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Sample records for malignant fibrous histiocytomas

  1. Intraperitoneal malignant fibrous histiocytoma

    International Nuclear Information System (INIS)

    Two cases of liver metastasis detected in the follow-up of intraperitoneal malignant fibrous histiocytoma (MFH) are reported. Both patients were studied by ultrasonography (US) and computerized tomography (CT), accompanied in the follow-up study by magnetic resonance. (Author)

  2. Postirradiation malignant fibrous histiocytoma

    International Nuclear Information System (INIS)

    A slowly growing, firm, asymptomatic tumor developed in the skin overlying the left scapula of a 72-year-old woman during a six-month period. Twenty-seven years earlier, she had radiation treatment to that site for an intraductal carcinoma of the left breast. The histopathologic diagnosis was malignant fibrous histiocytoma (MFH). The rarity of this late complication of radiation therapy is reflected by a few reports in the medical literature of cutaneous MFH as late radiation sequelae

  3. Radiation-induced intracranial malignant fibrous histiocytoma

    International Nuclear Information System (INIS)

    An autopsy case of radiation-induced intracranial malignant fibrous histiocytoma (fibroxanthosarcoma) is reported. The tumor developed in the region of the sella turcica 11 years after high dose radiotherapy of a chromophobe adenoma of the pituitary. The tumor had infiltrated the base of the brain as well as the base of the skull. Metastases were not found. The tumor was composed of an admixture of bizarre fibroblasts, histiocytes and giant cells, xanthoma cells and siderophages, with a storiform fibrous stroma. This appears to be the first documented instance of a malignant fibrous histiocytoma occurring intracranially after local x irradiation

  4. General Information about Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

    Science.gov (United States)

    ... Health Professional Ewing Sarcoma Treatment Osteosarcoma Treatment Research Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQ®) General Information About Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Key Points ...

  5. Stages of Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

    Science.gov (United States)

    ... Health Professional Ewing Sarcoma Treatment Osteosarcoma Treatment Research Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQ®) General Information About Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Key Points ...

  6. Treatment Option Overview (Osteosarcoma and Malignant Fibrous Histiocytoma of Bone)

    Science.gov (United States)

    ... Health Professional Ewing Sarcoma Treatment Osteosarcoma Treatment Research Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQ®) General Information About Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Key Points ...

  7. Treatment Options for Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

    Science.gov (United States)

    ... Health Professional Ewing Sarcoma Treatment Osteosarcoma Treatment Research Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQ®) General Information About Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Key Points ...

  8. Malignant fibrous histiocytoma with skeletal involvement

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    Takechi,Hideo

    1978-10-01

    Full Text Available Malignant fibrous histiocytoma of soft part is rather common but malignant fibrous histiocytoma of the bone is rarely encountered clinically. Authors present five cases of malignant fibrous histiocytoma with skeletal involvement and discuss their clinical course, x-ray findings and histological features. This tumor has marked tendency for local recurrence and metastasis. Other bone tumors such as giant cell tumor, aneurysmal bone cyst, non ossifying fibroma, osteosarcoma, fibrosarcoma of bone and metastatic cancer can be excluded by several characteristic findings observed in x-rays as well as histopathological features. All information on the patient should be carefully analysed, because it is difficult to decide whether bone involvement is primary or secondary. Four out of five cases definitely originated within the bone.

  9. Postirradiation sarcoma (malignant fibrous histiocytoma) following cervix cancer

    International Nuclear Information System (INIS)

    A case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 11 years following postoperative external beam radiation therapy (7,000 rad) for carcinoma of the cervix. Reports of postirradiation malignant fibrous histiocytoma are rare, and the occurrence of this neoplasm following treatment for cervix cancer has not previously been described. The literature concerning postirradiation bone and soft tissue sarcomas is briefly reviewed, with special attention to malignant fibrous histiocytomas. (author)

  10. Recurrent Atypical Fibroxanthoma Versus Malignant Fibrous Histiocytoma.

    Science.gov (United States)

    Branch, Leslie G; Albertini, John G; Leshin, Barry

    2015-06-01

    Atypical fibroxanthoma (AFX) has been characterized variously as a benign noninvasive neoplasm with rare recurrence. We report 2 cases of recurrent AFX. There is ongoing controversy over the diagnosis of AFX versus malignant fibrous histiocytoma (MFH) in the clinical context of recurrent AFX. Histopathologic diagnosis of fibrohistiocytic neoplasms can be quite challenging and small foci of cancer can be easily overlooked. This is particularly problematic when scarring associated with recurrent tumors is present. The utility of en face sections, as utilized in Mohs micrographical surgery, and the employment of immunohistochemical stains may be helpful in diagnosis. Recurrence of AFX can occur but is difficult to distinguish from MFH. PMID:26080249

  11. Radiation-induced malignant fibrous histiocytoma

    International Nuclear Information System (INIS)

    Among adult malignant tumors of soft tissue, malignant fibrous histiocytoma (MFH) is the most common type. Its prognosis is poor. We have encountered a case of radiation-induced MFH occurring 8 years after radiotherapy (4500 rad to total pelvis, radium needle: 10 mCiX 2 to intra-vagina) for uterine cervical cancer (IIb). Tumor was located in the retroperitoneum of the right fossa iliaca and resected with a part of musculus iliopsoas. Microscopically, two cell pattern contained a greater number of large, bizarre histiocytic cells and plumper fibroblastic cells. Specimen did not show storiform pattern clearly, but was positive for ?1-antichymotrypsin, ?1-antitrypsin and vimentin by immunofluorescence staining. Electron microscopy revealed multinucleated giant cells with a moderate amount of rough endoplasmic reticulum in the cytoplasm. This case had a history of radiation therapy, occurence of second tumor in the radiation field, second tumor occurring over the 2 years latent periods after radiation, and second tumor with different histological findings. This case represents radiation induced malignant fibrous histiocytoma. (author)

  12. Retroperitoneal Malignant Fibrous Histiocytoma Can Mimic a Hydatid Cyst

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    Kenan Cal?skan; Emine Tuba Canpolat; Zafer Koc; Serife Ulusan; Gurcan Erbay

    2011-01-01

    Malignant fibrous histiocytoma is the second most common soft-tissue sarcoma in adults. After the extremities, the retroperitoneal space is the second most common site of this tumor. A 50-year-old man presented with a right retroperitoneal, thick-walled, cystic multilocular mass measuring 10?×?10?cm that was thought to be a type CE 5 hydatid cyst preoperatively. However, the postoperative histopathology did not agree with the radiological findings and instead showed a malignant fibrous histio...

  13. Malignant fibrous histiocytoma following radiation therapy of fibrous dysplasia: case report

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    Amin, R.; Ling, R. [Royal Devon and Exeter Hospital (United Kingdom)

    1995-10-01

    Malignant fibrous histiocytoma commonly occurs spontaneously. In some cases it follows previous therapeutic or incidental irradiation, or miscellaneous pre-existing osseous conditions. Recently, it has been associated with total hip arthroplasty. We report a case of malignant fibrous histocytoma following radiation therapy of fibrous dysplasia and review literature. (author).

  14. Cerebral Metastases from Malignant Fibrous Histiocytoma of Bone

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    Susanne J. Rogers; Whelan, Jeremy S.

    2000-01-01

    Four patients with malignant fibrous histiocytoma of bone (MFH-B) metastasizing to brain are reported. In two cases, signs of cerebral involvement developed between 4 and 28 months after diagnosis. Both patients had known pulmonary or bony metastases. As a consequence of this experience, two further patients were subsequently identified, one with a definite cerebral metastasis and one who had an asymptomatic supratentorial lesion, possibly metastatic. It is suggested that patients ...

  15. Malignant fibrous histiocytoma of the lower lip: A case report

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    Pechalova Petia F

    2012-01-01

    Full Text Available Malignant fibrous histiocytoma (MFH represents the diagnosis that is still commonly used by both patients and physicians although in 2002., the World Health Organization (WHO declassified MFH as a formal diagnostic entity, renaming it as an undifferentiated pleomorphic sarcoma not specifying it further. MFH is extremely rare in the oral cavity. The aim of this article was to describe a newly diagnosed case of primary MFH in a 78-year-old male presented after 4-months history of rapidly increasing swelling of lower lip. Histopathology of the lesion showed highly malignant cell infiltration with epithelioid/spindle cell type morphology. Immunohistochemical study was positive for vimentin (++, S-100 protein (++ and negative for desmin and cytokeratin. The authors discussed the possibilities of immunohistochemical study and necessity of individual treatment plan in patients with MFH, comparing their point of view with other studies.

  16. Single somatic ras gene point mutation in soft tissue malignant fibrous histiocytomas.

    OpenAIRE

    Bohle, R M; Brettreich, S.; Repp, R.; Borkhardt, A.; Kosmehl, H.; Altmannsberger, H. M.

    1996-01-01

    The frequency of ras gene mutations in human soft tissue malignant fibrous histiocytomas within and around the hot spot codons (12, 13, and 61) of all ras genes, (H-ras-1, K-ras-2, and N-ras) was studied by nested polymerase chain reaction and direct DNA sequencing from archival formalin-fixed, paraffin-embedded tissue. Light microscopy and immunohistochemistry served to define malignant fibrous histiocytoma. All of the four differentiation subtypes (storiform-pleomorphic, inflammatory, myxoi...

  17. MALIGNANT FIBROUS HISTIOCYTOMA OF THE PENIS A CASE REPORT AND REVIEW OF THE LITERATURE

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    Tufan Tarcan

    2009-01-01

    Full Text Available Penile malignant fibrous histiocytoma is an extremely rare tumor. To the best of our knowledge, we present here the fifth primary malignant fibrous histiocytoma of the penis. The patient presented with lung metastasis which initially responded well to systemic chemotherapy with Adriamycin and Ifosfamide, but recurred soon after. The local lesion did not respond to chemotherapy and the patient had to undergo a palliative penectomy. The disease progressed rapidly and the patient died one year after the diagnosis.

  18. Histiocitoma fibroso maligno / Histiocytome fibreux malin / Malignant fibrous histiocytoma

    Scientific Electronic Library Online (English)

    Hiralio, Collazo Álvarez; Dewar, Torrecilla Silverio; Jorge Luis, Morales Florat; Stephens Yecc, Collazo Marín.

    2012-06-01

    Full Text Available Introducción: los sarcomas son tumores malignos de partes blandas que representan 0,7 % de los tumores malignos en general, con una tasa de 3 por cada 100 000. El histiocitoma fibroso maligno resulta un tumor de alto grado incluido en el grupo de los sarcomas de partes blandas. Objetivo: exponer las [...] características citohistológicas, el tratamiento y la evolución de este tumor en un caso estudiado y tratado en el Hospital General Provincial Docente "Roberto Rodríguez Fernández" de Ciego de Ávila. Descripción: se presentó el caso de un varón de 60 años con una gran masa de partes blandas en el muslo izquierdo, de crecimiento progresivo. La masa se trató quirúrgicamente con exéresis en bloque, previos estudios analíticos, arteriografía femoral y ecografía. Conclusiones: el diagnóstico anatomopatológico fue de histiocitoma fibroso maligno variedad pleomórfica; fue remitido al servicio de oncología donde lo trataron con radioterapia. A los 6 meses se encontraba libre de la enfermedad. Se realizó una revisión de la literatura y se analizó su presentación clínica, también los hallazgos histológicos, las pruebas diagnósticas de imagen y el procedimiento terapéutico. Abstract in english Introduction: the sarcomas are soft tissue malignant tumors accounting for the 0.7 % of malignant tumors in general with a rate of 3 by 100 000. The malignant fibrous histiocytoma is a high grade tumor included in the group of soft tissue tumors. Objective: to expose the cytohistologic features, tre [...] atment and course of this tumor in study case and treated in "Roberto Rodríguez Fernández" Teaching Provincial Hospital of Ciego de Avila municipality. Description: this is the case of a male patient aged 60 presenting with an increasing large soft tissue mass in the left thigh. The mass was operated on with block exeresis, analytical previous studies, femoral arteriography and echography. Conclusions: the anatomic and pathologic diagnosis was a malignant fibrous histiocytoma pleomorphous type; the patient was referred to Oncology service where was treated with radiotherapy. At 6 months he was free of disease. A review of literature was performed analyzing its clinical presentation also, its histological findings, the imaging diagnostic test and the therapeutical procedure.

  19. Some epidemiological characteristics of malignant fibrous histiocytoma in the Province of Vojvodina

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    Nikolin Borislava L.

    2005-01-01

    Full Text Available BACKGROUND: Malignant fibrous histiocytoma is most common soft tissue sarcoma occurring in late adult life, most in the extremities and in the retroperitoneum, usually developing in deep fascia or skeletal muscle. Because of the aggressive nature of the tumor early and complete surgical removal is indicated. The overall survival rate of patients with malignant fibrous histiocytoma ranges from 36% to 58% at 5 years. Malignant fibrous histiocytoma in Vojvodina is still rare malignancy either in incidence or in mortality in both sexes. The population of Vojvodina is about 2 100 000. METHODS: We used a descriptive epidemiological method to analyze incidence and mortality from malignant fibrous histiocytoma in Vojvodina. This study is based on the Cancer Registry data for the ten-year period from 1993 to 2002. RESULTS: During the observed period 37 cases of malignant fibrous histiocytoma were reported (19 men and 18 women. The average age of patients was 50 years. The body site distribution differed between sexes and malignant fibrous histiocytoma was more common on the trunk (retroperitoneum in men and on the lower limbs in women. The average annual incidence rate for the observed period was 1.82 per 1 000 000 for both sexes. The incidence rate changed irregularly over the observed period with the peak of 9 cases (4.55 per 1 000 000 in 2001. The overall linear trends of incidence and of mortality showed a slight increasing tendency in both sexes, but not significantly. Concerning mortality, the similar patterns were noticed. The mortality rate was 0.83 per 1 000 000. CONCLUSION: According to epidemiological data we obtained it can be concluded that Province of Vojvodina is not a region with an important risk for malignant fibrous histiocytoma; however, the increase of incidence appearing in both men and women should be taken into account very seriously in future.

  20. Malignant fibrous histiocytoma originating from the mesorectum: a case report

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    Torigoe Takayuki

    2011-02-01

    Full Text Available Abstract Background Malignant fibrous histiocytoma (MFH is a common sarcoma affecting soft tissues of the body, especially of the extremities or trunk. Prognosis of the abdominal MFH is usually poor. Case presentation A 52-year-old female presented to our surgical outpatient clinic with a lower abdominal tumor that had been gradually increasing in size. Clinical examination revealed a firm, irregularly surfaced, fixed, painless, child-head-sized tumor located in her lower abdomen. Computed tomography (CT and magnetic resonance imaging (MRI of the abdomen revealed a polycystic tumor at the lower abdomen which was 15 × 13 × 11 cm in diameter and encased the colorectum to the left back side. A barium enema and a colonoscopy showed direct invasion to the rectum. In 2001, the tumor had been excised along with a low anterior resection of the rectum because of direct invasion. The origin of this tumor was the mesorectum. The weight of the excised tumor was 1,500 g, including 800 ml of a brown fluid. A histopathological diagnosis revealed a common type of MFH, in which mitotic figures are frequently seen. Conclusion This patient has survived without recurrence, for approximately 8 years since the completed tumor resection. It is important to obtain a complete resection during the MFH treatment.

  1. Postirradiation sarcoma (malignant fibrous histiocytoma) following uterine cervical cancer

    International Nuclear Information System (INIS)

    A case of postirradiation sarcoma, a malignant fibrous histiocytoma, is described. The tumor occurred in the radiation field (the buttock) 8 years after radiation therapy for keratinizing squamous cell carcinoma of the uterine cervix. The 68-year-old female patient with the inital diagnosis of cervical cancer was treated with pelvic irradiation in 1973. She did well after that with no evidence of disease until 1981 when she developed an enlarging mass in the right buttock within the field of the previous radiation therapy. Microscopically, the tumor at biopsy was composed of pleomorphic histiocyte-like cells, spindle-sphaped cells arranged in a storiform pattern and multinucleated giant cells with bizarre nuclei. Cytodiagnostically, two types of cells, fibroblast-like cells ane histiocyte-like cells, were found. And some cells were considered to be transitional forms, intermediate between fibroblast and histiocytes. Multinucleated pleomorphic giant cells were sometimes seen. Ultrastructurally, the same types of cells were confirmed. These cells contained large numbers of rough endoplasmic reticula with dilated lumens, vacuoles, lysosomal structures, and lipid droplets. (author)

  2. Retroperitoneal Cystic Malignant Fibrous Histiocytoma Mimicking a Psoas Abscess.

    Science.gov (United States)

    Gupta, Madan Mohan; Bahri, Nandini; Watal, Pankaj; Rathod, Ketan; Thaker, Siddarth; Bhandari, Parthiv; Dhamecha, Ketul; Ajudia, Jasmin

    2015-07-01

    Primary neoplasms in the psoas muscle including schwannoma and soft tissue sarcoma with secondary cystic degeneration are rare entities. They are difficult to distinguish from psoas abscess purely based on radiological findings. Malignant fibrous histiocytoma (MFH) in the retroperitoneum is an uncommon entity in contrast to liposarcoma and leiomyosarcoma. Psoas abscess is a common infection in the retroperitoneum, especially in regions where tuberculosis is endemic. In the current case, the patient presented with gradually progressive lower abdominal pain and raised erythrocyte sedimentation rate (ESR), lymphocyte count and sputum positive for acid fast bacilli. There was a presence of previous history of skeletal tuberculosis. Imaging revealed well-defined multilocular cystic lesion involving the left psoas muscle which along with the clinical scenario suggested psoas abscess. However, post-operative biopsy showed the lesion to be a MFH with extensive cystic degeneration. To the best of our knowledge, cystic MFH mimicking an abscess has been previously reported only once in an oncology literature. PMID:26557275

  3. Thallium 201 and Gallium 67 uptake in malignant fibrous histiocytoma of the heart

    International Nuclear Information System (INIS)

    A patient with malignant fibrous histiocytoma of the heart is described who was initially presented with a left atrial tumor. Subsequent 201Tl and 67Ga scintigraphy showed massive uptake of the tracers by the tumor and the pattern of uptake was thought to reflect underlying necrosis and hemorrhage within the tumor

  4. Primary malignant fibrous histiocytoma of the sigmoid colon: a case report.

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    Rubbini, M; Marzola, A; Spanedda, R; Scalco, G B; Zamboni, P; Guerrera, C; Donini, I

    1983-01-01

    This paper presents a case of malignant fibrous histiocytoma localized in the sigmoid colon with multiple metastases in the right lobe of the liver and describes the pathological and microscopic aspects, clinical course and characteristics. The primary localization in the sigmoid colon is extremely rare, this being only the second case reported. PMID:6323346

  5. MRI of malignant fibrous histiocytoma of soft tissue: analysis of 13 cases with pathologic correlation

    International Nuclear Information System (INIS)

    We reviewed the magnetic resonance (MR) appearances of 13 malignant fibrous histiocytomas (MFH) of soft tissue and correlated each with the respective lesion's histopathology. The MR images were evaluated for signal intensity on T1- and T2-weighted spin echo sequences, homogeneity of the lesion, presence of internal low signal septations, and margin definition. Histologic subtypes of MFH included storiform-pleomorphic, giant cell, myxoid, and inflammatory. We could not establish a correlation between MR appearance and histopathology. Instead, our series exhibited general features suggestive of malignant soft tissue neoplasms, namely poor margin definition, internal low signal septation, and heterogeneous high signal intensity on T2-weighted images. (orig.)

  6. Radiological findings of primary abdominal malignant fibrous histiocytoma : emphasis on CT findings

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    Lee, Kang Hoon; Lee, Hae Giu; Lee, Jae Mun; Baik, Jun Hyun; Yu, Won Jong; Kim, Jong Kyu; Yim, Jung Ik; Shinn, Kyung Sub [Catholic Univ. Medical College, Seoul (Korea, Republic of); Lee, Hong Jae; Ha, Hyun Kwon [Asan Medical Center, Ulsan Univ. College of Medicine, Seoul (Korea, Republic of)

    1996-10-01

    To evaluate the radiological findings of abdominal malignant fibrous histiocytomas We retrospectively reviewed the radiological findings of 13 masses in seven patients including two patients with multiple masses. The masses were located at the mesentery and omentum in three patients and at the retroperitoneum in four. Gastrointestinal examination using barium was performed in four patients, ultrasonography in five and computed tomography in all. The average diameter of masses was 7.8cm(range:1-20cm);plain abdominal films revealed soft tissue masses in all patients. Three of four barium studies demonstrated only displacement of bowel loops and the other showed findings of submucosal tumor. Eight of 11 masses were detected on ultrasonography and all were round or lobulated and had well defined margins. Four of these masses were greater than 8cm in diameter and showed homogeneous echogenicity with central hypo or anechoic area;the remaining were less than 8cm and showed relatively homogeneous echogenicity. On computed tomography, all 13 masses were seen as highly enhanced and well circumscribed. Seven were greater than 5cm in diameter and had internal low-density areas. Peritumoral vessel-like structures were seen in eight masses and on plain abdominal radiograph and computed tomogram, calcification was seen in one patient. In no patient was combined retroperitoneal or intraperitoneal lymphadenopathy noted. Abdominal malignant fibrous histiocytomas are well-circumscribed, round or lobulated bulky masses with frequent necrosis and occasional calcification. Characteristically, there is no combined lymphadenopathy and multiple masses are a rare manifestation. These findings may be helpful in the diagnosis of malignant fibrous histiocytoma.

  7. Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature

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    Yao Dianbo

    2012-01-01

    Full Text Available Abstract Background A malignant fibrous histiocytoma is a soft tissue tumor that most commonly occurs in the extremities, but rarely involves the liver. The clinical characteristics and therapeutic experiences of primary hepatic malignant fibrous histiocytoma are still limited. Methods Two cases of primary hepatic malignant fibrous histiocytoma were analyzed retrospectively, and all the literature concerning primary hepatic malignant fibrous histiocytoma was analyzed. Results In China, a total of 76 cases had been reported, among which 50 were men, with a male to female ratio of 1.9:1. Mean age of the patients was 51.0 years old, and more than 85 percent were older than 40 years. 82.9 percent (63/76 of hepatic MFH were solitary lesions, with tumor size ranging from 2.5 to 23.5 cm (average 10.3 cm. Major clinical presentation (78.4% was abdominal pain or discomfort, accompanied with some other non-specific symptoms such as malaise, anorexia, weight loss, jaundice and fever, and small cases (14.9% were asymptomatic. Computed tomography and ultrasound usually revealed the location of lesions. The rate of pre-operative misdiagnosis was extremely high, and 14.9 percent of patients were even misdiagnosed as a benign liver cyst, liver abscess or hematoma. Integrated resection was performed among the most cases (49/68, among which only a few ones (12 cases were introduced to have no recurrence or metastasis or be still alive with no detail information provided, while among the cases with palliative operation or only a biopsy, the cases that were followed-up all died. Conclusions Hepatic malignant fibrous histiocytoma is a rare malignant mesenchymal tumor. The variable features of clinical presentations and images make the diagnosis difficult. Though the prognosis of primary hepatic malignant fibrous histiocytoma was rather poor, integrated resection might provide a few cases a good opportunity for surviving, suggesting that surgery might be an effective treatment.

  8. Post-radiation malignant fibrous histiocytoma following treatment of breast cancer: A case report

    International Nuclear Information System (INIS)

    Post-radiation malignant fibrous histiocytoma (MFH) of the breast is extremely rare. We report a case of post-radiation MFH that presented a rapidly growing mass in a 52-year-old woman who underwent breast-conserving therapy and adjuvant whole breast irradiation 6 years ago. To the best of our knowledge, only one case of primary MFH of the female breast have been reported with sonographic findings. We analyzed the sonographic and MRI findings with correlative histopathologic features, and then confirmed with surgical excision.

  9. An 11 kg Malignant Fibrous Histiocytoma in a 54-Year-Old Patient: A Case Report

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    Ghadir M.R

    2011-08-01

    Full Text Available Background and Objectives: Malignant fibrous histiocytoma (MFH is a soft tissue sarcoma of undifferentiated mesenchymal cell origin which is considered the most common soft tissue sarcoma in adults. It commonly occurs in the 5th and 6th decades with a 2-to-1 male to female ratio. It most frequently occurs in the extremities and retroperitoneum. Most of it is derived from soft tissues and some of it from bone tissue. In this study, we introduce a patient who had MFH in retroperitoneal area and at the time of diagnosis the tumor size and weight had reached a significant level.Case Report: The patient is a 54-year-old male that referred to the hospital with complaints of pain and fullness in the abdomen. His pain had started from two years ago and had been accompanied with early satiation, bloating, weight gain and hypertension. On physical examination, asymmetric enhancement was visible. After diagnosis of mass and investigation of its development in abdomen and pelvic with CTscan, the patient was underwent operation and a mass with about 11kg of weigh was resected. During pathologic investigation, high grade spindle cell sarcoma and malignant fibrous histiocytoma were reported. After resection of tumor, the abdominal pain of patient disappeared and additionally his blood pressure came back to normal levels.

  10. An 11 kg Malignant Fibrous Histiocytoma in a 54-Year-Old Patient: A Case Report

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    M.R Ghadir

    2012-05-01

    Full Text Available

    Background and Objectives: Malignant fibrous histiocytoma (MFH is a soft tissue sarcoma of undifferentiated mesenchymal cell origin which is considered the most common soft tissue sarcoma in adults. It commonly occurs in the 5th and 6th decades with a 2-to-1 male to female ratio. It most frequently occurs in the extremities and retroperitoneum. Most of it is derived from soft tissues and some of it from bone tissue. In this study, we introduce a patient who had MFH in retroperitoneal area and at the time of diagnosis the tumor size and weight had reached a significant level.

     

    Case Report: The patient is a 54-year-old male that referred to the hospital with complaints of pain and fullness in the abdomen. His pain had started from two years ago and had been accompanied with early satiation, bloating, weight gain and hypertension. On physical examination, asymmetric enhancement was visible. After diagnosis of mass and investigation of its development in abdomen and pelvic with CTscan, the patient was underwent operation and a mass with about 11kg of weigh was resected. During pathologic investigation, high grade spindle cell sarcoma and malignant fibrous histiocytoma were reported. After resection of tumor, the abdominal pain of patient disappeared and additionally his blood pressure came back to normal levels.

     

  11. Report of a Rare Case of Malignant Fibrous Histiocytoma of Mandible

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    Fatemeh Ahmadi-Motamayel

    Full Text Available Introduction: Malignent Fibrous Histiocytoma (MFH is the most frequent soft tissue sarcoma of adulthood. The most common sites affected by MFH are limbs, orbit, retroperitoneum, pelvis and knee. Oral cavity and mandible involvements are very rare. Case Report: A 35-year-old male was visited in the oral medicine department of Hamadan dental school with the chief complaint of pain and teeth mobility. The patient also had a history of paresthesia in lower lip for two monthes. In intraoral examination, there was a crater like, deep and disseminated ulcer in lower buccal and ligual gingiva of right mandibular teeth and exophitic lesion with smooth surface, and color similar to normal mucosa with 2×2×3 cm in diameter in buccal and lingual part of right lateral and central teeth extended to left second premolar was observed. Gingival resorption was observed in all adjascent teeth. There was radiolucency with irregular border in all part of lesion. MFH was confirmed by histopathological report.Conclusion: The most common complaint of patients with malignant fibrous histiocytoma is the growing mass that could be ulcerative or painful. Early diagnosis and referral is very important in prognosis and survival of the patients.

  12. Radiology and pathology of malignant fibrous histiocytomas of the soft tissues; a report of ten cases

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    Fischer, H.J.; Lois, J.F.; Gomes, A.S.; Mirra, J.M.; Deutsch, L.S.

    1985-03-01

    Malignant fibrous histiocytomas (MFH) are believed to originate from histiocytes and are composed of malignant cells with spindle or round shapes. We evaluated ten MFH of the soft tissues by plain roentgenograms, computed tomography (CT), and angiography and subdivided them into four grades of anaplasia and five predominant histologic variants. The variants of MFH demonstrated different vascular patterns. The extension of the lesions could be determinded by CT and angiography. CT is the method of choice in the assessment of size and extent of MFH of the soft tissues. When intra-arterial chemotherapy is indicated the angiograms obtained at each catheter placement may substitute CT in follow-up studies obviating additional diagnostic procedures.

  13. Radiology and pathology of malignant fibrous histiocytomas of the soft tissues a report of ten cases

    International Nuclear Information System (INIS)

    Malignant fibrous histiocytomas (MFH) are believed to originate from histiocytes and are composed of malignant cells with spindle or round shapes. We evaluated ten MFH of the soft tissues by plain roentgenograms, computed tomography (CT), and angiography and subdivided them into four grades of anaplasia and five predominant histologic variants. The variants of MFH demonstrated different vascular patterns. The extension of the lesions could be determinded by CT and angiography. CT is the method of choice in the assessment of size and extent of MFH of the soft tissues. When intra-arterial chemotherapy is indicated the angiograms obtained at each catheter placement may substitute CT in follow-up studies obviating additional diagnostic procedures. (orig.)

  14. Malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma of the penis. A case report

    International Nuclear Information System (INIS)

    We report the case of a malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (MFH/UPS) of the penis in a 78-years-old-man who had undergone previous radical prostatectomy, external beam radiation therapy for prostatic adenocarcinoma. The mass was a 9-cm firm lesion at the base of the penis predominantly composed of malignant spindle cells arranged in sweeping fascicles and storiform pattern. The tumor cells stained for vimentin, ?-smooth muscle actin, S-100, and were negative for keratin, desmin, Melan A, prostate specific antigen (PSA). Despite total penectomy, he developed a local reccurence 4 months after surgery, and died from dissemination 6 months after surgery. This is the 8th case of penile MFH/UPS. (author)

  15. Adrenal metastases in a post-radiation malignant fibrous histiocytoma after low-dose radiation for a benign condition

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    Ganesan, Prasanth; Kaushal, Seema; Thulkar, Sanjay; Bakhshi, Sameer

    2013-01-01

    A 29-year-old male presented with an aggressive malignant fibrous histiocytoma of his leg 14 years after he had received low-dose radiation to the area for a benign indication. The other unusual feature of this case was the large unilateral adrenal metastasis. We describe this very rare presentation of sarcoma and briefly review the relevant literature.

  16. Adrenal metastases in a post-radiation malignant fibrous histiocytoma after low-dose radiation for a benign condition

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    Prasanth Ganesan

    2013-01-01

    Full Text Available A 29-year-old male presented with an aggressive malignant fibrous histiocytoma of his leg 14 years after he had received low-dose radiation to the area for a benign indication. The other unusual feature of this case was the large unilateral adrenal metastasis. We describe this very rare presentation of sarcoma and briefly review the relevant literature.

  17. A case of radiation-induced pelvic malignant fibrous histiocytoma 8 years after radiotherapy for uterus cervical cancer

    International Nuclear Information System (INIS)

    A case of postradiation malignant fibrous histiocytoma of the pelvis was reported. The patient is a 79-year-old woman. She was treated by radiation for cervical cancer of the uterus 8 years ago. The problem of second cancer will be more important in cancer treatment. (author)

  18. MRI of angiomatoid fibrous histiocytoma

    Energy Technology Data Exchange (ETDEWEB)

    Li, Chao-Shiang; Chen, Wei-Tsung; Chen, Ran-Chou; Tu, Hsing-Yang [Taipei Municipal Jen-Ai Hospital, Department of Radiology, Taipei (Taiwan); Chan, Wing P. [Taipei Medical University, Department of Radiology, School of Medicine, Taipei (Taiwan); Taipei Municipal Wan-Fang Hospital, Department of Radiology, Taipei (Taiwan); Chang, Chih-Peng [Taipei Municipal Jen-Ai Hospital, Department of Orthopedic Surgery, Taipei (Taiwan); Shih, Li-Sun [Taipei Municipal Jen-Ai Hospital, Department of Pathology, Taipei (Taiwan)

    2004-10-01

    Angiomatoid fibrous histiocytoma is a rare soft tissue tumor of low-grade malignancy. We present the case of a 32-year-old man who complained of soreness and numbness over his left arm and hand over the previous 2 months and of having a palpable mass over his left upper back for 4 years. Magnetic resonance imaging (MRI) showed an intramuscular soft tissue mass in the left scapular region. The tumor mass was seen to have multiple cystic components with fluid-fluid levels. Histological examination showed multiple cystic spaces filled with blood lakes and hemosiderin deposits in the solid part of the tumor. After the initial surgery, the patient had local recurrences over 2.5 years. The immunohistochemical study at the second surgery showed that the recurrent tumor was strongly positive for the histiocytic marker CD68, and the myoid trait desmin. Histological diagnosis was compatible with angiomatoid fibrous histiocytoma. (orig.)

  19. MRI of angiomatoid fibrous histiocytoma

    International Nuclear Information System (INIS)

    Angiomatoid fibrous histiocytoma is a rare soft tissue tumor of low-grade malignancy. We present the case of a 32-year-old man who complained of soreness and numbness over his left arm and hand over the previous 2 months and of having a palpable mass over his left upper back for 4 years. Magnetic resonance imaging (MRI) showed an intramuscular soft tissue mass in the left scapular region. The tumor mass was seen to have multiple cystic components with fluid-fluid levels. Histological examination showed multiple cystic spaces filled with blood lakes and hemosiderin deposits in the solid part of the tumor. After the initial surgery, the patient had local recurrences over 2.5 years. The immunohistochemical study at the second surgery showed that the recurrent tumor was strongly positive for the histiocytic marker CD68, and the myoid trait desmin. Histological diagnosis was compatible with angiomatoid fibrous histiocytoma. (orig.)

  20. Malignant fibrous histiocytoma of the urinary bladder as a post-radiation secondary cancer: a case report

    Directory of Open Access Journals (Sweden)

    Nimmanon Thirayost

    2011-11-01

    Full Text Available Abstract Introduction Malignant fibrous histiocytomas have been periodically reported as the primary tumor in various organs including the urinary bladder, and is the second most frequent sarcoma of the urinary tract in adults. This report discusses a case of the well established diagnosis of a malignant fibrous histiocytoma of the bladder occurring as a post-radiation cancer after the treatment of a cervical carcinoma. Our findings support those of many previous studies and make the view of the nature of the disease clearer. Case presentation We report the case of a 54-year-old Thai woman who had been treated with radiation therapy for cervical cancer, who presented to our facility with urinary incontinence. Initially, our patient was diagnosed as having a high-grade urothelial carcinoma. Subsequent radical surgery rendered the final pathological diagnosis, confirmed histologically and immunohistochemically as malignant fibrous histiocytoma, with clinical and pathological staging of T4b N0 M0. Adjuvant chemotherapy was provided for our patient. Conclusions This type of malignancy is very aggressive and easily misdiagnosed due to its rarity. Therefore, in a patient with a prior history of irradiation in the pelvic area, this should be considered as a differential diagnosis to ensure early correct diagnosis and treatment.

  1. Primary Malignant Fibrous Histiocytoma of the Right Ventricle and Main Pulmonary Trunk with a Review of the Literature

    OpenAIRE

    Glock, Yves; Binon, J.P.; Rocchichioli, J.P.; Duboucher, Christophe; Kreidi, Rharid; Calazel, Jacques; Puel, Pierre; Bernadet, Pierre

    1989-01-01

    We report the case of a 76-year-old man with a malignant fibrous histiocytoma of the right ventricle and main pulmonary trunk, diagnosed through echocardiography and catheterization. Extensive resection of the right ventricular outflow tract, pulmonary valve apparatus, and main pulmonary trunk was performed, and the defect was repaired with a valveless ventriculo-pulmonary Dacron graft. The patient recovered uneventfully, and was doing well 18 months after surgery.

  2. Histiocitoma fibroso maligno retroperitoneal: A propósito de un caso / Retroperitoneal malignant fibrous histiocytoma: case report

    Scientific Electronic Library Online (English)

    Pablo, Eguíluz Lumbreras; Alberto, Palacios Hernández; Oscar, Heredero Zorzo; Javier, García García; Florencio, Cañada de Arriba; Federico, Pérez Herrero; Ramón, Gómez Zancajo.

    2010-08-01

    Full Text Available Objetivo: Presentar un caso de una tumoración retroperitoneal de gran tamaño con diagnóstico patológico de Histiocitoma fibroso maligno y revisar aspectos diagnósticos y terapéuticos de la literatura actual. Método: Presentamos el caso de un hombre de 75 años de edad que durante un ingreso en el ser [...] vicio de digestivo por clínica de astenia de meses de evolución y problemas gastrointestinales se realiza CT abdomino-pélvico, identificando gran masa de 20 x 22 x 12 cm que parece depender del riñón izquierdo junto a aneurisma de aorta abdominal de 8 cm de diámetro. Resultados: Se somete al paciente a intervención quirúrgica donde se realiza Nefrectomía radical izquierda más resección radical de masa retroperitoneal, que histológicamente corresponde a un Histiocitoma fibroso maligno, tipo estoriforme-pleomórfico con focos de degeneración hialina (Estadio pT2b). Conclusiones: Los sarcomas son neoplasias infrecuentes. Pueden adoptar una gran variedad de patrones morfológicos y distintos grados de diferenciación. El tratamiento quirúrgico continúa siendo la única terapia con posibilidades curativas. El tratamiento adyuvante radioterápico y/o quimioterápico es cuestionado. Abstract in english Objective: We present the case of a big retroperitoneal tumor that received the pathologic diagnosis of malignant fibrous histiocytoma. We also review the diagnostic and therapeutic features of this disease in the current literature. Methods: We present the case of a 75-year-old male who was admitte [...] d to the Gastrointestinal Disease Department with asthenia of several months of evolution and gastrointestinal problems. Abdominopelvic CT scan revealed a big mass of 20 x 22 x 12 cm, which seems to depend from the left kidney, together with an 8 cm diameter abdominal aortic aneurysm. Results: The patient underwent surgery and left radical nephrectomy together with radical resection of the retroperitoneal mass were performed. Pathology reportes malignant fibrous histiocytoma of the storiform-pleomorphic type, with hyaline degeneration foci (stadium pT2B). Conclusions: Sarcomas are rare neoplasias. They can adopt several different morphologic patterns, as well as many differentiation degrees. The surgical treatment is still the only therapy with healing possibilities. Adjuvant treatments through radiotherapy and/or chemotherapy are brought into question.

  3. Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report

    International Nuclear Information System (INIS)

    A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

  4. Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hye Young; Seo, Jung Wook; Lee, Byung Hoon; Lee, Ji Young; Kim, Su Young; Cha, Soon Joo; Kim, Yong Hoon; Hwang, Yoon Joon; Kim, You Sung [Dept. of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang (Korea, Republic of)

    2013-03-15

    A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

  5. Primary malignant fibrous histiocytoma of the abdominal cavity: CT findings and pathological correlation

    Directory of Open Access Journals (Sweden)

    Bivek Karki

    2012-01-01

    Full Text Available AIM: To study computed tomography (CT features of abdominal malignant fibrous histiocytoma (MFH in various rare locations. METHODS: We retroprospectively identified cases of MFH involving the abdominal cavity. Particular attention was paid to details regarding imaging features and histological types. RESULTS: The study population consisted of seven men and one woman, with a mean age of 52.5 years. Seven patients had some physical symptoms, while one was incidentally detected. The sites of origin were liver (n = 3, greater omentum (n = 1, superior mesentery (n = 1, ileum (n = 1, right psoas muscle (n = 1 and right kidney (n = 1. With the exception of the ileum lesion, all were of huge size. The contour of the lesions was more or less clear. Foci of necrosis were present in six lesions (n = 6. On plain CT scan, all lesions were hypo to iso dense. The lesion in the greater omentum was cystic. One lesion (n = 1 showed significant enhancement and the cystic lesion showed mild peripheral enhancement. An abundance of blood vessels surrounding the mass was seen in two lesions (n = 2 and both were of the inflammatory variety. Pathological examination revealed storiform-pleomorphic variety (n = 4, inflammatory variety (n = 3 and myxoid variety (n = 1. Two of the patients with inflammatory MFH had a clinical presentation of fever and one was afebrile, however, blood investigations in all three showed leukocytosis. CONCLUSION: Primary MFHs of the abdominal viscera and gastrointestinal tract are generally huge soft tissue masses containing areas of low attenuation and mild to moderate contrast enhancement.

  6. Postirradiation malignant fibrous histiocytoma of the lung. Demonstration of alpha 1-antitrypsin-like material in neoplastic cells

    International Nuclear Information System (INIS)

    A metastasizing fibrous histiocytoma arising in the lung of a patient who received radiation therapy and long-term chemotherapy for malignant lymphoma is presented. Ultrastructural studies revealed fibroblast-like and histiocyte-like cells, cells of intermediate type showing ultrastructural features of both fibroblast-like and histiocyte-like cells, primitive mesenchymal cells, multinucleate tumor cells, and xanthomatous cells. The neoplastic cells showed dilated rough endoplasmic reticula with intracisternal accumulation of electron-dense material forming lattice-like structures. Direct immunofluorescence staining of the neoplastic cells using antihuman alpha 1-antitrypsin showed specific activity, with fluorescent deposits exhibiting interlacing globular formations. These findings and their implications are discussed

  7. An adult patient who developed malignant fibrous histiocytoma 9 years after radiation therapy for childhood acute lymphoblastic leukemia

    International Nuclear Information System (INIS)

    A 24-year-old Japanese man with a history of acute lymphoblastic leukemia, which occurred during childhood, developed malignant fibrous histiocytoma of his left knee. His past history revealed that he had undergone leukemic blast cell invasion of the left knee and subsequent radiation therapy 9 years ago. The total radiation doses for the upper part of the left tibia and the lower part of the left femur were 60 Gy and 40 Gy, respectively. Neither distant metastasis nor a relapse of leukemia occurred. A curative resection of the left femur with a noninvasive margin was performed. Adjuvant chemotherapy including high-dose methotrexate was given successfully before and after surgery; this was followed by relapse-free survival for 3 years. The nature of postirradiation malignant fibrous histiocytoma is highly aggressive. When a patient complains of persistent symptoms in a previously irradiated field, the possibility of this tumor must be taken into account. The importance of early diagnosis cannot be over-emphasized. (author)

  8. An adult patient who developed malignant fibrous histiocytoma 9 years after radiation therapy for childhood acute lymphoblastic leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Yasuhiro [National Hiroshima Hospital, Higashi-Hiroshima (Japan); Ohno, Norioki; Horikawa, Yoko; Nishimura, Shin-ichiro; Ueda, Kazuhiro; Shimose, Shoji [Hiroshima Univ. (Japan). School of Medicine

    2002-12-01

    A 24-year-old Japanese man with a history of acute lymphoblastic leukemia, which occurred during childhood, developed malignant fibrous histiocytoma of his left knee. His past history revealed that he had undergone leukemic blast cell invasion of the left knee and subsequent radiation therapy 9 years ago. The total radiation doses for the upper part of the left tibia and the lower part of the left femur were 60 Gy and 40 Gy, respectively. Neither distant metastasis nor a relapse of leukemia occurred. A curative resection of the left femur with a noninvasive margin was performed. Adjuvant chemotherapy including high-dose methotrexate was given successfully before and after surgery; this was followed by relapse-free survival for 3 years. The nature of postirradiation malignant fibrous histiocytoma is highly aggressive. When a patient complains of persistent symptoms in a previously irradiated field, the possibility of this tumor must be taken into account. The importance of early diagnosis cannot be over-emphasized. (author)

  9. Malignant fibrous histiocytoma of the deep peri-articular tissue of the stifle in a dog : case report

    Directory of Open Access Journals (Sweden)

    M.J. Booth

    1998-07-01

    Full Text Available A Belgian shepherd dog aged 4 years and 9 months was presented with acute onset of non-weight bearing lameness and stifle effusion of the left hind limb, caused by the deep form of a malignant fibrous histiocytoma originating in the deep musculature and fascia surrounding the stifle joint. The tumour progressed rapidly in the tissues along the femoral diaphysis with marked periosteal new bone formation. Cytology of a stifle joint aspirate revealed numerous large polygonal neoplastic cells with considerable anisocytosis and anisokaryosis. These cells were present in clusters, with cytoplasmic projections between the cells, but occasionally also occurred singly. Several cells contained multiple cytoplasmic vacuoles and occasional giant cells were also encountered. Adequate tumour-free margins were not possible with radical limb amputation and the dog was euthanased. Macroscopically the tumour appeared as an extensive pale tan, firm mass with scattered small haemorrhages and foci of yellow discolouration. Histologically the tumour consisted of dense neoplastic expanses or multiple nodules, composed of spindle-shaped fibroblastic cells, polygonal histiocytic cells or cell clusters and scattered giant cells with 2-3 nuclei. The polygonal neoplastic cells were frequently present around and invading lymphatics and blood vessels, causing neoplastic emboli. This is the 1st report of the clinical behaviour, radiography and cytology of the deep form of malignant fibrous histiocytoma in the dog.

  10. A new complication of retained surgical gauze: development of malignant fibrous histiocytoma – report of a case with a literature review

    Science.gov (United States)

    2012-01-01

    Background Primary visceral malignant fibrous histiocytoma (MFH) is a rare disease, and few cases have been reported in the English literature. However, retained foreign bodies in the abdomen after surgical procedures are important causes of intra-abdominal infections. For legal and ethical reasons, there are few publications in the literature. In this article, we describe for the first time a case of malign abdominal fibrous histiocytoma associated with a surgical sponge forgotten in the abdominal cavity a long time ago. Case presentation A 64-year-old male presented to our surgical department with cachexia, abdominal pain, distention and pyrexia of unknown origin. He had a medical history of abdominal surgery for peptic ulcer perforation 32?years ago. Clinical examination revealed fever with a distended and painful abdominal wall. Radiological imaging of the abdomen showed multiple heterogeneous masses in one large cystic cavityalmost completely filling the abdomen. The patient underwent a laparotomy, and interestingly, opening the cyst revealed retained surgical gauze (RSG). The origin of the tumor was the visceral peritoneum, and it was excised totally. Conclusions Primary intra-abdominal MFH can present as a complication of long-lasting RSG. Therefore, clinicians must remember this while establishing the differential diagnosis for patients with a history of previous abdominal surgery and presenting with symptoms associated with both the tumor and systemic inflammatory response. PMID:22776249

  11. A new complication of retained surgical gauze: development of malignant fibrous histiocytoma – report of a case with a literature review

    Directory of Open Access Journals (Sweden)

    Kaplan Mehmet

    2012-07-01

    Full Text Available Abstract Background Primary visceral malignant fibrous histiocytoma (MFH is a rare disease, and few cases have been reported in the English literature. However, retained foreign bodies in the abdomen after surgical procedures are important causes of intra-abdominal infections. For legal and ethical reasons, there are few publications in the literature. In this article, we describe for the first time a case of malign abdominal fibrous histiocytoma associated with a surgical sponge forgotten in the abdominal cavity a long time ago. Case presentation A 64-year-old male presented to our surgical department with cachexia, abdominal pain, distention and pyrexia of unknown origin. He had a medical history of abdominal surgery for peptic ulcer perforation 32?years ago. Clinical examination revealed fever with a distended and painful abdominal wall. Radiological imaging of the abdomen showed multiple heterogeneous masses in one large cystic cavityalmost completely filling the abdomen. The patient underwent a laparotomy, and interestingly, opening the cyst revealed retained surgical gauze (RSG. The origin of the tumor was the visceral peritoneum, and it was excised totally. Conclusions Primary intra-abdominal MFH can present as a complication of long-lasting RSG. Therefore, clinicians must remember this while establishing the differential diagnosis for patients with a history of previous abdominal surgery and presenting with symptoms associated with both the tumor and systemic inflammatory response.

  12. Malignant fibrous histiocytoma of the distal femur after an arthroscopic anterior cruciate ligament reconstruction: A case report and a review of the literature

    International Nuclear Information System (INIS)

    Malignant degeneration in association with orthopaedic implants is a known but rare complication. To our knowledge, no case of osseous malignant fibrous histiocytoma after anterior cruciate ligament reconstruction is reported in the literature. We report a 29-year-old male Turkish patient who presented with severe pain in the operated knee joint 40 months after arthroscopic anterior cruciate ligament reconstruction. X-ray and MR imaging showed a large destructive tumor in the medial femoral condyle. Biopsy determined a malignant fibrous histiocytoma. After neoadjuvant chemotherapy, wide tumor resection and distal femur reconstruction with a silver-coated non-cemented tumor knee joint prosthesis was performed. Adjuvant chemotherapy was continued according to the EURAMOS 1 protocol. Though secondary malignant degeneration after orthopaedic implants or prostheses is not very likely, the attending physician should take this into consideration, especially if symptoms worsen severely over a short period of time

  13. Diaphyseal medullary stenosis (sclerosis) with bone malignancy (malignant fibrous histiocytoma): hardcastle syndrome

    International Nuclear Information System (INIS)

    Hardcastle syndrome is a rare, autosomally dominant inherited skeletal dysplasia, characterized by diaphyseal sclerosis, medullary stenosis, pathological fractures, bony infarction, and malignant transformation. A 19-year-old proband is presented and discussed, adding a fourth family to the world literature. Radiographic screening of family members is suggested from puberty onward. Thallium scanning is proposed as a more tumor-sensitive screening agent in affected individuals. (orig.). With 2 figs

  14. Incremental value of live/real time three-dimensional transesophageal echocardiography over the two-dimensional technique in the assessment of primary cardiac malignant fibrous histiocytoma.

    Science.gov (United States)

    Gok, Gulay; Elsayed, Mahmoud; Thind, Munveer; Uygur, Begum; Abtahi, Firoozeh; Chahwala, Jugal R; Y?ld?r?mtürk, Özlem; Kayac?o?lu, ?lyas; Pehlivano?lu, Seçkin; Nanda, Navin C

    2015-07-01

    We describe a case of primary cardiac malignant fibrous histiocytoma where live/real time three-dimensional transesophageal echocardiography added incremental value to the two-dimensional modalities. Specifically, the three-dimensional technique allowed us to delineate the true extent and infiltration of the tumor, to identify characteristics of the tumor mass suggestive of its malignant nature, and to quantitatively assess the total tumor burden. PMID:26114896

  15. Oral benign fibrous histiocytoma: two case reports

    OpenAIRE

    Menditti, Dardo; Laino, Luigi; Mezzogiorno, Antonio; Sava, Sara; Bianchi, Alexander; Caruso, Giovanni; Di Maio, Luigi; Baldi, Alfonso

    2009-01-01

    Fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body. The involvement of the oral cavity is rare. We report two cases of benign fibrous histiocytoma that localized in the oral cavity. The clinical and histological features of the lesion are reported. Finally, a literature revision of this pathology at the level of the oral cavity is reported.

  16. Eight-year follow-up of malignant fibrous histiocytoma (undifferentiated high-grade pleomorphic sarcoma of the maxilla: case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Hossein Shahoon

    2009-03-01

    Full Text Available Malignant fibrous histiocytoma (MFH is the most common soft tissue sarcoma of late adult life and may also arise as a primary tumor in bone. It is a rare condition that constitutes less than 1% of the malignant tumors of bone and commonly occurs in the mathaphysis of long bones of extremities such as the femur and tibia. The occurrence in the head and neck region is very rare. MFH of the jaws is a highly malignant tumor that recurs, metastasizes, and usually causes death despite aggressive surgical therapy. We present a case of MFH of maxilla with 8 years follow-up. The clinical, pathologic and radiographic features as well as the treatment of this case are discussed.

  17. Mast Cells Inhibit CD8+ T Cell-Mediated Rejection of a Malignant Fibrous Histiocytoma-Like Tumor: Involvement of Fas-Fas Ligand Axis

    Directory of Open Access Journals (Sweden)

    Shigeto Tohma

    2009-01-01

    Full Text Available Problem statement: Mast cells develop from bone marrow-derived progenitor cells and are distributed in the skin or mucosa where they play proinflammatory roles in the first line of defense. Since some tumors in humans and experimental animals exhibited infiltration of increased mast cells, we investigated the contribution of mast cells to the override of tumor rejection. Approach: MRL/N-1 cells are malignant fibrous histiocytoma-like cells established from the spleen of a Fas ligand (FasL-deficient MRL/Mp-FasLgld/gld (MRL/gld mouse and are implantable in Fas-deficient MRL/Mp-Faslpr/lpr (MRL/lpr mice. MRL/N-1 cells were implanted in MRL/gld, MRL/lpr and MRL/+mice after antibody treatments or with mast cells or macrophages and the tumor growth was observed. Results: MRL/N-1 cells were rejected by Fas-intact syngeneic MRL/+ mice in CD8+ T cell-mediated manner. This rejection was inhibited by the co-implanted mast cells. MRL/N-1 cells transfected with FasL were rejected by MRL/+ and MRL/gld mice. Conclusion: Mast cells abrogate the rejection of MRL/N-1 tumor cells and that this tumor rejection is mediated by CD8+ T cells and dependent on host Fas-FasL axis.

  18. Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization

    Directory of Open Access Journals (Sweden)

    Isayama Teruto

    2010-11-01

    Full Text Available Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluorescence in situ hybridization (M-FISH, Urovysion™ FISH, and comparative genomic hybridization (CGH for the characterization of chromosomal aberrations. FU-MFH-2 cells were spindle or polygonal in shape with oval nuclei, and were successfully maintained in vitro for over 80 passages. The histological features of heterotransplanted tumors in severe combined immunodeficiency mice were essentially the same as those of the original tumor. Cytogenetic and M-FISH analyses displayed a hypotriploid karyotype with numerous structural aberrations. Urovysion™ FISH revealed a homozygous deletion of the p16INK4A locus on chromosome band 9p21. CGH analysis showed a high-level amplification of 9q31-q34, gains of 1p12-p34.3, 2p21, 2q11.2-q21, 3p, 4p, 6q22-qter, 8p11.2, 8q11.2-q21.1, 9q21-qter, 11q13, 12q24, 15q21-qter, 16p13, 17, 20, and X, and losses of 1q43-qter, 4q32-qter, 5q14-q23, 7q32-qter, 8p21-pter, 8q23, 9p21-pter, 10p11.2-p13, and 10q11.2-q22. Conclusion The FU-MFH-2 cell line will be a particularly useful model for studying molecular pathogenesis of human pleomorphic MFH.

  19. Retroperitoneal angiomatoid fibrous histiocytoma: A case report and review of the literature

    OpenAIRE

    XIANG, LILI; ZHOU, JIAHE; Gu, Weiying; Yang, Bin

    2013-01-01

    Angiomatoid fibrous histiocytoma (AFH) is a rare, low-grade malignant potential soft tissue tumor which occurs most commonly in children and young adults. Only a few case reports have been described that typically occur in the extremities of the deep dermis and subcutaneous tissue, followed by the trunk, as well as the head and neck. A case report of retroperitoneal AFH is described. This presentation for patients with AFH has not yet been reported. AFH may occur in the retroperitoneum, in th...

  20. Angiomatoid fibrous histiocytoma in a 25-year-old male

    Directory of Open Access Journals (Sweden)

    David Dingli

    2010-06-01

    Full Text Available Angiomatoid fibrous histiocytoma (AFH is a rare disease that is often misdiagnosed initially. Patients can present with a clinical picture concerning for other diseases, and pathologic review is not always revealing. Molecular diagnostics are increasingly being utilized to detect gene fusions characteristic for AFH. Surgery remains the mainstay of management, and can effectively control local recurrences and metastases. Herein we describe a case report of a 25-year-old gentleman whose presentation was concerning for lymphoma. Subsequently we review of the relevant literature.

  1. Benign fibrous histiocytoma of the nasal cavity in a newborn: MR and CT findings.

    Science.gov (United States)

    Shrier, D A; Wang, A R; Patel, U; Monajati, A; Chess, P; Numaguchi, Y

    1998-01-01

    Benign fibrous histiocytoma of the nasal cavity in a newborn is rare, and the MR imaging appearance of this entity has not been reported. We present the MR and CT findings in such a case and review the differential diagnosis for intranasal masses in the neonate. PMID:9672033

  2. Malignant solitary fibrous tumor involving the liver

    OpenAIRE

    Manuel Jakob; Matthias Schneider; Ingo Hoeller; Urban Laffer; Reto Kaderli

    2013-01-01

    Solitary fibrous tumors are predominantly benign and are most commonly found in the thoracic cavity and pleura; while reports exist in the literature of malignant solitary fibrous tumors and those located in extrathoracic organs, these cases are considered extremely rare. Herein, a case is reported of a malignant solitary fibrous tumor involving the liver that was diagnosed and treated in a 62-year-old woman. The patient presented with complaints of upper abdominal pain and unintentional weig...

  3. Deep benign fibrous histiocytoma: computed tomography and histology findings; Histiocitoma fibroso benigno profundo: achados na tomografia computadorizada e histologia

    Energy Technology Data Exchange (ETDEWEB)

    Farage, Luciano; Castro, Mario Augusto Padula; Macedo, Tulio Augusto Alves [Uberlandia Univ., MG (Brazil). Hospital das Clinicas. Setor de Radiologia; Salomao, Eliana Chaves; Machado, Tania Alcantara; Souza, Lincoln Pereira de; Freitas, Luiz de Oliveira [Uberlandia Univ., MG (Brazil). Faculdade de Medicina. Dept. de Clinica Medica

    2005-04-01

    We present the computed tomography images of an 83-year-old male patient with a deep benign fibrous histiocytoma at the lateral aspect of the left leg. Computed tomography images showed a well-defined mass with marked peripheral enhancement by iodinated contrast medium. Only few reports of this rare soft tissue tumor can be found in the literature. (author)

  4. Malignant solitary fibrous tumor involving the liver.

    Science.gov (United States)

    Jakob, Manuel; Schneider, Matthias; Hoeller, Ingo; Laffer, Urban; Kaderli, Reto

    2013-06-01

    Solitary fibrous tumors are predominantly benign and are most commonly found in the thoracic cavity and pleura; while reports exist in the literature of malignant solitary fibrous tumors and those located in extrathoracic organs, these cases are considered extremely rare. Herein, a case is reported of a malignant solitary fibrous tumor involving the liver that was diagnosed and treated in a 62-year-old woman. The patient presented with complaints of upper abdominal pain and unintentional weight loss. Computed tomography scan of the abdomen revealed a remarkably large mass, measuring 15 cm × 10 cm × 20 cm, which appeared to be unrelated to any particular organ. The intraoperative finding of a wide communication with the left liver suggested hepatic origin, and served as an indicator for tumor resection via left hemihepatectomy. The diagnosis of solitary fibrous tumor and its malignant nature was confirmed by histological and immunohistochemical examination of the resected tissues. Hepatic solitary fibrous tumor is very rare, and surgery remains the mainstay of treatment. Due to limited reports of such tumors in the literature, little can be said about the benefit of adjuvant therapy and prognosis for the rare cases with malignant histological findings. PMID:23745040

  5. Malignant solitary fibrous tumor involving the liver

    Directory of Open Access Journals (Sweden)

    Manuel Jakob

    2013-01-01

    Full Text Available Solitary fibrous tumors are predominantly benign and are most commonly found in the thoracic cavity and pleura; while reports exist in the literature of malignant solitary fibrous tumors and those located in extrathoracic organs, these cases are considered extremely rare. Herein, a case is reported of a malignant solitary fibrous tumor involving the liver that was diagnosed and treated in a 62-year-old woman. The patient presented with complaints of upper abdominal pain and unintentional weight loss. Computed tomography scan of the abdomen revealed a remarkably large mass, measuring 15 cm × 10 cm × 20 cm, which appeared to be unrelated to any particular organ. The intraoperative finding of a wide communication with the left liver suggested hepatic origin, and served as an indicator for tumor resection via left hemihepatectomy. The diagnosis of solitary fibrous tumor and its malignant nature was confirmed by histological and immunohistochemical examination of the resected tissues. Hepatic solitary fibrous tumor is very rare, and surgery remains the mainstay of treatment. Due to limited reports of such tumors in the literature, little can be said about the benefit of adjuvant therapy and prognosis for the rare cases with malignant histological findings.

  6. Fibrohistiocitoma conjuntival simulando pterígio atípico na região amazônica: relato de caso / Conjunctival fibrous histiocytoma simulating atipical pterygium in the Amazon region: case report

    Scientific Electronic Library Online (English)

    Roberto Murillo Limongi de Souza, Carvalho; Alexandre, Taleb; Giulianna Limongi de Souza, Carvalho; Marcos, Ávila.

    2010-12-01

    Full Text Available Relatamos um caso inédito na literatura brasileira de fibrohistiocitoma conjuntival descoberto durante projeto comunitário de larga escala realizado pela equipe do Centro de Referência em Oftalmologia do Hospital das Clínicas da Universidade Federal de Goiás na região amazônica. Paciente do sexo fem [...] inino, leucoderma, de 38 anos de idade, apresentava lesão vascularizada no olho direito no canto medial da conjuntiva bulbar e carúncula com extensão para o limbo e invadindo cerca de 2 mm da córnea medial com configuração semelhante a um pterígio. O exame histopatológico revelou lesão constituída por células fusiformes, com arranjo estoriforme e células histiocitárias gigantes. A imunohistoquímica revelou forte positividade para vimentina e as células neoplásicas foram negativas para AE1/ AE3, HMB 45, proteína S 100. O diagnóstico histopatológico foi de fibrohistiocitoma. A evolução poderá demonstrar o crescimento tumoral e a possibilidade de lesão maligna. Abstract in english An inedited case in the Brazilian literature of conjunctival fibrous histiocytoma discovered during a wide scale community project accomplished by the team of the Center of Reference in Ophthalmology of the Hospital das Clínicas da Universidade Federal de Goiás in the Amazon region is reported. A 38 [...] year-old caucasian woman presented with a vascularized lesion on the medial portion of the bulbar conjunctiva and caruncular region of the right eye with extension for the limbus and invading about 2 mm of the medial cornea resembling a pterygium. Pathologic findings revealed that the lesion was constituted by spindle-shaped cells, with storiform arrangement, and large histocytelike cells. The immunohistochemistry revealed strong positivity for vimentin and the neoplastic cells were negative for AE1/AE3, HMB 45, S 100 protein. The histopathologic diagnosis was fibrous histiocytoma. The evolution demonstrated the tumoral growth and the possibility of a malignant lesion.

  7. Paraneoplastic Syndrome of Angiomatoid Fibrous Histiocytoma May Be Caused by EWSR1-CREB1 Fusion-induced Excessive Interleukin-6 Production.

    Science.gov (United States)

    Akiyama, Masaharu; Yamaoka, Masayoshi; Mikami-Terao, Yoko; Yokoi, Kentaro; Inoue, Takashi; Hiramatsu, Tomomasa; Ashizuka, Shuichi; Yoshizawa, Jyoji; Katagi, Hiroaki; Ikegami, Masahiro; Ida, Hiroyuki; Nakazawa, Atsuko; Okita, Hajime; Matsumoto, Kenji

    2015-10-01

    We describe a 7-year-old girl with angiomatoid fibrous histiocytoma (AFH) presenting severe inflammatory symptoms. The cytokine/chemokine profile of serum samples before and after surgery demonstrated that interleukin (IL)-6 had decreased by the greatest percentage. The AFH cells were immunopathologically positive for IL-6 and Tyr705-phosphorylation of signal transducer and activator of transcription 3. The EWSR1-CREB1 fusion gene detected in the tumor leads to continuous activation of CREB1 and IL-6 production, because the promoter region of IL-6 has a CREB binding site. Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH. PMID:26165403

  8. Reconstruction of the pelvic ring using an autologous free non-vascularized fibula graft in a patient with benign fibrous histiocytoma

    Directory of Open Access Journals (Sweden)

    Werner Mathias

    2004-11-01

    Full Text Available Abstract Background Benign fibrous histiocytomas (BFH usually presents as a small benign lesion that predominantly occurs in the skin. Only few cases of BFH arising from bone have been reported, its occurrence in pelvic bones is even rarer. Case presentation A 34-year-old female presented with BFH at a rare anatomical location on both sides of the os ilium which was larger than earlier reported BFH of the bone. Surgical resection was performed successfully including resection of the inner pelvic ring and reconstruction of the linea terminalis using a non-vascularized fibular autograft. At 18 months after tumor resection and reconstruction of the pelvic ring, with interposition of a free vascularized fibula graft patient has an excellent clinical oncological and functional outcome. Conclusion Non vascularized fibular autograft is a useful reconstructive procedure in select patients.

  9. Correlation imaging findings of primary malignant fibrous histioctoma of bone with pathology

    International Nuclear Information System (INIS)

    Objective: To explore the imaging features of primary malignant fibrous histiocytoma (MFH) of bone and correlate them with pathological findings. Methods: Thirteen cases patients with primary MFH of bone confirmed by surgical pathology underwent radiography, spiral CT plain scanning and MR SE-TWI, T2WI and SE-T1WI enhancement scanning before operation. The imaging date was reviewed and analysed retrospectively in comparison with surgical and pathological results. Results: Of 13 MFH, 11 were located in the end of long bone, and 2 in the diaphysis. The distance between tumors in the end of long bone and adjacent joint surface was 1 to 5 cm. All lesions showed osteolytic destruction with the maximum diameter of the tumors from 5.3 to 12.7 cm. The tumors had eccentric aggressive osteolytic destruction in 10 lesions, internal crest within the lesions in 7, inconsecutive marginal osteosclerosis in 11, little periosteal reaction in 2 and small soft tissue masses in 9, respectively. The CT value of lesions was similar to muscle. MR imaging depicted low signal intensity with aggressive features on T1WI, iso to slight high signal intensity on T2WI, and middle or high degree contrast enhancement on enhanced T1WI images. Macroscopically, MFH was usually located eccentrically within the bone and produced little or no osseous expansion. The soft tissue component appeared multi-nodules and pseudo-encapsulated. Histologically, they consisted of spindle-shaped fibroblasts, which radiated outward in a spiral array from a central focus and produced a nebula or storiform appearance, and cells, which were small and oval with little visible cytoplasm. Conclusions: The imaging manifestations of MFH were specific to some extent. Combined utilization of plain X-ray, CT, and MRI is helpful for the diagnosis and differential diagnosis of MFH. (authors)

  10. Malignant fibrous histiocytoma presenting with complete opacification of the hemithorax: A case report

    Directory of Open Access Journals (Sweden)

    Jean Salem

    2014-01-01

    CONCLUSION: Progressive dyspnea in young otherwise healthy patients should be investigated early on. In our case the presence of right shoulder pain indicates advance disease illustrated by the singular imaging findings.

  11. Unusual malignant solid neoplasms of the kidney: Cross-sectional imaging findings

    International Nuclear Information System (INIS)

    Malignant kidney neoplasms are the most frequently encountered solid kidney masses. Although renal cell carcinoma is the major renal malignancy, other solid malignant renal masses should be considered in the differential diagnosis of solid renal masses that do not contain a macroscopic fatty component. In this pictorial essay, we present the imaging findings of a primitive neuroectodermal tumor, primary liposarcoma of the kidney, primary neuroendocrine tumor, leiomyosarcoma, synovial sarcoma, malignant fibrous histiocytoma, sclerosing fibrosarcoma and renal metastasis of osteosarcoma

  12. Unusual malignant solid neoplasms of the kidney: Cross-sectional imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Karaosmanoglu, Ali Devrim; Hahn, Peter F. [Dept. of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston (United States); Shirkhoda, Ali [Dept. of Radiology, University of California School of Medicine, Irvine (United States); Onur, Mehmet Ruhi; Ozmen, Mustafa [Dept. of Radiology, University of Hacettepe School of Medicine, Ankara (Turkmenistan)

    2015-08-15

    Malignant kidney neoplasms are the most frequently encountered solid kidney masses. Although renal cell carcinoma is the major renal malignancy, other solid malignant renal masses should be considered in the differential diagnosis of solid renal masses that do not contain a macroscopic fatty component. In this pictorial essay, we present the imaging findings of a primitive neuroectodermal tumor, primary liposarcoma of the kidney, primary neuroendocrine tumor, leiomyosarcoma, synovial sarcoma, malignant fibrous histiocytoma, sclerosing fibrosarcoma and renal metastasis of osteosarcoma.

  13. Primary malignant bone tumors: diagnosis, radiological appearance and therapy

    International Nuclear Information System (INIS)

    Diagnosis, concepts of therapy and prognosis of primary malignant bone tumors require intensive cooperation between orthopedic surgeons, radiologists and pathologists with special knowledge in oncology. The present paper demonstrates relevant topics of diagnosis, radiological appearance and therapy of the osteosarcoma, Ewing's sarcoma, chondrosarcoma and malignant fibrous histiocytoma based on the material of the Vienna Bone Tumor Registry and more than 35 years of cooperation between the Institute of Pathology and Anatomy and the Department of Orthopedics at the University of Vienna. (orig.)

  14. Malignant mesenchymatous tumor of the abdominal cavity

    Directory of Open Access Journals (Sweden)

    K.S. Atmatzidis, T.E. Pavlidis, I.N. Galanis, B.T. Papaziogas, T.B. Papaziogas

    2007-03-01

    Full Text Available SUMMARY Malignant fibrous histiocytoma (MFH represents a soft tissue sarcoma originating from fibroblast cells, and is characterized by a high rate of metastasis or recurrence. The development of this tumor in the gastrointestinal tract is a very rare entity. No more than 30 cases are described in the litrature. We report on a case of such tumor of the abdominal cavity in a 45 year-old woman, presented with epigastric pain, anorexia and weight loss. The CT-scanning revealed the presence of multiple solid tumors in the peritoneal cavity. On the exploratory laparotomy at least 15 solid whitish tumors were found, attached to the wall of the small intestine, as well as to the parietal peritoneum. In addition, there were three metastases revealed in the liver. All tumors were excised; most of them were about 10 cm in diameter. The histopathologic study indicated the presence of a stromal tumor consisting of spindle cells. The consequent immuno- histo-chemical examination of the resected specimens established the definite diagnosis of a pleomorphic malignant fibrous histiocytoma. The postoperative course of the patient was uneventful. She received adjuvant chemotherapy and is still alive and in good health two years later. Key words: malignant fibrous histiocytoma, soft tissue tumors, stromal tumors, sarcomas, storiform-pleomorphic lesions.

  15. Renal malignant solitary fibrous tumor with single lymph node involvement: report of unusual metastasis and review of the literature

    Directory of Open Access Journals (Sweden)

    Mearini E

    2014-05-01

    Full Text Available Ettore Mearini,1 Giovanni Cochetti,1 Francesco Barillaro,1 Sonia Fatigoni,2 Fausto Roila2 1Department of Medical-Surgical Specialties and Public Health, Division of Urological Andrological Surgery and Minimally Invasive Techniques, University of Perugia, Terni, Italy; 2Medical Oncology, S Maria Hospital, Terni, Italy Abstract: Solitary fibrous tumors are rare mesenchymal spindle cell neoplasms that are usually found in the pleura. The kidneys are an uncommon site and only few cases of renal solitary fibrous tumor exhibit malignant behavior metastasizing to the liver, lung, and bone through the hematogenous pathway. Purpose: To describe the first case of lymph node metastasis from renal solitary fibrous tumor in order to increase the knowledge about the malignant behavior of these tumors. Patients and methods: A 19-year-old female patient had intermittent hematuria for several months without flank pain or other symptoms. A chest and abdomen CT scan was performed and showed a multi-lobed bulky solid mass of 170 × 98 × 120 mm in the left kidney. One day before the surgery, the left renal artery was catheterized and the kidney embolization was performed using a Haemostatic Absorbable Gelatin Sponge and polyvinyl alcohol. We then performed a radical nephrectomy with hilar, para-aortic, and inter-aortocaval lymphadenectomy. Results: Estimated intraoperative blood loss was 200 mL and the operative time was 100 minutes. No postoperative complications occurred. The hospital stay was 7 days long. The histological examination was malignant solitary fibrous tumor of the kidney. Cancerous tissue showed cellular atypia, with an increased mitotic index (up to 7 × 10 hpf. Immunohistochemical analysis showed positive results for CD34, BCL2, partial expression of HBME1, and occasionally of synaptophysin. Histological evaluation confirmed the presence of metastasis in one hilar node. The patient did not receive any other therapy. At 30-month follow-up, the patient was in good health and no local recurrence or metastases had occurred. Conclusion: This is the first case of lymph node metastasis from a renal solitary fibrous tumor showing unusual malignant behavior; this finding adds new information about the biology and progression of these tumors, which remain unclear. Keywords: solitary fibrous tumor, sarcoma, kidney, lymph node metastases, lymphadenectomy

  16. Doege-Potter syndrome presenting with hypoinsulinemic hypoglycemia in a patient with a malignant extrapleural solitary fibrous tumor: a case report

    OpenAIRE

    Schutt Robert C; Gordon Trish A; Bhabhra Ruchi; Cathro Helen P; Cook Stephen L; McCartney Christopher R; Weiss Geoffrey R

    2013-01-01

    Abstract Introduction Doege-Potter syndrome is a paraneoplastic syndrome characterized by non-islet cell tumor hypoglycemia secondary to a solitary fibrous tumor. This tumor causes hypoglycemia by the secretion of a prohormone form of insulin-like growth factor II. We describe the diagnosis and management of Doege-Potter syndrome and the use of transarterial chemoembolization in a patient with a malignant extrapleural solitary fibrous tumor. Case presentation Our patient was a 64-year-old Cau...

  17. Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas

    DEFF Research Database (Denmark)

    Jensen, V; Sørensen, Flemming Brandt; Bentzen, S M; Ladekarl, M; Nielsen, O S; Keller, J; Jensen, O M

    1998-01-01

    AIMS: To evaluate the prognostic value of tumour proliferative activity, p53 accumulation and bcl-2 expression in a retrospective series of 216 patients with soft tissue sarcomas (STS). METHODS AND RESULTS: The immunohistochemical analyses were performed on formalin-fixed, paraffin-embedded tissue. The proliferative activity was assessed by use of the monoclonal antibody MIB-1 and evaluated in multiple, random systematic sampled fields of vision. The percentage of proliferating cells (the MIB-1 ...

  18. Case report 394: Malignant fibrous histocytoma (MFH) arising in an infarct of bone

    International Nuclear Information System (INIS)

    A case is presented of a 56-year-old white woman, who was symptomatic for one year with pain over the medial aspect of lower portion of the left thigh. Radiological studies demonstrated multiple areas of infarction in the distal end of the left femur and upper end of the left tibia. The right femur and the right tibia were similarly affected. Four months later an obvious change had occurred in the left femur, with development of a large osteolytic lesion with breakthrough of the cortex into the soft tissues. A soft tissue mass was present and a Codman triangle also was noted, indicating malignant disease. CT studies confirmed these features as did a radionuclide examination using Tc-MDP. The osteolytic lesion superimposed on the infarct of the left femur proved to be an MFH - a transformation from an infarct of bone which has been reported a number of times previously. Some speculation was included regarding the pathogenesis of the development of a sarcomatous process from an underlying infarct of bone. A thorough but concise description of the entity of MFH in both its primary and secondary forms was included. (orig.)

  19. Doege-Potter syndrome presenting with hypoinsulinemic hypoglycemia in a patient with a malignant extrapleural solitary fibrous tumor: a case report

    Directory of Open Access Journals (Sweden)

    Schutt Robert C

    2013-01-01

    Full Text Available Abstract Introduction Doege-Potter syndrome is a paraneoplastic syndrome characterized by non-islet cell tumor hypoglycemia secondary to a solitary fibrous tumor. This tumor causes hypoglycemia by the secretion of a prohormone form of insulin-like growth factor II. We describe the diagnosis and management of Doege-Potter syndrome and the use of transarterial chemoembolization in a patient with a malignant extrapleural solitary fibrous tumor. Case presentation Our patient was a 64-year-old Caucasian woman who initially presented with urinary incontinence and was found to have a 14.5×9.0×9.0cm retroperitoneal solitary fibrous tumor compressing her bladder. Her tumor was surgically resected but recurred with multiple hepatic metastatic lesions. The hepatic metastases progressed despite systemic chemotherapy and treatment with doxorubicin transarterial chemoembolization. Her course was complicated by the development of recurrent fasting hypoglycemia, most likely secondary to Doege-Potter syndrome. Her hypoglycemia was managed with corticosteroid therapy and frequent scheduled nutrient intake overnight. Conclusions The rarity of hepatic solitary fibrous tumors and consequent lack of controlled trials make this report significant in that it describes the diagnostic approach to Doege-Potter syndrome, describes our experience with the use of doxorubicin transarterial chemoembolization, and presents management options for tumor-associated hypoglycemia in the case of extensive disease not amenable to surgical resection.

  20. Cytogenetic and molecular-genetic aberrations in malignant primary bone tumors

    International Nuclear Information System (INIS)

    Osteosarcoma, chondrosarcoma and tumors of the Ewing group are the most frequently observed primary malignant bone tumors. In an Internet homepage recently constructed for the Orthopedic Hospital Rizzoli Bologna, Italy, these tumors have represented the majority of 4423 malignant bone tumors in the archives of this institution since 1920 (http://www.tizeta.it/rizzoli). Malignant fibrous histiocytoma, fibrosarcoma, hemangioendothelioma, malignant hemangiopericytoma and giant-cell tumors are diagnosed less frequently. Since the introduction of modern molecular and cytogenic techniques, knowledge of genetic aberrations in malginant bone tumors has steadily increased. However, so far only for the group of Ewing tumors has a recurrent chromosomal marker, the translocation t(11; 22)(q24; q12), been identified. (orig.)

  1. [Morphology and molecular biology of malignant soft tissue sarcomas].

    Science.gov (United States)

    Katenkamp, D

    1998-08-19

    Malignant soft tissue tumors are classified and named according to cellular differentiation and thus the non-neoplastic soft tissue they imitate. The topical WHO classification already comprises more than 140 entities and tumor subtypes, but the process of defining new tumor variants will go on. Questions of nomenclature are discussed briefly with laying special emphasis on the non-undisputed concept of malignant fibrous histiocytomas. Without doubt, this diagnosis is made too frequently by which it has become to a collective name for unclassifiable pleomorphic sarcomas. For the time being nobody is able to say whether or not the malignant fibrous histiocytoma will remain an entity. Likely, fibrosarcomas and hemangiopericytomas are defined as exclusion diagnosis, as well. The diagnosis of malignant soft tissue tumors is based on recognizing the cellular line of differentiation. This is frequently possible at light microscopic level, sometimes additional diagnostic methods are required. The most important adjunct method is immunohistochemistry. Because aberrant differentiations and unexpected immunohistochemical reactions are known the use of a panel of antibodies is necessary. In the last years soft tissue tumors has increasingly been characterized by molecular biological methods. The results are of significance for understanding sarcoma pathogenesis and may be used for diagnosis, as well. Chromosome translocations are explained and rhabdomyosarcomas are taken as example for demonstrating the diagnostic significance of molecular biological/cytogenetic findings. Molecular biology may also aid in defining the histopathologic features of an entity as shown for intraabdominal desmoplastic small cell tumors. Eventually, heterogeneity in soft tissue sarcomas is addressed and discussed in view of its importance for diagnosis, classification and therapy as well as for development of sarcoma progression. PMID:9757787

  2. Accumulation of leucocytes labelled with technetium-99m hexamethylpropylene amine oxime in malignant abdominal tumours

    Energy Technology Data Exchange (ETDEWEB)

    Lantto, E. (Paeijaet-Haeme Central Hospital, Lahti (Finland). Dept. of Radiology); Jaervi, K. (Paeijaet-Haeme Central Hospital, Lahti (Finland). Dept. of Pathology); Lantoo, T.; Vorne, M. (Paeijaet-Haeme Central Hospital, Lahti (Finland). Dept. of Nuclear Medicine); Ristkari, S. (Paeijaet-Haeme Central Hospital, Lahti (Finland). Dept. of Surgery)

    1991-10-01

    A total of 343 leucocyte scans labelled with technetium-99m hexamethylprophylene amine oxime were reviewed that had been performed patients suspected of having abdominal infection or inflammation. There was uptake by malignant abdominal tumours in 10 cases (2,9%), which represents 62.5% of known malignancies at the time of the scintigram. Accumulation was seen in 8 patients with adenocarcinoma of the colon associated with a secondary infection in the tumour or pericolic inflammation. A large tumour that had spread beyond the bowel wall was related to a positive scintigram. Accumulation was also found twice in a malignant fibrous histiocytoma in which bleeding and an inflammatory reaction to necrosis were probably responsible for the uptake. The relevant treatment was delayed for 2 weeks-2 months in 4 patients with adenocarcinoma of the colon in whom the positive uptake was regarded as confirmation of the clinically suspected cute diverticulitis. (orig.).

  3. Renal malignant solitary fibrous tumor with single lymph node involvement: report of unusual metastasis and review of the literature

    OpenAIRE

    Mearini E; Cochetti G; Barillaro F; Fatigoni S; Roila F

    2014-01-01

    Ettore Mearini,1 Giovanni Cochetti,1 Francesco Barillaro,1 Sonia Fatigoni,2 Fausto Roila2 1Department of Medical-Surgical Specialties and Public Health, Division of Urological Andrological Surgery and Minimally Invasive Techniques, University of Perugia, Terni, Italy; 2Medical Oncology, S Maria Hospital, Terni, Italy Abstract: Solitary fibrous tumors are rare mesenchymal spindle cell neoplasms that are usually found in the pleura. The kidneys are an uncommon site and only few cases of renal ...

  4. [Diabetic fibrous mastopathy].

    Science.gov (United States)

    Kribi, L; Chelli, M; Sellami, D; Ellouze, T; Tenzekhti, F; Mnif, N; Hamza, R

    1999-11-01

    Diabetic fibrous mastopathy was first described in 1984. This mastopathy usually occurs in patients with autoimmune disorders and often occurs in patients with insulin-dependent diabetes. Little is known about this benign condition. Clinically and radiologically, this entity may simulate malignancy. The presence of an underlying auto-immune disorder or diabetes may suggest the correct diagnosis. The authors report two cases of fibrous mastopathy and suggest that core biopsy could replace surgical biopsy for diagnosis. PMID:10592917

  5. Special diagnostic problems in primary malignant bone tumors

    International Nuclear Information System (INIS)

    The diagnosis of primary malignant bone tumors, which only account for 1% of malignancies in humans, represents quite a challange for the pathologist. Apart from the often overlapping morphology between different entities, heterogeneity within one and the same tumor has to be kept in mind. Furthermore, in most cases the diagnosis must be established based on small biopsy specimens and occasionally even on frozen sections. In this context detailed clinical information including the patient's age and exact localization of the tumor, as depicted by X-ray or MRI, are essential requirements for a correct diagnosis. In addition, multiple biopsies from different tumor sites may be of help. For example, 25% of osteogenic sarcomas (OSA) are chondroplastic. Others may contain areas similar to fibrosarcoma (FSA) or malignant fibrous histiocytoma (MFH). Since 90% of OSA occur in the second decade of life whereas chondrosarcomas, FSA and MFH usually manifest after the age of 40 years, a biopsy solely composed of malignant chondromatous tissue obtained from a tibial lesion of a 10-year-old child should most likely be considered as part of an OSA. In the differential diagnosis of the so-called small, round cell tumors, which include Ewing sarcoma, malignant lymphoma and small-cell OSA, immunohistochemical staining of the paraffin-embedded material and a molecular biological/genetic work-up of frozen material are most helpful. In this paper the histomorphological characteristics and criteria for differential diagnosis of the most common primary malignant bone tumors are discussed. (orig.)

  6. Spontaneous malignant transformation of conventional giant cell tumor

    Energy Technology Data Exchange (ETDEWEB)

    Grote, H.J.; Pomjanski, N.; Boecking, A. [Institute of Cytopathology, Heinrich Heine University, Moorenstrasse 5, 40225, Duesseldorf (Germany); Braun, M. [Orthopedic Hospital Volmarstein, University of Witten/Herdecke, Hartmannstrasse 24, 58300, Wetter (Ruhr) (Germany); Kalinski, T.; Roessner, A. [Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, 39120, Magdeburg (Germany); Back, W.; Bleyl, U. [Department of Pathology, Ruprecht Karls University Heidelberg, University Hospital Mannheim, Theodor-Kutzer-Ufer, 68167, Mannheim (Germany)

    2004-03-01

    Spontaneous malignant transformation of conventional giant cell tumor (GCT) of bone is exceedingly rare. We report on a case of GCT of the iliac crest in a 35-year-old woman with malignant change into a high-grade osteosarcoma 10 years after the first appearance of GCT on a radiograph. Since the patient refused therapy for personal reasons the tumor remained untreated until sarcomatous transformation occurred. Image cytometry showed DNA aneuploidy and a suspiciously high 2c deviation index (2cDI) in the primary bone lesion. A thorough review of the world literature revealed only seven fully documented cases of secondary malignant GCT which matched the definition of a ''sarcomatous growth that occurs at the site of a previously documented benign giant cell tumor'' and not treated by radiotherapy. These cases as well as the current one suggest that a spontaneous secondary malignant GCT presents as a frankly sarcomatous tumor in the form of an osteosarcoma or malignant fibrous histiocytoma. It usually appears at sites of typical GCTs - often without any recurrent intermediate state - and is diagnosed 3 or more years after the primary bone lesion. The prognosis is poor. (orig.)

  7. Spontaneous malignant transformation of conventional giant cell tumor

    International Nuclear Information System (INIS)

    Spontaneous malignant transformation of conventional giant cell tumor (GCT) of bone is exceedingly rare. We report on a case of GCT of the iliac crest in a 35-year-old woman with malignant change into a high-grade osteosarcoma 10 years after the first appearance of GCT on a radiograph. Since the patient refused therapy for personal reasons the tumor remained untreated until sarcomatous transformation occurred. Image cytometry showed DNA aneuploidy and a suspiciously high 2c deviation index (2cDI) in the primary bone lesion. A thorough review of the world literature revealed only seven fully documented cases of secondary malignant GCT which matched the definition of a ''sarcomatous growth that occurs at the site of a previously documented benign giant cell tumor'' and not treated by radiotherapy. These cases as well as the current one suggest that a spontaneous secondary malignant GCT presents as a frankly sarcomatous tumor in the form of an osteosarcoma or malignant fibrous histiocytoma. It usually appears at sites of typical GCTs - often without any recurrent intermediate state - and is diagnosed 3 or more years after the primary bone lesion. The prognosis is poor. (orig.)

  8. FDG-PET for preoperative differential diagnosis between benign and malignant soft tissue masses

    Energy Technology Data Exchange (ETDEWEB)

    Aoki, J.; Koyama, Y.; Sato, N. [Department of Diagnostic Radiology, Gunma University School of Medicine, 3-39-22 Showa-machi, 371-8511, Maebashi (Japan); Watanabe, H.; Shinozaki, T.; Takagishi, K. [Department of Orthopaedic Surgery, Gunma University School of Medicine, 3-39-22 Showa-machi, 371-8511, Maebashi (Japan); Tokunaga, M. [Department of Diagnostic Radiology, Gunma University School of Medicine, 3-39-22 Showa-machi, 371-8511, Maebashi (Japan); Department of Radiology, Ohta General Hospital (Japan); Endo, K. [Department of Diagnostic Radiology, Gunma University School of Medicine, 3-39-22 Showa-machi, 371-8511, Maebashi (Japan); Department of Nuclear Medicine, Gunma University School of Medicine, 3-39-22 Showa-machi, 371-8511, Maebashi (Japan)

    2003-03-01

    To evaluate the standardized uptake value (SUV) of [{sup 18}F]2-deoxy-2-fluoro-d-glucose at positron emission tomography (FDG-PET) for preoperative differential diagnosis between benign and malignant soft tissue masses.Design One hundred and fourteen soft tissue masses (80 benign, 34 malignant) were examined by FDG-PET prior to tissue diagnosis. The SUVs were calculated and compared between benign and malignant lesions and among different histologic subgroups which included three or more cases. There was a statistically significant difference in SUV between benign (1.80{+-}1.42 [SD]) and malignant (4.20{+-}3.16) soft tissue masses in total (P<0.0001). However, a considerable overlap in SUV was observed between many benign and malignant lesions. Liposarcomas (2.16{+-}1.72) and synovial sarcomas (1.60{+-}0.43) did not show significantly higher SUV than any benign lesions. Metastases (4.23{+-}2.35) showed no statistically significant difference in SUV as compared with schwannomas (1.75{+-}0.84), desmoids (2.77{+-}1.32), sarcoidosis (3.62{+-}1.53), or giant cell tumors of tendon sheath (GCT of TS; 5.06{+-}1.63). Even malignant fibrous histiocytomas (5.37{+-}1.40) could not be differentiated from sarcoidosis or GCT of TS, based on the SUV. A large accumulation of FDG can be observed in both benign and malignant histiocytic, fibroblastic, or neurogenic lesions. SUV at conventional FDG-PET is limited to differentiating benign from malignant soft tissue masses, when all kinds of histologic subtypes are included. (orig.)

  9. Prevalence of Malignant Soft Tissue Tumors inExtremities: An Epidemiological Study in Syria

    Directory of Open Access Journals (Sweden)

    Habib Reshadi

    2014-06-01

    Full Text Available Background:   Although the majority of soft tissue masses are benign, it is important to consider malignancy in differential diagnoses. Because most soft tissue sarcomas present as a painless mass, clinicians must watch for signs suggestive of malignancy, including large size, rapid growth, and site deep into the deep fascia.The purpose of this study was to determine the relative prevalence according to sex and age, site of tumor, skeletal distribution, and treatment (surgery, chemotherapy and radiotherapy before and after surgery, and ascertain the relative frequency of these tumors in specific anatomic sites and age groups based on pathological studies. Methods: A total of 308 patients, with a musculoskeletal tumor were evaluated retrospectively. All of the patients enrolled into this study were referred to the Beirouni Hospital of Damascus University with a proven diagnosis of alignant soft tissue tumors from the beginning of January 2008 until the end of 2010. The prevalence of the malignant soft tissue tumors in these patients was analyzed. For purposes of analysis, all lesions were placed in 1 of 9 categories: hand and wrist, forearm, humorous (arm, proximal limb girdle (axilla and shoulder, foot and ankle, thigh, hip and buttocks region, trunk, and other lesions. Age and sex also were recorded. Results: Malignant tumors consisted of seven diagnostic categories: malignant fibrous histiocytoma (23%, liposarcoma (22%, rhabdomyosarcoma (9%, leiomyosarcoma (8%, malignant schwannoma (5%, dermatofibrosarcoma protuberans (5%, synovial sarcoma (10%, fibrosarcoma (13%, extraskeletal chondrosarcoma (1%, and extraskeletal Ewing sarcoma (4%. Conclusions: Despite the multitude of pathologic possibilities, most malignant soft-tissue tumors are classified into a small number of diagnoses. These may be further defined when the site of the lesion and the age of the patient are considered. Knowledge of tumor prevalence will assist radiologists in establishing a suitably ordered differential diagnosis when a soft-tissue tumor has a nonspecific radiologic appearance.    

  10. Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature / Tumor fibroso solitário maligno da tiroide: relato de caso e revisão da literatura

    Scientific Electronic Library Online (English)

    Wellington, Alves Filho; Renata Regina da Graça Lorencetti, Mahmoud; Daniel Marin, Ramos; Vergilius José Furtado de, Araujo-Filho; Patricia Picciarelli de, Lima; Claudio Roberto, Cernea; Lenine Garcia, Brandão.

    2014-06-01

    Full Text Available O tumor fibroso solitário (SFT) é uma neoplasia rara de células fusiformes que mais frequentemente envolve a pleura, raramente ocorrendo em áreas extratorácicas. Já foram descritos 26 casos de SFT da tiroide. Relatamos o caso de uma paciente de 60 anos de idade com um histórico de 8 meses de aumento [...] do pescoço associado à disfagia. A paciente foi submetida a uma hemitiroidectomia direita e foi diagnosticado um SFT de tiroide. A imuno-histoquímica mostrou resultados positivos para o marcador CD34, e o grande número de mitoses e a presença de atipia celular sugerem que o tumor era maligno. Em nosso conhecimento, este é o segundo caso de STF da tiroide maligno já relatado. Dada a rara ocorrência desses tumores, a indicação de tratamento adjuvante e o prognóstico são incertos. Recomenda-se o acompanhamento de longo prazo depois da ressecção cirúrgica. Abstract in english Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm that most often involves the pleura, rarely occurring in extra-thoracic locations. Twenty-six cases of SFT arising in the thyroid gland have been described. We report a case of a 60-year-old woman presenting an 8-month history of enla [...] rgement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisable.

  11. Fibrous dysplasia of bone: a clinicopathologic review

    Directory of Open Access Journals (Sweden)

    Mohan H

    2011-11-01

    Full Text Available Harsh Mohan1, Preeti Mittal1, Irneet Mundi1, Sudhir Kumar21Department of Pathology, 2Department of Orthopedics, Government Medical College, Sector 32, Chandigarh, IndiaAbstract: Fibrous dysplasia of the bones is an uncommon congenital skeletal disorder that is found equally in both genders and is not inherited. Its etiology has been linked to an activating mutation of Gs? and the downstream effects of the resultant increase in cAMP. Fibrous dysplasia is categorized as either monostotic or polyostotic, and may occur as a component of McCune-Albright syndrome or the rare Mazabraud syndrome. Long bones, skull bones, and ribs are the most commonly affected bones. The radiological picture is somewhat variable, including a ground-glass appearance, expansion of the bone, and sclerosis surrounding the lesion. Histologically, fibrous dysplasia shows irregularly-shaped trabeculae of immature, woven bone in a background of variably cellular, loosely arranged fibrous stroma. It may be complicated by pathologic fracture, and rarely by malignant transformation. This review examines interesting issues surrounding the etiology of fibrous dysplasia, its clinical and laboratory manifestations, radiological picture, utility of bone biopsy, gross and microscopic pathology, complications, and its differential diagnostic considerations.Keywords: fibrous dysplasia, McCune-Albright syndrome, monostotic form, polyostotic form

  12. A case of congenital solitary Langerhans cell histiocytoma.

    LENUS (Irish Health Repository)

    Ricciardo, Bernadette

    2012-02-01

    A newborn baby boy was referred to the Paediatric Dermatology Unit with a solitary asymptomatic nodule overlying his right nasolabial fold. Complete physical examination, full blood count, serum chemistry, liver function tests and baseline imaging were unremarkable. Histopathological examination showed an atypical dermal infiltrate of mononuclear cells that stained positive with CD1a and S100. A diagnosis of congenital solitary Langerhans cell histiocytoma was made. The lesion completely resolved by 4 months of age. The baby is now 15 months old and repeat systemic evaluation has remained normal.

  13. Congenital Fibrous Maxillomandibular Fusion

    OpenAIRE

    Bali, Rishi; Parveen SHARMA; Jain, Samit; Thapar, Deepti

    2010-01-01

    Congenital fibrous fusion of the jaws (synechiae) without any concomitant oral anomalies is a very rare malformation. Less than 40 cases have been documented in the literature. Early division of fibrous bands not only allows effective feeding but also prevents development of facial deformity. Here we present a case of congenital maxillomandibular fusion in a neonate.

  14. Steel Fibrous Concrete

    International Science & Technology Center (ISTC)

    The Construction of Reliable and Durable Structural Units for Energy Facilities, Transportation Facilities and Other Structures Subjected to the Action of a Variety of Conditions and Loads Using New Compound Material - Steel Fibrous Concrete

  15. Craniofacial fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Aakarsh Jhamb

    2012-01-01

    Full Text Available Fibrous dysplasia can present clinically in varied forms which may appear as collision of different pathologic processes. We report a rare case of craniofacial fibrous dysplasia with coexisting epithelial lined cyst and superimposed osteomyelitis with sequestrum formation. Its clinical features and management with possible hypotheses are described along with the post operative course. Pertinent literature has been reviewed with emphasis on pathogenesis of this unique occurrence.

  16. Strength of Fibrous Composites

    CERN Document Server

    Huang, Zheng-Ming

    2012-01-01

    "Strength of Fibrous Composites" addresses evaluation of the strength of a fibrous composite by using its constituent material properties and its fiber architecture parameters. Having gone through the book, a reader is able to predict the progressive failure behavior and ultimate strength of a fibrous laminate subjected to an arbitrary load condition in terms of the constituent fiber and matrix properties, as well as fiber geometric parameters. The book is useful to researchers and engineers working on design and analysis for composite materials. Dr. Zheng-Ming Huang is a professor at the School of Aerospace Engineering & Applied Mechanics, Tongji University, China. Mr. Ye-Xin Zhou is a PhD candidate at the Department of Mechanical Engineering, the University of Hong Kong, China.

  17. [About a case of calcifying fibrous tumor of the pleura].

    Science.gov (United States)

    Rocas, Delphine; Thivolet-Béjui, Françoise; Tronc, François; Chalabreysse, Lara

    2015-12-01

    Calcifying fibrous tumor is a rare soft tissue benign tumor (OMS 2002). Some pleural localisations are described, which affect slightly older individuals than the other soft tissue forms. The calcifying fibrous tumor is included in the 2004 World Health Organization classification of pleural tumors. A pleural tumor located in the right inferior pulmonary lobe is diagnosed in a 59-year-old man. This pleural tumor is macroscopically well-circumscribed. Histologically, the rare spindle tumoral cells are located between bundles of a collagenous tissue, sometimes hyalinized, with psammomatous or dystrophic calcifications. The tumoral cells have a fibrohistiocytic origin. They stain positively for antibodies against vimentin, factor XIIIa, CD68, CD163, CD34. Antibodies against smooth muscle actin, desmin, PS100, ALK1 and EBV are negative. Main differencial diagnoses are other benign pleural tumors (solitary fibrous tumor, inflammatory myofibroblastique tumor), some malignant tumors (desmoplastic malignant pleural mesothelioma) and pleural pseudotumors (calcified pleural plaques, chronic fibrous pleuritis, amylose, hyalinizing granuloma). Our case is the 15th pleural calcifying fibrous tumor being reported. PMID:26608111

  18. [Presence of lysozyme and alpha 1-antichymotrypsin in tumors of the fibrous histiocytoma type. Immunohistochemical evaluation of 52 cases].

    Science.gov (United States)

    Szklarski, W; Grucha?a, A; Ry?, J; Niezabitowski, A

    1989-01-01

    In 52 cases of fibrohistiocytic sarcoma activity of alfa-1-antichymotripsin (ACT) in tumour cells was found in 47 cases and lysozyme in 16 cases. ACT was found in all types of tumour except angiomatous. Lysozyme was positive only in pleomorphic type, all these cases have also activity of ACT. Investigated enzymes are useful in diagnosis with correlation to others markers used in diagnostic procedure of soft tissue tumours. PMID:2561861

  19. Fibrous dysplasia of maxillary sinus

    OpenAIRE

    Tinoco, Paulo; Pereira, José Carlos Oliveira; Lourenço Filho, Rodolfo Caldas; Silva, Fabrício Boechat do Carmo; Ruela, Karol Pereira

    2009-01-01

    Introduction: The Fibrous Dysplasia is a benign bone disease, of slow growth and unknown etiology. The involvement of the craniofacial skeleton is not uncommon and, generally, produces facial asymmetries. Case Report: In this article we report the case of a patient with fibrous dysplasia occupying the entire left maxillary sinus with orbitary extension confirmed in the anatomopathological exam. Final Comments: The surgical treatment remains as the main therapeutic approach and the postoperati...

  20. A rare mesenchymal neoplasm at unusual location: Solitary fibrous tumor of vulva

    OpenAIRE

    Nag, G.; Rao, S. R.

    2015-01-01

    •We report a rare case of solitary fibrous tumor of vulva.•The lesion is usually benign.•Needs workup for malignant features and other close differentials.•Early aggressive resection ensuring clear margins is recommended.•Tendency for recurrence warrants long term follow-up.

  1. Solitary fibrous tumor in retroperitoneum

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jeong Sik; Kim, Ki Whang; Kim, Eun Kyung; Kang, Byung Chul; Jeong, Hyeon Joo [Yonsei Univ. College of Medicine, Seoul (Korea, Republic of)

    1996-12-01

    The solitary fibrous tumor, of rare mesodermal origins, primarily affects the pleura and occasionally occurs in the peritoneum and at nonserosal sites. Although this is a pathologically well established entity, it is frequently confused radiologically and pathologically with other tumors of mesenchymal origin. We report one case of a solitary fibrous tumor in the retroperitoneum. The 15X10X7 cm mass, located in the left perirenal space just above the left kidney, had relatively homogeneous consistency and was well-delineated from surrounding organs in CT and MR images. It showed intense, gradual, centripetal enhancement during dynamic scans, and partially unenhanced areas which matched the high signal intensity portions in T2 weighted MR images, pathologically correlated to myxoid degeneration. Although not specific, when a large, well-delineated mass of strong contrast enhancement with lack of massive necrosis is encountered, solitary fibrous tumor must be included in the differential diagnosis of a retroperitoneal soft tissue mass.

  2. Quantification of the magnetization-transfer contrast effect: can it yield additional information in differentiation of musculoskeletal lesions particularly in separation of benign from malignant lesions; Quantifizierung des Magnetization Transfer Contrast (MTC) Effektes durch Berechnung von MT-Quotienten: Ergeben sich Zusatzinformationen fuer die Differenzierung benigner und maligner Erkrankungen des Bewegungsapparates?

    Energy Technology Data Exchange (ETDEWEB)

    Vahlensieck, M.; Traeber, F.; Schild, H. [Radiologische Universitaetsklinik Bonn (Germany); Gieseke, J. [Philips Medizinsysteme (Germany)

    1999-12-01

    Purpose: To investigate the potential information of the amount of magnetization-transfer effect in musculoskeletal lesions and to compare MT ratios from benign and malignant musculoskeletal lesions. Material and Method: 49 patients with malignant tumors (3 osteosarcoma, 3 malignant fibrous histiocytoma, 4 chondrosarcoma, 2 Ewing sarcomas) and benign lesions (8 chondroma, 2 fibrous dysplasia, 3 osteoid-osteoma, 6 ganglion cyst, 3 cyst, 3 osteomyelitis, 4 tendinitis, 3 rotator cuff tear, 5 scar tissue) were scanned using routine MRI protocols including T{sub 1}- and T{sub 2}-weighted spin echo as well as T{sub 2}*-weighted gradient echo (FFE) sequences at 1.5 Tesla (ACS II, Philips Medical). Additionally MTC images were generated by combining the FFE sequence and the off-resonance MT technique (-1500 Hz off-resonance frequency, 1770 flip angle and 50 ms pulse duration). MT ratios were calculated as SI{sub o}-SI{sub m}/SI{sub o}. Results: The MT ratio of benign lesions was 26{+-}15%, that of malignant lesions was 22{+-}6%. The difference was statistically not significant. As expected muscle showed a high MT ratio of 50{+-}8%. Scar tissue demonstrated an MT ratio of 39{+-}16% which was significantly higher than the tumor MT ratios. Conclusion: MTC (MT ratios) failed to show significant differences between benign and malignant lesions as was expected due to basic differences in cellularity, rate of mitosis and chromatin content. MTC might however gain more importance in separating scar tissue from recurrent tumor in the future. (orig.) [German] Zielsetzung: Durch die Quantifizierung des Magnetization Transfer Contrastes sollte untersucht werden, ob sich Zusatzinformationen in der Magnetresonanztomographie des Stuetz- und Bewegungsapparates ergeben. Insbesondere sollte ermittelt werden, ob gut- und boesartige Laesionen unterschiedliche MT-Quotienten aufweisen. Material und Methode: 49 Patienten mit boesartigen Tumoren (3 Osteosarkom, 4 Chondrosarkom, 3 Malignes Fibroeses Histiozytom, 2 Ewing-Sarkom) and gutartigen Erkrankungen (8 Chondrom, 2 Fibroese Dysplasie, 3 Osteoid-Osteom, 6 Ganglion, 3 Zysten, 3 Osteomyelitis, 4 Tendinitis, 3 Rotatorenmanschettenruptur, 5 Narbengewebe) wurden mit herkoemmlicher MRT sowie resonanz-frequenzferner MTC-Methode (-1500 Hz Resonanzverschiebung, 50 ms Pulslaenge, 1770 MT-Pulswinkel) bei 1,5 Tesla (ACS II, Philips Medizinsysteme) untersucht. Der MTC-Effekt wurde durch Berechnung des MT-Quotienten (MT-ratio) quantifiziert. Ergebnisse: Der MT-Quotient gutartiger Laesionen lag im Mittel gering ueber dem maligner Laesionen (26{+-}15% versus 22{+-}6%). Der Unterschied war statistisch nicht signifikant. Narbengewebe wies einen signifikant hoeheren MT-Quotienten (39{+-}16%) als Tumoren auf. Schlussfolgerung: Die Berechnung des MT-Quotienten ist nicht geeignet, um gutartige von boesartigen Erkrankungen des Stuetz- und Bewegungsapparates zu unterscheiden. Zur Differenzierung von Narbengewebe gegenueber Tumorrezidiv koennte MTC einen Stellenwert erlangen. (orig.)

  3. Fibrous dysplasia-recent concepts.

    Science.gov (United States)

    Anitha, N; Sankari, S Leena; Malathi, L; Karthick, R

    2015-04-01

    Fibrous dysplasia (FD) is a benign intramedullary fibro-osseous lesion. FD is a bone developmental anomaly characterized by replacement of normal bone and marrow bone by fibrous tissue. It involves any of the bones as single lesion (monostotic) or in multiple bone lesions (polyostotic) or all of the skeletal system (panostotic). Long bones are most commonly involved, which mostly identified incidentally and clinically appears asymptomatic. Clinical, radiographical and histopathological findings will help in confirming the lesion. There are many treatment option available, but still management of FD remains challenging. PMID:26015701

  4. Fibrous dysplasia of maxillary sinus

    Directory of Open Access Journals (Sweden)

    Tinoco, Paulo

    2009-06-01

    Full Text Available Introduction: The Fibrous Dysplasia is a benign bone disease, of slow growth and unknown etiology. The involvement of the craniofacial skeleton is not uncommon and, generally, produces facial asymmetries. Case Report: In this article we report the case of a patient with fibrous dysplasia occupying the entire left maxillary sinus with orbitary extension confirmed in the anatomopathological exam. Final Comments: The surgical treatment remains as the main therapeutic approach and the postoperative follow-up is necessary due to this condition recurrent nature.

  5. Fibrous metaphyseal defect (fibrous cortical defect, non-ossifying fibroma)

    International Nuclear Information System (INIS)

    Fibrous cortical defect and nonossifying fibromas can be classified together as fibrous metaphyseal defects (FMD) since they have the same pahtological substrate, with a tendency to the same localisation around the knee, and occuring at the same age. They have a tendency to spontaneous healing, are clinically silent and are usually discovered accidentally during radiological examination. A radiological survey fo 5.674 metaphyseal regions in the upper and lower extremities of 2.065 unselected patients aged one to 20 years revealed an incidence of 1.8%; exlcusive examination of the distal femur showed an incidence of 2.7%. 96% of all lesions were in the lower extremities and only 4% in the upper. The marked discrepancy in the incidence rate between American and German publications is discussed. (orig.)

  6. Fibrous Pseudotumor of the Penis – An Unusual Finding During Repair of Fractured Penis

    Directory of Open Access Journals (Sweden)

    Sunny Nalavenkata

    2014-01-01

    Full Text Available Fibrous pseudotumors of the testis and penis are a rare phenomenon, forming a spectrum of heterogeneous lesions. To the best of our knowledge, there has been only 1 previous report arising from the penis. We present a case of fibrous pseudotumor of the penis, incidentally found during the surgical repair of a fractured penis. These benign lesions have been described in the literature and are most commonly referred to as pseudotumors. They should be distinguished from potentially malignant lesions, including fibrosarcomas, squamous cell carcinoma, and polypoid urothelial carcinoma. Being aware of this pathology is important to prevent unnecessary radical surgery.

  7. Creep of fibrous composite materials

    DEFF Research Database (Denmark)

    Lilholt, Hans

    1985-01-01

    Models are presented for the creep behaviour of fibrous composite materials with aligned fibres. The models comprise both cases where the fibres remain rigid in a creeping matrix and cases where the fibres are creeping in a creeping matrix. The treatment allows for several contributions to the creep strength of composites. The advantage of combined analyses of several data sets is emphasized and illustrated for some experimental data. The analyses show that it is possible to derive creep equatio...

  8. Denosumab Treatment for Fibrous Dysplasia

    OpenAIRE

    Boyce, AM; Chong, WH; Yao, J (Jing); Gafni, RI; Kelly, MH; Chamberlain, CE; Bassim, C; Cherman, N; Ellsworth, M; Kasa-Vubu, JZ; Farley, FA; Molinolo, AA; Bhattacharyya, N; Collins, MT

    2012-01-01

    Fibrous dysplasia (FD) is a skeletal disease caused by somatic activating mutations of the cAMP-regulating protein, Gs?. These mutations lead to replacement of normal bone by proliferative osteogenic precursors, resulting in deformity, fracture, and pain. Medical treatment has been ineffective in altering the disease course. RANK ligand (RANKL) is a cell surface protein involved in many cellular processes, including osteoclastogenesis, and is reported to be overexpressed in FD-like bone cells...

  9. Cutaneous Metastatic Undifferentiated Pleomorphic Sarcoma from a Mediastinal Sarcoma

    OpenAIRE

    Jeong, Do Seon; Park, Dong Hwa; Kim, Chi Yeon

    2015-01-01

    Undifferentiated pleomorphic sarcoma, known as malignant fibrous histiocytoma, is a malignant neoplasm that arises in both soft tissue and bones. In 2002, the World Health Organization declassified malignant fibrous histocytoma as a formal diagnostic entity and renamed it 'undifferentiated pleomorphic sarcoma not otherwise specified.' It most commonly occurs in the lower extremities and rarely metastasizes cutaneously. We report a case of cutaneous metastatic undifferentiated pleomorphic sarc...

  10. [Generalized eruptive histiocytoma. Apropos of a case. Review of the literature].

    Science.gov (United States)

    Bobin, P; Carsuzaa, F; Seurat, P; Lucas, D

    1983-01-01

    About one case of generalized eruptive histiocytoma (G.E.H.) (the second French case) and about thirteen others cases mentioned in literature, the authors remind the clinical, histological, immuno-histochemical and evolutive aspects of this misunderstanding disease, described by Winkelmann in 1963. After having classed it, in the group of nodular, non X, non lipidique, benign histiocytosis, they expose the imprecision of this nosological limits of the G.E.H., in comparison to the bordering diseases. At last, they insist upon the fact that the few number of cases published up to this time, the lack of stand back and the casual transformation into a multicentric reticulo-histiocytosis must induce to watchfulness by requiring for each patient affected by G. E. H. and for a long time, a regular, clinical, radiological and hematological supervision. PMID:6666925

  11. Dedifferentiated chondrosarcoma arising in fibrous dysplasia: A case report and review of the current literature

    Directory of Open Access Journals (Sweden)

    Nicole MD Riddle

    2009-06-01

    Full Text Available Nicole MD Riddle1, Hideko Yamauchi2, Jamie T Caracciolo4, David Johnson2, G Douglas Letson2, Ardeshir Hakam1,3, Prudence V Smith1,2,3, Marilyn M Bui1,2,31Department of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA; 2Department of Sarcoma, 3Department of Anatomic Pathology, 4Department of Radiology, Moffitt Cancer Center, Tampa, FL, USABackground: Fibrous dysplasia is an uncommon bone disease that has rare but clear potential for malignant transformation. The frequency is increased in polyostotic forms, McCune–Albright syndrome, Mazabraud’s syndrome, and previously irradiated sites. Rapidly progressing pain unrelated to trauma is the most concerning symptom. The early radiological features of sarcomatous transformation are moth-eaten or cystic areas of osteolysis, cortical destruction, and gradual formation of a soft tissue mass. The prognosis is unfavorable as most of the cases are in an advanced stage at the time of diagnosis.Methods: This case was diagnosed at a large cancer center in Florida. Pertinent clinical findings were obtained from chart review and inter-departmental consultation.Results: Histopathological examination revealed dysplastic lamellar bone with no osteoblastic rimming and “Chinese letter” shapes, areas composed of lobulated hyaline cartilage with mild to severe nuclear atypia, and areas of poorly differentiated cells with a spindled appearance, consistent with chondrosarcoma arising within fibrous dysplasia.Conclusions: Sarcomatous transformation of fibrous dysplasia is an uncommon occurrence, yet has significant importance for those with the disease. There may be difficulty with diagnosis given the symptoms and radiologic findings of benign fibrous dysplasia. We report a case of chondrosarcoma rising in fibrous dysplasia and review the current literature. This case is of interest due to the fact that the diagnosis of monostotic fibrous dysplasia was first made at the age of 59 and malignant transformation occurred within a decade with no history of trauma or radiation. This is an excellent example of how a change in symptoms without a history of trauma should be alarming to the clinician and warrants a thorough work-up for malignancy. To the best of our knowledge, this represents the second case of dedifferentiated chondrosarcoma within the English literature.Keywords: dedifferentiated chondrosarcoma, fibrous dysplasia, malignant transformation, McCune–Albright syndrome, Mazabraud’s syndrome

  12. A case of triple cancer

    International Nuclear Information System (INIS)

    A 31-year-old woman with breast cancer and sigmoid cancer who developed postradiation sarcoma on the chest was reported. There malignant tumors occurred at different times. Pathological examination revealed that breast cancer was classified as infiltrating ductal carcinoma, sigmoid cancer as adenocarcinoma papillotubulae, postradiation sarcoma as malignant fibrous histiocytoma. (Namekawa, K.)

  13. Nutritional fibrous osteodystrophy in goats

    Directory of Open Access Journals (Sweden)

    Paulo M Bandarra

    2011-10-01

    Full Text Available Seven out of 25 goats from a southern Brazilian flock developed nutritional fibrous osteodystrophy. Affected animals were younger than 1 year of age and were confined in stalls and fed a concentrate ration containing 1:6 calcium:phosphorus ratio. The remaining flock (35 goats was managed at pasture and showed no disease. Clinical signs were characterized by mandibular and maxillary enlargements, varying degrees of mouth opening and protruding tongue, dyspnea, apart of abnormalities of prehension and mastication. Affected animals had increased seric levels of phosphorus and parathormone, as well as higher alkaline phosphatase activity. Postmortem examination on three succumbed goats revealed bilateral enlargement of the maxilla and mandibula, and loose teeth, apart of multiple incomplete rib fractures in one of them. Severe diffuse proliferation of loose connective tissue surrounded the osteoid trabeculae, many of which were partially or completely non-mineralized. Mineralized osteoid trabeculae showed osteoclasts in the Howship's lacunae.

  14. Haemangiopericytoma/solitary fibrous tumour of the greater omentum

    Scientific Electronic Library Online (English)

    J H R, Becker; M Z, Koto; O Y, Matsevych; N M, Bida.

    2014-11-01

    Full Text Available We report a rare case of haemangiopericytoma/solitary fibrous tumour of the greater omentum in a 41-year-old woman. It presented as a large mobile abdominal mass measuring 30 ? 24 ? 8 cm. A computed tomography scan confirmed the presence of a large vascular tumour, and biochemical tumour markers wer [...] e non-contributory. The tumour was removed through a conventional laparotomy incision with the aid of a Ligasure dissector. There were no macroscopic metastases, and histologically it was benign. The size of >5 cm, however, suggests that it may have been malignant. In the absence of visible metastases and in view of the favourable histological features, it was decided to follow up the patient very closely and give further treatment if necessary.

  15. Malignant meningioma

    International Nuclear Information System (INIS)

    The intracranial meningiomas are tumors in general of benign type of a slow growth originating in the arachnoid cells layer, especially in arachnoid granulations. The anaplastic or malignant meningiomas accounted for only the 1-3%. Sometimes they simulate malignant neuroepithelial lesions due to its fast growth and the frequent invasion of surrounding cerebral tissue with very frequent relapses and many times they required adjuvant therapy. The topographic images of this type of tumor are hyper-denses with a good contrast capture, regular and well defined with not much or not associated edema, quite the contrary that observed in present case where images seems to correspond with those of a malignant glioma (multiforme glioblastoma). (author)

  16. Malignant Catatonia

    Directory of Open Access Journals (Sweden)

    Ayca Ozkul

    2010-12-01

    Full Text Available Catatonia is a syndrome characterized by mutism, immobility, negativism, stereotypy, mannerisms, echophenomena, perseveration and passive obedience. The underlying causes can be psychiatric or may be associated with general medical status or neurological diseases. Additionally catatonia has two subtypes as malignant and nonmalignant catatonia. Main symptoms of malignant catatonia are hyperthermia and autonomic symptoms such as tachycardia, tachypnea and hyperhidrosis. It is important to make the diagnosis as early as possible for an appropriate medical treatment. Clinicians should be aware of the fatal outcome of the disease.

  17. Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma

    Indian Academy of Sciences (India)

    Kolla V, P Rasad; Aftab Taiyab; D Jyothi; Usha K Srinivas; Amere S Sreedhar

    2007-04-01

    Heat shock response is associated with the synthesis of heat shock proteins (Hsps) which is strictly regulated by different members of heat shock transcription factors (HSFs). We previously reported that a rat histiocytoma, BC-8 failed to synthesize Hsps when subjected to typical heat shock conditions (42°C, 60 min). The lack of Hsp synthesis in these cells was due to a failure in HSF1 DNA binding activity. In the present study we report that BC-8 tumor cells when subjected to heat shock at higher temperature (43°C, 60 min) or incubation for longer time at 42°C, exhibited necrosis characteristics; however, under mild heat shock (42°C, 30 min) conditions cells showed activation of autophagy. Mild heat shock treatment induced proteolysis of HSF1, and under similar conditions we observed an increase in HSF2 expression followed by its enhanced DNA binding activity. Inhibiting HSF1 proteolysis by reversible proteasome inhibition failed to inhibit heat shock induced autophagy. Compromising HSF2 expression but not HSF1 resulted in the inhibition of autophagy, suggesting HSF2 dependent activation of autophagy. We are reporting for the first time that HSF2 is heat inducible and functions in heat shock induced autophagic cell death in BC-8 tumor cells.

  18. Filtration efficiency of an electrostatic fibrous filter

    DEFF Research Database (Denmark)

    Ardkapan, Siamak Rahimi; Johnson, Matthew Stanley; Yazdi, Sadegh; Afshari, Alireza; Bergsøe, Niels Christian

    2014-01-01

    The objective of the present study is to investigate the relationship between ultrafine particle concentrations and removal efficiencies for an electrostatic fibrous filter in a laboratory environment. Electrostatic fibrous filters capture particles efficiently, with a low pressure drop. Therefore they have applications in building ventilation systems. The relationship between particle removal efficiency and particle concentration has not been widely investigated in ventilation systems and indoo...

  19. Craniofacial polyostotic fibrous dysplasia: A rare case

    OpenAIRE

    Owlia, Fatemeh; Karbassi, Mohammad-Hassan Akhavan

    2014-01-01

    Craniofacial fibrous dysplasia (FD) is one of three types of FD which can affect the craniofacial complex. It is the proliferation of cellular fibrous connective tissue intermixed with irregular bony trabecules. It is a developmental tumor-like condition that is characterized by replacement of normal bone. The purpose of this report is to present a rare case of craniofacial polyostotic FD that led to vision loss in the same affected side.

  20. Development of bioactive photocrosslinkable fibrous hydrogels.

    Science.gov (United States)

    Stephens-Altus, J S; Sundelacruz, P; Rowland, M L; West, J L

    2011-08-01

    Three-dimensional (3D) fibrous hydrogels were fabricated by blending two photoactive polymers, poly(ethylene glycol) diacrylate (PEGDA) and poly(vinyl alcohol) (PVA), and the resulting solution was electrospun. PEGDA is a commonly used hydrogel material for tissue engineering applications since its interaction with cells can be tuned by crosslinking in a variety of bioactive molecules including peptides and proteins. The PVA in these materials aids in fiber formation and stabilizes the fibrous network when hydrated. The average dry fiber diameter in the hydrogels was 1.02 ?m and upon swelling, the fiber diameter increased approximately six-fold. Fibers were stable under cell culture conditions for up to 5 days. The adhesive ligand, RGDS, was readily incorporated into the fibrous network via the conjugation of RGDS to PEG-monoacrylate which was then crosslinked with the fibers. The bioactivity of the fibrous hydrogels was compared with peptide-modified PEGDA-based hydrogels. The two hydrogel materials had similar cell adhesion and viability. Cell morphology on the fibrous hydrogels was dendritic showing a more in vivo like representation, as compared to spread cell morphology on the PEGDA gels. The ability to generate 3D fibrous architectures in hydrogel systems opens up new areas of investigation in cell-material interactions and tissue formation. PMID:21548066

  1. CT Imaging of Craniofacial Fibrous Dysplasia

    Science.gov (United States)

    Unal Erzurumlu, Zerrin; Celenk, Peruze; Bulut, Emel; Bar?s, Yakup Sancar

    2015-01-01

    Fibrous dysplasia is a benign fibroosseous bone dysplasia that can involve single (monostotic) or multiple (polyostotic) bones. Monostotic form is more frequent in the jaws. It is termed as craniofacial fibrous dysplasia, when it involves, though rarely, adjacent craniofacial bones. A 16-year-old girl consulted for a painless swelling in the right posterior mandible for two years. Panoramic radiography revealed ground-glass ill-defined lesions in the three different regions of the maxilla and mandible. Axial CT scan (bone window) showed multiple lesions involving skull base and facial bones. Despite lesions in the skull base, the patient had no abnormal neurological findings. The lesion was diagnosed as fibrous dysplasia based on radiological and histopathological examination. In this paper, CT findings and differential diagnosis of CFD are discussed. CT is a useful imaging technique for CFD cases. PMID:26339510

  2. Acoustic behavior of fibrous bulk materials

    Science.gov (United States)

    Hersh, A. S.; Walker, B.

    1980-01-01

    A semiempirical model of the acoustic behavior of fibrously constructed bulk materials of Hersh and Walker (1979) is generalized to take into account the filtration or removal of particles by fibrous mats and heat conduction between the material fibers and the surrounding fluid. Equations governing the propagation and attenuation of sound waves in a fibrous material are derived on the basis of a solution of the Navier Stokes equation for momentum conservation and a one-dimensional model of heat transfer between the sound field and the fibers. A comparison of the two propagation constants and material impedance specified by the model and experimental measurements for Kevlar 29 indicates the accuracy of the model over a wide range of sound frequencies, material porosities and specimen thickness. It is also found that heat transfer effects are relatively unimportant, while the attenuation constants and material characteristic impedance are a function of fiber orientation relative to sound field propagation direction.

  3. FIBROUS DYSPLASIA IN THE MAXILLO-MANDIBULAR REGION – case report

    OpenAIRE

    Radka Cholakova; P. Kanasirska; N. Kanasirski; Ivan Chenchev; Atanaska Dinkova

    2010-01-01

    Craniofacial fibrous dysplasia is 1 of 3 types of fibrous dysplasia that can affect the bones of the craniofacial complex, including the mandible and maxilla.Fibrous displasia is a skeletal developmental disorder of the bone-forming mesenchyme that manifests as a defect in osteoblastic differentiation and maturation. It is a lesion of unknown etiology, uncertain pathogenesis, and diverse histopathology. Fibrous dysplasia represents about 2, 5% of all bone tumors and over 7% of all benign tumo...

  4. Dedifferentiated chondrosarcoma arising in fibrous dysplasia: A case report and review of the current literature

    OpenAIRE

    Nicole MD Riddle; Hideko Yamauchi; Jamie T Caracciolo; David Johnson; et al.

    2009-01-01

    Nicole MD Riddle1, Hideko Yamauchi2, Jamie T Caracciolo4, David Johnson2, G Douglas Letson2, Ardeshir Hakam1,3, Prudence V Smith1,2,3, Marilyn M Bui1,2,31Department of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA; 2Department of Sarcoma, 3Department of Anatomic Pathology, 4Department of Radiology, Moffitt Cancer Center, Tampa, FL, USABackground: Fibrous dysplasia is an uncommon bone disease that has rare but clear potential for malignant transformation. The...

  5. Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia

    International Nuclear Information System (INIS)

    We describe two cases of elderly women who presented hypoglycemic episodes with suppressed levels of insulin and insulin-like growth factor I. They were found to have huge malignant solitary fibrous tumor of the pleura. The tumors had rich vascularization on enhanced CT scans and showed characteristic low signal intensity on T2-weighted MR images. This paraneoplastic hypoglycemia is caused by an incompletely processed precursor of insulin-like growth factor II secreted from the tumor. Hypoglycemia and insulin suppression were resolved after removal of the tumors. (orig.)

  6. Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J.H. [Dept. of Diagnostic Radiology, Chungnam National University Hospital, Taejon (Korea); Kim, J.O.; Kim, S.Y. [Dept. of Internal Medicine, Chungnam National University Hospital, Taejon (Korea); Na, M.H.; Lim, S.P. [Dept. of Thoracic Surgery, Chungnam National University Hospital, Taejon (Korea); Kim, J.M. [Dept. of Pathology, Chungnam National University Hospital, Taejon (Korea)

    2001-05-01

    We describe two cases of elderly women who presented hypoglycemic episodes with suppressed levels of insulin and insulin-like growth factor I. They were found to have huge malignant solitary fibrous tumor of the pleura. The tumors had rich vascularization on enhanced CT scans and showed characteristic low signal intensity on T2-weighted MR images. This paraneoplastic hypoglycemia is caused by an incompletely processed precursor of insulin-like growth factor II secreted from the tumor. Hypoglycemia and insulin suppression were resolved after removal of the tumors. (orig.)

  7. Steam Reformer With Fibrous Catalytic Combustor

    Science.gov (United States)

    Voecks, Gerald E.

    1987-01-01

    Proposed steam-reforming reactor derives heat from internal combustion on fibrous catalyst. Supplies of fuel and air to combustor controlled to meet demand for heat for steam-reforming reaction. Enables use of less expensive reactor-tube material by limiting temperature to value safe for material yet not so low as to reduce reactor efficiency.

  8. Temporosphenoidal Fibrous Dysplasia: A Case Report

    Directory of Open Access Journals (Sweden)

    Mustafa ERDAL

    2006-12-01

    Full Text Available Fibrous dysplasia (FD is a localized disorder of bone that may lead to bony distortional expansions. We report a case of FD of the temporosphenoidal bone. In this case, we took out subtotally the part of the temporal bone extending to the skull base with speed-drilling.

  9. Temporosphenoidal Fibrous Dysplasia: A Case Report

    OpenAIRE

    Mustafa ERDAL; Mustafa Aziz HAT?BO?LU; Murat ÇO?AR; Mahmut ARSLAN; Celal ?PL?KÇ?O?LU

    2006-01-01

    Fibrous dysplasia (FD) is a localized disorder of bone that may lead to bony distortional expansions. We report a case of FD of the temporosphenoidal bone. In this case, we took out subtotally the part of the temporal bone extending to the skull base with speed-drilling.

  10. Unilateral Fibrous ankylosis of the Temporomandibular Joint

    Directory of Open Access Journals (Sweden)

    Kamala R

    2012-04-01

    Full Text Available Ankylosis of the Temporomandibular joint (TMJ is a chronic mandibular hypomobility and is one of the commonest TMJ disorders encountered in the patients.The present case is about the history of fourteen years old fibrous ankylosis of the condyle of the TMJ with its clinical and the radiological features and the treatment modalities.

  11. Damage mechanisms of random fibrous networks

    Science.gov (United States)

    Sozumert, E.; Farukh, F.; Demirci, E.; Acar, M.; Pourdeyhimi, B.; Silberschmidt, V. V.

    2015-07-01

    Fibrous networks are ubiquitous: they can be found in various engineering applications as well as in biological tissues. Due to complexity of their random microstructure, anisotropic properties and large deformation, their modelling is challenging. Though, there are numerous studies in literature focusing either on numerical simulations of fibrous networks or explaining their damage mechanisms at micro or meso-scale, the respective models usually do not include actual random microstructure and failure mechanisms. The microstructure of fibrous networks, together with highly non-linear mechanical behaviourof their fibres, is a key to initiation of damage, its spatial localization and ultimate failure [1]. Numerical models available in literature are not capable of elucidating actual microstructure of the material and, hence, its influence on damage processes in fibrous networks. To emulate a real-life microstructure in a developed finite-element model, an orientation distribution function for fibresobtained from X-ray micro computed-tomography images was considered to provide actual alignment of fibres. To validate the suggested model, notched and unnotched rectangular specimens were experimentally tested. A good correlation between the experimental data and simulation results was observed. This study revealed a significant effect of a notch on damage evolution.

  12. Aneurysmal bone cyst associated with fibrous dysplasia.

    Science.gov (United States)

    Yuen, Vernon Ho; Jordan, David R; Jabi, Maha; Agbi, Charles

    2002-11-01

    We report the clinicopathologic features of a 22-year-old patient with aneurysmal bone cyst and fibrous dysplasia of the orbit. The patient was evaluated clinically with computed tomography of the orbit before surgery. An orbital biopsy specimen was examined histologically with conventional light microscopy. The lesion was treated with combined neurosurgical and orbital intervention. Clinical evaluation revealed axial and inferior displacement of the globe. Computed tomography revealed a cystic mass in the superotemporal left orbit with adjacent bone erosion. "Ground-glass" thickening of the adjacent frontal bone and sphenoid bone was observed. Microscopic examination showed fibrous stroma with giant cells and hemosiderin-laden macrophages with adjacent trabeculae of woven bone and osteoblast cells. A fronto-orbital craniotomy was performed, the cystic cavity was excised, and the hyperostotic bone was debulked. After treatment, the globe position and patient appearance have improved. There has been no sign of recurrence of the aneurysmal bone cyst. Aneurysmal bone cyst should be considered in patients with fibrous dysplasia that has a cystic component, or in patients with fibrous dysplasia who present with sudden expansion of their lesion. PMID:12439066

  13. Fibrous mineral sorbents for concentration of radionuclides

    International Nuclear Information System (INIS)

    The sorption properties of fibrous mineral sorbents prepared from modified clinoptilolite and an acidic cellulose ester containing hexacyanoferrates are studied. The sorbents can be used to purify liquid radioactive wastes with a total specific activity of (4.9-7)·10-6 Ci/liter

  14. Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Haris S Vasiliadis

    2013-01-01

    Full Text Available We report a case of a 32 year-old male, admitted for a lytic lesion of the distal femur. One month after the first X-ray, clinical and imaging deterioration was evident. Open biopsy revealed fibrous dysplasia. Three months later, the lytic lesion had spread to the whole distal third of the femur reaching the articular cartilage. The malignant clinical and imaging features necessitated excision of the lesion and reconstruction with a custom-made total knee arthroplasty. Intra-operatively, no obvious soft tissue infiltration was evident. Nevertheless, an excision of the distal 15.5 cm of the femur including 3.0 cm of the surrounding muscles was finally performed. The histological examination of the excised specimen revealed central low-grade osteosarcoma. Based on the morphological features of the excised tumor, allied to the clinical findings, the diagnosis of low-grade central osteosarcoma was finally made although characters of a fibrous dysplasia were apparent. Central low-grade osteosarcoma is a rare, well-differentiated sub-type of osteosarcoma, with clinical, imaging, and histological features similar to benign tumours. Thus, initial misdiagnosis is usual with the condition commonly mistaken for fibrous dysplasia. Central low-grade osteosarcoma is usually treated with surgery alone, with rare cases of distal metastases. However, regional recurrence is quite frequent after close margin excision.

  15. Solitary fibrous tumor of the mammary gland: a potential pitfall in breast pathology.

    Science.gov (United States)

    Falconieri, Giovanni; Lamovec, Janez; Mirra, Maurizio; Pizzolitto, Stefano

    2004-06-01

    We report three cases of solitary fibrous tumor of the breast. The patients were adult to elderly women and complained of a slowly but relentless growing lump. The tumors were fairly circumscribed and cured by means of lumpectomy or, in one case, simple mastectomy. Histologically, they featured the customary "patternless pattern" of short spindle cells haphazardly arranged in fascicles within a collagenized or myxoid ground substance. In two cases, a prominent hemangiopericytic arrangement of tumor cells around a rich vascular framework could be noticed. Cellular areas were often present and showed nuclear overlapping, clumping of chromatin, and a brisk mitotic activity. No atypical mitosis was recognized. Tumor cells were immunoreactive for CD34, bcl2, and vimentin only. On follow-up there was no evidence of either local recurrence or distant metastases. Solitary fibrous tumors of the breast may represent a significant diagnostic problem because of the close mimicry to numerous benign and malignant mammary lesions composed of spindle cells; diagnostic clues may be further obscured in cellular and actively proliferating tumors. A brief overview of mammary solitary fibrous tumor taxonomy along with the principal differential diagnoses within the breast is presented. PMID:15185257

  16. Malignant lymphoma

    International Nuclear Information System (INIS)

    This paper describes the background and treatment, especially focusing on radiotherapy (RT), of stage I-II malignant lymphoma (ML) occurring in head and neck. For diffuse large B-cell lymphoma, the most frequently occurring ML in Japan (about 40% of all MLs), the current standard protocol involves 3 cycles of chemotherapy (CT) like rituximab to cyclophosphamide/doxorubicin/vincristine/predonisolone (CHOP) regimen followed by RT. Authors use the dose around 30 Gy/15 fr for CR patients after CHOP and 40-50 Gy/20-25 fr for PR ones. Recurrence scarcely occurs in the RT target region. However, significance of RT is still somehow controversial in this ML and addition of CHOP is currently noted. Mucosa-associated lymphoid tissue lymphoma (8.45% of Japanese ML) occurs mainly in glands and orbit and may be related with Chlamydia infection. RT is usually conducted to the whole organ with lesion as the clinical target with fractionated 30 Gy. Nasal NK/T cell lymphoma (2.6%), possibly associated with Epstein-Barr (EB) virus, is usually resistant to CHOP. Recommended is CT after RT with the dose of 50-54 Gy and depending on the target site, advanced RT like intensity-modified one is desirable. Hodgkin lymphoma (about 5%) occurs in lymph node and is derived from B-lymphocyte. Irradiation field involves the region of the disease node or that additionally including its neighbors and doses of about 20 Gy and 30 Gy are given in child and adult patients, respectively. For follicular and other tissue type lymphomas, noted are novel therapies like rituximab-combined CT, immuno-RT with 90Y-ibritumomab and 131I-tositumomab. Recently, positron emission tomography (PET) is essential for treatment assessment of the clinical response of ML in the guideline. (R.T.)

  17. Fibrous Hamartoma of Infancy, Report of Two Cases

    Directory of Open Access Journals (Sweden)

    Ahmad Bazrafshan

    2008-05-01

    Full Text Available Objective: Fibrous hamartoma of infancy (FHI is a rare, benign soft tissue tumor that typically occurs within the first two years of life. It has a specific histologic appearance comprising of three different mesenchymal tissues with variable proportions in an organoid fashion. The clinical course is typically benign with excellent prognosis. We report two cases of this rare lesion and review its cilinicopathologic characteristics. Case(s Presentation: The first case was a 15-month-old girl who had a subcutaneous mass in the right axillary region and the other one was an 18-month-old boy with a mass on the medial surface of his right ankle. The masses were successfully excised. After 6 and 30 months follow up no recurrence occurred. Conclusion: Although the clinical and imaging findings of FHI are quite similar to those of malignant soft tissue tumor, histologic characteristics of this tumor will guide to the definite diagnosis that will prevent aggressive and mutilating procedures.

  18. [Solitary Fibrous Tumors of the Nasal and Paranasal Sinuses].

    Science.gov (United States)

    Minami, Kazuhiko; Kuba, Kiyomi; Matsumura, Satoko; Hayashi, Takahiro; Nakahira, Mitsuhiko; Sugasawa, Masashi; Yamaguchi, Hiroshi; Takayanagi, Natsuko

    2015-07-01

    Solitary fibrous tumors (SFT) are uncommon neoplasm that arises in most cases from the pleura. SFT has been rarely observed in the head and neck, but SFT of the paranasal sinuses is especially rare, with 39 previously reported cases to date including those reported in this abstract. Herein we describe three cases of SFT in the paranasal sinuses that were successfully treated endoscopically. Two of the three cases involved patients with no previous history of SFT. The lesion of one of the patients was pathologically diagnosed as SFT preoperatively, but the other was diagnosed as an angiogenic tumor without any biopsies. The tumors were completely resected after arterial embolization by a transnasal endoscopic procedure. The third case involved a 43-year old man, who had undergone medial maxillectomy through a lateral rhinotomy incision to resect SFT four years and seven months before. The tumor relapsed intracranially and, therefore, a craniotomy procedure followed by endoscopic skull base surgery was performed. Radiation therapy was performed postoperatively because the recurrent tumor was pathologically identified as malignant SFT, which had been classified benign at the time of the first resection. All three patients are presently alive with no evidence of disease. PMID:26427128

  19. Nonlinear mechanics of soft fibrous materials

    CERN Document Server

    Ogden, Raymond

    2015-01-01

    The book presents a state-of-the-art overview of the fundamental theories, established models and ongoing research related to the modeling of these materials. Two approaches are conventionally used to develop constitutive relations for highly deformable fibrous materials. According to the phenomenological approach, a strain energy density function can be defined in terms of strain invariants. The other approach is based on kinetic theories, which treats a fibrous material as a randomly oriented inter-tangled network of long molecular chains bridged by permanent and temporary junctions. At the micro-level, these are associated with chemical crosslinks and active entanglements, respectively. The papers include carefully crafted overviews of the fundamental formulation of the three-dimensional theory from several points of view, and address their equivalences and differences. Also included are solutions to boundary-value problems which are amenable to experimental verification. A further aspect is the elasticity...

  20. Protease-degradable electrospun fibrous hydrogels

    Science.gov (United States)

    Wade, Ryan J.; Bassin, Ethan J.; Rodell, Christopher B.; Burdick, Jason A.

    2015-03-01

    Electrospun nanofibres are promising in biomedical applications to replicate features of the natural extracellular matrix (ECM). However, nearly all electrospun scaffolds are either non-degradable or degrade hydrolytically, whereas natural ECM degrades proteolytically, often through matrix metalloproteinases. Here we synthesize reactive macromers that contain protease-cleavable and fluorescent peptides and are able to form both isotropic hydrogels and electrospun fibrous hydrogels through a photoinitiated polymerization. These biomimetic scaffolds are susceptible to protease-mediated cleavage in vitro in a protease dose-dependent manner and in vivo in a subcutaneous mouse model using transdermal fluorescent imaging to monitor degradation. Importantly, materials containing an alternate and non-protease-cleavable peptide sequence are stable in both in vitro and in vivo settings. To illustrate the specificity in degradation, scaffolds with mixed fibre populations support selective fibre degradation based on individual fibre degradability. Overall, this represents a novel biomimetic approach to generate protease-sensitive fibrous scaffolds for biomedical applications.

  1. Aerosol filtration with metallic fibrous filters

    International Nuclear Information System (INIS)

    The filtration efficiency of stainless steel fibrous filters (BEKIPOR porous mats and sintered webs) is determined using submicronic monodisperse polystyrene aerosols. Lasers spectrometers are used for the aerosol measurements. The parameters varied are the fiber diameter, the number of layers, the aerosol diameter and the superficial velocity. Two selected types of filters are tested with polydisperse methylene blue aerosols to determine the effect of bed loading on the filter performance and to test washing techniques for the regeneration of the filter

  2. Composite films of arabinoxylan and fibrous sepiolite

    DEFF Research Database (Denmark)

    Sárossy, Zsuzsa; Blomfeldt, Thomas O.J.; Hedenqvist, Mikael S.; Bender Koch, Christian; Ray, Suprakas Sinha; Plackett, David

    2012-01-01

    Hemicelluloses represent a largely unutilized resource for future bioderived films in packaging and other applications. However, improvement of film properties is needed in order to transfer this potential into reality. In this context, sepiolite, a fibrous clay, was investigated as an additive to enhance the properties of rye flour arabinoxylan. Composite films cast from arabinoxylan solutions and sepiolite suspensions in water were transparent or semitransparent at additive loadings in the 2.5...

  3. Oriented fibrous structures for concrete reinforcement

    OpenAIRE

    Fangueiro, Raúl; Marques, P.; Pereira, Cristiana Gonilho; Araújo, Mário Duarte de

    2010-01-01

    This paper reports on the work that is being undertaken at the University of Minho concerning the development of directionally oriented fibrous structures (DOFS) to be used as a concrete reinforcement material. Several glass fibre wovenlike DOFS were produced varying two parameters: roving linear density (tex) and reinforcement structural density (rovings/cm). Self-compacting concrete slabs were reinforced by DOFS structures and their bending behaviour was evaluated. The results were compared...

  4. Spontaneous fibrous histiocytic neoplasms in rats.

    OpenAIRE

    Greaves, P.; Faccini, J M

    1981-01-01

    A total of 85 spontaneous rat fibrohistiocytic tumours were evaluated histologically and assessed for the presence or absence of metastases. The overall incidence in controls from 2-year carcinogenicity studies was 2.7%. The tumours occurred principally in the subcutaneous and deep soft tissues, and generally appeared after 18 months of age. Four histological types were recognized: histiocytic (17%), pleomorphic (33%), cellular (17%) and very fibrous (33%). Histiocytic tumours were highly mal...

  5. Toxicity and Carcinogenicity Mechanisms of Fibrous Antigorite

    OpenAIRE

    Michael Balazy; Silvana Capella; Annamaria Panico; Elena Belluso; Laura Lombardo; Venera Cardile

    2007-01-01

    We studied the effects of fibrous antigorite on mesothelial MeT-5A and monocyte-macrophage J774 cell lines to further understand cellular mechanisms induced by asbestos fibers leading to lung damage and cancer. Antigorite is a mineral with asbestiform properties, which tends to associate with chrysotile or tremolite, and frequently occurs as the predominant mineral in the veins of several serpentinite rocks found abundantly in the Western Alps. Particles containing antigorite are more abundan...

  6. Toxicity and Carcinogenicity Mechanisms of Fibrous Antigorite

    Directory of Open Access Journals (Sweden)

    Michael Balazy

    2007-03-01

    Full Text Available We studied the effects of fibrous antigorite on mesothelial MeT-5A and monocyte-macrophage J774 cell lines to further understand cellular mechanisms induced by asbestos fibers leading to lung damage and cancer. Antigorite is a mineral with asbestiform properties, which tends to associate with chrysotile or tremolite, and frequently occurs as the predominant mineral in the veins of several serpentinite rocks found abundantly in the Western Alps. Particles containing antigorite are more abundant in the breathing air of this region than those typically found in urban ambient air. Exposure of MeT-5A and J774 cells to fibrous antigorite at concentrations of 5-100 μg/ml for 72 hr induced dose-dependent cytotoxicity. Antigorite also stimulated the ROS production, induced the generation of nitrite and PGE2. MeT-5A cells were more sensitive to antigorite than J774 cells. The results of this study revealed that the fibrous antigorite stimulates cyclooxygenase and formation of hydroxyl and nitric oxide radicals. These changes represent early cellular responses to antigorite fibers, which lead to a host of pathological and neoplastic conditions because free radicals and PGE2 play important roles as mediators of tumor pathogenesis. Understanding the mechanisms of the cellular responses to antigorite and other asbestos particles should be helpful in designing rational prevention and treatment approaches.

  7. Intramedullary Solitary Fibrous Tumor of Cervicothoracic Spinal Cord

    OpenAIRE

    Hwang, Ui Seung; Kim, Sung Bum; Jo, Dae Jean; Kim, Sung Min

    2014-01-01

    Solitary fibrous tumor is rare benign mesenchymal neoplasm. The spinal solitary fibrous tumor is extremely rare. The authors experienced a case of intramedullary solitary fibrous tumor of cervicothoracic spinal cord in a 48-year-old man with right lower extremity sensory disturbance. Spinal MRI showed intradural mass lesion in the level of C7-T1, the margin between the spinal cord and tumor was not clear on MRI. A Left unilateral laminectomy and mass removal was performed. Intra operative fin...

  8. Design of fibrous structures for civil engineering applications

    OpenAIRE

    Marques, Paula Cristina Martins Pina

    2009-01-01

    As a synergy of fibre and fibrous structures technology developments, nowadays it is possible to produce advanced fibrous materials for many non-conventional applications. The use of fibrous materials as reinforcement materials of cementitious matrices is one of its many applications that have gain new developments over the last years. Due to its inherent low tensile strength, concrete requires reinforcement in applications where significant tensile stresses will be realized in...

  9. THE INFLUENCE OF SUPERPLASTICIZERS ON THE PROPERTY IS FIBROUS CONCRETE / ??????? ???????????????????? ?? ???????? ????????????

    Directory of Open Access Journals (Sweden)

    Perfilov Vladimir Aleksandrovich / ???????? ???????? ?????????????

    2015-02-01

    Full Text Available Provided are the results of experimental studies on the determination of the effect of superplasticizer additives on physical and mechanical properties of basalt fibrous concrete / ???????????? ?????????? ????????????????? ???????????? ?? ??????????? ??????? ????????????????????? ??????? ?? ??????-???????????? ???????? ????????????????????

  10. Malignant bone tumors

    International Nuclear Information System (INIS)

    Clinicoroentgenologic semiotics of malignant bone tumors as well as metastatic bone tumors are presented. Diagnosis of malignant and metastatic bone tumors should be always complex, representing a result of cooperation of a physician, roentgenologist, pathoanatomist

  11. Fibrous composites comprising carbon nanotubes and silica

    Science.gov (United States)

    Peng, Huisheng (Shanghai, CN); Zhu, Yuntian Theodore (Cary, NC); Peterson, Dean E. (Los Alamos, NM); Jia, Quanxi (Los Alamos, NM)

    2011-10-11

    Fibrous composite comprising a plurality of carbon nanotubes; and a silica-containing moiety having one of the structures: (SiO).sub.3Si--(CH.sub.2).sub.n--NR.sub.1R.sub.2) or (SiO).sub.3Si--(CH.sub.2).sub.n--NCO; where n is from 1 to 6, and R.sub.1 and R.sub.2 are each independently H, CH.sub.3, or C.sub.2H.sub.5.

  12. Giant solitary fibrous tumour of the pleura

    DEFF Research Database (Denmark)

    Bødtger, Uffe; Pedersen, Jesper Holst; Skov, Birgit Guldhammer; Clementsen, Paul

    2009-01-01

    BACKGROUND: Low forced expiratory volume (FEV(1)) and low performance status usually preclude surgical treatment of lung neoplasms. Earlier case reports have suggested that curative, safe surgery is possible in extrapulmonal intrathoracic neoplasms. METHODS: A case report of an 83-year-old women with progressing dyspnoea secondary to a huge left-side neoplasm. RESULTS: Work-up reveal an FEV(1) of 0.4 L, and a giant solitary fibrous tumor of the pleura. The tumor was surgically removed in toto wi...

  13. Malignant lymphoma in central nervous system (CNS)

    International Nuclear Information System (INIS)

    A 71-year-old male was admitted to Kohka Public Hospital on January 4, 1980, because of frequent vomiting and recent memory loss. Two weeks before admission upper G-I series showed no abnormalities. Physical and neurological examinations revealed no abnormalities except for slightly apathetic appearance and recent memory loss. Mild pleocytosis and marked increase of protein in CSF were observed. CT scan on January 17 showed high density areas in both medial sides of temporal lobes with remarkable contrast enhancement. His memory and, consciousness disturbances gradually aggravated, accompanied by abnormal density spreading around the ventricle walls like ventriculitis. He was transfered to Kyoto University Hospital on March 17, and malignant lymphoma was diagnosed on the basis of CSF cytology. Radiation and chemotherapy alleviated the CNS involvement and he regained normal mental function. On June 16, he developed pneumonia followed by status epilepticus. Autopsy findings revealed no lymphoid cell infiltration, but fibrous tissues in both hippocampal gyri and lymphomatous cells in the liver, which could not be suspected on clinical examinations. Apparent malignant lymphoma cells were not found in lymph nodes. This case indicated peculiar evolution of malignant lymphoma from liver to CNS or vice versa. We could not decide which organ was primary. CT findings of this case was very interesting; they resembled ventriculitis, which simulate tumors such as medulloblastoma or ependymoma spreading under ependymal lining. (author)

  14. Imaging Findings of Fibrous Hamartoma of Infancy

    Energy Technology Data Exchange (ETDEWEB)

    Rho, Byung Hak; Lee, Hee Jung; Kwon, Sun Young [Dongsan Medical Center, Keimyung University College of Medicine, Daegu (Korea, Republic of)

    2009-09-15

    We wanted to evaluate the imaging findings of fibrous hamartoma of infancy (FHI). We retrospectively reviewed the clinical presentation and the sonographic (n = 5) and CT (n = 3) findings of 5 cases of surgically/pathologically confirmed FHI. The sonographic findings were evaluated according to the location, size, internal echogenicity and vascularity. The CT findings were evaluated according to the attenuation of the mass on both the pre- (n = 3) and postcontrast (n = 2) scans. The image findings were correlated with the pathologic findings. The mean age was 14.8 months (range, 7 months - 3 years). The location of lesions was all in the fatty layer of the back (n = 4) and upper arm (n = 1). All the lesions demonstrated-hypertrichosis on the overlying skin. The lesions measured 31.2 mm in the longest diameter (range: 18 mm - 50 mm). The sonographic findings were purely solid, heterogeneously hyperechoic and hypovacular for all the cases. The internal architecture revealed a 'layering' appearance (n = 3). The CT findings demonstrated isoattenuation, as compared to the adjacent muscle on both the pre- and postcontrast CT scans. The pathologic correlation demonstrated a characteristic 'organoid' mixture of fibrous, mucoid and fatty tissues in all cases. The diagnosis of FHI can be suggested by the sonographic findings of a superficially located, heterogeneous solid mass with a 'layering' appearance in the fatty layer of the back or arms of infants with local hypertrochosis on the overlying skin.

  15. Briquetting and coking behavior of fibrous xylite

    Energy Technology Data Exchange (ETDEWEB)

    Naundorf, W.; Wollenberg, R.; Cichos, N.

    1988-01-01

    Studies laboratory briquetting and coking of wood structured cellulose fiber xylite which makes up 6 to 12% of Miocene brown coal in the GDR. The briquets produced, fibrous in appearance, had high compression strength; the coke compression strength was slightly below the 14 to 18 MPa level of regular brown coal coke. The addition of more than 25% sulfite liquor as binder significantly increased coke strength and density as well as lump coke formation. The possibility of employing xylite for fibrous particleboards in the wood industry is further assessed. Bending strength of xylite briquets pressed with addition of glue and hardener was between 9.8 and 13.5 MPa, furthermore, water resistance of briquets is described as high. Experiments also showed that pressing pressure can be reduced to 75 MPa, without significant losses in bending strength. Size reduction of xylite is regarded as important, i.e. a reduction of xylite particle size from 1.1/0 mm to 0.6/0 mm increases bending strength of briquets by an average of 5 MPa. Graphs of measurement results are provided. 9 refs.

  16. Marfan syndrome with multiseptate pneumothorax and mandibular fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Kate A

    2009-01-01

    Full Text Available We describe a rare case of pneumothorax due to Marfan syndrome associated with fibrous dysplasia of the mandible. Marfan syndrome and fibrous dysplasia were possibly due to a common etiological factor. The association between the two and other tumors described in literature related to Marfan syndrome is discussed.

  17. Fibrous microcapsules and methods of assembly and use thereof

    Science.gov (United States)

    Stupp, Samuel; Rozkiewicz, Dorota

    2015-01-27

    The present invention relates to assembly of peptide amphiphiles and biopolymers into fibrous microcapsules, and uses thereof. In particular, the present invention provides devices, compositions, and methods for interfacial self-assembly of peptide amphiphiles and biopolyments into fibrous microcapsules, and uses thereof.

  18. Lignitic fibrous xylite as substrate soil; Braunkohlenfaserxylit als Substratboden

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, H.W.; Naundorf, W.; Strassburger, U. [Freiberg Univ. of Mining and Technology (Germany)

    2005-03-01

    Substrate soils are used in large quantities for cultivating vegetables, flowers, and ornamental plants in greenhouses as well as for growing trees and shrubs. Peat, coconut fibers as weel as high-grade composts, for example from barks and rice husks, are used primarily for the production of substrate soils. During growth, the substrate soils fulfill essential physical functions such as water and nutrient supply, water storage, soil aeration, and rooting capacity. This article presents the results of tests which were to determine if fibrous xylite from Lausitz lignite could also fulfill these soil functions. Neogene Lausitz lignites contain high proportions of high-grade fibrous xylite. The fibrous xylite has an extensive interstratification with the detritic coal matrix. By means of a special comminution/classification technology, the fibrous xylite is separated in pure form from the coal matrix. The almost coal-free fibrous xylite has many positive properties which lead to the assumption that xylite is suitable as substrate soil. Fibrous xylite's ability to function as a soil modifier has already been reported. Thus, fibrous xylite is a high-grade soil modifier if it is mixed with other soil in proportions of {>=}20 vol.-%. By adding fibrous xylite, the fertility of particularly inefficient soils such as, for example, excavation residue, sandy soil, or limestone soil can be improved significantly. (orig.)

  19. FIBROUS DYSPLASIA IN THE MAXILLO-MANDIBULAR REGION – case report

    Directory of Open Access Journals (Sweden)

    Radka Cholakova

    2010-07-01

    Full Text Available Craniofacial fibrous dysplasia is 1 of 3 types of fibrous dysplasia that can affect the bones of the craniofacial complex, including the mandible and maxilla.Fibrous displasia is a skeletal developmental disorder of the bone-forming mesenchyme that manifests as a defect in osteoblastic differentiation and maturation. It is a lesion of unknown etiology, uncertain pathogenesis, and diverse histopathology. Fibrous dysplasia represents about 2, 5% of all bone tumors and over 7% of all benign tumours.The aim of this article is to represent a rare case of bilateral fibrous dysplasia of the upper and lower jaws, in combination with Intellectual disability (previously called mental retardation. The clinical diagnostic approach including imaging studies: Orthopantomogram (OPG and 3D tomography is described. Histological examination was also essential for obtaining a definitive diagnosis.

  20. Electrospun nanocomposite fibrous polymer electrolyte for secondary lithium battery applications

    International Nuclear Information System (INIS)

    Hybrid nanocomposite [poly(vinylidene fluoride -co- hexafluoropropylene) (PVdF-co-HFP)/magnesium aluminate (MgAl2O4)] fibrous polymer membranes were prepared by electrospinning method. The prepared pure and nanocomposite fibrous polymer electrolyte membranes were soaked into the liquid electrolyte 1M LiPF6 in EC: DEC (1:1,v/v). XRD and SEM are used to study the structural and morphological studies of nanocomposite electrospun fibrous polymer membranes. The nanocomposite fibrous polymer electrolyte membrane with 5 wt.% of MgAl2O4 exhibits high ionic conductivity of 2.80 × 10?3 S/cm at room temperature. The charge-discharge capacity of Li/LiCoO2 coin cells composed of the newly prepared nanocomposite [(16 wt.%) PVdF-co-HFP+(5 wt.%) MgAl2O4] fibrous polymer electrolyte membrane was also studied and compared with commercial Celgard separator

  1. Geotechnical Challenges in Numerical Modelling of Sarawak Fibrous Peat

    Directory of Open Access Journals (Sweden)

    Seneviratne Nimal

    2014-12-01

    Full Text Available In Sarawak, about 13% of the total land area is covered with recent peat deposits. A complex mechanism of plant growth and peat accumulation with time has led to formation of flat topped peat domes. Dome centre consists of highly fibrous ombrogeneous peat. Topogeneous peat found in the fringes of peat domes and in interior floodplains, consists of a mixture of decomposed plant matter and fine clastic sediments. Mechanical behaviour of fibrous peat is influenced by the arrangement of fibre. The present study shows that fibrous peat as well as temperate peat conforms to a unique dry density - moisture content relationship. A preliminary study has been carried out in developing a cellular model of fibrous peat. The finite element analysis of time dependent stress strain behaviour performed using this model shows interesting results and promise of application in understanding the behaviour of fibrous peat.

  2. Method of manufacturing fibrous hemostatic bandages

    Science.gov (United States)

    Larsen, Gustavo; Spretz, Ruben; Velarde-Ortiz, Raffet

    2012-09-04

    A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.

  3. Study on fibrous materials for brain phantoms.

    Science.gov (United States)

    Guise, Catarina; Fangueiro, Raul; Nóbrega, João Miguel; Schneider, Walter

    2014-01-01

    Generally, current clinical imaging methods do not provide highly detailed information about location of axonal injury, severity of injury or expected recovery of patients with traumatic brain injury (TBI). High-Definition Fiber Tractography (HDFT) is a novel imaging modality that allows visualizing and quantifying, directly, the degree of axons damage, predicting functional deficits due to traumatic axonal injury and loss of cortical projections. This imaging modality is based on diffusion technology. Being a novel modality, validation and quality control are essential. Thus this study aims at the development of a brain phantom to mimic the human brain in order to fill some gaps that currently exist in this area. This paper is focused on this novel imaging approach, the role of brain phantoms on its validation and the quality control, as well as, on the materials used in their construction. Furthermore, some important characteristics of fibrous materials for brain phantom are also discussed. PMID:25488222

  4. Cutaneous changes in fibrous hamartoma of infancy

    Directory of Open Access Journals (Sweden)

    Pilar F-Eire

    2013-01-01

    Full Text Available Only a few published case of fibrous hamartoma of infancy (FHI have commented on the changes in the overlying skin. There are descriptions of individual cases with cutaneous hyperpigmentation, hypertrichosis and hyperhidrosis. It is interesting to describe our case because, to our knowledge, the altered pigmentation of the overlying skin, with hairs on the surface, and eccrine gland hyperplasia combined with abortive hair follicles has not been reported together in association with the FHI. We recommend that all the biopsies must be excisional including overlying skin, thus the epidermal and dermal adnexal changes can be assessed in the microscopic evaluation which could have relevant implications from clinical and embryological point of view.

  5. Tumor fibroso solitário maligno de extremidades Malignant solitary fibrous tumour of the extremities

    OpenAIRE

    Daniel Chang; Cláudia Regina Gomes Cardim Mendes de Oliveira; Carlos Fernando Saito

    2010-01-01

    Tumor fibroso solitário extrapleural (TFS) é neoplasia mesenquimal rara, sendo que há menos de 40 casos descritos com localização em extremidades até o presente momento. Acomete preferencialmente pacientes na quinta década e não tem predileção por sexo. Relatamos um caso com os aspectos clínicos, radiológicos, histológicos e imunoistoquímicos característicos, discutindo a importância do diagnóstico diferencial com outros sarcomas.Pouco é conhecido sobre o comportamento biológico do TFS. Fator...

  6. Ehlers-Danlos syndrome with monostotic fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Rao A

    1979-01-01

    Full Text Available An unusual case of Ehlers-Danlos syndrome with monostotic fibrous dysplasia of the humorus is presented. The other orthopae-dic manifestations, its complications and associated features are re-viewed and summarised.

  7. Fibrous ingluvial foreign bodies in 33 cockatiels (Nymphicus hollandicus).

    Science.gov (United States)

    Rosenwax, A C; Cowan, M L

    2015-10-01

    The presentation, treatment and outcomes of 33 ingluvial fibrous foreign bodies in cockatiels (Nymphicus hollandicus) are described. Vomiting, lethargy and weight loss were the most common presenting signs. Diagnosis was made on palpation of a mass in the crop (ingluvies). Both surgical and non-surgical treatment regimens were evaluated. The overall mortality rate was 33%, suggesting fibrous materials are not safe for cockatiels to groom or ingest and should not be offered as cage accessories. PMID:26412121

  8. Effects of compression on the sound absorption of fibrous

    DEFF Research Database (Denmark)

    Castagnede, Bernard; Akninen, Achour

    2000-01-01

    During the compression of a fibrous mat, it is well known that the absorption properties are decreasing. In order to predict this change, some heuristic formulae are proposed which take into account the modifications of the physical parameters(porosity, resistivity, tortousity and shappe factors) which enter in the standard "equivalent fluid" model. Numerical predictions are then discussed and compared to experimental data obtained on a fibrous material(uncompressed and the compressed) used in automotive industry.

  9. Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture

    OpenAIRE

    Ifkovits, Jamie L.; Sundararaghavan, Harini G.; Burdick, Jason A

    2009-01-01

    As the field of tissue engineering evolves, there is a tremendous demand to produce more suitable materials and processing techniques in order to address the requirements (e.g., mechanics and vascularity) of more intricate organs and tissues. Electrospinning is a popular technique to create fibrous scaffolds that mimic the architecture and size scale of the native extracellular matrix. These fibrous scaffolds are also useful as cell culture substrates since the fibers can be used to direct ...

  10. Primary hyperparathyroidism having multiple Brown tumors mimicking malignancy

    Directory of Open Access Journals (Sweden)

    Ekram Ullah

    2012-01-01

    Full Text Available Primary hyperparathyroidism is a disease characterized by excessive secretion of parathormone. During the course of this disease, bone loss occurs, particularly depending on resorption of the skeletal system. One of the complications of primary hyperparathyroidism is fibrotic, cystic bony changes which is called Brown tumor. Skeletal manifestations in the form of Brown tumors are rare and according to literature occur in less than 2% of patients suffering from any form of hyperparathyroidism. Such rare and multiple benign lesions may simulate a malignant neoplasm and pose a real challenge for the clinician in its differential diagnosis. We present a case of a 23-year-old Indian woman who was evaluated for multiple lytic expansile lesions with a strong suspicion of malignancy and fibrous dysplasia but turned out to be a case of primary hyperparathyroidism.

  11. Diagnostic validity of the osteoscintigraphy in some non-malignant diseases and fractures of maxillofacial bones

    International Nuclear Information System (INIS)

    In 37 patients with non-malignant diseases or bone fractures of the facial skull 42 osteoscintigraphies were accomplished with /sup 99m/Te labelled 1-hydroxyethylidene-1,1-diphosphonate or /sup 99m/Te labelled methylenediphosphonate. In patients with polyostotic bone diseases such as fibrous osteodysplasia or eosinophilous granuloma it proved more favorable concerning lower radiation doses to perform scintigraphy prior to radiography. (author)

  12. Differences in lectin binding of malignant pleural mesothelioma and adenocarcinoma of the lung.

    OpenAIRE

    Kawai, T.; Greenberg, S. D.; Truong, L. D.; Mattioli, C. A.; Klima, M.; Titus, J. L.

    1988-01-01

    In order to differentiate between malignant pleural mesothelioma and adenocarcinoma of the lung, the glycoconjugate profiles of 6 reactive mesothelial lesions, 23 mesotheliomas (17 epithelial, 1 desmoplastic, 2 biphasic, and 3 fibrous types), and 28 well-differentiated pulmonary adenocarcinomas were evaluated with the use of 8 lectins in addition to anti-carcinoembryonic, anti-keratin and anti-epithelial membrane antigen. Formalin-fixed, paraffin-embedded tissues were stained with the avidin-...

  13. Impregnated Fibrous Materials. Report of a Study Group on Impregnated Fibrous Materials

    International Nuclear Information System (INIS)

    There has recently been renewed interest in the use of radiation from radioisotopes or particle accelerators to initiate and sustain chemical reactions. Particular attention is being paid to the production of wood-plastic composites, a process which is now a commercial reality with radiation competing against chemical methods to enhance the properties of wood. It has been reported that water repellancy, hardness, weathering, insect and chemical resistance, compressive, bending and shear strength can be significantly improved by the process, but so far there has been a limited commercial outlet for the product. Papers on this subject were presented at the International Atomic Energy Agency's Symposium on Industrial Uses of Large Radiation Sources, Salzburg, May 1963, and since then the Agency has been aware of the interest of developing countries in conducting research on wood and other fibrous materials as a means of further exploiting natural resources. It was felt that some attempt should be made to co-ordinate, on a regional basis, the work being done in this field and at the same time review the world status, including the associated technology in such areas as monomer-polymer chemistry and impregnation techniques where they are directly related to this work. Because of the wide range of fibrous materials being studied there, Asia and the Far East was chosen as the most representative area and 39 participants from 13 countries, and from international organizations, met in Bangkok from 20 to 24 November 1967 to assess the potential of impregnated fibrous materials. This report is a record of the meeting and is based not only on work performed both inside and outside the region but also on details of the resources and industries in the area

  14. Silica Microspheres with Fibrous Shells: Synthesis and Application in HPLC.

    Science.gov (United States)

    Qu, Qishu; Min, Yi; Zhang, Lihua; Xu, Qin; Yin, Yadong

    2015-10-01

    Monodispersed silica spheres with solid core and fibrous shell were successfully synthesized using a biphase reaction. Both the thickness and the pore size of the fibrous shell could be finely tuned by changing the stirring rate during synthesis. When stirring was adjusted from 0 to 800 rpm, the thickness of the shell could be tuned from 13 to 67 nm and the pore size from 5 to 16 nm. By continuously adjusting the stirring rate, fibrous shells with hierarchical pore structure ranged from 10 to 28 nm and thickness up to 200 nm could be obtained in one pot. We demonstrate that fibrous shells with controllable thickness and pore size could be coated on silica cores with diameters from 0.5 to 3 ?m while maintaining the monodispersity of the particles. As a result of the unique fibrous structure, the BET surface area could reach ?233 m(2) g(-1) even though the shell thickness was less than 150 nm. The core-shell particles were modified with C18, packed, and then used in high-performance liquid chromatography (HPLC) separation, showing separation performance as high as 2.25 × 10(5) plates m(-1) for naphthalene and back pressure as low as 5.8 MPa. These silica microspheres with fibrous shells are expected to have great potential for practical applications in HPLC. PMID:26321588

  15. Genetics Home Reference: Malignant hyperthermia

    Science.gov (United States)

    ... Recent literature OMIM Genetic disorder catalog Conditions > Malignant hyperthermia On this page: Description Genetic changes Inheritance Diagnosis ... Glossary definitions Reviewed October 2007 What is malignant hyperthermia? Malignant hyperthermia is a severe reaction to particular ...

  16. Intracranial solitary fibrous tumor: Imaging findings

    International Nuclear Information System (INIS)

    Objective: To study the neuroimaging features of intracranial solitary fibrous tumors (ISFTs). Materials and methods: Retrospective study of neuroimaging features of 9 consecutive histopathologically proven ISFT cases. Location, size, shape, density, signal intensity and gadolinium uptake were studied at CT and MRI. Data collected from diffusion-weighted imaging (DWI) (3 patients), perfusion imaging and MR spectroscopy (2 patients), and DSA (4 patients) were also analyzed. Results: The tumors most frequently arose from the intracranial meninges (7/9), while the other lesions were intraventricular. Tumor size ranged from 2.5 to 10 cm (mean = 6.6 cm). They presented multilobular shape in 6/9 patients. Most ISFTs were heterogeneous (7/9) with areas of low T2 signal intensity that strongly enhanced after gadolinium administration (6/8). Erosion of the skull was present in about half of the cases (4/9). Components with decreased apparent diffusion coefficient were seen in 2/3 ISFTs on DWI. Spectroscopy revealed elevated peaks of choline and myo-inositol. MR perfusion showed features of hyperperfusion. Conclusion: ISFT should be considered in cases of extra-axial, supratentorial, heterogeneous, hypervascular tumor. Areas of low T2 signal intensity that strongly enhance after gadolinium injection are suggestive of this diagnosis. Restricted diffusion and elevated peak of myo-inositol may be additional valuable features.

  17. Intracranial solitary fibrous tumor: Imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Clarencon, Frederic, E-mail: fredclare5@msn.com [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Bonneville, Fabrice [Department of Neuroradiology, Hopital Rangueil, Toulouse University Hospital, 31000 Toulouse (France); Rousseau, Audrey [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Galanaud, Damien [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Kujas, Michele [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Naggara, Olivier [Department of Neuroradiology, St Anne Hospital, 75014 Paris (France); Cornu, Philippe [Department of Neurosurgery, Pitie-Salpetriere Hospital (France); Chiras, Jacques [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France)

    2011-11-15

    Objective: To study the neuroimaging features of intracranial solitary fibrous tumors (ISFTs). Materials and methods: Retrospective study of neuroimaging features of 9 consecutive histopathologically proven ISFT cases. Location, size, shape, density, signal intensity and gadolinium uptake were studied at CT and MRI. Data collected from diffusion-weighted imaging (DWI) (3 patients), perfusion imaging and MR spectroscopy (2 patients), and DSA (4 patients) were also analyzed. Results: The tumors most frequently arose from the intracranial meninges (7/9), while the other lesions were intraventricular. Tumor size ranged from 2.5 to 10 cm (mean = 6.6 cm). They presented multilobular shape in 6/9 patients. Most ISFTs were heterogeneous (7/9) with areas of low T2 signal intensity that strongly enhanced after gadolinium administration (6/8). Erosion of the skull was present in about half of the cases (4/9). Components with decreased apparent diffusion coefficient were seen in 2/3 ISFTs on DWI. Spectroscopy revealed elevated peaks of choline and myo-inositol. MR perfusion showed features of hyperperfusion. Conclusion: ISFT should be considered in cases of extra-axial, supratentorial, heterogeneous, hypervascular tumor. Areas of low T2 signal intensity that strongly enhance after gadolinium injection are suggestive of this diagnosis. Restricted diffusion and elevated peak of myo-inositol may be additional valuable features.

  18. Peripheral ameloblastoma with histologically low-grade malignant features of the buccal mucosa: a case report with immunohistochemical study and genetic analysis

    OpenAIRE

    Goda, Hiroyuki; Nakashiro, Kohichi; Ogawa, Ikuko; TAKATA, Takashi; Hamakawa, Hiroyuki

    2015-01-01

    Peripheral ameloblastoma (PA), a rare and unusual variant of odontogenic tumors, comprises about 1% of all ameloblastomas. PA is an exophytic growth localized to the soft tissues overlying the tooth-bearing areas of the jaws, and the initial diagnosis is often fibrous epulis. PA with histologically low-grade malignant features is extremely rare. We report a case of peripheral ameloblastoma with histologically low-grade malignant features in a 69-year-old woman that presented with a hemorrhage...

  19. A call to expand regulation to all carcinogenic fibrous minerals

    Science.gov (United States)

    Baumann, F.; Steele, I.; Ambrosi, J.; Carbone, M.

    2013-05-01

    The regulatory term "asbestos" groups only the six fibrous minerals that were commercially used among approximately 400. The carcinogenicity of these six regulated minerals has been largely demonstrated and is related to fiber structure, fiber length/diameter ratio, and bio-persistence. From a public perception, the generic term "asbestos" refers to the fibrous minerals that cause asbestosis, mesothelioma and other cancers. However, other non-regulated fibrous minerals are potentially as dangerous as the regulatory asbestos because they share similar physical and chemical properties, epidemiological studies have demonstrated their relationship with asbestos-related diseases, and both in vitro and in vivo experiments have established the toxicity of these minerals. For example, the non-regulated asbestiform winchite and richterite minerals that contaminated the vermiculite mined from Libby, Montana, (USA) were associated with mesothelioma, lung cancer and asbestosis observed among the area's residents and miners. Many other examples of non-regulated carcinogenic fibrous minerals include, but are not limited to, antigorite, arfvedsonite, balangeroite, carlosturanite, erionite, fluoro-edenite, hornblende, mordenite, palygorskite, and sepiolite. To propose a regulatory definition that would provide protection from all carcinogenic fibers, we have conducted an interdisciplinary literature review to compare the characteristics of "asbestos" and of non-regulated mineral fibers that relate to carcinogenicity. We specifically studied two non-regulated fibrous minerals that are associated with asbestos-related diseases: the serpentine antigorite and the zeolite erionite. Both examples underscore the problem of regulation based on commercial, rather than scientific principles: 1) the occurrence of fibrous antigorite in materials used to pave roads has been correlated with high mesothelioma rates in New Caledonia. Antigorite was also the cause of asbestosis in Poland, and in vitro and in vivo studies have shown its toxic and carcinogenic properties; 2) the carcinogenic properties of erionite have been demonstrated, and erionite has been associated with a mesothelioma epidemic in Anatolia, Turkey. Erionite is also widespread in areas of north central USA, where it is contained in gravel paving stone, and is cause for concern due to increased commercial traffic. Numerous studies have shown that non-regulated fibrous materials pose similar health hazards to regulated "asbestos". An increase in human activities in areas where these fibrous minerals are present, such as in surficial rock and soil, will result in the generation of airborne dust, exposing people to carcinogenic fibers. The current limited regulation leads people to believe that only the six mineral fibers referred to as "asbestos" are dangerous. We propose that fibrous minerals should be regulated as a single group, as they have similar deleterious effects on the human body. Regulations would be simplified and more effective if they embrace all carcinogenic fibrous minerals.

  20. Diffuse reflectance spectroscopy of fibrous proteins.

    Science.gov (United States)

    Millington, Keith R

    2012-09-01

    UV-visible diffuse reflectance (DR) spectra of the fibrous proteins wool and feather keratin, silk fibroin and bovine skin collagen are presented. Natural wool contains much higher levels of visible chromophores across the whole visible range (700-400 nm) than the other proteins and only those above 450 nm are effectively removed by bleaching. Both oxidative and reductive bleaching are inefficient for removing yellow chromophores (450-400 nm absorbers) from wool. The DR spectra of the four UV-absorbing amino acids tryptophan, tyrosine, cystine and phenylalanine were recorded as finely ground powders. In contrast to their UV-visible spectra in aqueous solution where tryptophan and tyrosine are the major UV absorbing species, surprisingly the disulphide chromophore of solid cystine has the strongest UV absorbance measured using the DR remission function F(R)(?). The DR spectra of unpigmented feather and wool keratin appear to be dominated by cystine absorption near 290 nm, whereas silk fibroin appears similar to tyrosine. Because cystine has a flat reflectance spectrum in the visible region from 700 to 400 nm and the powder therefore appears white, cystine absorption does not contribute to the cream colour of wool despite the high concentration of cystine residues near the cuticle surface. The disulphide absorption of solid L: -cystine in the DR spectrum at 290 nm is significantly red shifted by ~40 nm relative to its wavelength in solution, whereas homocystine and lipoic acid showed smaller red shifts of 20 nm. The large red shift observed for cystine and the large difference in intensity of absorption in its UV-visible and DR spectra may be due to differences in the dihedral angle between the crystalline solid and the solvated molecules in solution. PMID:22218994

  1. Imaging malignant and apparent malignant transformation of benign gynaecological disease

    Energy Technology Data Exchange (ETDEWEB)

    Lee, A.Y.; Poder, L.; Qayyum, A.; Wang, Z.J.; Yeh, B.M. [Department of Radiology, University of California San Francisco, San Francisco, CA (United States); Coakley, F.V., E-mail: Fergus.Coakley@radiology.ucsf.ed [Department of Radiology, University of California San Francisco, San Francisco, CA (United States)

    2010-12-15

    Common benign gynaecological diseases, such as leiomyoma, adenomyosis, endometriosis, and mature teratoma, rarely undergo malignant transformation. Benign transformations that may mimic malignancy include benign metastasizing leiomyoma, massive ovarian oedema, decidualization of endometrioma, and rupture of mature teratoma. The aim of this review is to provide a contemporary overview of imaging findings in malignant and apparent malignant transformation of benign gynaecological disease.

  2. Imaging malignant and apparent malignant transformation of benign gynaecological disease.

    Science.gov (United States)

    Lee, A Y; Poder, L; Qayyum, A; Wang, Z J; Yeh, B M; Coakley, F V

    2010-12-01

    Common benign gynaecological diseases, such as leiomyoma, adenomyosis, endometriosis, and mature teratoma, rarely undergo malignant transformation. Benign transformations that may mimic malignancy include benign metastasizing leiomyoma, massive ovarian oedema, decidualization of endometrioma, and rupture of mature teratoma. The aim of this review is to provide a contemporary overview of imaging findings in malignant and apparent malignant transformation of benign gynaecological disease. PMID:21070909

  3. Gastrointestinal Malignancies Faculty

    Science.gov (United States)

    Mission Statement The Gastrointestinal Malignancies Faculty (GMF) facilitates interactions among basic, epidemiological, translational, and clinical researchers promoting a community of investigators working together for the prevention, diagnosis, and cur

  4. Brain Malignancies Steering Committee

    Science.gov (United States)

    The Brain Malignancy Steering Committee evaluates and prioritizes concepts for phase 3 and large phase 2 therapeutic clinical trials to be conducted in the NCI National Clinical Trials Network (NCTN).

  5. Keratomycotic malignant glaucoma

    OpenAIRE

    Kuriakose Thomas; Thomas Philip

    1991-01-01

    Malignant Glaucoma due to Keratomycosis is a devastating and poorly recognised complication occurring in a small percentage of treated patients. It is characterized, in cases of Keratomycosis by a raised tension, uniform shallowing of the anterior chamber and a fungus-exudate-iris mass covering the pupillary area. Three cases of ?Keratomycotic Malignant Glaucoma? are discussed here. Two of these were successfully treated with therapeutic keratoplasty, extracapsular lens extracti...

  6. Primary Malignant Rhabdoid Melanoma

    OpenAIRE

    Chung, Bo Young; Ahn, In Su; Cho, Soo Ick; Kim, Hye One; Kim, Kwang Ho; Park, Chun Wook; Lee, Cheol Heon

    2011-01-01

    Melanoma with rhabdoid features is an uncommon variant of malignant melanoma. Here, we describe a rare case of primary rhabdoid malignant melanoma. A 54-year-old man presented with a black tumor measuring 3×4 cm on the right forearm. Histologic sections showed a tumor mass with rhabdoid features composed entirely of polygonal neoplastic cells with eccentric nuclei, prominent nucleoli, and large hyaline cytoplasmic inclusions. The tumor cells were immunoreactive with HMB-45, S100, Fontana-Mass...

  7. Malignant vagal paraganglioma

    DEFF Research Database (Denmark)

    Carlsen, Camilla S; Godballe, Christian; Krogdahl, Annelise S; Edal, Anette L

    2003-01-01

    Approximately 20 cases of malignant vagal paragangliomas (MVP)have been reported in English literature. Malignancy is based on the presence of metastases. A careful preoperative evaluation is necessary to detect multicentricity and/or significant production of catecholamines. A new case of MVP treated with embolization and surgery is presented and the literature discussed. It is concluded, that preoperative embolization followed by radical surgical resection is a rational treatment of patients w...

  8. Håndens maligne tumorer

    DEFF Research Database (Denmark)

    Knudsen, Britt Mejer; Rasmussen, Per Joen Svabo; Lausten, Gunnar Schwarz; Jensen, Nina Vendel; Nielsen, Niels Søe

    2011-01-01

    Malignant tumours of the hand are rare and are often misdiagnosed. A painful swelling of the hand or digits are often diagnosed with an infection, benign tumours such as ganglion cysts, or arthritis. Wounds that do not heal despite adequate treatment should be biopsied to rule out malignancy. A correct diagnosis without delay is important because the life expectancy, due to a metastasis on the hand or fingers is approximately six months.

  9. Primary Malignant Tumours of Bone Following Previous Malignancy

    OpenAIRE

    Grimer, R. J; Sommerville, S. M. M.; Patton, J. T.

    2008-01-01

    Destructive bone lesions occurring in patients who have previously had a malignancy are generally assumed to be a metastasis from that malignancy. We reviewed 60 patients with a previous history of malignancy, who presented with a solitary bone lesion that was subsequently found to be a new and different primary sarcoma of bone. These second malignancies occurred in three distinct groups of patients: (1) patients with original tumours well known to be associated with second malignancies (5%)...

  10. Management of malignant pleural effusions.

    LENUS (Irish Health Repository)

    Uzbeck, Mateen H

    2010-06-01

    Malignant pleural effusions are a common clinical problem in patients with primary thoracic malignancy and metastatic malignancy to the thorax. Symptoms can be debilitating and can impair tolerance of anticancer therapy. This article presents a comprehensive review of pharmaceutical and nonpharmaceutical approaches to the management of malignant pleural effusion, and a novel algorithm for management based on patients\\' performance status.

  11. Craniofacial fibrous dysplasia - A review of current management techniques

    Directory of Open Access Journals (Sweden)

    Yadavalli Guruprasad

    2012-01-01

    Full Text Available Fibrous dysplasia is a pathologic condition of bone of unknown etiology with no apparent familial, hereditary or congenital basis. Lichtenstein first coined the term in 1938 and in 1942 he and Jaffe separated it from other fibro-osseous lesions. It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton. Its management poses significant challenges to the surgeon. Craniofacial fibrous dysplasia is 1 of 3 types of fibrous dysplasia that can affect the bones of the craniofacial complex, including the mandible and maxilla. Fibrous dysplasia is a skeletal developmental disorder of the bone-forming mesenchyme that manifests as a defect in osteoblastic differentiation and maturation. It is a lesion of unknown etiology, uncertain pathogenesis, and diverse histopathology. Fibrous dysplasia represents about 2, 5% of all bone tumors and over 7% of all benign tumours. Over the years, we have gained a better understanding of its etiology, clinical behavior, and both surgical and non-surgical treatments.

  12. Oxidative stress inhibition and oxidant activity by fibrous clays.

    Science.gov (United States)

    Cervini-Silva, Javiera; Nieto-Camacho, Antonio; Gómez-Vidales, Virginia

    2015-09-01

    Fibrous clays (sepiolite, palygorskite) are produced at 1.2m tonnes per year and have a wide range of industrial applications needing to replace long-fibre length asbestos. However, information on the beneficial effects of fibrous clays on health remains scarce. This paper reports on the effect of sepiolite (Vallecas, Spain) and palygorskite (Torrejón El Rubio, Spain) on cell damage via oxidative stress (determined as the progress of lipid peroxidation, LP). The extent of LP was assessed using the Thiobarbituric Acid Reactive Substances assay. The oxidant activity by fibrous clays was quantified using Electron-Paramagnetic Resonance. Sepiolite and palygorskite inhibited LP, whereby corresponding IC50 values were 6557±1024 and 4250±289?gmL(-1). As evidenced by dose-response experiments LP inhibition by palygorskite was surface-controlled. Fibrous clay surfaces did not stabilize HO species, except for suspensions containing 5000?gmL(-1). A strong oxidant (or weak anti-oxidant) activity favours the inhibition of LP by fibrous clays. PMID:26071933

  13. Electrospun nanocomposite fibrous polymer electrolyte for secondary lithium battery applications

    Energy Technology Data Exchange (ETDEWEB)

    Padmaraj, O.; Rao, B. Nageswara; Jena, Paramananda; Satyanarayana, N., E-mail: nallanis2011@gmail.com [Department of Physics, Pondicherry University, Pondicherry-605014 (India); Venkateswarlu, M. [R and D, Amaraja batteries, Thirupathi-517501 (India)

    2014-04-24

    Hybrid nanocomposite [poly(vinylidene fluoride -co- hexafluoropropylene) (PVdF-co-HFP)/magnesium aluminate (MgAl{sub 2}O{sub 4})] fibrous polymer membranes were prepared by electrospinning method. The prepared pure and nanocomposite fibrous polymer electrolyte membranes were soaked into the liquid electrolyte 1M LiPF{sub 6} in EC: DEC (1:1,v/v). XRD and SEM are used to study the structural and morphological studies of nanocomposite electrospun fibrous polymer membranes. The nanocomposite fibrous polymer electrolyte membrane with 5 wt.% of MgAl{sub 2}O{sub 4} exhibits high ionic conductivity of 2.80 × 10{sup ?3} S/cm at room temperature. The charge-discharge capacity of Li/LiCoO{sub 2} coin cells composed of the newly prepared nanocomposite [(16 wt.%) PVdF-co-HFP+(5 wt.%) MgAl{sub 2}O{sub 4}] fibrous polymer electrolyte membrane was also studied and compared with commercial Celgard separator.

  14. Case for diagnosis

    Scientific Electronic Library Online (English)

    Felipe Maurício Soeiro, Sampaio; Gustavo Vieira, Gualberto; Fernando Gustavo Mósca de, Cerqueira; Ana Maria Mósca de, Cerqueira; Curt Mafra, Treu; Thiago Jeunon de Sousa, Vargas.

    2014-06-01

    Full Text Available We report the case of an 11-year-old male patient with a histopathological and immunohistochemical diagnosis of dermatofibroma with an atypical clinical presentation on the right forearm. Although dermatofibroma is considered a benign skin tumor, some of its differential diagnoses, such as dermatofi [...] brosarcoma protuberans and malignant fibrous histiocytoma, are truly aggressive. Lesions with atypical clinical aspects and topology associated with specific histopathological variants are some of the criteria for complete tumor excision.

  15. Case for diagnosis Caso para diagnóstico

    OpenAIRE

    Mariana Hammerschmidt; Luciana Menezes de Azevedo; Anelisa Ruaro; Betina Werner; Alexandre do Nascimento; Ézio Augusto Amaral Filho

    2012-01-01

    Atypical fibroxanthoma is a rare cutaneous tumor found mainly in elderly people on sun-exposed areas of the body. Histologically, atypical fibroxanthoma is considered a malignant fibrous histiocytoma with bizarre neoplastic cells, marked pleomorphism, hyperchromatic nuclei and abundant mitoses. It must be differentiated from other skin tumors, usually by immunohistochemistry, since its diagnosis is made by exclusion.O fibroxantoma atípico é um tipo de neoplasia cutânea maligna rara, encontrad...

  16. Giant cell tumour of peroneus brevis tendon sheath – a case report and review of literature

    OpenAIRE

    Goni, Vijay; Gopinathan, Nirmal Raj; Radotra, B. D.; Viswanathan, Vibhu Krishnan; Logithasan, Rajesh Kumar; S., Balaji

    2012-01-01

    Giant cell tumour of tendon sheath is a benign soft tissue lesion most commonly found in the flexor aspect of hand and wrist. Being rare in foot and ankle, the unusual presentation of this lesion may sometimes mimic other lesions like lipoma, synovial sarcoma, malignant fibrous histiocytoma, synovial cyst and ganglion. Hence it is important to include this lesion in differential diagnoses especially if the lesion is found to be anchored to any of the surrounding tendons. This article describe...

  17. A case of intermittent lumbar pain radiating to the right shoulder in a 76-year-old woman.

    Science.gov (United States)

    Cardinale, Luciano; Ardissone, Francesco; Familiari, Ubaldo; Perna, Mariaelena; Fava, Cesare

    2009-09-01

    Malignant fibrous histiocytoma (MFH) is a pleomorphic sarcoma, occurring most frequently in the deep soft tissues of the extremities, and it is most frequently seen in elderly patients. A primary MFH of the diaphragm is very rare, and to the best of our knowledge, a multi-phased spiral CT appearance of this tumour has not been previously reported. In this report, we describe the clinical and multi-phase CT features of a primary MFH of the diaphragm. PMID:19626327

  18. Long-term survivor of relapsed MFH on the thigh treated with autologous formalin-fixed tumor vaccine (AFTV) combined with limb-sparing surgery and radiotherapy

    OpenAIRE

    Todoroki, Takeshi; KONDO, TADASHI; SUGAHARA, SHINJI; Morishita, Yukio; Mori, Kensaku; Ohno, Tadao

    2011-01-01

    Malignant fibrous histiocytoma (MFH) is an aggressive spindle cell cancer of soft-tissue sarcoma type in the elderly, mostly affecting the extremities. Lesions > 5 cm, positive margins, and local recurrence are significant poor prognostic indicators. The strongest predictor for distant metastasis was tumor size (> 5 cm), and for overall survival, presence of local recurrence. Limb-sparing extensive tumor resection is preferred to achieve negative surgical margins. However, in some circumstanc...

  19. Long-term survivor of relapsed MFH on the thigh treated with autologous formalin-fixed tumor vaccine (AFTV) combined with limb-sparing surgery and radiotherapy

    OpenAIRE

    Morishita Yukio; Sugahara Shinji; Kondo Tadashi; Todoroki Takeshi; Mori Kensaku; Ohno Tadao

    2011-01-01

    Abstract Malignant fibrous histiocytoma (MFH) is an aggressive spindle cell cancer of soft-tissue sarcoma type in the elderly, mostly affecting the extremities. Lesions > 5 cm, positive margins, and local recurrence are significant poor prognostic indicators. The strongest predictor for distant metastasis was tumor size (> 5 cm), and for overall survival, presence of local recurrence. Limb-sparing extensive tumor resection is preferred to achieve negative surgical margins. However, in some ci...

  20. Total hip replacement for proximal femoral tumours: our midterm results

    OpenAIRE

    Sokolovski, V. A.; Voloshin, V. P.; Aliev, M. D.; Zubikov, V. S.; Saravanan, S. A.; Martynenko, D. V.; Nisichenko, D. V.; Strelnikov, K. N.

    2006-01-01

    Data from 44 patients (23 males, 21 females) with a median age of 39 (range 13–80) years who underwent total hip arthroplasty for proximal femoral tumours (1994–2004) were analysed. The histological diagnoses included 14 metastases, six osteosarcomas, six chondrosarcomas, four Ewing’s sarcomas, four giant cell tumours, three malignant fibrous histiocytomas, two parosteal and two periosteal osteosarcomas, and one each primary neuroectodermal tumour, myeloid disease, and aneurysmal bone cyst. T...

  1. Current Concepts and Surgical Aspects of Extremity Bone and Soft Tissue Sarcoma

    OpenAIRE

    Ham, Simon Johannes,

    1999-01-01

    On the basis of 25 years of experience with the managment of extremity sarcomas at the University Hospital Groningen, the Netherlands, this thesis aimed: to discuss the development and results of multidisciplinary treatment in extremity soft tissue sarcoma and osteosarcoma; to investigate the long-term results of the combined treatment of high-dose methotrexate-based neoadjuvant chemotherapy and surgery in malignant fibrous histiocytoma of bone; to assess the long-term oncological and functio...

  2. Frontorbital Fibrous Dysplasia Resection and Reconstruction With Custom Polyetherlatone Alloplast.

    Science.gov (United States)

    Nahumi, Nadav; Shohet, Michael R; Bederson, Joshua B; Elahi, Ebrahim

    2015-11-01

    Fibrous dysplasia (FD) is a benign, pathological development of bone. Craniofacial bones are the most commonly involved and can potentially cause visual disturbance, proptosis, orbital dystopia, and facial deformity. This case involves a 13-year-old girl with significant proptosis (20?mm left, 17.5?mm right) and downward displacement of the left globe (1.5?mm) due to fibrous dysplasia. Reconstruction was performed with computed tomography-derived and 3D printed custom polyetheretherketone (PEEK) implantation. PEEK is a nonabsorbable, nonporous thermoplastic polymer notable for its ability to be modified intraoperatively and ideal imaging properties postoperatively. Never, to our knowledge, has PEEK been used for primary reconstruction of the frontal orbital region in fibrous dysplasia in a child. The lesion was successfully repaired with excellent aesthetic and no apparent damage to neurovascular or ocular structures. PMID:26594985

  3. Fibrous dysplasia of the jaws: a case report.

    Science.gov (United States)

    Chindia, M L

    1991-04-01

    This article reviews the present clinical, radiographic and histologic features of fibrous dysplastic lesions of the jaws. A case is presented of an apparently reactivated fibrous dysplastic jaw lesion, with evidence of cystic degeneration, in a 33-year-old female school-teacher who was first seen at the Department of Dental Surgery, University of Nairobi in March 1986. The dilemma in the management of fibrous dysplasia is reviewed and discussed. It is noted that while conservative surgical procedures remain the treatment of choice, situations arise where tremendous tissue activity would require early intervention by numerous cosmetic surgical shaving procedures. The present case, however, offers a unique management challenge due to the occurrence of extensive cystic degeneration in the mandible. PMID:1914982

  4. Radiological analysis of polyostotic fibrous dysplasia in skeletal system

    International Nuclear Information System (INIS)

    Over a period of recent 3 years, the 5 cases of polyostotic fibrous dysplasia were proven histologically at National Medical Center, and they were evaluated and analyzed radiologically and clinically. The results were as follows: 1. The age of 5 patients ranged from 12 to 21. 2. In general, clinical symptoms of these patients were pain of affected sites and swelling , fracture, walking disturbance of lower extremities. 3. The order of frequent site of polyostotic fibrous dysplasia was skull (4 cases), femur (3 cases), maxilla (2 case), humerus, tibia, rib, radius, metacarpal bone and phalanx. 4. The characteristic radiological findings of polyostotic fibrous dysplasia were multicystic lesions with ground glass appearance, osteosclerosis, cortical thinning and pathologic fracture and deformity of long bones. Particularly, in the extremities, multicystic radiolucencies, groud glass appearance, shepherd's crook and coxa vara deformities were noticed, and in the skull and maxilla, sclerotic changes were principally demonstrated.

  5. A solitary fibrous tumor of the retroperitoneum: CT findings

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Min; Kim, Chong Soo; Lee, Dong Keun; Cho, Baek Hwan [Chonbuk National Univ. College of Medicine, Chunju (Korea, Republic of); Han, Hyun Young [Euljy Mecical School, Seoul (Korea, Republic of)

    1999-01-01

    The solitary fibrous tumor is a rare spindle cell neoplasm of mesodermal origin. It usually arises in the pleura, though has recently been reported in the peritoneum and at nonserosal sites ; it is, however, extremely rare in the retroperitonum. The authors describe one case of a solitary fibrous tumor that occurred as a huge complex mass in the retroperitoneum of an adult. Preenhanced CT scans showed that the mass was sharply delineated from surrounding organs and that tumor density was the same as that of surrounding musculature. Peripheral Calcifications were noted, and postenhanced scans showed intense, gradual enhancement of solid portions of the mass, with nonenhanced cystic portions. Although not specific, solitary fibrous tumors must be included in the differential diagnosis of a large retroperitoneal tumor of complex consistency and with internal calcification.

  6. Efficacy of trabectedin in metastatic solitary fibrous tumor

    Directory of Open Access Journals (Sweden)

    Loic Chaigneau

    2011-07-01

    Full Text Available Solitary fibrous tumor is a rare tumor type and has an unpredictable course. Local recurrence rate varies between 9 and 19 %, and rate of metastatic involvement between 0 and 36 %. It is characterized by a typical architecture and immuno-histochemistry tests. The most important prognostic factor is the complete resection of primary tumor. Treatment of recurrences is not clearly established. If a solitary fibrous tumor is too advanced to allow surgical resection, radiotherapy and chemotherapy may be used. The most often used drugs are doxorubicine and\\or ifosfamide. We report the case of man with metastatic solitary fibrous tumor treated with trabectedin, administered at a dose of 1.5 mg/m² every 3 weeks. After 3 cycles, metastases had significantly decreased. Recurrence of the disease was demonstrated 8 months after the start of trabectedin. This case shows that trabectedin is a possible treatment option.

  7. Polyostotic Fibrous Dysplasia of Cranio-Maxillofacial Area

    International Nuclear Information System (INIS)

    Fibrous dysplasia is believed to be a hamartomatous developmental lesion of unknown origin. This disease is divided into monostotic and polyostotic fibrous dysplasia. Polyostotic type can be divided into craniofacial type, Lichtenstein-Jaffe type, and McCune-Albright syndrome. In this case, a 31-year-old female presented spontaneous loss of right mandibular teeth before 5 years and has shown continuous expansion of right mandibular alveolus. Through the radiographic view, the coarse pattern of the mixed radiopaque-lucent lesion was seen on the right mandibular body, and there was diffuse pattern of the mixed radiopaque-lucent lesion with ill-defined margin in the left mandibular body. In the right calvarium, the lesion had cotton-wool appearance. Partial excision for contouring, multiple extraction, and alveoloplasty were accomplished under general anesthesia for supportive treatment. Finally we could conclude this case was polyostotic fibrous dysplasia of cranio-maxillofacial area based on the clinical, radiologic finding, and histopathologic examination.

  8. Primary Malignant Tumours of Bone Following Previous Malignancy

    Directory of Open Access Journals (Sweden)

    R. J. Grimer

    2008-04-01

    Full Text Available Destructive bone lesions occurring in patients who have previously had a malignancy are generally assumed to be a metastasis from that malignancy. We reviewed 60 patients with a previous history of malignancy, who presented with a solitary bone lesion that was subsequently found to be a new and different primary sarcoma of bone. These second malignancies occurred in three distinct groups of patients: (1 patients with original tumours well known to be associated with second malignancies (5%; (2 patients whose second malignancies were likely to be due to the previous treatment of their primary malignancy (40%; (3 patients in whom there was no clearly defined association between malignancies (55%. The purpose of this study is to emphasise the necessity for caution in assuming the diagnosis of a metastasis when a solitary bone lesion is identified following a prior malignancy. Inappropriate biopsy and treatment of primary bone sarcomas compromises limb salvage surgery and can affect patient mortality.

  9. Aggressive malignant abdominal mesothelioma: Clinical report

    International Nuclear Information System (INIS)

    A 32-year-old Filipino female, working as an x-ray technician, presented to the Emergency Room (ER) with acute abdominal pain for one day. The pain was mainly on the left side and left hypochondrium. She had recurring abdominal pain before but not significant to worry her. She also complained of abdominal distension, which she noticed one week ago. Abdominal examination revealed fullness in the left hypochondrium with marked tenderness but negative rebound. Abdominal ultrasound (US) showed a huge mass mainly in the left hypochondrium. The origin of the mass cannot be identified by US. A computerized tomography scan showed a mass in the left side of the abdomen crossing the midline with a necrotic centre. The hospital course of the patient runs smoothly, and she was discharged after 7-days and referred to an Oncology Center. Abdominal mesothelioma is a neoplasm arising from the mesothelial surface lining the abdominal cavity. It is less frequent than that of the pleura. It is a rapidly growing and fatal malignancy with a median survival of less than 1-year. The relation between pleural malignant mesothelioma and asbestos is well recognized since it was described in 19602 but implication of asbestos exposure in the etiology of the peritoneal type is less obvious. This patient history is giving no obvious exposure to asbestos but as she is working in the Radiology Department as an x-ray technician she is well exposed to x-ray, but the effect of radioactivity on induction of mesothelioma is still disputed.4 There are several reports linking malignant mesothelioma to radioactivity due to radiation therapy.The fibrous mesothelioma (sarcomatous), as in this case, which is difficult to diagnose microscopically, looks like a fibroma, unless helped by tissue culture. The treatment options of malignant mesothelioma include surgery, intraperitoneal chemotherapy and whole abdominal radiation or multimodality therapy, which were suggested that might prolong the survival in patients with peritoneal mesothelioma.5 Although peritoneal mesothelioma is rare, progress in its management has occurred, survival has been extended and selection factors by which patients may be allocated to aggressive management strategies have been defined

  10. [Diabetes mellitus and malignancies].

    Science.gov (United States)

    Petera, Ji?í; Smahelová, Alena

    2014-01-01

    The epidemiological studies have proven an increased incidence of cancer in patients with diabetes and the ne-gative effect of diabetes on their prognosis. The relation to type 2 diabetes was found in hepatic, pancreatic and endometrial malignancies, in colorectal, breast and bladder cancers. Diabetes as well as malignancies are multifactorial diseases with a number of common risk factors: age, gender, race, overweight and obesity, diet, physical activity. A higher incidence of malignancies in diabetic patients is not only a result of sharing these risk factors, as diabetes itself predisposes to carcinoma development. Possible mechanisms producing this effect include hyperinsulinemia, hyperglycemia, oxidative stress, chronic inflammation, obesity related factors and effect of diabetic complications. The development of malignancies in diabetics is also affected by the diabetes treatment. Exogenous insulin and its analogues and stimulators of insulin secretion are linked to an increased risk of cancer while insulin sensitizers to its decrease. Special attention is given to metformin which, apart from the indirect effect by influencing the levels of insulin and glycemia, has a direct anticancerogenic effect. In the clinical practice, it is ne-cessary to give attention to the screening of diabetes related tumours, consistent glycemic control and choice of appropriate diabetes treatment in patients with a high cancer risk.Key words: clinical practice - diabetes mellitus - effects of diabetes treatment - malignancies. PMID:25389098

  11. New nitrogen-phosphorus-containing fibrous ionites for water purification

    International Nuclear Information System (INIS)

    New nitrogen-containing nitron fiber based fibrous ionites, which are effective sorbents of heavy and non-ferrous metals from aqueous solutions containing salts CuCl, NiCl2, CoCl2, ZnCl2, CdCl2, Pb(NO3)2 in dynamic conditions, have been prepared as a result of two-phase synthesis. Sorption of cadmium ions from dilute solutions containing calcium ions as in static so dynamic conditions is possible. High sorption activity, good kinetic properties and convenient form of fibrous ionites for the separation of heavy metals are demonstrated by means of conducted investigations

  12. Spatial variability of void structure in thin stochastic fibrous materials

    CERN Document Server

    Sampson, William W

    2011-01-01

    Theory is presented for the distributions of local process intensity and local average pore dimensions in random fibrous materials. For complete partitioning of the network into contiguous square zones, the variance of local process intensity is shown to be proportional to the mean process intensity and inversely proportional to the zone size. The coefficient of variation of local average pore area is shown to be approximately double that of the local average pore diameter with both properties being inversely proportional to the square root of zone size and mean process intensity. The results have relevance to heterogenous near-planar fibrous materials including paper, nonwoven textiles, nanofibrous composites and electrospun polymer fibre networks.

  13. PET in uterine malignancies

    OpenAIRE

    Valeria Pirro; Andrea Skanjeti; Ettore Pelosi

    2010-01-01

    Positron Emission Tomography (PET) or integrated PET/Computed Tomography (PET/CT) with 18F-Fluoro-Deoxy-Glucose (18F-FDG) is a functional imaging modality, useful in the characterization of undetermined morphological findings, and in the staging/re-staging of a large number of malignancies. Although its use in uterine malignancies has been poorly investigated, in recent years the employment of this technique has constantly increased. In this review, we evaluate the role of PET (/CT) with 18FF...

  14. Pediatric Head and Neck Malignancies.

    Science.gov (United States)

    Qaisi, Mohammed; Eid, Issam

    2016-02-01

    Head and neck malignancies are rare in pediatric patients, and represent 12% of all pediatric malignancies. The incidence for these head and neck tumors is 1.49 cases per 1,000,000 person-years. Among the most common pediatric head and neck malignancies are lymphomas (27%), neural tumors including primitive neurectodermal tumors (23%), thyroid malignancies (21%), soft tissue sarcomas including rhabdomyosarcoma (12%), nasopharyngeal carcinoma, skeletal and odontogenic malignancies including osteosarcoma, Ewing sarcoma, and ameloblastic carcinoma. This article presents an overview of pediatric head and neck malignancies with emphasis on diagnosis and management. PMID:26614697

  15. Neurofibromatosis and fibrous dysplasia manifesting in the same patient: a rare case report.

    Science.gov (United States)

    Sujatha, Sampangi; Jatti, Deepa

    2015-02-01

    Neurofibromatosis and fibrous dysplasia show the presence of café-au-lait spots, bone lesions, and endocrinopathies. There has been speculation whether neurofibromatosis and fibrous dysplasia are different manifestations of the same disease or if these conditions are in some way related. We provide a case of whether neurofibromatosis and fibrous dysplasia complicated by hyperparathyroidism and osteoporosis. PMID:24000123

  16. Focal fibrous hyperplasia: A review of 193 cases

    Directory of Open Access Journals (Sweden)

    Thiago de Santana Santos

    2014-01-01

    Full Text Available Context: Focal fibrous hyperplasia, also known as irritation or traumatic fibroma, is a reactive, inflammatory hyperplastic lesion of the connective tissue. Aim: The aim of this study is to perform a retrospective study of a focal fibrous hyperplasia of 18 years. Materials and Methods: We retrospectively reviewed 193 cases of focal fibrous hyperplasia of the oral cavity from the medical and histological reports of the Department of Oral Pathology, Pernambuco University, Brazil, during the period between January 1992 and December 2009. Settings and Design: Data with regard to age, gender, location, size of the lesion (equal to or less than 1 cm, between 1 and 2 cm and greater than 2 cm, pain, history of trauma, treatment, length of follow-up (from diagnosis to release or last review and recurrence, were collected. Results: The most commonly affected site was the buccal mucosa (n = 119, 61.7%. Almost two-thirds of the cases were concentrated from the second to the fifth decade of life. Females were more affected than men and a history of trauma was related by 90.7% of the patients. Two recurrences were notified (1.0%. Conclusion: Further studies are needed on the distribution of the lesion in different ethnic and geographical populations. The influence of sex hormones on the development of focal fibrous hyperplasia must be clarified.

  17. Fibrous sorbents for purification of liquids from cesium radionuclides

    International Nuclear Information System (INIS)

    The properties of fibrous sorbent prepared on the basis of viscose and iron(3) ferrocyanide and intended for liquid media purification, natural milk, in particular, which has been naturally contaminated, from cesium radionuclides, when analyzing water and other liquids at pH 4-6.5, have been considered. 12 refs., 3 figs., 4 tabs

  18. Mesenchymal chondrosarcoma arising in fibrous dysplasia of the femur.

    OpenAIRE

    Blackwell, J B

    1993-01-01

    The occurrence of mesenchymal chondrosarcoma in an area of fibrous dysplasia in the upper femur of a 28 year old man is reported. It is believed that this is the first documented example of such an association. A further unusual feature is the presence of benign giant cells in the mesenchymal chondrosarcomatous component.

  19. [Fibrous displasia of the temporal bone. Presentation of one case].

    Science.gov (United States)

    Márquez Moyano, J A; Ostos Aumente, P; Sánchez Gutiérrez, R; Roldán Nogueras, J; López Villarejo, P

    2005-01-01

    We present one case of a 14 years old girl, diagnosed of fibrous displasia of the temporal bone, who developed a conductive hearing loss of progressive character. We analyse the clinic manifestations, radiologic and histopathologic study, and therapeutic indications of this disease. PMID:16156368

  20. HDPE/COC blends with fibrous morphology and their properties.

    Czech Academy of Sciences Publication Activity Database

    Vacková, Ta?ana; Šlouf, Miroslav; Nevoralová, Martina; Kaprálková, Ludmila

    2012-01-01

    Ro?. 48, ?. 12 (2012), s. 2031-2039. ISSN 0014-3057 R&D Projects: GA ?R GP106/09/P272 Institutional research plan: CEZ:AV0Z40500505 Keywords : polymer blend * phase morphology * fibrous structure Subject RIV: JI - Composite Materials Impact factor: 2.562, year: 2012

  1. Fatty metamorphosis and other patterns in fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Komorowski Richard A

    2003-08-01

    Full Text Available Abstract Background Interpretation of small biopsy fragments from suspected lesions of fibrous dysplasia with unusual clinical and / or radiological features may be challenging due to wide histomorphological spectrum of stromal appearances. Awareness of these variations should improve diagnostic confidence. Methods We retrospectively studied 26 cases of fibrous dysplasia (F- 19, M- 7; Ages ranged from 10 to 53 years with confirmed diagnosis. The sites of the lesions were skull bones (9, humerus (1, femur (8, tibia (2, fibula (3, talus (1, mandible (1, and maxilla (1. Results Different stromal patterns, variably admixed with the classical pattern, were observed in 58%(15/26 of the cases. 20%(3/15 of these had more than one pattern. Focal fatty metamorphosis as groups of fat cells in the central portion of the lesion in the stroma of fibrous dysplasia between osseous trabeculae was observed in 23%(6/26 cases. Other patterns included myxoid stroma in 16%(4/26, collagenization of stroma in 12%(3/26, stroma rich pattern (with paucity of trabeculae in 12%(3/26, foci of few foam cells in 23% (6/26, and calcified spherules in 12%(3/26. Focal osteoblastic rimming of trabeculae was observed only in 4%(1/26. Conclusions Various stromal variations and previously unreported fatty metamorphosis were frequently observed in fibrous dysplasia.

  2. A 40-year-old gossypiboma (foreign body granuloma) mimicking a malignant femoral surface tumor

    Energy Technology Data Exchange (ETDEWEB)

    Sakayama, Kenshi; Fujibuchi, Taketsugu; Kidani, Teruki; Miyawaki, Joji; Yamamoto, Haruyasu [Ehime University School of Medicine, Department of Orthopaedic Surgery, Ehime (Japan); Sugawara, Yoshifumi [Ehime University School of Medicine, Department of Radiology, Ehime (Japan)

    2005-04-01

    The patient was a 61-year-old man who developed gossypiboma of the left thigh and femur resulting in the imaging appearances of a malignant surface tumor. He had a past history of surgery on the left femur for open fracture 40 years previously. Radiographs and CT showed a soft tissue mass with osteolysis and periosteal thickening of the left femur. On MRI, the mass showed heterogeneous signal intensity with contrast enhancement at the periphery, suggesting a malignancy. {sup 99m}Tc-HMDP bone scintigraphy showed a faint ring-like uptake, but thallium -201 scintigraphy did not show any uptake in the tumor. An extensive intralesional excision was performed. Postoperative histopathological examination showed a fibrous foreign body with reactive changes. There were neither viable cells nor atypical giant cells around the foreign body. No malignant change was evident. Based on surgical and histopathological examinations, the tumor was finally diagnosed as gossypiboma related to a retained surgical sponge. (orig.)

  3. Primary malignant intramedullary lymphoma

    International Nuclear Information System (INIS)

    A case of primary malignant intramedullary lymphoma, localized in the dorsal part of the spinal cord is presented. The clinical symptoms were associated with motor and sensitive deficit. Clinical investigations excluded the presence of lymphoma in other locations in the central nervous system and the extra neural organs. Postoperative radiotherapy and chemotherapy improved relict neurological symptoms. (authors)

  4. Aggressive malignant phyllodes tumor

    Directory of Open Access Journals (Sweden)

    Nathan Roberts

    2015-01-01

    Conclusion: Despite biopsy proven malignant phyllodes tumor, it was near impossible to predict such a rapid course of disease progression in our patient. Our case illustrates the unpredictable nature of this disease in general and it possibly sheds light on a variant of the disease which had undergone an aggressive transformation.

  5. Direct Numerical Simulation of Liquid Transport Through Fibrous Porous Media

    Science.gov (United States)

    Palakurthi, Nikhil Kumar

    Fluid flow through fibrous media occurs in many industrial processes, including, but not limited, to fuel cell technology, drug delivery patches, sanitary products, textile reinforcement, filtration, heat exchangers, and performance fabrics. Understanding the physical processes involved in fluid flow through fibrous media is essential for their characterization as well as for the optimization and development of new products. Macroscopic porous-media equations require constitutive relations, which account for the physical processes occurring at the micro-scale, to predict liquid transport at the macro-scale. In this study, micro-scale simulations were conducted using conventional computational fluid dynamics (CFD) technique (finite-volume method) to determine the macroscopic constitutive relations. The first part of this thesis deals with the single-phase flow in fibrous media, following which multi-phase flow through fibrous media was studied. Darcy permeability is an important parameter that characterizes creeping flow through a fibrous porous medium. It has a complex dependence on the medium's properties such as fibers' in-plane and through-plane orientation, diameter, aspect ratio, curvature, and porosity. A suite of 3D virtual fibrous structures with a wide range of geometric properties were constructed, and the permeability values of the structures were calculated by solving the 3D incompressible Navier-Stokes equations. The through-plane permeability was found to be a function of only the fiber diameter, the fibers' through-plane orientation, and the porosity of the medium. The numerical results were used to extend a permeability-porosity relation, developed in literature for 3D isotropic fibrous media, to a wide range of fibers' through-plane orientations. In applications where rate of capillary penetration is important, characterization of porous media usually involves determination of either the effective pore radius from capillary penetration experiments or a representative pore radius (R50) from pore-size distribution data. The relationship between effective and representative pore radii was studied by performing direct simulations of capillary penetration of a wetting liquid using a finite-volume-based volume-of-fluid (VOF) method. The simulated unidirectional liquid penetration through fibrous media followed Lucas-Washburn kinetics (L ˜ t1/2), except during the initial stages, which are dominated by inertial forces. Even though fluid properties and contact angle were kept constant in the simulations, the effective pore radii were found to be quite different from the representative radii. It can be concluded that the differences between effective and representative pore radii did not arise from contact angle variations. The unsaturated flow through fibrous media at the macro-scale is typically described using Richard's equation which requires constitutive relations: capillary pressure and permeability as a function of liquid saturation. In the present study, the quasi-static capillary pressure-saturation (P c-S) relationship for the primary drainage in a 3D isotropic fibrous medium was determined by performing micro-scale simulations using a VOF method. The Pc-S relationship obtained from the VOF method was compared with the results from the full-morphology (FM) method. Good agreement was observed between the results from the VOF and FM methods, thus suggesting that the FM method, a computationally less intensive method as compared to VOF method, may be sufficient for estimating the Pc-S relationship for primary drainage.

  6. Image diagnosis of malignant mesothelioma

    International Nuclear Information System (INIS)

    3 cases of malignant mesothelioma confirmed by pathological examination were reported. CT showed solid mass with moderate enhancement by contrast medium. CT appears to be a very useful tool to make a diagnosis of malignant mesothelioma. (author)

  7. Radiation associated malignant pleural mesothelioma

    International Nuclear Information System (INIS)

    Malignant pleural mesothelioma of epithelial type developed in a 24 year old woman, 20 years after radiotherapy for Hodgkin's disease. This case and a review of published cases indicate that radiation may induce malignant mesothelioma. (author)

  8. Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues

    Directory of Open Access Journals (Sweden)

    Steinau Hans-Ulrich

    2006-07-01

    Full Text Available Abstract Background Solitary fibrous tumors (SFT represent a rare entity of soft tissue tumors. Previously considered being of serosal origin and solely limited to the pleural cavity the tumor has been described in other locations, most particularly the head and neck. Extrathoracic SFT in the soft tissues of the trunk and the extremities are very rare. Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and treatment results. Methods Data were obtained from patients' records, phone calls to the patients' general practitioners, and clinical follow-up examination, including chest X-ray, abdominal ultrasound, and MRI or computed tomography. Results There were 6 females and 3 males, whose age at time of diagnosis ranged from 32 to 92 years (mean: 62.2 years. The documented tumors' size was 4.5 to 10 cm (mean: 7 cm. All tumors were located in deep soft tissues, 3 of them epifascial, 2 subfascial, 4 intramuscular. Four tumors were found at the extremities, one each at the flank, in the neck, at the shoulder, in the gluteal region, and in the deep groin. Two out of 9 cases were diagnosed as atypical or malignant variant of ESFT. Complete resection was performed in all cases. Follow-up time ranged from 1 to 71 months. One of the above.mentioned patients with atypical ESFT suffered from local relapse and metastatic disease; the remaining 8 patients were free of disease. Conclusion ESFT usually behave as benign soft tissue tumors, although malignant variants with more aggressive local behaviour (local relapse and metastasis may occur. The risk of local recurrence and metastasis correlates to tumor size and histological status of surgical resection margins and may reach up to 10% even in so-called "benign" tumors. Tumor specimens should be evaluated by experienced soft tissue pathologists. The treatment of choice is complete resection followed by extended follow-up surveillance.

  9. Fibrous dysplasia mimicking bone metastasis on both bone scintigraphy and 18F FDG PET CT: Diagnostic dilemma in a patient with breast cancer

    International Nuclear Information System (INIS)

    Bone is the most common distant site to which breast cancer metastasizes. Commonly used imaging modalities for imaging bone metastasis are bone scintigraphy, plain radiography, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Although bone scintigraphy gas high sensitivity for detecting bone metastasis, its specificity is low. This is because of the fact that bone scintigraphy images secondary changes in bone rather than just tumor cells 18F fluorodeoxyglucose (18F FDG) PET CT, on the other hand, directly images the tumor cells' glucose metabolism. Unfortunately, similar to bone scintigraphy, benign bone conditions can also show increased 18F FDG uptake on PET CT, and PET positive asymptomatic fibrous dysplasia can be misinterpreted as a metastasis. Fibrous dysplasia of bone has wide skeletal distribution, with variability of 18F FDG uptake and CT appearance. It is therefore important to recognize the characteristics of this skeletal dysplasia, to allow differentiation from skeletal metastasis. Bone lesions with 18F FDG uptake need to be carefully interpreted when evaluating patients with known malignancy. In doubtful cases, fibrous dysplasia should be given as a differential diagnosis and histopathological diagnosis may be warranted, as highlighted in the present case

  10. Fibrous dysplasia mimicking bone metastasis on both bone scintigraphy and {sup 18}F FDG PET CT: Diagnostic dilemma in a patient with breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    KC, Sud Hir Suman; Sharma, Punit; Singh, Har Man Deep; Bal, Chand Rasekhar; Kumar, Rake Sh [India Institute of Medical Sciences, New Delhi (India)

    2012-12-15

    Bone is the most common distant site to which breast cancer metastasizes. Commonly used imaging modalities for imaging bone metastasis are bone scintigraphy, plain radiography, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Although bone scintigraphy gas high sensitivity for detecting bone metastasis, its specificity is low. This is because of the fact that bone scintigraphy images secondary changes in bone rather than just tumor cells {sup 18}F fluorodeoxyglucose ({sup 18}F FDG) PET CT, on the other hand, directly images the tumor cells' glucose metabolism. Unfortunately, similar to bone scintigraphy, benign bone conditions can also show increased {sup 18}F FDG uptake on PET CT, and PET positive asymptomatic fibrous dysplasia can be misinterpreted as a metastasis. Fibrous dysplasia of bone has wide skeletal distribution, with variability of {sup 18}F FDG uptake and CT appearance. It is therefore important to recognize the characteristics of this skeletal dysplasia, to allow differentiation from skeletal metastasis. Bone lesions with {sup 18}F FDG uptake need to be carefully interpreted when evaluating patients with known malignancy. In doubtful cases, fibrous dysplasia should be given as a differential diagnosis and histopathological diagnosis may be warranted, as highlighted in the present case.

  11. Diffuse malignant pleural mesothelioma in an urban hospital: Clinical spectrum and trend in incidence over time

    International Nuclear Information System (INIS)

    This retrospective analysis reviews the clinical experience of a major urban referral hospital with diffuse malignant pleural mesothelioma during the 14-year period from 1973 through 1986. Seventy-five cases of definite or equivocal mesothelioma were identified. There were four cases of primary malignant peritoneal mesothelioma, seven cases of benign fibrous mesothelioma, and 64 cases of diffuse malignant pleural mesothelioma. In 43 cases (67%) of diffuse malignant pleural mesothelioma, there was historic evidence of asbestos exposure. In 21 cases (33%), there was no known history of asbestos exposure. An increase in annual incidence of diffuse malignant pleural mesothelioma was observed over the study period, from three cases in 1973 to ten cases in 1986. Despite greater awareness of this disease, the diagnosis remains a difficult one to establish given the nonspecific symptoms, signs and radiographic appearance, variable histologic appearance, and poor diagnostic sensitivity and specificity of thoracentesis and closed pleural biopsy. Thoracotomy, thoracoscopy, and CT-guided needle biopsies gave higher yields and are the diagnostic measures of choice when diffuse malignant pleural mesothelioma is suspected

  12. Primary malignant pericardial mesothelioma.

    Science.gov (United States)

    Turk, J; Kenda, M; Kranjec, I

    1991-09-16

    Malignant primary tumors of the pericardium are rare. The authors present two male patients, aged 44 and 67 years, not exposed to asbestos, who died from pericardial mesothelioma. Repeated evacuation of fluid from the pericardium due to cardiac tamponade failed to reveal the cause of pericarditis. In one case, the diagnosis was made on surgical exploration, and in the other, at autopsy. A significant difference between benign and malignant pericardial effusion was observed. In cases of pericardial mesothelioma, symptoms of epicardial involvement cannot be attributed solely to the hindered inflow and cardiac tamponade, but also to congestive heart failure due to myocardial infiltration. In one patient, temporary improvement was achieved, first by pronisone therapy and then by radiotherapy. PMID:1749207

  13. Transarticular invasion of the sacroiliac joints by malignant pelvic bone tumors

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hwang Woo; Huh, Jin Do; Kim, Seong Min; Cho, Young Duk [College of Medicine, Kosin Univ., Pusan (Korea, Republic of); Cho, Kil Ho [College of Medicine, Yeungnam Univ., Daegu (Korea, Republic of)

    2002-03-01

    To describe modes of transarticular invasion, with reference to the size and location of a tumor, the anatomic characteristics of invaded cartilage,and the existence of ankylosis in SI joint. Eleven histologically confirmed malignant pelvic bone tumors involving transarticular invasion of sacroiliac joints, were retrospectively analysed. Transarticular invasion of a joint was defined as involvement of its opposing bones. The anatomic site and size of the tumors were analysed, and invaded sacroiliac joint was divided into upper, middle and lower parts on the basis of the anatomic characteristics of the intervening cartilage: synovial hyaline or fibrous ligamentous. the existence of ankylosis was determined, and transarticular invasion directly across a joint was classified as direct invasion. Extension of tumors around a joint from its periphery to the opposing bone were considered as indirect invasion. All tumors were located near the sacroiliac joint, eight at the ilium and three at the sacrum. Six invasions were indirect and five were direct. Average tumor area was larger in indirect cases than in direct: 191.8 cm{sup 2} vs. 69.6 cm{sup 2}. In all indirect invasions, a huge soft tissue mass abutted onto the peripheral portion of the sacroiliac joint. In five of six cases of indirect transarticular invasion, the upper part of the joint posteriorly located fibrous ligamentous cartilage. In the other, the lower part was invaded, and this involved a detour around the joint space, avoiding the invasion of intervening cartilage. Ankylosis occurred in one of the indirect cases. Among the five cases of direct invasion, there was invasion of the posteriorly located ligamentous fibrous cartilage in three without ankylosis. In the other two cases, involving ankylosis, the synovial hyaline cartilage was invaded directly at the lower part of the joint. Transarticular invasions of sacroiliac joint via fibrous cartilage are most common. Ankylosis of the sacroiliac joint facilitates hyaline cartilage invasion. We consider that in transarticular invasion of malignant pelvic bone tumors, indirect invasion is more common than direct.

  14. Ceruloplasmin in human malignancies.

    OpenAIRE

    Chakraborty,Prabir Kishore; Ghosh,Aparesh; Chowdhury,J Roy

    1984-01-01

    The ceruloplasmin concentration was determined in 145 cancer patients prior to and after treatment with different radiotherapeutic and chemotherapeutic regimes. The ceruloplasmin concentration was observed to be higher in patients with malignancies than in healthy controls. There was a positive correlation of the values with the clinical condition of the patients. The ceruloplasmin concentration was noted to stop increasing and subsequently fall in patients who responded to therapy, and, in c...

  15. Primary pineal malignant melanoma

    OpenAIRE

    Cesar La Cruz Pelea; Oderay Mabel Cedeño Díaz; Roberto Garcia Leal

    2011-01-01

    Primary pineal malignant melanoma is a rare entity, with only thirteen cases reported in the world literature to date. We report a case of a 70-year-old man, who consulted with gait disturbance of six months duration, associated in the last month with dizziness, visual abnormalities and diplopia. No other additional melanocytic lesions were found elsewhere. The magnetic resonance showed a 25 mm expansive mass in the pineal gland that was associated with hydrocephaly, ventricular and transepen...

  16. Detection of ocular malignancies.

    OpenAIRE

    Lyons, C. J.; HUNGERFORD, J.

    1990-01-01

    The case notes of new patients attending the oncology clinic at Moorfields Eye Hospital during the first 5 months of 1988 were analysed retrospectively with regard to the origin of the primary referral, the presence of symptoms, the diagnosis and management. Sixty-eight of 94 new patients were diagnosed as having malignant ocular lesions. Of these 68, 47% were first seen and referred by an optician. Half of these patients were asymptomatic at the time of detection.

  17. Microbiome and Malignancy

    OpenAIRE

    Plottel, Claudia S.; Blaser, Martin J.

    2011-01-01

    Current knowledge is insufficient to explain why only a proportion of individuals exposed to environmental carcinogens or carrying a genetic predisposition to cancer develop disease. Clearly, other factors must be important and one such element that has recently received attention is the human microbiome, the residential microbes including Bacteria, Archaea, Eukaryotes, and viruses that colonize humans. Here, we review principles and paradigms of microbiome-related malignancy, as illustrated ...

  18. Meningioma maligno / Malignant meningioma

    Scientific Electronic Library Online (English)

    Yvei, González Orlandi; Luis, Elizondo Barrier; Reinel, Junco Martín; Jorge, Rojas Manresa; Víctor, Duboy Limonta; Alberto, Pérez Villafuerte.

    2011-03-01

    Full Text Available Los meningiomas intracraneales son tumores por lo general benignos, de crecimiento lento, y se originan en la capa de células aracnoideas, especialmente en las granulaciones aracnoideas. Los meningiomas anaplásicos o malignos representen solo el 1-3 %. En ocasiones simulan lesiones tumorales neuroep [...] iteliales malignas, por su crecimiento rápido y la frecuente invasión al tejido cerebral vecino; suelen recidivar con mayor frecuencia y muchas veces requieren terapia coadyuvante. Las imágenes topográficas de este tipo de tumores suelen ser hiperdensas, con muy buena captación del contraste, regulares y bien delimitadas con poco o ningún edema asociado, todo lo contrario a lo visto en el caso que se presenta, en el cual las imágenes parecían corresponder a las de un glioma maligno (glioblastoma multiforme). Abstract in english The intracranial meningiomas are tumors in general of benign type of a slow growth originating in the arachnoid cells layer, especially in arachnoid granulations. The anaplastic or malignant meningiomas accounted for only the 1-3%. Sometimes they simulate malignant neuroepithelial lesions due to its [...] fast growth and the frequent invasion of surrounding cerebral tissue with very frequent relapses and many times they required adjuvant therapy. The topographic images of this type of tumor are hyper-denses with a good contrast capture, regular and well defined with not much or not associated edema, quite the contrary that observed in present case where images seems to correspond with those of a malignant glioma (multiforme glioblastoma).

  19. Meningioma maligno Malignant meningioma

    Directory of Open Access Journals (Sweden)

    Yvei González Orlandi

    2011-03-01

    Full Text Available Los meningiomas intracraneales son tumores por lo general benignos, de crecimiento lento, y se originan en la capa de células aracnoideas, especialmente en las granulaciones aracnoideas. Los meningiomas anaplásicos o malignos representen solo el 1-3 %. En ocasiones simulan lesiones tumorales neuroepiteliales malignas, por su crecimiento rápido y la frecuente invasión al tejido cerebral vecino; suelen recidivar con mayor frecuencia y muchas veces requieren terapia coadyuvante. Las imágenes topográficas de este tipo de tumores suelen ser hiperdensas, con muy buena captación del contraste, regulares y bien delimitadas con poco o ningún edema asociado, todo lo contrario a lo visto en el caso que se presenta, en el cual las imágenes parecían corresponder a las de un glioma maligno (glioblastoma multiforme.The intracranial meningiomas are tumors in general of benign type of a slow growth originating in the arachnoid cells layer, especially in arachnoid granulations. The anaplastic or malignant meningiomas accounted for only the 1-3%. Sometimes they simulate malignant neuroepithelial lesions due to its fast growth and the frequent invasion of surrounding cerebral tissue with very frequent relapses and many times they required adjuvant therapy. The topographic images of this type of tumor are hyper-denses with a good contrast capture, regular and well defined with not much or not associated edema, quite the contrary that observed in present case where images seems to correspond with those of a malignant glioma (multiforme glioblastoma.

  20. Malignant biliary obstruction

    International Nuclear Information System (INIS)

    This paper assesses the value of CT in predicting surgical resectability of tumors in patients with malignant biliary obstruction. A retrospective analysis was performed on 320 consecutive patients with malignant biliary obstruction over a 3-1/2-year period. Most patients were treated nonoperatively. Fifty-one patients fulfilled the selection criteria of surgical exploration, pathological confirmation of malignancy, and prepoperative CT scans available for review. The CT scans were reviewed by a blinded reader and assessed for surgical resectability of tumors. There were 32 patients with pancreatic adenocarcinoma, 6 with ampullary carcinoma, 5 with cholangiocarcinoma, 2 with gallbladder carcinoma, and 6 with other pathologic diagnoses. Of 36 patients thought to have unresectable tumors based on CT findings, 32 were found to have surgically unresectable tumors (positive predictive value, 89%). Of 15 patients thought to have resectable tumors based on CT findings, 11 had surgically resectable tumors (positive predictive value, 73%). CT missed positive duodenal lymph nodes in 2 patients, portal vein infiltration in 1 patient, and small liver metastases in 1 patient

  1. Development of flame resistant treatment for Nomex fibrous structures

    Science.gov (United States)

    Toy, M. S.

    1977-01-01

    Flame resistant fibrous materials for space shuttle application were developed through chemical modification of commercially available aromatic polyamide fibrous products. The new surface treatment was achieved in the laboratory by ultraviolet activation of the fabric in the presence of fluoroolefin monomers and a diluent gas. The monomers grafted under these conditions provide the improved properties of the fabric in flame resistance, chemical inertness, and nonwettability without the sacrifice of color or physical properties. The laboratory reaction vessel was scaled-up to a batch continuous process, which treats ten yards of the commercial width textiles. The treated commercial width Nomex (HT-10-41) from the scaled-up reactor is self-extinguishing in an oxygen-enriched environment, water-repellent, soft, silky, and improved in chemical resistance. Unlike most textile processes, the grafting unit operates under dry conditions and no chemical by-products have to be washed out of the finished product.

  2. Fibrous dysplasia as a rare cause of nasolacrimal duct obstruction

    Directory of Open Access Journals (Sweden)

    Bahtiyar Polat

    2015-09-01

    Full Text Available Fibrous dysplasia of the paranasal sinuses is mostly asymptomatic, but sometimes may cause signs and symptoms de- pending on its location. We report two cases of maxillary fibrous dysplasia obstructing the lacrimal drainage system as a reason of chronic dacryocystitis, and reviewed the related literature. The first case underwent an endonasal endoscopic approach combined with external dacryocystorhinostomy. He had a patent lacrimal system at one-year follow-up. The le- sion was completely removed via an endonasal endoscopic approach in the second case, wherein the patient was asymp- tomatic of the six-month follow-up period. [Arch Clin Exp Surg 2015; 4(3.000: 172-175

  3. Interaction of ruby laser with carbon fibrous materials

    Directory of Open Access Journals (Sweden)

    Staši? Jelena M.

    2007-01-01

    Full Text Available Carbon fibrous materials are interesting because of their good properties and numerous possible applications. The characteristics of these materials can be programmed by careful selection of the modification process parameters. The laser technique can be successfully employed for these purposes. The high temperatures arising in the material during a short laser pulse can cause a number of changes in the material. Carbon fibrous materials with different textile shapes, during different stages of processing, were exposed to laser radiation. A ruby laser (X=694.3 nm was used to modify the material. The structural changes were examined by scanning electron microscopy and X-ray diffraction. It was established that the radiation of this laser induces structural changes leading to a better arrangement of the turbostratic carbon fiber structure.

  4. Electrospun Fibrous Membranes with Super-large-strain Electric Superhydrophobicity

    Science.gov (United States)

    Zhou, Hua; Wang, Hongxia; Niu, Haitao; Lin, Tong

    2015-10-01

    Large-strain elastic superhydrophobicity is highly desirable for its enhanced use performance and functional reliability in mechanically dynamic environments, but remains challenging to develop. Here we have, for the first time, proven that an elastic fibrous membrane after surface hydrophobization can maintain superhydrophobicity during one-directional (uniaxial) stretching to a strain as high as 1500% and two-direction (biaxial) stretching to a strain up to 700%. The fibrous membrane can withstand at least 1,000 cycles of repeated stretching without losing the superhydrophobicity. Stretching slightly increases the membrane air permeability and reduces water breakthrough pressure. It is highly stable in acid and base environments. Such a permeable, highly-elastic superhydrophobic membrane may open up novel applications in membrane separation, healthcare, functional textile and energy fields.

  5. Transition metal complexing with polymetric sulfur-containing fibrous ligand

    International Nuclear Information System (INIS)

    A study was made on interaction of Cr4, V5, Cu2 transition metals with thioamidated polymeric PVS-PAN-T ligand of fibrous structure. Sorption characteristics of PVS-PAN-T, depending on pH and temperature of solutions of copper, chromium and vanadium salts were determined. Parameters of ESR spectra of PVS-PAN-T compounds with transition metals enabled to determine the structure of formed coordination centers

  6. Engineering of Fibrous Scaffolds for use in Regenerative Medicine

    OpenAIRE

    George, Julian H.S.

    2009-01-01

    Tissue engineering with fibrous scaffolds is emerging as a major research area in the field of regenerative medicine. The major themes pursued in this thesis are the study of the cellular response to nanofibrous constructs, the role of nanofibres in the engineering of synthetic scaffolds, and the development of technology to facilitate the fabrication of nanofibrous scaffolds with controlled architectures. Cells cultured on multi?walled carbon nanotubes displayed reduced prolif...

  7. Determination of physical properties of fibrous thermal insulation

    OpenAIRE

    Jeandel G.; Monod B.; Lassue S.; Joulin A.; Tilioua A.; Libessart L.

    2012-01-01

    The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET) with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool) are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a de...

  8. A Micromechanics Finite-Strain Constitutive Model of Fibrous Tissue

    OpenAIRE

    Chen, Huan; LIU Yi; Zhao, Xuefeng; Lanir, Yoram; Kassab, Ghassan S.

    2011-01-01

    Biological tissues have unique mechanical properties due to the wavy fibrous collagen and elastin microstructure. In inflation, a vessel easily distends under low pressure but becomes stiffer when the fibers are straightened to take up the load. The current microstructural models of blood vessels assume affine deformation; i.e., the deformation of each fiber is assumed to be identical to the macroscopic deformation of the tissue. This uniform-field (UF) assumption leads to the macroscopic (or...

  9. Directionally oriented fibrous structures for llghtweight concrete elements reinforcement

    OpenAIRE

    Fangueiro, Raúl; Marques, P.; Pereira, C. Gonilho

    2010-01-01

    This paper reports on the work that is being undertaken at the University of Minho concerning the development of directionally oriented fibrous structures (DOFS) to be used as a concrete reinforcement material. Several glass fibre wovenlike DOFS were produced varying two parameters: roving linear density (tex) and reinforcement structural density (rovings/ cm). Self-compacting concrete slabs were reinforced by DOFS structures and their bending behaviour was evaluated. The resul...

  10. Characterization of the thermal conductivity for fibrous refractory composite insulations

    Science.gov (United States)

    Stewart, D. A.; Leiser, D. B.

    1985-01-01

    Thermal conductivity for a family of fibrous, refractory composite insulations are characterized through the use of an engineering model and arc-jet data. The model defines the composite as a uniform pore material using measured physical and mechanical properties. Efficiency parameters assigned to the solid and radiation conduction terms in the thermal conductivity equation were found to be dependent only on solid volume fraction and porosity.

  11. Intramuscular solitary fibrous tumor: a clinicopathological case study.

    Science.gov (United States)

    Abe, S; Imamura, T; Tateishi, A; Park, P; Nakano, H; Harasawa, A; Hashimoto, H; Matsushita, T

    1999-01-01

    We present a case of extrapleural solitary fibrous tumor arising within the muscle, an unusual and hitherto-undescribed tumor lesion. A 42-year-old woman presented a painless mass in her left thigh. The lesion was depicted as an intramuscular mass that enhanced on both CT and MRI, showing quite rich tumor vascularity. The histological features of the tumor were spindle cell proliferation with various histological patterns, typical fibrocollagenous background, and positive immunoreactivity for CD-34. PMID:10348456

  12. Ibrutinib for B cell malignancies

    OpenAIRE

    Novero, Aileen; Ravella, Pavan M; Chen, Yamei; Dous, George; Liu, Delong

    2014-01-01

    Research over the role of Bruton’s agammaglobulinemia tyrosine kinase (BTK) in B-lymphocyte development, differentiation, signaling and survival has led to better understanding of the pathogenesis of B-cell malignancies. Down-regulation of BTK activity is an attractive novel strategy for treating patients with B-cell malignancies. Ibrutinib (PCI-32765), a potent inhibitor of BTK induces impressive responses in B-cell malignancies through irreversible bond with cysteine-481 in the active site ...

  13. A Rare Malignant Triton Tumor

    OpenAIRE

    Tripathy, Kalpalata; Mallik, Rabinarayan; Mishra, Aparajita; Misra, Debiprasad; Rout, Niranjan; Nayak, Padmalaya; Samantray, Sagarika; Rath, Jayshree

    2010-01-01

    Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation, malignant triton tumor, has a rare incidence. We report such a case in a 40-year-old male who presented with a mass over the buttock. He was a previously diagnosed case of neurofibroma in the same area. Histomorphology supported by immunostaining with S-100 protein confirmed the diagnosis. Malignant triton tumor has a poor prognosis owing to its aggressive biological behavior. The fact that the presence of this tum...

  14. Recent Advances on Fractal Modeling of Permeability for Fibrous Porous Media

    Science.gov (United States)

    Cai, Jianchao; Luo, Liang; Ye, Ran; Zeng, Xiangfeng; Hu, Xiangyun

    2015-03-01

    Permeability is an important hydraulic parameter for characterizing heat and mass transfer properties of fibrous porous media. However, it is difficult to be quantitatively predicted due to the complex and irregular pore structure of fibrous porous media. Fractal geometry has been verified to be an effective method for determining the permeability of fibrous porous media. In this study, recent works on the permeability of fibrous porous media by means of fractal geometry are reviewed, the advances for each presented fractal model are analyzed and summarized, parameter equations used in available fractal permeability models are also briefly compared and reviewed. Future work for more generalized permeability model of fibrous porous media need to conducted by considering the special characters of fibrous materials, uniform pore structure parameter model and the influence factor of capillary pressure, electrokinetic phenomena, etc.

  15. Radiotherapy of malignant melanoma

    International Nuclear Information System (INIS)

    The role of radiotherapy in the treatment of malignant melanoma is limited, and surgery generally forms the mainstay of medical practice. However, there are some circumstances in which radiotherapy should be considered the treatment of choice. Symptomatic metastatic lesions in bone or brain can effectively be palliated in a substantial proportion of instances. At the current stage of our knowledge, conventionally fractionated treatment of such lesions forms the standard against which other treatments should be measured. In contrast, metastatic lesions to skin or lymph nodes that do not overlie critical normal structures probably are better treated by high-dose-per-fraction techniques. Radiotherapy may play a definitive role in the treatment of lentigo maligna. The precise optimal energy of the beam to be used remains to be defined. Slightly more penetrating radiation appears to be required for lentigo maligna melanomas. Here, too, the optimal energy remains to be defined. The treatment of nonlentigenous melanomas primarily by radiotherapy is unproved in my opinion. Certainly, the data from the Princess Margaret Hospital is exciting, but I believe it must be corroborated by a well-designed trial before it can be accepted without question. Future directions in treatment of malignant melanoma are likely to include further trials of unconventional fractionation and the use of radiosensitizing agents in conjunction with radiotherapy. The time for dermatologists and radiation therapists to cooperate in such studies is at hand

  16. Optimization of Grafted Fibrous Polymer as a Solid Basic Catalyst for Biodiesel Fuel Production

    OpenAIRE

    Yuji Ueki; Seiichi Saiki; Takuya Shibata; Hiroyuki Hoshina; Noboru Kasai; Noriaki Seko

    2014-01-01

    Grafted fibrous polymer with quaternary amine groups could function as a highly-efficient catalyst for biodiesel fuel (BDF) production. In this study, the optimization of grafted fibrous polymer (catalyst) and transesterification conditions for the effective BDF production was attempted through a batch-wise transesterification of triglyceride (TG) with ethanol (EtOH) in the presence of a cosolvent. Trimethylamine was the optimal quaternary amine group for the grafted fibrous catalyst. The opt...

  17. MR imaging of endometrial benign and malignant polypoid lesions: correlations with clinicopathological findings

    International Nuclear Information System (INIS)

    Objective: To investigate the diagnostic value of conventional and dynamic gadolinium- enhanced T1-weighted (T1W) MRI in benign and malignant endometrial polypoid lesions. The pathologic basis of MRI features was also evaluated. Methods: The conventional and dynamic contrast enhanced MRI features in 48 cases with clinicopathologically-proved endometrial polypoid lesions were retrospectively analyzed, including 26 cases with malignant tumors (23 cases with endometrial carcinoma and 3 cases with endometrial sarcoma) and 22 cases with benign polypoid lesions (12 cases with endothelial polyps and 10 cases with submucous leiomyomas). The occurrence probability of central fibrous core, intratumoral cysts and intact junctional zone were evaluated by Fisher's exact test. Results: Benign and malignant endometrial polypoid lesions had specific characteristics on MRI. Endometrial carcinomas usually appeared as homogeneous intermediate or slighfiy high signal-intensity masses on T2-weighted images, and relatively homogeneous hypodense masses on contrast-enhanced images with myometrial invasion (P 2WI and demonstrated areas of early and persistent marked enhancement. Submueous leiomyomas demonstrated isodense or slightly low-density masses with defined outline on T2WI and the endomerium was displaced. The diagnostic sensitivity, specificity and accuracy of malignant polypoid masses were 92.3% (24/26), 83.3% (20/24) and 95.8% (46/48) respectively. Conclusion: Conventional and dynamic contrast-enhanced MRI are valuable in characterizing the benign and malignant endometrial polypoid lesions. (authors)

  18. Displasia fibrosa de seno maxilar / Fibrous Dysplasia of Maxillary Sinus

    Scientific Electronic Library Online (English)

    Cecilia, Parladé Formell; Yamily, González Cardona; Portelles Massó, Ayelén M; Julio O, Fuentes de la Rosa; Mirian, Vivar Bauzá.

    2015-03-01

    Full Text Available La displasia fibrosa fue descrita por Lichtenstein en 1938, es una enfermedad caracterizada por el reemplazo progresivo de tejido óseo normal por una proliferación de tejido conectivo fibroso, por su forma de presentación se clasifica en monostótica o poliostótica. La forma monostótica, localizada e [...] n la región craneofacial constituye solo el 10 % de los casos, se presenta con mayor frecuencia en el maxilar superior y puede afectar a huesos adyacentes como el cigomático, esfenoides y occipital. La degeneración sarcomatosa puede ocurrir en un 0,5 %. Se presenta el caso de una paciente femenina, de 37 años de edad, operada ocho años antes de displasia fibrosa en el Servicio de Cirugía Máxilofacial del Hospital Vladimir I. Lenin, que luego de su embarazo y parto presenta un aumento de volumen en área malar y maxilar izquierdos, a la que se le realiza biopsia que da como resultado una recidiva. Se le realiza cirugía remodelativa de pared anterior de seno maxilar, a través de una incisión de Weber-Ferguson, con buenos resultados estéticos y funcionales. Abstract in english Fibrous dysplasia was described by Lichtenstein in 1938, is a progressive disease characterized by replacement of normal bone tissue by proliferation of fibrous connective tissue, its presentation is classified in monostotic or polyostotic. The monostotic form, located in the craniofacial region con [...] stitutes only 10 % of cases, it occurs most frequently in the maxilla and adjacent bones can affect as the zygomatic, sphenoid and occipital. The sarcomatous degeneration can occur in 0.5 %. A 37-year-old female patient, who underwent fibrous dysplasia surgery eight years ago at Maxillofacial Surgery Department of Vladimir I. Lenin Hospital, which after the pregnancy and delivery presented a volume increase in malar and left area is presented in this paper, biopsy is performed whose results showed a recurrence. Remodeling surgery was performed of anterior wall of the maxillary sinus through a Weber-Ferguson incision with good cosmetic and functional results.

  19. Primary pineal malignant melanoma

    Directory of Open Access Journals (Sweden)

    Oderay Mabel Cedeño Díaz

    2011-06-01

    Full Text Available Primary pineal malignant melanoma is a rare entity, with only thirteen cases reported in the world literature to date. We report a case of a 70-year-old man, who consulted with gait disturbance of six months duration, associated in the last month with dizziness, visual abnormalities and diplopia. No other additional melanocytic lesions were found elsewhere. The magnetic resonance showed a 25 mm expansive mass in the pineal gland that was associated with hydrocephaly, ventricular and transependimary oedema. The lesion was partially excised by a supracerebellar infratentorial approach. The histological examination revealed a melanoma. The patient received radiation therapy, but died of disease 16 weeks later. We herein review the literature on this rare tumour and comment on its clinical, radiological and histopathological features and differential diagnosis.

  20. Primary pineal malignant melanoma

    Science.gov (United States)

    Cedeño Diaz, Oderay Mabel; Leal, Roberto García; La Cruz Pelea, Cesar

    2011-01-01

    Primary pineal malignant melanoma is a rare entity, with only thirteen cases reported in the world literature to date. We report a case of a 70-year-old man, who consulted with gait disturbance of six months duration, associated in the last month with dizziness, visual abnormalities and diplopia. No other additional melanocytic lesions were found elsewhere. The magnetic resonance showed a 25 mm expansive mass in the pineal gland that was associated with hydrocephaly, ventricular and transependimary oedema. The lesion was partially excised by a supracerebellar infratentorial approach. The histological examination revealed a melanoma. The patient received radiation therapy, but died of disease 16 weeks later. We herein review the literature on this rare tumour and comment on its clinical, radiological and histopathological features and differential diagnosis. PMID:24765293

  1. Malign retroperitoneal schwannoma

    International Nuclear Information System (INIS)

    The retroperitoneal tumors are infrequent and are classified according to the original tissue. This is a case presentation of a patient presenting with pain in right hypochondrium and a tumor in this zone, weight loss and painful discomfort in the anterolateral face of right thigh. In physical examination we found cutaneousmucous paleness and painless tumor in hypochondrium and right flank. Abdominal ultrasound (US) showed a homogenous mass of 14,11 cm and abdominal computed tomography allows to see a right retroperitoneal tumor rejecting the kidney. Excretory urogram showed a anteromedial rejection of right kidney. An encapsulated tumor with a few peritumoral adherences was removed. By histological study it was possible to confirm a fusiform cells tumor with hyperchromatism and nuclear pleomorphism, numerous mitosis and areas of necrosis and in the diagnosis of malign tumor of the sheath of a peripheral nerve.(author)

  2. Fulminant metastatic malignant melanoma

    Directory of Open Access Journals (Sweden)

    N.M.K. Faheem,

    2012-07-01

    Full Text Available A 50-year-old lady presented with complaints of chest pain and cough for the past one month. Right supraclavicular lymphadenopathy, bilateral pleural effusion were present. Fine needle aspiration cytology (FNAC from the lymph node showed brownish-black pigment laden tumour cells. Review of history subsequently revealed that she had undergone a surgical procedure over the sole of her left foot three years ago of which no records were available. Reexamination of sole of left foot showed a pigmented infiltraling lesion. Pleural biopsy revealed pigmented tumour deposits. The patient was diagnosed to have fulminant metastatic malignant melanoma of left foot with metastasis to cervical lymph nodes and pleura. This case report re-emphasizes the importance of combined approach to ascertain diagnosis early.

  3. Immunoscintigraphy of malignant melanomas

    International Nuclear Information System (INIS)

    This work is part of a multicentric European evaluation of the monoclonal antibody 225.28s targeted against malignant melanoma and its metastases. Twenty-eight patients (12 males, 16 females, mean age: 53 yrs), who had initially been treated by resection of the primary tumour, were included in the study. Twenty-three of the 26 metastases more than 1 cm in diameter were visualized by immunoscintigraphy. The sensitivity of the procedure (88%) is limited however by the small size of the lesions and their depth, as well as by background noise caused by circulating antibodies. Immunoscintigraphy enables non-invasive investigation of the whole body and can detect lesions that other conventional complementary explorations fail to identify

  4. Malignant priapism: a case report.

    LENUS (Irish Health Repository)

    Ellanti, P

    2011-12-01

    Metastatic involvement of the penis is most commonly from a primary malignant genitourinary tumour. It is a rare phenomenon usually reflecting disseminated malignancy associated with a poor prognosis. Metastasis to the penis mimicking priapism is extremely rare, particularly in the absence of disseminated disease.

  5. Supratentorial malignant glioma

    International Nuclear Information System (INIS)

    To analyze treatments of supratentorial malignant gliomas in the megavoltage era, all the histologic specimens were reviewed and glioblastoma multiforme (GBM) was distuished from anaplastic astrocytoma (AA) by the presence of nectosis. Among those who had completed radiotherapy and who had been followed for at least one year, 135 GBM and 43 AA patients were found. The median survival time (MST) after operation was 12 months for GBM and 18 months for AA. The 5-year survival rate was 0.9% for GBM and 18% for AA. The size of radiation field had little influence on survival time; MST was 12 months for those treated with a generous field (2 cm or more margin), and 13 months for those treated to whole brain. Also for AA, whole brain radiation did not prolong survival. Initial relapse of GBM and AA developed within the irradiated volume in 86% of the cases treated with a generous field. Whole brain radiation seemed useless for the treatment of malignant gliomas. Survival time appeared to be dose-dependent; MST was 10, 13, and 16 months for GBM patients who received 45-57, 57-63, and 63-72 Gy, respectively. Extensive surgical resection was associated with a better prognosis in GBM. AA patients 60 years old or older had a poorer prognosis than younger patients, but age was not a significant prognostic factor for GBM. Chemotherapy appeared to prolong survival slightly without improving long-term survival. Currently, an accelerated hyperfractionation regimen is being tested in which 1.5 Gy is given twice a day up to 69 Gy. Preliminarily, this regimen had no acute or late toxicity and yielded a survival rate at least equivalent to the conventional regimen. (author). 37 refs.; 6 figs.; 4 tabs

  6. Thyroidal malignancy and scintigraphy

    International Nuclear Information System (INIS)

    Thyroid hypofunctional ('scintigraphic cool or cold') nodules are detected frequently. Dependent on the clinical situation, on morbidity and on economic aspects it is necessary to select patients for surgery and to avoid unnecessary surgical treatment. Therefore it is necessary to develop appropriate diagnostic algorithm to manage hypofunctional thyroid nodules. The ultrasound guided fine-needle aspiration cytology (FNA) is on the one hand side a useful diagnostic tool, but on the other hand side there exist certain limitations. It is questionable if the nodule is correctly reached. In case of heterogeneous larger mixed nodules or multiple hypofunctional nodules, it is difficult to choose the correct location of punctation. Furthermore a certain number of FNA's is not diagnostic without any result or due to 'follicular neoplasia'. 99mTc-MIBI-sctintigraphy (MIBI) and 18F-FDG-positron-emission-tomography (FDG-PET) are established methods in the follow-up of differentiated thyroid cancer after thyroidectomy with elevated thyroglobulin-levels without adequate 131-Iodine-uptake. Moreover in case of parafollicular medullary thyroid carcinomas after thyroidectomy with elevated calcitonin-concentrations the FDG-PET is a valuable diagnostic method in localizing tumor. However these tracers gain in importance in differentiating malignant from benign preoperative hypofunctional nodules. In conclusion MIBI-scintigraphy should be used routinely to plan the correct guide of FNA. The application of both methods (MIBI and FNA) improves the differentiation of dignity, whereas a negative MIBI-examination and a negative FNA is able to exclude malignancy nearly. In this way the number of unnecessary numbers of surgical treatments can be reduced. FDG-PET is not definitely superior compared to MIBI-scintigraphy. From the cost perspective MIBI is more attractive than FDG-PET. (orig.)

  7. Primary intracranial malignant lymphoma

    International Nuclear Information System (INIS)

    Nine cases of primary intracranial malignant lymphoma, which accounts for 3.3 % of all intracranial tumors seen in the authors' institution, were studied in terms of diagnostic computed tomographic (CT) features, the tumors' histologic appearance, treatment, post-treatment blood immunologic and cerebrospinal fluid (CSF) characteristics, and outcome. The patients were seven males and two females aged 42 to 67 years. Their chief signs and symptoms on admission were intracranial hypertension, focal signs, and disturbance of consciousness. CT, which proved the most useful preoperative diagnostic technique, demonstrated multiple lesions in seven cases and, in all cases, regions of isodensity or slight high density that were enhanced by contrast medium. According to the patterns of enhancement, the tumors were classed as diffuse (three cases) or nodular (six cases). The former is considered typical of malignant lymphoma, whereas the latter type was sometimes indistinguishable from metastatic tumor and meningioma. At surgery, one patient underwent radical tumor excision, two partial removal, and six biopsy only. Histologic examination revealed one tumor to be of the diffuse small cell type, three of the medium cell type, and five of the large cell type (Lymphoma Study Group classification). Of seven tumors in which lymphocytes were examined by peroxidase-antiperoxidase staining, four were of the B cell type. Postoperatively, whole brain irradiation with 29 to 46 Gy was followed by local irradiation with 15 to 50 Gy. If the tumor persisted, one of three chemotherapies was administered. In one case, methotrexate was given intrathecally. Seven patients were divided into two groups: long remission (three) and recurrence (four). These two groups were compared in terms of serum immunoglobulin levels, T and B cell ratios, CSF characteristics, CT features, tumor cell type, and treatment. No clear differences were found. (author)

  8. Helminths and malignancy

    DEFF Research Database (Denmark)

    Vennervald, Birgitte J; Polman, K.

    2009-01-01

    It has been estimated that chronic infections with viruses, bacteria and parasites contribute to 17.8% of the global burden of cancer, although only a relatively small proportion of the infection-related cancers can be attributed to helminth infections. These are important because of the high number of people who are exposed or infected worldwide. Carcinogenesis associated with helminth infections is a complex process, which may involve several different mechanisms, but chronic inflammation is a key feature. Host immune responses and immunopathological processes mediate inflammatory responses and any failure in the control of the immunological components involved in this response can lead to chronic inflammation. This may generate a microenvironment that might be conducive to the initiation and development of cancer. Inflammatory cells generate free radicals and nitrogen species, which can oxidize and damage DNA and lead to genetic instabilities and malignant transformation. Physical damage caused by the parasites, their eggs or secreted products leads to restorative hyperplasia of the damaged tissue. This may promote the propagation of cells, in which genotoxic damage and pre-malignant change has taken place. Three helminth infections have been classified as definitely carcinogenic to humans (group 1 carcinogens), namely Schistosoma haematobium, which is associated with cancer of the urinary bladder and the food-borne liver flukes Clonorchis sinensis and Opisthorchis viverrini associated with cholangiocarcinoma of the liver. Reducing the level of infection and the risk of getting (re)infected will reduce the risk of cancer development later in life. Helminth infections are thus a preventable cause of cancer, emphasizing the need for sustainable helminth control in endemic areas coupled with health education, especially in relation to food-borne liver fluke infections.

  9. BMP-2-loaded silica nanotube fibrous meshes for bone generation

    Science.gov (United States)

    Chen, Song; Shi, Xuetao; Morita, Hiromi; Li, Jie; Ogawa, Nobuhiro; Ikoma, Toshiyuki; Hayakawa, Satoshi; Shirosaki, Yuki; Osaka, Akiyoshi; Hanagata, Nobutaka

    2011-12-01

    Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

  10. Fibrous Dysplasia and Fibroblast Growth Factor-23 Regulation

    OpenAIRE

    Boyce, Alison M; Bhattacharyya, Nisan; Collins, Michael T.

    2013-01-01

    Fibrous dysplasia (FD) is a skeletal disorder caused by activating mutations in Gs? that result in elevations in cAMP. A feature of FD is elevated blood levels of the bone cell-derived phosphaturic hormone, fibroblast growth factor-23 (FGF23). FGF23 regulates serum phosphorus and active vitamin D levels by action on proximal renal tubule cells. An essential step in the production of biologically active FGF23 is glycosylation by the UDP-N-acetyl-?-D-galactosamine:polypeptide N-acetylgalactosam...

  11. The use of fibrous ion exchangers in gold hydrometallurgy

    Science.gov (United States)

    Kautzmann, R. M.; Sampaio, C. H.; Cortina, J. L.; Soldatov, V.; Shunkevich, A.

    2002-10-01

    This article examines a family of ion-exchange fibers, FIBAN, containing primary and secondary amine groups. These ion exchangers have a fiber diameter of 20 40 ?m, high osmotic and mechanic stability, a high rate of adsorption and regeneration, and excellent dynamic characteristics as filtering media. Inparticular, this article discusses the use of FIBAN fibrous ion exchangers in the recovery of gold cyanide andbase-metal cyanides (copper and mercury) from mineral-leaching solutions. The influence of polymer structure and water content on their extraction ability is described, along with key parameters of gold hydrometallurgy such as extraction efficiency, selectivity, pH dependence, gold cyanide loading, kinetics, and stripping.

  12. Modeling Ablation of Fibrous Materials from Bulk to Knudsen Regime

    Science.gov (United States)

    Lachaud, Jean; Mansour, Nagi N.

    2008-01-01

    Material-environment interactions are analyzed at microscopic scale to explain the lower than expected density observed by post-flight analysis of the char layer on the Stardust shield. Mass transfer, ablation (oxidation), and surface recession of fibrous material is simulated in 3D using a Monte-Carlo simulation tool. Ablation is found to occur either at the surface or in volume depending on Knudsen and Thiele number values. This study supports the idea of volume ablation followed by possible carbon fiber spallation that may explain post-flight analyses.

  13. Development of fibrous monoliths from mullite, alumina, and zirconia powders

    Energy Technology Data Exchange (ETDEWEB)

    Polzin, B. J.; Cruse, T. A.; Singh, D.; Picciolo, J. J.; Tsaliagos, R. N.; Phelan, P. J.; Goretta, K. C.

    2000-06-29

    Fibrous monoliths (FMs) based on mullite combined with Al{sub 2}O{sub 3} and Y{sub 2}O{sub 3}-stabilized ZrO{sub 2} have been produced. These FMs incorporate duplex cells in which compressive residual stresses were engineered into the surfaces of the cells. The residual stresses should increase average cell strength, which may allow them to achieve mechanical properties comparable to those of Si{sub 3}N{sub 4}/BN FMs. The expected residual stresses have been calculated, and data on sintering and thermal expansion have been gathered. Prototype FMs were produced and their microstructure examined.

  14. Polyostotic fibrous dysplasia associated with intramuscular myxomas: Mazabraud syndrome

    Directory of Open Access Journals (Sweden)

    Jose Daniel Samper Wamba

    2015-01-01

    Full Text Available The authors report a new case of Mazabraud syndrome in a 69-year-old woman complaining of pain in her right thigh. Plain radiographs demonstrated radiological findings consistent with polyostotic fibrous dysplasia of the right femur and tibia. Magnetic resonance imaging (MRI study showed soft tissue tumors located in the vastus intermedius muscle with typical signal features of intramuscular myxomas. Biopsy was not performed because of its benign nature. Symptomatic treatment was prescribed and all the lesions remained 1 year after the diagnosis.

  15. Undetermined Fibrous Tumor with Calcification in the Cerebellopontine Angle

    OpenAIRE

    Cheon, Se Hun; Kang, Shin-Hyuk; Park, Kyung Jae; Chung, Yong Gu

    2010-01-01

    In this report, we introduce an undetermined fibrous tumor with calcification occurring in the cerebellopontine angle (CPA). A 51-year-old woman was admitted with a short history of dizziness. Computed tomography and magnetic resonance images revealed a 2×2×2 cm sized mass at the left CPA which was round and calcified. There was no dura or internal auditory canal involvement. At surgery, the tumor was located at the exit of 7th and 8th cranial nerve complex. It was very firm, bright yellow an...

  16. Uncommon breast lesions. Radiologic and pathologic findings

    International Nuclear Information System (INIS)

    To illustrate the radiologic findings in several uncommon breast and infrequent diseases that present with unusual mammographic images. We reviewed the mammograms performed in our department between 1998 and 1995, selecting 16 patients (12 women and 4 men). Nine patients had benign breast lesions (adenomyoepithelioma, epidermal cyst, adenoid cystic carcinoma, myofibroblastoma, multiple hamartomas, intra cystic papillomas, lipoma, idiopathic granulomatous mastitis and fat necrosis) and 7 patients presented malignant breast diseases (malignant fibrous histiocytoma, intra cystic carcinoma, primary lymphoma of the breast, liposarcoma and metastasis). We present a review of the radiologic and pathologic findings in several uncommon breast diseases. (Author) 14 refs

  17. CT findings of retroperitoneal masses

    International Nuclear Information System (INIS)

    Retrospective analysis of forty one retroperitoneal masses was made with computed tomography. All cases were confirmed pathologically by operation or needle aspiration biopsy. The cases were; 14 abscesses, 2 leiomyosarcomas, 2 rhabdomyosarcomas, 2 liposarcomas, 1 undifferentiated sarcoma, 3 endodermal sinus tumors, 4 teratomas, 2 neurofibromas, 1 neurilemoma, 3 neuroblastomas, 4 malignant lymphomas, 2 malignant fibrous histiocytomas and 1 hemangiopericytoma. Tumors originated from urinary tract and pancreas were not included. Findings favor tumor rather than inflammation were; large lobulated soft tissue mass with eccentric or heterogeneous low density, thick cavity wall, disruption of fascial planes, regional lymphnode enlargement and distant metastasis

  18. A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots

    Directory of Open Access Journals (Sweden)

    Yong Yan Wang

    2011-10-01

    Full Text Available The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus. From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-?-D-glucopyranoside and three known glycosides [1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (liriopeoside A, 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside, and 1?,6?-dihydroxy-5,10-bis-epi-eudesm-4(15-ene-6-O-? D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-?-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC50 value of 339.76 ?g/mL, while liriopeoside A (LC50 = 82.84 ?g/mL and 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (LC50 = 153.39 ?g/mL also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC50 value of 182.56 ?g/mL.

  19. A micromechanics finite-strain constitutive model of fibrous tissue

    Science.gov (United States)

    Chen, Huan; Liu, Yi; Zhao, Xuefeng; Lanir, Yoram; Kassab, Ghassan S.

    2011-09-01

    Biological tissues have unique mechanical properties due to the wavy fibrous collagen and elastin microstructure. In inflation, a vessel easily distends under low pressure but becomes stiffer when the fibers are straightened to take up the load. The current microstructural models of blood vessels assume affine deformation, i.e., the deformation of each fiber is assumed to be identical to the macroscopic deformation of the tissue. This uniform-field (UF) assumption leads to the macroscopic (or effective) strain energy of the tissue that is the volumetric sum of the contributions of the tissue components. Here, a micromechanics-based constitutive model of fibrous tissue is developed to remove the affine assumption and to take into consideration the heterogeneous interactions between the fibers and the ground substance. The development is based on the framework of a recently developed second-order homogenization theory, and takes into account the waviness, orientations and spatial distribution of the fibers, as well as the material nonlinearity at finite-strain deformation. In an illustrative simulation, the predictions of the macroscopic stress-strain relation and the statistical deformation of the fibers are compared to the UF model, as well as finite-element (FE) simulation. Our predictions agree well with the FE results, while the UF predictions significantly overestimate. The effects of fiber distribution and waviness on the macroscopic stress-strain relation are also investigated. The present mathematical model may serves as a foundation for native as well as for engineered tissues and biomaterials.

  20. Heat Transfer Modeling for Rigid High-Temperature Fibrous Insulation

    Science.gov (United States)

    Daryabeigi, Kamran; Cunnington, George R.; Knutson, Jeffrey R.

    2012-01-01

    Combined radiation and conduction heat transfer through a high-temperature, high-porosity, rigid multiple-fiber fibrous insulation was modeled using a thermal model previously used to model heat transfer in flexible single-fiber fibrous insulation. The rigid insulation studied was alumina enhanced thermal barrier (AETB) at densities between 130 and 260 kilograms per cubic meter. The model consists of using the diffusion approximation for radiation heat transfer, a semi-empirical solid conduction model, and a standard gas conduction model. The relevant parameters needed for the heat transfer model were estimated from steady-state thermal measurements in nitrogen gas at various temperatures and environmental pressures. The heat transfer modeling methodology was evaluated by comparison with standard thermal conductivity measurements, and steady-state thermal measurements in helium and carbon dioxide gases. The heat transfer model is applicable over the temperature range of 300 to 1360 K, pressure range of 0.133 to 101.3 x 10(exp 3) Pa, and over the insulation density range of 130 to 260 kilograms per cubic meter in various gaseous environments.

  1. Modeling tortuosity in fibrous porous media using computational fluid dynamics

    Science.gov (United States)

    Vallabh, Rahul

    Tortuosity factor is often used to characterize the structure of the pore volume in fibrous porous media. This work involves the determination of tortuosity using computational fluid dynamic (CFD) simulation and particle tracking analysis. A new method has been adopted to generate 3-D geometry for modeling fibrous porous structures using ANSYSRTM Parametric Design Language (APDL). Computation fluid dynamics has been used to simulate permeability of modeled 3-D fiberweb structures. The simulated permeability results are in good agreement with the models proposed by other authors. The experimental results were found to be slightly higher compared to simulated results and existing models due to the layered configuration of the samples. Permeability is found to be significantly influenced by fiber diameter, and porosity as well as fiberweb thickness. The relationship between air permeability and fiberweb thickness has been used to develop an indirect method for determination of tortuosity factor. Tortuosity factor has also been determined using a more direct method involving CFD simulation and Particle Tracking analysis. Different models established using the direct and indirect methods of determination show that tortuosity is significantly influenced by porosity, fiber diameter and fiberweb thickness, whereas the models available in the literature express tortuosity as a function of porosity only.

  2. Malignant eroticized countertransference.

    Science.gov (United States)

    Chessick, R D

    1997-01-01

    Gabbard (1994) divided the pathology of therapists, both male and female, who commit sexual boundary violations into those who are psychotic, those who are predatory psychopaths, those engaging in masochistic surrender, and those called "the lovesick therapist." Lovesick therapists are the most common type and manifest crucial narcissistic themes of "a desperate need for validation by their patients, a hunger to be loved and idealized, and a tendency to use patients to regulate their own self-esteem" (p. 127). Among the psychodynamic aspects of this curiously circumscribed area of loss of reality testing that makes it difficult for the therapist to see how self-destructive and harmful such enactment is, are an unconscious reenactment of incestuous longings, a misperception of the patient's wish for maternal nurturance as a sexual overture, enactments of rescue fantasies, a projected idealization of the self of the therapist, a confusion of the therapist's needs with the patient's needs, a fantasy that love is curative, acting out disavowed rage at the patient, or rage at an organization, an institute, or one's training analyst, a manic defense against mourning, a narcissistic fantasy that their sexual affair is an exception, insecurity regarding masculine identity, and assorted primitive preoedipal themes. Gabbard's (1991) erotized countertransference is one variety of what I have termed malignant eroticized countertransference. His variety is a development that occurs under the pressure of the patient's preemptive and compelling expressions of lust and love, the patient's erotic transference. But malignant eroticized countertransference can also occur without the patient having offered any such expressions; it can even occur on first meeting the patient when he or she walks into the office! This is akin to the romantic "love-at-first-sight" theme so favored in the movies and by novelists, but it is always pathological when it occurs in the therapeutic situation. Countertransference enactments are a creation between the patient and the therapist on a continuum from one pole, where the patient has just walked into the office and contributes almost nothing directly, to the other pole, where the therapist loses control of himself or herself as a response to the unbearable pressure of the patient's lust. In the treatment of malignant eroticized countertransference it seems clear from this discussion that every case should be evaluated psychodynamically and the treatment should be made to fit the patient, not the patient to the treatment. Each situation should be studied in psychodynamic depth without preconceptions based on generalizations or formulas. Therapists who are psychotic should of course be treated with antipsychotic drugs and usually should not be allowed to practice any further. Therapists who are psychopathic or sociopathic predators should certainly never be allowed to practice. Some of the individuals who are "lovesick," or, as I put it "love/lust obsessed," or those who have made a masochistic surrender to a sadistic destructive patient, are in need of reanalysis and have the potential to continue as effective therapists under careful supervision. Therapists like this do not deserve to be summarily dismissed from the profession but, like therapists who develop other serious neurotic problems, should receive appropriate help from us. PMID:9395991

  3. High-surface-area silica nanospheres (KCC-1) with a fibrous morphology

    KAUST Repository

    Polshettiwar, Vivek

    2010-08-02

    Fibrous nanosilica: A new family of high-surface-area silica nanospheres (KCC-1) have been prepared (see picture). KCC-1 features excellent physical properties, including high surface area, unprecedented fibrous surface morphology, high thermal (up to 950 °C) and hydrothermal stabilities, and high mechanical stability. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Low level hydrogen peroxide generation from a nonwoven fibrous pectin-cellulose blend

    Science.gov (United States)

    Fibrous pectic-cellulose (FPC) (cellulose blended with primary cell wall pectin at 2 percent by weight of pectin) is product made from naturally occurring plant fibers. FPC is a fibrous mixture of polysaccharides with a low percent by weight of pectin-based primary cell wall and lipid components att...

  5. Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2.

    Science.gov (United States)

    Chokoeva, A A; Tchernev, G; Cardoso, J C; Patterson, J W; Dechev, I; Valkanov, S; Zanardelli, M; Lotti, T; Wollina, U

    2015-06-01

    Malignant tumors of the female reproductive system are a serious health and social problem, as they are the second most common cause of death among women, after breast cancer. Vulvar tumors represent only 4% of all gynecological neoplasms, and they are fourth in frequency after tumors of the cervix, uterus, and ovary. Ninety-eight percent of all vulvar tumors are benign and only 2% are malignant. Sarcomas of the vulva comprise approximately 1-3% of all vulvar cancers. They are characterized by rapid growth, high metastatic potential, frequent recurrences, aggressive behavior, and high mortality rate. In Part 1 of this paper, we presented the most common forms of sarcoma of the vulva: leiomyosarcoma, epithelioid sarcoma, malignant rhabdoid tumor, and rhabdomyosarcoma. The second part of this review will focus mainly on the rarest variants of vulvar sarcoma: low-grade fibromyxoid sarcoma, synovial sarcoma, monophasic synovial sarcoma, carcinosarcoma, Ewing sarcoma, myeloid sarcoma, dermatofibrosarcoma protuberans, malignant fibrous histiocytoma, angiomatoid fibrous histiocytoma, liposarcoma, malignant peripheral nerve sheath tumor, and malignant mesothelioma. PMID:25816393

  6. Malignant melanoma of the vagina.

    OpenAIRE

    Rahat ARA; Saw OHNMAR

    2011-01-01

    Carcinoma of the vagina is uncommon and only constitutes two percent of malignant neoplasms of the female genital tract. Malignant melanoma of the vagina is rarer and accounts for only 3.2% of all vaginal cancers. It presumably arises from melanocytes found in the vagina of three percent of normal women. It is a very aggressive tumour and the overall prognosis is poor despite the treatment. We report the case of an 81-year-old woman who presented with per vagina bleeding secondary to a malign...

  7. Fibrous scar in the infrapatellar fat pad after arthroscopy. MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Guangyu; Niitsu, Mamoru; Ikeda, Kotaro; Itai, Yuji [Tsukuba Univ., Ibaraki (Japan). Inst. of Clinical Medicine; Endo, Hideho

    2000-02-01

    We describe the MR appearance of fibrous scars in the infrapatellar fat pad after arthroscopy. The subjects were 96 patients who underwent arthroscope-assisted anterior cruciate ligament (ACL) reconstruction and were examined by oblique sagittal MR imaging at different follow-up intervals. Two observers evaluated the characteristics of the fibrous scars in the infrapatellar fat pad. All fibrous scars with low signal intensity were accentuated at the portal and coursed horizontally through the infrapatellar fat pad. The fibrous scar within the fat pad occurred and peaked within 6 months after arthroscopy. It then subsided gradually and had disappeared by one year later in nearly half of the patients. Identifying MR imaging characteristics of fibrous scars in the fat pad after arthroscopy may be clinically helpful to differentiate these scars from other abnormalities that involve the infrapatellar fat pad. (author)

  8. Fibrous scar in the infrapatellar fat pad after arthroscopy. MR imaging

    International Nuclear Information System (INIS)

    We describe the MR appearance of fibrous scars in the infrapatellar fat pad after arthroscopy. The subjects were 96 patients who underwent arthroscope-assisted anterior cruciate ligament (ACL) reconstruction and were examined by oblique sagittal MR imaging at different follow-up intervals. Two observers evaluated the characteristics of the fibrous scars in the infrapatellar fat pad. All fibrous scars with low signal intensity were accentuated at the portal and coursed horizontally through the infrapatellar fat pad. The fibrous scar within the fat pad occurred and peaked within 6 months after arthroscopy. It then subsided gradually and had disappeared by one year later in nearly half of the patients. Identifying MR imaging characteristics of fibrous scars in the fat pad after arthroscopy may be clinically helpful to differentiate these scars from other abnormalities that involve the infrapatellar fat pad. (author)

  9. FIBROUS DYSPLASIA OF PROXIMAL PHALANX OF HAND A RADIOLOGICAL DIAGNOSIS AND HISTOPATHOLOGICAL CONFIRMATION

    Directory of Open Access Journals (Sweden)

    Shobha

    2014-05-01

    Full Text Available Fibrous dysplasia is a benign skeletal developmental anomaly, which is manifested as a defect in osteoblastic differentiation and maturation of a normal bone that leads to structurally weak fibrous and osseous (bone-like tissue. In normal bone formation, woven bone appears first and later matures into lamellar bone and in fibrous dysplasia, bone does not mature and development stops in the woven bone stage. Most commonly involved bones are femur, tibia, pelvis, ribs and skull. Small bones of hands or feet are rarely involved. This disorder is usually diagnosed in childhood or early adulthood and can affect one or several bones. Histopathology reveals abundant amount of fibrous tissue and disorganized bony trabeculae and spindle cells. Normal bone pattern is not demonstrated. Here we report a very rare case of fibrous dysplasia involving proximal phalanx of the hand diagnosed on radiological features with histopathological confirmation.

  10. [Not diagnosable malignant melanomas].

    Science.gov (United States)

    Neuber, H; Lippold, A; Hundeiker, M

    1991-04-01

    Of the 3574 malignant melanomas treated in Hornheide between December 1981 and August 1990 (not including preinvasive cases) 97 were not immediately recognized. These tumours did not look like melanomas. In 72% they were smaller than 10 mm in diameter, and in 20%, smaller than 5 mm. Clark's so often quoted "pencil rule" should no longer be used as an aid to exclusion of invasive melanoma. Localization of the unrecognized melanomas was on the head and neck in 22% of cases. In 37%, the patients were under the age of 40 years. No less than 25% of the patients had multiple melanomas. Many of these melanomas. Many of these melanomas were thin tumours (less than 0.75 mm in 55% and less than 1.5 mm in 77%). This explains why more than 50% of the lesions are described as "macules". The most common incorrect diagnoses were dysplastic naevi (44%) and common (23%) naevi. The most important anamnestic criteria are the patients' own statements about changes in size, colour and shape. These "dynamic" elements must be more carefully observed and documented during process of the clinical diagnosis. PMID:1860796

  11. The differentiation of malignant and benign musculoskeletal tumors by F-18 FDG PET/CT studies-determination of maxSUV by analysis of ROC curve

    International Nuclear Information System (INIS)

    We evaluated the standard uptake value (SUV) of F-18 FDG at PET/CT for differentiation of benign from malignant tumor in primary musculoskeletal tumors. Forty-six tumors (11 benign and 12 malignant soft tissue tumors, 9 benign and 14 malignant bone tumors) were examined with F-18 FDG PET/CT (Discovery ST, GE) prior to tissue diagnosis. The maxSUV(maximum value of SUV) were calculated and compared between benign and malignant lesions. The lesion analysis was based on the transverse whole body image. The maxSUV with cutoff of 4.1 was used in distinguishing benign from malignant soft tissue tumor and 3.05 was used in bone tumor by ROC curve. There was a statistically significant difference in maxSUV between benign (n = 11; maxSUV 3.4 ± 3.2) and malignant (n = 12; maxSUV 14.8 ± 12.2) lesion in soft tissue tumor (? = 0.001). Between benign bone tumor (n = 9; maxSUV 5.4 ± 4.0) and malignant bone tumor (n = 14; maxSUV 7.3 ± 3.2), there was not a significant difference in maxSUV. The sensitivity and specificity for differentiating malignant from benign soft tissue tumor was 83% and 91%, respectively. There were four false positive malignant bone tumor cases to include fibrous dysplasia, Langerhans-cell histiocytosis (n = 2) and osteoid osteoma. Also, one false positive case of malignant soft tissue tumor was nodular fasciitis. The maxSUV was useful for differentiation of benign from malignant lesion in primary soft tissue tumors. In bone tumor, the low maxSUV correlated well with benign lesions but high maxSUV did not always mean malignancy

  12. The differentiation of malignant and benign musculoskeletal tumors by F-18 FDG PET/CT studies-determination of maxSUV by analysis of ROC curve

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Eun Jung; Cho, Ihn Ho; Chun, Kyung Ah; Won, Kyu Chang; Lee, Hyung Woo; Choi, Jun Heok; Shin, Duk Seop [Yeungnam University College of Medicine, Daegu (Korea, Republic of)

    2007-12-15

    We evaluated the standard uptake value (SUV) of F-18 FDG at PET/CT for differentiation of benign from malignant tumor in primary musculoskeletal tumors. Forty-six tumors (11 benign and 12 malignant soft tissue tumors, 9 benign and 14 malignant bone tumors) were examined with F-18 FDG PET/CT (Discovery ST, GE) prior to tissue diagnosis. The maxSUV(maximum value of SUV) were calculated and compared between benign and malignant lesions. The lesion analysis was based on the transverse whole body image. The maxSUV with cutoff of 4.1 was used in distinguishing benign from malignant soft tissue tumor and 3.05 was used in bone tumor by ROC curve. There was a statistically significant difference in maxSUV between benign (n = 11; maxSUV 3.4 {+-} 3.2) and malignant (n = 12; maxSUV 14.8 {+-} 12.2) lesion in soft tissue tumor ({rho} = 0.001). Between benign bone tumor (n = 9; maxSUV 5.4 {+-} 4.0) and malignant bone tumor (n = 14; maxSUV 7.3 {+-} 3.2), there was not a significant difference in maxSUV. The sensitivity and specificity for differentiating malignant from benign soft tissue tumor was 83% and 91%, respectively. There were four false positive malignant bone tumor cases to include fibrous dysplasia, Langerhans-cell histiocytosis (n = 2) and osteoid osteoma. Also, one false positive case of malignant soft tissue tumor was nodular fasciitis. The maxSUV was useful for differentiation of benign from malignant lesion in primary soft tissue tumors. In bone tumor, the low maxSUV correlated well with benign lesions but high maxSUV did not always mean malignancy.

  13. Malignant melanoma and other malignancies of the nasal cavity and the paranasal sinuses in Sweden

    OpenAIRE

    Jangard, Mattias

    2014-01-01

    Background: Malignancies emerging in the nasal cavity and the paranasal sinuses are rare and accounts for 5% of all head and neck malignancies and 0.1% of all malignancies in Sweden. The incidence of sinonasal malignancy (SNM), except sinonasal malignant melanoma (SNMM), has been reported to decrease since 1960 in Sweden. Despite similar improvement in the prognosis of other malignancies, treatment of SNM still yields a poor survival outcome. About 1–2% of all malignant melanomas origin...

  14. Drugs Approved for Malignant Mesothelioma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for malignant mesothelioma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  15. Malignant melanoma of the vagina.

    Directory of Open Access Journals (Sweden)

    Rahat ARA

    2011-10-01

    Full Text Available Carcinoma of the vagina is uncommon and only constitutes two percent of malignant neoplasms of the female genital tract. Malignant melanoma of the vagina is rarer and accounts for only 3.2% of all vaginal cancers. It presumably arises from melanocytes found in the vagina of three percent of normal women. It is a very aggressive tumour and the overall prognosis is poor despite the treatment. We report the case of an 81-year-old woman who presented with per vagina bleeding secondary to a malignant melanoma of the vagina. She was treated with radiotherapy as her disease was locally extensive and she was not a candidate for pelvis exenteration. This is the first recorded case of malignant melanoma to be diagnosed in Brunei Darussalam.

  16. Malignant Peripheral Nerve Sheath Tumors

    OpenAIRE

    FARID, MOHAMAD; Demicco, Elizabeth G.; Garcia, Roberto; Ahn, Linda; Merola, Pamela R.; Cioffi, Angela; Maki, Robert G.

    2014-01-01

    Malignant peripheral nerve sheath tumors are amongst the most challenging mesenchymal malignancies to treat. Their frequent association with a seemingly simple genetic aberration—the loss of the tumor suppressor gene neurofibromin—belies genomic complexity that has rendered effective therapy elusive to date. This review aims to detail elements of current optimal clinical management and summarize recent data on potential molecular drivers and targets, with a view to charting the course for fut...

  17. Malignant schwannoma of the rectum

    International Nuclear Information System (INIS)

    Malignant schwannomas are rare. These malignomas are primary nerve sheath tumors that usually arise from a peripheral nerve. They appear most frequently in the lower extremities, including the hips and buttocks (34.8%), the upper extremities (23.4%), and in the trunk (17%). To the best of our knowledge, this is the first reported case of a malignant schwannoma of the rectum. We describe the rare disease with reference to the literature. (orig.)

  18. Malignant hyperthermia: a review.

    Science.gov (United States)

    Rosenberg, Henry; Pollock, Neil; Schiemann, Anja; Bulger, Terasa; Stowell, Kathryn

    2015-01-01

    Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane, isoflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stressors such as vigorous exercise and heat. The incidence of MH reactions ranges from 1:10,000 to 1: 250,000 anesthetics. However, the prevalence of the genetic abnormalities may be as great as one in 400 individuals. MH affects humans, certain pig breeds, dogs and horses. The classic signs of MH include hyperthermia, tachycardia, tachypnea, increased carbon dioxide production, increased oxygen consumption, acidosis, hyperkalaemia, muscle rigidity, and rhabdomyolysis, all related to a hypermetabolic response. The syndrome is likely to be fatal if untreated. An increase in end-tidal carbon dioxide despite increased minute ventilation provides an early diagnostic clue. In humans the syndrome is inherited in an autosomal dominant pattern, while in pigs it is autosomal recessive. Uncontrolled rise of myoplasmic calcium, which activates biochemical processes related to muscle activation leads to the pathophysiologic changes. In most cases, the syndrome is caused by a defect in the ryanodine receptor. Over 400 variants have been identified in the RYR1 gene located on chromosome 19q13.1, and at least 34 are causal for MH. Less than 1 % of variants have been found in CACNA1S but not all of these are causal. Diagnostic testing involves the in vitro contracture response of biopsied muscle to halothane, caffeine, and in some centres ryanodine and 4-chloro-m-cresol. Elucidation of the genetic changes has led to the introduction of DNA testing for susceptibility to MH. Dantrolene sodium is a specific antagonist and should be available wherever general anesthesia is administered. Increased understanding of the clinical manifestation and pathophysiology of the syndrome, has lead to the mortality decreasing from 80 % thirty years ago to <5 % in 2006. PMID:26238698

  19. Polyelectrolyte-complex nanostructured fibrous scaffolds for tissue engineering

    International Nuclear Information System (INIS)

    In the current work, polyelectrolyte complex (PEC) fibrous scaffolds for tissue engineering have been synthesized and a mechanism of their formation has been investigated. The scaffolds are synthesized using polygalacturonic acid and chitosan using the freeze drying methodology. Highly interconnected pores of sizes in the range of 5-20 ?m are observed in the scaffolds. The thickness of the fibers was found to be in the range of 1-2 ?m. Individual fibers have a nanogranular structure as observed using AFM imaging. In these scaffolds, PEC nanoparticles assemble together at the interface of ice crystals during freeze drying process. Further investigation shows that the freezing temperature and concentration have a remarkable effect on structure of scaffolds. Biocompatibility studies show that scaffold containing chitosan, polygalacturonic acid and hydroxyapatite promotes cell adhesion and proliferation. On the other hand, cells on scaffolds fabricated without hydroxyapatite nanoparticles showed poor adhesion.

  20. Determination of physical properties of fibrous thermal insulation

    Directory of Open Access Journals (Sweden)

    Jeandel G.

    2012-10-01

    Full Text Available The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a device developed in house. The radiative properties of the material are determined by an inverse method based on measurements of transmittance and reflectance using a FTIR spectrometer and by solving the equation of radiative heat transfer. These measures are compared to results of numerical simulations.

  1. A theoretical analysis of local thermal equilibrium in fibrous materials

    Directory of Open Access Journals (Sweden)

    Tian Mingwei

    2015-01-01

    Full Text Available The internal heat exchange between each phase and the Local Thermal Equilibrium (LTE scenarios in multi-phase fibrous materials are considered in this paper. Based on the two-phase heat transfer model, a criterion is proposed to evaluate the LTE condition, using derived characteristic parameters. Furthermore, the LTE situations in isothermal/adiabatic boundary cases with two different heat sources (constant heat flux and constant temperature are assessed as special transient cases to test the proposed criterion system, and the influence of such different cases on their LTE status are elucidated. In addition, it is demonstrated that even the convective boundary problems can be generally estimated using this approach. Finally, effects on LTE of the material properties (thermal conductivity, volumetric heat capacity of each phase, sample porosity and pore hydraulic radius are investigated, illustrated and discussed in our study.

  2. Determination of physical properties of fibrous thermal insulation

    Science.gov (United States)

    Tilioua, A.; Libessart, L.; Joulin, A.; Lassue, S.; Monod, B.; Jeandel, G.

    2012-10-01

    The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET) with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool) are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a device developed in house. The radiative properties of the material are determined by an inverse method based on measurements of transmittance and reflectance using a FTIR spectrometer and by solving the equation of radiative heat transfer. These measures are compared to results of numerical simulations.

  3. Filtration efficiency of a fibrous filter for nanoparticles

    International Nuclear Information System (INIS)

    The filtration efficiency for nanoparticles down to 1 nm in size through glass fibrous filters was measured using an improved PSM-CNC system. In addition, the effects of relative humidity and particle charge were investigated for various nanoparticle diameters. The results show that the filtration efficiencies were independent of humidity and affected by particle charge in the case of particles below 100 nm in size. For particles smaller than 2 nm, the particle penetrations increased with decreasing particle size. These results suggest that the thermal rebound phenomena would be operative for nanoparticles with diameters below 2 nm, even though it would depend on the states of both the particles and the filter media. These results are particularly important for experimental investigations of the behavior of nanoparticles on a filter

  4. Solitary fibrous tumor of the liver: a case report

    Directory of Open Access Journals (Sweden)

    Ying Li-Xiong

    2011-03-01

    Full Text Available Abstract Hepatic solitary fibrous tumor (SFT is a rare tumor originating from the mesenchyme. Here we report a new case of SFT in the liver and review the clinical presentation, radiological and operative findings, diagnosis, treatment, and outcome. The patient was a 59-year-old man who presented with progressive fatigue for 3 months and an abdominal mass for 3 days. On laboratory tests, no abnormality was detected except that abdominal ultrasonography revealed a 9.0 × 6.2 cm hypoechogenic mass in the left lobe of the liver. A computed tomographic scan confirmed a hypodense lesion in the left lobe of the liver. The patient underwent left hepatectomy. SFT was diagnosed on the basis of histopathological findings. The patient was free from all symptoms and had no signs of local recurrence after 24 months' follow up.

  5. Hyperostotic esthesioneuroblasma: Rare variant and fibrous dysplasia mimicker

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, Manzoor [Neuroradiology Section, Imaging Institute, Cleveland Clinic Foundation, Cleveland (United States); Knott, Phillip Daniel [Director of Facial Plastic and Reconstructive Surgery, Associate Professor of Otolaryngology, UCSF School of Medicine, San Fransisco (United States)

    2014-02-15

    A 65-year-old male presented with a 3-year history of orbital symptoms. An imaging-based diagnosis of fibrous dysplasia involving the skull base was made at another institution. CT showed a diffuse sinonasal mass and ground-glass appearance of the bones of the anterior skull base with bony defects and mucocele formation. MRI demonstrated an accompanying intracranial and orbital rind of soft tissue mass along the hyperostotic bones. FDG-PET showed corresponding intense hypermetabolism. Small cysts were observed at the tumor-brain interface. Biopsy revealed esthesioneuroblastoma with bone infiltration that is compatible with the hyperostotic variant of esthesioneuroblastoma. There are a few cases of hyperostotic esthesioneuroblastoma reported in the literature.

  6. Alumina composites for oxide/oxide fibrous monoliths

    International Nuclear Information System (INIS)

    Most work on ceramic fibrous monoliths (FMs) has focused on the Si3N4/BN system. In an effort to develop oxidation-resistant FMs, several oxide systems have recently been examined. Zirconia-toughened alumina and alumina/mullite appear to be good candidates for the cell phase of FMs. These composites offer higher strength and toughness than pure alumina and good high-temperature stability. By combining these oxides, possibly with a weaker high-temperature oxide as the cell-boundary phase, it should be possible to product a strong, resilient FM that exhibits graceful failure. Several material combinations have been examined. Results on FM fabrication and microstructural development are presented

  7. Focal fibrous overgrowths: A case series and review of literature

    Directory of Open Access Journals (Sweden)

    Abhay P Kolte

    2010-01-01

    Full Text Available Intraoral fibrous overgrowths of the soft tissues are relatively common and may be benign reactive or neoplastic lesions. A series of 10 lesions is presented which included pyogenic granuloma, fibroma and peripheral ossifying fibroma. Almost all the lesions occurred in the second and third decades and were present in the anterior segment of the jaws, with a distinct female predilection. Majority of these lesions were asymptomatic and the patients reported for treatment only due to the discomfort during function. Histopathologic examinations were done for diagnosis of these lesions. Surgical excision along with removal of causative irritants remains the treatment of choice. The extent of excision should depend on the severity of the lesion, as some of these lesions have a tendency for recurrence. All the patients in this series were closely followed up for a period of 2 years and showed no signs of recurrence.

  8. EXTRA PLEURAL SOLITARY FIBROUS TUMOR: A REPORT OF TWO CASES

    Directory of Open Access Journals (Sweden)

    Meenakumari

    2014-12-01

    Full Text Available : Solitary fibrous tumor (SFT belongs to a group of mesenchymal tumors, first described as a primary spindle cell tumor of the pleura in 1931. Recently, SFT has been reported in various locations with no relation to serosal surface. We describe two such cases in unusual sites of orbit and nasal cavity. Histopathologically, the tumors had a disorganized or “patternless” arrangement of spindle cells in a collagenous background and prominent vascular channels of varying sizes. Immunohistochemically both tumours showed CD 34 positivity. The two patients had benign clinical course with limited follow-up. SFT should be included in the differential diagnosis of spindle cell tumors arising in the nasal cavity and orbit.

  9. Creation of Hybrid Nanorods From Sequences of Natural Trimeric Fibrous Proteins Using the Fibritin Trimerization Motif

    Science.gov (United States)

    Papanikolopoulou, Katerina; van Raaij, Mark J.; Mitraki, Anna

    Stable, artificial fibrous proteins that can be functionalized open new avenues in fields such as bionanomaterials design and fiber engineering. An important source of inspiration for the creation of such proteins are natural fibrous proteins such as collagen, elastin, insect silks, and fibers from phages and viruses. The fibrous parts of this last class of proteins usually adopt trimeric, ?-stranded structural folds and are appended to globular, receptor-binding domains. It has been recently shown that the globular domains are essential for correct folding and trimerization and can be successfully substituted by a very small (27-amino acid) trimerization motif from phage T4 fibritin. The hybrid proteins are correctly folded nanorods that can withstand extreme conditions. When the fibrous part derives from the adenovirus fiber shaft, different tissue-targeting specificities can be engineered into the hybrid proteins, which therefore can be used as gene therapy vectors. The integration of such stable nanorods in devices is also a big challenge in the field of biomechanical design. The fibritin foldon domain is a versatile trimerization motif and can be combined with a variety of fibrous motifs, such as coiled-coil, collagenous, and triple ?-stranded motifs, provided the appropriate linkers are used. The combination of different motifs within the same fibrous molecule to create stable rods with multiple functions can even be envisioned. We provide a comprehensive overview of the experimental procedures used for designing, creating, and characterizing hybrid fibrous nanorods using the fibritin trimerization motif.

  10. Radiographic Differential Diagnosis Between The Fibrous Dysplasia And The Ossifying Fibroma

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Karp Shik [Dept. of Dental Radiology, College of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    1999-02-15

    The author observed and compared the radiographic features of 49 cases of the fibrous dysplasia and 14 cases of the ossifying fibroma in the osteoblastic or mature stage radiologically and histopathologically. The obtained results were as follows: 1. Fibrous dysplasia occurred most frequently in the 2nd decade, but ossifying fibroma in the 3rd and 4th decades, and both lesions occurred with slight predilection in females. 2. In most cases, chief complaints were painless facial swelling. And 61.1% of fibrous dysplasia occurred in the maxilla, 92.9% of ossifying fibroma in the mandible, and most of these lesions occurred in the premolar-molar region. 3. In the mandibular lesions, ossifying fibroma was shown more oval and round shape, but fibrous dysplasia was shown fusiform shape. 4. Fibrous dysplasia was shown homogeneously distributed, complete radiopaque shadow at 63%, and ossifying fibroma was shown concentric, mixed appearance of radiolucent and radiopaque shadow at 92.9%. 5. Fibrous dysplasia was entirely shown poorly outlined and blended to normal surrounding bone, but ossifying fibroma was shown well-defined border. 6. Cortical thinning and expansion were observed in these lesions, but degree of cortical expansion was more severe in ossifying fibroma than fibrous dysplasia. 7. Loss of lamina dura, tooth displacement, and displacement of mandibular canal were observed in both lesions, but root resorption was observed in ossifying fibroma only.

  11. Solitary fibrous tumor with giant multinucleated cells in the retroperitoneum - A case report

    Directory of Open Access Journals (Sweden)

    Amel Trabelsi

    2009-10-01

    Full Text Available Context: Solitary fibrous tumor is a distinct neoplasm, rarely recognized in extrathoracic sites. Case report: The article reports a new case in the retroperitoneum in a 55 year-old man, who presented with urinary symptoms. Tumor was completely excised, and the solitary fibrous tumor was diagnosed after pathologic examination and immunohistochemistry. The patient has remained free of disease for five years since surgery. Conclusion: An uncommon variant of retroperitoneal solitary fibrous tumor with giant multinucleated cells was documented in the study.

  12. A large infiltrating fibrous hamartoma of infancy in the abdominal wall with rare associated tuberous sclerosis

    International Nuclear Information System (INIS)

    Tuberous sclerosis is a complex autosomal-dominant neurocutaneous syndrome characterized by hamartomatous malformations of fibrous and connective tissues in various organs. Although various histologic types of soft-tissue masses can occur with tuberous sclerosis, we present a unique case of fibrous hamartoma of infancy presenting as large infiltrating cutaneous and subcutaneous masses in the abdominal wall in a 4-year-old boy with tuberous sclerosis. Although the co-occurrence of tuberous sclerosis and fibrous hamartoma of infancy is very rare, it should be considered in the differential diagnosis of subcutaneous soft-tissue masses found in children with tuberous sclerosis. (orig.)

  13. Effect of Fibrous Concrete Layers on Behavior of Self-Compacting Concrete Slabs under Uniform Load

    OpenAIRE

    Dr. Ahmed S. D. AL-Ridha

    2014-01-01

    This research study the effect of using fibrous concrete layers on behavior of two way Self-Compacting Concrete slabs with ratio (length/width) ?1.618 [golden ratio] using steel fiber. The experimental work can be divided in two groups, each group having steel fiber–volume fractions of 0.4% and 0.8%, moreover both groups having two concrete slabs one with two fibrous layers (bottom + top) and the other with one fibrous layer (bottom), in additional to concrete slab without ste...

  14. Primary malignant small bowel tumor

    International Nuclear Information System (INIS)

    Small bowel tumors are rarely detected unless there is intestinal obstruction or bleeding. In the seven years 1982-1988, at Kosin Medical Center, 25 primary malignant small bowel tumors were studied radiographically with barium and / or computed tomography (CT). CT revealed gastrointestinal abnormalities in 20 patients. In ten, lesion were identified by upper G-I series, in 15 by small bowel series, and in addition, in 3 by colon enema. The most common malignant small bowel tumor was adenocarcinoma (N=15) and was next common lymphoma (N=7). On barium study, primary adenocarcinoma appeared as an irregular stricture (66.7%) and polypoid mass with intussusception was most prominent finding in lymphoma. Leiomyosarcoma appeared as an exophytic mass with excavation or ulceration. CT was found to be accurate in detecting wall thickening, complications and other associated findings. In conclusion, barium study was useful in the diagnosis of primary malignant small bowel tumor and CT was more accurate in detecting secondary findings

  15. Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics.

    Science.gov (United States)

    Schaefer, Inga-Marie; Fletcher, Christopher Dm; Hornick, Jason L

    2016-01-01

    The diagnosis of malignant peripheral nerve sheath tumor is challenging, particularly in the sporadic setting. Inactivation of the polycomb repressive complex 2 (PRC2), resulting from inactivating mutations of its constituents SUZ12 or EED1, has recently been identified in 70-90% of malignant peripheral nerve sheath tumors. Homozygous PRC2 inactivation results in loss of histone H3K27 trimethylation (H3K27me3). PRC2 inactivation promotes tumor progression and may render patients sensitive to epigenetic-based targeted therapies. H3K27me3 loss has not yet been validated as a diagnostic marker. We evaluated immunohistochemistry for H3K27me3 in 100 malignant peripheral nerve sheath tumors (70 sporadic, 10 neurofibromatosis type 1-associated, 10 radiation-associated, 10 epithelioid) and 200 other spindle cell neoplasms representing potential mimics (20 each monophasic synovial sarcoma, leiomyosarcoma, dedifferentiated liposarcoma, malignant solitary fibrous tumor, low-grade fibromyxoid sarcoma, cellular schwannoma, spindle cell melanoma, unclassified postradiation sarcoma; 10 each atypical neurofibroma, spindle cell rhabdomyosarcoma, gastrointestinal stromal tumor, fibrosarcomatous dermatofibrosarcoma protuberans). In total, 51 (51%) malignant peripheral nerve sheath tumors, including 34 (49%) sporadic, 7 (70%) neurofibromatosis type 1-associated, and 10 (100%) radiation-associated, but no epithelioid malignant peripheral nerve sheath tumors, were negative for H3K27me3. An additional 6 (6%) tumors showed heterogeneous H3K27me3 expression. Among the 90 sporadic, neurofibromatosis type 1-associated, and radiation-associated malignant peripheral nerve sheath tumors, complete H3K27me3 loss was observed in 29% of low-grade, 59% of intermediate-grade, and 83% of high-grade tumors (low vs intermediate/high grade, P=0.0003). Among other tumor types, 4 (20%) unclassified postradiation sarcomas were negative for H3K27me3, whereas all other neoplasms were positive. Loss of H3K27me3 is highly specific for malignant peripheral nerve sheath tumor (although only modestly more sensitive than S-100 protein and SOX10) and may be a useful diagnostic marker. Our findings suggest that PRC2 inactivation in malignant peripheral nerve sheath tumor may occur during progression to higher grades. PMID:26585554

  16. Malignant diseases as suicidal motives

    Directory of Open Access Journals (Sweden)

    Bogdanovi? Ljiljana

    2007-01-01

    Full Text Available Introduction Suicide is a conscious and intentional destruction of one’s own life, which occurs as a result of mutual influence of a person’s disposition and motives (facts inspiring the commitment of suicide. It is well known that various diseases, including malignancies, could be important and in some cases the only motive for committing suicide. Objective The purpose of the study was to analyze in detail suicides of persons whose only motive was an established malignant disease. Method The analysis was performed using the autopsy material of the Institute of Forensic Medicine, School of Medicine, University of Belgrade, during the period from 1990 to 2004. The reports on performed medico-legal autopsies were used, as well as history data obtained from the family members of suicidal persons, investigation reports and the available medical documents. Results In 1931 cases there was established suicidal nature of a violent death. Neoplasms were the suicidal motive in 37 persons (1.9%. The basic characteristics of the analyzed sample were predominance of males (26:11, ratio 2.4:1, the age of over 70 years and the highest incidence of malignant lung and breast tumors. Almost all cases were the persons who underwent treatment for malignant neoplasms over a longer period of time. During 19 autopsies (51.3% out of 37, a progressive phase of malignancy was established, i.e. metastases. The data on prior oral announcement of suicide intention were obtained for 70.3% (26 cases, and on previous suicidal attempts only for 13.5% (5 cases. In the majority of cases (78.4% the place of committed suicide was the person’s home. In 16 cases (43.2% the suicide was committed with a firearm. Hanging as a manner of destroying one’s own life was chosen by 12 persons (32.4%, while other ways were less frequently used. Conclusion Although malignancies were not present with high incidence as a suicidal motive in our analyzed sample, such cases require particular care of health workers in order to enable the application of adequate measures in the prevention of suicides in persons with malignant diseases. The suicide analyses performed so far indicated that a malignant disease was the motive. Doctors have to show maximal interest for the patient. Prevention is crucial, so the patient should be provided with such surroundings in which the person will not feel alone and abandoned.

  17. RECEPTION OF NANOPARTICLES OF SILVER FOR USE IN MANUFACTURE OF FIBROUS COVERS ????????? ?????????? ??????? ??? ????????????? ? ???????????? ?????????? ????????

    Directory of Open Access Journals (Sweden)

    Gorlov I. F.

    2012-01-01

    Full Text Available Results of deep comprehensive investigation of possibility of a method of micellar colloidal synthesis for reception nanoparticles of silver with the set characteristics are evaluated. The production technology of fibrous covers with nanoparticles of silver is considered

  18. Classical radiological aspects of fibrous dysplasia; Aspectos radiologicos classicos da displasia fibrosa nas radiografias do cranio

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Norma Selma Santos; Moraes e Silva, Denise; Lederman, Henrique M. [Escola Paulista de Medicina, Sao Paulo, SP (Brazil)

    1996-07-01

    The authors, after a review of the literature, show the features of fibrous dysplasia in the skull through conventional radiology, depicting the most common and classics aspects of this disease and its differential diagnosis. (author) 6 refs., 4 figs.

  19. Recurrent gingival fibrous lesions: comparison of 2 cases and potential need for additional classification.

    Science.gov (United States)

    Shumway, Brian S; Eskan, Mehmet Akif; Bernstein, Mark L

    2013-10-01

    Historically, the classification of localized gingival fibrous lesions has been inconsistent, leading to multiple naming schemes and confusion among pathologists. Currently, lesions are broadly grouped into localized hyperplastic lesions and true neoplasms. Although some cases are clearly defined histologically (i.e., peripheral ossifying fibroma, peripheral odontogenic fibroma), another set of "reactive" fibrous lesions exhibit overlapping histologic features including nondistinctive fibrosis and inflammation. This group can exhibit recurrence, classically related to a local stimulus. However, when local factors are absent, recurrence suggests inherent neoplastic potential. Herein, we describe 2 recurrent fibrous gingival masses, one of which reportedly recurred 3 times with no obvious inciting agent. The histologic appearance of both lesions was similarly distinctive but not well classifiable, while the immunohistochemical profile indicated divergent lesions. This highlights the need for further study of recurrent gingival fibrous lesions to better predict independent growth potential. PMID:23582456

  20. Assessment of fibrous insulation materials for the selenide isotope generator system

    International Nuclear Information System (INIS)

    Fibrous insulations for use in the converter and the heat source of the radioisotope-powered, selenide element, thermoelectric generator (selenide isotope generator) are assessed. The most recent system design and material selection basis is presented. Several fibrous insulation materials which have the potential for use as load-bearing or nonload-bearing thermal insulations are reviewed, and thermophysical properties supplied by manufacturers or published in the literature are presented. Potential problems with the application of fibrous insulations in the selenide isotope generator are as follows: compatibility with graphite, the thermoelectric elements, and the isolation hot frame; devitrification, grain growth, and sintering with an accompanying degradation of insulation quality; impurity diffusion from the insulation to adjoining structures; outgassing and storage of fibrous materials. Areas in which thermophysical data or quantitative information on the insulation and structural stability is lacking are identified

  1. The diagnostic role of nuclear medicine in haematological malignancies

    International Nuclear Information System (INIS)

    Lymphomas are malignancies of the haematological system and normally originate and disseminate through the lymphatic system. Radionuclide methods have been in use for the past several decades in the management of lymphoma. Initially lymphoscintigraphy was used for identifying lymph node involvement in lymphoma. However the advent of CT and MRI saw lymphoscintigraphy relegated to the side line. Subsequently, the recognition of post therapy residual mass of fibrous tissue, looking like lymphoma on CT and MRI has lead to a resurgent interest in the functional nuclear medicine diagnostic procedures, especially imaging with Ga-67 citrate and Tc-99m MIBI. Whilst these could be used in a small number of difficult patients, often post therapy; the advent of F-18 FDG PET has lead to an overwhelming increase in the use of radionuclide techniques. Positron emission tomography (PET) is a novel functional imaging technique that can use a glucose analog (2-fluoro-2-deoxy-D-glucose [FDG]) radiolabeled with the positron emitter fluorine-18 to evaluate glycolytic activity, which is greater in malignancies, including lymphoma. Several studies have suggested a role for FDG-PET in the diagnosis and followup of patients with lymphoma, and it is rapidly becoming a standard procedure for lymphoma management. PET provides several inherent advantages over other nuclear imaging techniques. The short half-life of FDG allows patient convenience and improved imaging characteristics. With modern dedicated PET machines, a resolution of approximately 5 mm can be achieved, and the ability to co-register PET with anatomic computerized tomography (CT) imaging allows for ease of interpretation. Moreover, using a quantitative approach to interpretation with the standardized uptake value (SUV) (ratio of activity per volume unit over injected activity per body mass), PET imaging appears to be more precise than conventional scintigraphy and is rapidly becoming an essential part in the management of lymphoma. (author)

  2. Filtration efficiency of an electrostatic fibrous filter: Studying filtration dependency on ultrafine particle exposure and composition

    DEFF Research Database (Denmark)

    Ardkapan, Siamak Rahimi; Johnson, Matthew S.; Yazdi, Sadegh; Afshari, Alireza; Bergsøe, Niels C.

    2014-01-01

    The objective of the present study is to investigate the relationship between ultrafine particle concentrations and removal efficiencies for an electrostatic fibrous filter in a laboratory environment. Electrostatic fibrous filters capture particles efficiently, with a low pressure drop. Therefore they have applications in building ventilation systems. The relationship between particle removal efficiency and particle concentration has not been widely investigated in ventilation systems and indoo...

  3. Measurement of fibrous cap thickness in atherosclerotic plaques by spatiotemporal analysis of laser speckle images

    OpenAIRE

    Nadkarni, Seemantini K.; Bilenca, Alberto; Bouma, Brett E.; Tearney, Guillermo J.

    2006-01-01

    Necrotic-core fibroatheromas (NCFA) with thin, mechanically weak fibrous caps overlying lipid cores comprise the majority of plaques that rupture and cause acute myocardial infarction. Laser speckle imaging (LSI) has been recently demonstrated to enable atherosclerotic plaque characterization with high accuracy. We investigate spatio-temporal analysis of LSI data, in conjunction with diffusion theory and Monte Carlo modeling of light transport, to estimate fibrous cap thickness in NCFAs. Time...

  4. Role of bioactive 3D hybrid fibrous scaffolds on mechanical behavior and spatiotemporal osteoblast gene expression.

    Science.gov (United States)

    Allo, Bedilu A; Lin, Shigang; Mequanint, Kibret; Rizkalla, Amin S

    2013-08-14

    Three-dimensional (3D) bioactive organic-inorganic (O/I) hybrid fibrous scaffolds are attractive extracellular matrix (ECM) surrogates for bone tissue engineering. With the aim of regulating osteoblast gene expression in 3D, a new class of hybrid fibrous scaffolds with two distinct fiber diameters (260 and 600 nm) and excellent physico-mechanical properties were fabricated from tertiary (SiO2-CaO-P2O5) bioactive glass (BG) and poly (?-caprolactone) (PCL) by in situ sol-gel and electrospinning process. The PCL/BG hybrid fibrous scaffolds exhibited accelerated wetting properties, enhanced pore sizes and porosity, and superior mechanical properties that were dependent on fiber diameter. Contrary to control PCL fibrous scaffolds that were devoid of bonelike apatite particles, incubating PCL/BG hybrid fibrous scaffolds in simulated body fluid (SBF) revealed bonelike apatite deposition. Osteoblast cells cultured on PCL/BG hybrid fibrous scaffolds spread with multiple attachments and actively proliferated suggesting that the low temperature in situ sol-gel and electrospinning process did not have a detrimental effect. Targeted bone-associated gene expressions by rat calvarial osteoblasts seeded on these hybrid scaffolds demonstrated remarkable spatiotemporal gene activation. Transcriptional-level gene expressions for alkaline phosphatase (ALP), osteopontin (OPN), bone sialoprotein (BSP), and osteocalcin (OCN) were significantly higher on the hybrid fibrous scaffolds (p < 0.001) that were largely dependent on fiber diameter compared. Taken together, our results suggest that PCL/BG fibrous scaffolds may accelerate bone formation by providing a favorable microenvironment. PMID:23826710

  5. [The influence of "rigidity" and structure of fibrous dust on their biological activity].

    Science.gov (United States)

    Troitskaia, N A; Velichkovski?, B T; Vanchugova, N N

    2000-01-01

    The authors represent experimental data on cytotoxic, fibrogenic and mutagenic effects of fibrous dusts--"soft" pulp fibers and "stiff" ones (chrysotile-asbestos, carbon, basalt and fiber glass) in comparison with the nonfibrous analogs (antigorit, quartz DQ-12 and others). Viability of peritoneal macrophages was depressed more dramatically by "stiff" fibers vs. the "soft" ones. Mutagenic activity was associated with the "stiffness" degree of the dust particles. When compared to fibrous chemical dusts, nonfibrous ones appeared inert in micronuclear test. PMID:10826365

  6. Exploiting BSA to Inhibit the Fibrous Aggregation of Magnetic Nanoparticles under an Alternating Magnetic Field

    OpenAIRE

    Ning Gu; Yu Zhang,; Xuan Liu; Yuan Chen; Jian Fei Sun

    2013-01-01

    The alternating magnetic field was discovered to be capable of inducing the fibrous aggregation of magnetic nanoparticles. However, this anisotropic aggregation may be unfavorable for practical applications. Here, we reported that the adsorption of BSA (bovine serum albumin) on the surfaces of magnetic nanoparticles can effectively make the fibrous aggregation of ?-Fe2O3 nanoparticles turn into a more isotropic aggregation in the presence of the alternating magnetic field. Also, the heating c...

  7. Thoracic Outlet Syndrome Caused by Fibrous Dysplasia of the First Rib

    OpenAIRE

    Kemp, Clinton D; Rushing, Gregory D.; Rodic, Nemanja; McCarthy, Edward; Stephen C. Yang

    2012-01-01

    Fibrous dysplasia causing thoracic outlet syndrome is rare. A 41-year-old woman presented with neurogenic thoracic outlet syndrome with imaging that demonstrated a large tumor of her proximal left first rib. Transaxillary excision was unsuccessful due to involvement of the subclavian vasculature and brachial plexus. Subsequent posterolateral thoracotomy and resection of her first rib revealed fibrous dysplasia. Thoracotomy should be considered in these cases for optimal vascular control and i...

  8. NAB2-STAT6 fusion types account for clinicopathological variations in solitary fibrous tumors.

    Science.gov (United States)

    Tai, Hui-Chun; Chuang, I-Chieh; Chen, Tse-Ching; Li, Chien-Feng; Huang, Shih-Chiang; Kao, Yu-Chien; Lin, Po-Chun; Tsai, Jen-Wei; Lan, Jui; Yu, Shih-Chen; Yen, Shao-Lun; Jung, Shih-Ming; Liao, Kuan-Cho; Fang, Fu-Min; Huang, Hsuan-Ying

    2015-10-01

    Solitary fibrous tumor (SFT) is characterized by the inv12(q13q13)-derived NAB2-STAT6 fusion, which exhibits variable breakpoints and drives STAT6 nuclear expression. The implications of NAB2-STAT6 fusion variants in pathological features and clinical behavior remain to be characterized in a large cohort of SFTs. We investigated the clinicopathological correlates of this genetic hallmark and analyzed STAT6 immunoexpression in 28 intrathoracic, 37 extrathoracic, and 23 meningeal SFTs. These 88 tumors were designated as histologically nonmalignant in 75 cases and malignant in 13, including 1 dedifferentiated SFT. Eighty cases had formalin-fixed and/or fresh samples to extract assessable RNAs for RT-PCR assay, which revealed NAB2-STAT6 fusion variants comprising 12 types of junction breakpoints in 73 fusion-positive cases, with 65 (89%) falling into 3 major types. The predominant NAB2ex4-STAT6ex2 (n=33) showed constant breakpoints at the ends of involved exons, whereas the NAB2ex6-STAT6ex16 (n=16) and NAB2ex6-STAT6ex17 (n=16) might exhibit variable breakpoints and incorporate NAB2 or STAT6 intronic sequence. Including 73 fusion-positive and 7 CD34-negative SFTs, STAT6 distinctively labeled 87 (99%) SFTs in nuclei, exhibited diffuse reactivity in 73, but did not decorate 98 mimics tested. In seven fusion-negative cases, 6 were STAT6-positive, suggesting rare fusion variants not covered by RT-PCR assay. Regardless of histological subtypes, intrathoracic SFTs affected older patients (P=0.035) and tended to be larger in size (P=0.073). Compared with other variants, NAB2ex4-STAT6ex2/4 fusions were significantly predominant in the SFTs characterised by intrathoracic location (Pnuclear expression was distinctive in the vast majority of SFTs, including all fusion-positive tumors, and exploitable as a robust diagnostics of CD34-negative cases. Despite the associations of NAB2-STAT6 fusion variants with several clincopathological factors, their prognostic relevance should be further validated in large-scale prospective studies of SFTs. PMID:26226844

  9. Sperm protein 17 is expressed in the sperm fibrous sheath

    Directory of Open Access Journals (Sweden)

    Albani Elena

    2009-07-01

    Full Text Available Abstract Background Sperm protein 17 (Sp17 is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues. It was also recognized in two myeloma cell lines and in neoplastic cells from patients with multiple myeloma and ovarian carcinoma. These data all indicate that Sp17 is widely distributed in humans, expressed not only in germinal cells and in a variety of somatic tissues, but also in neoplastic cells of unrelated origin. Methods Sp17 expression was analyzed by immunocytochemistry and transmission electron microscopy on spermatozoa. Results Here, we demonstrate the ultrastructural localization of human Sp17 throughout the spermatozoa flagellar fibrous sheath, and its presence in spermatozoa during in vitro states from their ejaculation to the oocyte fertilization. Conclusion These findings suggest a possible role of Sp17 in regulating sperm maturation, capacitation, acrosomal reaction and interactions with the oocyte zona pellucida during the fertilization process. Further, the high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP-binding motif within this region, suggest that Sp17 might play a regulatory role in a protein kinase A-independent AKAP complex in both germinal and somatic cells.

  10. Nanoscale dynamics and aging of fibrous peptide-based gels

    Energy Technology Data Exchange (ETDEWEB)

    Dudukovic, Nikola A., E-mail: dudukov1@illinois.edu [Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States); Zukoski, Charles F. [Department of Chemical and Biological Engineering, University at Buffalo, Buffalo, New York 14222 (United States)

    2014-10-28

    Solutions of the aromatic dipeptide derivative molecule fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) in dimethyl sulfoxide produce fibrous gels when mixed with water. We study the evolution of density fluctuations of this three-component system using X-ray photon correlation spectroscopy (XPCS) and compare these results to the macroscopic rheology of the gels and optical observations of the microstructure evolution. At the investigated scattering angles, the intensity autocorrelation functions do not follow behavior expected for simple diffusion of individual Fmoc-FF molecules localized within cages of nearest neighbors. Instead, the dynamics are associated with density fluctuations on length scales of ?10–100 nm arising from disaggregation and reformation of fibers, leading to an increasingly uniform network. This process is correlated with the growth of the elastic modulus, which saturates at long times. Autocorrelation functions and relaxation times acquired from XPCS measurements are consistent with relaxation rates of structures at dynamic equilibrium. This study provides further support to the concept of exploring peptide-based gelators as valence-limited patchy particles capable of forming equilibrium gels.

  11. Fibrous adsorbent for removal of aqueous aromatic hydrocarbons.

    Science.gov (United States)

    Jung, Yong-Jun; Kiso, Yoshiaki; Oguchi, Tatsuo; Yamada, Toshiro; Takagi, Hiroo; Nishimura, Kazuyuki

    2007-01-01

    Bundles of a strongly hydrophobic fibrous material (p-phenylene-2,6-benzobisoxazole; PBO; Zylon) were employed as an adsorbent for the removal of aqueous aromatic compounds, because the PBO fibers are too rigid to be woven and did not entrap suspended solids. The removal performance for nine kinds of polyaromatic hydrocarbons (PAHs) and di-(2-ethylhexyl) phthalate (DEHP) was evaluated. PAHs and DEHP at initial concentrations of 50 microg L(-1) were removed at 72.5-99.9% and ca. 95%, respectively, although the removal efficiencies were affected by the phase ratio (fiber weight/solution volume). The logarithm of the partition coefficient (log K) for planar PAHs was linearly correlated with the logarithm of the n-octanol/water partition coefficient (log P), but nonplanar PAHs, such as cis-stilbene, p-terphenyl, and o-terphenyl, showed significantly lower adsorption performance. The adsorbed PAHs were not desorbed effectively with CH3CN, CH2Cl2, and toluene. On the other hand, DEHP was effectively desorbed with methanol. PMID:17585293

  12. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY; SEMIANNUAL

    International Nuclear Information System (INIS)

    During this reporting period, work continued on development of formulations using the materials identified as contenders for the fibrous monolith wear resistant components. The FM structures fabricated were: diamond/WC-Co, B(sub 4)C/WC-Co, TiB(sub 2)/WC-Co, WC-Co/Co, WC-Co/WC-Co. Results of our consolidation densification studies on these systems lead to the down-selection of WC-Co/WC-Co, WC-Co/Co and diamond/WC-Co for further development for mining applications including drill bit inserts, roof bit inserts, radial tools conical tools and wear plates (WC-Co based system only) for earth moving equipment. Prototype component fabrication focused on the fabrication of WC-Co/WC-Co FM conical tools, diamond/WC-Co coated drill bit insert prototypes. Fabrication of WC-Co/WC-Co FM insert prototypes for a grader blade is also underway. ACR plans to initiate field-testing of the drill bit insert prototypes and the grader blade insert this summer (2002). The first WC-Co/WC-Co FM conical tool prototypes were sent to Kennametal for evaluation towards the end of the current reporting period

  13. MALIGNANCY IN LARGE COLORECTAL LESIONS

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Oliveira dos SANTOS

    2014-09-01

    Full Text Available Context The size of colorectal lesions, besides a risk factor for malignancy, is a predictor for deeper invasion Objectives To evaluate the malignancy of colorectal lesions ?20 mm. Methods Between 2007 and 2011, 76 neoplasms ?20 mm in 70 patients were analyzed Results The mean age of the patients was 67.4 years, and 41 were women. Mean lesion size was 24.7 mm ± 6.2 mm (range: 20 to 50 mm. Half of the neoplasms were polypoid and the other half were non-polypoid. Forty-two (55.3% lesions were located in the left colon, and 34 in the right colon. There was a high prevalence of III L (39.5% and IV (53.9% pit patterns. There were 72 adenomas and 4 adenocarcinomas. Malignancy was observed in 5.3% of the lesions. Thirty-three lesions presented advanced histology (adenomas with high-grade dysplasia or early adenocarcinoma, with no difference in morphology and site. Only one lesion (1.3% invaded the submucosa. Lesions larger than 30 mm had advanced histology (P = 0.001. The primary treatment was endoscopic resection, and invasive carcinoma was referred to surgery. Recurrence rate was 10.6%. Conclusions Large colorectal neoplasms showed a low rate of malignancy. Endoscopic treatment is an effective therapy for these lesions.

  14. Cutaneous manifestations of internal malignancy

    Directory of Open Access Journals (Sweden)

    A Ayyamperumal

    2012-01-01

    Full Text Available Background: Many malignancies affecting the internal organs display cutaneous manifestations which may be either specific (tumor metastases or nonspecific lesions. Aims: The study is aimed at determining the frequency and significance of cutaneous manifestations among patients with internal malignancy. Materials and Methods: 750 cases of proven internal malignancy, who attended a cancer chemotherapy center in South India, were studied. Specific infiltrates were confirmed by histopathology, fine needle aspiration cytology (FNAC and marker studies. Results: Out of the 750 patients with internal malignancy, skin changes were seen in a total of 52 (6.93% patients. Conclusion: Cutaneous metastases (specific lesions were seen in 20 patients (2.66%: contiguous in 6 (0.8%, and non-contiguous in 14 (1.86%. Nonspecific skin changes were seen in 32 patients (4.26%. None of our patients presented with more than one type of skin lesions. Herpes zoster was the most common nonspecific lesion noticed in our patients, followed by generalized pruritus, multiple eruptive seborrheic keratoses, bullous disorder, erythroderma, flushing, purpura, pyoderma gangrenosum, insect bite allergy and lichenoid dermatitis.

  15. The Origin of Malignant Malaria

    Science.gov (United States)

    Plasmodium falciparum is the causative agent of malignant malaria, which is among the most severe human infectious diseases. Despite its overwhelming significance to human health, the parasite’s origins remain unclear. The favored origin hypothesis holds that P. falciparum and its closest known rel...

  16. Neuroleptic Malignant Syndrome: A Review

    OpenAIRE

    O'Brien, Richard A.; Young, G Bryan

    1989-01-01

    There has recently been interest in neuroleptic malignant syndrome (NMS) as the disorder has been better characterized. Nms is still poorly recognized, however, by most physicians. Hyperpyrexia, rigidity, altered consciousness, autonomic instability, and enzymatic evidence of muscle breakdown after drug intake are the cardinal features. The authors of this article review the proposed pathogenesis, complications, and treatment of NMS.

  17. Malignant transformation of uterine leiomyoma

    OpenAIRE

    Al Ansari, Afaf A.; Al Hail, Fatima A.; Abboud, Emad

    2013-01-01

    A rare case of malignant transformation of uterine leiomyoma is reported. A 54 year old lady, nulliparous and 2 years postmenopausal presented to gynecology clinic with a pelvi – abdominal mass and ultrasound scan suggestive of multiple uterine fibroid. Total abdominal hysterectomy performed. Histopathology report showed leiomyosarcomative changes from benign leiomyoma within the huge mass.

  18. Malignant nodular hidradenoma of scalp

    Directory of Open Access Journals (Sweden)

    Tanmoy Maiti

    2014-01-01

    Full Text Available Malignant nodular hidradenoma (MNH is a rare tumor of sweat gland known by many names in the literature. Scalp is a known and yet uncommon site of occurrence. We describe two patients with scalp MNH with brain parenchymal invasion. Both tumors recurred in spite of total excision and radiotherapy.

  19. Do We Know What Causes Malignant Mesothelioma?

    Science.gov (United States)

    ... Next Topic Can malignant mesothelioma be prevented? Do we know what causes malignant mesothelioma? Researchers have found ... genes – the instructions for how our cells function. We usually look like our parents because they are ...

  20. The computed tomographic findings of the primary retroperitoneal tumors

    International Nuclear Information System (INIS)

    The authors reviewed the CT findings of 31 cases of primary retroperitoneal tumors confirmed by operation (25 cases) or needle biopsy (6 cases) at the Chonnam University Hospital from June, 1983 to August, 1988. The size, shape, location, margin of mass, effect on the surrounding structures, presence or absence of metastasis and the composition of the tumor were analyzed to find the differential points between benign and malignant tumors and characteristic findings of each tumors. The results were as follows; 1. The benign tumor showed smaller size than malignant one and well circumscribed round or ovoid lesions, and no surrounding invasion or distant metastasis. 2. Some characteristic findings in teratoma, liposarcoma and malignant fibrous histiocytoma aided in differential diagnosis; 1) Teratoma showed mixture of fatty low density and high density, and characteristic fluid level. 2) Lipogenic liposarcoma showed fatty low density, slightly higher than that of normal retroperitoneal fat. 3) Malignant fibrous histiocytoma showed well margined mass with an attenuation coefficient equal or slightly lower than that of moral muscle and arose near kidney or adrenal gland and so compressed or invaded kidney

  1. MALIGNANT GROWTH MAXILLA MANAGEMENT AN ANALYSIS

    OpenAIRE

    Balasubramanian Thiagarajan; Geetha Ramamoorthy

    2013-01-01

    Malignant tumors involving maxilla is rather rare. This comprises about 1% of all malignant tumors seen in humans. This tumor constitutes roughly 3% of all head and neck malignancies. This article discusses our experience in managing patients with malignant tumors of maxilla. All our patients underwent total maxillectomy followed by post operative irradiation. Mean survival rates of our patients ranged from 2.5 years to 3 years. Survival rates were also dependent on the histology of the tumor...

  2. Malignant causes of fever of unknown origin.

    Science.gov (United States)

    Foggo, Vanessa; Cavenagh, Jamie

    2015-06-01

    The presence of fever in malignancy usually indicates infection, though transfusion, thrombosis and drugs are also culprits. However, particularly in some tumour types, fever can also be a paraneoplastic syndrome, caused by the malignancy itself. This can be a difficult diagnosis to establish and presents a therapeutic challenge to the physician when the underlying malignancy is not easily treated. PMID:26031983

  3. STRENGTH AND DEFORMABILITY OF STRUCTURAL ELEMENTS OF TRANSPORT FACILITIES ON THE BASIS OF FINE-GRAINED FIBROUS STEEL SLAG CONCRETE

    Directory of Open Access Journals (Sweden)

    R. N. Chernousov

    2011-11-01

    Full Text Available Problem statement. Application of steel fibrous concrete in structures of transport facilities providesfor their reliable and durable operation, however, along with the indisputable advantages,steel fibrous concrete has significant drawback. Its application in transport construction is very expensive.The use of cast slag crushed stone screenings, along with fibers from waste products oflocal factories, as a filler of concrete matrix will significantly reduce the costs of production oftransport facility structures and their elements with the use of steel fibrous concrete.Results and conclusions. According to the results of experimental studies formulae for practical estimationof shrinkage deformations of concrete matrix of fibrous steel slag concrete are obtained. Theanalytical relationships for fibrous steel slag concrete are derived. These relationships involve ultimatecompression and tensile strength, increase in compression and bending strength with time, longtermcompression strength, low cycle tensile fatigue, wearability. Based on experimental studies theuse of fibrous steel slag concrete in structural elements of transport facilities is suggested.

  4. [Investigation of fibrous cultural materials by infrared spectroscopy].

    Science.gov (United States)

    Luo, Xi-yun; Du, Yi-ping; Shen, Mei-hua; Zhang, Wen-qing; Zhou, Xin-guang; Fang, Shu-ying; Zhang, Xuan

    2015-01-01

    Cultural fibrous material includes both important categories, i. e. textile and paper, consisting of precious cultural materials in museum, such as costume, painting, and manuscript. In recent years more and more connoisseur and conservator's concerns are, through nondestructive method, the authenticity and the ageing identification of these cultural relics especially made from fragile materials. In this research, we used attenuated total reflection infrared spectroscopy to identify five traditional textile fibers, alongside cotton, linen, wool, mulberry silk and tussah silk, and another five paper fibers alongside straw, wheat straw, long qisong, Chinese alpine rush and mulberry bar, which are commonly used for making Chinese traditional xuan paper. The research result showed that the animal fiber (wool, mulberry silk and tussah silk) and plant fiber (cotton and linen) were easier to be distinguished by comparing the peaks at 3 280 cm-1 belonging to NH stretching vibration and a serious peaks related to amide I to amide III. In the spectrum of wool, the peak at 1 076 cm-1 was assigned to the S-O stretching vibration absorption of cystine in wool structure and can be used to tell wool from silk. The spectrum of mulberry silk and tussah silk seems somewhat difficult to be identified, as well as the spectrum of cotton and linen. Five rural paper fibers all have obvious characteristic peaks at 3 330, 2 900 cm-1 which are related to OH and CH stretching vibration. In the fingerprint wavenumber range of 1 600 - 800 cm, the similar peaks also appeared at 1 370, 1 320 cm-1 and 1 162, 1 050 cm-1, both group peaks respectively are related to CH and CO vibration in the structure of cellulose and hemicellulose in paper fibers. Although there is more similarity of the infrared spectroscopy of these 5 paper fibers, some tiny difference in absorbance also can be found at 3 300 cm-1 and in the fingerprint range at 1 332, 1 203, and 1 050 cm-1 which are related to C-O-C vibration in cellulose. Moreover, in order to explore direct and simple method to identify different materials with similar spectrum,. the principal component analysis (PCA) was applied to separate cotton and linen, mulberry silk and tussah silk, as well as five paper fibers. To eliminate and reduce the spectral scattering caused by sample uneven surface roughness, the multiplicative scatter correction (MSC) has been applied based on total spectral data. The result showed that the score plot using the first two principal components can effectively categorize both group textiles of cotton and linen, as well as mulberry silk and tussah silk, and they have similar chemical structure. For five paper fibers, the PCA was applied in different spectral range (918-550, 1 280-918, 1 700-1 280 and 3 800-2 800 cm-1), and the best result appeared in the range from 3 800 to 2 800 cm-1, in which the five paper fibers can be well categorized. This research showed that infrared spectroscopy combined with principal component analysis has great potential advantage on identifying fibrous materials with similar structure. PMID:25993821

  5. Analysis of progressive damage in fibrous composite laminates

    Energy Technology Data Exchange (ETDEWEB)

    Kaveh-Ahangar, A.

    1990-01-01

    A model of a cracked laminate which consisted of three layers of fibrous composite materials where the middle layer is a 90 degree ply and contains an infinite row of equally spaced transverse cracks and the outer layers have arbitrary fiber orientations was proposed to study the progressive transverse cracking phenomena in multi-layered laminates. It was assumed that a microcrack which resembles a slit crack exists in the ply undergoing cracking. The constructed admissible stress field in the tiplet at dilute crack density was utilized to calculate the energy release rate of the microcrack. The thickness of the ply undergoing cracking, fiber orientation, and thickness of its adjacent plies were included in the analysis. Then, linear elastic fracture mechanics was used to predict the strength of a typical ply. The residual thermal stresses were also included in the analysis. The classical laminated plate theory was used to calculate the complementary energy of the cracked triplet in terms of its unknown effective thermoelastic properties and those of its damaged middle layer. The complementary energy of the triplet was also calculated in terms of the local properties of each layer of the triplet, from the constructed admissible stress fields. After calculating the thermoelastic properties of the damaged triplet, the thermoelastic properties of the damaged middle layer of the triplet were extracted from the relations between them which was obtained through the classical laminated plate theory. The energy release rate of a microcrack in the ligament between two existing cracks was calculated based on the constructed admissible stress fields. The effect of the crack density in the ply undergoing progressive cracking, the location of the microcrack, and fiber orientation of the adjacent plies were included in the analysis.

  6. Vibration damage testing of thermal barrier fibrous blanket insulation

    International Nuclear Information System (INIS)

    GA Technologies is engaged in a long-term, multiphase program to determine the vibration characteristics of thermal barrier components leading to qualification of assemblies for High Temperature Gas-Cooled Reactor (HTGR) service. The phase of primary emphasis described herein is the third in a series of acoustic tests and uses as background the more elemental tests preceding it. Two sizes of thermal barrier coverplates with one fibrous blanket insulation type were tested in an acoustic environment at sound pressure levels up to 160 dB. Three tests were conducted using sinusoidal and random noise for up to 200 h duration at room temperature. Frequent inspections were made to determine the progression of degradation using definition of stages from a prior test program. Initially the insulation surface adjacent to the metallic seal sheets (noise side) assumed a chafed or polished appearance. This was followed by flattening of the as-received pillowed surface. This stage was followed by a depression being formed in the vicinity of the free edge of the coverplate. Next, loose powder from within the blanket and from fiber erosion accumulated in the depression. Prior experience showed that the next stage of deterioration exhibited a consolidation of the powder to form a local crust. In this test series, this last stage generally failed to materialize. Instead, surface holes generated by solid ceramic particulates (commonly referred to as 'shot') constituted the stage following powdering. With the exception of some manufacturing-induced anomalies, the final stage, namely, gross fiber breakup, did not occur. It is this last stage that must be prevented for the thermal barrier to maintain its integrity. (orig./GL)

  7. Giant cell tumour of peroneus brevis tendon sheath – a case report and review of literature

    Science.gov (United States)

    Goni, Vijay; Gopinathan, Nirmal Raj; Radotra, B D; Viswanathan, Vibhu Krishnan; Logithasan, Rajesh Kumar; S, Balaji

    2012-01-01

    Giant cell tumour of tendon sheath is a benign soft tissue lesion most commonly found in the flexor aspect of hand and wrist. Being rare in foot and ankle, the unusual presentation of this lesion may sometimes mimic other lesions like lipoma, synovial sarcoma, malignant fibrous histiocytoma, synovial cyst and ganglion. Hence it is important to include this lesion in differential diagnoses especially if the lesion is found to be anchored to any of the surrounding tendons. This article describes the unusual occurrence of giant cell tumour of the tendon sheath of peroneus brevis which is rarely described in literature. PMID:22802558

  8. Rhabdomyosarcomatous component in dedifferentiated chondrosarcoma.

    Science.gov (United States)

    Niezabitowski, A; Edel, G; Roessner, A; Grundmann, E; Timm, C; Wuisman, P

    1987-04-01

    The case of a 57-year-old male is described with an extended bone tumor in the proximal left femur. The tumor is histologically classified as dedifferentiated chondrosarcoma. Immunohistologic examination revealed a strong positive reaction for desmin mainly in the tumor giant cells in the dedifferentiated areas, whereas chondroblasts in the low grade chondrosarcoma areas reacted negatively with desmin. In accordance with some cross striation in polymorphic tumor cells this points to a rhabdomyosarcomatous component in the dedifferentiated portions of the tumors. Thus, in addition to fibrosarcomatous, osteosarcomatous and malignant fibrous histiocytoma-like areas, our case presents another sarcomatous constituent in dedifferentiated chondrosarcoma. PMID:3601806

  9. Clinically malignant atypical glomus tumour

    Science.gov (United States)

    Binesh, Fariba; Akhavan, Ali; Zahir, Shokouh Taghipour; Bovanlu, Taghi Roshan

    2013-01-01

    Glomus tumours (GTs) resemble the normal glomus body and have a predilection for skin and subcutaneous tissue. Although the majority of glomus tumours are small, benign neoplasms that occur in the dermis or subcutis of the extremities and cases of atypical or malignant variants have been reported. We report a case of a man who presented with a 1-year history of subcutaneous nodule in the right scapular area which was mildly tender. The nodule measured 2?cm. Microscopic examination showed features of glomus tumour with increased mitotic activity. These features, by current definition, would suggest glomus tumour of uncertain malignant potential. Three months later, he presented with recurrence. During his metastasis work-up, we noticed bilateral pulmonary metastasis. Metastasising GTs are rare. The patient underwent wide local excision and received chemotherapy. PMID:23291816

  10. Foramen magnum metastatic malignant melanoma

    Directory of Open Access Journals (Sweden)

    Pai S

    2003-01-01

    Full Text Available The foramen magnum as a site for brain metastasis is extremely rare. We report the case of a 24-year-old male who presented with features of increased intracranial pressure and lower cranial nerve palsies. Imaging revealed a foramen magnum tumor with extension up to the cerebellar vermis superiorly and into the spinal canal inferiorly (craniospinal mass with mild obstructive hydrocephalus. A malignant melanoma was completely excised. The patient continued to be tumor-free 24 months later.

  11. Limb Salvage in Malignant Tumors

    OpenAIRE

    Steinau, Hans-Ulrich; Daigeler, Adrien; Langer, Stefan; Steinsträsser, Lars; Hauser, Jörg; Goertz, Ole; Lehnhardt, Markus

    2010-01-01

    Limb-sparing resection and reconstruction has become the treatment of choice in extremity malignancies, as amputation does not provide better long-term survival rates or functional advantages. R0 resection, the removal of the tumor in sano, remains the prerequisite and most important oncologic parameter to avoid local recurrence. Successful treatment requires the combination of surgical eradication and the patient's specific functional and aesthetic rehabilitation. Our clinical rationale resu...

  12. CT triage for lung malignancy

    DEFF Research Database (Denmark)

    Kusk, Martin; Karstoft, Jens; Mussmann, Bo

    2015-01-01

    Background: Generation of multiplanar reformation (MPR) images has become automatic on most modern computed tomography (CT) scanners, potentially increasing the workload of the reporting radiologists. It is not always clear if this increases diagnostic performance in all clinical tasks. Purpose: To assess detection performance using only coronal multiplanar reformations (MPR) when triaging patients for lung malignancies with CT compared to images in three orthogonal planes, and to evaluate perfo...

  13. Clinical radiobiology of malignant melanoma

    DEFF Research Database (Denmark)

    Bentzen, Søren M; Overgaard, Jens; Thames, H D; Overgaard, Marie; Vejby Hansen, P; von der Maase, Hans; Meder, J

    1989-01-01

    Tumor-control probability (TCP) was analyzed in a series of 121 patients having 239 histologically proven recurrent or metastatic malignant melanomas. These were treated with fractionated radiotherapy with various doses per fraction, total doses, and overall times. Cutaneous lesions (127, 53%) were treated with electron beams, and more deeply seated tumors (112, 47%) with 60Co or 4-8 MV X-rays. The fraction size was highly variable, and this permitted determination of the alpha/beta ratio in the...

  14. PSYCHOLOGICAL ASPECTS OF HAEMATOLOGICAL MALIGNANCIES

    OpenAIRE

    Kulhara, P.; Verma, S. C.; Bambery, P; Nehra, R.

    1990-01-01

    Sixty nine patients with various types of haematological malignancies were studied. Chronic myeloid leukaemia (n =32) was the commonest diagnosis. The patients were assessed on Hamilton Rating Scale for Depression, PGI-N2 Health Questionnaire and Presumptive Stressful Life Events Scale and those who had scores above the cut off points for Hamilton Rating Scale and/or PGI-N2 Health Questionnaire were assessed on Present State Examination. The patients were followed up at 3 and 6 months interva...

  15. Amisulpride and Neuroleptic Malignant Syndrome

    OpenAIRE

    Ming-Che Tu; Cheng-Cheng Hsiao

    2011-01-01

    Neuroleptic malignant syndrome (NMS) is a rare but lethal complication of neuroleptics. Its incidence ranges between 0.02% and 3%. Amisulpride, a second generation neuroleptic, was associated with rhabdomyolysis in one report and NMS in 2 reports. Althoughthe precise pathogenesis is still unclear, dopamine receptor blockade is theorized to play acentral role. Conventional presentations include hyperthermia, muscle rigidity, and elevatedcreatine kinase concentrations. However, similar to other...

  16. Skin manifestations of internal malignancy.

    Science.gov (United States)

    Braverman, Irwin M

    2002-02-01

    This article concentrates on the major signs and syndromes that are associated with internal malignancies in the geriatric population. Included are cutaneous metastases, ectopic adrenocorticotropic hormone-producing syndromes, and disorders arising from APUD cell tumors. The major paraneoplastic disorders of dermatomyositis, generalized pruritus, Bazex's syndrome, and acanthosis nigricans also are discussed. Also included are Bowen's disease of skin; arsenical toxicity; and the Peutz-Jeghers', Gardner's, and Torre's syndromes, which are indicative of systemic or organ-related carcinogens. PMID:11913734

  17. Oncolytic poliovirus against malignant glioma

    OpenAIRE

    Goetz, Christian; Dobrikova, Elena; Shveygert, Mayya; Dobrikov, Mikhail; Gromeier, Matthias

    2011-01-01

    In cancerous cells, physiologically tight regulation of protein synthesis is lost, contributing to uncontrolled growth and proliferation. We describe a novel experimental cancer therapy approach based on genetically recombinant poliovirus that targets an intriguing aberration of translation control in malignancy. This strategy is based on the confluence of several factors enabling specific and efficacious cancer cell targeting. Poliovirus naturally targets the vast majority of ectodermal/neur...

  18. Malignant endobronchial lesions of adolescence

    International Nuclear Information System (INIS)

    Rare primary endobronchial malignancies were diagnosed in four adolescents: atypical bronchial carcinoid, mucoepidermoid carcinoma, bronchogenic (squamous cell) carcinoma, and non-Hodgkin's lymphoma. Metastatic disease was evident in each case. Three of the four patients died within one year of diagnosis. This paper describes each of these entities, illustrates their plain film and CT abnormalities (bronchial 'cut-off', hilar mass, local congestive edema, lobar collapse, hyperinflation), and discusses the utility of CT in their diagnosis. (orig.)

  19. Malignant endobronchial lesions of adolescence

    Energy Technology Data Exchange (ETDEWEB)

    Bellah, R.D. (Dept. of Radiology, Children' s Hospital of Philadelphia, PA (United States)); Mahboubi, S. (Dept. of Radiology, Children' s Hospital of Philadelphia, PA (United States)); Berdon, W.E. (Dept. of Radiology, Babies Hospital/Columbia Presbyterian Medical Center, New York, NY (United States))

    1992-12-01

    Rare primary endobronchial malignancies were diagnosed in four adolescents: atypical bronchial carcinoid, mucoepidermoid carcinoma, bronchogenic (squamous cell) carcinoma, and non-Hodgkin's lymphoma. Metastatic disease was evident in each case. Three of the four patients died within one year of diagnosis. This paper describes each of these entities, illustrates their plain film and CT abnormalities (bronchial 'cut-off', hilar mass, local congestive edema, lobar collapse, hyperinflation), and discusses the utility of CT in their diagnosis. (orig.)

  20. [Epigenetic therapy for hematologic malignancies].

    Science.gov (United States)

    Kobayashi, Yukio

    2015-10-01

    Cumulative evidence suggests that at least some hematologic malignancies are derived from alterations of epigenetic machinery. Next generation sequencing has revealed recurrent mutations of genes related to DNA methylation and histone modification in myelodysplastic syndromes (MDS), acute myeloid leukemia, malignant lymphoma, and multiple myeloma. Both these pathways are targetable and specific inhibitors of their related proteins are currently in development. Among these novel therapies, hypomethylating agents have been approved for MDS, and recently, histone deacetylase inhibitors became available for T-cell lymphoma and multiple myeloma. Agents currently undergoing clinical trials include inhibitors of IDH2 targeting DNA methylation, and EZH2, Dot1L, and BRD4 inhibitors designed to target either writers or readers of post-translational modifications (PTMs) of histones. In a phase I setting, where the maximum tolerated dose has not been reached, efficacy was reported with these agents. Furthermore, Dot1bL and IDH2 inhibitors have been shown to induce differentiation of leukemic blasts in patients with MLL gene rearrangements and IDH2 mutations, respectively, thus providing functional evidence supporting the use of inhibitors of epigenetic mechanisms as a means of differentiation therapy for hematologic malignancies. PMID:26458440

  1. Temozolomide for Treating Malignant Melanoma.

    Science.gov (United States)

    Li, Rong-Hua; Hou, Xiao-Yang; Yang, Chun-Sheng; Liu, Wen-Lou; Tang, Jian-Qin; Liu, Yan-Qun; Jiang, Guan

    2015-09-01

    Melanoma is one of the most malignant forms of skin cancer; with a rapidly increasing prevalence. Early-stage melanoma is curable, but advanced metastatic melanoma is almost always fatal, and patients with such advanced disease have short median survival. Surgery and radiotherapy play a limited role in the treatment of metastatic melanoma. Rather, chemotherapy remains the mainstay of treatment, although other approaches, including biotherapy and gene therapy, have been attempted. The authors hereby, evaluated the use of temozolomide (TMZ) for treating metastatic melanoma compared to dacarbazine (DTIC), the effectiveness of TMZ for treating brain metastases, as well as TMZ resistance and how the efficacy of TMZ in malignant melanoma can be increased. Two chemotherapeutic regimens are commonly used for palliative treatment of malignant melanoma: intravenous administration of DTIC and oral administration of the alkylating agent temozolomide (TMZ). Compared to DTIC, TMZ is very well tolerated and has an advantage in terms of improving the quality of life of patients with metastatic melanoma. While the prognosis is currently unpromising, chemotherapy plays a palliative role for patients with metastatic melanoma. The toxicity of treatment regimens based on DTIC and TMZ do not differ significantly, although TMZ is costlier. These findings provide a reference for future researchers via a comprehensive analysis of the relevant literature. PMID:26374366

  2. Malignant tumours of the vulva

    International Nuclear Information System (INIS)

    The thesis analyses 317 patients with vulvar malignancies treated at the University Hospital, Lund, during 1960-1979. The three most common histological types of malignancy have been analysed. The oncological clinic in Lund has since the 1960's used a surgical technique where the primary tumour and the regional lymph nodes are operated on in two separate surgical seances. The vulvectomy is performed with tarm knife technique, and the wound is left open. The 5-year crude survival rate for the entire patient material treated with curative intention was over 60 %, which agrees well with reports from other centres. Our surgical approach using two separate seances has, however, much lower rates of postoperative complications and mortality than the rates in other reports. The overall most important prognostic factors for the patients with invasive vulvar malignancies are the presence of lymphatic metastases at the time of surgery, and the surgical radicality of the primary surgery. The treatment at most stages of tumour development and most histological types should include total vulvectomy preoperative irradiation of the inguinal lymph nodes, and inguinal lymphadenectomy. Only local extirpation and hemivulvectomy are, however, indicated for small microinvasively growing squamous cell carcinoma and basal cell carcinoma. Samll invasive onesided squamous cell carcinoma is best treated with ipsilateral surgery combined with preoperative irradiation of the inguinal lymph nodes. Patients with metastases in the inguinal lymph nodes should receive additional irradiation of the inguinal and pelvic lymph node stations. (Author)

  3. MR imaging of liver cirrhosis. Role of fibrous septa in visualization of regenerating nodules

    International Nuclear Information System (INIS)

    The objective of this study was to identify the factors affecting the visualization of regenerating nodules in cirrhotic liver by MR imaging. MR images from patients with liver cirrhosis and normal subjects were studied, and signal intensity within the liver was measured and correlated with histologic findings. A reference phantom was also used as a standard. The signal intensity of the liver on T2-weighted (T2WI) spin-echo (SE) images was significantly increased in patients with liver cirrhosis. Multiple ring-like or reticular high-intensity areas (RHAs) were demonstrated on T2WI SE images in 44 of 125 cirrhotic livers. Histologic examination in 44 cases revealed various degrees of inflammatory changes in fibrous septa surrounding regenerative nodules in all specimens, vascular dilation in fibrous septa in 4 specimens, and no hemosiderin deposition in some specimens. The results of linear discriminant analysis showed that inflammatory changes in fibrous septa were significantly more pronounced in cases with RHAs on MR. RHAs seen on T2WI SE images may correspond to fibrous septa with inflammation. The signal intensity of fibrous septa surrounding regenerative nodules on T2WI SE images may be increased in liver cirrhosis due to inflammation or vascular dilation, contributing to the visualization of regenerating nodules as relatively low-intensity regions on MR. (orig.)

  4. Adsorption kinetics and isotherms of zeolite coatings directly crystallized on fibrous plates for heat pump applications

    International Nuclear Information System (INIS)

    Zeolite A coatings were grown on porous fibrous metal plates by using the substrate heating synthesis method. The coatings prepared were characterized by X-ray diffraction (XRD) and laser microscopy. Kinetic measurements were performed to determine the rates of adsorption of these materials while their adsorption isotherms were obtained by thermogravimetry (TG). The overall adsorption kinetics varied with the different samples investigated. The zeolite A coating grown on a copper fibrous support generally exhibited superior overall adsorption kinetics compared to a zeolite X coating with close mass, prepared previously on a stainless steel flat plate. The coating thickness as well as the support properties affected the performances of the samples. The inclusion of an additional polymer layer exhibited adverse impact on the kinetics especially after relatively high normalized loadings. The adsorption isotherms obtained for the zeolite coatings on fibrous supports were quite typical for zeolite A while the addition of polymer changed the isotherm type. -- Highlights: • Thick zeolite A coatings were grown on fibrous metal plates. • Use of fibrous supports improved heat transfer quality. • Coating thickness influenced adsorption kinetics notably. • Inclusion of an additional polymer layer changed kinetics and isotherm type

  5. Experimental investigation of sedimentation of LOCA - generated fibrous debris and sludge in BWR suppression pools

    International Nuclear Information System (INIS)

    Several tests were conducted in a 1:2.4 scale model of a Mark I suppression pool to investigate the behavior of fibrous insulation and sludge debris under LOCA conditions. NUKON trademark shreds, manually cut and tore up in a leaf shredder, and iron oxide particles were used to simulate fibrous and sludge debris, respectively. The suppression pool model included four downcomers fitted with pistons to simulate the steam-water oscillations during chugging expected during a LOCA. The study was conducted to provide debris settling velocity data for the models used in the BLOCKAGE computer code, developed to estimate the ECCS pump head loss due to clogging of the strainers with LOCA generated debris. The tests showed that the debris, both fibrous and particulate, remains fully mixed during chugging; they also showed that, during chugging, the fibrous debris underwent fragmentation into smaller sizes, including individual fibers. Measured concentrations showed that fibrous debris settled slower than the sludge, and that the settling behavior of each material is independent of the presence of the other material. Finally, these tests showed that the assumption of considering uniform debris concentration during strainer calculations is reasonable. The tests did not consider the effects of the operation of the ECCS on the transport of debris in the suppression pool

  6. Non-oxidative and oxidative torrefaction characterization and SEM observations of fibrous and ligneous biomass

    International Nuclear Information System (INIS)

    Highlights: • Non-oxidative and oxidative torrefaction of biomass is studied. • Two fibrous biomasses and two ligneous biomasses are tested. • SEM observations of four biomasses are provided. • Fibrous biomass is more sensitive to O2 concentration than ligneous biomass. • The performance of non-oxidative torrefaction is better than that of oxidative torrefaction. - Abstract: Oxidative torrefaction is a method to reduce the operating cost of upgrading biomass. To understand the potential of oxidative torrefaction and its impact on the internal structure of biomass, non-oxidative and oxidative torrefaction of two fibrous biomass materials (oil palm fiber and coconut fiber) and two ligneous ones (eucalyptus and Cryptomeria japonica) at 300 °C for 1 h are studied and compared with each other. Scanning electron microscope (SEM) observations are also performed to explore the impact of torrefaction atmosphere on the lignocellulosic structure of biomass. The results indicate that the fibrous biomass is more sensitive to O2 concentration than the ligneous biomass. In oxidative torrefaction, an increase in O2 concentration decreases the solid yield. The energy yield is linearly proportional to the solid yield, which is opposite to the behavior of non-oxidative torrefaction. The performance of non-oxidative torrefaction is better than that of oxidative torrefaction. As a whole, ligneous biomass can be torrefied in oxidative environments at lower O2 concentrations, whereas fibrous biomass is more suitable for non-oxidative torrefaction

  7. Evaluation of sodium sulfite and protein correction in analyses of fibrous compounds in tropical forages

    Scientific Electronic Library Online (English)

    Daiany Íris, Gomes; Edenio, Detmann; Sebastião de Campos, Valadares Filho; Rafael, Mezzomo; Natália Krish de Paiva, Souza; Augusto César de, Queiroz; Kelly da Silva Coutinho, Detmann.

    2012-01-01

    Full Text Available The objective of this study was to evaluate the contents of fibrous compounds in tropical grasses and legumes according to utilization of sodium sulfite in the neutral detergent solution or using a procedure for contaminant protein correction. Samples of ten grasses and ten legumes were used. The co [...] ntents of neutral detergent fiber were decreased when sodium sulfite was used; however, more prominent reductions were verified in legumes. Sodium sulfite decreased the acid detergent fiber content in both forage groups. The contents of neutral and acid detergent insoluble protein and lignin were reduced by sodium sulfite in legumes, but no effect was observed in grasses with regard to these variables. The decrease in fiber contents in legumes could be explained by the solubilization of lignin and decrease in insoluble nitrogen. However, the decreases in fiber in grasses could not be solely explained by the decrease in contaminant protein and solubilization of lignin, and loss of other fibrous compounds probably occurred. The utilization of sodium sulfite compromises the accuracy of the estimates of fibrous compounds contents in tropical forages. The precision of the estimates were not relevantly increased by sodium sulfite. The correction of insoluble fibrous compounds for protein is suggested instead of using sodium sulfite because there are no modifications on neutral detergent solution or undesirable solubilization of fibrous compounds.

  8. IMMUNE RESPONSE IN MALIGNANT GLIOMA

    Directory of Open Access Journals (Sweden)

    Iliyan Koev

    2010-07-01

    Full Text Available Objective: Malignant gliomas are primary brain tumors with excessive mortality and high resistance to chemotherapy and radiotherapy. The survival time for glioblastoma multi­forme is about 6-12 months. As key pathogenetic mechanisms are recognized the massive necrosis, angiogenesis and hypoxia within the tumor, as well as the resistance to apoptosis. It is also suspected that altered immune response might contribute to the fatal clinical outcome.The aim of the present study was to determine the immune status of patients with malignant gliomas.Material and methods: Peripheral blood lymphocytes were collected preoperatively from 9 patients (aged 57-76 diagnosed as anaplastic astrocytoma grade III (n=4 and glioblastoma multiforme (n=5. The following lymphocyte populations were analyzed by flow cytometry: CD19+, CD3+, CD3+CD4+, CD3+CD8+, CD3-CD56+, CD3+CD56+, CD3+CD25+, CD8-CD11b+, CD8+CD11b+, CD8+CD11b-. The results obtained were compared to reference values for each cell population.Results: No significant alterations were detected in CD19+, CD3+, CD3+CD4+, CD3+CD8+ cells, but the CD4/CD8 ratio was below the reference range in some cases. No obvious decrease in (CD3-CD56+ NK cells and (CD3-CD56+ NKT cells was observed in most patients. A reproducible phenomenon of increased CD8+CD11b+ and decreased CD8+CD11b- cells was noticed. These preliminary results suggest that the immune response in patients with malignant glioma is seriously disregulated. The rapid clinical deterioration, relapses and high mortality could be at least partially explained with the suppressed activity of NK-cells which are the major cytotoxic antitumoral cells. The increase in the population of activated suppressor-effector cells also contributes to the unfavourable outcome in malignant brain tumors.Conclusion: This pilot study reveals the presence of altered immune response in malignant gliomas and opens possibilities for prospective investigations concerning immune status and clinical outcome.

  9. Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors

    Directory of Open Access Journals (Sweden)

    Griffiths Gary L

    2009-06-01

    Full Text Available Abstract Background The existence of large pores in the blood-tumor barrier (BTB of malignant solid tumor microvasculature makes the blood-tumor barrier more permeable to macromolecules than the endothelial barrier of most normal tissue microvasculature. The BTB of malignant solid tumors growing outside the brain, in peripheral tissues, is more permeable than that of similar tumors growing inside the brain. This has been previously attributed to the larger anatomic sizes of the pores within the BTB of peripheral tumors. Since in the physiological state in vivo a fibrous glycocalyx layer coats the pores of the BTB, it is possible that the effective physiologic pore size in the BTB of brain tumors and peripheral tumors is similar. If this were the case, then the higher permeability of the BTB of peripheral tumor would be attributable to the presence of a greater number of pores in the BTB of peripheral tumors. In this study, we probed in vivo the upper limit of pore size in the BTB of rodent malignant gliomas grown inside the brain, the orthotopic site, as well as outside the brain in temporalis skeletal muscle, the ectopic site. Methods Generation 5 (G5 through generation 8 (G8 polyamidoamine dendrimers were labeled with gadolinium (Gd-diethyltriaminepentaacetic acid, an anionic MRI contrast agent. The respective Gd-dendrimer generations were visualized in vitro by scanning transmission electron microscopy. Following intravenous infusion of the respective Gd-dendrimer generations (Gd-G5, N = 6; Gd-G6, N = 6; Gd-G7, N = 5; Gd-G8, N = 5 the blood and tumor tissue pharmacokinetics of the Gd-dendrimer generations were visualized in vivo over 600 to 700 minutes by dynamic contrast-enhanced MRI. One additional animal was imaged in each Gd-dendrimer generation group for 175 minutes under continuous anesthesia for the creation of voxel-by-voxel Gd concentration maps. Results The estimated diameters of Gd-G7 dendrimers were 11 ± 1 nm and those of Gd-G8 dendrimers were 13 ± 1 nm. The BTB of ectopic RG-2 gliomas was more permeable than the BTB of orthotopic RG-2 gliomas to all Gd-dendrimer generations except for Gd-G8. The BTB of both ectopic RG-2 gliomas and orthotopic RG-2 gliomas was not permeable to Gd-G8 dendrimers. Conclusion The physiologic upper limit of pore size in the BTB of malignant solid tumor microvasculature is approximately 12 nanometers. In the physiologic state in vivo the luminal fibrous glycocalyx of the BTB of malignant brain tumor and peripheral tumors is the primary impediment to the effective transvascular transport of particles across the BTB of malignant solid tumor microvasculature independent of tumor host site. The higher permeability of malignant peripheral tumor microvasculature to macromolecules smaller than approximately 12 nm in diameter is attributable to the presence of a greater number of pores underlying the glycocalyx of the BTB of malignant peripheral tumor microvasculature.

  10. Mechanism of FGF23 processing in fibrous dysplasia.

    Science.gov (United States)

    Bhattacharyya, Nisan; Wiench, Malgorzata; Dumitrescu, Claudia; Connolly, Brian M; Bugge, Thomas H; Patel, Himatkumar V; Gafni, Rachel I; Cherman, Natasha; Cho, Monique; Hager, Gordon L; Collins, Michael T

    2012-05-01

    Fibroblast growth factor-23 (FGF23) is a phosphate- and vitamin D-regulating hormone derived from osteoblasts/osteocytes that circulates in both active (intact, iFGF23) and inactive (C-terminal, cFGF23) forms. O-glycosylation by O-glycosyl transferase N-acetylgalactosaminyltransferase 3 (ppGalNAcT3) and differential cleavage by furin have been shown to be involved in regulating the ratio of active to inactive FGF23. Elevated iFGF23 levels are observed in a number of hypophosphatemic disorders, such as X-linked, autosomal recessive, and autosomal dominant hypophosphatemic rickets, whereas low iFGF23 levels are found in the hyperphosphatemic disorder familial tumoral calcinosis/hyperphosphatemic hyperostosis syndrome. Fibrous dysplasia of bone (FD) is associated with increased total FGF23 levels (cFGF23?+?iFGF23); however, classic hypophosphatemic rickets is uncommon. Our results suggest that it can be explained by increased FGF23 cleavage leading to an increase in inactive cFGF23 relative to active iFGF23. Given the fact that FD is caused by activating mutations in the small G-protein G(s) ? that results in increased cyclic adenosine monophosphate (cAMP) levels, we postulated that there may be altered FGF23 cleavage in FD and that the mechanism may involve alterations in cAMP levels and ppGalNacT3 and furin activities. Analysis of blood specimens from patients with FD confirmed that the elevated total FGF23 levels are the result of proportionally increased cFGF23 levels, consistent with less glycosylation and enhanced cleavage by furin. Analysis of primary cell lines of normal and mutation-harboring bone marrow stromal cells (BMSCs) from patients with FD demonstrated that BMSCs harboring the causative G(s) ? mutation had higher cAMP levels, lower ppGalNAcT3, and higher furin activity. These data support the model wherein glycosylation by ppGalNAcT3 inhibits FGF23 cleavage by furin and suggest that FGF23 processing is a regulated process that controls overall FGF23 activity in FD patients. PMID:22247037

  11. Nutritional fibrous osteodystrophy in goats / Osteodistrofia fibrosa nutricional em caprinos

    Scientific Electronic Library Online (English)

    Paulo M, Bandarra; Saulo P, Pavarini; Adriana S, Santos; Nadia Aline B, Antoniassi; Cláudio E.F, Cruz; David, Driemeier.

    2011-10-01

    Full Text Available Sete de um total de 25 caprinos jovens (menos de um ano de idade) de um rebanho no sul do Brasil desenvolveram osteodistrofia fibrosa nutricional. Os animais afetados eram confinados em baias e alimentados com concentrado, cuja relação Ca:P era 1:6. O restante do rebanho (35 cabras) era mantido na p [...] astagem e não desenvolveu a doença. Os sinais clínicos se caracterizaram por aumento de volume da mandibula e maxila, vários graus de abertura de boca com protrusão da língua, em associação com dispneia e anormalidades de apreensão de alimento e mastigação. Os animais afetados apresentaram os níveis séricos de fósforo e paratormônio aumentados, bem como maior atividade de fosfatase alcalina. Três caprinos foram necropsiados e os achados de necropsia incluíram aumento bilateral da maxi-la e mandíbula, dentes frouxos, além de múltiplas fraturas incompletas de costelas em um caprino. Microscopicamente, havia intensa proliferação de tecido conjuntivo frouxo ao redor de trabéculas ósseas, muitas das quais estavam parcial ou completamente não mineralizadas. Trabéculas ósseas mineralizadas apresentaram osteoclastos em lacunas de Howship. Abstract in english Seven out of 25 goats from a southern Brazilian flock developed nutritional fibrous osteodystrophy. Affected animals were younger than 1 year of age and were confined in stalls and fed a concentrate ration containing 1:6 calcium:phosphorus ratio. The remaining flock (35 goats) was managed at pasture [...] and showed no disease. Clinical signs were characterized by mandibular and maxillary enlargements, varying degrees of mouth opening and protruding tongue, dyspnea, apart of abnormalities of prehension and mastication. Affected animals had increased seric levels of phosphorus and parathormone, as well as higher alkaline phosphatase activity. Postmortem examination on three succumbed goats revealed bilateral enlargement of the maxilla and mandibula, and loose teeth, apart of multiple incomplete rib fractures in one of them. Severe diffuse proliferation of loose connective tissue surrounded the osteoid trabeculae, many of which were partially or completely non-mineralized. Mineralized osteoid trabeculae showed osteoclasts in the Howship's lacunae.

  12. Self-assembly studies of native and recombinant fibrous proteins

    Science.gov (United States)

    Wilson, Donna Lucille

    The structure of silk proteins consists of alternating amorphous (glycine-rich) and ordered crystalline regions (poly(alanine) and poly(glycine-alanine) repeats), where the organized regions are typically beta-sheet assemblies. In collagen, the basic helical repeat (glycine-proline-hydroxyproline and variants on this repeat) drives hierarchical assembly. Three polypeptide chains form left-handed poly-proline II-like helices, these three chains then self-assemble to form a right-handed triple helix. The focus of this thesis is on these proteins and defined variations thereof to reveal features of fibrous protein self-assembly. The amino acid sequences of native silk and collagen and their respective assembly environments have been systematically manipulated. Spider silk protein, based on the consensus sequence of Nephila clavipes dragline-silk, was genetically engineered to include methionines flanking the beta-sheet forming polyalanine regions. These methionines could be selectively oxidized and reduced, altering the bulkiness and charge of a methionine-based sulfoxide group to control beta-sheet formation by steric hindrance. A second version of the sterical trigger included a recognition site for Protein Kinase A allowing for the selective phosphorylation of a serine. Patterning a monolayer of precursor "director" molecules on length scales ranging from nanometer- to micrometer-length scales simplifies the interpretation of supramolecular assembly. Utilizing the atomic force microscopy (AFM)-based technique of dip-pen nanolithography, thiolated collagen and a collagen-like peptide were patterned at 30--50 nm line widths on evaporated gold surfaces. These are the largest molecules thus far positively printed on a surface at such small-length scales. The method preserved the triple helical structure and biological activity of collagen and even fostered the formation of characteristic higher-levels of structural organization. Nanopatterns were also achieved for unmodified silk protein. A sequence block from the native primary structure of collagen IV, as well as sequences of selected collagen-modifying enzymes, were manipulated through recombinant DNA technology. Collagen IV is found primarily in the basement membrane of cells and typically characterized by a loose "chicken-mesh" network of individual molecules assembled via their end regions. (Abstract shortened by UMI.)

  13. Meningeal metastasing of malignant melanomas. Meningeale Metastasierung maligner Melanome

    Energy Technology Data Exchange (ETDEWEB)

    Gogoll, M.; Langer, M.; Hosten, N. (Klinikum Rudolf Virchow, Berlin (Germany, F.R.). Radiologische Klinik und Poliklinik)

    1989-08-01

    Two woman patients with malignant melanoma of the skin known from their case history and with acutely emerging neurological symptoms were examined both by CT and by MR tomography (both plain and with intravenous contrast medium). The radiologically derived suspicion of meningioma could not be confirmed by intraoperatively performed histological examination. In both cases the patients had meningeal melanoma metastases with low melanin content and without noticeable bleeding into the metastases. MR diagnosis is rendered difficult by the absence of paramagnetic substances typical of melanoma metastases. Hence, if the case history is known, it should be considered whether there is meningeal metastasising with atypical histology. (orig.).

  14. Solitary fibrous tumor of the male breast: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Sessa Fausto

    2008-02-01

    Full Text Available Abstract Extrapleural solitary fibrous tumors are very rare and occasionally they appear in extraserosal soft tissues or parenchymatous organs. In such cases the right preoperative diagnosis is often difficult and challenging, because both radiological and cytological examinations are not exhaustive. For these reasons, surgical excision is frequently the only way to reach the correct diagnosis and to achieve definitive treatment. A few cases of solitary fibrous tumors have been also described in the breast. Although rare, this lesion opens difficulties in preoperative diagnosis entering in differential diagnosis with other benign lesions as well as with breast cancer. In this article we describe a case of a solitary fibrous tumor of the breast in a 49-year-old man. Problems related to differential diagnosis and the possible pitfalls that can be encountered in the diagnostic iter of such rare tumor are discussed.

  15. Superhydrophobic coating to delay drug release from drug-loaded electrospun fibrous materials

    Science.gov (United States)

    Song, Botao; Xu, Shichen; Shi, Suqing; Jia, Pengxiang; Xu, Qing; Hu, Gaoli; Zhang, Hongxin; Wang, Cuiyu

    2015-12-01

    The drug-loaded electrospun fibrous materials showed attractive applications in biomedical fields; however, the serve burst release of drug from this kind of drug carrier limited its further applications. In this study, inspired by water strong repellency of superhydrophobic surface, the drug-loaded electrospun fibrous mat coated with superhydrophobic layer was constructed to retard and control drug release. The results indicated that the superhydrophobic coating could be simply fabricated on the drug-loaded electrospun mat by the electrospray approach, and the thickness of the superhydrophobic coating could be finely controlled by varying the deposition time. It was further found that, as compared with drug-loaded electrospun mats, drug released sustainably from the samples coated with superhydrophobic layer, and the drug release rate could be controlled by the thickness of superhydrophobic layer. In summary, the current approach of coating a superhydrophobic layer on the drug-loaded electrospun fibrous materials offered a fundament for drug sustained release.

  16. Electrospinning polyvinylidene fluoride fibrous membranes containing anti-bacterial drugs used as wound dressing.

    Science.gov (United States)

    He, Ting; Wang, Jingnan; Huang, Peilin; Zeng, Baozhen; Li, Haihong; Cao, Qingyun; Zhang, Shiying; Luo, Zhuo; Deng, David Y B; Zhang, Hongwu; Zhou, Wuyi

    2015-06-01

    The aim of this study was to synthesis drug-loaded fibrous membrane scaffolds for potential applications as wound dressing. Polyvinylidene fluoride (PVDF) fibrous membranes were loaded with enrofloxacin (Enro) drugs by using an electrospinning process, and their mechanical strength, drug release profile and anti-bacterial properties were evaluated. Enro drug-loaded PVDF membranes exhibited good elasticity, flexibility and excellent mechanical strength. The electrospinning Enro/PVDF membranes showed a burst drug release in the initial 12h, followed by sustained release for the next 3 days, which was an essential property for antibiotic drugs applied for wound healing. The drug-loaded PVDF fibrous membranes displayed excellent anti-bacterial activity toward Escherichia coli and Staphylococcus aureus. The results suggest that electrospinning PVDF membrane scaffolds loaded with drugs can be used as wound dressing. PMID:25936562

  17. The additional value of CT images interpretation in the differential diagnosis of benign vs. malignant primary bone lesions with 18F-FDG-PET/CT

    International Nuclear Information System (INIS)

    To evaluate the value of a dedicated interpretation of the CT images in the differential diagnosis of benign vs. malignant primary bone lesions with 18fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT). In 50 consecutive patients (21 women, 29 men, mean age 36.9, age range 11-72) with suspected primary bone neoplasm conventional radiographs and 18F-FDG-PET/CT were performed. Differentiation of benign and malignant lesions was separately performed on conventional radiographs, PET alone (PET), and PET/CT with specific evaluation of the CT part. Histology served as the standard of reference in 46 cases, clinical, and imaging follow-up in four cases. According to the standard of reference, conventional 17 lesions were benign and 33 malignant. Sensitivity, specificity, and accuracy in assessment of malignancy was 85%, 65% and 78% for conventional radiographs, 85%, 35% and 68% for PET alone and 91%, 77% and 86% for combined PET/CT. Median SUVmax was 3.5 for benign lesions (range 1.6-8.0) and 5.7 (range 0.8-41.7) for malignant lesions. In eight patients with bone lesions with high FDG-uptake (SUVmax ? 2.5) dedicated CT interpretation led to the correct diagnosis of a benign lesion (three fibrous dysplasias, two osteomyelitis, one aneurysmatic bone cyst, one fibrous cortical defect, 1 phosphaturic mesenchymal tumor). In four patients with lesions with low FDG-uptake (SUVmax < 2.5) dedicated CT interpretation led to the correct diagnosis of a malignant lesion (three chondrosarcomas and one leiomyosarcoma). Combined PET/CT was significantly more accurate in the differentiation of benign and malignant lesions than PET alone (p =.039). There was no significant difference between PET/CT and conventional radiographs (p =.625). Dedicated interpretation of the CT part significantly improved the performance of FDG-PET/CT in differentiation of benign and malignant primary bone lesions compared to PET alone. PET/CT more commonly differentiated benign from malignant primary bone lesions compared with conventional radiographs, but this difference was not significant. (orig.)

  18. The additional value of CT images interpretation in the differential diagnosis of benign vs. malignant primary bone lesions with 18F-FDG-PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Strobel, K.; Stumpe, K.D.M.; Hany, T.F.; Mende, K.; Veit-Haibach, P.; Schulthess, G.K. von [University Hospital Zurich, Division of Nuclear Medicine, Department of Medical Radiology, Zurich (Switzerland); Exner, U.E. [University Hospital Balgrist, Department of Orthopedic Surgery, Zurich (Switzerland); Bode, B. [University Hospital Zurich, Institute of Surgical Pathology, Zurich (Switzerland); Hodler, Juerg [University Hospital Balgrist, Department of Radiology, Zurich (Switzerland)

    2008-11-15

    To evaluate the value of a dedicated interpretation of the CT images in the differential diagnosis of benign vs. malignant primary bone lesions with 18fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT). In 50 consecutive patients (21 women, 29 men, mean age 36.9, age range 11-72) with suspected primary bone neoplasm conventional radiographs and 18F-FDG-PET/CT were performed. Differentiation of benign and malignant lesions was separately performed on conventional radiographs, PET alone (PET), and PET/CT with specific evaluation of the CT part. Histology served as the standard of reference in 46 cases, clinical, and imaging follow-up in four cases. According to the standard of reference, conventional 17 lesions were benign and 33 malignant. Sensitivity, specificity, and accuracy in assessment of malignancy was 85%, 65% and 78% for conventional radiographs, 85%, 35% and 68% for PET alone and 91%, 77% and 86% for combined PET/CT. Median SUV{sub max} was 3.5 for benign lesions (range 1.6-8.0) and 5.7 (range 0.8-41.7) for malignant lesions. In eight patients with bone lesions with high FDG-uptake (SUV{sub max} {>=} 2.5) dedicated CT interpretation led to the correct diagnosis of a benign lesion (three fibrous dysplasias, two osteomyelitis, one aneurysmatic bone cyst, one fibrous cortical defect, 1 phosphaturic mesenchymal tumor). In four patients with lesions with low FDG-uptake (SUV{sub max} < 2.5) dedicated CT interpretation led to the correct diagnosis of a malignant lesion (three chondrosarcomas and one leiomyosarcoma). Combined PET/CT was significantly more accurate in the differentiation of benign and malignant lesions than PET alone (p =.039). There was no significant difference between PET/CT and conventional radiographs (p =.625). Dedicated interpretation of the CT part significantly improved the performance of FDG-PET/CT in differentiation of benign and malignant primary bone lesions compared to PET alone. PET/CT more commonly differentiated benign from malignant primary bone lesions compared with conventional radiographs, but this difference was not significant. (orig.)

  19. Electrospun PVdF-based fibrous polymer electrolytes for lithium ion polymer batteries

    International Nuclear Information System (INIS)

    This paper discusses the preparation of microporous fibrous membranes from PVdF solutions with different polymer contents, using the electrospinning technique. Electrospun PVdF-based fibrous membranes with average fiber diameters (AFD's) of 0.45-1.38 ?m have an apparent porosity and a mean pore size (MPS) of 80-89% and 1.1-4.3 ?m, respectively. They exhibited a high uptake of the electrolyte solution (320-350%) and a high ionic conductivity of above 1 x 10-3 s/cm at room temperature. Their ionic conductivity increased with the decrease in the AFD of the fibrous membrane due to its high electrolyte uptake. The interaction between the electrolyte molecules and the PVdF with a high crystalline content may have had a minor effect on the lithium ion transfer in the fibrous polymer electrolyte, unlike in a nanoporous gel polymer electrolyte. The fibrous polymer electrolyte that contained a 1 M LiPF6-EC/DMC/DEC (1/1/1 by weight) solution showed a high electrochemical stability of above 5.0 V, which increased with the decrease in the AFD The interfacial resistance (Ri) between the polymer electrolyte and the lithium electrode slightly increased with the storage time, compared with the higher increase in the interfacial resistance of other gel polymer electrolytes. The prototype cell (MCMB/PVdF-based fibrous electrolyte/LiCoO2) showed a very stable charge-discharge behavior with a slight capacity loss under constant current and voltage conditions at the C/2-rate of 20 and 60 deg. C

  20. Water-stable three-dimensional ultrafine fibrous scaffolds from keratin for cartilage tissue engineering.

    Science.gov (United States)

    Xu, Helan; Cai, Shaobo; Xu, Lan; Yang, Yiqi

    2014-07-22

    Intrinsically water-stable scaffolds composed of ultrafine keratin fibers oriented randomly and evenly in three dimensions were electrospun for cartilage tissue engineering. Keratin has been recognized as a biomaterial that could substantially support the growth and development of multiple cell lines. Besides, three-dimensional (3D) ultrafine fibrous structures were preferred in tissue engineering due to their structural similarity to native extracellular matrices in soft tissues. Recently, we have developed a nontraditional approach to developing 3D fibrous scaffolds from alcohol-soluble corn protein, zein, and verified their structural advantages in tissue engineering. However, keratin with highly cross-linked molecular structures could not be readily dissolved in common solvents for fiber spinning, which required the remarkable drawability of solution. So far, 3D fibrous scaffolds from pure keratin for biomedical applications have not been reported. In this research, the highly cross-linked keratin from chicken feathers was de-cross-linked and disentangled into linear and aligned molecules with preserved molecular weights, forming highly stretchable spinning dope. The solution was readily electrospun into scaffolds with ultrafine keratin fibers oriented randomly in three dimensions. Due to the highly cross-linked molecular structures, keratin scaffolds showed intrinsic water stability. Adipose-derived mesenchymal stem cells could penetrate much deeper, proliferate, and chondrogenically differentiate remarkably better on the 3D keratin scaffolds than on 2D PLA fibrous scaffolds, 3D soy protein fibrous scaffolds, or 3D commercial nonfibrous scaffolds. In summary, the electrospun 3D ultrafine fibrous scaffolds from keratin could be promising candidates for cartilage tissue engineering. PMID:25010870

  1. Anti-inflammatory, anti-bacterial, and cytotoxic activity of fibrous clays.

    Science.gov (United States)

    Cervini-Silva, Javiera; Nieto-Camacho, Antonio-; Ramírez-Apan, María Teresa; Gómez-Vidales, Virginia; Palacios, Eduardo; Montoya, Ascención; Ronquillo de Jesús, Elba

    2015-05-01

    Produced worldwide at 1.2m tons per year, fibrous clays are used in the production of pet litter, animal feed stuff to roof parcels, construction and rheological additives, and other applications needing to replace long-fiber length asbestos. To the authors' knowledge, however, information on the beneficial effects of fibrous clays on health remains scarce. This paper reports on the anti-inflammatory, anti-bacterial, and cytotoxic activity by sepiolite (Vallecas, Spain) and palygorskite (Torrejon El Rubio, Spain). The anti-inflammatory activity was determined using the 12-O-tetradecanoylphorbol-13-acetate (TPA) and myeloperoxidase (MPO) methods. Histological cuts were obtained for quantifying leukocytes found in the epidermis. Palygorkite and sepiolite caused edema inhibition and migration of neutrophils ca. 68.64 and 45.54%, and 80 and 65%, respectively. Fibrous clays yielded high rates of infiltration, explained by cleavage of polysomes and exposure of silanol groups. Also, fibrous clays showed high inhibition of myeloperoxidase contents shortly after exposure, but decreased sharply afterwards. In contrast, tubular clays caused an increasing inhibition of myeloperoxidase with time. Thus, clay structure restricted the kinetics and mechanism of myeloperoxidase inhibition. Fibrous clays were screened in vitro against human cancer cell lines. Cytotoxicity was determined using the protein-binding dye sulforhodamine B (SRB). Exposing cancer human cells to sepiolite or palygorskite showed growth inhibition varying with cell line. This study shows that fibrous clays served as an effective anti-inflammatory, limited by chemical transfer and cellular-level signals responding exclusively to an early exposure to clay, and cell viability decreasing significantly only after exposure to high concentrations of sepiolite. PMID:25819359

  2. Expression of multidrug-resistance-associated protein gene in human soft-tissue sarcomas.

    Science.gov (United States)

    Oda, Y; Schneider-Stock, R; Ry?, J; Gruchala, A; Niezabitowski, A; Roessner, A

    1996-01-01

    We examined the mRNA expression of the multidrug- resistance-associated protein gene (MRP) in soft-tissue sarcomas and compared it with the expression of the multidrug resistance gene (MDR1), using the reverse transcriptase/polymerase chain reaction. We investigate 39 samples from 33 cases of soft-tissue sarcomas (11 liposarcomas, 9 malignant fibrous histiocytomas, 6 leiomyosarcomas, 4 malignant schwannomas, 3 fibrosarcomas, 3 synovial sarcomas, and 3 epithelioid sarcomas) and 7 benign soft-tissue tumors. All samples were obtained prior to chemotherapy. An expression of MRP mRNA was noted in 56% of soft-tissue sarcoma specimens. The co-expression of MRP and MDR1 was recognized in 15 samples (38%) (5/11 liposarcomas, 5/9 malignant fibrous histiocytomas, 3/6 leiomyosarcomas, 2/3 fibrosarcomas) and significantly correlated with histological grade (P=0.0165). A positive and significant correlation was found between MRP and MDR1 expression in soft-tissue sarcomas(P=0.0013). In benign soft-tissue tumors, 1 chemodectoma and 1 neurothekeoma showed low MRP expression; however, no case showed co-expression of MRP and MDR1. PMID:8601564

  3. Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

    Science.gov (United States)

    2015-12-31

    Adult Fibrosarcoma; Alveolar Soft Part Sarcoma; Angiomatoid Fibrous Histiocytoma; Atypical Fibroxanthoma; Clear Cell Sarcoma of Soft Tissue; Epithelioid Malignant Peripheral Nerve Sheath Tumor; Epithelioid Sarcoma; Extraskeletal Myxoid Chondrosarcoma; Extraskeletal Osteosarcoma; Fibrohistiocytic Neoplasm; Glomus Tumor of the Skin; Inflammatory Myofibroblastic Tumor; Intimal Sarcoma; Leiomyosarcoma; Liposarcoma; Low Grade Fibromyxoid Sarcoma; Low Grade Myofibroblastic Sarcoma; Malignant Cutaneous Granular Cell Tumor; Malignant Peripheral Nerve Sheath Tumor; Malignant Triton Tumor; Mesenchymal Chondrosarcoma; Myxofibrosarcoma; Myxoid Chondrosarcoma; Myxoinflammatory Fibroblastic Sarcoma; Nerve Sheath Neoplasm; PEComa; Pericytic Neoplasm; Plexiform Fibrohistiocytic Tumor; Sclerosing Epithelioid Fibrosarcoma; Stage IB Soft Tissue Sarcoma; Stage IIB Soft Tissue Sarcoma; Stage III Soft Tissue Sarcoma; Stage IV Soft Tissue Sarcoma; Synovial Sarcoma; Undifferentiated (Embryonal) Sarcoma; Undifferentiated High Grade Pleomorphic Sarcoma of Bone

  4. Surgically cured hypoglycemia secondary to pleural solitary fibrous tumour: case report and update review on the Doege-Potter syndrome

    Directory of Open Access Journals (Sweden)

    Kalebi Ahmed Y

    2009-08-01

    Full Text Available Abstract The association of paraneoplastic hypoglycemia [Doege-Potter syndrome] and finger clubbing [Pierre-Marie-Bamberg syndrome] with pleural solitary fibrous tumour is rare. We present a previously unpublished but typical example of this rare occurrence together with a detailed updated literature review of previously published cases of pleural SFT discussing the histopathology of SFT; pathophysiology of the hypoglycemia and finger clubbing; treatment and outcome of pleural SFT. The patient, a 57-year-old African male was admitted at our hospital with recurrent episodes of hypoglycemia. He was found to have digital clubbing and decreased breath sounds in the right lower chest but no other significant clinical findings. His insulin level measured during an episode of hypoglycemia was undetectable. Chest radiograph and CT-scan revealed a lobulated mass in the right chest which was diagnosed to be SFT on histology. Surgical excision of the mass resulted in cure of the hypoglycemic episodes and rapid regression of the clubbing. Less than 65 cases of pleural SFT manifesting with hypoglycemia with or without finger-clubbing have been published in the English literature. The mean diameter of these tumours manifesting with hypoglycemia is 20 cm, 54% being benign while 42% were malignant. They predominantly present in the 6th-8th decade, average age of 64 years and a slight male preponderance at 58%. Complete surgical resection remains the most important predictor of clinical outcome in terms of recurrence and metastases, while providing instant cure for the hypoglycemia and rapid resolution of the finger clubbing.

  5. Analytical estimation for static deformation of wire ropes with fibrous core

    Science.gov (United States)

    Kumar, K.; Cochran, J. E., Jr.

    1990-01-01

    This paper develops closed-form solutions for the extension of twisted wire ropes with fibrous cores which are subjected to axial forces as well as axial moments. The analytical results are compared with the corresponding numerical results obtained by Costello and Phillips. A close agreement between the two establishes validity of the analytical solutions. Finally, an expression for the effective rigidity modulus of wire ropes with fibrous core is obtained in terms of the helix angle and the number of helical wires in the rope for each of the two end conditions.

  6. Structured multiphase reactors based on fibrous catalysts: nitrite hydrogenation as a case study

    OpenAIRE

    Holler, V; Yuranov, I.; Kiwi-Minsker, L; Renken, A.

    2001-01-01

    A reactor concept designed as a bubble column staged with fibrous catalytic layers is tested on pilot-scale for the redn. of nitrite to N by H. CO2 is used to neutralize the hydroxide ions produced during hydrogenation of nitrite. The effective reaction rate was found to depend on the superficial gas velocity ug0. The fibrous catalysts demonstrated a high selectivity towards nitrogen. The influence of the mass transport on the effective kinetics is discussed and the volumetric liq.-solid mass...

  7. Myxoid Solitary Fibrous Tumor of the Retroperitoneum: MRI Findings with the Pathologic Correlation

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Sang Soo [Chonnam National University Hospital, Gwangju (Korea, Republic of); Jeong, Yong Yeon; Kang, Heoung Keun [Chonnam National University Hwasun Hospital, Hwasun (Korea, Republic of)

    2008-06-15

    We report here on a case of solitary fibrous tumor of the retroperitoneum, and the tumor displayed a predominantly myxoid histology. A 56-year-old man presented with an incidentally detected retroperitoneal mass. On the MR images, the mass was observed as having iso-signal intensity on the T1-weighted images and high signal intensity on the fat-saturated T2-weighted images. The mass showed intense enhancement on the Gd-DTPA enhanced T1-weighted images. At surgery, a well-defined solid mass was found in the left retroperitoneum. The histological diagnosis was made as solitary fibrous tumor with a predominantly myxoid histology.

  8. Exploiting BSA to Inhibit the Fibrous Aggregation of Magnetic Nanoparticles under an Alternating Magnetic Field

    Directory of Open Access Journals (Sweden)

    Ning Gu

    2013-03-01

    Full Text Available The alternating magnetic field was discovered to be capable of inducing the fibrous aggregation of magnetic nanoparticles. However, this anisotropic aggregation may be unfavorable for practical applications. Here, we reported that the adsorption of BSA (bovine serum albumin on the surfaces of magnetic nanoparticles can effectively make the fibrous aggregation of ?-Fe2O3 nanoparticles turn into a more isotropic aggregation in the presence of the alternating magnetic field. Also, the heating curves with and without BSA adsorption under different pH conditions were measured to show the influence of the colloidal aggregation states on the collective calorific behavior of magnetic nanoparticles.

  9. Nanoscale Piezoelectric Properties of Self-Assembled Fmoc-FF Peptide Fibrous Networks.

    Science.gov (United States)

    Ryan, Kate; Beirne, Jason; Redmond, Gareth; Kilpatrick, Jason I; Guyonnet, Jill; Buchete, Nicolae-Viorel; Kholkin, Andrei L; Rodriguez, Brian J

    2015-06-17

    Fibrous peptide networks, such as the structural framework of self-assembled fluorenylmethyloxycarbonyl diphenylalanine (Fmoc-FF) nanofibrils, have mechanical properties that could successfully mimic natural tissues, making them promising materials for tissue engineering scaffolds. These nanomaterials have been determined to exhibit shear piezoelectricity using piezoresponse force microscopy, as previously reported for FF nanotubes. Structural analyses of Fmoc-FF nanofibrils suggest that the observed piezoelectric response may result from the noncentrosymmetric nature of an underlying ?-sheet topology. The observed piezoelectricity of Fmoc-FF fibrous networks is advantageous for a range of biomedical applications where electrical or mechanical stimuli are required. PMID:25994251

  10. Primary Solitary Fibrous Tumor of the Thyroid - Report of a Case and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Zhigang Song, Chunkai Yu, Xin Song, Lixin Wei, Aijun Liu

    2011-01-01

    Full Text Available Solitary fibrous tumor (SFT is a rare spindle-cell neoplasm, especially in the thyroid. We report a case of primary solitary fibrous tumor of the thyroid gland in a 37 year-old Chinese man. The tumor was characterized by bland-looking spindle cells admixed with thin and thick collagen fibers. On immunohistochemistry study indicated that tumor cells were diffusely positive for CD34, Bcl-2 and CD99, and negative for Desmin, NSE, SMA, S-100, and CD68. The patient remains well 16 months after excision. The morphologic and immunohistochemical features of the thyroid SFTs are similar to their reported counterparts in other anatomic sites.

  11. Improving soil quality with lignitic fibrous xylite; Verbesserung der Bodenqualitaet mit Braunkohlenfaserxylit

    Energy Technology Data Exchange (ETDEWEB)

    Strassburger, U.; Naundorf, W.; Schroeder, H.W. [TU Bergakademie Freiberg, Erich-Rammler-Bau, Freiberg (Germany); Biegel, A. [Vattenfall Europe Mining AG, Senftenberg (Germany)

    2004-06-01

    On behalf of Vattenfall Europe Mining AG, the professorship of agglomeration technology and air purification at the Freiberg University of Mining and Technology carried out extensive studies during the last few years in order to examine the suitability of processed, coal-free fibrous xylite as a soil modifier. This article presents partial results. These results were primarily obtained when fibrous xylite was added to: - excavation residue from a lignite open pit mine - sandy soil without humus components (building sand) - limestone soil which accrued during construction work. At the same time, comparison tests were carried out with garden mould and compost soil. (orig.)

  12. An Investigation of the Radiative Heat Transfer through Nonwoven Fibrous Materials

    OpenAIRE

    Imad Qashou; Hooman Vahedi Tafreshi; Behnam Pourdeyhimi

    2009-01-01

    In this study, the surface-to-surface radiation model of the Fluent CFD code is used to investigate the response of a fibrous material to the radiative heat transfer. The unsteady state heat transfer equation is solved for the temperature and heat flux in and around the fibers that constitute a nonwoven fibrous material. For a fixed fiber diameter, it was shown that the higher the fabric’s Solid Volume Fraction (SVF), the slower is the material’s average temperature rise. Our simulation resul...

  13. Nitridated fibrous silica (KCC-1) as a sustainable solid base nanocatalyst

    KAUST Repository

    Bouhrara, Mohamed

    2013-09-03

    We observed that support morphology has dramatic effects on the performance of nitridated silica as a base. By simply replacing conventional silica supports (such as SBA-15 and MCM-41) with fibrous nanosilica (KCC-1), we observed multifold enhancement in the catalytic activity of the nitridated solid base for Knoevenagel condensations and transesterification reactions. This enhancement of the activity can be explained by amine accessibility, which is excellent in KCC-1 due to its open and flexible fibrous structure, that facilitates penetration and interaction with basic amine sites. © 2013 American Chemical Society.

  14. The psychosocial aspects of malignancy.

    Science.gov (United States)

    Kriesel, H T

    1987-06-01

    This article has described many of the psychosocial issues associated with malignancy. Issues related to delivering the diagnosis of cancer, such as telling the truth, including the family, and initiating a "shared meaning" process, were considered. Patient reactions related to cancer such as grief, depression, and needs for control were described. Family reactions to the cancer patient, including anticipatory grief and weariness, were noted. The need for psychosocial support for the family of the cancer patient was discussed. Finally, the need for caregivers to pay attention to their own emotional needs was described. PMID:3299423

  15. Malignant melanoma of the skin

    OpenAIRE

    Armstrong, B. K.; Holman, C. D. J.

    1987-01-01

    Ultra-violet radiation (UVR) in sunlight is thought to be the main cause of malignant melanoma in lightly-pigmented populations. Individuals with fair skin, fair hair, blue eyes and/or a tendency to burn rather than tan when exposed to the sun are at particularly high risk of melanoma and should be given special attention in primary prevention programmes. Intermittent exposure to the sun, as in recreational exposure, may be a more potent cause of melanoma than more continuous exposure. Primar...

  16. Meningeal metastasing of malignant melanomas

    International Nuclear Information System (INIS)

    Two woman patients with malignant melanoma of the skin known from their case history and with acutely emerging neurological symptoms were examined both by CT and by MR tomography (both plain and with intravenous contrast medium). The radiologically derived suspicion of meningioma could not be confirmed by intraoperatively performed histological examination. In both cases the patients had meningeal melanoma metastases with low melanin content and without noticeable bleeding into the metastases. MR diagnosis is rendered difficult by the absence of paramagnetic substances typical of melanoma metastases. Hence, if the case history is known, it should be considered whether there is meningeal metastasising with atypical histology. (orig.)

  17. Antibacterial and anti-adhesion effects of the silver nanoparticles-loaded poly(L-lactide) fibrous membrane

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Shen [Department of Orthopaedics, Shanghai Sixth People' s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233 (China); Zhao, Jingwen [Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215007 (China); School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030 (China); Ruan, Hongjiang; Wang, Wei [Department of Orthopaedics, Shanghai Sixth People' s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233 (China); Wu, Tianyi [Department of Orthopaedic Surgery, 2nd Affiliated hospital of Nanjing Medical University, Nanjing Medical University, 121 Jiang Jia Yuan, Nanjing 210011 (China); Cui, Wenguo, E-mail: wgcui80@hotmail.com [Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215007 (China); School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030 (China); Fan, Cunyi, E-mail: fancunyi888@hotmail.com [Department of Orthopaedics, Shanghai Sixth People' s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233 (China)

    2013-04-01

    The complications of tendon injury are frequently compromised by peritendinous adhesions and tendon sheath infection. Physical barriers for anti-adhesion may increase the incidence of postoperative infection. This study was designed to evaluate the potential of silver nanoparticles (AgNPs)-loaded poly(L-lactide) (PLLA) electrospun fibrous membranes to prevent adhesion formation and infection. Results of an in vitro drug release study showed that a burst release was followed by sustained release from electrospun fibrous membranes with a high initial silver content. Fewer fibroblasts adhered to and proliferated on the AgNP-loaded PLLA electrospun fibrous membranes compared with pure PLLA electrospun fibrous membrane. In the antibacterial test, the AgNP-loaded PLLA electrospun fibrous membranes can prevent the adhesion of Gram-positive Staphylococcus aureus and Staphylococcus epidermidis and Gram-negative Pseudomonas aeruginosa. Taken together, these results demonstrate that AgNP-loaded PLLA electrospun fibrous membranes have the convenient practical medical potential of reduction of infection and adhesion formation after tendon injury. - Highlights: ? Silver nanoparticles are directly electrospun into PLLA fibrous membrane. ? Long-lasting release of Ag + ions is achieved. ? Cytotoxicity of silver ions benefits the anti-proliferation of physical barriers. ? Broad anti-microbial effect of drug-loaded fibrous membrane is revealed. ? Antibacterial and anti-adhesion effects of the physical barriers are combined.

  18. Antibacterial and anti-adhesion effects of the silver nanoparticles-loaded poly(L-lactide) fibrous membrane

    International Nuclear Information System (INIS)

    The complications of tendon injury are frequently compromised by peritendinous adhesions and tendon sheath infection. Physical barriers for anti-adhesion may increase the incidence of postoperative infection. This study was designed to evaluate the potential of silver nanoparticles (AgNPs)-loaded poly(L-lactide) (PLLA) electrospun fibrous membranes to prevent adhesion formation and infection. Results of an in vitro drug release study showed that a burst release was followed by sustained release from electrospun fibrous membranes with a high initial silver content. Fewer fibroblasts adhered to and proliferated on the AgNP-loaded PLLA electrospun fibrous membranes compared with pure PLLA electrospun fibrous membrane. In the antibacterial test, the AgNP-loaded PLLA electrospun fibrous membranes can prevent the adhesion of Gram-positive Staphylococcus aureus and Staphylococcus epidermidis and Gram-negative Pseudomonas aeruginosa. Taken together, these results demonstrate that AgNP-loaded PLLA electrospun fibrous membranes have the convenient practical medical potential of reduction of infection and adhesion formation after tendon injury. - Highlights: ? Silver nanoparticles are directly electrospun into PLLA fibrous membrane. ? Long-lasting release of Ag + ions is achieved. ? Cytotoxicity of silver ions benefits the anti-proliferation of physical barriers. ? Broad anti-microbial effect of drug-loaded fibrous membrane is revealed. ? Antibacterial and anti-adhesion effects of the physical barriers are combined

  19. Case report: fibrous dysplasia of the navicular bone treated with excision of navicular and talo-cuneiform arthrodesis.

    Science.gov (United States)

    Siu, W; Ferguson, K B; Kumar, C S; Mahendra, A

    2015-03-01

    Fibrous dysplasia is an uncommon beningn disorder of bone. It usually affects the long bones, and is uncommon in the navicular. We describe a case of fibrous dysplasia of the navicular successfully treated with navicular excision and talo-cuneiform arthrodesis. PMID:25542678

  20. Mandibular malignant triton tumor: A case report

    OpenAIRE

    Jahnshah Salehinejad; Tooraj Vaezi; reza Zare; Shadi Saghafi; Amin Rahpeima; saeideh Khage Ahmadi

    2009-01-01

    Introduction:Malignant peripheral nerve sheath tumors (MPNSTs) are very rare. Malignant triton tumor is an aggressive variety of MPNSTs with rhabdomyoblastic differentiation. In this study we reported the clinical, radiographic, histopathologic and immunohistochemical features of an intramandibular malignant triton tumor. Case Report: The patient was a 31 year-old male who was referred to maxillofacial surgery ward of Mashhad dental school with a painful swelling in the anterior part of mandi...

  1. Malignant Triton Tumor: A Rare Case

    OpenAIRE

    Shetty, Prasad K; Baliga, Sameer V.; Balaiah, Kopparthi

    2012-01-01

    Malignant triton tumor (MTT) is a malignant peripheral nerve sheath tumor (MPNST) with rhabdomyoblastic differentiation. This rare tumor, with fewer than 100 cases reported in the literature, generally affects adult patients with neurofibromatosis 1 (NF-1). We report such a case in a 34-year-old man with NF-1 who presented with a mass over the medial side of the arm. Histopathologically finding of rhabdomyoblasts among malignant Schwann cells in a tumor arising from a peripheral nerve support...

  2. Delayed Onset Malignant Hyperthermia after Sevoflurane

    OpenAIRE

    K. Sanem Cakar Turhan; Volkan Bayta?; Ye?im Batislam; Oya Özatamer

    2013-01-01

    Malignant hyperthermia is a hypermetabolic response to inhalation agents (such as halothane, sevoflurane, and desflurane), succinylcholine, vigorous exercise, and heat. Reactions develop more frequently in males than females (2?:?1). The classical signs of malignant hyperthermia are hyperthermia, tachycardia, tachypnea, increased carbon dioxide production, increased oxygen consumption, acidosis, muscle rigidity and rhabdomyolysis. In this case report, we present a case of delayed onset malign...

  3. Cerebellar degeneration following neuroleptic malignant syndrome.

    OpenAIRE

    Lal, V.; Sardana, V.; Thussu, A; Sawhney, I M; S. Prabhakar

    1997-01-01

    A 55-year-old woman with a history of bipolar affective disorder developed hyperpyrexia, rigidity and depressed consciousness (neuroleptic malignant syndrome) after commencing neuroleptic therapy. On regaining consciousness, she was mute and had signs suggesting pancerebellar involvement. Hyperpyrexia, which is a cardinal feature of neuroleptic malignant syndrome, may have caused cerebellar damage. Neuroleptic malignant syndrome needs both early recognition and prompt treatment to obviate dev...

  4. Malignant acanthosis nigricans with occult primary

    Directory of Open Access Journals (Sweden)

    Thomas Moly

    2002-11-01

    Full Text Available A case of generalized malignant acanthosis nigricans of 2 years duration is reported. In spite of the long duration of this cutaneous marker of internal malignancy, the patient was completely asymptamatic and extensive investigations revealed the presence of widespread metastasis of mucin secreting signet cell adenocarcinoma from an unknown primary site. In addition the patient also had acquired hypertrichosis lanuginose and florid cutaneous papillomatosis which are also markers of internal malignancy.

  5. Mistletoe in the treatment of malignant melanoma

    Directory of Open Access Journals (Sweden)

    Esin Sakall? Çetin

    2014-03-01

    Full Text Available Malignant melanoma is a malignant neoplasia drives from melanocytes. Malignant melanoma, the most causing death, is seen in the third place at skin cancer. Malignant melanoma shows intrinsic resistance to chemotherapeutic agents and variability in the course of the disease which are distinct features separating from other solid tumors. These features prevent the development and standardization of non-surgical treatment models of malignant melanoma. Although there is a large number of chemotherapeutic agents used in the treatment of metastatic malignant melanoma, it hasn’t been demonstrated the survival advantage of adjuvant treatment with chemotherapeutic agents. Because of the different clinical course of malignant melanoma, the disease is thought to be closely associated with immune system. Therefore, immunomodulatory therapy models were developed. Mistletoe stimulates the immune system by increasing the number and activity of dendritic cells, thus it has been shown to effect on tumor growth and metastasis of malignant melanoma patient. Outlined in this review are the recent developments in the understanding the role of mistletoe as a complementary therapy for malignant melanoma. J Clin Exp Invest 2014; 5 (1: 145-152

  6. Malignant small round cell tumors

    Directory of Open Access Journals (Sweden)

    Rajwanshi Arvind

    2009-01-01

    Full Text Available Malignant small round cell tumors are characterised by small, round, relatively undifferentiated cells. They generally include Ewing?s sarcoma, peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin?s lymphoma, retinoblastoma, neuroblastoma, hepatoblastoma, and nephroblastoma or Wilms? tumor. Other differential diagnoses of small round cell tumors include small cell osteogenic sarcoma, undifferentiated hepatoblastoma, granulocytic sarcoma, and intraabdominal desmoplastic small round cell tumor. Differential diagnosis of small round cell tumors is particularly difficult due to their undifferentiated or primitive character. Tumors that show good differentiation are generally easy to diagnose, but when a tumor is poorly differentiated, identification of the diagnostic, morphological features is difficult and therefore, no definitive diagnosis may be possible. As seen in several study reports, fine needle aspiration cytology (FNAC has become an important modality of diagnosis for these tumors. The technique yields adequate numbers of dissociated, viable cells, making it ideally suitable for ancillary techniques. Typically, a multimodal approach is employed and the principal ancillary techniques that have been found to be useful in classification are immunohistochemistry and immunophenotyping by flow cytometry, reverse transcriptase polymerase chain reaction (RT-PCR, fluorescence in situ hybridization (FISH, and electron microscopy. However, the recent characterization of chromosomal breakpoints and the corresponding genes involved in malignant small round cell tumors means that it is possible to use molecular genetic approaches for detection.

  7. A Case of Malignant Peripheral Nerve Sheath Tumor with Rhabdomyoblastic Differentiation: Malignant Triton Tumor

    OpenAIRE

    Mae, Kenichiro; Kato, Yukihiko; Usui, Kae; Abe, Namiko; Tsuboi, Ryoji

    2013-01-01

    Malignant peripheral nerve sheath tumors (MPNST) constitute a rare variety of soft tissue sarcomas thought to originate from Schwann cells or pluripotent cells of the neural crest. Malignant triton tumor (MTT), a very rare, highly aggressive soft tissue tumor, is a subgroup of MPNST and is comprised of malignant Schwann cells coexisting with malignant rhabdomyoblasts. We herein report the case of a 24-year-old man who presented a subcutaneous mass in his right thigh. The mass was removed surg...

  8. Crystal networks in silk fibrous materials: from hierarchical structure to ultra performance.

    Science.gov (United States)

    Nguyen, Anh Tuan; Huang, Qiao-Ling; Yang, Zhen; Lin, Naibo; Xu, Gangqin; Liu, Xiang Yang

    2015-03-01

    This review provides a comprehensive survey of the structural characteristics of crystal networks of silk soft fibrous materials in correlation with the macroscopic properties/performance and the network formation mechanisms. The correlation between the hierarchical mesoscopic structures and the mechanical properties of silk soft fibrous materials including silk fibroin hydrogels and naturally spun silk fibers are addressed based on the hierarchical crystal network models. Namely, two types of hierarchical networks are identified: the weak nanofibril-nanofibril interaction case (i.e., silk fibroin hydrogels), and the strong nanofibril-nanofibril interaction case (i.e., silk fibers). The macroscopic properties, i.e., the rheological/mechanical properties, can be controlled in terms of tuning different levels of hierarchical network structures by ultrasonication-induced gelation, introducing the initial nucleation centers, etc. Such controls take effect by different mesoscale assembly pathways, which are found to occur via different routes of the nucleation and growth processes. Furthermore, the hierarchical network model of soft fibrous materials can be applied to explain the superior mechanical properties and the unique strain-hardening behaviors of spider silk fibers within the framework of hierarchical breaking mechanism. Obviously, a knowledge of crystal networks will allow the prediction of the performance and engineering strategy of silk fibrous materials in generals. PMID:25510895

  9. Acoustic and Visul Study of Bubble Formation Processes in Bubble Columns Staged with Fibrous Catalytic Layers.

    Czech Academy of Sciences Publication Activity Database

    Höller, V.; R?ži?ka, Marek; Drahoš, Ji?í; Kiwi-Minsker, L.; Renken, A.

    79-80, - (2003), s. 151-157. ISSN 0920-5861 Institutional research plan: CEZ:AV0Z4072921 Keywords : bubble formation * fibrous catalytic layers * staged bubble column Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 2.627, year: 2003

  10. Electro spun Polyamide 4.6 Nano fibrous Nonwoven: Parameter Study and Characterization

    International Nuclear Information System (INIS)

    The aliphatic polyamide 4.6 (PA 4.6) has unique properties compared to the commonly used polyamides 6 (PA 6) and 6.6 (PA 6.6). The purpose of this paper is to produce uniform and reproducible nano fibrous PA 4.6 structures. Therefore, a mixture of the solvent formic acid and the non solvent acetic acid is used to dissolve and electro spin the PA 4.6. First the steady-state behaviour of the process and the boundary limits of the solution parameters needed for steady-state electro spinning are investigated. Subsequently, the effect of several solution and process parameters on the fibre morphology is examined, using microscopic techniques and thermal analysis. The polyamide concentration is found to be the dominant parameter affecting the fibre diameter and morphology. Furthermore, tensile tests are performed on up scaled nano fibrous structures and electro spun under optimised steady-state conditions. It is shown that the PA 4.6 nano fibrous structures, compared to nano fibrous nonwoven s of PA 6 and PA 6.6, have a higher stress and strain at break.

  11. THE INFLUENCE OF BASALT FIBERS ON STRENGTH OF FINE-GRAINED FIBROUS CONCRETE / ??????? ??????????? ??????? ?? ????????? ?????????????? ????????????

    Directory of Open Access Journals (Sweden)

    Perfilov Vladimir Aleksandrovich / ???????? ???????? ?????????????

    2015-02-01

    Full Text Available The authors present the results of experimental studies on the determination of the number of basalt fibers with the length of 12 mm and the diameter of 10 ?m to obtain fine-grained fibrous concrete with maximum strength in bending and compression / ???????????? ?????????? ????????????????? ???????????? ?? ??????????? ?????????? ??????????? ???????? ??????? ?????? 12 ?? ? ????????? 10 ??? ??? ????????? ?????????????? ???????????? ? ???????????? ?????????? ?? ????? ? ??????

  12. Dissolving behavior and calcium release from fibrous wollastonite in acetic acid solution

    Energy Technology Data Exchange (ETDEWEB)

    Ptacek, Petr, E-mail: ptacek@fch.vutbr.cz [Institute of Materials Science, Faculty of Chemistry, Brno University of Technology, Purkynova 464/118, Brno CZ-621 00 (Czech Republic); Noskova, Magdalena; Brandstetr, Jiri; Soukal, Frantisek; Opravil, Tomas [Institute of Materials Science, Faculty of Chemistry, Brno University of Technology, Purkynova 464/118, Brno CZ-621 00 (Czech Republic)

    2010-01-20

    The degradability of fibrous wollastonite (CaSiO{sub 3}) in an aqueous solution of acetic acid and leaching of Ca{sup 2+} ions were investigated in the temperature range from 22 to 50 {sup o}C. The Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-OES) was used for the assessment of calcium and other selected cations in the leaching medium. The amount of calcium in the solvent can be significantly enhanced through leaching at higher temperature. Fibrous silica particles are the main by-product of the leaching process. The properties of by-product were examined by thermal analysis (simultaneous TG-DTA-EGA), infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The formation of silica layer on the surface of fibrous wollastonite particles is an important factor in the leaching process. Particles were covered by the silica layer and wollastonite core size was continually decreasing during leaching. The shape of resulting silica particles shows no significant changes during this process. Specific surface of the formed fibrous silica particles strongly depends on the leaching temperature.

  13. Dissolving behavior and calcium release from fibrous wollastonite in acetic acid solution

    International Nuclear Information System (INIS)

    The degradability of fibrous wollastonite (CaSiO3) in an aqueous solution of acetic acid and leaching of Ca2+ ions were investigated in the temperature range from 22 to 50 oC. The Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-OES) was used for the assessment of calcium and other selected cations in the leaching medium. The amount of calcium in the solvent can be significantly enhanced through leaching at higher temperature. Fibrous silica particles are the main by-product of the leaching process. The properties of by-product were examined by thermal analysis (simultaneous TG-DTA-EGA), infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The formation of silica layer on the surface of fibrous wollastonite particles is an important factor in the leaching process. Particles were covered by the silica layer and wollastonite core size was continually decreasing during leaching. The shape of resulting silica particles shows no significant changes during this process. Specific surface of the formed fibrous silica particles strongly depends on the leaching temperature.

  14. Experimental and theoretical studies on high-temperature thermal properties of fibrous insulation

    International Nuclear Information System (INIS)

    In the present paper, an experimental apparatus has been developed to measure heat transfer through high-alumina fibrous insulation for thermal protection system. Effective thermal conductivities of the fibrous insulation were measured over a wide range of temperature (300-973 K) and pressure (10-2-105 Pa) using the developed apparatus. The specific heat and the transmittance spectra in the wavelength range of 2.5-25 ?m were also measured. The spectral extinction coefficients and Rosseland mean extinction coefficients were obtained from transmittance data at various temperatures to investigate the radiative heat transfer in fibrous insulation. A one-dimensional finite volume numerical model combined radiation and conduction heat transfer was developed to predict the behavior of the effective thermal conductivity of the fibrous insulation at various temperatures and pressures. The two-flux approximation was used to model the radiation heat transfer through the insulation. The experimentally measured specific heat and Rosseland mean extinction coefficients were used in the numerical heat transfer model to calculate the effective thermal conductivity. The average deviation between the numerical results for different values of albedo of scattering and the experimental results was investigated. The numerical results for ?=1 and experimental data were compared. It was found that the calculated values corresponded with the experimental values within an average of 13.5 percent. Numerical results were consistent with experimental results through the environmental conditions under examination

  15. Flight Performance of an Advanced Thermal Protection Material: Toughened Uni-Piece Fibrous Insulation

    Science.gov (United States)

    Leiser, Daniel B.; Gordon, Michael P.; Rasky, Daniel J. (Technical Monitor)

    1995-01-01

    The flight performance of a new class of low density, high temperature thermal protection materials (TPM) is described and compared to "standard" Space Shuttle TPM. This new functionally gradient material designated as Toughened Uni-Piece Fibrous Insulation (TUFI), was bonded on a removable panel attached to the base heat shield of Orbiter 105, Endeavour.

  16. Inhibition of fibrous adhesion formation in the temporomandibular joint of tenascin-C knockout mice

    Directory of Open Access Journals (Sweden)

    Y. Shinohara

    2014-10-01

    Full Text Available Tenascin-C (TNC is a large hexameric extracellular matrix glycoprotein that is expressed in developing organs and tumors. It has been reported that TNC is expressed in inflamed synovial membranes and deformed discs of temporomandibular joint (TMJ disorder. However, the role of TNC in TMJ is not fully known. In this study, the role of TNC in fibrous adhesion formation of TMJ was examined using TNC knockout (TNCKO mice. Hypermobility was produced by excessive mouth opening method on the TMJ of both wild-type (WT and TNCKO mice. TMJ wound healing was compared histologically, and the expression of TNC, fibronectin (FN and ?-smooth muscle actin (?-SMA in the wounded TMJ was examined by immunohistochemical and immunoblot analyses. Based on histologic analysis, fibrous adhesions were observed in the TMJ of both TNCKO and wild-type (WT mice after excessive mouth opening. However, fibrous adhesion formation in TNCKO mice occurred later than in WT mice. TNC was expressed in the wounded TMJ disc and mandibular fossa. Although FN and ?-SMA expression in the TMJ of TNCKO and WT mice was up-regulated after excessive mouth opening, FN and ?-SMA protein levels were higher in WT mice at the same time points. In the wounded TMJ, TNC appears to enhance the expression of FN and ?-SMA, and a lack of TNC may reduce fibrous adhesion formation in the TMJ. TNC plays an important role in TMJ wound healing, especially for wounds generated by mechanical stress.

  17. 3D multi-layered fibrous cellulose structure using an electrohydrodynamic process for tissue engineering.

    Science.gov (United States)

    Kim, Minseong; Kim, GeunHyung

    2015-11-01

    Micro/nanofibrous structures have been applied widely in various tissue-engineering applications because the topological structures are similar to the extracellular matrix (ECM), which encourages a high degree of cell adhesion and growth. However, it has been difficult to produce a three-dimensional (3D) fibrous structure using controllable macro-pores. Recently, cellulose has been considered a high-potential natural-origin biomaterial, but its use in 3D biomedical structures has been limited due to its narrow processing window. Here, we suggest a new 3D cellulose scaffold consisting of multi-layered struts made of submicron-sized entangled fibers that were fabricated using an electrohydrodynamic direct jet (EHDJ) process that is spin-printing. By optimizing processing conditions (electric field strength, cellulose feeding rate, and distance between nozzle and target), we can achieve a multi-layered cellulose structure consisting of the cylindrically entangled cellulose fibers. To compare the properties of the fabricated 3D cellulose structure, we used a PCL fibrous scaffold, which has a similar fibrous morphology and pore geometry, as a control. The physical and in vitro biocompatibilities of both fibrous scaffolds were assessed using human dermal fibroblasts, and the cellulose structure showed higher cell adhesion and metabolic activities compared with the control. These results suggest the EHDJ process to be an effective fabricating tool for tissue engineering and the cellulose scaffold has high potential as a tissue regenerative material. PMID:26164251

  18. Non-contact ultrasonic technique for rapid and advanced analysis of fibrous materials

    Science.gov (United States)

    Periyaswamy, T.; Lerch, T. P.; Balasubramanian, K.

    2012-05-01

    Fibrous ensembles are, typically, multi-scale flexible assemblies with unique physical and rheological properties, unlike continuum materials. Macroscopic behaviors of these materials are greatly the result of non-linear interactions at the micro levels. These micro-scale interactions can be assessed by capturing the material behavior under low mechanical stress conditions. While ultrasonic based non-destructive testing was suitably implemented for continuum materials, their application to fibrous structures was limited primarily due to the inherent structural arrangements of these unique assemblies. Discontinuities, non-uniform orientations and multi-phase components make these ensembles difficult to study using the existing scan-based methods. This work presents a novel rapid and advanced analysis tool for complex fibrous systems using a noncontact air-coupled ultrasonic system. Five characteristic features of ultrasound signals transmitted through fibrous structures were studied, i.e., dampness in signal flight, signal velocity, power spectral density, signal power and rate of amplitude attenuation. Analysis of these features under two different acoustic frequencies, 500 kHz and 1 MHz, allowed us to study the componentized behavior of these materials for three of the key mechanical properties including bending rigidity, shear rigidity and low stress tensile stress. A material response index (MRI) was also derived using the signal features.

  19. Acoustic and Visual Study of Bubble Formation Processes in Bubble Columns Staged with Fibrous Catalytic Layers.

    Czech Academy of Sciences Publication Activity Database

    Höller, V.; R?ži?ka, Marek; Drahoš, Ji?í; Kivi-Minsker, L.; Renken, A.

    2002, s. 1-2. [International Symposium Catalysis in Multiphase Reactors /4./. Lausanne (CH), 22.09.2002-25.09.2002] Institutional research plan: CEZ:AV0Z4072921 Keywords : bubble columns * fibrous catalytic layers * visual study Subject RIV: CI - Industrial Chemistry, Chemical Engineering

  20. Unusual malignant tumors of the breast: MRI features and pathologic correlation

    International Nuclear Information System (INIS)

    Unusual malignant breast tumors are well-differentiated subtypes of invasive ductal carcinoma, including mucinous, tubular, medullary and papillary carcinomas, and account for about 10% of malignant breast tumors. They are increasingly being encountered during magnetic resonance imaging (MRI) examinations of the breast. Therefore, breast radiologists should be aware of their appearance on MRI. This review provides an overview of MRI characteristics of a range of unusual tumors (mucinous carcinoma, medullary carcinoma, tubular carcinoma, intraductal papillary carcinoma, intracystic papillary carcinoma and invasive papillary carcinoma), highlighting specific clues for diagnosis and correlating MRI and pathologic features. Many unusual breast tumors exhibit MRI features similar to those of benign or low suspicious lesions (oval shape, well-defined margins, high signal intensity on T2-weighted images, continuous increase kinetics, i.e. type I dynamic curve), leading to a possible misdiagnosis. Nevertheless, an understanding of pathologic features of these tumors, especially tissue content (mucinous, fibrous) and growth pattern, can help to define some specific clues for their diagnosis.

  1. Chemotherapy of malignant bone tumors

    International Nuclear Information System (INIS)

    Long term survival expectoncy for (mostly young) patients with malignant bone tumors have been remarkably optimized during recent years. The 3 main factors most probably are: 1) Optimal primary, interdisciplinary treatment planning. 2) Use of peri or postoperative, intensive adjuvant chemotherapy, including Adriamycine, HD-MTX, Vincristine, Cyclophosphamide or Ifosfamide and recently Cis-Platinum. 3) More adequate postsurgical patient monitoring with earlier diagnosis of potentially localized relapse with aggressive resection policy of focal pulmonary metastases (especially in osteosarcoma patient). Future trends include more appropriate considerations of multiple prognostic variables such as histologic grading localisation and stage of disease, patiente age etc. Therapeutic strategy between centers needs to be standardized and patients with these obviously rare tumors need to be included to hinder therapeutic success or else attribute it to false causes. (orig.)

  2. Skeletal imaging in malignant disease

    International Nuclear Information System (INIS)

    This paper discusses how bone scanning plays a major role in evaluating practically all tumors that originate in or metastasize to bone. A bone scan obtained prior to definitive treatment serves as a baseline for future evaluation and may in a few cases actually redirect therapy. The frequency of follow-up imaging is dictated by the nature of the tumor, stage, symptoms, therapy, and results of previous imaging. Correlative radiographic procedures are often helpful in interpreting the significance of scan findings. Finally, the scan may detect unsuspected pathology in nonosseous systems (e.g., the urinary tract). With the exception of a few tumors such as myeloma, the bone scan is clearly the most sensitive method of early detection of bone involvement by malignant disease

  3. Molecular profiling of endometrial malignancies.

    Science.gov (United States)

    Samarnthai, Norasate; Hall, Kevin; Yeh, I-Tien

    2010-01-01

    Molecular profiling of endometrial neoplasms reveals genetic changes in endometrial carcinomas that support the dualistic model, in which type I carcinomas are estrogen-dependent, low grade lesions and type II carcinomas are nonestrogen dependent and high grade. The molecular changes in type I endometrial carcinomas include mutations in PTEN, PIK3CA, KRAS, and beta-catenin, along with microsatellite instability, whereas type II endometrial carcinomas are characterized by genetic alterations in p53, HER2/neu, p16, and E-cadherin. For endometrial neoplasms with a malignant mesenchymal component, C-MYC mutations and loss of heterozygosity are frequently seen in carcinosarcomas, and a fusion gene, JAZF1/JJAZ1, is distinctive for endometrial stromal sarcoma. In addition, p53 mutations may play an important role in tumorigenesis of undifferentiated endometrial sarcoma. These molecular changes can help in the diagnosis of endometrial neoplasms, as well as form the basis of molecular targeted therapy. PMID:20368795

  4. Amisulpride and Neuroleptic Malignant Syndrome

    Directory of Open Access Journals (Sweden)

    Ming-Che Tu

    2011-10-01

    Full Text Available Neuroleptic malignant syndrome (NMS is a rare but lethal complication of neuroleptics. Its incidence ranges between 0.02% and 3%. Amisulpride, a second generation neuroleptic, was associated with rhabdomyolysis in one report and NMS in 2 reports. Althoughthe precise pathogenesis is still unclear, dopamine receptor blockade is theorized to play acentral role. Conventional presentations include hyperthermia, muscle rigidity, and elevatedcreatine kinase concentrations. However, similar to other second generation neuroleptics,amisulpride induces an atypical form of NMS, which presents with lower degrees of hyperthermia and elevation of creatine kinase than the typical form. This phenomenon makes itdifficult to identify early signs of NMS. This study describes the first case of amisulprideinduced NMS in Taiwan, together with a review of the current knowledge on NMS. In thiscase, the correlation between NMS and amisulpride was categorized as “probable” on theNaranjo adverse drug reaction probability scale

  5. Oncolytic poliovirus against malignant glioma.

    Science.gov (United States)

    Goetz, Christian; Dobrikova, Elena; Shveygert, Mayya; Dobrikov, Mikhail; Gromeier, Matthias

    2011-09-01

    In cancerous cells, physiologically tight regulation of protein synthesis is lost, contributing to uncontrolled growth and proliferation. We describe a novel experimental cancer therapy approach based on genetically recombinant poliovirus that targets an intriguing aberration of translation control in malignancy. This strategy is based on the confluence of several factors enabling specific and efficacious cancer cell targeting. Poliovirus naturally targets the vast majority of ectodermal/neuroectodermal cancers expressing its cellular receptor. Evidence from glioblastoma patients suggests that the poliovirus receptor is ectopically upregulated on tumor cells and may be associated with stem cell-like cancer cell populations and proliferating tumor vasculature. We exploit poliovirus' reliance on an unorthodox mechanism of protein synthesis initiation to selectively drive viral translation, propagation and cytotoxicity in glioblastoma. PVSRIPO, a prototype nonpathogenic poliovirus recombinant, is scheduled to enter clinical investigation against glioblastoma. PMID:21984883

  6. [Robotic surgery for gastroenterological malignancies].

    Science.gov (United States)

    Satoh, Seiji; Suda, Koichi; Kawamura, Yuichiro; Yoshimura, Fumihiro; Taniguchi, Keizo; Uyama, Ichiro

    2012-07-01

    In Japan, the usefulness of robot-assisted surgery using da Vinci surgical system(DVSS)has rapidly become widely acknowledged. At Fujita Health University, DVSS was introduced in 2009. Thus far, 347 patients were treated by DVSS at our institute, including 204 gastroenterological operations. In our department, robot-assisted gastrectomy(RAG, n=111)and robot-assisted esophagectomy(REG, n=26)have been technically standardized. Recently, we reported that both RAG and REG are minimally invasive. Moreover, we showed that the incidence of recurrent nerve palsy by lymphadenectomy was significantly reduced by REG, compared with conventional thoracoscopic esophagectomy. Although robot-assisted surgery is a highly expensive treatment, these results prompt the need for further evaluation of the effectiveness of robot-assisted surgery in the gastroenterological field. Development of a more accurate and less invasive robotic surgery system would contribute to a better quality of life patients with gastroenterological malignancies. PMID:22790036

  7. Malignant tumors of the heart.

    Science.gov (United States)

    Hudzik, Bartosz; Miszalski-Jamka, Karol; Glowacki, Jan; Lekston, Andrzej; Gierlotka, Marek; Zembala, Marian; Polonski, Lech; Gasior, Mariusz

    2015-10-01

    Primary malignant cardiac tumors are rare, and mostly manifest as sarcomas in various types. As non-invasive diagnostic modalities, e.g. echocardiography and magnetic resonance imaging, have become more sensitive, there is a marked increase in the number of patients diagnosed. Nevertheless, most patients die within one year of initial diagnosis, either because of the often asymptomatic presentation of cardiac tumors until advanced disease, or a low index of suspicion on the part of the physician. The presenting symptoms, treatment options and, indeed, prognosis are largely controlled by the tumor's anatomic location. Cardiac sarcomas may present with a variety of symptoms and are known to be great mimickers. A quick diagnosis facilitates the initiation of a proper treatment (surgical resection, adjuvant chemotherapy), which may in turn improve the prognosis. Metastases to the heart are far more common, unfortunately, clinical manifestations are mainly dominated by generalized tumor spread. The article summarizes epidemiology, symptoms, diagnostic modalities, and possible treatment options. PMID:26239627

  8. Fourth ventricular solitary fibrous tumor: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Wang Congli

    2012-07-01

    Full Text Available Abstract Introduction Solitary fibrous tumors of the central nervous system usually present as dura-based masses and clinically resemble meningiomas. There are very few reported cases of intra-ventricular solitary fibrous tumors, particularly in the fourth ventricle. Case presentation Our patient was a 52-year-old African-American man, who presented to our facility with a two-month history of progressive weakness and numbness in all extremities. A computed tomography scan and brain magnetic resonance imaging scan revealed a homogeneous, avidly enhancing 4.5 × 3.7 × 2.7cm fourth ventricular mass, with compression of adjacent medulla and cerebellum and extension into the foramen of Luschka. Our patient underwent a suboccipital craniotomy and resection of the tumor. A histological examination showed a spindle cell neoplasm with prominent collagenized stroma. The neoplastic cells were strongly and diffusely positive for CD34, vimentin and Bcl-2, and negative for S-100, CD99 and epithelial membrane antigen. The molecular immunology Borstel-1 (MIB-1 proliferation index was low (1%. CD31 immunostain highlighted the endothelial cells but the spindle cells were negative. Reticulin stain demonstrated a moderate reticulin network but individual cells were not invested by reticulin fibers. The histological features and immunoprofile was consistent with a solitary fibrous tumor. Conclusions In the central nervous system, solitary fibrous tumors are usually indolent tumors, with only rare examples showing hypercellularity and increased mitotic activity; features that were absent in our patient’s case. We present an uncommon central nervous system neoplasm in a rare location. Although uncommon, solitary fibrous tumors should be included in the differential diagnosis of intra-ventricular tumors in adults.

  9. Osteoarthritis of the hip in fibrous dysplasia of the proximal femur.

    Science.gov (United States)

    Kim, H-S; Im, S B; Han, I

    2015-07-01

    Deformity of the proximal femur in fibrous dysplasia leads to deviation of the mechanical axis of the hip, which may lead to the development of secondary osteoarthritis (OA). This study investigated the prevalence and predisposing factors for the development of OA in patients with fibrous dysplasia of the proximal femur. We reviewed the records of 209 patients from our institutional database with fibrous dysplasia of the proximal femur, investigating possible predisposing factors including patient demographics, the extent of the coxa vara deformity, the presence of peri-articular disease, and the overall burden of skeletal disease. Of the 209 patients, 24 (12%) had radiological evidence of OA in the ipsilateral hip. The prevalence was significantly higher in patients with polyostotic fibrous dysplasia compared with those with monostotic disease (p < 0.001). In a subgroup analysis of patients with polyostotic disease, the extent of deformity (quantified using the neck-shaft angle), and the presence of peri-articular disease (whether in the head of the femur or the acetabulum) were significant predictors of osteoarthritis (neck-shaft angle likelihood ratio (LR) = 0.847 per 1° increase, p = 0.004; presence of lesion in the head of the femur LR = 9.947, p = 0.027; presence of lesion in the acetabulum LR = 11.231, p = 0.014). Our data suggest that patients with polyostotic fibrous dysplasia have a high risk of developing secondary OA of the hips. This risk is higher in patients with peri-articular disease, and those with a more severe deformity of proximal femur. PMID:26130361

  10. Combined Heat Transfer in High-Porosity High-Temperature Fibrous Insulations: Theory and Experimental Validation

    Science.gov (United States)

    Daryabeigi, Kamran; Cunnington, George R.; Miller, Steve D.; Knutson, Jeffry R.

    2010-01-01

    Combined radiation and conduction heat transfer through various high-temperature, high-porosity, unbonded (loose) fibrous insulations was modeled based on first principles. The diffusion approximation was used for modeling the radiation component of heat transfer in the optically thick insulations. The relevant parameters needed for the heat transfer model were derived from experimental data. Semi-empirical formulations were used to model the solid conduction contribution of heat transfer in fibrous insulations with the relevant parameters inferred from thermal conductivity measurements at cryogenic temperatures in a vacuum. The specific extinction coefficient for radiation heat transfer was obtained from high-temperature steady-state thermal measurements with large temperature gradients maintained across the sample thickness in a vacuum. Standard gas conduction modeling was used in the heat transfer formulation. This heat transfer modeling methodology was applied to silica, two types of alumina, and a zirconia-based fibrous insulation, and to a variation of opacified fibrous insulation (OFI). OFI is a class of insulations manufactured by embedding efficient ceramic opacifiers in various unbonded fibrous insulations to significantly attenuate the radiation component of heat transfer. The heat transfer modeling methodology was validated by comparison with more rigorous analytical solutions and with standard thermal conductivity measurements. The validated heat transfer model is applicable to various densities of these high-porosity insulations as long as the fiber properties are the same (index of refraction, size distribution, orientation, and length). Furthermore, the heat transfer data for these insulations can be obtained at any static pressure in any working gas environment without the need to perform tests in various gases at various pressures.

  11. Malignant peripheral nerve sheet tumour of cervix

    Science.gov (United States)

    Akhavan, Ali; Moghimi, Mansour; Zarchi, Mojgan Karimi; Navabii, Hossein

    2012-01-01

    Sarcomas account for less than 1% of malignancies of the uterine cervix. Among them, rhabdomyosarcomas are the ones most frequently reported. Malignant peripheral nerve sheet tumour (MPNST) is very rare. In this paper we present a 53-year-old woman with MPNST of the uterine cervix. PMID:22669864

  12. Expression of Cellular Oncogenes in Human Malignancies

    Science.gov (United States)

    Slamon, Dennis J.; Dekernion, Jean B.; Verma, Inder M.; Cline, Martin J.

    1984-04-01

    Cellular oncogenes have been implicated in the induction of malignant transformation in some model systems in vitro and may be related to malignancies in vivo in some vertebrate species. This article describes a study of the expression of 15 cellular oncogenes in fresh human tumors from 54 patients, representing 20 different tumor types. More than one cellular oncogene was transcriptionally active in all of the tumors examined. In 14 patients it was possible to study normal and malignant tissue from the same organ. In many of these patients, the transcriptional activity of certain oncogenes was greater in the malignant than the normal tissue. The cellular fes (feline sarcoma) oncogene, not previously known to be transcribed in mammalian tissue, was found to be active in lung and hematopoietic malignancies.

  13. Peripheral ameloblastoma with histologically low-grade malignant features of the buccal mucosa: a case report with immunohistochemical study and genetic analysis.

    Science.gov (United States)

    Goda, Hiroyuki; Nakashiro, Kohichi; Ogawa, Ikuko; Takata, Takashi; Hamakawa, Hiroyuki

    2015-01-01

    Peripheral ameloblastoma (PA), a rare and unusual variant of odontogenic tumors, comprises about 1% of all ameloblastomas. PA is an exophytic growth localized to the soft tissues overlying the tooth-bearing areas of the jaws, and the initial diagnosis is often fibrous epulis. PA with histologically low-grade malignant features is extremely rare. We report a case of peripheral ameloblastoma with histologically low-grade malignant features in a 69-year-old woman that presented with a hemorrhage from a tumor on the right buccal mucosa. The tumor was surgically removed by blunt dissection, with no evidence of recurrence after two years and six months. After the case presentation, microscopic and genetic findings are discussed. PMID:25973109

  14. Contact Heat Conductivity Under Conditions of High-Temperature Heat Transfer in Fibrous Heat-Insulating Materials

    Science.gov (United States)

    Grinchuk, P. S.

    2014-03-01

    A mathematical model for calculating the effective heat conductivity of fibrous materials at high temperatures and variable density has been suggested and substantiated. Consideration is focused basically on accounting for heat conduction in the solid phase of a fibrous material. The calculated results were compared with experimental data that demonstrated a good accuracy of the proposed model. The effective heat conductivity of a fibrous heat-insulating material has been calculated as a function of density for a number of temperatures within the range from 200 to 1000°C.

  15. Bilateral fibrous replacement of subclavius muscle in relation to nerve and artery compression of the upper limb

    OpenAIRE

    Georgiev GP; Jelev L

    2009-01-01

    Here, we report an interesting case of bilateral fibrous structures found in the costoclavicular space of a 58-year-old male cadaver during routine anatomical dissection. On the left side, a strong fibrous band extending between the inferior surface of the lateral two-thirds of the clavicle and the coracoid process to the medial end of the first rib was found. On the right side, a similar but thinner structure was discovered. On both sides the variant fibrous structures replacing the subclavi...

  16. Imaging findings of primary retroperitoneal tumors

    Energy Technology Data Exchange (ETDEWEB)

    Hosoki, Takuya; Oka, Takaji [Osaka National Hospital (Japan); Nakamura, Hironobu; Okumura, Akihiko

    1999-03-01

    A retrospective study was conducted in 26 primary retroperitoneal tumors which had been histologically proved (5 leiomyosarcomas, 7 neurogenic tumors, 3 malignant fibrous histiocytomas, 4 liposarcomas, 5 malignant lymphomas, one lipoma, and one synovial sarcoma). The object of the study was to evaluate the usefulness of imaging findings in differentiation of the tumors. In case of neurogenic tumor, its location and CT density provided a better characterization of the tumor. The pattern of spread and relatively homogeneous interior can frequently suggest the likelihood of malignant lymphoma. Lipoma and most types of liposarcoma can be diagnosed on the basis of their lipid element. Apart from these tumors, few retroperitoneal tumors have imaging features that allow them to be histologically distinguished from other types. (author)

  17. Imaging findings of primary retroperitoneal tumors

    International Nuclear Information System (INIS)

    A retrospective study was conducted in 26 primary retroperitoneal tumors which had been histologically proved (5 leiomyosarcomas, 7 neurogenic tumors, 3 malignant fibrous histiocytomas, 4 liposarcomas, 5 malignant lymphomas, one lipoma, and one synovial sarcoma). The object of the study was to evaluate the usefulness of imaging findings in differentiation of the tumors. In case of neurogenic tumor, its location and CT density provided a better characterization of the tumor. The pattern of spread and relatively homogeneous interior can frequently suggest the likelihood of malignant lymphoma. Lipoma and most types of liposarcoma can be diagnosed on the basis of their lipid element. Apart from these tumors, few retroperitoneal tumors have imaging features that allow them to be histologically distinguished from other types. (author)

  18. Malignant infantile osteopetrosis: a case report

    Directory of Open Access Journals (Sweden)

    Gülay Çiler Erda?

    2006-01-01

    Full Text Available Malignant infantile osteopetrosis is a rare autosomal recessive disorder characterized by defective osteoclastic bone resorption. Main findings are hepatosplenomegaly, anemia, and susceptibility to infections, growth failure and generalized osteosclerosis. Although it is possible to diagnose malign infantile osteopetrosis in neonatal period, the exact diagnosis is usually delayed due to the rarity of the disease and nonspecifity of the symptoms. A 33 days old girl admitted to our clinic with vomiting, growth failure, hepatosplenomegaly, anemia, thrombocytopenia and leukocytosis has been diagnosed as malignant infantile osteopetrosis. We want to emphasize the characteristic findings of this rare disease and importance of early diagnosis by presenting this case.

  19. Metastasis to Pleura of Malignant Trichilemmal Tumor

    Directory of Open Access Journals (Sweden)

    Ozgur Katrancioglu

    2013-09-01

    Full Text Available Proliferating trichilemmal tumor arises from the outer layer of the hair follicle and 90% of lesions originate from scalp. They are usually rare skin lesions in elderly women. Although these lesions are benign, local recurrences and metastases are rare, as malignancy may be possible. Three years ago, the complete excision of malignant trichilemmal tumors from the frontal region tumor with malignant pleural metastasis was reported in the case of 62-year-old female patient that presented with a review of the literature due to its rarity.

  20. Molecular genetic study of human malignant gliomas

    International Nuclear Information System (INIS)

    Loss of heterozygosity for loci on chromosome 10 were found in four of 9 (44%) informative cases of malignant gliomas. Deletions on RB1 locus were seen in six of 11 (54%) informative glioblastomas. LOH on chromosome 17p was found in eight of 16 (50%) malignant gliomas, including 2 cases of anaplastic oligodendroglioma. On the basis of the data presented here, it is possible to associate certain molecular abnormalities with malignant gliomas, LOH on chromosome 10, RB1 gene, and 17p. (Author)

  1. [Eye manifestation of extrarenal malignant rhabdoid tumour].

    Science.gov (United States)

    Prívarová, E; Griš?íková, L; Lokaj, M; Vokurková, J; Mazánek, P; Autrata, R

    2014-04-01

    Extrarenal malignant rhabdoid tumour (EMRT) is very rare and aggresive childhood neoplasm with a rapid progression. The prognosis is still very poor with 80 % mortality rate. We report a case of a newborn baby with extrarenal malignant rhabdoid tumour of an upper eyelid. An EMRT was diagnosed based on the histological examination. This case report highlights the clinical presentation, radiological features and difficulty in diagnosis. The purpose is to underline the importance of its inclusion in the differential diagnosis of any aggresive lesion in a child. Key words: malignant rhabdoid tumour, childhood, diagnostic process. PMID:25030315

  2. Primary malignant melanoma of proximal tibia.

    Science.gov (United States)

    Mootha, Aditya K; Bali, Kamal; Kumar, Vishal; Rawall, Saurabh; Saini, Raghav; Dhillon, Mandeep S

    2012-03-01

    Primary malignant melanoma (clear cell sarcoma) of bone is a very rare neoplasm. Although metastatic melanoma to bone is not uncommon, primary malignant melanoma of bone is extremely uncommon. To date, only nine cases have been reported in the English literature. In this report, we present a case of primary malignant melanoma arising from the medial aspect of the proximal tibia in a 26-year-old woman. We treated the patient with above-knee amputation without any chemotherapy or radiotherapy. At final follow-up of 18 months, the patient was free of disease. PMID:22624252

  3. Combined chemotherapy of malignant gliomas

    International Nuclear Information System (INIS)

    A controlled study of 226 age-matched patients with histologically proven grade 3 and 4 supratentorial gliomas with maximum feasible tumour resection, postoperative Karnofsky performance over 50 and minimum survival of 8 weeks compares the results of supportive care (45 cases), high-dose irradiation of 40 to 66 Gy (59 cases), COMP protocol (CCNU, procarbazine, vincristine, methotrexate, prednisone in 15 day cycles-42 cases) and simultaneous irradiation and COMP chemotherapy (80 cases including 30 survivors). Median recurrent-free intervals in the treatment groups (7 to 11.7 months) were significantly longer than after supportive care (4.4 months). Median survival with supportive care (6.7 months) was significantly shorter than after radiation or COMP treatment (11.7 and 12.3 months) and 14.9 to over 19.9 months with combined treatment, where the two-year survival rates were 33 and 67% (for survivors), and the 3-year survival rates 13 to 30%. Toxic side effects of multimodality treatment were more frequent than after chemotherapy. In addition to space-occupying intracranial cysts often simulating tumour recurrence (12%) and rare radiation necrosis, about 15% of long-term survivors developed progressive intellectual dysfunction with brain atrophy, in the absence of tumour regrowth. Despite some promising results of multimodality approaches towards the management of malignant supratentorial gliomas, the overall results are unsatisfactory and need further optimization. (Author)

  4. Staging of pediatric abdominal malignancies

    International Nuclear Information System (INIS)

    The scope of this review is the role of CT in the staging of childhood solid abdominal malignancies. Owing to the limitations of space, only the commonest lesions will be discussed in detail: Wilms' tumor, neuroblastoma, and liver tumors. The TNM staging system has been utilized throughout this monograph. It will not be used in this chapter, however, since in this country different staging systems individualized to each pediatric tumor have been developed. These staging systems take into account the different biology of each tumor and have clear correlations with prognosis and therapeutic programs. The discussion centers almost exclusively on the role of CT in the staging and management of neoplastic processes in children. The information required for staging can sometimes be obtained by other imaging modalities (i.e., ultrasound, excretory urography, etc.) The choice of modality will be strongly influenced by techniques and expertise available as well as by the bias of the institution. An additional factor to be taken into consideration will be the economic factor. Prospective reimbursement will strongly encourage the use of tests that are cost-effective and clinically efficacious

  5. Esophageal malignancy: A growing concern

    Directory of Open Access Journals (Sweden)

    Jianyuan Chai

    2012-01-01

    Full Text Available Esophageal cancer is mainly found in Asia and east Africa and is one of the deadliest cancers in the world. However, it has not garnered much attention in the Western world due to its low incidence rate. An increasing amount of data indicate that esophageal cancer, particularly esophageal adenocarcinoma, has been rising by 6-fold annually and is now becoming the fastest growing cancer in the United States. This rise has been associated with the increase of the obese population, as abdominal fat puts extra pressure on the stomach and causes gastroesophageal reflux disease (GERD. Long standing GERD can induce esophagitis and metaplasia and, ultimately, leads to adenocarcinoma. Acid suppression has been the main strategy to treat GERD; however, it has not been proven to control esophageal malignancy effectively. In fact, its side effects have triggered multiple warnings from regulatory agencies. The high mortality and fast growth of esophageal cancer demand more vigorous efforts to look into its deeper mechanisms and come up with better therapeutic options.

  6. Improved radioimmunotherapy of hematologic malignancies

    International Nuclear Information System (INIS)

    This research project proposes to develop novel new approaches of improving the radioimmunodetection and radioimmunotherapy of malignancies by augmenting retention of radioimmunoconjugates by tumor cells. The approaches shown to be effective in these laboratory experiments will subsequently be incorporated into out ongoing clinical trials in patients. Specific project objectives include: to study the rates of endocytosis, intracellular routing, and metabolic degradation of radiolabeled monoclonal antibodies targeting tumor-associated antigens on human leukemia and lymphoma cells; To examine the effects of lysosomotropic amines (e.g. chloroquine, amantadine), carboxylic ionophores (monensin, nigericin), and thioamides (propylthiouracil), on the retention of radiolabeled MoAbs by tumor cells; to examine the impact of newer radioiodination techniques (tyramine cellobiose, paraiodobenzoyl) on the metabolic degradation of radioiodinated antibodies; to compare the endocytosis, intracellular routing, and degradation of radioimmunoconjugates prepared with different radionuclides (131Iodine, 111Indium, 90Yttrium, 99mTechnetium, 186Rhenium); and to examine the utility of radioimmunoconjugates targeting oncogene products for the radioimmunotherapy and radioimmunoscintigraphy of cancer

  7. Treatment of malignant pleural mesothelioma

    International Nuclear Information System (INIS)

    In Japan, it is predicted that mesothelioma will rapidly increase in the future. Malignant pleural mesothelioma that accounts for approximately 90% of mesothelioma as a whole has a median survival time of approximately nine months which is considered a poor prognosis. As for the treatment of this disease, extrapleural pneumonectomy or pleurectomy/decortication are available for those patients who can be surgically operated on. However, since a complete cure rate is low when only surgical treatment is performed, generally a multimodality treatment is performed wherein chemotherapy and/or radiotherapy are combined. For chemotherapy, a large-scale randomized phase III study demonstrated that a treatment using two agents: pemetrexed, which is a new multitargeted antifolate, and cisplatin is effective. Pemetrexed will be the drug of first choice for mesothelioma in the future. As other treatment methods, chemohyperthermia, treatments using various kinds of cytokines and angiogenesis inhibitors, genetic treatment and photodynamic therapy have been attempted. The current treatment results for this disease are very poor, and there has been a strong demand for establishing an effective treatment method. (author)

  8. RENAL DAMAGE WITH MALIGNANT NEOPLASMS

    Directory of Open Access Journals (Sweden)

    I. B. Kolina

    2015-01-01

    Full Text Available The relationship between renal damage and malignant neoplasms is one of the most actual problems of the medicine of internal diseases. Very often, exactly availability of renal damage determines the forecast of cancer patients. The range of renal pathologies associated with tumors is unusually wide: from the mechanical effect of the tumor or metastases on the kidneys and/or the urinary tract and paraneoplastic manifestations in the form of nephritis or amyloidosis to nephropathies induced with drugs or tumor lysis, etc. Thrombotic complications that develop as a result of exposure to tumor effects, side effects of certain drugs or irradiation also play an important role in the development of the kidney damage. The most frequent variants of renal damage observed in the practice of medical internists (therapists, urologists, surgeons, etc., as well as methods of diagnosis and treatment approaches are described in the article. Timely and successful prevention and treatment of tumor-associated nephropathies give hope for retaining renal functions, therefore, a higher life standard after completion of anti-tumor therapy. Even a shortterm episode of acute renal damage suffered by a cancer patient must be accompanied with relevant examination and treatment. In the caseof transformation of acute renal damage into the chronic kidney disease, such patients need systematic and weighted renoprotective therapy and correct dosing of nephrotoxic drugs.

  9. Combined chemotherapy of malignant gliomas

    Energy Technology Data Exchange (ETDEWEB)

    Jellinger, K.; Volc, D.; Grisold, W.; Flament, H.; Vollmer, R.; Weiss, R. (Krankenhaus der Stadt Wien-Lainz (Austria). Ludwig Boltzmann Inst. fuer Neurobiologie)

    1983-01-01

    A controlled study of 226 age-matched patients with histologically proven grade 3 and 4 supratentorial gliomas with maximum feasible tumour resection, postoperative Karnofsky performance over 50 and minimum survival of 8 weeks compares the results of supportive care (45 cases), high-dose irradiation of 40 to 66 Gy (59 cases), COMP protocol (CCNU, procarbazine, vincristine, methotrexate, prednisone in 15 day cycles-42 cases) and simultaneous irradiation and COMP chemotherapy (80 cases including 30 survivors). Median recurrent-free intervals in the treatment groups (7 to 11.7 months) were significantly longer than after supportive care (4.4 months). Median survival with supportive care (6.7 months) was significantly shorter than after radiation or COMP treatment (11.7 and 12.3 months) and 14.9 to over 19.9 months with combined treatment, where the two-year survival rates were 33 and 67% (for survivors), and the 3-year survival rates 13 to 30%. Toxic side effects of multimodality treatment were more frequent than after chemotherapy. In addition to space-occupying intracranial cysts often simulating tumour recurrence (12%) and rare radiation necrosis, about 15% of long-term survivors developed progressive intellectual dysfunction with brain atrophy, in the absence of tumour regrowth. Despite some promising results of multimodality approaches towards the management of malignant supratentorial gliomas, the overall results are unsatisfactory and need further optimization.

  10. Late sarcoma development after curettage and bone grafting of benign bone tumors

    Energy Technology Data Exchange (ETDEWEB)

    Picci, Piero, E-mail: piero.picci@ior.it [Bone Tumor Center, Istituto Ortopedico Rizzoli, Bologna (Italy); Sieberova, Gabriela [Dept. of Pathology, National Cancer Institute, Bratislava (Slovakia); Alberghini, Marco; Balladelli, Alba; Vanel, Daniel [Bone Tumor Center, Istituto Ortopedico Rizzoli, Bologna (Italy); Hogendoorn, Pancras C.W. [Dept. of Pathology, Leiden University Medical Center, Leiden (Netherlands); Mercuri, Mario [Bone Tumor Center, Istituto Ortopedico Rizzoli, Bologna (Italy)

    2011-01-15

    Background and aim: Rarely sarcomas develop in previous benign lesions, after a long term disease free interval. We report the experience on these rare cases observed at a single Institution. Patients and methods: 12 cases curetted and grafted, without radiotherapy developed sarcomas, between 1970 and 2005, 6.5-28 years from curettage (median 18, average 19). Age ranged from 13 to 55 years (median 30, average 32) at first diagnosis; tumors were located in the extremities (9 GCT, benign fibrous histiocytoma, ABC, and solitary bone cyst). Radiographic and clinic documentation, for the benign and malignant lesions, were available. Histology was available for 7 benign and all malignant lesions. Results: To fill cavities, autogenous bone was used in 4 cases, allograft in 2, allograft and tricalcium-phosphate/hydroxyapatite in 1, autogenous/allograft in 1, heterogenous in 1. For 3 cases the origin was not reported. Secondary sarcomas, all high grade, were 8 osteosarcoma, 3 malignant fibrous histiocytoma, and 1 fibrosarcoma. Conclusions: Recurrences with progression from benign tumors are possible, but the very long intervals here reported suggest a different cancerogenesis for these sarcomas. This condition is extremely rare accounting for only 0.26% of all malignant bone sarcomas treated in the years 1970-2005 and represents only 8.76% of all secondary bone sarcomas treated in the same years. This incidence is the same as that of sarcomas arising on fibrous dysplasia, and is lower than those arising on bone infarcts or on Paget's disease. This possible event must be considered during follow-up of benign lesions.

  11. Late sarcoma development after curettage and bone grafting of benign bone tumors

    International Nuclear Information System (INIS)

    Background and aim: Rarely sarcomas develop in previous benign lesions, after a long term disease free interval. We report the experience on these rare cases observed at a single Institution. Patients and methods: 12 cases curetted and grafted, without radiotherapy developed sarcomas, between 1970 and 2005, 6.5-28 years from curettage (median 18, average 19). Age ranged from 13 to 55 years (median 30, average 32) at first diagnosis; tumors were located in the extremities (9 GCT, benign fibrous histiocytoma, ABC, and solitary bone cyst). Radiographic and clinic documentation, for the benign and malignant lesions, were available. Histology was available for 7 benign and all malignant lesions. Results: To fill cavities, autogenous bone was used in 4 cases, allograft in 2, allograft and tricalcium-phosphate/hydroxyapatite in 1, autogenous/allograft in 1, heterogenous in 1. For 3 cases the origin was not reported. Secondary sarcomas, all high grade, were 8 osteosarcoma, 3 malignant fibrous histiocytoma, and 1 fibrosarcoma. Conclusions: Recurrences with progression from benign tumors are possible, but the very long intervals here reported suggest a different cancerogenesis for these sarcomas. This condition is extremely rare accounting for only 0.26% of all malignant bone sarcomas treated in the years 1970-2005 and represents only 8.76% of all secondary bone sarcomas treated in the same years. This incidence is the same as that of sarcomas arising on fibrous dysplasia, and is lower than those arising on bone infarcts or on Paget's disease. This possible event must be considered during follow-up of benign lesions.

  12. MR imaging of orbital space-occupying lesions

    International Nuclear Information System (INIS)

    Preoperative MR studies were carried out on 11 patients whose diagnoses were confirmed by histologic examination. The pathology of the lacrimal gland tumor and of the orbital varix was predicted preoperatively by the clinical and/or radiological findings. The radiological findings of the malignant fibrous histiocytoma suggested a malignant tumor. By comparison, the preoperative diagnoses of the remaining eight cases were difficult as no characteristic CT findings were useful for differentiating the lesions. Hence, we carried out a retrospective evaluation of the MR images of these lesions, and found that each one of them had characteristic features of signal intensity on T2-weighted images, while the T1-weighted images showed only nonspecific signal intensity. All three pseudotumors were iso- or hypointense relative to extraocular muscles on T2-weighted images. The chief histopathologic feature of these lesions was infiltration of inflammatory cells among the abundant connective fibrous tissue. By contrast, the squamous cell carcinoma and the malignant fibrous histiocytoma, both of which are hypercellular malignant tumors, were hyperintense relative to extraocular muscles, and essentially isointense with orbital fat on T2-weighted images. The cavernous angiomas were hyperintense relative to orbital fat, and almost as isointense as the vitreous humor on T2-weighted images. Histopathologically, the cavernous angiomas exhibited a vascular channel of dilated vessels, lined by a single layer of endothelial cells and interstitial spaces were thought to elongate the T2 relaxation time. On the other hand, intracanalicular aspergillus granulomas are very rare, and our case showed a markedly hypointense mass on T2-weighted MR images. (K.H.)

  13. Treatment of Polyostotic Fibrous Dysplasia of the Thoracic Spine with Intravenous Pamidronate: Result from 9 Months Follow Up.

    Science.gov (United States)

    Lee, Jongjoo; Shin, Hyunchul; Kwon, Young-Jun

    2015-06-01

    Fibrous dysplasia of the spine is very rarely observed. We reported a case of a 57-year-old woman, who presented with neck and bilateral shoulder pain with histologically confirmed fibrous dysplasia, involving the first and second thoracic vertebrae. Clinical and radiological findings were not specific for fibrous dysplasia. The histological biopsy was required for a confirmed diagnosis. Endocrine and metabolic evaluations are required to rule out diseases such as hyperthyroidism, Cushing syndrome and osteomalacia. Fibrous dyplasia can be managed by appropriate medical and surgical treatments based on the patient's neurological status and symptoms. Our patient was given intravenous pamidronate 60mg/day for 3 days. After 9 months, her initial symptoms were improved, but computed tomography scan of the thoracic spine showed no change of the lesions. PMID:26217391

  14. Benign and Malignant Proliferative Fibro-osseous and Osseous Lesions of the Oral Cavity of Dogs.

    Science.gov (United States)

    Soltero-Rivera, M; Engiles, J B; Reiter, A M; Reetz, J; Lewis, J R; Sánchez, M D

    2015-09-01

    Ossifying fibroma (OF) and fibrous dysplasia (FD) are benign, intraosseous, proliferative fibro-osseous lesions (PFOLs) characterized by replacement of normal bone by a fibrous matrix with various degrees of mineralization and ossification. Osteomas are benign tumors composed of mature, well-differentiated bone. Clinical, imaging, and histologic features of 15 initially diagnosed benign PFOLs and osteomas of the canine oral cavity were evaluated. Final diagnoses after reevaluation were as follows: OF (3 cases), FD (4 cases), low-grade osteosarcoma (LG-OSA) (3 cases), and osteoma (5 cases). Histology alone often did not result in a definitive diagnosis for PFOL. OF appeared as a well-circumscribed, radiopaque mass with some degree of bone lysis on imaging. Most lesions of FD showed soft tissue opacity with bone lysis and ill-defined margins. Low-grade OSA appeared as a lytic lesion with a mixed opacity and ill-defined margins. Osteomas were characterized by a mineralized, expansile, well-circumscribed lesion. Although histologic features of PFOLs were typically bland, the lesions diagnosed as LG-OSA had some features of malignancy (eg, bone invasion or a higher mitotic index). Treatment varied widely. Of the 10 dogs with benign PFOL or osteoma with known outcome (10/12), 9 showed either complete response (6/10) or stable disease (3/10) after treatment. Of the 2 dogs with LG-OSA with known outcome, 1 showed complete response after curative intent surgery, but 1 patient had recurrence after partial maxillectomy. Definitive diagnosis of mandibular/maxillary PFOL is challenging via histopathologic examination alone, and accurate diagnosis is best achieved through assimilation of clinical, imaging, and histopathologic features. PMID:25957357

  15. Simple chemical solution coating and gas sensing properties of ?-Fe2O3/chrysotile fibrous composites

    International Nuclear Information System (INIS)

    ?-Fe2O3/chrysotile fibrous composites were prepared by a simple chemical solution coating method for the gas sensitivity improvement of ?-Fe2O3. X-ray diffraction (XRD) and atomic force microscope (AFM) analyses indicate that corundum-type ?-Fe2O3 nanoparticles with a mean particle size ?20 nm are dense and well-proportioned on the surface of chrysotile fibers due to the mechanism that positively charged Fe(OH)3 particles can be adsorbed onto the negatively charged chrysotile fibers in acidic liquids. The fabricated sensor devices were characterized for their electrical and gas sensing properties, it is found that the sensitivities of ?-Fe2O3/chrysotile fibrous composites to H2 and CH4 all increase by ?35% than those of the single ?-Fe2O3 nanoparticles. Such simple coating treatment is an effective way in improving the continuities and gas sensing properties of nanogranular thick films.

  16. Benign fibrous mesothelioma of the pleura: MR study and pathologic correlation

    International Nuclear Information System (INIS)

    Benign fibrous mesothelioma of the pleura is a rare tumor of mesodermal origin. We describe the MR findings in three pathologically proven cases. All three tumors were imaged by MR as well-circumscribed lesions with smooth margins in contact with the pleura, but without chest wall invasion. Their low signal intensity on T1- and T2-weighted sequences reflect their fibrous nature. In one case a pedicle connecting the tumor to the chest wall was visualized on a sagittal MR scan. In two cases gadolinium-enhanced T1-weighted gradient echo sequences revealed intense contrast uptake by the tumor correlated with the intratumoral hypervascularization noted by histologic examination. Although the number of cases presented is small, MR seems to be the most accurate imaging modality in the assessment of the diagnosis. (orig.). With 4 figs., 1 tab

  17. Displasia fibrosa do clivus: relato de caso Fibrous dysplasia of the clivus: case report

    Directory of Open Access Journals (Sweden)

    Asdrubal Falavigna

    2006-06-01

    Full Text Available Relatamos o caso de uma paciente de 43 anos com história de cefaléia crônica e diplopia. O exame neurorradiológico demonstrou aumento de volume e alteração na densidade óssea do clivus. Foi submetida a cirurgia e o exame anatomopatológico evidenciou displasia fibrosa. Foram relatados na literatura outros 14 casos de displasia fibrosa envolvendo o clivus. Discutimos essa rara apresentação da doença segundo o quadro clínico, exames de imagem, histologia e tratamento.We describe the case of a 43 year-old woman with chronic headache and diplopia. The neurorradiologic exam showed volume increase and alteration in the bone density of the clivus. She was submitted to surgery and the anatomopathologic evidenced fibrous dysplasia. Other 14 of about fibrous dysplasia involving the clivus are related in the literature. We discuss clinical aspects, image exams, histology and treatment of this rare presentation of the disease.

  18. Fibrous flexible solid-type dye-sensitized solar cells without transparent conducting oxide

    International Nuclear Information System (INIS)

    We have explored a type of all-solid fibrous flexible dye-sensitized solar cells without transparent conducting oxide based on a CuI electrolyte. The working electrode's substrate is a metal wire. Cu wire counterelectrode is twisted with the dye-sensitized and CuI-coated working electrode. The cell's apparent diameter is about 150 ?m. The cell's current-voltage output depends little on the incident angle of light. A 4-cm-long fibrous cell's open-circuit voltage and short-circuit current generate 304 mV and 0.032 mA, respectively. The interfacial interaction between the two electrodes has a significant influence on the inner charge transfer of the cell

  19. Theoretical study of the fibrous capsule tissue growth around a disk-shaped implant

    KAUST Repository

    Djellouli, Rabia

    2012-08-19

    We analyze the mathematical properties of the fibrous capsule tissue concentration around a disk-shaped implant. We establish stability estimates as well as monotonicity results that illustrate the sensitivity of this growth to the biocompatibility index parameters of the implant. In addition, we prove that the growth of the tissue increases exponentially in time toward an asymptotic regime. We also study the mathematical properties of the solution of the inverse problem consisting in the determination of the values of the biocompatibility index parameters from the knowledge of some fibrous capsule tissue measurements. We prove that this model calibration problem admits a unique solution, and establish a characterization of the index parameters. Furthermore, we demonstrate analytically that such a solution is not continuous with respect to the data, and therefore the considered inverse problem is ill-posed due to the lack of the stability requirement. © 2012 Springer-Verlag.

  20. Mode of action of fibrous amphiboles: the case of Biancavilla (Sicily, Italy)

    Scientific Electronic Library Online (English)

    Giulia, Ballan; Antonella, Del Brocco; Stefano, Loizzo; Alessia, Fabbri; Zaira, Maroccia; Carla, Fiorentini; Sara, Travaglione.

    2014-06-01

    Full Text Available BACKGROUND. The inhalation of fibrous amphiboles can result in pulmonary fibrosis, lung cancer and mesothelioma. Although these fibres have the same disease-causing potential, their different morphologies and chemical composition can determine different biological activities. An unusual cluster of m [...] esothelioma was evidenced in Biancavilla (Sicily) where no inhabitant had been significantly exposed to asbestos. OBJECTIVE. We herein discuss the mechanism of action of amphiboles, focusing on the fibres identified in the study area. RESULTS. Human lung carcinoma cells have been exposed to two different materials: prismatic fluoro-edenite and fibres with fluoro-edenitic composition. Only in the second case, they exhibit features typical of transformed cells, such as multinucleation, prosurvival activity and pro-inflammatory cytokine release. Accordingly, in vivo studies demonstrated that the fibrous sample only could induce a mesotheliomatogenic effect. Conclusions. Fibres with fluoro-edenitic composition behave similarly to the asbestos crocidolite, whose connection with inflammation and lung cancer is well established.

  1. A Network Model for the Effective Thermal Conductivity of Rigid Fibrous Refractory Insulations

    Science.gov (United States)

    Marschall, Jochen; Cooper, D. M. (Technical Monitor)

    1995-01-01

    A procedure is described for computing the effective thermal conductivity of a rigid fibrous refractory insulation. The insulation is modeled as a 3-dimensional Cartesian network of thermal conductance. The values and volume distributions of the conductance are assigned to reflect the physical properties of the insulation, its constituent fibers, and any permeating gas. The effective thermal conductivity is computed by considering the simultaneous energy transport by solid conduction, gas conduction and radiation through a cubic volume of model insulation; thus the coupling between heat transfer modes is retained (within the simplifications inherent to the model), rather than suppressed by treating these heat transfer modes as independent. The model takes into account insulation composition, density and fiber anisotropy, as well as the geometric and material properties of the constituent fibers. A relatively good agreement, between calculated and experimentally derived thermal conductivity values, is obtained for a variety of rigid fibrous insulations.

  2. Welcome to Fibers—A New Open Access Journal for Fibrous Material Science

    Directory of Open Access Journals (Sweden)

    Stephen C. Bondy

    2012-08-01

    Full Text Available Fibers are materials in the form of elongated threads. They can possess elastic features that are relevant to the integrity and bonding of cells. These features also give man-made fibers a wide range of applications. The large ratio of length to width (aspect ratio, which defines fibers, strongly influences their physical and chemical properties. This quality gives them a relatively large surface area, which can lead to powerful tensile and absorptive characteristics, which are remarkably different from, and cannot be predicted by study of the non-fibrous parent materials. An example of this is asbestos, where the toxicity of the material is heavily influenced by its structural anatomy. Distinctive chemical processes can take place on fibrous surfaces that may themselves seem to be chemically inert. Certain commonalities result from the distinctive geometry of fibers, and lie behind the apparently great diversity of fiber types and materials. [...

  3. Mobility of Power-law and Carreau Fluids through Fibrous Media

    CERN Document Server

    Shahsavari, Setareh

    2015-01-01

    The flow of generalized Newtonian fluids with a rate-dependent viscosity through fibrous media is studied with a focus on developing relationships for evaluating the effective fluid mobility. Three different methods have been used here: i) a numerical solution of the Cauchy momentum equation with the Carreau or power-law constitutive equations for pressure-driven flow in a fiber bed consisting of a periodic array of cylindrical fibers, ii) an analytical solution for a unit cell model representing the flow characteristics of a periodic fibrous medium, and iii) a scaling analysis of characteristic bulk parameters such as the effective shear rate, the effective viscosity, geometrical parameters of the system, and the fluid rheology. Our scaling analysis yields simple expressions for evaluating the transverse mobility functions for each model, which can be used for a wide range of medium porosity and fluid rheological parameters. While the dimensionless mobility is, in general, a function of the Carreau number an...

  4. Mesoporous bioactive glass surface modified poly(lactic-co-glycolic acid) electrospun fibrous scaffold for bone regeneration

    OpenAIRE

    Chen, Shijie; Jian, Zhiyuan; Huang, Linsheng; Xu, Wei; Liu, Shaohua; Song, Dajiang; Wan, Zongmiao; Vaughn, Amanda; Zhan, Ruisen; ZHANG, CHAOYUE; Song WU; Hu, Minghua; Li, Jinsong

    2015-01-01

    A mesoporous bioactive glass (MBG) surface modified with poly(lactic-co-glycolic acid) (PLGA) electrospun fibrous scaffold for bone regeneration was prepared by dip-coating a PLGA electrospun fibrous scaffold into MBG precursor solution. Different surface structures and properties were acquired by different coating times. Surface morphology, chemical composition, microstructure, pore size distribution, and hydrophilicity of the PLGA-MBG scaffold were characterized. Results of scanning electro...

  5. Calculation software for efficiency and penetration of a fibrous filter medium based on the mathematical models of air filtration

    OpenAIRE

    Kouropoulos, Giorgos

    2014-01-01

    At this article will be created a software written in visual basic for efficiency and penetration calculation in a fibrous filter medium for given values of particles diameter that are retained in the filter. Initially, will become report of mathematical models of air filtration in fibrous filters media and then will develop the code and the graphical interface of application, that are the base for software creation in the visual basic platform.

  6. Micropatterned coculture of vascular endothelial and smooth muscle cells on layered electrospun fibrous mats toward blood vessel engineering.

    Science.gov (United States)

    Li, Huinan; Liu, Yaowen; Lu, Jinfu; Wei, Jiaojun; Li, Xiaohong

    2015-06-01

    A major challenge in vascular engineering is the establishment of proper microenvironment to guide the spatial organization, growth, and extracellular matrix (ECM) productions of cells found in blood vessels. In the current study, micropatterned fibrous mats with distinct ridges and grooves of different width were created to load smooth muscle cells (SMCs), which were assembled by stacking on vascular endothelial cell (EC)-loaded flat fibrous mats to mimic the in vivo-like organized structure of blood vessels. SMCs were mainly distributed in the ridges, and aligned fibers in the patterned regions led to the formation of elongated cell bodies, intense actin filaments, and expressions of collagen I and ?-smooth muscle actin in a parallel direction with fibers. ECs spread over the flat fibrous mats and expressed collagen IV and laminin with a cobblestone-like feature. A z-stack scanning of fluorescently stained fibrous mats indicated that SMCs effectively infiltrated into fibrous scaffolds at the depth of around 200 ?m. Compared with SMCs cultured alone, the coculture with ECs enhanced the proliferation, infiltration, and cytoskeleton elongation of SMCs on patterned fibrous mats. Although the coculture of SMCs made no significant difference in the EC growth, the coculture system on patterned fibrous scaffolds promoted ECM productions of both ECs and SMCs. Thus, this patterned fibrous configuration not only offers a promising technology in the design of tissue engineering scaffolds to construct blood vessels with durable mechanical properties, but also provides a platform for patterned coculture to investigate cell-matrix and cell-cell interactions in highly organized tissues. PMID:25204306

  7. Composite Films of Arabinoxylan and Fibrous Sepiolite: Morphological, Mechanical, and Barrier Properties

    DEFF Research Database (Denmark)

    Sárossy, Zsuzsa; Blomfeldt, J.O.; Hedenqvist, Mikael S.; Bender Koch, Christian; Sinha Ray, Suprakas; Plackett, David

    2012-01-01

    Hemicelluloses represent a largely unutilized resource for future bioderived films in packaging and other applications. However, improvement of film properties is needed in order to transfer this potential into reality. In this context, sepiolite, a fibrous clay, was investigated as an additive to enhance the properties of rye flour arabinoxylan. Composite films cast from arabinoxylan solutions and sepiolite suspensions in water were transparent or semitransparent at additive loadings in the 2.5...

  8. STUDY ON FIBROUS COMPOSITES BEHAVIOUR IN HYDRODYNAMIC PROCESS OF WINE FILTRATION

    OpenAIRE

    Petronela Nechita; Elena Bobu; Florin Ciolacu; Armand Kontek

    2009-01-01

    This study concerns the implementation and performance evaluation of fibrous composites in sterile filtration of wine. Conditions of preparation were established having in view that the separation of particulate contaminants from liquids by depth filtration is occurring by mechanical entrapment into structural pores and by electrokinetic adsorption, and both retention mechanisms are influenced by various factors. Functional characteristics and behaviour of the filtering composite in industria...

  9. Explicit dynamic simulation of drop weight low velocity impact on carbon fibrous composite panels

    OpenAIRE

    Umar Farooq; Karl Gregory

    2010-01-01

    Finite element computational model was developed to simulate impact behaviour and predict the failure response of carbon fibrous composite panels subjected to low velocity drop-weight impact on the partitioned area where an impactor of flat-nosed tip hits the target. Critical damage regions under impactors’ tips are very complicated phenomenon to study since internal load re-distributes after impact and damage accumulates in through-the-thickness plies. Transformation of mathematical formulat...

  10. A Dumbbell-Shaped Solitary Fibrous Tumor of the Cervical Spinal Cord

    OpenAIRE

    Shin, Dong Ah; KIM, SE HOON; Yoon, Do Heum; Kim, Tai Seung

    2008-01-01

    A 40-year-old Asian female presented with a 2-month history of right shoulder pain and right triceps weakness. MRI revealed an extramedullary, extradural, dumbbell-shaped spinal cord tumor with C6 to C7 iso- and hyperintensity on T1 and T2 weighted imaging, respectively. Histological examination revealed monomorphous spindle cells with a storiform pattern. Immunohistochemistry was positive for CD34, CD99, and negative for EMA, SMA, and S100; solitary fibrous tumor (SFT) was confirmed.

  11. Comparison of Sporadic Sclerotic Fibroma and Solitary Fibrous Tumor in the Oral Cavity

    OpenAIRE

    Lee, Ju-Han; An, Jung-Suk; Lee, Eung Seok; Kwon, Soon-Young; Kim, Young-Sik

    2007-01-01

    Sporadic sclerotic fibroma (SF) and solitary fibrous tumor (SFT) arising in the oral cavity are very rare. In this report, we describe two cases of oral pathology, one involving SF and the other involving SFT. Both cases presented with well-circumscribed, firm nodules with similar gross findings. However, the histologic findings of the SF and SFT showed rather distinct features. The SF was composed of hyalinized sclerotic collagen bundles arranged in a whorled pattern, whereas the SFT was for...

  12. Fibrous based materials in sustainable civil and architectural applications – a review

    OpenAIRE

    Fangueiro, Raúl; Rosado, Katherine; Guise, Catarina; Rebelo, Rita

    2011-01-01

    The aim of this review paper is to present a survey on fibrous materials used in key areas of construction and architectural sectors. Here are highlighted conceptual challenges involved in some of the applications trying to define what we call a “green” building. The main applications reviewed are concrete reinforcement, structural health monitoring, insulation, and architectural membranes. On the other hand, tendencies in the area such as sustainability, weight reduction, enhanced durability...

  13. Retroperitoneal solitary fibrous tumor of the pelvis with pollakiuria: a case report

    OpenAIRE

    Tsushimi Takaaki; Yagi Takaharu; Tomozawa Naobumi; Ohnishi Hiromi

    2012-01-01

    Abstract Background Solitary fibrous tumor (SFT) is rare soft tissue tumor, and it occurs most commonly in the pleura. Retroperitoneal SFT is generally found by palpable mass or abdominal distention. Here we report a case of SFT presenting pollakiuria. Case presentation A 64-year-old man was referred to our hospital for pollakiuria. Contrasted-enhanced computed tomography revealed a heterogeneously enhanced pelvic tumor of approximately 10?×?8?×?7?cm. Invasion of the surrounding organs, dista...

  14. Surgical resection using retroperitoneal approach for solitary fibrous tumor in the pelvis

    OpenAIRE

    SHOJI, SUNAO; NAKANO, MAYURA; YAMAMOTO, SHINYA; OKADA, NAOTAKA; NAGATA, YOSHIHIRO; SEKIDO, YASUTOMO; TERAYAMA, HAYATO; ITO, Masahiro; UCHIDA, TOYOAKI

    2011-01-01

    This report concerns a case of solitary fibrous tumor (SFT) for which surgical resection was performed using a retroperitoneal approach. A 41-year-old man was referred to our hospital with urinary retention. Abdominal ultrasound sonography (US) and computed tomography (CT) showed a hypervascular mass lesion in the pelvis. Transrectal biopsy showed SFT. Surgical resection was carried out using a retroperitoneal approach and preserving the neural network related to urinary and erectile function...

  15. Clinicopathological findings in a case series of extrathoracic solitary fibrous tumors of soft tissues

    OpenAIRE

    Steinau Hans-Ulrich; Steinstraesser Lars; Langer Stefan; Lehnhardt Marcus; Daigeler Adrien; Mentzel Thomas; Kuhnen Cornelius

    2006-01-01

    Abstract Background Solitary fibrous tumors (SFT) represent a rare entity of soft tissue tumors. Previously considered being of serosal origin and solely limited to the pleural cavity the tumor has been described in other locations, most particularly the head and neck. Extrathoracic SFT in the soft tissues of the trunk and the extremities are very rare. Nine cases of this rare tumor entity are described in the course of this article with respect to clinicopathological data, follow-up and trea...

  16. Proof of the patent subcutaneous fibrous tract in children with V-P shunt malfunction.

    Science.gov (United States)

    Kazan, S; Açikba?, C; Rahat, O; Tuncer, R

    2000-06-01

    A connective tissue sheath that forms around the peritoneal catheter of silicone ventriculo-peritoneal (V-P) shunt tubing is quite often observed in children with V-P shunts. However, proof of the passage of cerebrospinal fluid (CSF) through these sheaths has been reported in only one published study to date. We present four cases associated with chronic malfunction of the V-P shunt peritoneal catheter. In these cases, CSF passage through the subcutaneous fibrous tract, which had a pericatheter connective tissue sheath, was demonstrated around the V-P shunt peritoneal catheter. In the first case the patient suffered intermittent headache attacks over a long period of time; abdominal migration of the peritoneal catheter was detected. The second patient, who had been asymptomatic in the follow-up period with an outgrown peritoneal catheter, was admitted with acute hydrocephalus symptoms. A peritoneal catheter disconnection was detected in another patient, who had had multiple shunt revisions previously. In the last case, an obstruction of the peritoneal catheter was detected. The existence of the subcutaneous fibrous tract and its function were demonstrated by radio-opaque shuntogram in two cases and radionuclide shuntogram in the other two cases. In all four cases V-P shunt revision was performed. Within this study, the possible passage of CSF through a fibrous tract in cases of migration, outgrowth, disconnection or obstruction of the peritoneal shunt catheter was demonstrated. In conclusion, patients with shunt malfunction with a well-grown pericatheter fibrous sheath who are either asymptomatic or minimally symptomatic and show no evidence of active ventricular dilatation on their cranial CT scan should not be regarded as having arrested hydrocephalus until radio-opaque or radionuclide shuntogram studies have been done. PMID:10933230

  17. Non-standard test methods for long-fibrous reinforced composite materials

    OpenAIRE

    L. A. Dobrza?ski; A.J. Nowak; W. B?a?ejewski; R. Rybczy?ski

    2011-01-01

    Purpose: The investigations serve as comparative verification of silicone-aramid material designed for oesophageal prosthesis.Design/methodology/approach: In this work, non-standard research techniques, particularly designated for comparative tests of long-fibrous composite materials, are presented. Those tests are carried out on equipment similar to so called NOL rings test and pressure tests using rubber as a working mediumFindings: During interpretation of pressure tests results according ...

  18. Cell Free Xanthan Gum Production Using Continuous Recycled Packed Fibrous-bed Bioreactor-membrane

    OpenAIRE

    Rosalam, S.; D. Krishnaiah; Bono, A

    2008-01-01

    Although the xanthan gum has been produced as a commercial commodity, the biomass isolation and its recovery are still challenging. This study revealed the xanthan gum production by fermentation of Xanthomonas campestris DSMZ using glucose as a carbon source in an immobilised batch and a continuous recycled packed fibrous-bed bioreactor-membrane (CRPBFBM). The pure cotton fibre was used to immobilise the microbial cell biomass and to isolate from the liquid phase containing medium and xantha...

  19. Fibrous active carbon based adsorbents for the purification of liquid media polluted by radionuclides

    International Nuclear Information System (INIS)

    There has been considered the influence of surface state and pore structure, as well as type of impregnating additives and conditions of their introduction, on the properties of modified carbon fibrous sorbents for purification of liquid media concurrently from radionuclides and harmful organic impurities. With the aid of a model system there has been shown high efficiency of modified sorbent containing iron (3) ferrocyanide in the extraction of cesium and strontium radioisotopes from biological media

  20. Dental Perspectives in Fibrous Dysplasia and McCune-Albright Syndrome

    OpenAIRE

    Akintoye, Sunday O; Boyce, Alison M; Collins, Michael T.

    2013-01-01

    McCune-Albright syndrome (MAS) is a rare multisystem disorder characterized by the triad of polyostotic fibrous dysplasia (PFD), endocrine disorders and café-au-lait skin pigmentation. Ninety percent of MAS patients have FD lesions in the craniofacial area, resulting in significant orofacial deformity, dental disorders, bone pain and compromised oral health. Maxillo-mandibular FD is also associated with dental developmental disorders, malocclusion, and high caries index. There is limited data...

  1. Solitary Fibrous Tumor of The Lumbar Spine: Case Report and Review of The Literature

    OpenAIRE

    Xian-Wei ZENG; Li, Bin; Wang, Xiao-Qiang

    2012-01-01

    Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm that typically arises in the pleural cavity. The lesion located in the spinal region is very uncommon. SFT resembles other spindle cell neoplasms of the spine and may be an unrecognized entity if not routinely considered in the differential diagnosis of spinal neoplasms. The authors report an unusual extradural location of lumbar SFT. A 63-year-old male presented with a six-month history of progressive weakness and numbness on ...

  2. Inhibition of Fibrous Adhesion Formation in the Temporomandibular Joint of Tenascin-C Knockout Mice

    OpenAIRE

    Shinohara, Y.; Okamoto, K.; Goh, Y.; Kiga, N.; I. Tojyo; Fujita, S.

    2014-01-01

    Tenascin-C (TNC) is a large hexameric extracellular matrix glycoprotein that is expressed in developing organs and tumors. It has been reported that TNC is expressed in inflamed synovial membranes and deformed discs of temporomandibular joint (TMJ) disorder. However, the role of TNC in TMJ is not fully known. In this study, the role of TNC in fibrous adhesion formation of TMJ was examined using TNC knockout (TNCKO) mice. Hypermobility was produced by excessive mouth opening method on the TMJ ...

  3. Looking for the minimum efficiency of fibrous air filters during their service life

    OpenAIRE

    Tronville, Paolo Maria

    2012-01-01

    Electret fibrous air filter media achieve high efficiencies while maintaining low air flow resistance by incorporating electrostatic charges on their fibers. However, captured ultrafine particles reduce this electrostatic enhancement. It is important to evaluate the behavior of such media when their electrostatic enhancement has been completely suppressed, leaving only "mechanical" effects such as sieving, impaction, interception and diffusion. Existing standards EN779:2002 and ASHRAE 52.2-20...

  4. An inverse method to obtain porosity, fibre diameter and density of fibrous sound absorbing materials

    OpenAIRE

    Alba Fernández, Jesús; REY TORMOS, ROMINA MARÍA DEL; Ramis Soriano, Jaime; Arenas, Jorge P.

    2011-01-01

    Characterization of sound absorbing materials is essential to predict its acoustic behaviour. The most commonly used models to do so consider the flow resistivity, porosity, and average fibre diameter as parameters to determine the acoustic impedance and sound absorbing coefficient. Besides direct experimental techniques, numerical approaches appear to be an alternative to estimate the material's parameters. In this work an inverse numerical method to obtain some parameters of a fibrous mater...

  5. Clinical and Radiological Observations in a Case Series of 26 Patients with Fibrous Dysplasia

    DEFF Research Database (Denmark)

    Thomsen, Malissa Dawn; Rejnmark, Lars

    2014-01-01

    Fibrous dysplasia (FD) is a rare disease caused by a sporadic postzygotic missense mutation that leads to abnormal fibroblast proliferation, defective osteoblast differentiation, and increased bone resorption. It may affect one or several bones. Both the mono-ostotic and polyostotic types may be associated with hyperfunctional endocrinopathies and hyperpigmentation of the skin (café-au-lait spots) in the so-called McCune-Albright syndrome (MAS). Due to its rarity, only a few case series are avai...

  6. Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells

    OpenAIRE

    Riminucci, Mara; Robey, Pamela Gehron; Saggio, Isabella; Bianco, Paolo

    2010-01-01

    Activating mutations of the GNAS gene, which causes fibrous dysplasia of bone (FD), lead to remarkable changes in the properties of skeletal progenitors, and it is these changes that mediate the pathological effect of this gene on bone. Mutated skeletal stem cells lose the ability to differentiate into adipocytes, and to maintain in situ, and transfer heterotopically, the hematopoietic microenvironment, leading to abnormal bone marrow histology in FD. They over-express molecular effectors of ...

  7. Isolated malignant melanoma metastasis to the pancreas

    DEFF Research Database (Denmark)

    Larsen, Anne K; Krag, Christen; Geertsen, Poul; Jakobsen, Linda P

    2013-01-01

    SUMMARY: Malignant melanomas rarely develop isolated pancreatic metastases. We describe a unique patient who is still alive 22 years following an isolated pancreatic melanoma metastasis, and we review the sparse literature in the field.

  8. Benign fracture versus malignant vertebral body infiltration

    International Nuclear Information System (INIS)

    MR imaging capabilities in differentiating marrow signal alterations seen in benign vertebral body compression fractures from those of malignant vertebral infiltration were assessed. Thirty-six patients, including 15 with posttraumatic vertebral compression fractures of known age, and 21 with malignant bone lesions, were imaged with MR. MR spine imaging (1.5 T) was performed with routine spin-echo sequences as well as inversion recovery (STIR), gradient-echo scans (GRASS), and chemical shift images (selective saturation technique) to obtain fat and water scans. Fat/water images enhanced differentiation between benign and malignant signal alterations. In general, patients with malignancy showed abnormal diffuse low signal intensity on fat images and corresponding increased signal on water images. Benign compression fractures showed variable patterns of signal alteration on fat/water images depending on fracture age. Old fractures showed persistent fat signal. Only very acute traumatic fractures showed increased signal on water images

  9. Young Cancer Survivors Often Develop New Malignancies

    Science.gov (United States)

    ... html Young Cancer Survivors Often Develop New Malignancies Teens, young adults who received radiation treatment appear at higher ... 6, 2015 TUESDAY, Oct. 6, 2015 (HealthDay News) -- Teen and young adult cancer survivors are at increased risk for ...

  10. Recent cases of radium-induced malignancy

    International Nuclear Information System (INIS)

    Five cases of malignant disease attributed to radium in patients with measured body burdens have been discovered since 1974, including three bone sarcomas and two mastoid carcinomas. Pertinent findings in these cases are summarized here

  11. Transgenic mouse model for skin malignant melanoma.

    Science.gov (United States)

    Kato, M; Takahashi, M; Akhand, A A; Liu, W; Dai, Y; Shimizu, S; Iwamoto, T; Suzuki, H; Nakashima, I

    1998-10-01

    We report here on a novel metallothionein-I (MT)/ret transgenic mouse line in which skin melanosis, benign melanocytic tumor and malignant melanoma metastasizing to distant organs develop stepwise. The process of tumor development and its malignant transformation in this line may resemble that of the human giant congenital melanocytic nevus that is present at birth and that frequently gives rise to malignant melanoma during aging. We observed an increase in the expression level and activity of the ret transgene during the disease progression. That increase in transgene expression accompanied an activation of mitogen-activated protein kinases (MAPKs) and c-Jun as well as matrix metalloproteinases. These results suggest that progressive dysregulation of the expression level of the ret transgene might play a crucial role in the malignant transformation of melanocytic tumors developed in the MT/ret transgenic mouse line. PMID:9778055

  12. ACTINOMYCES NAESLUNDII IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES

    Directory of Open Access Journals (Sweden)

    S. H. Rasa J. V Yusefi

    2006-09-01

    Full Text Available Mycotic infections have been commonly encountered in patients with hematological malignancies. The current study seeks the prevalence of actinomycete infection in patients suffering from blood cells malignancies. A hundred and fifty patients with some kinds of blood cells dyscrasia who underwent the bone marrow aspiration were recruited. In addition to the diagnostic work up, samples were examined for the presence of actinomycete infections. Twenty one samples were positive for actinomycete infections. All of them were infected by Actinomyces naeslundii. All the positive patients were categorized in malignant groups, acute myelocytic leukemia, chronic myelocytic leukemia, and lymphoma and myelodysplastic syndrome. High incidence of actinomycete infections in the present study population was interesting. These results can also be suggestive of a pre-malignancy role for the actinomycosis.

  13. Recent cases of radium-induced malignancy

    International Nuclear Information System (INIS)

    Three cases of malignant disease attributed to radium in patients with measured body burdens have been observed since 1978 - one paranasal sinus carcinoma, one mastoid carcinoma, and one fibrosarcoma of bone. These cases are summarized here. 4 references

  14. Targeting cell cycle regulators in hematologic malignancies

    OpenAIRE

    Aleem, Eiman; Arceci, Robert J

    2015-01-01

    Hematologic malignancies represent the fourth most frequently diagnosed cancer in economically developed countries. In hematologic malignancies normal hematopoiesis is interrupted by uncontrolled growth of a genetically altered stem or progenitor cell (HSPC) that maintains its ability of self-renewal. Cyclin-dependent kinases (CDKs) not only regulate the mammalian cell cycle, but also influence other vital cellular processes, such as stem cell renewal, differentiation, transcription, epigenet...

  15. Epidemiology of Smoking-Related Malignancies

    OpenAIRE

    Spinelli, John J

    1990-01-01

    It is well known that tobacco use is the major single cause of cancer mortality. Cigarette smokers have increased risk for cancer of the lung, bladder, oral cavity and pharynx, pancreas, kidney, larynx, and esophagus. Although smoking is the primary risk factor for several of the malignancies, each tumour site has other known or suspected risk factors. The author describes the smoking association for each tumour site and reviews other risk factors for these smoking-related malignancies.

  16. Malignant melanoma in children and adolescents

    OpenAIRE

    Berg, Peter

    2003-01-01

    The aim of the work reported in the present thesis was to investigate malignant melanoma in children and adolescents. Through epidemiological studies, we wished to investigate incidence, clinical factors and prognosis and to study the records. Also studied were etiological factors such as phototherapy in newborns and the effect of congenital nevi on the risk of malignant melanoma. Finally a genetic study of this age group was conducted using immunohistochemical analysis. ...

  17. Multiple cutaneous malignancies in xeroderma pigmentosum

    OpenAIRE

    Mohanty Prasenjeet; Mohanty L; Devi B

    2001-01-01

    A case of xeroderma pigmentosum with multiple cutaneous malignancies is being reported. The case presented with freckles, letigens, and keratosis, a non-tender ulcerated nodular lesion on the nose, a nodular ulcerated lesion on the right outer canthus of the conjunctiva, and a nodular growth which developed on the right cheek which on histopathology was found to be squamous cell cercinoma, basal cell carcinoma and malignant melanoma respectively.

  18. Multiple cutaneous malignancies in xeroderma pigmentosum

    Directory of Open Access Journals (Sweden)

    Mohanty Prasenjeet

    2001-01-01

    Full Text Available A case of xeroderma pigmentosum with multiple cutaneous malignancies is being reported. The case presented with freckles, letigens, and keratosis, a non-tender ulcerated nodular lesion on the nose, a nodular ulcerated lesion on the right outer canthus of the conjunctiva, and a nodular growth which developed on the right cheek which on histopathology was found to be squamous cell cercinoma, basal cell carcinoma and malignant melanoma respectively.

  19. Difficulties in diagnosing neuroleptic malignant syndrome.

    OpenAIRE

    Monica S. Zolezzi; Abdullah M. Al-Hathloul

    2002-01-01

    ABSTRACT This report describes a recent case of neuroleptic malignant syndrome, a rare adverse effect of antipsychotic medications. Assessment of the neuroleptic malignant syndrome was carried out by using the Naranjo Algorithm Probability Scale which resulted in a highly probable reaction to haloperidol. The difficulties in establishing the diagnosis in this patient lead to late intervention resulting in a slow recovery and prolonged hospitalization. Our objective in this presentation is ...

  20. Primary tubercular mastitis masquerading as malignancy

    OpenAIRE

    Prathima, S; Kalyani, R.; Parimala, S.

    2014-01-01

    The significance of primary tubercular mastitis is due to rare occurrence and often overlooked and misdiagnosed as pyogenic breast abscess or malignancy. Despite the high incidence of tuberculosis in India, reports of breast tuberculosis among the total number of mammary conditions varies between 0.64% and 3.59%. We report a case of a 35-year-old lady with breast lump of 3 months duration, which simulated malignancy on clinical examination but fine needle aspiration cytology revealed granulom...