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Sample records for malignant fibrous histiocytomas

  1. Malignant fibrous histiocytoma of bone

    This is the case history of a 19-year old patient in whom a malignant tumour was found 8 years after radiotherapy of Hodgkin's disease. After some classification difficulties the tumour, which was located in the radiation-exposed proximal region of the humerus, was identified as a malignant fibrous histiocytoma. (orig./AJ)

  2. Primary malignant fibrous histiocytoma of the mediastinum.

    Morshuis, W. J.; Cox, A. L.; Lacquet, L K; Mravunac, M.; Barentsz, J.O.

    1990-01-01

    A malignant fibrous histiocytoma of the mediastinum was successfully treated by surgery and radiotherapy. Magnetic resonance imaging was able to show the site of invasion, the two different components of the tumour, and the blood supply.

  3. Malignant fibrous histiocytoma of the spleen

    Šipovac Dragana

    2014-01-01

    Introduction. Since the first description of primary splenic malignant fibrous histiocytoma given by Govoni et al. in 1982, there have been only 18 reported cases by the end of 2013. We herein reported a case of rare primary malignant fibrous histiocytoma of the spleen with liver metastases and unspecific general symptoms. Case Report. A 62-year-old cachectic female complained of sharp strong abdominal pain (on the pain scale 8/10) and distaste for food on ...

  4. A case of intracranial malignant fibrous histiocytoma

    Amir Hossein Sarrami

    2011-01-01

    Full Text Available We describe a case of intracranial malignant fibrous histiocytoma which had infiltrated pons, cerebellum and basal surface of left temporal lobe without any visible mass. The patient presented with a sudden loss of consciousness and vomiting. Clinical findings, laboratory tests, imaging and examination of the cerebrospinal fluid tended to establish the diagnosis of an infectious condition than a malignancy. Without any response to the antibiotics and with a progressive deterioration of neurologic and mental condition, the patient died after 20 days. In the autopsy, histological and immunohistochemical study of the brain revealed the diagnosis of malignant fibrous histiocytoma (MFH.

  5. Malignant fibrous histiocytoma with skeletal involvement

    Takechi,Hideo

    1978-10-01

    Full Text Available Malignant fibrous histiocytoma of soft part is rather common but malignant fibrous histiocytoma of the bone is rarely encountered clinically. Authors present five cases of malignant fibrous histiocytoma with skeletal involvement and discuss their clinical course, x-ray findings and histological features. This tumor has marked tendency for local recurrence and metastasis. Other bone tumors such as giant cell tumor, aneurysmal bone cyst, non ossifying fibroma, osteosarcoma, fibrosarcoma of bone and metastatic cancer can be excluded by several characteristic findings observed in x-rays as well as histopathological features. All information on the patient should be carefully analysed, because it is difficult to decide whether bone involvement is primary or secondary. Four out of five cases definitely originated within the bone.

  6. Malignant Fibrous Histiocytoma in the Infratemporal Fossa

    Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in late adult life, but its incidence in oral and maxillofacial region is extremely rare. We report a case of malignant fibrous histiocytoma which occurred in the infratemporal fossa. Conventional radiograph of this case showed an ill-defined radiolucent lesion in the alveolar bone of the right maxillary first molar area, the lateral wall of the maxillary sinus, and the ascending ramus of mandible. MRI demonstrated well defined mass of intermediate signal intensity in T1 weighted images but T2 weighted images showed two distinctive regions of different characteristics. Infratemporal portion of the lesion was of hyperintense signal but under that region, the signal intensity decreased clearly, which might mean this case composed of two different subtypes, though it couldn't be confirmed by histopathological examination. Biopsy was taken in the only soft tissue of the maxillary posterior alveolar region and confirmed the lesion as the storiform-pleomorphic type of malignant fibrous histiocytoma. Histopathological subtype was well consistent with the relatively aggressive imaging findings of that region. We expect more detailed analysis of the nature of malignant fibrous histiocytoma with improvement of the imaging modality and the identification of the relationship between diagnostic imaging and histopathologic findings.

  7. Malignant Fibrous Histiocytoma in the Infratemporal Fossa

    Lee, Kyung Hee; Heo, Min Suk; Lee, Sam Sun; Choi, Soon Chul [Dept. of Oral and Maxillofacial Radiology and Dental Research Institute, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    1999-08-15

    Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in late adult life, but its incidence in oral and maxillofacial region is extremely rare. We report a case of malignant fibrous histiocytoma which occurred in the infratemporal fossa. Conventional radiograph of this case showed an ill-defined radiolucent lesion in the alveolar bone of the right maxillary first molar area, the lateral wall of the maxillary sinus, and the ascending ramus of mandible. MRI demonstrated well defined mass of intermediate signal intensity in T1 weighted images but T2 weighted images showed two distinctive regions of different characteristics. Infratemporal portion of the lesion was of hyperintense signal but under that region, the signal intensity decreased clearly, which might mean this case composed of two different subtypes, though it couldn't be confirmed by histopathological examination. Biopsy was taken in the only soft tissue of the maxillary posterior alveolar region and confirmed the lesion as the storiform-pleomorphic type of malignant fibrous histiocytoma. Histopathological subtype was well consistent with the relatively aggressive imaging findings of that region. We expect more detailed analysis of the nature of malignant fibrous histiocytoma with improvement of the imaging modality and the identification of the relationship between diagnostic imaging and histopathologic findings.

  8. Malignant fibrous histiocytoma mimicking pulmonary embolism.

    Sleyster, T J; Heystraten, F M

    1988-01-01

    A rare case of malignant fibrous histiocytoma occurring in the pulmonary artery is reported. Such primary pulmonary artery sarcomas may have the diagnosis suggested by angiography or echocardiography; radiographically and in perfusion-ventilation scanning their usual unilateral origin (with later spread) and the persistence of the perfusion defect are among the features normally distinguishing them from thromboembolism.

  9. Malignant fibrous histiocytoma of the spleen

    Šipovac Dragana

    2014-01-01

    Full Text Available Introduction. Since the first description of primary splenic malignant fibrous histiocytoma given by Govoni et al. in 1982, there have been only 18 reported cases by the end of 2013. We herein reported a case of rare primary malignant fibrous histiocytoma of the spleen with liver metastases and unspecific general symptoms. Case Report. A 62-year-old cachectic female complained of sharp strong abdominal pain (on the pain scale 8/10 and distaste for food on admission at Primary Care Service on March 29, 2014. On physical examination, palpable painful 2 cm long tumefact in the left hypochondriac segment was found. Laboratory findings showed leukocytosis 17.9 x 109/l, erythrocyte sedimentation rate of 55 mm/h, C reactive protein 25.8. Magnetic resonance of abdomen proved secondary deposits in the right liver segment and lower pole of spleen. Positron emission tomography-computed tomography recorded a cold necrosis field in the right liver part and lobulated cystic formation of spleen. After radiological examination, splenectomy and resection of the pancreas cauda were performed. Primary malignant splenic fibrous histiocytoma with liver metastases was proved histopathologically. The patient was given three chemotherapeutic series until October 2, 2014 and she is now in good general condition. Conclusion. The possibility of primary malignant splenic fibrous histiocytoma should be considered in every case with proved intra-abdominal masses of unknown origin. Clinical and laboratory findings are unspecific. Surgical resection with histopathological evaluation is the most effective diagnostic and therapeutic procedure.

  10. Malignant fibrous histiocytoma of the abdominal wall

    Arif Aslaner; Burhan Mayir; Tuğrul Çakır; Umut Rıza Gündüz; Nurullah Bülbüller

    2015-01-01

    Malignant fibrous histiocytoma (MFH) or undifferentiated pleomorphic sarcoma is a type of malignt neoplasm that arises from any soft tissue and bone involving extremities, abdomen and retroperitoneum. MFH of the external oblique abdominis muscle is rare. Surgical resection of the mass is the treatment of choice depending on the stage of the disease and the invasion depth of the tumor. Radiotherapy, chemotherapy and immunotherapy are the other treatment methods. We present a case of a 71-year ...

  11. Postirradiation sarcoma (malignant fibrous histiocytoma) following cervix cancer

    A case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 11 years following postoperative external beam radiation therapy (7,000 rad) for carcinoma of the cervix. Reports of postirradiation malignant fibrous histiocytoma are rare, and the occurrence of this neoplasm following treatment for cervix cancer has not previously been described. The literature concerning postirradiation bone and soft tissue sarcomas is briefly reviewed, with special attention to malignant fibrous histiocytomas. (author)

  12. Primary Malignant Fibrous Histiocytoma: A Rare Case

    Anastasios Katsourakis

    2011-01-01

    Full Text Available Malignant fibrous histiocytoma (MFH of the small intestine is an extremely rare condition. It occurs most commonly in the extremities and the trunk. We report a case of a 67-year-old woman who admitted with fever, myalgia, and altered status. After thorough investigation, a tumor of the jejunum was found. The patient underwent complete surgical removal of the tumor. A diagnosis of MFN (undifferentiated high-grade pleomorphic sarcoma was made. The patient received adjuvant chemotherapy with Gemcitabine. Two years after the operation, the patient died due to recurrence of the disease. MFH of the small intestine is an extremely rare neoplasm with an aggressive biological behaviour. In this paper, pathogenesis, natural history, and treatment are reviewed.

  13. Malignant fibrous histiocytoma of the spleen: an extremely rare entity.

    Dawson, Leelavathi; Gupta, Oneal; Garg, Ketan

    2012-01-01

    Primary malignant fibrous histiocytoma (MFH) of the spleen is extremely rare. Since the first description of primary splenic MFH reported by Govoni et al in 1982, to the best of our knowledge, only twelve cases of MFH of the spleen have been reported in the literature. We herein report a rare case of primary splenic MFH in a 30-year-old Indian male who presented with abdominal pain with a history of recurrent hydatid cyst of liver and spleen. A computed tomography (CT) scan was performed and a diagnosis of splenic hydatid cyst was made. Splenectomy was done. On histopathological examination, a diagnosis of malignant mesenchymal tumor, possibly storiform variant of malignant fibrous histiocytoma, was made. On immunohistochemistry, the tumor was positive for vimentin and CD68. The post operative period was uneventful. Compared with the twelve previously cases of MFH of the spleen, our patient is the youngest case reported so far. PMID:22531528

  14. Malignant fibrous histiocytoma of the spleen: An extremely rare entity

    Leelavathi Dawson

    2012-01-01

    Full Text Available Primary malignant fibrous histiocytoma (MFH of the spleen is extremely rare. Since the first description of primary splenic MFH reported by Govoni et al in 1982, to the best of our knowledge, only twelve cases of MFH of the spleen have been reported in the literature. We herein report a rare case of primary splenic MFH in a 30-year-old Indian male who presented with abdominal pain with a history of recurrent hydatid cyst of liver and spleen. A computed tomography (CT scan was performed and a diagnosis of splenic hydatid cyst was made. Splenectomy was done. On histopathological examination, a diagnosis of malignant mesenchymal tumor, possibly storiform variant of malignant fibrous histiocytoma, was made. On immunohistochemistry, the tumor was positive for vimentin and CD68. The post operative period was uneventful. Compared with the twelve previously cases of MFH of the spleen, our patient is the youngest case reported so far.

  15. Two different types of malignant fibrous histiocytomas from pet dogs

    Do, Sun Hee; Hong, Il-Hwa; Park, Jin-Kyu; Ji, Ae-Ri; Kim, Tae-Hwan; Kwak, Dong-Mi; Jeong, Kyu-Shik

    2009-01-01

    We describe 2 cases of malignant fibrous histiocytomas (MFHs) that spontaneously developed in young pet dogs. To classify these tumors, we applied a panel of antibodies (vimentin, desmin, α-SMA, and ED1) and Azan staining for collagen. The MFHs were most consistent with osteoclast-like giant and inflammatory cell types. The first case had positive staining for ED1 and vimentin, and given the osteoclast-like giant cells, calcification sites accompanying peripheral giant cell infiltrates. The l...

  16. Malignant fibrous histiocytoma of the spleen: An extremely rare entity

    Leelavathi Dawson; Oneal Gupta; Ketan Garg

    2012-01-01

    Primary malignant fibrous histiocytoma (MFH) of the spleen is extremely rare. Since the first description of primary splenic MFH reported by Govoni et al in 1982, to the best of our knowledge, only twelve cases of MFH of the spleen have been reported in the literature. We herein report a rare case of primary splenic MFH in a 30-year-old Indian male who presented with abdominal pain with a history of recurrent hydatid cyst of liver and spleen. A computed tomography (CT) scan was performed and ...

  17. Malignant fibrous histiocytoma of the lower lip: A case report

    Pechalova Petia F

    2012-01-01

    Full Text Available Malignant fibrous histiocytoma (MFH represents the diagnosis that is still commonly used by both patients and physicians although in 2002., the World Health Organization (WHO declassified MFH as a formal diagnostic entity, renaming it as an undifferentiated pleomorphic sarcoma not specifying it further. MFH is extremely rare in the oral cavity. The aim of this article was to describe a newly diagnosed case of primary MFH in a 78-year-old male presented after 4-months history of rapidly increasing swelling of lower lip. Histopathology of the lesion showed highly malignant cell infiltration with epithelioid/spindle cell type morphology. Immunohistochemical study was positive for vimentin (++, S-100 protein (++ and negative for desmin and cytokeratin. The authors discussed the possibilities of immunohistochemical study and necessity of individual treatment plan in patients with MFH, comparing their point of view with other studies.

  18. Malignant fibrous histiocytoma presenting as hemoperitoneum mimicking hepatocellular carcinoma rupture

    2007-01-01

    Malignant fibrous histiocytoma (MFH) is a pleomorphic mesenchynal sarcoma. It is uncommonly arises primarily from the intra-peritoneal cavity. Primary peritoneal MFH with tumor bleeding and rupture is rare. We describe the imaging features of a 70-year-old patient presenting with ruptured hemorrhagic peritoneal MFH at subhepatic area, accompanied by massive hemoperitoneum,mimicking a ruptured pedunculated hepatocellular carcinoma. Computed tomography (CT) revealed a large heterogeneous enhanced subhepatic mass with adjacent liver, gallbladder and colon invasion. Tumor hemorrhage and rupture complicated with peritoneal seeding and massive bloody ascites were also detected.Angiography showed a hypervascular tumor fed by enlarged right hepatic arteries, cystic artery and omental branches of gastroepiploic artery. The patient underwent laparotomy for tumor resection, but the tumor recurred one month after operation. To our knowledge, the CT appearance of ruptured intraperitoneal MFH complicated by hemoperitoneum has not been previously described.

  19. Benign Fibrous Histiocytoma

    Pushpa Varma

    2014-01-01

    Full Text Available Fibrous histiocytomas (FHs are mesenchymal tumors that may be benign or malignant. Ocular involvement by FHs is infrequent and primarily limited to the orbit. Rarely, FHs can also involve the conjunctiva and perilimbal area. We report the case of a 38-year-old male with lid, conjunctival, and neck FHs. The diagnosis was confirmed by histopathology.

  20. An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report

    Wang Lian-Li

    2013-01-01

    Full Text Available Abstract Introduction Malignant fibrous histiocytoma is a very common subtype of soft-tissue sarcoma in middle and late adulthood. However, malignant fibrous histiocytoma of the testis is very rare in adolescents. Case presentation We report here the case of a 14-year-old Han Chinese boy, who presented with left scrotal mass lasting for 20 days along with distending pain for 5 days. A physical examination revealed a chicken egg-sized, firm, well-defined mass and unclear epididymis. A B-scan ultrasonography of the left scrotum displayed a 9.0×5.2×4.5cm medium- or low-echoic lobulated mass, which suggested a left testicular neoplasm. A fine needle aspiration cytology examination revealed that the cells obtained from the patient’s testicular neoplasm were composed of myxoid spindle, and ovoid cells with nuclear atypia and mitotic activity, and arranged in a whirlpool or storiform pattern. Under histological examination, the tumor cells were arranged in a storiform pattern, which displayed mucoid matrix degeneration, and grew invasively. Consequently, a histopathological diagnosis suggested myxofibrosarcoma (or myxoid malignant fibrous histiocytoma. Conclusions An ultrasonic examination combined with fine needle aspiration cytology should be helpful for the initial differential diagnosis of testicular malignant fibrous histiocytoma. However, the final confirmation relies on histopathological examination. To the best of our knowledge, this is the first reported case of malignant fibrous histiocytoma of the testis in an adolescent.

  1. Postirradiation malignant fibrous histiocytoma expressing cytokeratin. Implications for the immunodiagnosis of sarcomas

    Weiss, S.W.; Bratthauer, G.L.; Morris, P.A.

    1988-07-01

    A malignant fibrous histiocytoma of the sacrum complicating the course of radiation therapy for endometrial carcinoma is presented. Although the tumor fulfilled the clinical, radiologic, and histologic criteria for a postirradiation malignant fibrous histiocytoma of bone, it also expressed cytokeratin. That this immunoreactivity reflected keratin synthesis by the tumor and not an unusual pattern of cross-reactivity with another intermediate filament such as vimentin is strongly suggested by the reproducibility of the immunoreactivity utilizing both polyclonal and monoclonal antibodies and extinction of the immunoreactivity following absorption of the primary antiserum with keratin proteins. This is the first reported instance of keratin expression by a malignant fibrous histiocytoma; it indicates that sarcomas apart from synovial sarcoma and epithelioid sarcoma may sometimes express this protein.

  2. Postirradiation malignant fibrous histiocytoma expressing cytokeratin. Implications for the immunodiagnosis of sarcomas

    A malignant fibrous histiocytoma of the sacrum complicating the course of radiation therapy for endometrial carcinoma is presented. Although the tumor fulfilled the clinical, radiologic, and histologic criteria for a postirradiation malignant fibrous histiocytoma of bone, it also expressed cytokeratin. That this immunoreactivity reflected keratin synthesis by the tumor and not an unusual pattern of cross-reactivity with another intermediate filament such as vimentin is strongly suggested by the reproducibility of the immunoreactivity utilizing both polyclonal and monoclonal antibodies and extinction of the immunoreactivity following absorption of the primary antiserum with keratin proteins. This is the first reported instance of keratin expression by a malignant fibrous histiocytoma; it indicates that sarcomas apart from synovial sarcoma and epithelioid sarcoma may sometimes express this protein

  3. Clinical analysis of 10 patients with primary malignant fibrous histiocytoma of the lung

    Objective: Objective To study the treatment method and prognosis of primary malignant fibrous histiocytoma of the lung. Methods: Ten patients with primary malignant fibrous histiocytoma of the lung proved by histopathology were reviewed retrospectively. Five were treated by surgery alone, 3 by postoperative radiotherapy and 2 by postoperative chemotherapy. Results: Six of ten patients were able to survive more than 1 year. Four of the six survived more than 2 years and 3 more than 3 years. The 1-, 2-year survival rates were 60% and 40%, respectively. The relapse sites after treatment included: local recurrence (n=1); distant metastasis (n=1) and local recurrence plus distant metastasis (n=3), the interval ranging from 1 to 18 months. Conclusions: The prognosis of primary malignant fibrous histiocytoma of the lung is poor. Surgery is the main treatment method. The role of either postoperative radiation therapy or chemotherapy remains unclear. (authors)

  4. Haematoma-like primary intracranial malignant fibrous histiocytoma in a 5-year-old girl

    We present CT and MRI of an intracranial malignant fibrous histiocytoma in a 5-year-old girl with headache and vomiting. This case is unusual particular by virtue of its radiological appearances and the young age of the patient. (orig.)

  5. The CT and F-FDG PET/CT appearance of Primary renal malignant fibrous histiocytoma

    Full text: Renal malignant fibrous histiocytoma (MFH) is a rare, primary renal tumour. Imaging findings of renal MFH, including ultrasound, CT and MRI, have, however, been reported. As to the best of our knowledge 18F-FDG PETjCT imaging of renal MFH has not been previously reported, we present the CT and 18F-FDG PETjCT appearance of a pathologically proven primary renal MFH.

  6. Primary giant cell malignant fibrous histiocytoma-associated with renal calculus

    Altunkol, Adem; Savas, Murat; Ciftci, Halil; Gulum, Mehmet; Yagmur, Ismail; Bitiren, Muharrem

    2014-01-01

    Malignant fibrous histiocytomas (MFH) are the most commonly seen soft tissue sarcomas in adults. It is rarely seen in some visceral organs. Kidneys are the parenchymal organs in which MFHs are most frequently seen. More than 50 cases of primary renal MFH have been reported. Among these cases, only 1 was reported as primary giant cell subtype in association with urolithiasis. This case report is the second such case with the these characteristics.

  7. Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma.

    Coindre, Jean-Michel; Mariani, Odette; Chibon, Frédéric; Mairal, Aline; De Saint Aubain Somerhausen, Nicolas; Favre-Guillevin, Elizabeth; Bui, Nguyen Binh; Stoeckle, Eberhard; Hostein, Isabelle; Aurias, Alain

    2003-03-01

    Forty-four samples from 25 cases of retroperitoneal sarcoma initially diagnosed as malignant fibrous histiocytoma were histologically reviewed. Immunohistochemistry for mdm2 and cdk4 was performed on 20 cases. Comparative genomic hybridization was performed on 18 samples from 13 patients. Seventeen cases were reclassified as dedifferentiated liposarcoma. Twenty-one of 32 samples from these patients showed areas of well-differentiated liposarcoma, allowing the diagnosis of dedifferentiated liposarcoma. Immunohistochemistry performed in 15 of these cases showed positivity for mdm2 and cdk4. Comparative genomic hybridization analysis performed on 15 samples from 11 of these patients showed an amplification of the 12q13-15 region. Eight cases were reclassified as poorly differentiated sarcoma. Twelve samples from these patients showed no area of well-differentiated liposarcoma. Immunohistochemistry showed positivity for mdm2 and cdk4 in one of six of these patients and showed positivity for CD34 in another one. Comparative genomic hybridization analysis performed on three samples from two of these patients showed no amplification of the 12q13-15 region but showed complex profiles. This study shows that most so-called malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcoma and that a poorly differentiated sarcoma in this area should prompt extensive sampling to demonstrate a well-differentiated liposarcoma component, immunohistochemistry for mdm2 and cdk4, and if possible, a cytogenetic or a molecular biology analysis. PMID:12640106

  8. Giant cell variant of malignant fibrous histiocytoma of male breast: A rare case report

    Kamlesh Kumar Harsh; Ashok Kalwar; Akhil Kapoor; Shankar Lal Jakhar; Harvindra Singh Kumar

    2015-01-01

    Malignant fibrous histiocytoma (MFH) is the most common form of soft tissue sarcoma during middle and late adulthood in the deep connective tissue of the extremities, abdominal cavity, and retroperitoneum. However, primary breast sarcoma is a rare disease entity, comprising less than 1% of all breast malignancies. MFH of the male breast is very rare. We present a case of MFH of giant cell variant of the right breast in a 50-year-old male who presented with a painless lump. Following cytologic...

  9. Post-radiation malignant fibrous histiocytoma following treatment of breast cancer: A case report

    Post-radiation malignant fibrous histiocytoma (MFH) of the breast is extremely rare. We report a case of post-radiation MFH that presented a rapidly growing mass in a 52-year-old woman who underwent breast-conserving therapy and adjuvant whole breast irradiation 6 years ago. To the best of our knowledge, only one case of primary MFH of the female breast have been reported with sonographic findings. We analyzed the sonographic and MRI findings with correlative histopathologic features, and then confirmed with surgical excision.

  10. Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature

    Yao Dianbo

    2012-01-01

    Full Text Available Abstract Background A malignant fibrous histiocytoma is a soft tissue tumor that most commonly occurs in the extremities, but rarely involves the liver. The clinical characteristics and therapeutic experiences of primary hepatic malignant fibrous histiocytoma are still limited. Methods Two cases of primary hepatic malignant fibrous histiocytoma were analyzed retrospectively, and all the literature concerning primary hepatic malignant fibrous histiocytoma was analyzed. Results In China, a total of 76 cases had been reported, among which 50 were men, with a male to female ratio of 1.9:1. Mean age of the patients was 51.0 years old, and more than 85 percent were older than 40 years. 82.9 percent (63/76 of hepatic MFH were solitary lesions, with tumor size ranging from 2.5 to 23.5 cm (average 10.3 cm. Major clinical presentation (78.4% was abdominal pain or discomfort, accompanied with some other non-specific symptoms such as malaise, anorexia, weight loss, jaundice and fever, and small cases (14.9% were asymptomatic. Computed tomography and ultrasound usually revealed the location of lesions. The rate of pre-operative misdiagnosis was extremely high, and 14.9 percent of patients were even misdiagnosed as a benign liver cyst, liver abscess or hematoma. Integrated resection was performed among the most cases (49/68, among which only a few ones (12 cases were introduced to have no recurrence or metastasis or be still alive with no detail information provided, while among the cases with palliative operation or only a biopsy, the cases that were followed-up all died. Conclusions Hepatic malignant fibrous histiocytoma is a rare malignant mesenchymal tumor. The variable features of clinical presentations and images make the diagnosis difficult. Though the prognosis of primary hepatic malignant fibrous histiocytoma was rather poor, integrated resection might provide a few cases a good opportunity for surviving, suggesting that surgery might be an effective

  11. Malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma of the penis. A case report

    We report the case of a malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (MFH/UPS) of the penis in a 78-years-old-man who had undergone previous radical prostatectomy, external beam radiation therapy for prostatic adenocarcinoma. The mass was a 9-cm firm lesion at the base of the penis predominantly composed of malignant spindle cells arranged in sweeping fascicles and storiform pattern. The tumor cells stained for vimentin, α-smooth muscle actin, S-100, and were negative for keratin, desmin, Melan A, prostate specific antigen (PSA). Despite total penectomy, he developed a local reccurence 4 months after surgery, and died from dissemination 6 months after surgery. This is the 8th case of penile MFH/UPS. (author)

  12. A rare case report of malignant fibrous histiocytoma of male breast

    Rajshri P Damle

    2016-01-01

    Full Text Available Malignant fibrous histiocytoma (MFH is an extremely rare tumor of the breast that arises from the connective tissue of glands. Its complex and various histological patterns, adds difficulty to the diagnosis. We report a case of MFH of left breast in a 70-year-old male who presented with gradually increasing painless mass over a period of 1–2 years. Fine-needle aspiration cytology revealed malignant spindle cell lesion and wide local excision was performed without axillary lymph node dissection. Histopathological examination along with immunohistochemistry confirmed the diagnosis of MFH of left breast. To the best of our knowledge, this is the 6th case of MFH of left breast in an elderly male reported in the literature.

  13. Malignant fibrous histiocytoma of the breast. A case report and review of the literature

    The clinicopathologic features of a malignant fibrous histiocytoma arising in a female breast are presented. Seven cases have been previously reported. These may be divided into three subgroups based on history and pathologic findings. Three of the seven occurred in women without a history of other tumors or previous irradiation. One appeared with a cystosarcoma phyllodes, and three arose following radiation for carcinoma of the breast. The patient in this study had received no radiation. Treatment has been based on surgical resection; the roles of chemotherapy and radiation are uncertain. Although resection alone in the first subgroup has lead to no reported mortality, the small number of cases and the relatively short follow-up does not allow a meaningful assessment of the prognosis in this disease

  14. A case of primary malignant fibrous histiocytoma of the pancreas with liver metastasis

    Wenlong Zhai; Jianwen Ye; Zhiwei Liang; Chuang Zhou; Longshuan Zhao

    2015-01-01

    Malignant fibrous histiocytoma (MFH) is one of most common types of soft-tissue sarcoma. However, it accounts for less than 1% of al human cancer types. In addition, primary MFH of the pancreas is very rare. Herein, we report of a 37-year-old man who presented with a pancreatic mass and did not show any specific symptoms. Pre-contrast computed tomography (CT) showed a heterogeneous, liquid-filed necrotic mass in the uncinate lobe of the pancreas. Contrast-enhanced CT showed a mild enhancement of solid components and the pancreaticoduodenal artery across the mass. The patient underwent a pancreatico-duodenectomy, ethanol ablation of the liver lesions, and chemotherapy with 4 cycles of ifosfamide and doxorubicin. The tumor recurred in the liver, but not in the pancreas, after 8 months.

  15. Malignant fibrous histiocytoma of the urinary bladder as a post-radiation secondary cancer: a case report

    Nimmanon Thirayost

    2011-11-01

    Full Text Available Abstract Introduction Malignant fibrous histiocytomas have been periodically reported as the primary tumor in various organs including the urinary bladder, and is the second most frequent sarcoma of the urinary tract in adults. This report discusses a case of the well established diagnosis of a malignant fibrous histiocytoma of the bladder occurring as a post-radiation cancer after the treatment of a cervical carcinoma. Our findings support those of many previous studies and make the view of the nature of the disease clearer. Case presentation We report the case of a 54-year-old Thai woman who had been treated with radiation therapy for cervical cancer, who presented to our facility with urinary incontinence. Initially, our patient was diagnosed as having a high-grade urothelial carcinoma. Subsequent radical surgery rendered the final pathological diagnosis, confirmed histologically and immunohistochemically as malignant fibrous histiocytoma, with clinical and pathological staging of T4b N0 M0. Adjuvant chemotherapy was provided for our patient. Conclusions This type of malignancy is very aggressive and easily misdiagnosed due to its rarity. Therefore, in a patient with a prior history of irradiation in the pelvic area, this should be considered as a differential diagnosis to ensure early correct diagnosis and treatment.

  16. The RB1 gene is the target of chromosome 13 deletions in malignant fibrous histiocytoma.

    Chibon, F; Mairal, A; Fréneaux, P; Terrier, P; Coindre, J M; Sastre, X; Aurias, A

    2000-11-15

    Forty-four malignant fibrous histiocytomas (MFHs) were studied by comparative genomic hybridization. Among the observed imbalances, losses of the 13q14-q21 region were observed in almost all tumors (78%), suggesting that a gene localized in this region could act as a tumor suppressor gene and that its inactivation could be relevant for MFH oncogenesis and/or progression. We determined by CA repeat analyses a consensus region of deletion focusing on the RB1 region. The RB1 gene was then analyzed by protein truncation test, direct sequencing, fluorescence in situ hybridization, Southern blotting, and immunohistochemistry. RB1 mutations and/or homozygous deletions were found in 7 of the 34 tumors analyzed (20%). Among the 35 tumors with comparative genomic hybridization imbalances analyzed by immunohistochemistry, 30 (86%) did not exhibit significant nuclear labeling. The high correlation between chromosome 13 losses and absence of RB1 protein expression and the mutations detected strongly suggest that RB1 gene inactivation is a pivotal event in MFH oncogenesis. Moreover, the observation of a high incidence of MFH in patients previously treated for hereditary retinoblastoma fits well this hypothesis. PMID:11103795

  17. Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report

    Park, Hye Young; Seo, Jung Wook; Lee, Byung Hoon; Lee, Ji Young; Kim, Su Young; Cha, Soon Joo; Kim, Yong Hoon; Hwang, Yoon Joon; Kim, You Sung [Dept. of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang (Korea, Republic of)

    2013-03-15

    A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

  18. Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances.

    Idbaih, Ahmed; Coindre, Jean-Michel; Derré, Josette; Mariani, Odette; Terrier, Philippe; Ranchère, Dominique; Mairal, Aline; Aurias, Alain

    2005-02-01

    Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma. Nevertheless, the validity of this heterogeneous pathological entity has been recurrently questioned by pathologists. Recently, analyses by comparative genomic hybridization (CGH) of a large series of MFHs suggested that MFHs consist of morphologic modulation of other poorly differentiated sarcomas like leiomyosarcomas (LMS) or dedifferentiated liposarcomas (DLPS). We report here an analysis by CGH of 22 myxoid MFHs (mMFH), one of the five histological subtypes of MFH, and of nine pleomorphic liposarcomas (pLPS), a rare poorly differentiated LPS. The chromosome imbalances encountered in the series of mMFH were very similar to those observed in the series of pLPS studied in the laboratory and in the series of 14 pLPS published in the literature. The most frequent gains involved chromosome subregions: pericentromeric regions of 1, 5p, 19p, 19q and 20q. Losses found in the chromosomal arms 1q, 2q, 3p, 4q, 10q, 11q and 13q were also recurrent. The use of a clustering software did not separate the two pathological groups (mMFH and pLPS) on the basis of genomic data. Moreover, pLPS-mMFH represented, according to the clustering software results, an entity clearly distinguished from other soft tissue sarcomas, LMS in particular, with which they share common genetic aberrations. Additional studies are needed to identify genes targeted by these genomic aberrations, and implicated in the oncogenesis of these tumor subtypes. The characterization of common gene alterations in both tumor groups would suggest a closer relationship between these two types of soft tissue sarcomas. PMID:15702084

  19. Benign fibrous histiocytoma of the lumbar vertebrae

    Demiralp, Bahtiyar; Oguz, Erbil; Sehirlioglu, Ali [Gulhane Military Medical Academy, Department of Orthopedics and Traumatology, Ankara (Turkey); Kose, Ozkan [Diyarbakir Education and Research Hospital, Department of Orthopedics and Traumatology, Diyarbakir (Turkey); Ataslar Serhat Evleri, Diclekent Bulvari, Diyarbakir (Turkey); Sanal, Tuba [Gulhane Military Medical Academy, Department of Radiology, Ankara (Turkey); Ozcan, Ayhan [Gulhane Military Medical Academy, Department of Pathology, Ankara (Turkey)

    2009-02-15

    Benign fibrous histiocytoma is an extremely rare spinal tumor with ten reported cases in the literature. Benign fibrous histiocytoma constitutes a diagnostic challenge because it shares common clinical symptoms, radiological characteristics, and histological features with other benign lesions involving the spine. We present a case of benign fibrous histiocytoma of the lumbar spine and discuss its differential diagnosis and management. (orig.)

  20. The use of clustering software for the classification of comparative genomic hybridization data. an analysis of 109 malignant fibrous histiocytomas.

    Chibon, Frédéric; Mariani, Odette; Mairal, Aline; Derré, Josette; Coindre, Jean-Michel; Terrier, Philippe; Lagacé, Réal; Sastre, Xavier; Aurias, Alain

    2003-02-01

    Malignant fibrous histiocytoma (MFH) is considered the most frequent soft-tissue sarcoma of late adult life. Nevertheless, the validity of this entity has been recurrently questioned by pathologists. Preliminary analyses by comparative genomic hybridization (CGH) of series of MFH have suggested that this tumor group is heterogeneous at the genomic level, and that at least two main genetic subgroups exist. We report an analysis by CGH of a large series of 109 MFH and on the use of clustering software for an objective classification of these tumors. We confirm our preliminary CGH results and demonstrate that two main clusters of tumors are present in the series analyzed. PMID:12581902

  1. Malignant fibrous histiocytoma of the deep peri-articular tissue of the stifle in a dog : case report

    M.J. Booth

    1998-07-01

    Full Text Available A Belgian shepherd dog aged 4 years and 9 months was presented with acute onset of non-weight bearing lameness and stifle effusion of the left hind limb, caused by the deep form of a malignant fibrous histiocytoma originating in the deep musculature and fascia surrounding the stifle joint. The tumour progressed rapidly in the tissues along the femoral diaphysis with marked periosteal new bone formation. Cytology of a stifle joint aspirate revealed numerous large polygonal neoplastic cells with considerable anisocytosis and anisokaryosis. These cells were present in clusters, with cytoplasmic projections between the cells, but occasionally also occurred singly. Several cells contained multiple cytoplasmic vacuoles and occasional giant cells were also encountered. Adequate tumour-free margins were not possible with radical limb amputation and the dog was euthanased. Macroscopically the tumour appeared as an extensive pale tan, firm mass with scattered small haemorrhages and foci of yellow discolouration. Histologically the tumour consisted of dense neoplastic expanses or multiple nodules, composed of spindle-shaped fibroblastic cells, polygonal histiocytic cells or cell clusters and scattered giant cells with 2-3 nuclei. The polygonal neoplastic cells were frequently present around and invading lymphatics and blood vessels, causing neoplastic emboli. This is the 1st report of the clinical behaviour, radiography and cytology of the deep form of malignant fibrous histiocytoma in the dog.

  2. An adult patient who developed malignant fibrous histiocytoma 9 years after radiation therapy for childhood acute lymphoblastic leukemia

    Kato, Yasuhiro [National Hiroshima Hospital, Higashi-Hiroshima (Japan); Ohno, Norioki; Horikawa, Yoko; Nishimura, Shin-ichiro; Ueda, Kazuhiro; Shimose, Shoji [Hiroshima Univ. (Japan). School of Medicine

    2002-12-01

    A 24-year-old Japanese man with a history of acute lymphoblastic leukemia, which occurred during childhood, developed malignant fibrous histiocytoma of his left knee. His past history revealed that he had undergone leukemic blast cell invasion of the left knee and subsequent radiation therapy 9 years ago. The total radiation doses for the upper part of the left tibia and the lower part of the left femur were 60 Gy and 40 Gy, respectively. Neither distant metastasis nor a relapse of leukemia occurred. A curative resection of the left femur with a noninvasive margin was performed. Adjuvant chemotherapy including high-dose methotrexate was given successfully before and after surgery; this was followed by relapse-free survival for 3 years. The nature of postirradiation malignant fibrous histiocytoma is highly aggressive. When a patient complains of persistent symptoms in a previously irradiated field, the possibility of this tumor must be taken into account. The importance of early diagnosis cannot be over-emphasized. (author)

  3. Diaphyseal medullary stenosis (sclerosis) with bone malignancy (malignant fibrous histiocytoma): hardcastle syndrome

    Hardcastle syndrome is a rare, autosomally dominant inherited skeletal dysplasia, characterized by diaphyseal sclerosis, medullary stenosis, pathological fractures, bony infarction, and malignant transformation. A 19-year-old proband is presented and discussed, adding a fourth family to the world literature. Radiographic screening of family members is suggested from puberty onward. Thallium scanning is proposed as a more tumor-sensitive screening agent in affected individuals. (orig.). With 2 figs

  4. Accumulation of MRI contrast agents in malignant fibrous histiocytoma for gadolinium neutron capture therapy

    Fujimoto, T. [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan)], E-mail: fujitaku@hp.pref.hyogo.jp; Ichikawa, H. [Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586 (Japan); Akisue, T. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Fujita, I. [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan); Kishimoto, K.; Hara, H. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Imabori, M. [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan); Kawamitsu, H. [Department of Radiology, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Sharma, P.; Brown, S.C.; Moudgil, B.M. [Particle Engineering Research Center, University of Florida, Gainesville, FL32611 (United States); Fujii, M. [Department of Radiology, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Yamamoto, T. [Department of Orthopaedic Surgery, Kagawa University, Kagawa 761-0793 (Japan); Kurosaka, M. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Fukumori, Y. [Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586 (Japan)

    2009-07-15

    Neutron-capture therapy with gadolinium (Gd-NCT) has therapeutic potential, especially that gadolinium is generally used as a contrast medium in magnetic resonance imaging (MRI). The accumulation of gadolinium in a human sarcoma cell line, malignant fibrosis histiocytoma (MFH) Nara-H, was visualized by the MRI system. The commercially available MRI contrast medium Gd-DTPA (Magnevist, dimeglumine gadopentetate aqueous solution) and the biodegradable and highly gadopentetic acid (Gd-DTPA)-loaded chitosan nanoparticles (Gd-nanoCPs) were prepared as MRI contrast agents. The MFH cells were cultured and collected into three falcon tubes that were set into the 3-tesra MRI system to acquire signal intensities from each pellet by the spin echo method, and the longitudinal relaxation time (T1) was calculated. The amount of Gd in the sample was measured by inductively coupled plasma atomic emission spectrography (ICP-AES). The accumulation of gadolinium in cells treated with Gd-nanoCPs was larger than that in cells treated with Gd-DTPA. In contrast, and compared with the control, Gd-DTPA was more effective than Gd-nanoCPs in reducing T1, suggesting that the larger accumulation exerted the adverse effect of lowering the enhancement of MRI. Further studies are warranted to gain insight into the therapeutic potential of Gd-NCT.

  5. Oral benign fibrous histiocytoma: two case reports

    Menditti, Dardo; Laino, Luigi; Mezzogiorno, Antonio; Sava, Sara; Bianchi, Alexander; Caruso, Giovanni; Di Maio, Luigi; Baldi, Alfonso

    2009-01-01

    Fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body. The involvement of the oral cavity is rare. We report two cases of benign fibrous histiocytoma that localized in the oral cavity. The clinical and histological features of the lesion are reported. Finally, a literature revision of this pathology at the level of the oral cavity is reported.

  6. 99Tcm-MDP whole body bone scan for the ancillary diagnosis of malignant fibrous histiocytoma of bone

    Objective: To investigate the usefulness of 99Tcm-MDP whole body bone scan in bone malignant fibrous histiocytoma (BMFH). Methods: Fifteen patients (11 males, 4 females, age ranged from 23 to 60 years,average age (50.4±12.8) years) who had documented BMFH and underwent 99Tcm-MDP whole body bone scan were retrospectively analyzed. The appearance of increased uptake, decreased uptake or defect in radioactivity on bone was considered as positive. The typical scintigraphic manifestations of BMFH were summarized and compared to other radiological imaging data. Results: All 15 patients showed positive results. The lesions involved femoral in 10 cases(66.7%),46.7%(7/15) of which was distal femur. The lesions also involved sacrum, tibia, humerus, radius each in 1 case and multiple lesions in 1 case. Among 27 lesions found, 63.0% (17/27) showed strong increased radioactivity together with reduced or defect area and 37.0% (10/27) showed strong increased radioactivity only. X-ray found 20 lesions. Twelve cases underwent CT and 7 cases underwent MRI. Abnormal spots showed on CT and MRI were also positive on the whole body bone scan. Conclusions: The most common site of BMFH is femur, especially distal femur. BMFH lesions are presented as strong increased radioactivity together with sparse and defect area on bone scan. The whole body bone scan may be an auxiliary examination to evaluate whether there are multiple bone lesions and bone metastasis. (authors)

  7. Transcutaneous application of carbon dioxide (CO2 induces mitochondrial apoptosis in human malignant fibrous histiocytoma in vivo.

    Yasuo Onishi

    Full Text Available Mitochondria play an essential role in cellular energy metabolism and apoptosis. Previous studies have demonstrated that decreased mitochondrial biogenesis is associated with cancer progression. In mitochondrial biogenesis, peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α regulates the activities of multiple nuclear receptors and transcription factors involved in mitochondrial proliferation. Previously, we showed that overexpression of PGC-1α leads to mitochondrial proliferation and induces apoptosis in human malignant fibrous histiocytoma (MFH cells in vitro. We also demonstrated that transcutaneous application of carbon dioxide (CO(2 to rat skeletal muscle induces PGC-1α expression and causes an increase in mitochondrial proliferation. In this study, we utilized a murine model of human MFH to determine the effect of transcutaneous CO(2 exposure on PGC-1α expression, mitochondrial proliferation and cellular apoptosis. PGC-1α expression was evaluated by quantitative real-time PCR, while mitochondrial proliferation was assessed by immunofluorescence staining and the relative copy number of mitochondrial DNA (mtDNA was assessed by real-time PCR. Immunofluorescence staining and DNA fragmentation assays were used to examine mitochondrial apoptosis. We also evaluated the expression of mitochondrial apoptosis related proteins, such as caspases, cytochorome c and Bax, by immunoblot analysis. We show that transcutaneous application of CO(2 induces PGC-1α expression, and increases mitochondrial proliferation and apoptosis of tumor cells, significantly reducing tumor volume. Proteins involved in the mitochondrial apoptotic cascade, including caspase 3 and caspase 9, were elevated in CO(2 treated tumors compared to control. We also observed an enrichment of cytochrome c in the cytoplasmic fraction and Bax protein in the mitochondrial fraction of CO(2 treated tumors, highlighting the involvement of mitochondria in apoptosis

  8. Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report

    Bohn Olga L; de León Eric; Lezama Oscar; Rios-Luna Nina P; Sánchez-Sosa Sergio; Llombart-Bosch Antonio

    2012-01-01

    Abstract Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses. The patient had no other primary malignant neoplasm, thus excluding a metastatic lesion. G...

  9. Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report

    Bohn Olga L

    2012-11-01

    Full Text Available Abstract Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses. The patient had no other primary malignant neoplasm, thus excluding a metastatic lesion. Gross examination revealed a thickened right pulmonary artery and a necrotic and hemorrhagic tumor, filling and occluding the vascular lumen. The mass extended distally, within the pulmonary vasculature of the right lung. Microscopically, an intravascular undifferentiated tumor was identified. The tumor cells showed expression for vascular markers VEGFR, VEGFR3, PDGFRa, FGF, Ulex europaeus, FVIII, FLI-1, CD31 and CD34; p53 was overexpressed and Ki67 proliferative rate was increased. Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome. Virtual slide The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2315906377648045.

  10. Establishment of a human malignant fibrous histiocytoma cell line, COMA. Characterization By conventional cytogenetics, comparative genomic hybridization, and multiplex fluorescence In situ hybridization.

    Mairal, A; Chibon, F; Rousselet, A; Couturier, J; Terrier, P; Aurias, A

    2000-09-01

    The human COMA cell line has been established from a storiform pleomorphic malignant fibrous histiocytoma (MFH). As expected for this tumor type, a very complex karyotype was observed after R-banding analysis. An extensive analysis by 24-color painting, comparative genomic hybridization (CGH), and fluorescence in situ hybridization (FISH) was performed. Twelve complex marker chromosomes recurrently observed were clearly identified; among them, three were systematically present in all analyzed metaphases. Amplifications detected by CGH were refined by FISH with probes specific for various candidate loci. A significant aneuploidy and numerous micronuclei were observed, which could be related to the anomalies of centriole numbers detected in a proportion of cells. Such an analysis, performed on a series of MFH cell lines, would allow the delineation of the genomic alterations specific for the oncogenesis or progression of this complex tumor type or both. PMID:11063793

  11. Loss of chromosome 13 is the most frequent genomic imbalance in malignant fibrous histiocytomas. A comparative genomic hybridization analysis of a series of 30 cases.

    Mairal, A; Terrier, P; Chibon, F; Sastre, X; Lecesne, A; Aurias, A

    1999-06-01

    Regional chromosome localizations of DNA copy number imbalances were studied by comparative genomic hybridization in 30 malignant fibrous histiocytomas: 13 primary tumors (2 myxoid, 9 storiform pleomorphic, and 2 with more undifferentiated phenotype) and 17 local recurrences (2 myxoid, 11 storiform pleomorphic, and 4 with more undifferentiated phenotype). Abnormal comparative genomic hybridization (CGH) profiles were observed in 25 tumors (83%). The most frequent gains (ratio > 1.2) corresponded, by order of frequency, to entire Xp, and bands 1q21, 19q13.1, 19p13, 5p13-p14, 1p31, 17p, 18p, 20q, 1p35, 17q23, and 22q12. High levels of gains (ratio > 1.5) were recurrently detected for Xp (10 cases), and in bands 1q21-q22 (8 cases), 3q27 (4 cases), 5p13-p14 (3 cases), 13q32-q34 (3 cases), 15q22-q26 (3 cases), and 17p11-p12 (3 cases). Losses of 13q12-q14 or 13q21 were observed in a large proportion of tumors (17 cases), suggesting that a gene localized in this region could act as a tumor suppressor gene. Losses of 11q23, 2q32, 11p13, 10p, 1q4, 9p2, 16q12, 4q3, 10q25, 3p23, 2p24, and 12p were also recurrently observed. Taken together, these results provide an overview of chromosome imbalances present in MFH, which could be of use for diagnostic purposes. They point to various chromosome regions which may harbor genes important for malignant fibrous histiocytomas (MFH) oncogenesis and progression. PMID:10347550

  12. Histiocitoma fibroso maligno de orofaringe: Resección y reconstrucción con colgajo fasciocutáneo radial Malignant oropharyngeal fibrous histiocytoma: Resection and radial reconstruction with fasciocutaneous flap

    L. García Monleón

    2008-04-01

    Full Text Available El histiocitoma fibroso maligno se reconoce como el sarcoma de tejidos blandos más frecuente de la edad adulta, aunque su localización en faringe no es usual habiéndose recogido en la literatura científica tan solo 6 casos en esta localización. Presentamos el caso de un paciente con un histiocitoma fibroso maligno en orofaringe de gran tamaño, al que se le realizó una resección con amplios márgenes y la reconstrucción del defecto con un colgajo fasciocutáneo radial. Discutiremos a raíz del caso la epidemiología, manifestaciones clínicas, incidencia de metástasis, histopatología, factores pronósticos y tratamiento de este tipo de tumores.Malignant fibrous histiocytoma is recognized as the most common soft-tissue sarcoma in adults, although its location in the pharynx is unusual. Only 6 cases of the pharynx have been reported in the scientific literature. We report the case of a patient with a large malignant fibrous histiocytoma in the oropharynx. The tumor was resected with generous margins and the defect was reconstructed with a radial fasciocutaneous flap. The epidemiology, clinical manifestations, incidence of metastases, histopathology, prognostic factors and treatment of malignant fibrous histiocytoma are discussed in relation to this case.

  13. ASK1 (MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14-q15 and 6q23 amplifications.

    Chibon, Frédéric; Mariani, Odette; Derré, Josette; Mairal, Aline; Coindre, Jean-Michel; Guillou, Louis; Sastre, Xavier; Pédeutour, Florence; Aurias, Alain

    2004-05-01

    Malignant fibrous histiocytomas (MFHs) are aggressive tumors without any definable line of differentiation. We recently demonstrated that about 20% of them are characterized by high-level amplifications of the 12q14-q15 chromosome region, associated with either 1p32 or 6q23 band amplification. This genetic finding, very similar to that in well-differentiated liposarcomas, strongly suggests that these tumors actually correspond to undifferentiated liposarcomas. It also suggests that the lack of differentiation could be the consequence of amplification of target genes localized in the 1p32 or 6q23 bands. We report here the characterization by array CGH of the 6q23 minimal region of amplification. Our findings demonstrate that amplification and overexpression of ASK1 (MAP3K5), a gene localized in the 6q23 band and encoding a mitogen-activated protein kinase kinase kinase of the JNK-MAPK signaling pathway, could inhibit the adipocytic differentiation process of the tumor cells. Treatment of a cell line with specific inhibitors of ASK1 protein resulted in the bypass of the differentiation block and induction of a strong adipocytic differentiation. These observations indicate that ASK1 is a target for new therapeutic management of these aggressive tumors. PMID:15034865

  14. Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization

    Isayama Teruto

    2010-11-01

    Full Text Available Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluorescence in situ hybridization (M-FISH, Urovysion™ FISH, and comparative genomic hybridization (CGH for the characterization of chromosomal aberrations. FU-MFH-2 cells were spindle or polygonal in shape with oval nuclei, and were successfully maintained in vitro for over 80 passages. The histological features of heterotransplanted tumors in severe combined immunodeficiency mice were essentially the same as those of the original tumor. Cytogenetic and M-FISH analyses displayed a hypotriploid karyotype with numerous structural aberrations. Urovysion™ FISH revealed a homozygous deletion of the p16INK4A locus on chromosome band 9p21. CGH analysis showed a high-level amplification of 9q31-q34, gains of 1p12-p34.3, 2p21, 2q11.2-q21, 3p, 4p, 6q22-qter, 8p11.2, 8q11.2-q21.1, 9q21-qter, 11q13, 12q24, 15q21-qter, 16p13, 17, 20, and X, and losses of 1q43-qter, 4q32-qter, 5q14-q23, 7q32-qter, 8p21-pter, 8q23, 9p21-pter, 10p11.2-p13, and 10q11.2-q22. Conclusion The FU-MFH-2 cell line will be a particularly useful model for studying molecular pathogenesis of human pleomorphic MFH.

  15. Angiomatoid fibrous histiocytoma: novel MR imaging findings

    To describe novel MR imaging features, and clinical characteristics of soft tissue angiomatoid fibrous histiocytoma (AFH) at presentation, local recurrence, and metastases. We described the MRI findings of six cases of histologically proven AFH. Pathologic findings, clinical presentation, and outcome were reviewed. Lesions were primarily cystic. At initial presentation, tumors were surrounded by low signal intensity fibrous pseudocapsule. High signal intensity consistent with the lymphoplasmacytic infiltrate was seen in T2-weighted and post-contrast images as a rim over the hypointense pseudocapsule (double rim sign). High signal intensity infiltrating tumoral cords extended into adjacent tissues, through pseudocapsular defects on T2-weighted and post-contrast images. The cystic component and tumor cell nodularity were demonstrated at post-contrast images. Clinically, lesions were often thought to be benign, underwent marginal resection, developed local recurrence, and one developed second recurrence consisting of metastases. Recurrent tumors appeared as multiple masses, misinterpreted as post-surgical changes. An intramuscular recurrence demonstrated double rim and infiltrating margin. A predominantly well-circumscribed, primarily cystic mass with double-rim and marginal infiltration on MRI suggests the possibility of AFH, in particular in child or young adult. Inclusion of these novel observations in AFH differential diagnosis may have a significant impact on treatment and prevention of recurrence. (orig.)

  16. Angiomatoid fibrous histiocytoma: novel MR imaging findings

    Martinez, Salutario J.; Vinson, Emily N. [Duke University Medical Center, Department of Radiology, Durham, NC (United States); Moreno, Courtney Coursey [Emory University School of Medicine, Department of Radiology and Imaging Sciences, Atlanta, GA (United States); Dodd, Leslie G. [University of North Carolina School of Medicine, Department of Pathology and Laboratory Medicine, Chapel Hill, NC (United States); Brigman, Brian E. [Duke University Medical Center, Department of Orthopedic Surgery, Durham, NC (United States)

    2016-05-15

    To describe novel MR imaging features, and clinical characteristics of soft tissue angiomatoid fibrous histiocytoma (AFH) at presentation, local recurrence, and metastases. We described the MRI findings of six cases of histologically proven AFH. Pathologic findings, clinical presentation, and outcome were reviewed. Lesions were primarily cystic. At initial presentation, tumors were surrounded by low signal intensity fibrous pseudocapsule. High signal intensity consistent with the lymphoplasmacytic infiltrate was seen in T2-weighted and post-contrast images as a rim over the hypointense pseudocapsule (double rim sign). High signal intensity infiltrating tumoral cords extended into adjacent tissues, through pseudocapsular defects on T2-weighted and post-contrast images. The cystic component and tumor cell nodularity were demonstrated at post-contrast images. Clinically, lesions were often thought to be benign, underwent marginal resection, developed local recurrence, and one developed second recurrence consisting of metastases. Recurrent tumors appeared as multiple masses, misinterpreted as post-surgical changes. An intramuscular recurrence demonstrated double rim and infiltrating margin. A predominantly well-circumscribed, primarily cystic mass with double-rim and marginal infiltration on MRI suggests the possibility of AFH, in particular in child or young adult. Inclusion of these novel observations in AFH differential diagnosis may have a significant impact on treatment and prevention of recurrence. (orig.)

  17. Leiomyosarcomas and most malignant fibrous histiocytomas share very similar comparative genomic hybridization imbalances: an analysis of a series of 27 leiomyosarcomas.

    Derré, J; Lagacé, R; Nicolas, A; Mairal, A; Chibon, F; Coindre, J M; Terrier, P; Sastre, X; Aurias, A

    2001-02-01

    Twenty-seven tumor samples with a diagnosis of leiomyosarcomas (LMS) were characterized by comparative genomic hybridization. The results were compared with immunohistochemical analysis of the smooth muscle profile of the tumors and expression of the RB1 gene protein. The comparative genomic hybridization profiles suggested that 7 of the 27 tumors might have been misclassified. High levels of DNA amplification were detected in 20 different small regions and recurrently involved bands 1p34, q21, 12q13-15, 17p, and 22q. Most recurrent simple gains were noted at sites such as 1p3, 1q21, 15q12-15, 16p, 17p and 17q, 19, 20q, 22q, and Xp. Significant losses of chromosome 13 were detected in 19 of the 27 tumors with a putative common region of loss in bands 13q14-21. Losses of chromosomes 1q, 2p and 2q, 4q, 9p, 10p and 10q, 11p and 11q23, and 16q were also highly recurrent. A comparative analysis between the most frequent genomic imbalances observed in this study of LMS and the genomic imbalances observed in a large proportion of malignant fibrous histiocytomas (MFH) from a previous study demonstrated that both types of tumors had similar recurrent imbalances. Although MFH were once thought to be a separate member of the soft tissue sarcoma family, our observations support the hypothesis that MFH are a morphologic modulation in the tumoral progression of other sarcomas, particularly LMS. PMID:11232643

  18. 腹部原发性恶性纤维组织细胞瘤的CT表现%CT appearances of abdominal primary malignant fibrous histiocytoma

    祁佩红; 史大鹏; 郑红伟; 尚英杰; 薛鹏; 陈勇

    2016-01-01

    Objective To investigate CT appearances of abdominal primary malignant fibrous histiocytoma(MFH).Methods The CT characteristics,clinical features and pathological data of 1 7 patients with MFH proved pathologically were analyzed retrospectively. Results The lesions located in retroperitoneum were 6,in liver were 5,in kidney were 2,in superior mesentery was 1,in greater omentum was 1,in stomach was 1,in ileum was 1.The lesions are oval shape,lobulated,nodule shape,and the size of these lesions were large. 2 cases of MFH located in gastrointestinal tract were slightly low density,and the remaining were uneven high density due to necro-sis.In CT contrast enhanced scan,the solid portion and internal divisions showed progressive or continuous enhancement,and the nec-rosis were not enhanced in MFH located in the retroperitoneum,the greater omentum,the superior mesentery and the liver.MFH in kidney was poorly circumscribed and showed mild progressive enhancement lower than normal renal parenchyma.The stomach and ileum lesions showed uniform and continuous enhancement with normal gastrointestinal mucosa in corresponding parts.Conclusion Imaging features of retroperitoneal MFH were the same as those of interstitial tumors,and most tumors showed features of progres-sive and persistent enhancement,but have different imaging appearances with the malignant lesions in corresponding parts.%目的:探讨腹部原发性恶性纤维组织细胞瘤(MFH)的 CT 表现。方法回顾性分析经手术病理证实的17例腹部原发性 MFH 的 CT 表现及临床病理资料。结果腹膜后6例,肝脏5例,肾脏2例,肠系膜1例,大网膜1例,胃1例,回肠1例。肿块呈椭圆形、分叶状、结节形,体积较大。除2例胃肠道 MFH 呈均匀稍低密度影外,余病灶为稍低密度影内夹杂更低密度坏死区。增强后,腹膜后、大网膜、肠系膜及肝脏 MFH 多表现为实性成分、内部分隔呈渐进性或持续性强化,坏死部

  19. Imaging features of Benign fibrous histiocytoma of bone

    Objective: To evaluate the imaging features of benign fibrous histiocytoma (BFH). Methods: Imaging data were retrospectively collected and reviewed in 11 patients with pathologically proved BFH. Of the 11 patients, X-ray was performed in all patients,MR scans in 6 patients, and CT scans in 4 patients. Results: All lesions detected were a solitary lesion.The distribution of BFH was in the tibia (n=5), femur (n=3), fibula (n=1), sacrum (n=1), and thoracic vertebrae (n=1). X-ray features included eccentric osteolytic lesions in 7 patients and centric in 2 patients, with clear boundary and thinning of the cortex, and 7 patients with varying degrees of ossified border were found. CT scan shows bone destruction with density similar to soft tissue. The majority of lesions (n=3) were observed in the expanding shell of bone, 2 patients in the tibia and 1 patient in the thoracic lesions with cortical bone perforation. The thoracic lesion as soft tissue mass was detected. All of the lesions detected in CT showed no periosteal reaction. In patients with MR images, hypo to isointense signal intensity on T1WI and hyperintense signal intensity on T2WI was found. All lesions on post-contrast T1WI were detected with homogeneous or heterogeneous lesion with moderate or significant enhancement. Conclusion: Imaging features were typical for MFH which is useful tool helping correct diagnosis of MFH. (authors)

  20. Deep benign fibrous histiocytoma: computed tomography and histology findings; Histiocitoma fibroso benigno profundo: achados na tomografia computadorizada e histologia

    Farage, Luciano; Castro, Mario Augusto Padula; Macedo, Tulio Augusto Alves [Uberlandia Univ., MG (Brazil). Hospital das Clinicas. Setor de Radiologia; Salomao, Eliana Chaves; Machado, Tania Alcantara; Souza, Lincoln Pereira de; Freitas, Luiz de Oliveira [Uberlandia Univ., MG (Brazil). Faculdade de Medicina. Dept. de Clinica Medica

    2005-04-01

    We present the computed tomography images of an 83-year-old male patient with a deep benign fibrous histiocytoma at the lateral aspect of the left leg. Computed tomography images showed a well-defined mass with marked peripheral enhancement by iodinated contrast medium. Only few reports of this rare soft tissue tumor can be found in the literature. (author)

  1. Fibrohistiocitoma benigno ósseo na coluna lombar Benign fibrous histiocytoma of the lumbar spine

    Osmar Avanzi

    2005-01-01

    Full Text Available CONTEXTO: O fibrohistiocitoma benigno intra-ósseo é uma neoplasia rara, caracterizada por proliferação fibroblástica e fibras colágenas. A dor na região lombar é uma queixa freqüente em muitos pacientes, mas, na maioria das vezes está relacionada com causa muscular ou degenerativa. RELATO DE CASO: Relata-se aqui o caso de um paciente com diagnóstico de fibrohistiocitoma benigno ósseo na coluna lombar que apresentava queixa de lombalgia há cinco meses antes do diagnóstico. Foi submetida à biópsia aberta transpedicular na quarta vértebra lombar ,e, posteriormente realizada curetagem da lesão via anterior retroperitonial e artrodese vertebral de L3-L5 com enxerto de fíbula. CONCLUSÃO: Apesar de raro, o fibrohistiocitoma benigno intra-ósseo deve ser uma das hipóteses quando observamos uma lesão primária na coluna vertebral.CONTEXT: Benign intraosseous fibrous histiocytoma is a rare neoplasia, characterized by fibroblastic and collagenous fiber proliferation. Pain in the lumbar region is a frequent complaint in many patients, but most of times it is associated to muscular or degenerative causes. CASE REPORT: Here we report a case of a patient diagnosed with benign bone fibrous histiocytoma in the lumbar spine who complained of lumbar pain dating five months prior to diagnosis. The patient was submitted to open transpedicular biopsy in the forth lumbar vertebra, and subsequently, lesion curettage was performed via anterior retroperitoneal and L3-L5 vertebral arthrodesis using a fibular graft. CONCLUSION: Although rare, benign intraosseous fibrohistiocytoma should be taken into consideration when a primary lesion is observed in the spine.

  2. A Case of Cellular Fibrous Histiocytoma on the Right Elbow with Repeated Relapse within a Short Period

    Kanako Tsunoda

    2015-01-01

    Full Text Available Cellular fibrous histiocytoma, a variant of fibrous histiocytoma, is a designation used for lesions showing increased cellularity with a fascicular growth pattern and frequent extension into the subcutis. Here we describe a case of cellular fibrous histiocytoma showing repeated recurrence in a 36-year-old woman who initially presented with a 2-cm cutaneous tumor on her right elbow. Histopathologically, the first resected specimen demonstrated irregularly arranged collagen fibers mixed with scattered proliferating plump to spindle-shaped fibrohistiocytes. However, examination of the resected specimens obtained after recurrence showed that the cellularity had increased, the spindle-shaped cells showing monomorphic proliferation with a fascicular and storiform growth pattern extending into the subcutis, as well as an increase of Ki-67 positivity. Since the lesion showed repeated relapse within a short period, we performed wide-field resection of the tumor with a 3-cm margin. Currently, 48 months after surgery, there has been no local recurrence or metastasis, but continuous strict follow-up will be necessary.

  3. General Information about Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

    ... activities such as sports or have a certain appearance. Whether the cancer is newly diagnosed or has recurred after treatment. ... around it. Limb-sparing surgery : Removal of the tumor in a limb (arm or leg) without amputation , so the use and appearance of the limb is saved. Most patients with ...

  4. Treatment Option Overview (Osteosarcoma and Malignant Fibrous Histiocytoma of Bone)

    ... activities such as sports or have a certain appearance. Whether the cancer is newly diagnosed or has recurred after treatment. ... around it. Limb-sparing surgery : Removal of the tumor in a limb (arm or leg) without amputation , so the use and appearance of the limb is saved. Most patients with ...

  5. Primary intracranial angiomatoid fibrous histiocytoma presenting with anaemia and migraine-like headaches and aura as early clinical features

    Hansen, Jakob Møller; Larsen, Vibeke Andrée; Scheie, David;

    2015-01-01

    A 17-year-old female with migraine with aura complained of fatigue and was diagnosed with anemia. Three years later, changes in her headache pattern prompted hospital referral. Brain MRI showed a bi-lobed extra-axial intracerebral tumor encroaching both parieto-occipital regions. The resection...... specimen yielded a rare diagnosis of primary intracranial angiomatoid fibrous histiocytoma (AFH). Tumor removal resulted in cessation of her migraine and anemia. AFH may cause systemic symptoms--in this case fatigue and anemia--long before focal neurological symptoms are present. This is the first report...... of an intracranial AFH presenting as migraine with visual aura and anemia....

  6. Malignant Solitary Fibrous Tumor of the Scalp.

    Shirley, Brett M; Kang, David R; Sakamoto, Aya Hamao

    2016-07-01

    Solitary fibrous tumors are an uncommon slow growing benign neoplasm originally described as a pleural neoplasm but can also be found in the lung, mediastinum, peritoneum, or any other sites including the head and neck. Malignant solitary fibrous tumors (MSFT) are extremely rare and only few cases have been published in the literature. There have been 19 cases reported of MSFT in the head and neck, but there are no reports of MSFT located within the scalp in the English language literature. We present a case of MSFT arising in the scalp and describe our experience with the clinical presentation, surgical management, and outcome in this pathological condition. PMID:27408445

  7. 99Tcm-MDP whole body bone scan for the ancillary diagnosis of malignant fibrous histiocytoma of bone%99Tcm-MDP全身骨显像诊断骨恶性纤维组织细胞瘤的价值

    魏玲格; 陈敏; 张芳; 郭艾楠; 解朋; 黄建敏; 刘晓梅

    2013-01-01

    Objective To investigate the usefulness of 99Tcm-MDP whole body bone scan in bone malignant fibrous histiocytoma (BMFH).Methods Fifteen patients (11 males,4 females,age ranged from 23 to 60 years,average age (50.4±12.8) years) who had documented BMFH and underwent 99Tcm-MDP whole body bone scan were retrospectively analyzed.The appearance of increased uptake,decreased uptake or defect in radioactivity on bone was considered as positive.The typical scintigraphic manifestations of BMFH were summarized and compared to other radiological imaging data.Results All 15 patients showed positive results.The lesions involved femoral in 10 cases(66.7%),46.7%(7/15) of which was distal femur.The lesions also involved sacrum,tibia,humerus,radius each in 1 case and multiple lesions in 1 case.Among 27 lesions found,63.0% (17/27) showed strong increased radioactivity together with reduced or defect area and 37.0% (10/27) showed strong increased radioactivity only.X-ray found 20 lesions.Twelve cases underwent CT and 7 cases underwent MRI.Abnormal spots showed on CT and MRI were also positive on the whole body bone scan.Conclusions The most common site of BMFH is femur,especially distal femur.BMFH lesions are presented as strong increased radioactivity together with sparse and defect area on bone scan.The whole body bone scan may be an auxiliary examination to evaluate whether there are multiple bone lesions and bone metastasis.%目的 分析骨恶性纤维组织细胞瘤(BMFH)99Tcm-MDP全身骨显像的影像特点,评价其对BMFH的诊断价值.方法 回顾性分析经手术病理证实的BMFH患者15例[男11例,女4例,年龄23~60(50.4±12.8)岁].所有患者术前均行99Tcm-MDP全身骨显像及X线检查,其中12例行CT检查,7例行MRI检查.以骨骼出现放射性异常浓聚灶或稀疏、缺损区为阳性.总结BMFH全身骨显像特点,并将显像结果与其他影像学结果进行比较.结果 15例BMFH患者全身骨显像

  8. Malignant transformation of fibrous dysplasia into chondroblastic osteosarcoma

    A case of malignant transformation of polyostotic fibrous dysplasia into maxillary chondroblastic osteosarcoma is presented. The clinical, radiographic, CT, MR imaging features and pathological findings of polyostotic fibrous dysplasia and its malignant transformation are described. Malignant transformation of fibrous dysplasia is rare and has not previously been described in the English literature in this location in McCune-Albright syndrome and in the absence of radiation treatment. (orig.)

  9. "Malignant" mitral stenosis

    Auer Johann

    2012-03-01

    Full Text Available Abstract Symptomatic mitral stenosis caused by a left atrial mass as the first sign of metastasis of a malignant tumor is extremely rare and frequently associated with poor prognosis. We report a case of a 59-year-old man with a history of grade 3 malignant fibrous histiocytoma on his left tigh treated by limb-sparing surgery 17 months earlier, who was admitted with 10-days of worsening dyspnea. Imaging revealed a left atrial mass protruding through the mitral valve that resulted in severe mitral stenosis. Biopsy confirmed metastasis of malignant fibrous histiocytoma.

  10. Bone Scintigraphy in a Patient With Giant Malignant Solitary Fibrous Tumor of the Pleura.

    Zhao, Long; Liu, JinJun; Li, Qiang; Wang, Huo-Qiang

    2016-06-01

    Chest radiograph performed in a 61-year-old woman to evaluate cough showed a large mass in the right lung. On chest CT images, the mass was measured approximately 8.5 cm. Malignancy was considered, and bone scintigraphy was performed to assess possible osseous metastases. The bone scan images demonstrated increased tracer uptake by the lung mass. The mass was surgically resected, and the pathologic examination confirmed the rare diagnosis of a malignancy solitary fibrous tumors of the pleura. PMID:26914570

  11. Unusual malignant solid neoplasms of the kidney: Cross-sectional imaging findings

    Karaosmanoglu, Ali Devrim; Hahn, Peter F. [Dept. of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston (United States); Shirkhoda, Ali [Dept. of Radiology, University of California School of Medicine, Irvine (United States); Onur, Mehmet Ruhi; Ozmen, Mustafa [Dept. of Radiology, University of Hacettepe School of Medicine, Ankara (Turkmenistan)

    2015-08-15

    Malignant kidney neoplasms are the most frequently encountered solid kidney masses. Although renal cell carcinoma is the major renal malignancy, other solid malignant renal masses should be considered in the differential diagnosis of solid renal masses that do not contain a macroscopic fatty component. In this pictorial essay, we present the imaging findings of a primitive neuroectodermal tumor, primary liposarcoma of the kidney, primary neuroendocrine tumor, leiomyosarcoma, synovial sarcoma, malignant fibrous histiocytoma, sclerosing fibrosarcoma and renal metastasis of osteosarcoma.

  12. Primary malignant bone tumors: diagnosis, radiological appearance and therapy

    Diagnosis, concepts of therapy and prognosis of primary malignant bone tumors require intensive cooperation between orthopedic surgeons, radiologists and pathologists with special knowledge in oncology. The present paper demonstrates relevant topics of diagnosis, radiological appearance and therapy of the osteosarcoma, Ewing's sarcoma, chondrosarcoma and malignant fibrous histiocytoma based on the material of the Vienna Bone Tumor Registry and more than 35 years of cooperation between the Institute of Pathology and Anatomy and the Department of Orthopedics at the University of Vienna. (orig.)

  13. Localized malignant pleural sarcomatoid mesothelioma misdiagnosed as benign localized fibrous tumor.

    Kim, Kwan-Chang; Vo, Hong-Phuc

    2016-06-01

    Localized malignant pleural mesothelioma (LMPM) is a rare tumor with good prognosis by surgical resection. We report an atypical case of malignant pleural sarcomatoid mesothelioma (SM) in an asymptomatic 65-year-old woman, who had no history of exposure to asbestos. She presented with a small pleural mass without pleural effusion and was misdiagnosed as a benign localized fibrous tumor (BLFT) on pathologic examination through a surgical tumor specimen. However, seven months later, the patient returned with serious cancerous symptoms. A large recurrent tumor mass was found within the chest wall invading at the old surgical resection site. SM, a subtype of LMPM, was confirmed with histopathogy and immunohistochemisty. In conclusion, malignant pleural mesothelioma (MPM) can present with typical radiologic finding similar to a BLFT, and has a wide histopathologic presentation in biopsy specimen. A thorough pathologic investigation should be attempted even when a pleural mass resembles benign, localized, and small on radiologic studies. PMID:27293862

  14. Obstructive jaundice caused by secondary pancreatic tumor from malignant solitary fibrous tumor of pleura: A case report

    Norie Yamada; Hiroshi Yotsuyanagi; Michihiro Suzuki; Fumio Itoh; Chiaki Okuse; Masahito Nomoto; Mayu Orita; Yoshiki Katakura; Toshiya Ishii; Takuo Shinmyo; Hiroaki Osada; Ichiro Maeda

    2006-01-01

    A 77-year-old man on systemic chemotherapy against postoperative bilateral multiple lung metastases of malignant solitary fibrous tumor of the pleura suffered from pruritus and jaundice. Blood examination showed elevated levels of hepatobiliary enzymes. Abdominal computed tomography showed a tumor with peripheral enhancement in the pancreatic head, accompanied with the dilatation of intra- and extra-hepatic bile ducts. He was diagnosed as having obstructive jaundice caused by a pancreatic head tumor. The pancreatic head tumor was presumably diagnosed as the metastasis of malignant solitary fibrous tumor of the pleura, because the findings on the pancreatic head tumor on abdominal CT were similar to those on the primary lung lesion of malignant solitary fibrous tumor of the pleura. The pancreatic tumor grew rapidly after the implantation of metallic stent in the inferior part of the common bile duct. The patient died of lymphangitis carcinomatosa of the lungs. Autopsy revealed a tumor that spread from the pancreatic head to the hepatic hilum. Microscopically, spindle-shaped cells exhibiting nuclear atypicality or division together with collagen deposition were observed. Immunohistochemically the pancreatic head tumor cells were negative for staining of α-smooth muscle actin (α-SMA) or CD117, but positive for vimentin, CD34 and CD99. These findings are consistent with thoseon malignant solitary fibrous tumor of the pleura. We report the first case of obstructive jaundice caused by a secondary pancreatic tumor from malignant solitary fibrous tumor of the pleura.

  15. Unexpected finding of elevated glucose uptake in fibrous dysplasia mimicking malignancy: contradicting metabolism and morphology in combined PET/CT

    Stegger, Lars; Weckesser, Matthias [University Hospital of Muenster, Department of Nuclear Medicine (Germany); Juergens, Kai U.; Wormanns, Dag [University Hospital of Muenster, Department of Clinical Radiology (Germany); Kliesch, Sabine [University Hospital of Muenster, Department of Urology (Germany)

    2007-07-15

    Fibrous dysplasia is a common benign disorder of bone in which fibro-osseous tissue replaces bone spongiosa. Lesions have a typical appearance on computed tomography (CT) images and regularly show a markedly increased uptake in bone scintigraphy using {sup 99m}Tc-labelled methylene diphosphonate ({sup 99m}Tc-MDP) as radiotracer. The glucose avidity of these lesions depicted by positron emission tomography (PET) using the radiolabelled glucose derivative {sup 18}F-fluoro-2-deoxy-glucose (FDG) is less well known since FDG-PET does not have a role in the assessment of this disease. However, single cases have been reported in which fibrous dysplasia was present in patients undergoing FDG-PET scanning for oncological reasons, and no significant FDG uptake was observed for lesions identified as fibrous dysplasia. We report on a 24-year-old man with known fibrous dysplasia who underwent combined FDG-PET/CT scanning because of suspected recurrence of testicular cancer. In contrast to prior reports, a markedly elevated uptake of FDG was seen in numerous locations that were identified as fibrous dysplasia by CT. Based on this result, we conclude that fibrous dysplasia may mimick malignancy in FDG-PET and that coregistered CT may help to resolve these equivocal findings. (orig.)

  16. CT findings in malignant pleural mesothelioma related to nonoccupational exposure to asbestos and fibrous zeolite (erionite)

    Endemic malignant pleural mesothelioma (MPM) in Turkey is related to two mineral fibers, tremolite asbestos and fibrous zeolite (erionite). Thirteen cases of MPM from the Cappadocian area, where the soil is rich in erionite, and 29 cases of MPM, from villages whose occupants have high asbestos exposure, were examined by CT. The CT findings of the two groups of MPM were compared with respect to the configuration of the pleural lesions, stage of disease, fissural involvement, pleural effusion, presence of calcified pleural plaques, and chronic fibrosing pleuritis. In erionite-related MPM the pleural lesions were flat and smooth in 69.1%; in asbestos-related MPM the lesions were nodular in 55.1%. Stage IV disease, calcified pleural plaques, and chronic fibrosing pleuritis were more common in the erionite-related MPM. The rest of the findings were similar in both groups. The early radiological diagnosis of erionite-related MPM may be even more difficult because of the similarity of the pleural lesions to chronic fibrosing pleuritis

  17. Tumor fibroso solitário maligno de extremidades Malignant solitary fibrous tumour of the extremities

    Daniel Chang

    2010-01-01

    Full Text Available Tumor fibroso solitário extrapleural (TFS é neoplasia mesenquimal rara, sendo que há menos de 40 casos descritos com localização em extremidades até o presente momento. Acomete preferencialmente pacientes na quinta década e não tem predileção por sexo. Relatamos um caso com os aspectos clínicos, radiológicos, histológicos e imunoistoquímicos característicos, discutindo a importância do diagnóstico diferencial com outros sarcomas.Pouco é conhecido sobre o comportamento biológico do TFS. Fatores de risco para menor sobrevida livre de metástases incluem: margens cirúrgicas comprometidas, tamanho maior que 10 cm e histologia maligna. Excisão completa é o tratamento recomendado.Extrapleural solitary fibrous tumour (SFT is a rare mesenchymal neoplasm, with less than 40 cases reported affecting the extremities so far. This tumour affects preferentially middle-aged patients (median: 50 years and shows no predilection for sex. We report a case with typical clinical, radiologic, histopathologic and immunohistochemical features, discussing the importance of differential diagnosis of other sarcomas. Little is known about the biological behavior of SFT. Risk factors for shorter metastasis-free survival include impaired surgical margins, tumor size greater than 10 cm and malignant histology. Complete excision is the recommended treatment.

  18. Obstructive jaundice caused by secondary pancreatic tumor from malignant solitary fibrous tumor of pleura: A case report

    Yamada, Norie; Okuse, Chiaki; Nomoto, Masahito; Orita, Mayu; Katakura, Yoshiki; Ishii, Toshiya; Shinmyo, Takuo; Osada, Hiroaki; Maeda, Ichiro; Yotsuyanagi, Hiroshi; Suzuki, Michihiro; Itoh, Fumio

    2006-01-01

    A 77-year-old man on systemic chemotherapy against postoperative bilateral multiple lung metastases of malignant solitary fibrous tumor of the pleura suffered from pruritus and jaundice. Blood examination showed elevated levels of hepatobiliary enzymes. Abdominal computed tomography showed a tumor with peripheral enhancement in the pancreatic head, accompanied with the dilatation of intra- and extra-hepatic bile ducts. He was diagnosed as having obstructive jaundice caused by a pancreatic hea...

  19. Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas

    Jensen, V; Sørensen, Flemming Brandt; Bentzen, S M;

    1998-01-01

    AIMS: To evaluate the prognostic value of tumour proliferative activity, p53 accumulation and bcl-2 expression in a retrospective series of 216 patients with soft tissue sarcomas (STS). METHODS AND RESULTS: The immunohistochemical analyses were performed on formalin-fixed, paraffin-embedded tissue...

  20. Primary malignant bone tumors: diagnosis, radiological appearance and therapy; Primaer maligne Knochentumoren: Klinik und Therapie

    Dominkus, M.; Kotz, R. [Universitaetsklinik fuer Orthopaedie, Wien (Austria); Kainberger, F. [Abt. fuer Osteoradiologie, Universitaetsklinik fuer Radiologie, Wien (Austria); Lang, S. [Wien Univ. (Austria). Universitaetsklinik fuer Pathologische Anatomie

    1998-06-01

    Diagnosis, concepts of therapy and prognosis of primary malignant bone tumors require intensive cooperation between orthopedic surgeons, radiologists and pathologists with special knowledge in oncology. The present paper demonstrates relevant topics of diagnosis, radiological appearance and therapy of the osteosarcoma, Ewing`s sarcoma, chondrosarcoma and malignant fibrous histiocytoma based on the material of the Vienna Bone Tumor Registry and more than 35 years of cooperation between the Institute of Pathology and Anatomy and the Department of Orthopedics at the University of Vienna. (orig.) [Deutsch] Fuer die Diagnose, Therapieplanung und Prognosebeurteilung von primaer malignen Knochentumoren ist eine intensive Kooperation von onkologisch speziell ausgebildeten Fachdisziplinen wie Orthopaedie, Radiologie und Pathologie erforderlich. Die vorliegende Arbeit basiert auf dem Material des Wiener Knochengeschwulstregisters und der 35jaehrigen Zusammenarbeit des Pathologisch/Anatomischen Instituts der Universitaet Wien mit der Universitaetsklinik fuer Orthopaedie und beschreibt Diagnose, radiologisches Erscheinungsbild und Therapie der 4 haeufigsten primaer malignen Knochentumoren: Osteosarkom, Ewing`s Sarkom, Chondrosarkom und malignes fibroeses Histiozytom. (orig.)

  1. Doege-Potter syndrome presenting with hypoinsulinemic hypoglycemia in a patient with a malignant extrapleural solitary fibrous tumor: a case report

    Schutt Robert C

    2013-01-01

    Full Text Available Abstract Introduction Doege-Potter syndrome is a paraneoplastic syndrome characterized by non-islet cell tumor hypoglycemia secondary to a solitary fibrous tumor. This tumor causes hypoglycemia by the secretion of a prohormone form of insulin-like growth factor II. We describe the diagnosis and management of Doege-Potter syndrome and the use of transarterial chemoembolization in a patient with a malignant extrapleural solitary fibrous tumor. Case presentation Our patient was a 64-year-old Caucasian woman who initially presented with urinary incontinence and was found to have a 14.5×9.0×9.0cm retroperitoneal solitary fibrous tumor compressing her bladder. Her tumor was surgically resected but recurred with multiple hepatic metastatic lesions. The hepatic metastases progressed despite systemic chemotherapy and treatment with doxorubicin transarterial chemoembolization. Her course was complicated by the development of recurrent fasting hypoglycemia, most likely secondary to Doege-Potter syndrome. Her hypoglycemia was managed with corticosteroid therapy and frequent scheduled nutrient intake overnight. Conclusions The rarity of hepatic solitary fibrous tumors and consequent lack of controlled trials make this report significant in that it describes the diagnostic approach to Doege-Potter syndrome, describes our experience with the use of doxorubicin transarterial chemoembolization, and presents management options for tumor-associated hypoglycemia in the case of extensive disease not amenable to surgical resection.

  2. Spontaneous malignant transformation of conventional giant cell tumor

    Grote, H.J.; Pomjanski, N.; Boecking, A. [Institute of Cytopathology, Heinrich Heine University, Moorenstrasse 5, 40225, Duesseldorf (Germany); Braun, M. [Orthopedic Hospital Volmarstein, University of Witten/Herdecke, Hartmannstrasse 24, 58300, Wetter (Ruhr) (Germany); Kalinski, T.; Roessner, A. [Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg (Germany); Back, W.; Bleyl, U. [Department of Pathology, Ruprecht Karls University Heidelberg, University Hospital Mannheim, Theodor-Kutzer-Ufer, 68167, Mannheim (Germany)

    2004-03-01

    Spontaneous malignant transformation of conventional giant cell tumor (GCT) of bone is exceedingly rare. We report on a case of GCT of the iliac crest in a 35-year-old woman with malignant change into a high-grade osteosarcoma 10 years after the first appearance of GCT on a radiograph. Since the patient refused therapy for personal reasons the tumor remained untreated until sarcomatous transformation occurred. Image cytometry showed DNA aneuploidy and a suspiciously high 2c deviation index (2cDI) in the primary bone lesion. A thorough review of the world literature revealed only seven fully documented cases of secondary malignant GCT which matched the definition of a ''sarcomatous growth that occurs at the site of a previously documented benign giant cell tumor'' and not treated by radiotherapy. These cases as well as the current one suggest that a spontaneous secondary malignant GCT presents as a frankly sarcomatous tumor in the form of an osteosarcoma or malignant fibrous histiocytoma. It usually appears at sites of typical GCTs - often without any recurrent intermediate state - and is diagnosed 3 or more years after the primary bone lesion. The prognosis is poor. (orig.)

  3. Massive chest wall resection and reconstruction for malignant disease

    Foroulis, Christophoros N; Kleontas, Athanassios D; Tagarakis, George; Nana, Chryssoula; Alexiou, Ioannis; Grosomanidis, Vasilis; Tossios, Paschalis; Papadaki, Elena; Kioumis, Ioannis; Baka, Sofia; Zarogoulidis, Paul; Anastasiadis, Kyriakos

    2016-01-01

    Objective Malignant chest wall tumors are rare neoplasms. Resection with wide-free margins is an important prognostic factor, and massive chest wall resection and reconstruction are often necessary. A recent case series of 20 consecutive patients is reported in order to find any possible correlation between tumor histology, extent of resection, type of reconstruction, and adjuvant treatment with short- and long-term outcomes. Methods Twenty patients were submitted to chest wall resection and reconstruction for malignant chest wall neoplasms between 2006 and 2014. The mean age (ten males) was 59±4 years. The size and histology of the tumor, the technique of reconstruction, and the short- and long-term follow-up records were noted. Results The median maximum diameter of tumors was 10 cm (5.4–32 cm). Subtotal sternal resection was performed in nine cases, and the resection of multiple ribs was performed in eleven cases. The median area of chest wall defect was 108 cm2 (60–340 cm2). Histology revealed soft tissue, bone, and cartilage sarcomas in 16 cases (80%), most of them chondrosarcomas. The rest of the tumors was metastatic tumors in two cases and localized malignant pleural mesothelioma and non-Hodgkin lymphoma in one case. The chest wall defect was reconstructed by using the “sandwich technique” (propylene mesh/methyl methacrylate/propylene mesh) in nine cases of large anterior defects or by using a 2 mm polytetrafluoroethylene (e-PTFE) mesh in nine cases of lateral or posterior defects. Support from a plastic surgeon was necessary to cover the full-thickness chest wall defects in seven cases. Adjuvant oncologic treatment was administered in 13 patients. Local recurrences were observed in five cases where surgical reintervention was finally necessary in two cases. Recurrences were associated with larger tumors, histology of malignant fibrous histiocytoma, and initial incomplete resection or misdiagnosis made by nonthoracic surgeons. Three patients died

  4. Quantification of the magnetization-transfer contrast effect: can it yield additional information in differentiation of musculoskeletal lesions particularly in separation of benign from malignant lesions

    Purpose: To investigate the potential information of the amount of magnetization-transfer effect in musculoskeletal lesions and to compare MT ratios from benign and malignant musculoskeletal lesions. Material and Method: 49 patients with malignant tumors (3 osteosarcoma, 3 malignant fibrous histiocytoma, 4 chondrosarcoma, 2 Ewing sarcomas) and benign lesions (8 chondroma, 2 fibrous dysplasia, 3 osteoid-osteoma, 6 ganglion cyst, 3 cyst, 3 osteomyelitis, 4 tendinitis, 3 rotator cuff tear, 5 scar tissue) were scanned using routine MRI protocols including T1- and T2-weighted spin echo as well as T2*-weighted gradient echo (FFE) sequences at 1.5 Tesla (ACS II, Philips Medical). Additionally MTC images were generated by combining the FFE sequence and the off-resonance MT technique (-1500 Hz off-resonance frequency, 1770 flip angle and 50 ms pulse duration). MT ratios were calculated as SIo-SIm/SIo. Results: The MT ratio of benign lesions was 26±15%, that of malignant lesions was 22±6%. The difference was statistically not significant. As expected muscle showed a high MT ratio of 50±8%. Scar tissue demonstrated an MT ratio of 39±16% which was significantly higher than the tumor MT ratios. Conclusion: MTC (MT ratios) failed to show significant differences between benign and malignant lesions as was expected due to basic differences in cellularity, rate of mitosis and chromatin content. MTC might however gain more importance in separating scar tissue from recurrent tumor in the future. (orig.)

  5. Definitive intraoperative radiotherapy for musculoskeletal sarcomas and malignant lymphoma in combination with surgical excision

    The purpose was to estimate retrospectively the outcome of patients with musculoskeletal sarcoma or malignant lymphoma treated with intraoperative radiotherapy (IORT). Between 1988 and 1999, definitive IORT in combination with surgical excision was performed in 24 patients with musculoskeletal sarcoma (malignant fibrous histiocytoma, 10; osteosarcoma, 6; liposarcoma, 2; chondrosarcoma, 1; synovial sarcoma, 1; Ewing's sarcoma, 1; angiosarcoma, 1; epithelioid sarcoma, 1; malignant schwannoma, 1; and 3 patients with malignant lymphoma. The tumor was excised by marginal margin excision, intralesional margin excision, or wide margin excision; 15-45 Gy electrons was then delivered to the affected sites. In the 8 patients without distant metastases at the first visit, 4 patients are alive 6.5-11.5 years after IORT, and 4 patients died <4.5 years after IORT. The incidence of local recurrence was 13%. In the 19 patients with distant metastases at the first visit, 3 patients are alive 2.5-6.7 years after IORT, and 16 patients died 0.2-5.7 years after IORT. The incidence of local recurrence was 45%. Complications after IORT were found in 5 patients: neuropathy, 1 patient; skin necrosis, 1 patient; myelopathy, 1 patient; enteritis ileus, 1 patient; and edema, 1 patient. IORT with a radiation dose of 15-45 Gy in combination with surgical excision appeared to be useful for local control and to be more effective in patients without distant metastases at the first visit than in patients with distant metastases. (author)

  6. The Study of the Malignant Tumors of the Maxillary Sinus by Computed Tomography

    CT findings of proven 25 malignant tumors of the maxillary sinus were retrospectively analyzed to be of help in the diagnosis and treatment. The results were as follow: 1. Average age was 54 years old, and eighteen were males and seven were females with a ratio of 2.6:1. 2. The most common histopathologic feature was squamous cell carcinoma (19 cases) and others were two cases of adenoid cystic carcinoma, one case of malignant fibrous histiocytoma, mucoepidermoid tumor, histiocytic lymphoma, unidentified malignant tumor. 3. CT findings were sinus opacification (4%), soft tissue mass (92%), low densities within soft tissue mass (44%), air densities within soft tissue mass (24%), osteosclerosis (4%), bone destruction (92%), bone displacement (32%), fat plane obliteration(76%). 4. CT in the malignant maxillary sinus tumors approved the value in evaluation of tumor extension to nasal cavity, ethmoid sinus, orbit, infratemporal fossa, pterygopalatine fossa, pterygoid fossa, pterygoid muscle, cheek skin and intracranial cavity. 5. Twenty four cases (96%) were stage III, stage IV according to AJCC TNM classification. 6. Bone findings were destruction, displacement, sclerosis and most frequent site of bone destruction was the medial wall of the antrum (92%). 7. Tumor growth pattern showed destructive pattern in 18 cases (72%), and squamous cell carcinoma showed destructive pattern. (p<0.05).

  7. The Study of the Malignant Tumors of the Maxillary Sinus by Computed Tomography

    Dan, Jung Bae; Park, Tae Won [Dept. of Oral Radiology, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    1989-11-15

    CT findings of proven 25 malignant tumors of the maxillary sinus were retrospectively analyzed to be of help in the diagnosis and treatment. The results were as follow: 1. Average age was 54 years old, and eighteen were males and seven were females with a ratio of 2.6:1. 2. The most common histopathologic feature was squamous cell carcinoma (19 cases) and others were two cases of adenoid cystic carcinoma, one case of malignant fibrous histiocytoma, mucoepidermoid tumor, histiocytic lymphoma, unidentified malignant tumor. 3. CT findings were sinus opacification (4%), soft tissue mass (92%), low densities within soft tissue mass (44%), air densities within soft tissue mass (24%), osteosclerosis (4%), bone destruction (92%), bone displacement (32%), fat plane obliteration(76%). 4. CT in the malignant maxillary sinus tumors approved the value in evaluation of tumor extension to nasal cavity, ethmoid sinus, orbit, infratemporal fossa, pterygopalatine fossa, pterygoid fossa, pterygoid muscle, cheek skin and intracranial cavity. 5. Twenty four cases (96%) were stage III, stage IV according to AJCC TNM classification. 6. Bone findings were destruction, displacement, sclerosis and most frequent site of bone destruction was the medial wall of the antrum (92%). 7. Tumor growth pattern showed destructive pattern in 18 cases (72%), and squamous cell carcinoma showed destructive pattern. (p<0.05).

  8. Prevalence of Malignant Soft Tissue Tumors inExtremities: An Epidemiological Study in Syria

    Habib Reshadi

    2014-06-01

    Full Text Available Background:   Although the majority of soft tissue masses are benign, it is important to consider malignancy in differential diagnoses. Because most soft tissue sarcomas present as a painless mass, clinicians must watch for signs suggestive of malignancy, including large size, rapid growth, and site deep into the deep fascia.The purpose of this study was to determine the relative prevalence according to sex and age, site of tumor, skeletal distribution, and treatment (surgery, chemotherapy and radiotherapy before and after surgery, and ascertain the relative frequency of these tumors in specific anatomic sites and age groups based on pathological studies. Methods: A total of 308 patients, with a musculoskeletal tumor were evaluated retrospectively. All of the patients enrolled into this study were referred to the Beirouni Hospital of Damascus University with a proven diagnosis of alignant soft tissue tumors from the beginning of January 2008 until the end of 2010. The prevalence of the malignant soft tissue tumors in these patients was analyzed. For purposes of analysis, all lesions were placed in 1 of 9 categories: hand and wrist, forearm, humorous (arm, proximal limb girdle (axilla and shoulder, foot and ankle, thigh, hip and buttocks region, trunk, and other lesions. Age and sex also were recorded. Results: Malignant tumors consisted of seven diagnostic categories: malignant fibrous histiocytoma (23%, liposarcoma (22%, rhabdomyosarcoma (9%, leiomyosarcoma (8%, malignant schwannoma (5%, dermatofibrosarcoma protuberans (5%, synovial sarcoma (10%, fibrosarcoma (13%, extraskeletal chondrosarcoma (1%, and extraskeletal Ewing sarcoma (4%. Conclusions: Despite the multitude of pathologic possibilities, most malignant soft-tissue tumors are classified into a small number of diagnoses. These may be further defined when the site of the lesion and the age of the patient are considered. Knowledge of tumor prevalence will assist radiologists in

  9. Fibrous dysplasia and cherubism.

    Bhattacharya, Surajit; Mishra, R K

    2015-01-01

    Fibrous dysplasia (FD) is a non-malignant fibro-osseous bony lesion in which the involved bone/bones gradually get converted into expanding cystic and fibrous tissue. The underlying defect in FD is post-natal mutation of GNAS1 gene, which leads to the proliferation and activation of undifferentiated mesenchymal cells arresting the bone development in woven phase and ultimately converting them into fibro-osseous cystic tissue. Cherubism is a hereditary form of fibrous dysplasia in which the causative factor is transmission of autosomal dominant SH3BP2 gene mutation. The disease may present in two distinct forms, a less severe and limited monostotic form, and a more aggressive and more widespread polyostotic form. Polyostotic form may be associated with various endocrine abnormalities, which require active management apart from the management of FD. Management of FD is not free from controversies. While total surgical excision of the involved area and reconstruction using newer micro-vascular technique is the only definitive treatment available from the curative point of view, but this can be only offered to monostotic and very few polyostotic lesions. In polyostotic varieties on many occasions these radical surgeries are very deforming in these slow growing lesions and so their indication is highly debated. The treatment of cranio-facial fibrous dysplasia should be highly individualized, depending on the fact that the clinical behavior of lesion is variable at various ages and in individual patients. A more conservative approach in the form of aesthetic recontouring of deformed bone, orthodontic occlusal correction, and watchful expectancy may be the more accepted form of treatment in young patients. Newer generation real-time imaging guidance during recontouring surgery adds to accuracy and safety of these procedures. Regular clinical and radiological follow up is required to watch for quiescence, regression or reactivation of the disease process. Patients must be

  10. Highly malignant soft tissue sarcoma of the extremity with a delayed diagnosis

    Chae In

    2010-09-01

    Full Text Available Abstract Purpose To evaluate the characteristics of highly malignant soft tissue sarcoma of the extremity with a delayed diagnosis. Materials and methods The clinical and radiological characteristics of 18 cases of highly malignant soft tissue sarcomas of the extremity with a delayed diagnosis were determined. Results Ten men and eight women of mean age 44.8 years (range, 15-79 years were included in this study. Seven cases of synovial sarcoma, three cases each of alveolar soft part sarcoma and malignant fibrous histiocytoma, two cases each of highly malignant leiomyosarcoma and myxofibrosarcoma, and one case of clear cell sarcoma were enrolled. Times from tumor detection to diagnosis ranged from 1 to 3 years in most cases; three of the seven synovial sarcoma cases took more than 10 years to diagnose. Of the seven cases of synovial sarcoma, five cases of small, superficial located masses were simply excised without a pre-surgical biopsy. Three cases of alveolar soft part sarcoma showed characteristic T1- and T2-weighted high signal intensities with signal voids in MR images. In addition, one synovial sarcoma patient and one alveolar soft part sarcoma patient showed evidence of calcification on plain radiographs. However, no general characteristic clinical findings were found to be common to the 18 cases. Conclusions Contrary to general expectations, some soft tissue tumors that grow slowly are painless, and those that occur in superficial limbs may be highly malignant. Thus, even when a slow growing, painless superficial mass is encountered in a limb, physicians should keep the possibility of highly malignant soft tissue sarcoma in mind.

  11. Mesothelioma - benign-fibrous

    Mesothelioma - benign; Mesothelioma - fibrous; Pleural fibroma; Solitary fibrous tumor of the pleura ... other reasons. Other tests that may show benign mesothelioma include: CT scan of the chest Open lung ...

  12. Massive chest wall resection and reconstruction for malignant disease

    Foroulis CN

    2016-04-01

    mm polytetrafluoroethylene (e-PTFE mesh in nine cases of lateral or posterior defects. Support from a plastic surgeon was necessary to cover the full-thickness chest wall defects in seven cases. Adjuvant oncologic treatment was administered in 13 patients. Local recurrences were observed in five cases where surgical reintervention was finally necessary in two cases. Recurrences were associated with larger tumors, histology of malignant fibrous histiocytoma, and initial incomplete resection or misdiagnosis made by nonthoracic surgeons. Three patients died during the study period because of recurrent disease or complications of treatment for recurrent disease.Conclusion: Chest wall tumors are in their majority mesenchymal neoplasms, which often require major chest wall resection for their eradication. Long-term survival is expected in low-grade tumors where a radical resection is achieved, while big tumors and histology of malignant fibrous histiocytoma are connected with the increase rate of recurrence.Keywords: chest wall tumors, chest wall resection, chest wall reconstruction, soft tissue sarcomas, sternal tumors, chondrosarcoma 

  13. A case of congenital solitary Langerhans cell histiocytoma.

    Ricciardo, Bernadette

    2012-02-01

    A newborn baby boy was referred to the Paediatric Dermatology Unit with a solitary asymptomatic nodule overlying his right nasolabial fold. Complete physical examination, full blood count, serum chemistry, liver function tests and baseline imaging were unremarkable. Histopathological examination showed an atypical dermal infiltrate of mononuclear cells that stained positive with CD1a and S100. A diagnosis of congenital solitary Langerhans cell histiocytoma was made. The lesion completely resolved by 4 months of age. The baby is now 15 months old and repeat systemic evaluation has remained normal.

  14. Fibrous dysplasia of bone: a clinicopathologic review

    Mohan H

    2011-11-01

    Full Text Available Harsh Mohan1, Preeti Mittal1, Irneet Mundi1, Sudhir Kumar21Department of Pathology, 2Department of Orthopedics, Government Medical College, Sector 32, Chandigarh, IndiaAbstract: Fibrous dysplasia of the bones is an uncommon congenital skeletal disorder that is found equally in both genders and is not inherited. Its etiology has been linked to an activating mutation of Gsα and the downstream effects of the resultant increase in cAMP. Fibrous dysplasia is categorized as either monostotic or polyostotic, and may occur as a component of McCune-Albright syndrome or the rare Mazabraud syndrome. Long bones, skull bones, and ribs are the most commonly affected bones. The radiological picture is somewhat variable, including a ground-glass appearance, expansion of the bone, and sclerosis surrounding the lesion. Histologically, fibrous dysplasia shows irregularly-shaped trabeculae of immature, woven bone in a background of variably cellular, loosely arranged fibrous stroma. It may be complicated by pathologic fracture, and rarely by malignant transformation. This review examines interesting issues surrounding the etiology of fibrous dysplasia, its clinical and laboratory manifestations, radiological picture, utility of bone biopsy, gross and microscopic pathology, complications, and its differential diagnostic considerations.Keywords: fibrous dysplasia, McCune-Albright syndrome, monostotic form, polyostotic form

  15. Polyostotic fibrous dysplasia

    Fibrous dysplasia is a benign fibro-osseous condition that is replacement of normal bone and marrow tissues by cellular fibrous tissue and immature bone, and it is divided into monostotic type and polyostotic type. Polyostotic fibrous dysplasia involves multiple bones, such as skull, jaw bones, femur and tibia. And it is also divided into two forms: the less severe Jaffe's type and the more severe Albright's syndrome. Clinically, it frequently occurs in the 2nd decade, and occurs more frequently in maxilla than in mandible. And the lesions of fibrous dysplasia tend to become static as skeletal maturity is reached. The authors experienced three cases of polyostosic fibrous dysplasia in the craniofacial area with the complaints of facial asymmetry due to painless swelling. And we discussed the clinical, radiological, and histopathological features of these cases with a brief review of the literatures.

  16. Polyostotic fibrous dysplasia

    Lee, Kang Sook; Park, Sang Eok; Choi, Karp Shik [Dept. of Dental Radiology, College of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    1994-02-15

    Fibrous dysplasia is a benign fibro-osseous condition that is replacement of normal bone and marrow tissues by cellular fibrous tissue and immature bone, and it is divided into monostotic type and polyostotic type. Polyostotic fibrous dysplasia involves multiple bones, such as skull, jaw bones, femur and tibia. And it is also divided into two forms: the less severe Jaffe's type and the more severe Albright's syndrome. Clinically, it frequently occurs in the 2nd decade, and occurs more frequently in maxilla than in mandible. And the lesions of fibrous dysplasia tend to become static as skeletal maturity is reached. The authors experienced three cases of polyostosic fibrous dysplasia in the craniofacial area with the complaints of facial asymmetry due to painless swelling. And we discussed the clinical, radiological, and histopathological features of these cases with a brief review of the literatures.

  17. Craniofacial fibrous dysplasia

    Aakarsh Jhamb

    2012-01-01

    Full Text Available Fibrous dysplasia can present clinically in varied forms which may appear as collision of different pathologic processes. We report a rare case of craniofacial fibrous dysplasia with coexisting epithelial lined cyst and superimposed osteomyelitis with sequestrum formation. Its clinical features and management with possible hypotheses are described along with the post operative course. Pertinent literature has been reviewed with emphasis on pathogenesis of this unique occurrence.

  18. Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience

    DeVito, Nicholas; Henderson, Evita; Han, Gang; Reed, Damon; Marilyn M Bui; Lavey, Robert; Robinson, Lary; Zager, Jonathan S.; Gonzalez, Ricardo J; Sondak, Vernon K.; Letson, G. Douglas; Conley, Anthony

    2015-01-01

    Solitary fibrous tumor (SFT) is a mesenchymal neoplasm of fibrous origin. The 2013 WHO classification of soft tissue tumors defines malignant forms as hypercellular, mitotically active (>4 mitosis/10 high-power fields), with cytological atypia, tumor necrosis, and/or infiltrative margins. With an IRB-approved protocol, we investigated patient records and clinicopathologic data from our Sarcoma Database to describe the clinical characteristics of both benign and malignant SFT. All pathology sp...

  19. Craniofacial fibrous dysplasia - radiological findings

    A short literature review of fibrous dysplasia is made. The clinical and diagnostic problems concerning localization of fibrous bone changes in cranio-facial region are precisely discussed. A classification of myelofibrosis lesions due to clinical forms, localization of changes and presence of another disturbances (pigmentations, endocrinopathies etc.) is presented. Two cases of accidentally found fibrous lesions of the skull and jaws during radiological (CBCT) examination because of dental implant treatment are described. (authors) Key words: ALBRIGHT SYNDROME. CRANIOFACIAL FIBROUS DYSPLASIA, FIBROUS BONE LESION. LICHTENSTEIN SYNDROME. MYELOFIBROUS LESION

  20. [About a case of calcifying fibrous tumor of the pleura].

    Rocas, Delphine; Thivolet-Béjui, Françoise; Tronc, François; Chalabreysse, Lara

    2015-12-01

    Calcifying fibrous tumor is a rare soft tissue benign tumor (OMS 2002). Some pleural localisations are described, which affect slightly older individuals than the other soft tissue forms. The calcifying fibrous tumor is included in the 2004 World Health Organization classification of pleural tumors. A pleural tumor located in the right inferior pulmonary lobe is diagnosed in a 59-year-old man. This pleural tumor is macroscopically well-circumscribed. Histologically, the rare spindle tumoral cells are located between bundles of a collagenous tissue, sometimes hyalinized, with psammomatous or dystrophic calcifications. The tumoral cells have a fibrohistiocytic origin. They stain positively for antibodies against vimentin, factor XIIIa, CD68, CD163, CD34. Antibodies against smooth muscle actin, desmin, PS100, ALK1 and EBV are negative. Main differencial diagnoses are other benign pleural tumors (solitary fibrous tumor, inflammatory myofibroblastique tumor), some malignant tumors (desmoplastic malignant pleural mesothelioma) and pleural pseudotumors (calcified pleural plaques, chronic fibrous pleuritis, amylose, hyalinizing granuloma). Our case is the 15th pleural calcifying fibrous tumor being reported. PMID:26608111

  1. 伴恶性纤维组织细胞瘤去分化股骨远端脂肪肉瘤一例%Dedifferentiated liposarcoma in the distal femur accompanied by malignant fibrous histiocytoma:a case report

    张帅; 王序全

    2013-01-01

    Primary intraosseous liposarcoma was a rare and malignant tumor of the skeletal system. It originated from the intraosseous adipose tissue. Since the first case was reported in 1931, there were only dozens of cases reported at home and abroad now, without the unified standard for diagnosis and treatment. Recently, a patient with intraosseous dedifferentiated liposarcoma was adopted by our department. Neither recurrence nor metastasis had been detected for 2 months after surgery.

  2. Rare solitary fibrous tumor of the stomach: A case report

    Bošković Tamara

    2015-01-01

    Full Text Available Introduction. Solitary fibrous tumors are rare soft tissue tumors of submesothelial origin and variable malignant potential. The most common localization is pleural, whereas only 0.6% are of extrapleural localization. Solitary fibrous tumor of the peritoneum, especially of gastric serosa is an extremely rare form of this tumor. Case report. We presented a 65- year-old female patient with solitary fibrous tumor of the stomach. Histopathological analysis of removed tissue showed the presence of tumor tissue built of spindle cells, elongated nuclei with moderately abundant cytoplasm. Cells were in a noncohesive arrangement, in smaller areas distributed in the form of palisade. There were amounts of hipocellular connective tissue, hyalinised, with small foci of dystrophic calcification. Mitoses were rare (less than 3/10 HPF. Blood vessels surrounded the connective tissue. Reviewed material did not contain elements of the parent organ. Immunohistochemically there were positivity on CD34 and vimentin, and negativity to S100, SMA, CD117, dezmin, and Ki-67 is < 2%. The change was diagnosed as a solitary fibrous tumor. Conclusion. Considering that benign solitary fibrous tumors of extrathoracic localizations are extremely rare neoplasms with unpredictable biological behavior and the possibility of recurrence, a long-term clinical and endoscopic follow-up on yearly basis of patients with this disease is recommended.

  3. Retroperitoneal calcifying fibrous tumor mimicking an adrenal tumor

    Prochaska, Erica C.; Sciallis, Andrew P.; Miller, Barbra S.

    2016-01-01

    Establishing the etiology of a retroperitoneal tumor may be difficult due to close proximity of multiple organs. Evaluation of retroperitoneal tumors often leads to surgery, many times to obtain a definitive diagnosis and rule out malignancy. Calcifying fibrous tumors (CFT) are very rare soft tissue tumors occurring most often in young patients. They are most often found arising in the thoracic cavity, mediastinum, abdominal cavity and extremities and usually have a benign clinical course. Ma...

  4. Fibrous Pseudotumor of the Penis – An Unusual Finding During Repair of Fractured Penis

    Sunny Nalavenkata; Matthew Winter; Justine Pickett; Maxwell Dias; Venu Chalasani

    2014-01-01

    Fibrous pseudotumors of the testis and penis are a rare phenomenon, forming a spectrum of heterogeneous lesions. To the best of our knowledge, there has been only 1 previous report arising from the penis. We present a case of fibrous pseudotumor of the penis, incidentally found during the surgical repair of a fractured penis. These benign lesions have been described in the literature and are most commonly referred to as pseudotumors. They should be distinguished from potentially malignant les...

  5. Calcified fibrous pseudotumor of spermatic cord

    Paratesticular tumors are infrequent and most are benigns. This a case presentation of a patient aged 24 with a history of good health coming to our consultation by presence of a hard and painless 4 cm tumor in right scrotum with a 6 months course. Scrotal ultrasound (US) showed a well circumscribed heterogeneous lesion separate of epididymis and the testis. Fine needle aspiration biopsy (FNAB) was not possible by hardness of tumor. A inguinal surgery was performed and the total tumor exeresis using freezing biopsy negative of malignancy. Final histopathological report was: calcified fibrous pseudotumor of spermatic cord. Patient's course has been satisfactory. Significance of inguinal surgery was confirmed for the paratesticular tumor approach, even more when FNAB it is not conclusive for diagnosis.(author)

  6. Solitary fibrous tumor of the pancreas.

    Baxter, Andrew R; Newman, Elliot; Hajdu, Cristina H

    2015-01-01

    Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms of fibroblastic origin. Most commonly they affect the pleura but they been described in other viscera. SFT of the pancreas is extremely rare, and only eight cases have been reported to date. We perform a literature review and report a ninth case. The patient is a 54-year-old African-American female who presented with several months of abdominal pain. Abdominal radiography demonstrated a lesion in the head of the pancreas, and she underwent a Whipple operation. Pathology demonstrated SFT of the pancreas. She is alive and well 1 year post-operatively. SFT of the pancreas predominately affects middle-aged women. These tumors are difficult to distinguish radiologically from neuroendocrine tumors. While SFT of the pancreas tend to have an indolent course, there is the potential for malignancy. We recommend complete surgical excision. PMID:26628714

  7. Ovarian cystadenofibroma: A masquerader of malignancy

    Wasnik Ashish; Elsayes Khaled

    2010-01-01

    Ovarian cystadenofibroma is a relatively rare benign ovarian tumor that contains both epithelial and fibrous stromal components. The appearance of cystadenofibroma on imaging is often complex; cystic- to solid-appearing masses may be visualized and it often resembles a malignant tumor. Owing to the fibrous component of this tumor, MRI shows low-signal intensity on T2W images. This finding may help a radiologist make a preoperative diagnosis of this tumor and thus perhaps avoid aggressive surg...

  8. A rare mesenchymal neoplasm at unusual location: Solitary fibrous tumor of vulva

    Nag, G.; Rao, S.R.

    2015-01-01

    •We report a rare case of solitary fibrous tumor of vulva.•The lesion is usually benign.•Needs workup for malignant features and other close differentials.•Early aggressive resection ensuring clear margins is recommended.•Tendency for recurrence warrants long term follow-up.

  9. Solitary fibrous tumor of the greater omentum mimicking an ovarian tumor in a young woman.

    Rodriguez Tarrega, Elisabet; Hidalgo Mora, Juan Jose; Paya Amate, Vicente; Vega Oomen, Olivia

    2016-08-01

    We report a case of solitary fibrous tumor (SFT) of greater omentum in a young woman. SFT arising from the greater omentum can mimic a gynecologic neoplasm. SFTs are generally benign but some of them are malignant and have uncertain prognosis. An adequate follow-up is essential in these patients. PMID:27354994

  10. Bone scintigraphy in polyostotic fibrous dysplasia

    Wadhwa, S.S.; Mansberg, R.; Fernandes, V.B. [Illawarra Regional Hospital, Wollongong, NSW, (Australia)

    1998-03-01

    Fibrous dysplasia is a benign skeletal disorder of unknown aetiology. Fibrous dysplasia characteristically involves the fibrous replacement of portions of the medullary cavities of a single bone (monostotic) or multiple bones (polyostotic). Bones typically involved include the femurs, tibiae, ribs and maxillae. The polyostotic form may be accompanied by skin pigmentation and endocrine abnormalities (McCune Allbright Syndrome). Radiological findings in fibrous dysplasia are variable, ranging from completely radiolucent to radio-opaque lesions, depending on the amount of fibrous or osseous tissue deposited in the medulla. The most common radiographic finding is that of a ground glass-like semi-opaque lesion. Case reports on scintigraphic manifestation of fibrous dysplasia are scanty. We present radiological and scintigraphic findings of polyostotic fibrous dysplasia in a young male. (authors). 3 refs., 1 fig.

  11. Primary malignant liver mesenchymal tumor: A case report

    2010-01-01

    Primary malignant liver mesenchymal tumor is a rare condition defined as a tumor with vascular, fibrous, adi-pose, and other mesenchymal tissue differentiation. We report a case of primary malignant liver mesenchymal tumor in a 51-year-old male with anemia, weight loss and hepatomegaly. Finally unconventional liver biopsy and histological manifestation led to the definitive diag-nosis.

  12. Clinicopathological analysis of solitary fibrous tumor

    Xiumei Zhang; Hai Wang; Shujing Wang; Jinfeng Miao; Zhengai Piao; Yingying Dong

    2012-01-01

    Objective: The aim of this study was to investigate the clinicopathologic characteristics, diagnosis and differential diagnosis, molecular genetics, treatment and prognosis of solitary fibrous tumor (SFT). Methods: The clinicopathological manifestations were analyzed retrospectively in 22 patients with surgically confirmed SFT. Results: There were 12 male patients and 10 female patients, with the age range 33–67 (mean 48.62) years. The SFTs originated from different from parts of the body, including 13 in the chest, 2 in the lungs, 3 in the abdomen, 1 in the lumbosacral area, 2 in the pelvis, and 1 in the left shoulder. There were 19 benign and 3 malignant tumors. Major clinical presentations were local masses and compression symptoms. Microscopy: the tumor was composed of areas of alternating hypercellularity and hypocellularity. The tumor cells were spindle to short-spindle shaped and arranged in fascicular or storiform pattern and hemangiopericytoma-like structure was presented. Immunohistochemically, Vimentin positive rate was 100% (22/22), Bcl-2 positive rate was 95.5% (21/22), CD99 positive rate was 86.4% (19/22), CD34 positive rate was 81.8 (18/22), focally positive for P53, as well as negative CK, S100 and Desmin. Ki67 labelling index was 2%–30%. Conclusion: SFT is a rare tumor which may be found in various parts of human body. SFT mostly is a benign tumor, but a few could be malignant. Its diagnosis mainly rely on its morphologic features and immunohistochemical profiles. The major treatment is to completely resect it by operation and long-term clinical follow-up is necessary.

  13. Quantification of the magnetization-transfer contrast effect: can it yield additional information in differentiation of musculoskeletal lesions particularly in separation of benign from malignant lesions; Quantifizierung des Magnetization Transfer Contrast (MTC) Effektes durch Berechnung von MT-Quotienten: Ergeben sich Zusatzinformationen fuer die Differenzierung benigner und maligner Erkrankungen des Bewegungsapparates?

    Vahlensieck, M.; Traeber, F.; Schild, H. [Radiologische Universitaetsklinik Bonn (Germany); Gieseke, J. [Philips Medizinsysteme (Germany)

    1999-12-01

    Purpose: To investigate the potential information of the amount of magnetization-transfer effect in musculoskeletal lesions and to compare MT ratios from benign and malignant musculoskeletal lesions. Material and Method: 49 patients with malignant tumors (3 osteosarcoma, 3 malignant fibrous histiocytoma, 4 chondrosarcoma, 2 Ewing sarcomas) and benign lesions (8 chondroma, 2 fibrous dysplasia, 3 osteoid-osteoma, 6 ganglion cyst, 3 cyst, 3 osteomyelitis, 4 tendinitis, 3 rotator cuff tear, 5 scar tissue) were scanned using routine MRI protocols including T{sub 1}- and T{sub 2}-weighted spin echo as well as T{sub 2}*-weighted gradient echo (FFE) sequences at 1.5 Tesla (ACS II, Philips Medical). Additionally MTC images were generated by combining the FFE sequence and the off-resonance MT technique (-1500 Hz off-resonance frequency, 1770 flip angle and 50 ms pulse duration). MT ratios were calculated as SI{sub o}-SI{sub m}/SI{sub o}. Results: The MT ratio of benign lesions was 26{+-}15%, that of malignant lesions was 22{+-}6%. The difference was statistically not significant. As expected muscle showed a high MT ratio of 50{+-}8%. Scar tissue demonstrated an MT ratio of 39{+-}16% which was significantly higher than the tumor MT ratios. Conclusion: MTC (MT ratios) failed to show significant differences between benign and malignant lesions as was expected due to basic differences in cellularity, rate of mitosis and chromatin content. MTC might however gain more importance in separating scar tissue from recurrent tumor in the future. (orig.) [German] Zielsetzung: Durch die Quantifizierung des Magnetization Transfer Contrastes sollte untersucht werden, ob sich Zusatzinformationen in der Magnetresonanztomographie des Stuetz- und Bewegungsapparates ergeben. Insbesondere sollte ermittelt werden, ob gut- und boesartige Laesionen unterschiedliche MT-Quotienten aufweisen. Material und Methode: 49 Patienten mit boesartigen Tumoren (3 Osteosarkom, 4 Chondrosarkom, 3 Malignes

  14. A case report of the fibrous dysplasia

    The author observed a rare case of fibrous dysplasia in 12 year old female who came to the Infirmary of Dental College, Seoul National University, complaining of facial asymmetry of 3 years' duration in right maxillofacial region. The serial radiograms has been taken, and the nature of the lesion established as a typical fibrous dysplasia according to the interpreted findings in their images. The author has obtained the results as follows: 1. Fibrous dysplasia occurred at 3 years of age in this case. 2. On familial tendency, traumatic history and endocrine disturbances were not noted in this patient. 3. The serial radiograms revealed a typical fibrous dysplasia encroaching right zygomatic bone.

  15. Artificial fibrous proteins: a review.

    Heslot, H

    1998-01-01

    Several kinds of natural fibrous proteins have been chosen as models: silk fibroin from Bombyx mori, silks from various species of spiders and collagens. The dragline silk of the spider Nephila clavipes is able to stretch by 30% before breaking and has a high tensile strength. It is stronger per unit weight than high tensile steel. Although the partial sequence of the two components of dragline silk is known, its molecular structure is still far from being clearly established. It is however demonstrated that it contains beta-sheet crystals composed of polyalanine residues. Artificial fibrous proteins have been prepared in vivo using either Escherichia coli or the yeast Pichia pastoris. As these proteins contain repetitive sequences, there is a risk of deletion at the DNA level. This difficulty has been solved by making use of the genetic code degeneracy. One group has successfully synthesized silk-like polymers; prolastin polymers containing both silk-like and elastin-like blocks; proNectin polymers containing the RGD triplet coming from fibronectin and able to fix numerous mammalian cell types; and synthetic collagen analogs. Some of these polymers have been spun into fibers that, up-to-now, do not display any measurable molecular orientation. Another group has studied artificial fibrous proteins able to form beta-sheet crystals of defined thickness and bearing functional groups at their surface, for instance Glu residues, selenomethionine or p-fluorophenylalanine. Apart from university laboratories, a venture capital society, an industrial research center and a US army research center are quite active in this field. A number of patents has been deposited. PMID:9587659

  16. Creep of fibrous composite materials

    Lilholt, Hans

    1985-01-01

    Models are presented for the creep behaviour of fibrous composite materials with aligned fibres. The models comprise both cases where the fibres remain rigid in a creeping matrix and cases where the fibres are creeping in a creeping matrix. The treatment allows for several contributions to the...... creep strength of composites. The advantage of combined analyses of several data sets is emphasized and illustrated for some experimental data. The analyses show that it is possible to derive creep equations for the (in situ) properties of the fibres. The experiments treated include model systems such...

  17. A constitutional de novo mutation in exon 8 of the p53 gene in a patient with multiple primary malignancies.

    Speiser, P.; Gharehbaghi-Schnell, E.; Eder, S; Haid, A.; Kovarík, J.; Nenutil, R.; Sauter, G.; Schneeberger, C. H.; Vojtesek, B.; Wiltschke, C. H.; Zeillinger, R.

    1996-01-01

    We report a constitutional point mutation of codon 278 in exon 8 of the TP53 gene that has not yet been described as a germ-line mutation. A 52-year-old female developed multiple primary malignancies (liposarcoma, breast cancer, malignant histiocytoma, occult adenocarcinoma). The mutation found in her tumour and peripheral blood lymphocyte DNA is a cytosine to thymine transition at the second position of codon 278 resulting in an amino acid exchange from proline to leucine in the DNA-binding ...

  18. 皮肤富于细胞型纤维组织细胞瘤临床病理观察%Clinicopathological features of celluar fibrous histiocytoma

    鲍天辉; 吴慰霖; 詹丽影; 程晓琳

    2013-01-01

    目的 探讨富于细胞型纤维组织细胞瘤(cFH)的临床病理特点及鉴别要点.方法 对1例细胞形态多变的cFH进行临床、病理形态及免疫组化研究,同时复习相关文献.结果 肿瘤位于左侧腋前,呈灰白色,质地偏韧.与多数文献报道的cFH典型组织学形态(高度富于梭形细胞和束状生长方式)有所不同;本例表现为圆形、卵圆形上皮样细胞密集排列,短梭形、梭形细胞相对较少,梭形细胞束状排列区不太明显.瘤细胞胞质嗜酸性,核卵圆形空泡状,有嗜酸性小核仁,可见多处透明变.核分裂象>4个/10 HPF,累及真皮网状层.免疫组化示肿瘤细胞CD163和vimentin(+),Ki-67增殖指数<5%,CD68和CD34(-).结论 该瘤可发生于全身任何部位,切除不完整,临床复发率高,可达26%,典型组织学特征为高度富于梭形细胞、束状结构和有较多的核分裂象,需要与平滑肌肉瘤及皮肤隆突性纤维肉瘤鉴别.

  19. Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma

    Kolla V, P Rasad; Aftab Taiyab; D Jyothi; Usha K Srinivas; Amere S Sreedhar

    2007-04-01

    Heat shock response is associated with the synthesis of heat shock proteins (Hsps) which is strictly regulated by different members of heat shock transcription factors (HSFs). We previously reported that a rat histiocytoma, BC-8 failed to synthesize Hsps when subjected to typical heat shock conditions (42°C, 60 min). The lack of Hsp synthesis in these cells was due to a failure in HSF1 DNA binding activity. In the present study we report that BC-8 tumor cells when subjected to heat shock at higher temperature (43°C, 60 min) or incubation for longer time at 42°C, exhibited necrosis characteristics; however, under mild heat shock (42°C, 30 min) conditions cells showed activation of autophagy. Mild heat shock treatment induced proteolysis of HSF1, and under similar conditions we observed an increase in HSF2 expression followed by its enhanced DNA binding activity. Inhibiting HSF1 proteolysis by reversible proteasome inhibition failed to inhibit heat shock induced autophagy. Compromising HSF2 expression but not HSF1 resulted in the inhibition of autophagy, suggesting HSF2 dependent activation of autophagy. We are reporting for the first time that HSF2 is heat inducible and functions in heat shock induced autophagic cell death in BC-8 tumor cells.

  20. Nutritional fibrous osteodystrophy in goats

    Paulo M Bandarra

    2011-10-01

    Full Text Available Seven out of 25 goats from a southern Brazilian flock developed nutritional fibrous osteodystrophy. Affected animals were younger than 1 year of age and were confined in stalls and fed a concentrate ration containing 1:6 calcium:phosphorus ratio. The remaining flock (35 goats was managed at pasture and showed no disease. Clinical signs were characterized by mandibular and maxillary enlargements, varying degrees of mouth opening and protruding tongue, dyspnea, apart of abnormalities of prehension and mastication. Affected animals had increased seric levels of phosphorus and parathormone, as well as higher alkaline phosphatase activity. Postmortem examination on three succumbed goats revealed bilateral enlargement of the maxilla and mandibula, and loose teeth, apart of multiple incomplete rib fractures in one of them. Severe diffuse proliferation of loose connective tissue surrounded the osteoid trabeculae, many of which were partially or completely non-mineralized. Mineralized osteoid trabeculae showed osteoclasts in the Howship's lacunae.

  1. Posttraumatic Cranial Cystic Fibrous Dysplasia

    Arata Tomiyama

    2011-01-01

    Full Text Available A 14-year-old was girl admitted to our hospital with a subcutaneous mass of the occipital head. The mass had grown for 6 years, after she had sustained a head injury at the age of 6, and was located directly under a previous wound. Skull X-ray Photograph (xp, computed tomography (CT, and magnetic resonance imaging (MRI showed a bony defect and cystic changes in the skull corresponding to a subcutaneous mass. Bone scintigraphy revealed partial accumulation. The patient underwent total removal of the skull mass, and the diagnosis from the pathological findings of the cyst wall was fibrous dysplasia (FD. The radiographic findings for cystic cranial FD can be various. Progressive skull disease has been reported to be associated with head trauma, but the relationship between cranial FD and head trauma has not been previously reported. Previous studies have suggested that c-fos gene expression is a key mechanism in injury-induced FD.

  2. Systemic therapy for selected skull base sarcomas: Chondrosarcoma, chordoma, giant cell tumour and solitary fibrous tumour/hemangiopericytoma.

    Colia, Vittoria; Provenzano, Salvatore; Hindi, Nadia; Casali, Paolo G; Stacchiotti, Silvia

    2016-01-01

    This review highlights the data currently available on the activity of systemic therapy in chondrosarcoma, chordoma, giant cell tumour of the bone (GCTB) and solitary fibrous tumour, i.e., four rare sarcomas amongst mesenchymal malignancy arising from the skull base. PMID:27330421

  3. Inflammatory pseudotumor of the spleen: A case report

    Selda SEÇKİN; Kübra YILDIRIM

    2008-01-01

    Inflammatory pseudotumors, also known as inflammatory miyofibroblastic tumors, are rare benign tumors of the spleen. The diagnosis of these tumors may be difficult, because they simulate some hematopoetic malignancies, leiomyosarcomas, inflammatory malignant fibrous histiocytoma and inflammatory fibrosclerosing lesions. They frequently occur at lung. But they are reported at gastrointestinal system, orbit, liver, bladder, lymph nodes, heart, brain, mesentery, omentum and spleen. Histologicall...

  4. Solitary Fibrous Tumor of the Kidney Developing Local Recurrence

    Wataru Usuba

    2016-01-01

    Full Text Available Solitary fibrous tumor (SFT of the kidney is a rare entity and usually displays a favorable prognosis. We herein report a second case of renal SFT developing local recurrence. A 50-year-old man was referred to our hospital because of a left renal mass. An abdominal CT detected a large renal tumor and radical nephrectomy was performed with a possible diagnosis of renal cell carcinoma. The resected tumor size was measured at 17 × 11 × 8 cm. Grossly, necrosis was observed in central lesion of the tumor but hemorrhage was not observed. Microscopically, the tumor consisted of spindle-shaped cells with scant cytoplasm accompanied by hyalinized collagenous tissue, which displayed hemangiopericytomatous patterns. The cellularity was normal and nuclear pleomorphism was not observed. Ki-67 labeling index was less than 3%. The pathological diagnosis of SFT was made without obvious malignant findings. Three years after the surgery, a follow-up CT scan detected a mass lesion in the tumor bed. Surgical resection was performed and the resected tumor was compatible with local recurrence of the SFT without obvious malignant findings. Renal SFT should be carefully monitored even in the absence of obvious malignant findings.

  5. Solitary Fibrous Tumor of the Kidney Developing Local Recurrence.

    Usuba, Wataru; Sasaki, Hideo; Yoshie, Hidekazu; Kitajima, Kazuki; Kudo, Hiroya; Nakazawa, Ryuto; Sato, Yuichi; Takagi, Masayuki; Chikaraishi, Tatsuya

    2016-01-01

    Solitary fibrous tumor (SFT) of the kidney is a rare entity and usually displays a favorable prognosis. We herein report a second case of renal SFT developing local recurrence. A 50-year-old man was referred to our hospital because of a left renal mass. An abdominal CT detected a large renal tumor and radical nephrectomy was performed with a possible diagnosis of renal cell carcinoma. The resected tumor size was measured at 17 × 11 × 8 cm. Grossly, necrosis was observed in central lesion of the tumor but hemorrhage was not observed. Microscopically, the tumor consisted of spindle-shaped cells with scant cytoplasm accompanied by hyalinized collagenous tissue, which displayed hemangiopericytomatous patterns. The cellularity was normal and nuclear pleomorphism was not observed. Ki-67 labeling index was less than 3%. The pathological diagnosis of SFT was made without obvious malignant findings. Three years after the surgery, a follow-up CT scan detected a mass lesion in the tumor bed. Surgical resection was performed and the resected tumor was compatible with local recurrence of the SFT without obvious malignant findings. Renal SFT should be carefully monitored even in the absence of obvious malignant findings. PMID:27239363

  6. Aggressive fibrous dysplasia of the maxillary sinus

    Five of 34 patients (ages 4-21 years), who were subsequently diagnosed histologically as having fibrous dysplasia of the maxillary sinus, rapidly developed soft tissue masses of the malar region over a period of less than 4 months with accompanying pain (2 patients) and nasal obstruction and exophthalmos (2 patients). Each was clinically suspected of having a sarcoma. After resection, all lesions developed regrowth. At histopathologic examination, both initial and recurrent masses proved to be typical fibrous dysplasia. (orig./UWA)

  7. Malignant mesothelioma

    Parker Robert J; Moore Alastair J; Wiggins John

    2008-01-01

    Abstract Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium) of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis. The exact prevalence is unknown but it is estimated that mesotheliomas represent less than 1% of all cancers. Its incidence is increasing, with an expected peak in the next 10–20 years. Pleural malignant mesothelioma is the most common form of mesothelioma. Typical presenting featu...

  8. Fibrous dysplasia in axis treated with vertebroplasty

    Kadir Kotil

    2010-01-01

    Full Text Available Vertebroplasty of the axis is a challenging procedure, and little is known about its therapeutic outcome. Cervical fibrous dysplasia with a distinct cyst is a rare entity and few cases have been reported in the literature. A 55-year-old man with fibrous dysplasia of axis presented with severe neck pain and left arm since six months. Computed tomography and magnetic resonance imaging revealed an expansile, destructive lesion involving the axis, and no spinal cord. He was submitted to retropharyngeal surgery and the lesion was fulled by vertebroplasty. Microscopic examination was consistent with the diagnosis of monostotic fibrous dysplasia. After the surgery no recurrence was observed. The patient had remarkable improvement in clinical relief of neck pain at 1-year follow-up. Although there are descriptions of vertebral fibrous dysplasia, this is the 13th case of monostotic fibrous dysplasia of the cervical spine, and the 3rd case of the axis described in the literature. The unique case who had treated with ope vertebroplasty.

  9. Recurrent Monostotic Fibrous Dysplasia in the Mandible

    Nilton Alves

    2016-01-01

    Full Text Available Fibrous dysplasia (FD is a condition in which normal bone marrow is replaced by an abnormal proliferation of new fibrous connective tissue. Female patient, white, 20 years old, attended the dental clinic reporting a slow increase in volume in the right mandible region over the last 5 years. She was examined by imaging: the panoramic X-ray revealed a lesion with the appearance of ground glass while the cone-beam computed tomography showed an extensive lesion in the region of the right hemimandible. The histopathological examination was compatible with fibrous dysplasia. Bone gammagraphy was indicated, plus an endocrinological study to eliminate polyostotic forms, which produced a negative result. Monostotic fibrous dysplasia in the right hemimandible was diagnosed. Conservative surgery was carried out and after 1 year recurrence of the tumour was observed. We may conclude that conservative surgery might not be the best choice for treatment for monostotic fibrous dysplasia in the mandible and that other options must be considered, such as radical surgery or the use of bisphosphonates. In our study, we may also conclude that it is very important to explain to the patient the possibility of recurrence of the lesion and the need for monitoring with periodic imaging studies.

  10. Congenital fibrous hamartoma of the knee

    Arioni, Cesare; Bellini, Carlo; Risso, Francesco Maria; Scopesi, Fabio; Serra, Giovanni [University of Genoa, Neonatal Pathology Service, Department of Paediatrics, Institute G. Gaslini, Genoa (Italy); Oddone, Mauro; Toma, Paolo [Institute G. Gaslini, Radiology Service, Genoa (Italy); Nozza, Paolo [Institute G. Gaslini, U. O. di Anatomia Patologica, Genoa (Italy)

    2006-05-15

    A full-term male infant presented at birth with a hard swelling of the left knee. The lemon-sized lesion was fixed to the underlying knee muscles, while the overlying skin was stretched and shiny; there was no bruit. Radiography, sonography and MRI suggested a soft-tissue tumour. After surgical excision, histology showed the presence of fibrous and mesenchymal tissue, with mature adipose tissue. Fibrous hamartoma of infancy was diagnosed. Among soft-tissue tumours, fibrous hamartoma of infancy is a rare and benign lesion, occurring in the first 2 years of life. The tumour mainly affects the trunk, axilla, and upper extremities. This infant had unique involvement of the knee. The treatment of choice is local excision. (orig.)

  11. Congenital fibrous hamartoma of the knee

    A full-term male infant presented at birth with a hard swelling of the left knee. The lemon-sized lesion was fixed to the underlying knee muscles, while the overlying skin was stretched and shiny; there was no bruit. Radiography, sonography and MRI suggested a soft-tissue tumour. After surgical excision, histology showed the presence of fibrous and mesenchymal tissue, with mature adipose tissue. Fibrous hamartoma of infancy was diagnosed. Among soft-tissue tumours, fibrous hamartoma of infancy is a rare and benign lesion, occurring in the first 2 years of life. The tumour mainly affects the trunk, axilla, and upper extremities. This infant had unique involvement of the knee. The treatment of choice is local excision. (orig.)

  12. Malignant hyperthermia

    Repeated or untreated episodes can cause kidney failure. Untreated episodes can be fatal. ... such as cocaine, amphetamine (speed), and ecstasy. These drugs may cause problems similar to malignant hyperthermia in people who ...

  13. Primary solitary fibrous tumor of the retroperitoneum

    Hind Charhi

    2011-12-01

    Full Text Available Solitary fibrous tumor is an uncommon neoplasm affecting adults and typically located in the pleura and can also occur in a large number of other extra thoracic sites. We present the case of a solitary fibrous tumor (SFT of the retroperitoneum and describe their histopathological and immunohistochemical features. The identification of SFT in the retroperitoneum is of importance because its clinico-pathological behaviour is still unclear. The pathologist plays a fundamental role in establishing both the positive and differential diagnosis.

  14. Angiomatoid fibrohistiocytoma - radiological findings; Fibro-histiocitoma angiomatoide - relato de um caso

    Borges, Aurea Valeria Rosa Mohana; Dinoa, Vanessa de Albuquerque; Teixeira, Sonia Marcelino [Hospital Universitario Antonio Pedro (HUAP), Niteroi, RJ (Brazil). Servico de Radiologia; Marchiori, Edson; Vianna, Alberto Domingues [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Radiologia; Morais, Heleno Pinto de [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Patologia

    1997-05-01

    The authors report a case of an 11-year-old girl with asthenia, anemia and right supraclavicular tumor. The chest roentgenogram and computed tomography showed a heterogeneous soft tissue mass with peripheral calcifications, beside the scapula. The histologic diagnosis after surgery was an angiomatoid fibrous histiocytoma. This rare type of tumor tend to occur in young adults and have a borderline feature, and it is described in the literature as a low-grade, malignant fibrous histiocytoma. the authors describe its radiological and histological findings. (author) 6 refs., 2 figs.

  15. History Of Impregnation Techniques With Fibrous Materials

    The importance of wood as a raw material is described and its deficiencies are listed. The history of the development of some impregnatio processes for fibrous materials is outlined and a hopeful prognosis for the future utilization of improved wood is made. (author)

  16. Imaging diagnosis of solitary fibrous tumors

    Objective: To discuss the feature of solitary fibrous tumor on CT and MRI. Methods: The clinical and imaging data A of 10 cases with pathologically confirmed solitary fibrous tumor analyzed retrospectively. All patients underwent un-enhanced and dual-phase enhanced CT scanning, and post-processing reconstruction were done in 7 cases. 5 cases underwent plain enhanced MRI simultaneously. Results: The tumor located in pleural in 5 cases, lung in 2 cases, retroperitoneal in 2 cases, peritoneum in 1 cases. The diameter of tumor was of 5.5-27 cm range. The boundary was clear in 8 cases not in 2 cases. The density was even in 6 cases, and with cystic necrosis in 5 cases. The solid components of tumor was homogeneous enhanced lightly to moderately with continued strengthen in parenchymal phase. Obviously enhancement was found in 1 case and calcification appeared in 1 case. Conclusion: Imaging findings solitary fibrous tumor are characteristic. CT and MRI have a great diagnostic and differential diagnostic value in solitary fibrous tumor. (authors)

  17. Solitary fibrous tumour of the spinal cord

    Mordani, J.P. [City General Hospital, Stoke-on-Trent (United Kingdom). Dept. of Radiology; Haq, I.U. [North Staffordshire Royal Infirmary, Stoke-on-Trent (United Kingdom). Dept. of Neuroradiology; Singh, J. [North Staffordshire Royal Infirmary, Stoke-on-Trent (United Kingdom). Dept. of Neurosurgery

    2000-09-01

    We report an intramedullary primary solitary fibrous tumour of the cervical spinal cord in a 33-year-old man. The tumour predominantly consisted of monomorphic spindle cells with a storiform pattern. MRI demonstrated an inhomogeneously enhancing cervical intramedullary tumour. The patient was well without recurrence 18 months after surgery. (orig.)

  18. Development of oxide fibrous monolith systems.

    Goretta, K. C.

    1999-03-02

    Fibrous monolithic ceramics generally have a cellular structure that consists of a strong cell surrounded by a weaker boundary phase [1-5]. Fibrous monoliths (FMs) are produced from powders by conventional ceramic fabrication techniques, such as extrusion [1,2]. When properly engineered, they exhibit fail gracefully [3-5]. Several compositions of ceramics and cermets have been processed successfully in fibrous monolithic form [4]. The most thoroughly investigated fibrous monolith consists of Si{sub 3}N{sub 4} cells and a BN cell-boundary phase [3-5]. Through appropriate selection of initial powders and extrusion and hot-pressing parameters, very tough final products have been produced. The resultant high toughness is due primarily to delamination during fracture along textured platelike BN grains. The primary objectives of our program are to develop: (1) Oxide-based FMs, including new systems with improved properties; (2) FMs that can be pressureless sintered rather than hot-pressed; (3) Techniques for continuous extrusion of FM filaments, including solid freeform fabrication (SFF) for net-shape fabrication of FMs; (4) Predictive micromechanical models for FM design and performance; and (5) Ties with industrial producers and users of FMs.

  19. Malignant mesothelioma

    Parker Robert J

    2008-12-01

    Full Text Available Abstract Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis. The exact prevalence is unknown but it is estimated that mesotheliomas represent less than 1% of all cancers. Its incidence is increasing, with an expected peak in the next 10–20 years. Pleural malignant mesothelioma is the most common form of mesothelioma. Typical presenting features are those of chest pain and dyspnoea. Breathlessness due to a pleural effusion without chest pain is reported in about 30% of patients. A chest wall mass, weight loss, sweating, abdominal pain and ascites (due to peritoneal involvement are less common presentations. Mesothelioma is directly attributable to occupational asbestos exposure with a history of exposure in over 90% of cases. There is also evidence that mesothelioma may result from both para-occupational exposure and non-occupational "environmental" exposure. Idiopathic or spontaneous mesothelioma can also occur in the absence of any exposure to asbestos, with a spontaneous rate in humans of around one per million. A combination of accurate exposure history, along with examination radiology and pathology are essential to make the diagnosis. Distinguishing malignant from benign pleural disease can be challenging. The most helpful CT findings suggesting malignant pleural disease are 1 a circumferential pleural rind, 2 nodular pleural thickening, 3 pleural thickening of > 1 cm and 4 mediastinal pleural involvement. Involvement of a multidisciplinary team is recommended to ensure prompt and appropriate management, using a framework of radiotherapy, chemotherapy, surgery and symptom palliation with end of life care. Compensation issues must also be considered. Life expectancy in malignant mesothelioma is poor, with a median survival of about one year following diagnosis.

  20. Solitary fibrous tumor of the pleura – analysis of 18 cases

    Pryt, Łukasz; Szlachcińska, Aleksandra; Walczak-Pasz, Grażyna; Jesionek-Kupnicka, Dorota; Kozak, Józef

    2015-01-01

    Introduction Solitary fibrous tumors of the pleura (SFTP) are primary tumors arising from mesenchymal cells. Immunohistochemical studies have demonstrated that the origin of these tumors is mesenchymal rather than mesothelial. The aim of this study is to present our experience with diagnosing and treating patients with SFTP. Material and methods We analyzed 18 patients treated at the Department of Thoracic Surgery of the Medical University of Lodz. The patients’ medical histories and the results of postoperative histopathological investigation of the tumors were analyzed. Postoperative histopathological samples were evaluated with regard to the current criteria of malignancy. Results In 17 patients, the tumors were surgically removed. Benign and small lesions (less than 3 cm in size) were removed by video-assisted thoracoscopic surgery (VATS). In 5 cases, malignant tumors were found in the postoperative material. Conclusions Solitary fibrous tumors of the pleura is a tumor with frequently asymptomatic clinical course. Treatment consists in resection which includes the adjacent structures, especially if the tumor is malignant. PMID:26702276

  1. Primary synovial sarcoma of the abdominal wall: a case report and literature review

    Kritsaneepaiboon, Supika; Sangkhathat, Surasak; Mitarnun, Winyou

    2015-01-01

    Synovial sarcoma (SS) is the fourth most common type of soft tissue sarcoma, following malignant fibrous histiocytoma, liposarcoma, and rhabdomyosarcoma. It usually occurs in the extremities near the large joints of middle-aged patients. We describe a case of synovial sarcoma of the anterior abdominal wall (SSAW) in an adolescent girl and undertake a review of the literature.

  2. Sorafenib in Treating Patients With Metastatic, Locally Advanced, or Recurrent Sarcoma

    2014-05-07

    Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Leiomyosarcoma; Adult Malignant Fibrous Histiocytoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Ovarian Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Uterine Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage III Uterine Sarcoma; Stage IV Adult Soft Tissue Sarcoma; Stage IV Uterine Sarcoma; Uterine Carcinosarcoma; Uterine Leiomyosarcoma

  3. Hematologic malignancies

    Hoogstraten, B.

    1986-01-01

    The principle aim of this book is to give practical guidelines to the modern treatment of the six important hematologic malignancies. Topics considered include the treatment of the chronic leukemias; acute leukemia in adults; the myeloproliferative disorders: polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis/agnogenic myeloid metaplasia; Hodgkin's Disease; non-Hodgkin's lymphoma; and Multiple Myeloma.

  4. Electron microprobe identification of fibrous aerosols in ambient air

    Nuclepore filters were used for sampling fibrous particles in ambient air. The fiber counting and fiber size measurements were done by means of SEM-methods. The number of fibers, distribution of fiber lengths, and diameters were plotted. The specific identification of asbestos fibers was made by electron microprobe analysis. Certain elements such as Si, Fe, Mg, Al, Mn, Ca, and Na as well as ratios such as Fe/Si and Mg/Si proved to be approximative identification factors for ambient asbestos. Not only asbestos and glass, also many other inorganic fibrous particles were found in the urban atmosphere as well as in the atmosphere of remote regions. Fibrous gypsum, fibrous ammonium sulfates, fibrous silicates, fibrous mica, and quartz were identified among these particles. Even in remote ambient air, relatively high concentrations of fibrous particles (103-104 m-3) could be measured, although the concentration of asbestos fibers were usually smaller than 102 m-3

  5. Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia

    We describe two cases of elderly women who presented hypoglycemic episodes with suppressed levels of insulin and insulin-like growth factor I. They were found to have huge malignant solitary fibrous tumor of the pleura. The tumors had rich vascularization on enhanced CT scans and showed characteristic low signal intensity on T2-weighted MR images. This paraneoplastic hypoglycemia is caused by an incompletely processed precursor of insulin-like growth factor II secreted from the tumor. Hypoglycemia and insulin suppression were resolved after removal of the tumors. (orig.)

  6. Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia

    Kim, J.H. [Dept. of Diagnostic Radiology, Chungnam National University Hospital, Taejon (Korea); Kim, J.O.; Kim, S.Y. [Dept. of Internal Medicine, Chungnam National University Hospital, Taejon (Korea); Na, M.H.; Lim, S.P. [Dept. of Thoracic Surgery, Chungnam National University Hospital, Taejon (Korea); Kim, J.M. [Dept. of Pathology, Chungnam National University Hospital, Taejon (Korea)

    2001-05-01

    We describe two cases of elderly women who presented hypoglycemic episodes with suppressed levels of insulin and insulin-like growth factor I. They were found to have huge malignant solitary fibrous tumor of the pleura. The tumors had rich vascularization on enhanced CT scans and showed characteristic low signal intensity on T2-weighted MR images. This paraneoplastic hypoglycemia is caused by an incompletely processed precursor of insulin-like growth factor II secreted from the tumor. Hypoglycemia and insulin suppression were resolved after removal of the tumors. (orig.)

  7. Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT: A Single Center Experience.

    Nicholas DeVito

    Full Text Available Solitary fibrous tumor (SFT is a mesenchymal neoplasm of fibrous origin. The 2013 WHO classification of soft tissue tumors defines malignant forms as hypercellular, mitotically active (>4 mitosis/10 high-power fields, with cytological atypia, tumor necrosis, and/or infiltrative margins. With an IRB-approved protocol, we investigated patient records and clinicopathologic data from our Sarcoma Database to describe the clinical characteristics of both benign and malignant SFT. All pathology specimens were reviewed by two pathologists. Descriptive statistics and univariate/multivariate survival analysis were performed. Patient records and Social Security Death Index were used to evaluate vital status. Of 82 patients, 47 (57% were women and 73 (89% were Caucasian. Median age was 62 years (range, 20 to 89. Thirty-two (39% patients succumbed to the disease. Primary tumor site was lung/pleura in 28 (34%, abdomen/pelvis in 23 (28%, extremity in 13 (16%, and head/neck in 9 (11% patients. Pathology was described as benign in 42 (51% and malignant in 40 (49% patients. Compared to benign SFT, malignant histology is associated with larger tumor size, higher mitotic counts, metastatic disease at diagnosis, and greater use of chemotherapy and radiation therapy. Gender, age, and tumor site were not significantly different between benign and malignant subtypes. By univariate analysis, only benign vs. malignant variant and complete resection positively impacted overall survival (P = 0.02 and P<0.0001, respectively. In the multivariable analysis of overall survival, receiving chemotherapy or not receiving surgery were two variables significantly associated with higher failure rate in overall survival: patients with chemotherapy vs. no chemotherapy (P = 0.003, HR = 4.55, with 95% CI: 1.68-12.34 and patients without surgery vs. with surgery (P = 0.005, HR = 25.49, with 95% CI: 2.62-247.57. Clear survival differences exist between benign and malignant SFT. While

  8. Nonlinear mechanics of soft fibrous materials

    Ogden, Raymond

    2015-01-01

    The book presents a state-of-the-art overview of the fundamental theories, established models and ongoing research related to the modeling of these materials. Two approaches are conventionally used to develop constitutive relations for highly deformable fibrous materials. According to the phenomenological approach, a strain energy density function can be defined in terms of strain invariants. The other approach is based on kinetic theories, which treats a fibrous material as a randomly oriented inter-tangled network of long molecular chains bridged by permanent and temporary junctions. At the micro-level, these are associated with chemical crosslinks and active entanglements, respectively. The papers include carefully crafted overviews of the fundamental formulation of the three-dimensional theory from several points of view, and address their equivalences and differences. Also included are solutions to boundary-value problems which are amenable to experimental verification. A further aspect is the elasticity...

  9. High surface area fibrous silica nanoparticles

    Polshettiwar, Vivek

    2014-11-11

    Disclosed are high surface area nanoparticles that have a fibrous morphology. The nanoparticles have a plurality of fibers, wherein each fiber is in contact with one other fiber and each fiber has a length of between about 1 nm and about 5000 nm. Also disclosed are applications of the nanoparticles of the present invention, and methods of fabrication of the nanoparticles of the present invention.

  10. Calcifying fibrous tumour: an unusual omental lesion

    Sudhakar, Sniya; Gibikote, Sridhar [Christian Medical College Hospital, Department of Radiology, Vellore, Tamil Nadu (India); Mistry, Yogesh [Christian Medical College Hospital, Department of Pathology, Vellore, Tamil Nadu (India); Dastidar, Arindam; Sen, Sudipta [Christian Medical College Hospital, Department of Pediatric Surgery, Vellore, Tamil Nadu (India)

    2008-11-15

    Calcifying fibrous tumour (CFT) is a recently described distinct clinicopathological entity characterized by calcifying lesions usually occurring in soft tissue of the extremities, trunk, axilla, pleura, mediastinum and peritoneum of children and adults. Most reported cases involving the peritoneum have been in adults. We present the imaging, surgical and pathology findings of CFT in a 7-year-old child who presented with an incidental finding of a large omental mass. (orig.)

  11. Calcifying fibrous tumour: an unusual omental lesion

    Calcifying fibrous tumour (CFT) is a recently described distinct clinicopathological entity characterized by calcifying lesions usually occurring in soft tissue of the extremities, trunk, axilla, pleura, mediastinum and peritoneum of children and adults. Most reported cases involving the peritoneum have been in adults. We present the imaging, surgical and pathology findings of CFT in a 7-year-old child who presented with an incidental finding of a large omental mass. (orig.)

  12. Aerosol filtration with metallic fibrous filters

    The filtration efficiency of stainless steel fibrous filters (BEKIPOR porous mats and sintered webs) is determined using submicronic monodisperse polystyrene aerosols. Lasers spectrometers are used for the aerosol measurements. The parameters varied are the fiber diameter, the number of layers, the aerosol diameter and the superficial velocity. Two selected types of filters are tested with polydisperse methylene blue aerosols to determine the effect of bed loading on the filter performance and to test washing techniques for the regeneration of the filter

  13. A Case of Extensive polyostotic fibrous dysplasia

    Lee, Byung Do [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Hwang, Eui Hwan; Lee, Sang Rae [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Kyunghee University, Seoul (Korea, Republic of)

    2000-06-15

    Fibrous dysplasia is a benign disorder of bone consisting of intramedullary proliferation of fibrous tissue and irregularly distributed, poorly developed bone. The disease manifests itself in the monostotic form in which only one bone is involved and the polyostotic form in which multiple bones at different sites are affected. We reported a extensive case of polyostotic fibrous dysplasia with involvement of craniofacial bones, mandible, ribs, extremities. A 18-year-old man showed remarkable right facial swelling who had been treated on right femur 3 years ago with a bone graft for pathologic fracture and he recognized facial swelling 5 years ago. Extraoral radiograms and computed tomogram showed diffuse sclerosis with a ground glass appearance of the most calvarial bones, facial bones. The right mandibular lesion showed very expansible lesion with mottled appearance. Bone scans showed multifocal increased uptakes in craniofacial bones, right mandible, bilaterally in ribs, humerus, femur, tibia and characteristic various deformity of right femur (shepherd's crook deformity). This case showed exceptionally bilateral, extensive nature of bone lesion and didn't show any features of skin pigmentation and endocrine disturbances.

  14. A Case of Extensive polyostotic fibrous dysplasia

    Fibrous dysplasia is a benign disorder of bone consisting of intramedullary proliferation of fibrous tissue and irregularly distributed, poorly developed bone. The disease manifests itself in the monostotic form in which only one bone is involved and the polyostotic form in which multiple bones at different sites are affected. We reported a extensive case of polyostotic fibrous dysplasia with involvement of craniofacial bones, mandible, ribs, extremities. A 18-year-old man showed remarkable right facial swelling who had been treated on right femur 3 years ago with a bone graft for pathologic fracture and he recognized facial swelling 5 years ago. Extraoral radiograms and computed tomogram showed diffuse sclerosis with a ground glass appearance of the most calvarial bones, facial bones. The right mandibular lesion showed very expansible lesion with mottled appearance. Bone scans showed multifocal increased uptakes in craniofacial bones, right mandible, bilaterally in ribs, humerus, femur, tibia and characteristic various deformity of right femur (shepherd's crook deformity). This case showed exceptionally bilateral, extensive nature of bone lesion and didn't show any features of skin pigmentation and endocrine disturbances.

  15. Collecting of Hanji fibrous sludge with surfactant

    Choi, H.S.; Kim, T.J. [The University of Suwon, Suwon (Korea)

    2001-04-01

    The technique that could collect efficiently the hanji fibrous sludge from wastewater using surfactants was developed. When fibrous sludge of which concentration was about 80 mg/L, was floated and collected, the optimum concentration of sodium oleate, the pore size of glass filter and the air flow rate were 10 mg/L, 5-10 {mu}m and 200 mL/min., respectively. The behavior of sodium oleate might be interfered by polyvalent cations such as Ca{sup 2+}. But when the concentration of Ca{sup 2+} was less than 100 mg/L, the interference effect did not appear. And when a typical cationic surfactant, cetyltrimethylammonium bromide (CTAB), was used, the collecting yield was less than of sodium oleate, and the amount of foam was higher than sodium oleate. When 1 mg/L of CTAB was added to the hanji sludge sample contained 1 mg/L of PAMID, a dispersant, fibrous sludge was effectively coagulated, the flotation time was very short and the collecting yield was above 95%. But in this case, sodium oleate was inefficient. (author). 8 refs., 6 figs.

  16. Monostotic fibrous dysplasia of the lumbar spine.

    Avimadje, A M; Goupille, P; Zerkak, D; Begnard, G; Brunais-Besse, J; Valat, J P

    2000-01-01

    Monostotic fibrous dysplasia is exceedingly rare. We report a case in a 61-year-old woman with a history of recurrent low back pain and sciatica since 35 years of age. While walking, she suddenly experienced pain in her right thigh. The pain spread gradually to the buttock and calf on the same side, becoming increasingly severe. The time pattern was mechanical, with exacerbation during straining. Paresthesia developed over the dorsal aspect of the right foot. Nonsteroidal antiinflammatory drugs were ineffective. Radiographs of the spine showed an expansile and heterogeneous lesion in the body of L2. Hyperactivity of L3 and L4 was seen on the bone scan. Computed tomography demonstrated heterogeneity of L2, L3, and L4, as well as hypertrophy of the neural arch of L3 and of the right posterior lamina and spinous process of L4. Alterations in L2, L3, and L4 were noted on the magnetic resonance imaging study, which showed no evidence of epidural involvement. Laboratory tests were normal. A surgical biopsy of L3 established the diagnosis of fibrous dysplasia. Since the seminal description of fibrous dysplasia in 1891, only 21 cases of monostotic spinal involvement have been published. The spinal lesions can remain clinically silent or cause spinal pain with or without neurological symptoms. Radiographic findings are variable (heterogeneity, osteolysis, expansion without cortical violation or soft tissue involvement). Calcium and phosphate levels are normal. The diagnosis depends on examination of a vertebral biopsy specimen. PMID:10773971

  17. Toxicity and Carcinogenicity Mechanisms of Fibrous Antigorite

    Michael Balazy

    2007-03-01

    Full Text Available We studied the effects of fibrous antigorite on mesothelial MeT-5A and monocyte-macrophage J774 cell lines to further understand cellular mechanisms induced by asbestos fibers leading to lung damage and cancer. Antigorite is a mineral with asbestiform properties, which tends to associate with chrysotile or tremolite, and frequently occurs as the predominant mineral in the veins of several serpentinite rocks found abundantly in the Western Alps. Particles containing antigorite are more abundant in the breathing air of this region than those typically found in urban ambient air. Exposure of MeT-5A and J774 cells to fibrous antigorite at concentrations of 5-100 μg/ml for 72 hr induced dose-dependent cytotoxicity. Antigorite also stimulated the ROS production, induced the generation of nitrite and PGE2. MeT-5A cells were more sensitive to antigorite than J774 cells. The results of this study revealed that the fibrous antigorite stimulates cyclooxygenase and formation of hydroxyl and nitric oxide radicals. These changes represent early cellular responses to antigorite fibers, which lead to a host of pathological and neoplastic conditions because free radicals and PGE2 play important roles as mediators of tumor pathogenesis. Understanding the mechanisms of the cellular responses to antigorite and other asbestos particles should be helpful in designing rational prevention and treatment approaches.

  18. Intramuscular myxoma and fibrous dysplasia of bone - Mazabraud's syndrome

    We present a case of Mazabroud's syndrome, a rare benign disease, with multiple intramuscular myxomas of the thoracic wall associated with fibrous dysplasia of bone. CT, MR imaging and ultrasonography (US) of the thorax showed 2 well circumscribed homogeneous intramuscular tumors. A US-guided needle biopsy with a large-core needle (2.0 mm) and a fine needle (0.8 mm) showed that the tumors were intramuscular myxomas with no sign of malignancy. 99mTc bone scintigraphy showed a markedly increased uptake in the right lower skull, and multiple smaller foci. CT of the skull revealed a right-sided unilateral bone thickening of the orbit and the ethomoidal cells, and right-sided exophthalmia. This case history suggests that patients with multiple intramuscular myxomas should be preoperatively examined for osseous lesions. A postoperative follow-up should also be performed to detect other soft-tissue myxomas not as yet clinically detectable, or rare osseous complications. (orig.)

  19. Fibrous Hamartoma of Infancy, Report of Two Cases

    Ahmad Bazrafshan

    2008-05-01

    Full Text Available Objective: Fibrous hamartoma of infancy (FHI is a rare, benign soft tissue tumor that typically occurs within the first two years of life. It has a specific histologic appearance comprising of three different mesenchymal tissues with variable proportions in an organoid fashion. The clinical course is typically benign with excellent prognosis. We report two cases of this rare lesion and review its cilinicopathologic characteristics. Case(s Presentation: The first case was a 15-month-old girl who had a subcutaneous mass in the right axillary region and the other one was an 18-month-old boy with a mass on the medial surface of his right ankle. The masses were successfully excised. After 6 and 30 months follow up no recurrence occurred. Conclusion: Although the clinical and imaging findings of FHI are quite similar to those of malignant soft tissue tumor, histologic characteristics of this tumor will guide to the definite diagnosis that will prevent aggressive and mutilating procedures.

  20. Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma

    2014-08-26

    Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Rhabdomyosarcoma; Adult Synovial Sarcoma; Gastrointestinal Stromal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Adult Soft Tissue Sarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

  1. Study of plutonium adsorption by fibrous adsorbent

    Japan Atomic Energy Research Institute and Unitika Ltd. have been conducting, under a joint effort, development of an inorganic fibrous adsorbent (FAC), which is capable of adsorbing plutonium (Pu) contained in radioactive liquid waste and which is also able to contribute to reduction of the volume of α-waste by incineration. The fibrous adsorbent constitutes fibrous activated carbon of coal tar pitch derivative and has the following characteristics: (1) It has a large surface area. (2) Carbon constitutes more than 90% in the adsorbent; it is physically and chemically stable as an inorganic adsorbent; it is easy to be incinerated. (3) It is easy to be formed or molded into different shapes such as cartridges, and handling of the material is extremely easy. By using various kinds of Pu solution, we carried out tests and evaluations on the equilibrium adsorption quantity of Pu by the fibrous adsorbent, the adsorption property of the material by flow-through column test and the incineration property of the material in the cold test. The tests show that: (1) adsorption of Pu is the best with 0.8∼0.9 mg-Pu/g-FAC when the concentration of nitric acid is near 1 M; (2) as the concentration of nitric acid is increased, its adsorption capacity becomes poorer; (3) when Pu coexists with Uranium (U), the adsorption capacity becomes slightly inferior; (4) in the flow-through column test, no breakthrough of Pu was observed until the volume of Pu liquid becomes about 3 times larger than the column volume; (5) in the incineration tests in the cold test using a laboratory scale incinerator, no flying of particles or soot was observed; and (6) it is possible to get good incineration at 500 ∼ 600 degrees C. The above results show that, by using the fibrous adsorbent, it became possible to remove Pu from radioactive liquid waste by adsorption, to reduce the volume only to residual ash by incineration, and to reduce substantially the volume of α-waste

  2. Solitary Fibrous Tumor of the Lower Leg: A Rare and Difficult Diagnosis.

    D'Arpa, Salvatore; Rossi, Matteo; Montesano, Luigi; Florena, Ada Maria; Moschella, Francesco; Cordova, Adriana

    2015-10-01

    Solitary fibrous tumor (SFT) is a rare neoplasm that commonly originates in the pleura. Extrapleural locations are rare and for this reason sometimes difficult to diagnose. Malignant forms with local recurrence or distant metastases have been reported, also as a consequence of inappropriate treatment. In this article, we report the case of an SFT of the lower leg in a 37-year-old man. Leg SFT is a rare occurrence, and differential diagnosis may be difficult because they can mimic a variety of benign and malignant mesenchymal tumors; immunohistochemical analysis for CD34, CD99, vimentin, and Bcl-2 is necessary. Misdiagnosis carries a significant risk of inadequate removal with subsequent increased risk of recurrence and distant metastases. PMID:26579334

  3. Integrally calcified solitary fibrous tumor in the retroperitoneum: a case report and review of the literature.

    Maki, Takehiro; Fujino, Syotaro; Misu, Kenjiro; Kaneko, Hiroyuki; Inomata, Hitoshi; Omi, Makoto; Tateno, Masatoshi; Nihei, Kazuyoshi

    2016-12-01

    Solitary fibrous tumor (SFT) is a rare stromal neoplasm and usually occurs in the thoracic cavity. We here report a case of retroperitoneal SFT with prominent calcification. A 64-year-old man presented with an incidentally detected retroperitoneal mass in the right upper abdomen. Imaging tests indicated an integrally calcified mass. The lesion was observed for 2 years and laparoscopically resected according to the patient's wish. Microscopically, the mass was mostly occupied by calcification and proliferous spindle cells were scattered with positive CD34 expression. We diagnosed morphologically benign SFT and the patient remained disease-free 1 year after the excision. There has been no report of such integrally calcified SFT. Retroperitoneal SFT is difficult to make a preoperative diagnosis, and careful follow-up after the excision is recommended because morphological malignancy does not always correspond to clinical malignancy. PMID:26943690

  4. Fibrous composites comprising carbon nanotubes and silica

    Peng, Huisheng; Zhu, Yuntian Theodore; Peterson, Dean E.; Jia, Quanxi

    2011-10-11

    Fibrous composite comprising a plurality of carbon nanotubes; and a silica-containing moiety having one of the structures: (SiO).sub.3Si--(CH.sub.2).sub.n--NR.sub.1R.sub.2) or (SiO).sub.3Si--(CH.sub.2).sub.n--NCO; where n is from 1 to 6, and R.sub.1 and R.sub.2 are each independently H, CH.sub.3, or C.sub.2H.sub.5.

  5. Malignant thymoma.

    Wang, L S; Huang, M H; Lin, T S; Huang, B S; Chien, K Y

    1992-07-15

    Sixty-one patients underwent operations for malignant thymomas between 1961 and 1989. Twenty-three patients had associated myasthenia gravis (MG), an incidence of 37.7%. Upon being admitted to the hospital, the patients' most common symptoms included chest pain, MG, cough, and dyspnea. Only 7 of 61 (11.5%) patients had no symptom. Tumor staging of 58 patients with invasive thymomas was performed according to Masaoka classification. The patients were classified as follows: Stage II disease, 5; Stage III, 41; Stage IVa, 8; and Stage IVb, 4. In addition, thymic carcinoma was present in three patients. The series had a resection rate of 55.7%. The incidence of operative complications was 16.3%. Only one patient died of myocardial infarction; the incidence of operative mortality was 1.6%. The patients with MG had a higher rate of resection (69.6%) and a higher incidence of complete thymectomy (14 of 23 patients; 60.9%). Mixed lymphoepithelial tumors and epithelial cell predominant tumors were the most frequent histologic patterns (45.9% and 34.4%, respectively). Fifty-two patients had postoperative radiation therapy, and 10 patients had chemotherapy. The overall cumulative survival rates in the series were 59% and 34% at 5 and 10 years, respectively. The results demonstrated that the factors affecting the prognosis may include resectability, postoperative irradiation or chemotherapy, MG, and tumor staging. The influence of histologic variation on survival rates could not be clearly defined in the series. Surgical resection, particularly complete thymectomy, followed by irradiation is the primary option of therapeutic management for malignant thymoma. PMID:1617594

  6. Malignant melanoma of nose

    Kundu, I. N.; Haldar, B.; Saha, A. K.

    2001-01-01

    Malignant melanoma (MM) is one of the uncommon malignancies of the nose. We present an unusually big proliferative like MM in the vestibule of the nose. Malignancy of nose constitutes less than 1% of all malignancies (3% of head & neck tumour). MM however contributes only 2% of all malignant neoplasms of the nose (Moore & Martin. 1955).

  7. Epithelioid malignant mesothelioma of tunica vaginalis with deciduoid features: An unusual malignancy clinically masquerading an inguinal hernia

    Sharique Ahmed

    2012-01-01

    Full Text Available Paratesticular/scrotal and inguinal canal mass lesions in elderly patients may pose a diagnostic challenge to both the surgeon as well as the pathologist. In most cases, these represent hernial sacs with their contents, and true neoplasms like lipomas, rhabdomyosarcomas, and fibrous pseudotumors are infrequent. Malignant mesotheliomas arising from the tunica layers are rare cause of inguinal and paratesticular tumors. Herein, we report a case of an elderly patient who presented with an inguinal hernia which pathologically had features of deciduoid malignant mesothelioma.

  8. Marfan syndrome with multiseptate pneumothorax and mandibular fibrous dysplasia

    Kate A

    2009-01-01

    Full Text Available We describe a rare case of pneumothorax due to Marfan syndrome associated with fibrous dysplasia of the mandible. Marfan syndrome and fibrous dysplasia were possibly due to a common etiological factor. The association between the two and other tumors described in literature related to Marfan syndrome is discussed.

  9. Marfan syndrome with multiseptate pneumothorax and mandibular fibrous dysplasia

    Kate A; Gothi D; Joshi J

    2009-01-01

    We describe a rare case of pneumothorax due to Marfan syndrome associated with fibrous dysplasia of the mandible. Marfan syndrome and fibrous dysplasia were possibly due to a common etiological factor. The association between the two and other tumors described in literature related to Marfan syndrome is discussed.

  10. Fibrous monoliths: Economic ceramic matrix composites from powders [Final report

    Rigali, Mark; Sutaria, Manish; Mulligan, Anthony; Creegan, Peter; Cipriani, Ron

    1999-05-26

    The project was to develop and perform pilot-scale production of fibrous monolith composites. The principal focus of the program was to develop damage-tolerant, wear-resistant tooling for petroleum drilling applications and generate a basic mechanical properties database on fibrous monolith composites.

  11. What Is Malignant Mesothelioma?

    ... space in the chest containing the lungs. The peritoneum lines the inside of the abdomen and many ... cancerous. A similar condition that starts in the peritoneum is called solitary fibrous tumor of the peritoneum . ...

  12. Symptomatic fibrous lunato-triquetral coalition

    Staebler, A.; Glaser, C.; Reiser, M. [Department of Diagnostic Radiology, Ludwig Maximilians University of Munich (Germany); Resnick, D. [Department of Radiology, Veterans Administration Medical Center, San Diego, CA (United States)

    1999-10-01

    In general, carpal coalitions are considered to be asymptomatic. Incomplete separated joints and associated changes similar to osteoarthritis and pseudoarthrosis are known as possible causes of wrist pain. We present the clinical history, plain-film, and MR imaging findings of two patients with symptomatic fibrous lunato-triquetral coalition. Conventional films disclosed a narrowed space between the lunate and triquetral bone with cysts and sclerosis similar to pseudoarthrosis. Magnetic resonance imaging showed bone marrow edema adjacent to the incomplete separated lunato-triquetral joint and Gd-DTPA enhancing fibrovascular tissue in the synovium and subarticular cysts, explaining the pain over the ulnar-sided wrist. Patients with congenital lunato-triquetral coalition may poorly tolerate stress loading or trauma, resulting in a symptomatic state similar to degenerative arthritis or pseudoarthrosis, which is demonstrated by enhanced MR imaging. (orig.) With 2 figs., 23 refs.

  13. A solitary fibrous tumor of the kidney

    Anuruddha M Abeygunasekera

    2015-01-01

    Full Text Available A solitary fibrous tumor (SFT is an uncommon spindle cell neoplasm that usually occurs in the pleura, but may occur in extrapleural sites. Its occurrence in the kidney is rare. We report a SFT, clinically thought to be a renal cell carcinoma arising in the kidney of a 68-year-old female. The tumor was well-circumscribed and composed of a mixture of spindle cells and dense collagenous bands. Immunohistochemical studies revealed reactivity for CD34, CD99, and Bcl-2 protein, with no staining for keratin or muscle markers, confirming the diagnosis. The immunohistochemical study was the key to diagnosis. Several younger members of her family had colorectal and lung cancers suggesting the possibility of a familial or genetic susceptibility.

  14. Nonlinear analysis of laminated fibrous composites

    A computerized analysis of the nonlinear behavior of fibrous composite laminates including axial loading, thermal loading, temperature dependent properties, and edge effects is presented. Ramberg--Osgood approximations are used to represent lamina stress--strain behavior, and percent retention curves are employed to model the variation of properties with temperature. Balanced, symmetric laminates comprised of either boron/epoxy, graphite/epoxy, or borsic--aluminum are analyzed using a quasi-three-dimensional finite element analysis. Results are presented for the interlaminar stress distributions in cross-ply, angle-ply, and more complex laminates. Nonlinear stress--strain curves for a variety of composite laminates in tension and compression are obtained and compared to other existing theories and experimental results

  15. Malignant lymphoma

    This paper describes the background and treatment, especially focusing on radiotherapy (RT), of stage I-II malignant lymphoma (ML) occurring in head and neck. For diffuse large B-cell lymphoma, the most frequently occurring ML in Japan (about 40% of all MLs), the current standard protocol involves 3 cycles of chemotherapy (CT) like rituximab to cyclophosphamide/doxorubicin/vincristine/predonisolone (CHOP) regimen followed by RT. Authors use the dose around 30 Gy/15 fr for CR patients after CHOP and 40-50 Gy/20-25 fr for PR ones. Recurrence scarcely occurs in the RT target region. However, significance of RT is still somehow controversial in this ML and addition of CHOP is currently noted. Mucosa-associated lymphoid tissue lymphoma (8.45% of Japanese ML) occurs mainly in glands and orbit and may be related with Chlamydia infection. RT is usually conducted to the whole organ with lesion as the clinical target with fractionated 30 Gy. Nasal NK/T cell lymphoma (2.6%), possibly associated with Epstein-Barr (EB) virus, is usually resistant to CHOP. Recommended is CT after RT with the dose of 50-54 Gy and depending on the target site, advanced RT like intensity-modified one is desirable. Hodgkin lymphoma (about 5%) occurs in lymph node and is derived from B-lymphocyte. Irradiation field involves the region of the disease node or that additionally including its neighbors and doses of about 20 Gy and 30 Gy are given in child and adult patients, respectively. For follicular and other tissue type lymphomas, noted are novel therapies like rituximab-combined CT, immuno-RT with 90Y-ibritumomab and 131I-tositumomab. Recently, positron emission tomography (PET) is essential for treatment assessment of the clinical response of ML in the guideline. (R.T.)

  16. Intermediate filament proteins and actin isoforms as markers for soft tissue tumor differentiation and origin. I. Smooth muscle tumors.

    Schürch, W.; Skalli, O.; Seemayer, T. A.; Gabbiani, G.

    1987-01-01

    A series of 3 benign and 10 malignant smooth muscle (SM) neoplasms and of 2 malignant fibrous histiocytomas was examined by light microscopy, transmission electron microscopy, two-dimensional gel electrophoresis (2D-GE) and indirect immunofluorescence, using polyclonal monospecific or monoclonal antibodies to desmin, vimentin, cytokeratin, alpha-SM and alpha-sarcomeric (alpha-SR) actins. Benign neoplasms displayed typical light-microscopic features of SM, whereas leiomyosarcomas demonstrated ...

  17. Consolidation of massive bone allografts in limb-preserving operations for bone tumours

    San-Julian, M.; Leyes, M.; Mora, G. (Gonzalo); Cañadell, J.M. (J. M.)

    1995-01-01

    This study analysed the influence of several factors affecting the consolidation time of 83 massive bone allografts in 79 patients with malignant bone tumours: osteosarcoma 57; Ewing's sarcoma 8; malignant fibrous histiocytoma 3; chondrosarcoma 4; fibrosarcoma 5; and giant cell tumours 2. The mean age of the patients was 19 years and the mean length of the allografts was 18 cm. The minimum follow up was for 12 months. The mean consolidation time for metaphyseal and diaphyseal osteotomies was ...

  18. Cytomorphology of epithelioid sarcoma: A diagnostic enigma

    Yogesh K Yadav

    2012-01-01

    Full Text Available Epithelioid sarcoma is an uncommon soft tissue malignancy with a known propensity for recurrence as well as metastasis. We report epithelioid sarcoma in 50 year old male with a recurrent ulcerative nodule over the right ankle since five months, initially misdiagnosed as malignant fibrous histiocytoma. The article aims at assessing the key cytological features of epithelioid sarcoma and their reliability in the diagnosis of the lesion. Also described are its histopathological and immunohistochemical features.

  19. Numerical modeling of experimental human fibrous cap delamination.

    Leng, Xiaochang; Davis, Lindsey A; Deng, Xiaomin; Sutton, Michael A; Lessner, Susan M

    2016-06-01

    Fibrous cap delamination is a critical process during the rupture of atherosclerotic plaque, which often leads to severe life-threatening clinical consequences such as myocardial infarction or stroke. In this study a finite element modeling and simulation approach is presented that enables the study of fibrous cap delamination experiments for the purpose of understanding the fibrous cap delamination process. A cohesive zone model (CZM) approach is applied to simulate delamination of the fibrous cap from the underlying plaque tissue. A viscoelastic anisotropic (VA) model for the bulk arterial material behavior is extended from existing studies so that the hysteresis phenomenon observed in the fibrous cap delamination experiments can be captured. A finite element model is developed for the fibrous cap delamination experiments, in which arterial layers (including the fibrous cap and the underlying plaque tissue) are represented by solid elements based on the VA model and the fibrous cap-underlying plaque tissue interface is characterized by interfacial CZM elements. In the CZM, the delamination process is governed by an exponential traction-separation law which utilizes critical energy release rates obtained directly from the fibrous cap delamination experiments. A set of VA model parameter values and CZM parameter values is determined based on values suggested in the literature and through matching simulation predictions of the load vs. load-point displacement curve with one set of experimental measurements. Using this set of parameter values, simulation predictions for other sets of experimental measurements are obtained and good agreement between simulation predictions and experimental measurements is observed. Results of this study demonstrate the applicability of the viscoelastic anisotropic model and the CZM approach for the simulation of diseased arterial tissue failure processes. PMID:26897094

  20. Malignant hyperthermia

    Pollock Neil

    2007-04-01

    Full Text Available Abstract Malignant hyperthermia (MH is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stresses such as vigorous exercise and heat. The incidence of MH reactions ranges from 1:5,000 to 1:50,000–100,000 anesthesias. However, the prevalence of the genetic abnormalities may be as great as one in 3,000 individuals. MH affects humans, certain pig breeds, dogs, horses, and probably other animals. The classic signs of MH include hyperthermia to marked degree, tachycardia, tachypnea, increased carbon dioxide production, increased oxygen consumption, acidosis, muscle rigidity, and rhabdomyolysis, all related to a hypermetabolic response. The syndrome is likely to be fatal if untreated. Early recognition of the signs of MH, specifically elevation of end-expired carbon dioxide, provides the clinical diagnostic clues. In humans the syndrome is inherited in autosomal dominant pattern, while in pigs in autosomal recessive. The pathophysiologic changes of MH are due to uncontrolled rise of myoplasmic calcium, which activates biochemical processes related to muscle activation. Due to ATP depletion, the muscle membrane integrity is compromised leading to hyperkalemia and rhabdomyolysis. In most cases, the syndrome is caused by a defect in the ryanodine receptor. Over 90 mutations have been identified in the RYR-1 gene located on chromosome 19q13.1, and at least 25 are causal for MH. Diagnostic testing relies on assessing the in vitro contracture response of biopsied muscle to halothane, caffeine, and other drugs. Elucidation of the genetic changes has led to the introduction, on a limited basis so far, of genetic testing for susceptibility to MH. As the sensitivity of genetic testing increases, molecular genetics will be used for identifying those at risk with

  1. Ehlers-Danlos syndrome with monostotic fibrous dysplasia

    Rao A

    1979-01-01

    Full Text Available An unusual case of Ehlers-Danlos syndrome with monostotic fibrous dysplasia of the humorus is presented. The other orthopae-dic manifestations, its complications and associated features are re-viewed and summarised.

  2. Localised fibrous mesothelioma arising in an intralobar pulmonary sequestration.

    Paksoy, N.; Demircan, A.; Altiner, M; Artvinli, M

    1992-01-01

    A localised fibrous mesothelioma arising from an intralobar lung sequestration occurred in a 64 year old Turkish woman. This appears to be the first report of a mesothelioma occurring within a pulmonary sequestration.

  3. Solitary fibrous tumor of the liver expressing CD34 and vimentin: A case report

    Dimitris P Korkolis; George N Zografos; Perikles P Vassilopoulos; Katerina Apostolaki; Chrysanthi Aggeli; George Plataniotis; Emmanuel Gontikakis; Dimitra Volanaki; Maria Sebastiadou; Dimitris Dimitroulopoulos; Dimitris Xinopoulos

    2008-01-01

    A case of a successfully treated solitary fibrous tumor(SFT) of the liver is reported. An 82-year-old femalepresented with left upper abdominal discomfort, afirm mass on palpation, and imaging studies revealeda large tumor, 15 cm in diameter, arising from theleft lobe of the liver. A formal left hepatectomy wasperformed. Microscopic evaluation showed spindleand fibroblast-like cells within the collagenous stroma.Immunohistochemistry disclosed diffuse CD34 andpositive vimentin, supporting the diagnosis of abenign SFT. The patient remained well 21 monthsafter surgery. SFT of the liver is a very rare neoplasmof mesenchymal origin. In most cases it is a benignlesion, although some may have malignant histologicalfeatures and recur locally or metastasize. With lessthan 30 reported cases in the literature, little canbe said regarding its natural history or the benefitsof adjuvant radiochemotherapy. Complete surgicalresection remains the cornerstone of its treatment.

  4. Impregnated Fibrous Materials. Report of a Study Group on Impregnated Fibrous Materials

    There has recently been renewed interest in the use of radiation from radioisotopes or particle accelerators to initiate and sustain chemical reactions. Particular attention is being paid to the production of wood-plastic composites, a process which is now a commercial reality with radiation competing against chemical methods to enhance the properties of wood. It has been reported that water repellancy, hardness, weathering, insect and chemical resistance, compressive, bending and shear strength can be significantly improved by the process, but so far there has been a limited commercial outlet for the product. Papers on this subject were presented at the International Atomic Energy Agency's Symposium on Industrial Uses of Large Radiation Sources, Salzburg, May 1963, and since then the Agency has been aware of the interest of developing countries in conducting research on wood and other fibrous materials as a means of further exploiting natural resources. It was felt that some attempt should be made to co-ordinate, on a regional basis, the work being done in this field and at the same time review the world status, including the associated technology in such areas as monomer-polymer chemistry and impregnation techniques where they are directly related to this work. Because of the wide range of fibrous materials being studied there, Asia and the Far East was chosen as the most representative area and 39 participants from 13 countries, and from international organizations, met in Bangkok from 20 to 24 November 1967 to assess the potential of impregnated fibrous materials. This report is a record of the meeting and is based not only on work performed both inside and outside the region but also on details of the resources and industries in the area

  5. Three-Dimensional Multilayered Fibrous Constructs for Wound Healing Applications

    Reis, Tiago C.; Castleberry, Steven; Rego, Ana M. B.; Aguiar-Ricardo, Ana; Hammond, Paula T.

    2016-01-01

    Electrospun materials are promising scaffolds due to their light-weight, high surface-area and low-cost fabrication, however, such scaffolds are commonly obtained as ultrathin two-dimensional non-woven meshes, lacking on topographical specificity and surface side-dependent properties. Herein, it is reported the production of three-dimensional fibrous materials with an asymmetrical inner structure and engineered surfaces. The manufactured constructs evidence fibrous-based microsized conical pr...

  6. Effects of compression on the sound absorption of fibrous

    Castagnede, Bernard; Akninen, Achour; Brouard, Achour;

    2000-01-01

    During the compression of a fibrous mat, it is well known that the absorption properties are decreasing. In order to predict this change, some heuristic formulae are proposed which take into account the modifications of the physical parameters(porosity, resistivity, tortousity and shappe factors)......) which enter in the standard "equivalent fluid" model. Numerical predictions are then discussed and compared to experimental data obtained on a fibrous material(uncompressed and the compressed) used in automotive industry....

  7. Giant solitary fibrous tumour of the liver

    Eggermont Alexander MM

    2006-11-01

    Full Text Available Abstract Background Solitary fibrous tumour (SFT is an uncommon mesenchymal neoplasm that most frequently affects the pleura, although it has been reported with increasing frequency in various other sites such as in the peritoneum, pericardium and in non-serosal sites such as lung parenchyma, upper respiratory tract, orbit, thyroid, parotid gland, or thymus. Liver parenchyma is rarely affected. Clinically, SFTs cause symptoms after having reached a certain size or when vital structures are involved. In recent years, SFTs are more often identified and distinguished from other tumours with a similar appearance due to the availability of characteristic immunohistochemical markers. Case presentation In this manuscript we report the case of a large tumour of the liver, which was histologically diagnosed as a SFT, and showed involvement of a single hepatic segment. Because of the patient's presentation and clinical course, it may represent a radiation-induced lesion. Conclusion When a SFT has been diagnosed, surgery is the treatment of choice. The small number of patients with a SFT of the liver and its unknown natural behaviour creates the need to a careful registration and follow-up of all identified cases

  8. Hierarchically engineered fibrous scaffolds for bone regeneration

    Sachot, Nadège; Castaño, Oscar; Mateos-Timoneda, Miguel A.; Engel, Elisabeth; Planell, Josep A.

    2013-01-01

    Surface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopographic cues, for example, influence cell proliferation and differentiation. Here, we present a novel coating protocol to produce hierarchically engineered fibrous scaffolds with tailorable surface characteristics, which mimic bone extracellular matrix. Based on the sol–gel method and a succession of surface treatments, hollow electrospun polylactic acid fibres were coated with a silicon–calcium–phosphate bioactive organic–inorganic glass. Compared with pure polymeric fibres that showed a completely smooth surface, the coated fibres exhibited a nanostructured topography and greater roughness. They also showed improved hydrophilic properties and a Young's modulus sixfold higher than non-coated ones, while remaining fully flexible and easy to handle. Rat mesenchymal stem cells cultured on these fibres showed great cellular spreading and interactions with the material. This protocol can be transferred to other structures and glasses, allowing the fabrication of various materials with well-defined features. This novel approach represents therefore a valuable improvement in the production of artificial matrices able to direct stem cell fate through physical and chemical interactions. PMID:23985738

  9. Ultrasonographic features of fibrous hamartoma of infancy

    To review imaging features of fibrous hamartoma of infancy (FHI), focusing on ultrasonography (US) findings. We retrospectively reviewed pediatric patients who were diagnosed with pathologically confirmed FHI in two children's hospitals from 2004 to 2013. Imaging features of US, Doppler US, and magnetic resonance imaging (MRI) were evaluated. Thirteen pediatric patients (M:F = 7:6; age 5-22 months, mean 11.3 months) were included. Mean lesion size was 3.2 cm (range, 0.7-8.0 cm). The tumors were located in the back (n = 4), scrotum (n = 2), scalp, shoulder, axilla, forearm, intergluteal cleft, inguinal area, and thigh. US was performed in 11 patients. With the exception of two scrotal masses, all masses were located in the dermal and subcutaneous layer. All masses demonstrated heterogeneous hyperechogenicity with a ''serpentine pattern'' of intervening hypoechoic portions in the hyperechoic mass. The margins were ill-defined (n = 9) or lobulated (n = 2). Doppler US was performed in nine patients and showed no (n = 6) or minimal (n = 3) vascularity. MRI was performed in five patients and the masses showed heterogeneous signal intensity with the presence of fat on T1- and T2-weighted images. FHI is a tumor that is typically located in the dermal and subcutaneous layer in young children less than 2 years old and presents as a heterogeneously hyperechoic mass with a ''serpentine pattern'' and ill-defined or lobulated margin on US and no remarkable vascularity on Doppler US. (orig.)

  10. Malignant lymphoma in central nervous system (CNS)

    A 71-year-old male was admitted to Kohka Public Hospital on January 4, 1980, because of frequent vomiting and recent memory loss. Two weeks before admission upper G-I series showed no abnormalities. Physical and neurological examinations revealed no abnormalities except for slightly apathetic appearance and recent memory loss. Mild pleocytosis and marked increase of protein in CSF were observed. CT scan on January 17 showed high density areas in both medial sides of temporal lobes with remarkable contrast enhancement. His memory and, consciousness disturbances gradually aggravated, accompanied by abnormal density spreading around the ventricle walls like ventriculitis. He was transfered to Kyoto University Hospital on March 17, and malignant lymphoma was diagnosed on the basis of CSF cytology. Radiation and chemotherapy alleviated the CNS involvement and he regained normal mental function. On June 16, he developed pneumonia followed by status epilepticus. Autopsy findings revealed no lymphoid cell infiltration, but fibrous tissues in both hippocampal gyri and lymphomatous cells in the liver, which could not be suspected on clinical examinations. Apparent malignant lymphoma cells were not found in lymph nodes. This case indicated peculiar evolution of malignant lymphoma from liver to CNS or vice versa. We could not decide which organ was primary. CT findings of this case was very interesting; they resembled ventriculitis, which simulate tumors such as medulloblastoma or ependymoma spreading under ependymal lining. (author)

  11. A call to expand regulation to all carcinogenic fibrous minerals

    Baumann, F.; Steele, I.; Ambrosi, J.; Carbone, M.

    2013-05-01

    The regulatory term "asbestos" groups only the six fibrous minerals that were commercially used among approximately 400. The carcinogenicity of these six regulated minerals has been largely demonstrated and is related to fiber structure, fiber length/diameter ratio, and bio-persistence. From a public perception, the generic term "asbestos" refers to the fibrous minerals that cause asbestosis, mesothelioma and other cancers. However, other non-regulated fibrous minerals are potentially as dangerous as the regulatory asbestos because they share similar physical and chemical properties, epidemiological studies have demonstrated their relationship with asbestos-related diseases, and both in vitro and in vivo experiments have established the toxicity of these minerals. For example, the non-regulated asbestiform winchite and richterite minerals that contaminated the vermiculite mined from Libby, Montana, (USA) were associated with mesothelioma, lung cancer and asbestosis observed among the area's residents and miners. Many other examples of non-regulated carcinogenic fibrous minerals include, but are not limited to, antigorite, arfvedsonite, balangeroite, carlosturanite, erionite, fluoro-edenite, hornblende, mordenite, palygorskite, and sepiolite. To propose a regulatory definition that would provide protection from all carcinogenic fibers, we have conducted an interdisciplinary literature review to compare the characteristics of "asbestos" and of non-regulated mineral fibers that relate to carcinogenicity. We specifically studied two non-regulated fibrous minerals that are associated with asbestos-related diseases: the serpentine antigorite and the zeolite erionite. Both examples underscore the problem of regulation based on commercial, rather than scientific principles: 1) the occurrence of fibrous antigorite in materials used to pave roads has been correlated with high mesothelioma rates in New Caledonia. Antigorite was also the cause of asbestosis in Poland, and in

  12. Rare case of a primary malignant fibrous histiozytoma of the brain

    An unusual case is described of MFH arising from the dura of the petrous bone, which we observed in a 45 year old patient. The findings of CCT before and after contrast injection and MRI are presented. (orig./MG)

  13. Tumor fibroso solitário maligno de extremidades Malignant solitary fibrous tumour of the extremities

    Daniel Chang; Cláudia Regina Gomes Cardim Mendes de Oliveira; Carlos Fernando Saito

    2010-01-01

    Tumor fibroso solitário extrapleural (TFS) é neoplasia mesenquimal rara, sendo que há menos de 40 casos descritos com localização em extremidades até o presente momento. Acomete preferencialmente pacientes na quinta década e não tem predileção por sexo. Relatamos um caso com os aspectos clínicos, radiológicos, histológicos e imunoistoquímicos característicos, discutindo a importância do diagnóstico diferencial com outros sarcomas.Pouco é conhecido sobre o comportamento biológico do TFS. Fator...

  14. Malignant teratoma (image)

    A malignant teratoma is a type of cancer consisting of cysts that contain one or more of the three primary embryonic germ layers: ectoderm, mesoderm, and endoderm. Because malignant teratomas have usually spread by the time of diagnosis, ...

  15. Computed tomographic features of fibrous dysplasia of maxillofacial region

    Sontakke, Subodh Arun; Karjodka, Freny R [Nair Hospital Dental College, Mumba (India); Umarji, Hemant R [Government Dental College and Hospital, Mumbai (India)

    2011-03-15

    This study was to find the computed tomographic features of fibrous dysplasia of the maxillofacial region. All eight cases included in the study reported either to Government Dental College and Hospital or Nair Hospital Dental College, Mumbai between 2003 and 2009. The patients were prescribed computed tomogram in addition to conventional radiographs of maxillofacial region which were studied for characteristic features of fibrous dysplasia. The diagnosis of fibrous dysplasia was confirmed by histopathological report. All cases showed the ill-defined margins of lesions except in the region where the lesions were extending to cortex of the involved bone. Internal structure of all cases showed ground glass appearance. Four cases of maxillary lesion showed the displacement of maxillary sinus maintaining the shape of maxillary sinus. Two cases showed complete obliteration of maxillary sinus. Displacement of inferior alveolar canal did not follow any typical pattern in any of the cases but was displaced in different directions. The craniofacial type of fibrous dysplasia is as common as fibrous dysplasia of jaw. The margins, extent, internal structure and effect on surrounding structure are well detected on computed tomographic images.

  16. Craniofacial fibrous dysplasia - A review of current management techniques

    Yadavalli Guruprasad

    2012-01-01

    Full Text Available Fibrous dysplasia is a pathologic condition of bone of unknown etiology with no apparent familial, hereditary or congenital basis. Lichtenstein first coined the term in 1938 and in 1942 he and Jaffe separated it from other fibro-osseous lesions. It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton. Its management poses significant challenges to the surgeon. Craniofacial fibrous dysplasia is 1 of 3 types of fibrous dysplasia that can affect the bones of the craniofacial complex, including the mandible and maxilla. Fibrous dysplasia is a skeletal developmental disorder of the bone-forming mesenchyme that manifests as a defect in osteoblastic differentiation and maturation. It is a lesion of unknown etiology, uncertain pathogenesis, and diverse histopathology. Fibrous dysplasia represents about 2, 5% of all bone tumors and over 7% of all benign tumours. Over the years, we have gained a better understanding of its etiology, clinical behavior, and both surgical and non-surgical treatments.

  17. Recurring fibrous dysplasia of anthro maxillary with cranial base invasion

    Sousa, Kátia Maria Marabuco de

    2009-09-01

    Full Text Available Introduction: Fibrous dysplasia is an osseous lesion with an unknown etiology. It is characterized by the osseous maturation insufficiency. It may affect any bone, but the affection of craniofacial bones is the most critical for otorhinolaryngology. Maxilla is the most affected facial bone and the orbitary invasion is an uncommon event. The symptoms are unspecific and for its low suspicion and uncommonness, the diagnosis is generally late. The monostotic form presents a slow growth and asymptomatic course and needs to be followed up. The polyostotic type has a progressive behavior and is associated to recurrence and complications. Objective: To present two cases of patients with fibrous dysplasia diagnosis and describe the clinical presentation, radiological findings and the treatment of this pathology. Cases Report: Two cases of fibrous dysplasia are reported, which initially presented unspecific symptomatology, but with characteristic radiologic signs. They were submitted to surgical treatment for resection of the lesions and evolved with frequent recurrences with extensive affection of the facial sinuses, one patient had cranial base invasion and frontal craniotomy was needed for tumoral excision. Final Comments: Fibrous dysplasia is an uncommon osteopathy. The tomography is the choice method for characterization of the tumoral expansion, and helps in the surgical planning. The surgical strategy is indicated for symptomatic lesions, functions alterations or anatomic disorders. This article describes two uncommon manifestations of recurrent fibrous dysplasia with an extensive affection of anthro maxillary, ethmoidal and sphenoid sinuses, in addition to orbitary and cranial base invasion.

  18. Imaging findings of solitary fibrous tumors

    Objective: To investigate the imaging characteristics of solitary fibrous tumor (SFT). Methods: This study included 11 cases with SFT proved by pathological results. The imaging manifestations were retrospectively reviewed and analyzed in comparison with surgical and pathological results. Among them, 8 patients underwent CT plain scan (1/8) or enhanced scan (7/8), 4 patients underwent MR plain scan (2/4) or enhanced scan (2/4), and only 1 patient underwent both CT and MR scan. Results: (1) SFT were located in the thoracic cavity(2/11), abdominal and pelvis (5/11), and somatic soft tissues (4/11). The average tumor size was 11.8 cm (2.5 to 23.0 cm). Among them, 4 tumors were round or ellipse, and 7 tumors were irregular. Eight tumors had well-defined contours,and the others showed ill-defined contours. (2) On CT scan, all SFTs showed inhomogeneous density with low density areas. Calcification was seen in I case,and hemorrhagic foci were detected in 2 cases. (3) On MR scan, all SFTs showed intermediate signal intensity on T1WI. Three tumors were slightly hyperintense and the other was hypointense on T2WI. All of them were rich of vascular signal voids. Three tumors,including 2 tumors with scattered long T1 and T2 signal and 1 tumor in the liver with hyperintense haemorrhage, displayed inhomogeneous mixed signal.One tumor in the orbit showed homogeneous signal. (4) On enhanced scan, 9 tumors showed irregular enhancement with multiple circuitous vessels in the arterial phase, and continuous or progressive enhancement with patch non-enhanced areas in the venous phase. (5) Histologically, SFTs were composed of juxtaposed hyper- and hypo-cellular spindle cells, dense collagenous stroma and numerous thin-walled blood vessels with a staghorn configuration. Conclusion: The possibility of SFT should be considered when a single soft tissue mass with sharp border, inhomogeneous density is detected, especially with inhomogeneous enhancement maintaining in the venous phase

  19. Segmental neurofibromatosis and malignancy.

    Dang, Julie D; Cohen, Philip R

    2010-01-01

    Segmental neurofibromatosis is an uncommon variant of neurofibromatosis type I characterized by neurofibromas and/or café-au-lait macules localized to one sector of the body. Although patients with neurofibromatosis type I have an associated increased risk of certain malignancies, malignancy has only occasionally been reported in patients with segmental neurofibromatosis. The published reports of patients with segmental neurofibromatosis who developed malignancy were reviewed and the characteristics of these patients and their cancers were summarized. Ten individuals (6 women and 4 men) with segmental neurofibromatosis and malignancy have been reported. The malignancies include malignant peripheral nerve sheath tumor (3), malignant melanoma (2), breast cancer (1), colon cancer (1), gastric cancer (1), lung cancer (1), and Hodgkin lymphoma (1). The most common malignancies in patients with segmental neurofibromatosis are derived from neural crest cells: malignant peripheral nerve sheath tumor and malignant melanoma. The incidence of malignancy in patients with segmental neurofibromatosis may approach that of patients with neurofibromatosis type I. PMID:21137621

  20. Fibrous minerals from Somma-Vesuvius volcanic complex

    Rossi, Manuela; Nestola, Fabrizio; Ghiara, Maria R.; Capitelli, Francesco

    2016-08-01

    A survey on fibrous minerals coming from the densely populated area of Campania around the Somma-Vesuvius volcanic complex (Italy) was performed by means of a multi-methodological approach, based on morphological analyses, EMPA/WDS and SEM/EDS applications, and unit-cell determination through X-ray diffraction data. Such mineralogical investigation aims to provide suitable tools to the identification of fibrous natural phases, to improve the knowledge of both geochemical, petrogenetic and regional mineralogy of Somma-Vesuvius area, and to emphasize the presence of minerals with fibrous habit in all volcanic environments. The survey also fits well in the calls of health and environment of Horizon 2020 program of the European Commission (Climate Action, Environment, Resource Efficiency and Raw Materials).

  1. Polyostotic Fibrous Dysplasia of Cranio-Maxillofacial Area

    Fibrous dysplasia is believed to be a hamartomatous developmental lesion of unknown origin. This disease is divided into monostotic and polyostotic fibrous dysplasia. Polyostotic type can be divided into craniofacial type, Lichtenstein-Jaffe type, and McCune-Albright syndrome. In this case, a 31-year-old female presented spontaneous loss of right mandibular teeth before 5 years and has shown continuous expansion of right mandibular alveolus. Through the radiographic view, the coarse pattern of the mixed radiopaque-lucent lesion was seen on the right mandibular body, and there was diffuse pattern of the mixed radiopaque-lucent lesion with ill-defined margin in the left mandibular body. In the right calvarium, the lesion had cotton-wool appearance. Partial excision for contouring, multiple extraction, and alveoloplasty were accomplished under general anesthesia for supportive treatment. Finally we could conclude this case was polyostotic fibrous dysplasia of cranio-maxillofacial area based on the clinical, radiologic finding, and histopathologic examination.

  2. Polyostotic Fibrous Dysplasia of Cranio-Maxillofacial Area

    Han, Jin Woo; Kwon, Hyuk Rok; Lee, Jin Ho; Park, In Woo [Dept. of Oral and Maxillofacial Radiology, College of Dentistry, Kangnung National University, Kangnung (Korea, Republic of)

    2000-06-15

    Fibrous dysplasia is believed to be a hamartomatous developmental lesion of unknown origin. This disease is divided into monostotic and polyostotic fibrous dysplasia. Polyostotic type can be divided into craniofacial type, Lichtenstein-Jaffe type, and McCune-Albright syndrome. In this case, a 31-year-old female presented spontaneous loss of right mandibular teeth before 5 years and has shown continuous expansion of right mandibular alveolus. Through the radiographic view, the coarse pattern of the mixed radiopaque-lucent lesion was seen on the right mandibular body, and there was diffuse pattern of the mixed radiopaque-lucent lesion with ill-defined margin in the left mandibular body. In the right calvarium, the lesion had cotton-wool appearance. Partial excision for contouring, multiple extraction, and alveoloplasty were accomplished under general anesthesia for supportive treatment. Finally we could conclude this case was polyostotic fibrous dysplasia of cranio-maxillofacial area based on the clinical, radiologic finding, and histopathologic examination.

  3. Structural characteristics, dispersion, and modification of fibrous brucite

    Cao, Xi; Chuan, Xiu-yun

    2014-01-01

    Fibrous brucite has very unique structure and physical properties. Brucite fibers were exfoliated into single nanofibers by using dioctyl sodium sulfosuccinate (AOT) as a dispersant through mechanical agitation and ultrasonic dispersion; and then, the nanofibers were modified by stearic acid and (3-aminopropyl)triethoxysilane (γ-APS) compound modification agent. The nanofibers were characterized by using X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermal gravimetric analysis. It is found that AOT has good effect on the dispersion. The single fiber has a consistent morphology, and fibrous brucite is dispersed and modified without destroying the crystal structure. Infrared and thermal analysis shows that the surface modification of fibrous brucite is achieved by forming chemical bonds between the coupling agent and magnesium hydroxide.

  4. The behaviour of fibrous composite materials under nuclear radiations exposure

    The main feature of fibrous composite materials are briefly described, which are constitued by a netwoek of ceramic high performance fiber embebed in a ductile matrix material. These composite materials show such a kind of anisotropic strength that their uses has been widely spreaded in the last times. This philosophy of strengthening was used by the Nature, where are abundant examples of fibrous composites like horn, bamboo tissues, etc. In this paper are collected the published results about behaviour of reinforced dibers and fibrous composites under nuclear radiation exposure. The results show a very wide sort of fenomenae depending on many factors. Are fibers, like the boron one, which shows an inconvenient behaviour and another like graphite fibers which appears to improve its features. Is is concluded that was not achieved enough information about the behaviour of the interface under irradiation in order to build up a theory about the behaviour of the full composite under irradiation exposure. (author)

  5. Efficacy of trabectedin in metastatic solitary fibrous tumor

    Xavier Pivot

    2011-07-01

    Full Text Available Solitary fibrous tumor is a rare tumor type and has an unpredictable course. Local recurrence rate varies between 9 and 19 %, and rate of metastatic involvement between 0 and 36 %. It is characterized by a typical architecture and immuno-histochemistry tests. The most important prognostic factor is the complete resection of primary tumor. Treatment of recurrences is not clearly established. If a solitary fibrous tumor is too advanced to allow surgical resection, radiotherapy and chemotherapy may be used. The most often used drugs are doxorubicine andor ifosfamide. We report the case of man with metastatic solitary fibrous tumor treated with trabectedin, administered at a dose of 1.5 mg/m² every 3 weeks. After 3 cycles, metastases had significantly decreased. Recurrence of the disease was demonstrated 8 months after the start of trabectedin. This case shows that trabectedin is a possible treatment option.

  6. Fibrous dysplasia of the jaws associated with secondary hyperparathyroidism: a case report

    Whi, Jung Hyun; Kim, Young Joo; Chun, Kyung Ah; Kim, Ki Tae; Chang, Eun Deok; Kim, Young Ok; Lee, Won [The Catholic University of Korea, Uijongbu (Korea, Republic of)

    2007-06-15

    There have been few reports on fibrous dyplasia associated with secondary hyperparathyroidism. We report a case of a hemodialysis patient with secondary hyperparathyroidism concomitant with fibrous dysplasia of the jaws causing an abnormal deformity.

  7. Dedifferentiated Liposarcoma in the Retroperitoneum in an Atomic Bomb Survivor: Report of a Case

    Nakamura, Yukio; Yumiba, Takeyoshi; Yamasaki, Yoshio; Momiyama, Takuya; Ito, Akira; Akamaru, Yusuke; Kasugai, Tsutomu

    2008-01-01

    A 76-year-old Japanese man was admitted to Kosei-Nenkin Hospital (Osaka, Japan) in November 2006; his chief complaint was a 10-kg loss in body weight over 3 months prior to admission. Abdominal computed tomography (CT) and dynamic magnetic resonance imaging (MRI) showed three masses in the retroperitoneum. The patient subsequently underwent surgery. The final histopathological diagnosis of tumors 1 and 2 was malignant fibrous histiocytoma of the retroperitoneum, and tumor 3 was a well-differe...

  8. Immunohistochemical expression of promyelocytic leukemia body in soft tissue sarcomas

    Yasunaga Yuji; Ishikawa Masataka; Kubo Tadahiko; Shimose Shoji; Sugita Takashi; Matsuo Toshihiro; Ochi Mitsuo

    2008-01-01

    Abstract Background The function of promyelocytic leukemia (PML) bodies is not well known but plays an important role in controlling cell proliferation, apoptosis and senescence. This study was undertaken to analyze the clinical significance of PML body expression in primary tumor samples from malignant fibrous histiocytoma (MFH) and liposarcoma patients. Methods We studied MFH and liposarcoma samples from 55 patients for PML bodies. Fluorescent immunostaining of PML bodies was performed in t...

  9. Malignant colorectal polyps

    Luis; Bujanda; Angel; Cosme; Ines; Gil; Juan; I; Arenas-Mirave

    2010-01-01

    Nowadays, the number of cases in which malignant colorectal polyps are removed is increasing due to colorectal cancer screening programmes. Cancerous polyps are classified into non-invasive high grade neoplasia (NHGN), when the cancer has not reached the muscularis mucosa, and malignant polyps, classed as T1, when they have invaded the submucosa. NHGN is considered cured with polypectomy, while the prognosis for malignant polyps depends on various morphological and histological factors. The prognostic facto...

  10. Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma

    2014-09-08

    Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Childhood Alveolar Soft-part Sarcoma; Childhood Angiosarcoma; Childhood Epithelioid Sarcoma; Childhood Fibrosarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Mesenchymoma; Childhood Neurofibrosarcoma; Childhood Synovial Sarcoma; Dermatofibrosarcoma Protuberans; Metastatic Childhood Soft Tissue Sarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Stage I Adult Soft Tissue Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

  11. Fibrous random materials: From microstructure to macroscopic properties

    Yazdchi, K.; Luding, S.; A. Yu, R. Yang K. Dong

    2013-01-01

    Fibrous porous materials are involved in a wide range of applications including composite materials, fuel cells, heat exchangers and (biological)filters. Fluid flow through these materials plays an important role in many engineering applications and processes, such as textiles and paper manufacturin

  12. Extrinsic colonic obstruction by congenital fibrous band in an infant

    Catania, Vincenzo Davide; Olivieri, Claudio; Nanni, Lorenzo; Pintus, Claudio

    2013-01-01

    The finding of a congenital fibrous band during laparotomy for intestinal obstruction is extremely rare. Preoperative diagnosis is challenging and no characteristic radiological findings have been described. We report the case of a premature baby in whom incomplete intestinal obstruction was due to a congenital band originating from the duodeno-jejunal flexure and extending across the ascending colon.

  13. Compressibility of CNT-Grafted Fibrous Reinforcements: A Theory

    Lomov, S.V.; Koissin, V.; Karahan, M.; Godara, A.; Gorbatikh, L.; Verpoest, I.

    2010-01-01

    The paper introduces a theoretical model of compressibility of a nanotube forest with randomly oriented nanotubes, which is applied to predict compressibility of a fibrous reinforcement with CNT-grafted fibres. It is shown that the pressure needed to achieve the target fibre volume fraction of the p

  14. Localized fibrous mesothelioma of pleura following external ionizing radiation therapy

    Bilbey, J.H.; Mueller, N.L.M.; Miller, R.R.; Nelems, B.

    1988-12-01

    Carcinogenesis is a well-known complication of radiation exposure. Ionizing radiation also leads to an increased incidence of benign tumors. A 36-year-old woman had a localized fibrous mesothelioma of the pleura and an ipsilateral breast carcinoma 23 years after receiving external radiation therapy for treatment of a chest wall keloid.

  15. Deposition of fibrous nanostructure by ultrafast laser ablation

    This research work demonstrated that laser-induced reverse transfer (LIRT) can be used for controllable site-specific deposition of fibrous nanostructure. The LIRT method makes it possible to generate and deposit the fibrous nanostructure of a wide variety of materials on a transparent acceptor in a single-step process at an ambient condition. The deposition of fibrous nanostructures was conducted using ultrafast laser ablation of silicon and aluminum targets placed behind a glass acceptor. Femtosecond laser pulses pass through the transparent acceptor and hit the bulk donor. Consequently a mass quantity of nanoparticles ablates from the donor and then aggregates and forms a porous fibrous nanostructure on the transparent acceptor. Our experiments demonstrated that the gap between the target and the glass acceptor was critical in the formation and accumulation of nanofibers and it determines the density of the formed nanostructure. The formation mechanism of the nanostructures can be explained by the well-established theory of vapor condensation within the plume induced by ultrafast laser ablation. Experimental results also show that the length of the nanostructure can be controlled by the gap between the target and glass acceptor. Lastly, energy-dispersive x-ray spectroscopy (EDS) analysis shows the oxygen concentration in the nanofibrous structure which is associated with oxidation of ablated material at ambient atmosphere.

  16. Thermal protection studies of plastic films and fibrous materials

    Saad, Michel A.; Altman, Robert L.

    1988-01-01

    The thermal protection properties of various film and woven materials were studied using an experimental method of radiant heating. The materials studied included aluminized and unaluminized synthetic plastic films and fibrous materials like silicon carbide and phenolic novolac. It is shown that a thin metallized coating with good reflectivity significantly enhances the heat blocking capability of a variety of insulative materials.

  17. Solitary Fibrous Tumour of the Pleura – Cases Analysis

    Isolated fibrous tumor of the pleura (SFTP – Solitary fibrous tumour of the pleura/localized fibrous tumour of the pleura) is a rare primary tumour of the pleura of mesenchymal origin. In most cases, it is a benign lesion. It is composed of spindle cells similar to fibroblasts and derives probably from submesothelial mesenchyme. The aim of the study was to analyze clinical symptoms, incidence, possibility of suggesting the diagnosis on the basis of imaging tests, and confirmation of the diagnosis in pathological tests with regard to studies of histochemistry examination. Clinical and morphological material obtained from 14 patients from Department of Thoracic Surgery of Subcarpathian Chest Disease Center treated between year 2004 and 2010 was analysed. In the first stage, selected cases of patients with isolated fibrous tumour of the pleura were chosen from the archives and the analysis of their medical history was carried out. Basic information about age, gender, medical history, smoking habit, physical examination and results of imaging, endoscopic and morphological examinations were noted. The second parallel component of the study was pathomorphological examinations of the surgical material obtained from the patients, including the assessment of morphology and immunohistochemistry. Of the 14 examined patients, fibrous tumour occurred in 8 men and 6 women. The age range of the patients was 37–73 years, with a peak attributable to the 6th decade of life. In 8 patients the tumour was detected incidentally during routine examinations. In 7 patients there were no clinical signs of respiratory disease, and if present, then the most common complaint was shortness of breath. Regarding symptoms not connected with the respiratory system, anemia occurred most frequently. Fibrous tumour of the pleura was more often associated with the visceral pleura than with the parietal pleura. The largest lesion was approximately 20 cm in size. Fibrous tumour of the pleura is a

  18. Direct Numerical Simulation of Liquid Transport Through Fibrous Porous Media

    Palakurthi, Nikhil Kumar

    Fluid flow through fibrous media occurs in many industrial processes, including, but not limited, to fuel cell technology, drug delivery patches, sanitary products, textile reinforcement, filtration, heat exchangers, and performance fabrics. Understanding the physical processes involved in fluid flow through fibrous media is essential for their characterization as well as for the optimization and development of new products. Macroscopic porous-media equations require constitutive relations, which account for the physical processes occurring at the micro-scale, to predict liquid transport at the macro-scale. In this study, micro-scale simulations were conducted using conventional computational fluid dynamics (CFD) technique (finite-volume method) to determine the macroscopic constitutive relations. The first part of this thesis deals with the single-phase flow in fibrous media, following which multi-phase flow through fibrous media was studied. Darcy permeability is an important parameter that characterizes creeping flow through a fibrous porous medium. It has a complex dependence on the medium's properties such as fibers' in-plane and through-plane orientation, diameter, aspect ratio, curvature, and porosity. A suite of 3D virtual fibrous structures with a wide range of geometric properties were constructed, and the permeability values of the structures were calculated by solving the 3D incompressible Navier-Stokes equations. The through-plane permeability was found to be a function of only the fiber diameter, the fibers' through-plane orientation, and the porosity of the medium. The numerical results were used to extend a permeability-porosity relation, developed in literature for 3D isotropic fibrous media, to a wide range of fibers' through-plane orientations. In applications where rate of capillary penetration is important, characterization of porous media usually involves determination of either the effective pore radius from capillary penetration experiments

  19. Primary ovarian malignant melanoma

    Kostov Miloš

    2010-01-01

    Full Text Available Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

  20. Fibrous Ankylosis of the Temporomandibular Joint in a Young Child.

    Figueiredo, Nigel R; Meena, Manoj; Dinkar, Ajit D; Khorate, Manisha M

    2015-01-01

    Temporomandibular joint (TMJ) ankylosis is an intracapsular union of the disccondyle complex to the temporal articular surface that restricts mandibular movements, including fibrous adhesions or bony fusion between the condyle, disc, glenoid fossa, and articular eminence. The leading causes include trauma and infection. It can be a serious and disabling condition that leads to difficulties in mastication, swallowing, speaking, esthetics and oral hygiene. Disturbances of facial and mandibular growth and acute compromise of the airway invariably result in physical and psychological disability. Treatment should be initiated as soon as the condition is recognized, with the main objective of re-establishing joint function and harmonious jaw function. The purpose of this report is to describe a case of unilateral fibrous ankylosis of the right TMJ in a three-year-old girl. PMID:26349799

  1. Fibrous random materials: From microstructure to macroscopic properties

    Yazdchi, K.; Luding, S.

    2013-06-01

    Fibrous porous materials are involved in a wide range of applications including composite materials, fuel cells, heat exchangers and (biological)filters. Fluid flow through these materials plays an important role in many engineering applications and processes, such as textiles and paper manufacturing or transport of (under)ground water and pollutants. While most porous materials have complex geometry, some can be seen as two-dimensional particulate/fibrous systems, in which we introduce several microscopic quantities, based on Voronoi and Delaunay tessellations, to characterize their microstructure. In particular, by analyzing the topological properties of Voronoi polygons, we observe a smooth transition from disorder to order, for increasing packing fraction. Using fully resolved finite element (FE) simulations of Newtonian, incompressible fluid flow perpendicular to the fibres, the macroscopic permeability is calculated in creeping flow regimes. The effect of fibre arrangement and local crystalline regions on the macroscopic permeability is discussed and the macroscopic property is linked to the microscopic structural quantities.

  2. Electrospun Fibrous Membranes with Super-large-strain Electric Superhydrophobicity

    Zhou, Hua; Wang, Hongxia; Niu, Haitao; Lin, Tong

    2015-10-01

    Large-strain elastic superhydrophobicity is highly desirable for its enhanced use performance and functional reliability in mechanically dynamic environments, but remains challenging to develop. Here we have, for the first time, proven that an elastic fibrous membrane after surface hydrophobization can maintain superhydrophobicity during one-directional (uniaxial) stretching to a strain as high as 1500% and two-direction (biaxial) stretching to a strain up to 700%. The fibrous membrane can withstand at least 1,000 cycles of repeated stretching without losing the superhydrophobicity. Stretching slightly increases the membrane air permeability and reduces water breakthrough pressure. It is highly stable in acid and base environments. Such a permeable, highly-elastic superhydrophobic membrane may open up novel applications in membrane separation, healthcare, functional textile and energy fields.

  3. An endochronic theory for transversely isotropic fibrous composites

    Pindera, M. J.; Herakovich, C. T.

    1981-01-01

    A rational methodology of modelling both nonlinear and elastic dissipative response of transversely isotropic fibrous composites is developed and illustrated with the aid of the observed response of graphite-polyimide off-axis coupons. The methodology is based on the internal variable formalism employed within the text of classical irreversible thermodynamics and entails extension of Valanis' endochronic theory to transversely isotropic media. Applicability of the theory to prediction of various response characteristics of fibrous composites is illustrated by accurately modelling such often observed phenomena as: stiffening reversible behavior along fiber direction; dissipative response in shear and transverse tension characterized by power-laws with different hardening exponents; permanent strain accumulation; nonlinear unloading and reloading; and stress-interaction effects.

  4. Development of flame resistant treatment for Nomex fibrous structures

    Toy, M. S.

    1977-01-01

    Flame resistant fibrous materials for space shuttle application were developed through chemical modification of commercially available aromatic polyamide fibrous products. The new surface treatment was achieved in the laboratory by ultraviolet activation of the fabric in the presence of fluoroolefin monomers and a diluent gas. The monomers grafted under these conditions provide the improved properties of the fabric in flame resistance, chemical inertness, and nonwettability without the sacrifice of color or physical properties. The laboratory reaction vessel was scaled-up to a batch continuous process, which treats ten yards of the commercial width textiles. The treated commercial width Nomex (HT-10-41) from the scaled-up reactor is self-extinguishing in an oxygen-enriched environment, water-repellent, soft, silky, and improved in chemical resistance. Unlike most textile processes, the grafting unit operates under dry conditions and no chemical by-products have to be washed out of the finished product.

  5. The aerosol penetration through an electret fibrous filter

    Jiang Wei; Cheung Chun-Shun; Chan Cheong-Ki; Zhu Chao

    2006-01-01

    The aim of this paper is to present a theoretical study of the aerosol penetration through an electret fibrous filter, using a numerical approach. The aerosol sizes considered in this study were in the submicron range, and in the numerical model, the conventional mechanical mechanisms (impaction, interception, diffusion and gravitationally settling) were taken into consideration along with the electrostatic mechanisms, including the Coulombic and dielectrophoretic effects. The aerosol penetration through an electret fibrous filter is heavily dependent on the aerosol penetration of a single fibre. The aerosol penetration through a single electret fibre under various filtration conditions was calculated. The effects of aerosol diameter, aerosol and fibre charge state, face velocity, packing density and aerosol dielectric constant on the aerosol penetration were investigated.

  6. Structural basis of contraction in vitreal fibrous membranes.

    Grierson, I; Rahi, A H

    1981-01-01

    A combined ultrastructural and immunofluorescent study was conducted on experimentally induced fibrous membranes in the vitreous of adult rabbits. Autochthonous tissue cultured fibroblasts were injected into the mid-vitreous of one eye of each of 25 rabbits. The animals were monitored routinely with an ophthalmoscope and slit-lamp and were killed at various time periods between 5 minutes and 6 months. Appropriate tissue was taken for light microscopy, transmission electron microscopy, scannin...

  7. Configuration of Fibrous and Adipose Tissues in the Cavernous Sinus

    Liang, Liang; Gao, Fei; Xu, Qunyuan; Zhang, Ming

    2014-01-01

    Objective Three-dimensional anatomical appreciation of the matrix of the cavernous sinus is one of the crucial necessities for a better understanding of tissue patterning and various disorders in the sinus. The purpose of this study was to reveal configuration of fibrous and adipose components in the cavernous sinus and their relationship with the cranial nerves and vessels in the sinus and meningeal sinus wall. Materials and Methods Nineteen cadavers (8 females and 11 males; age range, 54–89...

  8. Carbon-Based Fibrous EDLC Capacitors and Supercapacitors

    Lekakou, C.; O. Moudam; Markoulidis, F; Andrews, T.; J. F. Watts; Reed, G.T.

    2011-01-01

    This paper investigates electrochemical double-layer capacitors (EDLCs) including two alternative types of carbon-based fibrous electrodes, a carbon fibre woven fabric (CWF) and a multiwall carbon nanotube (CNT) electrode, as well as hybrid CWF-CNT electrodes. Two types of separator membranes were also considered. An organic gel electrolyte PEO-LiCIO4-EC-THF was used to maintain a high working voltage. The capacitor cells were tested in cyclic voltammetry, charge-discharge, and impedance test...

  9. Radiologic Features of Fibrous Hamartoma of Infancy Involving the Buttocks

    Fibrous hamartoma of infancy (FHI) is a rare benign subcutaneous tumor that presents in children younger than two years. The tumor mostly affects the trunk, axilla and upper extremities. Imaging findings of FHI that involve the buttocks have not been reported in the clinical literature. We reported the imaging features of a lesion in a 9-month-old infant who presented with a palpable mass on the buttocks. The imaging findings were evaluated after a review of previous studies

  10. Surgical treatment of fibrous dysplasia in the proximal femur

    TONG, ZHICHAO; Zhang, Wentao; Jiao, Ning; Wang, Kunzheng; Chen, Bo; Yang, Tuanmin

    2013-01-01

    The aim of this study was to summarize oncological and functional results and to investigate surgical treatment methods and efficacies by conducting a retrospective study of patients with fibrous dysplasia (FD) in the proximal femur. A total of 15 patients with FD in the proximal femur were selected. Among them, 12 cases were monostotic and 3 cases were polyostotic. In addition, 2 cases were accompanied by shepherd’s crook deformity. All cases received internal fixation following focus curett...

  11. Fibrous Calcareous Concretions in the Capsules of Human Pineal Glands

    Kodaka Tetsuo; Mori Ryoichi; Ezure Hiromitsu; Ito Junji; Otsuka Naruhito

    2013-01-01

    We examined calcareous concretions in the capsule of 15 human pineal glands containing a large amount of the concretions in the matrix. The capsule concretions, brown to blackish-brown in color and/or translucent, were smaller than the matrix concretions, which were yellowish-white. The matrix concretions showed the typical mulberry-shaped overall appearance with scallop-shaped concentric laminations of non-fibrous structures, but the capsule concretions, which also contained Ca and P, showed...

  12. Structural Damping by the Use of Fibrous Materials

    Kim, Nicholas N.; Lee, Seungkyu; Bolton, J Stuart; Hollands, Sean; Yoo, Taewook

    2015-01-01

    Because of the increasing concern with vehicle weight, there is an interest in lightweight materials that can serve several functions at once. Here we consider the vibration damping performance provided by an “acoustical” material (i.e., a fibrous layer that would normally be used for airborne noise control). It has been previously established that the vibration of panel structures creates a non-propagating nearfield in the region close to the panel. In that region, there is an oscillatory, i...

  13. Transition metal complexing with polymetric sulfur-containing fibrous ligand

    A study was made on interaction of Cr4, V5, Cu2 transition metals with thioamidated polymeric PVS-PAN-T ligand of fibrous structure. Sorption characteristics of PVS-PAN-T, depending on pH and temperature of solutions of copper, chromium and vanadium salts were determined. Parameters of ESR spectra of PVS-PAN-T compounds with transition metals enabled to determine the structure of formed coordination centers

  14. Elastic-plastic behavior of non-woven fibrous mats

    Silberstein, Meredith N.; Pai, Chia-Ling; Rutledge, Gregory C.; Boyce, Mary C.

    2012-02-01

    Electrospinning is a novel method for creating non-woven polymer mats that have high surface area and high porosity. These attributes make them ideal candidates for multifunctional composites. Understanding the mechanical properties as a function of fiber properties and mat microstructure can aid in designing these composites. Further, a constitutive model which captures the membrane stress-strain behavior as a function of fiber properties and the geometry of the fibrous network would be a powerful design tool. Here, mats electrospun from amorphous polyamide are used as a model system. The elastic-plastic behavior of single fibers are obtained in tensile tests. Uniaxial monotonic and cyclic tensile tests are conducted on non-woven mats. The mat exhibits elastic-plastic stress-strain behavior. The transverse strain behavior provides important complementary data, showing a negligible initial Poisson's ratio followed by a transverse:axial strain ratio greater than -1:1 after an axial strain of 0.02. A triangulated framework has been developed to emulate the fibrous network structure of the mat. The micromechanically based model incorporates the elastic-plastic behavior of single fibers into a macroscopic membrane model of the mat. This representative volume element based model is shown to capture the uniaxial elastic-plastic response of the mat under monotonic and cyclic loading. The initial modulus and yield stress of the mat are governed by the fiber properties, the network geometry, and the network density. The transverse strain behavior is linked to discrete deformation mechanisms of the fibrous mat structure including fiber alignment, fiber bending, and network consolidation. The model is further validated in comparison to experiments under different constrained axial loading conditions and found to capture the constraint effect on stiffness, yield, post-yield hardening, and post-yield transverse strain behavior. Due to the direct connection between

  15. Determination of physical properties of fibrous thermal insulation

    Jeandel G.; Monod B.; Lassue S.; Joulin A.; Tilioua A.; Libessart L.

    2012-01-01

    The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET) with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool) are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a de...

  16. Analysis of effective thermal conductivity of fibrous materials

    Futschik, Michael W.; Witte, Larry C.

    1993-01-01

    The objective of this research is to gain a better understanding of the various mechanisms of heat transfer through fibrous materials and to gain insight into how fill-gas pressure influences the effective thermal conductivity. By way of first principles and some empiricism, two mathematical models are constructed to correlate experimental data. The data are obtained from a test series measuring the effective thermal conductivity of Nomex using a two-sided guarded hot-plate heater apparatus. Tests are conducted for certain mean temperatures and fill-gases over a range of pressures varying from vacuum to atmospheric conditions. The models are then evaluated to determine their effectiveness in representing the effective thermal conductivity of a fibrous material. The models presented herein predict the effective thermal conductivity of Nomex extremely well. Since the influence of gas conduction is determined to be the most influential component in predicting the effective thermal conductivity of a fibrous material, an improved representation of gas conduction is developed. Finally, some recommendations for extension to other random-oriented fiber materials are made concerning the usefulness of each model depending on their advantages and disadvantages.

  17. Feed Technology of Fibrous Sugarcane Residues for Ruminants

    Kuswandi

    2007-06-01

    Full Text Available Abundant sugarcane residue during shortage of roughage in dry season gives an opportunity to raise ruminants around sugarcane industries. However, these products are not widely used by farmers due to an assumption that the usage is inefficient and that the feed utilization technology is not widely recognized. Sugarcane fibrous residues (tops, bagasse and pith may be a potential feed component if pre-treated to increase its digestion and consumption by the animal, and/or supplemented by other ingredients to balance nutrients in the rumen as well as those for production purpose. Digestibility can be increased by chemical treatments such as ammoniation and other alkaline treatments, whereas consumption can be increased by physical treatments such as grinding, hammermilling or pelleting. Nutrients that are missing in these fibrous residues can be provided by addition of urea, molasses and minerals for maintenance need, and bypass nutrients (carbohydrates, protein and fats that are digested in the small intestine and available for tissue or milk synthesis. There are three options for development of livestock agribusiness based on fibrous sugarcane residues; however, these require several technologies to optimize the utilization of these residues.

  18. The Current Status of Solitary Fibrous Tumor: Diagnostic Features, Variants, and Genetics.

    Thway, Khin; Ng, Wen; Noujaim, Jonathan; Jones, Robin L; Fisher, Cyril

    2016-06-01

    Solitary fibrous tumor (SFT) is a fibroblastic mesenchymal tumor originally described in the pleura but now shown at almost every anatomic site. Histopathologically, SFT is characteristically a circumscribed neoplasm composed of variably cellular and patternless distributions of bland spindle and ovoid cells within prominent collagenous stroma and shows diffuse expression of CD34, but it has a broad spectrum of both morphology and of biologic behavior. Many different names (particularly hemangiopericytoma) were previously used in the course of our understanding of this neoplasm but are now subsumed under the term "SFT," and the putative cell of origin was debated. However, it is now recognized that SFT is a translocation-associated neoplasm, consistently associated with NAB2-STAT6 gene fusions arising from recurrent intrachromosomal rearrangements on chromosome 12q, and this translocation is a likely major contributor to its pathogenesis. While most SFT with classical morphologic features behave in an indolent manner and those with overtly malignant histologic features tend to be aggressive neoplasms that behave as high-grade sarcomas, the behavior of SFT is unpredictable, and it is important to be aware of the propensity for aggressive behavior in a minority of histologically classical SFT and to ensure adequate clinical follow-up. Surgical excision remains the treatment gold standard; while radiotherapy and conventional chemotherapeutic agents have only shown limited efficacy, further understanding of the molecular events underlying tumorigenesis may allow the development of novel targeted treatments. We review SFT, discussing the morphologic spectrum and variants, including malignant and dedifferentiated subtypes, clinicopathological aspects, recent molecular genetic findings, and the differential diagnosis. PMID:26811389

  19. Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues

    Steinau Hans-Ulrich

    2006-07-01

    Full Text Available Abstract Background Solitary fibrous tumors (SFT represent a rare entity of soft tissue tumors. Previously considered being of serosal origin and solely limited to the pleural cavity the tumor has been described in other locations, most particularly the head and neck. Extrathoracic SFT in the soft tissues of the trunk and the extremities are very rare. Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and treatment results. Methods Data were obtained from patients' records, phone calls to the patients' general practitioners, and clinical follow-up examination, including chest X-ray, abdominal ultrasound, and MRI or computed tomography. Results There were 6 females and 3 males, whose age at time of diagnosis ranged from 32 to 92 years (mean: 62.2 years. The documented tumors' size was 4.5 to 10 cm (mean: 7 cm. All tumors were located in deep soft tissues, 3 of them epifascial, 2 subfascial, 4 intramuscular. Four tumors were found at the extremities, one each at the flank, in the neck, at the shoulder, in the gluteal region, and in the deep groin. Two out of 9 cases were diagnosed as atypical or malignant variant of ESFT. Complete resection was performed in all cases. Follow-up time ranged from 1 to 71 months. One of the above.mentioned patients with atypical ESFT suffered from local relapse and metastatic disease; the remaining 8 patients were free of disease. Conclusion ESFT usually behave as benign soft tissue tumors, although malignant variants with more aggressive local behaviour (local relapse and metastasis may occur. The risk of local recurrence and metastasis correlates to tumor size and histological status of surgical resection margins and may reach up to 10% even in so-called "benign" tumors. Tumor specimens should be evaluated by experienced soft tissue pathologists. The treatment of choice is complete resection followed by extended follow

  20. Stages of Malignant Mesothelioma

    ... chest cavity and covers the lungs ) or the peritoneum (the thin layer of tissue that lines the ... to diagnose malignant mesothelioma in the chest or peritoneum: Physical exam and history : An exam of the ...

  1. Imaging malignant and apparent malignant transformation of benign gynaecological disease

    Lee, A.Y.; Poder, L.; Qayyum, A.; Wang, Z.J.; Yeh, B.M. [Department of Radiology, University of California San Francisco, San Francisco, CA (United States); Coakley, F.V., E-mail: Fergus.Coakley@radiology.ucsf.ed [Department of Radiology, University of California San Francisco, San Francisco, CA (United States)

    2010-12-15

    Common benign gynaecological diseases, such as leiomyoma, adenomyosis, endometriosis, and mature teratoma, rarely undergo malignant transformation. Benign transformations that may mimic malignancy include benign metastasizing leiomyoma, massive ovarian oedema, decidualization of endometrioma, and rupture of mature teratoma. The aim of this review is to provide a contemporary overview of imaging findings in malignant and apparent malignant transformation of benign gynaecological disease.

  2. Imaging malignant and apparent malignant transformation of benign gynaecological disease

    Common benign gynaecological diseases, such as leiomyoma, adenomyosis, endometriosis, and mature teratoma, rarely undergo malignant transformation. Benign transformations that may mimic malignancy include benign metastasizing leiomyoma, massive ovarian oedema, decidualization of endometrioma, and rupture of mature teratoma. The aim of this review is to provide a contemporary overview of imaging findings in malignant and apparent malignant transformation of benign gynaecological disease.

  3. The Malignant Protein Puzzle.

    Walker, Lary C; Jucker, Mathias

    2016-01-01

    When most people hear the words malignant and brain, cancer immediately comes to mind. But our authors argue that proteins can be malignant too, and can spread harmfully through the brain in neurodegenerative diseases that include Alzheimer's, Parkinson's, CTE, and ALS. Studying how proteins such as PrP, amyloid beta, tau, and others aggregate and spread, and kill brain cells, represents a crucial new frontier in neuroscience. PMID:27408676

  4. Solitary fibrous tumor of the pancreas: Case report and review of the literature.

    Paramythiotis, Daniel; Kofina, Konstantinia; Bangeas, Petros; Tsiompanou, Fani; Karayannopoulou, Georgia; Basdanis, George

    2016-06-27

    Solitary fibrous tumor (SFT) is a mesenchymal tumor typically located in the pleura, but can also be found as an asymptomatic mass in other areas, including the liver, peritoneum, kidney and salivary glands. However, SFT rarely locates in the pancreas. We present such a case of pancreatic SFT, along with a review of all reported cases. A 55-year-old man was treated surgically for an asymptomatic pancreatic mass after a rigorous preoperative control. Histologic examination of the resected specimen showed characteristics of an SFT. As only 15 cases of pancreatic SFT have been reported so far, an attempt to compare the cases was considered intriguing. We found that patients with pancreatic SFT were mainly women (81.25%), with a median age of 54 years at the time of diagnosis and a median tumor size of 5.83 cm. Pancreatic SFTs were revealed incidentally in 50% of cases, and all of them showed an enhancement through arterial computed tomography. All tumors were positive for CD34, ten were positive for Bcl-2, and twelve were negative for S100. The diagnosis of this pancreatic tumor is established by a combination of clinical suspicion, imaging procedures and histological findings, and is confirmed by immunohistochemical staining. Although the behavior of SFTs is rather benign, close clinical follow-up is recommended due to a potentially malignant nature. PMID:27358679

  5. Giant solitary fibrous tumor of the pleura causing respiratory insufficiency: report of 3 cases.

    Abe, Masaru; Nomori, Hiroaki; Fukazawa, Motoji; Sugimura, Hiroshi; Narita, Makoto; Takeshi, Akihiko

    2014-01-01

    We present 3 cases of solitary fibrous tumors (SFTs) occupying entire hemithorax and resulting in respiratory insufficiency. All patients were treated by complete resection, resulting in immediate re-expansion of the lungs and recovery from respiratory insufficiency. Although, two patients remain alive without recurrence, one patient had pleural recurrences three times over a 20-year period, all of which were treated by surgical resection. All of the primary tumors exhibited areas of hypercellularity, hemorrhage, or necrosis. All of the recurrent tumors in the recurrent case displayed large areas of hypercellularity, similar to the part of primary tumor. Although, the MIB-1 index in primary tumors was less than 5%, the index of the recurrent tumors increased up to 11% with repeated recurrence. Giant SFTs usually display hypercellularity, hemorrhage, or necrosis. Tumors with hypercellularity could recur. MIB-1 index could display malignant characteristics of recurrent tumors. Long-term follow-up for more than 10 years after surgery is necessary, particularly for tumors with areas of hypercellularity. PMID:24088920

  6. Sorafenib Tosylate in Treating Patients With Malignant Mesothelioma.

    2013-06-04

    Epithelial Mesothelioma; Recurrent Malignant Mesothelioma; Sarcomatous Mesothelioma; Stage IA Malignant Mesothelioma; Stage IB Malignant Mesothelioma; Stage II Malignant Mesothelioma; Stage III Malignant Mesothelioma; Stage IV Malignant Mesothelioma

  7. Fibrous dysplasia mimicking bone metastasis on both bone scintigraphy and 18F FDG PET CT: Diagnostic dilemma in a patient with breast cancer

    Bone is the most common distant site to which breast cancer metastasizes. Commonly used imaging modalities for imaging bone metastasis are bone scintigraphy, plain radiography, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Although bone scintigraphy gas high sensitivity for detecting bone metastasis, its specificity is low. This is because of the fact that bone scintigraphy images secondary changes in bone rather than just tumor cells 18F fluorodeoxyglucose (18F FDG) PET CT, on the other hand, directly images the tumor cells' glucose metabolism. Unfortunately, similar to bone scintigraphy, benign bone conditions can also show increased 18F FDG uptake on PET CT, and PET positive asymptomatic fibrous dysplasia can be misinterpreted as a metastasis. Fibrous dysplasia of bone has wide skeletal distribution, with variability of 18F FDG uptake and CT appearance. It is therefore important to recognize the characteristics of this skeletal dysplasia, to allow differentiation from skeletal metastasis. Bone lesions with 18F FDG uptake need to be carefully interpreted when evaluating patients with known malignancy. In doubtful cases, fibrous dysplasia should be given as a differential diagnosis and histopathological diagnosis may be warranted, as highlighted in the present case

  8. Fibrous dysplasia mimicking bone metastasis on both bone scintigraphy and {sup 18}F FDG PET CT: Diagnostic dilemma in a patient with breast cancer

    KC, Sud Hir Suman; Sharma, Punit; Singh, Har Man Deep; Bal, Chand Rasekhar; Kumar, Rake Sh [India Institute of Medical Sciences, New Delhi (India)

    2012-12-15

    Bone is the most common distant site to which breast cancer metastasizes. Commonly used imaging modalities for imaging bone metastasis are bone scintigraphy, plain radiography, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Although bone scintigraphy gas high sensitivity for detecting bone metastasis, its specificity is low. This is because of the fact that bone scintigraphy images secondary changes in bone rather than just tumor cells {sup 18}F fluorodeoxyglucose ({sup 18}F FDG) PET CT, on the other hand, directly images the tumor cells' glucose metabolism. Unfortunately, similar to bone scintigraphy, benign bone conditions can also show increased {sup 18}F FDG uptake on PET CT, and PET positive asymptomatic fibrous dysplasia can be misinterpreted as a metastasis. Fibrous dysplasia of bone has wide skeletal distribution, with variability of {sup 18}F FDG uptake and CT appearance. It is therefore important to recognize the characteristics of this skeletal dysplasia, to allow differentiation from skeletal metastasis. Bone lesions with {sup 18}F FDG uptake need to be carefully interpreted when evaluating patients with known malignancy. In doubtful cases, fibrous dysplasia should be given as a differential diagnosis and histopathological diagnosis may be warranted, as highlighted in the present case.

  9. Management of malignant pleural effusions.

    Uzbeck, Mateen H

    2010-06-01

    Malignant pleural effusions are a common clinical problem in patients with primary thoracic malignancy and metastatic malignancy to the thorax. Symptoms can be debilitating and can impair tolerance of anticancer therapy. This article presents a comprehensive review of pharmaceutical and nonpharmaceutical approaches to the management of malignant pleural effusion, and a novel algorithm for management based on patients\\' performance status.

  10. A constitutional de novo mutation in exon 8 of the p53 gene in a patient with multiple primary malignancies.

    Speiser, P.; Gharehbaghi-Schnell, E.; Eder, S.; Haid, A.; Kovarík, J.; Nenutil, R.; Sauter, G.; Schneeberger, C. H.; Vojtesek, B.; Wiltschke, C. H.; Zeillinger, R.

    1996-01-01

    We report a constitutional point mutation of codon 278 in exon 8 of the TP53 gene that has not yet been described as a germ-line mutation. A 52-year-old female developed multiple primary malignancies (liposarcoma, breast cancer, malignant histiocytoma, occult adenocarcinoma). The mutation found in her tumour and peripheral blood lymphocyte DNA is a cytosine to thymine transition at the second position of codon 278 resulting in an amino acid exchange from proline to leucine in the DNA-binding domain. Evaluation of the patient's family revealed that both of her sons were affected by the same mutation. Although the patient's mother had died already, we were able to demonstrate by polymorphic microsatellite analysis that the defective allele originated from the maternal side. As four brothers and one sister had inherited the same allele, which however was wild type, we were able to show that the mutation must have occurred in the germ cells of the patient's mother and that it may therefore be called de novo. This explains the lack of a high cancer incidence in the family history. All tumours tested showed positive immunohistochemical staining for p53. Loss of heterozygosity was found in five of seven tumours, one showing chromosome 17 monosomy. Images Figure 1 PMID:8688334

  11. Aggressive malignant abdominal mesothelioma: Clinical report

    A 32-year-old Filipino female, working as an x-ray technician, presented to the Emergency Room (ER) with acute abdominal pain for one day. The pain was mainly on the left side and left hypochondrium. She had recurring abdominal pain before but not significant to worry her. She also complained of abdominal distension, which she noticed one week ago. Abdominal examination revealed fullness in the left hypochondrium with marked tenderness but negative rebound. Abdominal ultrasound (US) showed a huge mass mainly in the left hypochondrium. The origin of the mass cannot be identified by US. A computerized tomography scan showed a mass in the left side of the abdomen crossing the midline with a necrotic centre. The hospital course of the patient runs smoothly, and she was discharged after 7-days and referred to an Oncology Center. Abdominal mesothelioma is a neoplasm arising from the mesothelial surface lining the abdominal cavity. It is less frequent than that of the pleura. It is a rapidly growing and fatal malignancy with a median survival of less than 1-year. The relation between pleural malignant mesothelioma and asbestos is well recognized since it was described in 19602 but implication of asbestos exposure in the etiology of the peritoneal type is less obvious. This patient history is giving no obvious exposure to asbestos but as she is working in the Radiology Department as an x-ray technician she is well exposed to x-ray, but the effect of radioactivity on induction of mesothelioma is still disputed.4 There are several reports linking malignant mesothelioma to radioactivity due to radiation therapy.The fibrous mesothelioma (sarcomatous), as in this case, which is difficult to diagnose microscopically, looks like a fibroma, unless helped by tissue culture. The treatment options of malignant mesothelioma include surgery, intraperitoneal chemotherapy and whole abdominal radiation or multimodality therapy, which were suggested that might prolong the survival in

  12. Microstructure and properties of nano-fibrous PCL-b-PLLA scaffolds for cartilage tissue engineering

    L. He; B. Liu; G Xipeng; Xie, G; S. Liao; D Quan; Cai, D.; Lu, J.; S. Ramakrishna

    2009-01-01

    Nano-fibrous scaffolds which could potentially mimic the architecture of extracellular matrix (ECM) have been considered a good candidate matrix for cell delivery in tissue engineering applications. In the present study, a semicrystalline diblock copolymer, poly(e-caprolactone)-block-poly(L-lactide) (PCL-b-PLLA), was synthesized and utilized to fabricate nano-fibrous scaffolds via a thermally induced phase separation process. Uniform nano-fibrous networks were created by quenching a PCL-b-PLL...

  13. Identification of Autotoxic Compounds in Fibrous Roots of Rehmannia (Rehmannia glutinosa Libosch.)

    Zhen-Fang Li; Yan-Qiu Yang; Dong-Feng Xie; Lan-Fang Zhu; Zi-Guan Zhang; Wen-Xiong Lin

    2012-01-01

    Rehmannia is a medicinal plant in China. Autotoxicity has been reported to be one of the major problems hindering the consecutive monoculture of Rehmannia. However, potential autotoxins produced by the fibrous roots are less known. In this study, the autotoxicity of these fibrous roots was investigated. Four groups of autotoxic compounds from the aqueous extracts of the fibrous roots were isolated and characterized. The ethyl acetate extracts of these water-soluble compounds were further anal...

  14. Urethral Solitary Fibrous Tumor: A Rare Pathologic Diagnosis of a Periurethral Mass

    Semerjian, Alice

    2016-01-01

    Solitary fibrous tumors (SFTs) may occur at any site in the body. SFTs can only be conclusively diagnosed based on histopathologic and immunohistochemical characteristics of the tumor. The presence of SFTs in the abdomen and pelvis is extremely rare. To our knowledge no cases of urethral solitary fibrous tumor in the literature have been reported so far. We present a case of a solitary fibrous tumor arising from the urethra in a twenty-three-year-old female presenting with vaginal mass.

  15. Lack of a Common or Characteristic Cytogenetic Anomaly in Solitary Fibrous Tumor

    Torabi, Alireza; Lele, Subodh M.; DiMaio, Dominick; Pinnt, Jeffrey C.; Hess, Michelle M.; Nelson, Marilu; Bridge, Julia A.

    2008-01-01

    Solitary fibrous tumor is a mesenchymal tumor that was initially described as a pleural-based lesion, but later was discovered in many other locations. The light microscopic appearance of solitary fibrous tumor may overlap with other diagnostic entities; however, consistent tumor cell CD34 immunoreactivity is useful in establishing the diagnosis. Limited data suggest that solitary fibrous tumors are karyotypically diverse; a common or characteristic anomaly has not yet emerged for this entity...

  16. Permeability and compression of fibrous porous media generated from dilute suspensions of fiberglass debris during a loss of coolant accident

    Highlights: • Experimental investigation on fibrous debris buildup was conducted. • Head loss through fibrous media was recorded at different approach velocities. • A head loss model through fibrous media was proposed for high porosity (>0.99). • A compression model of fibrous media was developed. - Abstract: Permeability of fibrous porous media has been studied for decades in various engineering applications, including liquid purifications, air filters, and textiles. In nuclear engineering, fiberglass has been found to be a hazard during a Loss-of-Coolant Accident. The high energy steam jet from a break impinges on surrounding fiberglass insulation materials, producing a large amount of fibrous debris. The fibrous debris is then transported through the reactor containment and reaches the sump strainers. Accumulation of such debris on the surface of the strainers produces a fibrous bed, which is a fibrous porous medium that can undermine reactor core cooling. The present study investigated the buildup of fibrous porous media on two types of perforated plate and the pressure drop through the fibrous porous media without chemical effect. The development of the fibrous bed was visually recorded in order to correlate the pressure drop, the approach velocity, and the thickness of the fibrous porous media. The experimental results were compared to semi-theoretical models and theoretical models proposed by other researchers. Additionally, a compression model was developed to predict the thickness and the local porosity of a fibrous bed as a function of pressure

  17. A fibrous band associated with the non-coronary aortic valve cusp in a dog.

    Ajithdoss, Dharani K; Arenas-Gamboa, Angela M; Edwards, John F

    2011-06-01

    A fibrous band connecting the middle of the free edge (nodulus Arantii) of the non-coronary aortic valve cusp to the ascending aorta just above the level of the non-coronary sinus of Valsalva was observed in an asymptomatic, 11-year-old, male Border Collie. The fibrous band was unrelated to the cause of the death in this dog. Such fibrous bands are usually reported in humans with congenital bicuspid aortic valves. To our knowledge, this is the first report of a fibrous band in the aortic valve in a domestic animal. PMID:21641896

  18. Malignant salivary gland tumours

    Thompson, S.H. (University of the Witwatersrand, Johannesburg (South Africa). Dept. of Oral Pathology)

    1982-08-01

    The most frequent malignant salivary gland tumours are the mucoepidermoid tumour, adenoid cystic carcinoma and adenocarcinoma. The major salivary glands and the minor glands of the mouth and upper respiratory tract may potentially develop any of these malignant lesions. Malignant lesions most frequently present as a palpable mass and tend to enlarge more rapidly than benign neoplasms. Pain, paresthesia, muscle paralysis and fixation to surrounding tissue are all ominous signs and symptoms. The only reliable means of differential diagnosis of these lesions is biopsy and histologic analysis. Therapy involves surgery or a combination of surgery and radiation therapy. The ultimate prognosis is governed by the intrinsic biologic behaviour of the neoplasms, the extent of disease and adequate clinical therapy.

  19. Malignant salivary gland tumours

    The most frequent malignant salivary gland tumours are the mucoepidermoid tumour, adenoid cystic carcinoma and adenocarcinoma. The major salivary glands and the minor glands of the mouth and upper respiratory tract may potentially develop any of these malignant lesions. Malignant lesions most frequently present as a palpable mass and tend to enlarge more rapidly than benign neoplasms. Pain, paresthesia, muscle paralysis and fixation to surrounding tissue are all ominous signs and symptoms. The only reliable means of differential diagnosis of these lesions is biopsy and histologic analysis. Therapy involves surgery or a combination of surgery and radiation therapy. The ultimate prognosis is governed by the intrinsic biologic behaviour of the neoplasms, the extent of disease and adequate clinical therapy

  20. Surveillance for gastrointestinal malignancies

    Ashish K Tiwari; Heather S Laird-Fick; Ramesh K Wali; Hemant K Roy

    2012-01-01

    Gastrointestinal (GI) malignancies are notorious for frequently progressing to advanced stages even in the absence of serious symptoms,thus leading to delayed diagnoses and dismal prognoses.Secondary prevention of GI malignancies through early detection and treatment of cancer-precursor/premalignant lesions,therefore,is recognized as an effective cancer prevention strategy.In order to efficiently detect these lesions,systemic application of screening tests (surveillance) is needed.However,most of the currently used non-invasive screening tests for GI malignancies (for example,serum markers such as alpha-fetoprotein for hepatocellular carcinoma,and fecal occult blood test,for colon cancer) are only modestly effective necessitating the use of highly invasive endoscopy-based procedures,such as esophagogastroduodenoscopy and colonoscopy for screening purposes.Even for hepatocellular carcinoma where non-invasive imaging (ultrasonography) has become a standard screening tool,the need for repeated liver biopsies of suspicious liver nodules for histopathological confirmation can't be avoided.The invasive nature and high-cost associated with these screening tools hinders implementation of GI cancer screening programs.Moreover,only a small fraction of general population is truly predisposed to developing GI malignancies,and indeed needs surveillance.To spare the average-risk individuals from superfluous invasive procedures and achieve an economically viable model of cancer prevention,it's important to identify cohorts in general population that are at substantially high risk of developing GI malignancies (riskstratification),and select suitable screening tests for surveillance in these cohorts.We herein provide a brief overview of such high-risk cohorts for different GI malignancies,and the screening strategies that have commonly been employed for surveillance purpose in them.

  1. Solitary fibrous tumor of the orbit presenting in pregnancy

    Das Jayanta

    2009-01-01

    Full Text Available A 32-year-old woman, three months pregnant, reported with the complaint of protrusion of the right eye for six months. She gave history of rapid protrusion of eyeball for the last two months along with the history of double vision for the last one month. Computer tomography (CT scan revealed a well-defined mass lesion in the intraconal space of the right orbit which was excised through a lateral orbitotomy approach. Histological examination and immunohistochemistry revealed a solitary fibrous tumor, which showed a rapid progression in pregnancy.

  2. Aerosol Filtration Application Using Fibrous Media An Industrial Perspective

    杨传芳

    2012-01-01

    Filtration of aerosol particles using non-woven fibrous media is a common practice for air cleaning. It has found wide applications in industries and our daily lives. This paper overviews some of these applications and provides an industrial perspective. It starts from discussing aerosol filtration theory, followed by a brief review on the advancement of filtration media. After that, filtration applications in respiratory protection, dust collection, and engine in-take air cleaning are elaborated. These are the areas that the author sees as the typical needed ones in China's fast pace economical development endeavor, where air filtration enables the protection of human health, environment and equipment for sustainability.

  3. Pleural spill malign

    The pleural spills are developed because of an alteration in the mechanisms that usually move between 5 and 10 liters of liquid through the space pleural every 24 hours and this is reabsorbed, only leaving 5 to 20 ml present. The causes more common of spill pleural they are: congestive heart failure, bacterial pneumonia, malign neoplasia and pulmonary clot. The causes more common of pleural spill malign in general are: cancer of the lung, cancer of the breast and lymphomas. In the man, cancer of the lung, lymphomas and gastrointestinal cancer. In the woman, cancer of the breast, gynecological cancer and lung cancer. The paper, includes their characteristics, treatments and medicines

  4. A 40-year-old gossypiboma (foreign body granuloma) mimicking a malignant femoral surface tumor

    Sakayama, Kenshi; Fujibuchi, Taketsugu; Kidani, Teruki; Miyawaki, Joji; Yamamoto, Haruyasu [Ehime University School of Medicine, Department of Orthopaedic Surgery, Ehime (Japan); Sugawara, Yoshifumi [Ehime University School of Medicine, Department of Radiology, Ehime (Japan)

    2005-04-01

    The patient was a 61-year-old man who developed gossypiboma of the left thigh and femur resulting in the imaging appearances of a malignant surface tumor. He had a past history of surgery on the left femur for open fracture 40 years previously. Radiographs and CT showed a soft tissue mass with osteolysis and periosteal thickening of the left femur. On MRI, the mass showed heterogeneous signal intensity with contrast enhancement at the periphery, suggesting a malignancy. {sup 99m}Tc-HMDP bone scintigraphy showed a faint ring-like uptake, but thallium -201 scintigraphy did not show any uptake in the tumor. An extensive intralesional excision was performed. Postoperative histopathological examination showed a fibrous foreign body with reactive changes. There were neither viable cells nor atypical giant cells around the foreign body. No malignant change was evident. Based on surgical and histopathological examinations, the tumor was finally diagnosed as gossypiboma related to a retained surgical sponge. (orig.)

  5. Immunotherapy for malignant glioma

    Carter M Suryadevara

    2015-01-01

    Full Text Available Malignant gliomas (MG are the most common type of primary malignant brain tumor. Most patients diagnosed with glioblastoma (GBM, the most common and malignant glial tumor, die within 12-15 months. Moreover, conventional treatment, which includes surgery followed by radiation and chemotherapy, can be highly toxic by causing nonspecific damage to healthy brain and other tissues. The shortcomings of standard-of-care have thus created a stimulus for the development of novel therapies that can target central nervous system (CNS-based tumors specifically and efficiently, while minimizing off-target collateral damage to normal brain. Immunotherapy represents an investigational avenue with the promise of meeting this need, already having demonstrated its potential against B-cell malignancy and solid tumors in clinical trials. T-cell engineering with tumor-specific chimeric antigen receptors (CARs is one proven approach that aims to redirect autologous patient T-cells to sites of tumor. This platform has evolved dramatically over the past two decades to include an improved construct design, and these modern CARs have only recently been translated into the clinic for brain tumors. We review here emerging immunotherapeutic platforms for the treatment of MG, focusing on the development and application of a CAR-based strategy against GBM.

  6. Malignant tumors of childhood

    This book contains 34 papers about malignant tumors. some of the titles are: Invasive Cogenital Mesoblastic Nephroma, Leukemia Update, Unusual Perinatal Neoplasms, Lymphoma Update, Gonadal Germ Cell Tumors in Children, Nutritional Status and Cancer of Childhood, and Chemotherapy of Brain tumors in Children

  7. Malignant melanoma - cutaneous metastases

    Padmavathy L; Rao L; Ethirajan N; Swamy B

    2008-01-01

    Melanoma composed of melanocytes may arise in the skin or other tissues harboring melanocytes, such muco-cutaneous junctions, mucosa including the conjunctiva, iris, choroids and substantia nigra.1 Metastases to the skin and subcutaneous tissues from a malignant melanoma are less common. A case of multiple painless nodules on the body that revealed metastatic deposits of melanoma on histopathological examination is being reported.

  8. Primary malignant intramedullary lymphoma

    A case of primary malignant intramedullary lymphoma, localized in the dorsal part of the spinal cord is presented. The clinical symptoms were associated with motor and sensitive deficit. Clinical investigations excluded the presence of lymphoma in other locations in the central nervous system and the extra neural organs. Postoperative radiotherapy and chemotherapy improved relict neurological symptoms. (authors)

  9. The neuroleptic malignant syndrome

    YAZMAN, Yılmaz Niyazi; İYİGÜN, İbrahim

    1998-01-01

    Neuroleptic Malignant Syndrome (NMS) may occur at any time during the course of therapy in as many as 1 percent of persons who take neuroleptics, particulary haloperidol. In this paper, one case with fever (as high as 39 °C), marked rigidity, tachycardia and consciousness is presented, and clinical presentation, treatment and prognosis of NMS is discussed.

  10. Helminths and malignancy

    Vennervald, Birgitte J; Polman, K.

    2009-01-01

    -malignant change has taken place. Three helminth infections have been classified as definitely carcinogenic to humans (group 1 carcinogens), namely Schistosoma haematobium, which is associated with cancer of the urinary bladder and the food-borne liver flukes Clonorchis sinensis and Opisthorchis viverrini...... coupled with health education, especially in relation to food-borne liver fluke infections....

  11. AIDS and associated malignancies

    Charles; WOOD; William; HARRINGTON; Jr

    2005-01-01

    AIDS associated malignancies (ARL) is a major complication associated with AIDS patients upon immunosuppression.Chronically immunocompromised patients have a markedly increased risk of developing lymphoproliferative disease. In the era of potent antiretrovirals therapy (ARV), the malignant complications due to HIV- 1 infection have decreased in developed nations where ARV is administered, but still poses a major problem in developing countries where HIV- 1incidence is high and ARV is still not yet widely available. Even in ARV treated individuals there is a concern that the prolonged survival of many HIV- 1 carriers is likely to eventually result in an increased number of malignancies diagnosed.Malignancies that were found to have high incidence in HIV-infected individuals are Kaposi's sarcoma (KS), Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). The incidence of NHL has increased nearly 200 fold in HIV-positive patients, and accounts for a greater percentage of AIDS defining illness in the US and Europe since the advent of HAART therapy. These AIDS related lymphomas are distinct from their counterparts seen in HIV- 1 seronegative patients.For example nearly half of all cases of ARL are associated with the presence of a gamma herpesvirus, Epstein Barr virus (EBV) or human herpesvirus-8 (HHV-8)/Kaposi's sarcoma associated herpesvirus (KSHV). The pathogenesis of ARLs is complex. B-cell proliferation driven by chronic antigenemia resulting in the induction of polyclonal and ultimately monoclonal lymphoproliferation may occur in the setting of severe immunosuppression.

  12. Thermoviscoplastic analysis of fibrous periodic composites using triangular subvolumes

    Walker, Kevin P.; Freed, Alan D.; Jordan, Eric H.

    1993-01-01

    The nonlinear viscoplastic behavior of fibrous periodic composites is analyzed by discretizing the unit cell into triangular subvolumes. A set of these subvolumes can be configured by the analyst to construct a representation for the unit cell of a periodic composite. In each step of the loading history, the total strain increment at any point is governed by an integral equation which applies to the entire composite. A Fourier series approximation allows the incremental stresses and strains to be determined within a unit cell of the periodic lattice. The nonlinearity arising from the viscoplastic behavior of the constituent materials comprising the composite is treated as fictitious body force in the governing integral equation. Specific numerical examples showing the stress distributions in the unit cell of a fibrous tungsten/copper metal matrix composite under viscoplastic loading conditions are given. The stress distribution resulting in the unit cell when the composite material is subjected to an overall transverse stress loading history perpendicular to the fibers is found to be highly heterogeneous, and typical homogenization techniques based on treating the stress and strain distributions within the constituent phases as homogeneous result in large errors under inelastic loading conditions.

  13. Electrospun 3D Fibrous Scaffolds for Chronic Wound Repair

    Huizhi Chen

    2016-04-01

    Full Text Available Chronic wounds are difficult to heal spontaneously largely due to the corrupted extracellular matrix (ECM where cell ingrowth is obstructed. Thus, the objective of this study was to develop a three-dimensional (3D biodegradable scaffold mimicking native ECM to replace the missing or dysfunctional ECM, which may be an essential strategy for wound healing. The 3D fibrous scaffolds of poly(lactic acid-co-glycolic acid (PLGA were successfully fabricated by liquid-collecting electrospinning, with 5~20 µm interconnected pores. Surface modification with the native ECM component aims at providing biological recognition for cell growth. Human dermal fibroblasts (HDFs successfully infiltrated into scaffolds at a depth of ~1400 µm after seven days of culturing, and showed significant progressive proliferation on scaffolds immobilized with collagen type I. In vivo models showed that chronic wounds treated with scaffolds had a faster healing rate. These results indicate that the 3D fibrous scaffolds may be a potential wound dressing for chronic wound repair.

  14. Fibrous Fillers to Manufacture Ultra High Ash/Performance Paper

    Dr. VIjay K. Mathur

    2009-04-30

    The paper industry is one of the largest users of energy and emitters of CO2 in the US manufacturing industry. In addition to that, it is facing tremendous financial pressure due to lower cost imports. The fine paper industry has shrunk from 15 million tons per year production to 10 million tons per year in the last 5 years. This has resulted in mill closures and job loses. The AF&PA and the DOE formed a program called Agenda 2020 to help in funding to develop breakthrough technologies to provide help in meeting these challenges. The objectives of this project were to optimize and scale-up Fibrous Fillers technology, ready for commercial deployment and to develop ultra high ash/high performance paper using Fibrous Fillers. The goal was to reduce energy consumption, carbon footprint, and cost of manufacturing paper and related industries. GRI International (GRI) has been able to demonstrate the techno - economic feasibility and economic advantages of using its various products in both handsheets as well as in commercial paper mills. GRI has also been able to develop sophisticated models that demonstrate the effect of combinations of GRI's fillers at multiple filler levels. GRI has also been able to develop, optimize, and successfully scale-up new products for use in commercial paper mills.

  15. Oral potentially malignant disorders: is malignant transformation predictable and preventable?

    I. van der Waal

    2014-01-01

    Leukoplakia is the most common potentially malignant disorder of the oral mucosa. The prevalence is approximately 1% while the annual malignant transformation ranges from 2% to 3%. At present, there are no reliable clinicopathological or molecular predicting factors of malignant transformation that

  16. Transarticular invasion of the sacroiliac joints by malignant pelvic bone tumors

    To describe modes of transarticular invasion, with reference to the size and location of a tumor, the anatomic characteristics of invaded cartilage,and the existence of ankylosis in SI joint. Eleven histologically confirmed malignant pelvic bone tumors involving transarticular invasion of sacroiliac joints, were retrospectively analysed. Transarticular invasion of a joint was defined as involvement of its opposing bones. The anatomic site and size of the tumors were analysed, and invaded sacroiliac joint was divided into upper, middle and lower parts on the basis of the anatomic characteristics of the intervening cartilage: synovial hyaline or fibrous ligamentous. the existence of ankylosis was determined, and transarticular invasion directly across a joint was classified as direct invasion. Extension of tumors around a joint from its periphery to the opposing bone were considered as indirect invasion. All tumors were located near the sacroiliac joint, eight at the ilium and three at the sacrum. Six invasions were indirect and five were direct. Average tumor area was larger in indirect cases than in direct: 191.8 cm2 vs. 69.6 cm2. In all indirect invasions, a huge soft tissue mass abutted onto the peripheral portion of the sacroiliac joint. In five of six cases of indirect transarticular invasion, the upper part of the joint posteriorly located fibrous ligamentous cartilage. In the other, the lower part was invaded, and this involved a detour around the joint space, avoiding the invasion of intervening cartilage. Ankylosis occurred in one of the indirect cases. Among the five cases of direct invasion, there was invasion of the posteriorly located ligamentous fibrous cartilage in three without ankylosis. In the other two cases, involving ankylosis, the synovial hyaline cartilage was invaded directly at the lower part of the joint. Transarticular invasions of sacroiliac joint via fibrous cartilage are most common. Ankylosis of the sacroiliac joint facilitates hyaline

  17. Malignant Melanoma of the Foot

    ... Text Size Print Bookmark Malignant Melanoma of the Foot What is Malignant Melanoma? Melanoma is a cancer ... age groups, even the young. Melanoma in the Foot Melanoma that occurs in the foot or ankle ...

  18. Radiation associated malignant pleural mesothelioma.

    Lerman, Y.; Learman, Y; Schachter, P.; Herceg, E; Lieberman, Y; Yellin, A.

    1991-01-01

    Malignant pleural mesothelioma of epithelial type developed in a 24 year old woman, 20 years after radiotherapy for Hodgkin's disease. This case and a review of published cases indicate that radiation may induce malignant mesothelioma.

  19. Image diagnosis of malignant mesothelioma

    3 cases of malignant mesothelioma confirmed by pathological examination were reported. CT showed solid mass with moderate enhancement by contrast medium. CT appears to be a very useful tool to make a diagnosis of malignant mesothelioma. (author)

  20. Fibrous dysplasia associated with intramuscular myxoma(mazabraud's syndrome) : a case report

    Mazabraud's syndrome, the etiology of which is unknown, is a rare benign disease, characterized by the association of intramuscular myxoma and fibrous dysplasia of bone, usually polyostotic. We describe a case of Mazabraud's syndrome in which with two intramuscular myxomas of the forearm were associated with polyostotic fibrous dysplasia

  1. Fibrous monoliths: Economic ceramic matrix composites from powders[Final report]; FINAL

    The project was to develop and perform pilot-scale production of fibrous monolith composites. The principal focus of the program was to develop damage-tolerant, wear-resistant tooling for petroleum drilling applications and generate a basic mechanical properties database on fibrous monolith composites

  2. Low level hydrogen peroxide generation from a nonwoven fibrous pectin-cellulose blend

    Fibrous pectic-cellulose (FPC) (cellulose blended with primary cell wall pectin at 2 percent by weight of pectin) is product made from naturally occurring plant fibers. FPC is a fibrous mixture of polysaccharides with a low percent by weight of pectin-based primary cell wall and lipid components att...

  3. High-surface-area silica nanospheres (KCC-1) with a fibrous morphology

    Polshettiwar, Vivek

    2010-08-02

    Fibrous nanosilica: A new family of high-surface-area silica nanospheres (KCC-1) have been prepared (see picture). KCC-1 features excellent physical properties, including high surface area, unprecedented fibrous surface morphology, high thermal (up to 950 °C) and hydrothermal stabilities, and high mechanical stability. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Fibrous scar in the infrapatellar fat pad after arthroscopy. MR imaging

    We describe the MR appearance of fibrous scars in the infrapatellar fat pad after arthroscopy. The subjects were 96 patients who underwent arthroscope-assisted anterior cruciate ligament (ACL) reconstruction and were examined by oblique sagittal MR imaging at different follow-up intervals. Two observers evaluated the characteristics of the fibrous scars in the infrapatellar fat pad. All fibrous scars with low signal intensity were accentuated at the portal and coursed horizontally through the infrapatellar fat pad. The fibrous scar within the fat pad occurred and peaked within 6 months after arthroscopy. It then subsided gradually and had disappeared by one year later in nearly half of the patients. Identifying MR imaging characteristics of fibrous scars in the fat pad after arthroscopy may be clinically helpful to differentiate these scars from other abnormalities that involve the infrapatellar fat pad. (author)

  5. Diffuse malignant pleural mesothelioma in an urban hospital: Clinical spectrum and trend in incidence over time

    This retrospective analysis reviews the clinical experience of a major urban referral hospital with diffuse malignant pleural mesothelioma during the 14-year period from 1973 through 1986. Seventy-five cases of definite or equivocal mesothelioma were identified. There were four cases of primary malignant peritoneal mesothelioma, seven cases of benign fibrous mesothelioma, and 64 cases of diffuse malignant pleural mesothelioma. In 43 cases (67%) of diffuse malignant pleural mesothelioma, there was historic evidence of asbestos exposure. In 21 cases (33%), there was no known history of asbestos exposure. An increase in annual incidence of diffuse malignant pleural mesothelioma was observed over the study period, from three cases in 1973 to ten cases in 1986. Despite greater awareness of this disease, the diagnosis remains a difficult one to establish given the nonspecific symptoms, signs and radiographic appearance, variable histologic appearance, and poor diagnostic sensitivity and specificity of thoracentesis and closed pleural biopsy. Thoracotomy, thoracoscopy, and CT-guided needle biopsies gave higher yields and are the diagnostic measures of choice when diffuse malignant pleural mesothelioma is suspected

  6. STAT6 immunohistochemistry is helpful in the diagnosis of solitary fibrous tumors.

    Yoshida, Akihiko; Tsuta, Koji; Ohno, Makoto; Yoshida, Masayuki; Narita, Yoshitaka; Kawai, Akira; Asamura, Hisao; Kushima, Ryoji

    2014-04-01

    Solitary fibrous tumor (SFT) is an uncommon fibroblastic neoplasm. Although histologic characteristics and frequent CD34 expression allow for an accurate diagnosis in the majority of SFT cases, a wide histologic spectrum and an occasional unexpected immunophenotype may pose diagnostic challenges. Molecular analyses have discovered that almost all SFTs harbor an NAB2-STAT6 fusion gene, which is considered specific to this tumor type. Recent studies have suggested that STAT6 immunohistochemistry is a reliable surrogate for detection of the fusion gene. Our aim was to validate these findings by examining a large number of SFT cases and a broad array of 30 different types of non-SFT tumors. A total of 49 SFTs with a range of histologic characteristics and 159 benign or malignant tumors that can mimic SFTs were retrieved and stained for STAT6. All 49 SFTs (100%) showed STAT6 expression that was restricted in the nucleus, mostly in a diffuse and strong manner, irrespective of the tumor sites and histologic patterns. The staining was uniform in most cases but was heterogenous in about 20% of the cases in which zonal staining attenuation was observed, likely reflecting variability in fixation or tissue ischemia. In contrast, only 4 non-SFT tumors (2.5%) exhibited weak nuclear STAT6 expression, whereas the remaining 155 cases showed no staining or often weak reactivity in both the cytoplasm and the nucleus. Therefore, nuclear STAT6 immunoreactivity is a highly sensitive and specific marker of SFTs and can be helpful when diagnosis is inconclusive by conventional methods. PMID:24625420

  7. Microstructure and properties of nano-fibrous PCL-b-PLLA scaffolds for cartilage tissue engineering

    L He

    2009-10-01

    Full Text Available Nano-fibrous scaffolds which could potentially mimic the architecture of extracellular matrix (ECM have been considered a good candidate matrix for cell delivery in tissue engineering applications. In the present study, a semicrystalline diblock copolymer, poly(e-caprolactone-block-poly(L-lactide (PCL-b-PLLA, was synthesized and utilized to fabricate nano-fibrous scaffolds via a thermally induced phase separation process. Uniform nano-fibrous networks were created by quenching a PCL-b-PLLA/THF homogenous solution to -20ºC or below, followed by further gelation for 2 hours due to the presence of PLLA and PCL microcrystals. However, knot-like structures as well as continuously smooth pellicles appeared among the nano-fibrous network with increasing gelation temperature. DSC analysis indicated that the crystallization of PCL segments was interrupted by rigid PLLA segments, resulting in an amorphous phase at high gelation temperatures. Combining TIPS (thermally induced phase separation with salt-leaching methods, nano-fibrous architecture and interconnected pore structures (144±36 mm in diameter with a high porosity were created for in vitro culture of chondrocytes. Specific surface area and protein adsorption on the surface of the nano-fibrous scaffold were three times higher than on the surface of the solid-walled scaffold. Chondrocytes cultured on the nano-fibrous scaffold exhibited a spherical condrocyte-like phenotype and secreted more cartilage-like extracellular matrix (ECM than those cultured on the solid-walled scaffold. Moreover, the protein and DNA contents of cells cultured on the nano-fibrous scaffold were 1.2-1.4 times higher than those on the solid-walled scaffold. Higher expression levels of collagen II and aggrecan mRNA were induced on the nano-fibrous scaffold compared to on the solid-walled scaffold. These findings demonstrated that scaffolds with a nano-fibrous architecture could serve as superior scaffolds for cartilage tissue

  8. Hyaluronan in human malignancies

    Sironen, R.K. [Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Department of Pathology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland); Tammi, M.; Tammi, R. [Institute of Biomedicine, Anatomy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Auvinen, P.K. [Department of Oncology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland); Anttila, M. [Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Department of Gynecology and Obstetrics, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland); Kosma, V-M., E-mail: Veli-Matti.Kosma@uef.fi [Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Department of Pathology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland)

    2011-02-15

    Hyaluronan, a major macropolysaccharide in the extracellular matrix of connective tissues, is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of various human tumors and modulates intracellular signaling pathways, cell proliferation, motility and invasive properties of malignant cells. Experimental and clinicopathological evidence highlights the importance of hyaluronan in tumor growth and metastasis. A high stromal hyaluronan content is associated with poorly differentiated tumors and aggressive clinical behavior in human adenocarcinomas. Instead, the squamous cell carcinomas and malignant melanomas tend to have a reduced hyaluronan content. In addition to the stroma-cancer cell interaction, hyaluronan can influence stromal cell recruitment, tumor angiogenesis and epithelial-mesenchymal transition. Hyaluronan receptors, hyaluronan synthases and hyaluronan degrading enzymes, hyaluronidases, are involved in the modulation of cancer progression, depending on the tumor type. Furthermore, intracellular signaling and angiogenesis are affected by the degradation products of hyaluronan. Hyaluronan has also therapeutic implications since it is involved in multidrug resistance.

  9. Malignant melanoma - cutaneous metastases

    Padmavathy L

    2008-01-01

    Full Text Available Melanoma composed of melanocytes may arise in the skin or other tissues harboring melanocytes, such muco-cutaneous junctions, mucosa including the conjunctiva, iris, choroids and substantia nigra. Metastases to the skin and subcutaneous tissues from a malignant melanoma are less common. A case of multiple painless nodules on the body that revealed metastatic deposits of melanoma on histopathological examination is being reported.

  10. Malignant melanoma - cutaneous metastases.

    L, Padmavathy; L, Lakshmana Rao; N, Ethirajan; B, Krishna Swamy

    2008-01-01

    Melanoma composed of melanocytes may arise in the skin or other tissues harboring melanocytes, such muco-cutaneous junctions, mucosa including the conjunctiva, iris, choroids and substantia nigra.1 Metastases to the skin and subcutaneous tissues from a malignant melanoma are less common. A case of multiple painless nodules on the body that revealed metastatic deposits of melanoma on histopathological examination is being reported. PMID:19882041

  11. Epidemiology of ovarian malignancies

    Akanksha Sood

    2016-01-01

    Conclusions: The epidemiology and presentation of ovarian tumours has remained unchanged since last 3 decades. Nulliparity is not as significant a factor in the aetiology of ovarian malignancy however contraception leading to anovulatory cycles (OC pills may have a protective role. Infertility can be suggested as a risk factor but the treatment for infertility and its role in oncogenesis remains controversial. [Int J Reprod Contracept Obstet Gynecol 2016; 5(1.000: 186-193

  12. Hypercoagulability in hematological malignancies

    Middeldorp, S.; Oers, van, M.H.J.; Biemond, B.J.; Lauw, M.N.

    2015-01-01

    Patients with cancer are at high risk for venous thrombosis, the undesired formation of blood clots within the veins. Historically, this high risk was mainly attributed to patients with solid tumors, but recent studies have indicated that the risk is at least as high or even higher in patients with hematological malignancies, such as lymphoma, multiple myeloma and leukemia, especially acute lymphoblastic leukemia. Venous thrombosis can cause life-long morbidity or can be fatal, and requires a...

  13. Malignant melanoma of choroid

    Manohar S

    1991-01-01

    Full Text Available Four cases of malignant melanoma of the choroid are reported due to rarity of the condition in India. One of the cases presented with Naevus of Ota. All the cases had typical clinical and investigative features. All cases were enucleated. Histopathologically three of them were of mixed type and one was of the epithelioid type. Two of the cases were seen in patients below 40 years of age.

  14. Pembrolizumab in Treating Patients With Malignant Mesothelioma

    2016-05-10

    Biphasic Mesothelioma; Epithelioid Mesothelioma; Peritoneal Malignant Mesothelioma; Pleural Biphasic Mesothelioma; Pleural Epithelioid Mesothelioma; Pleural Malignant Mesothelioma; Pleural Sarcomatoid Mesothelioma; Recurrent Peritoneal Malignant Mesothelioma; Recurrent Pleural Malignant Mesothelioma; Sarcomatoid Mesothelioma

  15. Radioimmunotherapy of malignant gliomas

    Despite all technical advances (intraoperative resection control, fluorescence guided resection, advances in external beam radiation techniques) and new consolidated findings on systemic chemotherapy treatment of malignant gliomas with conventional therapeutic modalities (surgery, radiation therapy and chemotherapy) is still highly unfavourable. Total tumor erradication is impossible due to tumor infiltrations into the normal brain and the limitations given by the limited tolerance of surrounding brain tissue. New treatment strategies, therefore, aim for a more selective destruction of tumor cells. Malignant glioma cells selectively express several antigens or receptors which are not or only to a minor extent present in normal brain tissue. Administration of radiolabelled monoclonal antibodies, especially when given locoregionally, targeting these tumor-specific antigens offers an innovative therapeutic strategy that has recently demonstrated encouraging antitumor effects and acceptable toxicity in many phase I/II clinical trials. This review offers a comprehensive summary of own experiences and results of clinical trials reported in the literature dealing with radioimmunotherapy of malignant glioma and highlights future plans to further develop this therapeutic strategy. (orig.)

  16. Asbestos-related malignancy

    Talcott, J.A.; Antman, K.H.

    1988-05-01

    Asbestos-associated malignancies have received significant attention in the lay and medical literature because of the increasing frequency of two asbestos-associated tumors, lung carcinoma and mesothelioma; the wide distribution of asbestos; its status as a prototype environmental carcinogen; and the many recent legal compensation proceedings, for which medical testimony has been required. The understanding of asbestos-associated carcinogenesis has increased through study of animal models, human epidemiology, and, recently, the application of modern molecular biological techniques. However, the detailed mechanisms of carcinogenesis remain unknown. A wide variety of malignancies have been associated with asbestos, although the strongest evidence for a causal association is confined to lung cancer and mesothelioma. Epidemiological studies have provided evidence that both the type of asbestos fiber and the industry in which the exposure occurs may affect the rates of asbestos-associated cancers. It has been shown that asbestos exerts a carcinogenic effect independent of exposure to cigarette smoking that, for lung cancers, is synergistically enhanced by smoking. Other questions remain controversial, such as whether pulmonary fibrosis necessarily precedes asbestos-associated lung cancer and whether some threshold level of exposure to asbestos (including low-dose exposures that may occur in asbestos-associated public buildings) may be safe. Mesothelioma, the most closely asbestos-associated malignancy, has a dismal natural history and has been highly resistant to therapy. However, investigational multi-modality therapy may offer benefit to some patients. 179 references.

  17. [Malignant biliary obstruction].

    Hucl, Tomáš

    2016-01-01

    Pancreatic cancer and cholangiocarcinoma are the most common causes of malignant biliary obstruction. They are diseases of increasing incidence and unfavorable prognosis. Only patients with localized disease indicated for surgery have a chance of long-term survival. These patients represent less than 20 % of all patients, despite the progress in our diagnostic abilities.Locally advanced and metastatic tumors are treated with palliative chemotherapy or chemoradiotherapy; the results of such treatments are unsatisfactory. The average survival of patients with unresectable disease is 6 months and only 5-10 % of patients survive 5 years.Biliary drainage is an integral part of palliative treatment. Endoscopically or percutaneosly placed stents improve quality of life, decrease cholestasis and pruritus, but do not significantly improve survival. Biliary stents get occluded over time, possibly resulting in acute cholangitis and require repeated replacement.Photodynamic therapy and radiofrequency ablation, locally active endoscopic methods, have been increasingly used in recent years in palliative treatment of patients with malignant biliary obstruction. In photodynamic therapy, photosensitizer accumulates in tumor tissue and is activated 48 hours later by light of a specific wave length. Application of low voltage high frequency current during radiofrequency ablation results in tissue destruction by heat. Local ablation techniques can have a significant impact in a large group of patients with malignant biliary obstruction, leading to improved prognosis, quality of life and stent patency. PMID:26898789

  18. Malignant biliary obstruction

    This paper assesses the value of CT in predicting surgical resectability of tumors in patients with malignant biliary obstruction. A retrospective analysis was performed on 320 consecutive patients with malignant biliary obstruction over a 3-1/2-year period. Most patients were treated nonoperatively. Fifty-one patients fulfilled the selection criteria of surgical exploration, pathological confirmation of malignancy, and prepoperative CT scans available for review. The CT scans were reviewed by a blinded reader and assessed for surgical resectability of tumors. There were 32 patients with pancreatic adenocarcinoma, 6 with ampullary carcinoma, 5 with cholangiocarcinoma, 2 with gallbladder carcinoma, and 6 with other pathologic diagnoses. Of 36 patients thought to have unresectable tumors based on CT findings, 32 were found to have surgically unresectable tumors (positive predictive value, 89%). Of 15 patients thought to have resectable tumors based on CT findings, 11 had surgically resectable tumors (positive predictive value, 73%). CT missed positive duodenal lymph nodes in 2 patients, portal vein infiltration in 1 patient, and small liver metastases in 1 patient

  19. Malignant intraocular tumors

    The role of the radiation therapist in the management of malignant intraocular tumors is changing. With more active identification of malignant intraocular tumors, and a better recognization of the manner in which one can deal with problems of radiation sensitivity, radiation techniques of all sorts will be more actively employed in the treatment of these tumors. Special techniques must be selected for appropriate circumstances of management in order to diminish to an absolute minimum the impact upon the lens, the impact upon visual acuity and the impact upon the cornea. Cobalt-60 plaques are being used more commonly in the treatment of melanomas of the choroid, and the role for radiation therapy in the management of retinoblastoma is changing markably to where it may be used as the primary treatment program rather than enucleation. In metastatic disease involving the uveal tract, radiation therapy has assumed the most important role for management. Chemotherapy should be considered as an active adjuvant in the management of not only those individuals with retinoblastoma but also in those identified circumstances where metastases to the uveal tract are being treated. The role for chemotherapy or immunotherapy in malignant melanoma is unclear

  20. EXTRA PLEURAL SOLITARY FIBROUS TUMOR: A REPORT OF TWO CASES

    Meenakumari

    2014-12-01

    Full Text Available : Solitary fibrous tumor (SFT belongs to a group of mesenchymal tumors, first described as a primary spindle cell tumor of the pleura in 1931. Recently, SFT has been reported in various locations with no relation to serosal surface. We describe two such cases in unusual sites of orbit and nasal cavity. Histopathologically, the tumors had a disorganized or “patternless” arrangement of spindle cells in a collagenous background and prominent vascular channels of varying sizes. Immunohistochemically both tumours showed CD 34 positivity. The two patients had benign clinical course with limited follow-up. SFT should be included in the differential diagnosis of spindle cell tumors arising in the nasal cavity and orbit.

  1. On the thermal conductivity of ceramic fibrous and rigid insulations

    This chapter reports on an extensive experimental program performed to study the influence of pressure, temperature and coolant media on the thermal conductivities of fibrous and rigid materials. Explains that small specimens were installed between electrically heated plates, and the stationary method of Poensen was applied. Full-size systems were tested in a high pressure wind tunnel in a horizontal position at different pressures, temperatures, media, and axial pressure gradients. Determines the requirements for insulating systems of hot gas ducts. Shows the influence of heat radiation in the case of Kaowool. Finds that owing to the value of the conductivity of the gas, the results are much higher in helium than in air. Indicates that the investigations on dense rigid samples showed a small, or nearly negligible, influence of pressure and medium due to the high conductivity of the material

  2. A theoretical analysis of local thermal equilibrium in fibrous materials

    Tian Mingwei

    2015-01-01

    Full Text Available The internal heat exchange between each phase and the Local Thermal Equilibrium (LTE scenarios in multi-phase fibrous materials are considered in this paper. Based on the two-phase heat transfer model, a criterion is proposed to evaluate the LTE condition, using derived characteristic parameters. Furthermore, the LTE situations in isothermal/adiabatic boundary cases with two different heat sources (constant heat flux and constant temperature are assessed as special transient cases to test the proposed criterion system, and the influence of such different cases on their LTE status are elucidated. In addition, it is demonstrated that even the convective boundary problems can be generally estimated using this approach. Finally, effects on LTE of the material properties (thermal conductivity, volumetric heat capacity of each phase, sample porosity and pore hydraulic radius are investigated, illustrated and discussed in our study.

  3. Carbon-Based Fibrous EDLC Capacitors and Supercapacitors

    C. Lekakou

    2011-01-01

    Full Text Available This paper investigates electrochemical double-layer capacitors (EDLCs including two alternative types of carbon-based fibrous electrodes, a carbon fibre woven fabric (CWF and a multiwall carbon nanotube (CNT electrode, as well as hybrid CWF-CNT electrodes. Two types of separator membranes were also considered. An organic gel electrolyte PEO-LiCIO4-EC-THF was used to maintain a high working voltage. The capacitor cells were tested in cyclic voltammetry, charge-discharge, and impedance tests. The best separator was a glass fibre-fine pore filter. The carbon woven fabric electrode and the corresponding supercapacitor exhibited superior performance per unit area, whereas the multiwall carbon nanotube electrode and corresponding supercapacitor demonstrated excellent specific properties. The hybrid CWF-CNT electrodes did not show a combined improved performance due to the lack of carbon nanotube penetration into the carbon fibre fabric.

  4. Polyelectrolyte-complex nanostructured fibrous scaffolds for tissue engineering

    In the current work, polyelectrolyte complex (PEC) fibrous scaffolds for tissue engineering have been synthesized and a mechanism of their formation has been investigated. The scaffolds are synthesized using polygalacturonic acid and chitosan using the freeze drying methodology. Highly interconnected pores of sizes in the range of 5-20 μm are observed in the scaffolds. The thickness of the fibers was found to be in the range of 1-2 μm. Individual fibers have a nanogranular structure as observed using AFM imaging. In these scaffolds, PEC nanoparticles assemble together at the interface of ice crystals during freeze drying process. Further investigation shows that the freezing temperature and concentration have a remarkable effect on structure of scaffolds. Biocompatibility studies show that scaffold containing chitosan, polygalacturonic acid and hydroxyapatite promotes cell adhesion and proliferation. On the other hand, cells on scaffolds fabricated without hydroxyapatite nanoparticles showed poor adhesion.

  5. Solitary fibrous tumor arising in an intrathoracic goiter

    Larsen, Stine Rosenkilde; Godballe, Christian; Krogdahl, Annelise

    2010-01-01

    BACKGROUND: Solitary fibrous tumor (SFT) is a rare spindle cell tumor most often found in the mediastinal pleura. Nineteen cases of SFT arising in the thyroid gland have been reported. We report a case of SFT of the thyroid gland with immunohistochemical and cytogenetic investigation. SUMMARY: A 58....... CONCLUSION: The histological appearance and immunohistochemical reaction pattern of SFT is characteristic. The entity should be considered when dealing with a spindle cell lesion in the thyroid gland. All cases of this site of origin reported have had a benign clinical course. As only a small number of cases......-year-old man had pulmonary symptoms, thought to be asthma. Computed tomographic scan revealed a large goiter with a solid hyperechoic nodule. The results of thyroid function tests were normal. Microscopically, the lesion was composed of fibroblast-like spindle cells in a patternless growth. Cellular...

  6. Hyperostotic esthesioneuroblasma: Rare variant and fibrous dysplasia mimicker

    A 65-year-old male presented with a 3-year history of orbital symptoms. An imaging-based diagnosis of fibrous dysplasia involving the skull base was made at another institution. CT showed a diffuse sinonasal mass and ground-glass appearance of the bones of the anterior skull base with bony defects and mucocele formation. MRI demonstrated an accompanying intracranial and orbital rind of soft tissue mass along the hyperostotic bones. FDG-PET showed corresponding intense hypermetabolism. Small cysts were observed at the tumor-brain interface. Biopsy revealed esthesioneuroblastoma with bone infiltration that is compatible with the hyperostotic variant of esthesioneuroblastoma. There are a few cases of hyperostotic esthesioneuroblastoma reported in the literature.

  7. Hyperostotic esthesioneuroblasma: Rare variant and fibrous dysplasia mimicker

    Ahmed, Manzoor [Neuroradiology Section, Imaging Institute, Cleveland Clinic Foundation, Cleveland (United States); Knott, Phillip Daniel [Director of Facial Plastic and Reconstructive Surgery, Associate Professor of Otolaryngology, UCSF School of Medicine, San Fransisco (United States)

    2014-02-15

    A 65-year-old male presented with a 3-year history of orbital symptoms. An imaging-based diagnosis of fibrous dysplasia involving the skull base was made at another institution. CT showed a diffuse sinonasal mass and ground-glass appearance of the bones of the anterior skull base with bony defects and mucocele formation. MRI demonstrated an accompanying intracranial and orbital rind of soft tissue mass along the hyperostotic bones. FDG-PET showed corresponding intense hypermetabolism. Small cysts were observed at the tumor-brain interface. Biopsy revealed esthesioneuroblastoma with bone infiltration that is compatible with the hyperostotic variant of esthesioneuroblastoma. There are a few cases of hyperostotic esthesioneuroblastoma reported in the literature.

  8. An Empirical Formula for Sound Absorption of Fibrous Materials

    ZHANG Xin-an

    2008-01-01

    The sound absorption coefficient (SAC) curves of the nonwovens, fabrics, and thick fibrous layers with the frequency in the range of 125-3 200 Hz and cavity distances of 5 cm, 10 cm, 20 cm, 30 cm and 40 cm were measured.Based on analysis, it is found that the SAC is actually in direct proportion to the relative vibration amplitude of the sound wave, resulting in obtaining a mathematical expression showing that the SAC changes with the frequency for a given material. Additionally, a good corresponding relation between the maximal SAC and the permeability of the materials is discovered, thus an empirical formula is established. As a result, a complete SAC formula has been developed. In this formula, the SAC is solely a function of the sound wave frequency and permeability of the material. In comparison with sound absorption spectra of several materials, the calculated results and results measured with the formula coincide well with each other.

  9. Fibrous synovial sarcoma of the foot - a case report

    The authors report a case of a 24 year-old female patient with a three-month history of pain and enlargement of the left hallux. Ultrasound showed a heterogeneous, hypoechoic solid soft tissue mass with cystic areas and calcification in the dorsum of the left hallux. A tendinous structure was identified within the lesion but no evidence of involvement of adjacent osseous structures was found. Doppler ultrasound revealed central and peripheral hypervascularization of the lesion. Magnetic resonance imaging demonstrated a solid soft tissue mass containing a tendinous structure. The lesion appeared as an intermediate signal intensity structure on T1 images, high signal intensity on T2 images, and showed marked enhancement after intravenous administration of gadolinium. No osseous lesions were identified. The patient was submitted to surgical resection of the lesion in the dorsum of the left hallux and the pathology results revealed a monophasic fibrous synovial sarcoma. (author)

  10. Bending failure of laminated fibrous composite plates with a hole

    Kwon, Y.W.; Yang, S.T. [Naval Postgraduate School, Monterey, CA (United States). Dept. of Mechanical Engineering

    1995-08-01

    This study investigates failure modes and failure strengths of laminated fibrous composite plates with stress concentration and subjected to bending loads. Graphite/epoxy composites are used for the present study. Lamina material properties, such as stiffness and strength, of the composite are determined from experiments. A series of four-point bending tests are conducted for laminated, graphite/epoxy composite plates with and without a hole to examine their failure modes and strengths. The paper compares different failure modes and strengths of various composite specimens. In addition, finite element analyses are performed to compute stress distributions around holes of the composite plates subjected to bending loads. Numerically predicted failure loads agree well with experimental results.

  11. Determination of physical properties of fibrous thermal insulation

    Jeandel G.

    2012-10-01

    Full Text Available The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a device developed in house. The radiative properties of the material are determined by an inverse method based on measurements of transmittance and reflectance using a FTIR spectrometer and by solving the equation of radiative heat transfer. These measures are compared to results of numerical simulations.

  12. Determination of physical properties of fibrous thermal insulation

    Tilioua, A.; Libessart, L.; Joulin, A.; Lassue, S.; Monod, B.; Jeandel, G.

    2012-10-01

    The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET) with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool) are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a device developed in house. The radiative properties of the material are determined by an inverse method based on measurements of transmittance and reflectance using a FTIR spectrometer and by solving the equation of radiative heat transfer. These measures are compared to results of numerical simulations.

  13. Alumina composites for oxide/oxide fibrous monoliths

    Most work on ceramic fibrous monoliths (FMs) has focused on the Si3N4/BN system. In an effort to develop oxidation-resistant FMs, several oxide systems have recently been examined. Zirconia-toughened alumina and alumina/mullite appear to be good candidates for the cell phase of FMs. These composites offer higher strength and toughness than pure alumina and good high-temperature stability. By combining these oxides, possibly with a weaker high-temperature oxide as the cell-boundary phase, it should be possible to product a strong, resilient FM that exhibits graceful failure. Several material combinations have been examined. Results on FM fabrication and microstructural development are presented

  14. The Surface Groups and Active Site of Fibrous Mineral Materials

    DONG Fa-qin; WAN Pu; FENG Qi-ming; SONG Gong-bao; PENG Tong-jiang; LI Ping; LI Guo-wu

    2004-01-01

    The exposed and transformed groups of fibrous brucite,wollastonite,chrysotile asbestos,sepiolite,palygorskite,clinoptilolite,crocidolite and diatomaceous earth mineral materials are analyzed by IR spectra after acid and alikali etching,strong mechanical and polarity molecular interaction.The results show the active sites concentrate on the ends in stick mineral materials and on the defect or hole edge in pipe mineral materials.The inside active site of mineral materials plays a main role in small molecular substance.The shape of minerals influence their distribution and density of active site.The strong mechanical impulsion and weak chemical force change the active site feature of minerals,the powder process enables minerals exposed more surface group and more combined types.The surface processing with the small polarity molecular or the brand of middle molecular may produce ionation and new coordinate bond,and change the active properties and level of original mineral materials.

  15. Biocompatibility assessment of fibrous nanomaterials in mammalian embryos.

    Munk, Michele; Camargo, Luiz S A; Quintão, Carolina C R; Silva, Saulo R; Souza, Eliza D; Raposo, Nádia R B; Marconcini, Jose M; Jorio, Ado; Ladeira, Luiz O; Brandão, Humberto M

    2016-07-01

    Currently there is a growing interest in the use of nanotechnology in reproductive medicine and reproductive biology. However, their toxic effects on mammalian embryos remain poorly understood. In this work, we evaluate the biocompatibility of two fibrous nanomaterials (NMs): cotton cellulose nanofibers (CNF) and carboxylated multiwalled carbon nanotubes (MWCNT-COOH), by performing an investigation of the embryonic development, gene expression (biomarkers focused on cell stress, apoptosis and totipotency) and in situ apoptosis in bovine embryos. Exposure to NMs did not interfere in preimplantation development or in the incidence of apoptosis in the bovine embryo, but they did affect the gene expression. The results presented are important for an understanding of the toxicity of cotton CNF and MWCNT-COOH on mammalian embryos. To our knowledge, we report the first evaluation of biocompatibility between these NMs on preimplantation embryos, which may open a new window for reproductive biomedical applications. PMID:26949162

  16. Configuration of Fibrous and Adipose Tissues in the Cavernous Sinus

    Liang, Liang; Gao, Fei; Xu, Qunyuan; Zhang, Ming

    2014-01-01

    Objective Three-dimensional anatomical appreciation of the matrix of the cavernous sinus is one of the crucial necessities for a better understanding of tissue patterning and various disorders in the sinus. The purpose of this study was to reveal configuration of fibrous and adipose components in the cavernous sinus and their relationship with the cranial nerves and vessels in the sinus and meningeal sinus wall. Materials and Methods Nineteen cadavers (8 females and 11 males; age range, 54–89 years; mean age, 75 years) were prepared as transverse (6 sets), coronal (3 sets) and sagittal (10 sets) plastinated sections that were examined at both macroscopic and microscopic levels. Results Two types of the web-like fibrous networks were identified and localized in the cavernous sinus. A dural trabecular network constituted a skeleton-frame in the sinus and contributed to the sleeves of intracavernous cranial nerves III, IV, V1, V2 and VI. A fine trabecular network, or adipose tissue, was the matrix of the sinus and was mainly distributed along the medial side of the intracavernous cranial nerves, forming a dumbbell-shaped adipose zone in the sinus. Conclusions This study revealed the nature, fine architecture and localization of the fine and dural trabecular networks in the cavernous sinus and their relationship with intracavernous cranial nerves and vessels. The results may be valuable for better understanding of tissue patterning in the cranial base and better evaluation of intracavernous disorders, e.g. the growth direction and extent of intracavernous tumors. PMID:24586578

  17. Seven inflammatory pseudotumors in a girl and six boys

    This is a retrospective study of a girl and six boys aged 5-15.5 years (mean, 10.7 years) with benign inflammatory pseudotumors involving the lung, stomach, abdomen, mesentery, retroperitoneum, and testis. All but one of the tumors were resected. Recurrence in one case prompted secondary resection. One child died of secondary aortic bleeding; the others are fine. The tumors are characterized by proliferative fibrovascular tissue and inflammatory cells. Histiocytes, plasma cells, or sclerotic elements may predominate. Tumor etiology is unknown. Differentiation from malignant fibrous histiocytoma may be difficult pathologically, and differentiation from a malignant tumor (e.g., lymphoma, neuroblastoma) or an abscess may be difficult radiologically

  18. A case of dedifferentiated liposarcoma showing a biphasic pattern on 2-deoxy-2-F18- fluoro-D-glucose positron emission tomography/ computed tomography

    Manabu Hoshi

    2013-04-01

    Full Text Available Integrated 2-deoxy-2-F18-fluoro-D-glucose positron emission tomography combined with computed tomography (FDG-PET/CT has been used in the field of soft tissue sarcoma. We report an 81-year-old man with dedifferentiated liposarcoma in the left thigh, which was composed of well-differentiated liposarcoma and pleomorphic malignant fibrous histiocytoma. As well as other radiological modalities, FDG-PET was able to demonstrate a biphasic signal pattern composed of well-differentiated liposarcoma and dedifferentiated area, being consistent with the histological grade of malignancy.

  19. {sup 99m}Tc-HMDP accumulation in soft tissue tumor

    Momose, Mitsuhiro [Shinshu Univ., Matsumoto, Nagano (Japan). School of Medicine

    2000-11-01

    Accumulation with bone scintigraphy using technetium-99m hydroxymethylene diphosphonate ({sup 99m}Tc-HMDP) in 68 cases with radiographically or pathologically verified soft tissue tumor was examined. Radiographical or histopathologic diagnoses of the 68 cases included; 14 lipomas, 11 liposarcomas, 11 neurinomas or neurofibromas, 6 malignant lymphomas, 5 malignant fibrous histiocytomas, 5 hemangioma, rhabdomyosarcomas, 2 Langerhans cell histiocytoses, 2 desmoid tumors and one each of neuroblastoma, hemangiopericytoma, angiomyxoma, plasmacytoma, liomyosarcoma, lymphangioma, fibrosarcoma, elastofibroma, synovial sarcoma, and ganglion. Thirty-seven (54%) showed positive accumulation and 31 were negative. One half of soft tissue tumors can be accumulated by {sup 99m}Tc-HMDP. (author)

  20. Myositis Ossificans Mimicking Sarcoma, the Importance of Diagnostic Imaging – Case Report

    Myositis ossificans is localized inflammatory process affecting skeletal muscles. Very rarely it can affect one of the neck muscles and present as a neck tumor, it can be misdiagnosed as the clinical, radiological and histological examinations can mimic a sarcoma. We report a 29 year old female patient with neck tumor suspected to be a sarcoma who underwent full diagnostics imaging and open bipsy with histopatological examination, afterwards surgical excision was performed. The aim of this study was to present the differential diagnosis based on diagnostics imaging between MO and malignant tumors, such as parosteal sarcoma, synovial sarcoma and malignant fibrous histiocytoma

  1. CT findings of retroperitoneal masses

    Lee, Sung Moon; Huh, Jin Do; Kim, Ho Joon; Joh, Young Duk; Chun, Byung Hee [Kosin Medical College, Busan (Korea, Republic of); Woo, Seong Ku; Suh, Soo Jhi [School of Medicine, Keimyung University, Daegu (Korea, Republic of)

    1987-10-15

    Retrospective analysis of forty one retroperitoneal masses was made with computed tomography. All cases were confirmed pathologically by operation or needle aspiration biopsy. The cases were; 14 abscesses, 2 leiomyosarcomas, 2 rhabdomyosarcomas, 2 liposarcomas, 1 undifferentiated sarcoma, 3 endodermal sinus tumors, 4 teratomas, 2 neurofibromas, 1 neurilemoma, 3 neuroblastomas, 4 malignant lymphomas, 2 malignant fibrous histiocytomas and 1 hemangiopericytoma. Tumors originated from urinary tract and pancreas were not included. Findings favor tumor rather than inflammation were; large lobulated soft tissue mass with eccentric or heterogeneous low density, thick cavity wall, disruption of fascial planes, regional lymphnode enlargement and distant metastasis.

  2. Uncommon breast lesions. Radiologic and pathologic findings

    To illustrate the radiologic findings in several uncommon breast and infrequent diseases that present with unusual mammographic images. We reviewed the mammograms performed in our department between 1998 and 1995, selecting 16 patients (12 women and 4 men). Nine patients had benign breast lesions (adenomyoepithelioma, epidermal cyst, adenoid cystic carcinoma, myofibroblastoma, multiple hamartomas, intra cystic papillomas, lipoma, idiopathic granulomatous mastitis and fat necrosis) and 7 patients presented malignant breast diseases (malignant fibrous histiocytoma, intra cystic carcinoma, primary lymphoma of the breast, liposarcoma and metastasis). We present a review of the radiologic and pathologic findings in several uncommon breast diseases. (Author) 14 refs

  3. A study on heat transfer characteristics of spherical and fibrous alumina nanofluids

    Highlights: ► Spherical and fibrous alumina nanoparticles were prepared by pulsed wire evaporation and hydrolysis methods. ► Fibrous alumina nanofluid exhibited higher thermal conductivity enhancement than spherical one due to entangled structure of nanofibers with high aspect-ratio. ► Decreasing rate of viscosity with temperature for fibrous alumina nanofluid was much larger than that for spherical one. - Abstract: Ethylene glycol based nanofluids containing spherical/fibrous alumina nanoparticles were synthesized by pulsed wire evaporation and hydrolysis methods. The crystallographic and morphological properties of the prepared nanoparticles were analyzed by X-ray diffraction, nitrogen gas adsorption and transmission electron microscopy. The average diameter of spherical alumina nanoparticles was about 80 nm and the alumina nanofibers exhibited a high aspect ratio (length/width). The viscosity and thermal conductivity of the spherical/fibrous alumina nanofluids were experimentally measured in the temperature range from 25 to 80 °C. For the fibrous alumina nanofluid, the increase of temperature raised thermal conductivity but lowered viscosity. On the other hand, for the spherical alumina nanofluid, both thermal conductivity and viscosity were decreased with increasing temperature. In particular, the fibrous alumina nanofluid exhibited a higher enhancement of thermal conductivity than the spherical one due to the well-connected structure between entangled nanofibers with high aspect ratio.

  4. Fibrous capsule formation of the peritoneal catheter tip in ventriculoperitoneal shunt: Two case reports

    Tomoaki Kano

    2014-01-01

    Full Text Available Background: A fibrous capsule formation of a peritoneal catheter tip has not previously been researched as a complication of ventriculoperitoneal (VP shunts. Case Description: Two adult patients who had undergone a VP shunt for communicative hydrocephalus following subarachnoid hemorrhage caused by a ruptured aneurysm have been identified with malfunction of the VP shunt system by mild disturbance of consciousness and gait disturbance or loss of appetite. Hydrocephalus was diagnosed by computed tomography and the obstruction of the peritoneal catheter was revealed by shuntgraphy. Laparoscopy was performed and the peritoneal catheter tips were obstructed by fibrous white capsules that covered them. One was a thin membranous capsule like a stocking with two small endoluminal granulomas of the peritoneal catheter, and other one was a fibrous glossy white capsule like a sock. These fibrous capsules were excised by laparoscopy forceps without the conversion to a new peritoneal catheter. Following the procedure, the shunt functioned normally. The pathological diagnoses were peritoneum with foreign body reaction or hyalinization of membranous tissue surrounded by fibrous tissue. Conclusion: These fibrous capsules might be formed by the peritoneal reaction to cerebrospinal fluid as a foreign material. As such, a periodic medical check should be scheduled since a fibrous capsule of the peritoneal catheter tip might be formed again.

  5. Polyostotic fibrous dysplasia associated with intramuscular myxomas: Mazabraud's syndrome

    Mazabraud's syndrome, though uncommon, is reported increasingly frequently. It represents an entity readily recognisable radiologically on MR imaging. Awareness of the syndrome, particularly when the myxoma is solitary, can prevent misdiagnosis of intramuscular myxomas (especially when large) as malignant mesenchymal tumors containing myxoid tissue. We review the 34 cases previously reported in the literature and include a recent case from our center. (orig.)

  6. Improvement of hydrophilic properties of electrospun polyamide-imide fibrous mats by atmospheric-pressure plasma treatment

    Park, Soo-Jin; Yop Rhee, Kyong; Jin, Fan-Long

    2015-03-01

    Polyamide-imide (PAI) fibrous mats were fabricated through electrospinning and further treated with atmospheric-pressure plasma. The surface characteristics of the PAI fibrous mats were examined to determine the effect of plasma treatment on the hydrophilic properties. FT-IR, X-ray photoelectron spectroscopy, and contact-angle analysis indicated that the hydrophilicity of the PAI fibrous mats increased upon the introduction of hydrophilic groups by plasma treatment. The concentration of functional groups, including oxygen, and the surface roughness of the PAI fibrous mats increased with increasing treatment time. The optimum plasma treatment time for surface modification of the PAI fibrous mats under atmospheric pressure was 120 s.

  7. Case report 557: Solitary intramuscular myxoma in a patient with polyostotic fibrous dysplacia

    We report a case of solitary intramuscular myxoma in a patient with polyostotic fibrous dysplasia and pigmented macules. MR played an important role in the patient's pre-operative evaluation. It has been demonstrated in a review of the literature that a definite relationship exists between myxoma of soft tissues and fibrous dysplasia of the skeleton. Multiple myxomas in a patient with fibrous dysplasia are common and a relationship also exists between myxoma of the soft tissues and the McCune-Albright syndrome. (orig./GDG)

  8. A large infiltrating fibrous hamartoma of infancy in the abdominal wall with rare associated tuberous sclerosis

    Han, Hye-Jeong; Lim, Gye-Yeon [The Catholic University of Korea, Department of Radiology, St. Mary' s Hospital, Seoul (Korea); You, Chang-Young [The Catholic University of Korea, Department of Pathology, St. Mary' s Hospital, Seoul (Korea)

    2009-07-15

    Tuberous sclerosis is a complex autosomal-dominant neurocutaneous syndrome characterized by hamartomatous malformations of fibrous and connective tissues in various organs. Although various histologic types of soft-tissue masses can occur with tuberous sclerosis, we present a unique case of fibrous hamartoma of infancy presenting as large infiltrating cutaneous and subcutaneous masses in the abdominal wall in a 4-year-old boy with tuberous sclerosis. Although the co-occurrence of tuberous sclerosis and fibrous hamartoma of infancy is very rare, it should be considered in the differential diagnosis of subcutaneous soft-tissue masses found in children with tuberous sclerosis. (orig.)

  9. A large infiltrating fibrous hamartoma of infancy in the abdominal wall with rare associated tuberous sclerosis

    Tuberous sclerosis is a complex autosomal-dominant neurocutaneous syndrome characterized by hamartomatous malformations of fibrous and connective tissues in various organs. Although various histologic types of soft-tissue masses can occur with tuberous sclerosis, we present a unique case of fibrous hamartoma of infancy presenting as large infiltrating cutaneous and subcutaneous masses in the abdominal wall in a 4-year-old boy with tuberous sclerosis. Although the co-occurrence of tuberous sclerosis and fibrous hamartoma of infancy is very rare, it should be considered in the differential diagnosis of subcutaneous soft-tissue masses found in children with tuberous sclerosis. (orig.)

  10. Preparation and Properties of Friction Materials by Using Two Kinds of Fibrous Industrial Minerals

    SHEN Shang-yue; HU Shan; LI Zhen; ZHANG De; LIU Xin-hai; SONG Xu-bo

    2003-01-01

    The basic technology and properties of the brake blocks made of modified needle-like wollastonite and fibrous sepiolite were intensively researched.The impact strengthes and fixed velocity friction of the brake blocks prepared by different recipes were tested. The testing results show that it is feasible for needle-like wollastonite and fibrous sepiolite to take the place of asbestos as the reinforced materials of friction materials.The braking effect of the brake blocks is the best when the ratio of the needle-like wollastonite to the fibrous sepiolite was 1∶6.

  11. Second malignancy in relation to treatment modality of primary malignancy

    Second malignant tumors among long-term survivors are a sensitive indicator of successful oncologic treatment, particularly in this area of multimodal therapy. 11 patients of abdominopelvic primary malignancy were detected to have a second malignancy of different pathology, and at a different site. These patients were assessed regarding treatment modality of initial cancer and time gap between the first and second malignancy. Lack of proper cancer registries, illiteracy, and lack of resources lead to poor patient follow-up; therefore population based studies is not possible

  12. Epigenetics in the hematologic malignancies

    Fong, Chun Yew; Morison, Jessica; Dawson, Mark A.

    2014-01-01

    A wealth of genomic and epigenomic data has identified abnormal regulation of epigenetic processes as a prominent theme in hematologic malignancies. Recurrent somatic alterations in myeloid malignancies of key proteins involved in DNA methylation, post-translational histone modification and chromatin remodeling have highlighted the importance of epigenetic regulation of gene expression in the initiation and maintenance of various malignancies. The rational use of targeted epigenetic therapies...

  13. Mortal postpartum neuroleptic malignant syndrome

    Üstündağ, Mehmet; Orak, Murat; Güloğlu, Cahfer; Doğan, Halil; Uysal, Emin

    2006-01-01

    Neuroleptic malignant syndrome is a serious side effect caused by antipsychotic medications. Neuroleptic malignant syndrome is believed to be triggered by neuroleptic blockade of dopaminergic receptors located in the hypothalamus and basal ganglia. The incidence of neuroleptic malignant syndrome with conventional antipsychotic agents has been reported to vary from 0.02-2.44%. Manifestations of this syndrome include severe muscle rigidity and high temperature with any of the following symptoms...

  14. Ibrutinib for B cell malignancies

    Novero, Aileen; Ravella, Pavan M; Chen, Yamei; Dous, George; Liu, Delong

    2014-01-01

    Research over the role of Bruton’s agammaglobulinemia tyrosine kinase (BTK) in B-lymphocyte development, differentiation, signaling and survival has led to better understanding of the pathogenesis of B-cell malignancies. Down-regulation of BTK activity is an attractive novel strategy for treating patients with B-cell malignancies. Ibrutinib (PCI-32765), a potent inhibitor of BTK induces impressive responses in B-cell malignancies through irreversible bond with cysteine-481 in the active site ...

  15. In vitro cartilage culture: flow, transport and reaction in fibrous porous media

    AHMADI-SENICHAULT, Azita; Lasseux, Didier; LETELLIER, Samuel

    2007-01-01

    Flow and transport in fibrous media are encountered in a wide variety of domains ranging from biotechnology to filtration in chemical engineering. The context of this work is the in vitro cartilage cell culture on a fibrous biodegradable polymer scaffold placed in a bioreactor. A seeding process using a liquid containing cells (chondrocytes) initiates the culture and an imposed continuous flow through the scaffold allows both the transport of nutrients necessary for cell-growth and of metabol...

  16. Fibrous metaphyseal defects - determination of their origin and natural history using a radiomorphological study

    The radiomorphological appearance of fibrous metaphyseal defects (FMDs) is demonstrated by long-term follow-up studies. A characteristic radiomorphological course rather than a typical single appearance can be established. These findings correlate well with the duration of these tumor-like lesions; therefore, the radiological findings allow conclusions to be made about the age of a fibrous metaphyseal defect. In addition, the characteristic locations of FMDs will be explained in respect of theier origins at insertions of tendons and ligaments. (orig.)

  17. A fibrous hypercrosslinked sorbent prepared on PP-ST-DVB matrix via post-crosslinking reaction

    Feng Liu; Si Guo Yuan; Xiao Li Wang; A.P. Polikarpov; A.A. Shunkevich

    2007-01-01

    A fibrous sorbent possessing abundant micropore structure was firstly prepared via post-crosslinking reaction on the PP-ST-DVB original fiber. Its micromorphology and sorptive properties were investigated, and the results. Demonstrated that the novel fibrous hypercrosslinked sorbent has narrow pore-size distribution, small average porous radius (1.90 nm), high specific surface area (362.31 m2/g), and fine sorptive properties for small organic molecules.

  18. Aortic Periannular Abscess Invading into the Central Fibrous Body, Mitral Valve, and Tricuspid Valve

    Oh, Hyun Kong; Kim, Nan Yeol; Kang, Min-Woong; Kang, Shin Kwang; Yu, Jae Hyeon; Lim, Seung Pyung; Choi, Jae Sung; Na, Myung Hoon

    2014-01-01

    A 61-year-old man was diagnosed with aortic stenoinsufficiency with periannular abscess, which involved the aortic root of noncoronary sinus (NCS) that invaded down to the central fibrous body, whole membranous septum, mitral valve (MV), and tricuspid valve (TV). The open complete debridement was executed from the aortic annulus at NCS down to the central fibrous body and annulus of the MV and the TV, followed by the left ventricular outflow tract reconstruction with implantation of a mechani...

  19. Poliostotic fibrous dysplasia in the left maxilla sinus. Case of presentation.

    Félix Dueñas Ros

    2007-04-01

    Full Text Available We present a clinic case of poliostotic fibrous dysplasia in the left maxilla sinus extended to Pterigopaltinar cavity and sphenoid sinus in a 26 year old woman who suffer from facial deformation. Paranasal x ray images didn’t permit to make the differential diagnosis between tumor or inflammatory lesions at the beginning, CT scan showed hiperdensy lesions like a tumor that suggest fibrous dysplasia. The final diagnosis was obtained by biopsy of the lesions.

  20. Disease severity and functional factors associated with walking performance in polyostotic fibrous dysplasia

    Paul, Scott M.; Gabor, Lisa R.; Rudzinski, Scott; Giovanni, David; Boyce, Alison M.; Kelly, Marilyn R.N.; Collins, Michael T.

    2013-01-01

    The purpose of this study was to determine the association between measures of disease severity, impairment, and ambulation ability in persons with polyostotic fibrous dysplasia (PFD). A cross-sectional sample of 81 patients (ages 5–57) with polyostotic fibrous dysplasia was evaluated as part of an ongoing study. Subjects were scored on the Skeletal Disease Burden Score (SDBS), completed a 9-minute walk test (9MW), manual muscle testing (MMT), and measurements of range of motion (ROM). Correl...

  1. Improvement of propeller blades used for handling liquids containing fibrous solids

    Bernauer, Jan; Wittekindt, Widu; Stark, Mathias

    1987-03-01

    The entrapment of long fibrous solids on the leading edge of axial centrifugal pump impeller blades was studied. These materials may increase the power drawn from the pump to the extent that, for example, a flood control pumping station may have to be shut down. Experiments studied the parameters fostering the entrapment of fibrous solids. A propeller blade eliminating entrapment was designed. The effectiveness of the design is demonstrated by experiments and field application.

  2. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Mark J. Rigali; Kenneth L. Knittel; Mike L. Fulcher

    2002-03-01

    During this reporting period, work continued on development of formulations using the materials identified as contenders for the fibrous monolith wear resistant components. The FM structures fabricated were: diamond/WC-Co, B{sub 4}C/WC-Co, TiB{sub 2}/WC-Co, WC-Co/Co, WC-Co/WC-Co. Results of our consolidation densification studies on these systems lead to the down-selection of WC-Co/WC-Co, WC-Co/Co and diamond/WC-Co for further development for mining applications including drill bit inserts, roof bit inserts, radial tools conical tools and wear plates (WC-Co based system only) for earth moving equipment. Prototype component fabrication focused on the fabrication of WC-Co/WC-Co FM conical tools, diamond/WC-Co coated drill bit insert prototypes. Fabrication of WC-Co/WC-Co FM insert prototypes for a grader blade is also underway. ACR plans to initiate field-testing of the drill bit insert prototypes and the grader blade insert this summer (2002). The first WC-Co/WC-Co FM conical tool prototypes were sent to Kennametal for evaluation towards the end of the current reporting period.

  3. Sperm protein 17 is expressed in the sperm fibrous sheath

    Albani Elena

    2009-07-01

    Full Text Available Abstract Background Sperm protein 17 (Sp17 is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues. It was also recognized in two myeloma cell lines and in neoplastic cells from patients with multiple myeloma and ovarian carcinoma. These data all indicate that Sp17 is widely distributed in humans, expressed not only in germinal cells and in a variety of somatic tissues, but also in neoplastic cells of unrelated origin. Methods Sp17 expression was analyzed by immunocytochemistry and transmission electron microscopy on spermatozoa. Results Here, we demonstrate the ultrastructural localization of human Sp17 throughout the spermatozoa flagellar fibrous sheath, and its presence in spermatozoa during in vitro states from their ejaculation to the oocyte fertilization. Conclusion These findings suggest a possible role of Sp17 in regulating sperm maturation, capacitation, acrosomal reaction and interactions with the oocyte zona pellucida during the fertilization process. Further, the high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP-binding motif within this region, suggest that Sp17 might play a regulatory role in a protein kinase A-independent AKAP complex in both germinal and somatic cells.

  4. Nanoscale dynamics and aging of fibrous peptide-based gels

    Dudukovic, Nikola A., E-mail: dudukov1@illinois.edu [Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States); Zukoski, Charles F. [Department of Chemical and Biological Engineering, University at Buffalo, Buffalo, New York 14222 (United States)

    2014-10-28

    Solutions of the aromatic dipeptide derivative molecule fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) in dimethyl sulfoxide produce fibrous gels when mixed with water. We study the evolution of density fluctuations of this three-component system using X-ray photon correlation spectroscopy (XPCS) and compare these results to the macroscopic rheology of the gels and optical observations of the microstructure evolution. At the investigated scattering angles, the intensity autocorrelation functions do not follow behavior expected for simple diffusion of individual Fmoc-FF molecules localized within cages of nearest neighbors. Instead, the dynamics are associated with density fluctuations on length scales of ∼10–100 nm arising from disaggregation and reformation of fibers, leading to an increasingly uniform network. This process is correlated with the growth of the elastic modulus, which saturates at long times. Autocorrelation functions and relaxation times acquired from XPCS measurements are consistent with relaxation rates of structures at dynamic equilibrium. This study provides further support to the concept of exploring peptide-based gelators as valence-limited patchy particles capable of forming equilibrium gels.

  5. Applications of phase change polymers in fibrous substrates

    This paper reports on insolubilization of polyethylene glycols (Mn of 600-20,000) onto a variety of fibrous substrates by reaction with a methylolamide resin (DMDHEU or dimethyloldihydroxyethyleneurea) in the presence of acid catalysts produced modified materials that have several improved functional properties and that are useful for numerous applications. Crosslinking or insolubilization of the polyols occurs under mild cuing conditions (80-100 degrees C). The resultant properties of the modified substrate (essentially a flexible composite of fiber and crosslinked polyol in the matrix) are markedly dependent on the proper choice of curing conditions (time and temperature). Representative fiber types and blends that have been modified by this process include: cotton, polyester, polyamide, cotton blends, wool blends, aramids, glass, acrylic, polypropylene, elastomeric fibers and short fibers used to make paper. All types of fabric constructions have been used (woven, nonwoven, and knit). The most novel property is the thermal adaptability of the modified fabrics or substrates to a variety of climatic conditions. This adaptability is due to the high enthalpy of fusion (cooling effect in hot weather) and crystallization (liberation of heat in cold weather) of the crosslinked polyethylene glycols (insolubilized phase change materials or PCM's). The novel thermal effects are due to the hydrophilic nature of the crosslinked polyol as well as its reduced thermal conductivity. Thermal profiles of the modified materials have been characterized by differential scanning calorimetry, infrared thermography, and by limited wear trials with garments containing the polymeric PCM's. There are other enhanced functional properties of the modified fabrics

  6. Fibrous dysplasia of the clivus: A Case Report

    Lewis D

    2007-01-01

    Full Text Available Introduction:Fibrous dysplasia (FD of the clivus, first described by Lichtenstein in 1938, is a very rare developmental, non-hereditary disorder caused by abnormal proliferation and maturation of fibroblasts resulting in replacement of mature bone by weak and immature bone.Case reportA 26-year-old otherwise fit and healthy Caucasian female presented to the Emergency Department with headache for 3 days, recurrent and getting worse. Neurological examination was normal. Blood investigations were essentially normal. Head CT scan showed slightly expanded clivus with ground glass density. MRI revealed slight expansion with focal signal alteration within the clivus, being hypointense on T1W images and FLAIR images and showing slightly increased signal intensity on T2W image.While in hospital the patient’s symptoms resolved with conventional painkiller treatment. Based on the current evidence available we opted for a conservative treatment and regular follow-ups and up to the day of writing this report, about eight months later, the patient is still on the same management plan.

  7. Fibrous adsorbent for removal of aqueous aromatic hydrocarbons.

    Jung, Yong-Jun; Kiso, Yoshiaki; Oguchi, Tatsuo; Yamada, Toshiro; Takagi, Hiroo; Nishimura, Kazuyuki

    2007-01-01

    Bundles of a strongly hydrophobic fibrous material (p-phenylene-2,6-benzobisoxazole; PBO; Zylon) were employed as an adsorbent for the removal of aqueous aromatic compounds, because the PBO fibers are too rigid to be woven and did not entrap suspended solids. The removal performance for nine kinds of polyaromatic hydrocarbons (PAHs) and di-(2-ethylhexyl) phthalate (DEHP) was evaluated. PAHs and DEHP at initial concentrations of 50 microg L(-1) were removed at 72.5-99.9% and ca. 95%, respectively, although the removal efficiencies were affected by the phase ratio (fiber weight/solution volume). The logarithm of the partition coefficient (log K) for planar PAHs was linearly correlated with the logarithm of the n-octanol/water partition coefficient (log P), but nonplanar PAHs, such as cis-stilbene, p-terphenyl, and o-terphenyl, showed significantly lower adsorption performance. The adsorbed PAHs were not desorbed effectively with CH3CN, CH2Cl2, and toluene. On the other hand, DEHP was effectively desorbed with methanol. PMID:17585293

  8. Fast numerical upscaling of heat equation for fibrous materials

    Iliev, Oleg

    2010-08-01

    We are interested in numerical methods for computing the effective heat conductivities of fibrous insulation materials, such as glass or mineral wool, characterized by low solid volume fractions and high contrasts, i.e., high ratios between the thermal conductivities of the fibers and the surrounding air. We consider a fast numerical method for solving some auxiliary cell problems appearing in this upscaling procedure. The auxiliary problems are boundary value problems of the steady-state heat equation in a representative elementary volume occupied by fibers and air. We make a simplification by replacing these problems with appropriate boundary value problems in the domain occupied by the fibers only. Finally, the obtained problems are further simplified by taking advantage of the slender shape of the fibers and assuming that they form a network. A discretization on the graph defined by the fibers is presented and error estimates are provided. The resulting algorithm is discussed and the accuracy and the performance of the method are illusrated on a number of numerical experiments. © Springer-Verlag 2010.

  9. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Mark J. Rigali; Mike L. Fulcher; Kenneth L. Knittel

    2002-10-01

    During the reporting period, work continued on development of formulations using the materials down-selected from the initially identified contenders for the fibrous monolith wear resistant components. The FM systems studied were: WC-Co/WC-Co, WC-Co/Co, diamond/WC-Co, and Al{sub 2}O{sub 3}/Al{sub 2}O{sub 3}-TiCN. Extrudable formulations for the materials listed were developed during the first twelve months of this effort, and work during the reporting period was focused on the development of optimized binder removal processes. A two stage binder removal process was developed that resulted in prototype parts free of voids and other internal defects. In addition, changes in the binder removal atmosphere resulted in the apparent elimination of residual carbon, an important consideration when consolidating WC-Co containing systems. Using the improved binder removal processes, parts were consolidated by both sintering and hot pressing to >99% theoretical density. Samples of these materials were sent to Kyocera for mechanical evaluations. Fabrication of drill bit inserts was begun, and binder removal begun during the reporting period. A total of 24 green inserts were fabricated, and will be consolidated and delivered for field testing during the upcoming reporting period.

  10. Giant solitary fibrous tumor arising from greater omentum

    Liang Zong; Ping Chen; Guang-Yao Wang; Qun-Shan Zhu

    2012-01-01

    Extrathoracic solitary fibrous tumors (SFTs) have been described at almost every anatomic location of human body,but reports of SFT in the abdominal cavity are rare.We herein present a rare case of SFT originating from greater omentum.Computed tomography revealed a 15.8 cm x 21.0 cm solid mass located at superior aspect of stomach.Open laparotomy confirmed its mesenchymal origin.Microscopically,its tissue was composed of non-organized and spindle-shaped cells exhibiting atypical nuclei,which were divided up by branching vessel and collagen bundles.Immunohistochemical staining showed that this tumor was negative for CD117,CD99,CD68,cytokeratin,calretinin,desmin,epithelial membrane antigen,F8 and S-100,but positive for CD34,bcl-2,α-smooth muscle actin and vimentin.The patient presented no evidence of recurrence during follow-up.SFT arising from abdominal cavity can be diagnosed by histological findings and immunohistochemical markers,especially for CD34 and bcl-2 positive cases.

  11. Cellular forces and matrix assembly coordinate fibrous tissue repair.

    Sakar, Mahmut Selman; Eyckmans, Jeroen; Pieters, Roel; Eberli, Daniel; Nelson, Bradley J; Chen, Christopher S

    2016-01-01

    Planar in vitro models have been invaluable tools to identify the mechanical basis of wound closure. Although these models may recapitulate closure dynamics of epithelial cell sheets, they fail to capture how a wounded fibrous tissue rebuilds its 3D architecture. Here we develop a 3D biomimetic model for soft tissue repair and demonstrate that fibroblasts ensconced in a collagen matrix rapidly close microsurgically induced defects within 24 h. Traction force microscopy and time-lapse imaging reveal that closure of gaps begins with contractility-mediated whole-tissue deformations. Subsequently, tangentially migrating fibroblasts along the wound edge tow and assemble a progressively thickening fibronectin template inside the gap that provide the substrate for cells to complete closure. Unlike previously reported mechanisms based on lamellipodial protrusions and purse-string contraction, our data reveal a mode of stromal closure in which coordination of tissue-scale deformations, matrix assembly and cell migration act together to restore 3D tissue architecture. PMID:26980715

  12. Nanoscale dynamics and aging of fibrous peptide-based gels

    Solutions of the aromatic dipeptide derivative molecule fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) in dimethyl sulfoxide produce fibrous gels when mixed with water. We study the evolution of density fluctuations of this three-component system using X-ray photon correlation spectroscopy (XPCS) and compare these results to the macroscopic rheology of the gels and optical observations of the microstructure evolution. At the investigated scattering angles, the intensity autocorrelation functions do not follow behavior expected for simple diffusion of individual Fmoc-FF molecules localized within cages of nearest neighbors. Instead, the dynamics are associated with density fluctuations on length scales of ∼10–100 nm arising from disaggregation and reformation of fibers, leading to an increasingly uniform network. This process is correlated with the growth of the elastic modulus, which saturates at long times. Autocorrelation functions and relaxation times acquired from XPCS measurements are consistent with relaxation rates of structures at dynamic equilibrium. This study provides further support to the concept of exploring peptide-based gelators as valence-limited patchy particles capable of forming equilibrium gels

  13. Nanoscale dynamics and aging of fibrous peptide-based gels

    Dudukovic, Nikola A.; Zukoski, Charles F.

    2014-10-01

    Solutions of the aromatic dipeptide derivative molecule fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) in dimethyl sulfoxide produce fibrous gels when mixed with water. We study the evolution of density fluctuations of this three-component system using X-ray photon correlation spectroscopy (XPCS) and compare these results to the macroscopic rheology of the gels and optical observations of the microstructure evolution. At the investigated scattering angles, the intensity autocorrelation functions do not follow behavior expected for simple diffusion of individual Fmoc-FF molecules localized within cages of nearest neighbors. Instead, the dynamics are associated with density fluctuations on length scales of ˜10-100 nm arising from disaggregation and reformation of fibers, leading to an increasingly uniform network. This process is correlated with the growth of the elastic modulus, which saturates at long times. Autocorrelation functions and relaxation times acquired from XPCS measurements are consistent with relaxation rates of structures at dynamic equilibrium. This study provides further support to the concept of exploring peptide-based gelators as valence-limited patchy particles capable of forming equilibrium gels.

  14. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY; SEMIANNUAL

    During this reporting period, work continued on development of formulations using the materials identified as contenders for the fibrous monolith wear resistant components. The FM structures fabricated were: diamond/WC-Co, B(sub 4)C/WC-Co, TiB(sub 2)/WC-Co, WC-Co/Co, WC-Co/WC-Co. Results of our consolidation densification studies on these systems lead to the down-selection of WC-Co/WC-Co, WC-Co/Co and diamond/WC-Co for further development for mining applications including drill bit inserts, roof bit inserts, radial tools conical tools and wear plates (WC-Co based system only) for earth moving equipment. Prototype component fabrication focused on the fabrication of WC-Co/WC-Co FM conical tools, diamond/WC-Co coated drill bit insert prototypes. Fabrication of WC-Co/WC-Co FM insert prototypes for a grader blade is also underway. ACR plans to initiate field-testing of the drill bit insert prototypes and the grader blade insert this summer (2002). The first WC-Co/WC-Co FM conical tool prototypes were sent to Kennametal for evaluation towards the end of the current reporting period

  15. Lung scans and malignancy

    An experience of pulmonary isotope scanning carried out with mercury 197 labelled mercury chloride and acetate, cobalt 57-labelled bleomycin, and Cu67 and Cu64 labelled copper citrate was presented. The scans were carried out with various isotopes supplied by the French Atomic Energy Authority, and gave comparable results, which may be summarised as follows: increased uptake in more than 90% of cases of carcinoma, absent uptake in all cases of benign tumour, frequent increased uptake in acute or advanced inflammatory lesions, absence of uptake, very commonly, in tuberculoma and chronic lesions with scar formation. Radio-isotope scan using Cu67 labelled copper citrate permitted discrimination of malignant tumours (increased fixation which showed up best at the 24th hour) from inflammatory lesions (increased fixation which was reduced on the 24th hour). The positive or negative character of the fixation in a given lesions remains the same, whatever the isotope used in our experience

  16. Neuroleptic malignant syndrome

    Mariana Moscovich

    2011-10-01

    Full Text Available Neuroleptic malignant syndrome (NMS is a potentially fatal adverse event associated with the use of antipsychotics (AP. The objective of this study was to investigate the profile of cases of NMS and to compare our findings with those published in similar settings. A series of 18 consecutive patients with an established diagnosis of NMS was analyzed, gathering data on demography, symptoms and signs. Two thirds of all cases involved woman with a past medical history of psychiatric disorder receiving relatively high doses of AP. The signs and symptoms of NMS episodes were similar to those reported in other series and only one case had a fatal outcome, the remaining presenting complete recovery. As expected, more than two thirds of our cases were using classic AP (68%, however the clinical profile of these in comparison with those taking newer agent was similar. Newer AP also carry the potential for NMS.

  17. Fibrous proteins: At the crossroads of genetic engineering and biotechnological applications.

    Yigit, Sezin; Dinjaski, Nina; Kaplan, David L

    2016-05-01

    Fibrous proteins, such as silk, elastin and collagen are finding broad impact in biomaterial systems for a range of biomedical and industrial applications. Some of the key advantages of biosynthetic fibrous proteins compared to synthetic polymers include the tailorability of sequence, protein size, degradation pattern, and mechanical properties. Recombinant DNA production and precise control over genetic sequence of these proteins allows expansion and fine tuning of material properties to meet the needs for specific applications. We review current approaches in the design, cloning, and expression of fibrous proteins, with a focus on strategies utilized to meet the challenges of repetitive fibrous protein production. We discuss recent advances in understanding the fundamental basis of structure-function relationships and the designs that foster fibrous protein self-assembly towards predictable architectures and properties for a range of applications. We highlight the potential of functionalization through genetic engineering to design fibrous protein systems for biotechnological and biomedical applications. Biotechnol. Bioeng. 2016;113: 913-929. © 2015 Wiley Periodicals, Inc. PMID:26332660

  18. Oculocutaneous malignancies in xeroderma pigmentosum.

    Varghese R; Raghuveer C

    1997-01-01

    Xeroderma pigmentosum is a rare autosomal recessive genodermatosis characterized by markedly increased sensitivity to sunlight, and the early development of skin tumours. Four cases of XP with malignancy have been described with a brief review of the literature. The cases have been documented with a view to study the evolution of the disease process and the development of malignancy during the follow up period.

  19. Genetics Home Reference: malignant hyperthermia

    ... on PubMed GeneReview: Malignant Hyperthermia Susceptibility Litman RS, Rosenberg H. Malignant hyperthermia: update on susceptibility testing. JAMA. ... 27(10):977-89. Review. Citation on PubMed Rosenberg H, Davis M, James D, Pollock N, Stowell ...

  20. Malignant priapism: a case report.

    Ellanti, P

    2011-12-01

    Metastatic involvement of the penis is most commonly from a primary malignant genitourinary tumour. It is a rare phenomenon usually reflecting disseminated malignancy associated with a poor prognosis. Metastasis to the penis mimicking priapism is extremely rare, particularly in the absence of disseminated disease.

  1. Håndens maligne tumorer

    Knudsen, Britt Mejer; Rasmussen, Per Joen Svabo; Lausten, Gunnar Schwarz; Jensen, Nina Vendel; Nielsen, Niels Søe

    2011-01-01

    Malignant tumours of the hand are rare and are often misdiagnosed. A painful swelling of the hand or digits are often diagnosed with an infection, benign tumours such as ganglion cysts, or arthritis. Wounds that do not heal despite adequate treatment should be biopsied to rule out malignancy. A...

  2. Vibration damage testing of thermal barrier fibrous blanket insulation

    GA Technologies is engaged in a long-term, multiphase program to determine the vibration characteristics of thermal barrier components leading to qualification of assemblies for High Temperature Gas-Cooled Reactor (HTGR) service. The phase of primary emphasis described herein is the third in a series of acoustic tests and uses as background the more elemental tests preceding it. Two sizes of thermal barrier coverplates with one fibrous blanket insulation type were tested in an acoustic environment at sound pressure levels up to 160 dB. Three tests were conducted using sinusoidal and random noise for up to 200 h duration at room temperature. Frequent inspections were made to determine the progression of degradation using definition of stages from a prior test program. Initially the insulation surface adjacent to the metallic seal sheets (noise side) assumed a chafed or polished appearance. This was followed by flattening of the as-received pillowed surface. This stage was followed by a depression being formed in the vicinity of the free edge of the coverplate. Next, loose powder from within the blanket and from fiber erosion accumulated in the depression. Prior experience showed that the next stage of deterioration exhibited a consolidation of the powder to form a local crust. In this test series, this last stage generally failed to materialize. Instead, surface holes generated by solid ceramic particulates (commonly referred to as 'shot') constituted the stage following powdering. With the exception of some manufacturing-induced anomalies, the final stage, namely, gross fiber breakup, did not occur. It is this last stage that must be prevented for the thermal barrier to maintain its integrity. (orig./GL)

  3. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Mark J. Rigali; Mike L. Fulcher

    2003-03-25

    During the reporting period, work continued on development of formulations using the materials down-selected from the initially identified contenders for the fibrous monolith wear resistant components. In the previous reporting period, a two-stage binder removal process was developed that resulted in prototype parts free of voids and other internal defects. During the current reporting period, work was performed to characterize the two-stage binder removal process for WC-Co based FM material systems. Use of this process has resulted in the fabrication of defect free sintered WC-Co FM bodies, with minimal free carbon porosity and densities approaching 100% theoretical. With the elimination of free carbon porosity and other binder removal process related defects, development work focused on optimizing the densification and eliminating defects observed in WC-Co based FM consolidated by pressureless sintering. Shrinkage of the monolithic core and shell materials used in the WC-Co based FM system was measured, and differences in material shrinkage were identified as a potential cause of cell boundary cracking observed in sintered parts. Re-formulation of material blends for this system was begun, with the goal of eliminating mechanical stresses during sintering by matching the volumetric shrinkage of the core and shell materials. Thirty-three 7/8 inch drill bit inserts (WC-Co(6%)/WC-Co(16%) FM) were hot pressed during the reporting period. Six of these inserts were delivered for field-testing by Superior Rock Bit during the upcoming reporting period. In addition, Al{sub 2}O{sub 3}/Al{sub 2}O{sub 3}-TiCN FM cutting tool inserts were fabricated, and cutting tests performed.

  4. [Malignant peritoneal mesothelioma].

    Torrejón Reyes, Paul N; Frisancho, Oscar; Gómez, Aldo; Yábar, Alejandro

    2010-01-01

    The peritoneal mesothelioma is a rare pathology with unspecific symptoms reason to be a difficult diagnosis. We report a case of a 58 year old man with diabetes mellitus type 2, arterial hypertension and smoking; without precedent of asbestos exposure. The patient presented a one month history characterized by progressive increase of the abdominal volume and sensation of fullness; three weeks later they added breathlessness and hyporexia. The patient was in regular general condition; he was not presenting hepatic stigmas, edema or adenomegalies. The examination of thorax and cardiovascular it was normal. The abdomen distended by ascites, not painful, liver and spleen not examined. Laboratory: Hemoglobin 11,9 gr/dl, WBC 6840/mm3 Bands 1 %, lymphocytes 10 %, platelets 620000/mm3, PT 12 seconds, PTT 34 seconds, glucose 158 mg/dl, BUN 20,5 mg/ dl, creatinine 1,2 mg/dl, proteins 6,1 gr/dl, albumin 2,6 gr/dl. LDH 316 U/l, beta2microglobulin 2,2 mg/l (0.83-1.15 mg/l). HBV and HCV negative. Ca 19.9, CEA, AFP and PSA negative. Hemocultive negative. Ascitic fluid: ADA 20,3 U/l, serum-ascitic albumin gradient (SAAG) 1,1. Leukocytes 2237 cells/mm3, PMN 6 %, lymphocytes 90 %, mesothelial cells 4 %, proteins 4,6 gr/dl, albumin 2,34 gr/dl, glucose 44 mg/dl, LDH 1918 U/l. Gram and cultive: negatives. BAAR and cultive: negative . Cytology: mesothelial cells with changes of type reagent, Block cell for tumour cells: negative. Abdominal US: increased peritoneum and abundant ascitic fluid. Thoracic-abdominal CT: left side pleural effusion, severe ascites with thick epyplon. Upper GI endoscopy: moderate gastritis. Colonoscopy: two small sessile polyps in sigmoid colon. The finds of the laparoscopy were interpreted like carcinomatosis or peritoneal tuberculosis. The report of the peritoneal biopsy was informed as suggestive of undifferentiated carcinoma; the reappraisal with inmunohystochemic (calretinin +,cytokeratin +, vimentin +) indicated malignant peritoneal mesothelioma, type

  5. STRENGTH AND DEFORMABILITY OF STRUCTURAL ELEMENTS OF TRANSPORT FACILITIES ON THE BASIS OF FINE-GRAINED FIBROUS STEEL SLAG CONCRETE

    R. N. Chernousov

    2011-11-01

    Full Text Available Problem statement. Application of steel fibrous concrete in structures of transport facilities providesfor their reliable and durable operation, however, along with the indisputable advantages,steel fibrous concrete has significant drawback. Its application in transport construction is very expensive.The use of cast slag crushed stone screenings, along with fibers from waste products oflocal factories, as a filler of concrete matrix will significantly reduce the costs of production oftransport facility structures and their elements with the use of steel fibrous concrete.Results and conclusions. According to the results of experimental studies formulae for practical estimationof shrinkage deformations of concrete matrix of fibrous steel slag concrete are obtained. Theanalytical relationships for fibrous steel slag concrete are derived. These relationships involve ultimatecompression and tensile strength, increase in compression and bending strength with time, longtermcompression strength, low cycle tensile fatigue, wearability. Based on experimental studies theuse of fibrous steel slag concrete in structural elements of transport facilities is suggested.

  6. Gallium-67 scanning of malignant lymphomas

    The presence of a residual mass is a frequent and difficult problem in the treatment of Hodgkin's or non-Hodgkin's lymphoma: since it is of major importance to determine whether the lesion is a fibrous mass or a still progressing tumour requiring additional therapy. Gallium-67 scanning, performed in a series of 52 patients, provides an answer to this question since there is an excellent correlation between gallium uptake by the tumoral masses and their progressiveness. Magnetic resonance imaging was carried out in half of our patients: the finding of a low-intensity signal on T2-weighted sequences proved that the residual mass was fibrous, whereas a high-intensity signal on T2-weighted sequences did not distinguish between fibrous and tumour masses. The priceless information provided by the simple and non invasive method that is gallium scanning is extremely useful to evaluate the extension of lymphomas and to determine whether residual masses are tumoral or fibrous

  7. Compositional variation of fibrous callus and joint cartilage in different internal environments

    SUN Xiao-tang; HU Yun-yu; ZHAO Li; L(U) Rong; WANG Jun; BAI Jian-ping

    2006-01-01

    Objective: To evaluate the compositional variation of fibrous callus in the fracture site and the joint cavity and joint cartilage after being transplanted in the muscle pouch.Methods: Thirty 2-month-old New Zealand white rabbits (weighing 1-1.5 kg) were randomly divided into two groups: a callus transplantation group (Group A, n =15) and a cartilage transplantation group ( Group B, n =15). In Group A, closed radius fracture was made and the autologous fibrous callus was transplanted in the right knee joint cavity at 12 days postoperatively. In Group B, the right knee joint cartilage of the animals was transplanted in the autologous back muscle pouches under anesthesia. Then all the animals were killed by overdose anesthetic 3 weeks after transplantation. And the transplanted fibrous callus,the healed bones in the fracture sites and the transplanted joint cartilage were obtained for assessment of compositional variation.Results: Pure fibrous composition was found in the callus at the fracture sites in Group A at 12 days postoperatively. And for 11 out of the 15 animals, the fibrous callus was transformed into cartilaginous tissues after 3 weeks of transplantation, but the fibrous callus was absent in the other 4 animals. The fibrous calluses at the original site and the fracture locus were differentiated into bony tissues. Bony tissue transformation was found in the transplanted joint cartilages in the muscle pouch of all the animals in Group B.Conclusions: The fracture sites or joint cavity may facilitate callus differentiation in different ways: the former is helpful for osteogenesis while the latter for the development and maintenance of cartilages, and the muscle pouch is inclined to induce the osteogenic phenotype for cartilages.

  8. Childhood ovarian malignancy.

    Mahadik, Kalpana; Ghorpade, Kanchanmala

    2014-04-01

    Objective of this article is to appraise diagnostic aspects and treatment modalities in childhood ovarian tumor in background of available evidence. Literature search on Pubmed revealed various aspects of epidemiology, histopathological diagnosis, and treatment of pediatric ovarian tumor. 85 % of childhood tumors are germ cell tumors. The varied histopathological picture in germ cell tumors poses a diagnostic and therapeutic challenge. Immunohistochemistry and newer genetic markers like SALL4 and karyopherin-2 (KPNA2) have been helpful in differentiating ovarian yolk sac tumor from dysgerminoma, teratomas, and other pictures of hepatoid, endometrioid, clear cell carcinomatous, and adenocarcinomatous tissues with varied malignant potential. Before platinum therapy, these tumors were almost fatal in children. Fertility-conserving surgery with bleomycin, etoposide, and cisplatin has dramatically changed the survival rates in these patients. This modality gives cancer cure with healthy offspring to female patients with childhood ovarian tumor. Evidence also supports this protocol resulting in successful pregnancy rates and safety of cytotoxic drugs in children born to these patients. PMID:24757335

  9. Malignant renal tumors in children

    Justin Scott Lee

    2015-05-01

    Full Text Available Renal malignancies are common in children. While the majority of malignant renal masses are secondary to Wilms tumor, it can be challenging to distinguish from more aggressive renal masses. For suspicious renal lesions, it is crucial to ensure prompt diagnosis in order to select the appropriate surgical procedure and treatment. This review article will discuss the common differential diagnosis that can be encountered when evaluating a suspicious renal mass in the pediatric population. This includes clear cell sarcoma of the kidney, malignant rhabdoid tumor, renal medullary carcinoma and lymphoma. 

  10. The differentiation of malignant and benign musculoskeletal tumors by F-18 FDG PET/CT studies-determination of maxSUV by analysis of ROC curve

    Kong, Eun Jung; Cho, Ihn Ho; Chun, Kyung Ah; Won, Kyu Chang; Lee, Hyung Woo; Choi, Jun Heok; Shin, Duk Seop [Yeungnam University College of Medicine, Daegu (Korea, Republic of)

    2007-12-15

    We evaluated the standard uptake value (SUV) of F-18 FDG at PET/CT for differentiation of benign from malignant tumor in primary musculoskeletal tumors. Forty-six tumors (11 benign and 12 malignant soft tissue tumors, 9 benign and 14 malignant bone tumors) were examined with F-18 FDG PET/CT (Discovery ST, GE) prior to tissue diagnosis. The maxSUV(maximum value of SUV) were calculated and compared between benign and malignant lesions. The lesion analysis was based on the transverse whole body image. The maxSUV with cutoff of 4.1 was used in distinguishing benign from malignant soft tissue tumor and 3.05 was used in bone tumor by ROC curve. There was a statistically significant difference in maxSUV between benign (n = 11; maxSUV 3.4 {+-} 3.2) and malignant (n = 12; maxSUV 14.8 {+-} 12.2) lesion in soft tissue tumor ({rho} = 0.001). Between benign bone tumor (n = 9; maxSUV 5.4 {+-} 4.0) and malignant bone tumor (n = 14; maxSUV 7.3 {+-} 3.2), there was not a significant difference in maxSUV. The sensitivity and specificity for differentiating malignant from benign soft tissue tumor was 83% and 91%, respectively. There were four false positive malignant bone tumor cases to include fibrous dysplasia, Langerhans-cell histiocytosis (n = 2) and osteoid osteoma. Also, one false positive case of malignant soft tissue tumor was nodular fasciitis. The maxSUV was useful for differentiation of benign from malignant lesion in primary soft tissue tumors. In bone tumor, the low maxSUV correlated well with benign lesions but high maxSUV did not always mean malignancy.

  11. Preparation of poly(ethylene glycol/polylactide hybrid fibrous scaffolds for bone tissue engineering

    Ni P

    2011-11-01

    Full Text Available PeiYan Ni, ShaoZhi Fu, Min Fan, Gang Guo, Shuai Shi, JinRong Peng, Feng Luo, ZhiYong QianState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People's Republic of ChinaAbstract: Polylactide (PLA electrospun fibers have been reported as a scaffold for bone tissue engineering application, however, the great hydrophobicity limits its broad application. In this study, the hybrid amphiphilic poly(ethylene glycol (PEG/hydrophobic PLA fibrous scaffolds exhibited improved morphology with regular and continuous fibers compared to corresponding blank PLA fiber mats. The prepared PEG/PLA fibrous scaffolds favored mesenchymal stem cell (MSC attachment and proliferation by providing an interconnected porous extracellular environment. Meanwhile, MSCs can penetrate into the fibrous scaffold through the interstitial pores and integrate well with the surrounding fibers, which is very important for favorable application in tissue engineering. More importantly, the electrospun hybrid PEG/PLA fibrous scaffolds can enhance MSCs to differentiate into bone-associated cells by comprehensively evaluating the representative markers of the osteogenic procedure with messenger ribonucleic acid quantitation and protein analysis. MSCs on the PEG/PLA fibrous scaffolds presented better differentiation potential with higher messenger ribonucleic acid expression of the earliest osteogenic marker Cbfa-1 and mid-stage osteogenic marker Col I. The significantly higher alkaline phosphatase activity of the PEG/PLA fibrous scaffolds indicated that these can enhance the differentiation of MSCs into osteoblast-like cells. Furthermore, the higher messenger ribonucleic acid level of the late osteogenic differentiation markers OCN (osteocalcin and OPN (osteopontin, accompanied by the positive Alizarin red S staining, showed better maturation of osteogenic induction on the PEG/PLA fibrous scaffolds at the

  12. Backscatter factor and absorption ratio of fibrous zirconia media in the visible

    Fibrous thermal insulations are widely used to conserve energy in ambient to high temperature applications including buildings, solar collectors, heat exchangers, furnaces and thermal protection systems of reusable launch vehicles. It has long been recognised that zirconia has the lowest thermal conductivity of commercial refractories. The thermal conductivity of a zirconia fibrous medium is strongly dependent of its bulk density; high bulk densities of zirconia fibers provide the most effective insulation at high temperatures. Lee's theory for radiative transfer through fibrous media is used in this paper. The two-flux model is applied to determine the backward and forward parameters of a medium of zirconia fibers oriented in parallel planes. Theoretical calculations of the backscatter factor and absorption ratio of this medium are carried out in the visible spectrum for different size parameters of the fibers and for three different temperatures. Our results show that the backscatter factor of zirconia fibrous insulations is maximum, and therefore the heat transfer by the fibrous medium is the lowest, for a size parameter of 0.45 for all the temperatures studied. We also observed that the backscatter factor decreases with increasing temperature. (author)

  13. Adsorption kinetics and isotherms of zeolite coatings directly crystallized on fibrous plates for heat pump applications

    Zeolite A coatings were grown on porous fibrous metal plates by using the substrate heating synthesis method. The coatings prepared were characterized by X-ray diffraction (XRD) and laser microscopy. Kinetic measurements were performed to determine the rates of adsorption of these materials while their adsorption isotherms were obtained by thermogravimetry (TG). The overall adsorption kinetics varied with the different samples investigated. The zeolite A coating grown on a copper fibrous support generally exhibited superior overall adsorption kinetics compared to a zeolite X coating with close mass, prepared previously on a stainless steel flat plate. The coating thickness as well as the support properties affected the performances of the samples. The inclusion of an additional polymer layer exhibited adverse impact on the kinetics especially after relatively high normalized loadings. The adsorption isotherms obtained for the zeolite coatings on fibrous supports were quite typical for zeolite A while the addition of polymer changed the isotherm type. -- Highlights: • Thick zeolite A coatings were grown on fibrous metal plates. • Use of fibrous supports improved heat transfer quality. • Coating thickness influenced adsorption kinetics notably. • Inclusion of an additional polymer layer changed kinetics and isotherm type

  14. Hypertrophied anal papillae and fibrous anal polyps, should they be removed during anal fissure surgery?

    Pravin J. Gupta

    2004-01-01

    AIM: Hypertrophied anal papillae and fibrous anal polyps are not given due importance in the proctology practice.They are mostly ignored being considered as normal structures. The present study was aimed to demonstrate that hypertrophied anal papillae and fibrous anal polyps could cause symptoms to the patients and that they should be removed in treatment of patients with chronic fissure in anus.METHODS: Two groups of patients were studied. A hundred patients were studied in group A in which the associated fibrous polyp or papillae were removed by radio frequency surgical device after a lateral subcutaneous sphincterotomy for relieving the sphincter spasm. Another group of a hundred patients who also had papillae or fibrous polyps, were treated by lateral sphincterotomy alone. They were followed up for one year.RESULTS: Eighty-nine percent patients from group A expressed their satisfaction with the treatment in comparison to only 64% from group B who underwent sphincterotomy alone with the papillae or anal polyps left untreated. Group A patients showed a marked reduction with regard to pain and irritation during defecation (P= 0.0011),pricking or foreign body sensation in the anus (P = 0.0006)and pruritus or wetness around the anal verge (P = 0.0008).CONCLUSION: Hypertrophied anal papillae and fibrous anal polyps should be removed during treatment of chronic anal fissure. This would add to effectiveness and completeness of the procedure.

  15. Pancreatic Metastasis from a Solitary Fibrous Tumor of the Central Nervous System

    Takahiro Osuga

    2014-01-01

    Full Text Available Context Solitary fibrous tumor of the central nervous system is uncommon, with only around 200 reported cases. Further, extracranial metastasis is extremely rare, and only 5 cases of hematogenous metastases have been reported so far. To the best of our knowledge, there have been no reports of solitary fibrous tumor of the central nervous system metastasizing to the pancreas. Case report A 62-year-old woman was referred for evaluation of a pancreatic mass, which was strongly suspected to be a neuroendocrine tumor. However, the histological findings and immunohistochemical profile indicated the presence of a solitary fibrous tumor. Because the medical history revealed previous transcranial resection for intracranial meningioma 16 years ago, we conducted a pathological review of the brain specimen obtained by the first operation and found that it had the same histology and immunohistochemical profile as the current endoscopic ultrasound-guided fineneedle aspiration specimen. Consequently, the final diagnosis, on the basis of the brain specimen, was changed from meningioma to solitary fibrous tumor of the central nervous system, and the pancreatic mass was diagnosed as metastasis from solitary fibrous tumor of the central nervous system. The patient underwent middle pancreatectomy; the pancreatic specimen also had the same histology and immunohistochemical profile as the brain specimen. Conclusion Histological findings and immunohistochemical profile obtained by EUS-FNA are invaluable for the correct diagnosis to avoid excessive surgical procedures.

  16. Experimental investigation of sedimentation of LOCA - generated fibrous debris and sludge in BWR suppression pools

    Several tests were conducted in a 1:2.4 scale model of a Mark I suppression pool to investigate the behavior of fibrous insulation and sludge debris under LOCA conditions. NUKON trademark shreds, manually cut and tore up in a leaf shredder, and iron oxide particles were used to simulate fibrous and sludge debris, respectively. The suppression pool model included four downcomers fitted with pistons to simulate the steam-water oscillations during chugging expected during a LOCA. The study was conducted to provide debris settling velocity data for the models used in the BLOCKAGE computer code, developed to estimate the ECCS pump head loss due to clogging of the strainers with LOCA generated debris. The tests showed that the debris, both fibrous and particulate, remains fully mixed during chugging; they also showed that, during chugging, the fibrous debris underwent fragmentation into smaller sizes, including individual fibers. Measured concentrations showed that fibrous debris settled slower than the sludge, and that the settling behavior of each material is independent of the presence of the other material. Finally, these tests showed that the assumption of considering uniform debris concentration during strainer calculations is reasonable. The tests did not consider the effects of the operation of the ECCS on the transport of debris in the suppression pool

  17. Nonurological malignancies in children

    Lalit Parida

    2014-01-01

    Full Text Available Context: Nonurological malignancies in children include a wide variety of tumors. These tumors include primary tumors of the liver, thyroid, lung, gastrointestinal tract (GIT, and adrenals; soft tissue sarcomas (STSs like rhabdomyosarcoma (RMS and non-RMS; and finally extragonadal germ cell tumors (GCT. Aims: This article aims at describing the current thinking in the management of these childhood solid tumors. This is critical in view of the recent advances in the elucidation of the molecular, genetic, and biologic behavior of these tumors and how these factors are getting integrated not only in the staging but also in developing a risk-based approach towards the management of these tumors. Materials and Methods: Reference was made to recently published literature from the leading pediatric cancer centers of the world to make a sense of things of the most current thinking in this rapidly expanding field. This will provide surgeons and physicians taking care of these children with a working knowledge in this somewhat challenging field. Conclusions: Treatment results vary from center to center depending on access to resources and following different management protocols. Results have improved for these tumors with the advent of newer chemotherapeutic agents, novel delivery methods of radiation therapy (RT, and improvement in surgical technique. Due to the limited number of patients presenting with these tumors, national and international collaboration of data is critical for all and beneficial to individual treatment centers. This has resulted in better results in the past and will definitely result in still better results in the future.

  18. Bile duct malignancies.

    Tucek, S; Tomasek, J; Halámkova, J; Kiss, I; Andrasina, T; Hemmelová, B; Adámková-Krákorová, D; Vyzula, R

    2010-01-01

    Bile duct malignancies include intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC), gall bladder carcinoma (GC) and carcinoma of Vater's ampulla (ampulloma). Bile duct neoplasms are rare tumours with overall poor prognosis. The overall incidence affects up to 12.5 per 100,000 persons in the Czech Republic. The mortality rate has risen recently to 9.5 per 100,000 persons. The incidence and mortality have been remarkably stable over the past 3 decades. The survival rate of patients with these tumours is poor, usually not exceeding 12 months. The diagnostic process is complex, uneasy and usually late. Most cases are diagnosed when unresectable, and palliative treatment is the main approach of medical care for these tumours. The treatment remains very challenging. New approaches have not brought much improvement in this field. Standards of palliative care are lacking and quality of life assessments are surprisingly not common. From the scarce data it seems, however, that multimodal individually tailored treatment can prolong patients'survival and improve the health-related quality of life. The care in specialized centres offers methods of surgery, interventional radiology, clinical oncology and high quality supportive care. These methods are discussed in the article in greater detail. Improvements in this field can be sought in new diagnostic methods and new procedures in surgery and interventional radiology. Understanding the tumour biology on the molecular level could shift the strategy to a more successful one, resulting in more cured patients. Further improvements in palliative care can be sought by defining new targets and new drug development. The lack of patients with bile duct neoplasms has been the limiting factor for any improvements. A new design of larger randomized international multicentric clinical trials with prompt data sharing could help to overcome this major problem. Defining standards of palliative care is a necessity

  19. Treatment Option Overview (Malignant Mesothelioma)

    ... chest cavity and covers the lungs ) or the peritoneum (the thin layer of tissue that lines the ... to diagnose malignant mesothelioma in the chest or peritoneum: Physical exam and history : An exam of the ...

  20. Treatment Options for Malignant Mesothelioma

    ... chest cavity and covers the lungs ) or the peritoneum (the thin layer of tissue that lines the ... to diagnose malignant mesothelioma in the chest or peritoneum: Physical exam and history : An exam of the ...

  1. General Information about Malignant Mesothelioma

    ... chest cavity and covers the lungs ) or the peritoneum (the thin layer of tissue that lines the ... to diagnose malignant mesothelioma in the chest or peritoneum: Physical exam and history : An exam of the ...

  2. Drugs Approved for Malignant Mesothelioma

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for malignant mesothelioma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  3. Self-assembly studies of native and recombinant fibrous proteins

    Wilson, Donna Lucille

    The structure of silk proteins consists of alternating amorphous (glycine-rich) and ordered crystalline regions (poly(alanine) and poly(glycine-alanine) repeats), where the organized regions are typically beta-sheet assemblies. In collagen, the basic helical repeat (glycine-proline-hydroxyproline and variants on this repeat) drives hierarchical assembly. Three polypeptide chains form left-handed poly-proline II-like helices, these three chains then self-assemble to form a right-handed triple helix. The focus of this thesis is on these proteins and defined variations thereof to reveal features of fibrous protein self-assembly. The amino acid sequences of native silk and collagen and their respective assembly environments have been systematically manipulated. Spider silk protein, based on the consensus sequence of Nephila clavipes dragline-silk, was genetically engineered to include methionines flanking the beta-sheet forming polyalanine regions. These methionines could be selectively oxidized and reduced, altering the bulkiness and charge of a methionine-based sulfoxide group to control beta-sheet formation by steric hindrance. A second version of the sterical trigger included a recognition site for Protein Kinase A allowing for the selective phosphorylation of a serine. Patterning a monolayer of precursor "director" molecules on length scales ranging from nanometer- to micrometer-length scales simplifies the interpretation of supramolecular assembly. Utilizing the atomic force microscopy (AFM)-based technique of dip-pen nanolithography, thiolated collagen and a collagen-like peptide were patterned at 30--50 nm line widths on evaporated gold surfaces. These are the largest molecules thus far positively printed on a surface at such small-length scales. The method preserved the triple helical structure and biological activity of collagen and even fostered the formation of characteristic higher-levels of structural organization. Nanopatterns were also achieved for

  4. Optical reflectance in fibrous tissues and skeletal muscles

    Ranasinghesagara, Janaka C.

    We studied two biological tissues with optically anisotropic structures: high moisture soy protein extrudates and skeletal muscles. High moisture extrusion has been used to produce vegetable meat analogs that resemble real animal meat and have significant health benefits. Since visual and textural properties are key factors for consumer acceptance, assessing fiber formation in the extruded soy protein product is important for quality control purpose. A non-destructive method based on photon migration was developed to measure fiber formation in extruded soy proteins. The measured fiber formation index in intact samples showed good agreement with that obtained from image analysis on peeled samples. By implementing this new method in a fast laser scanning system, we have acquired two dimensional mappings of fiber formation and orientation in the entire sample in real time. In addition to fibrous structures, skeletal muscles have a unique periodic sarcomere structure which produces strong light diffractions. However, inconsistent experimental results have been reported in single fiber diffraction studies. By applying the three-dimensional coupled wave theory in a physical sarcomere model, we found that a variety of experimental observations can be explained if inhomogeneous muscle morphological profiles are considered. We also discovered that the sarcomere structure produced a unique optical reflectance pattern in whole muscle. None of the existing light propagation theories are able to describe this pattern. We developed a Monte Carlo model incorporating the sarcomere diffraction effect. The simulated results quantitatively resemble the unique patterns observed in experiments. We used a set of parameters to quantify the optical reflectance profiles produced by a point incident light in whole muscle. Two parameters, q and B, were obtained by numerically fitting the equi-intensity contours of the reflectance pattern. Two spatial gradients were calculated along the

  5. Microwave Ablation of Hepatic Malignancy

    Lubner, Meghan G.; Brace, Christopher L.; Ziemlewicz, Tim J.; Hinshaw, J. Louis; Lee, Fred. T.

    2013-01-01

    Microwave ablation is an extremely promising heat-based thermal ablation modality that has particular applicability in treating hepatic malignancies. Microwaves can generate very high temperatures in very short time periods, potentially leading to improved treatment efficiency and larger ablation zones. As the available technology continues to improve, microwave ablation is emerging as a valuable alternative to radiofrequency ablation in the treatment of hepatic malignancies. This article rev...

  6. Malignant schwannoma of the rectum

    Malignant schwannomas are rare. These malignomas are primary nerve sheath tumors that usually arise from a peripheral nerve. They appear most frequently in the lower extremities, including the hips and buttocks (34.8%), the upper extremities (23.4%), and in the trunk (17%). To the best of our knowledge, this is the first reported case of a malignant schwannoma of the rectum. We describe the rare disease with reference to the literature. (orig.)

  7. Malignant diseases as suicidal motives

    Bogdanović Ljiljana; Savić Slobodan; Basta-Jovanović Gordana

    2007-01-01

    Introduction Suicide is a conscious and intentional destruction of one’s own life, which occurs as a result of mutual influence of a person’s disposition and motives (facts inspiring the commitment of suicide). It is well known that various diseases, including malignancies, could be important and in some cases the only motive for committing suicide. Objective The purpose of the study was to analyze in detail suicides of persons whose only motive was an established malignant disease. Method Th...

  8. Solitary fibrous tumor of the male breast: a case report and review of the literature

    Sessa Fausto

    2008-02-01

    Full Text Available Abstract Extrapleural solitary fibrous tumors are very rare and occasionally they appear in extraserosal soft tissues or parenchymatous organs. In such cases the right preoperative diagnosis is often difficult and challenging, because both radiological and cytological examinations are not exhaustive. For these reasons, surgical excision is frequently the only way to reach the correct diagnosis and to achieve definitive treatment. A few cases of solitary fibrous tumors have been also described in the breast. Although rare, this lesion opens difficulties in preoperative diagnosis entering in differential diagnosis with other benign lesions as well as with breast cancer. In this article we describe a case of a solitary fibrous tumor of the breast in a 49-year-old man. Problems related to differential diagnosis and the possible pitfalls that can be encountered in the diagnostic iter of such rare tumor are discussed.

  9. A New Device for Characterisation of the Drainage Kinetics of Fibrous Suspensions Under Gravity

    Przybysz Piotr

    2014-12-01

    Full Text Available Gravity dewatering of fibrous suspension is one of basic technological operations in paper production process. Although there are numerous methods to determine dewatering of such suspensions, none of them can measure undisturbed flow of removed water. In the paper the idea and design of a new apparatus for the determination of drainage rate of fibrous suspensions is presented. The apparatus differs from other known devices by minimisation of filtrate flow resistance in the outlet part of the equipment. In the second part of the paper measurements of the drainage rate have been presented. The flow resistance of the fluid through the bottom wire screen in the device was determined. The calculated flow resistance will be used in the developed model of dynamic drainage of fibrous suspensions, which will be discussed in our following paper (Przybysz et al., 2014.

  10. Highly efficient fibrous dye-sensitized solar cells based on TiO2 nanotube arrays

    The structure of fibrous dye-sensitized solar cells, which were constructed by a TiO2 nanotube array on Ti wire as the photoanode twisted by a Pt wire counter electrode, has been first systematically investigated by accurately controlling the thread pitch distance of screwed Pt wire. It has been revealed that the thread pitch will strongly influence the photovoltaic performance and kinetic processes in fibrous solar cells. The effect of the length of the TiO2 nanotube on cell performance has also been discussed. After optimization, a relatively universal optimized thread pitch value of 1 mm for fibrous DSCs has been proved and the light-to-electricity conversion efficiency has been remarkably improved to 5.84%.

  11. Micromechanics approach to the magnetoelectric properties of laminate and fibrous piezoelectric/magnetostrictive composites

    We use a micromechanics approach to study the magnetoelectric (ME) properties of the piezoelectric/magnetostrictive composite with a 2-2 laminate structure and a 3-1 fibrous structure. It is found that the 3-1 composite has a higher ME coefficient than the 2-2 one, if the volume ratio of piezoelectric material is the same. The reason is that the 3-1 fibrous composite makes use of the longitudinal piezoelectric response and the piezoelectric voltage constant g33 is 2-3 times that of g31. Generally, a smaller volume ratio of the piezoelectric material will generate a higher ME response. The tensile stress at the piezoelectric/magnetostrictive interface of the 3-1 fibrous composite, however, could be high enough to induce plastic deformation or microcracks, which leads to a ME coefficient lower than the theoretically predicted one

  12. Role of Gd-DTPA in the differentiation of posttreatment changes recurrent musculoskeletal sarcomas

    This paper evaluates Gd-DTPA enhancement prospectively in 35 patients with treated musculoskeletal sarcomas (13 osteosarcomas, eight malignant fibrous histiocytomas, four synovial sarcomas). Thirteen patients with osteosarcoma received intraarterial chemotherapy 3 months to 2 years before surgery. Others received pre-and/or postoperative intravenous chemotherapy. Some also received external irradiation. Multiplanar images of the tumors were obtained on a 1.5-T Signa imager (General Electric) with a spin-echo technique. T1- and T2-weighted images were compared with enhanced T1-weighted images (intravenous Gd-DTPA, 0.1 mmol-kg)

  13. Lethal mass mimicking myxoma in the heart.

    Soo, Wern Miin; Pang, Yin Huei; Poh, Kian-Keong

    2014-10-01

    A 70-year-old man presented in advanced heart failure with jaundice. Transthoracic echocardiography revealed a 21 × 24-mm mass in the left atrium attached to the posterior mitral valve leaflet. Surgical excision was attempted, but the tumor had infiltrated the entire left atrial wall and was deemed too extensive to be resectable. Histology confirmed a high-grade pleomorphic sarcoma with malignant fibrous histiocytoma-like features. Liver biopsy revealed a high-grade liver sarcoma. PMID:24887828

  14. IL-4 gene expression in adventitial layer (fibrous layer) of hepatic ovine and bovine hydatid cysts.

    Dorosti, Zahra; Tolouei, Sepideh; Khanahmad, Hossein; Jafari, Rasool; Jafaee, Fereshteh; Sharafi, Seyedeh Marayam; Darani, Hossein Yousofi

    2016-09-01

    Cystic Echinococcosis is a parasitic disease with cosmopolitan distribution caused by the tape worm Echinococcus granulosus. Fibrous layer is developed around the cyst as a host immune response reaction. The aim of this study was to evaluate the rate of IL-4 gene expression in fibrous layer of bovine and ovine hepatic hydatid cysts using quantitative technique of Real-Time PCR. In this descriptive study the samples of hydatid cyst fibrous layer were taken from 6 bovine and 6 ovine hepatic hydatid cysts. Samples of normal liver tissue close to the cyst were also taken as controls. Total RNA from each sample was extracted and then converted to cDNA. Afterward, the rate of IL-4 gene expression for each sample was evaluated using real-time PCR technique. Data were analyzed by REST software (version 2.0.13, 2009). In sheep the rate of IL-4 gene expression in the fibrous layer of hepatic hydatid cysts was 1.98 times more than the rate of IL4 gene expression in control samples, but the difference was not significant (P = 0.561). In cattle the rate of IL-4 gene expression in the fibrous layer of hepatic hydatid cysts was 9.84 times more than that of control samples which was statistically significant (P < 0.001). With high rate of IL4 expression especially in fibrous layer of bovine hydatid cyst, it can be concluded that this interleukin may play an important role in host parasite relationship. PMID:27605798

  15. Water-stable three-dimensional ultrafine fibrous scaffolds from keratin for cartilage tissue engineering.

    Xu, Helan; Cai, Shaobo; Xu, Lan; Yang, Yiqi

    2014-07-22

    Intrinsically water-stable scaffolds composed of ultrafine keratin fibers oriented randomly and evenly in three dimensions were electrospun for cartilage tissue engineering. Keratin has been recognized as a biomaterial that could substantially support the growth and development of multiple cell lines. Besides, three-dimensional (3D) ultrafine fibrous structures were preferred in tissue engineering due to their structural similarity to native extracellular matrices in soft tissues. Recently, we have developed a nontraditional approach to developing 3D fibrous scaffolds from alcohol-soluble corn protein, zein, and verified their structural advantages in tissue engineering. However, keratin with highly cross-linked molecular structures could not be readily dissolved in common solvents for fiber spinning, which required the remarkable drawability of solution. So far, 3D fibrous scaffolds from pure keratin for biomedical applications have not been reported. In this research, the highly cross-linked keratin from chicken feathers was de-cross-linked and disentangled into linear and aligned molecules with preserved molecular weights, forming highly stretchable spinning dope. The solution was readily electrospun into scaffolds with ultrafine keratin fibers oriented randomly in three dimensions. Due to the highly cross-linked molecular structures, keratin scaffolds showed intrinsic water stability. Adipose-derived mesenchymal stem cells could penetrate much deeper, proliferate, and chondrogenically differentiate remarkably better on the 3D keratin scaffolds than on 2D PLA fibrous scaffolds, 3D soy protein fibrous scaffolds, or 3D commercial nonfibrous scaffolds. In summary, the electrospun 3D ultrafine fibrous scaffolds from keratin could be promising candidates for cartilage tissue engineering. PMID:25010870

  16. Nitridated fibrous silica (KCC-1) as a sustainable solid base nanocatalyst

    Bouhrara, Mohamed

    2013-09-03

    We observed that support morphology has dramatic effects on the performance of nitridated silica as a base. By simply replacing conventional silica supports (such as SBA-15 and MCM-41) with fibrous nanosilica (KCC-1), we observed multifold enhancement in the catalytic activity of the nitridated solid base for Knoevenagel condensations and transesterification reactions. This enhancement of the activity can be explained by amine accessibility, which is excellent in KCC-1 due to its open and flexible fibrous structure, that facilitates penetration and interaction with basic amine sites. © 2013 American Chemical Society.

  17. Calcifying fibrous tumor of the small intestine associated with Castleman-like lymphadenopathy.

    Valladolid, Genaro; Weisenberg, Elliot; Sundaresan, Ramamoorthy; Maker, Ajay V

    2014-06-01

    Calcifying fibrous tumor is a rare mesenchymal tumor that most commonly presents in younger individuals. We report the case of a 25-year-old woman that presented with severe abdominal pain and a small bowel mass at the site of an ileocolic intussusception with associated mesenteric lymphadenopathy. Surgical resection was performed, and pathologic analysis revealed that the mass was a calcifying fibrous tumor associated with Castleman-like adenopathy. This case intends to support a possible association between these two entities. PMID:24452381

  18. Primary Solitary Fibrous Tumor of the Thyroid - Report of a Case and Review of the Literature

    Zhigang Song, Chunkai Yu, Xin Song, Lixin Wei, Aijun Liu

    2011-01-01

    Full Text Available Solitary fibrous tumor (SFT is a rare spindle-cell neoplasm, especially in the thyroid. We report a case of primary solitary fibrous tumor of the thyroid gland in a 37 year-old Chinese man. The tumor was characterized by bland-looking spindle cells admixed with thin and thick collagen fibers. On immunohistochemistry study indicated that tumor cells were diffusely positive for CD34, Bcl-2 and CD99, and negative for Desmin, NSE, SMA, S-100, and CD68. The patient remains well 16 months after excision. The morphologic and immunohistochemical features of the thyroid SFTs are similar to their reported counterparts in other anatomic sites.

  19. An Investigation of the Radiative Heat Transfer through Nonwoven Fibrous Materials

    Imad Qashou; Hooman Vahedi Tafreshi; Behnam Pourdeyhimi

    2009-01-01

    In this study, the surface-to-surface radiation model of the Fluent CFD code is used to investigate the response of a fibrous material to the radiative heat transfer. The unsteady state heat transfer equation is solved for the temperature and heat flux in and around the fibers that constitute a nonwoven fibrous material. For a fixed fiber diameter, it was shown that the higher the fabric’s Solid Volume Fraction (SVF), the slower is the material’s average temperature rise. Our simulation resul...

  20. Nanoscale Piezoelectric Properties of Self-Assembled Fmoc-FF Peptide Fibrous Networks.

    Ryan, Kate; Beirne, Jason; Redmond, Gareth; Kilpatrick, Jason I; Guyonnet, Jill; Buchete, Nicolae-Viorel; Kholkin, Andrei L; Rodriguez, Brian J

    2015-06-17

    Fibrous peptide networks, such as the structural framework of self-assembled fluorenylmethyloxycarbonyl diphenylalanine (Fmoc-FF) nanofibrils, have mechanical properties that could successfully mimic natural tissues, making them promising materials for tissue engineering scaffolds. These nanomaterials have been determined to exhibit shear piezoelectricity using piezoresponse force microscopy, as previously reported for FF nanotubes. Structural analyses of Fmoc-FF nanofibrils suggest that the observed piezoelectric response may result from the noncentrosymmetric nature of an underlying β-sheet topology. The observed piezoelectricity of Fmoc-FF fibrous networks is advantageous for a range of biomedical applications where electrical or mechanical stimuli are required. PMID:25994251

  1. Design of multi-layered porous fibrous metals for optimal sound absorption in the low frequency range

    Wenjiong Chen

    2016-01-01

    Full Text Available We present a design method for calculating and optimizing sound absorption coefficient of multi-layered porous fibrous metals (PFM in the low frequency range. PFM is simplified as an equivalent idealized sheet with all metallic fibers aligned in one direction and distributed in periodic hexagonal patterns. We use a phenomenological model in the literature to investigate the effects of pore geometrical parameters (fiber diameter and gap on sound absorption performance. The sound absorption coefficient of multi-layered PFMs is calculated using impedance translation theorem. To demonstrate the validity of the present model, we compare the predicted results with the experimental data. With the average sound absorption (low frequency range as the objective function and the fiber gaps as the design variables, an optimization method for multi-layered fibrous metals is proposed. A new fibrous layout with given porosity of multi-layered fibrous metals is suggested to achieve optimal low frequency sound absorption. The sound absorption coefficient of the optimal multi-layered fibrous metal is higher than the single-layered fibrous metal, and a significant effect of the fibrous material on sound absorption is found due to the surface porosity of the multi-layered fibrous.

  2. Fibrous Support Stabilizes Nitrification Performance of a Membrane-Aerated Biofilm: The Effect of Liquid Flow Perturbation

    Terada, Akihiko; Ito, J; Matsumoto, S;

    2009-01-01

    Nitrification stability and biofilm robustness were examined by comparing a fibrous support membrane-aerated biofilm reactor (FS-MABR), where a woven fibrous support was surrounded on a silicone tube, with an MABR. The overall mass transfer coefficient of oxygen for the FS-MABR, assuming no...

  3. Antibacterial and anti-adhesion effects of the silver nanoparticles-loaded poly(L-lactide) fibrous membrane

    The complications of tendon injury are frequently compromised by peritendinous adhesions and tendon sheath infection. Physical barriers for anti-adhesion may increase the incidence of postoperative infection. This study was designed to evaluate the potential of silver nanoparticles (AgNPs)-loaded poly(L-lactide) (PLLA) electrospun fibrous membranes to prevent adhesion formation and infection. Results of an in vitro drug release study showed that a burst release was followed by sustained release from electrospun fibrous membranes with a high initial silver content. Fewer fibroblasts adhered to and proliferated on the AgNP-loaded PLLA electrospun fibrous membranes compared with pure PLLA electrospun fibrous membrane. In the antibacterial test, the AgNP-loaded PLLA electrospun fibrous membranes can prevent the adhesion of Gram-positive Staphylococcus aureus and Staphylococcus epidermidis and Gram-negative Pseudomonas aeruginosa. Taken together, these results demonstrate that AgNP-loaded PLLA electrospun fibrous membranes have the convenient practical medical potential of reduction of infection and adhesion formation after tendon injury. - Highlights: ► Silver nanoparticles are directly electrospun into PLLA fibrous membrane. ► Long-lasting release of Ag + ions is achieved. ► Cytotoxicity of silver ions benefits the anti-proliferation of physical barriers. ► Broad anti-microbial effect of drug-loaded fibrous membrane is revealed. ► Antibacterial and anti-adhesion effects of the physical barriers are combined

  4. Cutaneous malignant lymphomas: update 2006.

    Burg, Günter; Kempf, Werner; Cozzio, Antonio; Döbbeling, Udo; Feit, Josef; Golling, Philippa; Michaelis, Sonja; Schärer, Leo; Nestle, Frank; Dummer, Reinhard

    2006-11-01

    Cutaneous lymphomas represent a unique group of lymphomas and are the second most frequent extranodal lymphomas. As with other neoplasias, the pathogenesis is based mainly on a stepwise accumulation of mutations of suppressor genes and oncogenes caused by genetic, environmental or infectious factors. The diagnostic work-up includes clinical, histological, imaging and hematological investigations and in many cases immunohistochemical and molecular biological analyses. The current WHO/EORTC classification of cutaneous lymphomas differentiates "mature T-cell and NK-cell lymphomas", "mature B-cell lymphomas" and "immature hematopoietic malignancies", their variants and subgroups. It is compatible with the WHO classification for neoplasias of the hematopoietic and lymphoid tissue and respects the organ-specific peculiarities of primary cutaneous lymphomas. The assignment of the various types of cutaneous lymphomas into prognostic categories (pre-lymphomatous "abortive" disorders; definite malignant lymphomas of low-grade malignancy; definite malignant lymphomas of high-grade malignancy) provides essential information on the biological behavior and allows an appropriate planning of the therapeutic strategy, which may be topical or systemic and aggressive or non-aggressive. Besides the classical options for therapy, there are new and "experimental" strategies, the efficacy of which has to be studied in clinical trials. PMID:17081267

  5. Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics.

    Schaefer, Inga-Marie; Fletcher, Christopher Dm; Hornick, Jason L

    2016-01-01

    The diagnosis of malignant peripheral nerve sheath tumor is challenging, particularly in the sporadic setting. Inactivation of the polycomb repressive complex 2 (PRC2), resulting from inactivating mutations of its constituents SUZ12 or EED1, has recently been identified in 70-90% of malignant peripheral nerve sheath tumors. Homozygous PRC2 inactivation results in loss of histone H3K27 trimethylation (H3K27me3). PRC2 inactivation promotes tumor progression and may render patients sensitive to epigenetic-based targeted therapies. H3K27me3 loss has not yet been validated as a diagnostic marker. We evaluated immunohistochemistry for H3K27me3 in 100 malignant peripheral nerve sheath tumors (70 sporadic, 10 neurofibromatosis type 1-associated, 10 radiation-associated, 10 epithelioid) and 200 other spindle cell neoplasms representing potential mimics (20 each monophasic synovial sarcoma, leiomyosarcoma, dedifferentiated liposarcoma, malignant solitary fibrous tumor, low-grade fibromyxoid sarcoma, cellular schwannoma, spindle cell melanoma, unclassified postradiation sarcoma; 10 each atypical neurofibroma, spindle cell rhabdomyosarcoma, gastrointestinal stromal tumor, fibrosarcomatous dermatofibrosarcoma protuberans). In total, 51 (51%) malignant peripheral nerve sheath tumors, including 34 (49%) sporadic, 7 (70%) neurofibromatosis type 1-associated, and 10 (100%) radiation-associated, but no epithelioid malignant peripheral nerve sheath tumors, were negative for H3K27me3. An additional 6 (6%) tumors showed heterogeneous H3K27me3 expression. Among the 90 sporadic, neurofibromatosis type 1-associated, and radiation-associated malignant peripheral nerve sheath tumors, complete H3K27me3 loss was observed in 29% of low-grade, 59% of intermediate-grade, and 83% of high-grade tumors (low vs intermediate/high grade, P=0.0003). Among other tumor types, 4 (20%) unclassified postradiation sarcomas were negative for H3K27me3, whereas all other neoplasms were positive. Loss of H3K27me

  6. Surgically cured hypoglycemia secondary to pleural solitary fibrous tumour: case report and update review on the Doege-Potter syndrome

    Kalebi Ahmed Y

    2009-08-01

    Full Text Available Abstract The association of paraneoplastic hypoglycemia [Doege-Potter syndrome] and finger clubbing [Pierre-Marie-Bamberg syndrome] with pleural solitary fibrous tumour is rare. We present a previously unpublished but typical example of this rare occurrence together with a detailed updated literature review of previously published cases of pleural SFT discussing the histopathology of SFT; pathophysiology of the hypoglycemia and finger clubbing; treatment and outcome of pleural SFT. The patient, a 57-year-old African male was admitted at our hospital with recurrent episodes of hypoglycemia. He was found to have digital clubbing and decreased breath sounds in the right lower chest but no other significant clinical findings. His insulin level measured during an episode of hypoglycemia was undetectable. Chest radiograph and CT-scan revealed a lobulated mass in the right chest which was diagnosed to be SFT on histology. Surgical excision of the mass resulted in cure of the hypoglycemic episodes and rapid regression of the clubbing. Less than 65 cases of pleural SFT manifesting with hypoglycemia with or without finger-clubbing have been published in the English literature. The mean diameter of these tumours manifesting with hypoglycemia is 20 cm, 54% being benign while 42% were malignant. They predominantly present in the 6th-8th decade, average age of 64 years and a slight male preponderance at 58%. Complete surgical resection remains the most important predictor of clinical outcome in terms of recurrence and metastases, while providing instant cure for the hypoglycemia and rapid resolution of the finger clubbing.

  7. METASTATIC MALIGNANT MELANOMA: CASE REPORT

    Satish

    2015-06-01

    Full Text Available A 32 year s old man presented with well - defined lesion on the left sole 8 months back. Biopsy and FNAC from the lesion confirmed malignant melanoma left foot & the patient was advised excision. After 4 months patient gave h/o swelling on the medial aspect of the thigh. The patient was diagnosed to have fulminant metastatic malignant melanoma of the left foot with metastasis to femoral lymph node. This case report re - emphasizes the importance of the combined approach to ascertain diagnose early KEYWORDS : Melanoma .

  8. Stenting in Malignant Biliary Obstruction.

    Almadi, Majid A; Barkun, Jeffrey S; Barkun, Alan N

    2015-10-01

    Decompression of the biliary system in patients with malignant biliary obstruction has been widely accepted and implemented as part of the care. Despite a wealth of literature, there remains a significant amount of uncertainty as to which approach would be most appropriate in different clinical settings. This review covers stenting of the biliary system in cases of resectable or palliative malignant biliary obstruction, potential candidates for biliary drainage, technical aspects of the procedure, as well as management of biliary stent dysfunction. Furthermore, periprocedural considerations including proper mapping of the location of obstruction and the use of antibiotics are addressed. PMID:26431598

  9. Malignant diseases as suicidal motives

    Bogdanović Ljiljana

    2007-01-01

    Full Text Available Introduction Suicide is a conscious and intentional destruction of one’s own life, which occurs as a result of mutual influence of a person’s disposition and motives (facts inspiring the commitment of suicide. It is well known that various diseases, including malignancies, could be important and in some cases the only motive for committing suicide. Objective The purpose of the study was to analyze in detail suicides of persons whose only motive was an established malignant disease. Method The analysis was performed using the autopsy material of the Institute of Forensic Medicine, School of Medicine, University of Belgrade, during the period from 1990 to 2004. The reports on performed medico-legal autopsies were used, as well as history data obtained from the family members of suicidal persons, investigation reports and the available medical documents. Results In 1931 cases there was established suicidal nature of a violent death. Neoplasms were the suicidal motive in 37 persons (1.9%. The basic characteristics of the analyzed sample were predominance of males (26:11, ratio 2.4:1, the age of over 70 years and the highest incidence of malignant lung and breast tumors. Almost all cases were the persons who underwent treatment for malignant neoplasms over a longer period of time. During 19 autopsies (51.3% out of 37, a progressive phase of malignancy was established, i.e. metastases. The data on prior oral announcement of suicide intention were obtained for 70.3% (26 cases, and on previous suicidal attempts only for 13.5% (5 cases. In the majority of cases (78.4% the place of committed suicide was the person’s home. In 16 cases (43.2% the suicide was committed with a firearm. Hanging as a manner of destroying one’s own life was chosen by 12 persons (32.4%, while other ways were less frequently used. Conclusion Although malignancies were not present with high incidence as a suicidal motive in our analyzed sample, such cases require particular

  10. Primary supratentorial intracerebral malignant paraganglioma

    Ahmed A Al Jishi

    2015-06-01

    Full Text Available Paragangliomas are extra-adrenal neuroendocrine tumors that derive from neural crest. In general, they are benign tumors but few cases had shown a tendency to metastasize. Malignant forms have been reported previously with intracranial metastasis from duodenal origin, but primary intracranial origin represents a rare and unusual location for such tumors. Here, we report a rare case of a 48-year-old lady who presented with symptomatic right-sided insular mass with negative metastatic work up. A complete surgical resection had been done with an unexpected diagnosis of primary gangliocytic paraganglioma with malignant features.

  11. The Modified Fibrous Material on the Basis of Polyethyleneterephthalate and Metal / Carbon Nanostructures

    Yu.M. Vasilchenko

    2014-07-01

    Full Text Available Results of theoretical justification and experimental receiving a fibrous material on the basis of the polyethyleneterephthalate, modified metal/carbon nanostructuresare, presented in article. Possibility of receiving the polymeric fibers possessing the increased durability and sorption ability in comparison with not modified fibers is established.

  12. Cell alignment induced by anisotropic electrospun fibrous scaffolds alone has limited effect on cardiomyocyte maturation.

    Han, Jingjia; Wu, Qingling; Xia, Younan; Wagner, Mary B; Xu, Chunhui

    2016-05-01

    Enhancing the maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) will facilitate their applications in disease modeling and drug discovery. Previous studies suggest that cell alignment could enhance hPSC-CM maturation; however, the robustness of this approach has not been well investigated. To this end, we examined if the anisotropic orientation of hPSC-CMs imposed by the underlying aligned fibers within a 3D microenvironment could improve the maturation of hPSC-CMs. Enriched hPSC-CMs were cultured for two weeks on Matrigel-coated anisotropic (aligned) and isotropic (random) polycaprolactone (PCL) fibrous scaffolds, as well as tissue culture polystyrenes (TCPs) as a control. As expected, hPSC-CMs grown on the two types of fibrous scaffolds exhibited anisotropic and isotropic orientations, respectively. Similar to cells on TCPs, hPSC-CMs cultured on these scaffolds expressed CM-associated proteins and were pharmacologically responsive to adrenergic receptor agonists, a muscarinic agonist, and a gap junction uncoupler in a dose-dependent manner. Although hPSC-CMs grown on anisotropic fibrous scaffolds displayed the highest expression of genes encoding a number of sarcomere proteins, calcium handling proteins and ion channels, their calcium transient kinetics were slower than cells grown on TCPs. These results suggest that electrospun anisotropic fibrous scaffolds, as a single method, have limited effect on improving the maturation of hPSC-CMs. PMID:27131761

  13. Three dimensional web-like fibrous CuInS{sub 2} film

    Yoon, Hyun [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of); Kim, Min-woo [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of); Green School, Korea University, Seoul, 136-713 (Korea, Republic of); Kim, Hayong [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of); Al-Deyab, Salem S. [Petrochemicals Research Chair, Dept. of Chem., King Saud University, Riyadh 11451 (Saudi Arabia); James, Scott C. [Depts of Geology and Mechanical Engineering, Baylor University, Waco TX 76798-2534 (United States); Ahn, SeJin, E-mail: swisstel@kier.re.kr [Photovoltaic Laboratory, Korea Institute of Energy Research, 71-2 Jangdong, YuseongGu, DaeJeon 305-543 (Korea, Republic of); Yoon, Sam S., E-mail: skyoon@korea.ac.kr [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of)

    2015-10-01

    Graphical abstract: - Highlights: • Electrospun nanofibers were used to construct a 3D CuInS{sub 2} solar cell with enhanced surface area. • SEM images showed the 3D web-like, fibrous structure of the film. • The surface area had nearly doubled after incorporating the 3D nanostructure. - Abstract: To ensure effective collection of photo-generated minority electrons in a CuInS{sub 2} thin film solar cell, a three-dimensional nanostructure was constructed by electrospinning a copper-indium solution precursor onto a molybdenum substrate. The electrospun nanofibers adhered onto the underlying layers before undergoing sulfurization at 500 °C to produce a three-dimensional web-like fibrous CuInS{sub 2} film. This fibrous film was characterized by scanning electron microscopy, X-ray diffraction, and Auger electron spectroscopy, thereby characterizing the 3D fibrous nanostructure of the CuInS{sub 2} film. This 3D structure could lead to next-generation solar cells optimized for maximal charge separation to enhance photovoltaic efficiency of solution-processed thin film solar cells.

  14. Three dimensional web-like fibrous CuInS2 film

    Graphical abstract: - Highlights: • Electrospun nanofibers were used to construct a 3D CuInS2 solar cell with enhanced surface area. • SEM images showed the 3D web-like, fibrous structure of the film. • The surface area had nearly doubled after incorporating the 3D nanostructure. - Abstract: To ensure effective collection of photo-generated minority electrons in a CuInS2 thin film solar cell, a three-dimensional nanostructure was constructed by electrospinning a copper-indium solution precursor onto a molybdenum substrate. The electrospun nanofibers adhered onto the underlying layers before undergoing sulfurization at 500 °C to produce a three-dimensional web-like fibrous CuInS2 film. This fibrous film was characterized by scanning electron microscopy, X-ray diffraction, and Auger electron spectroscopy, thereby characterizing the 3D fibrous nanostructure of the CuInS2 film. This 3D structure could lead to next-generation solar cells optimized for maximal charge separation to enhance photovoltaic efficiency of solution-processed thin film solar cells

  15. Towards modelling of the frictional behaviour of deforming fibrous tows: A geometrical approach

    Cornelissen, Bo; Akkerman, Remko

    2010-01-01

    Fibrous tows used in continuous fibre-reinforced polymers (CFRPs) deform geometrically during the production of composite products. The cross-sectional geometry of the tow is influenced by the load-induced deformation mechanisms. A study of the effect of two commonly assumed geometrical tow shapes o

  16. Towards high performance and multi-functional structural membranes using advanced fibrous and textile materials

    Fangueiro, Raúl; Rana, Sohel

    2015-01-01

    Scientific and technological advancements in the area of fibrous and textile materials have greatly enhanced their application potential in several high-end technical and industrial sectors including construction, transportation, medical, sports, aerospace engineering, electronics and so on. Excellent performance accompanied by light-weight, mechanical flexibility, tailor-ability, design flexibility, easy fabrication and relatively lower cost are the driving force...

  17. Experimental and theoretical studies on high-temperature thermal properties of fibrous insulation

    In the present paper, an experimental apparatus has been developed to measure heat transfer through high-alumina fibrous insulation for thermal protection system. Effective thermal conductivities of the fibrous insulation were measured over a wide range of temperature (300-973 K) and pressure (10-2-105 Pa) using the developed apparatus. The specific heat and the transmittance spectra in the wavelength range of 2.5-25 μm were also measured. The spectral extinction coefficients and Rosseland mean extinction coefficients were obtained from transmittance data at various temperatures to investigate the radiative heat transfer in fibrous insulation. A one-dimensional finite volume numerical model combined radiation and conduction heat transfer was developed to predict the behavior of the effective thermal conductivity of the fibrous insulation at various temperatures and pressures. The two-flux approximation was used to model the radiation heat transfer through the insulation. The experimentally measured specific heat and Rosseland mean extinction coefficients were used in the numerical heat transfer model to calculate the effective thermal conductivity. The average deviation between the numerical results for different values of albedo of scattering and the experimental results was investigated. The numerical results for ω=1 and experimental data were compared. It was found that the calculated values corresponded with the experimental values within an average of 13.5 percent. Numerical results were consistent with experimental results through the environmental conditions under examination

  18. Dissolving behavior and calcium release from fibrous wollastonite in acetic acid solution

    The degradability of fibrous wollastonite (CaSiO3) in an aqueous solution of acetic acid and leaching of Ca2+ ions were investigated in the temperature range from 22 to 50 oC. The Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-OES) was used for the assessment of calcium and other selected cations in the leaching medium. The amount of calcium in the solvent can be significantly enhanced through leaching at higher temperature. Fibrous silica particles are the main by-product of the leaching process. The properties of by-product were examined by thermal analysis (simultaneous TG-DTA-EGA), infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The formation of silica layer on the surface of fibrous wollastonite particles is an important factor in the leaching process. Particles were covered by the silica layer and wollastonite core size was continually decreasing during leaching. The shape of resulting silica particles shows no significant changes during this process. Specific surface of the formed fibrous silica particles strongly depends on the leaching temperature.

  19. A novel apparatus for countercurrent sorption separation processes using fibrous sorbents

    Diederen, A.M.; Zee, G. van; Veenman, A.W.; Graauw, J. de

    1998-01-01

    This paper discusses a technical feasibility study on continuous countercurrent sorption equipment using mechanically transported fibrous sorbent materials such as fiber beds and open-cell foam. A pilot unit was developed and tested and the apparatus performed adequately. Under the conditions applie

  20. Acoustic and Visul Study of Bubble Formation Processes in Bubble Columns Staged with Fibrous Catalytic Layers

    Höller, V.; Růžička, Marek; Drahoš, Jiří; Kiwi-Minsker, L.; Renken, A.

    79-80, - (2003), s. 151-157. ISSN 0920-5861 Institutional research plan: CEZ:AV0Z4072921 Keywords : bubble formation * fibrous catalytic layers * staged bubble column Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 2.627, year: 2003

  1. CARBONIZED FIBROUS RESIN AS A NEW SORBENT FOR SAMPLING POLYCYCLIC AROMATIC HYDROCARBONS (PAHS) IN AMBIENT AIR

    2002-01-01

    A new sampling method of ambient air analysis using carbonized fibrous resin as asorbent for polycyclic aromatic hydrocarbons (PAHs) was reported.The physical and chemical properties of the carbonized fibrous resins were measured. Thesample pretreatment with ultrasonic extraction and subsequent clean-up ehition through a silica gelcolumn was optimized. The suitable ultrasonic extraction conditions were selected as follows: resinweight was 1.5 g, ultrasonic extraction time 20 min, volume of extraction solvent 100 mi andextraction operation times 2~3. The concentrated extractable organic matter was submitted to nextstep of clean-up procedure of adsorption chromatography on silica gel column/n-hexane and amixture of dichloromethene:n-hexane solution 2:3 (v/v). The PAHs fractions in the real samplesfrom Changzhou, China were particularly analyzed using GC-MS data system and the data of massspectra, retention times and scan numbers of the real samples were compared with that of thestandards of 16 PAHs listed by the US EPA as "priority pollutants" of the environment. Theanalysis of the real samples indicates that the carbonized fibrous resin is a good sorbent. Thepretreatment of samples of ambient air with carbonized fibrous resin as a sorbent for P,AHs isproved to be reliable and might be used for the procedure of the determination of PAHs inatmospheric environment.

  2. Cell alignment induced by anisotropic electrospun fibrous scaffolds alone has limited effect on cardiomyocyte maturation

    Jingjia Han

    2016-05-01

    Full Text Available Enhancing the maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs will facilitate their applications in disease modeling and drug discovery. Previous studies suggest that cell alignment could enhance hPSC-CM maturation; however, the robustness of this approach has not been well investigated. To this end, we examined if the anisotropic orientation of hPSC-CMs imposed by the underlying aligned fibers within a 3D microenvironment could improve the maturation of hPSC-CMs. Enriched hPSC-CMs were cultured for two weeks on Matrigel-coated anisotropic (aligned and isotropic (random polycaprolactone (PCL fibrous scaffolds, as well as tissue culture polystyrenes (TCPs as a control. As expected, hPSC-CMs grown on the two types of fibrous scaffolds exhibited anisotropic and isotropic orientations, respectively. Similar to cells on TCPs, hPSC-CMs cultured on these scaffolds expressed CM-associated proteins and were pharmacologically responsive to adrenergic receptor agonists, a muscarinic agonist, and a gap junction uncoupler in a dose-dependent manner. Although hPSC-CMs grown on anisotropic fibrous scaffolds displayed the highest expression of genes encoding a number of sarcomere proteins, calcium handling proteins and ion channels, their calcium transient kinetics were slower than cells grown on TCPs. These results suggest that electrospun anisotropic fibrous scaffolds, as a single method, have limited effect on improving the maturation of hPSC-CMs.

  3. Cell alignment induced by anisotropic electrospun fibrous scaffolds alone has limited effect on cardiomyocyte maturation

    Han, Jingjia; Wu, Qingling; Xia, Younan; Wagner, Mary B; Xu, Chunhui

    2016-01-01

    Enhancing the maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) will facilitate their applications in disease modeling and drug discovery. Previous studies suggest that cell alignment could enhance hPSC-CM maturation; however, the robustness of this approach has not been well investigated. To this end, we examined if the anisotropic orientation of hPSC-CMs imposed by the underlying aligned fibers within a 3D microenvironment could improve the maturation of hPSC-CMs. Enriched hPSC-CMs were cultured for two weeks on Matrigel-coated anisotropic (aligned) and isotropic (random) polycaprolactone (PCL) fibrous scaffolds, as well as tissue culture polystyrenes (TCPs) as a control. As expected, hPSC-CMs grown on the two types of fibrous scaffolds exhibited anisotropic and isotropic orientations, respectively. Similar to cells on TCPs, hPSC-CMs cultured on these scaffolds expressed CM-associated proteins and were pharmacologically responsive to adrenergic receptor agonists, a muscarinic agonist, and a gap junction uncoupler in a dose-dependent manner. Although hPSC-CMs grown on anisotropic fibrous scaffolds displayed the highest expression of genes encoding a number of sarcomere proteins, calcium handling proteins and ion channels, their calcium transient kinetics were slower than cells grown on TCPs. These results suggest that electrospun anisotropic fibrous scaffolds, as a single method, have limited effect on improving the maturation of hPSC-CMs. PMID:27131761

  4. Effects of Milling on the Fibrous Structure and Mechanical Behaviors of a Collagen Material--Leather

    Leather, a fibrous collagen material, is a high value coproduct of the meat industry. Milling is being practiced in the tannery to mechanically tumble and therefore soften leather for adequate stiffness and feel. However, there is no report regarding its effects on the structure change and physica...

  5. Fibrous tumours in children: imaging features of a heterogeneous group of disorders

    Background. Fibrous tumours are predominantly soft tissue lesions which are relatively frequent in childhood but are little known. Imaging is often used in the evaluation of these tumours but their characteristics, particularly on US or MRI, have not been studied systematically. Objectives. To provide an overview of the clinical and imaging features of the different disorders, and to correlate them with the currently used classification schemes. Material and methods. Twenty-five patients with fibrous tumours were evaluated retrospectively. Clinical histories were studied for the histopathological diagnosis, age, signs and symptoms at presentation, mode of therapy and follow-up where available. Imaging findings were analysed for the following variables: number, location, size, margin and architecture of soft tissue and/or visceral lesions and the presence and pattern of osseous involvement. Comparison with the available literature was performed. Results. The following tumour types were encountered: desmoid fibromatosis (n = 9), myofibromatosis (n = 7), fibromatosis colli (n = 2), congenital-infantile fibrosarcoma (n = 2), adult-type fibrosarcoma (n = 2), fibrous hamartoma of infancy (n = 1), angiofibroma (n = 1) and hyaline fibromatosis (n = 1). Conclusions. While some tumours were non-specific in their clinical and radiological manifestation, others such as myofibromatosis, fibromatosis colli, fibrous hamartoma of infancy and angiofibroma exhibited a characteristic pattern which allowed a diagnosis to be made even without histology. (orig.)

  6. The internal microstructure and fibrous mineralogy of fly ash from coal-burning power stations

    Coal fly ash (CFA) is a significant environmental pollutant that presents a respiratory hazard when airborne. Although previous studies have identified the mineral components of CFA, there is a paucity of information on the structural habits of these minerals. Samples from UK, Polish and Chinese power stations were studied to further our understanding of the factors that affect CFA geochemistry and mineralogy. ICP-MS, FE-SEM/EDX, XRD, and laser diffraction were used to study physicochemical characteristics. Analysis revealed important differences in the elemental compositions and particle size distributions of samples between sites. Microscopy of HF acid-etched CFA revealed the mullite present possesses a fibrous habit; fibres ranged in length between 1 and 10 μm. Respirable particles (<10 μm) were frequently observed to contain fibrous mullite. We propose that the biopersistence of these refractory fibres in the lung environment could be contributing towards chronic lung diseases seen in communities and individuals continually exposed to high levels of CFA. - Highlights: → Chinese CFA had a greater crystalline mineral content and smaller particle size. → Mullite and quartz, two hazardous minerals, recrystallise from glass melt particles. → Mullite revealed a fibrous habit, with fibres 1-10 μm in length and 0.5-1 μm in width. - Chinese CFA possessed a greater crystalline mineral content and smaller particle size than UK and Polish CFA, the fibrous mullite prhiesent displayed a high aspect-ratio and thus is likely to be a respiratory hazard in vivo.

  7. Hydrogen peroxide production from fibrous pectic cellulose analogs and effect on dermal fibroblasts

    Naturally derived products with folklore remedies have in recent years been reconsidered for their benefit to wound healing i.e., honey’s application to chronic wound dressing products. Similarly, we have undertaken an evaluation of Fibrous pectin-cellulose (FPC) (cellulose blended with primary cel...

  8. Combined Heat Transfer in High-Porosity High-Temperature Fibrous Insulations: Theory and Experimental Validation

    Daryabeigi, Kamran; Cunnington, George R.; Miller, Steve D.; Knutson, Jeffry R.

    2010-01-01

    Combined radiation and conduction heat transfer through various high-temperature, high-porosity, unbonded (loose) fibrous insulations was modeled based on first principles. The diffusion approximation was used for modeling the radiation component of heat transfer in the optically thick insulations. The relevant parameters needed for the heat transfer model were derived from experimental data. Semi-empirical formulations were used to model the solid conduction contribution of heat transfer in fibrous insulations with the relevant parameters inferred from thermal conductivity measurements at cryogenic temperatures in a vacuum. The specific extinction coefficient for radiation heat transfer was obtained from high-temperature steady-state thermal measurements with large temperature gradients maintained across the sample thickness in a vacuum. Standard gas conduction modeling was used in the heat transfer formulation. This heat transfer modeling methodology was applied to silica, two types of alumina, and a zirconia-based fibrous insulation, and to a variation of opacified fibrous insulation (OFI). OFI is a class of insulations manufactured by embedding efficient ceramic opacifiers in various unbonded fibrous insulations to significantly attenuate the radiation component of heat transfer. The heat transfer modeling methodology was validated by comparison with more rigorous analytical solutions and with standard thermal conductivity measurements. The validated heat transfer model is applicable to various densities of these high-porosity insulations as long as the fiber properties are the same (index of refraction, size distribution, orientation, and length). Furthermore, the heat transfer data for these insulations can be obtained at any static pressure in any working gas environment without the need to perform tests in various gases at various pressures.

  9. Malignant neurilemoma with xeroderma pigmentosum

    Wang, Li Na; Ma, Min Jian; Shi, Ji Tong

    2009-01-01

    Xeroderma pigmentosum is a rare autosomal recessive disease characterised by hypersensitivity to sunlight, and is associated with a high incidence of skin cancer. We report a case of xeroderma pigmentosum with malignant neurilemoma in a 46-year-old woman which is unique due to its presentation, which was confirmed histopathologically.

  10. Herniation of malignant lung cavity

    Saurabh Kumar Singh; Rakesh Bhargava; Zuber Ahmad; Deepak K.Pandey; Shirin Naaz; Vibhanshu Gupta

    2008-01-01

    @@ Hernia of the lung is defined as a protrusion of lung tissue,covered by parietal and visceral pleurae,through an abnormal opening in the chest wall,diaphragm or mediastinum.1 It is a relatively uncommon condition.We report a case of lung hernia following cavitation in malignant lung mass.

  11. The Origin of Malignant Malaria

    Plasmodium falciparum is the causative agent of malignant malaria, which is among the most severe human infectious diseases. Despite its overwhelming significance to human health, the parasite’s origins remain unclear. The favored origin hypothesis holds that P. falciparum and its closest known rel...

  12. Cutaneous manifestations of internal malignancy

    A Ayyamperumal

    2012-01-01

    Full Text Available Background: Many malignancies affecting the internal organs display cutaneous manifestations which may be either specific (tumor metastases or nonspecific lesions. Aims: The study is aimed at determining the frequency and significance of cutaneous manifestations among patients with internal malignancy. Materials and Methods: 750 cases of proven internal malignancy, who attended a cancer chemotherapy center in South India, were studied. Specific infiltrates were confirmed by histopathology, fine needle aspiration cytology (FNAC and marker studies. Results: Out of the 750 patients with internal malignancy, skin changes were seen in a total of 52 (6.93% patients. Conclusion: Cutaneous metastases (specific lesions were seen in 20 patients (2.66%: contiguous in 6 (0.8%, and non-contiguous in 14 (1.86%. Nonspecific skin changes were seen in 32 patients (4.26%. None of our patients presented with more than one type of skin lesions. Herpes zoster was the most common nonspecific lesion noticed in our patients, followed by generalized pruritus, multiple eruptive seborrheic keratoses, bullous disorder, erythroderma, flushing, purpura, pyoderma gangrenosum, insect bite allergy and lichenoid dermatitis.

  13. MALIGNANCY IN LARGE COLORECTAL LESIONS

    Carlos Eduardo Oliveira dos SANTOS

    2014-09-01

    Full Text Available Context The size of colorectal lesions, besides a risk factor for malignancy, is a predictor for deeper invasion Objectives To evaluate the malignancy of colorectal lesions ≥20 mm. Methods Between 2007 and 2011, 76 neoplasms ≥20 mm in 70 patients were analyzed Results The mean age of the patients was 67.4 years, and 41 were women. Mean lesion size was 24.7 mm ± 6.2 mm (range: 20 to 50 mm. Half of the neoplasms were polypoid and the other half were non-polypoid. Forty-two (55.3% lesions were located in the left colon, and 34 in the right colon. There was a high prevalence of III L (39.5% and IV (53.9% pit patterns. There were 72 adenomas and 4 adenocarcinomas. Malignancy was observed in 5.3% of the lesions. Thirty-three lesions presented advanced histology (adenomas with high-grade dysplasia or early adenocarcinoma, with no difference in morphology and site. Only one lesion (1.3% invaded the submucosa. Lesions larger than 30 mm had advanced histology (P = 0.001. The primary treatment was endoscopic resection, and invasive carcinoma was referred to surgery. Recurrence rate was 10.6%. Conclusions Large colorectal neoplasms showed a low rate of malignancy. Endoscopic treatment is an effective therapy for these lesions.

  14. Malignant nodular hidradenoma of scalp

    Tanmoy Maiti

    2014-01-01

    Full Text Available Malignant nodular hidradenoma (MNH is a rare tumor of sweat gland known by many names in the literature. Scalp is a known and yet uncommon site of occurrence. We describe two patients with scalp MNH with brain parenchymal invasion. Both tumors recurred in spite of total excision and radiotherapy.

  15. Malignant pleural effusions. Bibliographic revision

    Malignant pleural effusions are a common clinical problem in patients with neoplastic disease. Dyspnea is the most common symptom. The diagnostic is made with X ray and pleural echography. The treatment are thoracentesis, chest tube drainage and pleurodesis. Palliative therapy should be considered, necessitating evaluation of the patient's symptoms, general health and functional status, and expected survival. (The author)

  16. Neuroleptic Malignant Syndrome: A Review

    O'Brien, Richard A.; Young, G. Bryan

    1989-01-01

    There has recently been interest in neuroleptic malignant syndrome (NMS) as the disorder has been better characterized. Nms is still poorly recognized, however, by most physicians. Hyperpyrexia, rigidity, altered consciousness, autonomic instability, and enzymatic evidence of muscle breakdown after drug intake are the cardinal features. The authors of this article review the proposed pathogenesis, complications, and treatment of NMS.

  17. Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

    2016-08-03

    Adult Fibrosarcoma; Alveolar Soft Part Sarcoma; Angiomatoid Fibrous Histiocytoma; Atypical Fibroxanthoma; Clear Cell Sarcoma of Soft Tissue; Epithelioid Malignant Peripheral Nerve Sheath Tumor; Epithelioid Sarcoma; Extraskeletal Myxoid Chondrosarcoma; Extraskeletal Osteosarcoma; Fibrohistiocytic Neoplasm; Glomus Tumor of the Skin; Inflammatory Myofibroblastic Tumor; Intimal Sarcoma; Leiomyosarcoma; Liposarcoma; Low Grade Fibromyxoid Sarcoma; Low Grade Myofibroblastic Sarcoma; Malignant Cutaneous Granular Cell Tumor; Malignant Peripheral Nerve Sheath Tumor; Malignant Triton Tumor; Mesenchymal Chondrosarcoma; Myxofibrosarcoma; Myxoid Chondrosarcoma; Myxoinflammatory Fibroblastic Sarcoma; Nerve Sheath Neoplasm; PEComa; Pericytic Neoplasm; Plexiform Fibrohistiocytic Tumor; Sclerosing Epithelioid Fibrosarcoma; Stage IB Soft Tissue Sarcoma; Stage IIB Soft Tissue Sarcoma; Stage III Soft Tissue Sarcoma; Stage IV Soft Tissue Sarcoma; Synovial Sarcoma; Undifferentiated (Embryonal) Sarcoma; Undifferentiated High Grade Pleomorphic Sarcoma of Bone

  18. Do We Know What Causes Malignant Mesothelioma?

    ... Next Topic Can malignant mesothelioma be prevented? Do we know what causes malignant mesothelioma? Researchers have found ... genes – the instructions for how our cells function. We usually look like our parents because they are ...

  19. PELVIC ACTINOMYCOSIS MIMICKING A LOCALLY ADVANCED PELVIC MALIGNANCY--CASE REPORT.

    Velenciuc, Natalia; Velenciuc, I; Makkai Popa, S; Roată, C; Ferariu, D; Luncă, S

    2016-01-01

    We present the case of a former user of an intrauterine contraceptive device (IUD) for 10 years, diagnosed with a bulky, fixed pelvic tumor involving the internal genital organs and the recto sigmoid, causing luminal narrowing of the rectum, interpreted as locally advanced pelvic malignancy, probably of genital origin. Intraoperatively, a high index of suspicion made us collect a sample from the fibrous wall of the tumor mass, large Actinomyces colonies were thus identified. Surgery consisted in debridement, removal of a small amount of pus and appendectomy, thus avoiding a mutilating and useless surgery. Specific antibiotic therapy was administered for 3 months, with favorable postoperative and long-term outcomes. Pelvic actinomycosis should always be considered in the differential diagnosis of pelvic tumors in women using an IUD. The association of long-term antibiotic treatment is essential to eradicate the infection and prevent relapses. PMID:27483724

  20. Desmoplastic malignant mesothelioma of the pericardium: Description of a case and review of the literature

    Antonello Nicolini

    2011-01-01

    Full Text Available Desmoplastic mesothelioma (DMM is a rare and highly lethal subtype of diffuse malignant mesothelioma and is often difficult to distinguish from reactive pleural fibrosis. The term "desmoplastic" refers to the growth of fibrous or connective tissue. We report the clinical, radiological, and pathological features of a primary DMM of the pericardium and a short review of the literature. A 72-year-old man was admitted presenting shortness of breath, cough, and asthenia. Computed tomography scan showed thickenings and effusions both in the pleura and in the pericardium. Histopathological diagnosis was performed by surgical pericardial biopsy and confirmed by autopsy. The patient had a history of asbestos exposure. Primary mesothelioma of the pericardium is a rare tumor occurring in the fourth to seventh decades with nonspecific symptoms and a rapid clinical course. The diagnosis is difficult and often needing a surgical pericardial biopsy. The prognosis is poor although newer antiblastic drugs seem to prolong survival times.

  1. Serum ferritin in liver and bone malignancy

    Serum ferritin concentration is increased during iron overload, however, during chronic infection and malignant diseases as well. In 383 patients with proven malignancy or suspicion of a malignant disease liver and/or bone scans were performed and serum ferritin was measured in addition. Although there exists a certain linkage between the tumorous disease and serum ferritin level, a definite correlation does not exist. Furthermore serum ferritin is not a measure to differentiate between infectious and malignant diseases. (orig.)

  2. Long-term Continuous Production of Monoclonal Antibody by Hybridoma Cells Immobilized in a Fibrous-Bed Bioreactor

    Zhu, Hui; Yang, Shang-Tian

    2004-01-01

    The kinetics and long-term stability of continuous production of monoclonal antibody IgG2b by hybridoma HD-24 cells immobilized in a fibrous-bed bioreactor (FBB) were studied for a period of ∼8 months. The cells were immobilized in the fibrous bed by surface attachment of cells and entrapment of large cell clumps in the void space of the fibrous matrix. A high viable cell density of 1.01 × 108/ml was attained in the bioreactor, which was about 63 times higher than those in conventional T-flas...

  3. New MRI techniques for staging malignant lymphoma

    Kwee, T.C.

    2011-01-01

    Malignant lymphomas are a heterogenous group of malignancies, belonging to the ten most frequent types of cancers worldwide. Once a malignant lymphoma has been diagnosed, it is important to assess disease extent (staging), because this has prognostic and therapeutic implications. Computed tomography

  4. Renal cell carcinoma presenting with malignant ascites

    Jennison, Erica; Wathuge, Gayathri W; Gorard, David A

    2015-01-01

    Lesson It is rare for renal cell carcinoma to involve the peritoneum and cause malignant ascites. Furthermore, it is uncommon for malignant ascites to be a presenting feature of this cancer. An unusual case of renal cell carcinoma presenting with malignant ascites is reported, and its response to sunitinib described.

  5. Surface chemistry and surface reactivity of fibrous amphiboles that are not regulated as asbestos

    Fantauzzi, M.; Rossi, A. [Universita di Cagliari, ' ' Dipartimento di Scienze Chimiche e Geologiche' ' Centro Grandi Strumenti, Cagliari (Italy); INSTM unit, Monserrato, Cagliari (Italy); Pacella, A.; Gianfagna, A.; Andreozzi, G.B. [Sapienza Universita di Roma, Dipartimento di Scienze della Terra, Roma (Italy); Fournier, J. [Laboratoire de Reactivite de Surface, ' ' Le St Raphael' ' , UPMC Paris VI, UMR 7197, Ivry-sur-Seine, Paris (France)

    2012-08-15

    Three fibrous amphiboles that are not regulated as asbestos - two from Biancavilla (Sicily, Italy) and one from Libby (MT, USA) - were studied in order to establish relationships between surface chemistry and surface reactivity. The three fibrous samples, plus one prismatic fluoro-edenite from Biancavilla that was used for comparison, were investigated by X-ray photoelectron spectroscopy (XPS) in order to obtain their quantitative surface compositions and to determine the chemical environment of the Fe in each case. In particular, the Fe 2p{sub 3/2} peak was fitted and, for the first for these materials, the binding energies of Fe(II) oxide, Fe(III) oxide and Fe(III) oxyhydroxide were identified. Bulk chemistries and Fe oxidation states were obtained from previous studies for the samples from Biancavilla, and were investigated in the present work by electron microprobe (EMP) and {sup 57}Fe Moessbauer spectroscopy (MS) for the sample from Libby. Comparison between surface and bulk data revealed that the sample with the lowest bulk Fe oxidation state was the one most affected by surface oxidation, while the samples with bulk highly-oxidised Fe were showing very high signal of Fe (III) oxy-hydroxide probably due to weathering. The surface reactivities of the fibrous amphiboles were investigated by measuring the production of the [DMPO, HO] circle radical adduct using electron paramagnetic resonance (EPR) spectroscopy. Notably, significant chemical reactivity was observed; it was found to be comparable with - or, for the Libby sample, even higher than - that of fibrous tremolite (one of the six asbestos minerals). A positive linear correlation was observed when the production of HO circle radical was plotted versus the Fe(II) content on the fibre surface. Data on fibrous tremolite obtained from previous studies were added to substantiate the correlation. These results provide evidence that Fe(II) at the fibre surface controls the production of radicals at the fibre

  6. Tumor Metabolism of Malignant Gliomas

    Deliang Guo

    2013-11-01

    Full Text Available Constitutively activated oncogenic signaling via genetic mutations such as in the EGFR/PI3K/Akt and Ras/RAF/MEK pathways has been recognized as a major driver for tumorigenesis in most cancers. Recent insights into tumor metabolism have further revealed that oncogenic signaling pathways directly promote metabolic reprogramming to upregulate biosynthesis of lipids, carbohydrates, protein, DNA and RNA, leading to enhanced growth of human tumors. Therefore, targeting cell metabolism has become a novel direction for drug development in oncology. In malignant gliomas, metabolism pathways of glucose, glutamine and lipid are significantly reprogrammed. Moreover, molecular mechanisms causing these metabolic changes are just starting to be unraveled. In this review, we will summarize recent studies revealing critical gene alterations that lead to metabolic changes in malignant gliomas, and also discuss promising therapeutic strategies via targeting the key players in metabolic regulation.

  7. CT triage for lung malignancy

    Kusk, Martin Weber; Karstoft, Jens; Mussmann, Bo

    2015-01-01

    Background: Generation of multiplanar reformation (MPR) images has become automatic on most modern computed tomography (CT) scanners, potentially increasing the workload of the reporting radiologists. It is not always clear if this increases diagnostic performance in all clinical tasks. Purpose: To...... patients with suspicion of lung cancer, scanned on 64-slice multidetector computed tomography (MDCT) with images reconstructed in three planes. Coronal images were presented to four readers, two novice and two experienced. Readers decided whether the patients were suspicious for malignant disease, and...... assess detection performance using only coronal multiplanar reformations (MPR) when triaging patients for lung malignancies with CT compared to images in three orthogonal planes, and to evaluate performance comparison of novice and experienced readers. Material and Methods: Retrospective study of 63...

  8. Tumor Metabolism of Malignant Gliomas

    Ru, Peng; Williams, Terence M.; Chakravarti, Arnab; Guo, Deliang, E-mail: deliang.guo@osumc.edu [Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center & Arthur G James Cancer Hospital, Columbus, OH 43012 (United States)

    2013-11-08

    Constitutively activated oncogenic signaling via genetic mutations such as in the EGFR/PI3K/Akt and Ras/RAF/MEK pathways has been recognized as a major driver for tumorigenesis in most cancers. Recent insights into tumor metabolism have further revealed that oncogenic signaling pathways directly promote metabolic reprogramming to upregulate biosynthesis of lipids, carbohydrates, protein, DNA and RNA, leading to enhanced growth of human tumors. Therefore, targeting cell metabolism has become a novel direction for drug development in oncology. In malignant gliomas, metabolism pathways of glucose, glutamine and lipid are significantly reprogrammed. Moreover, molecular mechanisms causing these metabolic changes are just starting to be unraveled. In this review, we will summarize recent studies revealing critical gene alterations that lead to metabolic changes in malignant gliomas, and also discuss promising therapeutic strategies via targeting the key players in metabolic regulation.

  9. Giant melanoacanthoma mimicking malignant melanoma

    Vikas Shankar

    2011-01-01

    Full Text Available Melanoacanthoma denotes a rare variant of pigmented seborrheic keratosis. A 65-year-old male farmer had pigmented, verrucous, itchy, highly painful, progressively growing irregularly oval plaque on left side of lower back for the past five years. The indurated lesion, measuring maximum diameter 10 cm Χ 5 cm, had no discharge, bleeding, ulceration, or associated lymphadenopathy. Dermoscopy showed regular pigmentary network and cribiform pattern of ridges without any feature of malignant melanoma. Histopathology showed well-defined islands of basaloid cells interspersed with large and richly dendritic melanocytes. The lesion was totally excised followed by skin grafting. Our patient was unique in its massive size and clinical resemblance with malignant melanoma. The diagnosis was confirmed by dermoscopy and skin biopsy.

  10. Paediatric and adult malignant glioma

    Jones, Chris; Perryman, Lara; Hargrave, Darren

    2012-01-01

    Gliomas in children differ from their adult counterparts by their distribution of histological grade, site of presentation and rate of malignant transformation. Although rare in the paediatric population, patients with high-grade gliomas have, for the most part, a comparably dismal clinical outcome...... to older patients with morphologically similar lesions. Molecular profiling data have begun to reveal the major genetic alterations underpinning these malignant tumours in children. Indeed, the accumulation of large datasets on adult high-grade glioma has revealed key biological differences between...... the adult and paediatric disease. Furthermore, subclassifications within the childhood age group can be made depending on age at diagnosis and tumour site. However, challenges remain on how to reconcile clinical data from adult patients to tailor novel treatment strategies specifically for paediatric...

  11. Vulvar Malignancy in Neurofibromatosis Syndrome

    Angela Musella

    2013-01-01

    Full Text Available Type 1 neurofibromatosis (NF1 is a dominantly inherited neurologic disorder that affects primarily the skin, bones, and peripheral nervous system. It may be associated with a variety of clinical manifestations including cafe-au-lait spots, skinfold freckling, Lisch nodules, and visceral neurofibromas. Individuals affected by NF1 harbor an increased risk for both benign and malignant tumors. Malignant transformation is usually observed in the form of neurosarcoma. Rarely, NF1 affects the genital tract, and isolated vulvar localization is extremely rare. Here is reported a rare case of a solitary neurosarcoma of the vulva in a 43-year-old woman affected by NF1 syndrome treated with surgical excision. The purpose of this case is to underline the possibility of association between NF1 and genital tract sarcoma and to suggest an accurate evaluation of rapid growth vulvar mass in this setting.

  12. Clostridium difficile in haematological malignancy.

    Rampling, A.; Warren, R. E.; Bevan, P C; Hoggarth, C E; Swirsky, D; Hayhoe, F G

    1985-01-01

    Twenty patients with haematological malignancies who developed Clostridium difficile bowel infection or colonisation are described. All isolates of C difficile were toxigenic in vitro and faecal cytotoxin (toxin B) was detected in 20/26 episodes. Ten of 20 episodes with detectable faecal cytotoxin were associated with typical antibiotic associated diarrhoea. In the other 10 episodes (nine patients), there was a severe unusual illness which was associated with detection of C difficile. The unu...

  13. Transcatheter therapy for malignant neoplasms.

    Coldwell, D M; Mortimer, J E

    1989-01-01

    Interventional radiology has developed into a subspecialty with application in the treatment and palliation of patients with advanced malignant diseases. A directed catheter delivers high concentrations of chemotherapy directly into the tumor bed. Embolic particles may be injected to stop hemorrhage or to occlude the blood supply of a cancer, resulting in pain relief or tumor shrinkage. These techniques can be incorporated into a multidisciplinary approach to cancer.

  14. Malignant endobronchial lesions of adolescence

    Rare primary endobronchial malignancies were diagnosed in four adolescents: atypical bronchial carcinoid, mucoepidermoid carcinoma, bronchogenic (squamous cell) carcinoma, and non-Hodgkin's lymphoma. Metastatic disease was evident in each case. Three of the four patients died within one year of diagnosis. This paper describes each of these entities, illustrates their plain film and CT abnormalities (bronchial 'cut-off', hilar mass, local congestive edema, lobar collapse, hyperinflation), and discusses the utility of CT in their diagnosis. (orig.)

  15. MALIGNANT MELANOMA – CUTANEOUS METASTASES

    Padmavathy, L; Lakshmana Rao, L; Ethirajan, N; Krishna Swamy, B

    2008-01-01

    Melanoma composed of melanocytes may arise in the skin or other tissues harboring melanocytes, such muco-cutaneous junctions, mucosa including the conjunctiva, iris, choroids and substantia nigra.1 Metastases to the skin and subcutaneous tissues from a malignant melanoma are less common. A case of multiple painless nodules on the body that revealed metastatic deposits of melanoma on histopathological examination is being reported. PMID:19882041

  16. Malignant endobronchial lesions of adolescence

    Bellah, R.D. (Dept. of Radiology, Children' s Hospital of Philadelphia, PA (United States)); Mahboubi, S. (Dept. of Radiology, Children' s Hospital of Philadelphia, PA (United States)); Berdon, W.E. (Dept. of Radiology, Babies Hospital/Columbia Presbyterian Medical Center, New York, NY (United States))

    1992-12-01

    Rare primary endobronchial malignancies were diagnosed in four adolescents: atypical bronchial carcinoid, mucoepidermoid carcinoma, bronchogenic (squamous cell) carcinoma, and non-Hodgkin's lymphoma. Metastatic disease was evident in each case. Three of the four patients died within one year of diagnosis. This paper describes each of these entities, illustrates their plain film and CT abnormalities (bronchial 'cut-off', hilar mass, local congestive edema, lobar collapse, hyperinflation), and discusses the utility of CT in their diagnosis. (orig.)

  17. Amisulpride and Neuroleptic Malignant Syndrome

    Ming-Che Tu; Cheng-Cheng Hsiao

    2011-01-01

    Neuroleptic malignant syndrome (NMS) is a rare but lethal complication of neuroleptics. Its incidence ranges between 0.02% and 3%. Amisulpride, a second generation neuroleptic, was associated with rhabdomyolysis in one report and NMS in 2 reports. Althoughthe precise pathogenesis is still unclear, dopamine receptor blockade is theorized to play acentral role. Conventional presentations include hyperthermia, muscle rigidity, and elevatedcreatine kinase concentrations. However, similar to other...

  18. Malignant melanoma of the vulva

    Ragnarsson Olding, Boel

    1999-01-01

    From a consecutive, nationwide series of 219 females with primary vulvar malignant melanomas diagnosed in Sweden during 1960 to 1984 and followed up until 1994, we analyzed epidemiological, clinical, histopathological, prognostic and molecular genetic data. The age-standardized incidence among these patients, 75 % of whom were 60 years old or more, decreased by 3.2 % annually compared to an increase of almost 6 % for contemporary cutaneous melanomas in Sweden. Relative 5-and...

  19. [Malignant wounds in palliative care].

    Fromantin, Isabelle; Rollot, Florence; Nicodeme, Marguerite; Kriegel, Iréne

    2015-01-01

    In the alsence of effective cancer treatment, malignant wounds evolve. The decisions taken by the multi-disciplinary team with regard to their care vary depending on whether the patient is in the initial, advanced or terminal phase of palliative care. Modern dressings can be used to control bleeding, odours and drainage. The aim is to control the symptoms and improve the quality of life, until its end. PMID:26027186

  20. Height at diagnosis of malignancies.

    Pui, C.H.; Dodge, R K; George, S L; Green, A. A.

    1987-01-01

    Studies of the presenting height of children with malignancies have produced conflicting results, from an excess of taller patients to an excess of shorter patients. The problems of measurement bias, inadequate comparison populations, small numbers of patients, subgroup analyses, and overreliance on simple significance tests are all possible reasons for the variation in results. To clarify this issue, we studied heights at diagnosis of 3657 children and adolescents aged under 18 years. Their ...

  1. Comparative effectiveness in hepatic malignancies.

    Page, Andrew J; Cosgrove, David; Pawlik, Timothy M

    2015-01-01

    The benefits of applying comparative effectiveness research (CER) strategies to the management of cancer are important. As the incidence of cancer increases both in the United States and worldwide, accurate analysis of which tests and treatments should be applied in which situations is critical, both in terms of measurable and meaningful clinical outcomes and health care costs. In the last 20 years alone, multiple controversies have arisen in the diagnosis and treatment of primary and metastatic tumors of the liver, making the management of liver malignancies a prime example of CER. Contributing factors to the development of these controversies include improvements in molecular characterization of these diseases and technological advances in surgery and radiology. The relative speed of these advances has outpaced data from clinical trials, in turn making robust data to inform clinical practice lacking. Indeed, many of the current treatment recommendations for the management of liver malignancies are based primarily on retrospective data. We herein review select CER issues concerning select decision-making topics in the management of liver malignancies. PMID:25677025

  2. Malignant tumours of the vulva

    The thesis analyses 317 patients with vulvar malignancies treated at the University Hospital, Lund, during 1960-1979. The three most common histological types of malignancy have been analysed. The oncological clinic in Lund has since the 1960's used a surgical technique where the primary tumour and the regional lymph nodes are operated on in two separate surgical seances. The vulvectomy is performed with tarm knife technique, and the wound is left open. The 5-year crude survival rate for the entire patient material treated with curative intention was over 60 %, which agrees well with reports from other centres. Our surgical approach using two separate seances has, however, much lower rates of postoperative complications and mortality than the rates in other reports. The overall most important prognostic factors for the patients with invasive vulvar malignancies are the presence of lymphatic metastases at the time of surgery, and the surgical radicality of the primary surgery. The treatment at most stages of tumour development and most histological types should include total vulvectomy preoperative irradiation of the inguinal lymph nodes, and inguinal lymphadenectomy. Only local extirpation and hemivulvectomy are, however, indicated for small microinvasively growing squamous cell carcinoma and basal cell carcinoma. Samll invasive onesided squamous cell carcinoma is best treated with ipsilateral surgery combined with preoperative irradiation of the inguinal lymph nodes. Patients with metastases in the inguinal lymph nodes should receive additional irradiation of the inguinal and pelvic lymph node stations. (Author)

  3. Cooperative, reversible self-assembly of covalently pre-linked proteins into giant fibrous structures.

    Averick, Saadyah; Karácsony, Orsolya; Mohin, Jacob; Yong, Xin; Moellers, Nicholas M; Woodman, Bradley F; Zhu, Weipu; Mehl, Ryan A; Balazs, Anna C; Kowalewski, Tomasz; Matyjaszewski, Krzysztof

    2014-07-28

    We demonstrate a simple bioconjugate polymer system that undergoes reversible self-assembling into extended fibrous structures, reminiscent of those observed in living systems. It is comprised of green fluorescent protein (GFP) molecules linked into linear oligomeric strands through click step growth polymerization with dialkyne poly(ethylene oxide) (PEO). Confocal microscopy, atomic force microscopy, and dynamic light scattering revealed that such strands form high persistence length fibers, with lengths reaching tens of micrometers, and uniform, sub-100 nm widths. We ascribe this remarkable and robust form of self-assembly to the cooperativity arising from the known tendency of GFP molecules to dimerize through localized hydrophobic patches and from their covalent pre-linking with flexible PEO. Dissipative particle dynamics simulations of a coarse-grained model of the system revealed its tendency to form elongated fibrous aggregates, suggesting the general nature of this mode of self-assembly. PMID:25044628

  4. Solitary Fibrous Tumour of the Kidney: Case Report with Review of the Literature

    Kamath, Sulata Manjunath; Nagaraj, HK; Mysorekar, Vijaya V; Patil, Geeta V; Gowri, Mangala

    2013-01-01

    Solitary Fibrous Tumour (SFT) is an unusual spindle cell tumour that usually occurs in the pleura, but has recently also been reported to be extra-pleural in origin. A renal presentation is very rare. Upto 90% of the tumours have benign characteristics. It is difficult to differentiate it from renal cell carcinoma by using imaging techniques. A definitive diagnosis can be made by doing a detailed pathological examination, which includes immunohistochemistry. We are reporting a case of a large solitary fibrous tumour of the kidney which here occurred in a 70-years-old male. Histological examination of the resected specimen confirmed the diagnosis, by revealing strongly positive reactions of the neoplastic cells for CD34, bcl-2, vimentin and negativity for Epithelial Membrane Antigen (EMA), Smooth Muscle Actin (SMA), S-100 protein and Ki-67. The patient suffered a cardiac arrest and died on the seventh day after his surgery. PMID:24551694

  5. PIV-based investigation of the skin friction of the flow over random fibrous media

    Mirbod, Parisa; Gheisari, Reza

    2015-11-01

    Finite Reynolds number (Rebottom wall of the duct along the length of the duct. The flow regime for all tests was laminar, and measurements were all done when the flow reached a steady state. Error and uncertainty sources in the experiments were also discussed. Shear rates were estimated at the surface of the fibrous media. As a conclusion to this study skin friction factor were calculated at the interface of all fibrous media at selected Reynolds number. Then using power function, curve fits with the Cf = a/Re form were found which could closely correlate skin friction and Reynolds number. To weaken the effect of near-wall errors in estimated shear rates and consequently skin friction, an average of shear rate estimation in a layer with thickness of 5 mm was calculated which was used to calculate an average skin friction. Correlations of average skin friction with average Reynolds number were also presented.

  6. Diabetic fibrous breast disease: description of a case with bilateral involvement and gradual spontaneous regression

    We describe the clinica, radiologica and histopathological features of this rare bening breast disease in a 28-year-old patient with a long-standing history of insulin-dependent diabetes mellitus. The patient presented bilateral breast masses, mammography revealed dense breast and ultrasound demonstrated the presence of bilateral anechoic masses with irregular borders and posterior acoustic shadowing. Fine needle aspiration biopsy yielded and amorphous, a cellular hyaline-like material. The histological analysis of surgical biopsy specimens from both breast revealed the presence of keloid fibroblast with lymphocytic lobulitis. The clinical and histological findings suggested the diagnosis of the diabetic fibrous breast disease. Over 8 years of clinical follow-up the masses were seen to regress spontaneously. We confirm the findings reported previously in the literature. suggesting that those patients who fulfill the clinical cytological and imaging criteria for diabetic fibrous breast disease can be managed by clinical means, avoiding the need for surgical biopsy. (Author) 19 refs

  7. Murine Mueller cells are progenitor cells for neuronal cells and fibrous tissue cells

    Mammalian Mueller cells have been reported to possess retinal progenitor cell properties and generate new neurons after injury. This study investigates murine Mueller cells under in vitro conditions for their capability of dedifferentiation into retinal progenitor cells. Mueller cells were isolated from mouse retina, and proliferating cells were expanded in serum-containing medium. For dedifferentiation, the cultured cells were transferred to serum-replacement medium (SRM) at different points in time after their isolation. Interestingly, early cell passages produced fibrous tissue in which extracellular matrix proteins and connective tissue markers were differentially expressed. In contrast, aged Mueller cell cultures formed neurospheres in SRM that are characteristic for neuronal progenitor cells. These neurospheres differentiated into neuron-like cells after cultivation on laminin/ornithine cell culture substrate. Here, we report for the first time that murine Mueller cells can be progenitors for both, fibrous tissue cells and neuronal cells, depending on the age of the cell culture

  8. Theoretical study of the fibrous capsule tissue growth around a disk-shaped implant

    Djellouli, Rabia

    2012-08-19

    We analyze the mathematical properties of the fibrous capsule tissue concentration around a disk-shaped implant. We establish stability estimates as well as monotonicity results that illustrate the sensitivity of this growth to the biocompatibility index parameters of the implant. In addition, we prove that the growth of the tissue increases exponentially in time toward an asymptotic regime. We also study the mathematical properties of the solution of the inverse problem consisting in the determination of the values of the biocompatibility index parameters from the knowledge of some fibrous capsule tissue measurements. We prove that this model calibration problem admits a unique solution, and establish a characterization of the index parameters. Furthermore, we demonstrate analytically that such a solution is not continuous with respect to the data, and therefore the considered inverse problem is ill-posed due to the lack of the stability requirement. © 2012 Springer-Verlag.

  9. Hydraulic permeability of (un)bounded fibrous media using the lattice Boltzmann method

    Several articles have been written regarding the hydraulic permeability of ordered and disordered fibrous media. Here, we explore wall effects on hydraulic permeabilities for ordered and disordered media using the lattice Boltzmann (LB) simulation method. Simulation results are found to be in excellent agreement with the semi analytic result of Sangani and Acrivos, and simulation results for disordered media are in good agreement with the results of Jackson and James and Higdon and Ford's fcc lattice. The macroscopic behavior, the hydraulic permeability, shows a distinct connection with the geometry of the system. This connection is explored and elucidated for ordered and disordered media. Finally, hydraulic permeabilities for bounded media at various wall separations are presented for both ordered and disordered media and results are compared with hydraulic permeabilities calculated for the unbounded media, and a phenomenological correlation is presented to facilitate rapid prediction of hydraulic permeabilities for both unbounded and bounded fibrous media. (c) 2000 The American Physical Society

  10. Aortic periannular abscess invading into the central fibrous body, mitral valve, and tricuspid valve.

    Oh, Hyun Kong; Kim, Nan Yeol; Kang, Min-Woong; Kang, Shin Kwang; Yu, Jae Hyeon; Lim, Seung Pyung; Choi, Jae Sung; Na, Myung Hoon

    2014-06-01

    A 61-year-old man was diagnosed with aortic stenoinsufficiency with periannular abscess, which involved the aortic root of noncoronary sinus (NCS) that invaded down to the central fibrous body, whole membranous septum, mitral valve (MV), and tricuspid valve (TV). The open complete debridement was executed from the aortic annulus at NCS down to the central fibrous body and annulus of the MV and the TV, followed by the left ventricular outflow tract reconstruction with implantation of a mechanical aortic valve by using a leaflet of the half-folded elliptical bovine pericardial patch. Another leaflet of this patch was used for the repair of the right atrial wall with a defect and the TV. PMID:25207228

  11. Filtration efficiency of an electrostatic fibrous filter: Studying filtration dependency on ultrafine particle exposure and composition

    Ardkapan, Siamak Rahimi; Johnson, Matthew S.; Yazdi, Sadegh;

    2014-01-01

    controlled laboratory environment using two different particle counters: a Scanning Mobility Particle Sizer and a NanoTracer. Particles were generated at different concentrations by burning a pure wax candle in a test room. The set-up consisted of a test room, a fan a duct and the particle filter. The......The objective of the present study is to investigate the relationship between ultrafine particle concentrations and removal efficiencies for an electrostatic fibrous filter in a laboratory environment. Electrostatic fibrous filters capture particles efficiently, with a low pressure drop. Therefore...... they have applications in building ventilation systems. The relationship between particle removal efficiency and particle concentration has not been widely investigated in ventilation systems and indoor environments. In order to achieve the objective of this study, experiments were performed in a...

  12. Welcome to Fibers—A New Open Access Journal for Fibrous Material Science

    Stephen C. Bondy

    2012-08-01

    Full Text Available Fibers are materials in the form of elongated threads. They can possess elastic features that are relevant to the integrity and bonding of cells. These features also give man-made fibers a wide range of applications. The large ratio of length to width (aspect ratio, which defines fibers, strongly influences their physical and chemical properties. This quality gives them a relatively large surface area, which can lead to powerful tensile and absorptive characteristics, which are remarkably different from, and cannot be predicted by study of the non-fibrous parent materials. An example of this is asbestos, where the toxicity of the material is heavily influenced by its structural anatomy. Distinctive chemical processes can take place on fibrous surfaces that may themselves seem to be chemically inert. Certain commonalities result from the distinctive geometry of fibers, and lie behind the apparently great diversity of fiber types and materials. [...

  13. Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors

    Griffiths Gary L

    2009-06-01

    Full Text Available Abstract Background The existence of large pores in the blood-tumor barrier (BTB of malignant solid tumor microvasculature makes the blood-tumor barrier more permeable to macromolecules than the endothelial barrier of most normal tissue microvasculature. The BTB of malignant solid tumors growing outside the brain, in peripheral tissues, is more permeable than that of similar tumors growing inside the brain. This has been previously attributed to the larger anatomic sizes of the pores within the BTB of peripheral tumors. Since in the physiological state in vivo a fibrous glycocalyx layer coats the pores of the BTB, it is possible that the effective physiologic pore size in the BTB of brain tumors and peripheral tumors is similar. If this were the case, then the higher permeability of the BTB of peripheral tumor would be attributable to the presence of a greater number of pores in the BTB of peripheral tumors. In this study, we probed in vivo the upper limit of pore size in the BTB of rodent malignant gliomas grown inside the brain, the orthotopic site, as well as outside the brain in temporalis skeletal muscle, the ectopic site. Methods Generation 5 (G5 through generation 8 (G8 polyamidoamine dendrimers were labeled with gadolinium (Gd-diethyltriaminepentaacetic acid, an anionic MRI contrast agent. The respective Gd-dendrimer generations were visualized in vitro by scanning transmission electron microscopy. Following intravenous infusion of the respective Gd-dendrimer generations (Gd-G5, N = 6; Gd-G6, N = 6; Gd-G7, N = 5; Gd-G8, N = 5 the blood and tumor tissue pharmacokinetics of the Gd-dendrimer generations were visualized in vivo over 600 to 700 minutes by dynamic contrast-enhanced MRI. One additional animal was imaged in each Gd-dendrimer generation group for 175 minutes under continuous anesthesia for the creation of voxel-by-voxel Gd concentration maps. Results The estimated diameters of Gd-G7 dendrimers were 11 ± 1 nm and those of Gd-G8

  14. Fibrous myopathy as a complication of repeated intramuscular injections for chronic headache

    Burnham, R.; McNeil, S; Hegedus, C; Gray, DS

    2006-01-01

    Two cases of fibrous myopathy associated with repeated, long-term intramuscular injections for treatment of chronic temporomandibular joint pain and chronic headache, respectively, are described. Both patients developed severe, function-limiting contractures in upper and lower extremity muscles used as injection sites. In one of the cases, the contractures were painful. Electrophysiological testing, magnetic resonance imaging and muscle biopsy results were all consistent with myopathy and rep...

  15. Solitary intramuscular myxoma with monostotic fibrous dysplasia as a rare variant of Mazabraud's syndrome

    The rare coexistence of intramuscular myxoma (IM) and fibrous dysplasia (FD) is known as Mazabraud's syndrome. IM tends to occur multifocally and is associated most frequently with polyostotic FD in Mazabraud's syndrome. We present an extremely rare combination of a solitary IM and monostotic FD as a variant of Mazabraud's syndrome, and discuss the importance of recognizing this rare coexistence for appropriate management of the patient. (orig.)

  16. Looking for the minimum efficiency of fibrous air filters during their service life

    Tronville, Paolo Maria

    2012-01-01

    Electret fibrous air filter media achieve high efficiencies while maintaining low air flow resistance by incorporating electrostatic charges on their fibers. However, captured ultrafine particles reduce this electrostatic enhancement. It is important to evaluate the behavior of such media when their electrostatic enhancement has been completely suppressed, leaving only "mechanical" effects such as sieving, impaction, interception and diffusion. Existing standards EN779:2002 and ASHRAE 52.2-20...

  17. Craniofacial fibrous dysplasia: Report of a case using computed tomographic scan diagnosis

    Nikhil Diwan; Mahesh Chavan; Anagha Shete; Shivaji Khedkar

    2013-01-01

    Fibro-osseous lesions are benign mesenchymal tumors in which mineralized tissue, blood vessels, and giant cells, in varying proportions, replace normal bone. Although this group of lesions includes reactive lesions, harmatomas, and neoplasms, they cannot be distinguished only on the basis of the histopathology which can only confirm their common fibro-osseous nature. Definitive diagnosis requires thorough radiological evaluation. Computed tomographic images of craniofacial fibrous dysplasia o...

  18. Self-Organized Criticality in a Model for Fracture on Fibrous Materials

    Bernardes, A; Moreira, J.

    1995-01-01

    We investigate the existence of self-organized criticality on a model to describe the failure process in fibrous materials. This model consists of identical parallel fibers which are pulled with constant velocity. The rupture probability of each fiber depends on the elastic energy of the fiber and on the number of unbroken neighboring fibers. In the brittle-ductile transition, we have observed a power law behaviour on the number of cracks versus its size. This indicates that, in this region, ...

  19. Single-Stage Complex Reconstruction for Fibrous Dysplasia: A Case Report

    Rosen, Charles L.; Sedney, Cara; Sivak, Jennifer

    2008-01-01

    Objective and Importance: Fibrous dysplasia is a benign skeletal condition which can involve the craniofacial skeleton. Surgery is indicated for correction of deformity and neurovascular decompression. Traditional surgery involves harvesting remote bone or calvarial grafts, requiring prolonged, multisite procedures. Custom implants may eliminate the need for bone harvesting, but usually require staged procedures with interim bony defects. We report the use of preoperative cranial modeling and...

  20. Non-standard test methods for long-fibrous reinforced composite materials

    L.A. Dobrzański; A. J. Nowak; Błażejewski, W.; R. Rybczyński

    2011-01-01

    Purpose: The investigations serve as comparative verification of silicone-aramid material designed for oesophageal prosthesis.Design/methodology/approach: In this work, non-standard research techniques, particularly designated for comparative tests of long-fibrous composite materials, are presented. Those tests are carried out on equipment similar to so called NOL rings test and pressure tests using rubber as a working mediumFindings: During interpretation of pressure tests results according ...

  1. Towards modelling of the frictional behaviour of deforming fibrous tows: A geometrical approach

    Cornelissen, Bo; Akkerman, Remko

    2010-01-01

    Fibrous tows used in continuous fibre-reinforced polymers (CFRPs) deform geometrically during the production of composite products. The cross-sectional geometry of the tow is influenced by the load-induced deformation mechanisms. A study of the effect of two commonly assumed geometrical tow shapes on an equivalent pressure distribution in a tow-on-a-pin spreading arrangement was performed. The preliminary results show that both elliptic and parabolic tow geometries have qualitatively the comp...

  2. Fibrous based materials in sustainable civil and architectural applications – a review

    Fangueiro, Raúl; Rosado, Katherine; Guise, Catarina; Rebelo, Rita

    2011-01-01

    The aim of this review paper is to present a survey on fibrous materials used in key areas of construction and architectural sectors. Here are highlighted conceptual challenges involved in some of the applications trying to define what we call a “green” building. The main applications reviewed are concrete reinforcement, structural health monitoring, insulation, and architectural membranes. On the other hand, tendencies in the area such as sustainability, weight reduction, enhanced durability...

  3. Fibrous Agricultural Biomass as a Potential Source for Bioconversion to Vanillic Acid

    Pei-Ling Tang; Osman Hassan; Jamaliah Md-Jahim; Wan Aida Wan Mustapha; Mohamad Yusof Maskat

    2014-01-01

    This study was conducted to assess the potential of six fibrous agricultural residues, namely, oil palm empty fruit bunch fiber (OPEFBF), coconut coir fiber (CCF), pineapple peel (PP), pineapple crown leaves (PCL), kenaf bast fiber (KBF), and kenaf core fiber (KCF), as a source of ferulic acid and phenolic compounds for bioconversion into vanillic acid. The raw samples were pretreated with organosolv (NaOH-glycerol) and alkaline treatment (NaOH), to produce phenol-rich black liquor. The findi...

  4. FINITE ELEMENT ANALYSIS OF SLURRY INFILTRATED FIBROUS CONCRETE TWO WAY SLABS SUBJECTED TO FLEXURAL LOADING

    Rajasekhar, K.; Dr.H.Sudarsana Rao; Dr. VAISHALI.G.GHORPADE

    2012-01-01

    Slurry Infiltrate Fibrous Concrete (SIFCON) is a new high performance and advanced material and can be considered as a special type of steel fiber reinforced concrete (SFRC). This paper describes the development of two – way slab model to predict the non-linear load-displacement behavior of SIFCON slab subjected to pressure loading. Slabs with 8%, 10% and 12% for different edge conditions have been modeled in Finite elements and verified with experimental values. The results of the analysis s...

  5. Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells

    Riminucci, Mara; Robey, Pamela Gehron; Saggio, Isabella; Bianco, Paolo

    2010-01-01

    Activating mutations of the GNAS gene, which causes fibrous dysplasia of bone (FD), lead to remarkable changes in the properties of skeletal progenitors, and it is these changes that mediate the pathological effect of this gene on bone. Mutated skeletal stem cells lose the ability to differentiate into adipocytes, and to maintain in situ, and transfer heterotopically, the hematopoietic microenvironment, leading to abnormal bone marrow histology in FD. They over-express molecular effectors of ...

  6. Conductive electrospun PANi-PEO/TiO{sub 2} fibrous membrane for photo catalysis

    Neubert, Sebastian [National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077 (Singapore); Pliszka, Damian, E-mail: nnidp@nus.edu.sg [National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077 (Singapore); Thavasi, Velmurugan [National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077 (Singapore); Wintermantel, Erich [Technical University of Munich, Bolzmannstr. 15, 85748 Garching (Germany); Ramakrishna, Seeram [National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077 (Singapore); King Saud University, Riyadh 11451 (Saudi Arabia)

    2011-05-15

    Graphical abstract: - Abstract: The integration of electrospinning and electrospraying to prepare the fibrous catalytic filter membrane is demonstrated. The non-conductive polyethylene oxide (PEO) is blended with ({+-})-camphor-10-sulfonic acid (CSA) doped conductive polyaniline (PANi) for electrospinning. The conductive CSA/PANi-PEO composite fibers are produced upon electrospinning, which are used as the conductive collector for electrospraying process by which titanium dioxide (TiO{sub 2}) nanoparticles (NPs) are sprayed and allowed to adsorb on the fibers. The degree of adsorption and dispersion of nano TiO{sub 2} catalysts on the surface of the CSA/PANi-PEO fibers exhibit a stronger dependence on weight percentage (wt%) of PANi in PEO solution and the strength of electrical conductivity of the fibers used during electrospraying. CSA/PANi-PEO fibers as collector reduce the wastage of TiO{sub 2} NPs during electrospraying to lesser than 5%. Among the three different composition of PANi studied, PEO with 12 wt% PANi yields very uniform diameter and beads-free fibrous structure with higher electrical conductivity. 12 wt% CSA/PANi-PEO fibrous membrane is found to support for greater dispersion of TiO{sub 2} NPs. The photocatalytic activity of the as-prepared TiO{sub 2}-PANi-PEO catalytic membrane is tested against the toxicant simulant 2-chloroethyl phenyl sulfide (CEPS) under the ultraviolet light irradiation. It is observed that the TiO{sub 2} nanoparticles catalysts embedded PANi-PEO fibrous membrane decontaminated the toxicant CEPS significantly, which is due to uniform dispersion of the catalysts produced by the methodology.

  7. Complexation of fibrous Tiopan-1 sorbent with cadmium(2), cobalt(2) zinc(2) ions

    Complex formation processing of functional groups of fibrous sulfur-nitrogen-containing adsorbent Tiopan-1 with cadmium ions are studied using potentiometry, IR-spectroscopy, as well as electron spectroscopy with diffusion reflection. Composition of forming complexes in adsorbent phase is established. Stability constants are determined in 0.096-1.92 ionic force interval of sodium chloride phone. Thermodynamic constants of stability are calculated

  8. Gene expression profiling of craniofacial fibrous dysplasia reveals ADAMTS2 overexpression as a potential marker

    Zhou, Shang-Hui; Yang, Wen-Jun; Liu, Sheng-Wen; Li, Jiang; Zhang, Chun-Ye; Zhu, Yun; ZHANG, CHEN-PING

    2014-01-01

    Fibrous dysplasia (FD) as an abnormal bone growth is one of the common fibro-osseous leasions (FOL) in oral and maxillofacial region, however, its etiology still remains unclear. Here, we performed gene expression profiling of FD using microarray analysis to explore the key molecule events in FD development, and develop potential diagnostic markers or therapeutic targets for FD. We found that 1,881 genes exhibited differential expression with more than two-fold changes in FD compared to norma...

  9. Cell Free Xanthan Gum Production Using Continuous Recycled Packed Fibrous-bed Bioreactor-membrane

    Rosalam, S.; Krishnaiah, D.; Bono, A.

    2008-01-01

    Although the xanthan gum has been produced as a commercial commodity, the biomass isolation and its recovery are still challenging. This study revealed the xanthan gum production by fermentation of Xanthomonas campestris DSMZ using glucose as a carbon source in an immobilised batch and a continuous recycled packed fibrous-bed bioreactor-membrane (CRPBFBM). The pure cotton fibre was used to immobilise the microbial cell biomass and to isolate from the liquid phase containing medium and xantha...

  10. Centrifugal spun ultrafine fibrous web as a potential drug delivery vehicle

    V. R. Giri Dev; L. Amalorpava Mary; T. Senthilram; SUGANYA, S.; Nagarajan, L; J. Venugopal; Ramakrishna, S.

    2013-01-01

    Centrifugal spinning (C-spin) is one of the emerging techniques for the production of ultrafine fibrous web which mimics Extracellular matrix (ECM). Due to its unique characteristic features it is widely used in bio-medical applications such as tissue engineered scaffolds, wound dressing materials and drug delivery vehicles. In the present study tetracycline loaded polycaprolactone (PCL) blended polyvinyl pyrrolidone (PVP) fibers were fabricated using in-house built C-spin system. The develop...

  11. Differentiation of benign and malignant skeletal lesions with quantitative diffusion weighted MRI at 3 T

    Ahlawat, Shivani, E-mail: sahlawa1@jhmi.edu [The Russell H. Morgan Department of Radiology & Radiological Science, The Johns Hopkins University School of Medicine, 601 North Wolfe Street, Baltimore MD 21287 (United States); Khandheria, Paras, E-mail: pkhandh1@jhmi.edu [The Russell H. Morgan Department of Radiology & Radiological Science, The Johns Hopkins University School of Medicine, 601 North Wolfe Street, Baltimore MD 21287 (United States); Subhawong, Ty K., E-mail: TSubhawong@med.miami.edu [Department of Radiology (R-109), University of Miami Leonard M. Miller Miami, FL 33101 (United States); Fayad, Laura M., E-mail: lfayad1@jhmi.edu [The Russell H. Morgan Department of Radiology & Radiological Science, The Johns Hopkins University School of Medicine, 601 North Wolfe Street, Baltimore MD 21287 (United States)

    2015-06-15

    Highlights: • DWI may have predictive value for the characterization of bone lesions. • Benign lesions have higher minimum, and mean ADC values than malignancies. • Minimum ADC has the highest accuracy in discerning benign from malignant lesion. • Minimum ADC of 0.9 × 10. • All ADC measurements were made with high inter-observer concordance. - Abstract: Objectives: To investigate the accuracy of quantitative diffusion-weighted imaging with apparent diffusion coefficient (ADC) mapping for characterizing bone lesions as benign or malignant. Methods: At 3 T, 31 subjects with intramedullary lesions imaged by DWI (b-values 50, 400, 800 s/mm{sup 2}) were included. ADC values (minimum, mean, maximum) were recorded by three observers independently. Interobserver variability and differences between ADC values in benign and malignant lesions were assessed (unpaired t-test, receiver operating characteristic (ROC) analysis). Results: Of 31 lesions, 18 were benign (osteoblastic (n = 1), chondroid (n = 6), cysts (n = 4), hemangiomatosis (n = 1), fibrous (n = 3), eosinophilic granuloma (n = 1), giant cell tumor (n = 1), osteomyelitis (n = 1)) and 13 were malignant (primary (n = 5), metastases (n = 8)). Overall, there were higher minimum (1.27 × 10{sup −3} mm{sup 2}/s vs 0.68 × 10{sup −3} mm{sup 2}/s, p < 0.001), mean (1.68 × 10{sup −3} mm{sup 2}/s vs 1.13 × 10{sup −3} mm{sup 2}/s, p < 0.001), and maximum (2.09 × 10{sup −3} mm{sup 2}/s vs 1. 7 × 10{sup −3} mm{sup 2}/s, p = 0.03). ADC values in benign lesions compared with those in malignancies. ROC analysis revealed areas under the curve for minimum, mean, and maximum ADC values of 0.91, 0.85, and 0.71, respectively. ADC measurements were made with high inter-observer concordance (ρ = 0.83–0.96). Conclusion: Quantitative ADC maps may have predictive value for the characterization of bone lesions. Benign lesions generally have higher minimum, mean, and maximum ADC values than malignancies, with the

  12. Differentiation of benign and malignant skeletal lesions with quantitative diffusion weighted MRI at 3 T

    Highlights: • DWI may have predictive value for the characterization of bone lesions. • Benign lesions have higher minimum, and mean ADC values than malignancies. • Minimum ADC has the highest accuracy in discerning benign from malignant lesion. • Minimum ADC of 0.9 × 10. • All ADC measurements were made with high inter-observer concordance. - Abstract: Objectives: To investigate the accuracy of quantitative diffusion-weighted imaging with apparent diffusion coefficient (ADC) mapping for characterizing bone lesions as benign or malignant. Methods: At 3 T, 31 subjects with intramedullary lesions imaged by DWI (b-values 50, 400, 800 s/mm2) were included. ADC values (minimum, mean, maximum) were recorded by three observers independently. Interobserver variability and differences between ADC values in benign and malignant lesions were assessed (unpaired t-test, receiver operating characteristic (ROC) analysis). Results: Of 31 lesions, 18 were benign (osteoblastic (n = 1), chondroid (n = 6), cysts (n = 4), hemangiomatosis (n = 1), fibrous (n = 3), eosinophilic granuloma (n = 1), giant cell tumor (n = 1), osteomyelitis (n = 1)) and 13 were malignant (primary (n = 5), metastases (n = 8)). Overall, there were higher minimum (1.27 × 10−3 mm2/s vs 0.68 × 10−3 mm2/s, p < 0.001), mean (1.68 × 10−3 mm2/s vs 1.13 × 10−3 mm2/s, p < 0.001), and maximum (2.09 × 10−3 mm2/s vs 1. 7 × 10−3 mm2/s, p = 0.03). ADC values in benign lesions compared with those in malignancies. ROC analysis revealed areas under the curve for minimum, mean, and maximum ADC values of 0.91, 0.85, and 0.71, respectively. ADC measurements were made with high inter-observer concordance (ρ = 0.83–0.96). Conclusion: Quantitative ADC maps may have predictive value for the characterization of bone lesions. Benign lesions generally have higher minimum, mean, and maximum ADC values than malignancies, with the minimum value offering the highest accuracy for characterization

  13. Two stage reconstruction for the Shepherd′s crook deformity in a case of polyostotic fibrous dysplasia.

    Nagda T

    1997-07-01

    Full Text Available Polyostotic fibrous dysplasia leads to progressive and disabling deformity involving the proximal femur. Conventional methods of treatment have been ineffective in controlling this problem. Two stage reconstruction was carried out in a case of polyostotic fibrous dysplasia with bilateral shepherd′s crook deformity. Bilateral subtrochanteric osteotomies with intramedullary fixation in the first stage and intertrochanteric osteotomies in the second stage with nail plate fixation was done to provide definitive control of the deformity. Bone graft was not used.

  14. Calculation software for efficiency and penetration of a fibrous filter medium based on the mathematical models of air filtration

    Kouropoulos, Giorgos

    2014-01-01

    At this article will be created a software written in visual basic for efficiency and penetration calculation in a fibrous filter medium for given values of particles diameter that are retained in the filter. Initially, will become report of mathematical models of air filtration in fibrous filters media and then will develop the code and the graphical interface of application, that are the base for software creation in the visual basic platform.

  15. Hierarchical Micro- and Nanostructured Superhydrophobic Surfaces to Reduce Fibrous Encapsulation of Pacemaker Leads : Nanotechnology in Practical Applications

    Carlsson, Louise

    2008-01-01

    The purpose of this master’s thesis was to, by the use of nanotechnology, improve material properties of the biomedical polymer Optim™, used as the insulation of pacemaker leads. Improved material properties are required to reduce the extent of fibrous encapsulation of the leads. Today, laser ablation is used to be able to remove the pacemaker lead because of the fibrous tissue, which can cause the lead to adhere to vascular structures. Consequently, the laser ablation results in risks of dam...

  16. STRENGTH AND DEFORMABILITY OF STRUCTURAL ELEMENTS OF TRANSPORT FACILITIES ON THE BASIS OF FINE-GRAINED FIBROUS STEEL SLAG CONCRETE

    R. N. Chernousov; V. A. Kozlov; B. A. Bondarev

    2011-01-01

    Problem statement. Application of steel fibrous concrete in structures of transport facilities providesfor their reliable and durable operation, however, along with the indisputable advantages,steel fibrous concrete has significant drawback. Its application in transport construction is very expensive.The use of cast slag crushed stone screenings, along with fibers from waste products oflocal factories, as a filler of concrete matrix will significantly reduce the costs of production oftranspor...

  17. Bionic electrospun ultrafine fibrous poly(L-lactic acid) scaffolds with a multi-scale structure

    Poly(L-lactic acid) (PLLA) tissue engineering scaffolds with porous inner structures of individual fibers and controllable architectures were successfully fabricated from the homogeneous polymer-solvent-nonsolvent system (PLLA, CH2Cl2 and DMF) by a single capillary electrospinning with certain conductive patterned templates as fiber collectors. PLLA was dissolved in dimethylformamide (DMF) and methylene chloride (CH2Cl2) mixed solvent with different ratios. Semi-hollow fiber with porous inner structure and compact shell wall was formed by controlling the content of DMF in the mixed solvents. It is believed that the phase separation should be the key origin for the formation of this microstructure. In order to mimic the natural extracellular matrix (ECM) with a specific structure, conductive patterned collectors were designed and employed to manufacture PLLA ultrafine fibrous scaffolds with three-dimensional architectures. We believe these kinds of multi-scale biodegradable fibrous scaffolds with specific microstructure and macro-architectures could make the electrospun fibrous scaffold better mimic the natural extracellular matrix to satisfy tissue engineering.

  18. Cellulose nanocrystal-filled poly(acrylic acid) nanocomposite fibrous membranes

    Lu, Ping; Hsieh, You-Lo

    2009-10-01

    Nanocomposite fibrous membranes have been fabricated by electrospinning cellulose nanocrystal (CNC)-loaded poly(acrylic acid) (PAA) ethanol mixtures. Incorporating CNC in PAA significantly reduced fiber diameters and improved fiber uniformity. The average diameters of the as-spun nanocomposite fibers were significantly reduced from 349 nm to 162 nm, 141 nm, 90 nm and 69 nm at 5%, 10%, 15% and 20% CNC loading (by weight of a constant 4% PAA solution), respectively. CNC was well dispersed in the fibers as isolated rods oriented along the fiber axis and as spheres in the PAA matrix. The Young modulus and stress of the PAA/CNC nanocomposite fibers were significantly improved with increasing CNC loadings by up to 35-fold and 16-fold, respectively. Heat-induced esterification between the CNC surface hydroxyls and PAA carboxyl groups produced covalent crosslinks at the CNC-PAA interfaces, rendering the nanocomposite fibrous membranes insoluble in water, more thermally stable and far more superior in tensile strength. With 20% CNC, the crosslinked nanocomposite fibrous membrane exhibited a very impressive 77-fold increase in modulus and 58-fold increase in stress.

  19. Cellulose nanocrystal-filled poly(acrylic acid) nanocomposite fibrous membranes

    Nanocomposite fibrous membranes have been fabricated by electrospinning cellulose nanocrystal (CNC)-loaded poly(acrylic acid) (PAA) ethanol mixtures. Incorporating CNC in PAA significantly reduced fiber diameters and improved fiber uniformity. The average diameters of the as-spun nanocomposite fibers were significantly reduced from 349 nm to 162 nm, 141 nm, 90 nm and 69 nm at 5%, 10%, 15% and 20% CNC loading (by weight of a constant 4% PAA solution), respectively. CNC was well dispersed in the fibers as isolated rods oriented along the fiber axis and as spheres in the PAA matrix. The Young modulus and stress of the PAA/CNC nanocomposite fibers were significantly improved with increasing CNC loadings by up to 35-fold and 16-fold, respectively. Heat-induced esterification between the CNC surface hydroxyls and PAA carboxyl groups produced covalent crosslinks at the CNC-PAA interfaces, rendering the nanocomposite fibrous membranes insoluble in water, more thermally stable and far more superior in tensile strength. With 20% CNC, the crosslinked nanocomposite fibrous membrane exhibited a very impressive 77-fold increase in modulus and 58-fold increase in stress.

  20. The Philippines [Status and technology of polymer-containing fibrous materials in the Eastern Hemisphere

    Fibrous materials (timber and fibres) constitute one of the most steady dollar-earning industries in the Philippines. In 1966 the produce from this industry alone was worth 1061 million pesos, which was almost 6% of the country's national income. The total timber production amounted to 3 325 541 899 board feet, of which 15. 2% was consumed locally and the rest exported to different countries, with Japan as one of the largest importers. The Philippines produces quite a number of varieties of timber and fibre which have earned a good reputation for quality in the world market. However, there are also other varieties of timber and fibres which need improvement to gain a market. Plastic impregnation of these fibrous materials seems a very promising technique for improving their quality. Plastic impregnation of fibrous materials, being a relatively new field, has only recently been started in the Philippines. So far, only the Philippine Atomic Research Center (PARC) has been working in this field. Exploratory studies were initiated in November 1966. Initial work was confined to wood plastic combination (WPC)