinical and histological advancement and presence or lack of general symptoms is proposed. (author)

  6. Infection and Malignancy

    Science.gov (United States)

    ... Avoid going barefoot Use insect repellent especially at dawn and dusk Clean cuts and scrapes with soap ... malignancies, but taking anti-rejection drugs for a long time is the basis for the higher rate ...

  7. Brain Malignancies Steering Committee

    Science.gov (United States)

    The Brain Malignancy Steering Committee evaluates and prioritizes concepts for phase 3 and large phase 2 therapeutic clinical trials to be conducted in the NCI National Clinical Trials Network (NCTN).

  8. Low-grade myxofibrosarcoma following a metal implantation in femur: a case report

    OpenAIRE

    Li, Weisong; Li, Dan; Zhu, Xiansen; Lu, Shaohui; He, Chunlei; Yang, Qingchun

    2014-01-01

    Myxofibrosarcoma is a myxoid variant of malignant fibrous histiocytoma that most commonly involves the extremities of elderly people. However, a primary myxofibrosarcoma with bone invasion in young adults is extremely rare. Herein, we report the case of a 31-year-old male with a gradually enlarging left thigh mass, who had a history of left femur fracture and received an open reduction and internal fixation with titanium alloy plates and screws 33 months previously. Imaging investigations rev...

  9. Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiation-induced high-grade breast sarcoma

    OpenAIRE

    Quadros, Claudio Almeida; Vasconcelos, Alessandro; Andrade, Roque; Ramos, Roge?rio Santos; Studart, Eduardo; Nascimento, Geraldo; Trajano, Andre?

    2006-01-01

    This article is a case report of a high grade, radio-induced, breast malignant fibrous histiocytoma (undifferentiated high grade pleomorphic sarcoma), which developed in a 44-year old female, seven years after breast conservative surgery and radiotherapy for a T1N0M0 invasive left breast ductal carcinoma. The sarcoma presented as a fast growing tumour, 9.5 cm in the largest diameter, with skin, left breast, chest wall muscle and rib invasion.

  10. Diffuse Increased FDG Uptake in the Bone Marrow due to Leukemoid Reaction

    OpenAIRE

    Celal Tekinba?; Karyag?ar, Sevda S.; Sava? Karya?ar; Muharrem Erol; Esat Yamaç

    2012-01-01

    PET-CT scan showed diffuse increased FDG uptake in the bone marrow in patient with  pulmonary malignant fibrous histiocytoma who was referred to our clinic for preoperative staging. Recent chemotheraphy treatment, granulocyte colony-stimulating factor using was not there on patients medical history. Total leukocyte count was 51800/?L, with 92.1 % neutrophils, 0.7 % eosinophils, 4.3 %  lymphocytes, and 2.8 % monocytes. Bone marrow biopsy was revealed a hypercellular ma...

  11. Enhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin

    OpenAIRE

    Dietze, A.; Peng, Q.; Selbo, P. K.; Kaalhus, O.; Mu?ller, C.; Bown, S.; Berg, K.

    2005-01-01

    Photochemical internalisation (PCI) is a technique for releasing biologically active macromolecules from endocytic vesicles by light activation of a photosensitiser localised in the same vesicles of targeted cells. This study investigated the PCI of the toxin gelonin as a way of enhancing the effect of photodynamic therapy (PDT) on a human malignant fibrous histiocytoma transplanted into nude mice using the photosensitiser disulphonated aluminium phthalocyanine (AlPcS2a). Pharmacokinetic stud...

  12. A case of dedifferentiated liposarcoma showing a biphasic pattern on 2-deoxy-2-F18- fluoro-D-glucose positron emission tomography/ computed tomography

    OpenAIRE

    Kenichi Wakasa; Hiroaki Nakamura; Jun Takada; Naoto Oebisu; Manabu Hoshi

    2013-01-01

    Integrated 2-deoxy-2-F18-fluoro-D-glucose positron emission tomography combined with computed tomography (FDG-PET/CT) has been used in the field of soft tissue sarcoma. We report an 81-year-old man with dedifferentiated liposarcoma in the left thigh, which was composed of well-differentiated liposarcoma and pleomorphic malignant fibrous histiocytoma. As well as other radiological modalities, FDG-PET was able to demonstrate a biphasic signal pattern composed of well-differentiated liposarcoma ...

  13. Dedifferentiated Liposarcoma in the Retroperitoneum in an Atomic Bomb Survivor: Report of a Case

    OpenAIRE

    Nakamura, Yukio; Yumiba, Takeyoshi; Yamasaki, Yoshio; Momiyama, Takuya; Ito, Akira; Akamaru, Yusuke; Kasugai, Tsutomu

    2008-01-01

    A 76-year-old Japanese man was admitted to Kosei-Nenkin Hospital (Osaka, Japan) in November 2006; his chief complaint was a 10-kg loss in body weight over 3 months prior to admission. Abdominal computed tomography (CT) and dynamic magnetic resonance imaging (MRI) showed three masses in the retroperitoneum. The patient subsequently underwent surgery. The final histopathological diagnosis of tumors 1 and 2 was malignant fibrous histiocytoma of the retroperitoneum, and tumor 3 was a well-differe...

  14. Liposarcoma of the chest wall. Transformation of dedifferentiated liposarcoma from a recurrent lipoma.

    OpenAIRE

    Pinar Bicakcioglu; Sak, Serpil D.; Tastepe, Abdullah I.

    2012-01-01

    Liposarcoma is the second most common soft tissue sarcoma after malignant fibrous histiocytoma in adults. It is frequently found in the extremities and retroperitoneum; rarely it can be seen in the chest wall. We report a rare case of giant liposarcoma originating from the chest wall representing a transformation of a relapsing lipoma in the same region. We performed chest wall resection, reconstruction with latissimus dorsi muscle transposition via posterolateral thoracotomy. The patient rec...

  15. Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue.

    OpenAIRE

    Swanson, P. E.; Manivel, J. C.; Wick, M. R.

    1987-01-01

    Monoclonal antibodies to Leu-7 have been reported to recognize a constituent of myelin-associated glycoprotein. Because of this, the authors studied 20 cases of neurofibrosarcoma (NFS), 7 of leiomyosarcoma (LMS), 3 of fibrosarcoma (FS), 8 of malignant fibrous histiocytoma (MFH), 5 of monophasic spindle cell synovial sarcoma (MSS), 5 of neurilemmoma, and 5 of neurofibroma for Leu-7 reactivity, to determine its utility in differential diagnosis. Selected examples of each tumor type were also st...

  16. Focal fibrous hyperplasia: A review of 193 cases

    Science.gov (United States)

    de Santana Santos, Thiago; Martins-Filho, Paulo Ricardo Saquete; Piva, Marta Rabello; de Souza Andrade, Emanuel Sávio

    2014-01-01

    Context: Focal fibrous hyperplasia, also known as irritation or traumatic fibroma, is a reactive, inflammatory hyperplastic lesion of the connective tissue. Aim: The aim of this study is to perform a retrospective study of a focal fibrous hyperplasia of 18 years. Materials and Methods: We retrospectively reviewed 193 cases of focal fibrous hyperplasia of the oral cavity from the medical and histological reports of the Department of Oral Pathology, Pernambuco University, Brazil, during the period between January 1992 and December 2009. Settings and Design: Data with regard to age, gender, location, size of the lesion (equal to or less than 1 cm, between 1 and 2 cm and greater than 2 cm), pain, history of trauma, treatment, length of follow-up (from diagnosis to release or last review) and recurrence, were collected. Results: The most commonly affected site was the buccal mucosa (n = 119, 61.7%). Almost two-thirds of the cases were concentrated from the second to the fifth decade of life. Females were more affected than men and a history of trauma was related by 90.7% of the patients. Two recurrences were notified (1.0%). Conclusion: Further studies are needed on the distribution of the lesion in different ethnic and geographical populations. The influence of sex hormones on the development of focal fibrous hyperplasia must be clarified. PMID:25364187

  17. An improved automotive brake lining using fibrous potassium titanate

    Science.gov (United States)

    Mansfield, J. A.; Halberstadt, M. L.; Riccitiello, S. R.; Rhee, S. K.

    1976-01-01

    Simultaneous fade reduction and wear improvement of a commercial automotive brake lining were achieved by adding fibrous potassium titanate. The dependence of friction and wear characteristics on quantitative variations in potassium titanate, asbestos, phenolic binder, and organic and inorganic modifiers was evaluated.

  18. Calcifiying fibrous pseudotumor of the small bowel mesentery - case report.

    Science.gov (United States)

    Paszkiewicz, Izabela; I?ycka-?wieszewska, Ewa; Wysocki, Tomasz; Dobosz, Lukasz; Dobosz, Marek

    2014-06-01

    Calcifiyng fibrous pseudotumor (CFPT) is a benign mesenchymal tumor diagnosed in children and young adults, located in the subcutaneous tissue of the trunk and limbs. Its intraabdominal localization is a unique rarity. The Authors of the study presented a case of a 48-year old female patient with an accidentally diagnosed small bowel mesentery tumor during surgery. PMID:25205701

  19. Calcifiying Fibrous Pseudotumor of the Small Bowel Mesentery – Case Report

    Directory of Open Access Journals (Sweden)

    Paszkiewicz Izabela

    2014-06-01

    Full Text Available Calcifiyng fibrous pseudotumor (CFPT is a benign mesenchymal tumor diagnosed in children and young adults, located in the subcutaneous tissue of the trunk and limbs. Its intraabdominal localization is a unique rarity. The Authors of the study presented a case of a 48-year old female patient with an accidentally diagnosed small bowel mesentery tumor during surgery

  20. [Giant retroperitoneal solitary fibrous tumor: report of a case].

    Science.gov (United States)

    Gutiérrez Miranda, Luis Santiago; Grández-Urbina, José Antonio

    2013-01-01

    Giant solitary fibrous tumor (TFSG) is a spindle cell neoplasm, uncommon, being pleural a common site. We report a case of chronic presentation of 4 months duration with a palpable mass. We found, a tumor 35 x 20 x 15 cm .In the literature tumors diagnosed as TFSG are very rare, the first reported in our country. PMID:24108381

  1. Examination of compression and resilience characteristics of fibrous insulation blankets

    International Nuclear Information System (INIS)

    Load-deflection characteristics of alumina and alumino-silicate fibrous blankets were experimentally determined. Load retention and springback capability of combinations of these materials were measured in a 10,000-hour test at surface temperatures of 650 to 10000C (1200 to 18320F). Experimental results are presented and future testing plans are discussed

  2. Ultrasonographic Localization of Solitary Fibrous Tumor of Pleura: Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyoung Tae; Jeon, Yong Sun; Cho, Soon Gu; Kim, Kwang Ho; Lee, Kyung Hee [Inha University School of Medicine, Incheon (Korea, Republic of)

    2010-03-15

    Plain radiography and computed tomography are widely used in the field of chest disease. Yet ultrasonography has a limitation as a diagnostic tool, except in the case of pleural effusion and chest wall lesion. We experienced a case of solitary fibrous tumor of the diaphragmatic pleura, and the origin of this tumor could be exactly localized by ultrasonography, but not by other imaging modalities

  3. Fibrous papule of the face with granular cells.

    Science.gov (United States)

    Jacyk, W K; Rütten, A; Requena, L

    2008-01-01

    Fibrous papule of the face is a common benign lesion located most often on the nose. It presents usually as a single small, firm, skin-coloured papule and is often misdiagnosed as melanocytic naevus, wart or small nodular basal cell carcinoma. Histopathologically, the lesions are characterized by involvement of the upper dermis by a fibrovascular proliferation and scattered triangular or stellate, often multinucleated cells. Uncommon histopathologic variants of fibrous papule of the face include hypercellular, clear-cell, pleomorphic, pigmented, inflammatory and granular-cell types. We present here a patient with the syndrome of familial cancer and fibrous papule of the face with granular cells. The granules stained strongly with PAS stain, as well as with CD68 and NKI/C3 immunostains, whereas S-100 protein resulted negative. In our patient the mutations in the 2 most often affected DNA mismatch repair genes of Muir-Torre syndrome were not found, therefore the origin of the familial cancer syndrome remains unknown. Probably the occurrence of the granular-cell fibrous papule of the face was coincidental. PMID:18032900

  4. Malignant chondroid syringoma

    Directory of Open Access Journals (Sweden)

    Shashikala P

    2004-05-01

    Full Text Available An adult female presented with a painful recurrent swelling on the posterior aspect of the scalp of six months? duration, which was clinically diagnosed as fibroma. An excision biopsy showed anaplastic epithelial cells arranged in irregular cords and trabeculae, mitosis, malignant chondroid areas, desmoplasia and perineural invasion, suggesting malignancy. Wide excision of the tumor was the only treatment given since there was no metastasis.

  5. Hypercalcemia in malignancy.

    OpenAIRE

    Strewler, G. J.; Nissenson, R. A.

    1990-01-01

    The pathogenesis of hypercalcemia in malignancy has been enigmatic until recent years. Since the realization in 1980 that bioassays for parathyroid hormone detected a cross-reacting substance in malignancy, progress has been remarkably rapid. A parathyroid hormone-related protein was purified and identified by molecular cloning as a 141-amino acid peptide with limited homology to parathyroid hormone itself. Nonetheless, both peptides activate the parathyroid hormone receptor to produce hyperc...

  6. AIDS-related malignancies.

    OpenAIRE

    Spittle, M. F.

    1996-01-01

    The management of AIDS-related malignancies demands that the cancer must be treated in the context of patients already suffering from a fatal disease. Management must be problem-orientated. The standard cancer treatment of such a patient may not be appropriate in the AIDS setting. The AIDS related malignancies are Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma (NHL) including primary cerebral lymphoma. Carcinoma of the cervix was recently added to this list, but has not been seen in this co...

  7. Malignant eccrine poroma.

    OpenAIRE

    Ansari, Naseem A.

    2005-01-01

    ABSTRACT Benign eccrine poroma arises from the intraepidermal portion of the eccrine gland duct. Malignant transformation is rare and should be suspected when these lesions present with pain, bleeding or itching. We report a 44-year-old male patient who presented primarily with a lesion diagnostic of benign eccrine poroma of the right foot sole with no clear evidence of malignancy, which was incompletely excised, followed 5 months later by local recurrence, ulceration, occasional bleeding ...

  8. [Malignant nail tumors].

    Science.gov (United States)

    Haneke, E

    2014-04-01

    Because of the large number of different tissues making up the distal phalanx of fingers and toes, a large variety of malignant tumors can be found in and around the nail apparatus. Bowen disease is probably the most frequent nail malignancy. It is usually seen as a verrucous plaque of the nail fold and nail bed in persons above the age of 40 years. It slowly grows over a period of years or even decades before degenerating to an invasive squamous cell carcinoma. The latter may also occur primarily often as a weeping onycholysis. The next most frequent nail malignancy is ungual melanoma. Those arising from the matrix are usually pigmented and often start with a longitudinal melanonychia whereas those originating from the nail bed remain amelanotic, are often nodular and mistaken for an ingrown nail in an elderly person. The treatment of choice for in situ and early invasive subungual melanomas is generous extirpation of the nail apparatus whereas distal amputation is only indicated for advanced melanomas. In addition to these frequent nail malignancies, nail-specific carcinomas, malignant vascular and osseous tumors, other sarcomas, nail involvement in malignant systemic disorders and metastases may occur. In most cases, they cannot be diagnosed accurately on clinical grounds. Therefore, a high degree of suspicion is necessary in all isolated or single-digit proliferations that do not respond to conservative treatment. PMID:24718507

  9. Amelanotic malignant melanoma presenting as malignant schwannoma.

    Science.gov (United States)

    Schadendorf, D; Haas, N; Worm, M; Ostmeier, H; Kohlmus, C; Gottschalk, J; Algermissen, B; Jautzke, G; Czarnetzki, B M

    1993-11-01

    A 78-year-old woman presented with a 14-month history of a nodule on the sole of her left foot. It had been increasing in size, and had become ulcerated. Histological, immunochemical and ultrastructural studies of the primary tumour revealed melanocytic and Schwannian characteristics, and posed diagnostic difficulties. The final diagnosis of a malignant melanoma with Schwannian differentiation was established on the basis of the clinical course, with the development of metastases in the subcutis, lymph nodes, liver and brain, as well as a shift in differentiation of the metastases towards cells containing giant melanosomes, typical of melanoma. PMID:8251363

  10. Primary Malignant Tumours of Bone Following Previous Malignancy

    Directory of Open Access Journals (Sweden)

    R. J. Grimer

    2008-04-01

    Full Text Available Destructive bone lesions occurring in patients who have previously had a malignancy are generally assumed to be a metastasis from that malignancy. We reviewed 60 patients with a previous history of malignancy, who presented with a solitary bone lesion that was subsequently found to be a new and different primary sarcoma of bone. These second malignancies occurred in three distinct groups of patients: (1 patients with original tumours well known to be associated with second malignancies (5%; (2 patients whose second malignancies were likely to be due to the previous treatment of their primary malignancy (40%; (3 patients in whom there was no clearly defined association between malignancies (55%. The purpose of this study is to emphasise the necessity for caution in assuming the diagnosis of a metastasis when a solitary bone lesion is identified following a prior malignancy. Inappropriate biopsy and treatment of primary bone sarcomas compromises limb salvage surgery and can affect patient mortality.

  11. Tumor fibroso solitário do rim: descrição de caso / Solitary fibrous tumor of the kidney: a case report

    Scientific Electronic Library Online (English)

    Giovani Rodrigues, Batista; Giuseppe, D' Ippolito; Jacob, Szejnfeld; Suzan, Menasce; Marcos Tadeu l., Fischman; Renato Lima de, Moraes Junior.

    2005-08-01

    Full Text Available Apresentamos um caso de tumor renal num paciente de 27 anos de idade, que foi submetido a estudo de imagem por tomografia computadorizada e ressonância magnética. As características radiológicas da massa induziam para um diagnóstico de tumor renal maligno de origem intraparanquimatosa. No entanto, o [...] estudo histopatológico revelou tumor fibroso solitário benigno originário da pelve e porção calicial do rim direito. Abstract in english We present a case of a 27-year-old male patient submitted to computed tomography and magnetic resonance imaging for the evaluation of a renal tumor. The radiological features of the mass suggested the diagnosis of a malignant renal tumor of parenchymatous origin. However, the histological findings p [...] roved to be a benign solitary fibrous tumor within the pelvis and caliceal portion of the right kidney.

  12. Tumor fibroso solitário do rim: descrição de caso Solitary fibrous tumor of the kidney: a case report

    Directory of Open Access Journals (Sweden)

    Giovani Rodrigues Batista

    2005-08-01

    Full Text Available Apresentamos um caso de tumor renal num paciente de 27 anos de idade, que foi submetido a estudo de imagem por tomografia computadorizada e ressonância magnética. As características radiológicas da massa induziam para um diagnóstico de tumor renal maligno de origem intraparanquimatosa. No entanto, o estudo histopatológico revelou tumor fibroso solitário benigno originário da pelve e porção calicial do rim direito.We present a case of a 27-year-old male patient submitted to computed tomography and magnetic resonance imaging for the evaluation of a renal tumor. The radiological features of the mass suggested the diagnosis of a malignant renal tumor of parenchymatous origin. However, the histological findings proved to be a benign solitary fibrous tumor within the pelvis and caliceal portion of the right kidney.

  13. MALIGNANT SALIVARY GLAND TUMORS

    Directory of Open Access Journals (Sweden)

    Violeta Trandafir

    2010-05-01

    Full Text Available Malignant salivary gland tumors make up 6% of all head and neck tumors. Several types of cancer can develop in these glands. Only malignant tumors of the salivary glands are discussed in this paper. The diagnosis and treatment of salivary gland malignancies remain complex, with challenging problems for maxillo-facial surgeon. Scientists have found few risk factors that make a person more likely to develop salivary gland cancer. Salivary gland cancer is uncommon, and there is no widely recommended screening schedule for this cancer. CT scanning or MRI is useful for determining the extent of large tumors, for evaluating extraglandular extension, for determining the actual depth of parotid tumors, and for discovering other tumors in one gland or in the controlateral gland. Fine-needle aspiration biopsy (FNAB is a valuable diagnostic adjunct in evaluation of head and neck masses but its role in evaluation of salivary gland tumors is controversial. There are also discussed some histologic findings about mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, carcinoma ex-pleomorphic adenoma, squamous cell carcinoma and adenocarcinoma developed in salivary glands. Carefully planned and executed surgical excision is the primary treatment for all malignant tumors of the salivary glands. The principles of surgery vary with the site of origin. The extent of surgery is based on the size of the tumor, local extension and neck metastases. Staging of malignant salivary gland tumors is important for predicting prognosis and for accurate comparison of treatment results.

  14. Fibrous dysplasia mimicking bone metastasis on both bone scintigraphy and {sup 18}F FDG PET CT: Diagnostic dilemma in a patient with breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    KC, Sud Hir Suman; Sharma, Punit; Singh, Har Man Deep; Bal, Chand Rasekhar; Kumar, Rake Sh [India Institute of Medical Sciences, New Delhi (India)

    2012-12-15

    Bone is the most common distant site to which breast cancer metastasizes. Commonly used imaging modalities for imaging bone metastasis are bone scintigraphy, plain radiography, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Although bone scintigraphy gas high sensitivity for detecting bone metastasis, its specificity is low. This is because of the fact that bone scintigraphy images secondary changes in bone rather than just tumor cells {sup 18}F fluorodeoxyglucose ({sup 18}F FDG) PET CT, on the other hand, directly images the tumor cells' glucose metabolism. Unfortunately, similar to bone scintigraphy, benign bone conditions can also show increased {sup 18}F FDG uptake on PET CT, and PET positive asymptomatic fibrous dysplasia can be misinterpreted as a metastasis. Fibrous dysplasia of bone has wide skeletal distribution, with variability of {sup 18}F FDG uptake and CT appearance. It is therefore important to recognize the characteristics of this skeletal dysplasia, to allow differentiation from skeletal metastasis. Bone lesions with {sup 18}F FDG uptake need to be carefully interpreted when evaluating patients with known malignancy. In doubtful cases, fibrous dysplasia should be given as a differential diagnosis and histopathological diagnosis may be warranted, as highlighted in the present case.

  15. Malignant vagal paraganglioma.

    Science.gov (United States)

    Righi, Stefano; Boffano, Paolo; Malvè, Laura; Pateras, Dimitrios; Chiodo, Domenico; Boson, Maurizio

    2014-09-01

    The purpose of this paper is to present and discuss a new case of malignant vagal paraganglioma. A 38-year-old woman was referred for the assessment of a bilateral firm cervical mass. CT scans revealed a left cervical ovoid mass; contralaterally, a mass with a similar enhancement could be observed too. The tumor was surgically removed via a transcervical surgical approach, together with levels I to III lymph nodes. Definitive histopathological examination proved the diagnosis of malignant vagal paraganglioma with contralateral cervical lymph node metastasis. One year after surgery, a PET-CT and a scintigraphy revealed the presence of a cervical recurrence and hepatic metastasis. Three months after a second surgical intervention, the patient died. Malignant vagal paraganglioma is a rare and challenging lesion that has to be carefully assessed to plan an appropriate treatment. A strict follow-up is fundamental for an early diagnosis of eventual recurrences. PMID:25148625

  16. Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues

    Directory of Open Access Journals (Sweden)

    Steinau Hans-Ulrich

    2006-07-01

    Full Text Available Abstract Background Solitary fibrous tumors (SFT represent a rare entity of soft tissue tumors. Previously considered being of serosal origin and solely limited to the pleural cavity the tumor has been described in other locations, most particularly the head and neck. Extrathoracic SFT in the soft tissues of the trunk and the extremities are very rare. Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and treatment results. Methods Data were obtained from patients' records, phone calls to the patients' general practitioners, and clinical follow-up examination, including chest X-ray, abdominal ultrasound, and MRI or computed tomography. Results There were 6 females and 3 males, whose age at time of diagnosis ranged from 32 to 92 years (mean: 62.2 years. The documented tumors' size was 4.5 to 10 cm (mean: 7 cm. All tumors were located in deep soft tissues, 3 of them epifascial, 2 subfascial, 4 intramuscular. Four tumors were found at the extremities, one each at the flank, in the neck, at the shoulder, in the gluteal region, and in the deep groin. Two out of 9 cases were diagnosed as atypical or malignant variant of ESFT. Complete resection was performed in all cases. Follow-up time ranged from 1 to 71 months. One of the above.mentioned patients with atypical ESFT suffered from local relapse and metastatic disease; the remaining 8 patients were free of disease. Conclusion ESFT usually behave as benign soft tissue tumors, although malignant variants with more aggressive local behaviour (local relapse and metastasis may occur. The risk of local recurrence and metastasis correlates to tumor size and histological status of surgical resection margins and may reach up to 10% even in so-called "benign" tumors. Tumor specimens should be evaluated by experienced soft tissue pathologists. The treatment of choice is complete resection followed by extended follow-up surveillance.

  17. A 40-year-old gossypiboma (foreign body granuloma) mimicking a malignant femoral surface tumor

    Energy Technology Data Exchange (ETDEWEB)

    Sakayama, Kenshi; Fujibuchi, Taketsugu; Kidani, Teruki; Miyawaki, Joji; Yamamoto, Haruyasu [Ehime University School of Medicine, Department of Orthopaedic Surgery, Ehime (Japan); Sugawara, Yoshifumi [Ehime University School of Medicine, Department of Radiology, Ehime (Japan)

    2005-04-01

    The patient was a 61-year-old man who developed gossypiboma of the left thigh and femur resulting in the imaging appearances of a malignant surface tumor. He had a past history of surgery on the left femur for open fracture 40 years previously. Radiographs and CT showed a soft tissue mass with osteolysis and periosteal thickening of the left femur. On MRI, the mass showed heterogeneous signal intensity with contrast enhancement at the periphery, suggesting a malignancy. {sup 99m}Tc-HMDP bone scintigraphy showed a faint ring-like uptake, but thallium -201 scintigraphy did not show any uptake in the tumor. An extensive intralesional excision was performed. Postoperative histopathological examination showed a fibrous foreign body with reactive changes. There were neither viable cells nor atypical giant cells around the foreign body. No malignant change was evident. Based on surgical and histopathological examinations, the tumor was finally diagnosed as gossypiboma related to a retained surgical sponge. (orig.)

  18. A 40-year-old gossypiboma (foreign body granuloma) mimicking a malignant femoral surface tumor

    International Nuclear Information System (INIS)

    The patient was a 61-year-old man who developed gossypiboma of the left thigh and femur resulting in the imaging appearances of a malignant surface tumor. He had a past history of surgery on the left femur for open fracture 40 years previously. Radiographs and CT showed a soft tissue mass with osteolysis and periosteal thickening of the left femur. On MRI, the mass showed heterogeneous signal intensity with contrast enhancement at the periphery, suggesting a malignancy. 99mTc-HMDP bone scintigraphy showed a faint ring-like uptake, but thallium -201 scintigraphy did not show any uptake in the tumor. An extensive intralesional excision was performed. Postoperative histopathological examination showed a fibrous foreign body with reactive changes. There were neither viable cells nor atypical giant cells around the foreign body. No malignant change was evident. Based on surgical and histopathological examinations, the tumor was finally diagnosed as gossypiboma related to a retained surgical sponge. (orig.)

  19. Malignant system diseases

    International Nuclear Information System (INIS)

    Following a brief survey on the not entirely clear aetiology of the malignant system diseases, their epidemiology and histology, as well as the clinic and treatment fundamentals. The author deals with malignant lymphoma and the myeloproliferative diseases in two special sections. In the case of lymphoma he distinguishes between the treatment of Hodgkin lymphoma and non-Hodgkin lymphoma and gives a survey on the histology, various stages, performance of radiotherapy with therapy plan, as well as prognoses and results. The myeloproliferative diseases are treated according to their individual forms (acute, chronic, myeloic leukemia and chronic lymphatic leukemia, osteomyelosklerosis, polycythaemic vera, plasmocytoma and eosinophile granulom) and the corresponding form of radiotherapy. (MG)

  20. Solitary fibrous tumor of the thigh with epithelioid features: a case report

    Directory of Open Access Journals (Sweden)

    Garcia-Garcia Jose

    2007-06-01

    Full Text Available Abstract Background Extrapleural Solitary Fibrous tumors (SFTs have been increasingly reported. The retroperitoneum, deep soft tissues of proximal extremities, abdominal cavity, trunk, head and neck are the most common extraserosal locations reported. Microscopically they show a wide range of morphological features, and so the differential diagnosis is extensive. Immunohistochemically, they commonly express CD34, vimentin, bcl-2 and CD99. Epithelial membrane antigen (EMA and smooth muscle actin (SMA may occasionally be expressed. Epithelioid morphology in extrapleural SFT has only very occasionally been described (five cases reported, some of them with biphasic pattern and others with malignant characteristics. Case presentation A SFT of the thigh with epithelioid areas in a 63 year old woman is reported. Microscopically the tumor showed areas hypo and hipercellular. At the periphery of the hipercellular areas there were nodules composed of epithelioid cells. Immunohistochemically both the spindle and epithelioid cells were positive for CD34, vimentin, bcl-2 and CD99. Epithelial, neural and muscular markers were negative. Molecular study was done and ruled out a synovial sarcoma. Conclusion Ten cases of SFT of the thigh have been reported but to our knowledge this is the first case with epithelioid morphology affecting the extremities. Identification of this pattern of SFT is of importance, to avoid misdiagnosis with other more aggressive conditions in soft tissue.

  1. Endoscopic resection of solitary fibrous tumors of the nose and paranasal sinuses.

    Science.gov (United States)

    Janjua, Arif; Sklar, Michael; Macmillan, Christina; Vescan, Allan; Witterick, Ian J

    2011-03-01

    Solitary fibrous tumors (SFTs) are uncommon neoplasms of mesenchymal origin that were first described as primary spindle-cell tumors of the pleura in 1931. Since then, infrequent case reports of extrapleural SFTs have been described including various subsites within the head and neck. Based on a review of the literature and a description of the endoscopic treatment of three patients with SFTs of the nasal cavity and ethmoid sinuses, the challenges associated with the management of sinonasal SFTs are discussed. Successful endoscopic resection was performed at a tertiary referral rhinology practice within a university center in three cases of sinonasal SFTs with no evidence of recurrence at 26, 35, and 49 months following resection. Summarized are the common presenting symptoms, appropriate diagnostic workup, and indicative computed tomography and magnetic resonance imaging appearance of SFTs. Further discussed are the challenge associated with accurate histological and immunohistochemical diagnosis, the difficulty in assessing the aggressiveness and malignant potential of these lesions, and the appropriate treatment and follow-up duration that these neoplasms require. PMID:22451814

  2. Solitary fibrous tumor of the kidney: a case report.

    Science.gov (United States)

    Demirta?, Abdullah; Sabur, Volkan; Akgün, Hülya; Ak?nsal, Emre Can; Demirci, Deniz

    2013-01-01

    Solitary fibrous tumor is a spindle cell neoplasm mostly originating from pleura; however, it has also recently been reported to be extrapleural. A 57-year-old man presented with left lumbal pain. Ultrasonography and computed tomography showed a cystic lesion of 14 × 11?cm with solid areas and septations in middle and lower poles of the left kidney. Radical nephrectomy was performed. Immunohistochemical studies showed strong reactions with CD34 and CD99. A nuclear positivity with Ki-67 was observed in less than 1% of cells. Despite repeated stainings with vimentin, no clear tumor evaluation could be made due to artifacts. The tumor was negative with Bcl-2, desmin, HMB-45, S100, FVIII, and CD31. Histopathological and molecular studies made the diagnosis of a solitary fibrous tumor. The patient is now currently free of disease at the 26th month of followup. PMID:23662242

  3. Aging-caused changes in optical anisotropy of fibrous tissues

    Science.gov (United States)

    Mikhailova, Alyona D.; Ermolenko, Sergey B.; Zimnyakov, Dmitry A.; Angelsky, Oleg V.

    2009-10-01

    Energy density approach as a modification of the coherent potential approximation was applied to analyze the influence of aging-caused changes in the fibrous tissue on its birefringence. The real fibrous tissue such as tendon was modeled by disordered array of partially oriented dielectric cylinders illuminated by a normally incident linearly polarized plane wave. The supraspinatus human tendon was taken as an object for theoretical modeling. The morphological features of the studied tissue were considered for a system of collagen fiber bundles embedded in a carbohydrate matrix. The latter one is a mixture of glycosaminoglycans and proteoglycans. Age-caused changes of the fibers and matrix influence on the spectral dependence of optical anisotropy spectrum.

  4. Fibrous protein-based hydrogels for cell encapsulation.

    Science.gov (United States)

    Silva, Raquel; Fabry, Ben; Boccaccini, Aldo R

    2014-08-01

    Tissue scaffolds play a vital role in tissue engineering by providing a native tissue-mimicking environment for cells, with the aim to promote cell proliferation, proper cell differentiation, and regeneration. To better mimic the microenvironment of native tissues, novel techniques and materials have emerged in recent years. Among them, hydrogels formed from self-assembled biopolymer networks are particularly interesting. This paper reviews the fabrication and use of fibrous protein-based hydrogels, with an emphasis on silk, keratin elastin and resilin proteins. Hydrogels formed by these proteins show close structural, chemical and mechanical similarities with the extracellular matrix, typically good biological compatibility, and they can trigger specific cellular responses. In addition, these hydrogels can be degraded in the body by proteolytic enzymes. For these reasons, fibrous protein hydrogels are one of the most versatile materials for tissue engineering. PMID:24836951

  5. Solitary Fibrous Tumor of the Kidney: A Case Report

    OpenAIRE

    Abdullah Demirta?; Volkan Sabur; Hülya Akgün; Nsal, Emre Can Ak Amp X.; Deniz Demirci

    2013-01-01

    Solitary fibrous tumor is a spindle cell neoplasm mostly originating from pleura; however, it has also recently been reported to be extrapleural. A 57-year-old man presented with left lumbal pain. Ultrasonography and computed tomography showed a cystic lesion of 14 × 11?cm with solid areas and septations in middle and lower poles of the left kidney. Radical nephrectomy was performed. Immunohistochemical studies showed strong reactions with CD34 and CD99. A nuclear positivity with Ki-67 was...

  6. Carbon-based fibrous EDLC capacitors and supercapacitors

    OpenAIRE

    Watts, J. F.; Andrews, T.; Markoulidis, F.; Moudam, O.; Lekakou, C.; Reed, G. T.

    2011-01-01

    This paper investigates electrochemical double-layer capacitors (EDLCs) including two alternative types of carbon-based fibrous electrodes, a carbon fibre woven fabric (CWF) and a multiwall carbon nanotube (CNT) electrode, as well as hybrid CWF-CNT electrodes. Two types of separator membranes were also considered. An organic gel electrolyte PEO-LiCIO4-EC-THF was used to maintain a high working voltage. The capacitor cells were tested in cyclic voltammetry, charge-discharge, and impedance test...

  7. Solitary fibrous tumour of the adrenal gland associated with pregnancy.

    OpenAIRE

    Morino, Mario

    2000-01-01

    Solitary fibrous tumour (SFT), first described as a pleural lesion, has been reported in several extrathoracic sites over the past 10 years. We describe a SFT of the left adrenal gland incidentally discovered in a 23-year-old, 22-week pregnant woman and characterised by a rapid growth during the third trimester of pregnancy. Elevated serum and urinary levels of cortisol and elevated blood levels of delta 4 androstendione and 17-OH progesterone were observed. After spontaneous delivery, the pa...

  8. Unilateral femoral deformity due to a focal fibrous tether

    International Nuclear Information System (INIS)

    The purpose of this paper is to assess the radiological features of the unilateral angular deformity of the distal end of the femur secondary to a focal fibrous tether. Only five cases of this entity have been reported in the literature. We report another two patients. Magnetic resonance study was performed on one of them, which has not been used in previous cases. Both cases are described with illustrations of the typical radiographic appearances supplemented by CT and MR imaging. (orig.)

  9. Clinicoradiologic perspective of a severe case of polyostotic fibrous dysplasia

    OpenAIRE

    Sandhu, Simarpreet V.; Sandhu, Jagpreet Singh; Sabharwal, Amarpreet

    2012-01-01

    Fibrous dysplasia (FD) of bone is a congenital non-heritable disorder that was first reliably reported by von Recklinghausen, when he described patients with pathologic condition of bone characterized by deformity and fibrotic changes that he termed as osteitis fibrosa generalisata. FD may involve one bone (monostotic) or multiple bones (polyostotic) and occurs throughout the skeleton with predilection for long bones, ribs, and cranio-facial bones. Seventy percent of the lesions are monostoti...

  10. Radiologic Features of Fibrous Hamartoma of Infancy Involving the Buttocks

    International Nuclear Information System (INIS)

    Fibrous hamartoma of infancy (FHI) is a rare benign subcutaneous tumor that presents in children younger than two years. The tumor mostly affects the trunk, axilla and upper extremities. Imaging findings of FHI that involve the buttocks have not been reported in the clinical literature. We reported the imaging features of a lesion in a 9-month-old infant who presented with a palpable mass on the buttocks. The imaging findings were evaluated after a review of previous studies

  11. High strength and ductile fibrous concrete of enhanced fire resistance

    OpenAIRE

    Lourenc?o, Lu?cio; Barros, Joaquim A. O.; Santos, S. P. F.

    2007-01-01

    In the present work a Fiber Reinforced Concrete of Enhanced Fire Resistance (FRCEFR) was developed and its properties are characterized by experimental research. This concrete is intended to have enough resistance for the most structural engineering applications and is reinforced with a fibrous system to assure the necessary ductility and to improve its fire resistance. Two types of fibers are used to accomplish the aforementioned requisites for the concrete. The research perfo...

  12. Solitary Fibrous Tumor Arising from the Sphenoid Sinus

    OpenAIRE

    Haruo Takahashi; Naoe Kinoshita; Tomayoshi Hayashi; Takeshi Watanabe; Kenji Takasaki; Hidetaka Kumagami

    2009-01-01

    Solitary fibrous tumor (SFT) is an uncommon neoplasm that usually arises from the pleura. To our knowledge, only 30 cases of SFTs in the nasal cavity and paranasal sinuses have been reported in the literature. We describe an SFT that arose from the right sphenoid sinus and extended to the nasal cavity and epipharynx. The tumor was completely removed by endoscopic sinus surgery without complication. The patient is taking an uneventful course without any evidence of recurrence of the disease 8 ...

  13. Directionally oriented fibrous structures for llghtweight concrete elements reinforcement

    OpenAIRE

    Fangueiro, Rau?l; Marques, P.; Pereira, C. Gonilho

    2010-01-01

    This paper reports on the work that is being undertaken at the University of Minho concerning the development of directionally oriented fibrous structures (DOFS) to be used as a concrete reinforcement material. Several glass fibre wovenlike DOFS were produced varying two parameters: roving linear density (tex) and reinforcement structural density (rovings/ cm). Self-compacting concrete slabs were reinforced by DOFS structures and their bending behaviour was evaluated. The resul...

  14. Recurring fibrous dysplasia of anthro maxillary with cranial base invasion

    OpenAIRE

    Sousa, Ka?tia Maria Marabuco; Costa, Ka?rlos Jader Sa?tiro Mendonc?a; Holanda, Thiago Ayres; Silva, Thiago Oliveira E.; Cunha, Rafael Levi Louchar Silva Da; Soares, Vi?tor Yamashiro Rocha

    2009-01-01

    Introduction: Fibrous dysplasia is an osseous lesion with an unknown etiology. It is characterized by the osseous maturation insufficiency. It may affect any bone, but the affection of craniofacial bones is the most critical for otorhinolaryngology. Maxilla is the most affected facial bone and the orbitary invasion is an uncommon event. The symptoms are unspecific and for its low suspicion and uncommonness, the diagnosis is generally late. The monostotic form presents a slow growth and asympt...

  15. Rapid reconstruction of 3D structure of fibrous media

    OpenAIRE

    Berejnov, Viatcheslav; Sinton, David; Djilali, Ned

    2009-01-01

    Characterization of transport properties of porous media is increasingly relying on computational methods that require reconstruction of the media structure. We present a simple method of constructing the 3D surface of fibrous porous media - the gas diffusion layer (GDL) used as the porous electrode in PEM fuel cells. The method is based on extending the depth-of-field on the whole attainable thickness of the GDL. A series of images of the GDL sample is recorded by the seque...

  16. Erosive separation of organic coatings from fibrous substrates.

    Science.gov (United States)

    Weiss, M; Momber, A W

    2004-11-01

    The separation of organic coatings from fibrous substrates is a key problem in recycling processes. This problem applies to carpets, technical textiles and automotive interior components. This paper reports about results of laboratory studies involving the application of high-speed liquid jets to solve this problem. Results from high-speed video images are used to qualify the principal erosion process. It is shown that the coating material is first ground by the jet; the generated erosion debris is then pushed through the permeable fibrous fabric of the substrate. It is also found that threshold conditions exist for the coating grinding process and for the debris transportation. These threshold conditions depend on target composition and process parameters. A phenomenological separation model is introduced. The influence of key process parameters, namely jet velocity, exposure time, stand-off distance and impact angle, is also investigated. It is found that high-speed liquid jets are suitable tools for separating organic coatings completely and selectively from fibrous substrates. Recommendations on how to optimise the erosion process are derived from the results. PMID:15474739

  17. Malignant melanoma (metastatic)

    OpenAIRE

    Larkin, James; Gore, Martin

    2008-01-01

    There are 8100 new cases of malignant melanoma and 1800 deaths a year in the UK, largely as a result of metastatic disease. The median survival of people with metastatic melanoma is 6 to 9 months after diagnosis, with 10% of people alive at 5 years.Chemotherapy is given with palliative rather than curative intent for metastatic disease.

  18. Malignant pleural mesothelioma

    Directory of Open Access Journals (Sweden)

    Rao Sukhesh

    2009-01-01

    Full Text Available Malignant mesothelioma is one of the rare tumors of pleura. One such case in a 57-year-old male, who presented with hemorrhagic pleural effusion and had no history of asbestos exposure, is reported here. The rarity, unusual presentation, and implications are discussed.

  19. Malignant pleural mesothelioma

    International Nuclear Information System (INIS)

    Malignant pleural mesotheliomas are a rare disease of unknown origin. In some regions they were of frequent occurence after asbestos exposure. It is difficult to obtain an exact diagnosis because of the polymorphic appearance of the tumor. Above all radiological methods are appropriate for the diagnosis. By means of an unusual course of this disease clinical symptoms and diagnostical possibilities are discussed. (orig.)

  20. Aggressive malignant phyllodes tumor

    Directory of Open Access Journals (Sweden)

    Nathan Roberts

    2015-01-01

    Conclusion: Despite biopsy proven malignant phyllodes tumor, it was near impossible to predict such a rapid course of disease progression in our patient. Our case illustrates the unpredictable nature of this disease in general and it possibly sheds light on a variant of the disease which had undergone an aggressive transformation.

  1. Immunotherapy for malignant glioma.

    Science.gov (United States)

    Suryadevara, Carter M; Verla, Terence; Sanchez-Perez, Luis; Reap, Elizabeth A; Choi, Bryan D; Fecci, Peter E; Sampson, John H

    2015-01-01

    Malignant gliomas (MG) are the most common type of primary malignant brain tumor. Most patients diagnosed with glioblastoma (GBM), the most common and malignant glial tumor, die within 12-15 months. Moreover, conventional treatment, which includes surgery followed by radiation and chemotherapy, can be highly toxic by causing nonspecific damage to healthy brain and other tissues. The shortcomings of standard-of-care have thus created a stimulus for the development of novel therapies that can target central nervous system (CNS)-based tumors specifically and efficiently, while minimizing off-target collateral damage to normal brain. Immunotherapy represents an investigational avenue with the promise of meeting this need, already having demonstrated its potential against B-cell malignancy and solid tumors in clinical trials. T-cell engineering with tumor-specific chimeric antigen receptors (CARs) is one proven approach that aims to redirect autologous patient T-cells to sites of tumor. This platform has evolved dramatically over the past two decades to include an improved construct design, and these modern CARs have only recently been translated into the clinic for brain tumors. We review here emerging immunotherapeutic platforms for the treatment of MG, focusing on the development and application of a CAR-based strategy against GBM. PMID:25722935

  2. Malignant Catarrhal Fever

    Science.gov (United States)

    Malignant catarrhal fever (MCF) is a frequently fatal viral disease of ruminant species, particularly cattle, bison, and deer. Clinical signs vary between species. Two major epidemiologic types of MCF exist, and are defined by the ruminant species that serve as natural reservoir hosts for infection...

  3. Malignant epithelioma of the liver

    OpenAIRE

    Burroughs, A. K.; Barter, S. J.; Jenkins, W. J.

    1981-01-01

    Carcinoma complicating congenital cystic conditions of the liver is rare. The authors report a primary malignant epithelioma of the liver in association with multiple intrahepatic biliary cysts, which are not usually considered to predispose to malignancy.

  4. JAMA Patient Page: Malignant Hyperthermia

    Science.gov (United States)

    ... of the American Medical Association JAMA PATIENT PAGE Malignant Hyperthermia M alignant hyperthermia ( MH ) is severe, potentially ... energy consumption after exposure to certain anesthetic drugs. Malignant hyperthermia occurs in persons who have a genetic ( ...

  5. Translational advances in pleural malignancies

    OpenAIRE

    Stathopoulos, Georgios

    2010-01-01

    Pleural malignancies, including primary malignant pleural mesothelioma and secondary pleural metastasis of various tumours resulting in malignant pleural effusion, are frequent and lethal diseases that deserve devoted translational research efforts for improvements to be introduced to the clinic. This paper highlights select clinical advances that have been accomplished recently and that are based on preclinical research on pleural malignancies. Examples are the establishment of folate antime...

  6. Malignant Melanoma of the Foot

    Science.gov (United States)

    ... Melanoma of the Foot Text Size Print Bookmark Malignant Melanoma of the Foot What is Malignant Melanoma? Melanoma is a cancer that begins in ... that produce pigmentation (coloration). It is also called malignant melanoma because it spreads to other areas of ...

  7. Retroperitoneal dedifferentiated liposarcoma with osteosarcomatous components: a case report.

    Science.gov (United States)

    Fujii, Taishi; Arai, Takuma; Sakon, Masahiro; Sawano, Shinji; Momose, Yoshitaka; Ishii, Keiko; Miwa, Shiro

    2013-01-01

    We report a rare case of recurrent retroperitoneal dedifferentiated liposarcoma with osteosarcomatous components. An 82-year-old male diagnosed with recurrent retroperitoneal liposarcoma underwent a tumor resection. Histologically, osseous matrix with osteoid and mature hyaline cartilaginous tissues with high cellularity were observed in a fibrous background through most of the tumor, and scattered MDM2- and CDK4-positive atypical hyperchromatic stromal cells were detected surrounding the dedifferentiated areas. Dedifferentiation occurs in up to 10% of well-differentiated liposarcomas, frequently resembling a malignant fibrous histiocytoma-like pleomorphic sarcoma. In contrast, divergent differentiation with osteosarcomatous components is considered to be extremely rare. PMID:23826426

  8. Identification of Autotoxic Compounds in Fibrous Roots of Rehmannia (Rehmannia glutinosa Libosch.)

    OpenAIRE

    Li, Zhen-fang; Yang, Yan-qiu; Xie, Dong-feng; Zhu, Lan-fang; Zhang, Zi-guan; Lin, Wen-xiong

    2012-01-01

    Rehmannia is a medicinal plant in China. Autotoxicity has been reported to be one of the major problems hindering the consecutive monoculture of Rehmannia. However, potential autotoxins produced by the fibrous roots are less known. In this study, the autotoxicity of these fibrous roots was investigated. Four groups of autotoxic compounds from the aqueous extracts of the fibrous roots were isolated and characterized. The ethyl acetate extracts of these water-soluble compounds were further anal...

  9. Pembrolizumab in Treating Patients With Malignant Mesothelioma

    Science.gov (United States)

    2015-03-20

    Biphasic Mesothelioma; Epithelioid Mesothelioma; Peritoneal Malignant Mesothelioma; Pleural Biphasic Mesothelioma; Pleural Epithelioid Mesothelioma; Pleural Malignant Mesothelioma; Pleural Sarcomatoid Mesothelioma; Recurrent Peritoneal Malignant Mesothelioma; Recurrent Pleural Malignant Mesothelioma; Sarcomatoid Mesothelioma

  10. Intrapulmonary solitary fibrous tumors: clinicopathologic and immunohistochemical study of 24 cases.

    Science.gov (United States)

    Rao, Nagarjun; Colby, Thomas V; Falconieri, Giovanni; Cohen, Hector; Moran, Cesar A; Suster, Saul

    2013-02-01

    Solitary fibrous tumor (SFT) is a ubiquitous neoplasm that arises most commonly from the pleura. SFT arising within lung parenchyma (intrapulmonary SFT) has been rarely reported and is therefore not well recognized. We present a clinicopathologic and immunohistochemical study of 24 cases of primary intrapulmonary SFT. Patients' ages ranged from 44 to 83 years (mean, 58 y). None of the patients had evidence or history of a similar tumor elsewhere. Tumor size ranged from 2.3 to 22 cm (mean, 8.5 cm). On the basis of the degree of cytologic atypia, cellularity, mitotic activity, and areas of necrosis, the lesions were divided into low-grade, intermediate-grade, and high-grade histology. Twenty-one tumors showed the conventional features of SFT of low-grade histology (sarcoma admixed with foci of conventional, low-grade SFT. Immunohistochemical staining analyses performed in 13 cases showed positivity of the tumor cells for CD34, bcl-2, and CD99 in the majority of cases tested. Clinical follow-up was available in 18 patients, with long-term follow-up (>5 y) in 6. Fourteen (14/18) patients were alive and well without evidence of disease 1 month to 14 years after initial diagnosis. Three patients died of their tumors after 4, 5, and 7 years; in 2 of them the initial tumor was of low-grade histology, but the recurrence/metastases showed a high-grade histology; the third fatal case showed a tumor with high-grade histology at initial diagnosis. One patient with intermediate-grade histology also had chest wall metastases at 5 years but was subsequently lost to follow-up. The results of our study indicate that although tumors with overtly malignant histologic features can be expected to behave as high-grade sarcomas, tumors with bland-appearing morphologic features at presentation may also follow an aggressive behavior. Adequate excision with close clinical follow-up, thus, appears to be the most prudent course of action for the management of primary intrapulmonary fibrous tumors. PMID:23108019

  11. Malignant external otitis

    International Nuclear Information System (INIS)

    This paper illustrates the value of CT and MR in early diagnosis and spread of malignant external otitis. The authors retrospectively analyzed 15 patients with proved malignant external otitis examined with postcontrast high-resolution CT (15/15) and MR (6/15) (T1- and T2-weighting). Gallium studies were done in 6/15 patients. Early diagnosis was made when CT demonstrated a soft-tissue mass of the external auditory canal associated with scattered zones of cortical bone erosions (13/15). Spread of the disease was better delineated by MR than CT, especially skull base extension (6/15). Temporomandibular joint involvement with extension into parotid or/and masticator spaces 6/15 was as well detected with CT as with MR. If CT remains the first and best procedure for diagnosis, MR - despite its cost - appears a good procedure to depict exact anatomic spread, allowing therapeutic management

  12. Hyaluronan in human malignancies

    International Nuclear Information System (INIS)

    Hyaluronan, a major macropolysaccharide in the extracellular matrix of connective tissues, is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of various human tumors and modulates intracellular signaling pathways, cell proliferation, motility and invasive properties of malignant cells. Experimental and clinicopathological evidence highlights the importance of hyaluronan in tumor growth and metastasis. A high stromal hyaluronan content is associated with poorly differentiated tumors and aggressive clinical behavior in human adenocarcinomas. Instead, the squamous cell carcinomas and malignant melanomas tend to have a reduced hyaluronan content. In addition to the stroma-cancer cell interaction, hyaluronan can influence stromal cell recruitment, tumor angiogenesis and epithelial-mesenchymal transition. Hyaluronan receptors, hyaluronan synthases and hyaluronan degrading enzymes, hyaluronidases, are involved in the modulation of cancer progression, depending on the tumor type. Furthermore, intracellular signaling and angiogenesis are affected by the degradation products of hyaluronan. Hyaluronan has also therapeutic implications since it is involved in multidrug resistance.

  13. Hyaluronan in human malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Sironen, R.K. [Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Department of Pathology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland); Tammi, M.; Tammi, R. [Institute of Biomedicine, Anatomy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Auvinen, P.K. [Department of Oncology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland); Anttila, M. [Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Department of Gynecology and Obstetrics, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland); Kosma, V-M., E-mail: Veli-Matti.Kosma@uef.fi [Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Department of Pathology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland)

    2011-02-15

    Hyaluronan, a major macropolysaccharide in the extracellular matrix of connective tissues, is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of various human tumors and modulates intracellular signaling pathways, cell proliferation, motility and invasive properties of malignant cells. Experimental and clinicopathological evidence highlights the importance of hyaluronan in tumor growth and metastasis. A high stromal hyaluronan content is associated with poorly differentiated tumors and aggressive clinical behavior in human adenocarcinomas. Instead, the squamous cell carcinomas and malignant melanomas tend to have a reduced hyaluronan content. In addition to the stroma-cancer cell interaction, hyaluronan can influence stromal cell recruitment, tumor angiogenesis and epithelial-mesenchymal transition. Hyaluronan receptors, hyaluronan synthases and hyaluronan degrading enzymes, hyaluronidases, are involved in the modulation of cancer progression, depending on the tumor type. Furthermore, intracellular signaling and angiogenesis are affected by the degradation products of hyaluronan. Hyaluronan has also therapeutic implications since it is involved in multidrug resistance.

  14. Epigenetics in the hematologic malignancies.

    Science.gov (United States)

    Fong, Chun Yew; Morison, Jessica; Dawson, Mark A

    2014-12-01

    A wealth of genomic and epigenomic data has identified abnormal regulation of epigenetic processes as a prominent theme in hematologic malignancies. Recurrent somatic alterations in myeloid malignancies of key proteins involved in DNA methylation, post-translational histone modification and chromatin remodeling have highlighted the importance of epigenetic regulation of gene expression in the initiation and maintenance of various malignancies. The rational use of targeted epigenetic therapies requires a thorough understanding of the underlying mechanisms of malignant transformation driven by aberrant epigenetic regulators. In this review we provide an overview of the major protagonists in epigenetic regulation, their aberrant role in myeloid malignancies, prognostic significance and potential for therapeutic targeting. PMID:25472952

  15. Subungual amelanotic malignant melanoma.

    OpenAIRE

    Ozer Arican; Sezai Sasmaz; Coban, Yusuf K.; Harun Ciralik

    2006-01-01

    ABSTRACT We report a 61-year-old, male patient complaining from prolonged lesion on his great toe that has been previously treated surgically. Histopathological examination of toenail specimen revealed the presence of nests of atypical tumor cells that led to the diagnosis of amelanotic malignant melanoma. Four years ago, he was diagnosed as gout due to extreme erythema and edema in the same toe. He has been taken to surgical treatment and chemotherapy and is still undergoing. As this dise...

  16. Microbiome and Malignancy

    OpenAIRE

    Plottel, Claudia S.; Blaser, Martin J.

    2011-01-01

    Current knowledge is insufficient to explain why only a proportion of individuals exposed to environmental carcinogens or carrying a genetic predisposition to cancer develop disease. Clearly, other factors must be important and one such element that has recently received attention is the human microbiome, the residential microbes including Bacteria, Archaea, Eukaryotes, and viruses that colonize humans. Here, we review principles and paradigms of microbiome-related malignancy, as illustrated ...

  17. Malignant intraocular tumors

    International Nuclear Information System (INIS)

    The role of the radiation therapist in the management of malignant intraocular tumors is changing. With more active identification of malignant intraocular tumors, and a better recognization of the manner in which one can deal with problems of radiation sensitivity, radiation techniques of all sorts will be more actively employed in the treatment of these tumors. Special techniques must be selected for appropriate circumstances of management in order to diminish to an absolute minimum the impact upon the lens, the impact upon visual acuity and the impact upon the cornea. Cobalt-60 plaques are being used more commonly in the treatment of melanomas of the choroid, and the role for radiation therapy in the management of retinoblastoma is changing markably to where it may be used as the primary treatment program rather than enucleation. In metastatic disease involving the uveal tract, radiation therapy has assumed the most important role for management. Chemotherapy should be considered as an active adjuvant in the management of not only those individuals with retinoblastoma but also in those identified circumstances where metastases to the uveal tract are being treated. The role for chemotherapy or immunotherapy in malignant melanoma is unclear

  18. Radiotherapy of malignant melanomas

    International Nuclear Information System (INIS)

    A study is made of 46 patients with cutaneous and mucoseous malignant melanoma treated in the Department of Radiotherapy of. A.C. Camargo Hospital - Fundacao Antonio Prudente - Sao Paulo - Brazil, from 1960 to 1973. Radiotherapy was employed as a radical procedure in 9 patients, as a, remissive procedure in 10 and as an adjuvant pre-or post-operative therapeutic in 22 patients. Six patients were submitted to actnic hipophysectomy. One out of the cases submitted to radical radiotherapy showed complete response and six patients partial response. Seven out of the ten cases treated with paliative intention did not show symptomatology after radiotherapy that led them to treatment. Under the ever-existing conflict of the clinical literature and experimentation, it is found that there had not been estabilished a definite concept concerning radiosensibility of malignant melanomas yet. The different response to the radiation-therapy from one case to another makes the local prognostic unsafe. It is concluded that the role of radiotherapy has not been perfectly estabilished in the therapeutic approach of malignant melanoma and that prospective studies are needed to situate radiotherapy in the treatment of this disease. (Author)

  19. Radioimmunotherapy of malignant gliomas

    International Nuclear Information System (INIS)

    Despite all technical advances (intraoperative resection control, fluorescence guided resection, advances in external beam radiation techniques) and new consolidated findings on systemic chemotherapy treatment of malignant gliomas with conventional therapeutic modalities (surgery, radiation therapy and chemotherapy) is still highly unfavourable. Total tumor erradication is impossible due to tumor infiltrations into the normal brain and the limitations given by the limited tolerance of surrounding brain tissue. New treatment strategies, therefore, aim for a more selective destruction of tumor cells. Malignant glioma cells selectively express several antigens or receptors which are not or only to a minor extent present in normal brain tissue. Administration of radiolabelled monoclonal antibodies, especially when given locoregionally, targeting these tumor-specific antigens offers an innovative therapeutic strategy that has recently demonstrated encouraging antitumor effects and acceptable toxicity in many phase I/II clinical trials. This review offers a comprehensive summary of own experiences and results of clinical trials reported in the literature dealing with radioimmunotherapy of malignant glioma and highlights future plans to further develop this therapeutic strategy. (orig.)

  20. Displasia fibrosa de seno maxilar / Fibrous Dysplasia of Maxillary Sinus

    Scientific Electronic Library Online (English)

    Cecilia, Parladé Formell; Yamily, González Cardona; Portelles Massó, Ayelén M; Julio O, Fuentes de la Rosa; Mirian, Vivar Bauzá.

    2015-03-01

    Full Text Available La displasia fibrosa fue descrita por Lichtenstein en 1938, es una enfermedad caracterizada por el reemplazo progresivo de tejido óseo normal por una proliferación de tejido conectivo fibroso, por su forma de presentación se clasifica en monostótica o poliostótica. La forma monostótica, localizada e [...] n la región craneofacial constituye solo el 10 % de los casos, se presenta con mayor frecuencia en el maxilar superior y puede afectar a huesos adyacentes como el cigomático, esfenoides y occipital. La degeneración sarcomatosa puede ocurrir en un 0,5 %. Se presenta el caso de una paciente femenina, de 37 años de edad, operada ocho años antes de displasia fibrosa en el Servicio de Cirugía Máxilofacial del Hospital Vladimir I. Lenin, que luego de su embarazo y parto presenta un aumento de volumen en área malar y maxilar izquierdos, a la que se le realiza biopsia que da como resultado una recidiva. Se le realiza cirugía remodelativa de pared anterior de seno maxilar, a través de una incisión de Weber-Ferguson, con buenos resultados estéticos y funcionales. Abstract in english Fibrous dysplasia was described by Lichtenstein in 1938, is a progressive disease characterized by replacement of normal bone tissue by proliferation of fibrous connective tissue, its presentation is classified in monostotic or polyostotic. The monostotic form, located in the craniofacial region con [...] stitutes only 10 % of cases, it occurs most frequently in the maxilla and adjacent bones can affect as the zygomatic, sphenoid and occipital. The sarcomatous degeneration can occur in 0.5 %. A 37-year-old female patient, who underwent fibrous dysplasia surgery eight years ago at Maxillofacial Surgery Department of Vladimir I. Lenin Hospital, which after the pregnancy and delivery presented a volume increase in malar and left area is presented in this paper, biopsy is performed whose results showed a recurrence. Remodeling surgery was performed of anterior wall of the maxillary sinus through a Weber-Ferguson incision with good cosmetic and functional results.

  1. BMP-2-loaded silica nanotube fibrous meshes for bone generation

    International Nuclear Information System (INIS)

    Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol–gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

  2. BMP-2-loaded silica nanotube fibrous meshes for bone generation

    Science.gov (United States)

    Chen, Song; Shi, Xuetao; Morita, Hiromi; Li, Jie; Ogawa, Nobuhiro; Ikoma, Toshiyuki; Hayakawa, Satoshi; Shirosaki, Yuki; Osaka, Akiyoshi; Hanagata, Nobutaka

    2011-12-01

    Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

  3. Solitary fibrous tumor of the post-styloid parapharyngeal space.

    Science.gov (United States)

    Lee, Ji Eun; Hong, Hyun Sook; Chang, Kee-Hyun; Kim, Hee Kyung; Park, Jisang

    2014-07-01

    Solitary fibrous tumor (SFT) is a well-known tumor composed of spindle cells found most commonly in the pleura. Recently, accounts of their rare occurrence at other sites, including the head and neck area, have been reported. The parapharyngeal space is a rare location even for head and neck SFTs, and thus, could be confused with a variety of other tumors that can originate in this area. Here, we report a case of SFT originating from the post-styloid parapharyngeal space and discuss the possible differential diagnosis on radiographic findings. PMID:25298872

  4. Solitary fibrous tumor of the post-styloid parapharyngeal space

    OpenAIRE

    Lee, Ji Eun; Hong, Hyun Sook; Chang, Kee-hyun; Kim, Hee Kyung; Park, Jisang

    2014-01-01

    Solitary fibrous tumor (SFT) is a well-known tumor composed of spindle cells found most commonly in the pleura. Recently, accounts of their rare occurrence at other sites, including the head and neck area, have been reported. The parapharyngeal space is a rare location even for head and neck SFTs, and thus, could be confused with a variety of other tumors that can originate in this area. Here, we report a case of SFT originating from the post-styloid parapharyngeal space and discuss the possi...

  5. Solitary fibrous tumor of the orbit presenting in pregnancy

    Directory of Open Access Journals (Sweden)

    Das Jayanta

    2009-01-01

    Full Text Available A 32-year-old woman, three months pregnant, reported with the complaint of protrusion of the right eye for six months. She gave history of rapid protrusion of eyeball for the last two months along with the history of double vision for the last one month. Computer tomography (CT scan revealed a well-defined mass lesion in the intraconal space of the right orbit which was excised through a lateral orbitotomy approach. Histological examination and immunohistochemistry revealed a solitary fibrous tumor, which showed a rapid progression in pregnancy.

  6. BMP-2-loaded silica nanotube fibrous meshes for bone generation

    Directory of Open Access Journals (Sweden)

    Song Chen, Xuetao Shi, Hiromi Morita, Jie Li, Nobuhiro Ogawa, Toshiyuki Ikoma, Satoshi Hayakawa, Yuki Shirosaki, Akiyoshi Osaka and Nobutaka Hanagata

    2011-01-01

    Full Text Available Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2 and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol–gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

  7. Pleural solitary fibrous tumor complicated with autoimmune hemolytic anemia.

    Science.gov (United States)

    Takahashi, Hiroshi; Ohkawara, Hiroshi; Ikeda, Kazuhiko; Harada-Shirado, Kayo; Furukawa, Miki; Sukegawa, Masumi; Shichishima-Nakamura, Akiko; Noji, Hideyoshi; Wakamatsu, Saho; Tasaki, Kazuhiro; Suzuki, Hiroyuki; Ogawa, Kazuei; Takeishi, Yasuchika

    2014-01-01

    We herein report a 74-year-old woman who presented with autoimmune hemolytic anemia (AIHA) associated with pleural solitary fibrous tumor (SFT). Her AIHA was initially treated with 1 mg/kg daily of oral prednisolone (PSL) for 2 months, which had a limited effect. However, after surgical tumor resection, the patient showed remarkable improvement of AIHA with normalizations of serum lactate dehydrogenase and bilirubin levels, and we were able to rapidly reduce the PSL dosage. This is the first description of a case of AIHA caused by SFT. PMID:25030571

  8. Solitary fibrous tumor of the liver from development to resection.

    Science.gov (United States)

    Makino, Yuki; Miyazaki, Masanori; Shigekawa, Minoru; Ezaki, Hisao; Sakamori, Ryotaro; Yakushijin, Takayuki; Ohkawa, Kazuyoshi; Kato, Motohiko; Akasaka, Tomofumi; Shinzaki, Shinichiro; Nishida, Tsutomu; Miyake, Yuichiro; Hama, Naoki; Nagano, Hiroaki; Honma, Keiichiro; Morii, Eiichi; Wakasa, Kenichi; Hikita, Hayato; Tatsumi, Tomohide; Iijima, Hideki; Hiramatsu, Naoki; Tsujii, Masahiko; Takehara, Tetsuo

    2015-01-01

    A 55-year-old man was annually followed up for a large hepatic cyst. In 2006, a 20-mm nodule was detected in contact with the cyst that gradually grew thereafter. By 2013, the mass had expanded to 90 mm, and a percutaneous biopsy revealed a solitary fibrous tumor (SFT). Surgical resection was subsequently performed, and the patient has since been doing well for 11 months, without recurrence. SFT of the liver is a rare neoplasm; only 44 cases have been reported to date. This is the first report to describe the long-term progression of hepatic SFT from the time of its development. PMID:25832939

  9. Modeling Ablation of Fibrous Materials from Bulk to Knudsen Regime

    Science.gov (United States)

    Lachaud, Jean; Mansour, Nagi N.

    2008-01-01

    Material-environment interactions are analyzed at microscopic scale to explain the lower than expected density observed by post-flight analysis of the char layer on the Stardust shield. Mass transfer, ablation (oxidation), and surface recession of fibrous material is simulated in 3D using a Monte-Carlo simulation tool. Ablation is found to occur either at the surface or in volume depending on Knudsen and Thiele number values. This study supports the idea of volume ablation followed by possible carbon fiber spallation that may explain post-flight analyses.

  10. Oral potentially malignant disorders: Is malignant transformation predictable and preventable?

    OpenAIRE

    Waal, Isaa?c

    2014-01-01

    Leukoplakia is the most common potentially malignant disorder of the oral mucosa. The prevalence is approximately 1% while the annual malignant transformation ranges from 2% to 3%. At present, there are no reliable clinicopathological or molecular predicting factors of malignant transformation that can be used in an individual patient and such event can not truly be prevented. Furthermore, follow-up programs are of questionable value in this respect. Cessation of smoking habits may result in ...

  11. Coupled continuum and molecular model of flow through fibrous filter

    Science.gov (United States)

    Zhao, Shunliu; Povitsky, Alex

    2013-11-01

    A coupled approach combining the continuum boundary singularity method (BSM) and the molecular direct simulation Monte Carlo (DSMC) is developed and validated using Taylor-Couette flow and the flow about a single fiber confined between two parallel walls. In the proposed approach, the DSMC is applied to an annular region enclosing the fiber and the BSM is employed in the entire flow domain. The parameters used in the DSMC and the coupling procedure, such as the number of simulated particles, the cell size, and the size of the coupling zone are determined by inspecting the accuracy of pressure drop obtained for the range of Knudsen numbers between zero and unity. The developed approach is used to study flowfield of fibrous filtration flows. It is observed that in the partial-slip flow regime, Kn ? 0.25, the results obtained by the proposed coupled BSM-DSMC method match the solution by BSM combined with the heuristic partial-slip boundary conditions. For transition molecular-to-continuum Knudsen numbers, 0.25 modeling of transition low Reynolds number flows in fibrous filters.

  12. A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots

    Directory of Open Access Journals (Sweden)

    Yong Yan Wang

    2011-10-01

    Full Text Available The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus. From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-?-D-glucopyranoside and three known glycosides [1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (liriopeoside A, 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside, and 1?,6?-dihydroxy-5,10-bis-epi-eudesm-4(15-ene-6-O-? D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-?-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC50 value of 339.76 ?g/mL, while liriopeoside A (LC50 = 82.84 ?g/mL and 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (LC50 = 153.39 ?g/mL also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC50 value of 182.56 ?g/mL.

  13. A new eudesmane sesquiterpene glucoside from Liriope muscari fibrous roots.

    Science.gov (United States)

    Zhang, Hai Ming; Wang, Gang Li; Bai, Chun Qi; Liu, Peng; Liu, Zi Mu; Liu, Qi Zhi; Wang, Yong Yan; Liu, Zhi Long; Du, Shu Shan; Deng, Zhi Wei

    2011-01-01

    The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus). From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-?-D-glucopyranoside) and three known glycosides [1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (liriopeoside A), 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside, and 1?,6?-dihydroxy-5,10-bis-epi-eudesm-4(15)-ene-6-O-? D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-?-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC(50 )value of 339.76 ?g/mL, while liriopeoside A (LC(50) = 82.84 ?g/mL) and 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (LC(50) = 153.39 ?g/mL) also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC(50) value of 182.56 ?g/mL. PMID:22031065

  14. Polyostotic fibrous dysplasia in a cynomolgus Macaque (Macaca fascicularis).

    Science.gov (United States)

    Bauer, Cassondra; Dunn, Betty G; Brothman, Arthur R; Dick, Edward J; Christensen, Chris; Voges, Andra; Moore, Charleen M

    2012-04-01

    A 2.3-y-old female cynomolgus macaque (Macaca fascicularis) presented with a broken right tibia and fibula. Radiographs showed multiple cyst-like defects in all long bones. We suspected that both fractures were pathologic because they occurred through these defects. Ultrasonography, MRI, and dual X-ray absorptiometry revealed that the defects were filled with soft tissue. Grossly, the bones were abnormal in shape, and a gelatinous material filled the defects and the surrounding marrow cavity. Histologically, the gelatinous material was composed of fibrin and cartilage; few normal bone cells were seen. Genetic testing revealed extra material on the short arm of chromosome 8 in all tissues examined, but no copy number alterations of likely clinical significance were observed, and no abnormalities were found that were unique to the lesions. In light of the clinical signs and radiographic and pathologic findings, polyostotic fibrous dysplasia was diagnosed. This report represents the first documented case of fibrous dysplasia in a cynomolgus macaque. PMID:22546922

  15. Various technologies for adsorptive separation using novel fibrous adsorbents

    International Nuclear Information System (INIS)

    Regions with naturally occurring resources containing rare metals are unevenly distributed throughout the world. The Kuroshio, or Black Current, transports various rare metals dissolved in seawater. For example, the amounts of vanadium and molybdenum annually transported by the Kuroshio are 300- and 400-fold, respectively, compared to the amounts annually consumed in Japan. The reactors of the Fukushima Daiichi Nuclear Power Plant, which were damaged by the Great East Japan Earthquake, caused a meltdown of nuclear fuel and a subsequent hydrogen explosion. By injecting seawater into the reactors for cooling, hundreds of thousands of tons of sea-water containing radioactive species was produced. It was stored in the nuclear power plant, but some of its was released to the ocean. Radioisotopes, such as cesium-137, iodine-131, and strontium-90, dissolved in seawater pose a great risk to sea life and thus should be removed and safety confined. We have developed a new preparation technology for fibrous adsorbents capable of selectively collecting ionic species of rare metals in seawater. The fibrous absorbents containing functional moieties exhibited a high adsorption rate, high adsorption capacity, and are easy use with seawater. Here, the adsorption performance of the novel adsorptive fiber in braid form for the recovery of rare metals and the removal of radioisotopes has been described. (author)

  16. Congenital uveal malignant melanoma.

    Science.gov (United States)

    Pukrushpan, Parnchat; Tulvatana, Wasee; Pittayapongpat, Rosana

    2014-04-01

    We report the clinical and pathological findings of a rare case of congenital uveal melanoma. A 7-week-old girl presented with history of a black area at the inner corner of her left eye since birth. Examination revealed an enlarged globe with an area of visible uveal pigment nasal to the cornea, an iris mass, and shallow anterior chamber in the left eye. Magnetic resonance imaging revealed an intraocular mass. Enucleation was performed when the girl was 2 months of age. Pathologic examination confirmed a malignant melanoma epithelioid cell type with extraocular extension. She was treated with chemotherapy and subtotal exenteration. PMID:24698625

  17. Fibrous Dysplasia with Aneurysmal Bone Cyst Presenting as Painful Solitary Skull lesion

    OpenAIRE

    Lee, Jung Won; Kim, Jae Hoon; Han, Seung Hoon; Kang, Hee In

    2010-01-01

    We report a rare case of fibrous dysplasia with the development of a secondary aneurysmal bone cyst presenting as solitary tumor of calvarium. Although fibrous dysplasia with aneurysmal bone cyst is rare, it should be taken into account in differential diagnosis of the osteolytic solitary skull lesion.

  18. Fibrous dysplasia associated with intramuscular myxoma(mazabraud's syndrome) : a case report

    International Nuclear Information System (INIS)

    Mazabraud's syndrome, the etiology of which is unknown, is a rare benign disease, characterized by the association of intramuscular myxoma and fibrous dysplasia of bone, usually polyostotic. We describe a case of Mazabraud's syndrome in which with two intramuscular myxomas of the forearm were associated with polyostotic fibrous dysplasia

  19. The misdiagnosis of malignant melanoma.

    Science.gov (United States)

    Grant-Kels, J M; Bason, E T; Grin, C M

    1999-04-01

    Despite the increasing awareness of malignant melanoma over the last 40 years, clinical diagnostic accuracy remains disappointing. Malignant melanoma can masquerade clinically as benign lesions (false negatives), and benign pigmented lesions can clinically simulate malignant melanoma (false positives). Histologic examination of pigmented lesions is therefore important to ensure proper diagnosis and treatment. We review many of the published reports of benign lesions mimicking melanoma and melanoma masquerading as other entities as well as present additional cases of clinical misdiagnoses of melanoma. PMID:10188671

  20. Malignancy in pigmented villonodular synovitis

    International Nuclear Information System (INIS)

    Malignant pigmented villonodular synovitis is an extremely rare and controversial disease. We describe malignant change in pigmented villonodular synovitis of the ankle in a patient with an unusually long clinical history. Symptoms began at age 21, metastatic disease developed at age 85, and the patient died 1 year later. The histologic appearance of the malignant tumor differed from that in most reported cases, in that spindle-shaped cells predominated. Lymph node metastasis also developed, a feature uncommon to soft tissue sarcomas. (orig.)

  1. Ibrutinib for B cell malignancies

    OpenAIRE

    Novero, Aileen; Ravella, Pavan M.; Chen, Yamei; Dous, George; Liu, Delong

    2014-01-01

    Research over the role of Bruton’s agammaglobulinemia tyrosine kinase (BTK) in B-lymphocyte development, differentiation, signaling and survival has led to better understanding of the pathogenesis of B-cell malignancies. Down-regulation of BTK activity is an attractive novel strategy for treating patients with B-cell malignancies. Ibrutinib (PCI-32765), a potent inhibitor of BTK induces impressive responses in B-cell malignancies through irreversible bond with cysteine-481 in the active sit...

  2. Molecular biology of malignant mesothelioma

    OpenAIRE

    Sekido, Yoshitaka

    2008-01-01

    Human malignancies develop via a multi-step that involves the accumulation of several key gene alterations with associated genetic and epigenetic events. Although malignant mesothelioma (MM) has been demonstrated to be clearly correlated with asbestos exposure, it remains poorly understood how asbestos fibers confer key gene alterations and induce cellular transformation in normal mesothelial cells, which results in the acquisition of malignant phenotypes, including deregulated cell prolifera...

  3. An epidemiological and clinical analysis of craniomaxillofacial fibrous dysplasia in a Chinese population

    Directory of Open Access Journals (Sweden)

    Cheng Jie

    2012-10-01

    Full Text Available Abstract Background Craniomaxillofacial fibrous dysplasia (FD is a benign bone lesion characterized by facial disfigurement and functional impairment. The aim of this study was to characterize the epidemiological and clinical features of craniomaxillofacial FD by presenting data from a representative Chinese population during a 15-year period (1994–2009. Method The craniomaxillofacial disease registries of two Chinese tertiary referral hospitals (Shanghai Ninth People’s Hospital and Stomatological hospital of Jiangsu Province were searched and reviewed to collect relevant information for patients with craniomaxillofacial FD between Jan.1994 and Dec.2009. All included cases were further analyzed with regard to associated epidemiological and clinicopathological variables. Results A total number of 266 cases with definitive diagnosis were identified with 219 primary cases and 47 recurrent cases. There were 111 males and 155 females with a male to female ratio of 0.716:1. They were clinically categorized into three groups: monostotic (71.1%, polysotic (27.4% and Albright syndrome (1.5%. Maxilla alone or with adjacent bones was the most common affected site. The serum alkaline phosphatase (ALP in patients was much higher than that in healthy control, whereas comparable between primary patients and recurrent ones. Three patients (3/266, 1.1% with polysotic lesions underwent spontaneous malignant transformation into osteosarcoma. The majority of patients underwent conservative surgery, while the others received radical resection with or without reconstruction. Conclusions Craniomaxillofacial FD is a rare bony disorder with defined epidemiological and clinicopathological features in Chinese population. Further investigations are warranted to establish the optimized timing, treatment strategy and prognostic prediction for this clinical entity.

  4. Use of artificial intelligence techniques for diagnosis of malignant pleural mesothelioma

    Directory of Open Access Journals (Sweden)

    Orhan Er

    2015-03-01

    Full Text Available Objective: Malignant pleural mesothelioma is a highly aggressive tumor of the serous membranes, which in humans results from exposure to asbestos and asbestiform fibers. The incidence of malignant mesothelioma is extremely high in some Turkish villages where there is a low-level environmental exposure to erionite, a fibrous zeolite. Therefore epidemiological studies are difficult to perform in Turkey. Methods: In this paper, a study on malignant pleural mesothelioma disease diagnosis was realized by using artificial immune system. Also, the artificial immune system result was compared with the result of the multi-layer neural network focusing on malignant pleural mesothelioma disease diagnosis and using same database. The malignant pleural mesothelioma disease dataset were prepared from a faculty of medicine’s database using patient’s hospital reports. Results: 97.74% accuracy performance is obtained by artificial immune system. The accuracy results of artificial immune system algorithm are much better than the accuracy results of multi-layer neural network algorithm. Conclusion: This system is capable of conducting the classification process with a good performance to help the expert while deciding the healthy and patient subjects. So, this structure can be helpful as learning based decision support system for contributing to the doctors in their diagnosis decisions.

  5. Malignant glaucoma Glaucoma maligno

    Directory of Open Access Journals (Sweden)

    Sebastião Cronemberger

    2012-10-01

    Full Text Available The aim of this review is to discuss current knowledge about pathophysiology and clinical, therapeutic and prophylactic approaches for malignant glaucoma. This type of glaucoma can occur after different surgical procedures. It can also occur in aphakic, phakic and pseudophakic eyes and develop spontaneously in individuals with no ocular surgical history, or associated with topical miotics. Currently, the ultrasound biomicroscopy has provided many interesting and useful findings for diagnosis and monitoring the treatment of malignant glaucoma. It occurs more often in short eyes in which pre operative measurements of the anterior chamber depth and axial length are extremely important for its prophylaxis and diagnosis.O objetivo deste artigo de revisão é discutir o conhecimento atual sobre a fisiopatologia e as abordagens diagnóstica, terapêutica e profilática do glaucoma maligno. Este tipo de glaucoma pode ocorrer após diferentes procedimentos cirúrgicos. Pode ocorrer em olhos áfacos, fácicos e pseudofácicos e se desenvolver espontaneamente em olhos não-operados, ou associado ao uso de mióticos. Atualmente, a biomicroscopia ultrassônica tem revelado muitos achados úteis e importantes para o diagnóstico e o tratamento do glaucoma maligno. Ele ocorre com maior frequência em olhos pequenos nos quais as medidas pré-operatórias da profundidade da câmara anterior e do comprimento axial são extremamente importantes para a sua profilaxia e diagnóstico.

  6. Malignant glaucoma / Glaucoma maligno

    Scientific Electronic Library Online (English)

    Sebastião, Cronemberger; Nassim, Calixto; Alberto, Diniz Filho.

    2012-10-01

    Full Text Available SciELO Brazil | Language: English Abstract in portuguese O objetivo deste artigo de revisão é discutir o conhecimento atual sobre a fisiopatologia e as abordagens diagnóstica, terapêutica e profilática do glaucoma maligno. Este tipo de glaucoma pode ocorrer após diferentes procedimentos cirúrgicos. Pode ocorrer em olhos áfacos, fácicos e pseudofácicos e s [...] e desenvolver espontaneamente em olhos não-operados, ou associado ao uso de mióticos. Atualmente, a biomicroscopia ultrassônica tem revelado muitos achados úteis e importantes para o diagnóstico e o tratamento do glaucoma maligno. Ele ocorre com maior frequência em olhos pequenos nos quais as medidas pré-operatórias da profundidade da câmara anterior e do comprimento axial são extremamente importantes para a sua profilaxia e diagnóstico. Abstract in english The aim of this review is to discuss current knowledge about pathophysiology and clinical, therapeutic and prophylactic approaches for malignant glaucoma. This type of glaucoma can occur after different surgical procedures. It can also occur in aphakic, phakic and pseudophakic eyes and develop spont [...] aneously in individuals with no ocular surgical history, or associated with topical miotics. Currently, the ultrasound biomicroscopy has provided many interesting and useful findings for diagnosis and monitoring the treatment of malignant glaucoma. It occurs more often in short eyes in which pre operative measurements of the anterior chamber depth and axial length are extremely important for its prophylaxis and diagnosis.

  7. Radiotherapy of malignant melanoma

    International Nuclear Information System (INIS)

    The role of radiotherapy in the treatment of malignant melanoma is limited, and surgery generally forms the mainstay of medical practice. However, there are some circumstances in which radiotherapy should be considered the treatment of choice. Symptomatic metastatic lesions in bone or brain can effectively be palliated in a substantial proportion of instances. At the current stage of our knowledge, conventionally fractionated treatment of such lesions forms the standard against which other treatments should be measured. In contrast, metastatic lesions to skin or lymph nodes that do not overlie critical normal structures probably are better treated by high-dose-per-fraction techniques. Radiotherapy may play a definitive role in the treatment of lentigo maligna. The precise optimal energy of the beam to be used remains to be defined. Slightly more penetrating radiation appears to be required for lentigo maligna melanomas. Here, too, the optimal energy remains to be defined. The treatment of nonlentigenous melanomas primarily by radiotherapy is unproved in my opinion. Certainly, the data from the Princess Margaret Hospital is exciting, but I believe it must be corroborated by a well-designed trial before it can be accepted without question. Future directions in treatment of malignant melanoma are likely to include further trials of unconventional fractionation and the use of radiosensitizing agents in conjunction with radiotherapy. The time for dermatologists and radiatiy. The time for dermatologists and radiation therapists to cooperate in such studies is at hand

  8. Malignant thoracic lymphomas

    International Nuclear Information System (INIS)

    A series of 234 malignant lymphomas (121 Hodgkin lymphomas and 113 non-Hodgkin lymphomas) observed at the Brescia City Hospital between 1981 and 1987 has been reviewed. This paper is aimed at assessing: 1) in which sectors of the staging radiology is indicated, 2)which radiological techniques are needed for the staging of chest lymphomas; 3) which impact they have on the therapeutic program. All patients underwent chest X-ray, which was integrated by conventional Tomography in 80% of cases. Only 76 patients underwent CT: 35 times for staging, and 69 times for restaging (overall figure: 104). The two techniques were compared: - in untreated patiens CT gave supplementary information in 19 out of 35 cases (54.3%). In 7 patients (20%) the findings were such as to determine a change in the previous staging, only in a case (2.8%) was the management affected; - in treated patients CT proved to be superior to conventional radiology in 28 out of 69 cases (40.56%) and allowed the possibility of a recurrence (which was suggested by clinical and radiological findings) to be ruled out in 23 patients (33.3%). In our opinion, CT should not be used as a routine investigation in the staging of malignant thoracic lymphomas; on the contrary, it should be limited to selected cases, when a radical radiotherapy is to be performed, or when clinics and plain radiographs proved unable to assess the nature of a pathologic thoracic condition

  9. Translational advances in pleural malignancies.

    Science.gov (United States)

    Stathopoulos, Georgios T

    2011-01-01

    Pleural malignancies, including primary malignant pleural mesothelioma and secondary pleural metastasis of various tumours resulting in malignant pleural effusion, are frequent and lethal diseases that deserve devoted translational research efforts for improvements to be introduced to the clinic. This paper highlights select clinical advances that have been accomplished recently and that are based on preclinical research on pleural malignancies. Examples are the establishment of folate antimetabolites in mesothelioma treatment, the use of PET in mesothelioma management and the discovery of mesothelin as a marker of mesothelioma. In addition to established translational advances, this text focuses on recent research findings that are anticipated to impact clinical pleural oncology in the near future. Such progress has been substantial, including the development of a genetic mouse model of mesothelioma and of transplantable models of pleural malignancies in immunocompetent hosts, the deployment of stereological and imaging methods for integral assessment of pleural tumour burden, as well as the discovery of the therapeutic potential of aminobiphosphonates, histone deacetylase inhibitors and ribonucleases against malignant pleural disease. Finally, key obstacles to overcome towards a more rapid advancement of translational research in pleural malignancies are outlined. These include the dissection of cell-autonomous and paracrine pathways of pleural tumour progression, the study of mesothelioma and malignant pleural effusion separately from other tumours at both the clinical and preclinical levels, and the expansion of tissue banks and consortia of clinical research of pleural malignancies. PMID:21044230

  10. Malignant sertoli cell tumor in a goose (Anser cygnoides domesticus).

    Science.gov (United States)

    Uetsuka, Koji; Suzuki, Takayuki; Doi, Kunio; Nunoya, Tetsuo

    2012-12-01

    This paper describes the pathologic features of a malignant Sertoli cell tumor found in an adult goose (Anser cygnoides domesticus). At necropsy, in addition to one large tumor mass (15 cm in diameter), multiple small tumor masses were observed over the peritoneum and mesenterium in the coelomic cavity. The large tumor mass was composed of sheets, lobules, and small islands of tumor cells, and elongated tumor cells lying perpendicular to fibrous connective tissue were characteristic. Such histopathologic characteristics were common to all the tumors. The tumor cells were immunohistochemically positive for neuron-specific enolase and S-100, and some tumor cells contained fine intracytoplasmic pigments that stained red by oil red O staining. These findings, taken together with the fact that one testis was markedly atrophied and bore no tumor cells and the other testis was not discernible, the present case was diagnosed as unilateral malignant Sertoli cell tumor arising from the unilateral testis. To our knowledge, this is the first report of Sertoli cell tumor in the goose. PMID:23397858

  11. Axonal regeneration through the fibrous scar in lesioned goldfish spinal cord.

    Science.gov (United States)

    Takeda, A; Atobe, Y; Kadota, T; Goris, R C; Funakoshi, K

    2015-01-22

    Spontaneous nerve regeneration beyond the scar frequently occurs in fish after spinal cord lesions, in contrast to mammals. Here we examined the spatiotemporal relationship between the fibrous scar and axonal regeneration in the goldfish. Within 1 week after hemisection of the spinal cord, the open wound was closed by a fibrous scar that was demarcated from the surrounding nervous tissue by the glia limitans, which was immunoreactive for laminin. Within 1 week after hemisection, regenerating axons entered the fibrous scar, and were surrounded by laminin-coated tubular structures continuous with the glia limitans. Regenerating axons that initially entered the fibrous scar were usually accompanied by glial processes. Within 2-3 weeks after hemisection, the tubular structures became enlarged, and the regenerating axons increased in number, fasciculating in the tubules. Glial processes immunoreactive for glial fibrillary acid protein and 5-hydroxytryptamine neurons then entered the tubular structures to associate with the regenerating axons. The tubular structures developed further, creating tunnels that penetrated the fibrous scar, through which the regenerating axons passed. At 6-12 weeks after hemisection, the fibrous scar was smaller and the enlarged tunnels contained many glial processes and several axons. The findings of present study demonstrated that, following spinal lesions in goldfish, regenerating axons enter and pass the scar tissue. The regenerating axons first enter the fibrous scar with glial elements and then grow through laminin-coated tubular structures within the fibrous scar. Invasion by glial processes and neuronal elements into the tubular structures reduces the fibrous scar area and allows for more regenerating axons to pass beyond the fibrous scar. PMID:25290012

  12. Primary pineal malignant melanoma

    Directory of Open Access Journals (Sweden)

    Cesar La Cruz Pelea

    2011-05-01

    Full Text Available Primary pineal malignant melanoma is a rare entity, with only thirteen cases reported in the world literature to date. We report a case of a 70-year-old man, who consulted with gait disturbance of six months duration, associated in the last month with dizziness, visual abnormalities and diplopia. No other additional melanocytic lesions were found elsewhere. The magnetic resonance showed a 25 mm expansive mass in the pineal gland that was associated with hydrocephaly, ventricular and transependimary oedema. The lesion was partially excised by a supracerebellar infratentorial approach. The histological examination revealed a melanoma. The patient received radiation therapy, but died of disease 16 weeks later. We herein review the literature on this rare tumour and comment on its clinical, radiological and histopathological features and differential diagnosis.

  13. Immunoscintigraphy of malignant melanomas

    International Nuclear Information System (INIS)

    This work is part of a multicentric European evaluation of the monoclonal antibody 225.28s targeted against malignant melanoma and its metastases. Twenty-eight patients (12 males, 16 females, mean age: 53 yrs), who had initially been treated by resection of the primary tumour, were included in the study. Twenty-three of the 26 metastases more than 1 cm in diameter were visualized by immunoscintigraphy. The sensitivity of the procedure (88%) is limited however by the small size of the lesions and their depth, as well as by background noise caused by circulating antibodies. Immunoscintigraphy enables non-invasive investigation of the whole body and can detect lesions that other conventional complementary explorations fail to identify

  14. CT findings of retroperitoneal masses

    International Nuclear Information System (INIS)

    Retrospective analysis of forty one retroperitoneal masses was made with computed tomography. All cases were confirmed pathologically by operation or needle aspiration biopsy. The cases were; 14 abscesses, 2 leiomyosarcomas, 2 rhabdomyosarcomas, 2 liposarcomas, 1 undifferentiated sarcoma, 3 endodermal sinus tumors, 4 teratomas, 2 neurofibromas, 1 neurilemoma, 3 neuroblastomas, 4 malignant lymphomas, 2 malignant fibrous histiocytomas and 1 hemangiopericytoma. Tumors originated from urinary tract and pancreas were not included. Findings favor tumor rather than inflammation were; large lobulated soft tissue mass with eccentric or heterogeneous low density, thick cavity wall, disruption of fascial planes, regional lymphnode enlargement and distant metastasis

  15. CT findings of retroperitoneal masses

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sung Moon; Huh, Jin Do; Kim, Ho Joon; Joh, Young Duk; Chun, Byung Hee [Kosin Medical College, Busan (Korea, Republic of); Woo, Seong Ku; Suh, Soo Jhi [School of Medicine, Keimyung University, Daegu (Korea, Republic of)

    1987-10-15

    Retrospective analysis of forty one retroperitoneal masses was made with computed tomography. All cases were confirmed pathologically by operation or needle aspiration biopsy. The cases were; 14 abscesses, 2 leiomyosarcomas, 2 rhabdomyosarcomas, 2 liposarcomas, 1 undifferentiated sarcoma, 3 endodermal sinus tumors, 4 teratomas, 2 neurofibromas, 1 neurilemoma, 3 neuroblastomas, 4 malignant lymphomas, 2 malignant fibrous histiocytomas and 1 hemangiopericytoma. Tumors originated from urinary tract and pancreas were not included. Findings favor tumor rather than inflammation were; large lobulated soft tissue mass with eccentric or heterogeneous low density, thick cavity wall, disruption of fascial planes, regional lymphnode enlargement and distant metastasis.

  16. A case of dedifferentiated liposarcoma showing a biphasic pattern on 2-deoxy-2-F18- fluoro-D-glucose positron emission tomography/ computed tomography

    Directory of Open Access Journals (Sweden)

    Kenichi Wakasa

    2013-04-01

    Full Text Available Integrated 2-deoxy-2-F18-fluoro-D-glucose positron emission tomography combined with computed tomography (FDG-PET/CT has been used in the field of soft tissue sarcoma. We report an 81-year-old man with dedifferentiated liposarcoma in the left thigh, which was composed of well-differentiated liposarcoma and pleomorphic malignant fibrous histiocytoma. As well as other radiological modalities, FDG-PET was able to demonstrate a biphasic signal pattern composed of well-differentiated liposarcoma and dedifferentiated area, being consistent with the histological grade of malignancy.

  17. A case of dedifferentiated liposarcoma showing a biphasic pattern on 2-deoxy-2-f(18)-fluoro-d-glucose positron emission tomography/computed tomography.

    Science.gov (United States)

    Hoshi, Manabu; Oebisu, Naoto; Takada, Jun; Wakasa, Kenichi; Nakamura, Hiroaki

    2013-04-15

    Integrated 2-deoxy-2-F(18)-fluoro-D-glucose positron emission tomography combined with computed tomography (FDG-PET/CT) has been used in the field of soft tissue sarcoma. We report an 81-year-old man with dedifferentiated liposarcoma in the left thigh, which was composed of well-differentiated liposarcoma and pleomorphic malignant fibrous histiocytoma. As well as other radiological modalities, FDG-PET was able to demonstrate a biphasic signal pattern composed of well-differentiated liposarcoma and dedifferentiated area, being consistent with the histological grade of malignancy. PMID:23888226

  18. {sup 99m}Tc-HMDP accumulation in soft tissue tumor

    Energy Technology Data Exchange (ETDEWEB)

    Momose, Mitsuhiro [Shinshu Univ., Matsumoto, Nagano (Japan). School of Medicine

    2000-11-01

    Accumulation with bone scintigraphy using technetium-99m hydroxymethylene diphosphonate ({sup 99m}Tc-HMDP) in 68 cases with radiographically or pathologically verified soft tissue tumor was examined. Radiographical or histopathologic diagnoses of the 68 cases included; 14 lipomas, 11 liposarcomas, 11 neurinomas or neurofibromas, 6 malignant lymphomas, 5 malignant fibrous histiocytomas, 5 hemangioma, rhabdomyosarcomas, 2 Langerhans cell histiocytoses, 2 desmoid tumors and one each of neuroblastoma, hemangiopericytoma, angiomyxoma, plasmacytoma, liomyosarcoma, lymphangioma, fibrosarcoma, elastofibroma, synovial sarcoma, and ganglion. Thirty-seven (54%) showed positive accumulation and 31 were negative. One half of soft tissue tumors can be accumulated by {sup 99m}Tc-HMDP. (author)

  19. Gliosarcoma with liposarcomatous differentiation: the new member of the lipid-containing brain tumors family.

    Science.gov (United States)

    Vlodavsky, Eugene; Konstantinesku, Marius; Soustiel, Jean F

    2006-03-01

    Gliosarcoma is a rare malignant, biphasic brain tumor composed of glioblastoma multiforme and sarcomatous components. Various types of sarcomatous differentiation are described in this tumor: fibrosarcomatous, malignant fibrous histiocytoma-like, chondrosarcomatous and osteosarcomatous types. We report an extremely unusual variant of liposarcomatous differentiation in gliosarcoma in 72-year-old woman. Fat cells were presented by atypical multivacuolar and monovacuolar lipoblasts, stained positive for S100. p53 that was positive in both glial and mesenchymal cells of the tumor were negative in the lipoblasts. To the best of our knowledge, this is the first report in the literature of liposarcomatous differentiation in gliosarcoma. PMID:16519569

  20. Helminths and malignancy

    DEFF Research Database (Denmark)

    Vennervald, Birgitte J; Polman, K.

    2009-01-01

    It has been estimated that chronic infections with viruses, bacteria and parasites contribute to 17.8% of the global burden of cancer, although only a relatively small proportion of the infection-related cancers can be attributed to helminth infections. These are important because of the high number of people who are exposed or infected worldwide. Carcinogenesis associated with helminth infections is a complex process, which may involve several different mechanisms, but chronic inflammation is a key feature. Host immune responses and immunopathological processes mediate inflammatory responses and any failure in the control of the immunological components involved in this response can lead to chronic inflammation. This may generate a microenvironment that might be conducive to the initiation and development of cancer. Inflammatory cells generate free radicals and nitrogen species, which can oxidize and damage DNA and lead to genetic instabilities and malignant transformation. Physical damage caused by the parasites, their eggs or secreted products leads to restorative hyperplasia of the damaged tissue. This may promote the propagation of cells, in which genotoxic damage and pre-malignant change has taken place. Three helminth infections have been classified as definitely carcinogenic to humans (group 1 carcinogens), namely Schistosoma haematobium, which is associated with cancer of the urinary bladder and the food-borne liver flukes Clonorchis sinensis and Opisthorchis viverrini associated with cholangiocarcinoma of the liver. Reducing the level of infection and the risk of getting (re)infected will reduce the risk of cancer development later in life. Helminth infections are thus a preventable cause of cancer, emphasizing the need for sustainable helminth control in endemic areas coupled with health education, especially in relation to food-borne liver fluke infections.

  1. Malignant hyperthermia in children

    Directory of Open Access Journals (Sweden)

    Igrutinovi? Zoran

    2008-01-01

    Full Text Available INTRODUCTION Malignant hyperthermia is a rare disease which is mainly an inherited autosomal dominant trait. It is characteristic for muscle rigidity, metabolism or respiratory acidosis, high values of serum creatine kinase. Then appears myoglobinuria which can lead to tubular necrosis and acute renal failure. CASE OUTLINE The male child, ten years old, hospitalized because of the high temperature, exhaustion and cough. On the second day of hospitalization, he has hyperthermia (39.8°C, dyspnoea, tachypnoea, was somnolent, occasionally raving, exhausted with the pains in the muscles which were rigid and painfully sensitive. During the night, the urine was dark red, but the diuresis was well. The next day, laboratory analyses showed high values of aspartate aminotransferase (4263 IU/l, alanine aminotransferase (1311 IU/l, lactate dehydrogenase (11787 IU/l, while the values of serum creatine kinase were so high that they could not be registered. The urine analysis showed the negative result on gall colours and haematuria and positive on myoglobin. During the following days, the patient had normal skin temperature, the pains in the muscles were gradually weakened and the urine cleared up. On the third day, the value of creatine kinase was measured and it was 178700 IU/l. During the next two weeks, the clinical finding was gradually normalized while the laboratory values of serum enzyme were gradually normalized only in twenty days. CONCLUSION Malignant hyperthermia is a serious clinical syndrome which can be found with, until then, a clinically healthy child (without chronic myopathy and it appears with the high temperature or during the surgical interventions with anesthetics, which is especially dangerous.

  2. Primary intracranial malignant lymphoma

    International Nuclear Information System (INIS)

    Nine cases of primary intracranial malignant lymphoma, which accounts for 3.3 % of all intracranial tumors seen in the authors' institution, were studied in terms of diagnostic computed tomographic (CT) features, the tumors' histologic appearance, treatment, post-treatment blood immunologic and cerebrospinal fluid (CSF) characteristics, and outcome. The patients were seven males and two females aged 42 to 67 years. Their chief signs and symptoms on admission were intracranial hypertension, focal signs, and disturbance of consciousness. CT, which proved the most useful preoperative diagnostic technique, demonstrated multiple lesions in seven cases and, in all cases, regions of isodensity or slight high density that were enhanced by contrast medium. According to the patterns of enhancement, the tumors were classed as diffuse (three cases) or nodular (six cases). The former is considered typical of malignant lymphoma, whereas the latter type was sometimes indistinguishable from metastatic tumor and meningioma. At surgery, one patient underwent radical tumor excision, two partial removal, and six biopsy only. Histologic examination revealed one tumor to be of the diffuse small cell type, three of the medium cell type, and five of the large cell type (Lymphoma Study Group classification). Of seven tumors in which lymphocytes were examined by peroxidase-antiperoxidase staining, four were of the B cell type. Postoperatively, whole brain irradiation with 29 to 46 Gy was folloain irradiation with 29 to 46 Gy was followed by local irradiation with 15 to 50 Gy. If the tumor persisted, one of three chemotherapies was administered. In one case, methotrexate was given intrathecally. Seven patients were divided into two groups: long remission (three) and recurrence (four). These two groups were compared in terms of serum immunoglobulin levels, T and B cell ratios, CSF characteristics, CT features, tumor cell type, and treatment. No clear differences were found. (author)

  3. Lower gastrointestinal malignancies

    International Nuclear Information System (INIS)

    Objective: This refresher course will review the current knowledge as well as ongoing and future research strategies in lower gastrointestinal malignancies. Radiation therapy has a significant role in the adjuvant treatment of lower gastrointestinal malignancies. Furthermore, there are data to suggest that radiation therapy is an integral component of the conservative management (organ preservation) of rectal and anal cancers. 1. Colon cancer. The standard adjuvant treatment for node positive or high risk transmural colon cancer is postoperative 5-FU and Levamisole. There are retrospective data to suggest that certain subsets of high risk patients may benefit from postoperative radiation therapy. 2. Rectal cancer. Randomized trials have revealed an advantage of postoperative radiation therapy plus chemotherapy in transmural and/or node positive rectal cancer. In the adjuvant setting the use of continuous infusion 5-FU may be more beneficial compared with bolus 5-FU. Despite the improvement in survival, postoperative therapies are associated with an approximately 35% incidence of grade 3+ toxicity. Recent data suggest that the use of preoperative combined modality therapy may be associated with less toxicity as well as increase the chance of sphincter preservation. New Intergroup trials addressing these issues will be presented. In patients with locally advanced unresectable rectal cancer, the addition of intraoperative radiation therapy may further improve local contron therapy may further improve local control. 3. Anal cancer. The use of combined 5-FU/Mitomycin-C and pelvic radiation therapy is effective in the treatment of anal carcinoma. The RTOG has recently completed a randomized trial addressing the question of the effectiveness and toxicity of Mitomycin-C. The replacement Intergroup Phase III trial will be presented

  4. Malignant degeneration of benign neurofibroma.

    Science.gov (United States)

    Leon, P; Prigoff, M M; Smith, A R; Humble, F N

    1992-01-01

    Neurofibromas in the lower extremity are very uncommon, and malignant degeneration of these lesions is extremely rare. The authors present this case involving a malignant schwannoma (neurofibroma) located proximal to the tarsal tunnel with attachments to the Achilles tendon. The diagnosis was made after extensive pathologic evaluation. PMID:1645004

  5. Malignant priapism: a case report.

    LENUS (Irish Health Repository)

    Ellanti, P

    2011-12-01

    Metastatic involvement of the penis is most commonly from a primary malignant genitourinary tumour. It is a rare phenomenon usually reflecting disseminated malignancy associated with a poor prognosis. Metastasis to the penis mimicking priapism is extremely rare, particularly in the absence of disseminated disease.

  6. A theoretical analysis of local thermal equilibrium in fibrous materials

    Directory of Open Access Journals (Sweden)

    Tian Mingwei

    2015-01-01

    Full Text Available The internal heat exchange between each phase and the Local Thermal Equilibrium (LTE scenarios in multi-phase fibrous materials are considered in this paper. Based on the two-phase heat transfer model, a criterion is proposed to evaluate the LTE condition, using derived characteristic parameters. Furthermore, the LTE situations in isothermal/adiabatic boundary cases with two different heat sources (constant heat flux and constant temperature are assessed as special transient cases to test the proposed criterion system, and the influence of such different cases on their LTE status are elucidated. In addition, it is demonstrated that even the convective boundary problems can be generally estimated using this approach. Finally, effects on LTE of the material properties (thermal conductivity, volumetric heat capacity of each phase, sample porosity and pore hydraulic radius are investigated, illustrated and discussed in our study.

  7. Effect of microaerobic fermentation in preprocessing fibrous lignocellulosic materials.

    Science.gov (United States)

    Alattar, Manar Arica; Green, Terrence R; Henry, Jordan; Gulca, Vitalie; Tizazu, Mikias; Bergstrom, Robby; Popa, Radu

    2012-06-01

    Amending soil with organic matter is common in agricultural and logging practices. Such amendments have benefits to soil fertility and crop yields. These benefits may be increased if material is preprocessed before introduction into soil. We analyzed the efficiency of microaerobic fermentation (MF), also referred to as Bokashi, in preprocessing fibrous lignocellulosic (FLC) organic materials using varying produce amendments and leachate treatments. Adding produce amendments increased leachate production and fermentation rates and decreased the biological oxygen demand of the leachate. Continuously draining leachate without returning it to the fermentors led to acidification and decreased concentrations of polysaccharides (PS) in leachates. PS fragmentation and the production of soluble metabolites and gases stabilized in fermentors in about 2-4 weeks. About 2 % of the carbon content was lost as CO(2). PS degradation rates, upon introduction of processed materials into soil, were similar to unfermented FLC. Our results indicate that MF is insufficient for adequate preprocessing of FLC material. PMID:22639359

  8. Determination of physical properties of fibrous thermal insulation

    Directory of Open Access Journals (Sweden)

    Jeandel G.

    2012-10-01

    Full Text Available The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a device developed in house. The radiative properties of the material are determined by an inverse method based on measurements of transmittance and reflectance using a FTIR spectrometer and by solving the equation of radiative heat transfer. These measures are compared to results of numerical simulations.

  9. Fibrous tumor of the superior oblique tendon in Proteus syndrome.

    Science.gov (United States)

    Trivedi, Dipti; Lee, Samuel Y S; Brundler, Marie-Anne; Parulekar, Manoj V

    2013-08-01

    Proteus syndrome is a disorder of patchy, or mosaic, postnatal overgrowth. Mosaic somatic mutation of the AKT1 gene has been identified in over 90% of individuals meeting the diagnostic criteria for Proteus syndrome. Onset occurs in infancy and can involve any tissue of the body. The connective tissue and bone, skin, central nervous system, and the eye are commonly involved. Epibulbar tumors, strabismus, and posterior segment involvement have previously been reported. However, there have not been any reports of lesions affecting the extraocular tendons. We report a case of Proteus syndrome patient presenting with vertical strabismus secondary to a fibrous tumor within the superior oblique tendon. The tumor was successfully excised with complete resolution of the strabismus. PMID:23896365

  10. Hyperostotic esthesioneuroblasma: Rare variant and fibrous dysplasia mimicker

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, Manzoor [Neuroradiology Section, Imaging Institute, Cleveland Clinic Foundation, Cleveland (United States); Knott, Phillip Daniel [Director of Facial Plastic and Reconstructive Surgery, Associate Professor of Otolaryngology, UCSF School of Medicine, San Fransisco (United States)

    2014-02-15

    A 65-year-old male presented with a 3-year history of orbital symptoms. An imaging-based diagnosis of fibrous dysplasia involving the skull base was made at another institution. CT showed a diffuse sinonasal mass and ground-glass appearance of the bones of the anterior skull base with bony defects and mucocele formation. MRI demonstrated an accompanying intracranial and orbital rind of soft tissue mass along the hyperostotic bones. FDG-PET showed corresponding intense hypermetabolism. Small cysts were observed at the tumor-brain interface. Biopsy revealed esthesioneuroblastoma with bone infiltration that is compatible with the hyperostotic variant of esthesioneuroblastoma. There are a few cases of hyperostotic esthesioneuroblastoma reported in the literature.

  11. Hybridized boron-carbon nitride fibrous nanostructures on Ni substrates

    International Nuclear Information System (INIS)

    Stoichiometric BC2N films can be deposited on Si (100) at 800 deg. C, however, they are phase separated as pure carbon and BN phases. Likewise, hybridized boron-carbon nitride (BCN) films can be synthesized on Ni substrates. On Ni, the carbon and BN phases are hybridized through carbon nitride and boron carbide bonds. These films appeared as fibrous nanostructures. Evidence indicates that the Ni substrate acts as a sink for the carbon and forces the carbon composites to grow on top of the B and N atoms. However, as these films are grown thicker, phase separation occurs again. These results indicate that hybridized BCN phases should now be regarded as semiconducting or superhard nanostructures. High-temperature deposition on Ni substrates might be a solution to the obstacle of preparing hybridized BCN phases

  12. Scaling behaviour in the fracture of fibrous materials

    CERN Document Server

    Menezes-Sobrinho, I L; Bernardes, A T

    2000-01-01

    We study the existence of distinct failure regimes in a model for fracture in fibrous materials. We simulate a bundle of parallel fibers under uniaxial static load and observe two different failure regimes: a catastrophic and a slowly shredding. In the catastrophic regime the initial deformation produces a crack which percolates through the bundle. In the slowly shredding regime the initial deformations will produce small cracks which gradually weaken the bundle. The boundary between the catastrophic and the shredding regimes is studied by means of percolation theory and of finite-size scaling theory. In this boundary, the percolation density $\\rho$ scales with the system size $L$, which implies the existence of a second-order phase transition with the same critical exponents as those of usual percolation.

  13. Roughness exponent in the fracture of fibrous materials

    CERN Document Server

    Menezes-Sobrinho, I L

    2001-01-01

    In this letter, a computational model in (2+1)-dimensions which simulates the rupture process of a fibrous material submitted to a constant force $F$, is analyzed. The roughness exponent $\\zeta$ at the boundary that separates two failure regimes, catastrophic and slowly shredding, is evaluated. In the catastrophic regime the initial strain creates a crack which percolates rapidly through the material. In the slowly shredding regime several cracks of small size appear in all parts of the material, the rupture process is slow and any single crack percolates the sample. At the boundary between these two regimes, we obtained a value $\\zeta\\simeq 0.42\\pm 0.02$ for the roughness exponent, in agreement with results provided by other simulations in three dimension. Also, at this boundary we observed a power law behavior on the number of cracks {\\it versus} its size.

  14. Configuration of Fibrous and Adipose Tissues in the Cavernous Sinus

    Science.gov (United States)

    Liang, Liang; Gao, Fei; Xu, Qunyuan; Zhang, Ming

    2014-01-01

    Objective Three-dimensional anatomical appreciation of the matrix of the cavernous sinus is one of the crucial necessities for a better understanding of tissue patterning and various disorders in the sinus. The purpose of this study was to reveal configuration of fibrous and adipose components in the cavernous sinus and their relationship with the cranial nerves and vessels in the sinus and meningeal sinus wall. Materials and Methods Nineteen cadavers (8 females and 11 males; age range, 54–89 years; mean age, 75 years) were prepared as transverse (6 sets), coronal (3 sets) and sagittal (10 sets) plastinated sections that were examined at both macroscopic and microscopic levels. Results Two types of the web-like fibrous networks were identified and localized in the cavernous sinus. A dural trabecular network constituted a skeleton-frame in the sinus and contributed to the sleeves of intracavernous cranial nerves III, IV, V1, V2 and VI. A fine trabecular network, or adipose tissue, was the matrix of the sinus and was mainly distributed along the medial side of the intracavernous cranial nerves, forming a dumbbell-shaped adipose zone in the sinus. Conclusions This study revealed the nature, fine architecture and localization of the fine and dural trabecular networks in the cavernous sinus and their relationship with intracavernous cranial nerves and vessels. The results may be valuable for better understanding of tissue patterning in the cranial base and better evaluation of intracavernous disorders, e.g. the growth direction and extent of intracavernous tumors. PMID:24586578

  15. Malignant peripheral nerve sheath tumors.

    Science.gov (United States)

    Gupta, Gaurav; Maniker, Allen

    2007-01-01

    Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue sarcomas of ectomesenchymal origin. The World Health Organization coined the term MPNST to replace previous heterogeneous and often confusing terminology, such as "malignant schwannoma," "malignant neurilemmoma," "neurogenic sarcoma," and "neurofibrosarcoma." Malignant peripheral nerve sheath tumors arise from major or minor peripheral nerve branches or sheaths of peripheral nerve fibers, and are derived from Schwann cells or pluripotent cells of neural crest origin. The Schwann cell is thought to be the major contributor to the formation of benign as well as malignant neoplasms of the nerve sheath. While this fact remains essentially true, the identity of cell of origin of the MPNST remains elusive, and has not yet been conclusively identified. It has been suggested that these tumors may have multiple cell line origins. In this review, the authors discuss the epidemiology, diagnosis, management, and treatment of MPNSTs. PMID:17613203

  16. Radiographic Differential Diagnosis Between The Fibrous Dysplasia And The Ossifying Fibroma

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Karp Shik [Dept. of Dental Radiology, College of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    1999-02-15

    The author observed and compared the radiographic features of 49 cases of the fibrous dysplasia and 14 cases of the ossifying fibroma in the osteoblastic or mature stage radiologically and histopathologically. The obtained results were as follows: 1. Fibrous dysplasia occurred most frequently in the 2nd decade, but ossifying fibroma in the 3rd and 4th decades, and both lesions occurred with slight predilection in females. 2. In most cases, chief complaints were painless facial swelling. And 61.1% of fibrous dysplasia occurred in the maxilla, 92.9% of ossifying fibroma in the mandible, and most of these lesions occurred in the premolar-molar region. 3. In the mandibular lesions, ossifying fibroma was shown more oval and round shape, but fibrous dysplasia was shown fusiform shape. 4. Fibrous dysplasia was shown homogeneously distributed, complete radiopaque shadow at 63%, and ossifying fibroma was shown concentric, mixed appearance of radiolucent and radiopaque shadow at 92.9%. 5. Fibrous dysplasia was entirely shown poorly outlined and blended to normal surrounding bone, but ossifying fibroma was shown well-defined border. 6. Cortical thinning and expansion were observed in these lesions, but degree of cortical expansion was more severe in ossifying fibroma than fibrous dysplasia. 7. Loss of lamina dura, tooth displacement, and displacement of mandibular canal were observed in both lesions, but root resorption was observed in ossifying fibroma only.

  17. Radiographic Differential Diagnosis Between The Fibrous Dysplasia And The Ossifying Fibroma

    International Nuclear Information System (INIS)

    The author observed and compared the radiographic features of 49 cases of the fibrous dysplasia and 14 cases of the ossifying fibroma in the osteoblastic or mature stage radiologically and histopathologically. The obtained results were as follows: 1. Fibrous dysplasia occurred most frequently in the 2nd decade, but ossifying fibroma in the 3rd and 4th decades, and both lesions occurred with slight predilection in females. 2. In most cases, chief complaints were painless facial swelling. And 61.1% of fibrous dysplasia occurred in the maxilla, 92.9% of ossifying fibroma in the mandible, and most of these lesions occurred in the premolar-molar region. 3. In the mandibular lesions, ossifying fibroma was shown more oval and round shape, but fibrous dysplasia was shown fusiform shape. 4. Fibrous dysplasia was shown homogeneously distributed, complete radiopaque shadow at 63%, and ossifying fibroma was shown concentric, mixed appearance of radiolucent and radiopaque shadow at 92.9%. 5. Fibrous dysplasia was entirely shown poorly outlined and blended to normal surrounding bone, but ossifying fibroma was shown well-defined border. 6. Cortical thinning and expansion were observed in these lesions, but degree of cortical expansion was more severe in ossifying fibroma than fibrous dysplasia. 7. Loss of lamina dura, tooth displacement, and displacement of mandibular canal were observed in both lesions, but root resorption was observed in ossifying fibroma only.ssifying fibroma only.

  18. A study on heat transfer characteristics of spherical and fibrous alumina nanofluids

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chang Kyu [Nuclear Materials Research Division, Korea Atomic Energy Research Institute, Daeduk-daero 989-111, Dukjin-dong, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Quantum Energy Chemical Engineering, University of Science and Technology, 176 Gajung-dong, 217 Gajungro, Yuseong-gu, Daejeon 305-350 (Korea, Republic of); Lee, Gyoung-Ja [Nuclear Materials Research Division, Korea Atomic Energy Research Institute, Daeduk-daero 989-111, Dukjin-dong, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Rhee, Chang Kyu, E-mail: ckrhee@kaeri.re.kr [Nuclear Materials Research Division, Korea Atomic Energy Research Institute, Daeduk-daero 989-111, Dukjin-dong, Yuseong-gu, Daejeon 305-353 (Korea, Republic of)

    2012-08-20

    Highlights: Black-Right-Pointing-Pointer Spherical and fibrous alumina nanoparticles were prepared by pulsed wire evaporation and hydrolysis methods. Black-Right-Pointing-Pointer Fibrous alumina nanofluid exhibited higher thermal conductivity enhancement than spherical one due to entangled structure of nanofibers with high aspect-ratio. Black-Right-Pointing-Pointer Decreasing rate of viscosity with temperature for fibrous alumina nanofluid was much larger than that for spherical one. - Abstract: Ethylene glycol based nanofluids containing spherical/fibrous alumina nanoparticles were synthesized by pulsed wire evaporation and hydrolysis methods. The crystallographic and morphological properties of the prepared nanoparticles were analyzed by X-ray diffraction, nitrogen gas adsorption and transmission electron microscopy. The average diameter of spherical alumina nanoparticles was about 80 nm and the alumina nanofibers exhibited a high aspect ratio (length/width). The viscosity and thermal conductivity of the spherical/fibrous alumina nanofluids were experimentally measured in the temperature range from 25 to 80 Degree-Sign C. For the fibrous alumina nanofluid, the increase of temperature raised thermal conductivity but lowered viscosity. On the other hand, for the spherical alumina nanofluid, both thermal conductivity and viscosity were decreased with increasing temperature. In particular, the fibrous alumina nanofluid exhibited a higher enhancement of thermal conductivity than the spherical one due to the well-connected structure between entangled nanofibers with high aspect ratio.

  19. Isolation and characterization of human and rabbit sperm tail fibrous sheath.

    Science.gov (United States)

    Kim, Y H; de Kretser, D M; Temple-Smith, P D; Hearn, M T; McFarlane, J R

    1997-04-01

    Using mechanical and chemical dissection methods, fibrous sheath was isolated both from normal ejaculated human spermatozoa and from rabbit cauda epididymal spermatozoa. The same techniques did not produce a pure preparation of fibrous sheath from ejaculated rabbit spermatozoa, suggesting that further cross-linking and stabilization of sperm structures occurs in response to components of the seminal plasma. The isolation procedures were monitored by phase contrast microscopy and the purity of the fibrous sheath was verified by electron microscopy. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) of isolated human fibrous sheath revealed at least 14 protein bands of which the most intensely stained were of molecular weight 84, 72, 66.2, 57, 32 and 28.5 kDa. The rabbit fibrous sheath revealed at least 10 protein bands, of which the most intensely stained were 35.2, 32.7 and 28.5 kDa. The amino acid composition of the purified fibrous sheath from human and rabbit spermatozoa was similar, being high in aspartic acid and/or asparagine and glutamic acid and/or glutamine, serine, alanine, leucine, lysine and glycine, but low in histidine, tyrosine and isoleucine. This composition is similar to that reported for the rat and suggests that mammalian sperm tail fibrous sheaths are composed of similar types of proteins, although there are apparent differences in protein components between species. PMID:9237258

  20. Polyostotic fibrous dysplasia associated with intramuscular myxomas: Mazabraud's syndrome

    International Nuclear Information System (INIS)

    Mazabraud's syndrome, though uncommon, is reported increasingly frequently. It represents an entity readily recognisable radiologically on MR imaging. Awareness of the syndrome, particularly when the myxoma is solitary, can prevent misdiagnosis of intramuscular myxomas (especially when large) as malignant mesenchymal tumors containing myxoid tissue. We review the 34 cases previously reported in the literature and include a recent case from our center. (orig.)

  1. A large infiltrating fibrous hamartoma of infancy in the abdominal wall with rare associated tuberous sclerosis

    International Nuclear Information System (INIS)

    Tuberous sclerosis is a complex autosomal-dominant neurocutaneous syndrome characterized by hamartomatous malformations of fibrous and connective tissues in various organs. Although various histologic types of soft-tissue masses can occur with tuberous sclerosis, we present a unique case of fibrous hamartoma of infancy presenting as large infiltrating cutaneous and subcutaneous masses in the abdominal wall in a 4-year-old boy with tuberous sclerosis. Although the co-occurrence of tuberous sclerosis and fibrous hamartoma of infancy is very rare, it should be considered in the differential diagnosis of subcutaneous soft-tissue masses found in children with tuberous sclerosis. (orig.)

  2. Effect of Fibrous Concrete Layers on Behavior of Self-Compacting Concrete Slabs under Uniform Load

    OpenAIRE

    Al-ridha, Dr Ahmed S. D.

    2014-01-01

    This research study the effect of using fibrous concrete layers on behavior of two way Self-Compacting Concrete slabs with ratio (length/width) ?1.618 [golden ratio] using steel fiber. The experimental work can be divided in two groups, each group having steel fiber–volume fractions of 0.4% and 0.8%, moreover both groups having two concrete slabs one with two fibrous layers (bottom + top) and the other with one fibrous layer (bottom), in additional to concrete slab without...

  3. Case report 557: Solitary intramuscular myxoma in a patient with polyostotic fibrous dysplacia

    International Nuclear Information System (INIS)

    We report a case of solitary intramuscular myxoma in a patient with polyostotic fibrous dysplasia and pigmented macules. MR played an important role in the patient's pre-operative evaluation. It has been demonstrated in a review of the literature that a definite relationship exists between myxoma of soft tissues and fibrous dysplasia of the skeleton. Multiple myxomas in a patient with fibrous dysplasia are common and a relationship also exists between myxoma of the soft tissues and the McCune-Albright syndrome. (orig./GDG)

  4. Clostridium septicum infection and malignancy.

    Science.gov (United States)

    Katlic, M R; Derkac, W M; Coleman, W S

    1981-03-01

    Evidence mounts favoring the relationship, albeit unexplained, between Clostridium septicum infection and malignancy, particularly hematologic or intestinal malignancy. Seven patients with C. septicum gangrene or sepsis have been treated at the Massachusetts General Hospital in the years 1977-79. All of these patients have had associated malignant disease: four patients had colon adenocarcinomas, two patients had acute myeloblastic leukemias, and one patient had breast carcinoma. In six of the seven patients, the malignancy was in an advanced state; the breast carcinoma showed no evidence of recurrence after mastectomy, 17 years earlier. A bowel portal of entry is postulated in five patients. Despite prompt use of appropriate antibiotics, the only survivors were two of the four patients who underwent early extensive debridement. These results suggest that, in the patient with C. septicum infection, malignancy should be sought; that, in the septic patient with known malignancy, C. septicum should be considered; and that, in the absence of external source in the patient with clostridial myonecrosis or sepsis, the cecum or distal ileum should be considered a likely site of infection. Increased awareness of this association between C. septicum and malignancy, and aggressive surgical treatment, may result in improvement in the present 50-70% mortality rate. PMID:7212798

  5. Infectious pathogens and hematologic malignancy.

    Science.gov (United States)

    Sadrzadeh, Hossein; Abtahi, Seyed M; Fathi, Amir T

    2012-12-01

    Infectious pathogens have been linked to the genesis of malignancy in a variety of different settings. Initial studies in virology led to the important discovery of key genetic alterations underlying common malignancies, and further, lent support to the notion that malignancy can be promoted by the process of viral infection and cellular transformation. In this review, we summarize a series of hematologic malignancies with derivations from and associations with infectious organisms. Among these are a variety of lymphomas, including Hodgkin's lymphoma (Hodgkin's disease), Burkitt lymphoma, and a host of other non-Hodgkin's lymphomas. Through innovative and ground-breaking studies, some of these malignancies have been directly linked to viral infection, such as the Epstein-Barr virus (EBV), while others have been merely associated with infection through epidemiologic studies and case-reports. Some malignancies have been demonstrated to be caused by viral infection, such as adult T-cell leukemia and lymphoma (ATLL), which is caused by the human T cell lymphotropic virus type I (HTLV-I), in certain endemic area. In the future, additional malignant states may be found to be associated with infectious etiology, which could allow for novel approaches to prevention and treatment. PMID:23272694

  6. Pathogenesis of malignant mesothelioma.

    Science.gov (United States)

    Carbone, Michele; Rdzanek, Monica A

    2004-04-01

    Malignant mesothelioma (MM) is a very aggressive tumor that is caused by environmental, biologic, and genetic factors. Among these factors, asbestos plays a major role. The link between asbestos and MM has been firmly established through numerous epidemiologic studies conducted during the past 40 years. However, the causal role of chrysotile asbestos compared with crocidolite asbestos in MM, the method of correctly establishing asbestos exposure, the amount of asbestos necessary to cause MM, and the mechanisms of asbestos tumorigenicity are still being debated. Along with asbestos, Simian virus 40 (SV40), a DNA monkey virus, has recently been implicated in the etiology of MM. Simian virus 40 large T antigen (Tag) and small t antigen (tag) are largely responsible for the carcinogenicity of the virus, and it is possible that SV40 and asbestos are cocarcinogens. Finally, a genetic factor identified in 3 villages in Cappadocia, Turkey, where 50% of individuals die of MM, appears to be the cause of a high incidence of the disease. In these villages, genetic predisposition for MM works together with erionite, a nonasbestos fiber found in the stones used in construction of houses. The diagnosis of MM is made histologically and confirmed through electron microscopy and immunohistochemistry. Currently available therapies for MM prolong survival by a few months at most. An SV40 vaccine is being developed for human use and it is hoped that it may reduce the incidence of MM in asbestos workers. PMID:15117424

  7. Second primary malignancies after treatment for malignant lymphoma

    OpenAIRE

    Okines, A.; Thomson, C. S.; Radstone, C. R.; Horsman, J. M.; Hancock, B. W.

    2005-01-01

    To determine the incidence and possible causes of second primary malignancies after treatment for Hodgkin's and Non-Hodgkin's lymphoma (HL and NHL). A cohort of 3764 consecutive patients diagnosed with HL or NHL between January 1970 and July 2001 was identified using the Sheffield Lymphoma Group database. A search was undertaken for all patients diagnosed with a subsequent primary malignancy. Two matched controls were identified for each case. Odds ratios were calculated to detect and quantif...

  8. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Rigali

    2001-10-01

    Published mechanical and thermal properties data on a variety of materials was gathered, with focus on materials that have potential with respect to developing wear resistant and damage tolerant composite for mining industry applications. Preliminary core materials of interest include but are not limited to: Diamond, Tungsten Carbide and Cemented Tungsten Carbides, Carbides of Boron, Silicon, Titanium and Aluminum, Diboride of Titanium and Aluminum, Nitrides of Aluminum, Silicon, Titanium, and Boron, Aluminum Oxide, Tungsten, Titanium, Iron, Cobalt and Metal Alloys. Preliminary boundary materials of interest include but are not limited to: W metal, WC-Co, W-Co, WFeNi, and Mo metal and alloys. Several FM test coupons were fabricated with various compositions using the above listed materials. These coupons were consolidated to varying degrees by uniaxial hot pressing, then cut and ground to expose the FM cell structure. One promising system, WC-Co core and WFeNi boundary, was consolidated to 97% of theoretical density, and demonstrates excellent hardness. Data on standard mechanical tests was gathered, and tests will begin on the consolidated test coupons during the upcoming reporting period. The program statements of work for ACR Inc. and its subcontractors, as well as the final contract negotiations, were finalized during the current reporting period. The program start date was February 22nd, 2001. In addition to the current subcontractors, Kennametal Inc., a major manufacturer of cutting tools and wear resistant tooling for the mining industry, expressed considerable interest in ACR's Fibrous Monolith composites for both machine and mining applications. At the request of Kennametal, ARC Inc fabricated and delivered several Fibrous Monolith coupons and components for testing and evaluation in the mining and machine tool applications. Additional samples of Diamond/Tungsten Carbide-6%Cobalt Fibrous Monolith were fabricated and delivered for testing Kennametal's Rapid Omni-directional Consolidation (ROC) Process. A meeting was held with Kennametal Inc. September 27th, 2001. At this meeting, Kennametal expressed interest in working with ACR on three mining tool applications including roof bits, point attack tooling and drill bit inserts. In addition, there is considerable interest in developing FM composite machine cutting tools, which involves crosscutting technology. In addition to the discussions on business development, Kennametal reported on testing performed on ACR's FM composites the first quarter of this year. ACR Inc. also visited Tribocor Inc. of Houston TX to discuss the possibility of teaming to consolidate diamond/WC-Co composite coatings. Diamond-based composites require special high pressure consolidation equipment and Tribocor has expressed an interest in providing diamond powder preparation and consolidation services, to enable the mass-production of a low cost diamond-based FM composite products including drill bit inserts and point attack tools. Tribocor has agreed to perform consolidation of diamond/WC-Co FM coated inserts to verify their consolidation process and produce test pieces that we can press into mining drill bits for field testing.

  9. Characterization of gamma-ray induced graftcopolymers of fibrous cotton cellulose-acrylamide system

    International Nuclear Information System (INIS)

    Graftcopolymers of fibrous cotton cellulose prepared by both pre-irradiation and simultaneous irradiation technique using Co-60 radiation source, have been investigated for the characterization of grafting. (author)

  10. Case report 207: Giant cell reparative granuloma of left femur arising in polyostatic fibrous dysplasia

    International Nuclear Information System (INIS)

    Diagnosis and differential diagnosis of lytic lesions in the femur are discussed. Roentgenograms, a tomogram and pathological studies of a giant cell reparative granuloma of left femur arising in polyostotic fibrous dysplasia are presented. (WU)

  11. Assessment of fibrous insulation materials for the selenide isotope generator system

    International Nuclear Information System (INIS)

    Fibrous insulations for use in the converter and the heat source of the radioisotope-powered, selenide element, thermoelectric generator (selenide isotope generator) are assessed. The most recent system design and material selection basis is presented. Several fibrous insulation materials which have the potential for use as load-bearing or nonload-bearing thermal insulations are reviewed, and thermophysical properties supplied by manufacturers or published in the literature are presented. Potential problems with the application of fibrous insulations in the selenide isotope generator are as follows: compatibility with graphite, the thermoelectric elements, and the isolation hot frame; devitrification, grain growth, and sintering with an accompanying degradation of insulation quality; impurity diffusion from the insulation to adjoining structures; outgassing and storage of fibrous materials. Areas in which thermophysical data or quantitative information on the insulation and structural stability is lacking are identified

  12. Assessment of fibrous insulation materials for the selenide isotope generator system

    Energy Technology Data Exchange (ETDEWEB)

    Wei, G.C; Tennery, V.J.

    1977-11-01

    Fibrous insulations for use in the converter and the heat source of the radioisotope-powered, selenide element, thermoelectric generator (selenide isotope generator) are assessed. The most recent system design and material selection basis is presented. Several fibrous insulation materials which have the potential for use as load-bearing or nonload-bearing thermal insulations are reviewed, and thermophysical properties supplied by manufacturers or published in the literature are presented. Potential problems with the application of fibrous insulations in the selenide isotope generator are as follows: compatibility with graphite, the thermoelectric elements, and the isolation hot frame; devitrification, grain growth, and sintering with an accompanying degradation of insulation quality; impurity diffusion from the insulation to adjoining structures; outgassing and storage of fibrous materials. Areas in which thermophysical data or quantitative information on the insulation and structural stability is lacking are identified.

  13. Malignant TOXication of T cells.

    Science.gov (United States)

    Odum, Niels

    2015-02-26

    In this issue of Blood, Huang et al show that aberrant expression of TOX plays a central role in malignant survival, proliferation, and tumor formation in cutaneous T-cell lymphoma (CTCL). PMID:25721042

  14. Measurement of fibrous cap thickness in atherosclerotic plaques by spatiotemporal analysis of laser speckle images

    OpenAIRE

    Nadkarni, Seemantini K.; Bilenca, Alberto; Bouma, Brett E.; Tearney, Guillermo J.

    2006-01-01

    Necrotic-core fibroatheromas (NCFA) with thin, mechanically weak fibrous caps overlying lipid cores comprise the majority of plaques that rupture and cause acute myocardial infarction. Laser speckle imaging (LSI) has been recently demonstrated to enable atherosclerotic plaque characterization with high accuracy. We investigate spatio-temporal analysis of LSI data, in conjunction with diffusion theory and Monte Carlo modeling of light transport, to estimate fibrous cap thickness in NCFAs. Time...

  15. Liquid perfluorochemical-supported hybrid cell culture system for proliferation of chondrocytes on fibrous polylactide scaffolds

    OpenAIRE

    Pilarek, Maciej; Grabowska, Iwona; Senderek, Ilona; Wojasin?ski, Micha?; Janicka, Justyna; Janczyk-ilach, Katarzyna; Ciach, Tomasz

    2014-01-01

    CP5 bovine chondrocytes were cultured on biodegradable electrospun fibrous polylactide (PLA) scaffolds placed on a flexible interface formed between two immiscible liquid phases: (1) hydrophobic perfluorochemical (PFC) and (2) aqueous culture medium, as a new way of cartilage implant development. Robust and intensive growth of CP5 cells was achieved in our hybrid liquid–solid–liquid culture system consisting of the fibrous PLA scaffolds in contrast to limited growth of the CP5 cells in tr...

  16. Cystic solitary fibrous tumor arising from the left occipital meninges: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Bae Geun; Hwang, Yoon Joon; Cha, Soon Joo; Hur, Gham; Kim, Yong Hoon; Kim, Su Young; Seo, Jung Wook; Lee, Ji Young; Kim, Han Seung [Ilsan Paik Hospital, Inje University, School of Medicine, Goyang (Korea, Republic of)

    2007-02-15

    Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm of a spindle-cell origin, and it usually involves the pleura. It's occurrence in various organs of the body has recently been described. Meningeal SFT is very rare. Radiologically, it is a strongly enhancing solid mass and is undistinguishable from fibrous meningioma and hemangiopericytoma. Yet we report here on a case of SFT with massive cystic degeneration that arose from the meninges of the left occipital region.

  17. Fat-forming variant of solitary fibrous tumour of the pleura: CT findings

    OpenAIRE

    Park, C. Y.; Rho, J. Y.; Yoo, S. M.; Jung, H. K.

    2011-01-01

    The fat-forming variant of solitary fibrous tumour (SFT) was previously called lipomatous haemangiopericytoma and is a rare variant of solitary fibrous tumour. It predominantly occurs in the deep soft tissues of the retroperitoneum and thigh. Only a handful of cases involving the perineum, spine, thoracic wall and pelvic cavity have been reported in the radiological literature and the fat-forming variant of SFT involving the pleura has not been previously reported. Herein, we report the CT fi...

  18. Microwave ablation of hepatic malignancy.

    Science.gov (United States)

    Lubner, Meghan G; Brace, Christopher L; Ziemlewicz, Tim J; Hinshaw, J Louis; Lee, Fred T

    2013-03-01

    Microwave ablation is an extremely promising heat-based thermal ablation modality that has particular applicability in treating hepatic malignancies. Microwaves can generate very high temperatures in very short time periods, potentially leading to improved treatment efficiency and larger ablation zones. As the available technology continues to improve, microwave ablation is emerging as a valuable alternative to radiofrequency ablation in the treatment of hepatic malignancies. This article reviews the current state of microwave ablation including technical and clinical considerations. PMID:24436518

  19. Microwave Ablation of Hepatic Malignancy

    OpenAIRE

    Lubner, Meghan G.; Brace, Christopher L.; Ziemlewicz, Tim J.; Hinshaw, J. Louis; Lee, Fred T.

    2013-01-01

    Microwave ablation is an extremely promising heat-based thermal ablation modality that has particular applicability in treating hepatic malignancies. Microwaves can generate very high temperatures in very short time periods, potentially leading to improved treatment efficiency and larger ablation zones. As the available technology continues to improve, microwave ablation is emerging as a valuable alternative to radiofrequency ablation in the treatment of hepatic malignancies. This article rev...

  20. Oral contraceptives and malignant melanoma.

    OpenAIRE

    Hannaford, P. C.; Villard-mackintosh, L.; Vessey, M. P.; Kay, C. R.

    1991-01-01

    Several studies have suggested that prolonged use of oral contraceptives may increase a woman's risk of developing malignant melanoma. In the Royal College of General Practitioners' Oral Contraception Study, 31 cases of malignant melanoma (code 172--International Classification of Diseases, 8th Revision) have been reported among ever-users and 27 cases among never-users. The risk ratio (RR) (indirectly standardised for age, parity, social class and smoking) was 0.92 (95% confidence interval (...

  1. Optimization of Grafted Fibrous Polymer as a Solid Basic Catalyst for Biodiesel Fuel Production

    Directory of Open Access Journals (Sweden)

    Yuji Ueki

    2014-05-01

    Full Text Available Grafted fibrous polymer with quaternary amine groups could function as a highly-efficient catalyst for biodiesel fuel (BDF production. In this study, the optimization of grafted fibrous polymer (catalyst and transesterification conditions for the effective BDF production was attempted through a batch-wise transesterification of triglyceride (TG with ethanol (EtOH in the presence of a cosolvent. Trimethylamine was the optimal quaternary amine group for the grafted fibrous catalyst. The optimal degree of grafting of the grafted fibrous catalyst was greater than 170%. The optimal transesterification conditions were as follows: The optimal molar quantity of quaternary amine groups, transesterification temperature, molar ratio of TG and EtOH, and primary alkyl alcohol were 0.8 mmol, 80°C, 1:200, and 1-pentanol, respectively. The grafted fibrous catalyst could be applied to BDF production using natural oils. Furthermore, the grafted fibrous catalyst could be used repeatedly after regeneration involving three sequential processes, i.e., organic acid, alkali, and alcohol treatments, without any significant loss of catalytic activity.

  2. Rapid reconstruction of 3D structure of fibrous media

    CERN Document Server

    Berejnov, Viatcheslav; Djilali, Ned

    2009-01-01

    Characterization of transport properties of porous media is increasingly relying on computational methods that require reconstruction of the media structure. We present a simple method of constructing the 3D surface of fibrous porous media - the gas diffusion layer (GDL) used as the porous electrode in PEM fuel cells. The method is based on extending the depth-of-field on the whole attainable thickness of the GDL. A series of images of the GDL sample is recorded by the sequential movement of the sample with respect to the microscope focus. Different layers of the surface of the sample appear in focus in the different images in the series. The indexed series of the in-focus portions of the sample surface is combined into one sharp 2D image and interpolated into the 3D surface representing the surface of an original GDL sample. The method uses a conventional upright stage microscope that is operated manually, the inexpensive Helicon Focus software, and the open source MeshLab software. The accuracy of the recon...

  3. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Rigali; Mike L. Fulcher; Kenneth L. Knittel

    2002-10-01

    During the reporting period, work continued on development of formulations using the materials down-selected from the initially identified contenders for the fibrous monolith wear resistant components. The FM systems studied were: WC-Co/WC-Co, WC-Co/Co, diamond/WC-Co, and Al{sub 2}O{sub 3}/Al{sub 2}O{sub 3}-TiCN. Extrudable formulations for the materials listed were developed during the first twelve months of this effort, and work during the reporting period was focused on the development of optimized binder removal processes. A two stage binder removal process was developed that resulted in prototype parts free of voids and other internal defects. In addition, changes in the binder removal atmosphere resulted in the apparent elimination of residual carbon, an important consideration when consolidating WC-Co containing systems. Using the improved binder removal processes, parts were consolidated by both sintering and hot pressing to >99% theoretical density. Samples of these materials were sent to Kyocera for mechanical evaluations. Fabrication of drill bit inserts was begun, and binder removal begun during the reporting period. A total of 24 green inserts were fabricated, and will be consolidated and delivered for field testing during the upcoming reporting period.

  4. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Rigali; Kenneth L. Knittel; Mike L. Fulcher

    2002-03-01

    During this reporting period, work continued on development of formulations using the materials identified as contenders for the fibrous monolith wear resistant components. The FM structures fabricated were: diamond/WC-Co, B{sub 4}C/WC-Co, TiB{sub 2}/WC-Co, WC-Co/Co, WC-Co/WC-Co. Results of our consolidation densification studies on these systems lead to the down-selection of WC-Co/WC-Co, WC-Co/Co and diamond/WC-Co for further development for mining applications including drill bit inserts, roof bit inserts, radial tools conical tools and wear plates (WC-Co based system only) for earth moving equipment. Prototype component fabrication focused on the fabrication of WC-Co/WC-Co FM conical tools, diamond/WC-Co coated drill bit insert prototypes. Fabrication of WC-Co/WC-Co FM insert prototypes for a grader blade is also underway. ACR plans to initiate field-testing of the drill bit insert prototypes and the grader blade insert this summer (2002). The first WC-Co/WC-Co FM conical tool prototypes were sent to Kennametal for evaluation towards the end of the current reporting period.

  5. Sperm protein 17 is expressed in the sperm fibrous sheath

    Directory of Open Access Journals (Sweden)

    Albani Elena

    2009-07-01

    Full Text Available Abstract Background Sperm protein 17 (Sp17 is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues. It was also recognized in two myeloma cell lines and in neoplastic cells from patients with multiple myeloma and ovarian carcinoma. These data all indicate that Sp17 is widely distributed in humans, expressed not only in germinal cells and in a variety of somatic tissues, but also in neoplastic cells of unrelated origin. Methods Sp17 expression was analyzed by immunocytochemistry and transmission electron microscopy on spermatozoa. Results Here, we demonstrate the ultrastructural localization of human Sp17 throughout the spermatozoa flagellar fibrous sheath, and its presence in spermatozoa during in vitro states from their ejaculation to the oocyte fertilization. Conclusion These findings suggest a possible role of Sp17 in regulating sperm maturation, capacitation, acrosomal reaction and interactions with the oocyte zona pellucida during the fertilization process. Further, the high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP-binding motif within this region, suggest that Sp17 might play a regulatory role in a protein kinase A-independent AKAP complex in both germinal and somatic cells.

  6. Effective property of multiferroic fibrous composites with imperfect interfaces

    International Nuclear Information System (INIS)

    This paper studies the effective behavior of piezoelectric and piezomagnetic circular fibrous composites with imperfect interfaces under longitudinal shear with in-plane electromagnetic fields. Two kinds of imperfect contact are investigated: mechanically stiff and dielectrically/magnetically highly conducting interfaces, and mechanically compliant and dielectrically/magnetically weakly conducting interfaces. For the former case, the potential field is continuous, while the normal component of the flux undergoes a discontinuity across the interface. For the latter case, the normal component of the flux is continuous, while there is a jump of potential field at such a contact. The classic work of Rayleigh (1892 Phil. Mag. 34 481–502) in a periodic conductive perfect composite is generalized to the current coupled magnetoelectroelastic composites with imperfect interfaces. It is shown that the expression of the effective property has exactly the same form as that in the ideal coupling composite. Finally, this method is used to study BaTiO3–CoFe2O4 composites and provide insights into enhancing the effective magnetoelectric voltage coefficient by properly choosing the interface. (paper)

  7. Nanoscale dynamics and aging of fibrous peptide-based gels

    Energy Technology Data Exchange (ETDEWEB)

    Dudukovic, Nikola A., E-mail: dudukov1@illinois.edu [Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States); Zukoski, Charles F. [Department of Chemical and Biological Engineering, University at Buffalo, Buffalo, New York 14222 (United States)

    2014-10-28

    Solutions of the aromatic dipeptide derivative molecule fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) in dimethyl sulfoxide produce fibrous gels when mixed with water. We study the evolution of density fluctuations of this three-component system using X-ray photon correlation spectroscopy (XPCS) and compare these results to the macroscopic rheology of the gels and optical observations of the microstructure evolution. At the investigated scattering angles, the intensity autocorrelation functions do not follow behavior expected for simple diffusion of individual Fmoc-FF molecules localized within cages of nearest neighbors. Instead, the dynamics are associated with density fluctuations on length scales of ?10–100 nm arising from disaggregation and reformation of fibers, leading to an increasingly uniform network. This process is correlated with the growth of the elastic modulus, which saturates at long times. Autocorrelation functions and relaxation times acquired from XPCS measurements are consistent with relaxation rates of structures at dynamic equilibrium. This study provides further support to the concept of exploring peptide-based gelators as valence-limited patchy particles capable of forming equilibrium gels.

  8. Applications of fibrous substrates containing insolubilized phase change polymers

    Science.gov (United States)

    Vigo, Tyrone L.; Bruno, Joseph S.

    1993-01-01

    Incorporation of polyethylene glycols into fibrous substrates produces several improved functional properties when they are insolubilized by crosslinking with a methylolamide resin or by polyacetal formation by their reaction with glyoxal. The range of molecular weights of polyols that may be insolubilized is broad as are the curing conditions (0.25-10 min at 80-200C). Most representative fiber types and blends (natural and synthetic) and all types of fabric constructions (woven, nonwoven and knit) have been modified by incorporation of the bound polyols. The most novel property is the thermal adaptability of the modified substrates to many climatic conditions. This adaptability is due to the high latent heat of the crosslinked polyols that function as phase change materials, the hydrophilic nature of the crosslinked polymer and its enhanced thermal conductivity. Other enhanced properties imparted to fabrics include flex and flat abrasion, antimicrobial activity, reduced static charge, resistance to oily soils, resiliency, wind resistance and reduced lint loss. Applications commercialized in the U.S. and Japan include sportswear and skiwear. Several examples of electric sets of properties useful for specific end uses are given. In addition, other uses are biomedical horticultural, aerospace, indoor insulation, automotive interiors and components and packaging material.

  9. Nanoscale dynamics and aging of fibrous peptide-based gels.

    Science.gov (United States)

    Dudukovic, Nikola A; Zukoski, Charles F

    2014-10-28

    Solutions of the aromatic dipeptide derivative molecule fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) in dimethyl sulfoxide produce fibrous gels when mixed with water. We study the evolution of density fluctuations of this three-component system using X-ray photon correlation spectroscopy (XPCS) and compare these results to the macroscopic rheology of the gels and optical observations of the microstructure evolution. At the investigated scattering angles, the intensity autocorrelation functions do not follow behavior expected for simple diffusion of individual Fmoc-FF molecules localized within cages of nearest neighbors. Instead, the dynamics are associated with density fluctuations on length scales of ~10-100 nm arising from disaggregation and reformation of fibers, leading to an increasingly uniform network. This process is correlated with the growth of the elastic modulus, which saturates at long times. Autocorrelation functions and relaxation times acquired from XPCS measurements are consistent with relaxation rates of structures at dynamic equilibrium. This study provides further support to the concept of exploring peptide-based gelators as valence-limited patchy particles capable of forming equilibrium gels. PMID:25362339

  10. Nanoscale dynamics and aging of fibrous peptide-based gels

    International Nuclear Information System (INIS)

    Solutions of the aromatic dipeptide derivative molecule fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) in dimethyl sulfoxide produce fibrous gels when mixed with water. We study the evolution of density fluctuations of this three-component system using X-ray photon correlation spectroscopy (XPCS) and compare these results to the macroscopic rheology of the gels and optical observations of the microstructure evolution. At the investigated scattering angles, the intensity autocorrelation functions do not follow behavior expected for simple diffusion of individual Fmoc-FF molecules localized within cages of nearest neighbors. Instead, the dynamics are associated with density fluctuations on length scales of ?10–100 nm arising from disaggregation and reformation of fibers, leading to an increasingly uniform network. This process is correlated with the growth of the elastic modulus, which saturates at long times. Autocorrelation functions and relaxation times acquired from XPCS measurements are consistent with relaxation rates of structures at dynamic equilibrium. This study provides further support to the concept of exploring peptide-based gelators as valence-limited patchy particles capable of forming equilibrium gels

  11. Electrospinning growth factor releasing microspheres into fibrous scaffolds.

    Science.gov (United States)

    Whitehead, Tonya J; Sundararaghavan, Harini G

    2014-01-01

    This procedure describes a method to fabricate a multifaceted substrate to direct nerve cell growth. This system incorporates mechanical, topographical, adhesive and chemical signals. Mechanical properties are controlled by the type of material used to fabricate the electrospun fibers. In this protocol we use 30% methacrylated Hyaluronic Acid (HA), which has a tensile modulus of ~500 Pa, to produce a soft fibrous scaffold. Electrospinning on to a rotating mandrel produces aligned fibers to create a topographical cue. Adhesion is achieved by coating the scaffold with fibronectin. The primary challenge addressed herein is providing a chemical signal throughout the depth of the scaffold for extended periods. This procedure describes fabricating poly(lactic-co-glycolic acid) (PLGA) microspheres that contain Nerve Growth Factor (NGF) and directly impregnating the scaffold with these microspheres during the electrospinning process. Due to the harsh production environment, including high sheer forces and electrical charges, protein viability is measured after production. The system provides protein release for over 60 days and has been shown to promote primary nerve cell growth. PMID:25178038

  12. Cutaneous malignant lymphomas: update 2006.

    Science.gov (United States)

    Burg, Günter; Kempf, Werner; Cozzio, Antonio; Döbbeling, Udo; Feit, Josef; Golling, Philippa; Michaelis, Sonja; Schärer, Leo; Nestle, Frank; Dummer, Reinhard

    2006-11-01

    Cutaneous lymphomas represent a unique group of lymphomas and are the second most frequent extranodal lymphomas. As with other neoplasias, the pathogenesis is based mainly on a stepwise accumulation of mutations of suppressor genes and oncogenes caused by genetic, environmental or infectious factors. The diagnostic work-up includes clinical, histological, imaging and hematological investigations and in many cases immunohistochemical and molecular biological analyses. The current WHO/EORTC classification of cutaneous lymphomas differentiates "mature T-cell and NK-cell lymphomas", "mature B-cell lymphomas" and "immature hematopoietic malignancies", their variants and subgroups. It is compatible with the WHO classification for neoplasias of the hematopoietic and lymphoid tissue and respects the organ-specific peculiarities of primary cutaneous lymphomas. The assignment of the various types of cutaneous lymphomas into prognostic categories (pre-lymphomatous "abortive" disorders; definite malignant lymphomas of low-grade malignancy; definite malignant lymphomas of high-grade malignancy) provides essential information on the biological behavior and allows an appropriate planning of the therapeutic strategy, which may be topical or systemic and aggressive or non-aggressive. Besides the classical options for therapy, there are new and "experimental" strategies, the efficacy of which has to be studied in clinical trials. PMID:17081267

  13. Diffusion-creep modelling of fibrous pressure-shadows

    Science.gov (United States)

    Berton, J. R.; Durney, D. W.; Wheeler, J.; Ford, J. M.

    2006-10-01

    Grain-scale deformation of a bimineralic composite by normal-stress-driven grain-boundary diffusive mass-transfer has been modelled using diffusion-creep software that, for the first time, allows different diffusion coefficients for interphase boundaries and grain-boundaries as well as for different components. By selecting suitable coefficients we have obtained a fully coupled mechanical and mass-transfer numerical solution for the formation of fibrous pressure-shadows or strain fringes at the interface between a rigid object and a deforming rock matrix of different compositions. The model is two-dimensional and run in pure-shear velocity mode to a stretch ratio of 1.4. The first results are reported, which show dissolution and face-controlled antitaxial growth of a soluble, polycrystalline, calcite matrix at the interface with a circular and relatively insoluble pyrite object. The ratio of CaCO 3 diffusion along calcite-pyrite versus calcite-calcite boundaries strongly influences the extent of pressure-shadow growth and the pattern of strains in the matrix. A low ratio produces little growth, significant perturbation, and deflection of total-strain axes around the pyrite. An intermediate ratio produces appreciable growth, little perturbation, and near-parallel total-strain axes. A high ratio produces larger pressure-shadows, and total-strain axes that bend in towards the pyrite as if it were a weak object. Sliding and rotation of matrix grains are also affected. These results differ fundamentally from purely physical models of ductile flow around a rigid object and demonstrate the influence of interface diffusional properties on the resulting behaviour. In particular, assumptions such as perturbation of the flow by the object, deflection of external foliation around pre-deformational porphyroblasts and relationships of pressure-shadow strain to bulk strain may need to be re-examined in the light of this finding.

  14. Applications of phase change polymers in fibrous substrates

    International Nuclear Information System (INIS)

    This paper reports on insolubilization of polyethylene glycols (Mn of 600-20,000) onto a variety of fibrous substrates by reaction with a methylolamide resin (DMDHEU or dimethyloldihydroxyethyleneurea) in the presence of acid catalysts produced modified materials that have several improved functional properties and that are useful for numerous applications. Crosslinking or insolubilization of the polyols occurs under mild cuing conditions (80-100 degrees C). The resultant properties of the modified substrate (essentially a flexible composite of fiber and crosslinked polyol in the matrix) are markedly dependent on the proper choice of curing conditions (time and temperature). Representative fiber types and blends that have been modified by this process include: cotton, polyester, polyamide, cotton blends, wool blends, aramids, glass, acrylic, polypropylene, elastomeric fibers and short fibers used to make paper. All types of fabric constructions have been used (woven, nonwoven, and knit). The most novel property is the thermal adaptability of the modified fabrics or substrates to a variety of climatic conditions. This adaptability is due to the high enthalpy of fusion (cooling effect in hot weather) and crystallization (liberation of heat in cold weather) of the crosslinked polyethylene glycols (insolubilized phase change materials or PCM's). The novel thermal effects are due to the hydrophilic nature of the crosslinked polyol as well as its reduced thermal ked polyol as well as its reduced thermal conductivity. Thermal profiles of the modified materials have been characterized by differential scanning calorimetry, infrared thermography, and by limited wear trials with garments containing the polymeric PCM's. There are other enhanced functional properties of the modified fabrics

  15. Nutritional fibrous osteodystrophy in goats Osteodistrofia fibrosa nutricional em caprinos

    Directory of Open Access Journals (Sweden)

    Paulo M Bandarra

    2011-10-01

    Full Text Available Seven out of 25 goats from a southern Brazilian flock developed nutritional fibrous osteodystrophy. Affected animals were younger than 1 year of age and were confined in stalls and fed a concentrate ration containing 1:6 calcium:phosphorus ratio. The remaining flock (35 goats was managed at pasture and showed no disease. Clinical signs were characterized by mandibular and maxillary enlargements, varying degrees of mouth opening and protruding tongue, dyspnea, apart of abnormalities of prehension and mastication. Affected animals had increased seric levels of phosphorus and parathormone, as well as higher alkaline phosphatase activity. Postmortem examination on three succumbed goats revealed bilateral enlargement of the maxilla and mandibula, and loose teeth, apart of multiple incomplete rib fractures in one of them. Severe diffuse proliferation of loose connective tissue surrounded the osteoid trabeculae, many of which were partially or completely non-mineralized. Mineralized osteoid trabeculae showed osteoclasts in the Howship's lacunae.Sete de um total de 25 caprinos jovens (menos de um ano de idade de um rebanho no sul do Brasil desenvolveram osteodistrofia fibrosa nutricional. Os animais afetados eram confinados em baias e alimentados com concentrado, cuja relação Ca:P era 1:6. O restante do rebanho (35 cabras era mantido na pastagem e não desenvolveu a doença. Os sinais clínicos se caracterizaram por aumento de volume da mandibula e maxila, vários graus de abertura de boca com protrusão da língua, em associação com dispneia e anormalidades de apreensão de alimento e mastigação. Os animais afetados apresentaram os níveis séricos de fósforo e paratormônio aumentados, bem como maior atividade de fosfatase alcalina. Três caprinos foram necropsiados e os achados de necropsia incluíram aumento bilateral da maxi-la e mandíbula, dentes frouxos, além de múltiplas fraturas incompletas de costelas em um caprino. Microscopicamente, havia intensa proliferação de tecido conjuntivo frouxo ao redor de trabéculas ósseas, muitas das quais estavam parcial ou completamente não mineralizadas. Trabéculas ósseas mineralizadas apresentaram osteoclastos em lacunas de Howship.

  16. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Rigali; Mike L. Fulcher

    2003-03-25

    During the reporting period, work continued on development of formulations using the materials down-selected from the initially identified contenders for the fibrous monolith wear resistant components. In the previous reporting period, a two-stage binder removal process was developed that resulted in prototype parts free of voids and other internal defects. During the current reporting period, work was performed to characterize the two-stage binder removal process for WC-Co based FM material systems. Use of this process has resulted in the fabrication of defect free sintered WC-Co FM bodies, with minimal free carbon porosity and densities approaching 100% theoretical. With the elimination of free carbon porosity and other binder removal process related defects, development work focused on optimizing the densification and eliminating defects observed in WC-Co based FM consolidated by pressureless sintering. Shrinkage of the monolithic core and shell materials used in the WC-Co based FM system was measured, and differences in material shrinkage were identified as a potential cause of cell boundary cracking observed in sintered parts. Re-formulation of material blends for this system was begun, with the goal of eliminating mechanical stresses during sintering by matching the volumetric shrinkage of the core and shell materials. Thirty-three 7/8 inch drill bit inserts (WC-Co(6%)/WC-Co(16%) FM) were hot pressed during the reporting period. Six of these inserts were delivered for field-testing by Superior Rock Bit during the upcoming reporting period. In addition, Al{sub 2}O{sub 3}/Al{sub 2}O{sub 3}-TiCN FM cutting tool inserts were fabricated, and cutting tests performed.

  17. Primary malignant small bowel tumor

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Kyung Seung; Suh, Ho Jong; Kim, So Sun; Kim, Ho Joon; Chun, Byung Hee; Joh, Young Duk [Kosin College, Pusan (Korea, Republic of)

    1990-07-15

    Small bowel tumors are rarely detected unless there is intestinal obstruction or bleeding. In the seven years 1982-1988, at Kosin Medical Center, 25 primary malignant small bowel tumors were studied radiographically with barium and / or computed tomography (CT). CT revealed gastrointestinal abnormalities in 20 patients. In ten, lesion were identified by upper G-I series, in 15 by small bowel series, and in addition, in 3 by colon enema. The most common malignant small bowel tumor was adenocarcinoma (N=15) and was next common lymphoma (N=7). On barium study, primary adenocarcinoma appeared as an irregular stricture (66.7%) and polypoid mass with intussusception was most prominent finding in lymphoma. Leiomyosarcoma appeared as an exophytic mass with excavation or ulceration. CT was found to be accurate in detecting wall thickening, complications and other associated findings. In conclusion, barium study was useful in the diagnosis of primary malignant small bowel tumor and CT was more accurate in detecting secondary findings.

  18. Primary malignant small bowel tumor

    International Nuclear Information System (INIS)

    Small bowel tumors are rarely detected unless there is intestinal obstruction or bleeding. In the seven years 1982-1988, at Kosin Medical Center, 25 primary malignant small bowel tumors were studied radiographically with barium and / or computed tomography (CT). CT revealed gastrointestinal abnormalities in 20 patients. In ten, lesion were identified by upper G-I series, in 15 by small bowel series, and in addition, in 3 by colon enema. The most common malignant small bowel tumor was adenocarcinoma (N=15) and was next common lymphoma (N=7). On barium study, primary adenocarcinoma appeared as an irregular stricture (66.7%) and polypoid mass with intussusception was most prominent finding in lymphoma. Leiomyosarcoma appeared as an exophytic mass with excavation or ulceration. CT was found to be accurate in detecting wall thickening, complications and other associated findings. In conclusion, barium study was useful in the diagnosis of primary malignant small bowel tumor and CT was more accurate in detecting secondary findings

  19. The hemostatic system and malignancy.

    Science.gov (United States)

    Adcock, Dorothy M; Fink, Louis M; Marlar, Richard A; Cavallo, Federica; Zangari, Maurizio

    2008-08-01

    There is an intimate relationship between the processes involved in malignancy and hemostasis. The mechanisms by which malignancy promotes thrombosis are reviewed herein. Emphasis, however, is placed upon the potential mechanisms by which the hemostatic system modulates malignant potential of tumors. Both thrombotic and nonthrombotic processes related to the enhancement of tumor growth, angiogenesis, and metastases are presented. Also reviewed are the effects of anticoagulants such as vitamin K antagonists, heparin, and other glycosaminoglycans on survival of patients with cancer. As new anticoagulants and targeted anticancer therapies are developed, we can expect the interactions between coagulation and tumor biology to be an evolving and productive area for breakthroughs in basic science and clinical applications. PMID:18765310

  20. Malignant pleural mesothelioma: update, current management, and newer therapeutic strategies.

    Science.gov (United States)

    Pistolesi, Massimo; Rusthoven, James

    2004-10-01

    The diagnosis and management of malignant pleural mesothelioma are major challenges that often frustrate both patient and clinician alike. Occupational asbestos exposure to crocidolite or amosite forms of the fiber is the most important known risk factor in North America and Western Europe. Other mineral fibers such as erionite, a naturally occurring fibrous zeolite crystal, are associated with mesothelioma in volcanic tuffs of the Cappadocia region of central Anatolia in Turkey. In addition, other possible factors such as the presence of simian virus 40 and genetic susceptibility have been associated recently with the development of mesothelioma in animal models. These latter findings are increasing our understanding of this disease. In addition, the discovery of elevated levels of various markers such as folic acid receptor alpha, cyclooxygenase 2, and multidrug resistance proteins 1 and 2 in mesothelioma tissue have opened up new areas of potential diagnostic and therapeutic importance. However, traditional treatment modalities--surgery, radiotherapy, and chemotherapy--have evolved slowly, and few gains in therapeutic efficacy have occurred. Recently, however, continuing research efforts have led to novel treatment strategies that are changing the way clinicians view a disease that has traditionally been managed with almost universal therapeutic nihilism. This review explores our current knowledge of this disease and presents current and novel therapeutic strategies. PMID:15486399

  1. Malignant diseases as suicidal motives

    Directory of Open Access Journals (Sweden)

    Bogdanovi? Ljiljana

    2007-01-01

    Full Text Available Introduction Suicide is a conscious and intentional destruction of one’s own life, which occurs as a result of mutual influence of a person’s disposition and motives (facts inspiring the commitment of suicide. It is well known that various diseases, including malignancies, could be important and in some cases the only motive for committing suicide. Objective The purpose of the study was to analyze in detail suicides of persons whose only motive was an established malignant disease. Method The analysis was performed using the autopsy material of the Institute of Forensic Medicine, School of Medicine, University of Belgrade, during the period from 1990 to 2004. The reports on performed medico-legal autopsies were used, as well as history data obtained from the family members of suicidal persons, investigation reports and the available medical documents. Results In 1931 cases there was established suicidal nature of a violent death. Neoplasms were the suicidal motive in 37 persons (1.9%. The basic characteristics of the analyzed sample were predominance of males (26:11, ratio 2.4:1, the age of over 70 years and the highest incidence of malignant lung and breast tumors. Almost all cases were the persons who underwent treatment for malignant neoplasms over a longer period of time. During 19 autopsies (51.3% out of 37, a progressive phase of malignancy was established, i.e. metastases. The data on prior oral announcement of suicide intention were obtained for 70.3% (26 cases, and on previous suicidal attempts only for 13.5% (5 cases. In the majority of cases (78.4% the place of committed suicide was the person’s home. In 16 cases (43.2% the suicide was committed with a firearm. Hanging as a manner of destroying one’s own life was chosen by 12 persons (32.4%, while other ways were less frequently used. Conclusion Although malignancies were not present with high incidence as a suicidal motive in our analyzed sample, such cases require particular care of health workers in order to enable the application of adequate measures in the prevention of suicides in persons with malignant diseases. The suicide analyses performed so far indicated that a malignant disease was the motive. Doctors have to show maximal interest for the patient. Prevention is crucial, so the patient should be provided with such surroundings in which the person will not feel alone and abandoned.

  2. Malignant hemangiopericytoma of pituitary fossa

    Directory of Open Access Journals (Sweden)

    Das Prasenjit

    2010-01-01

    Full Text Available Intracranial hemangiopericytomas are rare tumors with aggressive behavior. Other than the meninges, this lesion has rarely been reported in periventricular and sellar region. We report a case of malignant hemangiopericytoma in sellar region in a 47-year-old male who presented with history of sudden onset of bilateral visual disturbances. To best of our knowledge, this is the second case report of malignant hemangiopericytoma in this location. As this intracranial lesion shows aggressive behavior, in the form of recurrence or extracranial metastasis in comparison to its extracranial counterparts, diagnosis should be made cautiously.

  3. Preparation of poly(ethylene glycol/polylactide hybrid fibrous scaffolds for bone tissue engineering

    Directory of Open Access Journals (Sweden)

    Ni P

    2011-11-01

    Full Text Available PeiYan Ni, ShaoZhi Fu, Min Fan, Gang Guo, Shuai Shi, JinRong Peng, Feng Luo, ZhiYong QianState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People's Republic of ChinaAbstract: Polylactide (PLA electrospun fibers have been reported as a scaffold for bone tissue engineering application, however, the great hydrophobicity limits its broad application. In this study, the hybrid amphiphilic poly(ethylene glycol (PEG/hydrophobic PLA fibrous scaffolds exhibited improved morphology with regular and continuous fibers compared to corresponding blank PLA fiber mats. The prepared PEG/PLA fibrous scaffolds favored mesenchymal stem cell (MSC attachment and proliferation by providing an interconnected porous extracellular environment. Meanwhile, MSCs can penetrate into the fibrous scaffold through the interstitial pores and integrate well with the surrounding fibers, which is very important for favorable application in tissue engineering. More importantly, the electrospun hybrid PEG/PLA fibrous scaffolds can enhance MSCs to differentiate into bone-associated cells by comprehensively evaluating the representative markers of the osteogenic procedure with messenger ribonucleic acid quantitation and protein analysis. MSCs on the PEG/PLA fibrous scaffolds presented better differentiation potential with higher messenger ribonucleic acid expression of the earliest osteogenic marker Cbfa-1 and mid-stage osteogenic marker Col I. The significantly higher alkaline phosphatase activity of the PEG/PLA fibrous scaffolds indicated that these can enhance the differentiation of MSCs into osteoblast-like cells. Furthermore, the higher messenger ribonucleic acid level of the late osteogenic differentiation markers OCN (osteocalcin and OPN (osteopontin, accompanied by the positive Alizarin red S staining, showed better maturation of osteogenic induction on the PEG/PLA fibrous scaffolds at the mineralization stage of differentiation. After transplantation into the thigh muscle pouches of rats, and evaluating the inflammatory cells surrounding the scaffolds and the physiological characteristics of the surrounding tissues, the PEG/PLA scaffolds presented good biocompatibility. Based on the good cellular response and excellent osteogenic potential in vitro, as well as the biocompatibility with the surrounding tissues in vivo, the electrospun PEG/PLA fibrous scaffolds could be one of the most promising candidates in bone tissue engineering.Keywords: electrospinning, fibrous scaffolds, poly(ethylene glycol/polylactide, mesenchymal stem cells, bone tissue engineering

  4. Trace-element patterns of fibrous and monocrystalline diamonds: Insights into mantle fluids

    Science.gov (United States)

    Rege, S.; Griffin, W. L.; Pearson, N. J.; Araujo, D.; Zedgenizov, D.; O'Reilly, S. Y.

    2010-08-01

    During their growth diamonds may trap micron-scale inclusions of the fluids from which they grew, and these "time capsules" provide insights into the metasomatic processes that have modified the subcontinental lithospheric mantle. LAM-ICPMS analysis of trace elements in > 500 fibrous and monocrystalline diamonds worldwide has been used to understand the nature of these fluids. Analyses of fibrous diamonds define two general types of pattern, a "fibrous-high" (FH) one with high contents of LREE, Ba and K, and a "fibrous-low" (FL) pattern characterized by depletion in LREE/MREE, Ba and K, negative anomalies in Sr and Y, and subchondritic Zr/Hf and Nb/Ta. Both types may be found in fibrous diamonds from single deposits, and in three Yakutian pipes some diamonds show abrupt transitions from inclusion-rich cores with FH patterns to clearer rims with FL patterns. Most monocrystalline diamonds show FL-type patterns, but some have patterns that resemble those of FH fibrous diamonds. Peridotitic and eclogitic monocrystalline diamonds may show either patterns with relatively flat REE, or patterns with more strongly depleted LREE. Kimberlites that contain peridotitic diamonds with "high" patterns also contain eclogitic diamonds with "high" patterns. Strong similarities in the patterns of these two groups of diamonds may suggest high fluid/rock ratios. Many diamonds of the "superdeep" paragenesis have trace-element patterns similar to those of other monocrystalline diamonds. This may be evidence that the trace-element compositions of deep-seated fluids are generally similar to those that form diamonds in the subcontinental lithospheric mantle. The element fractionations observed between the FH and FL patterns are consistent with the immiscible separation of a silicic fluid from a carbonatite-silicate fluid, leaving a residual carbonatitic fluid strongly enriched in LREE, Ba and alkalies. This model would suggest that most monocrystalline diamonds crystallized from the more silicic fraction. Comparison with studies of single fluid inclusions in fibrous diamonds suggests that the FH patterns reflect trapped inclusions of high-Mg and low-Mg carbonatitic high-density fluids. In terms of the rock-forming elements, the fluids that precipitated the rims of some fibrous diamonds (FL pattern) and most monocrystalline diamonds are broadly similar to some hydro-silicic high-density fluids found in fibrous diamonds. However, there are still significant differences between the trace-element patterns of most monocrystalline diamonds and known high-density fluids, and further research is required to understand the formation and growth of these diamonds.

  5. Evaluation of sodium sulfite and protein correction in analyses of fibrous compounds in tropical forages

    Scientific Electronic Library Online (English)

    Daiany Íris, Gomes; Edenio, Detmann; Sebastião de Campos, Valadares Filho; Rafael, Mezzomo; Natália Krish de Paiva, Souza; Augusto César de, Queiroz; Kelly da Silva Coutinho, Detmann.

    2012-01-01

    Full Text Available The objective of this study was to evaluate the contents of fibrous compounds in tropical grasses and legumes according to utilization of sodium sulfite in the neutral detergent solution or using a procedure for contaminant protein correction. Samples of ten grasses and ten legumes were used. The co [...] ntents of neutral detergent fiber were decreased when sodium sulfite was used; however, more prominent reductions were verified in legumes. Sodium sulfite decreased the acid detergent fiber content in both forage groups. The contents of neutral and acid detergent insoluble protein and lignin were reduced by sodium sulfite in legumes, but no effect was observed in grasses with regard to these variables. The decrease in fiber contents in legumes could be explained by the solubilization of lignin and decrease in insoluble nitrogen. However, the decreases in fiber in grasses could not be solely explained by the decrease in contaminant protein and solubilization of lignin, and loss of other fibrous compounds probably occurred. The utilization of sodium sulfite compromises the accuracy of the estimates of fibrous compounds contents in tropical forages. The precision of the estimates were not relevantly increased by sodium sulfite. The correction of insoluble fibrous compounds for protein is suggested instead of using sodium sulfite because there are no modifications on neutral detergent solution or undesirable solubilization of fibrous compounds.

  6. Evaluation of sodium sulfite and protein correction in analyses of fibrous compounds in tropical forages

    Directory of Open Access Journals (Sweden)

    Daiany Íris Gomes

    2012-01-01

    Full Text Available The objective of this study was to evaluate the contents of fibrous compounds in tropical grasses and legumes according to utilization of sodium sulfite in the neutral detergent solution or using a procedure for contaminant protein correction. Samples of ten grasses and ten legumes were used. The contents of neutral detergent fiber were decreased when sodium sulfite was used; however, more prominent reductions were verified in legumes. Sodium sulfite decreased the acid detergent fiber content in both forage groups. The contents of neutral and acid detergent insoluble protein and lignin were reduced by sodium sulfite in legumes, but no effect was observed in grasses with regard to these variables. The decrease in fiber contents in legumes could be explained by the solubilization of lignin and decrease in insoluble nitrogen. However, the decreases in fiber in grasses could not be solely explained by the decrease in contaminant protein and solubilization of lignin, and loss of other fibrous compounds probably occurred. The utilization of sodium sulfite compromises the accuracy of the estimates of fibrous compounds contents in tropical forages. The precision of the estimates were not relevantly increased by sodium sulfite. The correction of insoluble fibrous compounds for protein is suggested instead of using sodium sulfite because there are no modifications on neutral detergent solution or undesirable solubilization of fibrous compounds.

  7. Adsorption kinetics and isotherms of zeolite coatings directly crystallized on fibrous plates for heat pump applications

    International Nuclear Information System (INIS)

    Zeolite A coatings were grown on porous fibrous metal plates by using the substrate heating synthesis method. The coatings prepared were characterized by X-ray diffraction (XRD) and laser microscopy. Kinetic measurements were performed to determine the rates of adsorption of these materials while their adsorption isotherms were obtained by thermogravimetry (TG). The overall adsorption kinetics varied with the different samples investigated. The zeolite A coating grown on a copper fibrous support generally exhibited superior overall adsorption kinetics compared to a zeolite X coating with close mass, prepared previously on a stainless steel flat plate. The coating thickness as well as the support properties affected the performances of the samples. The inclusion of an additional polymer layer exhibited adverse impact on the kinetics especially after relatively high normalized loadings. The adsorption isotherms obtained for the zeolite coatings on fibrous supports were quite typical for zeolite A while the addition of polymer changed the isotherm type. -- Highlights: • Thick zeolite A coatings were grown on fibrous metal plates. • Use of fibrous supports improved heat transfer quality. • Coating thickness influenced adsorption kinetics notably. • Inclusion of an additional polymer layer changed kinetics and isotherm type

  8. Non-oxidative and oxidative torrefaction characterization and SEM observations of fibrous and ligneous biomass

    International Nuclear Information System (INIS)

    Highlights: • Non-oxidative and oxidative torrefaction of biomass is studied. • Two fibrous biomasses and two ligneous biomasses are tested. • SEM observations of four biomasses are provided. • Fibrous biomass is more sensitive to O2 concentration than ligneous biomass. • The performance of non-oxidative torrefaction is better than that of oxidative torrefaction. - Abstract: Oxidative torrefaction is a method to reduce the operating cost of upgrading biomass. To understand the potential of oxidative torrefaction and its impact on the internal structure of biomass, non-oxidative and oxidative torrefaction of two fibrous biomass materials (oil palm fiber and coconut fiber) and two ligneous ones (eucalyptus and Cryptomeria japonica) at 300 °C for 1 h are studied and compared with each other. Scanning electron microscope (SEM) observations are also performed to explore the impact of torrefaction atmosphere on the lignocellulosic structure of biomass. The results indicate that the fibrous biomass is more sensitive to O2 concentration than the ligneous biomass. In oxidative torrefaction, an increase in O2 concentration decreases the solid yield. The energy yield is linearly proportional to the solid yield, which is opposite to the behavior of non-oxidative torrefaction. The performance of non-oxidative torrefaction is better than that of oxidative torrefaction. As a whole, ligneous biomass can be torrefied in oxidative environments at lower O2 concentrations, whereas fibrous biomass is more suitable for non-oxidative torrefaction

  9. Highly elastic and suturable electrospun poly(glycerol sebacate) fibrous scaffolds.

    Science.gov (United States)

    Jeffries, Eric M; Allen, Robert A; Gao, Jin; Pesce, Matt; Wang, Yadong

    2015-05-01

    Poly(glycerol sebacate) (PGS) is a thermally-crosslinked elastomer suitable for tissue regeneration due to its elasticity, degradability, and pro-regenerative inflammatory response. Pores in PGS scaffolds are typically introduced by porogen leaching, which compromises strength. Methods for producing fibrous PGS scaffolds are very limited. Electrospinning is the most widely used method for laboratory scale production of fibrous scaffolds. Electrospinning PGS by itself is challenging, necessitating a carrier polymer which can affect material properties if not removed. We report a simple electrospinning method to produce distinct PGS fibers while maintaining the desired mechanical and cytocompatibility properties of thermally crosslinked PGS. Fibrous PGS demonstrated 5 times higher tensile strength and increased suture retention compared to porous PGS foams. Additionally, similar modulus and elastic recovery were observed. A final advantage of fibrous PGS sheets is the ability to create multi-laminate constructs due to fiber bonding that occurs during thermal crosslinking. Taken together, these highly elastic fibrous PGS scaffolds will enable new approaches in tissue engineering and regenerative medicine. PMID:25686558

  10. The internal microstructure and fibrous mineralogy of fly ash from coal-burning power stations

    International Nuclear Information System (INIS)

    Coal fly ash (CFA) is a significant environmental pollutant that presents a respiratory hazard when airborne. Although previous studies have identified the mineral components of CFA, there is a paucity of information on the structural habits of these minerals. Samples from UK, Polish and Chinese power stations were studied to further our understanding of the factors that affect CFA geochemistry and mineralogy. ICP-MS, FE-SEM/EDX, XRD, and laser diffraction were used to study physicochemical characteristics. Analysis revealed important differences in the elemental compositions and particle size distributions of samples between sites. Microscopy of HF acid-etched CFA revealed the mullite present possesses a fibrous habit; fibres ranged in length between 1 and 10 ?m. Respirable particles (<10 ?m) were frequently observed to contain fibrous mullite. We propose that the biopersistence of these refractory fibres in the lung environment could be contributing towards chronic lung diseases seen in communities and individuals continually exposed to high levels of CFA. - Highlights: ? Chinese CFA had a greater crystalline mineral content and smaller particle size. ? Mullite and quartz, two hazardous minerals, recrystallise from glass melt particles. ? Mullite revealed a fibrous habit, with fibres 1-10 ?m in length and 0.5-1 ?m in width. - Chinese CFA possessed a greater crystalline mineral content and smaller particle size than UK and Polish CFA, the fibrous mullite prlish CFA, the fibrous mullite prhiesent displayed a high aspect-ratio and thus is likely to be a respiratory hazard in vivo.

  11. Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma

    Science.gov (United States)

    2015-01-05

    Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Desmoplastic Small Round Cell Tumor; Adult Epithelioid Hemangioendothelioma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Rhabdomyosarcoma; Adult Synovial Sarcoma; Childhood Alveolar Soft-part Sarcoma; Childhood Angiosarcoma; Childhood Desmoplastic Small Round Cell Tumor; Childhood Epithelioid Hemangioendothelioma; Childhood Epithelioid Sarcoma; Childhood Fibrosarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Hemangiopericytoma; Childhood Malignant Mesenchymoma; Childhood Neurofibrosarcoma; Childhood Synovial Sarcoma; Dermatofibrosarcoma Protuberans; Metastatic Childhood Soft Tissue Sarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Childhood Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

  12. MR Imaging Findings of Ovarian Cystadenofibroma: Clues for Making the Differential Diagnosis from Ovarian Malignancy

    International Nuclear Information System (INIS)

    Ovarian cystadenofibromas are uncommon epithelial ovarian tumors in which fibrous stroma is the dominant component of the neoplasm, in addition to the epithelial lining of the cystic tumor. These tumors are classified, according to the epithelial cell types, into the serous, endometrioid, mucinous, clear cell and mixed categories. Outwater et al. have reported that ovarian cystadenofibromas were multilocular cystic masses with a solid component and they had a specific MR signal intensity for the solid portion, which consisted of fibrous tissue that had very low signal intensity on the T2-weighted sequences. Takeuchi et al. reported that small or tiny cystic locules within the solid component are the characteristic findings of cystadenofibroma, corresponding to a black sponge-like appearance on T2-weignted image. Cho et al. found that about half of ovarian cystadenofibromas are purely cystic and the other half are complex cystic masses with one or more solid components on CT or MR imaging. The imaging findings of purely cystic ovarian cystadenofibromas were identical to those of ovarian cystadenomas on CT or MR imaging. Upon reviewing of the pathology of these tumors, they had small foci of fibrous stromas that were detected only on microscopic examination. The cystadenofibromas with a complex cystic nature demonstrated variable amounts of solid components in the cystic tumor on the CT or MR imaging. Familiarity with the above mentioned MR imaging features of ovarian cmentioned MR imaging features of ovarian cystadenofibromas may allow a specific diagnosis and help distinguish this benign tumor from malignant tumors, and this can be a big help during surgical planning to avoid inappropriate management or excessive surgical intervention

  13. Malignant transformation of uterine leiomyoma

    OpenAIRE

    Al Ansari, Afaf A.; Al Hail, Fatima A.; Abboud, Emad

    2013-01-01

    A rare case of malignant transformation of uterine leiomyoma is reported. A 54 year old lady, nulliparous and 2 years postmenopausal presented to gynecology clinic with a pelvi – abdominal mass and ultrasound scan suggestive of multiple uterine fibroid. Total abdominal hysterectomy performed. Histopathology report showed leiomyosarcomative changes from benign leiomyoma within the huge mass.

  14. The Origin of Malignant Malaria

    Science.gov (United States)

    Plasmodium falciparum is the causative agent of malignant malaria, which is among the most severe human infectious diseases. Despite its overwhelming significance to human health, the parasite’s origins remain unclear. The favored origin hypothesis holds that P. falciparum and its closest known rel...

  15. Malignant nodular hidradenoma of scalp

    Science.gov (United States)

    Maiti, Tanmoy; Somanna, Sampath; Devi, Bhagavatula Indira; Unchagi, Asha; Shukla, Dhaval

    2014-01-01

    Malignant nodular hidradenoma (MNH) is a rare tumor of sweat gland known by many names in the literature. Scalp is a known and yet uncommon site of occurrence. We describe two patients with scalp MNH with brain parenchymal invasion. Both tumors recurred in spite of total excision and radiotherapy. PMID:25288856

  16. Malignant mesothelioma of the pleura

    International Nuclear Information System (INIS)

    Characteristics, symptoms, diagnosis of malignant mesothelioma of the pleura are given. Methods of its treatment - radiotherapy as distant radiation by integral doses from 20 to 50 Gy, combined treatment (operation, post-operative radiation) and comprehensive therapy (irradiation and drug therapy) are described

  17. Cutaneous malignancies of the perineum.

    Science.gov (United States)

    Carr, David; Pootrakul, Llana; Harmon, Jenna; Trotter, Shannon

    2015-03-01

    This review discusses multiple cutaneous malignancies that can present on the perineum. Although all of these neoplasms are uncommon, a focus will be on the more common neoplasms including extramammary Paget disease, basal cell carcinoma, squamous cell carcinoma, and melanoma. Other more rare entities discussed are superficial leiomyosarcoma, giant solitary trichoepithelioma, and cutaneous endometriosis. PMID:25517758

  18. Chemoradiation therapy for malignant neoplasms

    International Nuclear Information System (INIS)

    The experience of chemoradiation therapy of malignant tumors is reviewed. Methods and results of treating tumors of lungs, stomach, throat and urine bladder are presented in detail. The necessity of mutual investigations in the field of chemoradiation therapy of oncological patients according to a unified system is underlined

  19. Brain Malignancies Steering Committee Roster

    Science.gov (United States)

    Brain Malignancies Steering Committee Roster Co-chairs Ian Pollack, M.D., F.A.C.S., F.A.A.PChildren's Hospital of PittsburghPittsburgh, PA W.K. Alfred Yung, M.D.University of Texas - M.D. Anderson Cancer CenterHouston, TX Members Karla Ballman, Ph.D.Mayo

  20. Neuroleptic Malignant Syndrome: A Review

    OpenAIRE

    O Brien, Richard A.; Young, G. Bryan

    1989-01-01

    There has recently been interest in neuroleptic malignant syndrome (NMS) as the disorder has been better characterized. Nms is still poorly recognized, however, by most physicians. Hyperpyrexia, rigidity, altered consciousness, autonomic instability, and enzymatic evidence of muscle breakdown after drug intake are the cardinal features. The authors of this article review the proposed pathogenesis, complications, and treatment of NMS.

  1. Malignant neurilemoma with xeroderma pigmentosum

    Science.gov (United States)

    Wang, Li Na; Ma, Min Jian; Shi, Ji Tong

    2009-01-01

    Xeroderma pigmentosum is a rare autosomal recessive disease characterised by hypersensitivity to sunlight, and is associated with a high incidence of skin cancer. We report a case of xeroderma pigmentosum with malignant neurilemoma in a 46-year-old woman which is unique due to its presentation, which was confirmed histopathologically. Trial registration number: 31095 PMID:21686923

  2. Haematological malignancy in the adult

    International Nuclear Information System (INIS)

    The emphasis in this chapter has been placed on those aspects of treatment of the following haematological malignancies of particular relevance to the radiotherapist: acute lymphoblastic leukemia, acute non-lymphocytic leukemia, chronic granulocytic leukemia, chronic lymphocytic leukemia extramedullary leukemic deposits, granulocytic sarcoma, polycythaemia rubra vera, myelofibrosis, multiple myeloma, solitary plasmacytoma. (U.K.)

  3. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Rigali

    2001-08-15

    A set of materials property data for potential wear resistant materials was collected. These materials are designated for use as the ''core'' materials in the Fibrous Monolith structure. The material properties of hardness, toughness, thermal conductivity and cost were selected as determining factors for material choice. Data for these four properties were normalized, and weighting factors were assigned for each property to establish priority and evaluate the effects of priority fluctuation. Materials were then given a score based on the normalized parameters and weighting values. Using the initial estimates for parameter priority, the highest ranking material was tungsten carbide, with diamond as the second ranked material. Several materials were included in the trade study, and five were selected as promising ''core'' materials to include in this effort. These materials are tungsten carbide, diamond, boron carbide, titanium diboride and silicon carbide. Work was initiated on a trade study to evaluate ''shell'' materials. These materials will require the investigation of different material properties, including ultimate tensile strength, ductility, toughness, thermal expansion, thermal conductivity and compatibility during consolidation with the ''core'' materials. Kyocera Industrial Ceramics in Kyoto, Japan was visited, with the purpose of negotiating and signing the subcontract for Kyocera's participation on this program. An assessment was made on the testing and manufacturing capabilities of Kyocera and how such capabilities can be integrated into our development effort. Tours were conducted of Kyocera's machine tool production plant in Sendai, Japan, as well as their research and development facilities in Kagoshima, Japan. Kyocera's facilities include substantial materials characterization and testing capabilities at room and elevated temperatures, and manufacturing capabilities of thousands of parts/hr, all of which will be made available to us for use on this program as part of Kyocera's in-kind program cost share contribution. The Kyocera subcontract and the details of Kyocera's participation on this program were discussed and agreed upon during the two-day meeting (see Attachment A). Kennametals's Vice President and Chief Technical joined discussions regarding potential 3-way collaborations between Kyocera, ACR Inc. and Kennametal. This collaboration would involve the utilization of Kennametal's Rapid Omni-Directional Compaction Process (ROC Process) in the production of FM-based cutting tools. Kyocera and ARC Inc are in the process of evaluating the potential of this process in the fabrication of wear resistant composite tooling.

  4. Orbital and periorbital fibrous dysplasia and ossifying fibroma with special reference to computed tomography

    International Nuclear Information System (INIS)

    Fibro-osseous conditions affecting the craniofacial bones pose a complex diagnostic problem. Differentiation between monostotic fibrous dysplasia (FD) and ossifying fibroma (OF) is only possible by correlation of clinical, radiographical andhistopathological features. CT was superior to conventional radiography/polytomography in defining exact extent and site of lesions and additional lesions, in verifying aetiology of secondary complications, as well as in depicting lesions and tandem lesions simulating FD and OF. Density of fibro-osseous conditions was variable due to the ratio of fibrous stroma and metaplastic bone present. Density measurements in FD were 32-695 HU, in immature types of OF, consisting mainly of fibrous and osteoid tissue, 30-250 HU and could reach 690 HU in mature OF, but were definitively lower than normal bone in all our cases. Focal intrinsic inhomogenity was more significant in mixed types of FD and immature OF. (orig.)

  5. Solitary fibrous tumor of the spinal nerve rootlet: report of a case mimicking schwannoma.

    Science.gov (United States)

    Piana, Simonetta; Putrino, Innocenza; Cavazza, Alberto; Nigrisoli, Evandro

    2004-03-01

    We report a case of solitary fibrous tumor involving the spinal nerve root at the L1-L2 level in a 67-year-old man. The patient presented with lumbar pain and weakness in his right lower extremity. Histologically, the tumor was composed of a proliferation of monomorphous spindle cells in an abundant collagenous stroma; neither necrosis nor mitoses were evident. These cells were strongly immunoreactive with CD34, Bcl-2, CD99, and vimentin, but were negative with S100 protein, smooth muscle actin, and epithelial membrane antigen. Such an immunohistochemical profile was consistent with a solitary fibrous tumor of the spinal nerve rootlet and ruled out the main differential diagnoses, schwannoma and meningioma. The present case suggests that solitary fibrous tumor should be considered in differentiating spindle cell lesions of the spinal cord and nerve rootlet. PMID:14987150

  6. Solitary fibrous tumor of the male breast: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Sessa Fausto

    2008-02-01

    Full Text Available Abstract Extrapleural solitary fibrous tumors are very rare and occasionally they appear in extraserosal soft tissues or parenchymatous organs. In such cases the right preoperative diagnosis is often difficult and challenging, because both radiological and cytological examinations are not exhaustive. For these reasons, surgical excision is frequently the only way to reach the correct diagnosis and to achieve definitive treatment. A few cases of solitary fibrous tumors have been also described in the breast. Although rare, this lesion opens difficulties in preoperative diagnosis entering in differential diagnosis with other benign lesions as well as with breast cancer. In this article we describe a case of a solitary fibrous tumor of the breast in a 49-year-old man. Problems related to differential diagnosis and the possible pitfalls that can be encountered in the diagnostic iter of such rare tumor are discussed.

  7. Solitary fibrous tumor of the male breast: a case report and review of the literature.

    Science.gov (United States)

    Rovera, Francesca; Imbriglio, Giovanna; Limonta, Giorgio; Marelli, Marina; La Rosa, Stefano; Sessa, Fausto; Dionigi, Gianlorenzo; Boni, Luigi; Dionigi, Renzo

    2008-01-01

    Extrapleural solitary fibrous tumors are very rare and occasionally they appear in extraserosal soft tissues or parenchymatous organs. In such cases the right preoperative diagnosis is often difficult and challenging, because both radiological and cytological examinations are not exhaustive. For these reasons, surgical excision is frequently the only way to reach the correct diagnosis and to achieve definitive treatment. A few cases of solitary fibrous tumors have been also described in the breast. Although rare, this lesion opens difficulties in preoperative diagnosis entering in differential diagnosis with other benign lesions as well as with breast cancer. In this article we describe a case of a solitary fibrous tumor of the breast in a 49-year-old man. Problems related to differential diagnosis and the possible pitfalls that can be encountered in the diagnostic iter of such rare tumor are discussed. PMID:18254983

  8. Micromechanics approach to the magnetoelectric properties of laminate and fibrous piezoelectric/magnetostrictive composites

    Science.gov (United States)

    Huang, Haitao; Zhou, Li Min

    2004-12-01

    We use a micromechanics approach to study the magnetoelectric (ME) properties of the piezoelectric/magnetostrictive composite with a 2-2 laminate structure and a 3-1 fibrous structure. It is found that the 3-1 composite has a higher ME coefficient than the 2-2 one, if the volume ratio of piezoelectric material is the same. The reason is that the 3-1 fibrous composite makes use of the longitudinal piezoelectric response and the piezoelectric voltage constant g33 is 2-3 times that of g31. Generally, a smaller volume ratio of the piezoelectric material will generate a higher ME response. The tensile stress at the piezoelectric/magnetostrictive interface of the 3-1 fibrous composite, however, could be high enough to induce plastic deformation or microcracks, which leads to a ME coefficient lower than the theoretically predicted one.

  9. Animal models of malignant mesothelioma.

    Science.gov (United States)

    Kane, Agnes B

    2006-11-01

    Animal models of diffuse malignant mesothelioma have historically been used to assess carcinogenicity of various fiber types and to study the pathogenesis of this unusual neoplasm. Pleural and peritoneal mesotheliomas have been induced in rodents following exposure to erionite or asbestos fibers, radionuclides, particulate nickel compounds, and chemicals such as 3-methylcholanthrene. The role of SV40 virus as a cofactor with asbestos fibers in the development of diffuse malignant mesotheliomas in humans has been explored in animal models. SV40 virus alone induces mesotheliomas in hamsters. Generation of new transgenic mouse strains with targeted expression of SV40 large T and small t antigens in the mesothelium would be very useful for mechanistic studies. Human malignant mesotheliomas frequently show hypermethylation or deletions at the Cdkn2a/Arf and Cdkn2b gene loci and deletions or mutations at the NF2 gene locus. Heterozygous Nf2 (+/-) mice exposed to crocidolite asbestos fibers exhibited accelerated development of malignant mesotheliomas compared to wild-type littermates. Loss of the wild-type Nf2 allele, leading to biallelic inactivation, was observed in nine mesothelioma cell lines derived from Nf2 (+/-) mice. Similar to human malignant mesotheliomas, tumors from Nf2 (+/-) mice showed frequent homozygous deletions of the Cdkn2a/Arf locus and adjacent Cdkn2b tumor suppressor gene. As in the human disease, murine mesotheliomas also showed constitutive activation of Akt. This murine model of asbestos carcinogenesis recapitulates the molecular and histopathological features of the human disease and has significant implications for preclinical testing of novel preventive or therapeutic modalities. PMID:16920675

  10. Malignant Hyperthermia Association of the United States

    Science.gov (United States)

    ... Shop Official MHAUS Home Page What Is MH? Malignant hyperthermia (MH) is a potentially fatal, inherited disorder ... Donations Save Lives! January 7, 2015 Anesthesia Provider Malignant Hyperthermia Experiences Survey December 31, 2014 Fiscal Year ...

  11. Serum ferritin in liver and bone malignancy

    International Nuclear Information System (INIS)

    Serum ferritin concentration is increased during iron overload, however, during chronic infection and malignant diseases as well. In 383 patients with proven malignancy or suspicion of a malignant disease liver and/or bone scans were performed and serum ferritin was measured in addition. Although there exists a certain linkage between the tumorous disease and serum ferritin level, a definite correlation does not exist. Furthermore serum ferritin is not a measure to differentiate between infectious and malignant diseases. (orig.)

  12. Case for diagnosis

    Scientific Electronic Library Online (English)

    Felipe Maurício Soeiro, Sampaio; Gustavo Vieira, Gualberto; Fernando Gustavo Mósca de, Cerqueira; Ana Maria Mósca de, Cerqueira; Curt Mafra, Treu; Thiago Jeunon de Sousa, Vargas.

    2014-06-01

    Full Text Available SciELO Brazil | Language: English Abstract in english We report the case of an 11-year-old male patient with a histopathological and immunohistochemical diagnosis of dermatofibroma with an atypical clinical presentation on the right forearm. Although dermatofibroma is considered a benign skin tumor, some of its differential diagnoses, such as dermatofi [...] brosarcoma protuberans and malignant fibrous histiocytoma, are truly aggressive. Lesions with atypical clinical aspects and topology associated with specific histopathological variants are some of the criteria for complete tumor excision.

  13. Dedifferentiated parosteal osteosarcoma with giant cell tumor component

    International Nuclear Information System (INIS)

    Dedifferentiated parosteal osteosarcoma is characterized histologically by the admixture of low-grade fibroblastic osteosarcoma and a high-grade component typically resembling conventional osteosarcoma or malignant fibrous histiocytoma. We report an unusual distal femoral dedifferentiated parosteal osteosarcoma in which the dedifferentiated component resembled a giant cell tumor of bone. This phenotype is rarely described in the dedifferentiated component of a dedifferentiated parosteal osteosarcoma. The clinical, radiographic, and pathologic features of this unusual tumor are described to further expand the histologic spectrum of dedifferentiated parosteal osteosarcoma. (orig.)

  14. Postirradiation osteosarcoma

    International Nuclear Information System (INIS)

    We are reporting a case of postirradiation osteosarcoma. A seventy-six-year-old female was admitted to Kumamoto University Hospital in 1978 because of tumor of right Knee. This soft part tumor was resected completely and histological finding were those of Malignant Fibrous Histiocytoma. This patient received radiation therapy in the form of cobalt-60 to this region. Dosage was calculated to be 50 Gy. In 1984, she was admitted for the tumor of right tibia. X-ray revealed severe osteoblastic change. Amputation above knee was performed and examination of the surgical specimen showed findings of osteosarcoma. We thought this tumor was postirradiation osteosarcoma corresponding to Arlen's criteria. (author)

  15. The extensor carpi radialis longus muscle flap for anterior elbow coverage.

    Science.gov (United States)

    Janevicius, R V; Greager, J A

    1992-01-01

    A muscle group resection for treatment of malignant fibrous histiocytoma of the distal arm exposed a 15 cm length of radial nerve. The soft tissue defect and radial nerve were covered with an extensor carpi radialis longus muscle island flap. The proximal dominant vascular pedicle enabled extensive mobilization and transposition of this muscle to cover the defect while preserving normal elbow, radial nerve, and hand function. Because of its ease of elevation, extensive arc of rotation, and its expendability, the extensor carpi radialis longus muscle flap should be considered as an option for reconstruction of defects about the elbow joint. PMID:1311341

  16. Endemic pleural disease associated with exposure to mixed fibrous dust in Turkey.

    Science.gov (United States)

    Rohl, A N; Langer, A M; Moncure, G; Selikoff, I J; Fischbein, A

    1982-04-30

    Pleural mesothelioma, lung cancer, pleural calcification and fibrosis, and interstitial parenchymal fibrosis have been observed among inhabitants of several villages in south-central Turkey. Earlier reports have stated that environmental and lung tissue samples from this area contained the fibrous zeolite mineral erionite, and this mineral has generally been assumed to be the agent responsible for these endemic pathological conditions in the absence of asbestos outcroppings and usage. Several different kinds of asbestos minerals in addition to erionite have now been found in environmental samples taken from the villages where these diseases occur. The lung tissues of mesothelioma patients from these villages contain both fibrous zeolites and asbestos minerals. PMID:7071597

  17. Exploiting BSA to Inhibit the Fibrous Aggregation of Magnetic Nanoparticles under an Alternating Magnetic Field

    Directory of Open Access Journals (Sweden)

    Ning Gu

    2013-03-01

    Full Text Available The alternating magnetic field was discovered to be capable of inducing the fibrous aggregation of magnetic nanoparticles. However, this anisotropic aggregation may be unfavorable for practical applications. Here, we reported that the adsorption of BSA (bovine serum albumin on the surfaces of magnetic nanoparticles can effectively make the fibrous aggregation of ?-Fe2O3 nanoparticles turn into a more isotropic aggregation in the presence of the alternating magnetic field. Also, the heating curves with and without BSA adsorption under different pH conditions were measured to show the influence of the colloidal aggregation states on the collective calorific behavior of magnetic nanoparticles.

  18. Primary Solitary Fibrous Tumor of the Thyroid - Report of a Case and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Zhigang Song, Chunkai Yu, Xin Song, Lixin Wei, Aijun Liu

    2011-01-01

    Full Text Available Solitary fibrous tumor (SFT is a rare spindle-cell neoplasm, especially in the thyroid. We report a case of primary solitary fibrous tumor of the thyroid gland in a 37 year-old Chinese man. The tumor was characterized by bland-looking spindle cells admixed with thin and thick collagen fibers. On immunohistochemistry study indicated that tumor cells were diffusely positive for CD34, Bcl-2 and CD99, and negative for Desmin, NSE, SMA, S-100, and CD68. The patient remains well 16 months after excision. The morphologic and immunohistochemical features of the thyroid SFTs are similar to their reported counterparts in other anatomic sites.

  19. Heat and Mass Transport through Porous Fibrous Insulation: Modeling and Optimization

    Science.gov (United States)

    Fan, Jintu; Du, Ning; Wu, Huijun; Sun, Weiwei

    2010-05-01

    This paper provides an overview of our recent theoretical and experimental investigations into the complex phenomenon of heat and moisture transport through porous fibrous insulation aimed at improved understanding of the mechanisms involved. Our improved transient model, integrating conductive and radiative heat transfer, moisture diffusion, moisture bulk flow, moisture sorption and desorption as well as phase change were validated by subzero experiments on a novel sweating guarded hot plates. Our work is further extended to optimize the porous fibrous insulations for maximizing the thermal insulation and moisture transmission for various applications.

  20. Malignant pleural mesothelioma due to environmental mineral fiber exposure in Turkey. Analysis of 135 cases.

    Science.gov (United States)

    Selçuk, Z T; Cöplü, L; Emri, S; Kalyoncu, A F; Sahin, A A; Bari?, Y I

    1992-09-01

    We reviewed data from 135 patients with environment-associated malignant pleural mesothelioma (MPM) from the Central Anatolian region of Turkey. The most significant factors suggesting the diagnosis of MPM were the village where the patient resided and the typical presenting symptoms and signs of unilateral exudative pleural effusion associated with nonpleuritic chest pain. Computed tomography and ultrasonography were very useful for evaluating the extension of the tumor in the thoracic and abdominal cavities and chest wall. The tissue diagnosis was established by either thoracoscopy (39 percent) or pleural biopsy (39 percent) in the majority of the cases. The median survival after diagnosis was 13.52 months for erionite-associated MPM and 21.56 months for asbestos-associated MPM. The actuarial survival curves for the fibrous minerals were significantly different for survival computed both from onset of the symptoms and after diagnosis. Medical or surgical treatment or both did not change the outcome of the disease. PMID:1325339