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1

Postirradiation malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

An 80-year-old Japanese woman presented a severely painful tumor on the right side of the neck. The area had been treated with radiation under a diagnosis of lymphadenitis colli tuberculosa 50 years before and then with radiation for swelling on the same site (details of the condition and the dosage of radiation were not available) for a period of one year 15 years previously. A diagnosis of postirradiation malignant fibrous histiocytoma was made. Surgery and cryosurgery were not effective and the patient died about 6 months later. A review of 25 cases of postirradiation sarcoma was made. (author)

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Cutaneous metastatic malignant fibrous histiocytoma.  

Science.gov (United States)

Malignant fibrous histiocytoma is the most common soft tissue sarcoma, but cutaneous metastasis of this tumor is quite rare. A 30-year-old female patient had several brownish 0.5 x 0.5-cm papules on her right ankle. Histopathologic examination revealed spindle-shaped tumor cells with cellular pleomorphism and high mitosis (5 of 10 high-power fields), suggestive of malignant fibrous histiocytoma. She had a history of left subcutaneous breast mass that was diagnosed as malignant fibrous histiocytoma 3 years earlier. We report a case of malignant fibrous histiocytoma with pleomorphism mixed with spindle-shaped cells and multinuclear giant cells, which metastasized to the skin. PMID:12582384

Lew, Wook; Lim, Ha Seong; Kim, You Chan

2003-02-01

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Malignant fibrous histiocytoma with skeletal involvement  

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Full Text Available Malignant fibrous histiocytoma of soft part is rather common but malignant fibrous histiocytoma of the bone is rarely encountered clinically. Authors present five cases of malignant fibrous histiocytoma with skeletal involvement and discuss their clinical course, x-ray findings and histological features. This tumor has marked tendency for local recurrence and metastasis. Other bone tumors such as giant cell tumor, aneurysmal bone cyst, non ossifying fibroma, osteosarcoma, fibrosarcoma of bone and metastatic cancer can be excluded by several characteristic findings observed in x-rays as well as histopathological features. All information on the patient should be carefully analysed, because it is difficult to decide whether bone involvement is primary or secondary. Four out of five cases definitely originated within the bone.

Takechi,Hideo

1978-10-01

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Malignant fibrous histiocytoma of the spleen  

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Full Text Available Introduction. Since the first description of primary splenic malignant fibrous histiocytoma given by Govoni et al. in 1982, there have been only 18 reported cases by the end of 2013. We herein reported a case of rare primary malignant fibrous histiocytoma of the spleen with liver metastases and unspecific general symptoms. Case Report. A 62-year-old cachectic female complained of sharp strong abdominal pain (on the pain scale 8/10 and distaste for food on admission at Primary Care Service on March 29, 2014. On physical examination, palpable painful 2 cm long tumefact in the left hypochondriac segment was found. Laboratory findings showed leukocytosis 17.9 x 109/l, erythrocyte sedimentation rate of 55 mm/h, C reactive protein 25.8. Magnetic resonance of abdomen proved secondary deposits in the right liver segment and lower pole of spleen. Positron emission tomography-computed tomography recorded a cold necrosis field in the right liver part and lobulated cystic formation of spleen. After radiological examination, splenectomy and resection of the pancreas cauda were performed. Primary malignant splenic fibrous histiocytoma with liver metastases was proved histopathologically. The patient was given three chemotherapeutic series until October 2, 2014 and she is now in good general condition. Conclusion. The possibility of primary malignant splenic fibrous histiocytoma should be considered in every case with proved intra-abdominal masses of unknown origin. Clinical and laboratory findings are unspecific. Surgical resection with histopathological evaluation is the most effective diagnostic and therapeutic procedure.

Šipovac Dragana

2014-01-01

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Malignant fibrous histiocytoma in chordoma--immunohistochemical evidence of transformation from chordoma to malignant fibrous histiocytoma.  

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Sarcomatous transformation in chordoma (dedifferentiated chordoma) is a very rare condition and has been emphasized as a distinct entity because of its more aggressive clinical course. Here we describe a case of dedifferentiated chordoma (chordoma associated with malignant fibrous histiocytoma) arising from the sacrococcygeal region of a 55-year-old woman. The results of immunohistochemical stain in the chordoma area were strong positive for cytokeratin, epithelial membrane antigen and S-100 protein. The spindle and giant cells in the transitional areas of chordoma and malignant fibrous histiocytoma were positive for cytokeratin and epithelial membrane antigen in addition to vimentin and alpha-1-antichymotrypsin. The spindle and giant cells in the central area of malignant fibrous histiocytoma were negative for cytokeratin and epithelial membrane antigen, but positive for vimentin and alpha-1-antichymotrypsin. This supports the pathogenesis of sarcomatous transformation from chordoma. PMID:8091802

Choi, Y J; Kim, T S

1994-06-01

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Postirradiation sarcoma (malignant fibrous histiocytoma) following cervix cancer  

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A case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 11 years following postoperative external beam radiation therapy (7,000 rad) for carcinoma of the cervix. Reports of postirradiation malignant fibrous histiocytoma are rare, and the occurrence of this neoplasm following treatment for cervix cancer has not previously been described. The literature concerning postirradiation bone and soft tissue sarcomas is briefly reviewed, with special attention to malignant fibrous histiocytomas. (author)

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Imaging of soft tissue malignant fibrous histiocytoma  

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Malignant fibrous histiocytoma (MFH) is a rare and potentially highly malignant sarcoma. The authors report 6 cases of MFH in various sites : two in the chest wall, one in the pelvis, two in the gluteal zones and one on the scalp. Ultrasonography and computed tomography were the main imaging methods used in the assessment of the structure and extension of the tumor. A poor prognosis was noted in four cases: death within a few months in the two thoracic sites, recurrence in the pelvic and scalp lesions, radical surgery allowed recovery in two cases. A review of the literature showed that MRI and CT are complementary in the initial staging and follow-up these patients. (author)

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The gallium scan in malignant fibrous histiocytoma  

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Soft tissue sarcoma is a relatively uncommon malignancy. Of its various histological types, malignant fibrous histiocytoma is most common and usually is seen in late adult life affecting primarily extremities and trunk with or without bony involvement. Before undertaking potentially toxic treatments with chemotherapeutic agents, tumor aggressiveness must be estimated. The authors use /sup 67/Ga citrate to supplement other imaging modalities to measure size, location and extent prior to and during treatment. In all, 22 consecutive patients were studied, with 13 males and 9 females. The median age was 43 (range 15 to 68) with majority of patients in 4th to 6th decades. Extremity lesions were present in 18, pelvic in 1, thoracic in 2, and abdominal in 1. Eighteen patients were studied shortly after the diagnosis and 4 during their recurrences. In the 18 patients with primary tumor, 12 showed marked increased uptake in the region of tumor, or increased uptake in soft tissues with a distribution different from the changes noted in the MDP bone scan. In 4 patients with extremity lesions, abnormalities were seen in Ga but were not definite in MDP bone scans. Four patients had tumor recurrences following surgery, radiation therapy or chemotherapy. High Ga uptake was found in the regions of recurrent tumor in 2 and in the lung metastases of another. Interval changes were more easily appreciated in the Ga scan than in the MDP bone scan. Information obtained from Ga images provides additional clues in determining extent of soft tissue involvement and assists in monitoring therapeutic responses.

Yeh, S.D.J.; Rosen, G.; Benua, R.S.

1984-01-01

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The gallium scan in malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Soft tissue sarcoma is a relatively uncommon malignancy. Of its various histological types, malignant fibrous histiocytoma is most common and usually is seen in late adult life affecting primarily extremities and trunk with or without bony involvement. Before undertaking potentially toxic treatments with chemotherapeutic agents, tumor aggressiveness must be estimated. The authors use /sup 67/Ga citrate to supplement other imaging modalities to measure size, location and extent prior to and during treatment. In all, 22 consecutive patients were studied, with 13 males and 9 females. The median age was 43 (range 15 to 68) with majority of patients in 4th to 6th decades. Extremity lesions were present in 18, pelvic in 1, thoracic in 2, and abdominal in 1. Eighteen patients were studied shortly after the diagnosis and 4 during their recurrences. In the 18 patients with primary tumor, 12 showed marked increased uptake in the region of tumor, or increased uptake in soft tissues with a distribution different from the changes noted in the MDP bone scan. In 4 patients with extremity lesions, abnormalities were seen in Ga but were not definite in MDP bone scans. Four patients had tumor recurrences following surgery, radiation therapy or chemotherapy. High Ga uptake was found in the regions of recurrent tumor in 2 and in the lung metastases of another. Interval changes were more easily appreciated in the Ga scan than in the MDP bone scan. Information obtained from Ga images provides additional clues in determining extent of soft tissue involvement and assists in monitoring therapeutic responses

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Malignant fibrous histiocytoma of rectum: Report of a case  

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Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma of adults, mostly distributed in the thigh, buttock and groin (46%) and presents rarely in the gastrointestinal tract, classified as gastrointestinal stromal tumors (GIST). MFH is regarded as a diagnosis of exclusion, essentially synonymous with an undifferentiated pleomorphic sarcoma. The recent report presents an 80-year-old man with clinical manifestations of rectal bleeding and final diagnosis of MFH of rectum. It...

Azizi, Rasoul; Mahjoubi, Bahar; Shayanfar, Nasrin; Anaraki, Fakhryalsadat; Zahedi-shoolami, Leila

2011-01-01

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Metastasized malignant fibrous histiocytoma as a cause of gastrointestinal tract haemorrhage.  

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Malignant fibrous histiocytoma (MFH) is the most frequently diagnosed soft-tissue tumour in adults. Many patients have metastases already at diagnosis. Bleeding metastases in the gastrointestinal tract are very rare. We present what we believe to be the first reported case of bleeding metastasis from a malignant fibrous histiocytoma of the small bowel. PMID:9438328

Blaauwwiekel, E E; Koopal, S; Kreeftenberg, H G

1997-12-01

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Malignant fibrous histiocytoma of the lower lip: A case report  

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Full Text Available Malignant fibrous histiocytoma (MFH represents the diagnosis that is still commonly used by both patients and physicians although in 2002., the World Health Organization (WHO declassified MFH as a formal diagnostic entity, renaming it as an undifferentiated pleomorphic sarcoma not specifying it further. MFH is extremely rare in the oral cavity. The aim of this article was to describe a newly diagnosed case of primary MFH in a 78-year-old male presented after 4-months history of rapidly increasing swelling of lower lip. Histopathology of the lesion showed highly malignant cell infiltration with epithelioid/spindle cell type morphology. Immunohistochemical study was positive for vimentin (++, S-100 protein (++ and negative for desmin and cytokeratin. The authors discussed the possibilities of immunohistochemical study and necessity of individual treatment plan in patients with MFH, comparing their point of view with other studies.

Pechalova Petia F

2012-01-01

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Case report 505: Malignant fibrous histiocytoma of thigh and liposarcoma in same lower extremity (synchronous lesions)  

International Nuclear Information System (INIS)

CT plays a valuable role in the preoperative evaluation of sarcoma of soft tissues. The present report reveals the radiological and pathological features of malignant fibrous histiocytoma and liposarcoma - lesions which appear in the same patient. (orig./GDG)

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Histiocitoma fibroso maligno / Histiocytome fibreux malin / Malignant fibrous histiocytoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: los sarcomas son tumores malignos de partes blandas que representan 0,7 % de los tumores malignos en general, con una tasa de 3 por cada 100 000. El histiocitoma fibroso maligno resulta un tumor de alto grado incluido en el grupo de los sarcomas de partes blandas. Objetivo: exponer las [...] características citohistológicas, el tratamiento y la evolución de este tumor en un caso estudiado y tratado en el Hospital General Provincial Docente "Roberto Rodríguez Fernández" de Ciego de Ávila. Descripción: se presentó el caso de un varón de 60 años con una gran masa de partes blandas en el muslo izquierdo, de crecimiento progresivo. La masa se trató quirúrgicamente con exéresis en bloque, previos estudios analíticos, arteriografía femoral y ecografía. Conclusiones: el diagnóstico anatomopatológico fue de histiocitoma fibroso maligno variedad pleomórfica; fue remitido al servicio de oncología donde lo trataron con radioterapia. A los 6 meses se encontraba libre de la enfermedad. Se realizó una revisión de la literatura y se analizó su presentación clínica, también los hallazgos histológicos, las pruebas diagnósticas de imagen y el procedimiento terapéutico. Abstract in english Introduction: the sarcomas are soft tissue malignant tumors accounting for the 0.7 % of malignant tumors in general with a rate of 3 by 100 000. The malignant fibrous histiocytoma is a high grade tumor included in the group of soft tissue tumors. Objective: to expose the cytohistologic features, tre [...] atment and course of this tumor in study case and treated in "Roberto Rodríguez Fernández" Teaching Provincial Hospital of Ciego de Avila municipality. Description: this is the case of a male patient aged 60 presenting with an increasing large soft tissue mass in the left thigh. The mass was operated on with block exeresis, analytical previous studies, femoral arteriography and echography. Conclusions: the anatomic and pathologic diagnosis was a malignant fibrous histiocytoma pleomorphous type; the patient was referred to Oncology service where was treated with radiotherapy. At 6 months he was free of disease. A review of literature was performed analyzing its clinical presentation also, its histological findings, the imaging diagnostic test and the therapeutical procedure.

Hiralio, Collazo Álvarez; Dewar, Torrecilla Silverio; Jorge Luis, Morales Florat; Stephens Yecc, Collazo Marín.

2012-06-01

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Malignant fibrous histiocytoma of the mandible and the infratemporal fossa—A case report  

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Malignant fibrous histiocytoma is a sarcoma which commonly occurs in the soft tissues, joints and tendons of the extremities of adults but its occurrence in the oral and maxillofacial region is very rare. We present a rare case of malignant fibrous histiocytoma of the mandible with recurrence in the infratemporal fossa after surgery and radiotherapy. Patient underwent second surgery and complete tumor excision with minimal loss of function was achieved. Patient survived 8 years after surgery ...

Joshi, Himani; Rayappa, Chinna Swamy

2011-01-01

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MALIGNANT FIBROUS HISTIOCYTOMA OF THE PENIS A CASE REPORT AND REVIEW OF THE LITERATURE  

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Full Text Available Penile malignant fibrous histiocytoma is an extremely rare tumor. To the best of our knowledge, we present here the fifth primary malignant fibrous histiocytoma of the penis. The patient presented with lung metastasis which initially responded well to systemic chemotherapy with Adriamycin and Ifosfamide, but recurred soon after. The local lesion did not respond to chemotherapy and the patient had to undergo a palliative penectomy. The disease progressed rapidly and the patient died one year after the diagnosis.

Tufan Tarcan

2009-01-01

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Malignant fibrous histiocytoma in rats at sites of implanted millipore filters.  

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Soft-tissue tumors developing in rats at the site of implanted Millipore filters showed the structural, cytochemical, and biologic characteristics of the malignant fibrous histiocytomas occurring in man. Evidence from this tumor model suggests that malignant fibrous histiocytomas can arise from pluripotential mesenchymal stem cells which are not derived from the mononuclear/phagocytic system and that chronic inflammation and scarring may predispose to their development.

Greaves, P.; Martin, J. M.; Rabemampianina, Y.

1985-01-01

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Malignant fibrous histiocytoma of sternum: an unusual cause of pyrexia of undetermined origin.  

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Malignant fibrous histiocytoma of the bone is a very rare tumour mainly affecting long bones, and the most common presenting symptom is local pain. A case of malignant fibrous histiocytoma presenting with pyrexia of undetermined origin and arising in the sternum, a localization not previously described, is reported. The patient died with septic shock after multi-drug chemotherapy including high dose methotrexate treatment with citrovorum factor rescue.

Grieco, A.; Caputo, S.; Silvestri, E.; Caradonna, P.; Bertoli, A.; Greco, A. V.

1989-01-01

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Postirradiation sarcoma (malignant fibrous histiocytoma) following uterine cervical cancer  

International Nuclear Information System (INIS)

A case of postirradiation sarcoma, a malignant fibrous histiocytoma, is described. The tumor occurred in the radiation field (the buttock) 8 years after radiation therapy for keratinizing squamous cell carcinoma of the uterine cervix. The 68-year-old female patient with the inital diagnosis of cervical cancer was treated with pelvic irradiation in 1973. She did well after that with no evidence of disease until 1981 when she developed an enlarging mass in the right buttock within the field of the previous radiation therapy. Microscopically, the tumor at biopsy was composed of pleomorphic histiocyte-like cells, spindle-sphaped cells arranged in a storiform pattern and multinucleated giant cells with bizarre nuclei. Cytodiagnostically, two types of cells, fibroblast-like cells ane histiocyte-like cells, were found. And some cells were considered to be transitional forms, intermediate between fibroblast and histiocytes. Multinucleated pleomorphic giant cells were sometimes seen. Ultrastructurally, the same types of cells were confirmed. These cells contained large numbers of rough endoplasmic reticula with dilated lumens, vacuoles, lysosomal structures, and lipid droplets. (author)

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Radiation-induced malignant fibrous histiocytoma of the maxilla.  

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Malignant fibrous histiocytoma (MFH) originates from primitive mesenchymal cells and has the capacity for dual histiocytic and fibroblastic differentiation. We report on an MFH of the left maxilla that developed in a 79-year old woman 20 years after surgery and radiation for squamous cell carcinoma (SCC). Postoperative radiotherapy with 70 Gy was administered for a primary neoplasm of SCC of the left maxilla to a localized field through two lateral ports. This secondary neoplasm arose at the site of tumor resection (partial maxillectomy) within the irradiated field, and was resected. The development of sarcomas is a recognized complication of radiation therapy. The final diagnosis after the operation was MFH. The patient died of tumor recurrence at the skull base and within the cranium, 19 months after the operation. Radiation-induced sarcoma is well known, but radiation-induced MFH is relatively rare in the head and neck region. The details of this case are presented with a review of literature. PMID:21487703

Satomi, Takafumi; Watanabe, Masato; Kaneko, Tadayoshi; Matsubayashi, Jun; Nagao, Toshitaka; Chiba, Hiroshige

2011-07-01

 
 
 
 
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An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report  

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Full Text Available Abstract Introduction Malignant fibrous histiocytoma is a very common subtype of soft-tissue sarcoma in middle and late adulthood. However, malignant fibrous histiocytoma of the testis is very rare in adolescents. Case presentation We report here the case of a 14-year-old Han Chinese boy, who presented with left scrotal mass lasting for 20 days along with distending pain for 5 days. A physical examination revealed a chicken egg-sized, firm, well-defined mass and unclear epididymis. A B-scan ultrasonography of the left scrotum displayed a 9.0×5.2×4.5cm medium- or low-echoic lobulated mass, which suggested a left testicular neoplasm. A fine needle aspiration cytology examination revealed that the cells obtained from the patient’s testicular neoplasm were composed of myxoid spindle, and ovoid cells with nuclear atypia and mitotic activity, and arranged in a whirlpool or storiform pattern. Under histological examination, the tumor cells were arranged in a storiform pattern, which displayed mucoid matrix degeneration, and grew invasively. Consequently, a histopathological diagnosis suggested myxofibrosarcoma (or myxoid malignant fibrous histiocytoma. Conclusions An ultrasonic examination combined with fine needle aspiration cytology should be helpful for the initial differential diagnosis of testicular malignant fibrous histiocytoma. However, the final confirmation relies on histopathological examination. To the best of our knowledge, this is the first reported case of malignant fibrous histiocytoma of the testis in an adolescent.

Wang Lian-Li

2013-01-01

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Postirradiation malignant fibrous histiocytoma expressing cytokeratin. Implications for the immunodiagnosis of sarcomas  

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A malignant fibrous histiocytoma of the sacrum complicating the course of radiation therapy for endometrial carcinoma is presented. Although the tumor fulfilled the clinical, radiologic, and histologic criteria for a postirradiation malignant fibrous histiocytoma of bone, it also expressed cytokeratin. That this immunoreactivity reflected keratin synthesis by the tumor and not an unusual pattern of cross-reactivity with another intermediate filament such as vimentin is strongly suggested by the reproducibility of the immunoreactivity utilizing both polyclonal and monoclonal antibodies and extinction of the immunoreactivity following absorption of the primary antiserum with keratin proteins. This is the first reported instance of keratin expression by a malignant fibrous histiocytoma; it indicates that sarcomas apart from synovial sarcoma and epithelioid sarcoma may sometimes express this protein.

Weiss, S.W.; Bratthauer, G.L.; Morris, P.A.

1988-07-01

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Postirradiation malignant fibrous histiocytoma expressing cytokeratin. Implications for the immunodiagnosis of sarcomas  

International Nuclear Information System (INIS)

A malignant fibrous histiocytoma of the sacrum complicating the course of radiation therapy for endometrial carcinoma is presented. Although the tumor fulfilled the clinical, radiologic, and histologic criteria for a postirradiation malignant fibrous histiocytoma of bone, it also expressed cytokeratin. That this immunoreactivity reflected keratin synthesis by the tumor and not an unusual pattern of cross-reactivity with another intermediate filament such as vimentin is strongly suggested by the reproducibility of the immunoreactivity utilizing both polyclonal and monoclonal antibodies and extinction of the immunoreactivity following absorption of the primary antiserum with keratin proteins. This is the first reported instance of keratin expression by a malignant fibrous histiocytoma; it indicates that sarcomas apart from synovial sarcoma and epithelioid sarcoma may sometimes express this protein

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Malignant fibrous histiocytomas and H-ras-1 oncogene point mutations.  

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AIMS: To investigate the types and the frequencies of H-ras-1 gene mutations in malignant fibrous histiocytomas. METHODS: Thirty five samples of malignant fibrous histiocytoma tissue were searched for point mutations within "hot spot" codons 12 and 13 of the H-ras-1 oncogene by the specific "nested" polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) and a direct cycle sequencing procedure. RESULTS: In contrast to previous reports, none of the tumours contained a point mutation or any other changes within or around the hot spot gene sequences. CONCLUSIONS: These data indicate that H-ras-1 oncogenic activation is not required in the molecular pathway of malignant fibrous histiocytoma formation and cannot be used as a discriminating factor for diagnostic sarcoma typing. PMID:10474683

Rieske, P; Bartkowiak, J; Szadowska, A; Debiec-Rychter, M

1999-01-01

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Malignant fibrous histiocytoma: a retrospective study of 109 cases.  

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The purpose of this report is to assess the prognostic factors that could influence management and clinical outcome of malignant fibrous histiocytoma (MFH) of soft tissues. Between 1975 and 1998, 109 patients diagnosed with MFH of the soft tissues, seen at King Faisal Specialist Hospital and Research Center, have been reviewed. Of the 109 patients, 75 were men and 34 were women. The median age at presentation was 48 years (range: 3-94). Seven patients (6%) had regional nodal disease and 10 other patients (9%) with distant metastases were excluded from survival analysis. The remaining 92 patients had localized disease and had surgery as the primary treatment modality with or without radiotherapy and/or chemotherapy. Extremities were the most common location (58%). Tumors less than 5 cm represented 32%, whereas 68% had tumors 5 cm or more. Low-grade tumors constituted 46%, and the remaining 54% were high grade. Thirty-seven percent of patients had positive surgical margins histologically after complete gross resection. The 5- and 10-year relapse-free survival (RFS) rates were 39% and 36%, respectively. Isolated local recurrence occurred in 20 patients (22%), isolated metastatic disease without local recurrence in 9 patients (10%), and combined local and metastatic disease occurred in 20 patients (22%). The overall 5- and 10-year overall survival (OS) rates were 50% and 43%, respectively. On multivariate analysis, tumor size and radiation dose were significant factors for RFS (p = 0.04 and 0.0005, respectively). In terms of OS, size, histologic grade, and surgical margins were significant factors on multivariate analysis (p = 0.001. 0.006, and 0.0001, respectively). Complete surgical resection at the time of primary tumor presentation is likely to afford the best chance for RFS and OS. Radiation therapy plays an important role, in combination with surgery for better local control, particularly in high-grade lesions, and in cases with positive surgical margins after wide complete gross excision. The role of adjuvant chemotherapy remains investigational. PMID:11823689

Belal, Abdelaziz; Kandil, Alaa; Allam, Ayman; Khafaga, Yasser; El-Husseiny, Gamal; El-Enbaby, Ashraf; Memon, Mohamed; Younge, Derek; Moreau, Paul; Gray, Alan; Schultz, Henrik

2002-02-01

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Rare type of bladder cancer: malign fibrous histiocytoma.  

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Malignant fibrous histocytoma (MFH) is the most common soft tissue sarcoma in adults. Urinary tract is a very rare location for MFH. Involvement of the bladder is more common in males and at the 6th decade of life. A case of MFH of the bladder with poor prognosis is presented. Prognostic factors for MFH are tumor grade, amount of invasion, age, tumor size, and histological type. Survival rate is very low and 3-year disease specific survival is approximately 40%. PMID:25017607

Celik, Orcun; Turk, Hakan; Budak, Salih; Ilbey, Yusuf Ozlem

2014-06-01

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Primary Giant Cell Malignant Fibrous Histiocytoma of the Kidney with Staghorn Calculi  

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Full Text Available Malignant fibrous histiocytomas (MFH as primary renal tumours are rare, with less than 50 cases described in the literature. We report a case of primary renal MFH of giant cell type in a 56-year-old man, who presented with bilateral dull flank pain, intermittent gross haematuria and body weight loss (6 kg in 3 months. Intravenous urography, computerized tomography (CT and magnetic resonance image (MRI showed right ureteral stones with mild hydronephrosis, and a solid mass at the lower pole of the left kidney associated with staghorn calculi, as well as tumour thrombi in the left renal vein and inferior vena cava. Left radical nephrectomy and evacuation of tumour thrombi from the left renal vein and inferior vena cava were performed. Histopathologic examination revealed malignant fibrous histiocytoma (MFH of giant cell type. To the best of our knowledge, this is the first report of primary renal MFH associated with staghorn calculi.

Chen C

2003-01-01

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Primary giant cell malignant fibrous histiocytoma-associated with renal calculus.  

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Malignant fibrous histiocytomas (MFH) are the most commonly seen soft tissue sarcomas in adults. It is rarely seen in some visceral organs. Kidneys are the parenchymal organs in which MFHs are most frequently seen. More than 50 cases of primary renal MFH have been reported. Among these cases, only 1 was reported as primary giant cell subtype in association with urolithiasis. This case report is the second such case with the these characteristics. PMID:24678364

Altunkol, Adem; Savas, Murat; Ciftci, Halil; Gulum, Mehmet; Yagmur, Ismail; Bitiren, Muharrem

2014-01-01

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Primary Giant Cell Malignant Fibrous Histiocytoma of the Kidney with Staghorn Calculi  

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Malignant fibrous histiocytomas (MFH) as primary renal tumours are rare, with less than 50 cases described in the literature. We report a case of primary renal MFH of giant cell type in a 56-year-old man, who presented with bilateral dull flank pain, intermittent gross haematuria and body weight loss (6 kg in 3 months). Intravenous urography, computerized tomography (CT) and magnetic resonance image (MRI) showed right ureteral stones with mild hydronephrosis, and a solid mass at the lower pol...

Chen C.; Lee P; Han W; Shen K

2003-01-01

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Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features  

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Abstract Background The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a series of 57 so-called MFH of bone within the framework of the EuroBoNeT consortium according to up-to-date criteria and ancillary immunohistochemistry, a fourth of all tumors were reclassified and subtyped. Methods In the present study, the...

Mertens Fredrik; Romeo Salvatore; Vmg, Bove?e Judith; Tirabosco Roberto; Athanasou Nick; Alberghini Marco; Cw, Hogendoorn Pancras; Dei Tos Angelo P; Sciot Raf; Domanski Henryk A; Åström Kristina; Mandahl Nils; Debiec-Rychter Maria

2011-01-01

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CERVICAL ANGIOMATOID FIBROUS HISTIOCYTOMA  

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Full Text Available Background: Angiomatoid fibrous histiocytoma (AFH is a rare type of sarcoma with low-grade malignancy that usually occurs in young subjects. AFH is uncommon in the head and neck region.Methods: We describe an exceptional case of localization in the neck. This is the first report of a rare variant of AFHpresenting in a 42-year-old woman. The tumor was situated posterior to the carotid artery adhering to the prevertebral plane and invading the sympathetic cervical chain. In this setting, we decided to perform a surgical exploration with frozen section biopsy. The frozen section revealed a fusiform tumor proliferation resembling a sarcoma. A FISH study concluded on the presence of a EWSR1 22q (22 gene rearrangement. Furthermore, the immunohistochemical studyrevealed anti-EMA positive cells. The final pathological description concluded on the presence of an AFH, which wasexcised by surgery alone.Results: After a 2 year follow-up period, the patient is free of disease. Angiomatoid fibrous histiocytoma (AFH is arare sarcoma subtype, and mis diagnosis can lead to its over treatment. A precise description of the pathologicalresponse and a multidisciplinary discussion can lead to a correct decision.Conclusion: AFH is a tumor with local evolution, and surgery is the mainstay of its management. Complete localexcision is recommended to hamper local recurrences.

Mohammad Al Felasi

2012-11-01

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MRI of malignant fibrous histiocytoma of soft tissue: analysis of 13 cases with pathologic correlation  

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We reviewed the magnetic resonance (MR) appearances of 13 malignant fibrous histiocytomas (MFH) of soft tissue and correlated each with the respective lesion's histopathology. The MR images were evaluated for signal intensity on T1- and T2-weighted spin echo sequences, homogeneity of the lesion, presence of internal low signal septations, and margin definition. Histologic subtypes of MFH included storiform-pleomorphic, giant cell, myxoid, and inflammatory. We could not establish a correlation between MR appearance and histopathology. Instead, our series exhibited general features suggestive of malignant soft tissue neoplasms, namely poor margin definition, internal low signal septation, and heterogeneous high signal intensity on T2-weighted images. (orig.)

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Primary malignant fibrous histiocytoma of the spleen: recurrence eight years after splenectomy--report of a case and literature review.  

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Primary intraabdominal malignant mesenchymal tumors are very rare. There are just few cases of intraabdominal visceral malignant fibrous histiocytoma in the literature. We report a case of primary malignant fibrous histiocytoma of the spleen in a 57-year-old man, with a recurrence eight years after the splenectomy. After the initial surgery the patient was without complaints, and refused to receive chemotherapy or radiotherapy. Eight years after the surgery the patient reported due to general weakness and malaise when the diagnosis of disease relapse was established. Radical surgery was performed although the tumor involved large curvature of the stomach, left crus of the diaphragm, splenic flexure of the colon and tail of pancreas. Four months after the surgery patient died. To the best of our knowledge, to date, only 18 cases have been reported in the literature, describing malignant fibrous histiocytoma of the spleen. PMID:24308251

Raki?, Mislav; Pogoreli?, Zenon; Lambasa, Smiljka; Patrlj, Leonardo; Perko, Zdravko; Raki?, Mladen; Mrkli?, Ivana; Juki?, Miro

2013-09-01

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Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature  

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Full Text Available Abstract Background A malignant fibrous histiocytoma is a soft tissue tumor that most commonly occurs in the extremities, but rarely involves the liver. The clinical characteristics and therapeutic experiences of primary hepatic malignant fibrous histiocytoma are still limited. Methods Two cases of primary hepatic malignant fibrous histiocytoma were analyzed retrospectively, and all the literature concerning primary hepatic malignant fibrous histiocytoma was analyzed. Results In China, a total of 76 cases had been reported, among which 50 were men, with a male to female ratio of 1.9:1. Mean age of the patients was 51.0 years old, and more than 85 percent were older than 40 years. 82.9 percent (63/76 of hepatic MFH were solitary lesions, with tumor size ranging from 2.5 to 23.5 cm (average 10.3 cm. Major clinical presentation (78.4% was abdominal pain or discomfort, accompanied with some other non-specific symptoms such as malaise, anorexia, weight loss, jaundice and fever, and small cases (14.9% were asymptomatic. Computed tomography and ultrasound usually revealed the location of lesions. The rate of pre-operative misdiagnosis was extremely high, and 14.9 percent of patients were even misdiagnosed as a benign liver cyst, liver abscess or hematoma. Integrated resection was performed among the most cases (49/68, among which only a few ones (12 cases were introduced to have no recurrence or metastasis or be still alive with no detail information provided, while among the cases with palliative operation or only a biopsy, the cases that were followed-up all died. Conclusions Hepatic malignant fibrous histiocytoma is a rare malignant mesenchymal tumor. The variable features of clinical presentations and images make the diagnosis difficult. Though the prognosis of primary hepatic malignant fibrous histiocytoma was rather poor, integrated resection might provide a few cases a good opportunity for surviving, suggesting that surgery might be an effective treatment.

Yao Dianbo

2012-01-01

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[Malignant fibrous histiocytoma of the neck with metastases to the brain].  

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A case of malignant fibrous histiocytoma with multiple brain metastases in a 48-year-old man is described. The tumour (5 X 6 cm in size) located under m. sternocleidomastoideus, surrounded inner carotid artery and grew into its wall. Pseudoaneurysm (4 X 5 cm in size) with thrombosis was found 2 cm over the tumour. There were multiple metastases (from 1 to 3 cm in diameter) in the right brain hemisphere. The tumour consisted of fibroblast-like cells, polymorphic histiocyte-like cells, with one or several nuclei, Touton cells, and osteoclast-like cells and groups of xanthoma cells. PMID:2558638

Grigor'ev, B A; Orlov, K K

1989-01-01

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Global protein-expression profiling for reclassification of malignant fibrous histiocytoma.  

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According to the newest World Health Organization (WHO) classification for soft tissue tumors in 2013, malignant fibrous histiocytoma (MFH) has been gone. Most sarcomas called MFH were reclassified to be high-grade pleomorphic forms of leiomyosarcoma, liposarcoma, rhabdomyosarcoma, and other sarcomas by recent molecular technologies. However, about 10% to 15% of sarcomas called MFH before, still cannot be given a precise classification, and these are now called undifferentiated pleomorphic sarcoma or are still called MFH. Further molecular approaches including proteomic approaches are imperative to classify these unclassified sarcomas for improving clinical outcomes of the patients with soft tissue sarcomas. This article is part of a Special Issue entitled: Medical Proteomics. PMID:25173742

Kikuta, Kazutaka; Morioka, Hideo; Kawai, Akira; Kondo, Tadashi

2014-08-28

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Malignant fibrous histiocytoma. Expression of monocyte/macrophage differentiation antigens detected with monoclonal antibodies.  

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Monoclonal antibodies were used in an investigation of the histogenesis of malignant fibrous histiocytoma (MFH), a neoplasm with morphologic features of both fibroblastic and histiocytic differentiation. In 4 cases of MFH studied, the tumor cells were found to react uniformly with antibodies to determinants expressed on monocyte macrophages (T-200, Ia, MoS-1, MoS-39, MoR-17). Both spindle and histiocyte-like tumor cells expressed these markers. In contrast, in 8 non-MFH soft tissue tumors, tu...

Strauchen, J. A.; Dimitriu-bona, A.

1986-01-01

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Post-radiation malignant fibrous histiocytoma following treatment of breast cancer: A case report  

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Post-radiation malignant fibrous histiocytoma (MFH) of the breast is extremely rare. We report a case of post-radiation MFH that presented a rapidly growing mass in a 52-year-old woman who underwent breast-conserving therapy and adjuvant whole breast irradiation 6 years ago. To the best of our knowledge, only one case of primary MFH of the female breast have been reported with sonographic findings. We analyzed the sonographic and MRI findings with correlative histopathologic features, and then confirmed with surgical excision.

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A clinicopathologic comparison of malignant fibrous histiocytoma and liposarcoma.  

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The diagnosis of MFH depends on the demonstration of histiocytic and fibroblastic functions. MFHs may phagocytose fat; therefore, lipid stains are useless. By electron microscopy, cytoplasmic lipid is membrane-bound. Immunohistochemical staining for vimentin and histiocytic markers may be helpful. Liposarcoma is diagnosed only when there is convincing evidence of synthesis and storage of fat by the tumor cells. By electron microscopy, cytoplasmic lipid is nonmembrane-bound. Both MFH and liposarcoma have subtypes. In MFH, the pleomorphic forms are the most common. Myxoid MFH is less common; all other types are rare. In liposarcoma, the myxoid types are by far the most common. The myxoid types of both MFH and liposarcoma may contain other elements that vary in degree and geographic distribution and that can raise the histologic grade. About 50% of liposarcomas are low-grade tumors; these are almost always purely myxoid. Low-grade myxoid liposarcoma has a much better prognosis than other types. Myxoid liposarcoma has a better prognosis than myxoid MFH. The peak incidence of MFH is in the seventh decade of life whereas that of liposarcoma is in the fifth decade. A substantial number (roughly 25% to 30%) of MFHs occur in the subcutaneous tissue. Clinically they are almost invariably mistaken for ganglion cysts. Liposarcoma, however, is likely to occur in or below the buttocks. Most are in the anterior thigh. Subcutaneous liposarcoma is extremely rare. A tumor in this area is likely to be either a more malignant myxoid MFH or one of the benign atypical lipomatous tumors. In both MFH and liposarcoma, the development of distant lesions is related to the tumor's histologic grade and size and to local recurrence. Favored metastatic sites of MFH are lung and lymph nodes. Favored sites of distant lesions in the myxoid/round cell types of liposarcoma are intra-abdominal, retroperitoneal, other soft-tissue areas (especially in the neck), and bone. Lymph node involvement is very rare. Because myxoid/round cell liposarcomas have a marked propensity to involve intra-abdominal sites, abdominal computed tomography and bone scan are recommended in the initial evaluation and follow-up of high-risk patients (those with high-grade tumors larger than 15 cm and those with local recurrence of intermediate- or high-grade tumors of any size). PMID:2539413

Spanier, S S; Floyd, J

1989-01-01

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Malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma of the penis. A case report  

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We report the case of a malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (MFH/UPS) of the penis in a 78-years-old-man who had undergone previous radical prostatectomy, external beam radiation therapy for prostatic adenocarcinoma. The mass was a 9-cm firm lesion at the base of the penis predominantly composed of malignant spindle cells arranged in sweeping fascicles and storiform pattern. The tumor cells stained for vimentin, ?-smooth muscle actin, S-100, and were negative for keratin, desmin, Melan A, prostate specific antigen (PSA). Despite total penectomy, he developed a local reccurence 4 months after surgery, and died from dissemination 6 months after surgery. This is the 8th case of penile MFH/UPS. (author)

 
 
 
 
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A case of radiation-induced pelvic malignant fibrous histiocytoma 8 years after radiotherapy for uterus cervical cancer  

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A case of postradiation malignant fibrous histiocytoma of the pelvis was reported. The patient is a 79-year-old woman. She was treated by radiation for cervical cancer of the uterus 8 years ago. The problem of second cancer will be more important in cancer treatment. (author)

42

Malignant fibrous histiocytoma: outcome and prognostic factors following conservation surgery and radiotherapy  

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Purpose: Malignant fibrous histiocytoma is the most common type of soft tissue sarcoma. This communication presents an analysis of outcome and prognostic factors based on a retrospective review of patients with this disease treated by conservation surgery and radiotherapy. Methods and Materials: From 1966 to 1991, 271 consecutive patients with malignant fibrous histiocytoma were treated with conservation surgery and radiotherapy. The outcome with local control, metastatic relapse, and survival as end points was evaluated by univariate and multivariate statistics to delineate independently significant prognostic factors. Results: Postoperative radiation at a mean dose of 62.8 Gy was used in 195 patients and preoperative radiation at a mean dose of 50 Gy was used in 76 patients. At a median follow-up of 7.3 years, 123 patients (45%) developed disease relapse at some site. Fifty-seven (21%) developed local recurrence leading to an actuarial local relapse rate of 26% at 10 years, 83 (31%) developed metastatic relapse for a 10-year actuarial metastatic rate of 33%, and the 5-, 10-, and 15-year survival rates were 68, 60, and 46%, respectively. For local control, prior local recurrence (in 53 patients) was identified as an adverse factor, yielding a 10-year recurrence rate of 42% compared to 22% for 218 patients without prior disease (p 5 cm), and histology (myxoid vs. nonmyxoid) were not significant determinants of local outcome. For metastatic relapse, the major determinants of outcome were histology (myxoid vs. nonmyxoid) and tumor size. Myxoid tumors (59 patients) had a low metastatic propensity (13% 10-year metastatic rate) compared to nonmyxoid tumors (212 patients) (40% 10-year metastatic rate) (p 5 cm) were the only independent determinants of outcome. Conclusion: Malignant fibrous histiocytoma is a heterogeneous disease and its myxoid variant must be recognized as a distinct entity. Both variants are locally aggressive and require equally aggressive local therapy. Conservation surgery striving for negative margins with radiation therapy provides acceptable local control and is the treatment of choice for this disease. Patients with myxoid tumors do not require systemic therapy; patients with nonmyxoid disease exceeding 5 cm are at significant risk for metastases and the development of effective adjuvant treatment is an important research goal

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Primary malignant fibrous histiocytoma in mediastinum: Imaging with {sup 18}F FDG PET/CT  

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Malignant fibrous histiocytoma (MFH) is the most common soft tumor which often occurs in the extremities and the retroperitoneum. Pimary mediastinal MFH is rare; thus, findings on {sup 18}F fluorodeoxyglucose positron emission tomography/computed tomography ({sup 18}F FDG PET/CT) of mediastinal MFH have not been reported yet. We report herein the case of a 64 year old man who was presented with a superior mediastinal mass. the mass showed intense {sup 18}F FDG uptake with central metabolic defect on PET/CT the maximum standardized uptake value was 17.4. after tumor removal via median sternotomy, an MFH of the storiform pleomorphic type was diagnosed on histopathologic examination. We the first report of {sup 18}F FDG PET/CT imaging of MFH in the superior mediastinum.

Choi, Bong Hoi [Gyeongsang National Univ. Hospital, Jinju (Korea, Republic of); Yoon, Seok Ho; Lee, Sung Soo; Jo, Kyung Sook; Song, Hee Sung; An, Young Sil; Yoon, Joon Kee; Lee, Su Jin [Ajou Univ. School of Medicine, Suwon (Korea, Republic of)

2012-12-15

44

Primary pulmonary malignant fibrous histiocytoma mimics pulmonary artery aneurysm with partial thrombosis: various radiologic evaluations  

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Primary pulmonary malignant fibrous histiocytoma (MFH) is very rare, so only a few imaging features have been reported. We report one case of rapidly growing primary pulmonary MFH mimicking a partially thrombosed pulmonary artery aneurysm and its radiologic findings, including multidetector row computed tomography (MDCT), conventional angiography, and fluorodeoxyglucose-positron emission tomography CT ([18F] FDG-PET/CT). On multi-phasic MDCT, this mass mimicked a pulmonary artery aneurysm with partial thrombosis. However, pulmonary artery aneurysm was excluded and suggested as a hypervascular parenchymal mass by subsequent conventional angiography. On [18F] FDG-PET/CT, it was a highly metabolic mass, showing a maximal standard uptake value (SUV) 12.1. Although primary pulmonary MFH is very rare and has no specific imaging findings, our experience might be helpful to differentiate a hypervascular pulmonary mass. (orig.)

45

Malignant fibrous histiocytoma of bone: conventional X-ray and MR imaging features  

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Objective. To evaluate the conventional X-ray and MR imaging features of malignant fibrous histiocytoma (MFH) of bone. Design. MRI examinations and conventional radiographs were reviewed in 39 patients with biopsy-proven MFH. Imaging characteristics were analyzed and the differential diagnoses assessed in a masked fashion by two experienced radiologists. Results. Typical X-ray features included aggressive, destructive tumor growth centrally located in the metaphysis of long bones. Periosteal reactions and expansive growth were rarely seen. On MR images extraosseous tumor spread was frequently noted. On T2-weighted images and contrast-enhanced T1-weighted images most of the tumors displayed an inhomogeneous, nodular signal pattern with peripheral Gd-DTPA enhancement. Conclusions. Although several MR imaging criteria were typical for MFH none of them was specific. X-ray diagnosis of MFH may also prove difficult, with the main differential diagnosis being metastasis in the older and osteosarcoma in the younger population. (orig.)

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Malignant fibrous histiocytoma of the scalp: A rare differential with a dramatic clinical presentation.  

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Malignant fibrous histiocytoma (MFH) a pleomorphic sarcoma of uncertain origin was first described by O'Brien and Stout in 1964. It is the most common primary soft tissue sarcoma of late adult life; its occurrence is rare in the pediatric population. MFHs are commonly known to arise in the extremities and the trunk although it can occur almost anywhere in the body. MFH of the scalp is extremely rare; moreover, there is paucity of literature with regards to prevalence of scalp and skull neoplasms. We present an unusual case of a primary MFH involving the scalp of a 5-year-old child and discuss its unusual clinical presentation, histology with immunohistochemistry correlation and its management. Reviewing the literature of primary MFH of the scalp, our patient to the best of our knowledge, is probably the youngest case reported so far. PMID:25336806

Krishnamurthy, Arvind

2014-10-01

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Characterization of human soft tissue sarcomas in nude mice. Evidence for histogenic properties of malignant fibrous histiocytomas.  

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Twenty-two human sarcomas were grafted subcutaneously into nude mice. Twelve tumors grew successfully. Nine of these 12 tumors had an aneuploid DNA content, whereas only 1 of 10 nonsuccessful tumors was aneuploid. The 12 sarcomas included two leiomyosarcomas, two malignant schwannomas, one synovial sarcoma, and seven malignant fibrous histiocytomas (MFHs). With light and electron microscopic and immunolabeling studies the original and xenografted tumors (the latter for at least two generation...

Roholl, P. J.; Rutgers, D. H.; Rademakers, L. H.; Weger, R. A.; Elbers, J. R.; Unnik, J. A.

1988-01-01

48

A case of primary malignant fibrous histiocytoma of the pancreas: CT and MRI findings  

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Full Text Available Primary malignant fibrous histiocytoma (MFH of the pancreas is rare and a distinct clinical entity. We report a case of recurrence of pancreatic MFH with computed tomography (CT and magnetic resonance imaging (MRI findings. A 67-year-old man presented with a history of decreased body weight over the past 6 mo. Abdominal CT revealed a large, multilocular cystic mass in the head of the pancreas with obvious atrophy in the body and tail of the pancreas. After 6 mo postoperatively, MRI demonstrated a recurrent large mass in the primary area of the head of the pancreas. The lesion was heterogeneous, hypointense to the liver on T1-weighted imaging, and heterogeneously hyperintense to the liver with a hypointense area in the central part of the tumor on fat-saturated T2-weighted imaging. Contrast-enhanced T1-weighted imaging demonstrated a large multilocular cystic mass with a cystic wall, fibrous septa and enhancement of solid components. To the best of our knowledge, this is the first report on recurrence of primary MFH of the pancreas, and the first with MRI findings.

Ri-Sheng Yu, Jia-Wei Wang, Ying Chen, Wen-Hong Ding, Xiu-Fang Xu, Li-Rong Chen

2008-05-01

49

Malignant fibrous histiocytoma of the urinary bladder as a post-radiation secondary cancer: a case report  

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Full Text Available Abstract Introduction Malignant fibrous histiocytomas have been periodically reported as the primary tumor in various organs including the urinary bladder, and is the second most frequent sarcoma of the urinary tract in adults. This report discusses a case of the well established diagnosis of a malignant fibrous histiocytoma of the bladder occurring as a post-radiation cancer after the treatment of a cervical carcinoma. Our findings support those of many previous studies and make the view of the nature of the disease clearer. Case presentation We report the case of a 54-year-old Thai woman who had been treated with radiation therapy for cervical cancer, who presented to our facility with urinary incontinence. Initially, our patient was diagnosed as having a high-grade urothelial carcinoma. Subsequent radical surgery rendered the final pathological diagnosis, confirmed histologically and immunohistochemically as malignant fibrous histiocytoma, with clinical and pathological staging of T4b N0 M0. Adjuvant chemotherapy was provided for our patient. Conclusions This type of malignancy is very aggressive and easily misdiagnosed due to its rarity. Therefore, in a patient with a prior history of irradiation in the pelvic area, this should be considered as a differential diagnosis to ensure early correct diagnosis and treatment.

Nimmanon Thirayost

2011-11-01

50

A radiation-induced malignant fibrous histiocytoma of the soft tissue after a carcinoma of the cervix  

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Presented are two cases of a radiation-induced malignant fibrous histiocytoma of the soft tissue following a carcinoma of the cervix. Case 1 is that of a 51-year-old female, who received postoperative radiotherapy of the pelvis, consisting of 60 Gy/25 fractions for 5 weeks. A large gluteal mass occurred 15 years later. Although this tumor responded to the radiotherapy and hyperthermia, the patient died of a recurrence 27 months later. Case 2 is that of a 62-year-old female, who underwent postoperative radiotherapy of 40 Gy/16 fractions for 4 weeks. A left gluteal tumor appeared 18 years later. After a resection of this tumor, she had repeated local recurrences. Three years after the operation, radio-hyperthermia was administered, and the patient has been doing well for a year. The histological diagnosis for both cases was a malignant fibrous histiocytoma of the ordinal type, which was considered to be a radiation-induced sarcoma. (author)

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Radiation-induced malignant fibrous histiocytoma: a report of five cases including two occurring post whole brain irradiation  

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Five patients who were successfully treated with external radiation therapy for a variety of histologically unrelated tumors subsequently developed malignant fibrous histiocytoma (MFH) within the irradiated field. It is suggested that therapeutic irradiation was a causative factor in the development of these tumors with latent periods ranging between 3 and 17 years. A review of the pertinent literature is presented. It is apparent that postradiation MFH is being recognized with increasing frequency and at an earlier age than when it appears de novo

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Simultaneous occurrence of malignant fibrous histiocytoma and hepatocellular carcinoma in cirrhotic liver: A case report.  

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Primary hepatic malignant fibrous histiocytoma (MFH) is rarely encountered. There have been no reports to date of hepatic MFH associated with liver cirrhosis. The presence of liver cirrhosis is considered an adjunctive feature favoring sarcomatoid hepatocellular carcinoma (HCC) in the diagnosis of spindle cell tumors in liver. We describe here a 59-year-old man with liver cirrhosis due to hepatitis B virus infection 20 years ago. On abdominal computed tomography scanning, two distinct hepatic masses were identified in the background of cirrhosis, which had different radiological features from conventional HCC. He underwent segmentectomy for removal of the tumors. The pathological examination of surgically resected specimen revealed the large malignant spindle cell tumor and small conventional HCC. Additional tissue sampling and immunohistochemical stainings demonstrated that the spindle cell tumor was consistent with MFH. On the post-operative follow-up for 21 mo, a round mass showing similar radiological findings for the previous MFH was appeared on the surface of resection margin, suggesting the recurrence. Despite its rarity, hepatic MFH should be considered during differential diagnosis, even in cirrhotic patients, and extensive tissue sampling and immunohistochemical analyses are necessary in the diagnosis of hepatic spindle cell tumors. PMID:21969879

Hwang, Hee Sang; Ha, Nam Du; Jeong, Yoong Ki; Suh, Jae Hee; Choi, Hye Jeong; Kim, Young Min; Cha, Hee Jeong

2011-09-27

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Histiocitoma fibroso maligno retroperitoneal: A propósito de un caso / Retroperitoneal malignant fibrous histiocytoma: case report  

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Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Presentar un caso de una tumoración retroperitoneal de gran tamaño con diagnóstico patológico de Histiocitoma fibroso maligno y revisar aspectos diagnósticos y terapéuticos de la literatura actual. Método: Presentamos el caso de un hombre de 75 años de edad que durante un ingreso en el ser [...] vicio de digestivo por clínica de astenia de meses de evolución y problemas gastrointestinales se realiza CT abdomino-pélvico, identificando gran masa de 20 x 22 x 12 cm que parece depender del riñón izquierdo junto a aneurisma de aorta abdominal de 8 cm de diámetro. Resultados: Se somete al paciente a intervención quirúrgica donde se realiza Nefrectomía radical izquierda más resección radical de masa retroperitoneal, que histológicamente corresponde a un Histiocitoma fibroso maligno, tipo estoriforme-pleomórfico con focos de degeneración hialina (Estadio pT2b). Conclusiones: Los sarcomas son neoplasias infrecuentes. Pueden adoptar una gran variedad de patrones morfológicos y distintos grados de diferenciación. El tratamiento quirúrgico continúa siendo la única terapia con posibilidades curativas. El tratamiento adyuvante radioterápico y/o quimioterápico es cuestionado. Abstract in english Objective: We present the case of a big retroperitoneal tumor that received the pathologic diagnosis of malignant fibrous histiocytoma. We also review the diagnostic and therapeutic features of this disease in the current literature. Methods: We present the case of a 75-year-old male who was admitte [...] d to the Gastrointestinal Disease Department with asthenia of several months of evolution and gastrointestinal problems. Abdominopelvic CT scan revealed a big mass of 20 x 22 x 12 cm, which seems to depend from the left kidney, together with an 8 cm diameter abdominal aortic aneurysm. Results: The patient underwent surgery and left radical nephrectomy together with radical resection of the retroperitoneal mass were performed. Pathology reportes malignant fibrous histiocytoma of the storiform-pleomorphic type, with hyaline degeneration foci (stadium pT2B). Conclusions: Sarcomas are rare neoplasias. They can adopt several different morphologic patterns, as well as many differentiation degrees. The surgical treatment is still the only therapy with healing possibilities. Adjuvant treatments through radiotherapy and/or chemotherapy are brought into question.

Pablo, Eguíluz Lumbreras; Alberto, Palacios Hernández; Oscar, Heredero Zorzo; Javier, García García; Florencio, Cañada de Arriba; Federico, Pérez Herrero; Ramón, Gómez Zancajo.

2010-08-01

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Chemically induced transplantable malignant fibrous histiocytoma of the rat. Analyses with immunohistochemistry, immunoelectron microscopy and [3H]thymidine autoradiography  

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Malignant fibrous histiocytoma was produced in rats by injection of 9,10-dimethyl-1,2-benzanthracene into their knee joints. The original tumors consisted mainly of fibroblast-like cells and histiocyte-like cells, often intermixed with bizarre giant cells, and they frequently showed the storiform-pleomorphic pattern. By immunohistochemistry, anti-rat macrophage monoclonal antibodies, TRPM-3, RM-1, and Ki-M2R, and anti-rat leukocyte common antigen reacted to the histiocyte-like cells but not to the fibroblast-like cells. By the single cell cloning method, we established six tumor cell lines, none of which reacted with the anti-rat macrophage monoclonal antibodies, possessed any Fc receptors, or conducted immune phagocytosis and Latex particle phagocytosis. The ultrastructure of the cloned tumor cells resembled that of long-term cultured dermal fibroblasts. Collagen production by the tumor cells was demonstrated immunohistochemically with a monoclonal antibody for type I collagen. Inoculation of the cloned tumor cells into rats produced tumors with the histology of malignant fibrous histiocytoma and induced prominent macrophage infiltration. In the rat tumors produced by the inoculation of [3H]thymidine labeled cells, no reactivity of tumor cells with the anti-rat macrophage monoclonal antibodies was observed. Transplantation of the cultured rat tumor cells into nude mice produced tumors similar in histology to the original rat malignant fibrous histiocytoma. Tumor cellmalignant fibrous histiocytoma. Tumor cells in nude mice induced marked macrophage infiltration as detected by immunohistochemistry with the anti-mouse macrophage monoclonal antibody F4/80. No differentiation of tumor cells into macrophages was detected, since no cells were stained with biotinylated anti-rat macrophage monoclonal antibody TRPM-3

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Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report  

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A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

Park, Hye Young; Seo, Jung Wook; Lee, Byung Hoon; Lee, Ji Young; Kim, Su Young; Cha, Soon Joo; Kim, Yong Hoon; Hwang, Yoon Joon; Kim, You Sung [Dept. of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang (Korea, Republic of)

2013-03-15

56

Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report  

International Nuclear Information System (INIS)

A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

57

Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features  

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Full Text Available Abstract Background The diagnostic entity malignant fibrous histiocytoma (MFH of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a series of 57 so-called MFH of bone within the framework of the EuroBoNeT consortium according to up-to-date criteria and ancillary immunohistochemistry, a fourth of all tumors were reclassified and subtyped. Methods In the present study, the cytogenetic data on 11 of these tumors (three myoepithelioma-like sarcomas, two leiomyosarcomas, one undifferentiated pleomorphic sarcoma with incomplete myogenic differentiation, two undifferentiated pleomorphic sarcomas, one osteosarcoma, one spindle cell sarcoma, and one unclassifiable biphasic sarcoma are presented. Results All tumors were high-grade lesions and showed very complex karyotypes. Neither the overall pattern (ploidy level, degree of complexity nor specific cytogenetic features distinguished any of the subtypes. The subgroup of myoepithelioma-like sarcomas was further investigated with regard to the status of the EWSR1 and FUS loci; however, no rearrangement was found. Nor was any particular aberration that could differentiate any of the subtypes from osteosarcomas detected. Conclusions chromosome banding analysis is unlikely to reveal potential genotype-phenotype correlations between morphologic subtypes among so-called MFH of bone.

Mertens Fredrik

2011-10-01

58

[Malignant fibrous histiocytoma. Two case reports and review of the literature].  

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The authors report two cases of malignant fibrous histiocytoma localised in the gluteus maximus and re-evaluate some clinical and biological aspects of the neoplasia. Although its histiogenesis is still unsure, the tumour can be classified into various isotopes: the vorticoid-polymorphous variety (70%), and the myxoid, giant cell, angiomatous and inflammatory varieties. It is the most common soft tissue sarcoma in adults and onset is most frequently observed on the trunk and limbs. Biological behaviour shows a marked tendency to local recidivation, with metastatic diffusion occurring mainly late. The choice of therapy consists of more or less radical surgical removal with or without ratio- and immunotherapy. The results of surgery are influenced by the technique used, and the biological and clinical behaviour of the tumour; in view of the numerous case reports of anomalous behaviour, these factors are only indicative. Therapeutic efficacy is on the whole greater in cases of tumours with diameters of less than 5 cm and more superficial localisations compared to the deep muscular fascia. PMID:9102598

Martinazzoli, A; Galati, G; Baccarini, A; Boccuzzi, M; Lutzu, S E; Spallone, M; Atella, F; Altilia, F; Corradi, R; Ceccobelli, M

1997-01-01

59

Thermoradiotherapy in the treatment of soft-tissue malignant fibrous histiocytoma of the extremities  

International Nuclear Information System (INIS)

From 1982 through 1989, five patients with soft-tissue malignant fibrous histiocytoma (MFH) of the extremities were treated with thermoradiotherapy in Kyoto University Hospital. All patients were male, and their ages ranged from 66 to 84 years. All of the tumors were locally recurrent ones following initial treatments. The initial treatments included wide excision followed by chemotherapy in one tumor, local excision with postoperative radiotherapy (60 Gy/2 Gy) in one tumor, and one to three times of local excision in the remaining three tumors. Hyperthermia was administered by an 8 MHz RF capacitive heating device or a 430 MHz microwave hyperthermia system for a total of 3 to 12 sessions (mean: 7 sessions). The total radiation dose ranged from 25 Gy to 70 Gy. regarding the tumor response, two tumors showed complete regression (CR), two showed no response (NR; less than 50% regression), and one tumor was resected 4 months after the treatment, in which no malignant tumor cells were detected by histological examination. Thus, good tumor response was obtained in three tumors. In addition, none of these tumors have shown recurrence in the follow up period of 4 to 36 months (mean: 15 months). CT scans performed after thermoradiotherapy demonstrated remarkable intratumor low density area in effectively heated tumors, and this CT change was useful to evaluate the initial effects of thermoradiotherapy. No serious complications associated with the combined treatment were notedted with the combined treatment were noted in this study. These results suggest that hyperthermia is a useful adjuvant to radiotherapy in the treatment of soft-tissue MFH of the extremities. (author)

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Post-operative radiotherapy improves survival in patients with soft tissue malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Objective: To investigate the outcomes of post-operative radiotherapy and chemotherapy and the prognostic factors in patients with soft tissue malignant fibrous histiocytoma (MFH). Methods: Between January 2001 and January 2006, 108 patients with soft tissue MFH treated in our institution, including 71 male and 37 female, were retrospectively analyzed. The median age was 56 (range 3-83) years. Sixty-eight patients had stages II disease and 40 had stage III. After radical surgery, 26 were treated with chemotherapy alone, 22 with radiotherapy alone, 11 with both and the remaining 49 with none. Kaplan-Meier method was used for survival analysis. Log-rank test and Cox regression model were used for univariate analysis and multivariate analysis, respectively. Results: The 1-, 3- and 5-year overall survival rates were 81.0%, 68.0% and 53.0%, with a median survival of 62 months. In univariate analysis, tumor size, stage and post-operative radiotherapy were significant prognostic factors for overall survival. Sex, age, tumor location and post-operative chemotherapy had no impact on survival. In multivariate analyse, only post-operative radiotherapy was an independent prognostic factor. The overall survival of patients treated with post-operative chemotherapy alone, post-operative radiotherapy alone and combined post-operative chemo-radiotherapy was similar. Patients without post-operative treatment had a worse survival than who received postoperative chemotherapy and/or radioed postoperative chemotherapy and/or radiotherapy. Conclusions: Tumor size, stage, post-operative radiotherapy are prognostic factors in patients with soft tissue MFH. Post-operative radiotherapy may be the best modality in improving the prognosis of MFH. (authors)

 
 
 
 
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Atypical fibrous histiocytoma of the great toe.  

Science.gov (United States)

Fibrous histiocytomas are benign but aggressive tumors of histiocytic origin. The authors describe and discuss an example of an atypical fibrous histiocytoma that involved the soft tissue of the great toe. These tumors sometimes recur after local excision. PMID:6330197

Jacobs, A M; Amarnek, D L; Oloff, L M

1984-01-01

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Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor.  

Science.gov (United States)

A presentation defining the nature, characteristics, causation, treatment and outcome of patients with lesions formerly known as malignant fibrous histiocytoma and now as pleomorphic spindle cell sarcoma is clearly a very difficult subject. Many authors do not believe that the tumor exists and instead describe them as forms of fibrosarcomas, fibromyxoid lesions, dedifferentiated chondrosarcomas or even leiomyosarcomas. The reasons for this confusion are presumably related to the fact that the malignant pleomorphic spindle cell sarcoma does not seem to be a distinct type of lesion with specific histologic and genetic characteristics. Instead, the tumor has at least four separate histologic variations and no specific gene signature and in fact does not seem to be either familial or ethnic in presentation. In view of the fact that the tumor was traditionally the most frequently encountered malignant soft-tissue neoplasm, the world of orthopedic oncology is clearly distressed by the problems that these patients have and is joined by the radiation oncologists and chemotherapists in seeking new solutions. PMID:23129168

Mankin, H J; Hornicek, F J; DeLaney, T F; Harmon, D C; Schiller, A L

2012-12-01

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Benign fibrous histiocytoma of the lumbar vertebrae  

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Benign fibrous histiocytoma is an extremely rare spinal tumor with ten reported cases in the literature. Benign fibrous histiocytoma constitutes a diagnostic challenge because it shares common clinical symptoms, radiological characteristics, and histological features with other benign lesions involving the spine. We present a case of benign fibrous histiocytoma of the lumbar spine and discuss its differential diagnosis and management. (orig.)

Demiralp, Bahtiyar; Oguz, Erbil; Sehirlioglu, Ali [Gulhane Military Medical Academy, Department of Orthopedics and Traumatology, Ankara (Turkey); Kose, Ozkan [Diyarbakir Education and Research Hospital, Department of Orthopedics and Traumatology, Diyarbakir (Turkey); Ataslar Serhat Evleri, Diclekent Bulvari, Diyarbakir (Turkey); Sanal, Tuba [Gulhane Military Medical Academy, Department of Radiology, Ankara (Turkey); Ozcan, Ayhan [Gulhane Military Medical Academy, Department of Pathology, Ankara (Turkey)

2009-02-15

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Histiocitoma fibroso maligno de vejiga: Revisión bibliográfica / Malignant fibrous histiocytoma of the bladder: A literature review  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivos: El histiocitoma fibroso maligno (HFM) es un tumor poco frecuente del tracto urinario. Pretendemos actualizar los criterios diagnósticos, las características anatomopatológicas e inmunohistoquímicas, la clasificación histológica, los factores pronóstico y las alternativas terapéuticas. Mat [...] erial y métodos: Revisión bibliográfica y estudio descriptivo de los casos de HFM de vejiga publicados en la literatura médica internacional. Resultados: Existen 29 casos publicados de HFM de vejiga y las variantes morfológicas más frecuentes son la estoriforme-fascicular (41%) y la inflamatoria (36%). Las variantes no mixoides comportan peor pronóstico. El 72% fue T3 en el momento del diagnóstico. La tasa de recurrencia local y a distancia del HFM de vejiga fue del 50 y del 25%, respectivamente, tras tratamiento exclusivamente quirúrgico. Conclusiones: El HFM de vejiga es un tumor con alta tasa de recurrencia local y a distancia, así como baja supervivencia, requiriendo un tratamiento precoz y agresivo. La cistectomía radical con linfadenectomía y radioterapia adyuvante, con eventual quimioterapia, se considera el tratamiento de elección. Abstract in english Objectives: Malignant fibrous histiocytoma (MFH) is an uncommon urinary tract tumor. This paper is intended to provide an update on its diagnostic criteria, pathological and immunohistochemical characteristics, histological classification, prognostic factors, and alternative treatments. Materials an [...] d methods: All published articles on MFH of the urinary bladder have been reviewed and a descriptive study has been done. Results: Twenty-nine cases of MFH of the bladder have been reported. The most common morphological variants are storiform-fascicular (41%) and inflammatory (36%) MFH. Non-myxoid variants have a poorer prognosis. Stage T3 MFH was found in 72% of cases at the time of diagnosis. MFH local recurrence and distant metastasis rates were 50% and 25% respectively after surgical treatment only. Conclusions: MFH of the bladder is a tumor with high local and distant recurrence rates and a low survival rate, and therefore requires early and aggressive treatment. Radical cystectomy with lymphadenectomy and adjuvant radiotherapy is considered to be the treatment of choice, eventually associated to chemotherapy.

I., Povo-Martín; D., Gallego-Vilar; M., Bosquet-Sanz; J., Miralles-Aguado; V., Gimeno-Argente; M., Rodrigo-Aliaga; J., Gallego-Gómez.

2010-04-01

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Characterization of tumor cells in malignant fibrous histiocytomas and other soft-tissue tumors, in comparison with malignant histiocytes. II. Immunoperoxidase study on cryostat sections.  

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The authors have investigated a possible relationship between tumor cells of malignant fibrous histiocytomas (MFHs) and histiocytes. This relationship was studied by means of immunophenotyping using monoclonal antibodies specific for the monocyte cell lineage (FMC-17, Mac-1, OKM-1, Leu-M1, and lysozyme) and mono- and polyclonal antibodies specific for fibroblasts (respectively, FIB-86 and FSG). The immunophenotypes of the MFH tumor cells were compared with those of tumor cells of "true" histi...

Roholl, P. J.; Kleyne, J.; Unnik, J. A.

1985-01-01

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An adult patient who developed malignant fibrous histiocytoma 9 years after radiation therapy for childhood acute lymphoblastic leukemia  

International Nuclear Information System (INIS)

A 24-year-old Japanese man with a history of acute lymphoblastic leukemia, which occurred during childhood, developed malignant fibrous histiocytoma of his left knee. His past history revealed that he had undergone leukemic blast cell invasion of the left knee and subsequent radiation therapy 9 years ago. The total radiation doses for the upper part of the left tibia and the lower part of the left femur were 60 Gy and 40 Gy, respectively. Neither distant metastasis nor a relapse of leukemia occurred. A curative resection of the left femur with a noninvasive margin was performed. Adjuvant chemotherapy including high-dose methotrexate was given successfully before and after surgery; this was followed by relapse-free survival for 3 years. The nature of postirradiation malignant fibrous histiocytoma is highly aggressive. When a patient complains of persistent symptoms in a previously irradiated field, the possibility of this tumor must be taken into account. The importance of early diagnosis cannot be over-emphasized. (author)

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A new complication of retained surgical gauze: development of malignant fibrous histiocytoma – report of a case with a literature review  

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Full Text Available Abstract Background Primary visceral malignant fibrous histiocytoma (MFH is a rare disease, and few cases have been reported in the English literature. However, retained foreign bodies in the abdomen after surgical procedures are important causes of intra-abdominal infections. For legal and ethical reasons, there are few publications in the literature. In this article, we describe for the first time a case of malign abdominal fibrous histiocytoma associated with a surgical sponge forgotten in the abdominal cavity a long time ago. Case presentation A 64-year-old male presented to our surgical department with cachexia, abdominal pain, distention and pyrexia of unknown origin. He had a medical history of abdominal surgery for peptic ulcer perforation 32?years ago. Clinical examination revealed fever with a distended and painful abdominal wall. Radiological imaging of the abdomen showed multiple heterogeneous masses in one large cystic cavityalmost completely filling the abdomen. The patient underwent a laparotomy, and interestingly, opening the cyst revealed retained surgical gauze (RSG. The origin of the tumor was the visceral peritoneum, and it was excised totally. Conclusions Primary intra-abdominal MFH can present as a complication of long-lasting RSG. Therefore, clinicians must remember this while establishing the differential diagnosis for patients with a history of previous abdominal surgery and presenting with symptoms associated with both the tumor and systemic inflammatory response.

Kaplan Mehmet

2012-07-01

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An adult patient who developed malignant fibrous histiocytoma 9 years after radiation therapy for childhood acute lymphoblastic leukemia  

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A 24-year-old Japanese man with a history of acute lymphoblastic leukemia, which occurred during childhood, developed malignant fibrous histiocytoma of his left knee. His past history revealed that he had undergone leukemic blast cell invasion of the left knee and subsequent radiation therapy 9 years ago. The total radiation doses for the upper part of the left tibia and the lower part of the left femur were 60 Gy and 40 Gy, respectively. Neither distant metastasis nor a relapse of leukemia occurred. A curative resection of the left femur with a noninvasive margin was performed. Adjuvant chemotherapy including high-dose methotrexate was given successfully before and after surgery; this was followed by relapse-free survival for 3 years. The nature of postirradiation malignant fibrous histiocytoma is highly aggressive. When a patient complains of persistent symptoms in a previously irradiated field, the possibility of this tumor must be taken into account. The importance of early diagnosis cannot be over-emphasized. (author)

Kato, Yasuhiro [National Hiroshima Hospital, Higashi-Hiroshima (Japan); Ohno, Norioki; Horikawa, Yoko; Nishimura, Shin-ichiro; Ueda, Kazuhiro; Shimose, Shoji [Hiroshima Univ. (Japan). School of Medicine

2002-12-01

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Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization  

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Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH) is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluoresce...

Isayama Teruto; Ishiguro Masako; Nabeshima Kazuki; Iwasaki Hiroshi; Nishio Jun; Naito Masatoshi

2010-01-01

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Benign Fibrous Histiocytoma of the Maxillary Sinus  

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Fibrous Histiocytoma is an uncommon neoplasm of the Head and Neck region and quite rare in the paranasal sinuses. We are reporting a case of Benign Fibrous Histiocytoma in the Maxillary sinus from the Department of Otorhinolaryngology of Bolani Hospital, Bolani with a description of clinical and histological features of the neoplasm.

Singh, Mangal

1999-01-01

71

CyberKnife radiotherapy for malignant fibrous histiocytoma of the chest wall: A case report and review of the literature.  

Science.gov (United States)

Malignant fibrous histiocytoma (MFH) is the most common type of soft tissue sarcoma, but rarely originates in the chest wall. Surgical resection is considered to be the most reliable treatment, however, no consensus has been reached concerning the best treatment for unresectable MFH. The current study presents the case of a 77-year-old male with MFH of the chest wall. The patient developed a painless mass and intermittent fever over a four-month period. A computed tomography scan demonstrated a large inhomogeneous lesion in the right chest wall, which was subsequently diagnosed via biopsy as a MFH. Since the tumor was an unresectable mass, CyberKnife(®) radiotherapy was conducted. Following the treatment, a marked reduction in the tumor size was observed with a tolerable level of toxicity. The sequencing analysis also revealed an in-frame deletion (delE746-A750) in exon 19 of the epidermal growth factor receptor gene. Based on this result, gefitinib was administered to the patient at a dose of 250 mg/day. PMID:24932251

Wang, Zhen; Wu, Xin-Hu; Li, Bing; Kong, Qing-Tao; Shen, Ze-Tian; Li, Jing; Liu, Zhi-Bing; Zhu, Xi-Xu

2014-06-01

72

Transcutaneous application of CO2 enhances the antitumor effect of radiation therapy in human malignant fibrous histiocytoma.  

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Sarcomas are relatively resistant because of hypoxia. We previously demonstrated that the transcutaneous CO(2) therapy reduced hypoxic conditions in human malignant fibrous histiocytoma (MFH). Therefore, we hypothesized that transcutaneous CO(2) therapy could enhance the antitumor effect of radiation therapy in human MFH. Our purpose was to evaluate the effects of transcutaneous CO(2) therapy on the antitumor efficacy of X-ray irradiation using MFH. First, in an in vitro study, we assessed apoptotic activity and reactive oxygen species (ROS) production using flow cytometric and immunoblot analysis at 24 h after X-ray irradiation under three different oxygen conditions (normoxic, reoxygenated and hypoxic). In addition, in the in vivo study, 24 male athymic BALB/c nude mice with MFH tumors that were inoculated in the dorsal subcutaneous area were randomized into four groups: control, CO(2), X-ray irradiation and combination (CO(2) and X-ray irradiation). Treatments were performed twice weekly for 2 weeks, four times in total. Tumor volume was calculated. All tumors were excised and apoptotic activity, ROS production, related proteins and HIF-1? expression were assessed using flow cytometric and immunoblot analysis. The in vitro study revealed that X-ray irradiation induced increased apoptosis and ROS production in MFH cells under normoxic and reoxygenated conditions relative to hypoxic conditions (P<0.01). In the in vivo study, tumor volume in the combination group was reduced to 28, 42 and 47% of that in the control, CO(2), and X-ray groups, respectively (P<0.05). Apoptotic activity and ROS production in the combination group were strongly increased with decreasing HIF-1? expression relative to the control, CO(2) and X-ray groups. The transcutaneous CO(2) system enhanced the antitumor action of X-ray irradiation and could be a novel therapeutic tool for overcoming radio-resistance in human malignancies. PMID:24889546

Onishi, Yasuo; Akisue, Toshihiro; Kawamoto, Teruya; Ueha, Takeshi; Hara, Hitomi; Toda, Mitsunori; Harada, Risa; Minoda, Masaya; Morishita, Masayuki; Sasaki, Ryohei; Nishida, Kotaro; Kuroda, Ryosuke; Kurosaka, Masahiro

2014-08-01

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Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report.  

Science.gov (United States)

Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses. The patient had no other primary malignant neoplasm, thus excluding a metastatic lesion. Gross examination revealed a thickened right pulmonary artery and a necrotic and hemorrhagic tumor, filling and occluding the vascular lumen. The mass extended distally, within the pulmonary vasculature of the right lung. Microscopically, an intravascular undifferentiated tumor was identified. The tumor cells showed expression for vascular markers VEGFR, VEGFR3, PDGFRa, FGF, Ulex europaeus, FVIII, FLI-1, CD31 and CD34; p53 was overexpressed and Ki67 proliferative rate was increased. Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome. PMID:23134683

Bohn, Olga L; de León, Eric Acosta-Ponce; Lezama, Oscar; Rios-Luna, Nina P; Sánchez-Sosa, Sergio; Llombart-Bosch, Antonio

2012-01-01

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Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report  

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Full Text Available Abstract Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses. The patient had no other primary malignant neoplasm, thus excluding a metastatic lesion. Gross examination revealed a thickened right pulmonary artery and a necrotic and hemorrhagic tumor, filling and occluding the vascular lumen. The mass extended distally, within the pulmonary vasculature of the right lung. Microscopically, an intravascular undifferentiated tumor was identified. The tumor cells showed expression for vascular markers VEGFR, VEGFR3, PDGFRa, FGF, Ulex europaeus, FVIII, FLI-1, CD31 and CD34; p53 was overexpressed and Ki67 proliferative rate was increased. Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome. Virtual slide The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2315906377648045.

Bohn Olga L

2012-11-01

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Eight-year follow-up of malignant fibrous histiocytoma (undifferentiated high-grade pleomorphic sarcoma of the maxilla: case report and review of the literature  

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Full Text Available Malignant fibrous histiocytoma (MFH is the most common soft tissue sarcoma of late adult life and may also arise as a primary tumor in bone. It is a rare condition that constitutes less than 1% of the malignant tumors of bone and commonly occurs in the mathaphysis of long bones of extremities such as the femur and tibia. The occurrence in the head and neck region is very rare. MFH of the jaws is a highly malignant tumor that recurs, metastasizes, and usually causes death despite aggressive surgical therapy. We present a case of MFH of maxilla with 8 years follow-up. The clinical, pathologic and radiographic features as well as the treatment of this case are discussed.

Hossein Shahoon

2009-03-01

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Imaging of soft tissue malignant fibrous histiocytoma; Place de l`imagerie dans le bilan des histiocytomes fibreux malins des parties molles  

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Malignant fibrous histiocytoma (MFH) is a rare and potentially highly malignant sarcoma. The authors report 6 cases of MFH in various sites : two in the chest wall, one in the pelvis, two in the gluteal zones and one on the scalp. Ultrasonography and computed tomography were the main imaging methods used in the assessment of the structure and extension of the tumor. A poor prognosis was noted in four cases: death within a few months in the two thoracic sites, recurrence in the pelvic and scalp lesions, radical surgery allowed recovery in two cases. A review of the literature showed that MRI and CT are complementary in the initial staging and follow-up these patients. (author)

Jemni, H.; Bakir, D.; Ben Ahmed, S.; Kraiem, C. [Centre Hospitalier Universitaire F. Hached, Sousse (Tunisia); Mrad Dali, K.; Tlili-Graiess, K.; Mnif, Z.; Jeddi, M. [Centre Hospitalier Universitaire Sahloul, Sousse (Tunisia)

1996-12-31

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Calculation of probability of causation for non-specified radiogenic cancer cases. Etiologic judgement of a malignant fibrous histiocytoma developed at the elbow of a plutonium contaminated worker  

International Nuclear Information System (INIS)

A criterion for the compensation of patients with radiogenic cancer has been formulated for five specified cancers. A method of calculation of the probability of causation (PC) of non-specified cancers was applied to a case of malignant fibrous histiocytoma developed at the elbow of a plutonium contaminated worker. According to the histologic structure of the tumour, there were three possible target cells, and their doses were evaluated with the available data of urine plutonium. Then PC was calculated with excess relative risk coefficient indirectly deduced from related animal experiment. The result showed that the obtained PC varied greatly with the supposed target cells. If the target cells were periosteum cells, the PC might exceed 50 percent, but that might not be true, and the tumour might come from fibroblasts, and then PC might be less than 1 percent

78

Aneurysmal and haemangiopericytoma-like fibrous histiocytoma.  

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AIM: To describe the clinicopathological features of 33 aneurysmal fibrous histiocytomas (AFH), including five cases with a haemangiopericytoma-like pattern. METHODS: Thirty three cases of AFH were studied by using routine histology and immunohistochemistry for factor XIIIa, the "cell activity marker" E9 (anti-metallothionein), NK1C3 (CD57), smooth muscle actin (SMA), factor VIII, ulex europaeus agglutinin, JC70A (CD31), and QBEND10 (CD34). The time dependent variation in histopathological fe...

Zelger, B. W.; Zelger, B. G.; Steiner, H.; Ofner, D.

1996-01-01

79

Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluorescence in situ hybridization (M-FISH, Urovysion™ FISH, and comparative genomic hybridization (CGH for the characterization of chromosomal aberrations. FU-MFH-2 cells were spindle or polygonal in shape with oval nuclei, and were successfully maintained in vitro for over 80 passages. The histological features of heterotransplanted tumors in severe combined immunodeficiency mice were essentially the same as those of the original tumor. Cytogenetic and M-FISH analyses displayed a hypotriploid karyotype with numerous structural aberrations. Urovysion™ FISH revealed a homozygous deletion of the p16INK4A locus on chromosome band 9p21. CGH analysis showed a high-level amplification of 9q31-q34, gains of 1p12-p34.3, 2p21, 2q11.2-q21, 3p, 4p, 6q22-qter, 8p11.2, 8q11.2-q21.1, 9q21-qter, 11q13, 12q24, 15q21-qter, 16p13, 17, 20, and X, and losses of 1q43-qter, 4q32-qter, 5q14-q23, 7q32-qter, 8p21-pter, 8q23, 9p21-pter, 10p11.2-p13, and 10q11.2-q22. Conclusion The FU-MFH-2 cell line will be a particularly useful model for studying molecular pathogenesis of human pleomorphic MFH.

Isayama Teruto

2010-11-01

80

Case report 359: Gigantic benign fibrous histiocytoma (nonossifying fibroma)  

International Nuclear Information System (INIS)

In summary, a fascinating case is presented of an enormous 'blow-out' lesion in the left half of the mandible in a 17-year-old boy. The histological diagnosis was benign fibrous histiocytoma or non-ossifying fibroma. An extensive differential diagnosis was presented by the authors and although benign fibrous histiocytoma was their final diagnosis, they could not exclude an example of the rarely encountered entity called the Jaffe-Campanacci syndrome. This syndrome consists of multiple non-ossifying fibromas of the mandible, cafe-au-lait spots, various endocrine disorders, mental retardation, occular anomalies and cardiovascular malformations. (orig./SHA)

 
 
 
 
81

Primary stromal sarcoma of breast with malignant fibrous histiocytoma-like features causing diagnostic dilemma on fine-needle aspiration cytology in a patient with squamous cell carcinoma of cervix: a case report.  

Science.gov (United States)

A variety of malignant spindle-cell tumors are known to occur in the breast, which are collectively referred to as "breast spindle-cell tumors." Their interpretation on fine-needle aspiration cytology (FNAC) can be highly tricky. Here, we report a case. A 47-year-old female presented with a hard, mobile lump in the right breast for 4 months. Five years previous to this, she was treated with radiotherapy for squamous-cell carcinoma (SCC) of cervix. FNA of the breast lump showed high-cell yield with clusters, fascicles, and dissociated cells displaying spindle-cell morphology, with marked pleomorphism, many bizarre uninucleate/multinucleate giant cells, and a striking mitotic activity. At places, the cells in a necrotic background simulated keratinized squamous cells. Considering the past history of SCC of cervix, the first possibility of metastatic SCC with a differential diagnosis of metaplastic carcinoma, malignant phylloides, and a primary sarcoma of the breast was considered. Subsequent trucut/excision biopsy with appropriate immunomarkers revealed it to be a case of primary stromal sarcoma of the breast with malignant fibrous histiocytoma (MFH)-like features. Malignant spindle-cell tumor of breast in a patient with SCC of cervix (which also has a tendency to manifest with spindle cell morphology) can cause genuine diagnostic difficulty. In such patients, use of appropriate panel of markers is mandatory for distinguishing between the metastatic SCC from cervix and other more commonly occurring spindle-cell malignancies of the breast. PMID:20607805

Prasad, Priyavadhana Rajan; Kumar, Bipin; Kumar, Surendra; Basu, Debdatta; Siddaraju, Neelaiah

2011-03-01

82

Benign fibrous histiocytoma of larynx: A rare cause of acute airway obstruction  

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Fibrous histiocytoma of larynx is a rare entity. We herein present a 35-year-old femaleof benign fibrous histiocytoma of larynx with severe airway obstruction that requiring urgent endotracheal intubation followed by tracheostomy. We also report the good long-term survival of this case after such a critical condition.

Gupta Shiv; Singhal Sanjay

2010-01-01

83

Recurrent painful perianal subcutaneous angiomatoid fibrous histiocytoma: a case report and review of the literature.  

Science.gov (United States)

Angiomatoid fibrous histiocytoma (AFH) is a rare, low-grade malignant soft-tissue tumor most commonly occurring in the extremities of children and young adults and has a low potential of local recurrence and metastasis. Here, we present a case of recurrent subcutaneous perianal AFH. After an initial diagnosis as a sebaceous cyst, we were able to use immunohistochemical findings to correctly identify the mass as an AFH. The patient was effectively treated after 3 surgical resections. This case emphasizes the need to correctly diagnose soft-tissue tumors using a variety of diagnostic modalities to ensure that the patient receives proper treatment. PMID:25526437

Kong, Xiangyi; Zhao, Dachun; Lin, Guole; Zhou, Jiaolin; Cui, Quancai

2014-12-01

84

Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum.  

Science.gov (United States)

Angiomatoid fibrous histiocytoma, a fibrohistiocytic tumour of intermediate malignancy that usually presents on extremities of young patients, has a broader clinical/histological spectrum than is widely appreciated. We summarise our experience with an emphasis on unusual features. Twenty-seven cases were analysed for clinical and histological features, including immunohistochemistry and FISH for rearrangements of EWSR1 or FUS. Five (19%) occurred in patients >40 years old, and ten (37%) occurred outside the extremities. Three that occurred in patients >40 years old arose in atypical locations. Evaluation for classical histological features (lymphocytic cuff, fibrous pseudocapsule, pseudovascular spaces, haemorrhage, haemosiderin, and histiocytoid morphology) showed that all had two or more classical features. Unusual features were noted in many cases. Ten (37%) displayed significant areas of sclerosis; three of these ten had areas with a perineurioma-like pattern. Nine displayed at least moderate pleomorphism, with two exhibiting striking pleomorphism. Eight had eosinophils in the stroma, one with numerous eosinophils. One had a reticulated pattern of cells in a myxoid stroma. Mitotic rates were low [average 0.67/10 high power fields (HPFs)]. Three had atypical mitotic figures. Thirteen of 20 (65%) were CD68 positive, 11 of 17 (65%) were EMA positive, and 10 of 18 (56%) were desmin positive. Thirteen of 16 (81%) had a rearrangement of EWSR1; none had a FUS rearrangement.This series expands the spectrum of angiomatoid fibrous histiocytoma. PMID:24614712

Bohman, Summer L; Goldblum, John R; Rubin, Brian P; Tanas, Munir R; Billings, Steven D

2014-04-01

85

Fibroistiocitoma angiomatóide com metástase ao diagnóstico: relato de caso e revisão da literatura Angiomatoid fibrous histiocytoma presenting metastasis: case report and literature review  

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Full Text Available O fibroistiocitoma maligno variante angiomatóide constitui entidade rara e geradora de controvérsia, especialmente quanto a sua histogênese. Apresenta como peculiaridades o acometimento preferencial da faixa etária pediátrica e o comportamento biológico indolente, tendo baixas taxas de metastatização. No presente caso, paciente feminina de 6 anos apresentou, em decorrência de lesão em extremidade inferior, metástase linfonodal inguinal.Angiomatoid malignant fibrous histiocytoma is a rare and controversial entity, particularly as to its histogenesis. The tumor affects mostly the pediatric group, with an indolent clinical course and low rate of metastatization. In this report, the patient presented a lesion in the right foot and metastasis in an inguinal lymph node.

Thaís Heinke

2004-08-01

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Fibrohistiocitoma benigno ósseo na coluna lombar Benign fibrous histiocytoma of the lumbar spine  

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Full Text Available CONTEXTO: O fibrohistiocitoma benigno intra-ósseo é uma neoplasia rara, caracterizada por proliferação fibroblástica e fibras colágenas. A dor na região lombar é uma queixa freqüente em muitos pacientes, mas, na maioria das vezes está relacionada com causa muscular ou degenerativa. RELATO DE CASO: Relata-se aqui o caso de um paciente com diagnóstico de fibrohistiocitoma benigno ósseo na coluna lombar que apresentava queixa de lombalgia há cinco meses antes do diagnóstico. Foi submetida à biópsia aberta transpedicular na quarta vértebra lombar ,e, posteriormente realizada curetagem da lesão via anterior retroperitonial e artrodese vertebral de L3-L5 com enxerto de fíbula. CONCLUSÃO: Apesar de raro, o fibrohistiocitoma benigno intra-ósseo deve ser uma das hipóteses quando observamos uma lesão primária na coluna vertebral.CONTEXT: Benign intraosseous fibrous histiocytoma is a rare neoplasia, characterized by fibroblastic and collagenous fiber proliferation. Pain in the lumbar region is a frequent complaint in many patients, but most of times it is associated to muscular or degenerative causes. CASE REPORT: Here we report a case of a patient diagnosed with benign bone fibrous histiocytoma in the lumbar spine who complained of lumbar pain dating five months prior to diagnosis. The patient was submitted to open transpedicular biopsy in the forth lumbar vertebra, and subsequently, lesion curettage was performed via anterior retroperitoneal and L3-L5 vertebral arthrodesis using a fibular graft. CONCLUSION: Although rare, benign intraosseous fibrohistiocytoma should be taken into consideration when a primary lesion is observed in the spine.

Osmar Avanzi

2005-01-01

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Fibrohistiocitoma benigno ósseo na coluna lombar / Benign fibrous histiocytoma of the lumbar spine  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese CONTEXTO: O fibrohistiocitoma benigno intra-ósseo é uma neoplasia rara, caracterizada por proliferação fibroblástica e fibras colágenas. A dor na região lombar é uma queixa freqüente em muitos pacientes, mas, na maioria das vezes está relacionada com causa muscular ou degenerativa. RELATO DE CASO: R [...] elata-se aqui o caso de um paciente com diagnóstico de fibrohistiocitoma benigno ósseo na coluna lombar que apresentava queixa de lombalgia há cinco meses antes do diagnóstico. Foi submetida à biópsia aberta transpedicular na quarta vértebra lombar ,e, posteriormente realizada curetagem da lesão via anterior retroperitonial e artrodese vertebral de L3-L5 com enxerto de fíbula. CONCLUSÃO: Apesar de raro, o fibrohistiocitoma benigno intra-ósseo deve ser uma das hipóteses quando observamos uma lesão primária na coluna vertebral. Abstract in english CONTEXT: Benign intraosseous fibrous histiocytoma is a rare neoplasia, characterized by fibroblastic and collagenous fiber proliferation. Pain in the lumbar region is a frequent complaint in many patients, but most of times it is associated to muscular or degenerative causes. CASE REPORT: Here we re [...] port a case of a patient diagnosed with benign bone fibrous histiocytoma in the lumbar spine who complained of lumbar pain dating five months prior to diagnosis. The patient was submitted to open transpedicular biopsy in the forth lumbar vertebra, and subsequently, lesion curettage was performed via anterior retroperitoneal and L3-L5 vertebral arthrodesis using a fibular graft. CONCLUSION: Although rare, benign intraosseous fibrohistiocytoma should be taken into consideration when a primary lesion is observed in the spine.

Osmar, Avanzi; Lin Yu, Chih; Robert, Meves; José Donato, Próspero; Amarildo, Brito.

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Fibroistiocitoma angiomatóide com metástase ao diagnóstico: relato de caso e revisão da literatura / Angiomatoid fibrous histiocytoma presenting metastasis: case report and literature review  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O fibroistiocitoma maligno variante angiomatóide constitui entidade rara e geradora de controvérsia, especialmente quanto a sua histogênese. Apresenta como peculiaridades o acometimento preferencial da faixa etária pediátrica e o comportamento biológico indolente, tendo baixas taxas de metastatizaçã [...] o. No presente caso, paciente feminina de 6 anos apresentou, em decorrência de lesão em extremidade inferior, metástase linfonodal inguinal. Abstract in english Angiomatoid malignant fibrous histiocytoma is a rare and controversial entity, particularly as to its histogenesis. The tumor affects mostly the pediatric group, with an indolent clinical course and low rate of metastatization. In this report, the patient presented a lesion in the right foot and met [...] astasis in an inguinal lymph node.

Thaís, Heinke; Marcello, Franco; Maria Teresa de Seixas, Alves; Lucila Böhme, Pellacani; Ângela Navarro, Gordan; Antonio Sérgio, Petrilli.

2004-08-01

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Fibrohistiocitoma maligno "inflamatorio" de cordón espermático con infiltración sobre un leiomioma inguinal: Presentación de 1 caso con revisión conceptual y de la literatura / Inflammatory malignant fibrous histiocytoma of the spermatic cord infiltrating an inguinal leiomyoma: Case report with conceptual and bibliogrphic reviews  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Estudiar los fibrohistiocitomas malignos (FHM) paratesticulares desde el punto de vista clínico-histológico, inmunohistoquímico y su histogénesis. Métodos: A través de Medline y búsqueda no indexada de la literatura científica internacional hemos encontrado un total de 77 casos de FHM para [...] testiculares que globalmente plantean problemas diagnósticos, terminológicos y terapeúticos. Resultado: Incluímos el caso número 78 de FHM de cordón espermático que presenta unas especiales características (no descritas hasta la fecha) de fistulización cutánea e infiltración de un leiomioma inguinal, con confirmación histológica e inmunohistoquímica. Realizamos una revisión conceptual de este tipo de neoplasias incluyendo la valoración de las contradicciones y reclasificaciones que ha sufrido desde su primera descripción, lo que hace que sean subestimados y su prevalencia real en las series internacionales sea muy variable: del 7 al 37% de los sarcomas paratesticulares. También, el hecho de su baja incidencia ha condicionado una carencia de protocolos de diagnóstico y tratamiento. Conclusiones: Los tumores paratesticulares, aunque infrecuentes, tienen una alta tasa de malignidad. El concepto de FHM ha variado a lo largo de los últimos 15 años. Hoy, este término, es sinónimo de sarcoma pleomórfico indiferenciado y ha llegado a ser un diagnóstico de exclusión (Vimentina + / CD 68 + -ocasionalmente- sin diferencias ultraestructurales), reservándose el subtipo inflamatorio para aquellos que tienen un componente inflamatorio e histiocítico. Es imprescindible en esta localización la realización de una biopsia intraoperatoria, ya que incluso es difícil precisar preoperatoriamente, si una lesión es benigna o maligna. El diagnóstico diferencial tan solo se resuelve tras el estudio microscópico e inmunohistoquímico. Un leiomioma próximo a esta localización (inguinal) podría diagnosticarse y confundirse con un nódulo del FHM principal. Su inmunofenotipo nos permitió diagnosticarlo no solo como leiomioma (marcadores de actinas y desmina positivos), sino también observar la infiltración por el FHM. Abstract in english Objectives: To study paratesticular malignant fibrous histiocytomas (FHM) from the clinical, histological, immunohistochemical and histogenetic, point of view. Methods: Through Medline and not index-linked search of international scientific literature we have found a total of 77 cases of paratesticu [...] lar FHM that globally create diagnostic, terminological and therapeutic problems. Results: We include the case number 78 of FHM of spermatic cord, that presents a few special characteristics (not described before) of cutaneous fistula and infiltration of an inguinal leiomyoma, with histological and immunohistochemical confirmation. We performed a conceptual review of this type of tumours, including the evaluation of contradictions and reclassifications that has undergone from its first description, which causes that they are underestimated and their real prevalence in international series is very variable: from 7 to 37 % of paratesticular sarcomas. Also, the fact of their low incidence has determined the lack of protocols for diagnosis and treatment. Conclusions: Paratesticular tumours, although infrequent, have a high rate of malignancy. The FHM concept has varied throughout the last 15 years. Today, this term is synonymous of pleomorphic undifferentiated sarcoma and has been an exclusion diagnosis (Vimentin [+] / CD 68 [+] - occasionally - without ultrastructural differences), reserving the inflammatory subtype for which they have an inflammatory and histiocytic component. The accomplishment of an intraoperatory biopsy is essential in this location, since it is even difficult to know preoperatively, if a lesion is benign or malignant. The differential diagnosis is only solved after microscopic and inmunohistochemical study. Leiomyoma next to this location (inguinal) could be diagnosed and confus

Juan Manuel, Ruiz Liso; Juan, Ruiz García; María Luisa, Pardo López; Agustín, Vaillo Vinagre; Antonia, Gutiérrez Martín; María Cruz, Marrón Martínez; María Ascensión, García Pérez.

2008-05-01

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General Information about Osteosarcoma and Malignant Fibrous Histiocytoma of Bone  

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... surgery. The patient may be fitted with a prosthesis (artificial limb) after amputation. Rotationplasty : Surgery to remove the tumor and the knee joint . The part of the leg that remains below the knee is then ... as a knee. A prosthesis may then be attached to the foot. Studies ...

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Fibrohistiocitoma conjuntival simulando pterígio atípico na região amazônica: relato de caso / Conjunctival fibrous histiocytoma simulating atipical pterygium in the Amazon region: case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Relatamos um caso inédito na literatura brasileira de fibrohistiocitoma conjuntival descoberto durante projeto comunitário de larga escala realizado pela equipe do Centro de Referência em Oftalmologia do Hospital das Clínicas da Universidade Federal de Goiás na região amazônica. Paciente do sexo fem [...] inino, leucoderma, de 38 anos de idade, apresentava lesão vascularizada no olho direito no canto medial da conjuntiva bulbar e carúncula com extensão para o limbo e invadindo cerca de 2 mm da córnea medial com configuração semelhante a um pterígio. O exame histopatológico revelou lesão constituída por células fusiformes, com arranjo estoriforme e células histiocitárias gigantes. A imunohistoquímica revelou forte positividade para vimentina e as células neoplásicas foram negativas para AE1/ AE3, HMB 45, proteína S 100. O diagnóstico histopatológico foi de fibrohistiocitoma. A evolução poderá demonstrar o crescimento tumoral e a possibilidade de lesão maligna. Abstract in english An inedited case in the Brazilian literature of conjunctival fibrous histiocytoma discovered during a wide scale community project accomplished by the team of the Center of Reference in Ophthalmology of the Hospital das Clínicas da Universidade Federal de Goiás in the Amazon region is reported. A 38 [...] year-old caucasian woman presented with a vascularized lesion on the medial portion of the bulbar conjunctiva and caruncular region of the right eye with extension for the limbus and invading about 2 mm of the medial cornea resembling a pterygium. Pathologic findings revealed that the lesion was constituted by spindle-shaped cells, with storiform arrangement, and large histocytelike cells. The immunohistochemistry revealed strong positivity for vimentin and the neoplastic cells were negative for AE1/AE3, HMB 45, S 100 protein. The histopathologic diagnosis was fibrous histiocytoma. The evolution demonstrated the tumoral growth and the possibility of a malignant lesion.

Roberto Murillo Limongi de Souza, Carvalho; Alexandre, Taleb; Giulianna Limongi de Souza, Carvalho; Marcos, Ávila.

2010-12-01

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Malignant transformation of fibrous dysplasia into chondroblastic osteosarcoma  

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A case of malignant transformation of polyostotic fibrous dysplasia into maxillary chondroblastic osteosarcoma is presented. The clinical, radiographic, CT, MR imaging features and pathological findings of polyostotic fibrous dysplasia and its malignant transformation are described. Malignant transformation of fibrous dysplasia is rare and has not previously been described in the English literature in this location in McCune-Albright syndrome and in the absence of radiation treatment. (orig.)

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Malignant transformation in monostotic fibrous dysplasia: clinical features, imaging features, outcomes in 10 patients, and review.  

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Malignant transformation in fibrous dysplasia (FD) is uncommon. The purpose of this study was to investigate clinical and imaging features, and outcomes of malignant transformation in monostotic FD.Data for 10 pathologically confirmed malignant transformations in monostotic FD from January 2005 to December 2013 were retrospectively reviewed. Patient data were recorded, and radiographs (n?=?10), computed tomography (CT) (n?=?5), magnetic resonance (MR) (n?=?4), and bone scintigrams (n?=?10) were evaluated for lesion location, margin, cortical destruction, marrow involvement, periosteal reaction, and soft tissue mass by 2 musculoskeletal radiologists with agreement by consensus. Clinical features, management, and prognosis were also analyzed for each of the 10 cases.There were 8 male and 2 female patients (mean age 46.5?±?15.9 years). The affected sites were the femur (n?=?4), humerus (n?=?2), tibia (n?=?3), and ilium (n?=?1). Five cases had received previous surgery and 5 cases had no history of surgery. No patients had been given prior irradiation treatment. For the 5 cases with surgery, radiographs and CT showed purely osteolytic lesions with poor margination in the curettage area (n?=?5), cortical destruction (n?=?5), obvious soft tissue mass (n?=?1), and mineralization (n?=?2). For the 5 cases without surgery, radiographs and CT identified poorly marginated, osteolytic lesions within or near the area with "ground-glass" opacity (n?=?4), cortical erosion (n?=?4), and mineralization (n?=?2). Magnetic resonance imaging (MRI) also identified lesions with heterogeneous signal intensity and pronounced enhancement. Bone scintigraphy revealed eccentric increased uptake of radionuclide in monostotic lesion (n?=?10). Pathology reports revealed osteosarcoma (n?=?7), fibrosarcoma (n?=?2), and malignant fibrous histiocytoma (MFH) (n?=?1). At the end of the study, 1 patient died from tumors, 1 patient was alive with lung metastasis, 1 patient experienced recurrence, and 7 patients were alive without recurrence.Patients with FD and a history of surgery should be followed up, for the osteolytic lesions in the operative areas strongly indicate the malignant transformation. The radiographic feature of FD-related malignancies is poorly marginated, mineralized, and osteolytic lesions with cortical destruction. Further investigations are needed to explore the pathogenesis of malignancies in FD and to establish optimal therapeutic strategies. PMID:25621678

Qu, Nan; Yao, Weiwu; Cui, Xiaojiang; Zhang, Huizhen

2015-01-01

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Malignant solitary fibrous tumor in anterior mediastinum with pleural metastasis simulating invasive thymoma  

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Malignant solitary fibrous tumor, which arises in the anterior mediastinum, is rare. Its image findings simulate other mediastinal mass, such as malignant lymphoma, malignant thymic epithelial tumor or invasive thymoma. Here, we report a pleural malignant fibrous tumor of a 60 year old man who is presented with a well defined lobulating anterior mediastinal mass with pleural metastasis mimicking invasive thymoma with pleural seeding

95

Malignant solitary fibrous tumor in anterior mediastinum with pleural metastasis simulating invasive thymoma  

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Malignant solitary fibrous tumor, which arises in the anterior mediastinum, is rare. Its image findings simulate other mediastinal mass, such as malignant lymphoma, malignant thymic epithelial tumor or invasive thymoma. Here, we report a pleural malignant fibrous tumor of a 60 year old man who is presented with a well defined lobulating anterior mediastinal mass with pleural metastasis mimicking invasive thymoma with pleural seeding.

Kim, Jong Bum; Lee, Ju Won; Kim, Youn Jeong; Kim, Yeo Ju; Lee, Kyung Hee; Chu, Young Chae; Song, Ju Young; Yoon, Yong Han [Inha Univ. School of Medicine/Inha Univ. Hospital, Incheon (Korea, Republic of)

2012-05-15

96

Reconstruction of the pelvic ring using an autologous free non-vascularized fibula graft in a patient with benign fibrous histiocytoma  

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Full Text Available Abstract Background Benign fibrous histiocytomas (BFH usually presents as a small benign lesion that predominantly occurs in the skin. Only few cases of BFH arising from bone have been reported, its occurrence in pelvic bones is even rarer. Case presentation A 34-year-old female presented with BFH at a rare anatomical location on both sides of the os ilium which was larger than earlier reported BFH of the bone. Surgical resection was performed successfully including resection of the inner pelvic ring and reconstruction of the linea terminalis using a non-vascularized fibular autograft. At 18 months after tumor resection and reconstruction of the pelvic ring, with interposition of a free vascularized fibula graft patient has an excellent clinical oncological and functional outcome. Conclusion Non vascularized fibular autograft is a useful reconstructive procedure in select patients.

Werner Mathias

2004-11-01

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Malignant transformation of fibrous dysplasia. A case report and review of the literature.  

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A 34-year-old man developed a spindle-cell sarcoma originating in a preexisting lesion of monostotic fibrous dysplasia. A review of the literature reveals 83 cases of a malignant degeneration in fibrous dysplasia; osteosarcoma was the most common type of tumor. The next most common were fibrosarcoma and chondrosarcoma. The malignant tumor usually developed in the third or fourth decade of life. The most frequent anatomic sites were the craniofacial bones, the femur, and the tibia. Twenty-three of the 83 cases were treated with local radiation. In fibrous dysplasia, any abrupt alteration in the clinical course, manifested by pain and swelling, raises the possibility of malignant degeneration. PMID:3277758

Yabut, S M; Kenan, S; Sissons, H A; Lewis, M M

1988-03-01

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De novo malignant solitary fibrous tumor of the kidney  

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Abstract The kidney is a relatively infrequent site for solitary fibrous tumor (SFT). Among the previously reported cases, only two cases of malignant renal SFT developing via dedifferentiation from a pre-existing benign SFT have been reported. Here we reported a case of de novo malignant renal SFT clinically diagnosed as renal cell carcinoma in a 50-year-old woman. The tumor was circumscribed but unencapsulated and showed obvious hemorrhagic necrosis. Microscopically, the ...

Chen Siu-Chung; Chen Wen-Hsiang; ChangChien Yi-Che; Hsieh Tsan-Yu; Chang Liang-Che; Hwang Cheng-Cheng; Chein Hui-Ping; Chen Jim-Ray

2011-01-01

99

Primary malignant mesenchymoma of bone  

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Full Text Available Pimary malignant mesenchymoma of bone (PMMB is an exceedingly rare neoplasm consisting of two or more unrelated malignant mesenchymal components other than fibrosarcoma or malignant fibrous histiocytoma. Review of the literature reports only 16 cases, most of which were composed of osteosarcoma and liposarcoma. We report a case af PMMB composed of liposarcoma,rhabdomyosarcoma and high grade chondrosarcoma arising within the left distal femur in a 52-year-old male, resulting in the patient's death 3 months after presentation. (Med J Indones 2001;10: 235-41Keywords: Bone tumor-malignancy, liposarcoma, dedifferentiated chondrosarcoma, rhabdomyosarcoma

Errol U. Hutagalung

2001-11-01

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Peritoneal mesothelioma and malignant lymphoma in mice caused by fibrous zeolite.  

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Dust from the village of Karain containing the fibrous zeolite erionite, talc, and physiological saline were tested by intraperitoneal injection in 486 Swiss albino mice. Malignant tumours were found in 84 (41 mesotheliomas, 31 lymphomas, 1 peripheral epidermoid carcinoma, and 11 lymphomas and mesotheliomas together) of the 321 animals which died spontaneously within nine to 32 months after injection of Karain dust (26.1%). Three mesotheliomas and no lymphomas were found among 24 animals inje...

Ozesmi, M.; Patiroglu, T. E.; Hillerdal, G.; Ozesmi, C.

1985-01-01

 
 
 
 
101

An Aggressive Solitary Fibrous Tumor with Evidence of Malignancy: A Rare Case Report  

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Solitary fibrous tumor (SFT) is rare mesenchymal neoplasm that has been originally and most often documented in the pleura. Recently, the ubiquitous nature of the SFT has been recognized with reports of involvement of numerous sites all over the body, i.e, upper respiratory tract, breast, somatic tissue, mediastinum, head, and neck, etc. The diagnosis of SFT still remains an enigma in our field. Furthermore, malignant SFT is extremely rare and only two cases have been reported in the oral cav...

Vimi, S.; Punnya, V. A.; Kaveri, H.; Rekha, K.

2008-01-01

102

Pelvic limb-salvage surgery for malignant tumors  

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Thirteen patients with primary malignant tumors of the pelvis underwent internal hemipelvectomy. The diagnoses were: Ewing's sarcoma 7, osteosarcoma 4, chondrosarcoma 1, and malignant fibrous histiocytoma 1. No megaprostheses or massive allografts were used for reconstruction. Six patients underwent resection only with no reconstruction, 5 had strut grafts inserted to restore the pelvic ring, 1 had an autoclaved autograft of the acetabulum and 1 had an ilio-femoral arthrodesis. No patients we...

Pant, R.; Moreau, P.; Ilyas, I.; Paramasivan, O. N.; Younge, D.

2000-01-01

103

Malignant mesenchymatous tumor of the abdominal cavity  

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Full Text Available SUMMARY Malignant fibrous histiocytoma (MFH represents a soft tissue sarcoma originating from fibroblast cells, and is characterized by a high rate of metastasis or recurrence. The development of this tumor in the gastrointestinal tract is a very rare entity. No more than 30 cases are described in the litrature. We report on a case of such tumor of the abdominal cavity in a 45 year-old woman, presented with epigastric pain, anorexia and weight loss. The CT-scanning revealed the presence of multiple solid tumors in the peritoneal cavity. On the exploratory laparotomy at least 15 solid whitish tumors were found, attached to the wall of the small intestine, as well as to the parietal peritoneum. In addition, there were three metastases revealed in the liver. All tumors were excised; most of them were about 10 cm in diameter. The histopathologic study indicated the presence of a stromal tumor consisting of spindle cells. The consequent immuno- histo-chemical examination of the resected specimens established the definite diagnosis of a pleomorphic malignant fibrous histiocytoma. The postoperative course of the patient was uneventful. She received adjuvant chemotherapy and is still alive and in good health two years later. Key words: malignant fibrous histiocytoma, soft tissue tumors, stromal tumors, sarcomas, storiform-pleomorphic lesions.

K.S. Atmatzidis, T.E. Pavlidis, I.N. Galanis, B.T. Papaziogas, T.B. Papaziogas

2007-03-01

104

Unexpected finding of elevated glucose uptake in fibrous dysplasia mimicking malignancy: contradicting metabolism and morphology in combined PET/CT  

International Nuclear Information System (INIS)

Fibrous dysplasia is a common benign disorder of bone in which fibro-osseous tissue replaces bone spongiosa. Lesions have a typical appearance on computed tomography (CT) images and regularly show a markedly increased uptake in bone scintigraphy using 99mTc-labelled methylene diphosphonate (99mTc-MDP) as radiotracer. The glucose avidity of these lesions depicted by positron emission tomography (PET) using the radiolabelled glucose derivative 18F-fluoro-2-deoxy-glucose (FDG) is less well known since FDG-PET does not have a role in the assessment of this disease. However, single cases have been reported in which fibrous dysplasia was present in patients undergoing FDG-PET scanning for oncological reasons, and no significant FDG uptake was observed for lesions identified as fibrous dysplasia. We report on a 24-year-old man with known fibrous dysplasia who underwent combined FDG-PET/CT scanning because of suspected recurrence of testicular cancer. In contrast to prior reports, a markedly elevated uptake of FDG was seen in numerous locations that were identified as fibrous dysplasia by CT. Based on this result, we conclude that fibrous dysplasia may mimick malignancy in FDG-PET and that coregistered CT may help to resolve these equivocal findings. (orig.)

105

CT findings in malignant pleural mesothelioma related to nonoccupational exposure to asbestos and fibrous zeolite (erionite)  

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Endemic malignant pleural mesothelioma (MPM) in Turkey is related to two mineral fibers, tremolite asbestos and fibrous zeolite (erionite). Thirteen cases of MPM from the Cappadocian area, where the soil is rich in erionite, and 29 cases of MPM, from villages whose occupants have high asbestos exposure, were examined by CT. The CT findings of the two groups of MPM were compared with respect to the configuration of the pleural lesions, stage of disease, fissural involvement, pleural effusion, presence of calcified pleural plaques, and chronic fibrosing pleuritis. In erionite-related MPM the pleural lesions were flat and smooth in 69.1%; in asbestos-related MPM the lesions were nodular in 55.1%. Stage IV disease, calcified pleural plaques, and chronic fibrosing pleuritis were more common in the erionite-related MPM. The rest of the findings were similar in both groups. The early radiological diagnosis of erionite-related MPM may be even more difficult because of the similarity of the pleural lesions to chronic fibrosing pleuritis

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CT findings in malignant pleural mesothelioma related to nonoccupational exposure to asbestos and fibrous zeolite (erionite).  

Science.gov (United States)

Endemic malignant pleural mesothelioma (MPM) in Turkey is related to two mineral fibers, tremolite asbestos and fibrous zeolite (erionite). Thirteen cases of MPM from the Cappadocian area, where the soil is rich in erionite, and 29 cases of MPM, from villages whose occupants have high asbestos exposure, were examined by CT. The CT findings of the two groups of MPM were compared with respect to the configuration of the pleural lesions, stage of disease, fissural involvement, pleural effusion, presence of calcified pleural plaques, and chronic fibrosing pleuritis. In erionite-related MPM the pleural lesions were flat and smooth in 69.1%; in asbestos-related MPM the lesions were nodular in 55.1%. Stage IV disease, calcified pleural plaques, and chronic fibrosing pleuritis were more common in the erionite-related MPM. The rest of the findings were similar in both groups. The early radiological diagnosis of erionite-related MPM may be even more difficult because of the similarity of the pleural lesions to chronic fibrosing pleuritis. PMID:1848247

Erzen, C; Eryilmaz, M; Kalyoncu, F; Bilir, N; Sahin, A; Baris, Y I

1991-01-01

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Renal malignant solitary fibrous tumor with single lymph node involvement: report of unusual metastasis and review of the literature  

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Full Text Available Ettore Mearini,1 Giovanni Cochetti,1 Francesco Barillaro,1 Sonia Fatigoni,2 Fausto Roila2 1Department of Medical-Surgical Specialties and Public Health, Division of Urological Andrological Surgery and Minimally Invasive Techniques, University of Perugia, Terni, Italy; 2Medical Oncology, S Maria Hospital, Terni, Italy Abstract: Solitary fibrous tumors are rare mesenchymal spindle cell neoplasms that are usually found in the pleura. The kidneys are an uncommon site and only few cases of renal solitary fibrous tumor exhibit malignant behavior metastasizing to the liver, lung, and bone through the hematogenous pathway. Purpose: To describe the first case of lymph node metastasis from renal solitary fibrous tumor in order to increase the knowledge about the malignant behavior of these tumors. Patients and methods: A 19-year-old female patient had intermittent hematuria for several months without flank pain or other symptoms. A chest and abdomen CT scan was performed and showed a multi-lobed bulky solid mass of 170 × 98 × 120 mm in the left kidney. One day before the surgery, the left renal artery was catheterized and the kidney embolization was performed using a Haemostatic Absorbable Gelatin Sponge and polyvinyl alcohol. We then performed a radical nephrectomy with hilar, para-aortic, and inter-aortocaval lymphadenectomy. Results: Estimated intraoperative blood loss was 200 mL and the operative time was 100 minutes. No postoperative complications occurred. The hospital stay was 7 days long. The histological examination was malignant solitary fibrous tumor of the kidney. Cancerous tissue showed cellular atypia, with an increased mitotic index (up to 7 × 10 hpf. Immunohistochemical analysis showed positive results for CD34, BCL2, partial expression of HBME1, and occasionally of synaptophysin. Histological evaluation confirmed the presence of metastasis in one hilar node. The patient did not receive any other therapy. At 30-month follow-up, the patient was in good health and no local recurrence or metastases had occurred. Conclusion: This is the first case of lymph node metastasis from a renal solitary fibrous tumor showing unusual malignant behavior; this finding adds new information about the biology and progression of these tumors, which remain unclear. Keywords: solitary fibrous tumor, sarcoma, kidney, lymph node metastases, lymphadenectomy

Mearini E

2014-05-01

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Skull base metastases from a malignant solitary fibrous tumor of the liver. A case report and literature review  

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Full Text Available Abstract Solitary fibrous tumors (SFTs of the liver are rarely described; only 38 cases have been reported in literature, most of which have shown benign clinical characteristics, and only 3 of these cases exhibited malignant variants. In this study, we present a 24-year-old woman with a 1-month history of a rapidly enlarging abdominal mass and a CT showing an exophytic heterogeneous liver mass with a firm parietal bone mass. The patient underwent a transcatheter arterial chemoembolization (TACE before operation, and an extended right hepatectomy and craniectomy with a negative margin was performed under general anesthesia. The masses showed histological features of oval spindle cells haphazardly arranged in the classic short-storiform or so-called patternless pattern of solitary fibrous tumors. The tumor cells showed positive immunohistochemical reactions to CD34 and bcl-2. The tumor recurred in the residual liver 2 months after operation, metastatic osteoblastic lesions in the thoracic and lumbar vertebrae were identified 3 months after the operation, and lumbar vertebrae metastasis 7 months after operation paralyzed the patient. The patient underwent percutaneous ethanol injection therapy (PEI and chemotherapy, but the patient died because of the uncontrolled tumor 16 months after the initial operation. To our knowledge, this is the first case of malignant solitary fibrous liver tumors with skeletal metastasis.

Peng Lu

2011-12-01

109

CT of malignant soft tissue tumor  

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CT provides excellent anatomic detail of soft tissue tumors and precise location, size, extent of the tumor and its effect on adjacent organs. We evaluated CT findings of 13 cases of soft tissue tumors which proven pathologically during recent 4 years. There were 7 cases of liposarcoma, 4 cases of rhabdomyosarcoma, one of leiomyosarcoma and one case of malignant fibrous histiocytoma. CT was often characteristic to diagnose specific histology of soft tissue tumor. Well differentiated liposarcoma showed predominant fat density with internal septation. Rhabdomyosarcoma in children showed inhomogeneous density and peripherally enhanced rim.

110

Malignant mesenchymatous tumor of the abdominal cavity  

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SUMMARY Malignant fibrous histiocytoma (MFH) represents a soft tissue sarcoma originating from fibroblast cells, and is characterized by a high rate of metastasis or recurrence. The development of this tumor in the gastrointestinal tract is a very rare entity. No more than 30 cases are described in the litrature. We report on a case of such tumor of the abdominal cavity in a 45 year-old woman, presented with epigastric pain, anorexia and weight loss. The CT-scanning revealed the presence of m...

K S Atmatzidis, T. E. Pavlidis

2007-01-01

111

67Ga scintigram and MRI in malignant bone tumors and malignant soft tissue tumors  

International Nuclear Information System (INIS)

We have analyzed the characteristics of 67Ga scintigram and MRI in 11 malignant bone tumors and 11 malignant soft tissue tumors. Osteosarcoma showed a high accumulation in 67Ga scintigram and low signal intensity in T1 weighted image. T2 weighted images were not characteristic. Chondrosarcoma showed medium 67Ga accumulation and low signal in T1 weighted image and high signal in T2 weighted image. Ewing sarcoma showed low accumulation in 67Ga scan and medium intensity in MRI. Malignant soft tissue tumors showed rather low 67Ga accumulation compared with malignant bone tumors. Malignant fibrous histiocytoma showed medium accumulation of 67Ga, low signal in T1 weighted image and high signal in T2 weighted image. Liposarcoma showed low 67Ga accumulation and medium signal in T1 weighted image and high signal in T2 weighted image. To summarize these characteristics, three dimensional display is demonstrated. (author)

112

Malignant neoplastic emboli to the coronary arteries: report of two cases and review of the literature.  

Science.gov (United States)

Two patients were seen with malignant neoplastic emboli to the coronary arteries. One, a 61-year-old woman with a malignant fibrous histiocytoma of the thigh and a solitary pulmonary metastatic lesion, died of an acute myocardial infarction due to a neoplastic coronary embolus after lobectomy. The other, a 51-year-old woman with bronchogenic adenocarcinoma, died of extensive cerebral metastases. At autopsy, she also was found to have had an acute myocardial infarction associated with a neoplastic coronary embolus. PMID:3623554

Ackermann, D M; Hyma, B A; Edwards, W D

1987-09-01

113

Aneurysmal dermatofibroma mimicking both clinical and dermoscopic malignant melanoma and Kaposi's sarcoma.  

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Aneurysmal dermatofibroma (AD) or aneurysmal fibrous histiocytoma (AFH) is a relatively rare form of histiocytoma representing less than 2% of total cases. It shares many clinical and dermoscopic similarities with skin tumors, especially malignant melanoma and Kaposi's sarcoma, which can make differentiation problematic. We report the case of a 53-year-old man, who presents with a black nodular tumor with increased consistency, edges infiltrated from the surface to depth, spontaneous and sensitive to touch that shows rapid growth in the last three months. Dermoscopically, the central region consists of intricate areas colored in red, violet, blue-white and black. On the periphery stand two rings, centrally white and peripherally pigmented, with an abundance of polymorphic capillaries. To clarify the diagnosis, the lesion was widely excised and histopathological examination was performed, which revealed immunophenotypical tumor cells negative for HMB-45 and S100, and numerous CD68 macrophages between tumor cells. This aneurysmal fibrous histiocytoma shows both clinical and dermoscopically discrete differential criteria, which are not specific and that make it difficult to distinguish from malignant melanoma and Kaposi's sarcoma, and required performing histopathology and immunohistochemistry. PMID:25607410

Morariu, Silviu Horia; Suciu, Mircea; Vartolomei, Mihai Dorin; Badea, Mihail Alexandru; Cotoi, Ovidiu Simion

2014-01-01

114

Primary malignant bone tumors: diagnosis, radiological appearance and therapy; Primaer maligne Knochentumoren: Klinik und Therapie  

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Diagnosis, concepts of therapy and prognosis of primary malignant bone tumors require intensive cooperation between orthopedic surgeons, radiologists and pathologists with special knowledge in oncology. The present paper demonstrates relevant topics of diagnosis, radiological appearance and therapy of the osteosarcoma, Ewing`s sarcoma, chondrosarcoma and malignant fibrous histiocytoma based on the material of the Vienna Bone Tumor Registry and more than 35 years of cooperation between the Institute of Pathology and Anatomy and the Department of Orthopedics at the University of Vienna. (orig.) [Deutsch] Fuer die Diagnose, Therapieplanung und Prognosebeurteilung von primaer malignen Knochentumoren ist eine intensive Kooperation von onkologisch speziell ausgebildeten Fachdisziplinen wie Orthopaedie, Radiologie und Pathologie erforderlich. Die vorliegende Arbeit basiert auf dem Material des Wiener Knochengeschwulstregisters und der 35jaehrigen Zusammenarbeit des Pathologisch/Anatomischen Instituts der Universitaet Wien mit der Universitaetsklinik fuer Orthopaedie und beschreibt Diagnose, radiologisches Erscheinungsbild und Therapie der 4 haeufigsten primaer malignen Knochentumoren: Osteosarkom, Ewing`s Sarkom, Chondrosarkom und malignes fibroeses Histiozytom. (orig.)

Dominkus, M.; Kotz, R. [Universitaetsklinik fuer Orthopaedie, Wien (Austria); Kainberger, F. [Abt. fuer Osteoradiologie, Universitaetsklinik fuer Radiologie, Wien (Austria); Lang, S. [Wien Univ. (Austria). Universitaetsklinik fuer Pathologische Anatomie

1998-06-01

115

CT findings of malignant soft tissue tumors in the extremities  

International Nuclear Information System (INIS)

The CT findings in 12 cases of malignant soft tissue tumors in the extremities and buttocks were analyzed. All cases were verified as malignant either histologically or cytologically. Eight cases out of 12 were Malignant Fibrous Histiocytoma. On CT, the majority of tumors appeared relatively well defined mass with lower attenuation areas representing necrosis. Compared with muscle, majority of tumors were slightly hypodense on plain CT, and were enhanced markedly after contrast injection. CT provided valuable informations to demonstrate the relation of tumor to surrounding structures, central necrosis, calcification, which were important in differential diagnosis. We concluded that CT findings combined with clinical informations were useful in differential diagnosis of malignant soft tissue tumors. (author)

116

Doege-Potter syndrome presenting with hypoinsulinemic hypoglycemia in a patient with a malignant extrapleural solitary fibrous tumor: a case report  

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Full Text Available Abstract Introduction Doege-Potter syndrome is a paraneoplastic syndrome characterized by non-islet cell tumor hypoglycemia secondary to a solitary fibrous tumor. This tumor causes hypoglycemia by the secretion of a prohormone form of insulin-like growth factor II. We describe the diagnosis and management of Doege-Potter syndrome and the use of transarterial chemoembolization in a patient with a malignant extrapleural solitary fibrous tumor. Case presentation Our patient was a 64-year-old Caucasian woman who initially presented with urinary incontinence and was found to have a 14.5×9.0×9.0cm retroperitoneal solitary fibrous tumor compressing her bladder. Her tumor was surgically resected but recurred with multiple hepatic metastatic lesions. The hepatic metastases progressed despite systemic chemotherapy and treatment with doxorubicin transarterial chemoembolization. Her course was complicated by the development of recurrent fasting hypoglycemia, most likely secondary to Doege-Potter syndrome. Her hypoglycemia was managed with corticosteroid therapy and frequent scheduled nutrient intake overnight. Conclusions The rarity of hepatic solitary fibrous tumors and consequent lack of controlled trials make this report significant in that it describes the diagnostic approach to Doege-Potter syndrome, describes our experience with the use of doxorubicin transarterial chemoembolization, and presents management options for tumor-associated hypoglycemia in the case of extensive disease not amenable to surgical resection.

Schutt Robert C

2013-01-01

117

Ionizing radiation induced malignancies in man  

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Using data on gene and chromosome alterations in human cancers, it is proposed that most radiation induced cancers are a consequence of recessive mutations of tumor suppressor genes. This explains the long delay between radiation exposure and the cancer onset. As a consequence, radiation induced cancers belong to groups of tumors where no specific translocations (forming or activating oncogenes) but multiple unbalanced chromosome rearrangements (deletions unmasking recessive mutations) exist. This explains why osteosarcomas, malignant fibrous histiocytoma, chondrosarcomas are frequently induced, but not liposarcoma, Ewing sarcomas and rhabdomyosarcomas, among others. A single exception confirms this rule: papillary thyroid cancer, frequently induced in exposed children, in which structural rearrangements frequently form a RET/PTC3 fusion gene. This fusion gene is the results of the inversion of a short segment of chromosome 10, and it is assumed that such rearrangement (small para-centric inversion) can easily occur after exposure to radiations, at contrast with translocations between to genes belonging to different chromosomes. (author)

Dutrillaux, B. [CEA Fontenay-aux-Roses, 92 (France). Dept. de Radiobiologie et de Radiopathologie

1997-03-01

118

Diagnostic pitfalls in the preoperative 18F-FDG PET/CT evaluation of a case of giant malignant solitary fibrous tumor of the pleura.  

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Solitary fibrous tumor of the pleura (SFTP) is an uncommon entity, generally with an indolent behavior. Nevertheless, some malignant forms have been rarely reported. These, often have an aggressive biological behavior with pathological findings of invasiveness. The preoperative diagnosis and evaluation of the grade of malignancy are extremely challenging. Herein we report a case of a 64-year-old man who presented with a left giant intra-thoracic mass imaged with fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG/PET-CT) and sampled via fine-needle aspiration biopsy (FNAB). Imaging and FNAB findings showed suspicion of a benign form of SFTP. Surgical radical resection of the giant mass was performed. The definitive histological diagnosis showed a malignant SFTP. Based on this report, we take the opportunity to briefly discuss the insidious pitfalls concerning the radiological and (18)F-FDG/PET-CT features as well as cyto/histological findings in the pre-operative diagnostic work-up examination of this rare entity. PMID:24079956

Lococo, F; Rapicetta, C; Ricchetti, T; Cavazza, A; Filice, A; Treglia, G; Tenconi, S; Paci, M; Sgarbi, G

2014-01-01

119

Accumulation of leucocytes labelled with technetium-99m hexamethylpropylene amine oxime in malignant abdominal tumours  

International Nuclear Information System (INIS)

A total of 343 leucocyte scans labelled with technetium-99m hexamethylprophylene amine oxime were reviewed that had been performed patients suspected of having abdominal infection or inflammation. There was uptake by malignant abdominal tumours in 10 cases (2,9%), which represents 62.5% of known malignancies at the time of the scintigram. Accumulation was seen in 8 patients with adenocarcinoma of the colon associated with a secondary infection in the tumour or pericolic inflammation. A large tumour that had spread beyond the bowel wall was related to a positive scintigram. Accumulation was also found twice in a malignant fibrous histiocytoma in which bleeding and an inflammatory reaction to necrosis were probably responsible for the uptake. The relevant treatment was delayed for 2 weeks-2 months in 4 patients with adenocarcinoma of the colon in whom the positive uptake was regarded as confirmation of the clinically suspected cute diverticulitis. (orig.)

120

Subungual Acral Fibromyxoma Involving the Bone: A Mimicker of Malignancy.  

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: Superficial acral fibromyxoma (SAF) is a recently recognized myxoid tumor that usually occurs on the fingers and toes of middle-aged adults. We report the case of a 53-year-old man with a SAF on the first left toe that had been slowly growing for 2 years. Hispathologically, the lesion was nonencapsulated and was composed of stellate and spindle cells, arranged in a myxoid matrix. No atypia or mitotic figures were found. Neoplastic cells showed positive staining for CD34 and negative staining for epithelial membrane antigen, actin, desmin, keratins, S-100 protein, and HMB45. Main differential diagnoses of SAF include benign and malignant myxoid and spindle cells tumors, such as myxoid fibrous histiocytoma, superficial angiomyxoma, myxoid neurofibroma, myxoid dermatofibrosarcoma protuberans, and low-grade fibromyxoid sarcoma. PMID:25062265

Carranza, Carmen; Molina-Ruiz, Ana María; Pérez de la Fuente, Teresa; Kutzner, Heinz; Requena, Luis; Santonja, Carlos

2014-07-24

 
 
 
 
121

Diabetic fibrous mastopathy.  

Science.gov (United States)

Diabetic fibrous mastopathy is an uncommon self-limiting fibroinflammatory diseae of the breast that is seen predominantly in premenopausal women with long standing type I (insulin dependent) diabetes mellitus. In this report, we present a 29 years old female with uncontrolled diabetes mellitus presenting with bilateral breast masses which were irregular and hypoechoic on ultrasound, gradual enhancement on MRI and diagnosed as diabetic fibrous mastopathy on histopathology. It is quite difficult to distinguish it from malignancy on mammographic and ultrasonographic features or clinical findings. Correlation of the pathological features may help to make the correct diagnosis for this disease. PMID:24717992

Gunduz, Yasemin; Tatli, Lacin; Kara, Rabia Oztas; Cakar, Gozde Cakirsoy; Akdemir, Nermin; Dilek, Fatma Hüsniye

2014-03-01

122

Spontaneous malignant transformation of conventional giant cell tumor  

International Nuclear Information System (INIS)

Spontaneous malignant transformation of conventional giant cell tumor (GCT) of bone is exceedingly rare. We report on a case of GCT of the iliac crest in a 35-year-old woman with malignant change into a high-grade osteosarcoma 10 years after the first appearance of GCT on a radiograph. Since the patient refused therapy for personal reasons the tumor remained untreated until sarcomatous transformation occurred. Image cytometry showed DNA aneuploidy and a suspiciously high 2c deviation index (2cDI) in the primary bone lesion. A thorough review of the world literature revealed only seven fully documented cases of secondary malignant GCT which matched the definition of a ''sarcomatous growth that occurs at the site of a previously documented benign giant cell tumor'' and not treated by radiotherapy. These cases as well as the current one suggest that a spontaneous secondary malignant GCT presents as a frankly sarcomatous tumor in the form of an osteosarcoma or malignant fibrous histiocytoma. It usually appears at sites of typical GCTs - often without any recurrent intermediate state - and is diagnosed 3 or more years after the primary bone lesion. The prognosis is poor. (orig.)

123

A Solitary Fibrous Tumor with Giant Cells in the Lacrimal Gland: A Case Study  

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Orbital solitary fibrous tumor (SFT) has recently been proposed as the encompassing terminology for hemangiopericytoma, giant cell angiofibroma (GCAF), and fibrous histiocytoma of the orbit. The lacrimal gland is a very rare location for both SFT and GCAF. A 39-year-old man presented with a painless left upper eyelid mass. An orbital computed tomography scan identified a 1.1 cm-sized well-defined nodule located in the left lacrimal gland. He underwent a mass excision. Histopathologic examinat...

Son, Da Hye; Yoo, Su Hyun; Sa, Ho-seok; Cho, Kyung-ja

2013-01-01

124

The Study of the Malignant Tumors of the Maxillary Sinus by Computed Tomography  

International Nuclear Information System (INIS)

CT findings of proven 25 malignant tumors of the maxillary sinus were retrospectively analyzed to be of help in the diagnosis and treatment. The results were as follow: 1. Average age was 54 years old, and eighteen were males and seven were females with a ratio of 2.6:1. 2. The most common histopathologic feature was squamous cell carcinoma (19 cases) and others were two cases of adenoid cystic carcinoma, one case of malignant fibrous histiocytoma, mucoepidermoid tumor, histiocytic lymphoma, unidentified malignant tumor. 3. CT findings were sinus opacification (4%), soft tissue mass (92%), low densities within soft tissue mass (44%), air densities within soft tissue mass (24%), osteosclerosis (4%), bone destruction (92%), bone displacement (32%), fat plane obliteration(76%). 4. CT in the malignant maxillary sinus tumors approved the value in evaluation of tumor extension to nasal cavity, ethmoid sinus, orbit, infratemporal fossa, pterygopalatine fossa, pterygoid fossa, pterygoid muscle, cheek skin and intracranial cavity. 5. Twenty four cases (96%) were stage III, stage IV according to AJCC TNM classification. 6. Bone findings were destruction, displacement, sclerosis and most frequent site of bone destruction was the medial wall of the antrum (92%). 7. Tumor growth pattern showed destructive pattern in 18 cases (72%), and squamous cell carcinoma showed destructive pattern. (p<0.05).

125

Diagnostic significance of MRI in malignant skin tumors  

International Nuclear Information System (INIS)

For surgical treatment of malignant tumors, it is important to clarify the depth and area of invasion of tumors and the relation to surrounding normal tissues such as adipose tissue, muscles and bones in addition to the histological diagnosis of the tumors before operation. For this purpose we clinically evaluated a magnetic resonance imaging (MRI) for diagnosing skin tumors. A MRI, SIGNA (GE), which analyzes the tumors by a spin echo method (TR 1500, TE 20) was used in this study, and 29 slices of MRI in a tumor were accumulated crossing those tumors. The usefulness of three dimensional presentation of skin tumors performed by the MRI data was also discussed. For three dimensional presentation, VoxelflingerTM was applied and those images were compared with cross section of those tumors during operation and histological specimens. We applied the MRI examination on patients with malignant melanoma, malignant fibrous histiocytoma, fibrosarcoma and squamous cell carcinoma of skin. The MRI was a very useful tool to clarify the depth and area of invasion of malignant tumors and the relation to surrounding normal tissues. The effects of MRI was most remarkable when applied on patients with malignant melanoma of soles. Three dimensional presentation obtainned from the MRI data was also useful to know three dimensional condition of those tumors but it seems still to have limitation because of the analytical software of the computer. In conclusion, we suggest that Mcomputer. In conclusion, we suggest that MRI should be the imaging modality of choice in evaluating skin tumors especially of the extremities, and three-dimensional analysis will be beneficial as well as that of using slice images in the future. (author)

126

Soft tissue giant cell tumour of low malignant potential: a rare tumour at a rare site.  

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"Soft tissue giant cell tumour of low malignant potential" is considered as the soft tissue counterpart of osteoclastoma of the bone. It is a primary soft tissue tumour which is classified under the category of fibrohistiocytic tumours of intermediate malignancy.Seventy percent of the tumours involve the extremities and only about seven percent of them arise in head and neck region. They are composed of nodules of histiocytes in a vascular stroma, with multinucleated osteoclast-like giant cells positive for vimentin, smooth muscle actin (SMA), CD68 and Tarterate Resistant Acid Phosphatase (TRAP). We are presenting a case of a 75-year-old man who had a nodule on the ala of the nose. Histopathology showed a histiocytic lesion. Benign fibrous histiocytoma, plexiform fibrohistiocytic tumour, solitary reticulohistiocytoma and histioid leprosy were ruled out by using special stains and immunostains. Expression of smooth muscle actin and CD68 confirmed the diagnosis of a soft tissue giant cell tumour with a low malignant potential. PMID:24551690

Bhat, Amoolya; V, Geethamani; C, Vijaya

2013-12-01

127

Vena cava replacement for malignant disease: is there a role?  

Science.gov (United States)

Resection and graft replacement of the vena cava for malignant disease is rarely performed, often because of the advanced tumor stage. Since August 1987 we have selectively performed caval replacement in conjunction with tumor resection in 11 patients. Three patients had superior vena cava reconstruction (SVCR) and eight had inferior vena cava replacement (IVCR). There were six males and five females whose mean age was 59.3 years (range 24 to 75 years). Two patients, each with superior vena cava obstruction, presented with symptoms from venous compression. Malignancies involving the superior vena cava were thyroid carcinoma in two patients and lymphoma in one. Cancers requiring IVCR were leiomyosarcoma in three patients, cholangiocarcinoma in two, and malignant fibrous histiocytoma, hepatocellular carcinoma, and colon carcinoma metastatic to the liver in one each. All IVCRs and two SVCRs were performed with expanded polytetrafluoroethylene grafts. The remaining SVCR was constructed with spiral saphenous vein. Six IVCRs involved replacement of the retrohepatic inferior vena cava in conjunction with major liver resection. Mean intraoperative blood transfusions were 5.3 units (range 0 to 10 units). There were no operative deaths. Complications occurred in four patients and included postoperative bleeding in two, myocardial infarction in one, and wound infection in one. There were no perioperative graft occlusions, but one patient developed graft occlusion 2 months after SVCR. All IVCR grafts have remained patent (mean follow-up of 8.8 months). Two patients with SVCRs have died from recurrent cancer at 3.2 and 3.4 years postoperatively. Six patients with IVCRs have developed tumor recurrence either locally (n = 1), at a distant site (n = 2), or both (n = 3). Importantly, eight of nine survivors have an excellent performance status. We conclude that vena cava reconstruction for malignancy can be performed safely, has few graft-related complications, and in some patients may offer the only possibility for tumor control. PMID:8518120

Bower, T C; Nagorney, D M; Toomey, B J; Gloviczki, P; Pairolero, P C; Hallett, J W; Cherry, K J

1993-01-01

128

Highly malignant soft tissue sarcoma of the extremity with a delayed diagnosis  

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Full Text Available Abstract Purpose To evaluate the characteristics of highly malignant soft tissue sarcoma of the extremity with a delayed diagnosis. Materials and methods The clinical and radiological characteristics of 18 cases of highly malignant soft tissue sarcomas of the extremity with a delayed diagnosis were determined. Results Ten men and eight women of mean age 44.8 years (range, 15-79 years were included in this study. Seven cases of synovial sarcoma, three cases each of alveolar soft part sarcoma and malignant fibrous histiocytoma, two cases each of highly malignant leiomyosarcoma and myxofibrosarcoma, and one case of clear cell sarcoma were enrolled. Times from tumor detection to diagnosis ranged from 1 to 3 years in most cases; three of the seven synovial sarcoma cases took more than 10 years to diagnose. Of the seven cases of synovial sarcoma, five cases of small, superficial located masses were simply excised without a pre-surgical biopsy. Three cases of alveolar soft part sarcoma showed characteristic T1- and T2-weighted high signal intensities with signal voids in MR images. In addition, one synovial sarcoma patient and one alveolar soft part sarcoma patient showed evidence of calcification on plain radiographs. However, no general characteristic clinical findings were found to be common to the 18 cases. Conclusions Contrary to general expectations, some soft tissue tumors that grow slowly are painless, and those that occur in superficial limbs may be highly malignant. Thus, even when a slow growing, painless superficial mass is encountered in a limb, physicians should keep the possibility of highly malignant soft tissue sarcoma in mind.

Chae In

2010-09-01

129

Mesothelioma - benign-fibrous  

Science.gov (United States)

Mesothelioma - benign; Mesothelioma - fibrous; Pleural fibroma; Solitary fibrous tumor of the pleura ... other reasons. Other tests that may show benign mesothelioma include: CT scan of the chest Open lung ...

130

38 CFR 3.309 - Disease subject to presumptive service connection.  

Science.gov (United States)

...larynx, or trachea) Soft-tissue sarcoma (other than...Note 1: The term “soft-tissue sarcoma” includes...Dermatofibrosarcoma protuberans Malignant fibrous histiocytoma...angioendotheliomatosis Malignant glomus tumor Malignant...

2010-07-01

131

Pseudotumoral fibrous dysplasia of the maxilla  

International Nuclear Information System (INIS)

Clinical, radiological, and histological problems arise relating to fibrous dysplasia of the maxilla. Clinically, 11 of our 39 cases developed so rapidly that the lesions were suspected of being malignant. The histological diagnosis may be very difficult, since any tumoural, reactive, or healing process may simulate fibrous dysplasia. As a general rule, the diagnosis is established most easily by the radiological examination. The radiologist's responsibility is important, as mistakes may have serious consequences. We report four pseudotumoural forms of maxillary sinus fibrous dysplasia. All were characterised clinically by rapid evolution, radiologically by opacity of the sinus with apparent destruction of its wall, and histologically by difficulty in establishing the diagnosis. In two cases indeed, the initial histological interpretation was an osteogenic sarcoma. Due to its excellent densitometric resolution, computed tomography provides an invaluable contribution by displaying the fibrous wall of an intact or even thickened maxillary sinus when conventional radiology has suggested a destructive process. In difficult cases of maxillary fibrous dysplasia, computed tomography should be used as a supplementary investigation to establish the correct diagnosis. (orig.)

132

Steel Fibrous Concrete  

International Science & Technology Center (ISTC)

The Construction of Reliable and Durable Structural Units for Energy Facilities, Transportation Facilities and Other Structures Subjected to the Action of a Variety of Conditions and Loads Using New Compound Material - Steel Fibrous Concrete

133

Kinematics of fibrous aggregates  

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This thesis reports on a research into the progressive development of fibrous aggregates, e.g. calcite, quartz and mica crystals in veins and strain fringes. The study is based on microstructural analysis of natural examples and on computer experiments. Investigation of fibrous looking elongate crystals in striped bedding-veins from the Orobic Alps, Italy indicate that these crystals do not track the opening trajectory of the veins but are oriented at an angle of up to 80° to the opening dir...

Ko?hn, Daniel

2000-01-01

134

A case of congenital solitary Langerhans cell histiocytoma.  

LENUS (Irish Health Repository)

A newborn baby boy was referred to the Paediatric Dermatology Unit with a solitary asymptomatic nodule overlying his right nasolabial fold. Complete physical examination, full blood count, serum chemistry, liver function tests and baseline imaging were unremarkable. Histopathological examination showed an atypical dermal infiltrate of mononuclear cells that stained positive with CD1a and S100. A diagnosis of congenital solitary Langerhans cell histiocytoma was made. The lesion completely resolved by 4 months of age. The baby is now 15 months old and repeat systemic evaluation has remained normal.

Ricciardo, Bernadette

2012-02-01

135

Special diagnostic problems in primary malignant bone tumors; Spezielle diagnostische Probleme bei primaer malignen Knochentumoren  

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The diagnosis of primary malignant bone tumors, which only account for 1% of malignancies in humans, represents quite a challange for the pathologist. Apart from the often overlapping morphology between different entities, heterogeneity within one and the same tumor has to be kept in mind. Furthermore, in most cases the diagnosis must be established based on small biopsy specimens and occasionally even on frozen sections. In this context detailed clinical information including the patient`s age and exact localization of the tumor, as depicted by X-ray or MRI, are essential requirements for a correct diagnosis. In addition, multiple biopsies from different tumor sites may be of help. For example, 25% of osteogenic sarcomas (OSA) are chondroplastic. Others may contain areas similar to fibrosarcoma (FSA) or malignant fibrous histiocytoma (MFH). Since 90% of OSA occur in the second decade of life whereas chondrosarcomas, FSA and MFH usually manifest after the age of 40 years, a biopsy solely composed of malignant chondromatous tissue obtained from a tibial lesion of a 10-year-old child should most likely be considered as part of an OSA. In the differential diagnosis of the so-called small, round cell tumors, which include Ewing sarcoma, malignant lymphoma and small-cell OSA, immunohistochemical staining of the paraffin-embedded material and a molecular biological/genetic work-up of frozen material are most helpful. In this paper the histomorphological characteristics and criteria for differential diagnosis of the most common primary malignant bone tumors are discussed. (orig.) [Deutsch] Die Diagnostik primaer maligner Knochentumoren kann dem Pathologen oft grosse Probleme bereiten. Die wichtigsten Voraussetzungen sind eine repraesentative Biopsie, Roentgenunterlagen sowie klinische Informationen bezueglich Alter, Lokalisation des Tumors und Symptomatik. Nicht nur die Vielzahl, sondern auch die histomorphologische Ueberlappungen der Entitaeten koennen zu Fehlinterpretationen Anlass geben. So ist am Biopsiematerial, nicht nur die definitive Entitaetszuordnung, sondern v.a. auch die Unterscheidung von benignen und malignen Prozessen oftmals schwierig. Bei einigen Problemstellungen koennen immunhistochemische Untersuchungen oder Chromosomenanalysen hilfreich sein. Es wird hier ueber die wichtigsten histomorphologischen Kriterien primaer maligner Knochentumoren und deren differentialdiagnostische Abgrenzung, im Biosiematerial bzw. im Schnellschnittbefund berichtet. (orig.)

Lang, S.; Sulzbacher, I. [Wien Univ. (Austria). Klinisches Inst. fuer Klinische Pathologie

1998-06-01

136

Case report 141  

International Nuclear Information System (INIS)

The case reported represents another example of dedifferentiation occurring in a benign cartilaginous tumor of bone. Osteosarcoma and fibrosarcoma are generally considered to represent the more malignant counterparts of such dedifferentiation, but studies recently have indicated that malignant fibrous histiocytoma may indeed be a common feature in such dedifferentiated lesions. It is stressed that lesions previously designated histologically as malignant giant cell tumor, when dedifferentiation occurs, may represent a special variant of malignant fibrous histiocytoma. (orig./MG)

137

Strength of Fibrous Composites  

CERN Document Server

"Strength of Fibrous Composites" addresses evaluation of the strength of a fibrous composite by using its constituent material properties and its fiber architecture parameters. Having gone through the book, a reader is able to predict the progressive failure behavior and ultimate strength of a fibrous laminate subjected to an arbitrary load condition in terms of the constituent fiber and matrix properties, as well as fiber geometric parameters. The book is useful to researchers and engineers working on design and analysis for composite materials. Dr. Zheng-Ming Huang is a professor at the School of Aerospace Engineering & Applied Mechanics, Tongji University, China. Mr. Ye-Xin Zhou is a PhD candidate at the Department of Mechanical Engineering, the University of Hong Kong, China.

Huang, Zheng-Ming

2012-01-01

138

Intraperitoneal Solitary Fibrous Tumor  

Science.gov (United States)

Solitary fibrous tumors of the pelvis are rare. We report the case of a 32-years-old patient who presented with abdominopelvic mass. The imaging studies showed a right adnexal mass of more than 10?cm. Exploratory laparotomy revealed a 20?cm mass at the Douglas pouch which was adhered to the posterior wall of the uterus. Complete resection of the mass was performed. Histological analysis showed a spindle cell undifferentiated tumor whose morphological and immunohistochemical profile are consistent with solitary fibrous tumor. It is important to know that although these tumors are rare, their evolution can be pejorative. Therefore, long-term followup should be recommended. PMID:25276449

Benabdejlil, Youssef; Kouach, Jaouad; Babahabib, Abdellah; Elhassani, Moulay Elmehdi; Rharassi, Issam; Boudhas, Adil; Bakkali, Hicham; Elmarjany, Mohammed; Moussaoui, Driss; Dehayni, Mohamed

2014-01-01

139

Limb-sparing surgery for high-grade malignant tumors of the proximal tibia. Surgical technique and a method of extensor mechanism reconstruction.  

Science.gov (United States)

A surgical technique designed for safe and easy access to the popliteal vessels, resection of a large segment of the tibia and knee joint, and a method of patellar/extensor mechanism reconstruction and soft-tissue coverage that utilizes a transferred medial gastrocnemius muscle is reported. Eleven patients have been treated with this technique, including seven patients with a minimum follow-up evaluation of two years (average, 49.5 months; range, 24.6-84.4 months). There were five males and two females, with an average age of 28.7 years. The histologic diagnoses were osteosarcoma, four patients; malignant fibrous histiocytoma, one patient; chondrosarcoma, one patient; and poorly differentiated sarcoma, one patient. The surgical stages were Stage IIA, one patient, and IIB, six patients. Six intraarticular resections and one extraarticular resection were performed; all were classified as wide excisions. Four prosthetic replacements and three arthrodeses were performed. Pathological specimens showed meniscal and patellar tendon involvement in two patients and pericapsular tibiofibular joint involvement in six patients. Local complications were transient peroneal nerve palsy in four patients and superficial skin slough in one patient. All resections obtained negative margins, and there was no local recurrence or metastatic disease. Functional results (Musculoskeletal Tumor Society System classification) were excellent in one patient, good in four, fair in one, and poor in one. Limb-sparing surgery for high-grade tumors of the proximal tibia is recommended for carefully selected patients. PMID:2536305

Malawer, M M; McHale, K A

1989-02-01

140

Intraarterial Chemotherapy for Extremity Osteosarcoma and MFH in Adults  

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The neoadjuvant treatment of osteosarcoma using intravenous agents has resulted in survival rates of 55% to 77% [3, 5, 6, 20, 22, 35]. We designed a neoadjuvant chemotherapy protocol using combined intraarterial and intravenous agents to treat high-grade osteosarcoma and malignant fibrous histiocytoma of bone in an attempt to improve survival. We report the results of treating 53 adults (age 18–77 years) diagnosed with nonmetastatic extremity osteosarcoma or malignant fibrous histiocytoma....

Hugate, Ronald R.; Wilkins, Ross M.; Kelly, Cynthia M.; Madsen, Walt; Hinshaw, Ioana; Camozzi, Anne B.

2008-01-01

 
 
 
 
141

Phenotypic characterisation of peripheral blood lymphoid cells in people exposed to fibrous zeolite.  

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Among inhabitants of the village of Karain in Turkey there is an extremely high incidence of malignant mesothelioma, most probably due to exposure to erionite, which is a fibrous zeolite and similar in appearance and properties to asbestos. This mineral may be found in the dust in the village. To characterise possible disturbances in the immune system of people exposed to fibrous zeolite, a phenotypic characterisation of lymphoid cells in the peripheral blood of 74 immigrants to Sweden from K...

Ozesmi, M.; Karlsson-parra, A.; Hillerdal, G.; Forsum, U.

1986-01-01

142

Gluteal Congenital Fibrous Hamartoma of Infancy: A Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available Fibrous hamartoma of infancy (FHI is a rare benign subcutaneous tumor which is commonly seen in the first year of life. Patients usually present with a single, painless, rapidly growing mass located mostly on the upper extremities. It can be difficult to distinguish this lesion from the malignant soft tissue sarcomas because of the rapid growth and radiological characteristics. Here we report a 5-month-old boy with a large gluteal mass and cutaneous findings which was initially thought to be an infiltrative malignant tumor and finally diagnosed as FHI. [Cukurova Med J 2013; 38(2.000: 333-337

Begul Yagci-Kupeli

2013-04-01

143

Malignant pleural disease  

Energy Technology Data Exchange (ETDEWEB)

The vast majority of pleural neoplasms invade the pleura secondarily and can be seen in patients with bronchogenic carcinoma, breast cancer, lymphoma, and ovarian or gastric carcinoma. Primary pleural neoplasms are less common, although they have developed notoriety since the up-surge of malignant mesothelioma and the knowledge of its connection to asbestos exposure. Other malignant primary tumors include localized fibrous tumor and pleural liposarcoma. In most patients with diffuse malignant pleural disease the chest radiograph shows pleural effusion with or without pleural thickening. Computed tomography (CT) usually provides precise localization and extent of the disease and may be of value in assessing chest wall and mediastinal involvement. In specific situations, magnetic resonance (MR) may be useful as a problem-solving tool when CT findings of chest wall or diaphragmatic invasion are equivocal or in patients with contraindication to intravenous administration of ionic contrast material.

Bonomo, Lorenzo E-mail: l.bonomo@radiol.unich.it; Feragalli, Beatrice; Sacco, Rocco; Merlino, Biagio; Storto, Maria Luigia

2000-05-01

144

Diagnostic value of FDG PET-CT for detecting primary breast malignancy: comparison with other image modalities and histopathologic correlation  

International Nuclear Information System (INIS)

To compare the diagnostic value of 18F-FDG PET-CT in detecting the primary breast malignancy with other imaging modalities and to determine whether detectability of PET-CT depends on any factors such as size, differentiation, or nuclear grade of tumor. We evaluated pathologically proven 66 lesions in 61 patients (26-74 years, mean 46.9) who underwent preoperative PET-CT. Other imaging modalities were also evaluated: mammography in 58, US in 49 and MRI in 16. PET-CT images were visually evaluated and peak and mean SUV of mass were measured. For mammography and US, category 4 and 5 lesions as positive, and category 0-3 lesions as negative. For MRI, we used morphology and dynamic kinetic curve data based scoring system; sum of the scores higher than 10 as positive. Sensitivities of each modality were obtained. We analyzed PET-CT positive and negative groups in relation to size, SUV, differentiation and nuclear grade of tumors using paired t-test and Fisher's exact test. 65 among 66 were malignant lesions: invasive ductal carcinoma (n=56), ductal carcinoma in situ (n=3), tubular carcinoma (n=1), medullary carcinoma(n=3), mucinous carcinoma(n=1) and malignant fibrous histiocytoma (n=1). One lesion was benign lesion. Sensitivities of PET-CT, mammography, US, and MRI for detecting malignant mass were 86.2%, 80.7%, 100% and 94.1% respectively. SUV(P) and SUV(M) in PET-CT positive group (5.28±3.24 and 3.56±2.24) was significantly higher than that of PET CT negative group (1.r than that of PET CT negative group (1.96±0.35 and 1.46±0.44) [p<0.0001 for both]. The size of the primary mass in PET-CT positive group (2.66±1.47) was significantly larger than that in PET-CT negative group (1.52±0.57) (p=0.0002). The nuclear grade and tumor differentiation were not significantly different between two groups. The sensitivity of the FDG PET-CT in detecting primary breast cancer is lower than those of other imaging modalities. The detectability of the FDG PET-CT might be degraded when the tumor is small in size

145

Generalized Eruptive Histiocytomas and Rosai-Dorfman Disease Presenting Concurrently in a Patient with Myelodysplastic Syndrome  

Science.gov (United States)

Non-Langerhans cell histiocytoses were originally described as individual diagnoses. However, evidence has been mounting that these entities are manifestations on a spectrum of the same disease. The authors present a patient who initially presented with lymphadenopathy, pancytopenia, splenomegaly, and high-grade fevers. A bone marrow biopsy was performed and she was diagnosed with myelodysplastic syndrome with trisomy 8. Several months later, her persistent pulmonary lymphadenopathy was biopsied revealing Rosai-Dorfman disease. Two years after her initial hospitalization, the patient presented with lesions consistent with generalized eruptive histiocytomas. This case highlights the difficulty that clinicians encounter when trying to separate generalized eruptive histiocytomas, Rosai-Dorfman disease, and the other non-Langerhans cell histiocytoses. While further research needs to be performed in the field of histiocytoses, this case provides clinical support that these diseases are closely linked. PMID:22916314

Darabi, Kamruz; Peters, Sara; Peters, Sara; Kynyk, Jessica; Bechtel, Mark

2012-01-01

146

Permeability of fibrous porous media  

International Nuclear Information System (INIS)

A solution of high-molecular-weight polymer can be viewed at the molecular level as a network of entangled chains. during flow, the network deforms and, to understand the hydrodynamic forces involved, the network can be treated as a porous medium. The physical situation is then the flow of a Newtonian fluid through a fibrous porous medium of low density. The purpose of the present work is to find a relation by both analysis and experiment for a randomly-oriented fibrous porous medium

147

Determinants of outcome of solitary fibrous tumors of the pleura: an observational cohort study  

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BACKGROUND Solitary fibrous tumors of the pleura (SFTP) are rare and their long-term outcome is difficult to predict, as there are insufficient data which allow accurate characterization of the malignant variant. Thus the aim of this study was to describe the outcome and possible determinants of malignant behavior of SFTPs. METHODS Data were collected retrospectively from medical records of patients treated at the University Hospital Zurich from 1992 to 2012. Kaplan-Meier and Cox regressio...

Franzen, Daniel; Diebold, Matthias; Soltermann, Alex; Schneiter, Didier; Kestenholz, Peter; Stahel, Rolf; Weder, Walter; Kohler, Malcolm

2014-01-01

148

Primary malignant liver mesenchymal tumor: A case report  

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Primary malignant liver mesenchymal tumor is a rare condition defined as a tumor with vascular, fibrous, adipose, and other mesenchymal tissue differentiation. We report a case of primary malignant liver mesenchymal tumor in a 51-year-old male with anemia, weight loss and hepatomegaly. Finally unconventional liver biopsy and histological manifestation led to the definitive diagnosis.

Jing Chen, Ya-ju Du

2010-01-01

149

Fibrous metaphyseal defect (fibrous cortical defect, non-ossifying fibroma)  

International Nuclear Information System (INIS)

Fibrous cortical defect and nonossifying fibromas can be classified together as fibrous metaphyseal defects (FMD) since they have the same pahtological substrate, with a tendency to the same localisation around the knee, and occuring at the same age. They have a tendency to spontaneous healing, are clinically silent and are usually discovered accidentally during radiological examination. A radiological survey fo 5.674 metaphyseal regions in the upper and lower extremities of 2.065 unselected patients aged one to 20 years revealed an incidence of 1.8%; exlcusive examination of the distal femur showed an incidence of 2.7%. 96% of all lesions were in the lower extremities and only 4% in the upper. The marked discrepancy in the incidence rate between American and German publications is discussed. (orig.)

150

Monostotic fibrous dysplasia of the ribs.  

Science.gov (United States)

Fibrous dysplasia (FD) is a sporadic benign skeletal disorder that can affect one bone (monostotic form) or multiple bones (polyostotic bone). Around 6-20% of monostotic FD occurs in the ribs. The objective of this study was to report our experience in the management of the monostotic FD of the ribs. Between January 2004 and December 2009, seven cases of FD of the rib (six men and one woman, mean age 30.4 years, range 17-40 years) were operated on. The patients were evaluated with plain radiographs and computer tomography (CT). All our patients were symptomatic; two patients presented chest pain and swelling and other patients presented only chest pain. One rib was involved in all our patients (monostotic form): the site was fifth rib (four cases), sixth rib (two cases) or second rib (one case). Radiologically, plain films and CT showed an expansible lesion with a ground-glass centre and thinning of the cortex. Rib resection was performed in all patients; there were no postoperative complications and no recurrence in all cases at mean 43 month follow-up. In symptomatic monostotic FD of ribs, the involved segment of bone may be excised to rule out malignancy and for painful lesions. PMID:22108945

Traibi, Akram; El Oueriachi, Faycal; El Hammoumi, Massine; Al Bouzidi, Abderahman; Kabiri, El Hassane

2012-01-01

151

Pazopanib Hydrochloride Followed By Chemotherapy and Surgery in Treating Patients With Soft Tissue Sarcoma  

Science.gov (United States)

Adult Angiosarcoma; Adult Desmoplastic Small Round Cell Tumor; Adult Epithelioid Hemangioendothelioma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Dermatofibrosarcoma Protuberans; Stage IIA Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

2014-12-08

152

Fibrous proteins and tissue engineering  

Directory of Open Access Journals (Sweden)

Full Text Available Fibrous proteins are finding broad impact in biomaterial systems for a range of cell and tissue studies. This impact derives from an improved insight into fundamental structure-function relationships, as well as the unique material properties attained with these protein polymers. Recent advances in the use of these protein systems in a variety of biomaterial and tissue engineering applications are reviewed, with a focus on approaches to control the structure, chemistry, and morphology of the biomaterials formed and enable cell and tissue outcomes to be directed in vitro and in vivo.

Xianyan Wang

2006-12-01

153

Modelling fracture in fibrous microstructures  

Energy Technology Data Exchange (ETDEWEB)

This work describes some complementary studies directed towards micromechanical modeling and simulation of the statistical fracture process in composites with fibrous microstructures. A few studies involve combining efficient computational stress analyses and piezospectroscopic measurement techniques to quantify interface deformation around a single break in model composites. It is shown how estimated interface parameters can be used to predict activity around more complex break arrangement in much larger composites. The final studies involve incorporating these experimentally refined stress analyses into large scale simulation for statistical predictions and subsequent analytical modeling of composite fracture.

Beyerlein, I.

1998-04-01

154

Flame resistant fibrous structures development  

Science.gov (United States)

The purpose of the current program was (1) to investigate potentially useful new polymers, both for fire safety and mechanical properties, (2) to produce fibers from these polymers if necessary, and (3) to produce sufficient quantities of qualified fibrous structures, composites, or laminates for use in various areas of the Space Shuttle and Space Station Programs. During the past six years, development efforts have been expended in several major areas in support of Space Shuttle missions and Space Station Freedom projects. The summarized results of several of these major efforts are included in this report.

Coskren, Robert J.

1992-01-01

155

Creep of fibrous composite materials  

DEFF Research Database (Denmark)

Models are presented for the creep behaviour of fibrous composite materials with aligned fibres. The models comprise both cases where the fibres remain rigid in a creeping matrix and cases where the fibres are creeping in a creeping matrix. The treatment allows for several contributions to the creep strength of composites. The advantage of combined analyses of several data sets is emphasized and illustrated for some experimental data. The analyses show that it is possible to derive creep equations for the (in situ) properties of the fibres. The experiments treated include model systems such as Ni + W-fibres, high temperature materials such as Ni + Ni3Al + Cr3C2-fibres, and medium temperature materials such as Al + SiC-fibres. For the first two systems reasonable consistency is found for the models and the experiments, while for the third system too many unquantified parameters exist and further studies seem necessary.

Lilholt, Hans

1985-01-01

156

Infrared emittance of fibrous materials.  

Science.gov (United States)

A theory of the IR emittance of fibrous materials has been developed. The theory predicts the IR spectral emittance of a matte of randomly arrayed cylindrical fibers as a function of the optical constants of the fiber material, the fiber diameter, the packing density of the fibers, the packing of the fibers within fiber bundles, the reflectance of the substrate, and the thickness of the fabric layer. Theoretical simulations were made and compared with experimental measurements of the IR emittance of polypropylene samples. Both the theory and the experimental data confirm the validity of the concept that fabrics can be tailored by a proper choice of the above parameters so as to obtain an emittance distinctly different from unity. PMID:20212721

Aronson, J R; Emslie, A G; Ruccia, F E; Smallman, C R; Smith, E M; Strong, P F

1979-08-01

157

Posttraumatic Reactive Fibrous Bone Neoformation of the Anterior Skull Base Mimicking Osteosarcoma  

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Objectives: Malignant bone tumors and fibro-osseous bone lesions of the skull base are uncommon, although fibrous dysplasia in this anatomic location is not a rare condition. In general, fibro-osseous lesions of the skull are often difficult to classify on either clinical presentation, radiological findings, or histological presentation alone. The objective of this article is to present a probably important differential in the management of bony neoformations of the skull and to highlight the...

Pfeiffer, Jens; Kayser, Gian; Boedeker, Carsten C.; Ridder, Gerd J.

2008-01-01

158

Giant solitary fibrous tumour of the pleura.  

Science.gov (United States)

Solitary fibrous tumour of the pleura is a rare primary pleural neoplasm. These tumours are usually asymptomatic and are incidentally detected. Majority of these neoplasms are benign and surgical excision provides excellent results. With the widespread use of imaging and better diagnostic criteria, this tumour is likely to be detected more frequently. We encountered a patient with a giant solitary fibrous tumour of the pleura. In this report, we describe the case of a patient with a giant solitary fibrous tumour of the pleura, review the literature and present the details of management of this patient. PMID:22779124

Burrah, Rajaram; Veerendra, K V; Deshmane, V; Rao, Rama C; Althaf, S; Pingali, S; Shah, A D; Srinivasalu, Y

2012-01-01

159

Gastric calcifying fibrous tumor removed by endoscopic submucosal dissection  

Directory of Open Access Journals (Sweden)

Full Text Available The World Health Organization describes calcifying fibrous tumors (CFTs as rare, benign lesions characterized by hypocellular, densely hyalinized collagenization with lymphoplasmacytic infiltration. These tumors rarely involve the gastrointestinal (GI tract. A routine endoscopic upper gastrointestinal screen detected a 10-mm submucosal tumor (SMT in the lesser curvature of the lower corpus of the stomach of an apparently healthy, 37-year-old woman with no history of Helicobacter pylori infection. Endoscopic ultrasonography (EUS localized the internally isoechoic, homogeneous SMT mainly within the submucosa. Malignancy was ruled out using endoscopic submucosal dissection (ESD. A pathological examination confirmed complete resection of the SMT, and defined a hypocellular, spindle-cell tumor with a densely hyalinized, collagenous matrix, scattered lymphoplasmacytic aggregates as well as a few psammomatous, dystrophic calcified foci. The mass was immunohistochemically positive for vimentin and negative for CD117 (c-kit protein, CD34, desmin, smooth muscle actin (SMA and S100. Therefore, the histological findings were characteristic of a CFT. To date, CFT resection by ESD has not been described. This is the first case report of a gastric calcifying fibrous tumor being completely resected by ESD after endoscopic ultrasonography.

Naotaka Ogasawara

2013-01-01

160

Malignant mesothelioma  

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Abstract Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium) of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis. The exact prevalence is unknown but it is estimated that mesotheliomas represent less than 1% of all cancers. Its incidence is increasing, with an expected peak in the next 10–20 years. Pleural malignant mesothelioma is the most common form of mesothelioma. Typical pres...

Parker Robert J; Moore Alastair J; Wiggins John

2001-01-01

 
 
 
 
161

Tissue Engineering with Nano-Fibrous Scaffolds  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Tissue Engineering is a rapidly evolving field in terms of cell source and scaffold fabrication. As the template for three dimensional tissue growth, the scaffold should emulate the native extracellular matrix, which is nano-fibrous. Currently, there are three basic techniques capable of generating nano-fibrous scaffolding: electrospinning, molecular self-assembly, and thermally induced phase separation. These scaffolds can then be further modified by various three dimensional surface modific...

Smith, Laura A.; Liu, Xiaohua; Ma, Peter X.

2008-01-01

162

Sampling Citrus Fibrous Roots and Tylenchulus semipenetrans  

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Sampling precision was investigated for Tylenchulus semipenetrans juveniles and males in soil and females from roots and for citrus fibrous root mass density. For the case of two composite samples of 15 cores each, counts of juvenile and male nematodes were estimated to be within 40% of ?, at P 1,500 nematodes/100 cm³ soil. A similar level of ? was estimated for measurements of fibrous root mass density, but at a precision level of 25% of ?. Densities o...

Duncan, L. W.; El-morshedy, M. M.; Mcsorley, R.

1994-01-01

163

Primary solitary fibrous tumor of the retroperitoneum  

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Solitary fibrous tumor is an uncommon neoplasm affecting adults and typically located in the pleura and can also occur in a large number of other extra thoracic sites. We present the case of a solitary fibrous tumor (SFT) of the retroperitoneum and describe their histopathological and immunohistochemical features. The identification of SFT in the retroperitoneum is of importance because its clinico-pathological behaviour is still unclear. The pathologist plays a fundamental role in establishi...

Najat Mahassini; Ahmed Jahid; Khalid Lahlou; Rachid Elktaibi; Abderrahim Elktaibi; Fatima Mansouri; Azzouz Haddan; Siham Mesmoudi; Zakiya Bernoussi; Hind Charhi

2011-01-01

164

Primary solitary fibrous tumor of the retroperitoneum.  

Science.gov (United States)

Solitary fibrous tumor is an uncommon neoplasm affecting adults and typically located in the pleura and can also occur in a large number of other extra thoracic sites. We present the case of a solitary fibrous tumor (SFT) of the retroperitoneum and describe their histopathological and immunohistochemical features. The identification of SFT in the retroperitoneum is of importance because its clinico-pathological behaviour is still unclear. The pathologist plays a fundamental role in establishing both the positive and differential diagnosis. PMID:24765378

Charhi, Hind; Bernoussi, Zakiya; Haddan, Azzouz; Mesmoudi, Siham; Elktaibi, Abderrahim; Mansouri, Fatima; Elktaibi, Rachid; Lahlou, Khalid; Jahid, Ahmed; Mahassini, Najat

2011-09-28

165

[Polyostotic fibrous dysplasia. A clinical case report  

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The authors present a severe case of polyostotic fibrous dysplasia in which there was considerable involvement of cranial bone and facial skeleton. Numerous lesions were present at the level of the long bones of limbs. Endocrine dysfunction was also present in the form of a hypophyseal adenoma secreting prolactin and ACTH. The concomitance of acromegaly or gigantism and/or hyperprolactinemia and polyostotic fibrous dysplasia has only been reported to date in a few cases in literature. The aut...

Gallesio, Cesare

1996-01-01

166

Solitary Fibrous Tumor of the Larynx  

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Background True mesenchymal, non-cartilaginous neoplasms of the larynx are rare. Extrapleural solitary fibrous tumor (SFT) is a localized neoplasm characterized by proliferation of thin-walled vessels and collagen-producing cells and is considered within the “hemangiopericytoma-solitary fibrous tumor” spectrum. SFT primary in the larynx is exceptional. Design Case report set in a comparison with other cases reported in the English literature (MEDLINE 1966 to 2007). Results A 49-year old w...

Thompson, Lester D. R.; Karamurzin, Yevgeniy; Wu, Mark Li-cheng; Kim, Jason H.

2008-01-01

167

From the archives of the AFIP: benign fibrous tumors and tumorlike lesions of the mesentery: radiologic-pathologic correlation.  

Science.gov (United States)

Mesenteric fibromatosis, sclerosing mesenteritis, inflammatory pseudotumor, and extrapleural solitary fibrous tumor constitute a loosely associated group of benign fibrous tumors and tumorlike lesions of the mesentery. These lesions are linked histologically by the presence of fibroblasts or fibrosis and anatomically by their location within the mesentery. Although rare, and distinctly different in pathogenesis and biologic behavior, these fibrous lesions have pathologic and radiologic features that overlap with one another and with more common neoplastic and nonneoplastic lesions of the mesentery. Mesenteric fibromatosis is a locally aggressive, benign proliferative process that may occur sporadically or in association with familial adenomatous polyposis. It most frequently manifests as a focal mesenteric mass and may simulate lymphoma, metastatic disease, or a soft-tissue sarcoma. Sclerosing mesenteritis is a rare idiopathic disorder that most commonly produces a stellate mass within the mesentery and should be differentiated from metastatic disease, specifically metastatic carcinoid, because it frequently responds to conservative or medical management. Inflammatory pseudotumor (inflammatory myofibroblastic tumor) is a benign, chronic inflammatory disorder of unknown cause that manifests as a solid mesenteric mass, indistinguishable from malignancy. Extrapleural solitary fibrous tumor is a tumor of submesothelial origin that is identical to the solitary fibrous tumor of the pleura. When located in the mesentery or peritoneal cavity, extrapleural solitary fibrous tumor has an imaging pattern that must be differentiated from metastatic disease, soft-tissue sarcomas, and other benign and malignant neoplasms of the mesentery and peritoneum. Knowledge of this group of benign fibrous tumors and tumorlike lesions of the mesentery is important in the preoperative evaluation of a mesenteric mass. PMID:16418255

Levy, Angela D; Rimola, Jordi; Mehrotra, Anupamjit K; Sobin, Leslie H

2006-01-01

168

Secondary aneurysmal bone cyst in fibrous dysplasia of the proximal femur.  

Science.gov (United States)

Fibrous dysplasia of bone is a congenital skeletal disorder characterized by proliferation of spindle cells inside an intramedullary collagenous stroma and by formation of metaplastic bone. An aneurysmal bone cyst is a lesion of unknown etiology. Macroscopically it appears like a blood-filled cavity that expands the affected bone. Histologically, fibrous septa are bordered by macrophages, giant cells, inflammatory cells, and areas of bone production. Hemorrhagic areas can rise into fibrous dysplasia. The lesion appears as an aggressive and destructive process that is difficult to diagnose properly. A 29-year-old woman presented with a 2-year history of left inguinal and lumbar pain. She reported increased pain after physical activity. Magnetic resonance imaging of the left femur (without intravenous gadolinium) showed a mass extending 14 cm along the femoral metaphysis. This lesion involved cortical bone that was broken in the posteromedial site. Computed tomography confirmed the osteostructural lytic alteration that "blows up" the proximal femur metaphysis. A trochar biopsy allowed the diagnosis of aneurysmal bone cyst on fibrous dysplasia, excluding malignancy. The lesion was treated with curettage and local adjuvants and filled with bone grafts. Internal fixation with a sliding screw plate was also performed. Radiographs at 1 year postoperatively showed good consolidation of the grafts and absence of local recurrence. The patient achieved active and passive mobilization of the left hip with no pain. PMID:19472953

Montalti, Maurizio; Alberghini, Marco; Ruggieri, Pietro

2009-05-01

169

Fibrous tissue and angiotensin II.  

Science.gov (United States)

Myofibroblasts (myoFb) are cells responsible for fibrous tissue formation in injured systemic organs such as the heart. Cultured myoFb, obtained from rat cardiac scar tissue, express genes that encode components requisite for angiotensin (Ang) II generation, which in turn regulates myoFb collagen turnover in an autocrine/paracrine manner. In this study, we tested the hypothesis that these wound-healing fibroblast-like cells and locally generated Ang II are involved in other repairing tissue. To test this hypothesis, we used a granuloma pouch model, where a subcutaneous air sac is created followed by injection of croton oil. Pouch tissue was collected at days 4, 7, 14 and 21. The presence of myoFb was determined by immunohistochemical alpha-smooth muscle actin (alpha-SMA) labeling and collagen accumulation by picrosirius red staining. Angiotensin converting enzyme (ACE) and Ang II receptor binding were detected by in vitro quantitative autoradiography using 125I-351A and 125I[Sar1, Ile8]Ang II, respectively, while Ang II receptor subtype was defined by displacement studies using either an AT1 (losartan) or AT2 (PD123177) receptor antagonist. Cells expressing ACE were determined by immunohistochemistry. Ang II content in pouch tissue was measured by radioimmunoassay following HPLC separation while its capacity to generate Ang II was assessed in tissue bath, with and without exogenous Ang I or lisinopril, an ACE inhibitor. Collagen accumulation in pouch tissue was examined by determining hydroxyproline content in response to lisinopril, AT1 or AT2 receptor antagonists (losartan or PD123177). In pouch tissue, we found: (1) myoFb at day 4 which became more extensive at days 7, 14 and 21; (2) morphologic evidence of collagen deposition evident at day 4, which gradually became more extensive thereafter; (3) ACE and Ang II receptor binding was evident at day 4 and remained invariant on days 7, 14 and 21; (4) the predominant Ang II receptor subtype expressed was AT1; (5) myoFb express ACE and AT1 receptors; (6) picogram quantities of Ang II (per g tissue) was evident on days 7, 14 and 21; and (7) Ang II was generated from Ang I substrate. Lisinopril and losartan, but not PD123177, significantly attenuated pouch weight and accumulation of collagen. Thus, in this model of cutaneous repair, the appearance of myoFb is associated with Ang II generation that regulates fibrogenesis by AT1 receptor binding. Signals involved in the appearance of myoFb remain uncertain. Further studies are required to address the regulation of Ang II generation in pouch tissue of the rat. PMID:9281434

Sun, Y; Ramires, F J; Zhou, G; Ganjam, V K; Weber, K T

1997-08-01

170

Congenital fibrous hamartoma of the knee  

International Nuclear Information System (INIS)

A full-term male infant presented at birth with a hard swelling of the left knee. The lemon-sized lesion was fixed to the underlying knee muscles, while the overlying skin was stretched and shiny; there was no bruit. Radiography, sonography and MRI suggested a soft-tissue tumour. After surgical excision, histology showed the presence of fibrous and mesenchymal tissue, with mature adipose tissue. Fibrous hamartoma of infancy was diagnosed. Among soft-tissue tumours, fibrous hamartoma of infancy is a rare and benign lesion, occurring in the first 2 years of life. The tumour mainly affects the trunk, axilla, and upper extremities. This infant had unique involvement of the knee. The treatment of choice is local excision. (orig.)

171

Congenital fibrous hamartoma of the knee  

Energy Technology Data Exchange (ETDEWEB)

A full-term male infant presented at birth with a hard swelling of the left knee. The lemon-sized lesion was fixed to the underlying knee muscles, while the overlying skin was stretched and shiny; there was no bruit. Radiography, sonography and MRI suggested a soft-tissue tumour. After surgical excision, histology showed the presence of fibrous and mesenchymal tissue, with mature adipose tissue. Fibrous hamartoma of infancy was diagnosed. Among soft-tissue tumours, fibrous hamartoma of infancy is a rare and benign lesion, occurring in the first 2 years of life. The tumour mainly affects the trunk, axilla, and upper extremities. This infant had unique involvement of the knee. The treatment of choice is local excision. (orig.)

Arioni, Cesare; Bellini, Carlo; Risso, Francesco Maria; Scopesi, Fabio; Serra, Giovanni [University of Genoa, Neonatal Pathology Service, Department of Paediatrics, Institute G. Gaslini, Genoa (Italy); Oddone, Mauro; Toma, Paolo [Institute G. Gaslini, Radiology Service, Genoa (Italy); Nozza, Paolo [Institute G. Gaslini, U. O. di Anatomia Patologica, Genoa (Italy)

2006-05-15

172

Enzymes in bast fibrous plant processing.  

Science.gov (United States)

The program COST Action 847 Textile Quality and Biotechnology (2000-2005) has given an excellent chance to review the possibilities of the research, aiming at development of the industrial application of enzymes for bast fibrous plant degumming and primary processing. The recent advancements in enzymatic processing of bast fibrous plants (flax, hemp, jute, ramie and alike plants) and related textiles are given. The performance of enzymes in degumming, modification of bast fibres, roving, yarn, related fabrics as well as enzymatic bonding of lignocellulosic composites is provided. PMID:16791732

Kozlowski, Ryszard; Batog, Jolanta; Konczewicz, Wanda; Mackiewicz-Talarczyk, Maria; Muzyczek, Malgorzata; Sedelnik, Natalia; Tanska, Bogumila

2006-05-01

173

On the filtration of fibrous aerosols  

International Nuclear Information System (INIS)

Basic peculiarities occuring during the filtration of fibrous aerosols are discussed. Using aerosols of very fine asbestos fibers, filtration efficiencies of some analytical filters -Nuclepore and Millipore filters - were investigated. The collection efficiences were measured by means of electron microscopy and radiolabeled asbestos fibers. The collection efficiencies, which depended on the pore sizes of the filters and on the fiber form of the used aerosol, lay in the range of about 40-99.9%. A special problem discussed is the orientation of fibrous particles in the vicinity of filter pore entrances. (author)

174

Primary solitary fibrous tumor of the retroperitoneum  

Directory of Open Access Journals (Sweden)

Full Text Available Solitary fibrous tumor is an uncommon neoplasm affecting adults and typically located in the pleura and can also occur in a large number of other extra thoracic sites. We present the case of a solitary fibrous tumor (SFT of the retroperitoneum and describe their histopathological and immunohistochemical features. The identification of SFT in the retroperitoneum is of importance because its clinico-pathological behaviour is still unclear. The pathologist plays a fundamental role in establishing both the positive and differential diagnosis.

Najat Mahassini

2011-09-01

175

Extraction of uranium from seawater by the fibrous composite adsorbent  

International Nuclear Information System (INIS)

The fibrous composite adsorbents consisting of hydrous titanium oxide and activated carbon were prepared with hydrophilic polyacrylonitrile system polymer as a binder under various conditions, and the adsorptive property of the fibrous composite adsorbents for uranium from seawater was examined. The fibrous composite adsorbents which spun under high pressure (10 kg/cm2) was the finest having the largest pore volume. In addition, the amount of uranium adsorbed of the fibrous adsorbent was the largest. The rate of uranium adsorption by the fibrous adsorbent was the same as the rate of uranium adsorption by the powdery adsorbent. The excellent fibrous adsorbent adsorbed 0.23 mg U/g adsorbent for 10 d and 0.65 mg U/g adsorbent for 100 d. The rate of uranium desorption from the fibrous adsorbent by alkali carbonate solution was large, and the uranium in the fibrous adsorbent desorbed 75 % for 8 h and about 100 % for 24 h. (author)

176

Malignant meningioma  

International Nuclear Information System (INIS)

The intracranial meningiomas are tumors in general of benign type of a slow growth originating in the arachnoid cells layer, especially in arachnoid granulations. The anaplastic or malignant meningiomas accounted for only the 1-3%. Sometimes they simulate malignant neuroepithelial lesions due to its fast growth and the frequent invasion of surrounding cerebral tissue with very frequent relapses and many times they required adjuvant therapy. The topographic images of this type of tumor are hyper-denses with a good contrast capture, regular and well defined with not much or not associated edema, quite the contrary that observed in present case where images seems to correspond with those of a malignant glioma (multiforme glioblastoma). (author)

177

FIBROUS DYSPLASIA IN THE MAXILLO-MANDIBULAR REGION – case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Craniofacial fibrous dysplasia is 1 of 3 types of fibrous dysplasia that can affect the bones of the craniofacial complex, including the mandible and maxilla.Fibrous displasia is a skeletal developmental disorder of the bone-forming mesenchyme that manifests as a defect in osteoblastic differentiation and maturation. It is a lesion of unknown etiology, uncertain pathogenesis, and diverse histopathology. Fibrous dysplasia represents about 2, 5% of all bone tumors and over 7% of all benign tumo...

Radka Cholakova; Kanasirska, P.; Kanasirski, N.; Ivan Chenchev; Atanaska Dinkova

2010-01-01

178

Malignant mesothelioma  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis. The exact prevalence is unknown but it is estimated that mesotheliomas represent less than 1% of all cancers. Its incidence is increasing, with an expected peak in the next 10–20 years. Pleural malignant mesothelioma is the most common form of mesothelioma. Typical presenting features are those of chest pain and dyspnoea. Breathlessness due to a pleural effusion without chest pain is reported in about 30% of patients. A chest wall mass, weight loss, sweating, abdominal pain and ascites (due to peritoneal involvement are less common presentations. Mesothelioma is directly attributable to occupational asbestos exposure with a history of exposure in over 90% of cases. There is also evidence that mesothelioma may result from both para-occupational exposure and non-occupational "environmental" exposure. Idiopathic or spontaneous mesothelioma can also occur in the absence of any exposure to asbestos, with a spontaneous rate in humans of around one per million. A combination of accurate exposure history, along with examination radiology and pathology are essential to make the diagnosis. Distinguishing malignant from benign pleural disease can be challenging. The most helpful CT findings suggesting malignant pleural disease are 1 a circumferential pleural rind, 2 nodular pleural thickening, 3 pleural thickening of > 1 cm and 4 mediastinal pleural involvement. Involvement of a multidisciplinary team is recommended to ensure prompt and appropriate management, using a framework of radiotherapy, chemotherapy, surgery and symptom palliation with end of life care. Compensation issues must also be considered. Life expectancy in malignant mesothelioma is poor, with a median survival of about one year following diagnosis.

Parker Robert J

2008-12-01

179

Malignant Catatonia  

Directory of Open Access Journals (Sweden)

Full Text Available Catatonia is a syndrome characterized by mutism, immobility, negativism, stereotypy, mannerisms, echophenomena, perseveration and passive obedience. The underlying causes can be psychiatric or may be associated with general medical status or neurological diseases. Additionally catatonia has two subtypes as malignant and nonmalignant catatonia. Main symptoms of malignant catatonia are hyperthermia and autonomic symptoms such as tachycardia, tachypnea and hyperhidrosis. It is important to make the diagnosis as early as possible for an appropriate medical treatment. Clinicians should be aware of the fatal outcome of the disease.

Ayca Ozkul

2010-12-01

180

Unilateral Fibrous ankylosis of the Temporomandibular Joint  

Directory of Open Access Journals (Sweden)

Full Text Available Ankylosis of the Temporomandibular joint (TMJ is a chronic mandibular hypomobility and is one of the commonest TMJ disorders encountered in the patients.The present case is about the history of fourteen years old fibrous ankylosis of the condyle of the TMJ with its clinical and the radiological features and the treatment modalities.

Kamala R

2012-04-01

 
 
 
 
181

Unilateral Fibrous ankylosis of the Temporomandibular Joint  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Ankylosis of the Temporomandibular joint (TMJ) is a chronic mandibular hypomobility and is one of the commonest TMJ disorders encountered in the patients.The present case is about the history of fourteen years old fibrous ankylosis of the condyle of the TMJ with its clinical and the radiological features and the treatment modalities.

Kamala R; Jayanthi K; Gaurav; Shivu

2012-01-01

182

Development of oxide fibrous monolith systems.  

Energy Technology Data Exchange (ETDEWEB)

Fibrous monolithic ceramics generally have a cellular structure that consists of a strong cell surrounded by a weaker boundary phase [1-5]. Fibrous monoliths (FMs) are produced from powders by conventional ceramic fabrication techniques, such as extrusion [1,2]. When properly engineered, they exhibit fail gracefully [3-5]. Several compositions of ceramics and cermets have been processed successfully in fibrous monolithic form [4]. The most thoroughly investigated fibrous monolith consists of Si{sub 3}N{sub 4} cells and a BN cell-boundary phase [3-5]. Through appropriate selection of initial powders and extrusion and hot-pressing parameters, very tough final products have been produced. The resultant high toughness is due primarily to delamination during fracture along textured platelike BN grains. The primary objectives of our program are to develop: (1) Oxide-based FMs, including new systems with improved properties; (2) FMs that can be pressureless sintered rather than hot-pressed; (3) Techniques for continuous extrusion of FM filaments, including solid freeform fabrication (SFF) for net-shape fabrication of FMs; (4) Predictive micromechanical models for FM design and performance; and (5) Ties with industrial producers and users of FMs.

Goretta, K. C.

1999-03-02

183

History Of Impregnation Techniques With Fibrous Materials  

International Nuclear Information System (INIS)

The importance of wood as a raw material is described and its deficiencies are listed. The history of the development of some impregnatio processes for fibrous materials is outlined and a hopeful prognosis for the future utilization of improved wood is made. (author)

184

Steam Reformer With Fibrous Catalytic Combustor  

Science.gov (United States)

Proposed steam-reforming reactor derives heat from internal combustion on fibrous catalyst. Supplies of fuel and air to combustor controlled to meet demand for heat for steam-reforming reaction. Enables use of less expensive reactor-tube material by limiting temperature to value safe for material yet not so low as to reduce reactor efficiency.

Voecks, Gerald E.

1987-01-01

185

Malignant Pyoderma  

Directory of Open Access Journals (Sweden)

Full Text Available A 30 year old man presented with multiple ulcers with necrotic base over scalp, neck, presternal region. Neither any systemic disease was associated nor any abnormality by laboratory investigation was found. Patient responding well to dapsone and corticosteroid. It was designated as a case of malignant pyoderma.

Mohanty Juthika

2002-01-01

186

Hematologic malignancies  

Energy Technology Data Exchange (ETDEWEB)

The principle aim of this book is to give practical guidelines to the modern treatment of the six important hematologic malignancies. Topics considered include the treatment of the chronic leukemias; acute leukemia in adults; the myeloproliferative disorders: polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis/agnogenic myeloid metaplasia; Hodgkin's Disease; non-Hodgkin's lymphoma; and Multiple Myeloma.

Hoogstraten, B.

1986-01-01

187

Hematologic malignancies  

International Nuclear Information System (INIS)

The principle aim of this book is to give practical guidelines to the modern treatment of the six important hematologic malignancies. Topics considered include the treatment of the chronic leukemias; acute leukemia in adults; the myeloproliferative disorders: polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis/agnogenic myeloid metaplasia; Hodgkin's Disease; non-Hodgkin's lymphoma; and Multiple Myeloma

188

Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia  

International Nuclear Information System (INIS)

We describe two cases of elderly women who presented hypoglycemic episodes with suppressed levels of insulin and insulin-like growth factor I. They were found to have huge malignant solitary fibrous tumor of the pleura. The tumors had rich vascularization on enhanced CT scans and showed characteristic low signal intensity on T2-weighted MR images. This paraneoplastic hypoglycemia is caused by an incompletely processed precursor of insulin-like growth factor II secreted from the tumor. Hypoglycemia and insulin suppression were resolved after removal of the tumors. (orig.)

189

Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia  

Energy Technology Data Exchange (ETDEWEB)

We describe two cases of elderly women who presented hypoglycemic episodes with suppressed levels of insulin and insulin-like growth factor I. They were found to have huge malignant solitary fibrous tumor of the pleura. The tumors had rich vascularization on enhanced CT scans and showed characteristic low signal intensity on T2-weighted MR images. This paraneoplastic hypoglycemia is caused by an incompletely processed precursor of insulin-like growth factor II secreted from the tumor. Hypoglycemia and insulin suppression were resolved after removal of the tumors. (orig.)

Kim, J.H. [Dept. of Diagnostic Radiology, Chungnam National University Hospital, Taejon (Korea); Kim, J.O.; Kim, S.Y. [Dept. of Internal Medicine, Chungnam National University Hospital, Taejon (Korea); Na, M.H.; Lim, S.P. [Dept. of Thoracic Surgery, Chungnam National University Hospital, Taejon (Korea); Kim, J.M. [Dept. of Pathology, Chungnam National University Hospital, Taejon (Korea)

2001-05-01

190

Nonlinear mechanics of soft fibrous materials  

CERN Document Server

The book presents a state-of-the-art overview of the fundamental theories, established models and ongoing research related to the modeling of these materials. Two approaches are conventionally used to develop constitutive relations for highly deformable fibrous materials. According to the phenomenological approach, a strain energy density function can be defined in terms of strain invariants. The other approach is based on kinetic theories, which treats a fibrous material as a randomly oriented inter-tangled network of long molecular chains bridged by permanent and temporary junctions. At the micro-level, these are associated with chemical crosslinks and active entanglements, respectively. The papers include carefully crafted overviews of the fundamental formulation of the three-dimensional theory from several points of view, and address their equivalences and differences. Also included are solutions to boundary-value problems which are amenable to experimental verification. A further aspect is the elasticity...

Ogden, Raymond

2015-01-01

191

Spontaneous fibrous histiocytic neoplasms in rats.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A total of 85 spontaneous rat fibrohistiocytic tumours were evaluated histologically and assessed for the presence or absence of metastases. The overall incidence in controls from 2-year carcinogenicity studies was 2.7%. The tumours occurred principally in the subcutaneous and deep soft tissues, and generally appeared after 18 months of age. Four histological types were recognized: histiocytic (17%), pleomorphic (33%), cellular (17%) and very fibrous (33%). Histiocytic tumours were highly mal...

Greaves, P.; Faccini, J. M.

1981-01-01

192

First description of Phanerozoic radiaxial fibrous dolomite  

Science.gov (United States)

The petrographic analysis and crystallographic analysis of concretionary carbonate cements ("coal balls") from Carboniferous paralic swamp deposits reveal the presence of (length fast) radiaxial fibrous dolomite (RFD), a fabric not previously reported from the Phanerozoic. This finding is of significance as earlier reports of Phanerozoic radiaxial fibrous carbonates are exclusively of calcite mineralogy. Dolomite concretions described here formed beneath marine transgressive intervals within palustrine coal seams. This is of significance as seawater was arguably the main source of Mg2 + ions for dolomite formation. Here, data from optical microscopy, cathodoluminescence, electron backscattered diffraction, X-ray diffraction and geochemical analyses are presented to characterize three paragenetic dolomite phases and one calcite phase in these concretions. The main focus is on the earliest diagenetic, non-stoichiometric (degree of order: 0.41-0.46) phase I, characterized by botryoidal dolomite constructed of fibres up to 110 ?m wide with a systematic undulatory extinction and converging crystal axes. Petrographic and crystallographic evidence clearly qualifies phase I dolomite as radiaxial fibrous. Conversely, fascicular optical fabrics were not found. Carbon-isotope ratios (?13C) are depleted (between - 11.8 and - 22.1‰) as expected for carbonate precipitation from marine pore-fluids in organic-matter-rich, paralic sediment. Oxygen isotope (?18O) ratios range between - 1.3 and - 6.0‰. The earliest diagenetic nature of these cements is documented by the presence of ubiquitous, non-compacted fossil plant remains encased in phase I dolomite as well as by the complex zoned luminescence patterns in the crystals and is supported by crystallographic and thermodynamic considerations. It is argued that organic matter, and specifically carboxyl groups, reduced thermodynamic barriers for dolomite formation and facilitated Mg/CaCO3 precipitation. The data shown here reveal a hitherto unknown level of complexity with respect to radiaxial fibrous carbonates and are of importance for those concerned with dolomite and carbonate petrography in general.

Richter, D. K.; Heinrich, F.; Geske, A.; Neuser, R. D.; Gies, H.; Immenhauser, A.

2014-05-01

193

Toxicity and Carcinogenicity Mechanisms of Fibrous Antigorite  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We studied the effects of fibrous antigorite on mesothelial MeT-5A and monocyte-macrophage J774 cell lines to further understand cellular mechanisms induced by asbestos fibers leading to lung damage and cancer. Antigorite is a mineral with asbestiform properties, which tends to associate with chrysotile or tremolite, and frequently occurs as the predominant mineral in the veins of several serpentinite rocks found abundantly in the Western Alps. Particles containing antigorite are more abundan...

Michael Balazy; Silvana Capella; Annamaria Panico; Elena Belluso; Laura Lombardo; Venera Cardile

2007-01-01

194

A case of fibrous dysplasia showing strong accumulation picture by bone and tumor scintigraphy  

International Nuclear Information System (INIS)

A 47-year-old male patient was hospitalized to receive the operation for a tumor of the left thigh. No accumulation was observed at the tumor on 67Ga-citrate scintigraphy performed preoperatively in order to investigate the malignancy of the tumor, while abnormal accumulation was observed at the left femur and both tibias. Even sup(99m)Tc-MDP bone scintigraphy revealed abnormal accumulation at the both femurs and the both tibias. On CT scanning, the above-mentioned portions showed the pictures of higher density which might be seen to be calcification or ossification. Although we could not perform the biopsy because the patient did not agree with us, in view of histological findings on the biopsy of the left femur performed about 20 years ago, the present case was diagnosed as polyostotic fibrous dysplasia. Though sup(99m)Tc-MDP bone scintigraphic findings of fibrous dysplasia have been reported, we reported this case, thinking that reports on 67Ga-citrate scintigraphy and CT scanning as to fibrous dysplasia were still lacking. (author)

195

Fibrous Hamartoma of Infancy, Report of Two Cases  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: Fibrous hamartoma of infancy (FHI is a rare, benign soft tissue tumor that typically occurs within the first two years of life. It has a specific histologic appearance comprising of three different mesenchymal tissues with variable proportions in an organoid fashion. The clinical course is typically benign with excellent prognosis. We report two cases of this rare lesion and review its cilinicopathologic characteristics. Case(s Presentation: The first case was a 15-month-old girl who had a subcutaneous mass in the right axillary region and the other one was an 18-month-old boy with a mass on the medial surface of his right ankle. The masses were successfully excised. After 6 and 30 months follow up no recurrence occurred. Conclusion: Although the clinical and imaging findings of FHI are quite similar to those of malignant soft tissue tumor, histologic characteristics of this tumor will guide to the definite diagnosis that will prevent aggressive and mutilating procedures.

Ahmad Bazrafshan

2008-05-01

196

A Case of Extensive polyostotic fibrous dysplasia  

Energy Technology Data Exchange (ETDEWEB)

Fibrous dysplasia is a benign disorder of bone consisting of intramedullary proliferation of fibrous tissue and irregularly distributed, poorly developed bone. The disease manifests itself in the monostotic form in which only one bone is involved and the polyostotic form in which multiple bones at different sites are affected. We reported a extensive case of polyostotic fibrous dysplasia with involvement of craniofacial bones, mandible, ribs, extremities. A 18-year-old man showed remarkable right facial swelling who had been treated on right femur 3 years ago with a bone graft for pathologic fracture and he recognized facial swelling 5 years ago. Extraoral radiograms and computed tomogram showed diffuse sclerosis with a ground glass appearance of the most calvarial bones, facial bones. The right mandibular lesion showed very expansible lesion with mottled appearance. Bone scans showed multifocal increased uptakes in craniofacial bones, right mandible, bilaterally in ribs, humerus, femur, tibia and characteristic various deformity of right femur (shepherd's crook deformity). This case showed exceptionally bilateral, extensive nature of bone lesion and didn't show any features of skin pigmentation and endocrine disturbances.

Lee, Byung Do [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Hwang, Eui Hwan; Lee, Sang Rae [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Kyunghee University, Seoul (Korea, Republic of)

2000-06-15

197

Toxicity and carcinogenicity mechanisms of fibrous antigorite.  

Science.gov (United States)

We studied the effects of fibrous antigorite on mesothelial MeT-5A and monocyte-macrophage J774 cell lines to further understand cellular mechanisms induced by asbestos fibers leading to lung damage and cancer. Antigorite is a mineral with asbestiform properties, which tends to associate with chrysotile or tremolite, and frequently occurs as the predominant mineral in the veins of several serpentinite rocks found abundantly in the Western Alps. Particles containing antigorite are more abundant in the breathing air of this region than those typically found in urban ambient air. Exposure of MeT-5A and J774 cells to fibrous antigorite at concentrations of 5-100 microg/ml for 72 hr induced dose-dependent cytotoxicity. Antigorite also stimulated the ROS production, induced the generation of nitrite and PGE2. MeT-5A cells were more sensitive to antigorite than J774 cells. The results of this study revealed that the fibrous antigorite stimulates cyclooxygenase and formation of hydroxyl and nitric oxide radicals. These changes represent early cellular responses to antigorite fibers, which lead to a host of pathological and neoplastic conditions because free radicals and PGE2 play important roles as mediators of tumor pathogenesis. Understanding the mechanisms of the cellular responses to antigorite and other asbestos particles should be helpful in designing rational prevention and treatment approaches. PMID:17431308

Cardile, Venera; Lombardo, Laura; Belluso, Elena; Panico, Annamaria; Capella, Silvana; Balazy, Michael

2007-03-01

198

Toxicity and Carcinogenicity Mechanisms of Fibrous Antigorite  

Directory of Open Access Journals (Sweden)

Full Text Available We studied the effects of fibrous antigorite on mesothelial MeT-5A and monocyte-macrophage J774 cell lines to further understand cellular mechanisms induced by asbestos fibers leading to lung damage and cancer. Antigorite is a mineral with asbestiform properties, which tends to associate with chrysotile or tremolite, and frequently occurs as the predominant mineral in the veins of several serpentinite rocks found abundantly in the Western Alps. Particles containing antigorite are more abundant in the breathing air of this region than those typically found in urban ambient air. Exposure of MeT-5A and J774 cells to fibrous antigorite at concentrations of 5-100 μg/ml for 72 hr induced dose-dependent cytotoxicity. Antigorite also stimulated the ROS production, induced the generation of nitrite and PGE2. MeT-5A cells were more sensitive to antigorite than J774 cells. The results of this study revealed that the fibrous antigorite stimulates cyclooxygenase and formation of hydroxyl and nitric oxide radicals. These changes represent early cellular responses to antigorite fibers, which lead to a host of pathological and neoplastic conditions because free radicals and PGE2 play important roles as mediators of tumor pathogenesis. Understanding the mechanisms of the cellular responses to antigorite and other asbestos particles should be helpful in designing rational prevention and treatment approaches.

Michael Balazy

2007-03-01

199

An unusual pleomorphic sarcoma in a hybrid mallard  

Science.gov (United States)

An unusual pleomorphic sarcoma from a hybrid mallard (Anas platyrhynchos) is described. Rhabdomyosarcoma was considered in the original differential diagnoses but rejected due to lack of specific characteristics generally seen in these tumors. The histologic characteristics described are consistent with mammalian sarcomas recorded in the literature as malignant fibrous histiocytoma.

Roffe, T.J.

1987-01-01

200

Sorafenib in Treating Patients With Metastatic, Locally Advanced, or Recurrent Sarcoma  

Science.gov (United States)

Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Leiomyosarcoma; Adult Malignant Fibrous Histiocytoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Ovarian Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Uterine Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage III Uterine Sarcoma; Stage IV Adult Soft Tissue Sarcoma; Stage IV Uterine Sarcoma; Uterine Carcinosarcoma; Uterine Leiomyosarcoma

2014-05-07

 
 
 
 
201

AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma  

Science.gov (United States)

Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Rhabdomyosarcoma; Dermatofibrosarcoma Protuberans; Endometrial Stromal Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Uterine Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage III Uterine Sarcoma; Stage IV Adult Soft Tissue Sarcoma; Stage IV Uterine Sarcoma; Uterine Carcinosarcoma; Uterine Leiomyosarcoma

2013-05-07

202

Mesenchymal tumors of the liver. Diagnostic problems for the surgical pathologist.  

Science.gov (United States)

Although some mesenchymal lesions include readily diagnosable entities, some patients have difficult presentations and unusual radiographic results. This review of mesenchymal tumors covers hemangioma, infantile hemangioendothelioma, angiomyolipoma, angiosarcoma, epitheloid hemangioendothelioma, fibroma, malignant fibrous histiocytoma, inflammatory pseudotumor, mesenchymal hamartoma, embryonal sarcoma, and sarcomatoid hepatocellular carcinoma. PMID:9420896

Craig, J R

1994-01-01

203

Combination of laser treatment and intraluminal radiotherapy for malignant dysphagia  

International Nuclear Information System (INIS)

Laser treatment for malignant dysphagia is limited by recurrent intraluminal turmour requiring repeated treatment at four to eight week intervals. To reduce the need for follow up treatment and to improve survival patients successfully palliated by laser were treated with intraluminal radio-therapy. The combination of laser treatment with intraluminal radiotherapy provides good palliation and may reduce the need for repeated endoscopic treatment. Fibrous stricture formation is a common complication. (Author)

204

Calcifying fibrous pseudotumor of mediastinum--a case report.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This report presents a case of calcifying fibrous pseudotumor arising in the posterior mediastinum of a 54-year-old woman. The histopathologic features of this case were identical to that of calcifying fibrous pseudotumor first designated in 1993. It is a distinctive benign fibrous lesion characterized by the presence of characteristics psammomatous or dystrophic calcification, abundant hyalinized collagen and lymphoplasmacytic cell infiltrate. Immunohistochemically most of the scattered fibr...

Jeong, H. S.; Lee, G. K.; Sung, R.; Ahn, J. H.; Song, H. G.

1997-01-01

205

Intramedullary Solitary Fibrous Tumor of Cervicothoracic Spinal Cord  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Solitary fibrous tumor is rare benign mesenchymal neoplasm. The spinal solitary fibrous tumor is extremely rare. The authors experienced a case of intramedullary solitary fibrous tumor of cervicothoracic spinal cord in a 48-year-old man with right lower extremity sensory disturbance. Spinal MRI showed intradural mass lesion in the level of C7-T1, the margin between the spinal cord and tumor was not clear on MRI. A Left unilateral laminectomy and mass removal was performed. Intra operative fin...

Hwang, Ui Seung; Kim, Sung Bum; Jo, Dae Jean; Kim, Sung Min

2014-01-01

206

Solitary fibrous tumor of the infratemporal fossa: A case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

First described as a pleural neoplasm, the solitary fibrous tumor (fibrous mesothelioma) has been reported in a number of extrapulmonary sites, including the Head-Neck region. In the Head-Neck region, it has been described in the sinonasal tract, epiglottis, parapharyngeal, retropharyngeal spaces, parotid and infratemporal fossa. We present the second case of solitary fibrous tumor of infratemporal fossa described in world literature. A complete excision was achieved by transmaxillary approach.

Naresh, K. Panda; Parida Pradipta, K.; Mahesha, V.; Ashim, Das

2007-01-01

207

Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma  

Science.gov (United States)

Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Rhabdomyosarcoma; Adult Synovial Sarcoma; Gastrointestinal Stromal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Adult Soft Tissue Sarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

2014-08-26

208

Monostotic fibrous dysplasia of the ribs  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fibrous dysplasia (FD) is a sporadic benign skeletal disorder that can affect one bone (monostotic form) or multiple bones (polyostotic bone). Around 6–20% of monostotic FD occurs in the ribs. The objective of this study was to report our experience in the management of the monostotic FD of the ribs. Between January 2004 and December 2009, seven cases of FD of the rib (six men and one woman, mean age 30.4 years, range 17–40 years) were operated on. The patients were evaluated with plain r...

Traibi, Akram; El Oueriachi, Faycal; El Hammoumi, Massine; Al Bouzidi, Abderahman; Kabiri, El Hassane

2012-01-01

209

Cylindrical concave body of composite fibrous material  

International Nuclear Information System (INIS)

The invention is concerned with a cylindrical concave body of compound fibrous material which is intended to be exposed to high rotation speeds around its own longitudinal axis. The concave body in question has at least one layer of fibrils that are interwoven and enclose an identical angle with the longitudinal axis of the concave body in both directions. The concave body in question also has at least a second layer of fibrils that run in the direction of the circumference and are fitted radially to the outside. The cylindrical concave body of the invention is particularly well suited for application as a rotor tube in a gas ultra-centrifuge

210

Maligne Hypertonie  

Directory of Open Access Journals (Sweden)

Full Text Available Die maligne Hypertonie bezeichnet eine ausgeprägte arterielle Hypertonie mit neuroretinalen Symptomen und rasch progredienter Niereninsuffizienz. Sie kann sich sowohl de novo in bisher normotensiven Personen als auch bei bereits vorbestehender Hypertonie entwickeln. Seit der Einführung moderner potenter antihypertensiver Medikamente und der Option der Hämodialyse kam es zu einer signifikanten Reduktion der Morbidität und Mortalität. Die spezifische Behandlung hängt vom führenden klinischen Symptom ab, aber in den meisten Fällen wird eine Standardtherapie mit Urapidil intravenös bevorzugt. Die folgende Arbeit basiert auf einem Überblicksartikel von Guzman et al. und wurde mit den wichtigsten Studien der vergangenen Jahre auf diesem Gebiet ergänzt. Sie umfasst Pathophysiologie, klinische Präsentation, therapeutische Optionen und die Folgen der malignen Hypertonie.

Rosenkranz AR

2009-01-01

211

Sampling Citrus Fibrous Roots and Tylenchulus semipenetrans.  

Science.gov (United States)

Sampling precision was investigated for Tylenchulus semipenetrans juveniles and males in soil and females from roots and for citrus fibrous root mass density. For the case of two composite samples of 15 cores each, counts of juvenile and male nematodes were estimated to be within 40% of mu, at P 1,500 nematodes/100 cm(3) soil. A similar level of alpha was estimated for measurements of fibrous root mass density, but at a precision level of 25% of mu. Densities of female nematodes were estimated with less precision than juveniles and males. Precision estimates from a general sample plan derived from Taylor's Power Law were in good agreement with estimates from individual orchards. Two aspects involved in deriving sampling plans for management advisory purposes were investigated. A minimum of five to six preliminary samples were required to appreciably reduce bias toward underestimation of sigma. The use of a Student's t value rather than a standard normal deviate in formulae to estimate sample size increased the estimates by an average of three units. Cases in which the use of z rather than Student's t is appropriate for these formulae are discussed. PMID:19279914

Duncan, L W; El-Morshedy, M M; McSorley, R

1994-12-01

212

Craniofacial fibrous dysplasia: Surgery and literature review  

Science.gov (United States)

Objective: To highlight the clinical and radiologic features and management of craniofacial fibrous dysplasia with review of literature. Materials and Methods: A retrospective review of 6 patients who underwent surgical treatment in a tertiary healthcare centre was done using the parameters of patients' details, clinical features, radiological findings, management and postoperative review. Results: Of the six patients, 3 females and 2 males were in the 2nd decade of life and 1 male in the 1st decade of life. The disease was restricted to maxilla in 3 patients, involved the temporal and frontal bones in addition to maxilla in one, involved the frontal bone in one patient and involved frontal and parietal bones in one patient. The primary reason for seeking treatment in all the 6 cases was facial deformity. There was absence of pain in all 6 cases. For surgical treatment in all three cases involving the maxilla, the approach was intraoral while bicoronal approach was used for the other three cases. Treatment consisted of surgical contouring and reshaping the area. All cases were followed up over a period of 2 years with no signs of recurrence. Conclusion: Treatment of craniofacial fibro-osseous lesions is highly individualized. Most cases of craniofacial fibrous dysplasia manifest as swellings that cause facial deformity and surgical recontouring after cessation of growth seems to provide the best results. PMID:23662263

Menon, Suresh; Venkatswamy, Srihari; Ramu, Veena; Banu, Khurshida; Ehtaih, Sham; Kashyap, Vinay M.

2013-01-01

213

Imaging Findings of Fibrous Hamartoma of Infancy  

International Nuclear Information System (INIS)

We wanted to evaluate the imaging findings of fibrous hamartoma of infancy (FHI). We retrospectively reviewed the clinical presentation and the sonographic (n = 5) and CT (n = 3) findings of 5 cases of surgically/pathologically confirmed FHI. The sonographic findings were evaluated according to the location, size, internal echogenicity and vascularity. The CT findings were evaluated according to the attenuation of the mass on both the pre- (n = 3) and postcontrast (n = 2) scans. The image findings were correlated with the pathologic findings. The mean age was 14.8 months (range, 7 months - 3 years). The location of lesions was all in the fatty layer of the back (n = 4) and upper arm (n = 1). All the lesions demonstrated-hypertrichosis on the overlying skin. The lesions measured 31.2 mm in the longest diameter (range: 18 mm - 50 mm). The sonographic findings were purely solid, heterogeneously hyperechoic and hypovacular for all the cases. The internal architecture revealed a 'layering' appearance (n = 3). The CT findings demonstrated isoattenuation, as compared to the adjacent muscle on both the pre- and postcontrast CT scans. The pathologic correlation demonstrated a characteristic 'organoid' mixture of fibrous, mucoid and fatty tissues in all cases. The diagnosis of FHI can be suggested by the sonographic findings of a superficially located, heterogeneous solid mass with a 'layering' appearance in the fatty layer of the back or arms of infants with local hypertrochosor arms of infants with local hypertrochosis on the overlying skin

214

Intermittent respiratory obstruction secondary to a solitary fibrous tumour.  

Science.gov (United States)

There have been fourteen cases of solitary fibrous tumour reported as originating from the paranasal sinuses. Here we report a case of solitary fibrous tumour that involved the right nasal cavity with extension into the oropharynx causing stertor and intermittent respiratory obtruction. Histopathology examination revealed the tumuor cells expressed CD34 turnout marker. PMID:17243534

Shashinder, S; Kuljit, S; Rahmat, O; Usha, D A; Gopala, G K

2006-10-01

215

Marfan syndrome with multiseptate pneumothorax and mandibular fibrous dysplasia  

Directory of Open Access Journals (Sweden)

Full Text Available We describe a rare case of pneumothorax due to Marfan syndrome associated with fibrous dysplasia of the mandible. Marfan syndrome and fibrous dysplasia were possibly due to a common etiological factor. The association between the two and other tumors described in literature related to Marfan syndrome is discussed.

Kate A

2009-01-01

216

Fibrous microcapsules and methods of assembly and use thereof  

Energy Technology Data Exchange (ETDEWEB)

The present invention relates to assembly of peptide amphiphiles and biopolymers into fibrous microcapsules, and uses thereof. In particular, the present invention provides devices, compositions, and methods for interfacial self-assembly of peptide amphiphiles and biopolyments into fibrous microcapsules, and uses thereof.

Stupp, Samuel; Rozkiewicz, Dorota

2015-01-27

217

[Malignant hyperthermia].  

Science.gov (United States)

Malignant hyperthermia (MH) is a rare hereditary, mostly subclinical myopathy. Trigger substances, such as volatile anesthetic agents and the depolarizing muscle relaxant succinylcholine can induce a potentially fatal metabolic increase in predisposed patients caused by a dysregulation of the myoplasmic calcium (Ca) concentration. Mutations in the dihydropyridine ryanodine receptor complex in combination with the trigger substances are responsible for an uncontrolled release of Ca from the sarcoplasmic reticulum. This leads to activation of the contractile apparatus and a massive increase in cellular energy production. Exhaustion of the cellular energy reserves ultimately results in local muscle cell destruction and subsequent cardiovascular failure. The clinical picture of MH episodes is very variable. Early symptoms are hypoxia, hypercapnia and cardiac arrhythmia whereas the body temperature rise, after which MH is named, often occurs later. Decisive for the course of MH episodes is a timely targeted therapy. Following introduction of the hydantoin derivative dantrolene, the previously high mortality of fulminant MH episodes could be reduced to well under 10?%. An MH predisposition can be detected using the invasive in vitro contracture test (IVCT) or mutation analysis. Few elaborate diagnostic procedures are in the developmental stage. PMID:25384957

Metterlein, T; Schuster, F; Graf, B M; Anetseder, M

2014-12-01

218

Nonlinear analysis of laminated fibrous composites  

International Nuclear Information System (INIS)

A computerized analysis of the nonlinear behavior of fibrous composite laminates including axial loading, thermal loading, temperature dependent properties, and edge effects is presented. Ramberg--Osgood approximations are used to represent lamina stress--strain behavior, and percent retention curves are employed to model the variation of properties with temperature. Balanced, symmetric laminates comprised of either boron/epoxy, graphite/epoxy, or borsic--aluminum are analyzed using a quasi-three-dimensional finite element analysis. Results are presented for the interlaminar stress distributions in cross-ply, angle-ply, and more complex laminates. Nonlinear stress--strain curves for a variety of composite laminates in tension and compression are obtained and compared to other existing theories and experimental results

219

Symptomatic fibrous lunato-triquetral coalition  

International Nuclear Information System (INIS)

In general, carpal coalitions are considered to be asymptomatic. Incomplete separated joints and associated changes similar to osteoarthritis and pseudoarthrosis are known as possible causes of wrist pain. We present the clinical history, plain-film, and MR imaging findings of two patients with symptomatic fibrous lunato-triquetral coalition. Conventional films disclosed a narrowed space between the lunate and triquetral bone with cysts and sclerosis similar to pseudoarthrosis. Magnetic resonance imaging showed bone marrow edema adjacent to the incomplete separated lunato-triquetral joint and Gd-DTPA enhancing fibrovascular tissue in the synovium and subarticular cysts, explaining the pain over the ulnar-sided wrist. Patients with congenital lunato-triquetral coalition may poorly tolerate stress loading or trauma, resulting in a symptomatic state similar to degenerative arthritis or pseudoarthrosis, which is demonstrated by enhanced MR imaging. (orig.)

220

Symptomatic fibrous lunato-triquetral coalition  

Energy Technology Data Exchange (ETDEWEB)

In general, carpal coalitions are considered to be asymptomatic. Incomplete separated joints and associated changes similar to osteoarthritis and pseudoarthrosis are known as possible causes of wrist pain. We present the clinical history, plain-film, and MR imaging findings of two patients with symptomatic fibrous lunato-triquetral coalition. Conventional films disclosed a narrowed space between the lunate and triquetral bone with cysts and sclerosis similar to pseudoarthrosis. Magnetic resonance imaging showed bone marrow edema adjacent to the incomplete separated lunato-triquetral joint and Gd-DTPA enhancing fibrovascular tissue in the synovium and subarticular cysts, explaining the pain over the ulnar-sided wrist. Patients with congenital lunato-triquetral coalition may poorly tolerate stress loading or trauma, resulting in a symptomatic state similar to degenerative arthritis or pseudoarthrosis, which is demonstrated by enhanced MR imaging. (orig.) With 2 figs., 23 refs.

Staebler, A.; Glaser, C.; Reiser, M. [Department of Diagnostic Radiology, Ludwig Maximilians University of Munich (Germany); Resnick, D. [Department of Radiology, Veterans Administration Medical Center, San Diego, CA (United States)

1999-10-01

 
 
 
 
221

Fibrous metaphyseal defect (fibrous cortical defect, non-ossifying fibroma). Pt. 2  

International Nuclear Information System (INIS)

FMD, whether in the stage of a fibrous cortical defect or a non-ossifying fibroma, possesses very characteristic radiological appearances which rarely make it necessary to resort to biopsy. In order to avoid mistakes, it is necessary to observe strictly the known radiological features: metaphyseal position, clearcut relationship to the cortex, well defined margins, maximal size 6 to 7 cm., presence during growth, rarely observed in the upper extremity. The differential diagnosis, which needs to be considered only rarely, is discussed. (orig.)

222

Malignant hyperthermia  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Malignant hyperthermia (MH is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stresses such as vigorous exercise and heat. The incidence of MH reactions ranges from 1:5,000 to 1:50,000–100,000 anesthesias. However, the prevalence of the genetic abnormalities may be as great as one in 3,000 individuals. MH affects humans, certain pig breeds, dogs, horses, and probably other animals. The classic signs of MH include hyperthermia to marked degree, tachycardia, tachypnea, increased carbon dioxide production, increased oxygen consumption, acidosis, muscle rigidity, and rhabdomyolysis, all related to a hypermetabolic response. The syndrome is likely to be fatal if untreated. Early recognition of the signs of MH, specifically elevation of end-expired carbon dioxide, provides the clinical diagnostic clues. In humans the syndrome is inherited in autosomal dominant pattern, while in pigs in autosomal recessive. The pathophysiologic changes of MH are due to uncontrolled rise of myoplasmic calcium, which activates biochemical processes related to muscle activation. Due to ATP depletion, the muscle membrane integrity is compromised leading to hyperkalemia and rhabdomyolysis. In most cases, the syndrome is caused by a defect in the ryanodine receptor. Over 90 mutations have been identified in the RYR-1 gene located on chromosome 19q13.1, and at least 25 are causal for MH. Diagnostic testing relies on assessing the in vitro contracture response of biopsied muscle to halothane, caffeine, and other drugs. Elucidation of the genetic changes has led to the introduction, on a limited basis so far, of genetic testing for susceptibility to MH. As the sensitivity of genetic testing increases, molecular genetics will be used for identifying those at risk with greater frequency. Dantrolene sodium is a specific antagonist of the pathophysiologic changes of MH and should be available wherever general anesthesia is administered. Thanks to the dramatic progress in understanding the clinical manifestation and pathophysiology of the syndrome, the mortality from MH has dropped from over 80% thirty years ago to less than 5%.

Pollock Neil

2007-04-01

223

F-18 FDG PET-positive Fibrous Dysplasia in a Patient with Intestinal Non-Hodgkin's Lymphoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fibrous dysplasia (FD) is a common benign bone disorder of an unclear etiology. It is known that FD can appear without an increased FDG uptake on F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). However, there are also several reports that FD showed increased FDG uptake and this mimicked malignant bone involvement on FDG-PET. Herein we describe a case of biopsy-proven FDG-PET positive FD in a patient with intestinal non-Hodgkin's lymphoma (NHL). A 45-year...

Kim, Mi; Kim, Hyeong Su; Kim, Jung Han; Jang, Joo Hyun; Chung, Kook Jin; Shin, Mi Kyung; Hwang, Hee Sung; Kim, Byung Chun; Jung, So Young

2009-01-01

224

Solitary fibrous tumor of the pleura presenting with syncope episodes when coughing  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Solitary fibrous tumor of the pleura is a rarely encountered clinical entity which may have different clinical pictures. Although the majority of these neoplasms have a benign course, the malignant form has also been reported. Case presentation We herein describe a case of 72 year-old man with head, facial, and thoracic traumas caused by neurally-mediated situational syncope when coughing. The diagnostic work-up including chest x-ray, CT and PET, revealed a large solitary mass of the left hemithorax. Radical surgical resection of the mass was performed through a left lateral thoracotomy and completed with a wedge resection of the lingula. Hystological examination of the surgical specimen showed an encapsulated mass measuring 12 ? 11.5 × 6 cm consistent with a solitary fibrous tumor of the pleura. It's surgical removal definitively resolved the neurologic manifestations. The patient had no postoperative complications. At two years follow-up the patient is free from recurrence and without clinical manifestations. Conclusion In our case its resection definitively resolved the episodes of situational syncope due, in our opinion, to the large thoracic mass compressing the phrenic nerve

Ciulla Michele M

2008-08-01

225

Polyostotic fibrous dysplasia of the ribs: An unusual cause of chest pain and dyspnea  

Directory of Open Access Journals (Sweden)

Full Text Available Sevket Ozkaya1, Serhat Findik2, Hasan Demir1, Canan Yuksel3, Atilla Guven Atici21Samsun Chest Disease and Chest Surgery Hospital, Samsun, Turkey; 2Ondokuz Mayis University, Faculty of Medicine, Department of Pulmonary Medicine, Samsun, Turkey; 3Samsun Pathology and Cytology Centre, Samsun, TurkeyAbstract: Fibrous dysplasia is a benign bony abnormality that may be monostotic or polyostotic and is not included in the differential diagnosis of chest pain and dyspnea, since it is typically asymptomatic. A 36-year-old man presented with left-sided chest pain and dsypnea for three months. Chest X-ray and chest computed tomography scan revealed a large solid mass arising from the anterior parts of the left fourth, fifth, and sixth ribs and compressing the adjacent lung parenchyma. The tumor was completely removed surgically and histopathologic examination was consistent with fibrous dysplasia without malignant transformation. This report demonstrates that polyostotic dysplasia of the ribs may cause chest pain and dyspnea and present radiographically as a large mass.Keywords: chest wall, imaging, computed tomography, thoracotomy

Sevket Ozkaya

2009-08-01

226

Reflective Coating on Fibrous Insulation for Reduced Heat Transfer  

Science.gov (United States)

Radiative heat transfer through fibrous insulation used in thermal protection systems (TPS) is significant at high temperatures (1200 C). Decreasing the radiative heat transfer through the fibrous insulation can thus have a major impact on the insulating ability of the TPS. Reflective coatings applied directly to the individual fibers in fibrous insulation should decrease the radiative heat transfer leading to an insulation with decreased effective thermal conductivity. Coatings with high infrared reflectance have been developed using sol-gel techniques. Using this technique, uniform coatings can be applied to fibrous insulation without an appreciable increase in insulation weight or density. Scanning electron microscopy, Fourier Transform infrared spectroscopy, and ellipsometry have been performed to evaluate coating performance.

Hass, Derek D.; Prasad, B. Durga; Glass, David E.; Wiedemann, Karl E.

1997-01-01

227

Localised fibrous mesothelioma arising in an intralobar pulmonary sequestration.  

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A localised fibrous mesothelioma arising from an intralobar lung sequestration occurred in a 64 year old Turkish woman. This appears to be the first report of a mesothelioma occurring within a pulmonary sequestration.

Paksoy, N.; Demircan, A.; Altiner, M.; Artvinli, M.

1992-01-01

228

Ehlers-Danlos syndrome with monostotic fibrous dysplasia  

Directory of Open Access Journals (Sweden)

Full Text Available An unusual case of Ehlers-Danlos syndrome with monostotic fibrous dysplasia of the humorus is presented. The other orthopae-dic manifestations, its complications and associated features are re-viewed and summarised.

Rao A

1979-01-01

229

MRI of fibrous cortical defect and non-ossifying fibroma  

Energy Technology Data Exchange (ETDEWEB)

Fibrous cortical defect and non-ossifying fibroma are the benign fibrous lesions of bone commonly involving children. Their diagnosis is usually done with radiography, and MR examinations are rarely performed. We evaluated MRI findings of 11 lesions in 10 cases of fibrous cortical defect and non-ossifying fibroma. Signal intensity of the lesions was varied and large lesions (2 cm<) tended to show heterogeneous signal intensity on both T1-weighted and T2-weighted images corresponding to a mixture of components including fibrous tissue, hemosiderin and foam cells. MRI helps to delineate the extent of the involved bone and to assess the various histological components of the lesions. However, their diagnosis is basically made on the radiographic findings and the role of MRI is limited. (author)

Mishima, Yoshiko; Aoki, Takatoshi; Watanabe, Hideyuki; Nakata, Hajime; Hashimoto, Hiroshi; Nakamura, Toshitaka [Univ. of Occupational and Environmental Health, Kitakyushu, Fukuoka (Japan). School of Medicine

1999-02-01

230

Dedifferentiated liposarcoma with leukocytosis. A case report of G-CSF-producing soft-tissue tumors, possible association with undifferentiated liposarcoma lineage  

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Abstract Background Granulocyte-colony-stimulating factor (G-CSF) functions as a hematopoietic growth factor and it is responsible for leukocytosis. G-CSF-producing tumors associated with leukocytosis include various types of malignancies. Case presentation We report the case of a 72-year-old man with dedifferentiated liposarcoma characterized by dedifferentiated components of malignant fibrous histiocytoma (MFH)-like features in addition to well-differentiated ...

Matsuda Shuichi; Tanaka Kazuhiro; Yoshida Tatsuya; Matono Hiroshi; Sakamoto Akio; Oda Yoshinao; Iwamoto Yukihide

2007-01-01

231

Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcoma.  

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Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is difficult. Patients and Methods. Array-based comparative genomic hybridization (aCGH) was applied to 30 multiple STS of the extremities and the trunk wall from 13 patients. Different histotypes were present with malignant fibrous histiocytomas/undifferentiated pleomorphic sarcomas being the predominant su...

Åke Borg; Mef Nilbert; Anna Karlsson; Domanski, Henryk A.; Josefin Fernebro; Ana Carneiro; Anders Rydholm

2008-01-01

232

Head and Neck Soft Tissue Sarcoma  

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Sarcomas are malignant neoplasms originating from mesodermal tissues and constitute less than 1% of body’s tumors, including those of the head and neck region. 5–15% of adult sarcomas are in the head and neck region (20% from bones and cartilages and 80% in soft tissues). Commonly encountered sarcomas in the head and neck region are - osteosarcoma, rhabdomyosarcoma, malignant fibrous histiocytoma, fibrosarcoma and angiosarcoma. This article reviews the available literature on head and nec...

Aljabab, A. S.; Nason, R. W.; Kazi, R.; Pathak, K. A.

2011-01-01

233

Impregnated Fibrous Materials. Report of a Study Group on Impregnated Fibrous Materials  

International Nuclear Information System (INIS)

There has recently been renewed interest in the use of radiation from radioisotopes or particle accelerators to initiate and sustain chemical reactions. Particular attention is being paid to the production of wood-plastic composites, a process which is now a commercial reality with radiation competing against chemical methods to enhance the properties of wood. It has been reported that water repellancy, hardness, weathering, insect and chemical resistance, compressive, bending and shear strength can be significantly improved by the process, but so far there has been a limited commercial outlet for the product. Papers on this subject were presented at the International Atomic Energy Agency's Symposium on Industrial Uses of Large Radiation Sources, Salzburg, May 1963, and since then the Agency has been aware of the interest of developing countries in conducting research on wood and other fibrous materials as a means of further exploiting natural resources. It was felt that some attempt should be made to co-ordinate, on a regional basis, the work being done in this field and at the same time review the world status, including the associated technology in such areas as monomer-polymer chemistry and impregnation techniques where they are directly related to this work. Because of the wide range of fibrous materials being studied there, Asia and the Far East was chosen as the most representative area and 39 participants from 13 countries, and from international organizations, met in Bangkok from 20 to 24 November 1967 to assess the potential of impregnated fibrous materials. This report is a record of the meeting and is based not only on work performed both inside and outside the region but also on details of the resources and industries in the area

234

Chondrosarcoma occurring in a patient with polyostotic fibrous dysplasia  

Energy Technology Data Exchange (ETDEWEB)

A 36-year-old white man with polyostotic fibrous dysplasia was found to have a high-grade chondrosarcoma arising from the left ilium. Although a left hemipelvectomy was performed, the patient subsequently developed sacral and pulmonary metastases and succumbed to his disease. This patient represents the first documented example of an unequivocally high-grade chondrosarcoma arising in an area of fibrous dysplasia without prior irradiation.

De Smet, A.A.; Travers, H.; Neff, J.R.

1981-12-01

235

Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture  

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As the field of tissue engineering evolves, there is a tremendous demand to produce more suitable materials and processing techniques in order to address the requirements (e.g., mechanics and vascularity) of more intricate organs and tissues. Electrospinning is a popular technique to create fibrous scaffolds that mimic the architecture and size scale of the native extracellular matrix. These fibrous scaffolds are also useful as cell culture substrates since the fibers can be used to direct ...

Ifkovits, Jamie L.; Sundararaghavan, Harini G.; Burdick, Jason A.

2009-01-01

236

Malignant lymphoma in central nervous system (CNS)  

International Nuclear Information System (INIS)

A 71-year-old male was admitted to Kohka Public Hospital on January 4, 1980, because of frequent vomiting and recent memory loss. Two weeks before admission upper G-I series showed no abnormalities. Physical and neurological examinations revealed no abnormalities except for slightly apathetic appearance and recent memory loss. Mild pleocytosis and marked increase of protein in CSF were observed. CT scan on January 17 showed high density areas in both medial sides of temporal lobes with remarkable contrast enhancement. His memory and, consciousness disturbances gradually aggravated, accompanied by abnormal density spreading around the ventricle walls like ventriculitis. He was transfered to Kyoto University Hospital on March 17, and malignant lymphoma was diagnosed on the basis of CSF cytology. Radiation and chemotherapy alleviated the CNS involvement and he regained normal mental function. On June 16, he developed pneumonia followed by status epilepticus. Autopsy findings revealed no lymphoid cell infiltration, but fibrous tissues in both hippocampal gyri and lymphomatous cells in the liver, which could not be suspected on clinical examinations. Apparent malignant lymphoma cells were not found in lymph nodes. This case indicated peculiar evolution of malignant lymphoma from liver to CNS or vice versa. We could not decide which organ was primary. CT findings of this case was very interesting; they resembled ventriculitis, which simulate tumors such as medulloblastoma o simulate tumors such as medulloblastoma or ependymoma spreading under ependymal lining. (author)

237

Intracranial solitary fibrous tumor: Imaging findings  

International Nuclear Information System (INIS)

Objective: To study the neuroimaging features of intracranial solitary fibrous tumors (ISFTs). Materials and methods: Retrospective study of neuroimaging features of 9 consecutive histopathologically proven ISFT cases. Location, size, shape, density, signal intensity and gadolinium uptake were studied at CT and MRI. Data collected from diffusion-weighted imaging (DWI) (3 patients), perfusion imaging and MR spectroscopy (2 patients), and DSA (4 patients) were also analyzed. Results: The tumors most frequently arose from the intracranial meninges (7/9), while the other lesions were intraventricular. Tumor size ranged from 2.5 to 10 cm (mean = 6.6 cm). They presented multilobular shape in 6/9 patients. Most ISFTs were heterogeneous (7/9) with areas of low T2 signal intensity that strongly enhanced after gadolinium administration (6/8). Erosion of the skull was present in about half of the cases (4/9). Components with decreased apparent diffusion coefficient were seen in 2/3 ISFTs on DWI. Spectroscopy revealed elevated peaks of choline and myo-inositol. MR perfusion showed features of hyperperfusion. Conclusion: ISFT should be considered in cases of extra-axial, supratentorial, heterogeneous, hypervascular tumor. Areas of low T2 signal intensity that strongly enhance after gadolinium injection are suggestive of this diagnosis. Restricted diffusion and elevated peak of myo-inositol may be additional valuable features.

238

Intracranial solitary fibrous tumor: Imaging findings  

Energy Technology Data Exchange (ETDEWEB)

Objective: To study the neuroimaging features of intracranial solitary fibrous tumors (ISFTs). Materials and methods: Retrospective study of neuroimaging features of 9 consecutive histopathologically proven ISFT cases. Location, size, shape, density, signal intensity and gadolinium uptake were studied at CT and MRI. Data collected from diffusion-weighted imaging (DWI) (3 patients), perfusion imaging and MR spectroscopy (2 patients), and DSA (4 patients) were also analyzed. Results: The tumors most frequently arose from the intracranial meninges (7/9), while the other lesions were intraventricular. Tumor size ranged from 2.5 to 10 cm (mean = 6.6 cm). They presented multilobular shape in 6/9 patients. Most ISFTs were heterogeneous (7/9) with areas of low T2 signal intensity that strongly enhanced after gadolinium administration (6/8). Erosion of the skull was present in about half of the cases (4/9). Components with decreased apparent diffusion coefficient were seen in 2/3 ISFTs on DWI. Spectroscopy revealed elevated peaks of choline and myo-inositol. MR perfusion showed features of hyperperfusion. Conclusion: ISFT should be considered in cases of extra-axial, supratentorial, heterogeneous, hypervascular tumor. Areas of low T2 signal intensity that strongly enhance after gadolinium injection are suggestive of this diagnosis. Restricted diffusion and elevated peak of myo-inositol may be additional valuable features.

Clarencon, Frederic, E-mail: fredclare5@msn.com [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Bonneville, Fabrice [Department of Neuroradiology, Hopital Rangueil, Toulouse University Hospital, 31000 Toulouse (France); Rousseau, Audrey [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Galanaud, Damien [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Kujas, Michele [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Naggara, Olivier [Department of Neuroradiology, St Anne Hospital, 75014 Paris (France); Cornu, Philippe [Department of Neurosurgery, Pitie-Salpetriere Hospital (France); Chiras, Jacques [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France)

2011-11-15

239

Ultrasonographic features of fibrous hamartoma of infancy  

International Nuclear Information System (INIS)

To review imaging features of fibrous hamartoma of infancy (FHI), focusing on ultrasonography (US) findings. We retrospectively reviewed pediatric patients who were diagnosed with pathologically confirmed FHI in two children's hospitals from 2004 to 2013. Imaging features of US, Doppler US, and magnetic resonance imaging (MRI) were evaluated. Thirteen pediatric patients (M:F = 7:6; age 5-22 months, mean 11.3 months) were included. Mean lesion size was 3.2 cm (range, 0.7-8.0 cm). The tumors were located in the back (n = 4), scrotum (n = 2), scalp, shoulder, axilla, forearm, intergluteal cleft, inguinal area, and thigh. US was performed in 11 patients. With the exception of two scrotal masses, all masses were located in the dermal and subcutaneous layer. All masses demonstrated heterogeneous hyperechogenicity with a ''serpentine pattern'' of intervening hypoechoic portions in the hyperechoic mass. The margins were ill-defined (n = 9) or lobulated (n = 2). Doppler US was performed in nine patients and showed no (n = 6) or minimal (n = 3) vascularity. MRI was performed in five patients and the masses showed heterogeneous signal intensity with the presence of fat on T1- and T2-weighted images. FHI is a tumor that is typically located in the dermal and subcutaneous layer in young children less than 2 years old and presents as a heterogeneously hyperechoic mass with a ''serpentine pattern'' and ill-defined or lobulated margin on US and no remarkable vascularity on Doppler US. (orig.)

240

Compressibility of air in fibrous materials  

DEFF Research Database (Denmark)

The dynamic compressibility of air in fibrous materials has been computed for two assumed configurations of fibers which are close to the geometry of real fiber materials. Models with parallel cylinders placed in a regular square lattice and placed randomly are treated. For these models the compressibility is computed approximately from the diameter and mean distances between cylinders. This requires calculation of the air temperature, which is calculated for cylinders in a regular lattive by the Wigner-Seitz cell approximation. In the case of random placement, the calculation is done by a summation over thermal waves from all fibers, and by a self-consistent procedure. Figuren of the compressibility in the frequency range 10-100 000 Hz, are given for diameter of the cylinders of 6.8 µm, and mean distances between them from 50 to 110 µm, which corresponds to glass wool with a density of 40 to 16 kg/m3. When the theoretical values for random placement were compared with measurements, it turned out that the random model could not describe the experimental data. However, they could be described accurately by assuming that the fibers have a tendency to form pairs.

Tarnow, Viggo

1996-01-01

 
 
 
 
241

Simulation and Analysis of Unbonded Nonwoven Fibrous Structures  

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Full Text Available In this work we report on our algorithm for generating 3-D virtual structures resembling un-bonded fibrous webs. The paper discusses short and infinitely long fibers, each emulating a category of nonwoven fibrous medium. The structure Solid Volume Fraction (SVF, being the most important characteristic of a fibrous porous medium, is calculated for different fiberwebs and discussed in details. It is shown that the SVF of the fibrous structures generated by our algorithm is independent of the basis weight. In other words, the porosity of the medium is only a function of the fiber properties – this is as expected. It is also demonstrated that by decreasing the fiber diameter while keeping other properties of the virtual fiberweb constant causes the SVF to decrease almost linearly. The same is not observed for the fiber rigidity. The capability of our algorithm for generating fibrous webs made up of layers of different fibers is demonstrated and their properties are discussed. The application of such virtual fibrous structures in modeling transport phenomena in nonwoven materials and their potential applications in load-deformation studies are discussed.

Behnam Pourdeyhimi

2006-11-01

242

Functional, malignant intrathoracic paraganglioma.  

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This paper describes a case of functional, malignant branchiomeric paraganglioma, the third such to be reported. The patient presented with malignant hypertension and symptoms suggestive of excessive catecholamine secretion.

Aggarwal, P.; Wali, J. P.; Venugopal, P.; Khosla, A.; Tickoo, S. K.

1989-01-01

243

Malignant teratoma (image)  

Science.gov (United States)

A malignant teratoma is a type of cancer consisting of cysts that contain one or more of the three primary embryonic germ layers: ectoderm, mesoderm, and endoderm. Because malignant teratomas have usually spread by the time of diagnosis, ...

244

Rare primary malignant tumors of the liver  

International Nuclear Information System (INIS)

Angiosarcoma, epithelioid hemangio-endothelioma (EHE) and fibrolamellar carcinoma (FLC) are far less frequent malignant primary tumors of the liver than liver-cell carcinoma, and usually do not occur in a chronic liver disease. Their diagnosis is histological but a few radiological criteria are suggestive: in younger subjects, a solitary, hypervascularized mass containing calcifications and/or a central fibrous scar suggests an FLC; nodular lesions merging into patches, scattered about the periphery, containing calcified clusters and showing a low and late contrast enhancement after injections suggest an EHE; lastly, in case of occupational exposure, an heterogeneous, hypervascularized mass with a centripetal blush but containing central areas that are opacified early should suggest angiosarcoma. (4 figs)

245

Malignant penile horn.  

Science.gov (United States)

The fifth case of carcinoma within a penile horn is reported in a patient who also had erythroplasia of Queyrat of the glans penis. Penile horns should be considered as pre-malignant lesions, since a third of them undergo malignant change and they may be associated with a pre-malignant condition of the glans penis. PMID:926252

Raghavaiah, N V; Soloway, M S; Murphy, W M

1977-12-01

246

A call to expand regulation to all carcinogenic fibrous minerals  

Science.gov (United States)

The regulatory term "asbestos" groups only the six fibrous minerals that were commercially used among approximately 400. The carcinogenicity of these six regulated minerals has been largely demonstrated and is related to fiber structure, fiber length/diameter ratio, and bio-persistence. From a public perception, the generic term "asbestos" refers to the fibrous minerals that cause asbestosis, mesothelioma and other cancers. However, other non-regulated fibrous minerals are potentially as dangerous as the regulatory asbestos because they share similar physical and chemical properties, epidemiological studies have demonstrated their relationship with asbestos-related diseases, and both in vitro and in vivo experiments have established the toxicity of these minerals. For example, the non-regulated asbestiform winchite and richterite minerals that contaminated the vermiculite mined from Libby, Montana, (USA) were associated with mesothelioma, lung cancer and asbestosis observed among the area's residents and miners. Many other examples of non-regulated carcinogenic fibrous minerals include, but are not limited to, antigorite, arfvedsonite, balangeroite, carlosturanite, erionite, fluoro-edenite, hornblende, mordenite, palygorskite, and sepiolite. To propose a regulatory definition that would provide protection from all carcinogenic fibers, we have conducted an interdisciplinary literature review to compare the characteristics of "asbestos" and of non-regulated mineral fibers that relate to carcinogenicity. We specifically studied two non-regulated fibrous minerals that are associated with asbestos-related diseases: the serpentine antigorite and the zeolite erionite. Both examples underscore the problem of regulation based on commercial, rather than scientific principles: 1) the occurrence of fibrous antigorite in materials used to pave roads has been correlated with high mesothelioma rates in New Caledonia. Antigorite was also the cause of asbestosis in Poland, and in vitro and in vivo studies have shown its toxic and carcinogenic properties; 2) the carcinogenic properties of erionite have been demonstrated, and erionite has been associated with a mesothelioma epidemic in Anatolia, Turkey. Erionite is also widespread in areas of north central USA, where it is contained in gravel paving stone, and is cause for concern due to increased commercial traffic. Numerous studies have shown that non-regulated fibrous materials pose similar health hazards to regulated "asbestos". An increase in human activities in areas where these fibrous minerals are present, such as in surficial rock and soil, will result in the generation of airborne dust, exposing people to carcinogenic fibers. The current limited regulation leads people to believe that only the six mineral fibers referred to as "asbestos" are dangerous. We propose that fibrous minerals should be regulated as a single group, as they have similar deleterious effects on the human body. Regulations would be simplified and more effective if they embrace all carcinogenic fibrous minerals.

Baumann, F.; Steele, I.; Ambrosi, J.; Carbone, M.

2013-05-01

247

Diffuse reflectance spectroscopy of fibrous proteins.  

Science.gov (United States)

UV-visible diffuse reflectance (DR) spectra of the fibrous proteins wool and feather keratin, silk fibroin and bovine skin collagen are presented. Natural wool contains much higher levels of visible chromophores across the whole visible range (700-400 nm) than the other proteins and only those above 450 nm are effectively removed by bleaching. Both oxidative and reductive bleaching are inefficient for removing yellow chromophores (450-400 nm absorbers) from wool. The DR spectra of the four UV-absorbing amino acids tryptophan, tyrosine, cystine and phenylalanine were recorded as finely ground powders. In contrast to their UV-visible spectra in aqueous solution where tryptophan and tyrosine are the major UV absorbing species, surprisingly the disulphide chromophore of solid cystine has the strongest UV absorbance measured using the DR remission function F(R)(?). The DR spectra of unpigmented feather and wool keratin appear to be dominated by cystine absorption near 290 nm, whereas silk fibroin appears similar to tyrosine. Because cystine has a flat reflectance spectrum in the visible region from 700 to 400 nm and the powder therefore appears white, cystine absorption does not contribute to the cream colour of wool despite the high concentration of cystine residues near the cuticle surface. The disulphide absorption of solid L: -cystine in the DR spectrum at 290 nm is significantly red shifted by ~40 nm relative to its wavelength in solution, whereas homocystine and lipoic acid showed smaller red shifts of 20 nm. The large red shift observed for cystine and the large difference in intensity of absorption in its UV-visible and DR spectra may be due to differences in the dihedral angle between the crystalline solid and the solvated molecules in solution. PMID:22218994

Millington, Keith R

2012-09-01

248

Anogenital malignancies and pre-malignancies.  

Science.gov (United States)

Anogenital pre-malignancies and malignancies are frequently encountered. Aetiopathogenetically, human papillomavirus (HPV) infection plays a critical role. However, there is a variable degree of association of HPV infection with the development of anogenital malignancies. In this context, the high level of clinically unapparent HPV infection should be considered. Therefore, the question arises if the association with HPV is always causative. Besides HPV, pre-existent lichen sclerosus is also an important aetiopathologic factor in the development of anogenital malignancies. Common anogenital pre-malignancies comprise Bowen's disease (BD), Bowenoid papulosis (BP) and erythroplasia of Queyrat (EQ). From a clinical point of view, these are clearly different entities, but from a histopathological point of view, BD, BP and EQ are indistinguishable. They all represent forms of squamous intraepithelial neoplasia (IN). Intraepithelial neoplasia (IN) is not only restricted to squamous variants, but also includes non-squamous IN, Paget's disease (PD) and melanoma in situ. The risk of developing anogenital (pre)malignancies or other tumours is higher in immunocompromised and immunodeficient patients, in particular those suffering from human immunodeficiency virus (HIV) infection. Such risk factors will affect treatment and follow-up modalities. Regarding prophylactic measures, a relatively recent but very important development is the availability of HPV vaccination on a large scale. Momentarily, the effects of such vaccination, on a population-based scale, are not yet clear but will become apparent in the near future. Management of anogenital pre-malignancies and malignancies should be tailor-made and may be organized in a multidisciplinary fashion. PMID:21272092

Henquet, C J M

2011-08-01

249

Recurring fibrous dysplasia of anthro maxillary with cranial base invasion  

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Full Text Available Introduction: Fibrous dysplasia is an osseous lesion with an unknown etiology. It is characterized by the osseous maturation insufficiency. It may affect any bone, but the affection of craniofacial bones is the most critical for otorhinolaryngology. Maxilla is the most affected facial bone and the orbitary invasion is an uncommon event. The symptoms are unspecific and for its low suspicion and uncommonness, the diagnosis is generally late. The monostotic form presents a slow growth and asymptomatic course and needs to be followed up. The polyostotic type has a progressive behavior and is associated to recurrence and complications. Objective: To present two cases of patients with fibrous dysplasia diagnosis and describe the clinical presentation, radiological findings and the treatment of this pathology. Cases Report: Two cases of fibrous dysplasia are reported, which initially presented unspecific symptomatology, but with characteristic radiologic signs. They were submitted to surgical treatment for resection of the lesions and evolved with frequent recurrences with extensive affection of the facial sinuses, one patient had cranial base invasion and frontal craniotomy was needed for tumoral excision. Final Comments: Fibrous dysplasia is an uncommon osteopathy. The tomography is the choice method for characterization of the tumoral expansion, and helps in the surgical planning. The surgical strategy is indicated for symptomatic lesions, functions alterations or anatomic disorders. This article describes two uncommon manifestations of recurrent fibrous dysplasia with an extensive affection of anthro maxillary, ethmoidal and sphenoid sinuses, in addition to orbitary and cranial base invasion.

Sousa, Kátia Maria Marabuco de

2009-09-01

250

Computed tomographic features of fibrous dysplasia of maxillofacial region  

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This study was to find the computed tomographic features of fibrous dysplasia of the maxillofacial region. All eight cases included in the study reported either to Government Dental College and Hospital or Nair Hospital Dental College, Mumbai between 2003 and 2009. The patients were prescribed computed tomogram in addition to conventional radiographs of maxillofacial region which were studied for characteristic features of fibrous dysplasia. The diagnosis of fibrous dysplasia was confirmed by histopathological report. All cases showed the ill-defined margins of lesions except in the region where the lesions were extending to cortex of the involved bone. Internal structure of all cases showed ground glass appearance. Four cases of maxillary lesion showed the displacement of maxillary sinus maintaining the shape of maxillary sinus. Two cases showed complete obliteration of maxillary sinus. Displacement of inferior alveolar canal did not follow any typical pattern in any of the cases but was displaced in different directions. The craniofacial type of fibrous dysplasia is as common as fibrous dysplasia of jaw. The margins, extent, internal structure and effect on surrounding structure are well detected on computed tomographic images.

Sontakke, Subodh Arun; Karjodka, Freny R [Nair Hospital Dental College, Mumba (India); Umarji, Hemant R [Government Dental College and Hospital, Mumbai (India)

2011-03-15

251

Symptomatic polyostotic fibrous dysplasia of the thoracic spine.  

Science.gov (United States)

We present a case of polyostotic fibrous dysplasia with limited involvement in thoracic spine and adjacent ribs. The patient underwent posterior instrumentation performed between Th3 and Th11 with pedicle screw system, followed by costotransversectomy of 7th and 8th costovertebral junctions and posterior spinal fusion for costal lesions. In the same operation, curettage was done for the lesion in Th6 vertebra and bone grafting and anterior total corpectomy were performed for Th7 and Th8 vertebrae. 360 degrees spinal fusion was done using titanium mesh as strut graft and autogenous rib grafts. Fibrous dysplasia occurs rarely in axial bones than peripheral bones. The cystic lesions in segments of the whole spine should be evaluated for the possibility of fibrous dysplasia with detailed radiographical examination and biopsy. PMID:16997601

Tezer, Mehmet; Erturer, Erden; Ozturk, Cagatay; Aydogan, Mehmet; Hamzaoglu, Azmi

2006-12-01

252

Magnetoelectric effects in multiferroic fibrous composite with imperfect interface  

International Nuclear Information System (INIS)

This paper investigates the magnetoelectroelastic responses of multiferroic fibrous composites with imperfectly bonded interface under longitudinal shear. The proposed imperfect interface model is a natural generalization of the shear lag (or the spring layer) model. By virtue of the complex variable method, we first consider the case where an isolated circular multiferroic fiber is imperfectly bonded to an infinite multiferroic matrix. Very concise expressions for the complex field potentials characterizing the magnetoelectroelastic fields inside and outside the circular fiber are obtained when the matrix is subjected to the remote uniform magnetoelectroelastic loading. The Mori-Tanaka mean-field method is then employed to derive the effective moduli of the multiferroic fibrous composite made of randomly distributed fibers reinforced to the matrix. Particularly we demonstrate that the interfacial imperfection in elasticity, electricity, and magnetism will always cause a significant reduction in the magnetoelectric coefficient of the BaTiO3-CoFe2O4 fibrous composite

253

Efficacy of trabectedin in metastatic solitary fibrous tumor  

Directory of Open Access Journals (Sweden)

Full Text Available Solitary fibrous tumor is a rare tumor type and has an unpredictable course. Local recurrence rate varies between 9 and 19 %, and rate of metastatic involvement between 0 and 36 %. It is characterized by a typical architecture and immuno-histochemistry tests. The most important prognostic factor is the complete resection of primary tumor. Treatment of recurrences is not clearly established. If a solitary fibrous tumor is too advanced to allow surgical resection, radiotherapy and chemotherapy may be used. The most often used drugs are doxorubicine andor ifosfamide. We report the case of man with metastatic solitary fibrous tumor treated with trabectedin, administered at a dose of 1.5 mg/m² every 3 weeks. After 3 cycles, metastases had significantly decreased. Recurrence of the disease was demonstrated 8 months after the start of trabectedin. This case shows that trabectedin is a possible treatment option.

Xavier Pivot

2011-07-01

254

Intramedullary solitary fibrous tumor of cervicothoracic spinal cord.  

Science.gov (United States)

Solitary fibrous tumor is rare benign mesenchymal neoplasm. The spinal solitary fibrous tumor is extremely rare. The authors experienced a case of intramedullary solitary fibrous tumor of cervicothoracic spinal cord in a 48-year-old man with right lower extremity sensory disturbance. Spinal MRI showed intradural mass lesion in the level of C7-T1, the margin between the spinal cord and tumor was not clear on MRI. A Left unilateral laminectomy and mass removal was performed. Intra operative finding, the tumor boundary was unclear from spinal cord and it had intramedullary and extramedullary portion. After surgery, patient had good recovery and had uneventful prognosis. Follow up spinal MRI showed no recurrence of tumor. PMID:25368773

Hwang, Ui Seung; Kim, Sung Bum; Jo, Dae Jean; Kim, Sung Min

2014-09-01

255

Focal Electroencephalography Rhythm Asymmetry due to Focal Skull Fibrous Dysplasia.  

Science.gov (United States)

An unusual pervasive and persistent asymmetry in background rhythm was found on surface electroencephalography (EEG) recordings in a 22 year old with new onset of generalized seizure activity. Radiographic correlation with computed tomography, positron emission tomography and bone scan imaging uncovered that the higher amplitude left frontal-parietal background activity was related to a circumscribed area of left frontal-parietal fibrous dysplasia affecting the skull. This case report emphasizes that the presumed higher electrical conductance of fibrous dysplasia lead to a greater transparency of normal background rhythms, and must be taken into account as a form of breach rhythm for accurate EEG interpretation. PMID:24987499

Meyer, Michael A

2014-04-22

256

Pedunculated malignant melanoma  

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Full Text Available Pedunculated malignant melanoma is a rare occurrence. A 29 year old woman presented with a pedunculated malignant melanoma on a congenital melanocytic naevus with halo. Pedunculated malignant melanoma is known to have a high incidence of metastasis. The absence of metastasis and the presence of halo, in the case presented, suggests, that the body?s immunological process may have arrested the spread of the melanoma.

Bhat Ramesha

1994-01-01

257

Factors Affecting the Impregnation of Bagasse and Other Far-Eastern Fibrous Materials  

International Nuclear Information System (INIS)

Natural fibrous materials contain a variety of natural oils or resinous compounds which partly retard the copolymerization of impregnated fibrous materials. Impregnation and gamma irradiation techniques are discussed with particular reference to bamboo and bagasse. (author)

258

Fibrous dysplasia of the jaws associated with secondary hyperparathyroidism: a case report  

International Nuclear Information System (INIS)

There have been few reports on fibrous dyplasia associated with secondary hyperparathyroidism. We report a case of a hemodialysis patient with secondary hyperparathyroidism concomitant with fibrous dysplasia of the jaws causing an abnormal deformity

259

Fibrous dysplasia of the jaws associated with secondary hyperparathyroidism: a case report  

Energy Technology Data Exchange (ETDEWEB)

There have been few reports on fibrous dyplasia associated with secondary hyperparathyroidism. We report a case of a hemodialysis patient with secondary hyperparathyroidism concomitant with fibrous dysplasia of the jaws causing an abnormal deformity.

Whi, Jung Hyun; Kim, Young Joo; Chun, Kyung Ah; Kim, Ki Tae; Chang, Eun Deok; Kim, Young Ok; Lee, Won [The Catholic University of Korea, Uijongbu (Korea, Republic of)

2007-06-15

260

Consideraciones actuales en hiperplasia fibrosa inflamatoria / Current considerations in inflammatory fibrous hyperplasia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish El objetivo de esta investigación es evaluar los aspectos clínicos, histológicos y las posibilidades de tratamiento de la hiperplasia fibrosa inflamatoria (HFI). Esta lesión se origina frecuentemente a partir de prótesis totales o parcial mal adaptadas, las cuales generan un traumatismo crónico de b [...] aja intensidad. Se han descrito lesiones en mandíbula y maxila, no existiendo predilección por ninguna de las arcadas dentales. Lesiones pequeñas pueden ser tratadas de manera conservadora, con remoción del agente causal o mediante atrofia por presión con nuevas prótesis, mientras que lesiones extensas y de larga evolución necesitarán de escisión quirúrgica. Si el tratamiento quirúrgico es considerado, éste debe incluir la remoción total de la lesión, usando diversas técnicas como bisturí “frío” (lámina), láser o electrocirugía.La remoción quirúrgica es necesaria, pues restaura el contorno normal del tejido y la adaptación protética. Algunos autores han reportado alteraciones displásicas en la HFI, pero la posibilidad de que ésta sufra una transformación maligna aún es muy discutida. Abstract in english The objective of this research is an evaluate of clinical and histologic aspects of fibrous inflammatory hyperplasia and the possibilities of its treatment. This lesion is frequently originated for using total or partial prosthesis which are inadequate adapted generating a chronic traumatism of low [...] intensity. Clinical cases in jaw and maxila have been reported, not existing predilection for any dental arches. Small lesions can be treated by the conservative way that means removing the causal agent or atrophying by putting pressure with a new prosthesis, whereas extensive lesions of large evolution need surgical excision. If the surgical treatment is considered, this should include the total removal of the lesion, using varieties of techniques such as “cold” scalpel, laser or electrosurgical techniques. The surgical removal is necessary because recover the normal contour of tissue and the prosthetic adaptation. reports exist about dysplasic alterations related to fibrous inflammatory hyperplasia, but the possibility of a malignant transformation is actually controversial.

Jose luis, Muñante-Cárdenas; Jaimes, Miguel; Olate, Sergio; José Ricardo, Albergaria-Barbosa.

2009-06-01

 
 
 
 
261

Fatty metamorphosis and other patterns in fibrous dysplasia  

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Full Text Available Abstract Background Interpretation of small biopsy fragments from suspected lesions of fibrous dysplasia with unusual clinical and / or radiological features may be challenging due to wide histomorphological spectrum of stromal appearances. Awareness of these variations should improve diagnostic confidence. Methods We retrospectively studied 26 cases of fibrous dysplasia (F- 19, M- 7; Ages ranged from 10 to 53 years with confirmed diagnosis. The sites of the lesions were skull bones (9, humerus (1, femur (8, tibia (2, fibula (3, talus (1, mandible (1, and maxilla (1. Results Different stromal patterns, variably admixed with the classical pattern, were observed in 58%(15/26 of the cases. 20%(3/15 of these had more than one pattern. Focal fatty metamorphosis as groups of fat cells in the central portion of the lesion in the stroma of fibrous dysplasia between osseous trabeculae was observed in 23%(6/26 cases. Other patterns included myxoid stroma in 16%(4/26, collagenization of stroma in 12%(3/26, stroma rich pattern (with paucity of trabeculae in 12%(3/26, foci of few foam cells in 23% (6/26, and calcified spherules in 12%(3/26. Focal osteoblastic rimming of trabeculae was observed only in 4%(1/26. Conclusions Various stromal variations and previously unreported fatty metamorphosis were frequently observed in fibrous dysplasia.

Komorowski Richard A

2003-08-01

262

Examination of compression and resilience characteristics of fibrous insulation blankets  

International Nuclear Information System (INIS)

Load-deflection characteristics of alumina and alumino-silicate fibrous blankets were experimentally determined. Load retention and springback capability of combinations of these materials were measured in a 10,000-hour test at surface temperatures of 650 to 10000C (1200 to 18320F). Experimental results are presented and future testing plans are discussed

263

Failure Regimes in (1+1)d in Fibrous Materials  

CERN Document Server

In this work, we introduce a model for fracture in fibrous materials which take into account the rupture height of the fibers, in contrast with previous models. Thus, we obtain the profile of the fracture and calculate its roughness, defined as the variance around the mean height. We investigate the relationship between the fracture roughness and the fracture toughness.

Menezes-Sobrinho, I L; Moreira, J G

2001-01-01

264

Chest wall reconstruction in a patient with sternal fibrous dysplasia.  

Science.gov (United States)

A patient with sternal fibrous dysplasia was treated via subtotal sternectomy using a sandwich titanium micromesh and polypropylene mesh to repair the chest wall defect. Pectoralis muscle flaps were created to cover the prosthesis. The patient had a normal postoperative course with good stability and postoperative cosmesis. PMID:21243578

Tang, J; Wang, J-J; Zhai, W; Zhang, S-C

2011-02-01

265

Mesenchymal chondrosarcoma arising in fibrous dysplasia of the femur.  

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The occurrence of mesenchymal chondrosarcoma in an area of fibrous dysplasia in the upper femur of a 28 year old man is reported. It is believed that this is the first documented example of such an association. A further unusual feature is the presence of benign giant cells in the mesenchymal chondrosarcomatous component.

Blackwell, J. B.

1993-01-01

266

[Giant retroperitoneal solitary fibrous tumor: report of a case].  

Science.gov (United States)

Giant solitary fibrous tumor (TFSG) is a spindle cell neoplasm, uncommon, being pleural a common site. We report a case of chronic presentation of 4 months duration with a palpable mass. We found, a tumor 35 x 20 x 15 cm .In the literature tumors diagnosed as TFSG are very rare, the first reported in our country. PMID:24108381

Gutiérrez Miranda, Luis Santiago; Grández-Urbina, José Antonio

2013-01-01

267

Subungual malignant melanoma  

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A rare case of subungual malignant melanoma in a 43-year-old male, with black dystrophic left middle finger nail plate with positive Hutchison sign is presented. Patient underwent disarticulation at the proximal interpholangeal joint. Histopathology confirmed malignant melanoma, and resection free of tumour cells.

De, Krishna K; Sharma P

2002-01-01

268

Malignent diseases in childhood  

International Nuclear Information System (INIS)

As malignant diseases in childhood are rare, and only a small group of radiotherapists have been able to gain experience in this field, this chapter treats the particularities of childhood from this aspect. The side effects of radiotherapy are particularly important here for the growing and developing organism of the child. The most frequently occuring malignant diseases are treated individually. (MG)

269

Direct Numerical Simulation of Liquid Transport Through Fibrous Porous Media  

Science.gov (United States)

Fluid flow through fibrous media occurs in many industrial processes, including, but not limited, to fuel cell technology, drug delivery patches, sanitary products, textile reinforcement, filtration, heat exchangers, and performance fabrics. Understanding the physical processes involved in fluid flow through fibrous media is essential for their characterization as well as for the optimization and development of new products. Macroscopic porous-media equations require constitutive relations, which account for the physical processes occurring at the micro-scale, to predict liquid transport at the macro-scale. In this study, micro-scale simulations were conducted using conventional computational fluid dynamics (CFD) technique (finite-volume method) to determine the macroscopic constitutive relations. The first part of this thesis deals with the single-phase flow in fibrous media, following which multi-phase flow through fibrous media was studied. Darcy permeability is an important parameter that characterizes creeping flow through a fibrous porous medium. It has a complex dependence on the medium's properties such as fibers' in-plane and through-plane orientation, diameter, aspect ratio, curvature, and porosity. A suite of 3D virtual fibrous structures with a wide range of geometric properties were constructed, and the permeability values of the structures were calculated by solving the 3D incompressible Navier-Stokes equations. The through-plane permeability was found to be a function of only the fiber diameter, the fibers' through-plane orientation, and the porosity of the medium. The numerical results were used to extend a permeability-porosity relation, developed in literature for 3D isotropic fibrous media, to a wide range of fibers' through-plane orientations. In applications where rate of capillary penetration is important, characterization of porous media usually involves determination of either the effective pore radius from capillary penetration experiments or a representative pore radius (R50) from pore-size distribution data. The relationship between effective and representative pore radii was studied by performing direct simulations of capillary penetration of a wetting liquid using a finite-volume-based volume-of-fluid (VOF) method. The simulated unidirectional liquid penetration through fibrous media followed Lucas-Washburn kinetics (L ˜ t1/2), except during the initial stages, which are dominated by inertial forces. Even though fluid properties and contact angle were kept constant in the simulations, the effective pore radii were found to be quite different from the representative radii. It can be concluded that the differences between effective and representative pore radii did not arise from contact angle variations. The unsaturated flow through fibrous media at the macro-scale is typically described using Richard's equation which requires constitutive relations: capillary pressure and permeability as a function of liquid saturation. In the present study, the quasi-static capillary pressure-saturation (P c-S) relationship for the primary drainage in a 3D isotropic fibrous medium was determined by performing micro-scale simulations using a VOF method. The Pc-S relationship obtained from the VOF method was compared with the results from the full-morphology (FM) method. Good agreement was observed between the results from the VOF and FM methods, thus suggesting that the FM method, a computationally less intensive method as compared to VOF method, may be sufficient for estimating the Pc-S relationship for primary drainage.

Palakurthi, Nikhil Kumar

270

Primary ovarian malignant melanoma  

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Full Text Available Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

Kostov Miloš

2010-01-01

271

Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma  

Science.gov (United States)

Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Childhood Alveolar Soft-part Sarcoma; Childhood Angiosarcoma; Childhood Epithelioid Sarcoma; Childhood Fibrosarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Mesenchymoma; Childhood Neurofibrosarcoma; Childhood Synovial Sarcoma; Dermatofibrosarcoma Protuberans; Metastatic Childhood Soft Tissue Sarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Stage I Adult Soft Tissue Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

2014-09-08

272

Malignant Proliferating Trichilemmal Tumor  

Science.gov (United States)

Proliferating trichilemmal tumor (PTT) is a benign tumor originating from the outer root sheath of a hair follicle. Malignant transformation in case of PTT is very rare and unusual finding. It is usually confused with squamous cell carcinoma both sharing many common features. So the identification of malignant PTT is very essential. Only 39 well-documented cases of malignant proliferating trichilemmal cyst have been published to date in the English language literature. We hereby present a case of a 75-year-old female patient with a rapidly growing swelling on the scalp. PMID:22470211

Goyal, Snigdha; Jain, Bhawna Bhutoria; Jana, Sritanu; Bhattacharya, Subodh K

2012-01-01

273

[Malignant tumours and physiotherapy].  

Science.gov (United States)

The analysis of the major studies on the treatment of malignant tumours with the application of physical factors has demonstrated that at present time no such factor can serve as an alternative to the standard combined treatment of malignant tumours, including surgery, radio- and chemotherapy. Certain physical factors can be used to improve the efficiency of conventional treatment, but large-scale well-planned randomized clinical trials are necessary to estimate and confirm their role in the treatment of cancer and other malignant tumours. PMID:23520931

Grushina, T I

2013-01-01

274

A case of dedifferentiated liposarcoma showing a biphasic pattern on 2-deoxy-2-F18- fluoro-D-glucose positron emission tomography/ computed tomography  

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Integrated 2-deoxy-2-F18-fluoro-D-glucose positron emission tomography combined with computed tomography (FDG-PET/CT) has been used in the field of soft tissue sarcoma. We report an 81-year-old man with dedifferentiated liposarcoma in the left thigh, which was composed of well-differentiated liposarcoma and pleomorphic malignant fibrous histiocytoma. As well as other radiological modalities, FDG-PET was able to demonstrate a biphasic signal pattern composed of well-differentiated liposarcoma ...

Kenichi Wakasa; Hiroaki Nakamura; Jun Takada; Naoto Oebisu; Manabu Hoshi

2013-01-01

275

Liposarcoma of the chest wall. Transformation of dedifferentiated liposarcoma from a recurrent lipoma.  

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Liposarcoma is the second most common soft tissue sarcoma after malignant fibrous histiocytoma in adults. It is frequently found in the extremities and retroperitoneum; rarely it can be seen in the chest wall. We report a rare case of giant liposarcoma originating from the chest wall representing a transformation of a relapsing lipoma in the same region. We performed chest wall resection, reconstruction with latissimus dorsi muscle transposition via posterola...

Pinar Bicakcioglu; Sak, Serpil D.; Tastepe, Abdullah I.

2012-01-01

276

Intraoperative radiotherapy (IORT) combined with external beam radiotherapy (EBRT) for soft-tissue sarcomas – a retrospective evaluation of the Homburg experience in the years 1995–2007  

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Abstract Purpose To retrospectively evaluate the results after a regimen of surgery, IORT (intraoperative radiotherapy), and EBRT (external beam radiotherapy) for soft-tissue sarcomas Methods 38 consecutive patients underwent IORT for soft-tissue sarcoma; 29 were treated for primary tumours, 9 for recurrences. There were 14 cases with liposarcomas, 8 with leiomyosarcomas, 7 with malignant fibrous histiocytomas. 27/38 tumours were located in the extremities, the ...

Bleuzen Caroline; Licht Norbert; Fleckenstein Jochen; Niewald Marcus; Ruebe Christian

2009-01-01

277

Enhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin  

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Photochemical internalisation (PCI) is a technique for releasing biologically active macromolecules from endocytic vesicles by light activation of a photosensitiser localised in the same vesicles of targeted cells. This study investigated the PCI of the toxin gelonin as a way of enhancing the effect of photodynamic therapy (PDT) on a human malignant fibrous histiocytoma transplanted into nude mice using the photosensitiser disulphonated aluminium phthalocyanine (AlPcS2a). Pharmacokinetic stud...

Dietze, A.; Peng, Q.; Selbo, P. K.; Kaalhus, O.; Mu?ller, C.; Bown, S.; Berg, K.

2005-01-01

278

The use of a modular titanium endoprosthesis in skeletal reconstructions after bone tumor resections: method presentation and analysis of 37 cases  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We analyzed 37 patients who underwent segmental wide resection of bone tumors and reconstruction with a modular titanium endoprosthesis at the Orthopaedic Oncology Group, between 1992 and 1998. Twelve patients were male and 25 were female, with a mean age of 30 years (9 - 81). The mean follow-up was 14 months (2 - 48). The diagnoses were: osteosarcoma (14 cases), metastatic carcinoma (10), Ewing's sarcoma (4), giant cell tumor (4), malignant fibrous histiocytoma (3), chondrosarcoma (1), and a...

Croci Alberto Tesconi; Camargo Olavo Pires de; Baptista André Mathias; Caiero Marcelo Tadeu

2000-01-01

279

Imaging malignant and apparent malignant transformation of benign gynaecological disease  

Energy Technology Data Exchange (ETDEWEB)

Common benign gynaecological diseases, such as leiomyoma, adenomyosis, endometriosis, and mature teratoma, rarely undergo malignant transformation. Benign transformations that may mimic malignancy include benign metastasizing leiomyoma, massive ovarian oedema, decidualization of endometrioma, and rupture of mature teratoma. The aim of this review is to provide a contemporary overview of imaging findings in malignant and apparent malignant transformation of benign gynaecological disease.

Lee, A.Y.; Poder, L.; Qayyum, A.; Wang, Z.J.; Yeh, B.M. [Department of Radiology, University of California San Francisco, San Francisco, CA (United States); Coakley, F.V., E-mail: Fergus.Coakley@radiology.ucsf.ed [Department of Radiology, University of California San Francisco, San Francisco, CA (United States)

2010-12-15

280

Radioimmunotherapy of malignant gliomas; Radioimmuntherapie maligner Gliome  

Energy Technology Data Exchange (ETDEWEB)

Despite all technical advances (intraoperative resection control, fluorescence guided resection, advances in external beam radiation techniques) and new consolidated findings on systemic chemotherapy treatment of malignant gliomas with conventional therapeutic modalities (surgery, radiation therapy and chemotherapy) is still highly unfavourable. Total tumor erradication is impossible due to tumor infiltrations into the normal brain and the limitations given by the limited tolerance of surrounding brain tissue. New treatment strategies, therefore, aim for a more selective destruction of tumor cells. Malignant glioma cells selectively express several antigens or receptors which are not or only to a minor extent present in normal brain tissue. Administration of radiolabelled monoclonal antibodies, especially when given locoregionally, targeting these tumor-specific antigens offers an innovative therapeutic strategy that has recently demonstrated encouraging antitumor effects and acceptable toxicity in many phase I/II clinical trials. This review offers a comprehensive summary of own experiences and results of clinical trials reported in the literature dealing with radioimmunotherapy of malignant glioma and highlights future plans to further develop this therapeutic strategy. (orig.)

Poepperl, G.; Tatsch, K. [Klinik und Poliklinik fuer Nuklearmedizin, Klinikum der Univ. Muenchen, Campus Grosshadern, Muenchen (Germany)

2008-06-15

 
 
 
 
281

Immunotherapy for Gastrointestinal Malignancies  

Directory of Open Access Journals (Sweden)

Full Text Available Gastrointestinal (GI malignancies (esophageal, gastric, pancreatic, intra- and extra-biliary ductal, hepatocellular, and colorectal cancers are an important cause of cancer incidence and mortality in the US and globally. GI cancers account for 15.4% and 23.8% of incident cancers and cancer-related deaths respectively in the US alone. Although earlier diagnosis and treatment advances have improved outcomes for some GI malignancies, the need for improved therapies in all disease phases (adjuvant, neoadjuvant and advanced is paramount. Utilization of monoclonal antibodies targeting against vascular endothelial growth factor (VEGF and epidermal growth factor receptor (EGFR has shown the success in selected colorectal carcinoma patients. More investigations of immunotherapy are on going in the treatment of GI malignances with different mechanisms and methods. In this article, we review data for established and evolving immunotherapy-related treatment options in GI malignancies.

Diwakar Davar

2014-05-01

282

Malignant primary pulmonary paraganglioma.  

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The histological, immunocytochemical, and electron microscopic findings in a case of malignant primary pulmonary paraganglioma are reported. The existence of this rare tumour is evidence for the presence of pulmonary chemoreceptors.

Hangartner, J. R.; Loosemore, T. M.; Burke, M.; Pepper, J. R.

1989-01-01

283

Temozolomide in malignant glioma  

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Gregor DresemannCenter for Neurooncology at Aerztehaus Velen, Velen, GermanyAbstract: Glioblastoma multiforme WHO grade IV (GBM) is the most aggressive ­malignant glioma and the most frequent primary tumor of the central nervous system. The median ­survival of newly diagnosed GBM patients was between 9 to 12 months prior to treatment with ­temozolomide being introduced. Primary resection that is as complete as possible is recommended for malignant glioma. Conventional ...

Gregor Dresemann

2010-01-01

284

Precursors to Lymphoproliferative Malignancies  

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We review monoclonal B-cell lymphocytosis (MBL) as a precursor to chronic lymphocytic leukemia and monoclonal gammopathy of undetermined significance (MGUS) as a precursor to plasma cell disorders. These conditions are present in the general population and increase with age. These precursors aggregate with lymphoproliferative malignancies in families suggesting shared inheritance. MBL and MGUS may share some of the same risk factors as their related malignancies but data are limited. While th...

Goldin, Lynn R.; Mcmaster, Mary L.; Caporaso, Neil E.

2013-01-01

285

Håndens maligne tumorer  

DEFF Research Database (Denmark)

Malignant tumours of the hand are rare and are often misdiagnosed. A painful swelling of the hand or digits are often diagnosed with an infection, benign tumours such as ganglion cysts, or arthritis. Wounds that do not heal despite adequate treatment should be biopsied to rule out malignancy. A correct diagnosis without delay is important because the life expectancy, due to a metastasis on the hand or fingers is approximately six months.

Knudsen, Britt Mejer; Rasmussen, Per Joen Svabo

2011-01-01

286

Disseminated malignant melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available A 25-year-old man had multiple asymptomatic, nodular lesions on the trunk, extremities and the face for 3 months. He also had left facial palsy with severe headache and vomiting. There were no other systemic or constitutional symptoms. Skin biopsy from a nodular lesion showed features of malignant melanoma, confirmed by Fontana Masson and S-100 protein staining. A diagnosis of disseminated malignant melanoma was made and the patient was treated symptomatically. The patient died in 4 months.

Verma Kaushal

1999-01-01

287

Disseminated malignant melanoma  

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A 25-year-old man had multiple asymptomatic, nodular lesions on the trunk, extremities and the face for 3 months. He also had left facial palsy with severe headache and vomiting. There were no other systemic or constitutional symptoms. Skin biopsy from a nodular lesion showed features of malignant melanoma, confirmed by Fontana Masson and S-100 protein staining. A diagnosis of disseminated malignant melanoma was made and the patient was treated symptomatically. The patient died in 4 months.

Verma Kaushal; Souza Paschal, D. X.; Sirka C; Raman R; Rathi Sanjay

1999-01-01

288

Hypercalcemia in malignancy.  

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The pathogenesis of hypercalcemia in malignancy has been enigmatic until recent years. Since the realization in 1980 that bioassays for parathyroid hormone detected a cross-reacting substance in malignancy, progress has been remarkably rapid. A parathyroid hormone-related protein was purified and identified by molecular cloning as a 141-amino acid peptide with limited homology to parathyroid hormone itself. Nonetheless, both peptides activate the parathyroid hormone receptor to produce hyperc...

Strewler, G. J.; Nissenson, R. A.

1990-01-01

289

Familial malignant retroperitoneal paraganglioma.  

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Paragangliomas are neuroendocrine tumours and those occurring in the head and neck have well recognized familial association. Retroperitoneal paragangliomas are uncommon and we present two cases of familial malignant retroperitoneal paraganglioma. Review of the literature revealed marked differences in the incidence and malignant potential of familial and non-familial paraganglioma. In contrast to the cases reported here, familial tumours are generally benign, though they may occur at multipl...

Sebastian, J. P.; Williams, S. E.; Wells, M.; Peake, M. D.

1989-01-01

290

Malignant chondroid syringoma  

Directory of Open Access Journals (Sweden)

Full Text Available An adult female presented with a painful recurrent swelling on the posterior aspect of the scalp of six months? duration, which was clinically diagnosed as fibroma. An excision biopsy showed anaplastic epithelial cells arranged in irregular cords and trabeculae, mitosis, malignant chondroid areas, desmoplasia and perineural invasion, suggesting malignancy. Wide excision of the tumor was the only treatment given since there was no metastasis.

Shashikala P

2004-05-01

291

[Malignancy-associated myositis].  

Science.gov (United States)

Inflammatory myopathies, also referred to as myositis, are a heterogeneous group of chronic inflammatory muscle diseases characterized by various clinical features and histological changes; in addition, patient with these disease exhibit positivity for autoantibodies as well as progressive inflammatory muscle damage and experienced weakness. Although it has been well known for a century that myositis, particularly dermatomyositis, can be associated with malignancy, it was not until recently that the result of robust epidemiological studies confirmed this association. Malignancy-associated myositis differs from primary myositis in many aspects. Prognosis and life expectancy for patients are determined on the basis of the underlying malignancy. Therefore, patient-specific examinations to detect an underlying cancer are important for the management of these patients. Recently, a novel myositis-specific autoantibody (anti-p155 or p155/p140 antibody) was identified in malignancy-associated myositis. The discovery of this autoantibody is important not only for an early diagnosis of adult-onset myositis patients with a higher risk of malignancy but also for a better understanding of the pathogenesis of paraneoplastic myositis. In addition, it has also been recently found that both regenerating cells in myositis muscles and several cancers known to be associated with myositis express high levels of myositis-specific autoantigens. Therefore, a model of paraneoplasia focusing on the expression of common autoantigens expression and immuno-targeting between cancer and muscle tissues in myositis has been proposed. In this review, we aim to describe epidemiological evidence for an association between myositis and malignancy, and to describe the clinical features of malignancy-associated myositis. We also aim to focus on a recently proposed model to understand the development of malignancy-associated myositis. PMID:20420184

Shimizu, Jun

2010-04-01

292

Gynecologic malignancies in adolescents.  

Science.gov (United States)

Gynecologic malignancies are rare in the pediatric and adolescent populations. Given the potential consequence of infertility and the negative impact on body image that can result from the treatment of these cancers, clinicians must be aware of the most current recommendations for medical and surgical therapy of gynecologic malignancies in these patients. This article focuses on the most common gynecologic cancers in pediatric and adolescent girls, with a special emphasis on treatment that maintain fertility and positive body image. PMID:15625993

Stepanian, Marshall; Cohn, David E

2004-10-01

293

[Malignant nail tumors].  

Science.gov (United States)

Because of the large number of different tissues making up the distal phalanx of fingers and toes, a large variety of malignant tumors can be found in and around the nail apparatus. Bowen disease is probably the most frequent nail malignancy. It is usually seen as a verrucous plaque of the nail fold and nail bed in persons above the age of 40 years. It slowly grows over a period of years or even decades before degenerating to an invasive squamous cell carcinoma. The latter may also occur primarily often as a weeping onycholysis. The next most frequent nail malignancy is ungual melanoma. Those arising from the matrix are usually pigmented and often start with a longitudinal melanonychia whereas those originating from the nail bed remain amelanotic, are often nodular and mistaken for an ingrown nail in an elderly person. The treatment of choice for in situ and early invasive subungual melanomas is generous extirpation of the nail apparatus whereas distal amputation is only indicated for advanced melanomas. In addition to these frequent nail malignancies, nail-specific carcinomas, malignant vascular and osseous tumors, other sarcomas, nail involvement in malignant systemic disorders and metastases may occur. In most cases, they cannot be diagnosed accurately on clinical grounds. Therefore, a high degree of suspicion is necessary in all isolated or single-digit proliferations that do not respond to conservative treatment. PMID:24718507

Haneke, E

2014-04-01

294

Radiotherapy of spontaneous fibrous connective-tissue sarcomas in animals.  

Science.gov (United States)

The clinical records and follow-up data obtained over 13 years on the results of radiotherapy of spontaneous fibrous connective-tissue sarcomas in dogs, cats, and horses were reviewed. The results obtained from the treatment of fibrosarcomas and sarcoids of horses indicated that radiation administered with 60Co is important in the medical and surgical management of these tumors. Fibrous connective-tissue sarcomas in horses were radioresponsive. When radiotherapy was applied postoperatively, the probability of a 2-year cure approached 50% for all prescribed radiation doses of less than 2,000 to greater than 4,000 rads. If radiation doses of 4,500-6,000 rads were used, a 2-year cure rate may approach or exceed 60%. PMID:1255767

Hilmas, D E; Gillette, E L

1976-02-01

295

Chemical and physicochemical characterization of agrowaste fibrous materials and residues.  

Science.gov (United States)

The objective of this study was to evaluate the chemical, physicochemical, and functional properties of agrowastes derived from okara ( Glycine max), corn cob ( Zea mays sp.), wheat straw ( Triticum sp.), and rice husk ( Oryza sativa) for potential applications in foods. The fibrous materials (FM) were treated with alkali to yield fibrous residues (FR). Rice husk contained the highest ash content (FM, 8.56%; FR, 9.04%) and lowest lightness in color (FM, 67.63; FR, 63.46), possibly due to the abundance of mineral constituents. Corn cob contained the highest amount of soluble dietary fiber (SDF), whereas okara had the highest total dietary fiber (TDF). The high dietary fiber fractions of corn cob and okara also contributed to the highest water- and oil-holding capacities, emulsifying activities, and emulsion stabilities for both FM and FR samples. These results indicate that these agrowastes could be utilized as functional ingredients in foods. PMID:18788708

Kuan, Yau-Hoong; Liong, Min-Tze

2008-10-01

296

Fibrous nanorod network of bismuth oxide by chemical method  

Energy Technology Data Exchange (ETDEWEB)

Fibrous nanorod network of monoclinic Bi{sub 2}O{sub 3} was grown onto amorphous glass substrates at room temperature using a simple and soft chemical method from aqueous bismuth nitrate solution. The fibrous network of nanorods was characterized by morphological, structural, optical and electrical properties. The nanorods were nearly uniform in dimensions, with diameter around 40 nm and length {approx}500 nm. The optical properties of the nanorods are studied in the UV-vis spectral range. The band gap calculated from the absorption spectrum is found to be 3.1 eV, indicating a considerable 'blue shift' relative to the bulk material. The dark electrical resistivity was measured as a function of temperature, which revealed the semiconducting nature with high electrical resistivity of the order of 10{sup 7} {omega} cm.

Gujar, T.P. [Thin Film Physics Laboratory, Department of Physics, Shivaji University, Kolhapur 416004, Maharashtra (India); Shinde, V.R. [Thin Film Physics Laboratory, Department of Physics, Shivaji University, Kolhapur 416004, Maharashtra (India); Lokhande, C.D. [Thin Film Physics Laboratory, Department of Physics, Shivaji University, Kolhapur 416004, Maharashtra (India); Han, Sung-Hwan [Department of Chemistry, Hanyang University, Sungdong-Ku, Haengdang-dong 17, Seoul 133-791 (Korea, Republic of)]. E-mail: shhan@hanynag.ac.kr

2006-08-25

297

Fibrous nanorod network of bismuth oxide by chemical method  

International Nuclear Information System (INIS)

Fibrous nanorod network of monoclinic Bi2O3 was grown onto amorphous glass substrates at room temperature using a simple and soft chemical method from aqueous bismuth nitrate solution. The fibrous network of nanorods was characterized by morphological, structural, optical and electrical properties. The nanorods were nearly uniform in dimensions, with diameter around 40 nm and length ?500 nm. The optical properties of the nanorods are studied in the UV-vis spectral range. The band gap calculated from the absorption spectrum is found to be 3.1 eV, indicating a considerable 'blue shift' relative to the bulk material. The dark electrical resistivity was measured as a function of temperature, which revealed the semiconducting nature with high electrical resistivity of the order of 107 ? cm

298

Medical image of the week: solitary fibrous tumor  

Directory of Open Access Journals (Sweden)

Full Text Available A 68 year old female with a history of resected lung cancer and new onset joint pain and swelling presented for evaluation. Imaging revealed a right intrapleural mass and resection confirmed solitary fibrous tumor (SFT of the pleura (benign. The patient experienced resolution of her joint pain, which was due to pulmonary hypertrophic osteoarthropathy, shortly after resection. Although not present in our patient, tumor induced hypoglycemia (Doege-Potter syndrome can also be seen in SFTs. Solitary fibrous tumors are uncommon neoplasms of mesenchymal tissue, and can originate from either visceral or parietal pleural surfaces. Though they can grow to large size before clinical detection, the majority are benign, and can be treated with en bloc surgical resection.

Baumann J

2013-09-01

299

Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Solitary fibrous tumors (SFT represent a rare entity of soft tissue tumors. Previously considered being of serosal origin and solely limited to the pleural cavity the tumor has been described in other locations, most particularly the head and neck. Extrathoracic SFT in the soft tissues of the trunk and the extremities are very rare. Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and treatment results. Methods Data were obtained from patients' records, phone calls to the patients' general practitioners, and clinical follow-up examination, including chest X-ray, abdominal ultrasound, and MRI or computed tomography. Results There were 6 females and 3 males, whose age at time of diagnosis ranged from 32 to 92 years (mean: 62.2 years. The documented tumors' size was 4.5 to 10 cm (mean: 7 cm. All tumors were located in deep soft tissues, 3 of them epifascial, 2 subfascial, 4 intramuscular. Four tumors were found at the extremities, one each at the flank, in the neck, at the shoulder, in the gluteal region, and in the deep groin. Two out of 9 cases were diagnosed as atypical or malignant variant of ESFT. Complete resection was performed in all cases. Follow-up time ranged from 1 to 71 months. One of the above.mentioned patients with atypical ESFT suffered from local relapse and metastatic disease; the remaining 8 patients were free of disease. Conclusion ESFT usually behave as benign soft tissue tumors, although malignant variants with more aggressive local behaviour (local relapse and metastasis may occur. The risk of local recurrence and metastasis correlates to tumor size and histological status of surgical resection margins and may reach up to 10% even in so-called "benign" tumors. Tumor specimens should be evaluated by experienced soft tissue pathologists. The treatment of choice is complete resection followed by extended follow-up surveillance.

Steinau Hans-Ulrich

2006-07-01

300

Enzyme histochemical study on bone tumors.  

Directory of Open Access Journals (Sweden)

Full Text Available A total of 19 cases with bone tumors, including six osteosarcomas. three giant cell tumors of bone, one malignant fibrous histiocytoma, four nonossifying fibromas, four chondromas and one chondrosarcoma, were examined as to enzyme histochemistry; the enzymes consisted of alkaline phosphatase (ALPase, acid phosphatase (ACPase, nonspecific esterase (NSE, adenosine triphosphatase (ATPase, 5'-nucleotidase (5'-Nucl and beta-glucuronidase (beta-Gl. Osteosarcoma was strongly positive for ALPase followed by 5'-Nucl. Giant cell tumor, malignant fibrous histiocytoma and nonossifying fibroma showed enzyme histochemistry similar to each other: multinucleated giant cells and round cells in these tumors were strongly positive for ACPase, NSE, ATPase and 5'-Nucl simulating osteoclasts and histiocytes, whereas spindle cells were positive for ATPase and 5'-Nucl in their cytoplasm and weakly positive for ACPase. Chondroma and chondrosarcoma were focally positive for ACPase and NSE; the ACPase was sensitive to tartaric acid treatment. These observations showed that ALPase activity is very characteristic to osteosarcoma, and is useful for its diagnosis. From enzyme histochemistry, giant cell tumor, malignant fibrous histiocytoma and nonossifying fibroma can be regarded as a histiocyte-derived tumor of bone in contrast to osteosarcoma and cartilaginous tumors.

Yoshida,Haruhiko

1982-12-01

 
 
 
 
301

Surgical treatment of fibrous dysplasia in the proximal femur  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The aim of this study was to summarize oncological and functional results and to investigate surgical treatment methods and efficacies by conducting a retrospective study of patients with fibrous dysplasia (FD) in the proximal femur. A total of 15 patients with FD in the proximal femur were selected. Among them, 12 cases were monostotic and 3 cases were polyostotic. In addition, 2 cases were accompanied by shepherd’s crook deformity. All cases received internal fixation following focus cure...

Tong, Zhichao; Zhang, Wentao; Jiao, Ning; Wang, Kunzheng; Chen, Bo; Yang, Tuanmin

2013-01-01

302

Oral Calcifying Fibrous Pseudotumor: Case Analysis and Review  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Calcifying fibrous pseudotumor (CFT) is a rare distinct soft-tissue lesion characterized histologically by lymphoplasmacytic aggregates in a rich collagenized background with abundant psammomatous and dystrophic calcifications. Occurring most often in children and young adults, CFTs are clinically benign lesions that can form over a broad anatomic distribution, including in subcutaneous and deep soft tissues, as well as in serosal and visceral locations. The cause and mechanisms of pathogenes...

Bell, Diana M.; Dekmezian, Roupen H.; Husain, Shaista A.; Luna, Mario A.

2008-01-01

303

Imaging findings of calcifying fibrous tumour of the liver  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Calcifying fibrous tumour (CFT) is a recently recognised rare benign lesion characterised by dense hyalinised collagenous tissue, psammomatous or dystrophic calcifications and a lymphoplasmacytic infiltrate. The usual locations of the lesion are the soft tissues of the extremities, but rarely it occurs in the abdomen. Recently, we experienced a case of CFT found in the liver of a 29-year-old woman. Here, we describe the characteristic radiological and histopathological findings, along with a ...

Jo, B-j; Yoon, S-w; Ahn, H. J.; Kwon, S. W.

2011-01-01

304

Gastric calcifying fibrous tumor removed by endoscopic submucosal dissection  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The World Health Organization describes calcifying fibrous tumors (CFTs) as rare, benign lesions characterized by hypocellular, densely hyalinized collagenization with lymphoplasmacytic infiltration. These tumors rarely involve the gastrointestinal (GI) tract. A routine endoscopic upper gastrointestinal screen detected a 10-mm submucosal tumor (SMT) in the lesser curvature of the lower corpus of the stomach of an apparently healthy, 37-year-old woman with no history of Helicobacter pylori inf...

Naotaka Ogasawara; Shinya Izawa; Mari Mizuno; Atsushi Tanabe; Tomonori Ozeki; Hisatsugu Noda; Emiko Takahashi; Makoto Sasaki; Toyoharu Yokoi; Kunio Kasugai

2013-01-01

305

Clinicoradiologic perspective of a severe case of polyostotic fibrous dysplasia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fibrous dysplasia (FD) of bone is a congenital non-heritable disorder that was first reliably reported by von Recklinghausen, when he described patients with pathologic condition of bone characterized by deformity and fibrotic changes that he termed as osteitis fibrosa generalisata. FD may involve one bone (monostotic) or multiple bones (polyostotic) and occurs throughout the skeleton with predilection for long bones, ribs, and cranio-facial bones. Seventy percent of the lesions are monostoti...

Sandhu, Simarpreet V.; Sandhu, Jagpreet Singh; Sabharwal, Amarpreet

2012-01-01

306

Characterization of the thermal conductivity for fibrous refractory composite insulations  

Science.gov (United States)

Thermal conductivity for a family of fibrous, refractory composite insulations are characterized through the use of an engineering model and arc-jet data. The model defines the composite as a uniform pore material using measured physical and mechanical properties. Efficiency parameters assigned to the solid and radiation conduction terms in the thermal conductivity equation were found to be dependent only on solid volume fraction and porosity.

Stewart, D. A.; Leiser, D. B.

1985-01-01

307

Engineering of Fibrous Scaffolds for use in Regenerative Medicine  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Tissue engineering with fibrous scaffolds is emerging as a major research area in the field of regenerative medicine. The major themes pursued in this thesis are the study of the cellular response to nanofibrous constructs, the role of nanofibres in the engineering of synthetic scaffolds, and the development of technology to facilitate the fabrication of nanofibrous scaffolds with controlled architectures. Cells cultured on multi?walled carbon nanotubes displayed reduced prol...

George, Julian H. S.

2009-01-01

308

Radiologic Features of Fibrous Hamartoma of Infancy Involving the Buttocks  

International Nuclear Information System (INIS)

Fibrous hamartoma of infancy (FHI) is a rare benign subcutaneous tumor that presents in children younger than two years. The tumor mostly affects the trunk, axilla and upper extremities. Imaging findings of FHI that involve the buttocks have not been reported in the clinical literature. We reported the imaging features of a lesion in a 9-month-old infant who presented with a palpable mass on the buttocks. The imaging findings were evaluated after a review of previous studies

309

Focal Electroencephalography Rhythm Asymmetry due to Focal Skull Fibrous Dysplasia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

An unusual pervasive and persistent asymmetry in background rhythm was found on surface electroencephalography (EEG) recordings in a 22 year old with new onset of generalized seizure activity. Radiographic correlation with computed tomography, positron emission tomography and bone scan imaging uncovered that the higher amplitude left frontal-parietal background activity was related to a circumscribed area of left frontal-parietal fibrous dysplasia affecting the skull. This case report emphasi...

Meyer, Michael A.

2014-01-01

310

High strength and ductile fibrous concrete of enhanced fire resistance  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In the present work a Fiber Reinforced Concrete of Enhanced Fire Resistance (FRCEFR) was developed and its properties are characterized by experimental research. This concrete is intended to have enough resistance for the most structural engineering applications and is reinforced with a fibrous system to assure the necessary ductility and to improve its fire resistance. Two types of fibers are used to accomplish the aforementioned requisites for the concrete. The research perfo...

Lourenc?o, Lu?cio; Barros, Joaquim A. O.; Santos, S. P. F.

2007-01-01

311

Determination of physical properties of fibrous thermal insulation  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET) with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool) are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a de...

Jeandel G.; Monod B.; Lassue S.; Joulin A.; Tilioua A.; Libessart L.

2012-01-01

312

Management of malignant pleural effusions.  

LENUS (Irish Health Repository)

Malignant pleural effusions are a common clinical problem in patients with primary thoracic malignancy and metastatic malignancy to the thorax. Symptoms can be debilitating and can impair tolerance of anticancer therapy. This article presents a comprehensive review of pharmaceutical and nonpharmaceutical approaches to the management of malignant pleural effusion, and a novel algorithm for management based on patients\\' performance status.

Uzbeck, Mateen H

2010-06-01

313

Solitary fibrous tumor of the thigh with epithelioid features: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Extrapleural Solitary Fibrous tumors (SFTs have been increasingly reported. The retroperitoneum, deep soft tissues of proximal extremities, abdominal cavity, trunk, head and neck are the most common extraserosal locations reported. Microscopically they show a wide range of morphological features, and so the differential diagnosis is extensive. Immunohistochemically, they commonly express CD34, vimentin, bcl-2 and CD99. Epithelial membrane antigen (EMA and smooth muscle actin (SMA may occasionally be expressed. Epithelioid morphology in extrapleural SFT has only very occasionally been described (five cases reported, some of them with biphasic pattern and others with malignant characteristics. Case presentation A SFT of the thigh with epithelioid areas in a 63 year old woman is reported. Microscopically the tumor showed areas hypo and hipercellular. At the periphery of the hipercellular areas there were nodules composed of epithelioid cells. Immunohistochemically both the spindle and epithelioid cells were positive for CD34, vimentin, bcl-2 and CD99. Epithelial, neural and muscular markers were negative. Molecular study was done and ruled out a synovial sarcoma. Conclusion Ten cases of SFT of the thigh have been reported but to our knowledge this is the first case with epithelioid morphology affecting the extremities. Identification of this pattern of SFT is of importance, to avoid misdiagnosis with other more aggressive conditions in soft tissue.

Garcia-Garcia Jose

2007-06-01

314

Erosive separation of organic coatings from fibrous substrates.  

Science.gov (United States)

The separation of organic coatings from fibrous substrates is a key problem in recycling processes. This problem applies to carpets, technical textiles and automotive interior components. This paper reports about results of laboratory studies involving the application of high-speed liquid jets to solve this problem. Results from high-speed video images are used to qualify the principal erosion process. It is shown that the coating material is first ground by the jet; the generated erosion debris is then pushed through the permeable fibrous fabric of the substrate. It is also found that threshold conditions exist for the coating grinding process and for the debris transportation. These threshold conditions depend on target composition and process parameters. A phenomenological separation model is introduced. The influence of key process parameters, namely jet velocity, exposure time, stand-off distance and impact angle, is also investigated. It is found that high-speed liquid jets are suitable tools for separating organic coatings completely and selectively from fibrous substrates. Recommendations on how to optimise the erosion process are derived from the results. PMID:15474739

Weiss, M; Momber, A W

2004-11-01

315

Geometric characterization and simulation of planar layered elastomeric fibrous biomaterials.  

Science.gov (United States)

Many important biomaterials are composed of multiple layers of networked fibers. While there is a growing interest in modeling and simulation of the mechanical response of these biomaterials, a theoretical foundation for such simulations has yet to be firmly established. Moreover, correctly identifying and matching key geometric features is a critically important first step for performing reliable mechanical simulations. The present work addresses these issues in two ways. First, using methods of geometric probability, we develop theoretical estimates for the mean linear and areal fiber intersection densities for 2-D fibrous networks. These densities are expressed in terms of the fiber density and the orientation distribution function, both of which are relatively easy-to-measure properties. Secondly, we develop a random walk algorithm for geometric simulation of 2-D fibrous networks which can accurately reproduce the prescribed fiber density and orientation distribution function. Furthermore, the linear and areal fiber intersection densities obtained with the algorithm are in agreement with the theoretical estimates. Both theoretical and computational results are compared with those obtained by post-processing of scanning electron microscope images of actual scaffolds. These comparisons reveal difficulties inherent to resolving fine details of multilayered fibrous networks. The methods provided herein can provide a rational means to define and generate key geometric features from experimentally measured or prescribed scaffold structural data. PMID:25311685

Carleton, James B; D'Amore, Antonio; Feaver, Kristen R; Rodin, Gregory J; Sacks, Michael S

2015-01-15

316

Analysis of effective thermal conductivity of fibrous materials  

Science.gov (United States)

The objective of this research is to gain a better understanding of the various mechanisms of heat transfer through fibrous materials and to gain insight into how fill-gas pressure influences the effective thermal conductivity. By way of first principles and some empiricism, two mathematical models are constructed to correlate experimental data. The data are obtained from a test series measuring the effective thermal conductivity of Nomex using a two-sided guarded hot-plate heater apparatus. Tests are conducted for certain mean temperatures and fill-gases over a range of pressures varying from vacuum to atmospheric conditions. The models are then evaluated to determine their effectiveness in representing the effective thermal conductivity of a fibrous material. The models presented herein predict the effective thermal conductivity of Nomex extremely well. Since the influence of gas conduction is determined to be the most influential component in predicting the effective thermal conductivity of a fibrous material, an improved representation of gas conduction is developed. Finally, some recommendations for extension to other random-oriented fiber materials are made concerning the usefulness of each model depending on their advantages and disadvantages.

Futschik, Michael W.; Witte, Larry C.

1993-01-01

317

Undetermined fibrous tumor with calcification in the cerebellopontine angle.  

Science.gov (United States)

In this report, we introduce an undetermined fibrous tumor with calcification occurring in the cerebellopontine angle (CPA). A 51-year-old woman was admitted with a short history of dizziness. Computed tomography and magnetic resonance images revealed a 2×2×2 cm sized mass at the left CPA which was round and calcified. There was no dura or internal auditory canal involvement. At surgery, the tumor was located at the exit of 7th and 8th cranial nerve complex. It was very firm, bright yellow and well encapsulated. Histologic findings revealed that the tumor was predominantly composed of fibrous component, scant spindle cells and dystrophic calcification. Immunohistochemical staining demonstrated positive for vimentin and negative for epithelial membrane antigen (EMA), S-100 protein, CD34, factor XIIIa and smooth muscle actin. The diagnosis was not compatible with meningioma, schwannoma, metastatic brain tumors, and other fibrous tumors. Although the tumor was resected in total, long term follow-up monitoring is necessary due to the possibility of recurrence. PMID:20856670

Cheon, Se Hun; Kang, Shin-Hyuk; Park, Kyung Jae; Chung, Yong Gu

2010-08-01

318

Aggressive malignant abdominal mesothelioma: Clinical report  

International Nuclear Information System (INIS)

A 32-year-old Filipino female, working as an x-ray technician, presented to the Emergency Room (ER) with acute abdominal pain for one day. The pain was mainly on the left side and left hypochondrium. She had recurring abdominal pain before but not significant to worry her. She also complained of abdominal distension, which she noticed one week ago. Abdominal examination revealed fullness in the left hypochondrium with marked tenderness but negative rebound. Abdominal ultrasound (US) showed a huge mass mainly in the left hypochondrium. The origin of the mass cannot be identified by US. A computerized tomography scan showed a mass in the left side of the abdomen crossing the midline with a necrotic centre. The hospital course of the patient runs smoothly, and she was discharged after 7-days and referred to an Oncology Center. Abdominal mesothelioma is a neoplasm arising from the mesothelial surface lining the abdominal cavity. It is less frequent than that of the pleura. It is a rapidly growing and fatal malignancy with a median survival of less than 1-year. The relation between pleural malignant mesothelioma and asbestos is well recognized since it was described in 19602 but implication of asbestos exposure in the etiology of the peritoneal type is less obvious. This patient history is giving no obvious exposure to asbestos but as she is working in the Radiology Department as an x-ray technician she is well exposed to x-ray, but the effect of radioactivity on inductiont the effect of radioactivity on induction of mesothelioma is still disputed.4 There are several reports linking malignant mesothelioma to radioactivity due to radiation therapy.The fibrous mesothelioma (sarcomatous), as in this case, which is difficult to diagnose microscopically, looks like a fibroma, unless helped by tissue culture. The treatment options of malignant mesothelioma include surgery, intraperitoneal chemotherapy and whole abdominal radiation or multimodality therapy, which were suggested that might prolong the survival in patients with peritoneal mesothelioma.5 Although peritoneal mesothelioma is rare, progress in its management has occurred, survival has been extended and selection factors by which patients may be allocated to aggressive management strategies have been defined

319

MALIGNANT SALIVARY GLAND TUMORS  

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Full Text Available Malignant salivary gland tumors make up 6% of all head and neck tumors. Several types of cancer can develop in these glands. Only malignant tumors of the salivary glands are discussed in this paper. The diagnosis and treatment of salivary gland malignancies remain complex, with challenging problems for maxillo-facial surgeon. Scientists have found few risk factors that make a person more likely to develop salivary gland cancer. Salivary gland cancer is uncommon, and there is no widely recommended screening schedule for this cancer. CT scanning or MRI is useful for determining the extent of large tumors, for evaluating extraglandular extension, for determining the actual depth of parotid tumors, and for discovering other tumors in one gland or in the controlateral gland. Fine-needle aspiration biopsy (FNAB is a valuable diagnostic adjunct in evaluation of head and neck masses but its role in evaluation of salivary gland tumors is controversial. There are also discussed some histologic findings about mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, carcinoma ex-pleomorphic adenoma, squamous cell carcinoma and adenocarcinoma developed in salivary glands. Carefully planned and executed surgical excision is the primary treatment for all malignant tumors of the salivary glands. The principles of surgery vary with the site of origin. The extent of surgery is based on the size of the tumor, local extension and neck metastases. Staging of malignant salivary gland tumors is important for predicting prognosis and for accurate comparison of treatment results.

Violeta Trandafir

2010-05-01

320

Malignant epithelial odontogenic tumors.  

Science.gov (United States)

Malignant epithelial odontogenic tumors are very rare. They may arise from the epithelial components of the odontogenic apparatus. The rests of Malassez, the reduced enamel epithelium surrounding the crown of an impacted tooth, the rests of Serres in the gingiva, and the linings of odontogenic cysts represent the precursor cells for malignant transformation. Because metastatic carcinoma is the most common malignancy of the jaws, the diagnosis of a primary intraosseous carcinoma must always be made to the exclusion of metastatic disease. Odontogenic carcinomas include malignant (metastasizing) ameloblastoma, ameloblastic carcinoma, primary intraosseous squamous cell carcinoma, clear cell odontogenic carcinoma, and malignant epithelial ghost cell tumor. There are specific histopathologic features that support the diagnosis of a primary carcinoma of odontogenic epithelium which are presented in this article. Immunohistochemical (IHC) staining is important for distinguishing clear cell odontogenic carcinoma from metastatic renal cell tumors, yet IHC stains are not particularly helpful for other lesions in this group-all of which exhibit low molecular weight cytokeratin positivity. Aggressive growth and nodal and distant metastases occur with all of these entities. PMID:10587275

Eversole, L R

1999-11-01

 
 
 
 
321

PET in uterine malignancies  

Directory of Open Access Journals (Sweden)

Full Text Available Positron Emission Tomography (PET or integrated PET/Computed Tomography (PET/CT with 18F-Fluoro-Deoxy-Glucose (18F-FDG is a functional imaging modality, useful in the characterization of undetermined morphological findings, and in the staging/re-staging of a large number of malignancies. Although its use in uterine malignancies has been poorly investigated, in recent years the employment of this technique has constantly increased. In this review, we evaluate the role of PET (/CT with 18FFDG in uterine malignancies (cervical and endometrial cancers as well as uterine sarcomas, underlying its advantages and discussing its limitations. Metabolic and anatomic information given by PET/CT with 18F-FDG could be useful in the evaluation of local and distant disease involvement at the staging, in the detection of disease recurrence, and in the evaluation of the response after chemotherapy and/or radio-therapy.

Valeria Pirro

2010-07-01

322

Malignant spindle cell tumor arising in the mandible of a patient with florid osseous dysplasia.  

Science.gov (United States)

Florid osseous dysplasia is a non-neoplastic condition of the alveolar processes of the jaws characterized by the replacement of multiple foci of bone by fibrous connective tissue, accompanied by gradual deposition of cementum, bone, or both. The lesions are not associated with inflammatory diseases of the dental pulp or periodontal tissues. In fully developed florid osseous dysplasia, there are multiple lobulated masses in the alveolar bone bilaterally in the mandible and sometimes in the maxilla. This is the first report of a malignancy originating within the jaws of a patient with florid osseous dysplasia. A spindle cell malignancy was diagnosed in the mandible of a 54-year-old black woman whose jaw was affected by florid osseous dysplasia bilaterally. Despite extensive surgery and radiotherapy, the patient died 20 months after diagnosis of the malignancy. PMID:10442947

Schneider, L C; Dolinsky, H B; Grodjesk, J E; Mesa, M L; Doyle, J L

1999-07-01

323

A 40-year-old gossypiboma (foreign body granuloma) mimicking a malignant femoral surface tumor  

Energy Technology Data Exchange (ETDEWEB)

The patient was a 61-year-old man who developed gossypiboma of the left thigh and femur resulting in the imaging appearances of a malignant surface tumor. He had a past history of surgery on the left femur for open fracture 40 years previously. Radiographs and CT showed a soft tissue mass with osteolysis and periosteal thickening of the left femur. On MRI, the mass showed heterogeneous signal intensity with contrast enhancement at the periphery, suggesting a malignancy. {sup 99m}Tc-HMDP bone scintigraphy showed a faint ring-like uptake, but thallium -201 scintigraphy did not show any uptake in the tumor. An extensive intralesional excision was performed. Postoperative histopathological examination showed a fibrous foreign body with reactive changes. There were neither viable cells nor atypical giant cells around the foreign body. No malignant change was evident. Based on surgical and histopathological examinations, the tumor was finally diagnosed as gossypiboma related to a retained surgical sponge. (orig.)

Sakayama, Kenshi; Fujibuchi, Taketsugu; Kidani, Teruki; Miyawaki, Joji; Yamamoto, Haruyasu [Ehime University School of Medicine, Department of Orthopaedic Surgery, Ehime (Japan); Sugawara, Yoshifumi [Ehime University School of Medicine, Department of Radiology, Ehime (Japan)

2005-04-01

324

Paraspinal tuberculosis mimicking malignancy  

Directory of Open Access Journals (Sweden)

Full Text Available Tuberculosis (TB of the paraspinal muscles is a rare clinical entity. We present a case of an 18-year-old, Saudi male patient that presented with the clinical picture of a paraspinal mass that turned out to be paraspinal TB. It originated from the paraspinal tissues and muscles, and invaded the C6 and C7 vertebrae. Initially, it was highly suspicious for malignancy. A biopsy confirmed the diagnosis of TB and the patient was treated successfully with anti-TB therapy. It is important to be aware that paraspinal tuberculosis can mimic malignancy

Ameen Z. Alherabi

2013-12-01

325

Malignant system diseases  

International Nuclear Information System (INIS)

Following a brief survey on the not entirely clear aetiology of the malignant system diseases, their epidemiology and histology, as well as the clinic and treatment fundamentals. The author deals with malignant lymphoma and the myeloproliferative diseases in two special sections. In the case of lymphoma he distinguishes between the treatment of Hodgkin lymphoma and non-Hodgkin lymphoma and gives a survey on the histology, various stages, performance of radiotherapy with therapy plan, as well as prognoses and results. The myeloproliferative diseases are treated according to their individual forms (acute, chronic, myeloic leukemia and chronic lymphatic leukemia, osteomyelosklerosis, polycythaemic vera, plasmocytoma and eosinophile granulom) and the corresponding form of radiotherapy. (MG)

326

Recurrent malignant gliomas.  

Science.gov (United States)

In almost all patients, malignant glioma recurs following initial treatment with maximal safe resection, conformal radiotherapy, and temozolomide. This review describes the many options for treatment of recurrent malignant gliomas, including reoperation, alternating electric field therapy, chemotherapy, stereotactic radiotherapy or radiosurgery, or some combination of these modalities, presenting the evidence for each approach. No standard of care has been established, though the antiangiogenic agent, bevacizumab; stereotactic radiotherapy or radiosurgery; and, perhaps, combined treatment with these 2 modalities appear to offer modest benefits over other approaches. Clearly, randomized trials of these options would be advantageous, and novel, more efficacious approaches are urgently needed. PMID:25219814

Kirkpatrick, John P; Sampson, John H

2014-10-01

327

Malignant pleural mesothelioma  

International Nuclear Information System (INIS)

In 34 patients with suspected malignant pleural mesothelioma the results of computed tomography are compared with the findings of 67Ga-scintigraphy. The differential diagnosis of 14 pleural mesotheliomas, 7 pleural carcinoses, 10 inflammatory and 3 other pleural diseases is performed more accurately by CT than by scintigraphy. 67Ga uptake depends on the thickness of inflammatory as well as malignant lesions. Thus, numerous pleural processes that can be localised by CT escape scintigraphic detection, CT is indicated if there is clinical and radiological suspicion of pleural mesothelioma; in that case, there is hardly any indication for 67Ga scintigraphy. (orig.)

328

Optimization of Grafted Fibrous Polymer as a Solid Basic Catalyst for Biodiesel Fuel Production  

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Grafted fibrous polymer with quaternary amine groups could function as a highly-efficient catalyst for biodiesel fuel (BDF) production. In this study, the optimization of grafted fibrous polymer (catalyst) and transesterification conditions for the effective BDF production was attempted through a batch-wise transesterification of triglyceride (TG) with ethanol (EtOH) in the presence of a cosolvent. Trimethylamine was the optimal quaternary amine group for the grafted fibrous catalyst. The opt...

Yuji Ueki; Seiichi Saiki; Takuya Shibata; Hiroyuki Hoshina; Noboru Kasai; Noriaki Seko

2014-01-01

329

Experimental characterization and modeling of the permeability of fibrous preforms using gas for direct processes application.  

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A methodology to measure in-plane permeability of fibrous media using a transient one dimensional air flow is developed. The method, based on the measurement of gas pressure at the boundaries throughout the transient flow, is convenient, clean and fast, avoids usage of a gas flow meter and offers a way to study the gas transport within fibrous media. The gas transport through fibrous porous media is described by several models to comply with different flow regimes. The permeability, only depe...

Hou, Yi

2012-01-01

330

Design of sintered, tough, oxide laminate and fibrous monolithic composites  

Science.gov (United States)

Tough, oxide, laminated and fibrous monolithic composites were fabricated by using tape casting and co-extrusion technique, respectively. Mullite (3Al 2O3·2SiO2), alumina (Al2O 3), 50 vol% alumina · 50 vol% YAG (yttrium aluminum garnet, Y 3Al5O12) in situ composite, 50 vol% alumina · 50 vol% mullite in situ composite, zirconia (ZrO 2), and nickel aluminate (NiAl2O4) were used as matrix materials. Aluminum phosphate (AlPO4), alumina platelets, and 50 vol% alumina · 50 vol% leucite (KAlSi2O6) were chosen as high temperature applicable interphase materials. ICP (Inductively coupled plasma) data indicated no extensive decomposition of AlPO4 heat treated at 1600 and 1800°C. The AlPO4 worked as a stable, porous, weak, crack deflecting interphase material with three point bending strength of 1.5 MPa and 61% of theoretical density after heat treatment at 1600°C for 10h. The 50 vol% alumina · 50 vol% YAG in situ composite had a bending strength of 361 MPa after sintering at the condition of 1700°C/5h. A : B (C) : D (E) bimodal designs were proposed to increase the toughness of the laminated composites. 1 : 5 (6) : 12 (1) bimodal laminated composite had a bending strength and a work of fracture of 142 MPa and 0.51 KJ/m2, respectively. Fibrous monolithic composites with different interphase thickness and interphase composition were fabricated. 2-, 3- and mixed-layer fibrous monolithic composites were made.

Kim, Dong-Kyu

331

Does the pleomorphic xanthoastrocytoma exist? Problems in the application of immunological techniques to the classification of brain tumors.  

Science.gov (United States)

A case of a fibrous xanthomatous tumor of the meninges is reported. This is a rare tumor of childhood in which the characteristic pleomorphic histology contrasts with the good clinical prognosis. These tumors were reclassified as pleomorphic xanthoastrocytomas (PXA) due to their glial fibrillary acidic protein (GFAP) positivity. In the present tumor, GFAP was absent from nearly all cell bodies in most of the leptomeningeal regions of the tumor but could be detected with greater frequency at the cortical-leptomeningeal border zones and in the areas in which the tumor had infiltrated the cortex. All the tumor cells expressed vimentin and in, addition, most expressed alpha-1-antitrypsin, alpha-1-antichymotrypsin, tartrate-resistant acid phosphatase, common leukocyte antigen, and OKM1. This spectrum of marker staining corresponded not only to the pattern observed in two cutaneous fibrous histiocytomas and one malignant fibrous histiocytoma, but also to the results previously published in the literature with regard to fibrohistiocytic tumors. By contrast, this spectrum of monocytic-histiocytic marker staining was not seen in gliomas. We, therefore, regard the PXA as a mesenchymal tumor of the meninges, identical to benign fibrous histiocytomas elsewhere in the body. The possible reasons why this mesenchymal tumor can show GFAP positivity in the leptomeningeal border zone are discussed. PMID:3213427

Paulus, W; Peiffer, J

1988-01-01

332

A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots  

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The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus). From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-?-D-glucopyranoside) and three known glycosides [1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (liriopeoside A), 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyran...

Yong Yan Wang; Zhi Wei Deng; Zhi Long Liu; Shu Shan Du; Peng Liu; Chun Qi Bai; Qi Zhi Liu; Zi Mu Liu; Gang Li Wang; Hai Ming Zhang

2011-01-01

333

Modeling Ablation of Fibrous Materials from Bulk to Knudsen Regime  

Science.gov (United States)

Material-environment interactions are analyzed at microscopic scale to explain the lower than expected density observed by post-flight analysis of the char layer on the Stardust shield. Mass transfer, ablation (oxidation), and surface recession of fibrous material is simulated in 3D using a Monte-Carlo simulation tool. Ablation is found to occur either at the surface or in volume depending on Knudsen and Thiele number values. This study supports the idea of volume ablation followed by possible carbon fiber spallation that may explain post-flight analyses.

Lachaud, Jean; Mansour, Nagi N.

2008-01-01

334

Development of fibrous monoliths from mullite, alumina, and zirconia powders  

Energy Technology Data Exchange (ETDEWEB)

Fibrous monoliths (FMs) based on mullite combined with Al{sub 2}O{sub 3} and Y{sub 2}O{sub 3}-stabilized ZrO{sub 2} have been produced. These FMs incorporate duplex cells in which compressive residual stresses were engineered into the surfaces of the cells. The residual stresses should increase average cell strength, which may allow them to achieve mechanical properties comparable to those of Si{sub 3}N{sub 4}/BN FMs. The expected residual stresses have been calculated, and data on sintering and thermal expansion have been gathered. Prototype FMs were produced and their microstructure examined.

Polzin, B. J.; Cruse, T. A.; Singh, D.; Picciolo, J. J.; Tsaliagos, R. N.; Phelan, P. J.; Goretta, K. C.

2000-06-29

335

Giant solitary fibrous tumors of the pleura: two case reports.  

Science.gov (United States)

Solitary fibrous tumors of the pleura (SFTP) are rare neoplasms. We report two cases of giant SFTP treated by surgical resection. One of these was enormous (30 x 19 x 18 cm, weight: 4,050 g) and occupied the entire left pleural cavity with complete lung collapse and contralateral mediastinal shift. Both tumors were removed en bloc. The patients had no postoperative complications. Surgical treatment is curative in most patients; resection must be complete because of the possibility of recurrence and metastasis. PMID:17902070

Fiorello, A; Vicidomini, G; Santini, M

2007-10-01

336

Development of flame resistant treatment for nomex fibrous structures  

Science.gov (United States)

Technology which renders aramid fibrous structures flame resistant through chemical modification was developed. The project scaled up flame resistant treatment from laboratory fabric swatches of a few inches to efficiently producing ten yards of commercial width (41 inches) aromatic polyamide. The radiation intensity problem of the processor was resolved. Further improvement of the processor cooling system was recommended for two reasons: (1) To advance current technology of flame proofing Nomex fabric to higher oxygen enriched atmospheres; and (2) To adapt the processor for direct applicability to low cost commercial fabrics.

Toy, M. S.

1978-01-01

337

Undetermined Fibrous Tumor with Calcification in the Cerebellopontine Angle  

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In this report, we introduce an undetermined fibrous tumor with calcification occurring in the cerebellopontine angle (CPA). A 51-year-old woman was admitted with a short history of dizziness. Computed tomography and magnetic resonance images revealed a 2×2×2 cm sized mass at the left CPA which was round and calcified. There was no dura or internal auditory canal involvement. At surgery, the tumor was located at the exit of 7th and 8th cranial nerve complex. It was very firm, bright yellow ...

Cheon, Se Hun; Kang, Shin-hyuk; Park, Kyung Jae; Chung, Yong Gu

2010-01-01

338

Solitary fibrous tumor of the parotid gland: Case report  

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Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm that usually develops in the pleura and peritoneum. The head and neck region is involved in only 6% of the cases. Involvement of the parotid gland is a rare phenomenon, with only 24 cases reported in the literature. The aim of this study is to report an additional case of SFT affecting the parotid gland, and to review the literature on previously reported cases. The patient was a 42-year-old male with a 4-cm, fibro-elastic, movable,...

Sousa, Alexandre A.; Souto, Giovanna R.; Sousa, Isabela A.; Mesquita, Ricardo A.; Gomez, Ricardo S.; Jham, Bruno C.

2013-01-01

339

Solitary fibrous tumor of the orbit presenting in pregnancy  

Directory of Open Access Journals (Sweden)

Full Text Available A 32-year-old woman, three months pregnant, reported with the complaint of protrusion of the right eye for six months. She gave history of rapid protrusion of eyeball for the last two months along with the history of double vision for the last one month. Computer tomography (CT scan revealed a well-defined mass lesion in the intraconal space of the right orbit which was excised through a lateral orbitotomy approach. Histological examination and immunohistochemistry revealed a solitary fibrous tumor, which showed a rapid progression in pregnancy.

Das Jayanta

2009-01-01

340

BMP-2-loaded silica nanotube fibrous meshes for bone generation  

International Nuclear Information System (INIS)

Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol–gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

 
 
 
 
341

The use of fibrous ion exchangers in gold hydrometallurgy  

Science.gov (United States)

This article examines a family of ion-exchange fibers, FIBAN, containing primary and secondary amine groups. These ion exchangers have a fiber diameter of 20 40 ?m, high osmotic and mechanic stability, a high rate of adsorption and regeneration, and excellent dynamic characteristics as filtering media. Inparticular, this article discusses the use of FIBAN fibrous ion exchangers in the recovery of gold cyanide andbase-metal cyanides (copper and mercury) from mineral-leaching solutions. The influence of polymer structure and water content on their extraction ability is described, along with key parameters of gold hydrometallurgy such as extraction efficiency, selectivity, pH dependence, gold cyanide loading, kinetics, and stripping.

Kautzmann, R. M.; Sampaio, C. H.; Cortina, J. L.; Soldatov, V.; Shunkevich, A.

2002-10-01

342

Malignant tumors of childhood  

International Nuclear Information System (INIS)

This book contains 34 papers about malignant tumors. some of the titles are: Invasive Cogenital Mesoblastic Nephroma, Leukemia Update, Unusual Perinatal Neoplasms, Lymphoma Update, Gonadal Germ Cell Tumors in Children, Nutritional Status and Cancer of Childhood, and Chemotherapy of Brain tumors in Children

343

Primary mucosal malignant melanoma  

International Nuclear Information System (INIS)

Primary malignant melanoma of the vagina and esophagus are reported and the literature on the subject is extensively reviewed. The role of large fraction irradiation is appraised. In both cases, no exenterative surgery was imposed but instead, intermittent large fraction irradiation with protracted high doses was elected for local control. (Auth.)

344

Malignant pleural mesothelioma  

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Malignant mesothelioma is one of the rare tumors of pleura. One such case in a 57-year-old male, who presented with hemorrhagic pleural effusion and had no history of asbestos exposure, is reported here. The rarity, unusual presentation, and implications are discussed.

Rao Sukhesh

2009-01-01

345

Malignant melanoma (metastatic)  

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There are 8100 new cases of malignant melanoma and 1800 deaths a year in the UK, largely as a result of metastatic disease. The median survival of people with metastatic melanoma is 6 to 9 months after diagnosis, with 10% of people alive at 5 years.Chemotherapy is given with palliative rather than curative intent for metastatic disease.

Larkin, James; Gore, Martin

2008-01-01

346

[Resection of sternal lesion and its reconstruction].  

Science.gov (United States)

Our experience of seven cases with resection and reconstruction of sternum were introduced. The lesions were 1 chondrosarcoma, 1 malignant fibrous histiocytoma, 1 myeloma, 1 fibrous dysplasia, 1 thymic carcinoma and 2 recurrent breast carcinomas. Partial resection of sternum was performed in 6 and subtotal resection in 1. In reconstruction of sternum we have used frequently Marlex mesh for prosthetic material, and pedicled pectoralis major muscle flap and/or rectus abdominis musculocutaneous flap for overlying the prosthesis. All patients are living and well for except one case. PMID:8558802

Shirakusa, T

1996-01-01

347

Radiation associated malignant pleural mesothelioma  

Energy Technology Data Exchange (ETDEWEB)

Malignant pleural mesothelioma of epithelial type developed in a 24 year old woman, 20 years after radiotherapy for Hodgkin's disease. This case and a review of published cases indicate that radiation may induce malignant mesothelioma. (author).

Lerman, Yehuda (Israel Defence Forces Medical Corps. (Israel)); Learman, Y. (Beilinson Medical Center, Petah Tiqva (Israel)); Schachter, P.; Herceg, E.; Lieberman, Y.; Yellin, A. (Chaim Sheba Medical Center, Ramat Gan (Israel))

1991-06-01

348

Radiation associated malignant pleural mesothelioma  

International Nuclear Information System (INIS)

Malignant pleural mesothelioma of epithelial type developed in a 24 year old woman, 20 years after radiotherapy for Hodgkin's disease. This case and a review of published cases indicate that radiation may induce malignant mesothelioma. (author)

349

Image diagnosis of malignant mesothelioma  

International Nuclear Information System (INIS)

3 cases of malignant mesothelioma confirmed by pathological examination were reported. CT showed solid mass with moderate enhancement by contrast medium. CT appears to be a very useful tool to make a diagnosis of malignant mesothelioma. (author)

350

Drugs Approved for Malignant Mesothelioma  

Science.gov (United States)

... the Food and Drug Administration (FDA) for malignant mesothelioma. The list includes generic names and brand names. ... summaries. There may be drugs used in malignant mesothelioma that are not listed here.

351

Radiation associated malignant pleural mesothelioma.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Malignant pleural mesothelioma of epithelial type developed in a 24 year old woman, 20 years after radiotherapy for Hodgkin's disease. This case and a review of published cases indicate that radiation may induce malignant mesothelioma.

Lerman, Y.; Learman, Y.; Schachter, P.; Herceg, E.; Lieberman, Y.; Yellin, A.

1991-01-01

352

Diffuse malignant pleural mesothelioma in an urban hospital: Clinical spectrum and trend in incidence over time  

Energy Technology Data Exchange (ETDEWEB)

This retrospective analysis reviews the clinical experience of a major urban referral hospital with diffuse malignant pleural mesothelioma during the 14-year period from 1973 through 1986. Seventy-five cases of definite or equivocal mesothelioma were identified. There were four cases of primary malignant peritoneal mesothelioma, seven cases of benign fibrous mesothelioma, and 64 cases of diffuse malignant pleural mesothelioma. In 43 cases (67%) of diffuse malignant pleural mesothelioma, there was historic evidence of asbestos exposure. In 21 cases (33%), there was no known history of asbestos exposure. An increase in annual incidence of diffuse malignant pleural mesothelioma was observed over the study period, from three cases in 1973 to ten cases in 1986. Despite greater awareness of this disease, the diagnosis remains a difficult one to establish given the nonspecific symptoms, signs and radiographic appearance, variable histologic appearance, and poor diagnostic sensitivity and specificity of thoracentesis and closed pleural biopsy. Thoracotomy, thoracoscopy, and CT-guided needle biopsies gave higher yields and are the diagnostic measures of choice when diffuse malignant pleural mesothelioma is suspected.

Shepherd, K.E.; Oliver, L.C.; Kazemi, H. (Massachusetts General Hospital, Boston (USA))

1989-01-01

353

Diffuse malignant pleural mesothelioma in an urban hospital: Clinical spectrum and trend in incidence over time  

International Nuclear Information System (INIS)

This retrospective analysis reviews the clinical experience of a major urban referral hospital with diffuse malignant pleural mesothelioma during the 14-year period from 1973 through 1986. Seventy-five cases of definite or equivocal mesothelioma were identified. There were four cases of primary malignant peritoneal mesothelioma, seven cases of benign fibrous mesothelioma, and 64 cases of diffuse malignant pleural mesothelioma. In 43 cases (67%) of diffuse malignant pleural mesothelioma, there was historic evidence of asbestos exposure. In 21 cases (33%), there was no known history of asbestos exposure. An increase in annual incidence of diffuse malignant pleural mesothelioma was observed over the study period, from three cases in 1973 to ten cases in 1986. Despite greater awareness of this disease, the diagnosis remains a difficult one to establish given the nonspecific symptoms, signs and radiographic appearance, variable histologic appearance, and poor diagnostic sensitivity and specificity of thoracentesis and closed pleural biopsy. Thoracotomy, thoracoscopy, and CT-guided needle biopsies gave higher yields and are the diagnostic measures of choice when diffuse malignant pleural mesothelioma is suspected

354

Malignant Melanoma of the Foot  

Science.gov (United States)

... of the Foot Text Size Print Bookmark Malignant Melanoma of the Foot What is Malignant Melanoma? Melanoma is a cancer that begins in the cells ... produce pigmentation (coloration). It is also called malignant melanoma because it spreads to other areas of the ...

355

Malignant Mesothelioma of Tunica Vaginalis  

Directory of Open Access Journals (Sweden)

Full Text Available Mesothelioma is often diagnosed as a malignant scrotal mass without pain or inflammatory signs. It is a very rare tumor with quite uncommon sites of involvement. This form of malignancy generally involves pleura, with a differential diagnosis of undifferentiated carcinoma expectable in this area related to epididymis and rete testis. Keywords: Malignant mesothelioma, Scrotal mass

M Mokhtari

2004-02-01

356

A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots  

Directory of Open Access Journals (Sweden)

Full Text Available The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus. From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-?-D-glucopyranoside and three known glycosides [1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (liriopeoside A, 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside, and 1?,6?-dihydroxy-5,10-bis-epi-eudesm-4(15-ene-6-O-? D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-?-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC50 value of 339.76 ?g/mL, while liriopeoside A (LC50 = 82.84 ?g/mL and 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (LC50 = 153.39 ?g/mL also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC50 value of 182.56 ?g/mL.

Yong Yan Wang

2011-10-01

357

A new eudesmane sesquiterpene glucoside from Liriope muscari fibrous roots.  

Science.gov (United States)

The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus). From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-?-D-glucopyranoside) and three known glycosides [1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (liriopeoside A), 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside, and 1?,6?-dihydroxy-5,10-bis-epi-eudesm-4(15)-ene-6-O-? D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-?-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC(50 )value of 339.76 ?g/mL, while liriopeoside A (LC(50) = 82.84 ?g/mL) and 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (LC(50) = 153.39 ?g/mL) also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC(50) value of 182.56 ?g/mL. PMID:22031065

Zhang, Hai Ming; Wang, Gang Li; Bai, Chun Qi; Liu, Peng; Liu, Zi Mu; Liu, Qi Zhi; Wang, Yong Yan; Liu, Zhi Long; Du, Shu Shan; Deng, Zhi Wei

2011-01-01

358

Heat Transfer Modeling for Rigid High-Temperature Fibrous Insulation  

Science.gov (United States)

Combined radiation and conduction heat transfer through a high-temperature, high-porosity, rigid multiple-fiber fibrous insulation was modeled using a thermal model previously used to model heat transfer in flexible single-fiber fibrous insulation. The rigid insulation studied was alumina enhanced thermal barrier (AETB) at densities between 130 and 260 kilograms per cubic meter. The model consists of using the diffusion approximation for radiation heat transfer, a semi-empirical solid conduction model, and a standard gas conduction model. The relevant parameters needed for the heat transfer model were estimated from steady-state thermal measurements in nitrogen gas at various temperatures and environmental pressures. The heat transfer modeling methodology was evaluated by comparison with standard thermal conductivity measurements, and steady-state thermal measurements in helium and carbon dioxide gases. The heat transfer model is applicable over the temperature range of 300 to 1360 K, pressure range of 0.133 to 101.3 x 10(exp 3) Pa, and over the insulation density range of 130 to 260 kilograms per cubic meter in various gaseous environments.

Daryabeigi, Kamran; Cunnington, George R.; Knutson, Jeffrey R.

2012-01-01

359

Formation of fibrous materials from dense calcium caseinate dispersions.  

Science.gov (United States)

Application of shear and cross-linking enzyme transglutaminase (Tgase) induced fibrous hierarchical structures in dense (30% w/w) calcium caseinate (Ca-caseinate) dispersions. Using Tgase was essential for the anisotropic structure formation. The fibrous materials showed anisotropy on both micro- and macroscale as determined with scanning electron microscopy (SEM) and mechanical analyses, respectively. SEM revealed protein fibers with a diameter of approximately 100-200 nm; visually, we observed fibers of about 1 mm. Both shear and Tgase affected the reinforcement of the fibers to a large extent, whereas the mechanical properties in the direction perpendicular to the shear flow remained constant. Shearing Ca-caseinate without Tgase yielded a slightly anisotropic layered structure. Both cross-linking in the absence of shear and cross-linking during mixing resulted in gels without alignment. The formation of shear- and enzyme-induced anisotropic structures was explained by aligning of protein aggregates due to shear and concurrent solidification of the aligned protein aggregates. PMID:17326681

Manski, Julita M; van der Goot, Atze J; Boom, Remko M

2007-04-01

360

Fibrous Fillers to Manufacture Ultra High Ash/Performance Paper  

Energy Technology Data Exchange (ETDEWEB)

The paper industry is one of the largest users of energy and emitters of CO2 in the US manufacturing industry. In addition to that, it is facing tremendous financial pressure due to lower cost imports. The fine paper industry has shrunk from 15 million tons per year production to 10 million tons per year in the last 5 years. This has resulted in mill closures and job loses. The AF&PA and the DOE formed a program called Agenda 2020 to help in funding to develop breakthrough technologies to provide help in meeting these challenges. The objectives of this project were to optimize and scale-up Fibrous Fillers technology, ready for commercial deployment and to develop ultra high ash/high performance paper using Fibrous Fillers. The goal was to reduce energy consumption, carbon footprint, and cost of manufacturing paper and related industries. GRI International (GRI) has been able to demonstrate the techno - economic feasibility and economic advantages of using its various products in both handsheets as well as in commercial paper mills. GRI has also been able to develop sophisticated models that demonstrate the effect of combinations of GRI's fillers at multiple filler levels. GRI has also been able to develop, optimize, and successfully scale-up new products for use in commercial paper mills.

Dr. VIjay K. Mathur

2009-04-30

 
 
 
 
361

Prosthetic reconstruction after surgical resection of fibrous dysplasia of the maxillary and palatine bone.  

Science.gov (United States)

Fibrous dysplasia is a rare disorder of the bone. It is seen in two main forms of presentation: monostotic and the polyostotic. A case of monostotic fibrous dysplasia of the maxillary and palatine bones in a 22-year old man who received prosthetic reconstruction is presented with a review of the literature. PMID:23155991

Cherkaoui, A; Nawar, O; Fouad, I; Najib, B; El, Alami N

2012-06-01

362

RECENT DEVELOPMENTS IN ANALYTICAL METHODS FOR FIBROUS AMPHIBOLE IN VERMICULITE ATTIC INSULATION  

Science.gov (United States)

The U.S. Environmental Protection Agency has developed a test method for the analysis of fibrous amphibole in vermiculite attic insulation. This method was developed to provide the Agency with monitoring tools to study the occurrence and potential for exposure to fibrous amphibo...

363

Evaluation of different measurements for effective thermal conductivity of fibrous materials  

Directory of Open Access Journals (Sweden)

Full Text Available Effective thermal conductivity is generally recognized as the intrinsic factor to reveal the thermal responses of fibrous materials. Here, two typical measurements, the step-wise transient method and the guarded hot plate method, were utilized to identify their feasibility for the effective thermal conductivity of fibrous materials (non-woven fabric and twill fabric with different stacking layers.

Tian Ming-Wei

2014-01-01

364

Hyaluronan in human malignancies  

International Nuclear Information System (INIS)

Hyaluronan, a major macropolysaccharide in the extracellular matrix of connective tissues, is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of various human tumors and modulates intracellular signaling pathways, cell proliferation, motility and invasive properties of malignant cells. Experimental and clinicopathological evidence highlights the importance of hyaluronan in tumor growth and metastasis. A high stromal hyaluronan content is associated with poorly differentiated tumors and aggressive clinical behavior in human adenocarcinomas. Instead, the squamous cell carcinomas and malignant melanomas tend to have a reduced hyaluronan content. In addition to the stroma-cancer cell interaction, hyaluronan can influence stromal cell recruitment, tumor angiogenesis and epithelial-mesenchymal transition. Hyaluronan receptors, hyaluronan synthases and hyaluronan degrading enzymes, hyaluronidases, are involved in the modulation of cancer progression, depending on the tumor type. Furthermore, intracellular signaling and angiogenesis are affected by the degradation products of hyaluronan. Hyaluronan has also therapeutic implications since it is involved in multidrug resistance.

365

Hyaluronan in human malignancies  

Energy Technology Data Exchange (ETDEWEB)

Hyaluronan, a major macropolysaccharide in the extracellular matrix of connective tissues, is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of various human tumors and modulates intracellular signaling pathways, cell proliferation, motility and invasive properties of malignant cells. Experimental and clinicopathological evidence highlights the importance of hyaluronan in tumor growth and metastasis. A high stromal hyaluronan content is associated with poorly differentiated tumors and aggressive clinical behavior in human adenocarcinomas. Instead, the squamous cell carcinomas and malignant melanomas tend to have a reduced hyaluronan content. In addition to the stroma-cancer cell interaction, hyaluronan can influence stromal cell recruitment, tumor angiogenesis and epithelial-mesenchymal transition. Hyaluronan receptors, hyaluronan synthases and hyaluronan degrading enzymes, hyaluronidases, are involved in the modulation of cancer progression, depending on the tumor type. Furthermore, intracellular signaling and angiogenesis are affected by the degradation products of hyaluronan. Hyaluronan has also therapeutic implications since it is involved in multidrug resistance.

Sironen, R.K. [Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Department of Pathology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland); Tammi, M.; Tammi, R. [Institute of Biomedicine, Anatomy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Auvinen, P.K. [Department of Oncology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland); Anttila, M. [Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Department of Gynecology and Obstetrics, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland); Kosma, V-M., E-mail: Veli-Matti.Kosma@uef.fi [Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio (Finland); Department of Pathology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio (Finland)

2011-02-15

366

Trisomies in Hematologic Malignancies  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.., trisomies ? are also frequent. Little is known about the biologic outcome, the pathogenetic significance, or the mechanism behind the formation of the latter genetic changes. The aim of the present t...

Paulsson, Kajsa

2005-01-01

367

Helicobacter and Gastric Malignancies  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Individuals infected with Helicobacter pylori, a stomach colonizing bacteria, have an increased risk of developing gastric malignancies. The risk for developing cancer relates to the physiologic and histologic changes that H. pylori infection induces in the stomach. In the last year numerous studies have been conducted in order to characterize the association between H. pylori infection and gastric cancer. These studies range from epidemiologic approaches aiming at the identification of envir...

Ferreira, Anto?nio Carlos; Isomoto, Hajime; Moriyama, Masatsugu; Fujioka, Toshio; Machado, Jose? Carlos; Yamaoka, Yoshio

2008-01-01

368

Intravascular malignant lymphomatosis  

International Nuclear Information System (INIS)

Intravascular malignant lymphomatosis is a rare and probably often overlooked disease characterised by massive intravascular proliferation of lymphoid cells, usually with a poor prognosis. CT and MRI appearances are nonspecific; the most suggestive finding being both asymmetrical, bilateral, contrast enhancing high-signal areas on T2 weighting and infarct-like lesions of the cortex and basal ganglia. We report two patients with previously unreported dural and spinal cord involvement. (orig.)

369

Intravascular malignant lymphomatosis  

Energy Technology Data Exchange (ETDEWEB)

Intravascular malignant lymphomatosis is a rare and probably often overlooked disease characterised by massive intravascular proliferation of lymphoid cells, usually with a poor prognosis. CT and MRI appearances are nonspecific; the most suggestive finding being both asymmetrical, bilateral, contrast enhancing high-signal areas on T2 weighting and infarct-like lesions of the cortex and basal ganglia. We report two patients with previously unreported dural and spinal cord involvement. (orig.)

Martin-Duverneuil, N.; Lafitte, F.; Chiras, J. [Service de Neuroradiologie Charcot, Batiment Babinski, Hopital de la Salpetriere, 75013 Paris (France); Mokhtari, K. [Service de Neuropathologie, Hopital de la Salpetriere, 75013 Paris (France); Behin, A.; Hoang-Xuan, K. [Departement de Neurologie, Hopital de la Salpetriere, 75013 Paris (France)

2002-09-01

370

MALIGNANT DISEASE OF CHILDREN  

Digital Repository Infrastructure Vision for European Research (DRIVER)

ABSTRACT The diploma first introduces key epidemiological data and after that biological basics of cancer in children in a more integral way. According to our findings, the reasons for malignant disease formation are mostly genetic factors. This is then followed by a review of cancer classification in children and adolescents – 12 classification groups that are defined on the basis of histological picture. A detailed description of signs and symptoms of particularly frequent types of ...

Kerin-kos, Sonja

2009-01-01

371

Malignancies following lung transplantation.  

Science.gov (United States)

During the last 2 decades, long-term survival after lung transplantation has significantly improved. However, among the complications related to the continuous administration of immunosuppressive drugs, malignancy plays an important role. We retrospectively revisited our series of patients to report our experience. From January 1991 we performed 134 lung transplantations in 128 recipients (mean age, 33.4 +/- 13.5 years). In all patients the first-line immunosuppressive regimen was based on a calcineurin inhibitor (cyclosporine or tacrolimus), an antimetabolic agent (azathioprine), and steroids. Five patients (4.2%) developed malignancy and the mean time of occurrence after the transplantation was 46.4+/-23 months. The mean age was 41 +/- 16 years (P = not significant [ns]). The tumors were as follows: laryngeal cancer (radiotherapy), colon cancer (surgery plus adjuvant chemotherapy), gastric cancer (surgery plus adjuvant chemotherapy), endobronchial non-Hodgkin lymphoma (NHL) (endoscopic resection plus chemoradiotherapy), and cutaneous and visceral Kaposi's sarcoma (KS) (chemotherapy). All patients have reduced the dose of immunosuppressive drugs; in 1 of them, tacrolimus was changed to rapamycin. Two patients died because of neoplastic dissemination, another 1 due to obliterans bronchiolitis. The 2 patients with NHL and KS are alive at 6 and 9 months, respectively, without signs of recurrence. Malignancies after lung transplantation represent an important problem. A multidisciplinary approach is mandatory to obtain satisfactory results in terms of improved quality of life and long-term survival. PMID:17692672

Anile, M; Venuta, F; Diso, D; De Giacomo, T; Rendina, E A; Rolla, M; Ruberto, F; Liparulo, V; Aratari, M T; Di Stasio, M; Ricella, C; Vitolo, D; Longo, F; Coloni, G F

2007-01-01

372

Malignant intraocular tumors  

International Nuclear Information System (INIS)

The role of the radiation therapist in the management of malignant intraocular tumors is changing. With more active identification of malignant intraocular tumors, and a better recognization of the manner in which one can deal with problems of radiation sensitivity, radiation techniques of all sorts will be more actively employed in the treatment of these tumors. Special techniques must be selected for appropriate circumstances of management in order to diminish to an absolute minimum the impact upon the lens, the impact upon visual acuity and the impact upon the cornea. Cobalt-60 plaques are being used more commonly in the treatment of melanomas of the choroid, and the role for radiation therapy in the management of retinoblastoma is changing markably to where it may be used as the primary treatment program rather than enucleation. In metastatic disease involving the uveal tract, radiation therapy has assumed the most important role for management. Chemotherapy should be considered as an active adjuvant in the management of not only those individuals with retinoblastoma but also in those identified circumstances where metastases to the uveal tract are being treated. The role for chemotherapy or immunotherapy in malignant melanoma is unclear

373

Malignant peritoneal mesothelioma  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant mesothelioma is a highly aggressive neoplasm. The incidence of malignant mesothelioma is increasing worldwide. Diffuse malignant peritoneal mesothelioma (DMPM represents one-fourth of all mesotheliomas. Association of asbestos exposure with DMPM has been observed, especially in males. The great majority of patients present with abdominal pain and distension, caused by accumulation of tumors and ascitic fluid. In the past, DMPM was considered a pre-terminal condition; therefore attracted little attention. Patients invariably died from their disease within a year. Recently, several prospective trials have demonstrated a median survival of 40 to 90 mo and 5-year survival of 30% to 60% after combined treatment using cytoreductive surgery and perioperative intraperitoneal chemotherapy. This remarkable improvement in survival has prompted new search into the medical science related to DMPM, a disease previously ignored as uninteresting. This review article focuses on the key advances in the epidemiology, diagnosis, staging, treatments and prognosis of DMPM that have occurred in the past decade.

Stine Munkholm-Larsen

2009-11-01

374

Fabrication and EM shielding properties of electrospining PANi/MWCNT/PEO fibrous membrane and its composite  

Science.gov (United States)

In this paper, Polyaniline-based fibrous membranes were fabricated with multi-walled carbon nanotubes and polyethylene oxide (PEO) by the electrospinning method. And then PANi/PEO/MWCNT fibrous membranes reinforced epoxy based nanocomposite was then fabricated. The morphology and electrical properties of PANi /MWCNT /PEO fibrous membrane was characterized by scanning electron microscope (SEM). The morphologies of the membranes indicate that the electrospining method can fabricate well nano structures fibrous membrane. The EM properties of the composite reinforced with the electrospining fibrous membrane were measured by vector network analyzer. The results show that the permittivity real, image parts and permeability real part of the composite increase by filling with PANI/PEO and PANI/CNT/PEO membrane. The EM shielding and absorb performance is base on the dielectric dissipation. And different membranes made of different materials show different EM parameter, and different EM shielding performance, which can be used to the EM shielding and stealth material design and fabrication.

Zhang, Zhichun; Jiang, Xueyong; Liu, Yanju; Leng, Jinsong

2012-04-01

375

An epidemiological and clinical analysis of craniomaxillofacial fibrous dysplasia in a Chinese population  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Craniomaxillofacial fibrous dysplasia (FD is a benign bone lesion characterized by facial disfigurement and functional impairment. The aim of this study was to characterize the epidemiological and clinical features of craniomaxillofacial FD by presenting data from a representative Chinese population during a 15-year period (1994–2009. Method The craniomaxillofacial disease registries of two Chinese tertiary referral hospitals (Shanghai Ninth People’s Hospital and Stomatological hospital of Jiangsu Province were searched and reviewed to collect relevant information for patients with craniomaxillofacial FD between Jan.1994 and Dec.2009. All included cases were further analyzed with regard to associated epidemiological and clinicopathological variables. Results A total number of 266 cases with definitive diagnosis were identified with 219 primary cases and 47 recurrent cases. There were 111 males and 155 females with a male to female ratio of 0.716:1. They were clinically categorized into three groups: monostotic (71.1%, polysotic (27.4% and Albright syndrome (1.5%. Maxilla alone or with adjacent bones was the most common affected site. The serum alkaline phosphatase (ALP in patients was much higher than that in healthy control, whereas comparable between primary patients and recurrent ones. Three patients (3/266, 1.1% with polysotic lesions underwent spontaneous malignant transformation into osteosarcoma. The majority of patients underwent conservative surgery, while the others received radical resection with or without reconstruction. Conclusions Craniomaxillofacial FD is a rare bony disorder with defined epidemiological and clinicopathological features in Chinese population. Further investigations are warranted to establish the optimized timing, treatment strategy and prognostic prediction for this clinical entity.

Cheng Jie

2012-10-01

376

Benign fibrous histocytoma of femur: a case report.  

Science.gov (United States)

Benign fibrous histocytoma (BFH) is a rare benign tumor, commonly occurs in soft tissues with very few cases in bone recorded. BFH of bone usually occurs in patients after the age of 20 years and often locates in the epiphysis or diaphysis of tubular bones, especially the femur and tibia. Herein we report a case of BFH of femur. The radiography and CT scan revealed a well-defined unilocular osteolytic lesion in the left proximal femur with marginal sclerosis. MRI showed that the lesion was isointense on T1WI, heterogeneous hyperintense on fat-saturated T2WI, with hypointense ring in circumference. Intralesional curettage was performed. At pathological examination, the tumor was consisted of spindle-shaped cells and scattered histocytic cells. The final diagnosis of BFH was established. PMID:23256085

Chen, Wen; Gu, Tao

2012-09-01

377

Determination of physical properties of fibrous thermal insulation  

Directory of Open Access Journals (Sweden)

Full Text Available The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a device developed in house. The radiative properties of the material are determined by an inverse method based on measurements of transmittance and reflectance using a FTIR spectrometer and by solving the equation of radiative heat transfer. These measures are compared to results of numerical simulations.

Jeandel G.

2012-10-01

378

Infiltration of fibrous preform in the centrifugal force field  

Energy Technology Data Exchange (ETDEWEB)

The pressure to infiltrate molten aluminum into alumina short fiber preform was generated by centrifugal force, and the start pressure for the infiltration was measured. The fundamental equation of infiltration phenomenon was derived from the equation of the conservation of momentum of fluid flow in the porous media in the centrifugal force field. One-dimensional solution of the equation was obtained to discuss the characteristics of fluid flow in a centrifugal force field. It was made clear that centrifugal force is effective as a motive force to infiltrate molten metal into fibrous preform, the pressure distribution of molten metal in the preform is different from that predicted by D`Arcy`s law and the infiltration is enhanced by centrifugal force.

Nishida, Yoshinori; Shirayanagi, Itaru [National Industrial Research Inst. of Nagoya (Japan); Sakai, Yoshibumi; Tozawa, Yasuhisa [Daido Inst. of Tech., Nagoya (Japan)

1994-12-31

379

Fabrication and characterization of oxide fibrous monoliths produced by coextrusion.  

Energy Technology Data Exchange (ETDEWEB)

Unidirectional fibrous monoliths (FMs) based on dense, strong ZrSiO{sub 4} cells that were surrounded by a porous, weaker ZrSiO{sub 4} cell-boundary phase were fabricated. A duplex filament was coextruded, sectioned, bundled, and the resulting bundle was extruded to form a new filament. This filament was cut and packed into plate and bar dies to produce FM test specimens. Four-point flexural tests were conducted on the cell material, cell-boundary material, and FMs. After testing, fracture surfaces and cross sections were examined by scanning electron microscopy. The FMs exhibited graceful failure in flexural testing, and the fracture surfaces exhibited clear evidence of crack deflection and delamination.

Polzin, B. J.

1999-05-19

380

Effect of microaerobic fermentation in preprocessing fibrous lignocellulosic materials.  

Science.gov (United States)

Amending soil with organic matter is common in agricultural and logging practices. Such amendments have benefits to soil fertility and crop yields. These benefits may be increased if material is preprocessed before introduction into soil. We analyzed the efficiency of microaerobic fermentation (MF), also referred to as Bokashi, in preprocessing fibrous lignocellulosic (FLC) organic materials using varying produce amendments and leachate treatments. Adding produce amendments increased leachate production and fermentation rates and decreased the biological oxygen demand of the leachate. Continuously draining leachate without returning it to the fermentors led to acidification and decreased concentrations of polysaccharides (PS) in leachates. PS fragmentation and the production of soluble metabolites and gases stabilized in fermentors in about 2-4 weeks. About 2 % of the carbon content was lost as CO(2). PS degradation rates, upon introduction of processed materials into soil, were similar to unfermented FLC. Our results indicate that MF is insufficient for adequate preprocessing of FLC material. PMID:22639359

Alattar, Manar Arica; Green, Terrence R; Henry, Jordan; Gulca, Vitalie; Tizazu, Mikias; Bergstrom, Robby; Popa, Radu

2012-06-01

 
 
 
 
381

Fabrication of hierarchical ZnO enriched fibrous PVA membrane.  

Science.gov (United States)

We have demonstrated herein a simple method for the fabrication of hierarchical structure of ZnO enriched fibrous PVA membrane. The observed result has shown the uniform coating of ZnO on the fiber surface. Effective control of the density of coating has been brought about by changing the concentration of ZnO and combined sol-gel coating. Serving as seeds for the growth of nanorods, the ZnO nuclei evolve to form nanorods whose density and length have been controlled by thermal treatment. We believe that the methodology described in this report offers a simple and straightforward route to prepare the hybrid structure and furthermore find an exercise in various optoelectronic fields. PMID:23862483

Anitha, S; Natarajan, T S

2013-06-01

382

Solitary fibrous tumor of the liver: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Hepatic solitary fibrous tumor (SFT is a rare tumor originating from the mesenchyme. Here we report a new case of SFT in the liver and review the clinical presentation, radiological and operative findings, diagnosis, treatment, and outcome. The patient was a 59-year-old man who presented with progressive fatigue for 3 months and an abdominal mass for 3 days. On laboratory tests, no abnormality was detected except that abdominal ultrasonography revealed a 9.0 × 6.2 cm hypoechogenic mass in the left lobe of the liver. A computed tomographic scan confirmed a hypodense lesion in the left lobe of the liver. The patient underwent left hepatectomy. SFT was diagnosed on the basis of histopathological findings. The patient was free from all symptoms and had no signs of local recurrence after 24 months' follow up.

Ying Li-Xiong

2011-03-01

383

Pharmacological and safety evaluation of fibrous root of Rhizoma Coptidis.  

Science.gov (United States)

The aim of this study was to investigated the pharmacological activities and safety of fibrous root of Rhizoma Coptidis (FRC). FRC not only protected Kunming mice from the minimal lethal dose of Escherichia coli, but also protected rabbits from hyperpyrexia induced by lipopolysaccharid (LPS). The acute toxicity study showed that oral medial lethal dose (LD50) of FRC was greater than 7000mg/kg body weight in Kunming mice. The sub-chronic toxicity study showed that the no-observed-adverse effect level (NOAEL) of FRC was 1.88g/kg body weight in Sprague-Dawley rats, whereas FRC at higher dose (3.76g/kg body weight) resulted in damage to liver and lung. Negative results were present in Ames test, mouse micronucleus test and mouse sperm abnormality test. These finding support the use of FRC in veterinary medicine. PMID:25434762

Ning, Na; Wang, Yan Zhi; Zou, Zong Yao; Zhang, De Zhou; Wang, De Zhen; Li, Xue Gang

2014-11-15

384

Characterization of three fibrous insulations for potential HTGR application  

Energy Technology Data Exchange (ETDEWEB)

Three fibrous insulation materials manufactured by Babcock and Wilcox were characterized for possible use as HTGR core thermal insulations. These materials (Unifelt 3000 board, Unifelt 2600 board, and Kaowool blanket) were characterized by spectrographic analysis, x-ray diffractometry, scanning electron microscopy, ignition studies and bulk density measurements, resilience tests, helium permeation tests, and compressive stress-strain tests. Of these properties, resilience is the most important for determining acceptability of material for HTGR use. The arbitrary resilience acceptability criterion is 90% or greater after 20 h at 816/sup 0/C (1500/sup 0/F). Based on the resilience test, the Unifelt 3000 was acceptable, the Unifelt 2600 was marginal, and the Kaowool was unacceptable.

Selle, J. E.

1980-11-01

385

Determination of physical properties of fibrous thermal insulation  

Science.gov (United States)

The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET) with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool) are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a device developed in house. The radiative properties of the material are determined by an inverse method based on measurements of transmittance and reflectance using a FTIR spectrometer and by solving the equation of radiative heat transfer. These measures are compared to results of numerical simulations.

Tilioua, A.; Libessart, L.; Joulin, A.; Lassue, S.; Monod, B.; Jeandel, G.

2012-10-01

386

Oral potentially malignant disorders: Is malignant transformation predictable and preventable?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Leukoplakia is the most common potentially malignant disorder of the oral mucosa. The prevalence is approximately 1% while the annual malignant transformation ranges from 2% to 3%. At present, there are no reliable clinicopathological or molecular predicting factors of malignant transformation that can be used in an individual patient and such event can not truly be prevented. Furthermore, follow-up programs are of questionable value in this respect. Cessation of smoking habits may result in ...

Waal, Isaa?c

2014-01-01

387

Temozolomide in malignant glioma  

Directory of Open Access Journals (Sweden)

Full Text Available Gregor DresemannCenter for Neurooncology at Aerztehaus Velen, Velen, GermanyAbstract: Glioblastoma multiforme WHO grade IV (GBM is the most aggressive ­malignant glioma and the most frequent primary tumor of the central nervous system. The median ­survival of newly diagnosed GBM patients was between 9 to 12 months prior to treatment with ­temozolomide being introduced. Primary resection that is as complete as possible is recommended for malignant glioma. Conventional fractionated irradiation 55 to 60 gy with concomitant temozolomide followed by standard temozolomide 6 cycles (5/28 (EORTC/NCIC-regime published by R Stupp in 2005 is the standard of care for newly diagnosed GBM after surgery, independent of the methylation status of the MGM-T gene promoter. Age is no ­contraindication for treatment with temozolomide, although comorbidity and performance status have to be ­considered. For temozolomide naive GBM and astrocytoma grade III patients with disease progression, temozolomide is still the treatment of choice outside of clinical studies. A ­general consensus regarding the schedule of choice has not yet been achieved; so far the 5 out of 28 days regimen (5/28 is the standard of care in most countries. Patients with disease progression after standard temozolomide (5/28 are candidates for clinical studies. Outside of clinical ­studies, dose-dense (7/7, prolonged (21/28, or metronomic (28/28 temozolomide, or alternatively a nitrosourea-based regimen can be an option. The excellent toxicity profile of ­temozolomide allows for various combinations with antitumor agents. None of these ­combinations, however, have been demonstrated to be statistically significantly superior compared to temozolomide alone. The role of lower dosed, dose-dense, or continuous regimen with or without drug combination and the role of temozolomide for newly diagnosed astrocytoma grade III and low grade glioma still has to be determined.Keywords: glioblastoma multiforme, astrocytoma WHO grade III, malignant glioma, temozolomide

Gregor Dresemann

2010-07-01

388

Malignant phyllodes tumor.  

Science.gov (United States)

The study aims to evaluate the survival and prognosis of patients with malignant phyllodes tumor. Between 1982 and 1998, 37 women with malignant phyllodes tumor were treated at the Regional Cancer Center, Trivandrum. Twelve patients were recurrent. Survival was estimated using the Kaplan-Meier method. Patient, disease, and treatment factors were compared using log-rank test. The Cox-proportional hazard model was employed to identify the prognostic factors. Thirty-six patients had surgery. Twenty-five patients received postoperative radiotherapy, and 2 received chemotherapy in addition. The median follow-up was 43 months (range 1-170 months). Eight patients failed locally, and 7 of these were successfully salvaged by surgery. The 5-year overall survival was 74.2% (95% CI, 0.44 to 0.89), whereas 5-year disease-free survival was 59.6% (95% CI, 0.39 to 0.7). The margin of surgical excision was found to be the only independent prognostic factor (p=0.003). However, patients with tumor size more than 5 cm (hazard ratio 2.9) were found to have increased hazard, whereas those receiving adjuvant radiotherapy (hazard ratio 0.6), married women (hazard ratio 0.4), and those women over the age of 35 years (hazard ratio 0.7) showed a decreased hazards. Cystosarcoma phyllodes is a rare malignancy of the female breast. Surgery with adequate margins is the primary treatment. Adjuvant radiotherapy appears to improve the disease-free survival. PMID:11843853

Pandey, M; Mathew, A; Kattoor, J; Abraham, E K; Mathew, B S; Rajan, B; Nair, K M

2001-01-01

389

Imaging of gastrointestinal malignancies.  

Science.gov (United States)

Many advancements in the imaging of gastrointestinal malignancies have been seen in the past year. Endorectal ultrasound and magnetic resonance imaging with an endorectal surface coil allow for more accurate staging of the depth of bowel wall invasion by rectal carcinoma. Monoclonal antibody imaging may detect metastases not found by other modalities while computed tomography arterial portography and intraoperative ultrasound improve our ability to identify liver metastases. Endoscopic ultrasound is also useful in the preoperative assessment of esophageal cancer and pancreatic endocrine tumors. PMID:1511029

Trenkner, S W; Thompson, W M

1992-08-01

390

[Uncommon variants of malignant melanocytic neoplasms].  

Science.gov (United States)

Benign and malignant melanocytic neoplasms are relatively frequent and show a broad morphological heterogeneity. The spectrum of malignant melanomas comprises the four main types, superficial spreading malignant melanoma, nodular malignant melanoma, lentigo-maligna melanoma and acrolentiginous malignant melanoma. In addition the rare spitzoid malignant melanoma, desmoplastic malignant melanoma as well as some unusual variants of malignant melanoma can be distinguished. The latter include nevoid malignant melanoma, a form of malignant melanoma resembling benign melanocytic nevi, animal type malignant melanoma, an atypical melanocytic neoplasm with numerous melanophages and prominent melanosis resembling an atypical epithelioid blue naevus as well as regressive malignant melanoma, and representing a questionably distinct entity, balloon cell and signet-ring malignant melanomas, melanoma types with degenerative clear cell changes, as well as myxoid and osteogenic malignant melanomas that are characterized by unusual stromal changes. PMID:17846776

Mentzel, T

2007-11-01

391

A study on heat transfer characteristics of spherical and fibrous alumina nanofluids  

International Nuclear Information System (INIS)

Highlights: ? Spherical and fibrous alumina nanoparticles were prepared by pulsed wire evaporation and hydrolysis methods. ? Fibrous alumina nanofluid exhibited higher thermal conductivity enhancement than spherical one due to entangled structure of nanofibers with high aspect-ratio. ? Decreasing rate of viscosity with temperature for fibrous alumina nanofluid was much larger than that for spherical one. - Abstract: Ethylene glycol based nanofluids containing spherical/fibrous alumina nanoparticles were synthesized by pulsed wire evaporation and hydrolysis methods. The crystallographic and morphological properties of the prepared nanoparticles were analyzed by X-ray diffraction, nitrogen gas adsorption and transmission electron microscopy. The average diameter of spherical alumina nanoparticles was about 80 nm and the alumina nanofibers exhibited a high aspect ratio (length/width). The viscosity and thermal conductivity of the spherical/fibrous alumina nanofluids were experimentally measured in the temperature range from 25 to 80 °C. For the fibrous alumina nanofluid, the increase of temperature raised thermal conductivity but lowered viscosity. On the other hand, for the spherical alumina nanofluid, both thermal conductivity and viscosity were decreased with increasing temperature. In particular, the fibrous alumina nanofluid exhibited a higher enhancement of thermal conductivity than the spherical one due to the well-connected structure between entangled nanoed structure between entangled nanofibers with high aspect ratio.

392

Radiographic Differential Diagnosis Between The Fibrous Dysplasia And The Ossifying Fibroma  

Energy Technology Data Exchange (ETDEWEB)

The author observed and compared the radiographic features of 49 cases of the fibrous dysplasia and 14 cases of the ossifying fibroma in the osteoblastic or mature stage radiologically and histopathologically. The obtained results were as follows: 1. Fibrous dysplasia occurred most frequently in the 2nd decade, but ossifying fibroma in the 3rd and 4th decades, and both lesions occurred with slight predilection in females. 2. In most cases, chief complaints were painless facial swelling. And 61.1% of fibrous dysplasia occurred in the maxilla, 92.9% of ossifying fibroma in the mandible, and most of these lesions occurred in the premolar-molar region. 3. In the mandibular lesions, ossifying fibroma was shown more oval and round shape, but fibrous dysplasia was shown fusiform shape. 4. Fibrous dysplasia was shown homogeneously distributed, complete radiopaque shadow at 63%, and ossifying fibroma was shown concentric, mixed appearance of radiolucent and radiopaque shadow at 92.9%. 5. Fibrous dysplasia was entirely shown poorly outlined and blended to normal surrounding bone, but ossifying fibroma was shown well-defined border. 6. Cortical thinning and expansion were observed in these lesions, but degree of cortical expansion was more severe in ossifying fibroma than fibrous dysplasia. 7. Loss of lamina dura, tooth displacement, and displacement of mandibular canal were observed in both lesions, but root resorption was observed in ossifying fibroma only.

Choi, Karp Shik [Dept. of Dental Radiology, College of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

1999-02-15

393

Ibrutinib for B cell malignancies  

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Research over the role of Bruton’s agammaglobulinemia tyrosine kinase (BTK) in B-lymphocyte development, differentiation, signaling and survival has led to better understanding of the pathogenesis of B-cell malignancies. Down-regulation of BTK activity is an attractive novel strategy for treating patients with B-cell malignancies. Ibrutinib (PCI-32765), a potent inhibitor of BTK induces impressive responses in B-cell malignancies through irreversible bond with cysteine-481 in the active sit...

Novero, Aileen; Ravella, Pavan M.; Chen, Yamei; Dous, George; Liu, Delong

2014-01-01

394

Malignancy in pigmented villonodular synovitis  

International Nuclear Information System (INIS)

Malignant pigmented villonodular synovitis is an extremely rare and controversial disease. We describe malignant change in pigmented villonodular synovitis of the ankle in a patient with an unusually long clinical history. Symptoms began at age 21, metastatic disease developed at age 85, and the patient died 1 year later. The histologic appearance of the malignant tumor differed from that in most reported cases, in that spindle-shaped cells predominated. Lymph node metastasis also developed, a feature uncommon to soft tissue sarcomas. (orig.)

395

Malignant glaucoma / Glaucoma maligno  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese O objetivo deste artigo de revisão é discutir o conhecimento atual sobre a fisiopatologia e as abordagens diagnóstica, terapêutica e profilática do glaucoma maligno. Este tipo de glaucoma pode ocorrer após diferentes procedimentos cirúrgicos. Pode ocorrer em olhos áfacos, fácicos e pseudofácicos e s [...] e desenvolver espontaneamente em olhos não-operados, ou associado ao uso de mióticos. Atualmente, a biomicroscopia ultrassônica tem revelado muitos achados úteis e importantes para o diagnóstico e o tratamento do glaucoma maligno. Ele ocorre com maior frequência em olhos pequenos nos quais as medidas pré-operatórias da profundidade da câmara anterior e do comprimento axial são extremamente importantes para a sua profilaxia e diagnóstico. Abstract in english The aim of this review is to discuss current knowledge about pathophysiology and clinical, therapeutic and prophylactic approaches for malignant glaucoma. This type of glaucoma can occur after different surgical procedures. It can also occur in aphakic, phakic and pseudophakic eyes and develop spont [...] aneously in individuals with no ocular surgical history, or associated with topical miotics. Currently, the ultrasound biomicroscopy has provided many interesting and useful findings for diagnosis and monitoring the treatment of malignant glaucoma. It occurs more often in short eyes in which pre operative measurements of the anterior chamber depth and axial length are extremely important for its prophylaxis and diagnosis.

Sebastião, Cronemberger; Nassim, Calixto; Alberto, Diniz Filho.

2012-10-01

396

Malignant glaucoma Glaucoma maligno  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this review is to discuss current knowledge about pathophysiology and clinical, therapeutic and prophylactic approaches for malignant glaucoma. This type of glaucoma can occur after different surgical procedures. It can also occur in aphakic, phakic and pseudophakic eyes and develop spontaneously in individuals with no ocular surgical history, or associated with topical miotics. Currently, the ultrasound biomicroscopy has provided many interesting and useful findings for diagnosis and monitoring the treatment of malignant glaucoma. It occurs more often in short eyes in which pre operative measurements of the anterior chamber depth and axial length are extremely important for its prophylaxis and diagnosis.O objetivo deste artigo de revisão é discutir o conhecimento atual sobre a fisiopatologia e as abordagens diagnóstica, terapêutica e profilática do glaucoma maligno. Este tipo de glaucoma pode ocorrer após diferentes procedimentos cirúrgicos. Pode ocorrer em olhos áfacos, fácicos e pseudofácicos e se desenvolver espontaneamente em olhos não-operados, ou associado ao uso de mióticos. Atualmente, a biomicroscopia ultrassônica tem revelado muitos achados úteis e importantes para o diagnóstico e o tratamento do glaucoma maligno. Ele ocorre com maior frequência em olhos pequenos nos quais as medidas pré-operatórias da profundidade da câmara anterior e do comprimento axial são extremamente importantes para a sua profilaxia e diagnóstico.

Sebastião Cronemberger

2012-10-01

397

Rapid Biodiesel Fuel Production Using Novel Fibrous Catalyst Synthesized by Radiation-Induced Graft Polymerization  

Directory of Open Access Journals (Sweden)

Full Text Available An efficient fibrous catalyst for the biodiesel fuel production has been synthesized by radiation-induced graft polymerization of 4-chloromethylstyrene onto a nonwoven polyethylene (NWPE fabric followed by amination with trimethylamine (TMA and further treatment with NaOH. The degree of grafting of NWPE fabric and TMA group density of fibrous catalyst could easily and reproducibly be controlled within a range of up to 340% and 3.6 mmol-TMA/g-catalyst, respectively. In the transesterification of triglycerides and ethanol using the synthesized fibrous catalyst, the conversion ratio of triglycerides reached 95% after 4 h reaction at 50°C.

Nor Hasimah Mohamed

2011-05-01

398

Stromal, Fibrous, and Fatty Gastrointestinal Tumors Associated With A PDGFRA Gene Mutation  

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We report the case of a woman with 3 different types of gastrointestinal tumors—stromal, fibrous, and fatty—and a germline defect of the PDGFRA gene (V561D). The patient, now 52 years old, presented in 1977 at age 22 years with a gastric tumor and a duodenal lipoma. Subsequently, she developed KIT-negative, CD34-positive obstructing small intestinal fibrous tumors that required three laparotomies and intestinal resections. Most recently (in 2002), more than 100 of the fibrous tumors were ...

Carney, J. Aidan; Stratakis, Constantine A.

2008-01-01

399

A large infiltrating fibrous hamartoma of infancy in the abdominal wall with rare associated tuberous sclerosis  

International Nuclear Information System (INIS)

Tuberous sclerosis is a complex autosomal-dominant neurocutaneous syndrome characterized by hamartomatous malformations of fibrous and connective tissues in various organs. Although various histologic types of soft-tissue masses can occur with tuberous sclerosis, we present a unique case of fibrous hamartoma of infancy presenting as large infiltrating cutaneous and subcutaneous masses in the abdominal wall in a 4-year-old boy with tuberous sclerosis. Although the co-occurrence of tuberous sclerosis and fibrous hamartoma of infancy is very rare, it should be considered in the differential diagnosis of subcutaneous soft-tissue masses found in children with tuberous sclerosis. (orig.)

400

Effect of Fibrous Concrete Layers on Behavior of Self-Compacting Concrete Slabs under Uniform Load  

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This research study the effect of using fibrous concrete layers on behavior of two way Self-Compacting Concrete slabs with ratio (length/width) ?1.618 [golden ratio] using steel fiber. The experimental work can be divided in two groups, each group having steel fiber–volume fractions of 0.4% and 0.8%, moreover both groups having two concrete slabs one with two fibrous layers (bottom + top) and the other with one fibrous layer (bottom), in additional to concrete slab without...

Al-ridha, Dr Ahmed S. D.

2014-01-01

 
 
 
 
401

CT findings of retroperitoneal masses  

International Nuclear Information System (INIS)

Retrospective analysis of forty one retroperitoneal masses was made with computed tomography. All cases were confirmed pathologically by operation or needle aspiration biopsy. The cases were; 14 abscesses, 2 leiomyosarcomas, 2 rhabdomyosarcomas, 2 liposarcomas, 1 undifferentiated sarcoma, 3 endodermal sinus tumors, 4 teratomas, 2 neurofibromas, 1 neurilemoma, 3 neuroblastomas, 4 malignant lymphomas, 2 malignant fibrous histiocytomas and 1 hemangiopericytoma. Tumors originated from urinary tract and pancreas were not included. Findings favor tumor rather than inflammation were; large lobulated soft tissue mass with eccentric or heterogeneous low density, thick cavity wall, disruption of fascial planes, regional lymphnode enlargement and distant metastasis

402

A case of dedifferentiated liposarcoma showing a biphasic pattern on 2-deoxy-2-F18- fluoro-D-glucose positron emission tomography/ computed tomography  

Directory of Open Access Journals (Sweden)

Full Text Available Integrated 2-deoxy-2-F18-fluoro-D-glucose positron emission tomography combined with computed tomography (FDG-PET/CT has been used in the field of soft tissue sarcoma. We report an 81-year-old man with dedifferentiated liposarcoma in the left thigh, which was composed of well-differentiated liposarcoma and pleomorphic malignant fibrous histiocytoma. As well as other radiological modalities, FDG-PET was able to demonstrate a biphasic signal pattern composed of well-differentiated liposarcoma and dedifferentiated area, being consistent with the histological grade of malignancy.

Manabu Hoshi

2013-04-01

403

Uncommon breast lesions. Radiologic and pathologic findings  

International Nuclear Information System (INIS)

To illustrate the radiologic findings in several uncommon breast and infrequent diseases that present with unusual mammographic images. We reviewed the mammograms performed in our department between 1998 and 1995, selecting 16 patients (12 women and 4 men). Nine patients had benign breast lesions (adenomyoepithelioma, epidermal cyst, adenoid cystic carcinoma, myofibroblastoma, multiple hamartomas, intra cystic papillomas, lipoma, idiopathic granulomatous mastitis and fat necrosis) and 7 patients presented malignant breast diseases (malignant fibrous histiocytoma, intra cystic carcinoma, primary lymphoma of the breast, liposarcoma and metastasis). We present a review of the radiologic and pathologic findings in several uncommon breast diseases. (Author) 14 refs

404

Diffuse Increased FDG Uptake in the Bone Marrow due to Leukemoid Reaction  

Directory of Open Access Journals (Sweden)

Full Text Available PET-CT scan showed diffuse increased FDG uptake in the bone marrow in patient with  pulmonary malignant fibrous histiocytoma who was referred to our clinic for preoperative staging. Recent chemotheraphy treatment, granulocyte colony-stimulating factor using was not there on patients medical history. Total leukocyte count was 51800/?L, with 92.1 % neutrophils, 0.7 % eosinophils, 4.3 %  lymphocytes, and 2.8 % monocytes. Bone marrow biopsy was revealed a hypercellular marrow with no evidence of malignancy. It was diagnosed that diffuse bone marrow FDG uptake in our patient was due to leukemoid reaction.

Celal Tekinba?

2012-01-01

405

Primary mesenchymal liver tumors: radiological spectrum, differential diagnosis, and pathologic correlation.  

Science.gov (United States)

With the exception of hemangioma, benign or malignant primary mesenchymal tumors of the liver are seldom encountered. The aim of this review was to discuss the clinical, histopathological, and imaging features of liver hemangiomas (cavernous, capillary, and sclerosed types), liver lipoma, angiomyolipoma, mesenchymal hamartoma, neurofibroma, infantile hemangioendothelioma, epithelioid hemangioendothelioma, myofibroblastoma, angiosarcoma, malignant fibrous histiocytoma, undifferentiated embryonal sarcoma, and nested stromal tumor. In most of these rare liver tumors, radiological findings obtained by cross-sectional imaging may reflect the characteristic pathologic features required for differential diagnosis; however, definitive diagnosis should be confirmed using histopathological examination. PMID:25311993

Harman, Mustafa; Nart, Deniz; Acar, Türker; Elmas, Nevra

2014-10-14

406

Treatment of thyroid malignancies  

International Nuclear Information System (INIS)

Clinically significant thyroid malignancies are relatively uncommon, although their prevalence in autopsy series ranges up to 11%. New data confirm an increased incidence of carcinoma in solitary thyroid nodules in younger patients and a greater likelihood for younger patients to present with metastatic disease. Treatment of differentiated thyroid carcinoma is controversial, although many series indicate excellent results with total thyroidectomy. Although iodine-131 ablation has been standard in most centers after total thyroidectomy when residual thyroid tissues are present, new data indicate that selective use of this therapy may be appropriate. Prophylactic neck dissection dose not improve survival or lessen recurrence in differentiated thyroid cancers and may increase morbidity. It should, therefore, be reserved for the patient with clinically enlarged cervical nodes.141 references

407

Malign retroperitoneal schwannoma  

International Nuclear Information System (INIS)

The retroperitoneal tumors are infrequent and are classified according to the original tissue. This is a case presentation of a patient presenting with pain in right hypochondrium and a tumor in this zone, weight loss and painful discomfort in the anterolateral face of right thigh. In physical examination we found cutaneousmucous paleness and painless tumor in hypochondrium and right flank. Abdominal ultrasound (US) showed a homogenous mass of 14,11 cm and abdominal computed tomography allows to see a right retroperitoneal tumor rejecting the kidney. Excretory urogram showed a anteromedial rejection of right kidney. An encapsulated tumor with a few peritumoral adherences was removed. By histological study it was possible to confirm a fusiform cells tumor with hyperchromatism and nuclear pleomorphism, numerous mitosis and areas of necrosis and in the diagnosis of malign tumor of the sheath of a peripheral nerve.(author)

408

Hypercalcemia in malignant disease.  

Science.gov (United States)

Hypercalcemia is a common and serious complication of neoplastic disease. It may occur in association with a variety of tumors and usually indicates a lack of tumor control. Early symptoms are nonspecific, involving several organ systems in a syndrome that may progress rapidly to death. The pathophysiology of hypercalcemia is complex and not fully understood. Research continues on local mechanisms of bone destruction at sites of bone metastases and the identification of humoral tumor-derived osteolytic factors. The therapeutic approach to hypercalcemia should be sequential, dictated more by clinical symptoms than by absolute calcium levels. The diversity of measures and agents used in the therapy of hypercalcemia of malignancy reflects the multiple mechanisms involved. The therapeutic maneuvers outlined usually yield temporary success and must be accompanied by specific antitumor therapy, the ultimate treatment for the hypercalcemia of neoplastic disease. PMID:6760966

Hanagan, J R

1982-01-01

409

Supratentorial malignant glioma  

International Nuclear Information System (INIS)

To analyze treatments of supratentorial malignant gliomas in the megavoltage era, all the histologic specimens were reviewed and glioblastoma multiforme (GBM) was distuished from anaplastic astrocytoma (AA) by the presence of nectosis. Among those who had completed radiotherapy and who had been followed for at least one year, 135 GBM and 43 AA patients were found. The median survival time (MST) after operation was 12 months for GBM and 18 months for AA. The 5-year survival rate was 0.9% for GBM and 18% for AA. The size of radiation field had little influence on survival time; MST was 12 months for those treated with a generous field (2 cm or more margin), and 13 months for those treated to whole brain. Also for AA, whole brain radiation did not prolong survival. Initial relapse of GBM and AA developed within the irradiated volume in 86% of the cases treated with a generous field. Whole brain radiation seemed useless for the treatment of malignant gliomas. Survival time appeared to be dose-dependent; MST was 10, 13, and 16 months for GBM patients who received 45-57, 57-63, and 63-72 Gy, respectively. Extensive surgical resection was associated with a better prognosis in GBM. AA patients 60 years old or older had a poorer prognosis than younger patients, but age was not a significant prognostic factor for GBM. Chemotherapy appeared to prolong survival slightly without improving long-term survival. Currently, an accelerated hyperfractionation regimen is being tested in wfractionation regimen is being tested in which 1.5 Gy is given twice a day up to 69 Gy. Preliminarily, this regimen had no acute or late toxicity and yielded a survival rate at least equivalent to the conventional regimen. (author). 37 refs.; 6 figs.; 4 tabs

410

Primary intracranial malignant lymphoma  

International Nuclear Information System (INIS)

Nine cases of primary intracranial malignant lymphoma, which accounts for 3.3 % of all intracranial tumors seen in the authors' institution, were studied in terms of diagnostic computed tomographic (CT) features, the tumors' histologic appearance, treatment, post-treatment blood immunologic and cerebrospinal fluid (CSF) characteristics, and outcome. The patients were seven males and two females aged 42 to 67 years. Their chief signs and symptoms on admission were intracranial hypertension, focal signs, and disturbance of consciousness. CT, which proved the most useful preoperative diagnostic technique, demonstrated multiple lesions in seven cases and, in all cases, regions of isodensity or slight high density that were enhanced by contrast medium. According to the patterns of enhancement, the tumors were classed as diffuse (three cases) or nodular (six cases). The former is considered typical of malignant lymphoma, whereas the latter type was sometimes indistinguishable from metastatic tumor and meningioma. At surgery, one patient underwent radical tumor excision, two partial removal, and six biopsy only. Histologic examination revealed one tumor to be of the diffuse small cell type, three of the medium cell type, and five of the large cell type (Lymphoma Study Group classification). Of seven tumors in which lymphocytes were examined by peroxidase-antiperoxidase staining, four were of the B cell type. Postoperatively, whole brain irradiation with 29 to 46 Gy was folloain irradiation with 29 to 46 Gy was followed by local irradiation with 15 to 50 Gy. If the tumor persisted, one of three chemotherapies was administered. In one case, methotrexate was given intrathecally. Seven patients were divided into two groups: long remission (three) and recurrence (four). These two groups were compared in terms of serum immunoglobulin levels, T and B cell ratios, CSF characteristics, CT features, tumor cell type, and treatment. No clear differences were found. (author)

411

Radiotherapy of choroidal malignant melanomas  

Energy Technology Data Exchange (ETDEWEB)

Choroidal malignant melanomas are relatively rare tumours and can have a very long natural history. The management of these tumours is controversial. The results of a study of a small group of patients treated by radiotherapy, either as primary treatment or following local excision or enucleation, are presented here. The value of radical radiotherapy in the management of choroidal malignant melanoma is discussed.

Ammar, F.; Robertson, A.G.; Dudgeon, J.

1987-01-01

412

Hematologic malignancies of the pancreas.  

Science.gov (United States)

Hematologic malignancies are relatively uncommon neoplasms of abdominal soft tissue. This article discusses the clinical and imaging features of pancreatic lymphoma, pancreatic extraosseous multiple myeloma, granulocytic sarcoma (chloroma), posttransplant lymphoproliferative disorder, and Castleman disease. The combination of imaging findings and the appropriate clinical presentation should allow the radiologist to raise a provisional diagnosis of hematologic malignancy. PMID:25120155

Sandrasegaran, Kumar; Tomasian, Anderanik; Elsayes, Khaled M; Nageswaran, Harris; Shaaban, Akram; Shanbhogue, Alampady; Menias, Christine O

2015-02-01

413

Primary malignant melanoma of prostate  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Primary genitourinary melanoma accounts for less than one per cent of all cases of melanoma. Most cases attributed to the prostate actually originate from the prostatic urethra. Due to its infrequency, primary malignant melanoma of the genitourinary tract presents a difficult diagnostic and management challenge. We report a case of primary malignant melanoma of the prostate found during transurethral resection of the prostate.

Doublali M; Chouaib A; Khallouk A; Tazi M; El Fassi M; Farih My; Elfatmi H; Bendahou M; Benlemlih A; Lamarti O

2010-01-01

414

Assessment of fibrous insulation materials for the selenide isotope generator system  

International Nuclear Information System (INIS)

Fibrous insulations for use in the converter and the heat source of the radioisotope-powered, selenide element, thermoelectric generator (selenide isotope generator) are assessed. The most recent system design and material selection basis is presented. Several fibrous insulation materials which have the potential for use as load-bearing or nonload-bearing thermal insulations are reviewed, and thermophysical properties supplied by manufacturers or published in the literature are presented. Potential problems with the application of fibrous insulations in the selenide isotope generator are as follows: compatibility with graphite, the thermoelectric elements, and the isolation hot frame; devitrification, grain growth, and sintering with an accompanying degradation of insulation quality; impurity diffusion from the insulation to adjoining structures; outgassing and storage of fibrous materials. Areas in which thermophysical data or quantitative information on the insulation and structural stability is lacking are identified

415

Case report 207: Giant cell reparative granuloma of left femur arising in polyostatic fibrous dysplasia  

International Nuclear Information System (INIS)

Diagnosis and differential diagnosis of lytic lesions in the femur are discussed. Roentgenograms, a tomogram and pathological studies of a giant cell reparative granuloma of left femur arising in polyostotic fibrous dysplasia are presented. (WU)

416

RECEPTION OF NANOPARTICLES OF SILVER FOR USE IN MANUFACTURE OF FIBROUS COVERS ????????? ?????????? ??????? ??? ????????????? ? ???????????? ?????????? ????????  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Results of deep comprehensive investigation of possibility of a method of micellar colloidal synthesis for reception nanoparticles of silver with the set characteristics are evaluated. The production technology of fibrous covers with nanoparticles of silver is considered

Gorlov I. F.; Ananyan M. A.; Chmulev I. S.

2012-01-01

417

Solitary fibrous tumor of the male breast: a case report and review of the literature  

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Abstract Extrapleural solitary fibrous tumors are very rare and occasionally they appear in extraserosal soft tissues or parenchymatous organs. In such cases the right preoperative diagnosis is often difficult and challenging, because both radiological and cytological examinations are not exhaustive. For these reasons, surgical excision is frequently the only way to reach the correct diagnosis and to achieve definitive treatment. A few cases of solitary fibrous tumors have been also...

Sessa Fausto; La Rosa Stefano; Marelli Marina; Limonta Giorgio; Imbriglio Giovanna; Rovera Francesca; Dionigi Gianlorenzo; Boni Luigi; Dionigi Renzo

2008-01-01

418

Liquid perfluorochemical-supported hybrid cell culture system for proliferation of chondrocytes on fibrous polylactide scaffolds  

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CP5 bovine chondrocytes were cultured on biodegradable electrospun fibrous polylactide (PLA) scaffolds placed on a flexible interface formed between two immiscible liquid phases: (1) hydrophobic perfluorochemical (PFC) and (2) aqueous culture medium, as a new way of cartilage implant development. Robust and intensive growth of CP5 cells was achieved in our hybrid liquid–solid–liquid culture system consisting of the fibrous PLA scaffolds in contrast to limited growth of the CP5 cells in tr...

Pilarek, Maciej; Grabowska, Iwona; Senderek, Ilona; Wojasin?ski, Micha?; Janicka, Justyna; Janczyk-ilach, Katarzyna; Ciach, Tomasz

2014-01-01

419

Case report: Calcifying fibrous tumor presenting as an asymptomatic pelvic mass  

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Calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor most commonly found in the soft tissues of the extremities and pleura. It is characterized by hyalinized collagenous fibrous tissue, with bland spindle cells, psammomatous or dystrophic calcifications, and focal lymphoplasmacytic infiltrate. CFT of the gastrointestinal tract is exceedingly uncommon. We report a case of CFT arising from the small intestine and associated mesentery; this case was identified incidentally in an oth...

Giardino, Angela A.; Ramaiya, Nikhil H.; Shinagare, Atul B.; Jagannathan, Jyothi P.; Stachler, Matthew D.; Raut, Chandrajit P.

2011-01-01

420

Electrospinning of fibrous polymer scaffolds using positive voltage or negative voltage: A comparative study  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Electrospinning of fibrous tissue engineering scaffolds has been traditionally conducted using positive voltages. In the current study, positive voltage (PV) electrospinning and negative voltage (NV) electrospinning were investigated for forming fibrous membranes of poly(hydroxybutyrate-co- hydroxyvalerate) (PHBV). In both PV-electrospinning and NV-electrospinning, the fiber diameter generally increased with increasing needle inner diameter and PHBV concentration but decreased with increasing...

Wang, M.; Tong, Hw

2010-01-01

 
 
 
 
421

Thoracic Outlet Syndrome Caused by Fibrous Dysplasia of the First Rib  

Science.gov (United States)

Fibrous dysplasia causing thoracic outlet syndrome is rare. A 41-year-old woman presented with neurogenic thoracic outlet syndrome with imaging that demonstrated a large tumor of her proximal left first rib. Transaxillary excision was unsuccessful due to involvement of the subclavian vasculature and brachial plexus. Subsequent posterolateral thoracotomy and resection of her first rib revealed fibrous dysplasia. Thoracotomy should be considered in these cases for optimal vascular control and identification of thoracic outlet anatomy. PMID:22364999

Kemp, Clinton D.; Rushing, Gregory D.; Rodic, Nemanja; McCarthy, Edward; Yang, Stephen C.

2013-01-01

422

Tumor fibroso solitario pleural de lenta evolución / Giant solitary fibrous tumour of the pleura of slow evolution  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish El tumor fibroso solitario pleural es una neoplasia infrecuente originada en las células submesoteliales de la superficie pleural. Generalmente se manifiesta como una masa exofítica que crece hacia dicho espacio comprimiendo estructuras adyacentes. Su diferencia con el mesotelioma pleural maligno no [...] sólo yace en su origen histológico, sino también en los antecedentes epidemiológicos y el curso clínico de la enfermedad. Presentamos el caso de un paciente con una masa pleural gigante de 11 años de evolución, los inconvenientes suscitados con el diagnóstico y, finalmente, la resolución quirúrgica definitiva. Abstract in english The solitary fibrous tumor of the pleura is a rare neoplasm originating from submesothelial cells of the pleural membrane. Its usual manifestation is as an exophytic mass that grows into the pleural cavity compressing adjacent structures. The difference with malignant pleural mesothelioma does not o [...] nly lie in its histological origin, but also in the epidemiological history and clinical course of the disease. We report a patient with a giant pleural mass of 11 years of evolution, the problems arising for the diagnosis, and finally the definitive surgical treatment.

Ana Karina, Patané; Mercedes, Rayá; Adolfo, Rosales; Hector, Rivero; Oscar, Rojas.

2012-12-01

423

Nanoscale dynamics and aging of fibrous peptide-based gels  

Science.gov (United States)

Solutions of the aromatic dipeptide derivative molecule fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) in dimethyl sulfoxide produce fibrous gels when mixed with water. We study the evolution of density fluctuations of this three-component system using X-ray photon correlation spectroscopy (XPCS) and compare these results to the macroscopic rheology of the gels and optical observations of the microstructure evolution. At the investigated scattering angles, the intensity autocorrelation functions do not follow behavior expected for simple diffusion of individual Fmoc-FF molecules localized within cages of nearest neighbors. Instead, the dynamics are associated with density fluctuations on length scales of ˜10-100 nm arising from disaggregation and reformation of fibers, leading to an increasingly uniform network. This process is correlated with the growth of the elastic modulus, which saturates at long times. Autocorrelation functions and relaxation times acquired from XPCS measurements are consistent with relaxation rates of structures at dynamic equilibrium. This study provides further support to the concept of exploring peptide-based gelators as valence-limited patchy particles capable of forming equilibrium gels.

Dudukovic, Nikola A.; Zukoski, Charles F.

2014-10-01

424

FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY  

Energy Technology Data Exchange (ETDEWEB)

During this reporting period, work continued on development of formulations using the materials identified as contenders for the fibrous monolith wear resistant components. The FM structures fabricated were: diamond/WC-Co, B{sub 4}C/WC-Co, TiB{sub 2}/WC-Co, WC-Co/Co, WC-Co/WC-Co. Results of our consolidation densification studies on these systems lead to the down-selection of WC-Co/WC-Co, WC-Co/Co and diamond/WC-Co for further development for mining applications including drill bit inserts, roof bit inserts, radial tools conical tools and wear plates (WC-Co based system only) for earth moving equipment. Prototype component fabrication focused on the fabrication of WC-Co/WC-Co FM conical tools, diamond/WC-Co coated drill bit insert prototypes. Fabrication of WC-Co/WC-Co FM insert prototypes for a grader blade is also underway. ACR plans to initiate field-testing of the drill bit insert prototypes and the grader blade insert this summer (2002). The first WC-Co/WC-Co FM conical tool prototypes were sent to Kennametal for evaluation towards the end of the current reporting period.

Mark J. Rigali; Kenneth L. Knittel; Mike L. Fulcher

2002-03-01

425

Rapid reconstruction of 3D structure of fibrous media  

CERN Document Server

Characterization of transport properties of porous media is increasingly relying on computational methods that require reconstruction of the media structure. We present a simple method of constructing the 3D surface of fibrous porous media - the gas diffusion layer (GDL) used as the porous electrode in PEM fuel cells. The method is based on extending the depth-of-field on the whole attainable thickness of the GDL. A series of images of the GDL sample is recorded by the sequential movement of the sample with respect to the microscope focus. Different layers of the surface of the sample appear in focus in the different images in the series. The indexed series of the in-focus portions of the sample surface is combined into one sharp 2D image and interpolated into the 3D surface representing the surface of an original GDL sample. The method uses a conventional upright stage microscope that is operated manually, the inexpensive Helicon Focus software, and the open source MeshLab software. The accuracy of the recon...

Berejnov, Viatcheslav; Djilali, Ned

2009-01-01

426

Sperm protein 17 is expressed in the sperm fibrous sheath  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Sperm protein 17 (Sp17 is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues. It was also recognized in two myeloma cell lines and in neoplastic cells from patients with multiple myeloma and ovarian carcinoma. These data all indicate that Sp17 is widely distributed in humans, expressed not only in germinal cells and in a variety of somatic tissues, but also in neoplastic cells of unrelated origin. Methods Sp17 expression was analyzed by immunocytochemistry and transmission electron microscopy on spermatozoa. Results Here, we demonstrate the ultrastructural localization of human Sp17 throughout the spermatozoa flagellar fibrous sheath, and its presence in spermatozoa during in vitro states from their ejaculation to the oocyte fertilization. Conclusion These findings suggest a possible role of Sp17 in regulating sperm maturation, capacitation, acrosomal reaction and interactions with the oocyte zona pellucida during the fertilization process. Further, the high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP-binding motif within this region, suggest that Sp17 might play a regulatory role in a protein kinase A-independent AKAP complex in both germinal and somatic cells.

Albani Elena

2009-07-01

427

Effective property of multiferroic fibrous composites with imperfect interfaces  

International Nuclear Information System (INIS)

This paper studies the effective behavior of piezoelectric and piezomagnetic circular fibrous composites with imperfect interfaces under longitudinal shear with in-plane electromagnetic fields. Two kinds of imperfect contact are investigated: mechanically stiff and dielectrically/magnetically highly conducting interfaces, and mechanically compliant and dielectrically/magnetically weakly conducting interfaces. For the former case, the potential field is continuous, while the normal component of the flux undergoes a discontinuity across the interface. For the latter case, the normal component of the flux is continuous, while there is a jump of potential field at such a contact. The classic work of Rayleigh (1892 Phil. Mag. 34 481–502) in a periodic conductive perfect composite is generalized to the current coupled magnetoelectroelastic composites with imperfect interfaces. It is shown that the expression of the effective property has exactly the same form as that in the ideal coupling composite. Finally, this method is used to study BaTiO3–CoFe2O4 composites and provide insights into enhancing the effective magnetoelectric voltage coefficient by properly choosing the interface. (paper)

428

Effective property of multiferroic fibrous composites with imperfect interfaces  

Science.gov (United States)

This paper studies the effective behavior of piezoelectric and piezomagnetic circular fibrous composites with imperfect interfaces under longitudinal shear with in-plane electromagnetic fields. Two kinds of imperfect contact are investigated: mechanically stiff and dielectrically/magnetically highly conducting interfaces, and mechanically compliant and dielectrically/magnetically weakly conducting interfaces. For the former case, the potential field is continuous, while the normal component of the flux undergoes a discontinuity across the interface. For the latter case, the normal component of the flux is continuous, while there is a jump of potential field at such a contact. The classic work of Rayleigh (1892 Phil. Mag. 34 481-502) in a periodic conductive perfect composite is generalized to the current coupled magnetoelectroelastic composites with imperfect interfaces. It is shown that the expression of the effective property has exactly the same form as that in the ideal coupling composite. Finally, this method is used to study BaTiO3-CoFe2O4 composites and provide insights into enhancing the effective magnetoelectric voltage coefficient by properly choosing the interface.

Kuo, Hsin-Yi

2013-10-01

429

A Study of Failure Criteria of Fibrous Composite Materials  

Science.gov (United States)

The research described in this paper is focused on two areas: (1) evaluation of existing composite failure criteria in the nonlinear, explicit transient dynamic finite element code, MSC.Dytran, and (2) exploration of the possibilities for modification of material and failure models to account for large deformations, progressive failure, and interaction of damage accumulation with stress/strain response of laminated composites. Following a review of the MSC.Dytran user manual, a bibliographical review of existing failure criteria of composites was performed. The papers considered most interesting for the objective of this report are discussed in section 2. The failure criteria included in the code under consideration are discussed in section 3. A critical summary of the present procedures to perform analysis and design of composites is presented in section 4. A study of the most important historical failure criteria for fibrous composite materials and some of the more recent modifications proposed were studied. The result of this analysis highlighted inadequacies in the existing failure criteria and the need to perform some numerical analyses to elucidate the answer to questions on which some of the proposed criteria are based. A summary of these ideas, which is a proposal of studies to be developed, is presented in section 5. Finally, some ideas for future developments are summarized in section 6.

Paris, Federico; Jackson, Karen E. (Technical Monitor)

2001-01-01

430

FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY; SEMIANNUAL  

International Nuclear Information System (INIS)

During this reporting period, work continued on development of formulations using the materials identified as contenders for the fibrous monolith wear resistant components. The FM structures fabricated were: diamond/WC-Co, B(sub 4)C/WC-Co, TiB(sub 2)/WC-Co, WC-Co/Co, WC-Co/WC-Co. Results of our consolidation densification studies on these systems lead to the down-selection of WC-Co/WC-Co, WC-Co/Co and diamond/WC-Co for further development for mining applications including drill bit inserts, roof bit inserts, radial tools conical tools and wear plates (WC-Co based system only) for earth moving equipment. Prototype component fabrication focused on the fabrication of WC-Co/WC-Co FM conical tools, diamond/WC-Co coated drill bit insert prototypes. Fabrication of WC-Co/WC-Co FM insert prototypes for a grader blade is also underway. ACR plans to initiate field-testing of the drill bit insert prototypes and the grader blade insert this summer (2002). The first WC-Co/WC-Co FM conical tool prototypes were sent to Kennametal for evaluation towards the end of the current reporting period

431

FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY  

Energy Technology Data Exchange (ETDEWEB)

During the reporting period, work continued on development of formulations using the materials down-selected from the initially identified contenders for the fibrous monolith wear resistant components. The FM systems studied were: WC-Co/WC-Co, WC-Co/Co, diamond/WC-Co, and Al{sub 2}O{sub 3}/Al{sub 2}O{sub 3}-TiCN. Extrudable formulations for the materials listed were developed during the first twelve months of this effort, and work during the reporting period was focused on the development of optimized binder removal processes. A two stage binder removal process was developed that resulted in prototype parts free of voids and other internal defects. In addition, changes in the binder removal atmosphere resulted in the apparent elimination of residual carbon, an important consideration when consolidating WC-Co containing systems. Using the improved binder removal processes, parts were consolidated by both sintering and hot pressing to >99% theoretical density. Samples of these materials were sent to Kyocera for mechanical evaluations. Fabrication of drill bit inserts was begun, and binder removal begun during the reporting period. A total of 24 green inserts were fabricated, and will be consolidated and delivered for field testing during the upcoming reporting period.

Mark J. Rigali; Mike L. Fulcher; Kenneth L. Knittel

2002-10-01

432

Optimization of Grafted Fibrous Polymer as a Solid Basic Catalyst for Biodiesel Fuel Production  

Directory of Open Access Journals (Sweden)

Full Text Available Grafted fibrous polymer with quaternary amine groups could function as a highly-efficient catalyst for biodiesel fuel (BDF production. In this study, the optimization of grafted fibrous polymer (catalyst and transesterification conditions for the effective BDF production was attempted through a batch-wise transesterification of triglyceride (TG with ethanol (EtOH in the presence of a cosolvent. Trimethylamine was the optimal quaternary amine group for the grafted fibrous catalyst. The optimal degree of grafting of the grafted fibrous catalyst was greater than 170%. The optimal transesterification conditions were as follows: The optimal molar quantity of quaternary amine groups, transesterification temperature, molar ratio of TG and EtOH, and primary alkyl alcohol were 0.8 mmol, 80°C, 1:200, and 1-pentanol, respectively. The grafted fibrous catalyst could be applied to BDF production using natural oils. Furthermore, the grafted fibrous catalyst could be used repeatedly after regeneration involving three sequential processes, i.e., organic acid, alkali, and alcohol treatments, without any significant loss of catalytic activity.

Yuji Ueki

2014-05-01

433

IL-8 response of cyclically stretching alveolar epithelial cells exposed to non-fibrous particles.  

Science.gov (United States)

Using a cell stretcher device, we have previously shown that A549 cells exposed to asbestos fibers gave significantly increased cytokine responses (IL-8) when they were cyclically stretched [Tsuda, A., B. K. Stringer, S. M. Mijailovich, R. A. Rogers, K. Hamada, and M. L. Gray. Am. J. Respir. Cell Mol. Biol. 21(4):455-462, 1999]. In the present study, cell stretching experiments were performed using non-fibrous riebeckite particles, instead of fibrous particles. Riebeckite particles are ground asbestos fibers with the size of a few microns and non-fibrous shape, and are often used as "non-toxic" control particles in the studies of fibrous particle-induced pathogenesis. Although it is generally assumed that riebeckite particles do not elicit strong biological responses, in our studies in cyclically stretched cell cultures, the riebeckite particles coated with adhesion proteins induced significant IL-8 responses, but in static cell cultures the treatment with adhesion protein-coated riebeckite did not induce comparable cytokine responses. To interpret these data, we have developed a simple mathematical model of adhesive interactions between a cell layer and rigid fibrous/non-fibrous particles that were subjected to external tensile forces. The analysis showed that because of considerable dissimilarity in deformations (i.e., strain mismatch) between the cells and particles during breathing, the attachment of particles as small as 1 micro in size could induce significant mechanical forces on the cell surface receptors, which may trigger subsequent adverse cell response under dynamic stretching conditions. PMID:17242997

Mijailovich, S M; Hamada, K; Tsuda, A

2007-04-01

434

RARE METASTASES OF MALIGNANT MELANOMA  

Directory of Open Access Journals (Sweden)

Full Text Available Melanomas are malignant neoplasms that originate from melanocytes. The most common are on the skin and mucous membranes. Choroidal melanomas are quite different from cutaneous melanomas with regard to presentation, metastases, and treatment. We report two cases of metastatic gastric malignant melanoma of the eye and skin, with reference to the literature. The first patient was a woman aged 23 years, who underwent gastrectomy 22 months after enucleation of the eye due to malignant choroid melanoma. The second patient was a man, 72 years old, who underwent surgery 28 months before because of malignant melanoma of the skin of the forehead. Paraffin sections, 4 ?m thick were stained using a classic method, as well as immunohistochemical DAKO APAAP method, using a specific S - 100 antibody and Melan A antibodies. The stomach is considered a rare place for the development of metastases. Metastases in the stomach are often limited to the submucosal as well as the serousmuscular layer, as noted in one of our patients. Metastatic melanoma of the gastrointestinal tract should be suspected in any patient with a history of malignant melanoma and new gastrointestinal symptoms. Because of the similarity between certain common histopathological types of malignant melanoma, primarily achromatic, and types of primary cancers of the stomach, the following immunohistochemical studies are needed: Melan A and S - 100 protein ( markers of malignant melanoma , as well as mucins: MUC5AC, MUC2 and CDX2 ( markers of different types of primary gastric carcinoma.

Marija Trenki?-Božinovi?

2014-09-01

435

Occupational exposure and malignant lymphoma.  

Science.gov (United States)

The incidence of malignant lymphoma, especially non-Hodgkin's lymphoma has increased over the last few decades. This statement is true despite the fact that methods for diagnosing malignant lymphoma have changed and misclassification has become a problem. The present review is mainly concerned with occupational aspects of malignant lymphoma. Several subsequent studies have dealt with malignant lymphoma among woodworkers and pulp and paper mill workers pointing to increased risks. Exposure to phenoxy herbicides have provided reasonable evidence to be connected with an increased risk of non-Hodgkin's lymphoma, whereas there is limited information regarding Hodgkin's disease. The relationship between solvent exposure and malignant lymphoma has been observed in a great number of studies. It is, however, still hard to identify specific solvent compounds responsible for the increased risk. Other occupational exposures i.e. wood preservatives, welding, asbestos, hair dyes and exposure to animal viruses among meatworkers and veterinarians have also been studied in relation to malignant lymphoma. This review shows that occupational factors, especially exposure to solvents and phenoxy herbicides and also to wood, play a role in the epidemiology of malignant lymphoma. PMID:9117190

Persson, B

1996-01-01

436

The differentiation of malignant and benign musculoskeletal tumors by F-18 FDG PET/CT studies-determination of maxSUV by analysis of ROC curve  

International Nuclear Information System (INIS)

We evaluated the standard uptake value (SUV) of F-18 FDG at PET/CT for differentiation of benign from malignant tumor in primary musculoskeletal tumors. Forty-six tumors (11 benign and 12 malignant soft tissue tumors, 9 benign and 14 malignant bone tumors) were examined with F-18 FDG PET/CT (Discovery ST, GE) prior to tissue diagnosis. The maxSUV(maximum value of SUV) were calculated and compared between benign and malignant lesions. The lesion analysis was based on the transverse whole body image. The maxSUV with cutoff of 4.1 was used in distinguishing benign from malignant soft tissue tumor and 3.05 was used in bone tumor by ROC curve. There was a statistically significant difference in maxSUV between benign (n = 11; maxSUV 3.4 ± 3.2) and malignant (n = 12; maxSUV 14.8 ± 12.2) lesion in soft tissue tumor (? = 0.001). Between benign bone tumor (n = 9; maxSUV 5.4 ± 4.0) and malignant bone tumor (n = 14; maxSUV 7.3 ± 3.2), there was not a significant difference in maxSUV. The sensitivity and specificity for differentiating malignant from benign soft tissue tumor was 83% and 91%, respectively. There were four false positive malignant bone tumor cases to include fibrous dysplasia, Langerhans-cell histiocytosis (n = 2) and osteoid osteoma. Also, one false positive case of malignant soft tissue tumor was nodular fasciitis. The maxSUV was useful for differentiation of benign from malignant lesion in primary soft tissue tumors. In bone tumor, the low maxSUV correlated one tumor, the low maxSUV correlated well with benign lesions but high maxSUV did not always mean malignancy

437

Intracavitary therapeutics for pleural malignancies.  

Science.gov (United States)

Pleural malignancies are ideal for novel therapeutic approaches because they are invariably fatal. Intrapleural (IP) chemotherapy has only marginal benefit in pleural malignancies, but may prove efficacious with hyperthermic chemotherapy administered in combination with maximal tumor debulking. IP immunotherapies may be most effective in those patients with early-stage pleural malignancy, and may prove superior to standard pleurodesis methods in control of effusion and prolongation of survival. Immunogene therapy may be unable to successfully treat bulky tumors on its own, but success may be achieved with combination approaches that combine debulking surgery and chemotherapy with IP genetic immunotherapy. PMID:23993820

Haas, Andrew R; Sterman, Daniel H

2013-09-01

438

Liver transplantation for malignancies.  

Science.gov (United States)

Liver transplantation (LT) has become an acceptable and effective treatment for selected patients with hepatocellular carcinoma with excellent outcomes. More recently, LT has been tried in different primary and secondary malignancies of the liver. The outcomes of LT for very selected group of patients with hilar cholangiocarcinoma (CCA) have been promising. Excellent results have been reported in LT for patients with unresectable hepatic epithelioid hemangioendothelioma (HEHE). In contrast to excellent results after LT for HEHE, results of LT for angiosarcoma have been disappointing with no long-term survivors. Hepatoblastoma (HB) is the most common primary liver cancer in pediatric age group. Long-term outcomes after LT in patients with unresectable tumor and good response to chemotherapy have been promising. Indication for LT for hepatic metastasis from neuroendocrine tumors (NETs) is mainly for patients with unresectable tumors and for palliation of medically uncontrollable symptoms. Posttransplant survival in those patients with low tumor activity index is excellent, despite recurrence of the tumor. More recent limited outcomes data on LT for unresectable hepatic metastases from colorectal cancer have claimed some survival benefit compared to the previous reports. However, due to the high rate of tumor recurrence in a very short time after LT, especially in the era of organ shortage, this indication has not been favored by the transplant community. PMID:24604263

Eghtesad, Bijan; Aucejo, Federico

2014-09-01

439

Malignant sigmoidoduodenal fistula  

Science.gov (United States)

INTRODUCTION Duodenocolic fistula is a rare complication of malignant colonic disease especially when involving and originating from the sigmoid colon. We aim to discuss the unusual clinical presentation of this case as well as the investigation and management of duodenocolic fistulas. PRESENTATION OF CASE A 91 year old lady presented as an emergency to a general surgical service at a District General Hospital with diarrhoea, vomiting and weight loss. Computed Tomography (CT) reported a large ovarian cyst elevating the sigmoid colon into immediate proximity of the duodenum. Adenocarcinoma was confirmed on histology obtained by colonoscopy. A classic apple core lesion with fistulating tract from the sigmoid colon to the duodenum was synchronously demonstrated on barium enema. DISCUSSION Sigmoido-duodenal fistulae represent a complex manifestation of gastrointestinal pathologies. CONCLUSION Management options must be considered in the context of patient wishes, their co-morbidities, and predicted post-operative outcome. In most cases this is likely to represent a non-operative approach, however surgical resection may benefit selected cases on occasion. PMID:25460456

Shapey, I.M.; Mahmood, K.; Solkar, M.H.

2014-01-01

440

Environmental malignant mesothelioma in southern Anatolia: a study of fifty cases.  

Science.gov (United States)

Malignant mesothelioma is a highly aggressive tumor of the serous membranes, which in humans results from exposure to asbestos and asbestiform fibers. Although occupational malignant mesothelioma is still the most common form of this lesion, naturally contaminated soil can play an important role in the development of environmental malignant mesothelioma in some parts of the world. Fifty cases of malignant mesothelioma (MM) from southern Turkey with no occupational history of asbestos exposure were reviewed regarding pathologic and clinical features. A case of hyaline fibrous plaque of the pleura was also included in this series. Histologically the cases were classified as epithelial (36 cases); sarcomatous (7 cases); and biphasic (7 cases). One of the sarcomatous cases was desmoplastic. Ultrastructural examination of the tumor tissue in three cases revealed long-surface microvilli in epithelial cells. Interstitial cells of the lung in one case showed electron-dense asbestos fibers in the cytoplasm. Mineralogical analyses of the lung tissue in three cases of MM and the case of pleural plaque showed high amounts of asbestos fibers most consistent with tremolite and actinolite. The clinical and pathologic features of our cases support that the environmental inhalation of asbestos is still a major health problem in some parts of Turkey. PMID:11102295

Zeren, E H; Gümürdülü, D; Roggli, V L; Zorludemir, S; Erki?i, M; Tuncer, I

2000-11-01