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Sample records for malignant fibrous histiocytomas

  1. Calvarial malignant fibrous histiocytoma

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    Chhabra R

    2004-07-01

    Full Text Available Primary malignant fibrous histiocytoma (MFH of the central nervous system (CNS is uncommon. We report cases of two young patients of MFH arising from the cranial meninges and involving the adjacent skull and scalp. There was infiltration of the brain in one case. Both the lesions were excised and primary scalp repair was performed.

  2. Calvarial malignant fibrous histiocytoma

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    Chhabra R; Gupta S; Manjunath Prasad K; Gupta D; Vasishta R; Sharma R.; Khosla V

    2004-01-01

    Primary malignant fibrous histiocytoma (MFH) of the central nervous system (CNS) is uncommon. We report cases of two young patients of MFH arising from the cranial meninges and involving the adjacent skull and scalp. There was infiltration of the brain in one case. Both the lesions were excised and primary scalp repair was performed.

  3. Malignant fibrous histiocytoma of bone

    International Nuclear Information System (INIS)

    This is the case history of a 19-year old patient in whom a malignant tumour was found 8 years after radiotherapy of Hodgkin's disease. After some classification difficulties the tumour, which was located in the radiation-exposed proximal region of the humerus, was identified as a malignant fibrous histiocytoma. (orig./AJ)

  4. Primary malignant fibrous histiocytoma of the mediastinum.

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    Morshuis, W. J.; Cox, A. L.; Lacquet, L K; Mravunac, M.; Barentsz, J.O.

    1990-01-01

    A malignant fibrous histiocytoma of the mediastinum was successfully treated by surgery and radiotherapy. Magnetic resonance imaging was able to show the site of invasion, the two different components of the tumour, and the blood supply.

  5. Malignant fibrous histiocytoma of the mediastinum.

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    Aggarwal, P.; S. K. SHARMA; Dey, A.B.; Chattopadhyay, T K; Mathur, M

    1989-01-01

    A case of malignant fibrous histiocytoma of the mediastinum presenting with unusual features of fever and leucocytosis is reported. This is the youngest patient reported in the literature who had this tumour in the mediastinum.

  6. A case of intracranial malignant fibrous histiocytoma

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    Amir Hossein Sarrami

    2011-01-01

    Full Text Available We describe a case of intracranial malignant fibrous histiocytoma which had infiltrated pons, cerebellum and basal surface of left temporal lobe without any visible mass. The patient presented with a sudden loss of consciousness and vomiting. Clinical findings, laboratory tests, imaging and examination of the cerebrospinal fluid tended to establish the diagnosis of an infectious condition than a malignancy. Without any response to the antibiotics and with a progressive deterioration of neurologic and mental condition, the patient died after 20 days. In the autopsy, histological and immunohistochemical study of the brain revealed the diagnosis of malignant fibrous histiocytoma (MFH.

  7. Malignant fibrous histiocytoma with skeletal involvement

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    Takechi,Hideo

    1978-10-01

    Full Text Available Malignant fibrous histiocytoma of soft part is rather common but malignant fibrous histiocytoma of the bone is rarely encountered clinically. Authors present five cases of malignant fibrous histiocytoma with skeletal involvement and discuss their clinical course, x-ray findings and histological features. This tumor has marked tendency for local recurrence and metastasis. Other bone tumors such as giant cell tumor, aneurysmal bone cyst, non ossifying fibroma, osteosarcoma, fibrosarcoma of bone and metastatic cancer can be excluded by several characteristic findings observed in x-rays as well as histopathological features. All information on the patient should be carefully analysed, because it is difficult to decide whether bone involvement is primary or secondary. Four out of five cases definitely originated within the bone.

  8. MRI of intracranial meningeal malignant fibrous histiocytoma

    International Nuclear Information System (INIS)

    We describe the CT and MRI findings in a patient with primary intracranial meningeal malignant fibrous histiocytoma (MFH). CT delineated the anatomical relations and MRI aided in tissue characterisation. To our knowledge, this is the first report describing the MRI findings in primary intracranial meningeal MFH. (orig.). With 1 fig

  9. Hepatic malignant fibrous histiocytoma of imaging characteristics

    International Nuclear Information System (INIS)

    Objective: To enhance the understanding of imaging characteristics of hepatic malignant fibrous histiocytoma. Methods: Four cases of hepatic malignant fibrous histiocytoma proven by pathology were examined by means of CT (n=4), MRI (n=2), and angiography (n=1). Results: All tumors of the four patients were located in the right lobe of the liver. The marginal contours were irregular. The tumors extended to the liver capsule in three patients. On CT, all tumors were hypodense (28-36 HU) on plain scan compared with surrounding liver parenchyma. Plaque-like slight hyper dentisites were seen in two patients. After contrast injection, the solid portion of the mass showed mild enhancement (52-70 HU) in arterial phase, and moderate enhancement in venous phase (75-98 HU). Obvious nonenhanced necrotic areas were seen in all cases. On MR images, the main signal intensity of the mass was hypointense on T1-weighted imaging compared with the adjacent liver. Plaque-like hyper intensities were seen in one patients. The intensity of the masses were higher than that of the liver on T2-weighted images. Angiography of one patient showed displacement of hepatic vasculature by the mass on arterial phase and irregular tumor staining was seen on parenchyma phase. Conclusion: The primary imaging character of hepatic malignant fibrous histiocytoma is apparently invasive with unclear border and massive necrosis in the central part, and intratumoral bleeding is common. (authors)

  10. Postirradiation sarcoma (malignant fibrous histiocytoma) following cervix cancer

    International Nuclear Information System (INIS)

    A case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 11 years following postoperative external beam radiation therapy (7,000 rad) for carcinoma of the cervix. Reports of postirradiation malignant fibrous histiocytoma are rare, and the occurrence of this neoplasm following treatment for cervix cancer has not previously been described. The literature concerning postirradiation bone and soft tissue sarcomas is briefly reviewed, with special attention to malignant fibrous histiocytomas. (author)

  11. Post-radiation cranial malignant fibrous histiocytoma studied by CT

    International Nuclear Information System (INIS)

    A 37-year-old woman presented with a proven case of malignant fibrous histiocytoma of the skull. This is thought to be a rare complication of post-radiation to a chromophobe adenoma which was treated by radiotherapy nine years previously. The radiation dose given to the sella region after the removal of the chromophobe adenoma was 4500 cGy

  12. Post-radiation cranial malignant fibrous histiocytoma studied by CT

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    Romero, F.J.; Ortega, A.; Ibarra, B.; Piqueras, J.; Rovira, M.

    1989-03-01

    A 37-year-old woman presented with a proven case of malignant fibrous histiocytoma of the skull. This is thought to be a rare complication of post-radiation to a chromophobe adenoma which was treated by radiotherapy nine years previously. The radiation dose given to the sella region after the removal of the chromophobe adenoma was 4500 cGy.

  13. A case of postirradiated malignant fibrous histiocytoma of the vagina

    International Nuclear Information System (INIS)

    An unusual case of postirradiated malignant fibrous histiocytoma of the vagina in a 72-year-old female is reported. The tumor occurred in the radiation field 30 years after radical hysterectomy and preoperative radiation therapy (radium 5,200 mgh) for squamous cell carcinoma of the uterine cervix. She had been disease free for 30 years until she noticed a large mass in the vagina. Cytological study showed mainly two types of non-epithelial malignant cells; spindle-shaped fibroblast-like cells and histiocyte-like cells. Bizarre mono or multinucleated giant cells were often observed. The operative specimen revealed an arrangement composed of short or long spindle cells and vacuolated mononucleated and large multinucleated cells. The diagnosis was comfirmed by immunohistological and ultrastructural study. We have reviewed the literature on malignant fibrous histiocytoma occurring after radiation for cervical carcinoma. (author)

  14. Adult paratesticular malignant fibrous histiocytoma treated with surgery, systemic chemotherapy and postoperative adjuvant radiotherapy

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    Schmitz Matthew

    2006-01-01

    Full Text Available Paratesticular malignant fibrous histiocytoma is an extremely rare malignancy of the scrotum. This malignancy has rarely been described in the literature and scant information exists on the optimal management of this cancer. We present here a case of a 57-year-old man with a diagnosis of high-grade malignant fibrous histiocytoma of the left intrascrotal region who underwent radical orchiectomy, systemic chemotherapy and postoperative radiotherapy.

  15. MALIGNANT FIBROUS HISTIOCYTOMA OF THE PENIS A CASE REPORT AND REVIEW OF THE LITERATURE

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    Tufan Tarcan

    2009-01-01

    Full Text Available Penile malignant fibrous histiocytoma is an extremely rare tumor. To the best of our knowledge, we present here the fifth primary malignant fibrous histiocytoma of the penis. The patient presented with lung metastasis which initially responded well to systemic chemotherapy with Adriamycin and Ifosfamide, but recurred soon after. The local lesion did not respond to chemotherapy and the patient had to undergo a palliative penectomy. The disease progressed rapidly and the patient died one year after the diagnosis.

  16. Malignant fibrous histiocytoma of the mandible and the infratemporal fossa鈥擜 case report

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    Joshi, Himani; Rayappa, Chinna Swamy

    2011-01-01

    Malignant fibrous histiocytoma is a sarcoma which commonly occurs in the soft tissues, joints and tendons of the extremities of adults but its occurrence in the oral and maxillofacial region is very rare. We present a rare case of malignant fibrous histiocytoma of the mandible with recurrence in the infratemporal fossa after surgery and radiotherapy. Patient underwent second surgery and complete tumor excision with minimal loss of function was achieved. Patient survived 8 years after surgery ...

  17. Malignant fibrous histiocytoma of sternum: an unusual cause of pyrexia of undetermined origin.

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    Grieco, A.; Caputo, S; Silvestri, E.; Caradonna, P.; Bertoli, A.; Greco, A V

    1989-01-01

    Malignant fibrous histiocytoma of the bone is a very rare tumour mainly affecting long bones, and the most common presenting symptom is local pain. A case of malignant fibrous histiocytoma presenting with pyrexia of undetermined origin and arising in the sternum, a localization not previously described, is reported. The patient died with septic shock after multi-drug chemotherapy including high dose methotrexate treatment with citrovorum factor rescue.

  18. MR imaging findings of malignant fibrous histiocytoma of bone

    International Nuclear Information System (INIS)

    The purpose of this study is to assess magnetic resonance (MR) imaging findings of malignant fibrous histiocytoma (MFH) of bone and to evaluate the role of contrast-enhanced MR imaging in the diagnosis of bone MFH. MR imagings of pathologically proven bone MFH in ten patients were reviewed. Enhanced study was also performed with Gd-DTPA. The MR images were evaluated for signal intensity, homogeneity, marginal definition, presence of internal septation, cortical destruction, soft tissue extension, joint involvement and contrast enhancement. Tumors showed iso- or slightly high signal intensity to muscle on T1-weighted images and heterogeneously high signal intensity on T2-weighted images. Four cases showed poor-marginated border on T2-weighted images and four cases had internal septa. Eight of nine patients with intravenous administration of Gd-DTPA showed contrast enhancement, five were heterogeneous and three were homogeneous. All cases showed cortical destruction and soft tissue extension. Five cases showed joint involvement. Bone MFH showed similar MR imaging findings of soft tissue MFH or other malignant bone tumors, but joint involvement was suggestive finding of bone MFH

  19. Benign Fibrous Histiocytoma

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    Pushpa Varma

    2014-01-01

    Full Text Available Fibrous histiocytomas (FHs are mesenchymal tumors that may be benign or malignant. Ocular involvement by FHs is infrequent and primarily limited to the orbit. Rarely, FHs can also involve the conjunctiva and perilimbal area. We report the case of a 38-year-old male with lid, conjunctival, and neck FHs. The diagnosis was confirmed by histopathology.

  20. An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report

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    Wang Lian-Li

    2013-01-01

    Full Text Available Abstract Introduction Malignant fibrous histiocytoma is a very common subtype of soft-tissue sarcoma in middle and late adulthood. However, malignant fibrous histiocytoma of the testis is very rare in adolescents. Case presentation We report here the case of a 14-year-old Han Chinese boy, who presented with left scrotal mass lasting for 20 days along with distending pain for 5 days. A physical examination revealed a chicken egg-sized, firm, well-defined mass and unclear epididymis. A B-scan ultrasonography of the left scrotum displayed a 9.0脳5.2脳4.5cm medium- or low-echoic lobulated mass, which suggested a left testicular neoplasm. A fine needle aspiration cytology examination revealed that the cells obtained from the patient鈥檚 testicular neoplasm were composed of myxoid spindle, and ovoid cells with nuclear atypia and mitotic activity, and arranged in a whirlpool or storiform pattern. Under histological examination, the tumor cells were arranged in a storiform pattern, which displayed mucoid matrix degeneration, and grew invasively. Consequently, a histopathological diagnosis suggested myxofibrosarcoma (or myxoid malignant fibrous histiocytoma. Conclusions An ultrasonic examination combined with fine needle aspiration cytology should be helpful for the initial differential diagnosis of testicular malignant fibrous histiocytoma. However, the final confirmation relies on histopathological examination. To the best of our knowledge, this is the first reported case of malignant fibrous histiocytoma of the testis in an adolescent.

  1. Primary malignant fibrous histiocytoma of the lung in a pediatric patient

    International Nuclear Information System (INIS)

    The case of a girl with primary malignant fibrous histiocytoma of the lung is presented. The patient presented no previous pathology. Laboratory tests, chest X-ray, chest ultrasound and computed tomography were performed, but the definitive diagnosis was based on biopsy. (Author) 10 refs

  2. Haematoma-like primary intracranial malignant fibrous histiocytoma in a 5-year-old girl

    International Nuclear Information System (INIS)

    We present CT and MRI of an intracranial malignant fibrous histiocytoma in a 5-year-old girl with headache and vomiting. This case is unusual particular by virtue of its radiological appearances and the young age of the patient. (orig.)

  3. Primary malignant fibrous histiocytoma of the sigmoid colon: a case report.

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    Rubbini, M; Marzola, A; Spanedda, R; Scalco, G B; Zamboni, P; Guerrera, C; Donini, I

    1983-01-01

    This paper presents a case of malignant fibrous histiocytoma localized in the sigmoid colon with multiple metastases in the right lobe of the liver and describes the pathological and microscopic aspects, clinical course and characteristics. The primary localization in the sigmoid colon is extremely rare, this being only the second case reported. PMID:6323346

  4. Single somatic ras gene point mutation in soft tissue malignant fibrous histiocytomas.

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    Bohle, R. M.; Brettreich, S.; Repp, R.; Borkhardt, A.; Kosmehl, H.; Altmannsberger, H. M.

    1996-01-01

    The frequency of ras gene mutations in human soft tissue malignant fibrous histiocytomas within and around the hot spot codons (12, 13, and 61) of all ras genes, (H-ras-1, K-ras-2, and N-ras) was studied by nested polymerase chain reaction and direct DNA sequencing from archival formalin-fixed, paraffin-embedded tissue. Light microscopy and immunohistochemistry served to define malignant fibrous histiocytoma. All of the four differentiation subtypes (storiform-pleomorphic, inflammatory, myxoid, and giant cell) were investigated. Nine of thirty-two malignant fibrous histiocytomas (28%) contained ras gene point mutations. The highest incidence was found in the myxoid subtype (four of nine). H-ras-1 gene codon 12.2 was the only codon affected and contained in all mutated cases a GGC-->GTC exchange. Seven of the nine mutations were homozygous and probably affected more than 80% of the tumor DNA. The flanking regions of all hotspot codons did not contain any point mutation. The presence of a single and often homozygous point mutation of the H-ras-1 gene, especially in myxoid malignant fibrous histiocytoma could serve as a basis for further genomic discrimination of myxoid sarcomas. Images Figure 1 PMID:8774129

  5. Fibrosarcoma and malignant fibrous histiocytoma of long bones: Radiographic features and grading

    International Nuclear Information System (INIS)

    The salient radiological features of 102 cases of fibrosarcoma and of so-called malignant fibrous histiocytoma (MFH) of the long bones are presented. All cases registered with the Netherlands Committee on Bone Tumours in the period 1953-1976, were originally classified as fibrosarcoma. In a recent review of the pathological material approximately half of these tumours were reinterpreted as malignant fibrous histiocytoma. As the two neoplasms demonstrate no difference in their clinical picture, radiological appearance, and survival statistics, we did not study both groups separately. Favourable radiographic signs which suggest a longer survival rate included: a geographic type of bone destruction, eccentric location, and cortical destruction involving no more than two quadrants of the bone circumference. Based on these findings a grading system is presented which differs from that proposed by Lodwick et al. (orig.)

  6. Malignant fibrous histiocytoma presenting with complete opacification of the hemithorax: A case report

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    Jean Salem; Ali Shamseddine; Mohamad Khalife; Ghina El Nounou; Abdallah Abou EL Naaj; Deborah Mukherji; Ali Haydar; Walid Faraj

    2014-01-01

    BACKGROUND: Malignant fibrous histiocytoma, a subtype of primary lung sarcoma is a very rare disease. It usually presents as a lung nodules and the final diagnosis is made by immunohistochemical studies. METHODS: A 45-year-old patient presented with progressive dyspnea, dry cough and right shoulder pain. Chest X-ray revealed complete opacification of the right hemithorax. Chest computed tomography confirmed the presence of a heterogeneous lesion occupying the whole right hemithorax causing...

  7. Malignant Fibrous Histiocytoma of the Maxillary Sinus in a Spray Painter from an Automobile Repair Shop

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    Choi, Seok-Hwan; Kim, Se-Yeong; Son, Man-Ki; Yang, Hui-Seok; Lee, Sun-Woo; Kim, Jung-Il; Jung, Kap-Yeol

    2013-01-01

    Background We report a case of a spray painter who developed malignant fibrous histiocytoma (MFH) of the maxillary sinus following long-term exposure to chromium, nickel, and formaldehyde, implying that these agents are probable causal agents of MFH. Case report The patient developed right-sided prosopalgia that began twenty months ago. The symptom persisted despite medical treatment. After two months, he was diagnosed with MFH through imaging studies, surgery, and pathological microscopic fi...

  8. Primary giant cell malignant fibrous histiocytoma-associated with renal calculus

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    Altunkol, Adem; Savas, Murat; Ciftci, Halil; Gulum, Mehmet; Yagmur, Ismail; Bitiren, Muharrem

    2014-01-01

    Malignant fibrous histiocytomas (MFH) are the most commonly seen soft tissue sarcomas in adults. It is rarely seen in some visceral organs. Kidneys are the parenchymal organs in which MFHs are most frequently seen. More than 50 cases of primary renal MFH have been reported. Among these cases, only 1 was reported as primary giant cell subtype in association with urolithiasis. This case report is the second such case with the these characteristics. PMID:24678364

  9. Malignant fibrous histiocytoma following radiation therapy and chemotherapy for Hodgkin's lymphoma

    International Nuclear Information System (INIS)

    Malignant fibrous histiocytoma (MFH) originates from primitive mesenchymal cells and has the capacity for dual differentiation into histiocytes and fibroblasts. MFH occurring as a secondary malignancy following radiochemotherapy is rare and its exact incidence is not yet known. Here we report a case of a 42-year-old man who developed MFH in his right knee over a period of more than 10 years after radio (44 Gy)-chemotherapy to treat Hodgkin's lymphoma. After the diagnosis the patient did not return and was lost to follow-up. This is a rare case with unusual presentation, and it highlights the importance of the awareness and prevention of such secondary tumors. (author)

  10. Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature

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    Yao Dianbo

    2012-01-01

    Full Text Available Abstract Background A malignant fibrous histiocytoma is a soft tissue tumor that most commonly occurs in the extremities, but rarely involves the liver. The clinical characteristics and therapeutic experiences of primary hepatic malignant fibrous histiocytoma are still limited. Methods Two cases of primary hepatic malignant fibrous histiocytoma were analyzed retrospectively, and all the literature concerning primary hepatic malignant fibrous histiocytoma was analyzed. Results In China, a total of 76 cases had been reported, among which 50 were men, with a male to female ratio of 1.9:1. Mean age of the patients was 51.0 years old, and more than 85 percent were older than 40 years. 82.9 percent (63/76 of hepatic MFH were solitary lesions, with tumor size ranging from 2.5 to 23.5 cm (average 10.3 cm. Major clinical presentation (78.4% was abdominal pain or discomfort, accompanied with some other non-specific symptoms such as malaise, anorexia, weight loss, jaundice and fever, and small cases (14.9% were asymptomatic. Computed tomography and ultrasound usually revealed the location of lesions. The rate of pre-operative misdiagnosis was extremely high, and 14.9 percent of patients were even misdiagnosed as a benign liver cyst, liver abscess or hematoma. Integrated resection was performed among the most cases (49/68, among which only a few ones (12 cases were introduced to have no recurrence or metastasis or be still alive with no detail information provided, while among the cases with palliative operation or only a biopsy, the cases that were followed-up all died. Conclusions Hepatic malignant fibrous histiocytoma is a rare malignant mesenchymal tumor. The variable features of clinical presentations and images make the diagnosis difficult. Though the prognosis of primary hepatic malignant fibrous histiocytoma was rather poor, integrated resection might provide a few cases a good opportunity for surviving, suggesting that surgery might be an effective treatment.

  11. Post-radiation malignant fibrous histiocytoma following treatment of breast cancer: A case report

    International Nuclear Information System (INIS)

    Post-radiation malignant fibrous histiocytoma (MFH) of the breast is extremely rare. We report a case of post-radiation MFH that presented a rapidly growing mass in a 52-year-old woman who underwent breast-conserving therapy and adjuvant whole breast irradiation 6 years ago. To the best of our knowledge, only one case of primary MFH of the female breast have been reported with sonographic findings. We analyzed the sonographic and MRI findings with correlative histopathologic features, and then confirmed with surgical excision.

  12. Treatment Option Overview (Osteosarcoma and Malignant Fibrous Histiocytoma of Bone)

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    ... combines the pictures from a positron emission tomography (PET) scan and a computed tomography (CT) scan. The PET ... than either test would make by itself. A PET scan is a procedure to find malignant tumor cells ...

  13. General Information about Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

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    ... combines the pictures from a positron emission tomography (PET) scan and a computed tomography (CT) scan. The PET ... than either test would make by itself. A PET scan is a procedure to find malignant tumor cells ...

  14. Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients

    International Nuclear Information System (INIS)

    Among the 130 primary or secondary malignant fibrous histiocytomas of bone diagnosed and treated at Memorial Hospital for Cancer and Allied Diseases during the previous half century, 20 (15.4%) arose as a direct consequence of irradiation. This type is the commonest secondary osseous malignant fibrous histiocytoma at this institution. It affects the ilium, the scapula, and the distal end of the femur most frequently, predominantly in patients whose age peaks in the fifth decade of life, when their sarcomas developed. Grounds for the irradiation were either nonosseous conditions (13 patients) or preexistent skeletal lesions (seven patients). Reasons for the incidental bone irradiation included Hodgkin's disease; carcinoma of cervix, breast, or lung; bilateral retinoblastoma, and others; giant cell tumors predominated among the irradiated skeletal lesions. The mean and the median radiation doses were 6,040 and 5,700 rads, respectively. The latent period between irradiation and the appearance of the bone sarcoma ranged from 4 to 47 years with a mean of 16.5 and a median of 14.5 years, respectively. The cumulative disease-free survival rate at 3 years was 58%. Although all patients who received their radiation therapy for a preexistent bone lesion survived, only 27% of patients whose bone was normal at the time of irradiation are alive and well at the 3-year mark

  15. Report of a Rare Case of Malignant Fibrous Histiocytoma of Mandible

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    Fatemeh Ahmadi-Motamayel

    Full Text Available Introduction: Malignent Fibrous Histiocytoma (MFH is the most frequent soft tissue sarcoma of adulthood. The most common sites affected by MFH are limbs, orbit, retroperitoneum, pelvis and knee. Oral cavity and mandible involvements are very rare. Case Report: A 35-year-old male was visited in the oral medicine department of Hamadan dental school with the chief complaint of pain and teeth mobility. The patient also had a history of paresthesia in lower lip for two monthes. In intraoral examination, there was a crater like, deep and disseminated ulcer in lower buccal and ligual gingiva of right mandibular teeth and exophitic lesion with smooth surface, and color similar to normal mucosa with 2󫎿 cm in diameter in buccal and lingual part of right lateral and central teeth extended to left second premolar was observed. Gingival resorption was observed in all adjascent teeth. There was radiolucency with irregular border in all part of lesion. MFH was confirmed by histopathological report.Conclusion: The most common complaint of patients with malignant fibrous histiocytoma is the growing mass that could be ulcerative or painful. Early diagnosis and referral is very important in prognosis and survival of the patients.

  16. Malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma of the penis. A case report

    International Nuclear Information System (INIS)

    We report the case of a malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (MFH/UPS) of the penis in a 78-years-old-man who had undergone previous radical prostatectomy, external beam radiation therapy for prostatic adenocarcinoma. The mass was a 9-cm firm lesion at the base of the penis predominantly composed of malignant spindle cells arranged in sweeping fascicles and storiform pattern. The tumor cells stained for vimentin, 伪-smooth muscle actin, S-100, and were negative for keratin, desmin, Melan A, prostate specific antigen (PSA). Despite total penectomy, he developed a local reccurence 4 months after surgery, and died from dissemination 6 months after surgery. This is the 8th case of penile MFH/UPS. (author)

  17. A rare case report of malignant fibrous histiocytoma of male breast

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    Rajshri P Damle

    2016-01-01

    Full Text Available Malignant fibrous histiocytoma (MFH is an extremely rare tumor of the breast that arises from the connective tissue of glands. Its complex and various histological patterns, adds difficulty to the diagnosis. We report a case of MFH of left breast in a 70-year-old male who presented with gradually increasing painless mass over a period of 1鈥2 years. Fine-needle aspiration cytology revealed malignant spindle cell lesion and wide local excision was performed without axillary lymph node dissection. Histopathological examination along with immunohistochemistry confirmed the diagnosis of MFH of left breast. To the best of our knowledge, this is the 6th case of MFH of left breast in an elderly male reported in the literature.

  18. Primary malignant fibrous histiocytoma in mediastinum: Imaging with 18F FDG PET/CT

    International Nuclear Information System (INIS)

    Malignant fibrous histiocytoma (MFH) is the most common soft tumor which often occurs in the extremities and the retroperitoneum. Pimary mediastinal MFH is rare; thus, findings on 18F fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG PET/CT) of mediastinal MFH have not been reported yet. We report herein the case of a 64 year old man who was presented with a superior mediastinal mass. the mass showed intense 18F FDG uptake with central metabolic defect on PET/CT the maximum standardized uptake value was 17.4. after tumor removal via median sternotomy, an MFH of the storiform pleomorphic type was diagnosed on histopathologic examination. We the first report of 18F FDG PET/CT imaging of MFH in the superior mediastinum

  19. Malignant fibrous histiocytoma of the urinary bladder as a post-radiation secondary cancer: a case report

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    Nimmanon Thirayost

    2011-11-01

    Full Text Available Abstract Introduction Malignant fibrous histiocytomas have been periodically reported as the primary tumor in various organs including the urinary bladder, and is the second most frequent sarcoma of the urinary tract in adults. This report discusses a case of the well established diagnosis of a malignant fibrous histiocytoma of the bladder occurring as a post-radiation cancer after the treatment of a cervical carcinoma. Our findings support those of many previous studies and make the view of the nature of the disease clearer. Case presentation We report the case of a 54-year-old Thai woman who had been treated with radiation therapy for cervical cancer, who presented to our facility with urinary incontinence. Initially, our patient was diagnosed as having a high-grade urothelial carcinoma. Subsequent radical surgery rendered the final pathological diagnosis, confirmed histologically and immunohistochemically as malignant fibrous histiocytoma, with clinical and pathological staging of T4b N0 M0. Adjuvant chemotherapy was provided for our patient. Conclusions This type of malignancy is very aggressive and easily misdiagnosed due to its rarity. Therefore, in a patient with a prior history of irradiation in the pelvic area, this should be considered as a differential diagnosis to ensure early correct diagnosis and treatment.

  20. CyberKnife radiotherapy for malignant fibrous histiocytoma of the chest wall: A case report and review of the literature

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    Wang, Zhen; WU, XIN-HU; Li, Bing; Kong, Qing-Tao; Shen, Ze-Tian; Li, Jing; LIU, ZHI-BING; Zhu, Xi-Xu

    2014-01-01

    Malignant fibrous histiocytoma (MFH) is the most common type of soft tissue sarcoma, but rarely originates in the chest wall. Surgical resection is considered to be the most reliable treatment, however, no consensus has been reached concerning the best treatment for unresectable MFH. The current study presents the case of a 77-year-old male with MFH of the chest wall. The patient developed a painless mass and intermittent fever over a four-month period. A computed tomography scan demonstrated...

  1. Manifestations and therapy of malignant fibrous histiocytomas in the head and neck area

    International Nuclear Information System (INIS)

    From 1982 through 1987, ten patients with malignant fibrous histiocytomas (MFH) in the head and neck area were treated at the ORL Department of the Central Hospital of Bremen. The primary tumor was situated in the region of the paranasal sinuses in six cases and in the parotid gland, the thyroid gland, the inferior maxilla, and the petrosal bone in one case, each. Nine patients were submitted to primary surgery. A postoperative irradiation was performed in four cases, and in four further cases this was done only when a recurrent tumor had been demonstrated. Three patients received a combined chemotherapeutical treatment. Eight patients died, the median survival time was 15 months. Besides local recurrences which occured frequently, remote metastases are the decisive factor for the further evolution of the disease. The lung was the most common site of metastatic spread. Only two patients with MFH of the parasanal sinuses are living now without recurrence after an observation time of 24 and 36 months, respectively. (orig.)

  2. Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report

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    Park, Hye Young; Seo, Jung Wook; Lee, Byung Hoon; Lee, Ji Young; Kim, Su Young; Cha, Soon Joo; Kim, Yong Hoon; Hwang, Yoon Joon; Kim, You Sung [Dept. of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang (Korea, Republic of)

    2013-03-15

    A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

  3. Malignant fibrous histiocytoma of the deep peri-articular tissue of the stifle in a dog : case report

    Directory of Open Access Journals (Sweden)

    M.J. Booth

    1998-07-01

    Full Text Available A Belgian shepherd dog aged 4 years and 9 months was presented with acute onset of non-weight bearing lameness and stifle effusion of the left hind limb, caused by the deep form of a malignant fibrous histiocytoma originating in the deep musculature and fascia surrounding the stifle joint. The tumour progressed rapidly in the tissues along the femoral diaphysis with marked periosteal new bone formation. Cytology of a stifle joint aspirate revealed numerous large polygonal neoplastic cells with considerable anisocytosis and anisokaryosis. These cells were present in clusters, with cytoplasmic projections between the cells, but occasionally also occurred singly. Several cells contained multiple cytoplasmic vacuoles and occasional giant cells were also encountered. Adequate tumour-free margins were not possible with radical limb amputation and the dog was euthanased. Macroscopically the tumour appeared as an extensive pale tan, firm mass with scattered small haemorrhages and foci of yellow discolouration. Histologically the tumour consisted of dense neoplastic expanses or multiple nodules, composed of spindle-shaped fibroblastic cells, polygonal histiocytic cells or cell clusters and scattered giant cells with 2-3 nuclei. The polygonal neoplastic cells were frequently present around and invading lymphatics and blood vessels, causing neoplastic emboli. This is the 1st report of the clinical behaviour, radiography and cytology of the deep form of malignant fibrous histiocytoma in the dog.

  4. Metastatic Malignant Fibrous Histiocytoma Infiltrating Sigmoid Colon: A Case Diagnosed With the Help of 18F-FDG PET/CT.

    Science.gov (United States)

    Wei, Wei-Jun; Shen, Chen-Tian; Song, Hong-Jun; Qiu, Zhong-Ling; Luo, Quan-Yong

    2016-04-01

    Metastatic malignant fibrous histiocytoma (MFH) in the colon is extremely rare, although MFH is one of the most common soft tissue sarcomas in adults. We report the case of a 45-year-old woman with metastatic MFH in the sigmoid colon, descending colon, and right lung with FDG PET/CT findings. PMID:26673233

  5. Malignant fibrous histiocytoma of the distal femur after an arthroscopic anterior cruciate ligament reconstruction: A case report and a review of the literature

    International Nuclear Information System (INIS)

    Malignant degeneration in association with orthopaedic implants is a known but rare complication. To our knowledge, no case of osseous malignant fibrous histiocytoma after anterior cruciate ligament reconstruction is reported in the literature. We report a 29-year-old male Turkish patient who presented with severe pain in the operated knee joint 40 months after arthroscopic anterior cruciate ligament reconstruction. X-ray and MR imaging showed a large destructive tumor in the medial femoral condyle. Biopsy determined a malignant fibrous histiocytoma. After neoadjuvant chemotherapy, wide tumor resection and distal femur reconstruction with a silver-coated non-cemented tumor knee joint prosthesis was performed. Adjuvant chemotherapy was continued according to the EURAMOS 1 protocol. Though secondary malignant degeneration after orthopaedic implants or prostheses is not very likely, the attending physician should take this into consideration, especially if symptoms worsen severely over a short period of time

  6. Accumulation of MRI contrast agents in malignant fibrous histiocytoma for gadolinium neutron capture therapy

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, T. [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan)], E-mail: fujitaku@hp.pref.hyogo.jp; Ichikawa, H. [Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586 (Japan); Akisue, T. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Fujita, I. [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan); Kishimoto, K.; Hara, H. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Imabori, M. [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan); Kawamitsu, H. [Department of Radiology, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Sharma, P.; Brown, S.C.; Moudgil, B.M. [Particle Engineering Research Center, University of Florida, Gainesville, FL32611 (United States); Fujii, M. [Department of Radiology, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Yamamoto, T. [Department of Orthopaedic Surgery, Kagawa University, Kagawa 761-0793 (Japan); Kurosaka, M. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Fukumori, Y. [Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586 (Japan)

    2009-07-15

    Neutron-capture therapy with gadolinium (Gd-NCT) has therapeutic potential, especially that gadolinium is generally used as a contrast medium in magnetic resonance imaging (MRI). The accumulation of gadolinium in a human sarcoma cell line, malignant fibrosis histiocytoma (MFH) Nara-H, was visualized by the MRI system. The commercially available MRI contrast medium Gd-DTPA (Magnevist, dimeglumine gadopentetate aqueous solution) and the biodegradable and highly gadopentetic acid (Gd-DTPA)-loaded chitosan nanoparticles (Gd-nanoCPs) were prepared as MRI contrast agents. The MFH cells were cultured and collected into three falcon tubes that were set into the 3-tesra MRI system to acquire signal intensities from each pellet by the spin echo method, and the longitudinal relaxation time (T1) was calculated. The amount of Gd in the sample was measured by inductively coupled plasma atomic emission spectrography (ICP-AES). The accumulation of gadolinium in cells treated with Gd-nanoCPs was larger than that in cells treated with Gd-DTPA. In contrast, and compared with the control, Gd-DTPA was more effective than Gd-nanoCPs in reducing T1, suggesting that the larger accumulation exerted the adverse effect of lowering the enhancement of MRI. Further studies are warranted to gain insight into the therapeutic potential of Gd-NCT.

  7. Oral benign fibrous histiocytoma: two case reports

    OpenAIRE

    Menditti, Dardo; Laino, Luigi; Mezzogiorno, Antonio; Sava, Sara; Bianchi, Alexander; Caruso, Giovanni; Di Maio, Luigi; Baldi, Alfonso

    2009-01-01

    Fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body. The involvement of the oral cavity is rare. We report two cases of benign fibrous histiocytoma that localized in the oral cavity. The clinical and histological features of the lesion are reported. Finally, a literature revision of this pathology at the level of the oral cavity is reported.

  8. 99Tcm-MDP whole body bone scan for the ancillary diagnosis of malignant fibrous histiocytoma of bone

    International Nuclear Information System (INIS)

    Objective: To investigate the usefulness of 99Tcm-MDP whole body bone scan in bone malignant fibrous histiocytoma (BMFH). Methods: Fifteen patients (11 males, 4 females, age ranged from 23 to 60 years,average age (50.4卤12.8) years) who had documented BMFH and underwent 99Tcm-MDP whole body bone scan were retrospectively analyzed. The appearance of increased uptake, decreased uptake or defect in radioactivity on bone was considered as positive. The typical scintigraphic manifestations of BMFH were summarized and compared to other radiological imaging data. Results: All 15 patients showed positive results. The lesions involved femoral in 10 cases(66.7%),46.7%(7/15) of which was distal femur. The lesions also involved sacrum, tibia, humerus, radius each in 1 case and multiple lesions in 1 case. Among 27 lesions found, 63.0% (17/27) showed strong increased radioactivity together with reduced or defect area and 37.0% (10/27) showed strong increased radioactivity only. X-ray found 20 lesions. Twelve cases underwent CT and 7 cases underwent MRI. Abnormal spots showed on CT and MRI were also positive on the whole body bone scan. Conclusions: The most common site of BMFH is femur, especially distal femur. BMFH lesions are presented as strong increased radioactivity together with sparse and defect area on bone scan. The whole body bone scan may be an auxiliary examination to evaluate whether there are multiple bone lesions and bone metastasis. (authors)

  9. Calculation of probability of causation for non-specified radiogenic cancer cases. Etiologic judgement of a malignant fibrous histiocytoma developed at the elbow of a plutonium contaminated worker

    International Nuclear Information System (INIS)

    A criterion for the compensation of patients with radiogenic cancer has been formulated for five specified cancers. A method of calculation of the probability of causation (PC) of non-specified cancers was applied to a case of malignant fibrous histiocytoma developed at the elbow of a plutonium contaminated worker. According to the histologic structure of the tumour, there were three possible target cells, and their doses were evaluated with the available data of urine plutonium. Then PC was calculated with excess relative risk coefficient indirectly deduced from related animal experiment. The result showed that the obtained PC varied greatly with the supposed target cells. If the target cells were periosteum cells, the PC might exceed 50 percent, but that might not be true, and the tumour might come from fibroblasts, and then PC might be less than 1 percent

  10. A case of radiation-induced sternal malignant fibrous histiocytoma treated with neoadjuvant chemotherapy and surgical resection

    OpenAIRE

    Erekul Selim; Budakoglu Burcin; Erdogan Bulent; Gulbahar Gultekin; Kocer Bulent; Dural Koray; Sakinci Unal

    2008-01-01

    Abstract Background Primary sternal malignant fibrous histiyocytoma (MFH) is highly rare. Effective treatment modality is surgical resection with wide margins. However, to date, the effects of radiotherapy or chemotherapy has not been clearly defined. Case presentation Herein, we aimed to present a 50-year old female patient with MFH occurred in the radiotherapy field who had had surgical procedure for breast cancer 19 years ago and had followed by radiotherapy. Neoadjuvant chemotherapy was a...

  11. Benign Fibrous Histiocytoma: A Rare Case Report and Literature Review.

    Science.gov (United States)

    Prasanna Kumar, D; Umesh; Rathi, Tushar; Jain, Vaibhav

    2016-03-01

    Fibrous histiocytoma is a benign soft tissue tumour that may present as a fibrous mass anywhere in the human body. The involvement of the oral cavity is extremely rare and very few cases have been reported in literature till date. We here report a case of benign fibrous histiocytoma localized in the oral cavity. The clinical and histological features of the lesion are discussed precisely in the light of a literature review of this pathology in oral cavity. PMID:26929563

  12. Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization

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    Isayama Teruto

    2010-11-01

    Full Text Available Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluorescence in situ hybridization (M-FISH, Urovysion鈩 FISH, and comparative genomic hybridization (CGH for the characterization of chromosomal aberrations. FU-MFH-2 cells were spindle or polygonal in shape with oval nuclei, and were successfully maintained in vitro for over 80 passages. The histological features of heterotransplanted tumors in severe combined immunodeficiency mice were essentially the same as those of the original tumor. Cytogenetic and M-FISH analyses displayed a hypotriploid karyotype with numerous structural aberrations. Urovysion鈩 FISH revealed a homozygous deletion of the p16INK4A locus on chromosome band 9p21. CGH analysis showed a high-level amplification of 9q31-q34, gains of 1p12-p34.3, 2p21, 2q11.2-q21, 3p, 4p, 6q22-qter, 8p11.2, 8q11.2-q21.1, 9q21-qter, 11q13, 12q24, 15q21-qter, 16p13, 17, 20, and X, and losses of 1q43-qter, 4q32-qter, 5q14-q23, 7q32-qter, 8p21-pter, 8q23, 9p21-pter, 10p11.2-p13, and 10q11.2-q22. Conclusion The FU-MFH-2 cell line will be a particularly useful model for studying molecular pathogenesis of human pleomorphic MFH.

  13. Case report 359: Gigantic benign fibrous histiocytoma (nonossifying fibroma)

    International Nuclear Information System (INIS)

    In summary, a fascinating case is presented of an enormous 'blow-out' lesion in the left half of the mandible in a 17-year-old boy. The histological diagnosis was benign fibrous histiocytoma or non-ossifying fibroma. An extensive differential diagnosis was presented by the authors and although benign fibrous histiocytoma was their final diagnosis, they could not exclude an example of the rarely encountered entity called the Jaffe-Campanacci syndrome. This syndrome consists of multiple non-ossifying fibromas of the mandible, cafe-au-lait spots, various endocrine disorders, mental retardation, occular anomalies and cardiovascular malformations. (orig./SHA)

  14. Pleomorphic malignant histiocytoma: a rare skin cancer in a patient on azathioprine for ulcerative colitis

    Science.gov (United States)

    Sood, Ruchi; Daw, Hamed A

    2012-01-01

    A 67-year-old female who was diagnosed with ulcerative colitis in 2001, presented with a soft tissue mass in the middle of her back of 4 months duration in April 2011. It was excised; however it recurred at the same site in September 2011. Wide excision of the mass was done. Pathology revealed T1aNxM0 pleomorphic malignant fibrous histiocytoma or undifferentiated pleomorphic sarcoma. Whole body bones scan and staging CT scan of the chest, abdomen and pelvis was negative for distant metastasis. She received local radiotherapy at the site of excision. No chemotherapy was given. PMID:22761209

  15. Benign Fibrous Histiocytomas of the Oral Mucosa: Report on Three Cases and Review of the Literature

    Science.gov (United States)

    Prisse, Laure-Anne; Jayasooriya, Primali Rukmal; Mendis, Balapuwaduge Ranjit Rigorbert Nihal; Lombardi, Tommaso

    2015-01-01

    Benign fibrous histiocytomas (BFH) of the skin are common lesions, although they only rarely involve the oral mucosa. This article presents 3 additional cases of BFH of the oral mucosa, with a review of previously published cases. Although a malignant variant of BFH also exists, the present review focuses only on benign lesions. The clinical presentation, diagnosis, histopathological and immunohistochemical features of BFH are discussed. According to the present analysis, the majority of oral mucosal BFH have occurred in middle-aged and elderly patients, with a slight female predilection. Within the oral cavity, BHF may occur at any mucosal site, including the lips, tongue, buccal mucosa, mandibular and maxillary gingiva as well as the palate. Histopathology is essential to diagnose the lesion, while immunohistochemical investigations may be utilized to exclude the histopathological differential diagnoses such as juvenile xanthogranulomas and nevi. This review also revealed total excision as the treatment of choice for BFH, with a very good prognosis and an extremely low rate of relapse.

  16. Radiation induced malignant histiocytoma of the contralateral breast following treatment of breast cancer: a case report and review of the literature

    OpenAIRE

    Biswas, Saptarshi; Badiuddin, Faruq

    2008-01-01

    Radiation therapy (XRT) is an important modality for treatment of breast cancer. Its use has occasionally resulted in the development of secondary malignancies. We describe this interesting case of a 46-year-old woman who developed malignant fibrous histiocytoma in the contralateral breast 6 years after a lumpectomy followed by radiation therapy for infiltrating ductal carcinoma. The role of XRT in the treatment of breast carcinoma and development of Radiation induced Sarcoma (RIS) is examine...

  17. Deep benign fibrous histiocytoma in the oral cavity: a case report

    Science.gov (United States)

    Jo, Eun; Cho, Eunae Sandra; Kim, Hyun Sil

    2015-01-01

    Benign fibrous histiocytoma (FH) is a benign tumor composed of fibroblasts and histiocytes in varying proportions. This tumor is usually found in adult extremities but rarely occurs in deep soft tissues of the oral cavity. As it is difficult to diagnose with physical and radiologic exams, deep benign FH can only be diagnosed by histopathology. We report a case of a 36-year-old female patient who came to our department with painless swelling in the right buccal mucosa. This case report reviews the clinical, radiological, and histological aspects of this tumor. PMID:26568930

  18. Fibrohistiocitoma benigno 贸sseo na coluna lombar Benign fibrous histiocytoma of the lumbar spine

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    Osmar Avanzi

    2005-01-01

    Full Text Available CONTEXTO: O fibrohistiocitoma benigno intra-贸sseo 茅 uma neoplasia rara, caracterizada por prolifera莽茫o fibrobl谩stica e fibras col谩genas. A dor na regi茫o lombar 茅 uma queixa freq眉ente em muitos pacientes, mas, na maioria das vezes est谩 relacionada com causa muscular ou degenerativa. RELATO DE CASO: Relata-se aqui o caso de um paciente com diagn贸stico de fibrohistiocitoma benigno 贸sseo na coluna lombar que apresentava queixa de lombalgia h谩 cinco meses antes do diagn贸stico. Foi submetida 脿 bi贸psia aberta transpedicular na quarta v茅rtebra lombar ,e, posteriormente realizada curetagem da les茫o via anterior retroperitonial e artrodese vertebral de L3-L5 com enxerto de f铆bula. CONCLUS脙O: Apesar de raro, o fibrohistiocitoma benigno intra-贸sseo deve ser uma das hip贸teses quando observamos uma les茫o prim谩ria na coluna vertebral.CONTEXT: Benign intraosseous fibrous histiocytoma is a rare neoplasia, characterized by fibroblastic and collagenous fiber proliferation. Pain in the lumbar region is a frequent complaint in many patients, but most of times it is associated to muscular or degenerative causes. CASE REPORT: Here we report a case of a patient diagnosed with benign bone fibrous histiocytoma in the lumbar spine who complained of lumbar pain dating five months prior to diagnosis. The patient was submitted to open transpedicular biopsy in the forth lumbar vertebra, and subsequently, lesion curettage was performed via anterior retroperitoneal and L3-L5 vertebral arthrodesis using a fibular graft. CONCLUSION: Although rare, benign intraosseous fibrohistiocytoma should be taken into consideration when a primary lesion is observed in the spine.

  19. Stages of Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

    Science.gov (United States)

    ... The patient may be fitted with a prosthesis (artificial limb) after amputation. Rotationplasty : Surgery to remove the tumor ... is then attached to the part of the leg that remains above the knee, with the ... as a knee. A prosthesis may then be attached to the foot. Studies ...

  20. Treatment Options for Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

    Science.gov (United States)

    ... The patient may be fitted with a prosthesis (artificial limb) after amputation. Rotationplasty : Surgery to remove the tumor ... is then attached to the part of the leg that remains above the knee, with the ... as a knee. A prosthesis may then be attached to the foot. Studies ...

  1. Malignant transformation of fibrous dysplasia into chondroblastic osteosarcoma

    International Nuclear Information System (INIS)

    A case of malignant transformation of polyostotic fibrous dysplasia into maxillary chondroblastic osteosarcoma is presented. The clinical, radiographic, CT, MR imaging features and pathological findings of polyostotic fibrous dysplasia and its malignant transformation are described. Malignant transformation of fibrous dysplasia is rare and has not previously been described in the English literature in this location in McCune-Albright syndrome and in the absence of radiation treatment. (orig.)

  2. "Malignant" mitral stenosis

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    Auer Johann

    2012-03-01

    Full Text Available Abstract Symptomatic mitral stenosis caused by a left atrial mass as the first sign of metastasis of a malignant tumor is extremely rare and frequently associated with poor prognosis. We report a case of a 59-year-old man with a history of grade 3 malignant fibrous histiocytoma on his left tigh treated by limb-sparing surgery 17 months earlier, who was admitted with 10-days of worsening dyspnea. Imaging revealed a left atrial mass protruding through the mitral valve that resulted in severe mitral stenosis. Biopsy confirmed metastasis of malignant fibrous histiocytoma.

  3. Malignant solitary fibrous tumor in anterior mediastinum with pleural metastasis simulating invasive thymoma

    International Nuclear Information System (INIS)

    Malignant solitary fibrous tumor, which arises in the anterior mediastinum, is rare. Its image findings simulate other mediastinal mass, such as malignant lymphoma, malignant thymic epithelial tumor or invasive thymoma. Here, we report a pleural malignant fibrous tumor of a 60 year old man who is presented with a well defined lobulating anterior mediastinal mass with pleural metastasis mimicking invasive thymoma with pleural seeding

  4. Malignant fibrous histiocytoma presenting with complete opacification of the hemithorax: A case report

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    Jean Salem

    2014-01-01

    CONCLUSION: Progressive dyspnea in young otherwise healthy patients should be investigated early on. In our case the presence of right shoulder pain indicates advance disease illustrated by the singular imaging findings.

  5. Myxoid Type of Malignant Fibrous Histiocytoma of the Maxillary Sinus: A Case Report

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    Amir Hossein Jafarian

    2011-04-01

    Amplified radical surgery is the first choice of treatment. The second surgery has special value to the recurrent patients. Radiotherapy alone or chemotherapy alone is not effective to MFH of head and neck region

  6. Bone Scintigraphy in a Patient With Giant Malignant Solitary Fibrous Tumor of the Pleura.

    Science.gov (United States)

    Zhao, Long; Liu, JinJun; Li, Qiang; Wang, Huo-Qiang

    2016-06-01

    Chest radiograph performed in a 61-year-old woman to evaluate cough showed a large mass in the right lung. On chest CT images, the mass was measured approximately 8.5 cm. Malignancy was considered, and bone scintigraphy was performed to assess possible osseous metastases. The bone scan images demonstrated increased tracer uptake by the lung mass. The mass was surgically resected, and the pathologic examination confirmed the rare diagnosis of a malignancy solitary fibrous tumors of the pleura. PMID:26914570

  7. Unusual malignant solid neoplasms of the kidney: Cross-sectional imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Karaosmanoglu, Ali Devrim; Hahn, Peter F. [Dept. of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston (United States); Shirkhoda, Ali [Dept. of Radiology, University of California School of Medicine, Irvine (United States); Onur, Mehmet Ruhi; Ozmen, Mustafa [Dept. of Radiology, University of Hacettepe School of Medicine, Ankara (Turkmenistan)

    2015-08-15

    Malignant kidney neoplasms are the most frequently encountered solid kidney masses. Although renal cell carcinoma is the major renal malignancy, other solid malignant renal masses should be considered in the differential diagnosis of solid renal masses that do not contain a macroscopic fatty component. In this pictorial essay, we present the imaging findings of a primitive neuroectodermal tumor, primary liposarcoma of the kidney, primary neuroendocrine tumor, leiomyosarcoma, synovial sarcoma, malignant fibrous histiocytoma, sclerosing fibrosarcoma and renal metastasis of osteosarcoma.

  8. Unusual malignant solid neoplasms of the kidney: Cross-sectional imaging findings

    International Nuclear Information System (INIS)

    Malignant kidney neoplasms are the most frequently encountered solid kidney masses. Although renal cell carcinoma is the major renal malignancy, other solid malignant renal masses should be considered in the differential diagnosis of solid renal masses that do not contain a macroscopic fatty component. In this pictorial essay, we present the imaging findings of a primitive neuroectodermal tumor, primary liposarcoma of the kidney, primary neuroendocrine tumor, leiomyosarcoma, synovial sarcoma, malignant fibrous histiocytoma, sclerosing fibrosarcoma and renal metastasis of osteosarcoma

  9. Unusual Malignant Solid Neoplasms of the Kidney: Cross-Sectional Imaging Findings

    Science.gov (United States)

    Karaosmano?lu, Ali Devrim; Shirkhoda, Ali; Ozmen, Mustafa; Hahn, Peter F.

    2015-01-01

    Malignant kidney neoplasms are the most frequently encountered solid kidney masses. Although renal cell carcinoma is the major renal malignancy, other solid malignant renal masses should be considered in the differential diagnosis of solid renal masses that do not contain a macroscopic fatty component. In this pictorial essay, we present the imaging findings of a primitive neuroectodermal tumor, primary liposarcoma of the kidney, primary neuroendocrine tumor, leiomyosarcoma, synovial sarcoma, malignant fibrous histiocytoma, sclerosing fibrosarcoma and renal metastasis of osteosarcoma. PMID:26175585

  10. Primary malignant bone tumors: diagnosis, radiological appearance and therapy

    International Nuclear Information System (INIS)

    Diagnosis, concepts of therapy and prognosis of primary malignant bone tumors require intensive cooperation between orthopedic surgeons, radiologists and pathologists with special knowledge in oncology. The present paper demonstrates relevant topics of diagnosis, radiological appearance and therapy of the osteosarcoma, Ewing's sarcoma, chondrosarcoma and malignant fibrous histiocytoma based on the material of the Vienna Bone Tumor Registry and more than 35 years of cooperation between the Institute of Pathology and Anatomy and the Department of Orthopedics at the University of Vienna. (orig.)

  11. Malignant mesenchymatous tumor of the abdominal cavity

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    K.S. Atmatzidis, T.E. Pavlidis, I.N. Galanis, B.T. Papaziogas, T.B. Papaziogas

    2007-03-01

    Full Text Available SUMMARY Malignant fibrous histiocytoma (MFH represents a soft tissue sarcoma originating from fibroblast cells, and is characterized by a high rate of metastasis or recurrence. The development of this tumor in the gastrointestinal tract is a very rare entity. No more than 30 cases are described in the litrature. We report on a case of such tumor of the abdominal cavity in a 45 year-old woman, presented with epigastric pain, anorexia and weight loss. The CT-scanning revealed the presence of multiple solid tumors in the peritoneal cavity. On the exploratory laparotomy at least 15 solid whitish tumors were found, attached to the wall of the small intestine, as well as to the parietal peritoneum. In addition, there were three metastases revealed in the liver. All tumors were excised; most of them were about 10 cm in diameter. The histopathologic study indicated the presence of a stromal tumor consisting of spindle cells. The consequent immuno- histo-chemical examination of the resected specimens established the definite diagnosis of a pleomorphic malignant fibrous histiocytoma. The postoperative course of the patient was uneventful. She received adjuvant chemotherapy and is still alive and in good health two years later. Key words: malignant fibrous histiocytoma, soft tissue tumors, stromal tumors, sarcomas, storiform-pleomorphic lesions.

  12. Two malignant solitary fibrous tumors in one kidney: Case report and review of the literature

    OpenAIRE

    ZHAO, GUANGNING; Li, Gang; HAN, RUIFA

    2012-01-01

    Malignant solitary fibrous tumors of the kidney are very rare. Two tumors in one kidney is particularly rare and has not been previously reported. Due to the non-specific clinical symptoms, it is difficult but also very significant to give a definite diagnosis. Here, we report a case of two renal masses in one kidney. A 56-year-old man was admitted to our hospital complaining of shortness of breath, weakness, hyperhidrosis and intermittent hypoglycemia of 1-year duration without gross hematur...

  13. Malignant solitary fibrous tumor of the thigh in a young female: A rare case report

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    Rajeev Sen

    2015-01-01

    Full Text Available Solitary fibrous tumor (SFT is a mesenchymal origin tumor mainly confined to pleura and peritoneum. The extrapulmonary location is rare in incidence up to the level that fewer than 40 cases are described in literature in soft parts of extremities most of which are benign in nature with a mean age of presentation 52 years. The extrapulmonary SFT with malignant features at young age is an extremely rare mesenchymal neoplasm. A 20 years old female presented with a mass in the left thigh. The positron emission tomography scan performed, showed a hypermetabolic lesion at medial side of the left thigh. Subsequently, en bloc excision of mass was done along with adductor longus and brevis. Based on the histomorphology and immunohistochemical markers, diagnosis of malignant SFT was made. We report this case because of its rarity and to add on to literature and list of differential diagnosis of soft tissue tumors in the extremities.

  14. Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature

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    Wellington Alves Filho

    2014-06-01

    Full Text Available Solitary fibrous tumor (SFT is an uncommon spindle-cell neoplasm that most often involves the pleura, rarely occurring in extra-thoracic locations. Twenty-six cases of SFT arising in the thyroid gland have been described. We report a case of a 60-year-old woman presenting an 8-month history of enlargement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisable.

  15. Tumor fibroso solit醨io maligno de extremidades Malignant solitary fibrous tumour of the extremities

    Directory of Open Access Journals (Sweden)

    Daniel Chang

    2010-01-01

    Full Text Available Tumor fibroso solit醨io extrapleural (TFS neoplasia mesenquimal rara, sendo que h menos de 40 casos descritos com localiza玢o em extremidades at o presente momento. Acomete preferencialmente pacientes na quinta d閏ada e n鉶 tem predile玢o por sexo. Relatamos um caso com os aspectos cl韓icos, radiol骻icos, histol骻icos e imunoistoqu韒icos caracter韘ticos, discutindo a import鈔cia do diagn髎tico diferencial com outros sarcomas.Pouco conhecido sobre o comportamento biol骻ico do TFS. Fatores de risco para menor sobrevida livre de met醩tases incluem: margens cir鷕gicas comprometidas, tamanho maior que 10 cm e histologia maligna. Excis鉶 completa o tratamento recomendado.Extrapleural solitary fibrous tumour (SFT is a rare mesenchymal neoplasm, with less than 40 cases reported affecting the extremities so far. This tumour affects preferentially middle-aged patients (median: 50 years and shows no predilection for sex. We report a case with typical clinical, radiologic, histopathologic and immunohistochemical features, discussing the importance of differential diagnosis of other sarcomas. Little is known about the biological behavior of SFT. Risk factors for shorter metastasis-free survival include impaired surgical margins, tumor size greater than 10 cm and malignant histology. Complete excision is the recommended treatment.

  16. CT findings in malignant pleural mesothelioma related to nonoccupational exposure to asbestos and fibrous zeolite (erionite)

    International Nuclear Information System (INIS)

    Endemic malignant pleural mesothelioma (MPM) in Turkey is related to two mineral fibers, tremolite asbestos and fibrous zeolite (erionite). Thirteen cases of MPM from the Cappadocian area, where the soil is rich in erionite, and 29 cases of MPM, from villages whose occupants have high asbestos exposure, were examined by CT. The CT findings of the two groups of MPM were compared with respect to the configuration of the pleural lesions, stage of disease, fissural involvement, pleural effusion, presence of calcified pleural plaques, and chronic fibrosing pleuritis. In erionite-related MPM the pleural lesions were flat and smooth in 69.1%; in asbestos-related MPM the lesions were nodular in 55.1%. Stage IV disease, calcified pleural plaques, and chronic fibrosing pleuritis were more common in the erionite-related MPM. The rest of the findings were similar in both groups. The early radiological diagnosis of erionite-related MPM may be even more difficult because of the similarity of the pleural lesions to chronic fibrosing pleuritis

  17. Renal malignant solitary fibrous tumor with single lymph node involvement: report of unusual metastasis and review of the literature

    Directory of Open Access Journals (Sweden)

    Mearini E

    2014-05-01

    Full Text Available Ettore Mearini,1 Giovanni Cochetti,1 Francesco Barillaro,1 Sonia Fatigoni,2 Fausto Roila2 1Department of Medical-Surgical Specialties and Public Health, Division of Urological Andrological Surgery and Minimally Invasive Techniques, University of Perugia, Terni, Italy; 2Medical Oncology, S Maria Hospital, Terni, Italy Abstract: Solitary fibrous tumors are rare mesenchymal spindle cell neoplasms that are usually found in the pleura. The kidneys are an uncommon site and only few cases of renal solitary fibrous tumor exhibit malignant behavior metastasizing to the liver, lung, and bone through the hematogenous pathway. Purpose: To describe the first case of lymph node metastasis from renal solitary fibrous tumor in order to increase the knowledge about the malignant behavior of these tumors. Patients and methods: A 19-year-old female patient had intermittent hematuria for several months without flank pain or other symptoms. A chest and abdomen CT scan was performed and showed a multi-lobed bulky solid mass of 170 脳 98 脳 120 mm in the left kidney. One day before the surgery, the left renal artery was catheterized and the kidney embolization was performed using a Haemostatic Absorbable Gelatin Sponge and polyvinyl alcohol. We then performed a radical nephrectomy with hilar, para-aortic, and inter-aortocaval lymphadenectomy. Results: Estimated intraoperative blood loss was 200 mL and the operative time was 100 minutes. No postoperative complications occurred. The hospital stay was 7 days long. The histological examination was malignant solitary fibrous tumor of the kidney. Cancerous tissue showed cellular atypia, with an increased mitotic index (up to 7 脳 10 hpf. Immunohistochemical analysis showed positive results for CD34, BCL2, partial expression of HBME1, and occasionally of synaptophysin. Histological evaluation confirmed the presence of metastasis in one hilar node. The patient did not receive any other therapy. At 30-month follow-up, the patient was in good health and no local recurrence or metastases had occurred. Conclusion: This is the first case of lymph node metastasis from a renal solitary fibrous tumor showing unusual malignant behavior; this finding adds new information about the biology and progression of these tumors, which remain unclear. Keywords: solitary fibrous tumor, sarcoma, kidney, lymph node metastases, lymphadenectomy

  18. CT in malignant primary soft tissue tumours

    International Nuclear Information System (INIS)

    The results of CT examinations in 36 patients suffering from histologically confirmed malignant primary tumours of the soft tissues are presented (6 rhabdomyosarcomas, 4 leiomyosarcomas, 6 liposarcomas, 4 malignant schwannomas, 5 malignant fibrous histiocytomas, 4 malignant haemangiopericytomas, 3 angiosarcomas, 1 fibrosarcoma, 1 renal sarcoma, 2 malignant mesenchymal tumours without histologically clear classification). The CT image alone will not yield information on the type of tumour or on the tumour status. However, CT continues to rank in the diagnosis of tumours of the soft tissues and is even superior to MR especially in the identification of gas accumulations due to infection in a tumour of the soft tissues that is otherwise unclear. Comparing the literature conclude that MR is now the imaging method of choice in the diagnosis of soft tissue tumours. (orig.)

  19. Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas

    DEFF Research Database (Denmark)

    Jensen, V; S酶rensen, Flemming Brandt; Bentzen, S M; Ladekarl, M; Nielsen, O S; Keller, J; Jensen, O M

    1998-01-01

    AIMS: To evaluate the prognostic value of tumour proliferative activity, p53 accumulation and bcl-2 expression in a retrospective series of 216 patients with soft tissue sarcomas (STS). METHODS AND RESULTS: The immunohistochemical analyses were performed on formalin-fixed, paraffin-embedded tissu...

  20. Thermochemoradiotherapy for head and neck advanced malignant tumors

    International Nuclear Information System (INIS)

    Ten patients with advanced malignant tumor of head and neck were treated by combined treatment with chemoradiotherapy and hyperthermia. Histopathologically, squamous cell carcinoma was diagnosed in 7 patients, adenocarcinoma in 1, osteosarcoma in 1, and malignant fibrous histiocytoma in 1. The heating device was RF capacitive heating of external heating and magnetic induction hyperthermia of interstitial heating. Chemotherapy of high-dose MTX was used for osteosarcoma and malignant fibrous histiocytoma, and low-dose cisplatin was used for squamous cell carcinoma. Four patients with advanced malignant tumor of the primary lesion underwent thermochemoradiotherapy. Six patients with metastatic lymph nodes of N3 underwent preoperative thermochemoradiotherapy. As a result for primary lesion, CRh was observed in 1 patient, PRh in 2, and NCh in 1. And as results of clinical response and pathological response for metastatic lymph nodes of N3, PRh was observed in all 6 patients, and Gr. III in 1, Gr. II b in 3, Gr. II a in 2. The four-year cumulative survival rate of patients with metastatic lymph nodes on N3 was 50.0%. Combined preoperative chemoradiotherapy and hyperthermia was an effective therapeutic method for treating patients with metastatic lymph nodes of N3. (author)

  1. Primary malignant bone tumors: diagnosis, radiological appearance and therapy; Primaer maligne Knochentumoren: Klinik und Therapie

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    Dominkus, M.; Kotz, R. [Universitaetsklinik fuer Orthopaedie, Wien (Austria); Kainberger, F. [Abt. fuer Osteoradiologie, Universitaetsklinik fuer Radiologie, Wien (Austria); Lang, S. [Wien Univ. (Austria). Universitaetsklinik fuer Pathologische Anatomie

    1998-06-01

    Diagnosis, concepts of therapy and prognosis of primary malignant bone tumors require intensive cooperation between orthopedic surgeons, radiologists and pathologists with special knowledge in oncology. The present paper demonstrates relevant topics of diagnosis, radiological appearance and therapy of the osteosarcoma, Ewing`s sarcoma, chondrosarcoma and malignant fibrous histiocytoma based on the material of the Vienna Bone Tumor Registry and more than 35 years of cooperation between the Institute of Pathology and Anatomy and the Department of Orthopedics at the University of Vienna. (orig.) [Deutsch] Fuer die Diagnose, Therapieplanung und Prognosebeurteilung von primaer malignen Knochentumoren ist eine intensive Kooperation von onkologisch speziell ausgebildeten Fachdisziplinen wie Orthopaedie, Radiologie und Pathologie erforderlich. Die vorliegende Arbeit basiert auf dem Material des Wiener Knochengeschwulstregisters und der 35jaehrigen Zusammenarbeit des Pathologisch/Anatomischen Instituts der Universitaet Wien mit der Universitaetsklinik fuer Orthopaedie und beschreibt Diagnose, radiologisches Erscheinungsbild und Therapie der 4 haeufigsten primaer malignen Knochentumoren: Osteosarkom, Ewing`s Sarkom, Chondrosarkom und malignes fibroeses Histiozytom. (orig.)

  2. Rapid recurrence and bilateral lungs, multiple bone metastasis of malignant solitary fibrous tumor of the right occipital lobe: report of a case and review

    OpenAIRE

    Wu, Zhengrong; Yang, Hongjun; Weng, Desheng; Ding, Yanqing

    2015-01-01

    Background Intracranial malignant solitary fibrous tumor (MSFT) is extremely rare. The authors report a case of MSFT of the right occipital lobe with a rapid recurrence and bilateral lung, multiple bone metastasis. Case presentation The patient was a 25-year-old male presenting with headache, nausea and visual disturbances without obvious cause. Three times right-side occipital craniotomies were performed and two times postoperative conformal radiotherapy were administered within one year. 4聽...

  3. De novo malignant transformation of giant cell tumor of bone

    International Nuclear Information System (INIS)

    Two cases of malignant lesions are reported, both of which arose secondary to an originally benign giant cell tumor (GCT) of bone. The first case was a typical benign GCT, which occurred in the left proximal tibia of a 31-year-old woman. The tumor was treated by curettage and bone grafting. However, it recurred twice during 15 years of follow-up. The second recurrence showed that the lesion histologically had turned into malignant fibrous histiocytoma. The second case also started as an initially benign GCT that arose in the left distal femur of a 41-year-old man. The patient underwent curettage and bone grafting. The lesion recurred 13 years postoperatively. The histological appearance of the recurrent tumor showed it to be an osteogenic sarcoma. In both patients, radiation had never been given. Malignant transformation has rarely been reported in patients with GCT of bone who have not received radiation treatment. (orig.)

  4. Doege-Potter syndrome presenting with hypoinsulinemic hypoglycemia in a patient with a malignant extrapleural solitary fibrous tumor: a case report

    Directory of Open Access Journals (Sweden)

    Schutt Robert C

    2013-01-01

    Full Text Available Abstract Introduction Doege-Potter syndrome is a paraneoplastic syndrome characterized by non-islet cell tumor hypoglycemia secondary to a solitary fibrous tumor. This tumor causes hypoglycemia by the secretion of a prohormone form of insulin-like growth factor II. We describe the diagnosis and management of Doege-Potter syndrome and the use of transarterial chemoembolization in a patient with a malignant extrapleural solitary fibrous tumor. Case presentation Our patient was a 64-year-old Caucasian woman who initially presented with urinary incontinence and was found to have a 14.59.09.0cm retroperitoneal solitary fibrous tumor compressing her bladder. Her tumor was surgically resected but recurred with multiple hepatic metastatic lesions. The hepatic metastases progressed despite systemic chemotherapy and treatment with doxorubicin transarterial chemoembolization. Her course was complicated by the development of recurrent fasting hypoglycemia, most likely secondary to Doege-Potter syndrome. Her hypoglycemia was managed with corticosteroid therapy and frequent scheduled nutrient intake overnight. Conclusions The rarity of hepatic solitary fibrous tumors and consequent lack of controlled trials make this report significant in that it describes the diagnostic approach to Doege-Potter syndrome, describes our experience with the use of doxorubicin transarterial chemoembolization, and presents management options for tumor-associated hypoglycemia in the case of extensive disease not amenable to surgical resection.

  5. Ionizing radiation induced malignancies in man

    International Nuclear Information System (INIS)

    Using data on gene and chromosome alterations in human cancers, it is proposed that most radiation induced cancers are a consequence of recessive mutations of tumor suppressor genes. This explains the long delay between radiation exposure and the cancer onset. As a consequence, radiation induced cancers belong to groups of tumors where no specific translocations (forming or activating oncogenes) but multiple unbalanced chromosome rearrangements (deletions unmasking recessive mutations) exist. This explains why osteosarcomas, malignant fibrous histiocytoma, chondrosarcomas are frequently induced, but not liposarcoma, Ewing sarcomas and rhabdomyosarcomas, among others. A single exception confirms this rule: papillary thyroid cancer, frequently induced in exposed children, in which structural rearrangements frequently form a RET/PTC3 fusion gene. This fusion gene is the results of the inversion of a short segment of chromosome 10, and it is assumed that such rearrangement (small para-centric inversion) can easily occur after exposure to radiations, at contrast with translocations between to genes belonging to different chromosomes. (author)

  6. Neurofibromatosis type 1 and malignancy in childhood.

    Science.gov (United States)

    Varan, A; ?en, H; Ayd?n, B; Yal?n, B; Kutluk, T; Aky鼁, C

    2016-03-01

    Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary neurocutaneous syndrome characterized by multi-system involvement and an increased incidence of both benign and malignant tumors. In this study, we evaluated the clinical presentation and prognosis of NF1 and malignancy. Between 1975 and 2013, 26 (5%) of the 473 patients with NF1 at our center developed non-neurofibroma neoplasms. The patient files of 26 subjects with tumors, other than optic glioma, were analyzed retrospectively to evaluate clinical features and treatment results. The age at diagnosis of NF1 ranged from 3 months to 16 years (median 5.5 years). The age range at tumor diagnosis was 1.5-33 years (median 8 years) in these 26 patients. The tumor histological subtypes included the following: 12 soft-tissue tumors (6 malignant peripheral nerve sheath tumors (MPNST), 5 rhabdomyosarcomas (RMS) and 1 malignant fibrous histiocytoma), 11 brain tumors (6 low-grade gliomas, 3 high-grade gliomas, and 2 medulloblastoma), 2 neuroblastomas and 1 non-Hodgkin's lymphoma. Twelve of 26 patients were alive at the time of the study. Although benign brain tumors with NF1 are more common, high-grade brain tumors also occur. Thus, careful and regular follow-up is crucial for early detection of malignancy in NF1 patients. PMID:26073032

  7. Solitary fibrous tumor of the orbit.

    Science.gov (United States)

    Gupta, Sumiti; Verma, Renuka; Sen, Rajeev; Singh, Ishwar; Marwah, Nisha; Kohli, Rachneet

    2016-01-01

    Solitary fibrous tumor (SFT) is a rare spindle-cell neoplasm originating from the mesenchyme. It was originally thought to occur exclusively in the intrathoracic region but has been recently described in extrapleural sites including the orbit. SFT of the orbit is a rare lesion, which can be misdiagnosed as hemangiopericytoma, fibrous histiocytoma, meningioma, or neurofibroma. Immunohistochemistry plays an important role. We report an orbital SFT in a 39-year-old female presented with painless, progressive proptosis, and diminished vision in the right eye for the duration of 6 months. Magnetic resonance imaging demonstrated well-defined enhancing mass lesion. The patient underwent complete tumor removal through a right fronto-orbital approach, and a pathological diagnosis of the solitary fibrous tumor was made. Postoperatively, the patient was symptom-free. Clinical and pathological findings including immunohistochemistry are presented along with a brief discussion of literature. PMID:26889300

  8. Subungual Acral Fibromyxoma Involving the Bone: A Mimicker of Malignancy.

    Science.gov (United States)

    Carranza, Carmen; Molina-Ruiz, Ana Mar韆; P閞ez de la Fuente, Teresa; Kutzner, Heinz; Requena, Luis; Santonja, Carlos

    2015-07-01

    Superficial acral fibromyxoma (SAF) is a recently recognized myxoid tumor that usually occurs on the fingers and toes of middle-aged adults. We report the case of a 53-year-old man with a SAF on the first left toe that had been slowly growing for 2 years. Hispathologically, the lesion was nonencapsulated and was composed of stellate and spindle cells, arranged in a myxoid matrix. No atypia or mitotic figures were found. Neoplastic cells showed positive staining for CD34 and negative staining for epithelial membrane antigen, actin, desmin, keratins, S-100 protein, and HMB45. Main differential diagnoses of SAF include benign and malignant myxoid and spindle cells tumors, such as myxoid fibrous histiocytoma, superficial angiomyxoma, myxoid neurofibroma, myxoid dermatofibrosarcoma protuberans, and low-grade fibromyxoid sarcoma. PMID:25062265

  9. Special diagnostic problems in primary malignant bone tumors

    International Nuclear Information System (INIS)

    The diagnosis of primary malignant bone tumors, which only account for 1% of malignancies in humans, represents quite a challange for the pathologist. Apart from the often overlapping morphology between different entities, heterogeneity within one and the same tumor has to be kept in mind. Furthermore, in most cases the diagnosis must be established based on small biopsy specimens and occasionally even on frozen sections. In this context detailed clinical information including the patient's age and exact localization of the tumor, as depicted by X-ray or MRI, are essential requirements for a correct diagnosis. In addition, multiple biopsies from different tumor sites may be of help. For example, 25% of osteogenic sarcomas (OSA) are chondroplastic. Others may contain areas similar to fibrosarcoma (FSA) or malignant fibrous histiocytoma (MFH). Since 90% of OSA occur in the second decade of life whereas chondrosarcomas, FSA and MFH usually manifest after the age of 40 years, a biopsy solely composed of malignant chondromatous tissue obtained from a tibial lesion of a 10-year-old child should most likely be considered as part of an OSA. In the differential diagnosis of the so-called small, round cell tumors, which include Ewing sarcoma, malignant lymphoma and small-cell OSA, immunohistochemical staining of the paraffin-embedded material and a molecular biological/genetic work-up of frozen material are most helpful. In this paper the histomorphological characteristics and criteria for differential diagnosis of the most common primary malignant bone tumors are discussed. (orig.)

  10. CT findings of uncommon malignant tumors of the liver

    International Nuclear Information System (INIS)

    Objective: To improve the diagnostic level of uncommon hepatic malignancy in 5 cases with different histopathological nature by analyzing their CT features. Methods: CT scan was performed in 5 cases with pathologically proved uncommon malignancy of the liver including hepatic sarcoma (n=3) and primary carcinoid tumor (n=2). Results: These uncommon malignancies of the liver had a variety of presentations. Undifferentiated embryonal sarcoma presented as a single huge cyst mixing with solid mass. Hepatic angiosarcoma demonstrated as multiple well-defined hypoattenuation lesions without cirrhosis. Necrosis, cystic degeneration, and hemorrhage may be accompanied. Malignant fibrous histiocytoma displayed as a single large hypoattenuation lesion within hyperdense septations, and most of the tumor was in the right lobe. Immunohistochemistry had the diagnostic value. The CT features of carcinoid tumor were single or multiple, unilocular or multilocular mixed-dense masses. The solid portion of the masses enhanced obviously and carcinoid syndrome may highly suggest the diagnosis. Conclusion: The forementioned 5 cases of hepatic malignancy are seldom seen clinically. Each of them with different pathologic nature has different CT findings, and sometimes with some similar signs. Typical CT findings, coupled with clinical information may lead to a correct diagnosis

  11. Massive chest wall resection and reconstruction for malignant disease

    Science.gov (United States)

    Foroulis, Christophoros N; Kleontas, Athanassios D; Tagarakis, George; Nana, Chryssoula; Alexiou, Ioannis; Grosomanidis, Vasilis; Tossios, Paschalis; Papadaki, Elena; Kioumis, Ioannis; Baka, Sofia; Zarogoulidis, Paul; Anastasiadis, Kyriakos

    2016-01-01

    Objective Malignant chest wall tumors are rare neoplasms. Resection with wide-free margins is an important prognostic factor, and massive chest wall resection and reconstruction are often necessary. A recent case series of 20 consecutive patients is reported in order to find any possible correlation between tumor histology, extent of resection, type of reconstruction, and adjuvant treatment with short- and long-term outcomes. Methods Twenty patients were submitted to chest wall resection and reconstruction for malignant chest wall neoplasms between 2006 and 2014. The mean age (ten males) was 59卤4 years. The size and histology of the tumor, the technique of reconstruction, and the short- and long-term follow-up records were noted. Results The median maximum diameter of tumors was 10 cm (5.4鈥32 cm). Subtotal sternal resection was performed in nine cases, and the resection of multiple ribs was performed in eleven cases. The median area of chest wall defect was 108 cm2 (60鈥340 cm2). Histology revealed soft tissue, bone, and cartilage sarcomas in 16 cases (80%), most of them chondrosarcomas. The rest of the tumors was metastatic tumors in two cases and localized malignant pleural mesothelioma and non-Hodgkin lymphoma in one case. The chest wall defect was reconstructed by using the 鈥渟andwich technique鈥 (propylene mesh/methyl methacrylate/propylene mesh) in nine cases of large anterior defects or by using a 2 mm polytetrafluoroethylene (e-PTFE) mesh in nine cases of lateral or posterior defects. Support from a plastic surgeon was necessary to cover the full-thickness chest wall defects in seven cases. Adjuvant oncologic treatment was administered in 13 patients. Local recurrences were observed in five cases where surgical reintervention was finally necessary in two cases. Recurrences were associated with larger tumors, histology of malignant fibrous histiocytoma, and initial incomplete resection or misdiagnosis made by nonthoracic surgeons. Three patients died during the study period because of recurrent disease or complications of treatment for recurrent disease. Conclusion Chest wall tumors are in their majority mesenchymal neoplasms, which often require major chest wall resection for their eradication. Long-term survival is expected in low-grade tumors where a radical resection is achieved, while big tumors and histology of malignant fibrous histiocytoma are connected with the increase rate of recurrence. PMID:27143930

  12. Quantification of the magnetization-transfer contrast effect: can it yield additional information in differentiation of musculoskeletal lesions particularly in separation of benign from malignant lesions

    International Nuclear Information System (INIS)

    Purpose: To investigate the potential information of the amount of magnetization-transfer effect in musculoskeletal lesions and to compare MT ratios from benign and malignant musculoskeletal lesions. Material and Method: 49 patients with malignant tumors (3 osteosarcoma, 3 malignant fibrous histiocytoma, 4 chondrosarcoma, 2 Ewing sarcomas) and benign lesions (8 chondroma, 2 fibrous dysplasia, 3 osteoid-osteoma, 6 ganglion cyst, 3 cyst, 3 osteomyelitis, 4 tendinitis, 3 rotator cuff tear, 5 scar tissue) were scanned using routine MRI protocols including T1- and T2-weighted spin echo as well as T2*-weighted gradient echo (FFE) sequences at 1.5 Tesla (ACS II, Philips Medical). Additionally MTC images were generated by combining the FFE sequence and the off-resonance MT technique (-1500 Hz off-resonance frequency, 1770 flip angle and 50 ms pulse duration). MT ratios were calculated as SIo-SIm/SIo. Results: The MT ratio of benign lesions was 26卤15%, that of malignant lesions was 22卤6%. The difference was statistically not significant. As expected muscle showed a high MT ratio of 50卤8%. Scar tissue demonstrated an MT ratio of 39卤16% which was significantly higher than the tumor MT ratios. Conclusion: MTC (MT ratios) failed to show significant differences between benign and malignant lesions as was expected due to basic differences in cellularity, rate of mitosis and chromatin content. MTC might however gain more importance in separating scar tissue from recurrent tumor in the future. (orig.)

  13. Fibrous dysplasia of bone.

    Science.gov (United States)

    Chapurlat, R D; Meunier, P J

    2000-06-01

    Fibrous dysplasia of bone is a disease that can involve one or several bones and is characterized by bone deformities, pain and iterative fractures. Some patients can present with endocrine dysfunction (generally precocious puberty) and cutaneous caf-au-lait spots. Some complications, such as nerve compression and malignant transformation, are uncommon. Many patients can, however, be asymptomatic. Diagnosis relies on X-ray examination and pathology. Prognosis is assessed by X-rays and markers of bone remodelling. Several breakthroughs in the understanding of the pathophysiology have been made in the past 10 years. It is now recognized that fibrous dysplasia is caused by a somatic activating mutation of the Gs alpha subunit of protein G, resulting in an increased cAMP concentration and thus in abnormalities of osteoblast differentiation, these osteoblasts producing abnormal bone. There is also an increase in interleukin-6-induced osteoclastic bone resorption, which is the rationale for treating these patients with bisphosphonates. In the past 10 years, the bisphosphonate pamidronate has been used by infusion for fibrous dysplasia (two courses per year), with good results with respect to pain and, in about 50% of patients, the refilling of osteolytic lesions. PMID:10925751

  14. Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics.

    Science.gov (United States)

    Doyle, Leona A; Vivero, Marina; Fletcher, Christopher Dm; Mertens, Fredrik; Hornick, Jason L

    2014-03-01

    Solitary fibrous tumor (SFT) is composed of spindled to ovoid cells in a patternless architecture with prominent stromal collagen and hemangiopericytoma-like vessels. Some tumors show hypercellularity, nuclear atypia, and significant mitotic activity; the latter feature in particular often portends an aggressive clinical course. SFT can sometimes be difficult to distinguish from other benign mesenchymal tumors and sarcomas. The most characteristic (albeit nonspecific) immunohistochemical finding in SFT is CD34 expression. A NAB2-STAT6 gene fusion, resulting in a chimeric protein in which a repressor domain of NGFI-A binding protein 2 (EGR1 binding protein 2) (NAB2) is replaced with a carboxy-terminal transactivation domain from signal transducer and activator of transcription 6, interleukin-4 induced (STAT6), was recently identified as a consistent finding in SFT. However, as these genes are located in close proximity on 12q13, this fusion can only rarely be detected by conventional chromosomal banding or fluorescence in situ hybridization analysis. Nuclear expression of the carboxy terminal part of STAT6 is a consistent finding in SFT of the meninges (so-called 'meningeal hemangiopericytoma'). We investigated STAT6 expression by immunohistochemistry in SFTs and other soft tissue tumors arising outside the central nervous system to validate the diagnostic utility of this novel marker. Whole-tissue sections of 231 tumors were evaluated, including 60 cases of SFT as well as other benign and malignant mesenchymal neoplasms and sarcomatoid mesotheliomas. Fifty-nine of 60 SFT cases (98%) showed nuclear expression of STAT6, which was usually diffuse and intense. All other tumor types were negative for STAT6, except for three dedifferentiated liposarcomas and one deep fibrous histiocytoma, which showed weak staining. In conclusion, STAT6 is a highly sensitive and almost perfectly specific immunohistochemical marker for SFT and can be helpful to distinguish this tumor type from histologic mimics. PMID:24030747

  15. The Study of the Malignant Tumors of the Maxillary Sinus by Computed Tomography

    International Nuclear Information System (INIS)

    CT findings of proven 25 malignant tumors of the maxillary sinus were retrospectively analyzed to be of help in the diagnosis and treatment. The results were as follow: 1. Average age was 54 years old, and eighteen were males and seven were females with a ratio of 2.6:1. 2. The most common histopathologic feature was squamous cell carcinoma (19 cases) and others were two cases of adenoid cystic carcinoma, one case of malignant fibrous histiocytoma, mucoepidermoid tumor, histiocytic lymphoma, unidentified malignant tumor. 3. CT findings were sinus opacification (4%), soft tissue mass (92%), low densities within soft tissue mass (44%), air densities within soft tissue mass (24%), osteosclerosis (4%), bone destruction (92%), bone displacement (32%), fat plane obliteration(76%). 4. CT in the malignant maxillary sinus tumors approved the value in evaluation of tumor extension to nasal cavity, ethmoid sinus, orbit, infratemporal fossa, pterygopalatine fossa, pterygoid fossa, pterygoid muscle, cheek skin and intracranial cavity. 5. Twenty four cases (96%) were stage III, stage IV according to AJCC TNM classification. 6. Bone findings were destruction, displacement, sclerosis and most frequent site of bone destruction was the medial wall of the antrum (92%). 7. Tumor growth pattern showed destructive pattern in 18 cases (72%), and squamous cell carcinoma showed destructive pattern. (p<0.05).

  16. The Study of the Malignant Tumors of the Maxillary Sinus by Computed Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Dan, Jung Bae; Park, Tae Won [Dept. of Oral Radiology, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

    1989-11-15

    CT findings of proven 25 malignant tumors of the maxillary sinus were retrospectively analyzed to be of help in the diagnosis and treatment. The results were as follow: 1. Average age was 54 years old, and eighteen were males and seven were females with a ratio of 2.6:1. 2. The most common histopathologic feature was squamous cell carcinoma (19 cases) and others were two cases of adenoid cystic carcinoma, one case of malignant fibrous histiocytoma, mucoepidermoid tumor, histiocytic lymphoma, unidentified malignant tumor. 3. CT findings were sinus opacification (4%), soft tissue mass (92%), low densities within soft tissue mass (44%), air densities within soft tissue mass (24%), osteosclerosis (4%), bone destruction (92%), bone displacement (32%), fat plane obliteration(76%). 4. CT in the malignant maxillary sinus tumors approved the value in evaluation of tumor extension to nasal cavity, ethmoid sinus, orbit, infratemporal fossa, pterygopalatine fossa, pterygoid fossa, pterygoid muscle, cheek skin and intracranial cavity. 5. Twenty four cases (96%) were stage III, stage IV according to AJCC TNM classification. 6. Bone findings were destruction, displacement, sclerosis and most frequent site of bone destruction was the medial wall of the antrum (92%). 7. Tumor growth pattern showed destructive pattern in 18 cases (72%), and squamous cell carcinoma showed destructive pattern. (p<0.05).

  17. Prevalence of Malignant Soft Tissue Tumors inExtremities: An Epidemiological Study in Syria

    Directory of Open Access Journals (Sweden)

    Habib Reshadi

    2014-06-01

    Full Text Available Background: 聽 Although the majority of soft tissue masses are benign, it is important to consider malignancy in differential diagnoses. Because most soft tissue sarcomas present as a painless mass, clinicians must watch for signs suggestive of malignancy, including large size, rapid growth, and site deep into the deep fascia.The purpose of this study was to determine the relative prevalence according to sex and age, site of tumor, skeletal distribution, and treatment (surgery, chemotherapy and radiotherapy before and after surgery, and ascertain the relative frequency of these tumors in specific anatomic sites and age groups based on pathological studies. Methods: A total of 308 patients, with a musculoskeletal tumor were evaluated retrospectively. All of the patients enrolled into this study were referred to the Beirouni Hospital of Damascus University with a proven diagnosis of alignant soft tissue tumors from the beginning of January 2008 until the end of 2010. The prevalence of the malignant soft tissue tumors in these patients was analyzed. For purposes of analysis, all lesions were placed in 1 of 9 categories: hand and wrist, forearm, humorous (arm, proximal limb girdle (axilla and shoulder, foot and ankle, thigh, hip and buttocks region, trunk, and other lesions. Age and sex also were recorded. Results: Malignant tumors consisted of seven diagnostic categories: malignant fibrous histiocytoma (23%, liposarcoma (22%, rhabdomyosarcoma (9%, leiomyosarcoma (8%, malignant schwannoma (5%, dermatofibrosarcoma protuberans (5%, synovial sarcoma (10%, fibrosarcoma (13%, extraskeletal chondrosarcoma (1%, and extraskeletal Ewing sarcoma (4%. Conclusions: Despite the multitude of pathologic possibilities, most malignant soft-tissue tumors are classified into a small number of diagnoses. These may be further defined when the site of the lesion and the age of the patient are considered. Knowledge of tumor prevalence will assist radiologists in establishing a suitably ordered differential diagnosis when a soft-tissue tumor has a nonspecific radiologic appearance. 聽 聽

  18. Massive chest wall resection and reconstruction for malignant disease

    Directory of Open Access Journals (Sweden)

    Foroulis CN

    2016-04-01

    Full Text Available Christophoros N Foroulis,1 Athanassios D Kleontas,1 George Tagarakis,1 Chryssoula Nana,1 Ioannis Alexiou,1 Vasilis Grosomanidis,1 Paschalis Tossios,1 Elena Papadaki,2 Ioannis Kioumis,2 Sofia Baka,3 Paul Zarogoulidis,2 Kyriakos Anastasiadis11Department of Cardiothoracic Surgery, Aristotle University School of Medicine, AHEPA University Hospital, 2Pulmonary Department-Oncology Unit, 鈥淕. Papanikolaou鈥 General Hospital, Aristotle University of Thessaloniki, 3Oncology Department, European Interbalkan Medical Center, Thessaloniki, GreeceObjective: Malignant chest wall tumors are rare neoplasms. Resection with wide-free margins is an important prognostic factor, and massive chest wall resection and reconstruction are often necessary. A recent case series of 20 consecutive patients is reported in order to find any possible correlation between tumor histology, extent of resection, type of reconstruction, and adjuvant treatment with short- and long-term outcomes.Methods: Twenty patients were submitted to chest wall resection and reconstruction for malignant chest wall neoplasms between 2006 and 2014. The mean age (ten males was 59卤4聽years. The size and histology of the tumor, the technique of reconstruction, and the short- and long-term follow-up records were noted.Results: The median maximum diameter of tumors was 10聽cm (5.4鈥32聽cm. Subtotal sternal resection was performed in nine cases, and the resection of multiple ribs was performed in eleven cases. The median area of chest wall defect was 108聽cm2 (60鈥340聽cm2. Histology revealed soft tissue, bone, and cartilage sarcomas in 16 cases (80%, most of them chondrosarcomas. The rest of the tumors was metastatic tumors in two cases and localized malignant pleural mesothelioma and non-Hodgkin lymphoma in one case. The chest wall defect was reconstructed by using the 鈥渟andwich technique鈥 (propylene mesh/methyl methacrylate/propylene mesh in nine cases of large anterior defects or by using a 2聽mm polytetrafluoroethylene (e-PTFE mesh in nine cases of lateral or posterior defects. Support from a plastic surgeon was necessary to cover the full-thickness chest wall defects in seven cases. Adjuvant oncologic treatment was administered in 13 patients. Local recurrences were observed in five cases where surgical reintervention was finally necessary in two cases. Recurrences were associated with larger tumors, histology of malignant fibrous histiocytoma, and initial incomplete resection or misdiagnosis made by nonthoracic surgeons. Three patients died during the study period because of recurrent disease or complications of treatment for recurrent disease.Conclusion: Chest wall tumors are in their majority mesenchymal neoplasms, which often require major chest wall resection for their eradication. Long-term survival is expected in low-grade tumors where a radical resection is achieved, while big tumors and histology of malignant fibrous histiocytoma are connected with the increase rate of recurrence.Keywords: chest wall tumors, chest wall resection, chest wall reconstruction, soft tissue sarcomas, sternal tumors, chondrosarcoma聽

  19. A case of congenital solitary Langerhans cell histiocytoma.

    LENUS (Irish Health Repository)

    Ricciardo, Bernadette

    2012-02-01

    A newborn baby boy was referred to the Paediatric Dermatology Unit with a solitary asymptomatic nodule overlying his right nasolabial fold. Complete physical examination, full blood count, serum chemistry, liver function tests and baseline imaging were unremarkable. Histopathological examination showed an atypical dermal infiltrate of mononuclear cells that stained positive with CD1a and S100. A diagnosis of congenital solitary Langerhans cell histiocytoma was made. The lesion completely resolved by 4 months of age. The baby is now 15 months old and repeat systemic evaluation has remained normal.

  20. Fibrous dysplasia of bone: a clinicopathologic review

    Directory of Open Access Journals (Sweden)

    Mohan H

    2011-11-01

    Full Text Available Harsh Mohan1, Preeti Mittal1, Irneet Mundi1, Sudhir Kumar21Department of Pathology, 2Department of Orthopedics, Government Medical College, Sector 32, Chandigarh, IndiaAbstract: Fibrous dysplasia of the bones is an uncommon congenital skeletal disorder that is found equally in both genders and is not inherited. Its etiology has been linked to an activating mutation of Gs伪 and the downstream effects of the resultant increase in cAMP. Fibrous dysplasia is categorized as either monostotic or polyostotic, and may occur as a component of McCune-Albright syndrome or the rare Mazabraud syndrome. Long bones, skull bones, and ribs are the most commonly affected bones. The radiological picture is somewhat variable, including a ground-glass appearance, expansion of the bone, and sclerosis surrounding the lesion. Histologically, fibrous dysplasia shows irregularly-shaped trabeculae of immature, woven bone in a background of variably cellular, loosely arranged fibrous stroma. It may be complicated by pathologic fracture, and rarely by malignant transformation. This review examines interesting issues surrounding the etiology of fibrous dysplasia, its clinical and laboratory manifestations, radiological picture, utility of bone biopsy, gross and microscopic pathology, complications, and its differential diagnostic considerations.Keywords: fibrous dysplasia, McCune-Albright syndrome, monostotic form, polyostotic form

  1. Development of a sarcoma in a surgical scar.

    OpenAIRE

    Sherlock, D. J.; Rickards, H.; Gardecki, T I; Hamer, J D

    1987-01-01

    The development of a malignant soft tissue tumour (malignant fibrous histiocytoma) in a surgical wound is reported. Although rare, this occurrence has important diagnostic implications and the management is discussed.

  2. Craniofacial fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Aakarsh Jhamb

    2012-01-01

    Full Text Available Fibrous dysplasia can present clinically in varied forms which may appear as collision of different pathologic processes. We report a rare case of craniofacial fibrous dysplasia with coexisting epithelial lined cyst and superimposed osteomyelitis with sequestrum formation. Its clinical features and management with possible hypotheses are described along with the post operative course. Pertinent literature has been reviewed with emphasis on pathogenesis of this unique occurrence.

  3. Strength of Fibrous Composites

    CERN Document Server

    Huang, Zheng-Ming

    2012-01-01

    "Strength of Fibrous Composites" addresses evaluation of the strength of a fibrous composite by using its constituent material properties and its fiber architecture parameters. Having gone through the book, a reader is able to predict the progressive failure behavior and ultimate strength of a fibrous laminate subjected to an arbitrary load condition in terms of the constituent fiber and matrix properties, as well as fiber geometric parameters. The book is useful to researchers and engineers working on design and analysis for composite materials. Dr. Zheng-Ming Huang is a professor at the School of Aerospace Engineering & Applied Mechanics, Tongji University, China. Mr. Ye-Xin Zhou is a PhD candidate at the Department of Mechanical Engineering, the University of Hong Kong, China.

  4. Intraperitoneal solitary fibrous tumor.

    Science.gov (United States)

    Benabdejlil, Youssef; Kouach, Jaouad; Babahabib, Abdellah; Elhassani, Moulay Elmehdi; Rharassi, Issam; Boudhas, Adil; Bakkali, Hicham; Elmarjany, Mohammed; Moussaoui, Driss; Dehayni, Mohamed

    2014-01-01

    Solitary fibrous tumors of the pelvis are rare. We report the case of a 32-years-old patient who presented with abdominopelvic mass. The imaging studies showed a right adnexal mass of more than 10鈥塩m. Exploratory laparotomy revealed a 20鈥塩m mass at the Douglas pouch which was adhered to the posterior wall of the uterus. Complete resection of the mass was performed. Histological analysis showed a spindle cell undifferentiated tumor whose morphological and immunohistochemical profile are consistent with solitary fibrous tumor. It is important to know that although these tumors are rare, their evolution can be pejorative. Therefore, long-term followup should be recommended. PMID:25276449

  5. Primary intracranial angiomatoid fibrous histiocytoma presenting with anaemia and migraine-like headaches and aura as early clinical features

    DEFF Research Database (Denmark)

    Hansen, Jakob M酶ller; Larsen, Vibeke Andr茅e; Scheie, David; Perry, Arie; Skj酶th-Rasmussen, Jane

    2015-01-01

    A 17-year-old female with migraine with aura complained of fatigue and was diagnosed with anemia. Three years later, changes in her headache pattern prompted hospital referral. Brain MRI showed a bi-lobed extra-axial intracerebral tumor encroaching both parieto-occipital regions. The resection sp...

  6. Intraarterial Chemotherapy for Extremity Osteosarcoma and MFH in Adults

    OpenAIRE

    Hugate, Ronald R.; Wilkins, Ross M.; Kelly, Cynthia M.; Madsen, Walt; Hinshaw, Ioana; Camozzi, Anne B.

    2008-01-01

    The neoadjuvant treatment of osteosarcoma using intravenous agents has resulted in survival rates of 55% to 77% [3, 5, 6, 20, 22, 35]. We designed a neoadjuvant chemotherapy protocol using combined intraarterial and intravenous agents to treat high-grade osteosarcoma and malignant fibrous histiocytoma of bone in an attempt to improve survival. We report the results of treating 53 adults (age 18鈥77聽years) diagnosed with nonmetastatic extremity osteosarcoma or malignant fibrous histiocytoma. Pr...

  7. Intraperitoneal Solitary Fibrous Tumor

    OpenAIRE

    Youssef Benabdejlil; Jaouad Kouach; Abdellah Babahabib; Moulay Elmehdi Elhassani; Issam Rharassi; Adil Boudhas; Hicham Bakkali; Mohammed Elmarjany; Driss Moussaoui; Mohamed Dehayni

    2014-01-01

    Solitary fibrous tumors of the pelvis are rare. We report the case of a 32-years-old patient who presented with abdominopelvic mass. The imaging studies showed a right adnexal mass of more than 10鈥塩m. Exploratory laparotomy revealed a 20鈥塩m mass at the Douglas pouch which was adhered to the posterior wall of the uterus. Complete resection of the mass was performed. Histological analysis showed a spindle cell undifferentiated tumor whose morphological and immunohistochemical profile are consis...

  8. Fibrous Pseudotumour of the Testis

    Directory of Open Access Journals (Sweden)

    Geetha Vasudevan

    2013-08-01

    Full Text Available Fibrous pseudotumour of the testis is a rare benign lesion involving the paratesticular region. It usually presents in nodular form and may cause diagnostic dilemma resulting in unnecessary sacrifice of the testes. We report a rare case of diffuse fibrous pseudotumour which had to be treated by orchiectomy. [J Interdiscipl Histopathol 2013; 1(4.000: 227-229

  9. Fibrous Pseudotumour of the Testis

    OpenAIRE

    Geetha Vasudevan; Bhavna Nayal; Lakshmi Rao

    2013-01-01

    Fibrous pseudotumour of the testis is a rare benign lesion involving the paratesticular region. It usually presents in nodular form and may cause diagnostic dilemma resulting in unnecessary sacrifice of the testes. We report a rare case of diffuse fibrous pseudotumour which had to be treated by orchiectomy. [J Interdiscipl Histopathol 2013; 1(4.000): 227-229

  10. Rare solitary fibrous tumor of the stomach: A case report

    Directory of Open Access Journals (Sweden)

    Bo拧kovi膰 Tamara

    2015-01-01

    Full Text Available Introduction. Solitary fibrous tumors are rare soft tissue tumors of submesothelial origin and variable malignant potential. The most common localization is pleural, whereas only 0.6% are of extrapleural localization. Solitary fibrous tumor of the peritoneum, especially of gastric serosa is an extremely rare form of this tumor. Case report. We presented a 65- year-old female patient with solitary fibrous tumor of the stomach. Histopathological analysis of removed tissue showed the presence of tumor tissue built of spindle cells, elongated nuclei with moderately abundant cytoplasm. Cells were in a noncohesive arrangement, in smaller areas distributed in the form of palisade. There were amounts of hipocellular connective tissue, hyalinised, with small foci of dystrophic calcification. Mitoses were rare (less than 3/10 HPF. Blood vessels surrounded the connective tissue. Reviewed material did not contain elements of the parent organ. Immunohistochemically there were positivity on CD34 and vimentin, and negativity to S100, SMA, CD117, dezmin, and Ki-67 is < 2%. The change was diagnosed as a solitary fibrous tumor. Conclusion. Considering that benign solitary fibrous tumors of extrathoracic localizations are extremely rare neoplasms with unpredictable biological behavior and the possibility of recurrence, a long-term clinical and endoscopic follow-up on yearly basis of patients with this disease is recommended.

  11. Fibrous Pseudotumor of the Tunica Vaginalis Associated With Hydrocele and Testicular Atrophy

    Directory of Open Access Journals (Sweden)

    Pande Made Wisnu Tirtayasa

    2014-07-01

    Full Text Available Fibrous pseudotumors of the testicular tunics and paratesticular tissue are uncommon lesions. They typically arise as painless scrotal masses that may be associated with hydrocele or history of surgery, trauma, or infection. Although benign, these lesions often clinically indicate malignancy and usually remain undiagnosed preoperatively. Here, we report on a 59-year-old man with fibrous pseudotumor of the tunica vaginalis associated with hydrocele and testicular atrophy.

  12. Case of retroperitoneal solitary fibrous tumor.

    Science.gov (United States)

    Yamashita, Shinichi; Tochigi, Tatsuo; Kawamura, Sadafumi; Aoki, Hiroshi; Tateno, Hiroo; Kuwahara, Masaaki

    2007-07-01

    Solitary fibrous tumor (SFT) of the retroperitoneal space is rare. We report a case of retroperitoneal tumor, diagnosed as SFT. A 69-year-old woman presented with right lower abdominal swelling, and was referred to our hospital with suspicion of right renal tumor. Abdominal ultrasound and computerized tomography (CT) showed a mass (about 15 x 14 x 10 cm) in the right abdomen. The tumor was thought to be right renal rumor, and right radical nephrectomy was performed. In the excised specimen the tumor was not connected to gastrointestinal tract, peritoneum, or right kidney. The histological and immunohistochemical examination of the specimen revealed SFT. The tumor has malignant potential with partially increased mitotic activity and cellularity in the histological examination. The patient is healthy and without evidence of recurrence or metastasis 26 months from surgery. PMID:17702181

  13. Calcified fibrous pseudotumor of spermatic cord

    International Nuclear Information System (INIS)

    Paratesticular tumors are infrequent and most are benigns. This a case presentation of a patient aged 24 with a history of good health coming to our consultation by presence of a hard and painless 4 cm tumor in right scrotum with a 6 months course. Scrotal ultrasound (US) showed a well circumscribed heterogeneous lesion separate of epididymis and the testis. Fine needle aspiration biopsy (FNAB) was not possible by hardness of tumor. A inguinal surgery was performed and the total tumor exeresis using freezing biopsy negative of malignancy. Final histopathological report was: calcified fibrous pseudotumor of spermatic cord. Patient's course has been satisfactory. Significance of inguinal surgery was confirmed for the paratesticular tumor approach, even more when FNAB it is not conclusive for diagnosis.(author)

  14. Solitary fibrous tumor of the pancreas.

    Science.gov (United States)

    Baxter, Andrew R; Newman, Elliot; Hajdu, Cristina H

    2015-01-01

    Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms of fibroblastic origin. Most commonly they affect the pleura but they been described in other viscera. SFT of the pancreas is extremely rare, and only eight cases have been reported to date. We perform a literature review and report a ninth case. The patient is a 54-year-old African-American female who presented with several months of abdominal pain. Abdominal radiography demonstrated a lesion in the head of the pancreas, and she underwent a Whipple operation. Pathology demonstrated SFT of the pancreas. She is alive and well 1 year post-operatively. SFT of the pancreas predominately affects middle-aged women. These tumors are difficult to distinguish radiologically from neuroendocrine tumors. While SFT of the pancreas tend to have an indolent course, there is the potential for malignancy. We recommend complete surgical excision. PMID:26628714

  15. Tuberous sclerosis and fibrous dysplasia.

    Science.gov (United States)

    Gasparetto, Emerson L; de Carvalho Neto, Arnolfo; Bruck, Isac; Antoniuk, Sergio

    2003-05-01

    We present the case of an 11-year-old female patient with tuberous sclerosis who had a right nasal mass. CT examination revealed fibrous dysplasia involving the frontal, ethmoid, sphenoid, and vomer bones. Biopsy findings of the mass confirmed this diagnosis, and follow-up revealed marked expansion of these lesions. The authors emphasize the association of bone abnormalities and tuberous sclerosis and discuss the consideration of fibrous dysplasia as a component of this syndrome. PMID:12748080

  16. Diagnostic value of FDG PET-CT for detecting primary breast malignancy: comparison with other image modalities and histopathologic correlation

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Na Young; Lee, Jae Hee; Kim, Chung Ho; Yoo, Ie Ryung; Kim, Sung Hoon; Chung, Yong An; Sohn, Hyung Sun; Chung, Soo Kyo; Jung, Sang Seol [College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of)

    2004-07-01

    To compare the diagnostic value of 18F-FDG PET-CT in detecting the primary breast malignancy with other imaging modalities and to determine whether detectability of PET-CT depends on any factors such as size, differentiation, or nuclear grade of tumor. We evaluated pathologically proven 66 lesions in 61 patients (26-74 years, mean 46.9) who underwent preoperative PET-CT. Other imaging modalities were also evaluated: mammography in 58, US in 49 and MRI in 16. PET-CT images were visually evaluated and peak and mean SUV of mass were measured. For mammography and US, category 4 and 5 lesions as positive, and category 0-3 lesions as negative. For MRI, we used morphology and dynamic kinetic curve data based scoring system; sum of the scores higher than 10 as positive. Sensitivities of each modality were obtained. We analyzed PET-CT positive and negative groups in relation to size, SUV, differentiation and nuclear grade of tumors using paired t-test and Fisher's exact test. 65 among 66 were malignant lesions: invasive ductal carcinoma (n=56), ductal carcinoma in situ (n=3), tubular carcinoma (n=1), medullary carcinoma(n=3), mucinous carcinoma(n=1) and malignant fibrous histiocytoma (n=1). One lesion was benign lesion. Sensitivities of PET-CT, mammography, US, and MRI for detecting malignant mass were 86.2%, 80.7%, 100% and 94.1% respectively. SUV(P) and SUV(M) in PET-CT positive group (5.28{+-}3.24 and 3.56{+-}2.24) was significantly higher than that of PET CT negative group (1.96{+-}0.35 and 1.46{+-}0.44) [p<0.0001 for both]. The size of the primary mass in PET-CT positive group (2.66{+-}1.47) was significantly larger than that in PET-CT negative group (1.52{+-}0.57) (p=0.0002). The nuclear grade and tumor differentiation were not significantly different between two groups. The sensitivity of the FDG PET-CT in detecting primary breast cancer is lower than those of other imaging modalities. The detectability of the FDG PET-CT might be degraded when the tumor is small in size.

  17. Diagnostic value of FDG PET-CT for detecting primary breast malignancy: comparison with other image modalities and histopathologic correlation

    International Nuclear Information System (INIS)

    To compare the diagnostic value of 18F-FDG PET-CT in detecting the primary breast malignancy with other imaging modalities and to determine whether detectability of PET-CT depends on any factors such as size, differentiation, or nuclear grade of tumor. We evaluated pathologically proven 66 lesions in 61 patients (26-74 years, mean 46.9) who underwent preoperative PET-CT. Other imaging modalities were also evaluated: mammography in 58, US in 49 and MRI in 16. PET-CT images were visually evaluated and peak and mean SUV of mass were measured. For mammography and US, category 4 and 5 lesions as positive, and category 0-3 lesions as negative. For MRI, we used morphology and dynamic kinetic curve data based scoring system; sum of the scores higher than 10 as positive. Sensitivities of each modality were obtained. We analyzed PET-CT positive and negative groups in relation to size, SUV, differentiation and nuclear grade of tumors using paired t-test and Fisher's exact test. 65 among 66 were malignant lesions: invasive ductal carcinoma (n=56), ductal carcinoma in situ (n=3), tubular carcinoma (n=1), medullary carcinoma(n=3), mucinous carcinoma(n=1) and malignant fibrous histiocytoma (n=1). One lesion was benign lesion. Sensitivities of PET-CT, mammography, US, and MRI for detecting malignant mass were 86.2%, 80.7%, 100% and 94.1% respectively. SUV(P) and SUV(M) in PET-CT positive group (5.28卤3.24 and 3.56卤2.24) was significantly higher than that of PET CT negative group (1.96卤0.35 and 1.46卤0.44) [p<0.0001 for both]. The size of the primary mass in PET-CT positive group (2.66卤1.47) was significantly larger than that in PET-CT negative group (1.52卤0.57) (p=0.0002). The nuclear grade and tumor differentiation were not significantly different between two groups. The sensitivity of the FDG PET-CT in detecting primary breast cancer is lower than those of other imaging modalities. The detectability of the FDG PET-CT might be degraded when the tumor is small in size

  18. Composite containing coated fibrous material

    Energy Technology Data Exchange (ETDEWEB)

    Singh, R.N.; Gaddipati, A.R.

    1989-12-26

    This patent describes a process for producing a composite containing at least about 10% by volume of boron nitride coated fibrous material and having a porosity of less than about 20% by volume. It comprises: forming a slurry of infiltration-promoting material and organic binding material in a liquid medium; depositing a coating of boron nitride on fibrous material leaving no significant portion thereof exposed; depositing a silicon-wettable coating on the boron nitride-coated fibrous material leaving no significant portion of the boron nitride exposed; providing the resulting coated fibrous material substantially as a layer; casting the slurry onto the coated fibrous material in an amount sufficient to form a tape therewith; evaporating the liquid medium forming a tape; firing the tape to remove the organic binding material producing a porous body; providing an infiltrant comprised of boron and silicon containing elemental boron in solution in silicon in an amount of at least about 0.1% by weight of elemental silicon; contacting the porous body with infiltrant associated infiltrating means whereby the infiltrant is infiltrated into the porous body; heating the resulting assembly in a partial vacuum to a temperature at which the infiltrant is molten and infiltrating the molten infiltrant into the porous body to produce an infiltrated product; and cooling the product producing the composite.

  19. Composite containing coated fibrous material

    International Nuclear Information System (INIS)

    This patent describes a process for producing a composite containing at least about 10% by volume of boron nitride coated fibrous material and having a porosity of less than about 20% by volume. It comprises: forming a slurry of infiltration-promoting material and organic binding material in a liquid medium; depositing a coating of boron nitride on fibrous material leaving no significant portion thereof exposed; depositing a silicon-wettable coating on the boron nitride-coated fibrous material leaving no significant portion of the boron nitride exposed; providing the resulting coated fibrous material substantially as a layer; casting the slurry onto the coated fibrous material in an amount sufficient to form a tape therewith; evaporating the liquid medium forming a tape; firing the tape to remove the organic binding material producing a porous body; providing an infiltrant comprised of boron and silicon containing elemental boron in solution in silicon in an amount of at least about 0.1% by weight of elemental silicon; contacting the porous body with infiltrant associated infiltrating means whereby the infiltrant is infiltrated into the porous body; heating the resulting assembly in a partial vacuum to a temperature at which the infiltrant is molten and infiltrating the molten infiltrant into the porous body to produce an infiltrated product; and cooling the product producing the composite

  20. Solitary fibrous tumor of the kidney: a case report

    Directory of Open Access Journals (Sweden)

    Gustavo Soares Corr阛 Silva

    2014-08-01

    Full Text Available We describe a case report of a rare cancer affecting the kidney of 63 years of age patient who underwent imaging studies from ultrasound, computed tomography, and magnetic resonance imaging, due to complaints: left back pain and urinary obstruction. Sonographic and radiological features of the mass found suggested the diagnosis of a malignant tumor of parenchymal origin. The pathological and immunohistochemical studies of the resected anatomical specimen, however, diagnosed a rare benign variant of solitary fibrous tumor originating in the inferior pole of the left kidney.

  1. Quantification of the magnetization-transfer contrast effect: can it yield additional information in differentiation of musculoskeletal lesions particularly in separation of benign from malignant lesions; Quantifizierung des Magnetization Transfer Contrast (MTC) Effektes durch Berechnung von MT-Quotienten: Ergeben sich Zusatzinformationen fuer die Differenzierung benigner und maligner Erkrankungen des Bewegungsapparates?

    Energy Technology Data Exchange (ETDEWEB)

    Vahlensieck, M.; Traeber, F.; Schild, H. [Radiologische Universitaetsklinik Bonn (Germany); Gieseke, J. [Philips Medizinsysteme (Germany)

    1999-12-01

    Purpose: To investigate the potential information of the amount of magnetization-transfer effect in musculoskeletal lesions and to compare MT ratios from benign and malignant musculoskeletal lesions. Material and Method: 49 patients with malignant tumors (3 osteosarcoma, 3 malignant fibrous histiocytoma, 4 chondrosarcoma, 2 Ewing sarcomas) and benign lesions (8 chondroma, 2 fibrous dysplasia, 3 osteoid-osteoma, 6 ganglion cyst, 3 cyst, 3 osteomyelitis, 4 tendinitis, 3 rotator cuff tear, 5 scar tissue) were scanned using routine MRI protocols including T{sub 1}- and T{sub 2}-weighted spin echo as well as T{sub 2}*-weighted gradient echo (FFE) sequences at 1.5 Tesla (ACS II, Philips Medical). Additionally MTC images were generated by combining the FFE sequence and the off-resonance MT technique (-1500 Hz off-resonance frequency, 1770 flip angle and 50 ms pulse duration). MT ratios were calculated as SI{sub o}-SI{sub m}/SI{sub o}. Results: The MT ratio of benign lesions was 26{+-}15%, that of malignant lesions was 22{+-}6%. The difference was statistically not significant. As expected muscle showed a high MT ratio of 50{+-}8%. Scar tissue demonstrated an MT ratio of 39{+-}16% which was significantly higher than the tumor MT ratios. Conclusion: MTC (MT ratios) failed to show significant differences between benign and malignant lesions as was expected due to basic differences in cellularity, rate of mitosis and chromatin content. MTC might however gain more importance in separating scar tissue from recurrent tumor in the future. (orig.) [German] Zielsetzung: Durch die Quantifizierung des Magnetization Transfer Contrastes sollte untersucht werden, ob sich Zusatzinformationen in der Magnetresonanztomographie des Stuetz- und Bewegungsapparates ergeben. Insbesondere sollte ermittelt werden, ob gut- und boesartige Laesionen unterschiedliche MT-Quotienten aufweisen. Material und Methode: 49 Patienten mit boesartigen Tumoren (3 Osteosarkom, 4 Chondrosarkom, 3 Malignes Fibroeses Histiozytom, 2 Ewing-Sarkom) and gutartigen Erkrankungen (8 Chondrom, 2 Fibroese Dysplasie, 3 Osteoid-Osteom, 6 Ganglion, 3 Zysten, 3 Osteomyelitis, 4 Tendinitis, 3 Rotatorenmanschettenruptur, 5 Narbengewebe) wurden mit herkoemmlicher MRT sowie resonanz-frequenzferner MTC-Methode (-1500 Hz Resonanzverschiebung, 50 ms Pulslaenge, 1770 MT-Pulswinkel) bei 1,5 Tesla (ACS II, Philips Medizinsysteme) untersucht. Der MTC-Effekt wurde durch Berechnung des MT-Quotienten (MT-ratio) quantifiziert. Ergebnisse: Der MT-Quotient gutartiger Laesionen lag im Mittel gering ueber dem maligner Laesionen (26{+-}15% versus 22{+-}6%). Der Unterschied war statistisch nicht signifikant. Narbengewebe wies einen signifikant hoeheren MT-Quotienten (39{+-}16%) als Tumoren auf. Schlussfolgerung: Die Berechnung des MT-Quotienten ist nicht geeignet, um gutartige von boesartigen Erkrankungen des Stuetz- und Bewegungsapparates zu unterscheiden. Zur Differenzierung von Narbengewebe gegenueber Tumorrezidiv koennte MTC einen Stellenwert erlangen. (orig.)

  2. Fibrous Pseudotumor of the Penis 鈥 An Unusual Finding During Repair of Fractured Penis

    Directory of Open Access Journals (Sweden)

    Sunny Nalavenkata

    2014-01-01

    Full Text Available Fibrous pseudotumors of the testis and penis are a rare phenomenon, forming a spectrum of heterogeneous lesions. To the best of our knowledge, there has been only 1 previous report arising from the penis. We present a case of fibrous pseudotumor of the penis, incidentally found during the surgical repair of a fractured penis. These benign lesions have been described in the literature and are most commonly referred to as pseudotumors. They should be distinguished from potentially malignant lesions, including fibrosarcomas, squamous cell carcinoma, and polypoid urothelial carcinoma. Being aware of this pathology is important to prevent unnecessary radical surgery.

  3. Creep of fibrous composite materials

    DEFF Research Database (Denmark)

    Lilholt, Hans

    1985-01-01

    Models are presented for the creep behaviour of fibrous composite materials with aligned fibres. The models comprise both cases where the fibres remain rigid in a creeping matrix and cases where the fibres are creeping in a creeping matrix. The treatment allows for several contributions to the...... creep strength of composites. The advantage of combined analyses of several data sets is emphasized and illustrated for some experimental data. The analyses show that it is possible to derive creep equations for the (in situ) properties of the fibres. The experiments treated include model systems such...

  4. Fracture toughness in fibrous materials

    CERN Document Server

    Menezes-Sobrinho, I L

    2001-01-01

    In the present paper, a fiber bundle model in (1+1)-dimensions that simulates the rupture process of a fibrous material pulled by an uniaxial force F is analyzed. In this model the load of a broken fiber is shifted in equal portions onto the nearest unbroken fibers. The force-displacement diagram is obtained for several traction velocities v and temperatures t. Also, it is shown how the fracture toughness $K_c$ changes with the traction velocity v and with the temperature t. In this paper it is shown that the rupture process is strongly dependent on temperature t and on velocity v.

  5. Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma

    Indian Academy of Sciences (India)

    Kolla V, P Rasad; Aftab Taiyab; D Jyothi; Usha K Srinivas; Amere S Sreedhar

    2007-04-01

    Heat shock response is associated with the synthesis of heat shock proteins (Hsps) which is strictly regulated by different members of heat shock transcription factors (HSFs). We previously reported that a rat histiocytoma, BC-8 failed to synthesize Hsps when subjected to typical heat shock conditions (42掳C, 60 min). The lack of Hsp synthesis in these cells was due to a failure in HSF1 DNA binding activity. In the present study we report that BC-8 tumor cells when subjected to heat shock at higher temperature (43掳C, 60 min) or incubation for longer time at 42掳C, exhibited necrosis characteristics; however, under mild heat shock (42掳C, 30 min) conditions cells showed activation of autophagy. Mild heat shock treatment induced proteolysis of HSF1, and under similar conditions we observed an increase in HSF2 expression followed by its enhanced DNA binding activity. Inhibiting HSF1 proteolysis by reversible proteasome inhibition failed to inhibit heat shock induced autophagy. Compromising HSF2 expression but not HSF1 resulted in the inhibition of autophagy, suggesting HSF2 dependent activation of autophagy. We are reporting for the first time that HSF2 is heat inducible and functions in heat shock induced autophagic cell death in BC-8 tumor cells.

  6. Solitary fibrous tumor of the intrathoracic goiter

    Science.gov (United States)

    Vaziri, Mohammad; Molanaei, Saadat; Tamannaei, Zeinab

    2014-01-01

    Solitary Fibrous Tumors (SFTs) are rare primary pleural neoplasms which have recently been reported in extra-thoracic sites. In this report, solitary fibrous tumor arising in an intra-thoracic goiter with no evidence of cervical mass in a 74-year-old obese man who was found to have a large superior mediastinal mass with tracheal deviation on Chest X-Ray is presented. PMID:25405117

  7. Tissue Engineering with Nano-Fibrous Scaffolds

    OpenAIRE

    Smith, Laura A.; Liu, XiaoHua; Peter X Ma

    2008-01-01

    Tissue Engineering is a rapidly evolving field in terms of cell source and scaffold fabrication. As the template for three dimensional tissue growth, the scaffold should emulate the native extracellular matrix, which is nano-fibrous. Currently, there are three basic techniques capable of generating nano-fibrous scaffolding: electrospinning, molecular self-assembly, and thermally induced phase separation. These scaffolds can then be further modified by various three dimensional surface modific...

  8. Sampling Citrus Fibrous Roots and Tylenchulus semipenetrans

    OpenAIRE

    Duncan, L.W.; El-Morshedy, M. M.; McSorley, R.

    1994-01-01

    Sampling precision was investigated for Tylenchulus semipenetrans juveniles and males in soil and females from roots and for citrus fibrous root mass density. For the case of two composite samples of 15 cores each, counts of juvenile and male nematodes were estimated to be within 40% of ?, at P 1,500 nematodes/100 cm soil. A similar level of ? was estimated for measurements of fibrous root mass density, but at a precision level of 25% of ?. Densities of fema...

  9. Antibacterial Properties of Nanosilver PLLA Fibrous Membranes

    OpenAIRE

    Lin Li; Yi Li; Jiashen Li; Lei Yao; Arthur F. T. Mak; Frank Ko; Ling Qin

    2009-01-01

    Nanosilver has been studied as a valuable material for it strong antibacterial effects. In this study, we investigated the antibacterial properties of nano silver Poly-L-Lactic acid (Ag/PLLA) composite fibrous membranes. Ag/PLLA fibrous membranes were prepared with silver nanoparticles having weight ratio of silver nanoparticles to PLLA at 5% (w/w). In vitro antibacterial tests were performed using Escherichia coli (E. coli) and Staphylococcus aureus (Staph.) to determine the antibacteri...

  10. [Fibrous dysplasia of the clivus: case report].

    Science.gov (United States)

    Falavigna, Asdrubal; Borba, Luis Alencar B; Teles, Alisson Roberto

    2006-06-01

    We describe the case of a 43 year-old woman with chronic headache and diplopia. The neuroradiologic exam showed volume increase and alteration in the bone density of the clivus. She was submitted to surgery and the anatomopathologic evidenced fibrous dysplasia. Other 14 of about fibrous dysplasia involving the clivus are related in the literature. We discuss clinical aspects, image exams, histology and treatment of this rare presentation of the disease. PMID:16791381

  11. Modelling and analysing oriented fibrous structures

    Science.gov (United States)

    Rantala, M.; Lassas, M.; Sampo, J.; Takalo, J.; Timonen, J.; Siltanen, S.

    2014-03-01

    A mathematical model for fibrous structures using a direction dependent scaling law is presented. The orientation of fibrous nets (e.g. paper) is analysed with a method based on the curvelet transform. The curvelet-based orientation analysis has been tested successfully on real data from paper samples: the major directions of fibrefibre orientation can apparently be recovered. Similar results are achieved in tests on data simulated by the new model, allowing a comparison with ground truth.

  12. Modelling and analysing oriented fibrous structures

    International Nuclear Information System (INIS)

    A mathematical model for fibrous structures using a direction dependent scaling law is presented. The orientation of fibrous nets (e.g. paper) is analysed with a method based on the curvelet transform. The curvelet-based orientation analysis has been tested successfully on real data from paper samples: the major directions of fibrefibre orientation can apparently be recovered. Similar results are achieved in tests on data simulated by the new model, allowing a comparison with ground truth

  13. Congenital fibrous hamartoma of the knee

    International Nuclear Information System (INIS)

    A full-term male infant presented at birth with a hard swelling of the left knee. The lemon-sized lesion was fixed to the underlying knee muscles, while the overlying skin was stretched and shiny; there was no bruit. Radiography, sonography and MRI suggested a soft-tissue tumour. After surgical excision, histology showed the presence of fibrous and mesenchymal tissue, with mature adipose tissue. Fibrous hamartoma of infancy was diagnosed. Among soft-tissue tumours, fibrous hamartoma of infancy is a rare and benign lesion, occurring in the first 2 years of life. The tumour mainly affects the trunk, axilla, and upper extremities. This infant had unique involvement of the knee. The treatment of choice is local excision. (orig.)

  14. Fibrous Dysplasia Characterization Using Lacunarity Analysis.

    Science.gov (United States)

    Cordeiro, Mirna S; Backes, Andr茅 R; J煤nior, Ant么nio F Durighetto; Gon莽alves, Elmar H G; de Oliveira, Jefferson X

    2016-02-01

    Fibrous dysplasia (FD) is a developmental anomaly in which the normal medullary space of the affected bone is replaced by fibro-osseous tissue. This condition is typically encountered in adolescents and young adults. It affects the maxillofacial region and it can often cause severe deformity and asymmetry. Therefore, accurate diagnosis is critical to determine the appropriate treatment of each case. In this sense, computed tomography (CT) is a relevant resource among the imaging techniques for correct diagnosis of this condition. Thus, in this paper, we propose to analyze fibrous dysplasia through its texture pattern. To accomplish this task, we propose to use lacunarity analysis, a multiscale method for describing patterns of spatial dispersion. Results indicated lower lacunarity values for fibrous dysplasia in comparison to normal bone samples, an indication that their texture images are more homogeneous, and a high separability between the classes when using principal component analysis (PCA) and decision trees for statistical analysis. PMID:26307180

  15. A SOLITARY FIBROUS TUMOR IN THE EXTERNAL AUDITORY CANAL - A RARE CASE REPORT

    Directory of Open Access Journals (Sweden)

    Rabindra Kumar

    2014-01-01

    Full Text Available This paper reports a rare case of solitary fibrous tumor (SFT arising independently from the external auditory canal. A 16 - year - old female patient presented with mass in left external auditory canal and aural fullness. Physical examination revealed a large papillomatous mass coming out from left external auditory canal. The patient underwent surgical removal of tumor . A light microscopic study showed a spindle - cell proliferation with a collagenous stroma and a staghorn - like vascular pattern. The tumor cells were immune histochemically positive for vimentin. One week after resection aural fulln ess had resolved. Solitary fibrous tumor is a rar e mesenchymal tumor which originates in the pleura or at virtually any site in the soft tissue.It has been observed that 78% to 88% of SFT抯 are benign and 12% to 22% are malignant.En - bloc resection remains the cornerstone of therapy. Although , several cases of extra pleural SFT have been reported , only one case of external auditory canal SFT has been reported so far. Excision of SFT of the external auditory canal is advisable , especially in the presence of symptoms , and should be preceded by confirmation of non - malignancy by biopsy , if possible. Solitary fibrous tumor ; Mesenchymal tumor ; External auditory meatus; Immunohistochemistry; vimentin.

  16. Primary solitary fibrous tumor of the retroperitoneum

    Directory of Open Access Journals (Sweden)

    Hind Charhi

    2011-12-01

    Full Text Available Solitary fibrous tumor is an uncommon neoplasm affecting adults and typically located in the pleura and can also occur in a large number of other extra thoracic sites. We present the case of a solitary fibrous tumor (SFT of the retroperitoneum and describe their histopathological and immunohistochemical features. The identification of SFT in the retroperitoneum is of importance because its clinico-pathological behaviour is still unclear. The pathologist plays a fundamental role in establishing both the positive and differential diagnosis.

  17. On the filtration of fibrous aerosols

    International Nuclear Information System (INIS)

    Basic peculiarities occuring during the filtration of fibrous aerosols are discussed. Using aerosols of very fine asbestos fibers, filtration efficiencies of some analytical filters -Nuclepore and Millipore filters - were investigated. The collection efficiences were measured by means of electron microscopy and radiolabeled asbestos fibers. The collection efficiencies, which depended on the pore sizes of the filters and on the fiber form of the used aerosol, lay in the range of about 40-99.9%. A special problem discussed is the orientation of fibrous particles in the vicinity of filter pore entrances. (author)

  18. Malignant hyperthermia

    Science.gov (United States)

    Repeated or untreated episodes can cause kidney failure. Untreated episodes can be fatal. ... such as cocaine, amphetamine (speed), and ecstasy. These drugs may cause problems similar to malignant hyperthermia in people who ...

  19. Malignant teratoma

    Science.gov (United States)

    ... is often located in the front chest area (mediastinum). Most malignant teratomas can spread throughout the body, ... Diseases of the diaphragm, chest wall, pleura, and mediastinum. In: Goldman L, Schafer AI, eds. Goldman's Cecil ...

  20. Malignant hypertension

    Science.gov (United States)

    ... Collagen vascular disorders (such as systemic lupus erythematosus, systemic sclerosis, and periarteritis nodosa) Kidney problems Pregnancy-induced high blood pressure ( toxemia ) You are at high risk for malignant hypertension if you have had: Kidney ...

  1. Consolidation and densification methods for fibrous monolith processing

    Science.gov (United States)

    Sutaria, Manish P.; Rigali, Mark J.; Cipriani, Ronald A.; Artz, Gregory J.; Mulligan, Anthony C.

    2006-06-20

    Methods for consolidation and densification of fibrous monolith composite structures are provided. Consolidation and densification of two- and three-dimensional fibrous monolith components having complex geometries can be achieved by pressureless sintering. The fibrous monolith composites are formed from filaments having at least a first material composition generally surrounded by a second material composition. The composites are sintered at a pressure of no more than about 30 psi to provide consolidated and densified fibrous monolith composites.

  2. Development of oxide fibrous monolith systems.

    Energy Technology Data Exchange (ETDEWEB)

    Goretta, K. C.

    1999-03-02

    Fibrous monolithic ceramics generally have a cellular structure that consists of a strong cell surrounded by a weaker boundary phase [1-5]. Fibrous monoliths (FMs) are produced from powders by conventional ceramic fabrication techniques, such as extrusion [1,2]. When properly engineered, they exhibit fail gracefully [3-5]. Several compositions of ceramics and cermets have been processed successfully in fibrous monolithic form [4]. The most thoroughly investigated fibrous monolith consists of Si{sub 3}N{sub 4} cells and a BN cell-boundary phase [3-5]. Through appropriate selection of initial powders and extrusion and hot-pressing parameters, very tough final products have been produced. The resultant high toughness is due primarily to delamination during fracture along textured platelike BN grains. The primary objectives of our program are to develop: (1) Oxide-based FMs, including new systems with improved properties; (2) FMs that can be pressureless sintered rather than hot-pressed; (3) Techniques for continuous extrusion of FM filaments, including solid freeform fabrication (SFF) for net-shape fabrication of FMs; (4) Predictive micromechanical models for FM design and performance; and (5) Ties with industrial producers and users of FMs.

  3. Temporosphenoidal Fibrous Dysplasia: A Case Report

    Directory of Open Access Journals (Sweden)

    Mustafa ERDAL

    2006-12-01

    Full Text Available Fibrous dysplasia (FD is a localized disorder of bone that may lead to bony distortional expansions. We report a case of FD of the temporosphenoidal bone. In this case, we took out subtotally the part of the temporal bone extending to the skull base with speed-drilling.

  4. Unilateral Fibrous ankylosis of the Temporomandibular Joint

    Directory of Open Access Journals (Sweden)

    Kamala R

    2012-04-01

    Full Text Available Ankylosis of the Temporomandibular joint (TMJ is a chronic mandibular hypomobility and is one of the commonest TMJ disorders encountered in the patients.The present case is about the history of fourteen years old fibrous ankylosis of the condyle of the TMJ with its clinical and the radiological features and the treatment modalities.

  5. Steam Reformer With Fibrous Catalytic Combustor

    Science.gov (United States)

    Voecks, Gerald E.

    1987-01-01

    Proposed steam-reforming reactor derives heat from internal combustion on fibrous catalyst. Supplies of fuel and air to combustor controlled to meet demand for heat for steam-reforming reaction. Enables use of less expensive reactor-tube material by limiting temperature to value safe for material yet not so low as to reduce reactor efficiency.

  6. Damage mechanisms of random fibrous networks

    Science.gov (United States)

    Sozumert, E.; Farukh, F.; Demirci, E.; Acar, M.; Pourdeyhimi, B.; Silberschmidt, V. V.

    2015-07-01

    Fibrous networks are ubiquitous: they can be found in various engineering applications as well as in biological tissues. Due to complexity of their random microstructure, anisotropic properties and large deformation, their modelling is challenging. Though, there are numerous studies in literature focusing either on numerical simulations of fibrous networks or explaining their damage mechanisms at micro or meso-scale, the respective models usually do not include actual random microstructure and failure mechanisms. The microstructure of fibrous networks, together with highly non-linear mechanical behaviourof their fibres, is a key to initiation of damage, its spatial localization and ultimate failure [1]. Numerical models available in literature are not capable of elucidating actual microstructure of the material and, hence, its influence on damage processes in fibrous networks. To emulate a real-life microstructure in a developed finite-element model, an orientation distribution function for fibresobtained from X-ray micro computed-tomography images was considered to provide actual alignment of fibres. To validate the suggested model, notched and unnotched rectangular specimens were experimentally tested. A good correlation between the experimental data and simulation results was observed. This study revealed a significant effect of a notch on damage evolution.

  7. Solitary fibrous tumor of the pleura 鈥 analysis of 18 cases

    Science.gov (United States)

    Pryt, 艁ukasz; Szlachci艅ska, Aleksandra; Walczak-Pasz, Gra偶yna; Jesionek-Kupnicka, Dorota; Kozak, J贸zef

    2015-01-01

    Introduction Solitary fibrous tumors of the pleura (SFTP) are primary tumors arising from mesenchymal cells. Immunohistochemical studies have demonstrated that the origin of these tumors is mesenchymal rather than mesothelial. The aim of this study is to present our experience with diagnosing and treating patients with SFTP. Material and methods We analyzed 18 patients treated at the Department of Thoracic Surgery of the Medical University of Lodz. The patients鈥 medical histories and the results of postoperative histopathological investigation of the tumors were analyzed. Postoperative histopathological samples were evaluated with regard to the current criteria of malignancy. Results In 17 patients, the tumors were surgically removed. Benign and small lesions (less than 3 cm in size) were removed by video-assisted thoracoscopic surgery (VATS). In 5 cases, malignant tumors were found in the postoperative material. Conclusions Solitary fibrous tumors of the pleura is a tumor with frequently asymptomatic clinical course. Treatment consists in resection which includes the adjacent structures, especially if the tumor is malignant. PMID:26702276

  8. Malignant mesothelioma

    Directory of Open Access Journals (Sweden)

    Parker Robert J

    2008-12-01

    Full Text Available Abstract Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis. The exact prevalence is unknown but it is estimated that mesotheliomas represent less than 1% of all cancers. Its incidence is increasing, with an expected peak in the next 10鈥20 years. Pleural malignant mesothelioma is the most common form of mesothelioma. Typical presenting features are those of chest pain and dyspnoea. Breathlessness due to a pleural effusion without chest pain is reported in about 30% of patients. A chest wall mass, weight loss, sweating, abdominal pain and ascites (due to peritoneal involvement are less common presentations. Mesothelioma is directly attributable to occupational asbestos exposure with a history of exposure in over 90% of cases. There is also evidence that mesothelioma may result from both para-occupational exposure and non-occupational "environmental" exposure. Idiopathic or spontaneous mesothelioma can also occur in the absence of any exposure to asbestos, with a spontaneous rate in humans of around one per million. A combination of accurate exposure history, along with examination radiology and pathology are essential to make the diagnosis. Distinguishing malignant from benign pleural disease can be challenging. The most helpful CT findings suggesting malignant pleural disease are 1 a circumferential pleural rind, 2 nodular pleural thickening, 3 pleural thickening of > 1 cm and 4 mediastinal pleural involvement. Involvement of a multidisciplinary team is recommended to ensure prompt and appropriate management, using a framework of radiotherapy, chemotherapy, surgery and symptom palliation with end of life care. Compensation issues must also be considered. Life expectancy in malignant mesothelioma is poor, with a median survival of about one year following diagnosis.

  9. Malignant Catatonia

    Directory of Open Access Journals (Sweden)

    Ayca Ozkul

    2010-12-01

    Full Text Available Catatonia is a syndrome characterized by mutism, immobility, negativism, stereotypy, mannerisms, echophenomena, perseveration and passive obedience. The underlying causes can be psychiatric or may be associated with general medical status or neurological diseases. Additionally catatonia has two subtypes as malignant and nonmalignant catatonia. Main symptoms of malignant catatonia are hyperthermia and autonomic symptoms such as tachycardia, tachypnea and hyperhidrosis. It is important to make the diagnosis as early as possible for an appropriate medical treatment. Clinicians should be aware of the fatal outcome of the disease.

  10. Electron microprobe identification of fibrous aerosols in ambient air

    International Nuclear Information System (INIS)

    Nuclepore filters were used for sampling fibrous particles in ambient air. The fiber counting and fiber size measurements were done by means of SEM-methods. The number of fibers, distribution of fiber lengths, and diameters were plotted. The specific identification of asbestos fibers was made by electron microprobe analysis. Certain elements such as Si, Fe, Mg, Al, Mn, Ca, and Na as well as ratios such as Fe/Si and Mg/Si proved to be approximative identification factors for ambient asbestos. Not only asbestos and glass, also many other inorganic fibrous particles were found in the urban atmosphere as well as in the atmosphere of remote regions. Fibrous gypsum, fibrous ammonium sulfates, fibrous silicates, fibrous mica, and quartz were identified among these particles. Even in remote ambient air, relatively high concentrations of fibrous particles (103-104 m-3) could be measured, although the concentration of asbestos fibers were usually smaller than 102 m-3

  11. Solitary Fibrous Tumor of the Lower Leg: A Rare and Difficult Diagnosis

    OpenAIRE

    D鈥橝rpa, Salvatore; Rossi, Matteo; Montesano, Luigi; Florena, Ada Maria; Moschella, Francesco; Cordova, Adriana

    2015-01-01

    Summary: Solitary fibrous tumor (SFT) is a rare neoplasm that commonly originates in the pleura. Extrapleural locations are rare and for this reason sometimes difficult to diagnose. Malignant forms with local recurrence or distant metastases have been reported, also as a consequence of inappropriate treatment. In this article, we report the case of an SFT of the lower leg in a 37-year-old man. Leg SFT is a rare occurrence, and differential diagnosis may be difficult because they can mimic a v...

  12. Nonlinear mechanics of soft fibrous materials

    CERN Document Server

    Ogden, Raymond

    2015-01-01

    The book presents a state-of-the-art overview of the fundamental theories, established models and ongoing research related to the modeling of these materials. Two approaches are conventionally used to develop constitutive relations for highly deformable fibrous materials. According to the phenomenological approach, a strain energy density function can be defined in terms of strain invariants. The other approach is based on kinetic theories, which treats a fibrous material as a randomly oriented inter-tangled network of long molecular chains bridged by permanent and temporary junctions. At the micro-level, these are associated with chemical crosslinks and active entanglements, respectively. The papers include carefully crafted overviews of the fundamental formulation of the three-dimensional theory from several points of view, and address their equivalences and differences. Also included are solutions to boundary-value problems which are amenable to experimental verification. A further aspect is the elasticity...

  13. Hematologic malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Hoogstraten, B.

    1986-01-01

    The principle aim of this book is to give practical guidelines to the modern treatment of the six important hematologic malignancies. Topics considered include the treatment of the chronic leukemias; acute leukemia in adults; the myeloproliferative disorders: polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis/agnogenic myeloid metaplasia; Hodgkin's Disease; non-Hodgkin's lymphoma; and Multiple Myeloma.

  14. Oriented fibrous structures for concrete reinforcement

    OpenAIRE

    Fangueiro, Ra鷏, ed. lit.; Marques, P.; Pereira, Cristiana Gonilho; Ara鷍o, M醨io Duarte de

    2010-01-01

    This paper reports on the work that is being undertaken at the University of Minho concerning the development of directionally oriented fibrous structures (DOFS) to be used as a concrete reinforcement material. Several glass fibre wovenlike DOFS were produced varying two parameters: roving linear density (tex) and reinforcement structural density (rovings/cm). Self-compacting concrete slabs were reinforced by DOFS structures and their bending behaviour was evaluated. The results were compared...

  15. High surface area fibrous silica nanoparticles

    KAUST Repository

    Polshettiwar, Vivek

    2014-11-11

    Disclosed are high surface area nanoparticles that have a fibrous morphology. The nanoparticles have a plurality of fibers, wherein each fiber is in contact with one other fiber and each fiber has a length of between about 1 nm and about 5000 nm. Also disclosed are applications of the nanoparticles of the present invention, and methods of fabrication of the nanoparticles of the present invention.

  16. Aerosol filtration with metallic fibrous filters

    International Nuclear Information System (INIS)

    The filtration efficiency of stainless steel fibrous filters (BEKIPOR porous mats and sintered webs) is determined using submicronic monodisperse polystyrene aerosols. Lasers spectrometers are used for the aerosol measurements. The parameters varied are the fiber diameter, the number of layers, the aerosol diameter and the superficial velocity. Two selected types of filters are tested with polydisperse methylene blue aerosols to determine the effect of bed loading on the filter performance and to test washing techniques for the regeneration of the filter

  17. Testicular fibrous hamartoma: A case report

    Directory of Open Access Journals (Sweden)

    Asuman Kilitci

    2015-09-01

    Full Text Available Fibrous hamartoma (FH of childhood is uncommon benign tumor. They are generally seen in the head and neck region, gastrointestinal system and lung. As in the case we report, they may also occur in other unusual sites such as groin and testis. The clinical presentation is almost always a mass or swelling. We hereby report a case with FH in atrophic testis which is unusual location and clinical presentation.

  18. Bifrontal solitary fibrous tumor of the meninges

    OpenAIRE

    Benoit, Michael; Janzer, Robert-Charles; Regli, Luca

    2010-01-01

    Background: We report the case of a bifrontal solitary fibrous tumor (SFT) arising from the meninges. The points of interest in this case report are the particular imaging appearance, the immunohistochemical findings and the surgical features. Case Description: A 53-year-old Caucasian male presented with a 1-year history of behavioral changes, attention disorders and anterograde memory disorders. Magnetic resonance imaging revealed a bifrontal heterogeneous lesion attached to the anterior fal...

  19. Toxicity and Carcinogenicity Mechanisms of Fibrous Antigorite

    Directory of Open Access Journals (Sweden)

    Michael Balazy

    2007-03-01

    Full Text Available We studied the effects of fibrous antigorite on mesothelial MeT-5A and monocyte-macrophage J774 cell lines to further understand cellular mechanisms induced by asbestos fibers leading to lung damage and cancer. Antigorite is a mineral with asbestiform properties, which tends to associate with chrysotile or tremolite, and frequently occurs as the predominant mineral in the veins of several serpentinite rocks found abundantly in the Western Alps. Particles containing antigorite are more abundant in the breathing air of this region than those typically found in urban ambient air. Exposure of MeT-5A and J774 cells to fibrous antigorite at concentrations of 5-100 脙沤脗录g/ml for 72 hr induced dose-dependent cytotoxicity. Antigorite also stimulated the ROS production, induced the generation of nitrite and PGE2. MeT-5A cells were more sensitive to antigorite than J774 cells. The results of this study revealed that the fibrous antigorite stimulates cyclooxygenase and formation of hydroxyl and nitric oxide radicals. These changes represent early cellular responses to antigorite fibers, which lead to a host of pathological and neoplastic conditions because free radicals and PGE2 play important roles as mediators of tumor pathogenesis. Understanding the mechanisms of the cellular responses to antigorite and other asbestos particles should be helpful in designing rational prevention and treatment approaches.

  20. Monostotic fibrous dysplasia of the lumbar spine.

    Science.gov (United States)

    Avimadje, A M; Goupille, P; Zerkak, D; Begnard, G; Brunais-Besse, J; Valat, J P

    2000-01-01

    Monostotic fibrous dysplasia is exceedingly rare. We report a case in a 61-year-old woman with a history of recurrent low back pain and sciatica since 35 years of age. While walking, she suddenly experienced pain in her right thigh. The pain spread gradually to the buttock and calf on the same side, becoming increasingly severe. The time pattern was mechanical, with exacerbation during straining. Paresthesia developed over the dorsal aspect of the right foot. Nonsteroidal antiinflammatory drugs were ineffective. Radiographs of the spine showed an expansile and heterogeneous lesion in the body of L2. Hyperactivity of L3 and L4 was seen on the bone scan. Computed tomography demonstrated heterogeneity of L2, L3, and L4, as well as hypertrophy of the neural arch of L3 and of the right posterior lamina and spinous process of L4. Alterations in L2, L3, and L4 were noted on the magnetic resonance imaging study, which showed no evidence of epidural involvement. Laboratory tests were normal. A surgical biopsy of L3 established the diagnosis of fibrous dysplasia. Since the seminal description of fibrous dysplasia in 1891, only 21 cases of monostotic spinal involvement have been published. The spinal lesions can remain clinically silent or cause spinal pain with or without neurological symptoms. Radiographic findings are variable (heterogeneity, osteolysis, expansion without cortical violation or soft tissue involvement). Calcium and phosphate levels are normal. The diagnosis depends on examination of a vertebral biopsy specimen. PMID:10773971

  1. A Case of Extensive polyostotic fibrous dysplasia

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Do [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Hwang, Eui Hwan; Lee, Sang Rae [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Kyunghee University, Seoul (Korea, Republic of)

    2000-06-15

    Fibrous dysplasia is a benign disorder of bone consisting of intramedullary proliferation of fibrous tissue and irregularly distributed, poorly developed bone. The disease manifests itself in the monostotic form in which only one bone is involved and the polyostotic form in which multiple bones at different sites are affected. We reported a extensive case of polyostotic fibrous dysplasia with involvement of craniofacial bones, mandible, ribs, extremities. A 18-year-old man showed remarkable right facial swelling who had been treated on right femur 3 years ago with a bone graft for pathologic fracture and he recognized facial swelling 5 years ago. Extraoral radiograms and computed tomogram showed diffuse sclerosis with a ground glass appearance of the most calvarial bones, facial bones. The right mandibular lesion showed very expansible lesion with mottled appearance. Bone scans showed multifocal increased uptakes in craniofacial bones, right mandible, bilaterally in ribs, humerus, femur, tibia and characteristic various deformity of right femur (shepherd's crook deformity). This case showed exceptionally bilateral, extensive nature of bone lesion and didn't show any features of skin pigmentation and endocrine disturbances.

  2. Fibrous Hamartoma of Infancy, Report of Two Cases

    Directory of Open Access Journals (Sweden)

    Ahmad Bazrafshan

    2008-05-01

    Full Text Available Objective: Fibrous hamartoma of infancy (FHI is a rare, benign soft tissue tumor that typically occurs within the first two years of life. It has a specific histologic appearance comprising of three different mesenchymal tissues with variable proportions in an organoid fashion. The clinical course is typically benign with excellent prognosis. We report two cases of this rare lesion and review its cilinicopathologic characteristics. Case(s Presentation: The first case was a 15-month-old girl who had a subcutaneous mass in the right axillary region and the other one was an 18-month-old boy with a mass on the medial surface of his right ankle. The masses were successfully excised. After 6 and 30 months follow up no recurrence occurred. Conclusion: Although the clinical and imaging findings of FHI are quite similar to those of malignant soft tissue tumor, histologic characteristics of this tumor will guide to the definite diagnosis that will prevent aggressive and mutilating procedures.

  3. Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Haris S Vasiliadis

    2013-01-01

    Full Text Available We report a case of a 32 year-old male, admitted for a lytic lesion of the distal femur. One month after the first X-ray, clinical and imaging deterioration was evident. Open biopsy revealed fibrous dysplasia. Three months later, the lytic lesion had spread to the whole distal third of the femur reaching the articular cartilage. The malignant clinical and imaging features necessitated excision of the lesion and reconstruction with a custom-made total knee arthroplasty. Intra-operatively, no obvious soft tissue infiltration was evident. Nevertheless, an excision of the distal 15.5 cm of the femur including 3.0 cm of the surrounding muscles was finally performed. The histological examination of the excised specimen revealed central low-grade osteosarcoma. Based on the morphological features of the excised tumor, allied to the clinical findings, the diagnosis of low-grade central osteosarcoma was finally made although characters of a fibrous dysplasia were apparent. Central low-grade osteosarcoma is a rare, well-differentiated sub-type of osteosarcoma, with clinical, imaging, and histological features similar to benign tumours. Thus, initial misdiagnosis is usual with the condition commonly mistaken for fibrous dysplasia. Central low-grade osteosarcoma is usually treated with surgery alone, with rare cases of distal metastases. However, regional recurrence is quite frequent after close margin excision.

  4. Integrally calcified solitary fibrous tumor in the retroperitoneum: a case report and review of the literature.

    Science.gov (United States)

    Maki, Takehiro; Fujino, Syotaro; Misu, Kenjiro; Kaneko, Hiroyuki; Inomata, Hitoshi; Omi, Makoto; Tateno, Masatoshi; Nihei, Kazuyoshi

    2016-12-01

    Solitary fibrous tumor (SFT) is a rare stromal neoplasm and usually occurs in the thoracic cavity. We here report a case of retroperitoneal SFT with prominent calcification. A 64-year-old man presented with an incidentally detected retroperitoneal mass in the right upper abdomen. Imaging tests indicated an integrally calcified mass. The lesion was observed for 2聽years and laparoscopically resected according to the patient's wish. Microscopically, the mass was mostly occupied by calcification and proliferous spindle cells were scattered with positive CD34 expression. We diagnosed morphologically benign SFT and the patient remained disease-free 1聽year after the excision. There has been no report of such integrally calcified SFT. Retroperitoneal SFT is difficult to make a preoperative diagnosis, and careful follow-up after the excision is recommended because morphological malignancy does not always correspond to clinical malignancy. PMID:26943690

  5. Calcifying fibrous pseudotumor of mediastinum--a case report.

    OpenAIRE

    Jeong, H. S.; Lee, G K; Sung, R.; Ahn, J H; Song, H. G.

    1997-01-01

    This report presents a case of calcifying fibrous pseudotumor arising in the posterior mediastinum of a 54-year-old woman. The histopathologic features of this case were identical to that of calcifying fibrous pseudotumor first designated in 1993. It is a distinctive benign fibrous lesion characterized by the presence of characteristics psammomatous or dystrophic calcification, abundant hyalinized collagen and lymphoplasmacytic cell infiltrate. Immunohistochemically most of the scattered fibr...

  6. Design of fibrous structures for civil engineering applications

    OpenAIRE

    Marques, Paula Cristina Martins Pina

    2009-01-01

    As a synergy of fibre and fibrous structures technology developments, nowadays it is possible to produce advanced fibrous materials for many non-conventional applications. The use of fibrous materials as reinforcement materials of cementitious matrices is one of its many applications that have gain new developments over the last years. Due to its inherent low tensile strength, concrete requires reinforcement in applications where significant tensile stresses will be realized in...

  7. Fibrous composites comprising carbon nanotubes and silica

    Science.gov (United States)

    Peng, Huisheng; Zhu, Yuntian Theodore; Peterson, Dean E.; Jia, Quanxi

    2011-10-11

    Fibrous composite comprising a plurality of carbon nanotubes; and a silica-containing moiety having one of the structures: (SiO).sub.3Si--(CH.sub.2).sub.n--NR.sub.1R.sub.2) or (SiO).sub.3Si--(CH.sub.2).sub.n--NCO; where n is from 1 to 6, and R.sub.1 and R.sub.2 are each independently H, CH.sub.3, or C.sub.2H.sub.5.

  8. Combination of laser treatment and intraluminal radiotherapy for malignant dysphagia

    International Nuclear Information System (INIS)

    Laser treatment for malignant dysphagia is limited by recurrent intraluminal turmour requiring repeated treatment at four to eight week intervals. To reduce the need for follow up treatment and to improve survival patients successfully palliated by laser were treated with intraluminal radio-therapy. The combination of laser treatment with intraluminal radiotherapy provides good palliation and may reduce the need for repeated endoscopic treatment. Fibrous stricture formation is a common complication. (Author)

  9. Marfan syndrome with multiseptate pneumothorax and mandibular fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Kate A

    2009-01-01

    Full Text Available We describe a rare case of pneumothorax due to Marfan syndrome associated with fibrous dysplasia of the mandible. Marfan syndrome and fibrous dysplasia were possibly due to a common etiological factor. The association between the two and other tumors described in literature related to Marfan syndrome is discussed.

  10. Fibrous microcapsules and methods of assembly and use thereof

    Energy Technology Data Exchange (ETDEWEB)

    Stupp, Samuel; Rozkiewicz, Dorota

    2015-01-27

    The present invention relates to assembly of peptide amphiphiles and biopolymers into fibrous microcapsules, and uses thereof. In particular, the present invention provides devices, compositions, and methods for interfacial self-assembly of peptide amphiphiles and biopolyments into fibrous microcapsules, and uses thereof.

  11. Chapter 03 Fibrous Annulus-Papillary Tip-LV Relationship

    OpenAIRE

    Ingels, Jr, Neil B; Karlsson, Matts

    2016-01-01

    A fibrous collagen wedge, pointing toward the left ventricle, separates the mitral valve and left atrium from the aortic valve. The portion of this wedge between the mitral and aortic valves is known as the aortic mitral curtain or the intervalvular fibrous curtain.

  12. Electrospun nanocomposite fibrous polymer electrolyte for secondary lithium battery applications

    International Nuclear Information System (INIS)

    Hybrid nanocomposite [poly(vinylidene fluoride -co- hexafluoropropylene) (PVdF-co-HFP)/magnesium aluminate (MgAl2O4)] fibrous polymer membranes were prepared by electrospinning method. The prepared pure and nanocomposite fibrous polymer electrolyte membranes were soaked into the liquid electrolyte 1M LiPF6 in EC: DEC (1:1,v/v). XRD and SEM are used to study the structural and morphological studies of nanocomposite electrospun fibrous polymer membranes. The nanocomposite fibrous polymer electrolyte membrane with 5 wt.% of MgAl2O4 exhibits high ionic conductivity of 2.80 脳 10鈭3 S/cm at room temperature. The charge-discharge capacity of Li/LiCoO2 coin cells composed of the newly prepared nanocomposite [(16 wt.%) PVdF-co-HFP+(5 wt.%) MgAl2O4] fibrous polymer electrolyte membrane was also studied and compared with commercial Celgard separator

  13. Electrospun nanocomposite fibrous polymer electrolyte for secondary lithium battery applications

    Science.gov (United States)

    Padmaraj, O.; Rao, B. Nageswara; Jena, Paramananda; Venkateswarlu, M.; Satyanarayana, N.

    2014-04-01

    Hybrid nanocomposite [poly(vinylidene fluoride -co- hexafluoropropylene) (PVdF-co-HFP)/magnesium aluminate (MgAl2O4)] fibrous polymer membranes were prepared by electrospinning method. The prepared pure and nanocomposite fibrous polymer electrolyte membranes were soaked into the liquid electrolyte 1M LiPF6 in EC: DEC (1:1,v/v). XRD and SEM are used to study the structural and morphological studies of nanocomposite electrospun fibrous polymer membranes. The nanocomposite fibrous polymer electrolyte membrane with 5 wt.% of MgAl2O4 exhibits high ionic conductivity of 2.80 脳 10-3 S/cm at room temperature. The charge-discharge capacity of Li/LiCoO2 coin cells composed of the newly prepared nanocomposite [(16 wt.%) PVdF-co-HFP+(5 wt.%) MgAl2O4] fibrous polymer electrolyte membrane was also studied and compared with commercial Celgard separator.

  14. Malignant thymoma.

    Science.gov (United States)

    Wang, L S; Huang, M H; Lin, T S; Huang, B S; Chien, K Y

    1992-07-15

    Sixty-one patients underwent operations for malignant thymomas between 1961 and 1989. Twenty-three patients had associated myasthenia gravis (MG), an incidence of 37.7%. Upon being admitted to the hospital, the patients' most common symptoms included chest pain, MG, cough, and dyspnea. Only 7 of 61 (11.5%) patients had no symptom. Tumor staging of 58 patients with invasive thymomas was performed according to Masaoka classification. The patients were classified as follows: Stage II disease, 5; Stage III, 41; Stage IVa, 8; and Stage IVb, 4. In addition, thymic carcinoma was present in three patients. The series had a resection rate of 55.7%. The incidence of operative complications was 16.3%. Only one patient died of myocardial infarction; the incidence of operative mortality was 1.6%. The patients with MG had a higher rate of resection (69.6%) and a higher incidence of complete thymectomy (14 of 23 patients; 60.9%). Mixed lymphoepithelial tumors and epithelial cell predominant tumors were the most frequent histologic patterns (45.9% and 34.4%, respectively). Fifty-two patients had postoperative radiation therapy, and 10 patients had chemotherapy. The overall cumulative survival rates in the series were 59% and 34% at 5 and 10 years, respectively. The results demonstrated that the factors affecting the prognosis may include resectability, postoperative irradiation or chemotherapy, MG, and tumor staging. The influence of histologic variation on survival rates could not be clearly defined in the series. Surgical resection, particularly complete thymectomy, followed by irradiation is the primary option of therapeutic management for malignant thymoma. PMID:1617594

  15. Epithelioid malignant mesothelioma of tunica vaginalis with deciduoid features: An unusual malignancy clinically masquerading an inguinal hernia

    Directory of Open Access Journals (Sweden)

    Sharique Ahmed

    2012-01-01

    Full Text Available Paratesticular/scrotal and inguinal canal mass lesions in elderly patients may pose a diagnostic challenge to both the surgeon as well as the pathologist. In most cases, these represent hernial sacs with their contents, and true neoplasms like lipomas, rhabdomyosarcomas, and fibrous pseudotumors are infrequent. Malignant mesotheliomas arising from the tunica layers are rare cause of inguinal and paratesticular tumors. Herein, we report a case of an elderly patient who presented with an inguinal hernia which pathologically had features of deciduoid malignant mesothelioma.

  16. [A case of retroperitoneal solitary fibrous tumor].

    Science.gov (United States)

    Tadokoro, Akira; Kawaguchi, Makoto; Koike, Hiroshi

    2010-06-01

    A 96-year-old female visited our hospital with a complaint of right flank pain. She was under treatment for diabetes mellitus, hypertension and moderate renal dysfunction in the department of internal medicine. Computer tomographic (CT) scan showed a mass 12 cm in diameter compressing the right kidney and inferior vena cava. We diagnosed the right renal cyst. Eight weeks later, CT scan revealed a gradual increase of the mass. We punctured the tumor in order to reduce her complaint and investigate the rumor. Because contrast material could not be infused into the mass, needle biopsy was performed. Pathological examination revealed hypercellularity of spindle cells, that showed positive for CD34, vimentin, desmin and Mic-2, and negative for S100, alphaSMA, c-kit, AE1/3, p53 and bcl-2. The tumor was finally diagnosed as solitary fibrous tumor. PMID:20610922

  17. Symptomatic fibrous lunato-triquetral coalition

    Energy Technology Data Exchange (ETDEWEB)

    Staebler, A.; Glaser, C.; Reiser, M. [Department of Diagnostic Radiology, Ludwig Maximilians University of Munich (Germany); Resnick, D. [Department of Radiology, Veterans Administration Medical Center, San Diego, CA (United States)

    1999-10-01

    In general, carpal coalitions are considered to be asymptomatic. Incomplete separated joints and associated changes similar to osteoarthritis and pseudoarthrosis are known as possible causes of wrist pain. We present the clinical history, plain-film, and MR imaging findings of two patients with symptomatic fibrous lunato-triquetral coalition. Conventional films disclosed a narrowed space between the lunate and triquetral bone with cysts and sclerosis similar to pseudoarthrosis. Magnetic resonance imaging showed bone marrow edema adjacent to the incomplete separated lunato-triquetral joint and Gd-DTPA enhancing fibrovascular tissue in the synovium and subarticular cysts, explaining the pain over the ulnar-sided wrist. Patients with congenital lunato-triquetral coalition may poorly tolerate stress loading or trauma, resulting in a symptomatic state similar to degenerative arthritis or pseudoarthrosis, which is demonstrated by enhanced MR imaging. (orig.) With 2 figs., 23 refs.

  18. A solitary fibrous tumor of the kidney

    Directory of Open Access Journals (Sweden)

    Anuruddha M Abeygunasekera

    2015-01-01

    Full Text Available A solitary fibrous tumor (SFT is an uncommon spindle cell neoplasm that usually occurs in the pleura, but may occur in extrapleural sites. Its occurrence in the kidney is rare. We report a SFT, clinically thought to be a renal cell carcinoma arising in the kidney of a 68-year-old female. The tumor was well-circumscribed and composed of a mixture of spindle cells and dense collagenous bands. Immunohistochemical studies revealed reactivity for CD34, CD99, and Bcl-2 protein, with no staining for keratin or muscle markers, confirming the diagnosis. The immunohistochemical study was the key to diagnosis. Several younger members of her family had colorectal and lung cancers suggesting the possibility of a familial or genetic susceptibility.

  19. Compressibility of air in fibrous materials

    DEFF Research Database (Denmark)

    Tarnow, Viggo

    1996-01-01

    The dynamic compressibility of air in fibrous materials has been computed for two assumed configurations of fibers which are close to the geometry of real fiber materials. Models with parallel cylinders placed in a regular square lattice and placed randomly are treated. For these models the...... compressibility is computed approximately from the diameter and mean distances between cylinders. This requires calculation of the air temperature, which is calculated for cylinders in a regular lattive by the Wigner-Seitz cell approximation. In the case of random placement, the calculation is done by a summation...... over thermal waves from all fibers, and by a self-consistent procedure. Figuren of the compressibility in the frequency range 10-100 000 Hz, are given for diameter of the cylinders of 6.8 碌m, and mean distances between them from 50 to 110 碌m, which corresponds to glass wool with a density of 40 to 16...

  20. Method of manufacturing fibrous hemostatic bandages

    Science.gov (United States)

    Larsen, Gustavo; Spretz, Ruben; Velarde-Ortiz, Raffet

    2012-09-04

    A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.

  1. Cytomorphology of epithelioid sarcoma: A diagnostic enigma

    Directory of Open Access Journals (Sweden)

    Yogesh K Yadav

    2012-01-01

    Full Text Available Epithelioid sarcoma is an uncommon soft tissue malignancy with a known propensity for recurrence as well as metastasis. We report epithelioid sarcoma in 50 year old male with a recurrent ulcerative nodule over the right ankle since five months, initially misdiagnosed as malignant fibrous histiocytoma. The article aims at assessing the key cytological features of epithelioid sarcoma and their reliability in the diagnosis of the lesion. Also described are its histopathological and immunohistochemical features.

  2. [Malignant hyperthermia].

    Science.gov (United States)

    Metterlein, T; Schuster, F; Graf, B M; Anetseder, M

    2014-12-01

    Malignant hyperthermia (MH) is a rare hereditary, mostly subclinical myopathy. Trigger substances, such as volatile anesthetic agents and the depolarizing muscle relaxant succinylcholine can induce a potentially fatal metabolic increase in predisposed patients caused by a dysregulation of the myoplasmic calcium (Ca) concentration. Mutations in the dihydropyridine ryanodine receptor complex in combination with the trigger substances are responsible for an uncontrolled release of Ca from the sarcoplasmic reticulum. This leads to activation of the contractile apparatus and a massive increase in cellular energy production. Exhaustion of the cellular energy reserves ultimately results in local muscle cell destruction and subsequent cardiovascular failure. The clinical picture of MH episodes is very variable. Early symptoms are hypoxia, hypercapnia and cardiac arrhythmia whereas the body temperature rise, after which MH is named, often occurs later. Decisive for the course of MH episodes is a timely targeted therapy. Following introduction of the hydantoin derivative dantrolene, the previously high mortality of fulminant MH episodes could be reduced to well under 10?%. An MH predisposition can be detected using the invasive in vitro contracture test (IVCT) or mutation analysis. Few elaborate diagnostic procedures are in the developmental stage. PMID:25384957

  3. Malignant lymphoma

    International Nuclear Information System (INIS)

    This paper describes the background and treatment, especially focusing on radiotherapy (RT), of stage I-II malignant lymphoma (ML) occurring in head and neck. For diffuse large B-cell lymphoma, the most frequently occurring ML in Japan (about 40% of all MLs), the current standard protocol involves 3 cycles of chemotherapy (CT) like rituximab to cyclophosphamide/doxorubicin/vincristine/predonisolone (CHOP) regimen followed by RT. Authors use the dose around 30 Gy/15 fr for CR patients after CHOP and 40-50 Gy/20-25 fr for PR ones. Recurrence scarcely occurs in the RT target region. However, significance of RT is still somehow controversial in this ML and addition of CHOP is currently noted. Mucosa-associated lymphoid tissue lymphoma (8.45% of Japanese ML) occurs mainly in glands and orbit and may be related with Chlamydia infection. RT is usually conducted to the whole organ with lesion as the clinical target with fractionated 30 Gy. Nasal NK/T cell lymphoma (2.6%), possibly associated with Epstein-Barr (EB) virus, is usually resistant to CHOP. Recommended is CT after RT with the dose of 50-54 Gy and depending on the target site, advanced RT like intensity-modified one is desirable. Hodgkin lymphoma (about 5%) occurs in lymph node and is derived from B-lymphocyte. Irradiation field involves the region of the disease node or that additionally including its neighbors and doses of about 20 Gy and 30 Gy are given in child and adult patients, respectively. For follicular and other tissue type lymphomas, noted are novel therapies like rituximab-combined CT, immuno-RT with 90Y-ibritumomab and 131I-tositumomab. Recently, positron emission tomography (PET) is essential for treatment assessment of the clinical response of ML in the guideline. (R.T.)

  4. Malignant hyperthermia

    Directory of Open Access Journals (Sweden)

    Pollock Neil

    2007-04-01

    Full Text Available Abstract Malignant hyperthermia (MH is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stresses such as vigorous exercise and heat. The incidence of MH reactions ranges from 1:5,000 to 1:50,000100,000 anesthesias. However, the prevalence of the genetic abnormalities may be as great as one in 3,000 individuals. MH affects humans, certain pig breeds, dogs, horses, and probably other animals. The classic signs of MH include hyperthermia to marked degree, tachycardia, tachypnea, increased carbon dioxide production, increased oxygen consumption, acidosis, muscle rigidity, and rhabdomyolysis, all related to a hypermetabolic response. The syndrome is likely to be fatal if untreated. Early recognition of the signs of MH, specifically elevation of end-expired carbon dioxide, provides the clinical diagnostic clues. In humans the syndrome is inherited in autosomal dominant pattern, while in pigs in autosomal recessive. The pathophysiologic changes of MH are due to uncontrolled rise of myoplasmic calcium, which activates biochemical processes related to muscle activation. Due to ATP depletion, the muscle membrane integrity is compromised leading to hyperkalemia and rhabdomyolysis. In most cases, the syndrome is caused by a defect in the ryanodine receptor. Over 90 mutations have been identified in the RYR-1 gene located on chromosome 19q13.1, and at least 25 are causal for MH. Diagnostic testing relies on assessing the in vitro contracture response of biopsied muscle to halothane, caffeine, and other drugs. Elucidation of the genetic changes has led to the introduction, on a limited basis so far, of genetic testing for susceptibility to MH. As the sensitivity of genetic testing increases, molecular genetics will be used for identifying those at risk with greater frequency. Dantrolene sodium is a specific antagonist of the pathophysiologic changes of MH and should be available wherever general anesthesia is administered. Thanks to the dramatic progress in understanding the clinical manifestation and pathophysiology of the syndrome, the mortality from MH has dropped from over 80% thirty years ago to less than 5%.

  5. Torsion of omental fibrous pseudotumour mimicking acute appendicitis

    OpenAIRE

    Pennington, Thomas E.; Ozmen, John; Fenton-Lee, Douglas

    2016-01-01

    Unusual pathologies are occasionally found at laparoscopy when appendicitis is suspected. We present a case of strangulated inflammatory fibrous pseudotumour of the omentum presenting in a similar fashion to appendicitis. The infarcted omentum was excised, facilitating prompt resolution of symptoms.

  6. Ehlers-Danlos syndrome with monostotic fibrous dysplasia

    Directory of Open Access Journals (Sweden)

    Rao A

    1979-01-01

    Full Text Available An unusual case of Ehlers-Danlos syndrome with monostotic fibrous dysplasia of the humorus is presented. The other orthopae-dic manifestations, its complications and associated features are re-viewed and summarised.

  7. Impregnated Fibrous Materials. Report of a Study Group on Impregnated Fibrous Materials

    International Nuclear Information System (INIS)

    There has recently been renewed interest in the use of radiation from radioisotopes or particle accelerators to initiate and sustain chemical reactions. Particular attention is being paid to the production of wood-plastic composites, a process which is now a commercial reality with radiation competing against chemical methods to enhance the properties of wood. It has been reported that water repellancy, hardness, weathering, insect and chemical resistance, compressive, bending and shear strength can be significantly improved by the process, but so far there has been a limited commercial outlet for the product. Papers on this subject were presented at the International Atomic Energy Agency's Symposium on Industrial Uses of Large Radiation Sources, Salzburg, May 1963, and since then the Agency has been aware of the interest of developing countries in conducting research on wood and other fibrous materials as a means of further exploiting natural resources. It was felt that some attempt should be made to co-ordinate, on a regional basis, the work being done in this field and at the same time review the world status, including the associated technology in such areas as monomer-polymer chemistry and impregnation techniques where they are directly related to this work. Because of the wide range of fibrous materials being studied there, Asia and the Far East was chosen as the most representative area and 39 participants from 13 countries, and from international organizations, met in Bangkok from 20 to 24 November 1967 to assess the potential of impregnated fibrous materials. This report is a record of the meeting and is based not only on work performed both inside and outside the region but also on details of the resources and industries in the area

  8. Ultrasonographic features of fibrous hamartoma of infancy

    International Nuclear Information System (INIS)

    To review imaging features of fibrous hamartoma of infancy (FHI), focusing on ultrasonography (US) findings. We retrospectively reviewed pediatric patients who were diagnosed with pathologically confirmed FHI in two children's hospitals from 2004 to 2013. Imaging features of US, Doppler US, and magnetic resonance imaging (MRI) were evaluated. Thirteen pediatric patients (M:F = 7:6; age 5-22 months, mean 11.3 months) were included. Mean lesion size was 3.2 cm (range, 0.7-8.0 cm). The tumors were located in the back (n = 4), scrotum (n = 2), scalp, shoulder, axilla, forearm, intergluteal cleft, inguinal area, and thigh. US was performed in 11 patients. With the exception of two scrotal masses, all masses were located in the dermal and subcutaneous layer. All masses demonstrated heterogeneous hyperechogenicity with a ''serpentine pattern'' of intervening hypoechoic portions in the hyperechoic mass. The margins were ill-defined (n = 9) or lobulated (n = 2). Doppler US was performed in nine patients and showed no (n = 6) or minimal (n = 3) vascularity. MRI was performed in five patients and the masses showed heterogeneous signal intensity with the presence of fat on T1- and T2-weighted images. FHI is a tumor that is typically located in the dermal and subcutaneous layer in young children less than 2 years old and presents as a heterogeneously hyperechoic mass with a ''serpentine pattern'' and ill-defined or lobulated margin on US and no remarkable vascularity on Doppler US. (orig.)

  9. Giant solitary fibrous tumour of the liver

    Directory of Open Access Journals (Sweden)

    Eggermont Alexander MM

    2006-11-01

    Full Text Available Abstract Background Solitary fibrous tumour (SFT is an uncommon mesenchymal neoplasm that most frequently affects the pleura, although it has been reported with increasing frequency in various other sites such as in the peritoneum, pericardium and in non-serosal sites such as lung parenchyma, upper respiratory tract, orbit, thyroid, parotid gland, or thymus. Liver parenchyma is rarely affected. Clinically, SFTs cause symptoms after having reached a certain size or when vital structures are involved. In recent years, SFTs are more often identified and distinguished from other tumours with a similar appearance due to the availability of characteristic immunohistochemical markers. Case presentation In this manuscript we report the case of a large tumour of the liver, which was histologically diagnosed as a SFT, and showed involvement of a single hepatic segment. Because of the patient's presentation and clinical course, it may represent a radiation-induced lesion. Conclusion When a SFT has been diagnosed, surgery is the treatment of choice. The small number of patients with a SFT of the liver and its unknown natural behaviour creates the need to a careful registration and follow-up of all identified cases

  10. Intracranial solitary fibrous tumor: Imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Clarencon, Frederic, E-mail: fredclare5@msn.com [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Bonneville, Fabrice [Department of Neuroradiology, Hopital Rangueil, Toulouse University Hospital, 31000 Toulouse (France); Rousseau, Audrey [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Galanaud, Damien [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Kujas, Michele [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Naggara, Olivier [Department of Neuroradiology, St Anne Hospital, 75014 Paris (France); Cornu, Philippe [Department of Neurosurgery, Pitie-Salpetriere Hospital (France); Chiras, Jacques [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France)

    2011-11-15

    Objective: To study the neuroimaging features of intracranial solitary fibrous tumors (ISFTs). Materials and methods: Retrospective study of neuroimaging features of 9 consecutive histopathologically proven ISFT cases. Location, size, shape, density, signal intensity and gadolinium uptake were studied at CT and MRI. Data collected from diffusion-weighted imaging (DWI) (3 patients), perfusion imaging and MR spectroscopy (2 patients), and DSA (4 patients) were also analyzed. Results: The tumors most frequently arose from the intracranial meninges (7/9), while the other lesions were intraventricular. Tumor size ranged from 2.5 to 10 cm (mean = 6.6 cm). They presented multilobular shape in 6/9 patients. Most ISFTs were heterogeneous (7/9) with areas of low T2 signal intensity that strongly enhanced after gadolinium administration (6/8). Erosion of the skull was present in about half of the cases (4/9). Components with decreased apparent diffusion coefficient were seen in 2/3 ISFTs on DWI. Spectroscopy revealed elevated peaks of choline and myo-inositol. MR perfusion showed features of hyperperfusion. Conclusion: ISFT should be considered in cases of extra-axial, supratentorial, heterogeneous, hypervascular tumor. Areas of low T2 signal intensity that strongly enhance after gadolinium injection are suggestive of this diagnosis. Restricted diffusion and elevated peak of myo-inositol may be additional valuable features.

  11. Intracranial solitary fibrous tumor: Imaging findings

    International Nuclear Information System (INIS)

    Objective: To study the neuroimaging features of intracranial solitary fibrous tumors (ISFTs). Materials and methods: Retrospective study of neuroimaging features of 9 consecutive histopathologically proven ISFT cases. Location, size, shape, density, signal intensity and gadolinium uptake were studied at CT and MRI. Data collected from diffusion-weighted imaging (DWI) (3 patients), perfusion imaging and MR spectroscopy (2 patients), and DSA (4 patients) were also analyzed. Results: The tumors most frequently arose from the intracranial meninges (7/9), while the other lesions were intraventricular. Tumor size ranged from 2.5 to 10 cm (mean = 6.6 cm). They presented multilobular shape in 6/9 patients. Most ISFTs were heterogeneous (7/9) with areas of low T2 signal intensity that strongly enhanced after gadolinium administration (6/8). Erosion of the skull was present in about half of the cases (4/9). Components with decreased apparent diffusion coefficient were seen in 2/3 ISFTs on DWI. Spectroscopy revealed elevated peaks of choline and myo-inositol. MR perfusion showed features of hyperperfusion. Conclusion: ISFT should be considered in cases of extra-axial, supratentorial, heterogeneous, hypervascular tumor. Areas of low T2 signal intensity that strongly enhance after gadolinium injection are suggestive of this diagnosis. Restricted diffusion and elevated peak of myo-inositol may be additional valuable features.

  12. Hierarchically engineered fibrous scaffolds for bone regeneration

    Science.gov (United States)

    Sachot, Nad猫ge; Casta帽o, Oscar; Mateos-Timoneda, Miguel A.; Engel, Elisabeth; Planell, Josep A.

    2013-01-01

    Surface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopographic cues, for example, influence cell proliferation and differentiation. Here, we present a novel coating protocol to produce hierarchically engineered fibrous scaffolds with tailorable surface characteristics, which mimic bone extracellular matrix. Based on the sol鈥揼el method and a succession of surface treatments, hollow electrospun polylactic acid fibres were coated with a silicon鈥揷alcium鈥損hosphate bioactive organic鈥搃norganic glass. Compared with pure polymeric fibres that showed a completely smooth surface, the coated fibres exhibited a nanostructured topography and greater roughness. They also showed improved hydrophilic properties and a Young's modulus sixfold higher than non-coated ones, while remaining fully flexible and easy to handle. Rat mesenchymal stem cells cultured on these fibres showed great cellular spreading and interactions with the material. This protocol can be transferred to other structures and glasses, allowing the fabrication of various materials with well-defined features. This novel approach represents therefore a valuable improvement in the production of artificial matrices able to direct stem cell fate through physical and chemical interactions. PMID:23985738

  13. Geotechnical Challenges in Numerical Modelling of Sarawak Fibrous Peat

    OpenAIRE

    Seneviratne Nimal

    2014-01-01

    In Sarawak, about 13% of the total land area is covered with recent peat deposits. A complex mechanism of plant growth and peat accumulation with time has led to formation of flat topped peat domes. Dome centre consists of highly fibrous ombrogeneous peat. Topogeneous peat found in the fringes of peat domes and in interior floodplains, consists of a mixture of decomposed plant matter and fine clastic sediments. Mechanical behaviour of fibrous peat is influenced by the arrangement of fibre. Th...

  14. A call to expand regulation to all carcinogenic fibrous minerals

    Science.gov (United States)

    Baumann, F.; Steele, I.; Ambrosi, J.; Carbone, M.

    2013-05-01

    The regulatory term "asbestos" groups only the six fibrous minerals that were commercially used among approximately 400. The carcinogenicity of these six regulated minerals has been largely demonstrated and is related to fiber structure, fiber length/diameter ratio, and bio-persistence. From a public perception, the generic term "asbestos" refers to the fibrous minerals that cause asbestosis, mesothelioma and other cancers. However, other non-regulated fibrous minerals are potentially as dangerous as the regulatory asbestos because they share similar physical and chemical properties, epidemiological studies have demonstrated their relationship with asbestos-related diseases, and both in vitro and in vivo experiments have established the toxicity of these minerals. For example, the non-regulated asbestiform winchite and richterite minerals that contaminated the vermiculite mined from Libby, Montana, (USA) were associated with mesothelioma, lung cancer and asbestosis observed among the area's residents and miners. Many other examples of non-regulated carcinogenic fibrous minerals include, but are not limited to, antigorite, arfvedsonite, balangeroite, carlosturanite, erionite, fluoro-edenite, hornblende, mordenite, palygorskite, and sepiolite. To propose a regulatory definition that would provide protection from all carcinogenic fibers, we have conducted an interdisciplinary literature review to compare the characteristics of "asbestos" and of non-regulated mineral fibers that relate to carcinogenicity. We specifically studied two non-regulated fibrous minerals that are associated with asbestos-related diseases: the serpentine antigorite and the zeolite erionite. Both examples underscore the problem of regulation based on commercial, rather than scientific principles: 1) the occurrence of fibrous antigorite in materials used to pave roads has been correlated with high mesothelioma rates in New Caledonia. Antigorite was also the cause of asbestosis in Poland, and in vitro and in vivo studies have shown its toxic and carcinogenic properties; 2) the carcinogenic properties of erionite have been demonstrated, and erionite has been associated with a mesothelioma epidemic in Anatolia, Turkey. Erionite is also widespread in areas of north central USA, where it is contained in gravel paving stone, and is cause for concern due to increased commercial traffic. Numerous studies have shown that non-regulated fibrous materials pose similar health hazards to regulated "asbestos". An increase in human activities in areas where these fibrous minerals are present, such as in surficial rock and soil, will result in the generation of airborne dust, exposing people to carcinogenic fibers. The current limited regulation leads people to believe that only the six mineral fibers referred to as "asbestos" are dangerous. We propose that fibrous minerals should be regulated as a single group, as they have similar deleterious effects on the human body. Regulations would be simplified and more effective if they embrace all carcinogenic fibrous minerals.

  15. Malignant lymphoma in central nervous system (CNS)

    International Nuclear Information System (INIS)

    A 71-year-old male was admitted to Kohka Public Hospital on January 4, 1980, because of frequent vomiting and recent memory loss. Two weeks before admission upper G-I series showed no abnormalities. Physical and neurological examinations revealed no abnormalities except for slightly apathetic appearance and recent memory loss. Mild pleocytosis and marked increase of protein in CSF were observed. CT scan on January 17 showed high density areas in both medial sides of temporal lobes with remarkable contrast enhancement. His memory and, consciousness disturbances gradually aggravated, accompanied by abnormal density spreading around the ventricle walls like ventriculitis. He was transfered to Kyoto University Hospital on March 17, and malignant lymphoma was diagnosed on the basis of CSF cytology. Radiation and chemotherapy alleviated the CNS involvement and he regained normal mental function. On June 16, he developed pneumonia followed by status epilepticus. Autopsy findings revealed no lymphoid cell infiltration, but fibrous tissues in both hippocampal gyri and lymphomatous cells in the liver, which could not be suspected on clinical examinations. Apparent malignant lymphoma cells were not found in lymph nodes. This case indicated peculiar evolution of malignant lymphoma from liver to CNS or vice versa. We could not decide which organ was primary. CT findings of this case was very interesting; they resembled ventriculitis, which simulate tumors such as medulloblastoma or ependymoma spreading under ependymal lining. (author)

  16. Malignant bone tumors

    International Nuclear Information System (INIS)

    Clinicoroentgenologic semiotics of malignant bone tumors as well as metastatic bone tumors are presented. Diagnosis of malignant and metastatic bone tumors should be always complex, representing a result of cooperation of a physician, roentgenologist, pathoanatomist

  17. Recurring fibrous dysplasia of anthro maxillary with cranial base invasion

    Directory of Open Access Journals (Sweden)

    Sousa, K谩tia Maria Marabuco de

    2009-09-01

    Full Text Available Introduction: Fibrous dysplasia is an osseous lesion with an unknown etiology. It is characterized by the osseous maturation insufficiency. It may affect any bone, but the affection of craniofacial bones is the most critical for otorhinolaryngology. Maxilla is the most affected facial bone and the orbitary invasion is an uncommon event. The symptoms are unspecific and for its low suspicion and uncommonness, the diagnosis is generally late. The monostotic form presents a slow growth and asymptomatic course and needs to be followed up. The polyostotic type has a progressive behavior and is associated to recurrence and complications. Objective: To present two cases of patients with fibrous dysplasia diagnosis and describe the clinical presentation, radiological findings and the treatment of this pathology. Cases Report: Two cases of fibrous dysplasia are reported, which initially presented unspecific symptomatology, but with characteristic radiologic signs. They were submitted to surgical treatment for resection of the lesions and evolved with frequent recurrences with extensive affection of the facial sinuses, one patient had cranial base invasion and frontal craniotomy was needed for tumoral excision. Final Comments: Fibrous dysplasia is an uncommon osteopathy. The tomography is the choice method for characterization of the tumoral expansion, and helps in the surgical planning. The surgical strategy is indicated for symptomatic lesions, functions alterations or anatomic disorders. This article describes two uncommon manifestations of recurrent fibrous dysplasia with an extensive affection of anthro maxillary, ethmoidal and sphenoid sinuses, in addition to orbitary and cranial base invasion.

  18. Craniofacial fibrous dysplasia - A review of current management techniques

    Directory of Open Access Journals (Sweden)

    Yadavalli Guruprasad

    2012-01-01

    Full Text Available Fibrous dysplasia is a pathologic condition of bone of unknown etiology with no apparent familial, hereditary or congenital basis. Lichtenstein first coined the term in 1938 and in 1942 he and Jaffe separated it from other fibro-osseous lesions. It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton. Its management poses significant challenges to the surgeon. Craniofacial fibrous dysplasia is 1 of 3 types of fibrous dysplasia that can affect the bones of the craniofacial complex, including the mandible and maxilla. Fibrous dysplasia is a skeletal developmental disorder of the bone-forming mesenchyme that manifests as a defect in osteoblastic differentiation and maturation. It is a lesion of unknown etiology, uncertain pathogenesis, and diverse histopathology. Fibrous dysplasia represents about 2, 5% of all bone tumors and over 7% of all benign tumours. Over the years, we have gained a better understanding of its etiology, clinical behavior, and both surgical and non-surgical treatments.

  19. Stress transfer through fibrous materials in wicking experiments

    Science.gov (United States)

    Monaenkova, Daria; Andrukh, Taras; Kornev, Konstantin

    2009-11-01

    Due to the recent progress in preparation of fibers and nanofibers with different properties, the idea of smart textiles attracts much attention. In many situations the probes and sensors are designed for bio fluid detection. The liquid penetration in fibrous materials causes their deformations including stretching, twisting, wrinkling, buckling etc. The most of researches on wicking properties of textiles are focused on determination of media permeability and ignore the specific features of fibrous materials. On the other hand the theoretical works on quantitative analysis of the deformation effects in porous materials filled with liquids are mostly focused on deformation of fully saturated samples. The fundamental understanding of the stress transfer through the fiber network is crucial for sensors development, but to the best of our knowledge, the stress analysis in the fibrous materials absorbing liquids has never been discussed in the literature. This paper sets a physical basis for analysis of absorption processes in nanotubular and nanofibrous materials. We study absorption of droplets by yarns and webs made of fibers, develop a theory which explains the stress distribution in fibrous materials and checked this theory on wicking experiments. The reported theory and experiments propose a new area of research on absorption-induced deformations of fibrous materials.

  20. Electrospun nanocomposite fibrous polymer electrolyte for secondary lithium battery applications

    Energy Technology Data Exchange (ETDEWEB)

    Padmaraj, O.; Rao, B. Nageswara; Jena, Paramananda; Satyanarayana, N., E-mail: nallanis2011@gmail.com [Department of Physics, Pondicherry University, Pondicherry-605014 (India); Venkateswarlu, M. [R and D, Amaraja batteries, Thirupathi-517501 (India)

    2014-04-24

    Hybrid nanocomposite [poly(vinylidene fluoride -co- hexafluoropropylene) (PVdF-co-HFP)/magnesium aluminate (MgAl{sub 2}O{sub 4})] fibrous polymer membranes were prepared by electrospinning method. The prepared pure and nanocomposite fibrous polymer electrolyte membranes were soaked into the liquid electrolyte 1M LiPF{sub 6} in EC: DEC (1:1,v/v). XRD and SEM are used to study the structural and morphological studies of nanocomposite electrospun fibrous polymer membranes. The nanocomposite fibrous polymer electrolyte membrane with 5 wt.% of MgAl{sub 2}O{sub 4} exhibits high ionic conductivity of 2.80 脳 10{sup 鈭3} S/cm at room temperature. The charge-discharge capacity of Li/LiCoO{sub 2} coin cells composed of the newly prepared nanocomposite [(16 wt.%) PVdF-co-HFP+(5 wt.%) MgAl{sub 2}O{sub 4}] fibrous polymer electrolyte membrane was also studied and compared with commercial Celgard separator.

  1. Fibrous minerals from Somma-Vesuvius volcanic complex

    Science.gov (United States)

    Rossi, Manuela; Nestola, Fabrizio; Ghiara, Maria R.; Capitelli, Francesco

    2016-01-01

    A survey on fibrous minerals coming from the densely populated area of Campania around the Somma-Vesuvius volcanic complex (Italy) was performed by means of a multi-methodological approach, based on morphological analyses, EMPA/WDS and SEM/EDS applications, and unit-cell determination through X-ray diffraction data. Such mineralogical investigation aims to provide suitable tools to the identification of fibrous natural phases, to improve the knowledge of both geochemical, petrogenetic and regional mineralogy of Somma-Vesuvius area, and to emphasize the presence of minerals with fibrous habit in all volcanic environments. The survey also fits well in the calls of health and environment of Horizon 2020 program of the European Commission (Climate Action, Environment, Resource Efficiency and Raw Materials).

  2. Structural characteristics, dispersion, and modification of fibrous brucite

    Science.gov (United States)

    Cao, Xi; Chuan, Xiu-yun

    2014-01-01

    Fibrous brucite has very unique structure and physical properties. Brucite fibers were exfoliated into single nanofibers by using dioctyl sodium sulfosuccinate (AOT) as a dispersant through mechanical agitation and ultrasonic dispersion; and then, the nanofibers were modified by stearic acid and (3-aminopropyl)triethoxysilane (纬-APS) compound modification agent. The nanofibers were characterized by using X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermal gravimetric analysis. It is found that AOT has good effect on the dispersion. The single fiber has a consistent morphology, and fibrous brucite is dispersed and modified without destroying the crystal structure. Infrared and thermal analysis shows that the surface modification of fibrous brucite is achieved by forming chemical bonds between the coupling agent and magnesium hydroxide.

  3. Polyostotic Fibrous Dysplasia of Cranio-Maxillofacial Area

    International Nuclear Information System (INIS)

    Fibrous dysplasia is believed to be a hamartomatous developmental lesion of unknown origin. This disease is divided into monostotic and polyostotic fibrous dysplasia. Polyostotic type can be divided into craniofacial type, Lichtenstein-Jaffe type, and McCune-Albright syndrome. In this case, a 31-year-old female presented spontaneous loss of right mandibular teeth before 5 years and has shown continuous expansion of right mandibular alveolus. Through the radiographic view, the coarse pattern of the mixed radiopaque-lucent lesion was seen on the right mandibular body, and there was diffuse pattern of the mixed radiopaque-lucent lesion with ill-defined margin in the left mandibular body. In the right calvarium, the lesion had cotton-wool appearance. Partial excision for contouring, multiple extraction, and alveoloplasty were accomplished under general anesthesia for supportive treatment. Finally we could conclude this case was polyostotic fibrous dysplasia of cranio-maxillofacial area based on the clinical, radiologic finding, and histopathologic examination.

  4. The behaviour of fibrous composite materials under nuclear radiations exposure

    International Nuclear Information System (INIS)

    The main feature of fibrous composite materials are briefly described, which are constitued by a netwoek of ceramic high performance fiber embebed in a ductile matrix material. These composite materials show such a kind of anisotropic strength that their uses has been widely spreaded in the last times. This philosophy of strengthening was used by the Nature, where are abundant examples of fibrous composites like horn, bamboo tissues, etc. In this paper are collected the published results about behaviour of reinforced dibers and fibrous composites under nuclear radiation exposure. The results show a very wide sort of fenomenae depending on many factors. Are fibers, like the boron one, which shows an inconvenient behaviour and another like graphite fibers which appears to improve its features. Is is concluded that was not achieved enough information about the behaviour of the interface under irradiation in order to build up a theory about the behaviour of the full composite under irradiation exposure. (author)

  5. Heat Transfer in High-Temperature Fibrous Insulation

    Science.gov (United States)

    Daryabeigi, Kamran

    2002-01-01

    The combined radiation/conduction heat transfer in high-porosity, high-temperature fibrous insulations was investigated experimentally and numerically. The effective thermal conductivity of fibrous insulation samples was measured over the temperature range of 300-1300 K and environmental pressure range of 1.33 x 10(exp -5)-101.32 kPa. The fibrous insulation samples tested had nominal densities of 24, 48, and 72 kilograms per cubic meter and thicknesses of 13.3, 26.6 and 39.9 millimeters. Seven samples were tested such that the applied heat flux vector was aligned with local gravity vector to eliminate natural convection as a mode of heat transfer. Two samples were tested with reverse orientation to investigate natural convection effects. It was determined that for the fibrous insulation densities and thicknesses investigated no heat transfer takes place through natural convection. A finite volume numerical model was developed to solve the governing combined radiation and conduction heat transfer equations. Various methods of modeling the gas/solid conduction interaction in fibrous insulations were investigated. The radiation heat transfer was modeled using the modified two-flux approximation assuming anisotropic scattering and gray medium. A genetic-algorithm based parameter estimation technique was utilized with this model to determine the relevant radiative properties of the fibrous insulation over the temperature range of 300-1300 K. The parameter estimation was performed by least square minimization of the difference between measured and predicted values of effective thermal conductivity at a density of 24 kilograms per cubic meters and at nominal pressures of 1.33 x 10(exp -4) and 99.98 kPa. The numerical model was validated by comparison with steady-state effective thermal conductivity measurements at other densities and pressures. The numerical model was also validated by comparison with a transient thermal test simulating reentry aerodynamic heating conditions.

  6. Magnetic resonance imaging (MRI) in the diagnosis of fibrous dysplasia

    International Nuclear Information System (INIS)

    Eleven patients with proven fibrous dysplasia of the skeleton (FD) were examined using magnetic resonance imaging (MRI). Almost constantly T1-weighted hypointense, T2-weighted hyperintense (cystic) as well as T1- and T2-weighted hypointense (fibrous) areas within the lesion could be demonstrated, the latter of which always exhibited either moderate or marked enhancement following intravenous applications of Gd-DTPA, resulting in a typical appearance. Furthermore, T1- and T2-weighted hyperintense areas within the lesion were seen in many patients due to focal hemorrhage. No linear time correlation between the clinical symptom pain and focal areas of hemorrhage as shown by MRI, could be established. (orig.)

  7. Fibrous dysplasia of the jaws associated with secondary hyperparathyroidism: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Whi, Jung Hyun; Kim, Young Joo; Chun, Kyung Ah; Kim, Ki Tae; Chang, Eun Deok; Kim, Young Ok; Lee, Won [The Catholic University of Korea, Uijongbu (Korea, Republic of)

    2007-06-15

    There have been few reports on fibrous dyplasia associated with secondary hyperparathyroidism. We report a case of a hemodialysis patient with secondary hyperparathyroidism concomitant with fibrous dysplasia of the jaws causing an abnormal deformity.

  8. Undifferentiated Pleomorphic Sarcoma of the Cheek with Surface Ulceration: Mimicking Spindle Cell Squamous Cell Carcinoma

    OpenAIRE

    Fumiko Momma; Chihiro Onami; Takayuki Konno; Tamio Suzuki

    2013-01-01

    Undifferentiated pleomorphic sarcoma (UPS), also called malignant fibrous histiocytoma (MFH), belongs to the soft tissue tumors and is more likely in elder patients. UPS currently accounts for approximately 18% of cutaneous soft tissue sarcoma except Kaposi sarcoma. The most common sites are the extremities and head and neck. UPS is rapidly enlarging, and easily invades subcutaneous tissue and muscle without overlying skin changes. UPS tumors, which are confined to subcutaneous tissue, h...

  9. Long-term survivor of relapsed MFH on the thigh treated with autologous formalin-fixed tumor vaccine (AFTV) combined with limb-sparing surgery and radiotherapy

    OpenAIRE

    Morishita Yukio; Sugahara Shinji; Kondo Tadashi; Todoroki Takeshi; Mori Kensaku; Ohno Tadao

    2011-01-01

    Abstract Malignant fibrous histiocytoma (MFH) is an aggressive spindle cell cancer of soft-tissue sarcoma type in the elderly, mostly affecting the extremities. Lesions > 5 cm, positive margins, and local recurrence are significant poor prognostic indicators. The strongest predictor for distant metastasis was tumor size (> 5 cm), and for overall survival, presence of local recurrence. Limb-sparing extensive tumor resection is preferred to achieve negative surgical margins. However, in some ci...

  10. Long-term survivor of relapsed MFH on the thigh treated with autologous formalin-fixed tumor vaccine (AFTV) combined with limb-sparing surgery and radiotherapy

    OpenAIRE

    Todoroki, Takeshi; KONDO, TADASHI; SUGAHARA, SHINJI; Morishita, Yukio; Mori, Kensaku; Ohno, Tadao

    2011-01-01

    Malignant fibrous histiocytoma (MFH) is an aggressive spindle cell cancer of soft-tissue sarcoma type in the elderly, mostly affecting the extremities. Lesions > 5 cm, positive margins, and local recurrence are significant poor prognostic indicators. The strongest predictor for distant metastasis was tumor size (> 5 cm), and for overall survival, presence of local recurrence. Limb-sparing extensive tumor resection is preferred to achieve negative surgical margins. However, in some circumstanc...

  11. Dedifferentiated Liposarcoma in the Retroperitoneum in an Atomic Bomb Survivor: Report of a Case

    OpenAIRE

    Nakamura, Yukio; Yumiba, Takeyoshi; Yamasaki, Yoshio; Momiyama, Takuya; Ito, Akira; Akamaru, Yusuke; Kasugai, Tsutomu

    2008-01-01

    A 76-year-old Japanese man was admitted to Kosei-Nenkin Hospital (Osaka, Japan) in November 2006; his chief complaint was a 10-kg loss in body weight over 3 months prior to admission. Abdominal computed tomography (CT) and dynamic magnetic resonance imaging (MRI) showed three masses in the retroperitoneum. The patient subsequently underwent surgery. The final histopathological diagnosis of tumors 1 and 2 was malignant fibrous histiocytoma of the retroperitoneum, and tumor 3 was a well-differe...

  12. Analysis of Multiple Sarcoma Expression Datasets: Implications for Classification, Oncogenic Pathway Activation and Chemotherapy Resistance

    OpenAIRE

    Fountzilas, Elena; Bhasin, Manoj; Pillay, Kamana; Francoeur, Nancy; Konstantinopoulos, Panagiotis; Goldsmith, Jeffrey David; Libermann, Towia Aron; Gebhardt, Mark Clyde; Spentzos, Dimitrios

    2010-01-01

    Background: Diagnosis of soft tissue sarcomas (STS) is challenging. Many remain unclassified (not-otherwise-specified, NOS) or grouped in controversial categories such as malignant fibrous histiocytoma (MFH), with unclear therapeutic value. We analyzed several independent microarray datasets, to identify a predictor, use it to classify unclassifiable sarcomas, and assess oncogenic pathway activation and chemotherapy response. Methodology/Principal Findings: We analyzed 5 independent datasets ...

  13. Positive gallium-67 citrate uptake in a patient with polyostotic fibrous dysplasia

    International Nuclear Information System (INIS)

    Fibrous dysplasia is an uncommon bone condition with characteristic radiologic features. It is well known that there is increased uptake of Tc-99m hydroxymethylene diphosphonate (HMDP) and methylene diphosphonate (MDP) in fibrous dysplasia. There are no reports of uptake of Ga-67 citrate by fibrous dysplasia. A case is reported in which positive Ga-67 uptake was seen in a patient with polyostotic fibrous dysplasia

  14. Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma

    Science.gov (United States)

    2014-09-08

    Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Childhood Alveolar Soft-part Sarcoma; Childhood Angiosarcoma; Childhood Epithelioid Sarcoma; Childhood Fibrosarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Mesenchymoma; Childhood Neurofibrosarcoma; Childhood Synovial Sarcoma; Dermatofibrosarcoma Protuberans; Metastatic Childhood Soft Tissue Sarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Stage I Adult Soft Tissue Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

  15. Electrospinning of caseinates to create protective fibrous mats

    Science.gov (United States)

    JUSTIFICATION Electrospinning is a nonthermal process that produces fibers with diameters on the micron- or nano-scales from a polymer solution. If produced by electrospinning of biopolymer solutions, fibrous mats may be created for protecting foods, improving food quality and allowing for the prese...

  16. Electrospinning of casemates to create protective fibrous mats

    Science.gov (United States)

    Electrospinning is a nonthermal process that produces fibers on the micron- or nano-scale from a polymer solution. If produced by electrospinning of biopolymer solutions, fibrous mats may be created for protecting foods and allowing for the preservation and controlled release of bioactives for healt...

  17. Fibrous glass insulation and cancer: response and rebuttal.

    Science.gov (United States)

    Infante, P F; Schuman, L D; Huff, J

    1996-07-01

    In response to our commentary on fibrous glass and cancer [Infante et al., 1994], three letters have been received by the journal. The arguments put forth in these letters do not lead us to alter our scientific view that fibrous glass insulation is carcinogenic. No information is given in the letters that has not previously been stated. Even though these letters raise the same diaphanous arguments, we believe that to preserve occupational and public health we must respond in detail to ensure that the contentions of the fibrous glass industry do not gain further acceptance. Thus, we respond to each letter in turn: The first by Weiss questions and distorts epidemiologic findings, the second by McConnell attempts to recant his past views on the carcinogenicity of fibrous glass and on the value of rodent bioassays in general, and the third by Hesterberg and Chase impugns our analyses demonstrating a positive cancer response in their study. Lastly, we have not debated every issue raised in these three letters because of space limitations, and have centered our responses on what we consider the major incongruities and falsities in each letter. Likewise, we have been selective in citing only relevant literature, or those reports used by the industry or its consultants to support their views. PMID:16374937

  18. Thermal protection studies of plastic films and fibrous materials

    Science.gov (United States)

    Saad, Michel A.; Altman, Robert L.

    1988-01-01

    The thermal protection properties of various film and woven materials were studied using an experimental method of radiant heating. The materials studied included aluminized and unaluminized synthetic plastic films and fibrous materials like silicon carbide and phenolic novolac. It is shown that a thin metallized coating with good reflectivity significantly enhances the heat blocking capability of a variety of insulative materials.

  19. Failure Regimes in (1+1)d in Fibrous Materials

    CERN Document Server

    Menezes-Sobrinho, I L; Moreira, J G

    2001-01-01

    In this work, we introduce a model for fracture in fibrous materials which take into account the rupture height of the fibers, in contrast with previous models. Thus, we obtain the profile of the fracture and calculate its roughness, defined as the variance around the mean height. We investigate the relationship between the fracture roughness and the fracture toughness.

  20. Physical properties of collagen fibrous networks derived from bovine hides

    Science.gov (United States)

    The hides and leather industry has been facing a serious challenge in the disposal of solid wastes such as trimmings and lime-splits. One strategy to solve this problem is to convert these wastes into useful fibrous products and green composites. Therefore research is needed to investigate the pre...

  1. Solitary Fibrous Tumour of the Pleura 鈥 Cases Analysis

    International Nuclear Information System (INIS)

    Isolated fibrous tumor of the pleura (SFTP 鈥 Solitary fibrous tumour of the pleura/localized fibrous tumour of the pleura) is a rare primary tumour of the pleura of mesenchymal origin. In most cases, it is a benign lesion. It is composed of spindle cells similar to fibroblasts and derives probably from submesothelial mesenchyme. The aim of the study was to analyze clinical symptoms, incidence, possibility of suggesting the diagnosis on the basis of imaging tests, and confirmation of the diagnosis in pathological tests with regard to studies of histochemistry examination. Clinical and morphological material obtained from 14 patients from Department of Thoracic Surgery of Subcarpathian Chest Disease Center treated between year 2004 and 2010 was analysed. In the first stage, selected cases of patients with isolated fibrous tumour of the pleura were chosen from the archives and the analysis of their medical history was carried out. Basic information about age, gender, medical history, smoking habit, physical examination and results of imaging, endoscopic and morphological examinations were noted. The second parallel component of the study was pathomorphological examinations of the surgical material obtained from the patients, including the assessment of morphology and immunohistochemistry. Of the 14 examined patients, fibrous tumour occurred in 8 men and 6 women. The age range of the patients was 37鈥73 years, with a peak attributable to the 6th decade of life. In 8 patients the tumour was detected incidentally during routine examinations. In 7 patients there were no clinical signs of respiratory disease, and if present, then the most common complaint was shortness of breath. Regarding symptoms not connected with the respiratory system, anemia occurred most frequently. Fibrous tumour of the pleura was more often associated with the visceral pleura than with the parietal pleura. The largest lesion was approximately 20 cm in size. Fibrous tumour of the pleura is a pleura-based neoplasm which is usually detected incidentally, and is often asymptomatic or poorly symptomatic. Computed tomography imaging allows to suggest a correct diagnosis. Histopathological diagnosis is based on immunohistochemical examinations

  2. Neurofibromatosis and fibrous dysplasia manifesting in the same patient: a rare case report.

    Science.gov (United States)

    Sujatha, Sampangi; Jatti, Deepa

    2015-02-01

    Neurofibromatosis and fibrous dysplasia show the presence of caf茅-au-lait spots, bone lesions, and endocrinopathies. There has been speculation whether neurofibromatosis and fibrous dysplasia are different manifestations of the same disease or if these conditions are in some way related. We provide a case of whether neurofibromatosis and fibrous dysplasia complicated by hyperparathyroidism and osteoporosis. PMID:24000123

  3. Malignant vagal paraganglioma

    DEFF Research Database (Denmark)

    Carlsen, Camilla S; Godballe, Christian; Krogdahl, Annelise S; Edal, Anette L

    2003-01-01

    Approximately 20 cases of malignant vagal paragangliomas (MVP)have been reported in English literature. Malignancy is based on the presence of metastases. A careful preoperative evaluation is necessary to detect multicentricity and/or significant production of catecholamines. A new case of MVP tr...

  4. Primary ovarian malignant melanoma

    Directory of Open Access Journals (Sweden)

    Kostov Milo拧

    2010-01-01

    Full Text Available Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

  5. Solitary fibrous tumor of the breast: report of a case with emphasis on diagnostic role of STAT6 immunostaining.

    Science.gov (United States)

    Magro, Gaetano; Angelico, Giuseppe; Leone, Giorgia; Palazzo, Juan

    2016-05-01

    We herein report the clinical, radiological, and pathological findings of a rare case of a solitary fibrous tumor (SFT) occurring in the breast parenchyma of a 62-year-old female. The tumor was incidentally detected at a mammographic screening, and, ultrasonographically, presented as a single, well-circumscribed nodule. On needle core biopsy, the diagnosis of SFT was suggested based on a proliferation of CD34-positive spindly cells set in a fibrous stroma containing medium-sized blood vessels with hyalinization of their walls and branching configuration. The diagnosis was confirmed in the excised specimen, which exhibited a tumor with an immunohistochemical profile consistent with SFT, including diffuse expression of CD34, CD99 and bcl2. As STAT6 nuclear immunoexpression is the result of the inv12(q13q13)-derived NAB2-STAT6 fusion, which characterizes SFT, we analyzed immunohistochemically our case with a commercially available anti-STAT6 antibody. We showed that mammary SFT exhibits a diffuse nuclear STAT6 immunoreactivty, suggesting its potential diagnostic role. The present case emphasizes that the diagnosis of SFT can be confidentially rendered on needle core biopsy. Although SFT is suspected on characteristic morphologic features, immunohistochemistry, revealing immunoreactivity for CD34, bcl-2, CD99 and STAT6, is crucial in the differential diagnosis of potential benign and malignant mimics. PMID:26778386

  6. 3D CHARACTERIZATION OF WOOD BASED FIBROUS MATERIALS: AN APPLICATION

    Directory of Open Access Journals (Sweden)

    J閞鬽e Lux

    2011-05-01

    Full Text Available Morphological characterization of wood based fibrous materials is carried out using X-ray tomography. This technique allows the non destructive observation at the scales of a fibre (microscopic scale and of a network of fibres (mesoscopic scale. The 3D images are processed using classical tools of mathematical morphology. Measures of porosities and estimations of the size distributions of fibres and pores are carried out and compared to other results. An alternative method for the calculation of the local orientation of the fibres is also described to quantify the anisotropy of the fibres network. Finally, the individualization of the fibres is obtained from the representation of the fibrous network as a 3D skeleton, making possible further measurements on the isolated fibres.

  7. Carbon-based fibrous EDLC capacitors and supercapacitors

    OpenAIRE

    Watts, J. F.; Andrews, T.; Markoulidis, F; O. Moudam; C. Lekakou; Reed, G. T.

    2011-01-01

    This paper investigates electrochemical double-layer capacitors (EDLCs) including two alternative types of carbon-based fibrous electrodes, a carbon fibre woven fabric (CWF) and a multiwall carbon nanotube (CNT) electrode, as well as hybrid CWF-CNT electrodes. Two types of separator membranes were also considered. An organic gel electrolyte PEO-LiCIO4-EC-THF was used to maintain a high working voltage. The capacitor cells were tested in cyclic voltammetry, charge-discharge, and impedance test...

  8. Directionally oriented fibrous structures for llghtweight concrete elements reinforcement

    OpenAIRE

    Fangueiro, Ra鷏, ed. lit.; Marques, P.; Pereira, C. Gonilho

    2010-01-01

    This paper reports on the work that is being undertaken at the University of Minho concerning the development of directionally oriented fibrous structures (DOFS) to be used as a concrete reinforcement material. Several glass fibre wovenlike DOFS were produced varying two parameters: roving linear density (tex) and reinforcement structural density (rovings/ cm). Self-compacting concrete slabs were reinforced by DOFS structures and their bending behaviour was evaluated. The resul...

  9. Properties of nanoparticles affecting simulation of fibrous gas filter performance

    OpenAIRE

    Tronville, Paolo Maria

    2014-01-01

    Computational Fluid Dynamics (CFD) software now widely available allows detailed simulation of the flow of gases through fibrous filter media. When the pattern of gas velocity vectors in the interstices between fibers has been established, a simulated particle of any desired size can be "injected" into the entering gas stream, and its path under the influence of aerodynamic drag, Brownian motion, electrostatic forces and thermal gradients traced, until the particle either collides with a fibe...

  10. The Fibrous Form Confers Unique Properties on Materials

    OpenAIRE

    Bondy, Stephen C.

    2014-01-01

    The main distinguishing feature of the fiber is simply that it is a particle where the ratio of length to width ratio is very large. This provides connectivity between two relatively remote areas. Such linkage may confer strength through physical linkage or may relate primarily to information transfer. In the inorganic world, fibers can originate as a result of the process by which the solid material is condensed from the corresponding liquid form. Man-made fibrous materials are essentially p...

  11. Interfacial Micromechanics in Fibrous Composites: Design, Evaluation, and Models

    OpenAIRE

    Zhenkun Lei; Xuan Li; Fuyong Qin; Wei Qiu

    2014-01-01

    Recent advances of interfacial micromechanics in fiber reinforced composites using micro-Raman spectroscopy are given. The faced mechanical problems for interface design in fibrous composites are elaborated from three optimization ways: material, interface, and computation. Some reasons are depicted that the interfacial evaluation methods are difficult to guarantee the integrity, repeatability, and consistency. Micro-Raman study on the fiber interface failure behavior and the main interface m...

  12. Olfactory dysfunction as first presenting symptom of cranial fibrous dysplasia

    OpenAIRE

    Tsakiropoulou, Evangelia; Konstantinidis, Iordanis; Chatziavramidis, Angelos; Constantinidis, Jannis

    2013-01-01

    Fibrous dysplasia (FD) is a benign bone disorder presenting with a variety of clinical manifestations. This is the first reported case of anosmia as presenting symptom of FD. We present the case of a 72-year-old female patient with a progressive olfactory dysfunction. Clinical examination revealed evidence of chronic rhinosinusitis; therefore the patient was treated with a course of oral corticosteroids. The patient had no improvement in her olfactory ability and imaging studies were ordered....

  13. Configuration of Fibrous and Adipose Tissues in the Cavernous Sinus

    OpenAIRE

    Liang LIANG; Gao, Fei; Xu, Qunyuan; Zhang, Ming

    2014-01-01

    Objective Three-dimensional anatomical appreciation of the matrix of the cavernous sinus is one of the crucial necessities for a better understanding of tissue patterning and various disorders in the sinus. The purpose of this study was to reveal configuration of fibrous and adipose components in the cavernous sinus and their relationship with the cranial nerves and vessels in the sinus and meningeal sinus wall. Materials and Methods Nineteen cadavers (8 females and 11 males; age range, 54鈥89...

  14. Towards a Numerical Model of Bacterial Filtration in Fibrous Filters

    OpenAIRE

    Gac Jakub M.; Grado艅 Leon

    2015-01-01

    A model of bacterial filtration on fibrous filter media is developed. The single fibre efficiency as well as the efficiency of the whole filter - at the onset of the process and the evolution of those quantities - are analysed. The differences between the numerical modelling of colloidal particles and bacteria are stressed in detail. The main differences are the active motion ability of bacteria and biofilm formation. The parameters of the model were identified based on the literature data.

  15. Towards a Numerical Model of Bacterial Filtration in Fibrous Filters

    Directory of Open Access Journals (Sweden)

    Gac Jakub M.

    2015-03-01

    Full Text Available A model of bacterial filtration on fibrous filter media is developed. The single fibre efficiency as well as the efficiency of the whole filter - at the onset of the process and the evolution of those quantities - are analysed. The differences between the numerical modelling of colloidal particles and bacteria are stressed in detail. The main differences are the active motion ability of bacteria and biofilm formation. The parameters of the model were identified based on the literature data.

  16. Radiologic Features of Fibrous Hamartoma of Infancy Involving the Buttocks

    International Nuclear Information System (INIS)

    Fibrous hamartoma of infancy (FHI) is a rare benign subcutaneous tumor that presents in children younger than two years. The tumor mostly affects the trunk, axilla and upper extremities. Imaging findings of FHI that involve the buttocks have not been reported in the clinical literature. We reported the imaging features of a lesion in a 9-month-old infant who presented with a palpable mass on the buttocks. The imaging findings were evaluated after a review of previous studies

  17. Recurring fibrous dysplasia of anthro maxillary with cranial base invasion

    OpenAIRE

    Sousa, K醫ia Maria Marabuco de; Costa, K醨los Jader S醫iro de Mendon鏰; Holanda, Thiago Ayres; Silva, Thiago Oliveira e; Cunha, Rafael Levi Louchar Silva da; Soares, V韙or Yamashiro Rocha

    2009-01-01

    Introduction: Fibrous dysplasia is an osseous lesion with an unknown etiology. It is characterized by the osseous maturation insufficiency. It may affect any bone, but the affection of craniofacial bones is the most critical for otorhinolaryngology. Maxilla is the most affected facial bone and the orbitary invasion is an uncommon event. The symptoms are unspecific and for its low suspicion and uncommonness, the diagnosis is generally late. The monostotic form presents a slow growth and asympt...

  18. Feed Technology of Fibrous Sugarcane Residues for Ruminants

    Directory of Open Access Journals (Sweden)

    Kuswandi

    2007-06-01

    Full Text Available Abundant sugarcane residue during shortage of roughage in dry season gives an opportunity to raise ruminants around sugarcane industries. However, these products are not widely used by farmers due to an assumption that the usage is inefficient and that the feed utilization technology is not widely recognized. Sugarcane fibrous residues (tops, bagasse and pith may be a potential feed component if pre-treated to increase its digestion and consumption by the animal, and/or supplemented by other ingredients to balance nutrients in the rumen as well as those for production purpose. Digestibility can be increased by chemical treatments such as ammoniation and other alkaline treatments, whereas consumption can be increased by physical treatments such as grinding, hammermilling or pelleting. Nutrients that are missing in these fibrous residues can be provided by addition of urea, molasses and minerals for maintenance need, and bypass nutrients (carbohydrates, protein and fats that are digested in the small intestine and available for tissue or milk synthesis. There are three options for development of livestock agribusiness based on fibrous sugarcane residues; however, these require several technologies to optimize the utilization of these residues.

  19. Erosive separation of organic coatings from fibrous substrates.

    Science.gov (United States)

    Weiss, M; Momber, A W

    2004-11-01

    The separation of organic coatings from fibrous substrates is a key problem in recycling processes. This problem applies to carpets, technical textiles and automotive interior components. This paper reports about results of laboratory studies involving the application of high-speed liquid jets to solve this problem. Results from high-speed video images are used to qualify the principal erosion process. It is shown that the coating material is first ground by the jet; the generated erosion debris is then pushed through the permeable fibrous fabric of the substrate. It is also found that threshold conditions exist for the coating grinding process and for the debris transportation. These threshold conditions depend on target composition and process parameters. A phenomenological separation model is introduced. The influence of key process parameters, namely jet velocity, exposure time, stand-off distance and impact angle, is also investigated. It is found that high-speed liquid jets are suitable tools for separating organic coatings completely and selectively from fibrous substrates. Recommendations on how to optimise the erosion process are derived from the results. PMID:15474739

  20. The Current Status of Solitary Fibrous Tumor: Diagnostic Features, Variants, and Genetics.

    Science.gov (United States)

    Thway, Khin; Ng, Wen; Noujaim, Jonathan; Jones, Robin L; Fisher, Cyril

    2016-06-01

    Solitary fibrous tumor (SFT) is a fibroblastic mesenchymal tumor originally described in the pleura but now shown at almost every anatomic site. Histopathologically, SFT is characteristically a circumscribed neoplasm composed of variably cellular and patternless distributions of bland spindle and ovoid cells within prominent collagenous stroma and shows diffuse expression of CD34, but it has a broad spectrum of both morphology and of biologic behavior. Many different names (particularly hemangiopericytoma) were previously used in the course of our understanding of this neoplasm but are now subsumed under the term "SFT," and the putative cell of origin was debated. However, it is now recognized that SFT is a translocation-associated neoplasm, consistently associated with NAB2-STAT6 gene fusions arising from recurrent intrachromosomal rearrangements on chromosome 12q, and this translocation is a likely major contributor to its pathogenesis. While most SFT with classical morphologic features behave in an indolent manner and those with overtly malignant histologic features tend to be aggressive neoplasms that behave as high-grade sarcomas, the behavior of SFT is unpredictable, and it is important to be aware of the propensity for aggressive behavior in a minority of histologically classical SFT and to ensure adequate clinical follow-up. Surgical excision remains the treatment gold standard; while radiotherapy and conventional chemotherapeutic agents have only shown limited efficacy, further understanding of the molecular events underlying tumorigenesis may allow the development of novel targeted treatments. We review SFT, discussing the morphologic spectrum and variants, including malignant and dedifferentiated subtypes, clinicopathological aspects, recent molecular genetic findings, and the differential diagnosis. PMID:26811389

  1. Giant solitary fibrous tumor of the pleura causing respiratory insufficiency: report of 3 cases.

    Science.gov (United States)

    Abe, Masaru; Nomori, Hiroaki; Fukazawa, Motoji; Sugimura, Hiroshi; Narita, Makoto; Takeshi, Akihiko

    2014-01-01

    We present 3 cases of solitary fibrous tumors (SFTs) occupying entire hemithorax and resulting in respiratory insufficiency. All patients were treated by complete resection, resulting in immediate re-expansion of the lungs and recovery from respiratory insufficiency. Although, two patients remain alive without recurrence, one patient had pleural recurrences three times over a 20-year period, all of which were treated by surgical resection. All of the primary tumors exhibited areas of hypercellularity, hemorrhage, or necrosis. All of the recurrent tumors in the recurrent case displayed large areas of hypercellularity, similar to the part of primary tumor. Although, the MIB-1 index in primary tumors was less than 5%, the index of the recurrent tumors increased up to 11% with repeated recurrence. Giant SFTs usually display hypercellularity, hemorrhage, or necrosis. Tumors with hypercellularity could recur. MIB-1 index could display malignant characteristics of recurrent tumors. Long-term follow-up for more than 10 years after surgery is necessary, particularly for tumors with areas of hypercellularity. PMID:24088920

  2. Fibrous dysplasia mimicking bone metastasis on both bone scintigraphy and {sup 18}F FDG PET CT: Diagnostic dilemma in a patient with breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    KC, Sud Hir Suman; Sharma, Punit; Singh, Har Man Deep; Bal, Chand Rasekhar; Kumar, Rake Sh [India Institute of Medical Sciences, New Delhi (India)

    2012-12-15

    Bone is the most common distant site to which breast cancer metastasizes. Commonly used imaging modalities for imaging bone metastasis are bone scintigraphy, plain radiography, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Although bone scintigraphy gas high sensitivity for detecting bone metastasis, its specificity is low. This is because of the fact that bone scintigraphy images secondary changes in bone rather than just tumor cells {sup 18}F fluorodeoxyglucose ({sup 18}F FDG) PET CT, on the other hand, directly images the tumor cells' glucose metabolism. Unfortunately, similar to bone scintigraphy, benign bone conditions can also show increased {sup 18}F FDG uptake on PET CT, and PET positive asymptomatic fibrous dysplasia can be misinterpreted as a metastasis. Fibrous dysplasia of bone has wide skeletal distribution, with variability of {sup 18}F FDG uptake and CT appearance. It is therefore important to recognize the characteristics of this skeletal dysplasia, to allow differentiation from skeletal metastasis. Bone lesions with {sup 18}F FDG uptake need to be carefully interpreted when evaluating patients with known malignancy. In doubtful cases, fibrous dysplasia should be given as a differential diagnosis and histopathological diagnosis may be warranted, as highlighted in the present case.

  3. Fibrous dysplasia mimicking bone metastasis on both bone scintigraphy and 18F FDG PET CT: Diagnostic dilemma in a patient with breast cancer

    International Nuclear Information System (INIS)

    Bone is the most common distant site to which breast cancer metastasizes. Commonly used imaging modalities for imaging bone metastasis are bone scintigraphy, plain radiography, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Although bone scintigraphy gas high sensitivity for detecting bone metastasis, its specificity is low. This is because of the fact that bone scintigraphy images secondary changes in bone rather than just tumor cells 18F fluorodeoxyglucose (18F FDG) PET CT, on the other hand, directly images the tumor cells' glucose metabolism. Unfortunately, similar to bone scintigraphy, benign bone conditions can also show increased 18F FDG uptake on PET CT, and PET positive asymptomatic fibrous dysplasia can be misinterpreted as a metastasis. Fibrous dysplasia of bone has wide skeletal distribution, with variability of 18F FDG uptake and CT appearance. It is therefore important to recognize the characteristics of this skeletal dysplasia, to allow differentiation from skeletal metastasis. Bone lesions with 18F FDG uptake need to be carefully interpreted when evaluating patients with known malignancy. In doubtful cases, fibrous dysplasia should be given as a differential diagnosis and histopathological diagnosis may be warranted, as highlighted in the present case

  4. Mesenchymal breast lesions.

    Science.gov (United States)

    Schickman, R; Leibman, A J; Handa, P; Kornmehl, A; Abadi, M

    2015-06-01

    Mesenchymal breast lesions encompass a variety of breast diseases. Many of these lesions are rare with only a few case reports in the literature. This article reviews the imaging findings of selected mesenchymal breast lesions, their clinical presentations and method of diagnosis. Mesenchymal lesions are diverse and include haemangioma, granular cell tumour, myofibroblastoma, fibromatosis, pseudoangiomatous stromal hyperplasia, and malignant fibrous histiocytoma. It is important for radiologists to be aware of these lesions as some of them may have malignant potential or demonstrate imaging features that overlap with other malignant lesions. PMID:25638601

  5. Mesenchymal breast lesions

    International Nuclear Information System (INIS)

    Mesenchymal breast lesions encompass a variety of breast diseases. Many of these lesions are rare with only a few case reports in the literature. This article reviews the imaging findings of selected mesenchymal breast lesions, their clinical presentations and method of diagnosis. Mesenchymal lesions are diverse and include haemangioma, granular cell tumour, myofibroblastoma, fibromatosis, pseudoangiomatous stromal hyperplasia, and malignant fibrous histiocytoma. It is important for radiologists to be aware of these lesions as some of them may have malignant potential or demonstrate imaging features that overlap with other malignant lesions

  6. Radioimmunotherapy of malignant gliomas; Radioimmuntherapie maligner Gliome

    Energy Technology Data Exchange (ETDEWEB)

    Poepperl, G.; Tatsch, K. [Klinik und Poliklinik fuer Nuklearmedizin, Klinikum der Univ. Muenchen, Campus Grosshadern, Muenchen (Germany)

    2008-06-15

    Despite all technical advances (intraoperative resection control, fluorescence guided resection, advances in external beam radiation techniques) and new consolidated findings on systemic chemotherapy treatment of malignant gliomas with conventional therapeutic modalities (surgery, radiation therapy and chemotherapy) is still highly unfavourable. Total tumor erradication is impossible due to tumor infiltrations into the normal brain and the limitations given by the limited tolerance of surrounding brain tissue. New treatment strategies, therefore, aim for a more selective destruction of tumor cells. Malignant glioma cells selectively express several antigens or receptors which are not or only to a minor extent present in normal brain tissue. Administration of radiolabelled monoclonal antibodies, especially when given locoregionally, targeting these tumor-specific antigens offers an innovative therapeutic strategy that has recently demonstrated encouraging antitumor effects and acceptable toxicity in many phase I/II clinical trials. This review offers a comprehensive summary of own experiences and results of clinical trials reported in the literature dealing with radioimmunotherapy of malignant glioma and highlights future plans to further develop this therapeutic strategy. (orig.)

  7. Asbestos-related malignancy

    Energy Technology Data Exchange (ETDEWEB)

    Antmann, K.; Aisner, J.

    1986-01-01

    This book contains 20 chapters. Some of the chapter titles are: The Radiology of Asbestosis and Related Neoplasms; Computed Tomography and Malignant Mesothelioma; Radiation Therapy for Pleural Mesothelioma; and Radiation Therapy of Peritoneal Mesothelioma.

  8. Asbestos-related malignancy

    International Nuclear Information System (INIS)

    This book contains 20 chapters. Some of the chapter titles are: The Radiology of Asbestosis and Related Neoplasms; Computed Tomography and Malignant Mesothelioma; Radiation Therapy for Pleural Mesothelioma; and Radiation Therapy of Peritoneal Mesothelioma

  9. Imaging malignant and apparent malignant transformation of benign gynaecological disease

    Energy Technology Data Exchange (ETDEWEB)

    Lee, A.Y.; Poder, L.; Qayyum, A.; Wang, Z.J.; Yeh, B.M. [Department of Radiology, University of California San Francisco, San Francisco, CA (United States); Coakley, F.V., E-mail: Fergus.Coakley@radiology.ucsf.ed [Department of Radiology, University of California San Francisco, San Francisco, CA (United States)

    2010-12-15

    Common benign gynaecological diseases, such as leiomyoma, adenomyosis, endometriosis, and mature teratoma, rarely undergo malignant transformation. Benign transformations that may mimic malignancy include benign metastasizing leiomyoma, massive ovarian oedema, decidualization of endometrioma, and rupture of mature teratoma. The aim of this review is to provide a contemporary overview of imaging findings in malignant and apparent malignant transformation of benign gynaecological disease.

  10. Managing Malignant Cerebral Infarction

    OpenAIRE

    Simard, J. Marc; Sahuquillo, Juan; Sheth, Kevin N; Kahle, Kristopher T.; Walcott, Brian P.

    2011-01-01

    Managing patients with malignant cerebral infarction remains one of the foremost challenges in medicine. These patients are at high risk for progressive neurologic deterioration and death due to malignant cerebral edema, and they are best cared for in the intensive care unit of a comprehensive stroke center. Careful initial assessment of neurologic function and of findings on MRI, coupled with frequent reassessment of clinical and radiologic findings using CT or MRI are mandatory to promote t...

  11. Unusual Malignant Breast Lesions

    OpenAIRE

    D. Farrokh; B Zandi (Ph.D); J.B. Hashemi

    2007-01-01

    Numerous unusual benign and malignant breast le-sions may be seen occasionally or rarely. Some of these lesions are distinctive and easily recognized be-cause of diagnostic clinical or radiographic criteria such as inflammatory carcinoma or Paget's disease, which are primarily a clinical diagnosis. Most of the unusual malignant breast lesions have no specific di-agnostic signs and may show the mammographic or ultrasonic findings of benign lesions. Although most radiologists may never see...

  12. Malignancy-associated pruritus.

    Science.gov (United States)

    Rowe, B; Yosipovitch, G

    2016-01-01

    Malignancy-associated pruritus can be the result of a neoplasm's local effect on tissue or due to the systemic reaction to malignancy. A systemic reaction to malignancy has been termed 'paraneoplastic itch' and can be the first sign of an underlying malignancy. Paraneoplastic itch is most commonly caused by lymphoproliferative malignancies, and severity of itch correlates with stage of disease in Hodgkin's lymphoma and polycythemia vera. Non-melanoma skin cancer is the most common type of malignancy-associated pruritus, and recent data indicate that pruritus is associated with more than one-third of non-melanoma skin cancers. Cutaneous T-cell lymphomas (CTCL), particularly more advanced stages, cause intractable pruritus and recent investigations into the pathophysiology of CTCL-associated itch have implicated cyotokine interleukin-31 as a putative mediator. Treatments that reduce itch in CTCL patients, such as histone deacetylase inhibitors (HDACi), Mogamulizumab, a novel monoclonal antibody against chemokine receptor type-4, and oral corticosteroids, have demonstrated a correlation between their anti-pruritic effect and reduced serum levels of interleukin-31. PMID:26416212

  13. Management of malignant pleural effusions.

    LENUS (Irish Health Repository)

    Uzbeck, Mateen H

    2010-06-01

    Malignant pleural effusions are a common clinical problem in patients with primary thoracic malignancy and metastatic malignancy to the thorax. Symptoms can be debilitating and can impair tolerance of anticancer therapy. This article presents a comprehensive review of pharmaceutical and nonpharmaceutical approaches to the management of malignant pleural effusion, and a novel algorithm for management based on patients\\' performance status.

  14. Microstructure and properties of nano-fibrous PCL-b-PLLA scaffolds for cartilage tissue engineering

    OpenAIRE

    He, L.; Liu, B; G Xipeng; Xie, G.; S. Liao; Quan, D.; Cai, D; Lu, J.; Ramakrishna, S.

    2009-01-01

    Nano-fibrous scaffolds which could potentially mimic the architecture of extracellular matrix (ECM) have been considered a good candidate matrix for cell delivery in tissue engineering applications. In the present study, a semicrystalline diblock copolymer, poly(e-caprolactone)-block-poly(L-lactide) (PCL-b-PLLA), was synthesized and utilized to fabricate nano-fibrous scaffolds via a thermally induced phase separation process. Uniform nano-fibrous networks were created by quenching a PCL-b-PLL...

  15. Aggressive malignant abdominal mesothelioma: Clinical report

    International Nuclear Information System (INIS)

    A 32-year-old Filipino female, working as an x-ray technician, presented to the Emergency Room (ER) with acute abdominal pain for one day. The pain was mainly on the left side and left hypochondrium. She had recurring abdominal pain before but not significant to worry her. She also complained of abdominal distension, which she noticed one week ago. Abdominal examination revealed fullness in the left hypochondrium with marked tenderness but negative rebound. Abdominal ultrasound (US) showed a huge mass mainly in the left hypochondrium. The origin of the mass cannot be identified by US. A computerized tomography scan showed a mass in the left side of the abdomen crossing the midline with a necrotic centre. The hospital course of the patient runs smoothly, and she was discharged after 7-days and referred to an Oncology Center. Abdominal mesothelioma is a neoplasm arising from the mesothelial surface lining the abdominal cavity. It is less frequent than that of the pleura. It is a rapidly growing and fatal malignancy with a median survival of less than 1-year. The relation between pleural malignant mesothelioma and asbestos is well recognized since it was described in 19602 but implication of asbestos exposure in the etiology of the peritoneal type is less obvious. This patient history is giving no obvious exposure to asbestos but as she is working in the Radiology Department as an x-ray technician she is well exposed to x-ray, but the effect of radioactivity on induction of mesothelioma is still disputed.4 There are several reports linking malignant mesothelioma to radioactivity due to radiation therapy.The fibrous mesothelioma (sarcomatous), as in this case, which is difficult to diagnose microscopically, looks like a fibroma, unless helped by tissue culture. The treatment options of malignant mesothelioma include surgery, intraperitoneal chemotherapy and whole abdominal radiation or multimodality therapy, which were suggested that might prolong the survival in patients with peritoneal mesothelioma.5 Although peritoneal mesothelioma is rare, progress in its management has occurred, survival has been extended and selection factors by which patients may be allocated to aggressive management strategies have been defined

  16. Permeability and compression of fibrous porous media generated from dilute suspensions of fiberglass debris during a loss of coolant accident

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Saya, E-mail: sayalee@tamu.edu; Abdulsattar, Suhaeb S.; Vaghetto, Rodolfo; Hassan, Yassin A.

    2015-09-15

    Highlights: 鈥 Experimental investigation on fibrous debris buildup was conducted. 鈥 Head loss through fibrous media was recorded at different approach velocities. 鈥 A head loss model through fibrous media was proposed for high porosity (>0.99). 鈥 A compression model of fibrous media was developed. - Abstract: Permeability of fibrous porous media has been studied for decades in various engineering applications, including liquid purifications, air filters, and textiles. In nuclear engineering, fiberglass has been found to be a hazard during a Loss-of-Coolant Accident. The high energy steam jet from a break impinges on surrounding fiberglass insulation materials, producing a large amount of fibrous debris. The fibrous debris is then transported through the reactor containment and reaches the sump strainers. Accumulation of such debris on the surface of the strainers produces a fibrous bed, which is a fibrous porous medium that can undermine reactor core cooling. The present study investigated the buildup of fibrous porous media on two types of perforated plate and the pressure drop through the fibrous porous media without chemical effect. The development of the fibrous bed was visually recorded in order to correlate the pressure drop, the approach velocity, and the thickness of the fibrous porous media. The experimental results were compared to semi-theoretical models and theoretical models proposed by other researchers. Additionally, a compression model was developed to predict the thickness and the local porosity of a fibrous bed as a function of pressure.

  17. Permeability and compression of fibrous porous media generated from dilute suspensions of fiberglass debris during a loss of coolant accident

    International Nuclear Information System (INIS)

    Highlights: 鈥 Experimental investigation on fibrous debris buildup was conducted. 鈥 Head loss through fibrous media was recorded at different approach velocities. 鈥 A head loss model through fibrous media was proposed for high porosity (>0.99). 鈥 A compression model of fibrous media was developed. - Abstract: Permeability of fibrous porous media has been studied for decades in various engineering applications, including liquid purifications, air filters, and textiles. In nuclear engineering, fiberglass has been found to be a hazard during a Loss-of-Coolant Accident. The high energy steam jet from a break impinges on surrounding fiberglass insulation materials, producing a large amount of fibrous debris. The fibrous debris is then transported through the reactor containment and reaches the sump strainers. Accumulation of such debris on the surface of the strainers produces a fibrous bed, which is a fibrous porous medium that can undermine reactor core cooling. The present study investigated the buildup of fibrous porous media on two types of perforated plate and the pressure drop through the fibrous porous media without chemical effect. The development of the fibrous bed was visually recorded in order to correlate the pressure drop, the approach velocity, and the thickness of the fibrous porous media. The experimental results were compared to semi-theoretical models and theoretical models proposed by other researchers. Additionally, a compression model was developed to predict the thickness and the local porosity of a fibrous bed as a function of pressure

  18. Displasia fibrosa de seno maxilar / Fibrous Dysplasia of Maxillary Sinus

    Scientific Electronic Library Online (English)

    Cecilia, Parlad Formell; Yamily, Gonz醠ez Cardona; Portelles Mass, Ayel閚 M; Julio O, Fuentes de la Rosa; Mirian, Vivar Bauz.

    2015-03-01

    Full Text Available La displasia fibrosa fue descrita por Lichtenstein en 1938, es una enfermedad caracterizada por el reemplazo progresivo de tejido 髎eo normal por una proliferaci髇 de tejido conectivo fibroso, por su forma de presentaci髇 se clasifica en monost髏ica o poliost髏ica. La forma monost髏ica, localizada e [...] n la regi髇 craneofacial constituye solo el 10 % de los casos, se presenta con mayor frecuencia en el maxilar superior y puede afectar a huesos adyacentes como el cigom醫ico, esfenoides y occipital. La degeneraci髇 sarcomatosa puede ocurrir en un 0,5 %. Se presenta el caso de una paciente femenina, de 37 a駉s de edad, operada ocho a駉s antes de displasia fibrosa en el Servicio de Cirug韆 M醲ilofacial del Hospital Vladimir I. Lenin, que luego de su embarazo y parto presenta un aumento de volumen en 醨ea malar y maxilar izquierdos, a la que se le realiza biopsia que da como resultado una recidiva. Se le realiza cirug韆 remodelativa de pared anterior de seno maxilar, a trav閟 de una incisi髇 de Weber-Ferguson, con buenos resultados est閠icos y funcionales. Abstract in english Fibrous dysplasia was described by Lichtenstein in 1938, is a progressive disease characterized by replacement of normal bone tissue by proliferation of fibrous connective tissue, its presentation is classified in monostotic or polyostotic. The monostotic form, located in the craniofacial region con [...] stitutes only 10 % of cases, it occurs most frequently in the maxilla and adjacent bones can affect as the zygomatic, sphenoid and occipital. The sarcomatous degeneration can occur in 0.5 %. A 37-year-old female patient, who underwent fibrous dysplasia surgery eight years ago at Maxillofacial Surgery Department of Vladimir I. Lenin Hospital, which after the pregnancy and delivery presented a volume increase in malar and left area is presented in this paper, biopsy is performed whose results showed a recurrence. Remodeling surgery was performed of anterior wall of the maxillary sinus through a Weber-Ferguson incision with good cosmetic and functional results.

  19. The use of fibrous ion exchangers in gold hydrometallurgy

    Science.gov (United States)

    Kautzmann, R. M.; Sampaio, C. H.; Cortina, J. L.; Soldatov, V.; Shunkevich, A.

    2002-10-01

    This article examines a family of ion-exchange fibers, FIBAN, containing primary and secondary amine groups. These ion exchangers have a fiber diameter of 20 40 ?m, high osmotic and mechanic stability, a high rate of adsorption and regeneration, and excellent dynamic characteristics as filtering media. Inparticular, this article discusses the use of FIBAN fibrous ion exchangers in the recovery of gold cyanide andbase-metal cyanides (copper and mercury) from mineral-leaching solutions. The influence of polymer structure and water content on their extraction ability is described, along with key parameters of gold hydrometallurgy such as extraction efficiency, selectivity, pH dependence, gold cyanide loading, kinetics, and stripping.

  20. Solitary fibrous tumor of the orbit presenting in pregnancy

    Directory of Open Access Journals (Sweden)

    Das Jayanta

    2009-01-01

    Full Text Available A 32-year-old woman, three months pregnant, reported with the complaint of protrusion of the right eye for six months. She gave history of rapid protrusion of eyeball for the last two months along with the history of double vision for the last one month. Computer tomography (CT scan revealed a well-defined mass lesion in the intraconal space of the right orbit which was excised through a lateral orbitotomy approach. Histological examination and immunohistochemistry revealed a solitary fibrous tumor, which showed a rapid progression in pregnancy.

  1. Characterization of three fibrous insulations for potential HTGR application

    International Nuclear Information System (INIS)

    Three fibrous insulation materials manufactured by Babcock and Wilcox were characterized for possible use as HTGR core thermal insulations. These materials (Unifelt 3000 board, Unifelt 2600 board, and Kaowool blanket) were characterized by spectrographic analysis, x-ray diffractometry, scanning electron microscopy, ignition studies and bulk density measurements, resilience tests, helium permeation tests, and compressive stress-strain tests. Of these properties, resilience is the most important for determining acceptability of material for HTGR use. The arbitrary resilience acceptability criterion is 90% or greater after 20 h at 8160C (15000F). Based on the resilience test, the Unifelt 3000 was acceptable, the Unifelt 2600 was marginal, and the Kaowool was unacceptable

  2. Scoliosis and spine involvement in fibrous dysplasia of bone

    OpenAIRE

    Mancini, Federico; Corsi, Alessandro; De Maio, Fernando; Riminucci, Mara; Ippolito, Ernesto

    2009-01-01

    Few studies focused on the prevalence of scoliosis and involvement of the spine in patients with fibrous dysplasia (FD) of bone. We examined for FD involvement of the spine and scoliosis in 56 patients affected by FD of bone. Fifty patients were part of a cohort reported in a multicentric study on FD promoted by European Pediatric Orthopedic Society (EPOS) in 1999, and six were new patients. There were 30 females and 26 males (mean age 12.5爕ears; range 142爕ears). Twenty-three had monostoti...

  3. Simulants of Malignant Melanoma

    Science.gov (United States)

    Pi茅rard-Franchimont, Claudine; Delvenne, Philippe

    2015-01-01

    During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further suggested such as MELTUMP (after melanocytic tumor of uncertain malignant potential) and STUMP (after Spitzoid melanocytic tumor of uncertain malignant potential). In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM) variants, are grouped under the tentative broad heading skin melanocytoma. Such set of AMN frequently follows an indolent course, although they exhibit atypical and sometimes worrisome patterns or cytological atypia. Rare cases of skin melanocytomas progress to loco regional clusters of lesions (agminate melanocytomas), and even to regional lymph nodes. At times, the distinction between a skin melanocytoma and MM remains puzzling. However, multipronged immunohistochemistry and emerging molecular biology help profiling any malignancy risk if present. PMID:26779311

  4. Simulants of Malignant Melanoma.

    Science.gov (United States)

    Pi茅rard, G茅rald E; Pi茅rard-Franchimont, Claudine; Delvenne, Philippe

    2015-02-10

    During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further suggested such as MELTUMP (after melanocytic tumor of uncertain malignant potential) and STUMP (after Spitzoid melanocytic tumor of uncertain malignant potential). In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM) variants, are grouped under the tentative broad heading skin melanocytoma. Such set of AMN frequently follows an indolent course, although they exhibit atypical and sometimes worrisome patterns or cytological atypia. Rare cases of skin melanocytomas progress to loco regional clusters of lesions (agminate melanocytomas), and even to regional lymph nodes. At times, the distinction between a skin melanocytoma and MM remains puzzling. However, multipronged immunohistochemistry and emerging molecular biology help profiling any malignancy risk if present. PMID:26779311

  5. Simulants of malignant melanoma

    Directory of Open Access Journals (Sweden)

    G茅rald E. Pi茅rard

    2015-08-01

    Full Text Available During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further suggested such as MELTUMP (after melanocytic tumor of uncertain malignant potential and STUMP (after Spitzoid melanocytic tumor of uncertain malignant potential. In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM variants, are grouped under the tentative broad heading skin melanocytoma. Such set of AMN frequently follows an indolent course, although they exhibit atypical and sometimes worrisome patterns or cytological atypia. Rare cases of skin melanocytomas progress to loco regional clusters of lesions (agminate melanocytomas, and even to regional lymph nodes. At times, the distinction between a skin melanocytoma and MM remains puzzling. However, multipronged immunohistochemistry and emerging molecular biology help profiling any malignancy risk if present.

  6. Malignant salivary gland tumours

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, S.H. (University of the Witwatersrand, Johannesburg (South Africa). Dept. of Oral Pathology)

    1982-08-01

    The most frequent malignant salivary gland tumours are the mucoepidermoid tumour, adenoid cystic carcinoma and adenocarcinoma. The major salivary glands and the minor glands of the mouth and upper respiratory tract may potentially develop any of these malignant lesions. Malignant lesions most frequently present as a palpable mass and tend to enlarge more rapidly than benign neoplasms. Pain, paresthesia, muscle paralysis and fixation to surrounding tissue are all ominous signs and symptoms. The only reliable means of differential diagnosis of these lesions is biopsy and histologic analysis. Therapy involves surgery or a combination of surgery and radiation therapy. The ultimate prognosis is governed by the intrinsic biologic behaviour of the neoplasms, the extent of disease and adequate clinical therapy.

  7. Malignant salivary gland tumours

    International Nuclear Information System (INIS)

    The most frequent malignant salivary gland tumours are the mucoepidermoid tumour, adenoid cystic carcinoma and adenocarcinoma. The major salivary glands and the minor glands of the mouth and upper respiratory tract may potentially develop any of these malignant lesions. Malignant lesions most frequently present as a palpable mass and tend to enlarge more rapidly than benign neoplasms. Pain, paresthesia, muscle paralysis and fixation to surrounding tissue are all ominous signs and symptoms. The only reliable means of differential diagnosis of these lesions is biopsy and histologic analysis. Therapy involves surgery or a combination of surgery and radiation therapy. The ultimate prognosis is governed by the intrinsic biologic behaviour of the neoplasms, the extent of disease and adequate clinical therapy

  8. [Paediatric malignant liver tumours].

    Science.gov (United States)

    Brugi鑢es, Laurence; Branchereau, Sophie; Laithier, V閞onique

    2012-02-01

    Tumours and pseudotumours of the liver are a heterogeneous group of neoplasm including 60% of malignant tumours. Malignant liver tumours account for less than 2% of the lesions in children and vary considerably in incidence throughout the paediatric age range, with hepatoblastoma, rhabdoid tumour of the liver, hemangioendothelioma, biliary tract rhabdomysosarcoma and mesenchymal hamartoma in the first two years of life and hepatocellular carcinoma, focal nodular hyperplasia, and undifferentiated sarcoma in older children and adolescents. Treatment of malignant epithelial tumours is based on the surgical resection of the tumour associated with pre- and postoperative chemotherapy including cisplatinum. Modalities of the treatment are adapted to risk factors. Survival rates at three years are over 80% for localised hepatoblastoma whereas they are less than 30% in hepatocellular carcinomas. The role of targeted therapies still has to be defined. PMID:22266074

  9. A 40-year-old gossypiboma (foreign body granuloma) mimicking a malignant femoral surface tumor

    International Nuclear Information System (INIS)

    The patient was a 61-year-old man who developed gossypiboma of the left thigh and femur resulting in the imaging appearances of a malignant surface tumor. He had a past history of surgery on the left femur for open fracture 40 years previously. Radiographs and CT showed a soft tissue mass with osteolysis and periosteal thickening of the left femur. On MRI, the mass showed heterogeneous signal intensity with contrast enhancement at the periphery, suggesting a malignancy. 99mTc-HMDP bone scintigraphy showed a faint ring-like uptake, but thallium -201 scintigraphy did not show any uptake in the tumor. An extensive intralesional excision was performed. Postoperative histopathological examination showed a fibrous foreign body with reactive changes. There were neither viable cells nor atypical giant cells around the foreign body. No malignant change was evident. Based on surgical and histopathological examinations, the tumor was finally diagnosed as gossypiboma related to a retained surgical sponge. (orig.)

  10. A 40-year-old gossypiboma (foreign body granuloma) mimicking a malignant femoral surface tumor

    Energy Technology Data Exchange (ETDEWEB)

    Sakayama, Kenshi; Fujibuchi, Taketsugu; Kidani, Teruki; Miyawaki, Joji; Yamamoto, Haruyasu [Ehime University School of Medicine, Department of Orthopaedic Surgery, Ehime (Japan); Sugawara, Yoshifumi [Ehime University School of Medicine, Department of Radiology, Ehime (Japan)

    2005-04-01

    The patient was a 61-year-old man who developed gossypiboma of the left thigh and femur resulting in the imaging appearances of a malignant surface tumor. He had a past history of surgery on the left femur for open fracture 40 years previously. Radiographs and CT showed a soft tissue mass with osteolysis and periosteal thickening of the left femur. On MRI, the mass showed heterogeneous signal intensity with contrast enhancement at the periphery, suggesting a malignancy. {sup 99m}Tc-HMDP bone scintigraphy showed a faint ring-like uptake, but thallium -201 scintigraphy did not show any uptake in the tumor. An extensive intralesional excision was performed. Postoperative histopathological examination showed a fibrous foreign body with reactive changes. There were neither viable cells nor atypical giant cells around the foreign body. No malignant change was evident. Based on surgical and histopathological examinations, the tumor was finally diagnosed as gossypiboma related to a retained surgical sponge. (orig.)

  11. Pleural spill malign

    International Nuclear Information System (INIS)

    The pleural spills are developed because of an alteration in the mechanisms that usually move between 5 and 10 liters of liquid through the space pleural every 24 hours and this is reabsorbed, only leaving 5 to 20 ml present. The causes more common of spill pleural they are: congestive heart failure, bacterial pneumonia, malign neoplasia and pulmonary clot. The causes more common of pleural spill malign in general are: cancer of the lung, cancer of the breast and lymphomas. In the man, cancer of the lung, lymphomas and gastrointestinal cancer. In the woman, cancer of the breast, gynecological cancer and lung cancer. The paper, includes their characteristics, treatments and medicines

  12. Diffuse malignant peritoneal mesothelioma.

    Science.gov (United States)

    Shih, Chih-An; Ho, Szu-Pei; Tsay, Feng-Woei; Lai, Kwok-Hung; Hsu, Ping-I

    2013-11-01

    Mesothelioma often originates in the pleura and less frequently in the peritoneum. This article describes a rare case of diffuse malignant peritoneal mesothelioma in a 54-year-old male construction worker who was admitted to our hospital with a 2-month history of progressive abdominal distention. Abdominal computed tomography revealed extensive peritoneal nodularity and omental cake along with massive ascites. Imaging findings initially suggested peritoneal carcinomatosis, primary peritoneal carcinoma, and tuberculous peritonitis. Laparoscopic biopsy of the omentum and peritoneum confirmed the diagnosis of malignant peritoneal mesothelioma of epitheloid type. Although systemic chemotherapy was administered, no tumor regression was found. The patient finally died of nosocomial infection. PMID:24183360

  13. Malignant system diseases

    International Nuclear Information System (INIS)

    Following a brief survey on the not entirely clear aetiology of the malignant system diseases, their epidemiology and histology, as well as the clinic and treatment fundamentals. The author deals with malignant lymphoma and the myeloproliferative diseases in two special sections. In the case of lymphoma he distinguishes between the treatment of Hodgkin lymphoma and non-Hodgkin lymphoma and gives a survey on the histology, various stages, performance of radiotherapy with therapy plan, as well as prognoses and results. The myeloproliferative diseases are treated according to their individual forms (acute, chronic, myeloic leukemia and chronic lymphatic leukemia, osteomyelosklerosis, polycythaemic vera, plasmocytoma and eosinophile granulom) and the corresponding form of radiotherapy. (MG)

  14. Magnetic resonance of lipomatous, fibrous and muscular tissue tumors

    International Nuclear Information System (INIS)

    Two hundred and three MR examinations were reviewed of 195 patients with lipomatous, fibrous and muscular tissues tumors which were evaluated at staging or during the follow-up. All examinations were obtained with a 1.5 T superconductive magnet, and both T1 and T2-weighted images were acquired. Its high contrast resolution, its direct multiplanarity and its allowing both T1 and T2-weighted images to be obtained are the mos important characteristics of MR imaging. In our experience, MRI demonstrated a high overall accuracy (94.8%) - 94.1% at restaging alone - with similar sensitivity both at the staging of the disease (97.5%) and during the follow-up (96%). Overall sensibility was 96.3%. MR specificity in histologically proven relapses was 86.8%. Even though it is gradually assessing itself as the most important method in the evaluation of soft tissues masses, MRI allows an histological diagnosis to be made only in lipomatous tumors and in benign fibrous tumors due to their specific signal features. The commonest though specific finding is a soft tissue mass with relatively low signal intensity in T1-weighted images. In our opinion, MR imaging is the method of choice during the follow-up of the disease, whereas it is probably a complementary technique in the staging. (author)

  15. Fibrous Fillers to Manufacture Ultra High Ash/Performance Paper

    Energy Technology Data Exchange (ETDEWEB)

    Dr. VIjay K. Mathur

    2009-04-30

    The paper industry is one of the largest users of energy and emitters of CO2 in the US manufacturing industry. In addition to that, it is facing tremendous financial pressure due to lower cost imports. The fine paper industry has shrunk from 15 million tons per year production to 10 million tons per year in the last 5 years. This has resulted in mill closures and job loses. The AF&PA and the DOE formed a program called Agenda 2020 to help in funding to develop breakthrough technologies to provide help in meeting these challenges. The objectives of this project were to optimize and scale-up Fibrous Fillers technology, ready for commercial deployment and to develop ultra high ash/high performance paper using Fibrous Fillers. The goal was to reduce energy consumption, carbon footprint, and cost of manufacturing paper and related industries. GRI International (GRI) has been able to demonstrate the techno - economic feasibility and economic advantages of using its various products in both handsheets as well as in commercial paper mills. GRI has also been able to develop sophisticated models that demonstrate the effect of combinations of GRI's fillers at multiple filler levels. GRI has also been able to develop, optimize, and successfully scale-up new products for use in commercial paper mills.

  16. A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots

    Directory of Open Access Journals (Sweden)

    Yong Yan Wang

    2011-10-01

    Full Text Available The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus. From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-尾-D-glucopyranoside and three known glycosides [1尾,6伪-dihydroxy-cis-eudesm-3-ene-6-O-尾-D-glucopyranoside (liriopeoside A, 1尾,6尾-dihydroxy-cis-eudesm-3-ene-6-O-尾-D-glucopyranoside, and 1伪,6尾-dihydroxy-5,10-bis-epi-eudesm-4(15-ene-6-O-尾 D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-尾-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC50 value of 339.76 渭g/mL, while liriopeoside A (LC50 = 82.84 渭g/mL and 1尾,6尾-dihydroxy-cis-eudesm-3-ene-6-O-尾-D-glucopyranoside (LC50 = 153.39 渭g/mL also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC50 value of 182.56 渭g/mL.

  17. Heat Transfer Modeling for Rigid High-Temperature Fibrous Insulation

    Science.gov (United States)

    Daryabeigi, Kamran; Cunnington, George R.; Knutson, Jeffrey R.

    2012-01-01

    Combined radiation and conduction heat transfer through a high-temperature, high-porosity, rigid multiple-fiber fibrous insulation was modeled using a thermal model previously used to model heat transfer in flexible single-fiber fibrous insulation. The rigid insulation studied was alumina enhanced thermal barrier (AETB) at densities between 130 and 260 kilograms per cubic meter. The model consists of using the diffusion approximation for radiation heat transfer, a semi-empirical solid conduction model, and a standard gas conduction model. The relevant parameters needed for the heat transfer model were estimated from steady-state thermal measurements in nitrogen gas at various temperatures and environmental pressures. The heat transfer modeling methodology was evaluated by comparison with standard thermal conductivity measurements, and steady-state thermal measurements in helium and carbon dioxide gases. The heat transfer model is applicable over the temperature range of 300 to 1360 K, pressure range of 0.133 to 101.3 x 10(exp 3) Pa, and over the insulation density range of 130 to 260 kilograms per cubic meter in various gaseous environments.

  18. Low level hydrogen peroxide generation from a nonwoven fibrous pectin-cellulose blend

    Science.gov (United States)

    Fibrous pectic-cellulose (FPC) (cellulose blended with primary cell wall pectin at 2 percent by weight of pectin) is product made from naturally occurring plant fibers. FPC is a fibrous mixture of polysaccharides with a low percent by weight of pectin-based primary cell wall and lipid components att...

  19. High-surface-area silica nanospheres (KCC-1) with a fibrous morphology

    KAUST Repository

    Polshettiwar, Vivek

    2010-08-02

    Fibrous nanosilica: A new family of high-surface-area silica nanospheres (KCC-1) have been prepared (see picture). KCC-1 features excellent physical properties, including high surface area, unprecedented fibrous surface morphology, high thermal (up to 950 掳C) and hydrothermal stabilities, and high mechanical stability. Copyright 漏 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Malignant tumors of childhood

    International Nuclear Information System (INIS)

    This book contains 34 papers about malignant tumors. some of the titles are: Invasive Cogenital Mesoblastic Nephroma, Leukemia Update, Unusual Perinatal Neoplasms, Lymphoma Update, Gonadal Germ Cell Tumors in Children, Nutritional Status and Cancer of Childhood, and Chemotherapy of Brain tumors in Children

  1. Malignant melanoma - cutaneous metastases

    OpenAIRE

    Padmavathy L; Rao L; Ethirajan N; Swamy B

    2008-01-01

    Melanoma composed of melanocytes may arise in the skin or other tissues harboring melanocytes, such muco-cutaneous junctions, mucosa including the conjunctiva, iris, choroids and substantia nigra.1 Metastases to the skin and subcutaneous tissues from a malignant melanoma are less common. A case of multiple painless nodules on the body that revealed metastatic deposits of melanoma on histopathological examination is being reported.

  2. Primary malignant intramedullary lymphoma

    International Nuclear Information System (INIS)

    A case of primary malignant intramedullary lymphoma, localized in the dorsal part of the spinal cord is presented. The clinical symptoms were associated with motor and sensitive deficit. Clinical investigations excluded the presence of lymphoma in other locations in the central nervous system and the extra neural organs. Postoperative radiotherapy and chemotherapy improved relict neurological symptoms. (authors)

  3. Transarticular invasion of the sacroiliac joints by malignant pelvic bone tumors

    International Nuclear Information System (INIS)

    To describe modes of transarticular invasion, with reference to the size and location of a tumor, the anatomic characteristics of invaded cartilage,and the existence of ankylosis in SI joint. Eleven histologically confirmed malignant pelvic bone tumors involving transarticular invasion of sacroiliac joints, were retrospectively analysed. Transarticular invasion of a joint was defined as involvement of its opposing bones. The anatomic site and size of the tumors were analysed, and invaded sacroiliac joint was divided into upper, middle and lower parts on the basis of the anatomic characteristics of the intervening cartilage: synovial hyaline or fibrous ligamentous. the existence of ankylosis was determined, and transarticular invasion directly across a joint was classified as direct invasion. Extension of tumors around a joint from its periphery to the opposing bone were considered as indirect invasion. All tumors were located near the sacroiliac joint, eight at the ilium and three at the sacrum. Six invasions were indirect and five were direct. Average tumor area was larger in indirect cases than in direct: 191.8 cm2 vs. 69.6 cm2. In all indirect invasions, a huge soft tissue mass abutted onto the peripheral portion of the sacroiliac joint. In five of six cases of indirect transarticular invasion, the upper part of the joint posteriorly located fibrous ligamentous cartilage. In the other, the lower part was invaded, and this involved a detour around the joint space, avoiding the invasion of intervening cartilage. Ankylosis occurred in one of the indirect cases. Among the five cases of direct invasion, there was invasion of the posteriorly located ligamentous fibrous cartilage in three without ankylosis. In the other two cases, involving ankylosis, the synovial hyaline cartilage was invaded directly at the lower part of the joint. Transarticular invasions of sacroiliac joint via fibrous cartilage are most common. Ankylosis of the sacroiliac joint facilitates hyaline cartilage invasion. We consider that in transarticular invasion of malignant pelvic bone tumors, indirect invasion is more common than direct

  4. Fabrication and EM shielding properties of electrospining PANi/MWCNT/PEO fibrous membrane and its composite

    Science.gov (United States)

    Zhang, Zhichun; Jiang, Xueyong; Liu, Yanju; Leng, Jinsong

    2012-04-01

    In this paper, Polyaniline-based fibrous membranes were fabricated with multi-walled carbon nanotubes and polyethylene oxide (PEO) by the electrospinning method. And then PANi/PEO/MWCNT fibrous membranes reinforced epoxy based nanocomposite was then fabricated. The morphology and electrical properties of PANi /MWCNT /PEO fibrous membrane was characterized by scanning electron microscope (SEM). The morphologies of the membranes indicate that the electrospining method can fabricate well nano structures fibrous membrane. The EM properties of the composite reinforced with the electrospining fibrous membrane were measured by vector network analyzer. The results show that the permittivity real, image parts and permeability real part of the composite increase by filling with PANI/PEO and PANI/CNT/PEO membrane. The EM shielding and absorb performance is base on the dielectric dissipation. And different membranes made of different materials show different EM parameter, and different EM shielding performance, which can be used to the EM shielding and stealth material design and fabrication.

  5. Fibrous scar in the infrapatellar fat pad after arthroscopy. MR imaging

    International Nuclear Information System (INIS)

    We describe the MR appearance of fibrous scars in the infrapatellar fat pad after arthroscopy. The subjects were 96 patients who underwent arthroscope-assisted anterior cruciate ligament (ACL) reconstruction and were examined by oblique sagittal MR imaging at different follow-up intervals. Two observers evaluated the characteristics of the fibrous scars in the infrapatellar fat pad. All fibrous scars with low signal intensity were accentuated at the portal and coursed horizontally through the infrapatellar fat pad. The fibrous scar within the fat pad occurred and peaked within 6 months after arthroscopy. It then subsided gradually and had disappeared by one year later in nearly half of the patients. Identifying MR imaging characteristics of fibrous scars in the fat pad after arthroscopy may be clinically helpful to differentiate these scars from other abnormalities that involve the infrapatellar fat pad. (author)

  6. Fibrous scar in the infrapatellar fat pad after arthroscopy. MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Guangyu; Niitsu, Mamoru; Ikeda, Kotaro; Itai, Yuji [Tsukuba Univ., Ibaraki (Japan). Inst. of Clinical Medicine; Endo, Hideho

    2000-02-01

    We describe the MR appearance of fibrous scars in the infrapatellar fat pad after arthroscopy. The subjects were 96 patients who underwent arthroscope-assisted anterior cruciate ligament (ACL) reconstruction and were examined by oblique sagittal MR imaging at different follow-up intervals. Two observers evaluated the characteristics of the fibrous scars in the infrapatellar fat pad. All fibrous scars with low signal intensity were accentuated at the portal and coursed horizontally through the infrapatellar fat pad. The fibrous scar within the fat pad occurred and peaked within 6 months after arthroscopy. It then subsided gradually and had disappeared by one year later in nearly half of the patients. Identifying MR imaging characteristics of fibrous scars in the fat pad after arthroscopy may be clinically helpful to differentiate these scars from other abnormalities that involve the infrapatellar fat pad. (author)

  7. Malignant Melanoma of the Foot

    Science.gov (United States)

    ... Text Size Print Bookmark Malignant Melanoma of the Foot What is Malignant Melanoma? Melanoma is a cancer ... age groups, even the young. Melanoma in the Foot Melanoma that occurs in the foot or ankle ...

  8. Image diagnosis of malignant mesothelioma

    International Nuclear Information System (INIS)

    3 cases of malignant mesothelioma confirmed by pathological examination were reported. CT showed solid mass with moderate enhancement by contrast medium. CT appears to be a very useful tool to make a diagnosis of malignant mesothelioma. (author)

  9. Microstructure and properties of nano-fibrous PCL-b-PLLA scaffolds for cartilage tissue engineering

    Directory of Open Access Journals (Sweden)

    L He

    2009-10-01

    Full Text Available Nano-fibrous scaffolds which could potentially mimic the architecture of extracellular matrix (ECM have been considered a good candidate matrix for cell delivery in tissue engineering applications. In the present study, a semicrystalline diblock copolymer, poly(e-caprolactone-block-poly(L-lactide (PCL-b-PLLA, was synthesized and utilized to fabricate nano-fibrous scaffolds via a thermally induced phase separation process. Uniform nano-fibrous networks were created by quenching a PCL-b-PLLA/THF homogenous solution to -20潞C or below, followed by further gelation for 2 hours due to the presence of PLLA and PCL microcrystals. However, knot-like structures as well as continuously smooth pellicles appeared among the nano-fibrous network with increasing gelation temperature. DSC analysis indicated that the crystallization of PCL segments was interrupted by rigid PLLA segments, resulting in an amorphous phase at high gelation temperatures. Combining TIPS (thermally induced phase separation with salt-leaching methods, nano-fibrous architecture and interconnected pore structures (144卤36 mm in diameter with a high porosity were created for in vitro culture of chondrocytes. Specific surface area and protein adsorption on the surface of the nano-fibrous scaffold were three times higher than on the surface of the solid-walled scaffold. Chondrocytes cultured on the nano-fibrous scaffold exhibited a spherical condrocyte-like phenotype and secreted more cartilage-like extracellular matrix (ECM than those cultured on the solid-walled scaffold. Moreover, the protein and DNA contents of cells cultured on the nano-fibrous scaffold were 1.2-1.4 times higher than those on the solid-walled scaffold. Higher expression levels of collagen II and aggrecan mRNA were induced on the nano-fibrous scaffold compared to on the solid-walled scaffold. These findings demonstrated that scaffolds with a nano-fibrous architecture could serve as superior scaffolds for cartilage tissue engineering.

  10. EXTRA PLEURAL SOLITARY FIBROUS TUMOR: A REPORT OF TWO CASES

    Directory of Open Access Journals (Sweden)

    Meenakumari

    2014-12-01

    Full Text Available : Solitary fibrous tumor (SFT belongs to a group of mesenchymal tumors, first described as a primary spindle cell tumor of the pleura in 1931. Recently, SFT has been reported in various locations with no relation to serosal surface. We describe two such cases in unusual sites of orbit and nasal cavity. Histopathologically, the tumors had a disorganized or 鈥減atternless鈥 arrangement of spindle cells in a collagenous background and prominent vascular channels of varying sizes. Immunohistochemically both tumours showed CD 34 positivity. The two patients had benign clinical course with limited follow-up. SFT should be included in the differential diagnosis of spindle cell tumors arising in the nasal cavity and orbit.

  11. A theoretical analysis of local thermal equilibrium in fibrous materials

    Directory of Open Access Journals (Sweden)

    Tian Mingwei

    2015-01-01

    Full Text Available The internal heat exchange between each phase and the Local Thermal Equilibrium (LTE scenarios in multi-phase fibrous materials are considered in this paper. Based on the two-phase heat transfer model, a criterion is proposed to evaluate the LTE condition, using derived characteristic parameters. Furthermore, the LTE situations in isothermal/adiabatic boundary cases with two different heat sources (constant heat flux and constant temperature are assessed as special transient cases to test the proposed criterion system, and the influence of such different cases on their LTE status are elucidated. In addition, it is demonstrated that even the convective boundary problems can be generally estimated using this approach. Finally, effects on LTE of the material properties (thermal conductivity, volumetric heat capacity of each phase, sample porosity and pore hydraulic radius are investigated, illustrated and discussed in our study.

  12. Fibrous synovial sarcoma of the foot - a case report

    International Nuclear Information System (INIS)

    The authors report a case of a 24 year-old female patient with a three-month history of pain and enlargement of the left hallux. Ultrasound showed a heterogeneous, hypoechoic solid soft tissue mass with cystic areas and calcification in the dorsum of the left hallux. A tendinous structure was identified within the lesion but no evidence of involvement of adjacent osseous structures was found. Doppler ultrasound revealed central and peripheral hypervascularization of the lesion. Magnetic resonance imaging demonstrated a solid soft tissue mass containing a tendinous structure. The lesion appeared as an intermediate signal intensity structure on T1 images, high signal intensity on T2 images, and showed marked enhancement after intravenous administration of gadolinium. No osseous lesions were identified. The patient was submitted to surgical resection of the lesion in the dorsum of the left hallux and the pathology results revealed a monophasic fibrous synovial sarcoma. (author)

  13. Polyelectrolyte-complex nanostructured fibrous scaffolds for tissue engineering

    International Nuclear Information System (INIS)

    In the current work, polyelectrolyte complex (PEC) fibrous scaffolds for tissue engineering have been synthesized and a mechanism of their formation has been investigated. The scaffolds are synthesized using polygalacturonic acid and chitosan using the freeze drying methodology. Highly interconnected pores of sizes in the range of 5-20 渭m are observed in the scaffolds. The thickness of the fibers was found to be in the range of 1-2 渭m. Individual fibers have a nanogranular structure as observed using AFM imaging. In these scaffolds, PEC nanoparticles assemble together at the interface of ice crystals during freeze drying process. Further investigation shows that the freezing temperature and concentration have a remarkable effect on structure of scaffolds. Biocompatibility studies show that scaffold containing chitosan, polygalacturonic acid and hydroxyapatite promotes cell adhesion and proliferation. On the other hand, cells on scaffolds fabricated without hydroxyapatite nanoparticles showed poor adhesion.

  14. Hyperostotic esthesioneuroblasma: Rare variant and fibrous dysplasia mimicker

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, Manzoor [Neuroradiology Section, Imaging Institute, Cleveland Clinic Foundation, Cleveland (United States); Knott, Phillip Daniel [Director of Facial Plastic and Reconstructive Surgery, Associate Professor of Otolaryngology, UCSF School of Medicine, San Fransisco (United States)

    2014-02-15

    A 65-year-old male presented with a 3-year history of orbital symptoms. An imaging-based diagnosis of fibrous dysplasia involving the skull base was made at another institution. CT showed a diffuse sinonasal mass and ground-glass appearance of the bones of the anterior skull base with bony defects and mucocele formation. MRI demonstrated an accompanying intracranial and orbital rind of soft tissue mass along the hyperostotic bones. FDG-PET showed corresponding intense hypermetabolism. Small cysts were observed at the tumor-brain interface. Biopsy revealed esthesioneuroblastoma with bone infiltration that is compatible with the hyperostotic variant of esthesioneuroblastoma. There are a few cases of hyperostotic esthesioneuroblastoma reported in the literature.

  15. The Fibrous Form Confers Unique Properties on Materials

    Directory of Open Access Journals (Sweden)

    Stephen C. Bondy

    2014-08-01

    Full Text Available The main distinguishing feature of the fiber is simply that it is a particle where the ratio of length to width ratio is very large. This provides connectivity between two relatively remote areas. Such linkage may confer strength through physical linkage or may relate primarily to information transfer. In the inorganic world, fibers can originate as a result of the process by which the solid material is condensed from the corresponding liquid form. Man-made fibrous materials are essentially polymers of a single or several molecular species repeated many times, or, in the case of metals, chains of elemental atoms. A host of man-made fibers have been developed in the last 50 years. A large range of uses has been found for these products. These include clothing, upholstery, fiber optic cables, filters, insulation, electromagnetic screening, and boat and aircraft construction. [...

  16. Determination of physical properties of fibrous thermal insulation

    Directory of Open Access Journals (Sweden)

    Jeandel G.

    2012-10-01

    Full Text Available The objective of this study is to characterize both experimentally and theoretically, conductive and radiative heat transfer within polyester batting. This material is derived from recycled bottles (PET with fibres of constant diameters. Two other mineral and plant fibrous insulation materials, (glass wool and hemp wool are also characterized for comparative purposes. To determine the overall thermophysical properties of the tested materials, heat flux measurement are carried out using a device developed in house. The radiative properties of the material are determined by an inverse method based on measurements of transmittance and reflectance using a FTIR spectrometer and by solving the equation of radiative heat transfer. These measures are compared to results of numerical simulations.

  17. Alumina composites for oxide/oxide fibrous monoliths

    International Nuclear Information System (INIS)

    Most work on ceramic fibrous monoliths (FMs) has focused on the Si3N4/BN system. In an effort to develop oxidation-resistant FMs, several oxide systems have recently been examined. Zirconia-toughened alumina and alumina/mullite appear to be good candidates for the cell phase of FMs. These composites offer higher strength and toughness than pure alumina and good high-temperature stability. By combining these oxides, possibly with a weaker high-temperature oxide as the cell-boundary phase, it should be possible to product a strong, resilient FM that exhibits graceful failure. Several material combinations have been examined. Results on FM fabrication and microstructural development are presented

  18. Diffuse malignant pleural mesothelioma in an urban hospital: Clinical spectrum and trend in incidence over time

    International Nuclear Information System (INIS)

    This retrospective analysis reviews the clinical experience of a major urban referral hospital with diffuse malignant pleural mesothelioma during the 14-year period from 1973 through 1986. Seventy-five cases of definite or equivocal mesothelioma were identified. There were four cases of primary malignant peritoneal mesothelioma, seven cases of benign fibrous mesothelioma, and 64 cases of diffuse malignant pleural mesothelioma. In 43 cases (67%) of diffuse malignant pleural mesothelioma, there was historic evidence of asbestos exposure. In 21 cases (33%), there was no known history of asbestos exposure. An increase in annual incidence of diffuse malignant pleural mesothelioma was observed over the study period, from three cases in 1973 to ten cases in 1986. Despite greater awareness of this disease, the diagnosis remains a difficult one to establish given the nonspecific symptoms, signs and radiographic appearance, variable histologic appearance, and poor diagnostic sensitivity and specificity of thoracentesis and closed pleural biopsy. Thoracotomy, thoracoscopy, and CT-guided needle biopsies gave higher yields and are the diagnostic measures of choice when diffuse malignant pleural mesothelioma is suspected

  19. Diffuse malignant pleural mesothelioma in an urban hospital: Clinical spectrum and trend in incidence over time

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, K.E.; Oliver, L.C.; Kazemi, H. (Massachusetts General Hospital, Boston (USA))

    1989-01-01

    This retrospective analysis reviews the clinical experience of a major urban referral hospital with diffuse malignant pleural mesothelioma during the 14-year period from 1973 through 1986. Seventy-five cases of definite or equivocal mesothelioma were identified. There were four cases of primary malignant peritoneal mesothelioma, seven cases of benign fibrous mesothelioma, and 64 cases of diffuse malignant pleural mesothelioma. In 43 cases (67%) of diffuse malignant pleural mesothelioma, there was historic evidence of asbestos exposure. In 21 cases (33%), there was no known history of asbestos exposure. An increase in annual incidence of diffuse malignant pleural mesothelioma was observed over the study period, from three cases in 1973 to ten cases in 1986. Despite greater awareness of this disease, the diagnosis remains a difficult one to establish given the nonspecific symptoms, signs and radiographic appearance, variable histologic appearance, and poor diagnostic sensitivity and specificity of thoracentesis and closed pleural biopsy. Thoracotomy, thoracoscopy, and CT-guided needle biopsies gave higher yields and are the diagnostic measures of choice when diffuse malignant pleural mesothelioma is suspected.

  20. Seven inflammatory pseudotumors in a girl and six boys

    International Nuclear Information System (INIS)

    This is a retrospective study of a girl and six boys aged 5-15.5 years (mean, 10.7 years) with benign inflammatory pseudotumors involving the lung, stomach, abdomen, mesentery, retroperitoneum, and testis. All but one of the tumors were resected. Recurrence in one case prompted secondary resection. One child died of secondary aortic bleeding; the others are fine. The tumors are characterized by proliferative fibrovascular tissue and inflammatory cells. Histiocytes, plasma cells, or sclerotic elements may predominate. Tumor etiology is unknown. Differentiation from malignant fibrous histiocytoma may be difficult pathologically, and differentiation from a malignant tumor (e.g., lymphoma, neuroblastoma) or an abscess may be difficult radiologically

  1. Uncommon breast lesions. Radiologic and pathologic findings

    International Nuclear Information System (INIS)

    To illustrate the radiologic findings in several uncommon breast and infrequent diseases that present with unusual mammographic images. We reviewed the mammograms performed in our department between 1998 and 1995, selecting 16 patients (12 women and 4 men). Nine patients had benign breast lesions (adenomyoepithelioma, epidermal cyst, adenoid cystic carcinoma, myofibroblastoma, multiple hamartomas, intra cystic papillomas, lipoma, idiopathic granulomatous mastitis and fat necrosis) and 7 patients presented malignant breast diseases (malignant fibrous histiocytoma, intra cystic carcinoma, primary lymphoma of the breast, liposarcoma and metastasis). We present a review of the radiologic and pathologic findings in several uncommon breast diseases. (Author) 14 refs

  2. Myositis Ossificans Mimicking Sarcoma, the Importance of Diagnostic Imaging 鈥 Case Report

    International Nuclear Information System (INIS)

    Myositis ossificans is localized inflammatory process affecting skeletal muscles. Very rarely it can affect one of the neck muscles and present as a neck tumor, it can be misdiagnosed as the clinical, radiological and histological examinations can mimic a sarcoma. We report a 29 year old female patient with neck tumor suspected to be a sarcoma who underwent full diagnostics imaging and open bipsy with histopatological examination, afterwards surgical excision was performed. The aim of this study was to present the differential diagnosis based on diagnostics imaging between MO and malignant tumors, such as parosteal sarcoma, synovial sarcoma and malignant fibrous histiocytoma

  3. Post-radiation soft tissue sarcoma

    International Nuclear Information System (INIS)

    Seven patients received radiation for malignancies, and two received for benign tumors. The latency period from radiation to symptom ranged from two years to 36 years (mean 17.2 years). Post-radiation soft tissue sarcomas (PRS) comprised six cases of malignant fibrous histiocytomas, two leiomyosarcomas, and one angiosarcoma. The five-year survival of PRS was 16.7% showing a worse prognosis than spontaneously occurring soft tissue sarcomas. Seven PRS occurred superficially, and two were deeply located. Four cases occurring in the superficial tissues had histories of radiation-induced dermatitis. The radiation-induced dermatitis was suggested to be a risk factor for development of PRS. (author)

  4. Malignant peritoneal mesothelioma

    International Nuclear Information System (INIS)

    Spread of cancer cells of the peritoneal surface was previously associated with the impossibility of curative therapy and short-term survival. Scientific and pharmacological studies have shown that prevention and effective treatment are now a reality. Diffuse malignant peritoneal mesothelioma is the rarest and dangerous abdominal malignancy. The author points to modest results in the systemic treatment contrasts with the modern multimodal approach, which extended the survival of patients. The treatment consists of cytoreductive surgery (CRS) including peritonectomy (PE) and the perioperative application of the combination of cytotoxic agents in hyperthermia (HIPEC). Currently there are studies that show an acceptable mortality, morbidity and profits, including long-term survival in a group of patients with ineffective or exhausted conventional oncological treatment. (author)

  5. Hyaluronan in human malignancies

    International Nuclear Information System (INIS)

    Hyaluronan, a major macropolysaccharide in the extracellular matrix of connective tissues, is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of various human tumors and modulates intracellular signaling pathways, cell proliferation, motility and invasive properties of malignant cells. Experimental and clinicopathological evidence highlights the importance of hyaluronan in tumor growth and metastasis. A high stromal hyaluronan content is associated with poorly differentiated tumors and aggressive clinical behavior in human adenocarcinomas. Instead, the squamous cell carcinomas and malignant melanomas tend to have a reduced hyaluronan content. In addition to the stroma-cancer cell interaction, hyaluronan can influence stromal cell recruitment, tumor angiogenesis and epithelial-mesenchymal transition. Hyaluronan receptors, hyaluronan synthases and hyaluronan degrading enzymes, hyaluronidases, are involved in the modulation of cancer progression, depending on the tumor type. Furthermore, intracellular signaling and angiogenesis are affected by the degradation products of hyaluronan. Hyaluronan has also therapeutic implications since it is involved in multidrug resistance.

  6. Malignant Hypertension: Ocular Manifestations

    OpenAIRE

    Silvia Mu帽oz; Nieves Mart铆n; Jorge Arruga

    2006-01-01

    Malignant hypertension may be the first manifestation of systemic hypertension. We report a clinical case of a Caucasian 41-year-old man with no previous history of blood hypertension seen at casualty because of blurred vision. Fundus examination disclosed optic disk swelling, retinal hemorrhages and infarcts. The blood pressure was 220/130 mmHg. After the appropriate management of hypertension, optic disk and retinal edema resolved, leaving minor changes as mild optic disk pallor and hard ex...

  7. Sunburn and malignant melanoma.

    OpenAIRE

    Green, A.; Siskind, V.; C. Bain; Alexander, J.

    1985-01-01

    We investigated the relationship between cutaneous malignant melanoma and multiple sunburns in the Queensland population. Interview data were gathered from 236 case-control pairs concerning their lifetime experience of severe sunburns, their occupational and recreational sun exposure, and their skin type. Excluding the lentigo maligna melanoma subtype, an association between multiple sunburns and melanoma was evident. After controlling for other major risk factors there was a significant dose...

  8. Microbiome and Malignancy

    OpenAIRE

    Plottel, Claudia S.; Blaser, Martin J.

    2011-01-01

    Current knowledge is insufficient to explain why only a proportion of individuals exposed to environmental carcinogens or carrying a genetic predisposition to cancer develop disease. Clearly, other factors must be important and one such element that has recently received attention is the human microbiome, the residential microbes including Bacteria, Archaea, Eukaryotes, and viruses that colonize humans. Here, we review principles and paradigms of microbiome-related malignancy, as illustrated ...

  9. Acquired hemophilia in malignancy.

    Science.gov (United States)

    Reeves, Brandi N; Key, Nigel S

    2012-04-01

    Acquired hemophilia is a rare but potentially morbid complication in patients with cancer. It may be seen in patients with hematologic neoplasms (usually lymphoproliferative disorders) or with solid tumors. Although the presence of an underlying malignancy portends a worse outcome, the literature suggests that the usual principles of treatment, including immunosuppression, apply to these patients. However, appropriate consideration should be given to the choice of agents, depending on individual risk factors for complications such as thrombosis and infection. PMID:22682137

  10. Intravascular malignant lymphomatosis

    International Nuclear Information System (INIS)

    Intravascular malignant lymphomatosis is a rare and probably often overlooked disease characterised by massive intravascular proliferation of lymphoid cells, usually with a poor prognosis. CT and MRI appearances are nonspecific; the most suggestive finding being both asymmetrical, bilateral, contrast enhancing high-signal areas on T2 weighting and infarct-like lesions of the cortex and basal ganglia. We report two patients with previously unreported dural and spinal cord involvement. (orig.)

  11. Malignant systemic mastocytosis.

    OpenAIRE

    Abraham E; Augustine J; Amma S; Nair K

    1992-01-01

    Malignant Systemic Mastocytosis is a very rare condition. Only about less than 40 well documented cases have been reported as per the available literature. The paper presents the case report of a 54 year old male patient who presented with huge hepatosplenomegaly and abdominal lymphadenopathy. Splenectomy specimen was 17 x 16 x 10 cm size with cut surface studded with numerous tiny 1-2 mm nodules. Histologic sections of spleen showed extensive mast cell (typical and atypical) infiltrates. Liv...

  12. Malignant melanoma - cutaneous metastases

    Directory of Open Access Journals (Sweden)

    Padmavathy L

    2008-01-01

    Full Text Available Melanoma composed of melanocytes may arise in the skin or other tissues harboring melanocytes, such muco-cutaneous junctions, mucosa including the conjunctiva, iris, choroids and substantia nigra. Metastases to the skin and subcutaneous tissues from a malignant melanoma are less common. A case of multiple painless nodules on the body that revealed metastatic deposits of melanoma on histopathological examination is being reported.

  13. Malignant melanoma - cutaneous metastases.

    Science.gov (United States)

    L, Padmavathy; L, Lakshmana Rao; N, Ethirajan; B, Krishna Swamy

    2008-01-01

    Melanoma composed of melanocytes may arise in the skin or other tissues harboring melanocytes, such muco-cutaneous junctions, mucosa including the conjunctiva, iris, choroids and substantia nigra.1 Metastases to the skin and subcutaneous tissues from a malignant melanoma are less common. A case of multiple painless nodules on the body that revealed metastatic deposits of melanoma on histopathological examination is being reported. PMID:19882041

  14. Malignant melanoma of choroid

    Directory of Open Access Journals (Sweden)

    Manohar S

    1991-01-01

    Full Text Available Four cases of malignant melanoma of the choroid are reported due to rarity of the condition in India. One of the cases presented with Naevus of Ota. All the cases had typical clinical and investigative features. All cases were enucleated. Histopathologically three of them were of mixed type and one was of the epithelioid type. Two of the cases were seen in patients below 40 years of age.

  15. Asbestos-related malignancy

    Energy Technology Data Exchange (ETDEWEB)

    Talcott, J.A.; Antman, K.H.

    1988-05-01

    Asbestos-associated malignancies have received significant attention in the lay and medical literature because of the increasing frequency of two asbestos-associated tumors, lung carcinoma and mesothelioma; the wide distribution of asbestos; its status as a prototype environmental carcinogen; and the many recent legal compensation proceedings, for which medical testimony has been required. The understanding of asbestos-associated carcinogenesis has increased through study of animal models, human epidemiology, and, recently, the application of modern molecular biological techniques. However, the detailed mechanisms of carcinogenesis remain unknown. A wide variety of malignancies have been associated with asbestos, although the strongest evidence for a causal association is confined to lung cancer and mesothelioma. Epidemiological studies have provided evidence that both the type of asbestos fiber and the industry in which the exposure occurs may affect the rates of asbestos-associated cancers. It has been shown that asbestos exerts a carcinogenic effect independent of exposure to cigarette smoking that, for lung cancers, is synergistically enhanced by smoking. Other questions remain controversial, such as whether pulmonary fibrosis necessarily precedes asbestos-associated lung cancer and whether some threshold level of exposure to asbestos (including low-dose exposures that may occur in asbestos-associated public buildings) may be safe. Mesothelioma, the most closely asbestos-associated malignancy, has a dismal natural history and has been highly resistant to therapy. However, investigational multi-modality therapy may offer benefit to some patients. 179 references.

  16. Endometriosis-associated Malignancy

    Science.gov (United States)

    Krawczyk, N.; Banys-Paluchowski, M.; Schmidt, D.; Ulrich, U.; Fehm, T.

    2016-01-01

    Endometriosis is a common condition in women of reproductive age. According to several epidemiological studies endometriosis may be associated with increased risk of various malignancies. However, endometriosis-associated malignancy (EAM) is defined by certain histological criteria. About 80鈥% of EAM have been found in the ovary, whereas 20鈥% are localized in extragonadal sites like intestine, rectovaginal septum, abdominal wall, pleura and others. Some authors suggest that EAM arise from atypical endometriosis as an intermediate lesion between endometriosis and cancer. Moreover, a number of genetic alterations, like loss of heterozygosity (LOH), PTEN, ARID1鈥夾 and p53 mutations have been found in both endometriosis and EAM. Endometriosis-associated ovarian cancer (EAOC) is mostly a well or intermediately differentiated tumor of endometrioid or clear cell histological sub-type. Women affected by EAOC are on average five to ten years younger than non-EAOC patients; in most of the cases EAOC is a low stage disease with favorable clinical outcome. Since EAM is a rare condition systematic data on EAM are still missing. A systematic retrospective study on endometriosis-associated malignancies (EAM study) is currently being conducted by the Endometriosis Research Foundation together with the study groups on ovarian and uterine tumors of the working group for gynecological oncology (AGO) (gyn@mlk-berlin.de). PMID:26941451

  17. Malignant intraocular tumors

    International Nuclear Information System (INIS)

    The role of the radiation therapist in the management of malignant intraocular tumors is changing. With more active identification of malignant intraocular tumors, and a better recognization of the manner in which one can deal with problems of radiation sensitivity, radiation techniques of all sorts will be more actively employed in the treatment of these tumors. Special techniques must be selected for appropriate circumstances of management in order to diminish to an absolute minimum the impact upon the lens, the impact upon visual acuity and the impact upon the cornea. Cobalt-60 plaques are being used more commonly in the treatment of melanomas of the choroid, and the role for radiation therapy in the management of retinoblastoma is changing markably to where it may be used as the primary treatment program rather than enucleation. In metastatic disease involving the uveal tract, radiation therapy has assumed the most important role for management. Chemotherapy should be considered as an active adjuvant in the management of not only those individuals with retinoblastoma but also in those identified circumstances where metastases to the uveal tract are being treated. The role for chemotherapy or immunotherapy in malignant melanoma is unclear

  18. Radioimmunotherapy of malignant gliomas

    International Nuclear Information System (INIS)

    Despite all technical advances (intraoperative resection control, fluorescence guided resection, advances in external beam radiation techniques) and new consolidated findings on systemic chemotherapy treatment of malignant gliomas with conventional therapeutic modalities (surgery, radiation therapy and chemotherapy) is still highly unfavourable. Total tumor erradication is impossible due to tumor infiltrations into the normal brain and the limitations given by the limited tolerance of surrounding brain tissue. New treatment strategies, therefore, aim for a more selective destruction of tumor cells. Malignant glioma cells selectively express several antigens or receptors which are not or only to a minor extent present in normal brain tissue. Administration of radiolabelled monoclonal antibodies, especially when given locoregionally, targeting these tumor-specific antigens offers an innovative therapeutic strategy that has recently demonstrated encouraging antitumor effects and acceptable toxicity in many phase I/II clinical trials. This review offers a comprehensive summary of own experiences and results of clinical trials reported in the literature dealing with radioimmunotherapy of malignant glioma and highlights future plans to further develop this therapeutic strategy. (orig.)

  19. Classification of malignant lymphomas

    International Nuclear Information System (INIS)

    Malignant lymphomas, primary tumors of the lymphoid tissues, were first described in 1832 by Thomas Hodgkin. The histological characteristics were later defined by Sternberg and Reed, and Virchow introduced the concept of lymphosarcoma in 1863. Today, these pathologies are grouped together under the synonymous terms hematosarcoma or malignant lymphoma, which are in turn divided into Hodgkin's disease (HD) and non-Hodgkin's malignant lymphomas (NHL). The therapy of lymphomas is controversial. The validity of treatment for asymptomatic patients is questioned, owing to the indolent course of many lymphomas. Results for histologically unfavorable forms are highly disparate. Exclusive radiotherapy has occasionally produced up to 78% disease-free survival at 5 years for truly localized stages. Today, however, use of chemotherapy/radiotherapy combinations is almost universal, with chemotherapy occasionally being used alone and providing 90% disease-free survival at 5 years. Chemotherapy is the main treatment for disseminated forms; the major associations include doxorubicin hydrochloride (Adriamycin), cyclophosphamide, vincristine sulfate, methotrexate, and prednisone. Radiotherapy is used more for adjuvant purposes. Synthesis of recent studies allows us to reasonably expect 40% relapse-free survival at 10 years and the establishment of a cure plateau in the near future

  20. Creation of Hybrid Nanorods From Sequences of Natural Trimeric Fibrous Proteins Using the Fibritin Trimerization Motif

    Science.gov (United States)

    Papanikolopoulou, Katerina; van Raaij, Mark J.; Mitraki, Anna

    Stable, artificial fibrous proteins that can be functionalized open new avenues in fields such as bionanomaterials design and fiber engineering. An important source of inspiration for the creation of such proteins are natural fibrous proteins such as collagen, elastin, insect silks, and fibers from phages and viruses. The fibrous parts of this last class of proteins usually adopt trimeric, ?-stranded structural folds and are appended to globular, receptor-binding domains. It has been recently shown that the globular domains are essential for correct folding and trimerization and can be successfully substituted by a very small (27-amino acid) trimerization motif from phage T4 fibritin. The hybrid proteins are correctly folded nanorods that can withstand extreme conditions. When the fibrous part derives from the adenovirus fiber shaft, different tissue-targeting specificities can be engineered into the hybrid proteins, which therefore can be used as gene therapy vectors. The integration of such stable nanorods in devices is also a big challenge in the field of biomechanical design. The fibritin foldon domain is a versatile trimerization motif and can be combined with a variety of fibrous motifs, such as coiled-coil, collagenous, and triple ?-stranded motifs, provided the appropriate linkers are used. The combination of different motifs within the same fibrous molecule to create stable rods with multiple functions can even be envisioned. We provide a comprehensive overview of the experimental procedures used for designing, creating, and characterizing hybrid fibrous nanorods using the fibritin trimerization motif.

  1. GNAS mutational analysis in differentiating fibrous dysplasia and ossifying fibroma of the jaw.

    Science.gov (United States)

    Shi, Rui-Rui; Li, Xue-Fen; Zhang, Ran; Chen, Yan; Li, Tie-Jun

    2013-08-01

    Differential diagnosis of fibrous dysplasia and ossifying fibroma may often pose problems for pathologists. The purpose of this study was to evaluate the value of mutational analysis of the GNAS gene in differentiating these two conditions. DNA samples from patients with fibrous dysplasia (n=30) and ossifying fibroma (n=21) were collected to analyze the presence of GNAS mutations at exons 8 and 9, the two previously reported hotspot regions, using polymerase chain reaction and direct sequencing. In all, 90% (27/30) of cases with fibrous dysplasia showed missense mutations of codon 201 at exon 8, with a predilection of arginine-to-histidine substitution (p.R201H, 70%) as opposed to arginine-to-cysteine substitution (p.R201C, 30%), whereas no mutation was detected at exon 9. No mutation was found in all 21 cases with ossifying fibroma. In addition, a meta-analysis of previously published reports on GNAS mutations in fibrous dysplasia and ossifying fibroma was performed to substantiate our findings. A total of 24 reports including 307 cases of fibrous dysplasia and 23 cases of ossifying fibroma were reviewed. The overall incidence of GNAS mutations in fibrous dysplasia was 86% (264/307), and the major types of mutations were also R201H (53%) and R201C (45%). No GNAS mutation was detected in all patients with ossifying fibroma. We also reported one case with uncertain diagnosis due to overlapping clinicopathological features of fibrous dysplasia and ossifying fibroma. An R201H mutation was detected in this case, thus confirming a diagnosis of fibrous dysplasia. Taken together, our findings indicate that mutational analysis of GNAS gene is a reliable adjunct to differentiate ossifying fibroma and fibrous dysplasia of the jaws. PMID:23503642

  2. A large infiltrating fibrous hamartoma of infancy in the abdominal wall with rare associated tuberous sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Han, Hye-Jeong; Lim, Gye-Yeon [The Catholic University of Korea, Department of Radiology, St. Mary' s Hospital, Seoul (Korea); You, Chang-Young [The Catholic University of Korea, Department of Pathology, St. Mary' s Hospital, Seoul (Korea)

    2009-07-15

    Tuberous sclerosis is a complex autosomal-dominant neurocutaneous syndrome characterized by hamartomatous malformations of fibrous and connective tissues in various organs. Although various histologic types of soft-tissue masses can occur with tuberous sclerosis, we present a unique case of fibrous hamartoma of infancy presenting as large infiltrating cutaneous and subcutaneous masses in the abdominal wall in a 4-year-old boy with tuberous sclerosis. Although the co-occurrence of tuberous sclerosis and fibrous hamartoma of infancy is very rare, it should be considered in the differential diagnosis of subcutaneous soft-tissue masses found in children with tuberous sclerosis. (orig.)

  3. A large infiltrating fibrous hamartoma of infancy in the abdominal wall with rare associated tuberous sclerosis

    International Nuclear Information System (INIS)

    Tuberous sclerosis is a complex autosomal-dominant neurocutaneous syndrome characterized by hamartomatous malformations of fibrous and connective tissues in various organs. Although various histologic types of soft-tissue masses can occur with tuberous sclerosis, we present a unique case of fibrous hamartoma of infancy presenting as large infiltrating cutaneous and subcutaneous masses in the abdominal wall in a 4-year-old boy with tuberous sclerosis. Although the co-occurrence of tuberous sclerosis and fibrous hamartoma of infancy is very rare, it should be considered in the differential diagnosis of subcutaneous soft-tissue masses found in children with tuberous sclerosis. (orig.)

  4. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Rigali

    2001-10-01

    Published mechanical and thermal properties data on a variety of materials was gathered, with focus on materials that have potential with respect to developing wear resistant and damage tolerant composite for mining industry applications. Preliminary core materials of interest include but are not limited to: Diamond, Tungsten Carbide and Cemented Tungsten Carbides, Carbides of Boron, Silicon, Titanium and Aluminum, Diboride of Titanium and Aluminum, Nitrides of Aluminum, Silicon, Titanium, and Boron, Aluminum Oxide, Tungsten, Titanium, Iron, Cobalt and Metal Alloys. Preliminary boundary materials of interest include but are not limited to: W metal, WC-Co, W-Co, WFeNi, and Mo metal and alloys. Several FM test coupons were fabricated with various compositions using the above listed materials. These coupons were consolidated to varying degrees by uniaxial hot pressing, then cut and ground to expose the FM cell structure. One promising system, WC-Co core and WFeNi boundary, was consolidated to 97% of theoretical density, and demonstrates excellent hardness. Data on standard mechanical tests was gathered, and tests will begin on the consolidated test coupons during the upcoming reporting period. The program statements of work for ACR Inc. and its subcontractors, as well as the final contract negotiations, were finalized during the current reporting period. The program start date was February 22nd, 2001. In addition to the current subcontractors, Kennametal Inc., a major manufacturer of cutting tools and wear resistant tooling for the mining industry, expressed considerable interest in ACR's Fibrous Monolith composites for both machine and mining applications. At the request of Kennametal, ARC Inc fabricated and delivered several Fibrous Monolith coupons and components for testing and evaluation in the mining and machine tool applications. Additional samples of Diamond/Tungsten Carbide-6%Cobalt Fibrous Monolith were fabricated and delivered for testing Kennametal's Rapid Omni-directional Consolidation (ROC) Process. A meeting was held with Kennametal Inc. September 27th, 2001. At this meeting, Kennametal expressed interest in working with ACR on three mining tool applications including roof bits, point attack tooling and drill bit inserts. In addition, there is considerable interest in developing FM composite machine cutting tools, which involves crosscutting technology. In addition to the discussions on business development, Kennametal reported on testing performed on ACR's FM composites the first quarter of this year. ACR Inc. also visited Tribocor Inc. of Houston TX to discuss the possibility of teaming to consolidate diamond/WC-Co composite coatings. Diamond-based composites require special high pressure consolidation equipment and Tribocor has expressed an interest in providing diamond powder preparation and consolidation services, to enable the mass-production of a low cost diamond-based FM composite products including drill bit inserts and point attack tools. Tribocor has agreed to perform consolidation of diamond/WC-Co FM coated inserts to verify their consolidation process and produce test pieces that we can press into mining drill bits for field testing.

  5. NAB2-STAT6 gene fusion and STAT6 immunoexpression in extrathoracic solitary fibrous tumors: the association between fusion variants and locations.

    Science.gov (United States)

    Chuang, I-Chieh; Liao, Kuan-Cho; Huang, Hsuan-Ying; Kao, Yu-Chien; Li, Chien-Feng; Huang, Shih-Chiang; Tsai, Jen-Wei; Chen, Ko-Chin; Lan, Jui; Lin, Po-Chun

    2016-05-01

    Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm harboring NAB2-STAT6 fusion, which drives STAT6 nuclear relocation. For extrathoracic SFTs, the clinical relevance of this molecular hallmark remains obscure. We assessed STAT6 immunoexpression for 61 extrathoracic SFTs exclusive of the meninges and head and neck, and 25 had analyzable RNAs to distinguish fusion variants by RT-PCR. The immunohistochemical and molecular findings were correlated with clincopathological features and disease-free survival (DFS). Twenty-eight males and 33 females had SFTs in the body cavities (n聽=聽31), extremities (n聽=聽17), and trunk (n聽=聽13), categorized into 53 non-malignant and 8 malignant tumors. The vast majority (n聽=聽57, 93%) exhibited distinctive STAT6 nuclear expression, including malignant ones. The common fusion variants were NAB2ex6-STAT6ex16/17 in 13 SFTs and NAB2ex4-STAT6ex2 in 8, while miscellaneous variants were detected only in 4 SFTs in the limbs and trunk but not in any body cavity-based cases (P聽=聽0.026). The worse DFS was univariately associated with malignant histology (P聽=聽0.04) but unrelated to tumor size, location, or fusion variant. Conclusively, extrathoracic SFTs mostly harbor NAB2ex6-STAT6ex16/17, followed by NAB2ex4-STAT6ex2. Miscellaneous variants are significantly rare in SFTs within the body cavities. The clinical aggressiveness of extrathoraic SFTs is associated with malignant histology but unrelated to the NAB2-STAT6 fusion variants. PMID:27039712

  6. 3D MORPHOLOGICAL MODELLING OF A RANDOM FIBROUS NETWORK

    Directory of Open Access Journals (Sweden)

    Charles Peyrega

    2011-05-01

    Full Text Available In the framework of the Silent Wall ANR project, the CMM and the US2B are associated in order to characterize and to model fibrous media studying 3D images acquired with an X-Ray tomograph used by the US2B. The device can make 3D images of maximal 23043 voxels with resolutions in the range of 2 渭m to 15 渭m. Using mathematical morphology, measurements on the 3D X-Ray CT images are used to characterize materials. For example measuring the covariance on these images of an acoustic insulating material made of wooden fibres highlights the isotropy of the fibres orientations in the longitudinal planes which are perpendicular to the compression Oz axis. Moreover, it is possible to extract other morphological properties from these image processing methods such as the size distribution either of the fibres or of the pores by estimating the morphological opening granulometry of the considered medium. Using the theory of random sets introduced by Georges Matheron in the early 1970's, the aim of this work is to model such a fibrous material by parametric random media in 3D according to the prior knowledge of its morphological properties (covariance, porosity, size distributions, etc.. A Boolean model of random cylinders in 3D stacked in planes parallel to each other and perpendicular to the Oz compression axis is first considered. The granulometry results provide gamma distributions for the radii of the fibres. In addition, a uniform distribution of the orientations is chosen, according to the experimental isotropy measurements in the longitudinal planes. Finally the third statistical factor is the length distribution of the fibres which can be fitted by an exponential distribution. Thus it is possible to estimate the validity of this model first by trying to fit the experimental transverse and longitudinal covariances of the pores with the theoretical ones taking into account the statistical distributions of the dimensions of the random cylinders. The second method to validate the model consists in comparing morphological measurements (density profiles, covariance, opening granulometry, tortuosity, specific surface area processed on real and on simulated media.

  7. Meningioma maligno Malignant meningioma

    Directory of Open Access Journals (Sweden)

    Yvei Gonz谩lez Orlandi

    2011-03-01

    Full Text Available Los meningiomas intracraneales son tumores por lo general benignos, de crecimiento lento, y se originan en la capa de c茅lulas aracnoideas, especialmente en las granulaciones aracnoideas. Los meningiomas anapl谩sicos o malignos representen solo el 1-3 %. En ocasiones simulan lesiones tumorales neuroepiteliales malignas, por su crecimiento r谩pido y la frecuente invasi贸n al tejido cerebral vecino; suelen recidivar con mayor frecuencia y muchas veces requieren terapia coadyuvante. Las im谩genes topogr谩ficas de este tipo de tumores suelen ser hiperdensas, con muy buena captaci贸n del contraste, regulares y bien delimitadas con poco o ning煤n edema asociado, todo lo contrario a lo visto en el caso que se presenta, en el cual las im谩genes parec铆an corresponder a las de un glioma maligno (glioblastoma multiforme.The intracranial meningiomas are tumors in general of benign type of a slow growth originating in the arachnoid cells layer, especially in arachnoid granulations. The anaplastic or malignant meningiomas accounted for only the 1-3%. Sometimes they simulate malignant neuroepithelial lesions due to its fast growth and the frequent invasion of surrounding cerebral tissue with very frequent relapses and many times they required adjuvant therapy. The topographic images of this type of tumor are hyper-denses with a good contrast capture, regular and well defined with not much or not associated edema, quite the contrary that observed in present case where images seems to correspond with those of a malignant glioma (multiforme glioblastoma.

  8. Helminths and malignancy

    DEFF Research Database (Denmark)

    Vennervald, Birgitte J; Polman, K.

    2009-01-01

    number of people who are exposed or infected worldwide. Carcinogenesis associated with helminth infections is a complex process, which may involve several different mechanisms, but chronic inflammation is a key feature. Host immune responses and immunopathological processes mediate inflammatory responses......-malignant change has taken place. Three helminth infections have been classified as definitely carcinogenic to humans (group 1 carcinogens), namely Schistosoma haematobium, which is associated with cancer of the urinary bladder and the food-borne liver flukes Clonorchis sinensis and Opisthorchis viverrini...

  9. Radiotherapy of malignant melanoma

    International Nuclear Information System (INIS)

    In the last years is increasing clinical evidence to contradict the well-established idea that melanomas are uniformly radiation resistant. Although surgery remains the first choice for most localized melanoma, radiotherapy is an alternative in a small subgroup of patients in whom the surgery was associated with a deformity, for example in lentigo malign melanoma localized on the face, and in melanoma of the UVEA. Adjuvant radiation therapy following lymphadenectomy in node positive melanoma prevents local and regional recurrence. Stereotactic radiosurgery for brain metastases has shown effective local control The radiotherapy is likely to play a greater role in melanoma management. (author)

  10. Second malignancy in relation to treatment modality of primary malignancy

    International Nuclear Information System (INIS)

    Second malignant tumors among long-term survivors are a sensitive indicator of successful oncologic treatment, particularly in this area of multimodal therapy. 11 patients of abdominopelvic primary malignancy were detected to have a second malignancy of different pathology, and at a different site. These patients were assessed regarding treatment modality of initial cancer and time gap between the first and second malignancy. Lack of proper cancer registries, illiteracy, and lack of resources lead to poor patient follow-up; therefore population based studies is not possible

  11. Solitary fibrous tumor of the kidney: a case report

    OpenAIRE

    Gustavo Soares Corr阛 Silva; Maur韈io Buzelin Nunes; Pedro Bastos Guimar鉫s de Almeida; Rafael Morroni de Oliveira; Risia Edwiges de Oliveira Guimar鉫s; Victor Satler Pylro

    2014-01-01

    We describe a case report of a rare cancer affecting the kidney of 63 years of age patient who underwent imaging studies from ultrasound, computed tomography, and magnetic resonance imaging, due to complaints: left back pain and urinary obstruction. Sonographic and radiological features of the mass found suggested the diagnosis of a malignant tumor of parenchymal origin. The pathological and immunohistochemical studies of the resected anatomical specimen, however, diagnosed a rare benign vari...

  12. Novel two-step method to form silk fibroin fibrous hydrogel.

    Science.gov (United States)

    Ming, Jinfa; Li, Mengmeng; Han, Yuhui; Chen, Ying; Li, Han; Zuo, Baoqi; Pan, Fukui

    2016-02-01

    Hydrogels prepared by silk fibroin solution have been studied. However, mimicking the nanofibrous structures of extracellular matrix for fabricating biomaterials remains a challenge. Here, a novel two-step method was applied to prepare fibrous hydrogels using regenerated silk fibroin solution containing nanofibrils in a range of tens to hundreds of nanometers. When the gelation process of silk solution occurred, it showed a top-down type gel within 30min. After gelation, silk fibroin fibrous hydrogels exhibited nanofiber network morphology with ?-sheet structure. Moreover, the compressive stress and modulus of fibrous hydrogels were 31.92.6 and 2.80.8kPa, respectively, which was formed using 2.0wt.% concentration solutions. In addition, fibrous hydrogels supported BMSCs attachment and proliferation over 12days. This study provides important insight in the in vitro processing of silk fibroin into useful new materials. PMID:26652363

  13. Case report 207: Giant cell reparative granuloma of left femur arising in polyostatic fibrous dysplasia

    International Nuclear Information System (INIS)

    Diagnosis and differential diagnosis of lytic lesions in the femur are discussed. Roentgenograms, a tomogram and pathological studies of a giant cell reparative granuloma of left femur arising in polyostotic fibrous dysplasia are presented. (WU)

  14. Assessment of fibrous insulation materials for the selenide isotope generator system

    International Nuclear Information System (INIS)

    Fibrous insulations for use in the converter and the heat source of the radioisotope-powered, selenide element, thermoelectric generator (selenide isotope generator) are assessed. The most recent system design and material selection basis is presented. Several fibrous insulation materials which have the potential for use as load-bearing or nonload-bearing thermal insulations are reviewed, and thermophysical properties supplied by manufacturers or published in the literature are presented. Potential problems with the application of fibrous insulations in the selenide isotope generator are as follows: compatibility with graphite, the thermoelectric elements, and the isolation hot frame; devitrification, grain growth, and sintering with an accompanying degradation of insulation quality; impurity diffusion from the insulation to adjoining structures; outgassing and storage of fibrous materials. Areas in which thermophysical data or quantitative information on the insulation and structural stability is lacking are identified

  15. Assessment of fibrous insulation materials for the selenide isotope generator system

    Energy Technology Data Exchange (ETDEWEB)

    Wei, G.C; Tennery, V.J.

    1977-11-01

    Fibrous insulations for use in the converter and the heat source of the radioisotope-powered, selenide element, thermoelectric generator (selenide isotope generator) are assessed. The most recent system design and material selection basis is presented. Several fibrous insulation materials which have the potential for use as load-bearing or nonload-bearing thermal insulations are reviewed, and thermophysical properties supplied by manufacturers or published in the literature are presented. Potential problems with the application of fibrous insulations in the selenide isotope generator are as follows: compatibility with graphite, the thermoelectric elements, and the isolation hot frame; devitrification, grain growth, and sintering with an accompanying degradation of insulation quality; impurity diffusion from the insulation to adjoining structures; outgassing and storage of fibrous materials. Areas in which thermophysical data or quantitative information on the insulation and structural stability is lacking are identified.

  16. Classical radiological aspects of fibrous dysplasia; Aspectos radiologicos classicos da displasia fibrosa nas radiografias do cranio

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Norma Selma Santos; Moraes e Silva, Denise; Lederman, Henrique M. [Escola Paulista de Medicina, Sao Paulo, SP (Brazil)

    1996-07-01

    The authors, after a review of the literature, show the features of fibrous dysplasia in the skull through conventional radiology, depicting the most common and classics aspects of this disease and its differential diagnosis. (author) 6 refs., 4 figs.

  17. Alternating magnetic field heat behaviors of PVDF fibrous mats filled with iron oxide nanoparticles

    Science.gov (United States)

    Kim, Jinu; Choi, Jung-Su; Yang, Heejae; Ko, Frank K.; Kim, Ki Hyeon

    2016-05-01

    To study the magnetic heat behaviors, iron oxide nanoparticles (IONPs) and the polyvinylidene fluoride (PVDF) fibrous mats filled with IONPs were prepared by using coprecipitaion method and the electrospinning technique. The synthesized IONPs exhibited a magnetization of about 72 emu/g with average diameter of about 10 nm. The magnetizations of PVDF fibrous mats filled with IONPs showed 2.6 emu/g, 5.5 emu/g and 9.9 emu/g for 5 wt.%, 10 wt.% and 20 wt.% IONPs concentration, respectively. The heat of the magnetic fibrous mats were measured under various alternating magnetic fields (90, 128, and 167 Oe), frequencies (190, 250 and 355 kHz). The maximum saturated temperature showed up to 62 掳C for 20 wt.% IONPs filled in PVDF fibrous mat under 167 Oe and 355 kHz.

  18. Radioimmunotherapy of malignancies

    International Nuclear Information System (INIS)

    The critical issues in radioimmunotherapy are highlighted, and novel ways of improving the therapeutic indexes of radioimmunotherapeutic agents are outlined. The use of radioactively labeled monoclonal antibodies to treat malignant tumors has been investigated in animals and humans. Radionuclides suitable for labeling antibodies for such use include iodine 125, iodine 131, yttrium 90, rhenium 188, and copper 67. Radiobiological factors to be considered in radioimmunotherapy include the size and density of the tumor and the ability of a radiolabeled antibody to penetrate the tumor nodule. The dose of radiation required to destroy a tumor varies; however, the whole-body dose must not exceed 200 rads to avoid irreversible toxicity to the bone marrow. Despite the theoretical inadequacy of radiation doses to tumors indicated by conventional dosimetry, responses have been observed in animals and humans. More reliable and accurate dosimetric methods are under development. The induction of human antimouse antibodies can alter the pharmacokinetics of radiolabeled antibodies. Improving the therapeutic index of radioimmunotherapeutic agents may be achieved through regional therapy, administering a secondary antibody to improve clearance, combining radioimmunotherapy with external-beam irradiation, using an avidin-biotin conjugate system to deliver the radiolabeled antibodies, and addressing the problem of tumor antigen heterogeneity. Researchers are working to reduce or eliminate the clinical problems associated with radioimmunotherapy. Hematologic malignancies, such as lymphomas, are more likely than solid tumors to respond satisfactorily. 110 refs

  19. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY; SEMIANNUAL

    International Nuclear Information System (INIS)

    During this reporting period, work continued on development of formulations using the materials identified as contenders for the fibrous monolith wear resistant components. The FM structures fabricated were: diamond/WC-Co, B(sub 4)C/WC-Co, TiB(sub 2)/WC-Co, WC-Co/Co, WC-Co/WC-Co. Results of our consolidation densification studies on these systems lead to the down-selection of WC-Co/WC-Co, WC-Co/Co and diamond/WC-Co for further development for mining applications including drill bit inserts, roof bit inserts, radial tools conical tools and wear plates (WC-Co based system only) for earth moving equipment. Prototype component fabrication focused on the fabrication of WC-Co/WC-Co FM conical tools, diamond/WC-Co coated drill bit insert prototypes. Fabrication of WC-Co/WC-Co FM insert prototypes for a grader blade is also underway. ACR plans to initiate field-testing of the drill bit insert prototypes and the grader blade insert this summer (2002). The first WC-Co/WC-Co FM conical tool prototypes were sent to Kennametal for evaluation towards the end of the current reporting period

  20. Fibrous dysplasia of the clivus: A Case Report

    Directory of Open Access Journals (Sweden)

    Lewis D

    2007-01-01

    Full Text Available Introduction:Fibrous dysplasia (FD of the clivus, first described by Lichtenstein in 1938, is a very rare developmental, non-hereditary disorder caused by abnormal proliferation and maturation of fibroblasts resulting in replacement of mature bone by weak and immature bone.Case reportA 26-year-old otherwise fit and healthy Caucasian female presented to the Emergency Department with headache for 3 days, recurrent and getting worse. Neurological examination was normal. Blood investigations were essentially normal. Head CT scan showed slightly expanded clivus with ground glass density. MRI revealed slight expansion with focal signal alteration within the clivus, being hypointense on T1W images and FLAIR images and showing slightly increased signal intensity on T2W image.While in hospital the patient鈥檚 symptoms resolved with conventional painkiller treatment. Based on the current evidence available we opted for a conservative treatment and regular follow-ups and up to the day of writing this report, about eight months later, the patient is still on the same management plan.

  1. Fast numerical upscaling of heat equation for fibrous materials

    KAUST Repository

    Iliev, Oleg

    2010-08-01

    We are interested in numerical methods for computing the effective heat conductivities of fibrous insulation materials, such as glass or mineral wool, characterized by low solid volume fractions and high contrasts, i.e., high ratios between the thermal conductivities of the fibers and the surrounding air. We consider a fast numerical method for solving some auxiliary cell problems appearing in this upscaling procedure. The auxiliary problems are boundary value problems of the steady-state heat equation in a representative elementary volume occupied by fibers and air. We make a simplification by replacing these problems with appropriate boundary value problems in the domain occupied by the fibers only. Finally, the obtained problems are further simplified by taking advantage of the slender shape of the fibers and assuming that they form a network. A discretization on the graph defined by the fibers is presented and error estimates are provided. The resulting algorithm is discussed and the accuracy and the performance of the method are illusrated on a number of numerical experiments. 漏 Springer-Verlag 2010.

  2. Fibrous adsorbent for removal of aqueous aromatic hydrocarbons.

    Science.gov (United States)

    Jung, Yong-Jun; Kiso, Yoshiaki; Oguchi, Tatsuo; Yamada, Toshiro; Takagi, Hiroo; Nishimura, Kazuyuki

    2007-01-01

    Bundles of a strongly hydrophobic fibrous material (p-phenylene-2,6-benzobisoxazole; PBO; Zylon) were employed as an adsorbent for the removal of aqueous aromatic compounds, because the PBO fibers are too rigid to be woven and did not entrap suspended solids. The removal performance for nine kinds of polyaromatic hydrocarbons (PAHs) and di-(2-ethylhexyl) phthalate (DEHP) was evaluated. PAHs and DEHP at initial concentrations of 50 microg L(-1) were removed at 72.5-99.9% and ca. 95%, respectively, although the removal efficiencies were affected by the phase ratio (fiber weight/solution volume). The logarithm of the partition coefficient (log K) for planar PAHs was linearly correlated with the logarithm of the n-octanol/water partition coefficient (log P), but nonplanar PAHs, such as cis-stilbene, p-terphenyl, and o-terphenyl, showed significantly lower adsorption performance. The adsorbed PAHs were not desorbed effectively with CH3CN, CH2Cl2, and toluene. On the other hand, DEHP was effectively desorbed with methanol. PMID:17585293

  3. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Rigali; Kenneth L. Knittel; Mike L. Fulcher

    2002-03-01

    During this reporting period, work continued on development of formulations using the materials identified as contenders for the fibrous monolith wear resistant components. The FM structures fabricated were: diamond/WC-Co, B{sub 4}C/WC-Co, TiB{sub 2}/WC-Co, WC-Co/Co, WC-Co/WC-Co. Results of our consolidation densification studies on these systems lead to the down-selection of WC-Co/WC-Co, WC-Co/Co and diamond/WC-Co for further development for mining applications including drill bit inserts, roof bit inserts, radial tools conical tools and wear plates (WC-Co based system only) for earth moving equipment. Prototype component fabrication focused on the fabrication of WC-Co/WC-Co FM conical tools, diamond/WC-Co coated drill bit insert prototypes. Fabrication of WC-Co/WC-Co FM insert prototypes for a grader blade is also underway. ACR plans to initiate field-testing of the drill bit insert prototypes and the grader blade insert this summer (2002). The first WC-Co/WC-Co FM conical tool prototypes were sent to Kennametal for evaluation towards the end of the current reporting period.

  4. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Rigali; Mike L. Fulcher; Kenneth L. Knittel

    2002-10-01

    During the reporting period, work continued on development of formulations using the materials down-selected from the initially identified contenders for the fibrous monolith wear resistant components. The FM systems studied were: WC-Co/WC-Co, WC-Co/Co, diamond/WC-Co, and Al{sub 2}O{sub 3}/Al{sub 2}O{sub 3}-TiCN. Extrudable formulations for the materials listed were developed during the first twelve months of this effort, and work during the reporting period was focused on the development of optimized binder removal processes. A two stage binder removal process was developed that resulted in prototype parts free of voids and other internal defects. In addition, changes in the binder removal atmosphere resulted in the apparent elimination of residual carbon, an important consideration when consolidating WC-Co containing systems. Using the improved binder removal processes, parts were consolidated by both sintering and hot pressing to >99% theoretical density. Samples of these materials were sent to Kyocera for mechanical evaluations. Fabrication of drill bit inserts was begun, and binder removal begun during the reporting period. A total of 24 green inserts were fabricated, and will be consolidated and delivered for field testing during the upcoming reporting period.

  5. Sperm protein 17 is expressed in the sperm fibrous sheath

    Directory of Open Access Journals (Sweden)

    Albani Elena

    2009-07-01

    Full Text Available Abstract Background Sperm protein 17 (Sp17 is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues. It was also recognized in two myeloma cell lines and in neoplastic cells from patients with multiple myeloma and ovarian carcinoma. These data all indicate that Sp17 is widely distributed in humans, expressed not only in germinal cells and in a variety of somatic tissues, but also in neoplastic cells of unrelated origin. Methods Sp17 expression was analyzed by immunocytochemistry and transmission electron microscopy on spermatozoa. Results Here, we demonstrate the ultrastructural localization of human Sp17 throughout the spermatozoa flagellar fibrous sheath, and its presence in spermatozoa during in vitro states from their ejaculation to the oocyte fertilization. Conclusion These findings suggest a possible role of Sp17 in regulating sperm maturation, capacitation, acrosomal reaction and interactions with the oocyte zona pellucida during the fertilization process. Further, the high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP-binding motif within this region, suggest that Sp17 might play a regulatory role in a protein kinase A-independent AKAP complex in both germinal and somatic cells.

  6. Applications of phase change polymers in fibrous substrates

    International Nuclear Information System (INIS)

    This paper reports on insolubilization of polyethylene glycols (Mn of 600-20,000) onto a variety of fibrous substrates by reaction with a methylolamide resin (DMDHEU or dimethyloldihydroxyethyleneurea) in the presence of acid catalysts produced modified materials that have several improved functional properties and that are useful for numerous applications. Crosslinking or insolubilization of the polyols occurs under mild cuing conditions (80-100 degrees C). The resultant properties of the modified substrate (essentially a flexible composite of fiber and crosslinked polyol in the matrix) are markedly dependent on the proper choice of curing conditions (time and temperature). Representative fiber types and blends that have been modified by this process include: cotton, polyester, polyamide, cotton blends, wool blends, aramids, glass, acrylic, polypropylene, elastomeric fibers and short fibers used to make paper. All types of fabric constructions have been used (woven, nonwoven, and knit). The most novel property is the thermal adaptability of the modified fabrics or substrates to a variety of climatic conditions. This adaptability is due to the high enthalpy of fusion (cooling effect in hot weather) and crystallization (liberation of heat in cold weather) of the crosslinked polyethylene glycols (insolubilized phase change materials or PCM's). The novel thermal effects are due to the hydrophilic nature of the crosslinked polyol as well as its reduced thermal conductivity. Thermal profiles of the modified materials have been characterized by differential scanning calorimetry, infrared thermography, and by limited wear trials with garments containing the polymeric PCM's. There are other enhanced functional properties of the modified fabrics

  7. Human exposure to carbon-based fibrous nanomaterials: A review.

    Science.gov (United States)

    Guseva Canu, Irina; Bateson, Thomas F; Bouvard, Veronique; Debia, Maximilien; Dion, Chantal; Savolainen, Kai; Yu, Il-Je

    2016-03-01

    In an emerging field of nanotechnologies, assessment of exposure to carbon nanotubes (CNT) and carbon nanofibers (CNF) is an integral component of occupational and environmental epidemiology, risk assessment and management, as well as regulatory actions. The current state of knowledge on exposure to carbon-based fibrous nanomaterials among workers, consumers and general population was studied in frame of the International Agency for Research on Cancer (IARC) Monographs-Volume 111 "Some Nanomaterials and Some Fibres". Completeness and reliability of available exposure data for use in epidemiology and risk assessment were assessed. Occupational exposure to CNT/CNF may be of concern at all stages of the material life-cycle from research through manufacture to use and disposal. Consumer and environmental exposures are only estimated by modeled data. The available information of the final steps of the life-cycle of these materials remains incomplete so far regarding amounts of handled materials and levels of exposure. The quality and amount of information available on the uses and applications of CNT/CNF should be improved to enable quantitative assessment of human exposure to these materials. For that, coordinated effort in producing surveys and exposure inventories based on harmonized strategy of material test, exposure measurement and reporting results is strongly encouraged. PMID:26752069

  8. Antibacterial Biphenanthrenes from the Fibrous Roots of Bletilla striata.

    Science.gov (United States)

    Qian, Chao-Dong; Jiang, Fu-Sheng; Yu, Hang-Su; Shen, Yong; Fu, Yu-Hang; Cheng, Dong-Qing; Gan, Li-She; Ding, Zhi-Shan

    2015-04-24

    Four new 9',10'-dihydro-biphenanthrenes, including an unprecedented 1,2'-linked biphenanthrene, 4,7,3',5'-tetramethoxy-9',10'-dihydro(1,2'-biphenanthrene)-2,7'-diol (1), a new 1,3'-linked biphenanthrene, 4,7,7'-trimethoxy-9',10'-dihydro(1,3'-biphenanthrene)-2,2',5'-triol (2), and two new 1,1'-linked biphenanthrenes, 4,7,4'-trimethoxy-9',10'-dihydro(1,1'-biphenanthrene)-2,2',7'-triol (3) and 4,7,3',5'-tetramethoxy-9',10'-dihydro(1,1'-biphenanthrene)-2,2',7'-triol (4), as well as two known biphenanthrenes (5, 6), were isolated from a 95% ethanol extract of the fibrous roots of Bletilla striata. Their structures were determined by spectroscopic and spectrometric methods. Atropisomerism of these compounds was considered based on their chiral optical properties and potential energy surface scans at the ab initio HF/3-21G level, which revealed their racemic mixture form. Compounds 2-6 showed potent antibacterial activities against six Gram-positive bacterial strains. PMID:25760525

  9. Use of artificial intelligence techniques for diagnosis of malignant pleural mesothelioma

    Directory of Open Access Journals (Sweden)

    Orhan Er

    2015-03-01

    Full Text Available Objective: Malignant pleural mesothelioma is a highly aggressive tumor of the serous membranes, which in humans results from exposure to asbestos and asbestiform fibers. The incidence of malignant mesothelioma is extremely high in some Turkish villages where there is a low-level environmental exposure to erionite, a fibrous zeolite. Therefore epidemiological studies are difficult to perform in Turkey. Methods: In this paper, a study on malignant pleural mesothelioma disease diagnosis was realized by using artificial immune system. Also, the artificial immune system result was compared with the result of the multi-layer neural network focusing on malignant pleural mesothelioma disease diagnosis and using same database. The malignant pleural mesothelioma disease dataset were prepared from a faculty of medicine抯 database using patient抯 hospital reports. Results: 97.74% accuracy performance is obtained by artificial immune system. The accuracy results of artificial immune system algorithm are much better than the accuracy results of multi-layer neural network algorithm. Conclusion: This system is capable of conducting the classification process with a good performance to help the expert while deciding the healthy and patient subjects. So, this structure can be helpful as learning based decision support system for contributing to the doctors in their diagnosis decisions.

  10. Mortal postpartum neuroleptic malignant syndrome

    OpenAIRE

    脺st眉nda臒, Mehmet; Orak, Murat; G眉lo臒lu, Cahfer; Do臒an, Halil; Uysal, Emin

    2006-01-01

    Neuroleptic malignant syndrome is a serious side effect caused by antipsychotic medications. Neuroleptic malignant syndrome is believed to be triggered by neuroleptic blockade of dopaminergic receptors located in the hypothalamus and basal ganglia. The incidence of neuroleptic malignant syndrome with conventional antipsychotic agents has been reported to vary from 0.02-2.44%. Manifestations of this syndrome include severe muscle rigidity and high temperature with any of the following symptoms...

  11. Cytogenetic characterization of a fibrous hamartoma of infancy with complex translocations.

    Science.gov (United States)

    Tassano, Elisa; Nozza, Paolo; Tavella, Elisa; Garaventa, Alberto; Panarello, Claudio; Morerio, Cristina

    2010-08-01

    Fibrous hamartoma of infancy is a rare pediatric superficial soft tissue lesion. The diagnosis depends on microscopic examination. Conventional cytogenetic analysis has been reported in only two previous cases, which showed apparently balanced translocations with involvement of different chromosomes. In the present study, we used multicolor fluorescence in situ hybridization to characterize a case of fibrous hamartoma of infancy that had arisen in an unusual location. This molecular analysis revealed complex structural rearrangements involving chromosomes 1, 2, 4, and 17. PMID:20633773

  12. Liquid perfluorochemical-supported hybrid cell culture system for proliferation of chondrocytes on fibrous polylactide scaffolds

    OpenAIRE

    Pilarek, Maciej; Grabowska, Iwona; Senderek, Ilona; Wojasi艅ski, Micha艂; Janicka, Justyna; Janczyk-Ilach, Katarzyna; Ciach, Tomasz

    2014-01-01

    CP5 bovine chondrocytes were cultured on biodegradable electrospun fibrous polylactide (PLA) scaffolds placed on a flexible interface formed between two immiscible liquid phases: (1) hydrophobic perfluorochemical (PFC) and (2) aqueous culture medium, as a new way of cartilage implant development. Robust and intensive growth of CP5 cells was achieved in our hybrid liquid鈥搒olid鈥搇iquid culture system consisting of the fibrous PLA scaffolds in contrast to limited growth of the CP5 cells in tradit...

  13. Hypertrophied anal papillae and fibrous anal polyps, should they be removed during anal fissure surgery?

    OpenAIRE

    Pravin J. Gupta

    2004-01-01

    Objective:聽 The present study is aimed to establish thathypertrophied anal papillae and fibrous anal polyps cancause symptoms and could cause concern to thepatients and that these should be removed whiledealing with patients of chronic fissure in ano.Method: Two groups of patients were studied. One-hundred patients were studied in Group A where theassociated fibrous polyp or papillae were removed byradio frequency surgical device after performing alateral subcutaneous sphincterotomy for relie...

  14. Disease severity and functional factors associated with walking performance in polyostotic fibrous dysplasia

    OpenAIRE

    Scott M Paul; Gabor, Lisa R.; Rudzinski, Scott; Giovanni, David; Boyce, Alison M.; Kelly, Marilyn R.N.; Collins, Michael T.

    2013-01-01

    The purpose of this study was to determine the association between measures of disease severity, impairment, and ambulation ability in persons with polyostotic fibrous dysplasia (PFD). A cross-sectional sample of 81 patients (ages 5鈥57) with polyostotic fibrous dysplasia was evaluated as part of an ongoing study. Subjects were scored on the Skeletal Disease Burden Score (SDBS), completed a 9-minute walk test (9MW), manual muscle testing (MMT), and measurements of range of motion (ROM). Correl...

  15. Micro-poromechanics model of fluid-saturated chemically active fibrous media

    OpenAIRE

    MISRA, Anil; Parthasarathy, Ranganathan; Singh, Viraj; Spencer, Paulette

    2013-01-01

    We have developed a micromechanics based model for chemically active saturated fibrous media that incorporates fiber network microstructure, chemical potential driven fluid flow, and micro-poromechanics. The stress-strain relationship of the dry fibrous media is first obtained by considering the fiber behavior. The constitutive relationships applicable to saturated media are then derived in the poromechanics framework using Hill鈥檚 volume averaging. The advantage of this approach is that the r...

  16. Poliostotic fibrous dysplasia in the left maxilla sinus. Case of presentation.

    Directory of Open Access Journals (Sweden)

    F茅lix Due帽as Ros

    2007-04-01

    Full Text Available We present a clinic case of poliostotic fibrous dysplasia in the left maxilla sinus extended to Pterigopaltinar cavity and sphenoid sinus in a 26 year old woman who suffer from facial deformation. Paranasal x ray images didn鈥檛 permit to make the differential diagnosis between tumor or inflammatory lesions at the beginning, CT scan showed hiperdensy lesions like a tumor that suggest fibrous dysplasia. The final diagnosis was obtained by biopsy of the lesions.

  17. Cystic solitary fibrous tumor arising from the left occipital meninges: a case report

    International Nuclear Information System (INIS)

    Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm of a spindle-cell origin, and it usually involves the pleura. It's occurrence in various organs of the body has recently been described. Meningeal SFT is very rare. Radiologically, it is a strongly enhancing solid mass and is undistinguishable from fibrous meningioma and hemangiopericytoma. Yet we report here on a case of SFT with massive cystic degeneration that arose from the meninges of the left occipital region

  18. Thoracic Outlet Syndrome Caused by Fibrous Dysplasia of the First Rib

    OpenAIRE

    Kemp, Clinton D.; Rushing, Gregory D.; Rodic, Nemanja; McCarthy, Edward; Yang, Stephen C.

    2012-01-01

    Fibrous dysplasia causing thoracic outlet syndrome is rare. A 41-year-old woman presented with neurogenic thoracic outlet syndrome with imaging that demonstrated a large tumor of her proximal left first rib. Transaxillary excision was unsuccessful due to involvement of the subclavian vasculature and brachial plexus. Subsequent posterolateral thoracotomy and resection of her first rib revealed fibrous dysplasia. Thoracotomy should be considered in these cases for optimal vascular control and i...

  19. Application of fibrous complexing sorbents for trace elements preconcentration and separation

    International Nuclear Information System (INIS)

    This paper demonstrates the application of the 'filled' fibrous sorbents for the preconcentration and separation of platinum metals, as well as heavy metals and some radionuclides. It is known that preconcentration is always required for heavy metals and platinum metals determination in complex solution as well as radionuclides reliable monitoring in environment. The fibrous 'filled' complexing sorbents and ion-exchangers have been used in our work. Used matrixes and functional groups of sorbents used in our work are presented. We have also studied the possibility of Pu sorption by filled fibrous sorbents. For Pu sorption from nitric acid solutions it were selected both the well known anion exchanger AV-17-n with quaternary ammonium groups and complexing sorbents POLYORGS 4-n with 3(5)-methylpyrazole groups and POLYORGS 17-n with 1,3(5)- dimethylpyrazole groups in form of 'filled' fibrous materials. Pu sorption is quite selective. The Am(III), Eu(III), U(VI), Pa(V), Np(V), Tc(VII) and Cs(I) were not sorbed under these conditions, and it can be used for plutonium recovery. We have also studied the possibility of Tc extraction. The new types of fibrous sorbents - 'filled' fibrous sorbents are rather perspective for extraction elements from complex solutions, for example, platinum, heavy metals and radionuclides. Filled fibrous sorbents possess of high selectivity and sorption capacity as well as good kinetic properties and they are the most promising for dynamic sorption extraction. The possibility to vary sorbents properties using different filler allows to extract various types of elements from solution by filled fibrous sorbents. Conditions of dynamic extraction of trace elements from different solutions can be calculated on the basis of equilibrium and kinetic characteristics and corresponding mathematical model of(authors)

  20. In vitro cartilage culture: flow, transport and reaction in fibrous porous media

    OpenAIRE

    AHMADI-SENICHAULT, Azita; Lasseux, Didier; LETELLIER, Samuel

    2007-01-01

    Flow and transport in fibrous media are encountered in a wide variety of domains ranging from biotechnology to filtration in chemical engineering. The context of this work is the in vitro cartilage cell culture on a fibrous biodegradable polymer scaffold placed in a bioreactor. A seeding process using a liquid containing cells (chondrocytes) initiates the culture and an imposed continuous flow through the scaffold allows both the transport of nutrients necessary for cell-growth and of metabol...

  1. Aortic Periannular Abscess Invading into the Central Fibrous Body, Mitral Valve, and Tricuspid Valve

    OpenAIRE

    Oh, Hyun Kong; Kim, Nan Yeol; Kang, Min-Woong; Kang, Shin Kwang; Yu, Jae Hyeon; Lim, Seung Pyung; Choi, Jae Sung; Na, Myung Hoon

    2014-01-01

    A 61-year-old man was diagnosed with aortic stenoinsufficiency with periannular abscess, which involved the aortic root of noncoronary sinus (NCS) that invaded down to the central fibrous body, whole membranous septum, mitral valve (MV), and tricuspid valve (TV). The open complete debridement was executed from the aortic annulus at NCS down to the central fibrous body and annulus of the MV and the TV, followed by the left ventricular outflow tract reconstruction with implantation of a mechani...

  2. Cystic solitary fibrous tumor arising from the left occipital meninges: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Bae Geun; Hwang, Yoon Joon; Cha, Soon Joo; Hur, Gham; Kim, Yong Hoon; Kim, Su Young; Seo, Jung Wook; Lee, Ji Young; Kim, Han Seung [Ilsan Paik Hospital, Inje University, School of Medicine, Goyang (Korea, Republic of)

    2007-02-15

    Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm of a spindle-cell origin, and it usually involves the pleura. It's occurrence in various organs of the body has recently been described. Meningeal SFT is very rare. Radiologically, it is a strongly enhancing solid mass and is undistinguishable from fibrous meningioma and hemangiopericytoma. Yet we report here on a case of SFT with massive cystic degeneration that arose from the meninges of the left occipital region.

  3. Fibrous proteins: At the crossroads of genetic engineering and biotechnological applications.

    Science.gov (United States)

    Yigit, Sezin; Dinjaski, Nina; Kaplan, David L

    2016-05-01

    Fibrous proteins, such as silk, elastin and collagen are finding broad impact in biomaterial systems for a range of biomedical and industrial applications. Some of the key advantages of biosynthetic fibrous proteins compared to synthetic polymers include the tailorability of sequence, protein size, degradation pattern, and mechanical properties. Recombinant DNA production and precise control over genetic sequence of these proteins allows expansion and fine tuning of material properties to meet the needs for specific applications. We review current approaches in the design, cloning, and expression of fibrous proteins, with a focus on strategies utilized to meet the challenges of repetitive fibrous protein production. We discuss recent advances in understanding the fundamental basis of structure-function relationships and the designs that foster fibrous protein self-assembly towards predictable architectures and properties for a range of applications. We highlight the potential of functionalization through genetic engineering to design fibrous protein systems for biotechnological and biomedical applications. Biotechnol. Bioeng. 2016;113: 913-929. 漏 2015 Wiley Periodicals, Inc. PMID:26332660

  4. Sunburn and malignant melanoma.

    Science.gov (United States)

    Green, A.; Siskind, V.; Bain, C.; Alexander, J.

    1985-01-01

    We investigated the relationship between cutaneous malignant melanoma and multiple sunburns in the Queensland population. Interview data were gathered from 236 case-control pairs concerning their lifetime experience of severe sunburns, their occupational and recreational sun exposure, and their skin type. Excluding the lentigo maligna melanoma subtype, an association between multiple sunburns and melanoma was evident. After controlling for other major risk factors there was a significant dose-response relationship (P less than 0.05): the estimated relative risk associated with 2-5 sunburns in life was 1.5, and with 6 or more was 2.4. This observation extends the hitherto circumstantial evidence of a causal relationship between exposure to solar ultraviolet radiation and melanoma, and suggests that precautionary measures could prevent the development of this disease in a proportion of cases in fair-skinned populations. PMID:3970815

  5. Lung scans and malignancy

    International Nuclear Information System (INIS)

    An experience of pulmonary isotope scanning carried out with mercury 197 labelled mercury chloride and acetate, cobalt 57-labelled bleomycin, and Cu67 and Cu64 labelled copper citrate was presented. The scans were carried out with various isotopes supplied by the French Atomic Energy Authority, and gave comparable results, which may be summarised as follows: increased uptake in more than 90% of cases of carcinoma, absent uptake in all cases of benign tumour, frequent increased uptake in acute or advanced inflammatory lesions, absence of uptake, very commonly, in tuberculoma and chronic lesions with scar formation. Radio-isotope scan using Cu67 labelled copper citrate permitted discrimination of malignant tumours (increased fixation which showed up best at the 24th hour) from inflammatory lesions (increased fixation which was reduced on the 24th hour). The positive or negative character of the fixation in a given lesions remains the same, whatever the isotope used in our experience

  6. Fulminant metastatic malignant melanoma

    Directory of Open Access Journals (Sweden)

    N.M.K. Faheem,

    2012-07-01

    Full Text Available A 50-year-old lady presented with complaints of chest pain and cough for the past one month. Right supraclavicular lymphadenopathy, bilateral pleural effusion were present. Fine needle aspiration cytology (FNAC from the lymph node showed brownish-black pigment laden tumour cells. Review of history subsequently revealed that she had undergone a surgical procedure over the sole of her left foot three years ago of which no records were available. Reexamination of sole of left foot showed a pigmented infiltraling lesion. Pleural biopsy revealed pigmented tumour deposits. The patient was diagnosed to have fulminant metastatic malignant melanoma of left foot with metastasis to cervical lymph nodes and pleura. This case report re-emphasizes the importance of combined approach to ascertain diagnosis early.

  7. Lower gastrointestinal malignancies

    International Nuclear Information System (INIS)

    Objective: This refresher course will review the current knowledge as well as ongoing and future research strategies in lower gastrointestinal malignancies. Radiation therapy has a significant role in the adjuvant treatment of lower gastrointestinal malignancies. Furthermore, there are data to suggest that radiation therapy is an integral component of the conservative management (organ preservation) of rectal and anal cancers. 1. Colon cancer. The standard adjuvant treatment for node positive or high risk transmural colon cancer is postoperative 5-FU and Levamisole. There are retrospective data to suggest that certain subsets of high risk patients may benefit from postoperative radiation therapy. 2. Rectal cancer. Randomized trials have revealed an advantage of postoperative radiation therapy plus chemotherapy in transmural and/or node positive rectal cancer. In the adjuvant setting the use of continuous infusion 5-FU may be more beneficial compared with bolus 5-FU. Despite the improvement in survival, postoperative therapies are associated with an approximately 35% incidence of grade 3+ toxicity. Recent data suggest that the use of preoperative combined modality therapy may be associated with less toxicity as well as increase the chance of sphincter preservation. New Intergroup trials addressing these issues will be presented. In patients with locally advanced unresectable rectal cancer, the addition of intraoperative radiation therapy may further improve local control. 3. Anal cancer. The use of combined 5-FU/Mitomycin-C and pelvic radiation therapy is effective in the treatment of anal carcinoma. The RTOG has recently completed a randomized trial addressing the question of the effectiveness and toxicity of Mitomycin-C. The replacement Intergroup Phase III trial will be presented

  8. Malignant priapism: a case report.

    LENUS (Irish Health Repository)

    Ellanti, P

    2011-12-01

    Metastatic involvement of the penis is most commonly from a primary malignant genitourinary tumour. It is a rare phenomenon usually reflecting disseminated malignancy associated with a poor prognosis. Metastasis to the penis mimicking priapism is extremely rare, particularly in the absence of disseminated disease.

  9. Malign katatoni, et neuropsykiatrisk syndrom

    DEFF Research Database (Denmark)

    Moltke, Katinka; Lublin, Henrik

    2010-01-01

    This case report describes a 36-year-old schizophrenic man who developed malignant catatonia during a hospital stay. He was treated with benzodiazepines (BZD) and 26 sessions of electroconvulsive therapy (ECT). After the therapy his condition normalised. Malignant catatonia is a rare condition that...

  10. Vibration damage testing of thermal barrier fibrous blanket insulation

    International Nuclear Information System (INIS)

    GA Technologies is engaged in a long-term, multiphase program to determine the vibration characteristics of thermal barrier components leading to qualification of assemblies for High Temperature Gas-Cooled Reactor (HTGR) service. The phase of primary emphasis described herein is the third in a series of acoustic tests and uses as background the more elemental tests preceding it. Two sizes of thermal barrier coverplates with one fibrous blanket insulation type were tested in an acoustic environment at sound pressure levels up to 160 dB. Three tests were conducted using sinusoidal and random noise for up to 200 h duration at room temperature. Frequent inspections were made to determine the progression of degradation using definition of stages from a prior test program. Initially the insulation surface adjacent to the metallic seal sheets (noise side) assumed a chafed or polished appearance. This was followed by flattening of the as-received pillowed surface. This stage was followed by a depression being formed in the vicinity of the free edge of the coverplate. Next, loose powder from within the blanket and from fiber erosion accumulated in the depression. Prior experience showed that the next stage of deterioration exhibited a consolidation of the powder to form a local crust. In this test series, this last stage generally failed to materialize. Instead, surface holes generated by solid ceramic particulates (commonly referred to as 'shot') constituted the stage following powdering. With the exception of some manufacturing-induced anomalies, the final stage, namely, gross fiber breakup, did not occur. It is this last stage that must be prevented for the thermal barrier to maintain its integrity. (orig./GL)

  11. FIBROUS MONOLITH WEAR RESISTANT COMPONENTS FOR THE MINING INDUSTRY

    Energy Technology Data Exchange (ETDEWEB)

    Mark J. Rigali; Mike L. Fulcher

    2003-03-25

    During the reporting period, work continued on development of formulations using the materials down-selected from the initially identified contenders for the fibrous monolith wear resistant components. In the previous reporting period, a two-stage binder removal process was developed that resulted in prototype parts free of voids and other internal defects. During the current reporting period, work was performed to characterize the two-stage binder removal process for WC-Co based FM material systems. Use of this process has resulted in the fabrication of defect free sintered WC-Co FM bodies, with minimal free carbon porosity and densities approaching 100% theoretical. With the elimination of free carbon porosity and other binder removal process related defects, development work focused on optimizing the densification and eliminating defects observed in WC-Co based FM consolidated by pressureless sintering. Shrinkage of the monolithic core and shell materials used in the WC-Co based FM system was measured, and differences in material shrinkage were identified as a potential cause of cell boundary cracking observed in sintered parts. Re-formulation of material blends for this system was begun, with the goal of eliminating mechanical stresses during sintering by matching the volumetric shrinkage of the core and shell materials. Thirty-three 7/8 inch drill bit inserts (WC-Co(6%)/WC-Co(16%) FM) were hot pressed during the reporting period. Six of these inserts were delivered for field-testing by Superior Rock Bit during the upcoming reporting period. In addition, Al{sub 2}O{sub 3}/Al{sub 2}O{sub 3}-TiCN FM cutting tool inserts were fabricated, and cutting tests performed.

  12. STRENGTH AND DEFORMABILITY OF STRUCTURAL ELEMENTS OF TRANSPORT FACILITIES ON THE BASIS OF FINE-GRAINED FIBROUS STEEL SLAG CONCRETE

    Directory of Open Access Journals (Sweden)

    R. N. Chernousov

    2011-11-01

    Full Text Available Problem statement. Application of steel fibrous concrete in structures of transport facilities providesfor their reliable and durable operation, however, along with the indisputable advantages,steel fibrous concrete has significant drawback. Its application in transport construction is very expensive.The use of cast slag crushed stone screenings, along with fibers from waste products oflocal factories, as a filler of concrete matrix will significantly reduce the costs of production oftransport facility structures and their elements with the use of steel fibrous concrete.Results and conclusions. According to the results of experimental studies formulae for practical estimationof shrinkage deformations of concrete matrix of fibrous steel slag concrete are obtained. Theanalytical relationships for fibrous steel slag concrete are derived. These relationships involve ultimatecompression and tensile strength, increase in compression and bending strength with time, longtermcompression strength, low cycle tensile fatigue, wearability. Based on experimental studies theuse of fibrous steel slag concrete in structural elements of transport facilities is suggested.

  13. Electrospun fibrous mats on lithographically micropatterned collectors to control cellular behaviors.

    Science.gov (United States)

    Liu, Yaowen; Zhang, Lei; Li, Huinan; Yan, Shili; Yu, Junsheng; Weng, Jie; Li, Xiaohong

    2012-12-11

    Spatial arrangement of multiple cell types plays a critical role in maintaining the viability of cells and functionality of tissues. Micropatterning has been used to fabricate scaffolds to modulate cell distribution, growth, and functions for reconstructing the anisotropy in native tissues. In the current study, a glass substrate patterned with an electrically conductive circuit was prepared by lithography as a collector for electrospinning. Densely packed fibers were deposited on the top of silver strips and patterned fibrous mats were obtained with distinct ridge and groove areas. Orthogonal alignment was shown for fibers in the ridge and groove areas, and the pattern feature and fiber alignment were well maintained in the ridge during incubation of cells with patterned fibrous mats. Sequential confocal laser scanning from the top of cell-loaded fibrous mats indicated that a larger number of cells were spread in the ridge than that in the groove areas, and cells penetrated into the fibrous mats in the ridge. Microscopic observation and immunofluorescent staining indicated that cells and collagen deposition appeared to have distinct patterns on the fibrous scaffold and aligned along the directionality of fibers with an elongated morphology. It is concluded that lithography can provide the design flexibility of collectors with micrometer-scale precision patterning, and cells can be confined to precise locations, sizes, and shapes by the use of micropatterned fibrous scaffolds without any adverse effect on the cell viability and function. The results suggest the potential of patterned electrospun fibrous mats to construct complex tissues of well organized multiple cell types and with spatially distributed extracellular matrices. PMID:23153038

  14. Malignant eroticized countertransference.

    Science.gov (United States)

    Chessick, R D

    1997-01-01

    Gabbard (1994) divided the pathology of therapists, both male and female, who commit sexual boundary violations into those who are psychotic, those who are predatory psychopaths, those engaging in masochistic surrender, and those called "the lovesick therapist." Lovesick therapists are the most common type and manifest crucial narcissistic themes of "a desperate need for validation by their patients, a hunger to be loved and idealized, and a tendency to use patients to regulate their own self-esteem" (p. 127). Among the psychodynamic aspects of this curiously circumscribed area of loss of reality testing that makes it difficult for the therapist to see how self-destructive and harmful such enactment is, are an unconscious reenactment of incestuous longings, a misperception of the patient's wish for maternal nurturance as a sexual overture, enactments of rescue fantasies, a projected idealization of the self of the therapist, a confusion of the therapist's needs with the patient's needs, a fantasy that love is curative, acting out disavowed rage at the patient, or rage at an organization, an institute, or one's training analyst, a manic defense against mourning, a narcissistic fantasy that their sexual affair is an exception, insecurity regarding masculine identity, and assorted primitive preoedipal themes. Gabbard's (1991) erotized countertransference is one variety of what I have termed malignant eroticized countertransference. His variety is a development that occurs under the pressure of the patient's preemptive and compelling expressions of lust and love, the patient's erotic transference. But malignant eroticized countertransference can also occur without the patient having offered any such expressions; it can even occur on first meeting the patient when he or she walks into the office! This is akin to the romantic "love-at-first-sight" theme so favored in the movies and by novelists, but it is always pathological when it occurs in the therapeutic situation. Countertransference enactments are a creation between the patient and the therapist on a continuum from one pole, where the patient has just walked into the office and contributes almost nothing directly, to the other pole, where the therapist loses control of himself or herself as a response to the unbearable pressure of the patient's lust. In the treatment of malignant eroticized countertransference it seems clear from this discussion that every case should be evaluated psychodynamically and the treatment should be made to fit the patient, not the patient to the treatment. Each situation should be studied in psychodynamic depth without preconceptions based on generalizations or formulas. Therapists who are psychotic should of course be treated with antipsychotic drugs and usually should not be allowed to practice any further. Therapists who are psychopathic or sociopathic predators should certainly never be allowed to practice. Some of the individuals who are "lovesick," or, as I put it "love/lust obsessed," or those who have made a masochistic surrender to a sadistic destructive patient, are in need of reanalysis and have the potential to continue as effective therapists under careful supervision. Therapists like this do not deserve to be summarily dismissed from the profession but, like therapists who develop other serious neurotic problems, should receive appropriate help from us. PMID:9395991

  15. [Malignant peritoneal mesothelioma].

    Science.gov (United States)

    Torrej贸n Reyes, Paul N; Frisancho, Oscar; G贸mez, Aldo; Y谩bar, Alejandro

    2010-01-01

    The peritoneal mesothelioma is a rare pathology with unspecific symptoms reason to be a difficult diagnosis. We report a case of a 58 year old man with diabetes mellitus type 2, arterial hypertension and smoking; without precedent of asbestos exposure. The patient presented a one month history characterized by progressive increase of the abdominal volume and sensation of fullness; three weeks later they added breathlessness and hyporexia. The patient was in regular general condition; he was not presenting hepatic stigmas, edema or adenomegalies. The examination of thorax and cardiovascular it was normal. The abdomen distended by ascites, not painful, liver and spleen not examined. Laboratory: Hemoglobin 11,9 gr/dl, WBC 6840/mm3 Bands 1 %, lymphocytes 10 %, platelets 620000/mm3, PT 12 seconds, PTT 34 seconds, glucose 158 mg/dl, BUN 20,5 mg/ dl, creatinine 1,2 mg/dl, proteins 6,1 gr/dl, albumin 2,6 gr/dl. LDH 316 U/l, beta2microglobulin 2,2 mg/l (0.83-1.15 mg/l). HBV and HCV negative. Ca 19.9, CEA, AFP and PSA negative. Hemocultive negative. Ascitic fluid: ADA 20,3 U/l, serum-ascitic albumin gradient (SAAG) 1,1. Leukocytes 2237 cells/mm3, PMN 6 %, lymphocytes 90 %, mesothelial cells 4 %, proteins 4,6 gr/dl, albumin 2,34 gr/dl, glucose 44 mg/dl, LDH 1918 U/l. Gram and cultive: negatives. BAAR and cultive: negative . Cytology: mesothelial cells with changes of type reagent, Block cell for tumour cells: negative. Abdominal US: increased peritoneum and abundant ascitic fluid. Thoracic-abdominal CT: left side pleural effusion, severe ascites with thick epyplon. Upper GI endoscopy: moderate gastritis. Colonoscopy: two small sessile polyps in sigmoid colon. The finds of the laparoscopy were interpreted like carcinomatosis or peritoneal tuberculosis. The report of the peritoneal biopsy was informed as suggestive of undifferentiated carcinoma; the reappraisal with inmunohystochemic (calretinin +,cytokeratin +, vimentin +) indicated malignant peritoneal mesothelioma, type epithelial. The evolution was torpid. The patient was transferred to the Service of Oncology where they initiated chemotherapy with Cysplatin (CDDP) and died 20 days later. The malignant mesothelioma peritoneal is a unfrequent entity, with limited therapeutic options; generally detected late, with a palliative treatment. PMID:20445731

  16. RARE METASTASES OF MALIGNANT MELANOMA

    Directory of Open Access Journals (Sweden)

    Marija Trenki?-Bo瀒novi?

    2014-09-01

    Full Text Available Melanomas are malignant neoplasms that originate from melanocytes. The most common are on the skin and mucous membranes. Choroidal melanomas are quite different from cutaneous melanomas with regard to presentation, metastases, and treatment. We report two cases of metastatic gastric malignant melanoma of the eye and skin, with reference to the literature. The first patient was a woman aged 23 years, who underwent gastrectomy 22 months after enucleation of the eye due to malignant choroid melanoma. The second patient was a man, 72 years old, who underwent surgery 28 months before because of malignant melanoma of the skin of the forehead. Paraffin sections, 4 ?m thick were stained using a classic method, as well as immunohistochemical DAKO APAAP method, using a specific S - 100 antibody and Melan A antibodies. The stomach is considered a rare place for the development of metastases. Metastases in the stomach are often limited to the submucosal as well as the serousmuscular layer, as noted in one of our patients. Metastatic melanoma of the gastrointestinal tract should be suspected in any patient with a history of malignant melanoma and new gastrointestinal symptoms. Because of the similarity between certain common histopathological types of malignant melanoma, primarily achromatic, and types of primary cancers of the stomach, the following immunohistochemical studies are needed: Melan A and S - 100 protein ( markers of malignant melanoma , as well as mucins: MUC5AC, MUC2 and CDX2 ( markers of different types of primary gastric carcinoma.

  17. Skin changes in internal malignancy

    Directory of Open Access Journals (Sweden)

    Rajagopal Ravi

    2004-07-01

    Full Text Available BACKGROUND: Internal malignancies are accompanied by various skin changes which may be specific infiltrates or non-specific changes. This study is aimed at determining the frequency of such changes in malignant disease treatment center attendees in India. METHODS: A study of 300 confirmed cases of internal malignancy at a malignant disease treatment center was undertaken to evaluate these skin changes. Specific infiltrates were confirmed by histopathology. Statistical methods were employed to calculate significance in non-specific lesions by comparing with 300 controls not suffering from internal malignancy. RESULTS: Skin changes were present in 82 (27.3%. Cutaneous metastases were found in 19 (6.3%; non-contiguous in 5 (1.6%; contiguous in 14 (4.3%. Non-specific skin lesions numbered 74 (11.6% in 52 patients. Statistically significant non-specific skin changes were acquired ichthyosis, herpes zoster and generalized pruritus. CONCLUSION: Metastases usually occurred late in internal malignancy (17, 5.6% except in a case each of histiocytic lymphoma and non-Hodgkin鈥瞫 lymphoma (2, 0.7% where the lesions preceded malignancy by 3 months and 1 month respectively. Contiguous nodules were a marker of relapse after surgery in 3 (1%.

  18. Benign Versus Malignant Compression Fractures

    Directory of Open Access Journals (Sweden)

    Babak Sanei

    2009-01-01

    Full Text Available 聽 "nSpinal compression fractures are common and may occur as a result of benign or malignant processes. Benign compression fractures may occur as a result of trauma, osteoporosis, Paget鈥檚 disease, other metabolic diseases, infection (especially atypical infections which may not involve the disk space, eosinophilic granuloma and benign primary bone tumors such as hemangioma. Malignant compression fractures are most commonly encountered as a result of metastatic disease, multiple myeloma which is the most common primary bone tumor and leukemia. Rarely, malignant compression fractures occur as a result of other malignant primary bone tumors. "nDifferentiation of malignant and benign compression fractures may be challenging. Both clinical findings and different imaging techniques are used for differentiation. This may be particularly difficult in elderly patients who are predisposed to benign compression fractures caused by osteoporosis. In this group benign fracture may result from minor trauma and can make the interpretation of the lesion difficult, if there is a known primary malignancy elsewhere. Establishing the correct diagnosis is of great importance in determining treatment and prognosis. In many instances biopsy and tissue diagnosis are necessary for the final diagnosis. The following imaging techniques are utilized in the evaluation of benign and malignant spinal compression fractures: radiography, computed tomography (CT, magnetic resonance imaging (MRI, bone scintigraphy, positron emission tomography (FDG-PET and PET-CT. 聽

  19. Malignancy and chronic renal failure.

    Science.gov (United States)

    Peces, Ramon

    2003-01-01

    Increased incidence of cancer at various sites is observed in patients with end-stage renal disease (ESRD). Certain malignant diseases, such as lymphomas and carcinomas of the kidney, prostate, liver and uterus, show an enhanced prevalence compared with the general population. In particular, renal cell carcinoma (RCC) shows an excess incidence in ESRD patients. A multitude of factors, directly or indirectly associated with the renal disease and the treatment regimens, may contribute to the increased tumor formation in these patients. Patients undergoing renal replacement therapy (RRT) are prone to develop acquired cystic kidney disease (ACKD), which may subsequently lead to the development of RCC. In pre-dialysis patients with coexistent renal disease, as in dialysis and transplant patients, the presence of ACKD may predispose to RCC. Previous use of cytotoxic drugs (eg, cyclophosphamide) or a history of analgesic abuse, are additional risk factors for malignancy. Malignancy following renal transplantation is an important medical problem during the follow-up. The most common malignancies are lymphoproliferative disorders (early after transplantation) and skin carcinomas (late after transplantation). Another important confounder for risk of malignancy after renal transplantation is the type of immunosuppression. The type of malignancy is different in various countries and dependent on genetic and environmental factors. Finally, previous cancer treatment in a uremic patient on the transplant waiting list is of great importance in relation to waiting time and post-malignancy screening. PMID:17657083

  20. Preparation of poly(ethylene glycol/polylactide hybrid fibrous scaffolds for bone tissue engineering

    Directory of Open Access Journals (Sweden)

    Ni P

    2011-11-01

    Full Text Available PeiYan Ni, ShaoZhi Fu, Min Fan, Gang Guo, Shuai Shi, JinRong Peng, Feng Luo, ZhiYong QianState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People's Republic of ChinaAbstract: Polylactide (PLA electrospun fibers have been reported as a scaffold for bone tissue engineering application, however, the great hydrophobicity limits its broad application. In this study, the hybrid amphiphilic poly(ethylene glycol (PEG/hydrophobic PLA fibrous scaffolds exhibited improved morphology with regular and continuous fibers compared to corresponding blank PLA fiber mats. The prepared PEG/PLA fibrous scaffolds favored mesenchymal stem cell (MSC attachment and proliferation by providing an interconnected porous extracellular environment. Meanwhile, MSCs can penetrate into the fibrous scaffold through the interstitial pores and integrate well with the surrounding fibers, which is very important for favorable application in tissue engineering. More importantly, the electrospun hybrid PEG/PLA fibrous scaffolds can enhance MSCs to differentiate into bone-associated cells by comprehensively evaluating the representative markers of the osteogenic procedure with messenger ribonucleic acid quantitation and protein analysis. MSCs on the PEG/PLA fibrous scaffolds presented better differentiation potential with higher messenger ribonucleic acid expression of the earliest osteogenic marker Cbfa-1 and mid-stage osteogenic marker Col I. The significantly higher alkaline phosphatase activity of the PEG/PLA fibrous scaffolds indicated that these can enhance the differentiation of MSCs into osteoblast-like cells. Furthermore, the higher messenger ribonucleic acid level of the late osteogenic differentiation markers OCN (osteocalcin and OPN (osteopontin, accompanied by the positive Alizarin red S staining, showed better maturation of osteogenic induction on the PEG/PLA fibrous scaffolds at the mineralization stage of differentiation. After transplantation into the thigh muscle pouches of rats, and evaluating the inflammatory cells surrounding the scaffolds and the physiological characteristics of the surrounding tissues, the PEG/PLA scaffolds presented good biocompatibility. Based on the good cellular response and excellent osteogenic potential in vitro, as well as the biocompatibility with the surrounding tissues in vivo, the electrospun PEG/PLA fibrous scaffolds could be one of the most promising candidates in bone tissue engineering.Keywords: electrospinning, fibrous scaffolds, poly(ethylene glycol/polylactide, mesenchymal stem cells, bone tissue engineering

  1. [Neuroleptic malignant syndrome].

    Science.gov (United States)

    Chodorowski, Zygmunt; Anand, Jacek Sein; Rutkowski, Przemys?aw

    2003-01-01

    Neuroleptic malignant syndrome (NMS) is the most dangerous side effect of phenothiazines therapy. In the period of time from 1995 to 2002 in the Intensive Toxicological Unit there were five patients, 3 men and 2 women, aged from 25 to 62 (average 44.2) years-old, admitted from the regional inpatients psychiatric units with the diagnosis of pneumonia and/or sepsis. The patients about 48-72 hours before admittance were given some phenotiazine derivatives (promazine, perphenazine, clozapine, pipamperon) and/or buthyrophenone (haloperidol) because of psychotic state. Altered consciousness, muscle rigidity, hyperpyrexia (39.0-41.0 degrees C), sweating, tachycardia (120-150/min.), tachypnoea (respiratory rate more than 25/min.) and high level of creatine kinase activity (23,751-112,288 U/l) dominated. Only one patient had clinical picture of pneumonia. Because of the rapid development of acute respiratory failure, respirathorotherapy was initiated and continued for 8 and 10 days in two patients respectively. Transient thrombocytopenia (26,000/microliter) in one subject was observed. The neuroleptic drug was withdrawn and intensive supportive care with administration of bromocriptine (15-20 mg/24 h) was provided. None one of the doctors told the patients about the possibility of NMS during phenothiazines therapy. PMID:14569909

  2. Childhood ovarian malignancy.

    Science.gov (United States)

    Mahadik, Kalpana; Ghorpade, Kanchanmala

    2014-04-01

    Objective of this article is to appraise diagnostic aspects and treatment modalities in childhood ovarian tumor in background of available evidence. Literature search on Pubmed revealed various aspects of epidemiology, histopathological diagnosis, and treatment of pediatric ovarian tumor. 85% of childhood tumors are germ cell tumors. The varied histopathological picture in germ cell tumors poses a diagnostic and therapeutic challenge. Immunohistochemistry and newer genetic markers like SALL4 and karyopherin-2 (KPNA2) have been helpful in differentiating ovarian yolk sac tumor from dysgerminoma, teratomas, and other pictures of hepatoid, endometrioid, clear cell carcinomatous, and adenocarcinomatous tissues with varied malignant potential. Before platinum therapy, these tumors were almost fatal in children. Fertility-conserving surgery with bleomycin, etoposide, and cisplatin has dramatically changed the survival rates in these patients. This modality gives cancer cure with healthy offspring to female patients with childhood ovarian tumor. Evidence also supports this protocol resulting in successful pregnancy rates and safety of cytotoxic drugs in children born to these patients. PMID:24757335

  3. Evaluation of sodium sulfite and protein correction in analyses of fibrous compounds in tropical forages

    Scientific Electronic Library Online (English)

    Daiany 蛂is, Gomes; Edenio, Detmann; Sebasti鉶 de Campos, Valadares Filho; Rafael, Mezzomo; Nat醠ia Krish de Paiva, Souza; Augusto C閟ar de, Queiroz; Kelly da Silva Coutinho, Detmann.

    2012-01-01

    Full Text Available The objective of this study was to evaluate the contents of fibrous compounds in tropical grasses and legumes according to utilization of sodium sulfite in the neutral detergent solution or using a procedure for contaminant protein correction. Samples of ten grasses and ten legumes were used. The co [...] ntents of neutral detergent fiber were decreased when sodium sulfite was used; however, more prominent reductions were verified in legumes. Sodium sulfite decreased the acid detergent fiber content in both forage groups. The contents of neutral and acid detergent insoluble protein and lignin were reduced by sodium sulfite in legumes, but no effect was observed in grasses with regard to these variables. The decrease in fiber contents in legumes could be explained by the solubilization of lignin and decrease in insoluble nitrogen. However, the decreases in fiber in grasses could not be solely explained by the decrease in contaminant protein and solubilization of lignin, and loss of other fibrous compounds probably occurred. The utilization of sodium sulfite compromises the accuracy of the estimates of fibrous compounds contents in tropical forages. The precision of the estimates were not relevantly increased by sodium sulfite. The correction of insoluble fibrous compounds for protein is suggested instead of using sodium sulfite because there are no modifications on neutral detergent solution or undesirable solubilization of fibrous compounds.

  4. Experimental investigation of sedimentation of LOCA - generated fibrous debris and sludge in BWR suppression pools

    International Nuclear Information System (INIS)

    Several tests were conducted in a 1:2.4 scale model of a Mark I suppression pool to investigate the behavior of fibrous insulation and sludge debris under LOCA conditions. NUKON trademark shreds, manually cut and tore up in a leaf shredder, and iron oxide particles were used to simulate fibrous and sludge debris, respectively. The suppression pool model included four downcomers fitted with pistons to simulate the steam-water oscillations during chugging expected during a LOCA. The study was conducted to provide debris settling velocity data for the models used in the BLOCKAGE computer code, developed to estimate the ECCS pump head loss due to clogging of the strainers with LOCA generated debris. The tests showed that the debris, both fibrous and particulate, remains fully mixed during chugging; they also showed that, during chugging, the fibrous debris underwent fragmentation into smaller sizes, including individual fibers. Measured concentrations showed that fibrous debris settled slower than the sludge, and that the settling behavior of each material is independent of the presence of the other material. Finally, these tests showed that the assumption of considering uniform debris concentration during strainer calculations is reasonable. The tests did not consider the effects of the operation of the ECCS on the transport of debris in the suppression pool

  5. Backscatter factor and absorption ratio of fibrous zirconia media in the visible

    International Nuclear Information System (INIS)

    Fibrous thermal insulations are widely used to conserve energy in ambient to high temperature applications including buildings, solar collectors, heat exchangers, furnaces and thermal protection systems of reusable launch vehicles. It has long been recognised that zirconia has the lowest thermal conductivity of commercial refractories. The thermal conductivity of a zirconia fibrous medium is strongly dependent of its bulk density; high bulk densities of zirconia fibers provide the most effective insulation at high temperatures. Lee's theory for radiative transfer through fibrous media is used in this paper. The two-flux model is applied to determine the backward and forward parameters of a medium of zirconia fibers oriented in parallel planes. Theoretical calculations of the backscatter factor and absorption ratio of this medium are carried out in the visible spectrum for different size parameters of the fibers and for three different temperatures. Our results show that the backscatter factor of zirconia fibrous insulations is maximum, and therefore the heat transfer by the fibrous medium is the lowest, for a size parameter of 0.45 for all the temperatures studied. We also observed that the backscatter factor decreases with increasing temperature. (author)

  6. Synthesis of precursor for fibrous mullite powder by alkoxide hydrolysis method

    International Nuclear Information System (INIS)

    Precursor for fibrous mullite powder was synthesized by simple alkoxide hydrolysis method without special treatment, and the formation mechanism of fibrous mullite precursor was investigated. As-synthesized precursor was amorphous and consisted of nano-scaled particles, and Al2O3 and SiO2 components containing small amount of Si-O-Al components existed in the precursor. During heat-treatment, Al-Si spinel phase and amorphous SiO2 formed around 1000 deg. C, and the products after heat-treatment above 1200 deg. C consisted of single mullite phase as fibrous shape of mullite precursor was maintained. In the present synthesis process, fibrous precursor derived from aluminum isopropoxide acted as a template for fibrous mullite precursor. Specific surface area of as-synthesized mullite precursor was 380 m2/g, and it gradually decreased with increasing heat-treatment temperature. Specific surface area of the products significantly decreased around 1200 deg. C, that corresponded to crystallization temperature, and that of the product after heat-treatment at 1300 deg. C was 13 m2/g.

  7. Creating Hierarchical Topographies on Fibrous Platforms Using Femtosecond Laser Ablation for Directing Myoblasts Behavior.

    Science.gov (United States)

    Jun, Indong; Chung, Yong-Woo; Heo, Yun-Hoe; Han, Hyung-Seop; Park, Jimin; Jeong, Hongsoo; Lee, Hyunjung; Lee, Yu Bin; Kim, Yu-Chan; Seok, Hyun-Kwang; Shin, Heungsoo; Jeon, Hojeong

    2016-02-10

    Developing an artificial extracellular matrix that closely mimics the native tissue microenvironment is important for use as both a cell culture platform for controlling cell fate and an in vitro model system for investigating the role of the cellular microenvironment. Electrospinning, one of the methods for fabricating structures that mimic the native ECM, is a promising technique for creating fibrous platforms. It is well-known that align or randomly distributed electrospun fibers provide cellular contact guidance in a single pattern. However, native tissues have hierarchical structures, i.e., topographies on the micro- and nanoscales, rather than a single structure. Thus, we fabricated randomly distributed nanofibrous (720 80 nm in diameter) platforms via a conventional electrospinning process, and then we generated microscale grooves using a femtosecond laser ablation process to develop engineered fibrous platforms with patterned hierarchical topographies. The engineered fibrous platforms can regulate cellular adhesive morphology, proliferation, and distinct distribution of focal adhesion proteins. Furthermore, confluent myoblasts cultured on the engineered fibrous platforms revealed that the direction of myotube assembly can be controlled. These results indicate that our engineered fibrous platforms may be useful tools in investigating the roles of nano- and microscale topographies in the communication between cells and ECM. PMID:26771693

  8. Optical reflectance in fibrous tissues and skeletal muscles

    Science.gov (United States)

    Ranasinghesagara, Janaka C.

    We studied two biological tissues with optically anisotropic structures: high moisture soy protein extrudates and skeletal muscles. High moisture extrusion has been used to produce vegetable meat analogs that resemble real animal meat and have significant health benefits. Since visual and textural properties are key factors for consumer acceptance, assessing fiber formation in the extruded soy protein product is important for quality control purpose. A non-destructive method based on photon migration was developed to measure fiber formation in extruded soy proteins. The measured fiber formation index in intact samples showed good agreement with that obtained from image analysis on peeled samples. By implementing this new method in a fast laser scanning system, we have acquired two dimensional mappings of fiber formation and orientation in the entire sample in real time. In addition to fibrous structures, skeletal muscles have a unique periodic sarcomere structure which produces strong light diffractions. However, inconsistent experimental results have been reported in single fiber diffraction studies. By applying the three-dimensional coupled wave theory in a physical sarcomere model, we found that a variety of experimental observations can be explained if inhomogeneous muscle morphological profiles are considered. We also discovered that the sarcomere structure produced a unique optical reflectance pattern in whole muscle. None of the existing light propagation theories are able to describe this pattern. We developed a Monte Carlo model incorporating the sarcomere diffraction effect. The simulated results quantitatively resemble the unique patterns observed in experiments. We used a set of parameters to quantify the optical reflectance profiles produced by a point incident light in whole muscle. Two parameters, q and B, were obtained by numerically fitting the equi-intensity contours of the reflectance pattern. Two spatial gradients were calculated along the directions parallel and perpendicular to muscle fibers. The mean diffuse intensity was obtained by excluding the specular reflectance. These five parameters provide a comprehensive and complete description of the diffuse reflectance in muscle. In a study of 336 muscle samples, we found these optical parameters were subject to the effects of different muscle physical and biochemical factors. Different types of muscle have significantly different diffuse intensities. Aging shows different effects on the q parameter in different muscles. In addition, the mean diffuse intensity is significantly different (p<0.05) in different animal breeds. Optical parameters showed good correlations with Warner-Bratzler shear force. Further studies on a large sample group are necessary to develop a statistical model to predict muscle physical and chemical properties using these non-destructive optical measurements.

  9. A New Approach to Fibrous Composite Laminate Strength Prediction

    Science.gov (United States)

    Hart-Smith, L. J.

    1990-01-01

    A method of predicting the strength of cross-plied fibrous composite laminates is based on expressing the classical maximum-shear-stress failure criterion for ductile metals in terms of strains. Starting with such a formulation for classical isotropic materials, the derivation is extended to orthotropic materials having a longitudinal axis of symmetry, to represent the fibers in a unidirectional composite lamina. The only modification needed to represent those same fibers with properties normalized to the lamina rather than fiber is a change in axial modulus. A mirror image is added to the strain-based lamina failure criterion for fiber-dominated failures to reflect the cutoffs due to the presence of orthogonal fibers. It is found that the combined failure envelope is now identical with the well-known maximum-strain failure model in the tension-tension and compression-compression quadrants but is truncated in the shear quadrants. The successive application of this simple failure model for fibers in the 0/90 degree and +/- 45 degree orientations, in turn, is shown to be the necessary and sufficient characterization of the fiber-dominated failures of laminates made from fibers having the same tensile and compressive strengths. When one such strength is greater than the other, the failure envelope is appropriately truncated for the lesser direct strain. The shear-failure cutoffs are now based on the higher axial strain to failure since they occur at lower strains than and are usually not affected by such mechanisms as microbuckling. Premature matrix failures can also be covered by appropriately truncating the fiber failure envelope. Matrix failures are excluded from consideration for conventional fiber/polymer composites but the additional features needed for a more rigorous analysis of exotic materials are covered. The new failure envelope is compared with published biaxial test data. The theory is developed for unnotched laminates but is easily shrunk to incorporate reductions to allow for bolt holes, cutouts, reduced compressive strength after impact, and the like.

  10. Drugs Approved for Malignant Mesothelioma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for malignant mesothelioma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  11. Dedifferentiated parosteal osteosarcoma with giant cell tumor component

    International Nuclear Information System (INIS)

    Dedifferentiated parosteal osteosarcoma is characterized histologically by the admixture of low-grade fibroblastic osteosarcoma and a high-grade component typically resembling conventional osteosarcoma or malignant fibrous histiocytoma. We report an unusual distal femoral dedifferentiated parosteal osteosarcoma in which the dedifferentiated component resembled a giant cell tumor of bone. This phenotype is rarely described in the dedifferentiated component of a dedifferentiated parosteal osteosarcoma. The clinical, radiographic, and pathologic features of this unusual tumor are described to further expand the histologic spectrum of dedifferentiated parosteal osteosarcoma. (orig.)

  12. Malignant hyperthermia: a review.

    Science.gov (United States)

    Rosenberg, Henry; Pollock, Neil; Schiemann, Anja; Bulger, Terasa; Stowell, Kathryn

    2015-01-01

    Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane, isoflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stressors such as vigorous exercise and heat. The incidence of MH reactions ranges from 1:10,000 to 1: 250,000 anesthetics. However, the prevalence of the genetic abnormalities may be as great as one in 400 individuals. MH affects humans, certain pig breeds, dogs and horses. The classic signs of MH include hyperthermia, tachycardia, tachypnea, increased carbon dioxide production, increased oxygen consumption, acidosis, hyperkalaemia, muscle rigidity, and rhabdomyolysis, all related to a hypermetabolic response. The syndrome is likely to be fatal if untreated. An increase in end-tidal carbon dioxide despite increased minute ventilation provides an early diagnostic clue. In humans the syndrome is inherited in an autosomal dominant pattern, while in pigs it is autosomal recessive. Uncontrolled rise of myoplasmic calcium, which activates biochemical processes related to muscle activation leads to the pathophysiologic changes. In most cases, the syndrome is caused by a defect in the ryanodine receptor. Over 400 variants have been identified in the RYR1 gene located on chromosome 19q13.1, and at least 34 are causal for MH. Less than 1% of variants have been found in CACNA1S but not all of these are causal. Diagnostic testing involves the in vitro contracture response of biopsied muscle to halothane, caffeine, and in some centres ryanodine and 4-chloro-m-cresol. Elucidation of the genetic changes has led to the introduction of DNA testing for susceptibility to MH. Dantrolene sodium is a specific antagonist and should be available wherever general anesthesia is administered. Increased understanding of the clinical manifestation and pathophysiology of the syndrome, has lead to the mortality decreasing from 80% thirty years ago to <5% in 2006. PMID:26238698

  13. Bile duct malignancies.

    Science.gov (United States)

    Tucek, S; Tomasek, J; Hal谩mkova, J; Kiss, I; Andrasina, T; Hemmelov谩, B; Ad谩mkov谩-Kr谩korov谩, D; Vyzula, R

    2010-01-01

    Bile duct malignancies include intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC), gall bladder carcinoma (GC) and carcinoma of Vater's ampulla (ampulloma). Bile duct neoplasms are rare tumours with overall poor prognosis. The overall incidence affects up to 12.5 per 100,000 persons in the Czech Republic. The mortality rate has risen recently to 9.5 per 100,000 persons. The incidence and mortality have been remarkably stable over the past 3 decades. The survival rate of patients with these tumours is poor, usually not exceeding 12 months. The diagnostic process is complex, uneasy and usually late. Most cases are diagnosed when unresectable, and palliative treatment is the main approach of medical care for these tumours. The treatment remains very challenging. New approaches have not brought much improvement in this field. Standards of palliative care are lacking and quality of life assessments are surprisingly not common. From the scarce data it seems, however, that multimodal individually tailored treatment can prolong patients'survival and improve the health-related quality of life. The care in specialized centres offers methods of surgery, interventional radiology, clinical oncology and high quality supportive care. These methods are discussed in the article in greater detail. Improvements in this field can be sought in new diagnostic methods and new procedures in surgery and interventional radiology. Understanding the tumour biology on the molecular level could shift the strategy to a more successful one, resulting in more cured patients. Further improvements in palliative care can be sought by defining new targets and new drug development. The lack of patients with bile duct neoplasms has been the limiting factor for any improvements. A new design of larger randomized international multicentric clinical trials with prompt data sharing could help to overcome this major problem. Defining standards of palliative care is a necessity. Addressing health-related quality of life could help to assess the real benefit of palliative treatment. PMID:20806821

  14. Superhydrophobic coating to delay drug release from drug-loaded electrospun fibrous materials

    Science.gov (United States)

    Song, Botao; Xu, Shichen; Shi, Suqing; Jia, Pengxiang; Xu, Qing; Hu, Gaoli; Zhang, Hongxin; Wang, Cuiyu

    2015-12-01

    The drug-loaded electrospun fibrous materials showed attractive applications in biomedical fields; however, the serve burst release of drug from this kind of drug carrier limited its further applications. In this study, inspired by water strong repellency of superhydrophobic surface, the drug-loaded electrospun fibrous mat coated with superhydrophobic layer was constructed to retard and control drug release. The results indicated that the superhydrophobic coating could be simply fabricated on the drug-loaded electrospun mat by the electrospray approach, and the thickness of the superhydrophobic coating could be finely controlled by varying the deposition time. It was further found that, as compared with drug-loaded electrospun mats, drug released sustainably from the samples coated with superhydrophobic layer, and the drug release rate could be controlled by the thickness of superhydrophobic layer. In summary, the current approach of coating a superhydrophobic layer on the drug-loaded electrospun fibrous materials offered a fundament for drug sustained release.

  15. Solitary fibrous tumor of the male breast: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Sessa Fausto

    2008-02-01

    Full Text Available Abstract Extrapleural solitary fibrous tumors are very rare and occasionally they appear in extraserosal soft tissues or parenchymatous organs. In such cases the right preoperative diagnosis is often difficult and challenging, because both radiological and cytological examinations are not exhaustive. For these reasons, surgical excision is frequently the only way to reach the correct diagnosis and to achieve definitive treatment. A few cases of solitary fibrous tumors have been also described in the breast. Although rare, this lesion opens difficulties in preoperative diagnosis entering in differential diagnosis with other benign lesions as well as with breast cancer. In this article we describe a case of a solitary fibrous tumor of the breast in a 49-year-old man. Problems related to differential diagnosis and the possible pitfalls that can be encountered in the diagnostic iter of such rare tumor are discussed.

  16. Micromechanics approach to the magnetoelectric properties of laminate and fibrous piezoelectric/magnetostrictive composites

    International Nuclear Information System (INIS)

    We use a micromechanics approach to study the magnetoelectric (ME) properties of the piezoelectric/magnetostrictive composite with a 2-2 laminate structure and a 3-1 fibrous structure. It is found that the 3-1 composite has a higher ME coefficient than the 2-2 one, if the volume ratio of piezoelectric material is the same. The reason is that the 3-1 fibrous composite makes use of the longitudinal piezoelectric response and the piezoelectric voltage constant g33 is 2-3 times that of g31. Generally, a smaller volume ratio of the piezoelectric material will generate a higher ME response. The tensile stress at the piezoelectric/magnetostrictive interface of the 3-1 fibrous composite, however, could be high enough to induce plastic deformation or microcracks, which leads to a ME coefficient lower than the theoretically predicted one

  17. A New Device for Characterisation of the Drainage Kinetics of Fibrous Suspensions Under Gravity

    Directory of Open Access Journals (Sweden)

    Przybysz Piotr

    2014-12-01

    Full Text Available Gravity dewatering of fibrous suspension is one of basic technological operations in paper production process. Although there are numerous methods to determine dewatering of such suspensions, none of them can measure undisturbed flow of removed water. In the paper the idea and design of a new apparatus for the determination of drainage rate of fibrous suspensions is presented. The apparatus differs from other known devices by minimisation of filtrate flow resistance in the outlet part of the equipment. In the second part of the paper measurements of the drainage rate have been presented. The flow resistance of the fluid through the bottom wire screen in the device was determined. The calculated flow resistance will be used in the developed model of dynamic drainage of fibrous suspensions, which will be discussed in our following paper (Przybysz et al., 2014.

  18. Highly efficient fibrous dye-sensitized solar cells based on TiO2 nanotube arrays

    International Nuclear Information System (INIS)

    The structure of fibrous dye-sensitized solar cells, which were constructed by a TiO2 nanotube array on Ti wire as the photoanode twisted by a Pt wire counter electrode, has been first systematically investigated by accurately controlling the thread pitch distance of screwed Pt wire. It has been revealed that the thread pitch will strongly influence the photovoltaic performance and kinetic processes in fibrous solar cells. The effect of the length of the TiO2 nanotube on cell performance has also been discussed. After optimization, a relatively universal optimized thread pitch value of 1 mm for fibrous DSCs has been proved and the light-to-electricity conversion efficiency has been remarkably improved to 5.84%.

  19. Cutaneous malignant melanoma in Scotland.

    OpenAIRE

    Mackie, R.M.; Hunter, J A

    1982-01-01

    In view of the concern over the rising incidence of malignant melanoma in many parts of the world, and the suggestion that emigrants of Scottish and Irish descent have a higher incidence of melanoma in North America and Australia, a Scottish Melanoma Group has been formed to study epidemiological, pathological and therapeutic aspects of the tumour. In 1979, 260 histologically proven primary cutaneous malignant melanomas of the skin presented. This represents an incidence of 5.1/10(5) for Scot...

  20. Malignant Peripheral Nerve Sheath Tumors

    OpenAIRE

    Farid, Mohamad; Demicco, Elizabeth G.; Garcia, Roberto; Ahn, Linda; Merola, Pamela R.; Cioffi, Angela; Maki, Robert G.

    2014-01-01

    Malignant peripheral nerve sheath tumors are amongst the most challenging mesenchymal malignancies to treat. Their frequent association with a seemingly simple genetic aberration梩he loss of the tumor suppressor gene neurofibromin梑elies genomic complexity that has rendered effective therapy elusive to date. This review aims to detail elements of current optimal clinical management and summarize recent data on potential molecular drivers and targets, with a view to charting the course for fut...

  1. H氓ndens maligne tumorer

    DEFF Research Database (Denmark)

    Knudsen, Britt Mejer; Rasmussen, Per Joen Svabo; Lausten, Gunnar Schwarz; Jensen, Nina Vendel; Nielsen, Niels S酶e

    2011-01-01

    Malignant tumours of the hand are rare and are often misdiagnosed. A painful swelling of the hand or digits are often diagnosed with an infection, benign tumours such as ganglion cysts, or arthritis. Wounds that do not heal despite adequate treatment should be biopsied to rule out malignancy. A...... correct diagnosis without delay is important because the life expectancy, due to a metastasis on the hand or fingers is approximately six months....

  2. Malignant schwannoma of the rectum

    International Nuclear Information System (INIS)

    Malignant schwannomas are rare. These malignomas are primary nerve sheath tumors that usually arise from a peripheral nerve. They appear most frequently in the lower extremities, including the hips and buttocks (34.8%), the upper extremities (23.4%), and in the trunk (17%). To the best of our knowledge, this is the first reported case of a malignant schwannoma of the rectum. We describe the rare disease with reference to the literature. (orig.)

  3. Water-stable three-dimensional ultrafine fibrous scaffolds from keratin for cartilage tissue engineering.

    Science.gov (United States)

    Xu, Helan; Cai, Shaobo; Xu, Lan; Yang, Yiqi

    2014-07-22

    Intrinsically water-stable scaffolds composed of ultrafine keratin fibers oriented randomly and evenly in three dimensions were electrospun for cartilage tissue engineering. Keratin has been recognized as a biomaterial that could substantially support the growth and development of multiple cell lines. Besides, three-dimensional (3D) ultrafine fibrous structures were preferred in tissue engineering due to their structural similarity to native extracellular matrices in soft tissues. Recently, we have developed a nontraditional approach to developing 3D fibrous scaffolds from alcohol-soluble corn protein, zein, and verified their structural advantages in tissue engineering. However, keratin with highly cross-linked molecular structures could not be readily dissolved in common solvents for fiber spinning, which required the remarkable drawability of solution. So far, 3D fibrous scaffolds from pure keratin for biomedical applications have not been reported. In this research, the highly cross-linked keratin from chicken feathers was de-cross-linked and disentangled into linear and aligned molecules with preserved molecular weights, forming highly stretchable spinning dope. The solution was readily electrospun into scaffolds with ultrafine keratin fibers oriented randomly in three dimensions. Due to the highly cross-linked molecular structures, keratin scaffolds showed intrinsic water stability. Adipose-derived mesenchymal stem cells could penetrate much deeper, proliferate, and chondrogenically differentiate remarkably better on the 3D keratin scaffolds than on 2D PLA fibrous scaffolds, 3D soy protein fibrous scaffolds, or 3D commercial nonfibrous scaffolds. In summary, the electrospun 3D ultrafine fibrous scaffolds from keratin could be promising candidates for cartilage tissue engineering. PMID:25010870

  4. Electrospun PVdF-based fibrous polymer electrolytes for lithium ion polymer batteries

    International Nuclear Information System (INIS)

    This paper discusses the preparation of microporous fibrous membranes from PVdF solutions with different polymer contents, using the electrospinning technique. Electrospun PVdF-based fibrous membranes with average fiber diameters (AFD's) of 0.45-1.38 ?m have an apparent porosity and a mean pore size (MPS) of 80-89% and 1.1-4.3 ?m, respectively. They exhibited a high uptake of the electrolyte solution (320-350%) and a high ionic conductivity of above 1 x 10-3 s/cm at room temperature. Their ionic conductivity increased with the decrease in the AFD of the fibrous membrane due to its high electrolyte uptake. The interaction between the electrolyte molecules and the PVdF with a high crystalline content may have had a minor effect on the lithium ion transfer in the fibrous polymer electrolyte, unlike in a nanoporous gel polymer electrolyte. The fibrous polymer electrolyte that contained a 1 M LiPF6-EC/DMC/DEC (1/1/1 by weight) solution showed a high electrochemical stability of above 5.0 V, which increased with the decrease in the AFD The interfacial resistance (Ri) between the polymer electrolyte and the lithium electrode slightly increased with the storage time, compared with the higher increase in the interfacial resistance of other gel polymer electrolytes. The prototype cell (MCMB/PVdF-based fibrous electrolyte/LiCoO2) showed a very stable charge-discharge behavior with a slight capacity loss under constant current and voltage conditions at the C/2-rate of 20 and 60 deg. C

  5. Primary Solitary Fibrous Tumor of the Thyroid - Report of a Case and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Zhigang Song, Chunkai Yu, Xin Song, Lixin Wei, Aijun Liu

    2011-01-01

    Full Text Available Solitary fibrous tumor (SFT is a rare spindle-cell neoplasm, especially in the thyroid. We report a case of primary solitary fibrous tumor of the thyroid gland in a 37 year-old Chinese man. The tumor was characterized by bland-looking spindle cells admixed with thin and thick collagen fibers. On immunohistochemistry study indicated that tumor cells were diffusely positive for CD34, Bcl-2 and CD99, and negative for Desmin, NSE, SMA, S-100, and CD68. The patient remains well 16 months after excision. The morphologic and immunohistochemical features of the thyroid SFTs are similar to their reported counterparts in other anatomic sites.

  6. Filtration efficiency of an electrostatic fibrous filter: Studying filtration dependency on ultrafine particle exposure and composition

    DEFF Research Database (Denmark)

    Ardkapan, Siamak Rahimi; Johnson, Matthew S.; Yazdi, Sadegh; Afshari, Alireza; Bergs酶e, Niels C.

    2014-01-01

    The objective of the present study is to investigate the relationship between ultrafine particle concentrations and removal efficiencies for an electrostatic fibrous filter in a laboratory environment. Electrostatic fibrous filters capture particles efficiently, with a low pressure drop. Therefore...... controlled laboratory environment using two different particle counters: a Scanning Mobility Particle Sizer and a NanoTracer. Particles were generated at different concentrations by burning a pure wax candle in a test room. The set-up consisted of a test room, a fan a duct and the particle filter. The...

  7. An Investigation of the Radiative Heat Transfer through Nonwoven Fibrous Materials

    OpenAIRE

    Imad Qashou; Hooman Vahedi Tafreshi; Behnam Pourdeyhimi

    2009-01-01

    In this study, the surface-to-surface radiation model of the Fluent CFD code is used to investigate the response of a fibrous material to the radiative heat transfer. The unsteady state heat transfer equation is solved for the temperature and heat flux in and around the fibers that constitute a nonwoven fibrous material. For a fixed fiber diameter, it was shown that the higher the fabric鈥檚 Solid Volume Fraction (SVF), the slower is the material鈥檚 average temperature rise. Our simulation resul...

  8. Nitridated fibrous silica (KCC-1) as a sustainable solid base nanocatalyst

    KAUST Repository

    Bouhrara, Mohamed

    2013-09-03

    We observed that support morphology has dramatic effects on the performance of nitridated silica as a base. By simply replacing conventional silica supports (such as SBA-15 and MCM-41) with fibrous nanosilica (KCC-1), we observed multifold enhancement in the catalytic activity of the nitridated solid base for Knoevenagel condensations and transesterification reactions. This enhancement of the activity can be explained by amine accessibility, which is excellent in KCC-1 due to its open and flexible fibrous structure, that facilitates penetration and interaction with basic amine sites. 漏 2013 American Chemical Society.

  9. Fibrous Dysplasia in a 120,000+ Year Old Neandertal from Krapina, Croatia

    OpenAIRE

    Monge, Janet; Kricun, Morrie; Radov膷i膰, Jakov; Radov膷i膰, Davorka; Mann, Alan; Frayer, David W.

    2013-01-01

    We describe the first definitive case of a fibrous dysplastic neoplasm in a Neandertal rib (120.71) from the site of Krapina in present-day Croatia. The tumor predates other evidence for these kinds of tumor by well over 100,000 years. Tumors of any sort are a rare occurrence in recent archaeological periods or in living primates, but especially in the human fossil record. Several studies have surveyed bone diseases in past human populations and living primates and fibrous dysplasias occur in...

  10. Fibrous Support Stabilizes Nitrification Performance of a Membrane-Aerated Biofilm: The Effect of Liquid Flow Perturbation

    DEFF Research Database (Denmark)

    Terada, Akihiko; Ito, J; Matsumoto, S; Tsuneda, S

    2009-01-01

    Nitrification stability and biofilm robustness were examined by comparing a fibrous support membrane-aerated biofilm reactor (FS-MABR), where a woven fibrous support was surrounded on a silicone tube, with an MABR. The overall mass transfer coefficient of oxygen for the FS-MABR, assuming no bound...

  11. Case report: fibrous dysplasia of the navicular bone treated with excision of navicular and talo-cuneiform arthrodesis.

    Science.gov (United States)

    Siu, W; Ferguson, K B; Kumar, C S; Mahendra, A

    2015-03-01

    Fibrous dysplasia is an uncommon beningn disorder of bone. It usually affects the long bones, and is uncommon in the navicular. We describe a case of fibrous dysplasia of the navicular successfully treated with navicular excision and talo-cuneiform arthrodesis. PMID:25542678

  12. Antibacterial and anti-adhesion effects of the silver nanoparticles-loaded poly(L-lactide) fibrous membrane

    International Nuclear Information System (INIS)

    The complications of tendon injury are frequently compromised by peritendinous adhesions and tendon sheath infection. Physical barriers for anti-adhesion may increase the incidence of postoperative infection. This study was designed to evaluate the potential of silver nanoparticles (AgNPs)-loaded poly(L-lactide) (PLLA) electrospun fibrous membranes to prevent adhesion formation and infection. Results of an in vitro drug release study showed that a burst release was followed by sustained release from electrospun fibrous membranes with a high initial silver content. Fewer fibroblasts adhered to and proliferated on the AgNP-loaded PLLA electrospun fibrous membranes compared with pure PLLA electrospun fibrous membrane. In the antibacterial test, the AgNP-loaded PLLA electrospun fibrous membranes can prevent the adhesion of Gram-positive Staphylococcus aureus and Staphylococcus epidermidis and Gram-negative Pseudomonas aeruginosa. Taken together, these results demonstrate that AgNP-loaded PLLA electrospun fibrous membranes have the convenient practical medical potential of reduction of infection and adhesion formation after tendon injury. - Highlights: 鈻 Silver nanoparticles are directly electrospun into PLLA fibrous membrane. 鈻 Long-lasting release of Ag + ions is achieved. 鈻 Cytotoxicity of silver ions benefits the anti-proliferation of physical barriers. 鈻 Broad anti-microbial effect of drug-loaded fibrous membrane is revealed. 鈻 Antibacterial and anti-adhesion effects of the physical barriers are combined

  13. Antibacterial and anti-adhesion effects of the silver nanoparticles-loaded poly(L-lactide) fibrous membrane

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Shen [Department of Orthopaedics, Shanghai Sixth People' s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233 (China); Zhao, Jingwen [Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215007 (China); School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030 (China); Ruan, Hongjiang; Wang, Wei [Department of Orthopaedics, Shanghai Sixth People' s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233 (China); Wu, Tianyi [Department of Orthopaedic Surgery, 2nd Affiliated hospital of Nanjing Medical University, Nanjing Medical University, 121 Jiang Jia Yuan, Nanjing 210011 (China); Cui, Wenguo, E-mail: wgcui80@hotmail.com [Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215007 (China); School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030 (China); Fan, Cunyi, E-mail: fancunyi888@hotmail.com [Department of Orthopaedics, Shanghai Sixth People' s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233 (China)

    2013-04-01

    The complications of tendon injury are frequently compromised by peritendinous adhesions and tendon sheath infection. Physical barriers for anti-adhesion may increase the incidence of postoperative infection. This study was designed to evaluate the potential of silver nanoparticles (AgNPs)-loaded poly(L-lactide) (PLLA) electrospun fibrous membranes to prevent adhesion formation and infection. Results of an in vitro drug release study showed that a burst release was followed by sustained release from electrospun fibrous membranes with a high initial silver content. Fewer fibroblasts adhered to and proliferated on the AgNP-loaded PLLA electrospun fibrous membranes compared with pure PLLA electrospun fibrous membrane. In the antibacterial test, the AgNP-loaded PLLA electrospun fibrous membranes can prevent the adhesion of Gram-positive Staphylococcus aureus and Staphylococcus epidermidis and Gram-negative Pseudomonas aeruginosa. Taken together, these results demonstrate that AgNP-loaded PLLA electrospun fibrous membranes have the convenient practical medical potential of reduction of infection and adhesion formation after tendon injury. - Highlights: ? Silver nanoparticles are directly electrospun into PLLA fibrous membrane. ? Long-lasting release of Ag + ions is achieved. ? Cytotoxicity of silver ions benefits the anti-proliferation of physical barriers. ? Broad anti-microbial effect of drug-loaded fibrous membrane is revealed. ? Antibacterial and anti-adhesion effects of the physical barriers are combined.

  14. Solitary Fibrous Tumors of the Pleura of the Thorax: CT and FDG PET Characteristics in a Tertiary Referral Center.

    Science.gov (United States)

    Yeom, Yoo Kyung; Kim, Mi Young; Lee, Hyun Joo; Kim, Sung-Soo

    2015-09-01

    This study was conducted to describe the characteristics of a solitary fibrous tumor of the pleura (SFTP) on chest CT, and FDG PET. Furthermore, we analyze the prognosis of SFTP using large data confirmed in a tertiary referral hospital. From January 1997 to March 2012, 41 patients (21 males and 20 females; median age: 59 yr; age range: 27-85 yr) who were pathologically diagnosed with SFTP were consecutively examined. The CT findings, including the size, shape, homogeneity, and anatomic location (chest wall, intrapulmonary/fissure space, diaphragm, and mediastinum) of the SFTP, the F-fluorodeoxyglucose positron emission tomography (FDG PET) findings, and the histopathology findings were evaluated. Most of the patients had a mass-type (70.7%), oval/elliptical (80.5%), and homogeneous (70.7%) SFTP with a median diameter of 6.0?cm (range: 1-17). The most common anatomic location was the chest wall (43.9%), followed by the intrapulmonary/fissure space (22.0%), diaphragm (22.0%), and mediastinum (12.3%). For all the 9 patients, the mean maxSUV was 2.9 (SD?=?1.16; range: 1.2-4.9) on FDG PET. The malignant SFTP (median: 3.6, range: 2.5-4.9) showed more hypermetabolic than benign SFTP (median: 2.0, range: 1.2-3.1) (P?=?0.049). Through familiarity with the various features of the SFTP with regard to its size and location on the preoperative CT and FDG PET, we can add this rare pleural neoplasm to the differential diagnosis of other more common conditions. Moreover, an appropriate treatment choice can be made. PMID:26402813

  15. Surgically cured hypoglycemia secondary to pleural solitary fibrous tumour: case report and update review on the Doege-Potter syndrome

    Directory of Open Access Journals (Sweden)

    Kalebi Ahmed Y

    2009-08-01

    Full Text Available Abstract The association of paraneoplastic hypoglycemia [Doege-Potter syndrome] and finger clubbing [Pierre-Marie-Bamberg syndrome] with pleural solitary fibrous tumour is rare. We present a previously unpublished but typical example of this rare occurrence together with a detailed updated literature review of previously published cases of pleural SFT discussing the histopathology of SFT; pathophysiology of the hypoglycemia and finger clubbing; treatment and outcome of pleural SFT. The patient, a 57-year-old African male was admitted at our hospital with recurrent episodes of hypoglycemia. He was found to have digital clubbing and decreased breath sounds in the right lower chest but no other significant clinical findings. His insulin level measured during an episode of hypoglycemia was undetectable. Chest radiograph and CT-scan revealed a lobulated mass in the right chest which was diagnosed to be SFT on histology. Surgical excision of the mass resulted in cure of the hypoglycemic episodes and rapid regression of the clubbing. Less than 65 cases of pleural SFT manifesting with hypoglycemia with or without finger-clubbing have been published in the English literature. The mean diameter of these tumours manifesting with hypoglycemia is 20 cm, 54% being benign while 42% were malignant. They predominantly present in the 6th-8th decade, average age of 64 years and a slight male preponderance at 58%. Complete surgical resection remains the most important predictor of clinical outcome in terms of recurrence and metastases, while providing instant cure for the hypoglycemia and rapid resolution of the finger clubbing.

  16. Cutaneous malignant lymphomas: update 2006.

    Science.gov (United States)

    Burg, G眉nter; Kempf, Werner; Cozzio, Antonio; D枚bbeling, Udo; Feit, Josef; Golling, Philippa; Michaelis, Sonja; Sch盲rer, Leo; Nestle, Frank; Dummer, Reinhard

    2006-11-01

    Cutaneous lymphomas represent a unique group of lymphomas and are the second most frequent extranodal lymphomas. As with other neoplasias, the pathogenesis is based mainly on a stepwise accumulation of mutations of suppressor genes and oncogenes caused by genetic, environmental or infectious factors. The diagnostic work-up includes clinical, histological, imaging and hematological investigations and in many cases immunohistochemical and molecular biological analyses. The current WHO/EORTC classification of cutaneous lymphomas differentiates "mature T-cell and NK-cell lymphomas", "mature B-cell lymphomas" and "immature hematopoietic malignancies", their variants and subgroups. It is compatible with the WHO classification for neoplasias of the hematopoietic and lymphoid tissue and respects the organ-specific peculiarities of primary cutaneous lymphomas. The assignment of the various types of cutaneous lymphomas into prognostic categories (pre-lymphomatous "abortive" disorders; definite malignant lymphomas of low-grade malignancy; definite malignant lymphomas of high-grade malignancy) provides essential information on the biological behavior and allows an appropriate planning of the therapeutic strategy, which may be topical or systemic and aggressive or non-aggressive. Besides the classical options for therapy, there are new and "experimental" strategies, the efficacy of which has to be studied in clinical trials. PMID:17081267

  17. Three dimensional web-like fibrous CuInS2 film

    International Nuclear Information System (INIS)

    Graphical abstract: - Highlights: 鈥 Electrospun nanofibers were used to construct a 3D CuInS2 solar cell with enhanced surface area. 鈥 SEM images showed the 3D web-like, fibrous structure of the film. 鈥 The surface area had nearly doubled after incorporating the 3D nanostructure. - Abstract: To ensure effective collection of photo-generated minority electrons in a CuInS2 thin film solar cell, a three-dimensional nanostructure was constructed by electrospinning a copper-indium solution precursor onto a molybdenum substrate. The electrospun nanofibers adhered onto the underlying layers before undergoing sulfurization at 500 掳C to produce a three-dimensional web-like fibrous CuInS2 film. This fibrous film was characterized by scanning electron microscopy, X-ray diffraction, and Auger electron spectroscopy, thereby characterizing the 3D fibrous nanostructure of the CuInS2 film. This 3D structure could lead to next-generation solar cells optimized for maximal charge separation to enhance photovoltaic efficiency of solution-processed thin film solar cells

  18. Highly-Effective Purification of Air on the Fibrous Filtering Nozzles

    Science.gov (United States)

    Galtseva, O. V.; Bordunov, S. V.; Torgaev, S. N.

    2016-02-01

    A series of experiments by air purification on fibrous filtering nozzles was made. It is experimentally shown that the fibrous filter can operate in a wide rate range. The degree of trapping of fine aerosols of glass was 99% at a linear rate of 0.01 m/s. the degree of capture decreased to 85% at the increasing of filtration rate up to 0.06 m/s. Dustiness of the air ranged from 3 to 5 g/m3 at the course of the experiment. Hydraulic resistance changed from 5 to 25 mm of water column. The calculated data of resistance and falling of pressure on fibrous filters are given; these data were received on the equations from various sources in comparison with experimentally obtained data. According to the results of series of experiments the amendment of the well-known Fuchsian equation is calculated for calculation of the resistance of fibrous air filter. This amendment considers a form and defects of surface of the fibers received by centrifugal-spinneret method.

  19. Towards high performance and multi-functional structural membranes using advanced fibrous and textile materials

    OpenAIRE

    Fangueiro, Ra煤l, ed. lit.; Rana, Sohel

    2015-01-01

    Scientific and technological advancements in the area of fibrous and textile materials have greatly enhanced their application potential in several high-end technical and industrial sectors including construction, transportation, medical, sports, aerospace engineering, electronics and so on. Excellent performance accompanied by light-weight, mechanical flexibility, tailor-ability, design flexibility, easy fabrication and relatively lower cost are the driving force...

  20. Electro spun Polyamide 4.6 Nano fibrous Nonwoven: Parameter Study and Characterization

    International Nuclear Information System (INIS)

    The aliphatic polyamide 4.6 (PA 4.6) has unique properties compared to the commonly used polyamides 6 (PA 6) and 6.6 (PA 6.6). The purpose of this paper is to produce uniform and reproducible nano fibrous PA 4.6 structures. Therefore, a mixture of the solvent formic acid and the non solvent acetic acid is used to dissolve and electro spin the PA 4.6. First the steady-state behaviour of the process and the boundary limits of the solution parameters needed for steady-state electro spinning are investigated. Subsequently, the effect of several solution and process parameters on the fibre morphology is examined, using microscopic techniques and thermal analysis. The polyamide concentration is found to be the dominant parameter affecting the fibre diameter and morphology. Furthermore, tensile tests are performed on up scaled nano fibrous structures and electro spun under optimised steady-state conditions. It is shown that the PA 4.6 nano fibrous structures, compared to nano fibrous nonwoven s of PA 6 and PA 6.6, have a higher stress and strain at break.

  1. Experimental and theoretical studies on high-temperature thermal properties of fibrous insulation

    International Nuclear Information System (INIS)

    In the present paper, an experimental apparatus has been developed to measure heat transfer through high-alumina fibrous insulation for thermal protection system. Effective thermal conductivities of the fibrous insulation were measured over a wide range of temperature (300-973 K) and pressure (10-2-105 Pa) using the developed apparatus. The specific heat and the transmittance spectra in the wavelength range of 2.5-25 渭m were also measured. The spectral extinction coefficients and Rosseland mean extinction coefficients were obtained from transmittance data at various temperatures to investigate the radiative heat transfer in fibrous insulation. A one-dimensional finite volume numerical model combined radiation and conduction heat transfer was developed to predict the behavior of the effective thermal conductivity of the fibrous insulation at various temperatures and pressures. The two-flux approximation was used to model the radiation heat transfer through the insulation. The experimentally measured specific heat and Rosseland mean extinction coefficients were used in the numerical heat transfer model to calculate the effective thermal conductivity. The average deviation between the numerical results for different values of albedo of scattering and the experimental results was investigated. The numerical results for 蠅=1 and experimental data were compared. It was found that the calculated values corresponded with the experimental values within an average of 13.5 percent. Numerical results were consistent with experimental results through the environmental conditions under examination

  2. The internal microstructure and fibrous mineralogy of fly ash from coal-burning power stations

    International Nuclear Information System (INIS)

    Coal fly ash (CFA) is a significant environmental pollutant that presents a respiratory hazard when airborne. Although previous studies have identified the mineral components of CFA, there is a paucity of information on the structural habits of these minerals. Samples from UK, Polish and Chinese power stations were studied to further our understanding of the factors that affect CFA geochemistry and mineralogy. ICP-MS, FE-SEM/EDX, XRD, and laser diffraction were used to study physicochemical characteristics. Analysis revealed important differences in the elemental compositions and particle size distributions of samples between sites. Microscopy of HF acid-etched CFA revealed the mullite present possesses a fibrous habit; fibres ranged in length between 1 and 10 ?m. Respirable particles (<10 ?m) were frequently observed to contain fibrous mullite. We propose that the biopersistence of these refractory fibres in the lung environment could be contributing towards chronic lung diseases seen in communities and individuals continually exposed to high levels of CFA. - Highlights: ? Chinese CFA had a greater crystalline mineral content and smaller particle size. ? Mullite and quartz, two hazardous minerals, recrystallise from glass melt particles. ? Mullite revealed a fibrous habit, with fibres 1-10 ?m in length and 0.5-1 ?m in width. - Chinese CFA possessed a greater crystalline mineral content and smaller particle size than UK and Polish CFA, the fibrous mullite prhiesent displayed a high aspect-ratio and thus is likely to be a respiratory hazard in vivo.

  3. The internal microstructure and fibrous mineralogy of fly ash from coal-burning power stations

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Patrick, E-mail: brownpd@cf.ac.uk [School of Earth and Ocean Sciences, Cardiff University, Park Place, CF10 3YE Cardiff (United Kingdom); School of Biosciences, Cardiff University, Museum Avenue, CF10 3US Cardiff (United Kingdom); Jones, Tim, E-mail: jonestp@cf.ac.uk [School of Earth and Ocean Sciences, Cardiff University, Park Place, CF10 3YE Cardiff (United Kingdom); BeruBe, Kelly, E-mail: berube@cf.ac.uk [School of Biosciences, Cardiff University, Museum Avenue, CF10 3US Cardiff (United Kingdom)

    2011-12-15

    Coal fly ash (CFA) is a significant environmental pollutant that presents a respiratory hazard when airborne. Although previous studies have identified the mineral components of CFA, there is a paucity of information on the structural habits of these minerals. Samples from UK, Polish and Chinese power stations were studied to further our understanding of the factors that affect CFA geochemistry and mineralogy. ICP-MS, FE-SEM/EDX, XRD, and laser diffraction were used to study physicochemical characteristics. Analysis revealed important differences in the elemental compositions and particle size distributions of samples between sites. Microscopy of HF acid-etched CFA revealed the mullite present possesses a fibrous habit; fibres ranged in length between 1 and 10 {mu}m. Respirable particles (<10 {mu}m) were frequently observed to contain fibrous mullite. We propose that the biopersistence of these refractory fibres in the lung environment could be contributing towards chronic lung diseases seen in communities and individuals continually exposed to high levels of CFA. - Highlights: > Chinese CFA had a greater crystalline mineral content and smaller particle size. > Mullite and quartz, two hazardous minerals, recrystallise from glass melt particles. > Mullite revealed a fibrous habit, with fibres 1-10 {mu}m in length and 0.5-1 {mu}m in width. - Chinese CFA possessed a greater crystalline mineral content and smaller particle size than UK and Polish CFA, the fibrous mullite prhiesent displayed a high aspect-ratio and thus is likely to be a respiratory hazard in vivo.

  4. Sorption isolation and separation of platinum metals on complexing fibrous materials

    International Nuclear Information System (INIS)

    Methods of concentration and separation of platinum metals with an application of complexing sorbents with a fibrous structure are considered in the paper of a review character. Emphasis is paid to the establishment of the character of coordination compounds in a sorbent phase

  5. Three dimensional web-like fibrous CuInS{sub 2} film

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Hyun [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of); Kim, Min-woo [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of); Green School, Korea University, Seoul, 136-713 (Korea, Republic of); Kim, Hayong [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of); Al-Deyab, Salem S. [Petrochemicals Research Chair, Dept. of Chem., King Saud University, Riyadh 11451 (Saudi Arabia); James, Scott C. [Depts of Geology and Mechanical Engineering, Baylor University, Waco TX 76798-2534 (United States); Ahn, SeJin, E-mail: swisstel@kier.re.kr [Photovoltaic Laboratory, Korea Institute of Energy Research, 71-2 Jangdong, YuseongGu, DaeJeon 305-543 (Korea, Republic of); Yoon, Sam S., E-mail: skyoon@korea.ac.kr [School of Mechanical Engineering, Korea University, Seoul 136-713 (Korea, Republic of)

    2015-10-01

    Graphical abstract: - Highlights: 鈥 Electrospun nanofibers were used to construct a 3D CuInS{sub 2} solar cell with enhanced surface area. 鈥 SEM images showed the 3D web-like, fibrous structure of the film. 鈥 The surface area had nearly doubled after incorporating the 3D nanostructure. - Abstract: To ensure effective collection of photo-generated minority electrons in a CuInS{sub 2} thin film solar cell, a three-dimensional nanostructure was constructed by electrospinning a copper-indium solution precursor onto a molybdenum substrate. The electrospun nanofibers adhered onto the underlying layers before undergoing sulfurization at 500 掳C to produce a three-dimensional web-like fibrous CuInS{sub 2} film. This fibrous film was characterized by scanning electron microscopy, X-ray diffraction, and Auger electron spectroscopy, thereby characterizing the 3D fibrous nanostructure of the CuInS{sub 2} film. This 3D structure could lead to next-generation solar cells optimized for maximal charge separation to enhance photovoltaic efficiency of solution-processed thin film solar cells.

  6. Non-contact ultrasonic technique for rapid and advanced analysis of fibrous materials

    Science.gov (United States)

    Periyaswamy, T.; Lerch, T. P.; Balasubramanian, K.

    2012-05-01

    Fibrous ensembles are, typically, multi-scale flexible assemblies with unique physical and rheological properties, unlike continuum materials. Macroscopic behaviors of these materials are greatly the result of non-linear interactions at the micro levels. These micro-scale interactions can be assessed by capturing the material behavior under low mechanical stress conditions. While ultrasonic based non-destructive testing was suitably implemented for continuum materials, their application to fibrous structures was limited primarily due to the inherent structural arrangements of these unique assemblies. Discontinuities, non-uniform orientations and multi-phase components make these ensembles difficult to study using the existing scan-based methods. This work presents a novel rapid and advanced analysis tool for complex fibrous systems using a noncontact air-coupled ultrasonic system. Five characteristic features of ultrasound signals transmitted through fibrous structures were studied, i.e., dampness in signal flight, signal velocity, power spectral density, signal power and rate of amplitude attenuation. Analysis of these features under two different acoustic frequencies, 500 kHz and 1 MHz, allowed us to study the componentized behavior of these materials for three of the key mechanical properties including bending rigidity, shear rigidity and low stress tensile stress. A material response index (MRI) was also derived using the signal features.

  7. Elastic interaction of partially debonded circular inclusions. II. Application to fibrous composite

    DEFF Research Database (Denmark)

    Kushch, V.I.; Shmegera, S.V.; Mishnaevsky, Leon

    A complete analytical solution has been obtained of the elasticity problem for a plane containing periodically distributed, partially debonded circular inclusions, regarded as the representative unit cell model of fibrous composite with interface damage. The displacement solution is written in te...... debonding phenomenon including the interface cracks cluster formation, overall stiffness reduction and damage-induced anisotropy of the effective elastic moduli of composite....

  8. Radiation Engineering in the Polymerization of Monomers in Fibrous Materials: Radioisotopes

    International Nuclear Information System (INIS)

    The choice of radiation source and plant design for polymerizing monomers in fibrous materials has been studied. A comparison is made with medical product sterilization to provide useful insight and perspective. Alternative features of irradiation plant design are considered and some general conclusions drawn. (author)

  9. Dissolving behavior and calcium release from fibrous wollastonite in acetic acid solution

    International Nuclear Information System (INIS)

    The degradability of fibrous wollastonite (CaSiO3) in an aqueous solution of acetic acid and leaching of Ca2+ ions were investigated in the temperature range from 22 to 50 oC. The Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-OES) was used for the assessment of calcium and other selected cations in the leaching medium. The amount of calcium in the solvent can be significantly enhanced through leaching at higher temperature. Fibrous silica particles are the main by-product of the leaching process. The properties of by-product were examined by thermal analysis (simultaneous TG-DTA-EGA), infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The formation of silica layer on the surface of fibrous wollastonite particles is an important factor in the leaching process. Particles were covered by the silica layer and wollastonite core size was continually decreasing during leaching. The shape of resulting silica particles shows no significant changes during this process. Specific surface of the formed fibrous silica particles strongly depends on the leaching temperature.

  10. Flexural Behaviour of Reinforced Fibrous Concrete Beams: Experiments and Analytical Modelling

    International Nuclear Information System (INIS)

    Flexural behaviour of reinforced fibrous concrete beams was investigated in this research study. Two types of metallic fibers were studied: amorphous metallic fibers (FibraFlex fibers), and carbon steel hooked-end fibers (Dramix fibers). Four types of reinforced concretes were made: one control (without fibers) and three fibrous. Among three reinforced fibrous concretes, two contained fibers in mono form and one contained fibers in hybrid form. The total quantity of fibers in mono and hybrid forms was 20 kg/m3 and 40 kg/m3, respectively. Three point bending tests were performed according to European standards NF EN 14651 on beams of 150 x 150 mm cross section and length of 550 mm. The results showed that due to positive synergetic interaction between the two metallic fibers used, reinforced fibrous concret (RFC) beams containing fibers in hybrid form exhibited better response at all loading stages. Analytical model to predict ultimate moment capacity of the RFC beam of rectangular section was developed and is presented in this paper. Analytical results for ultimate moment were found to be in good agreement with experimental results. (author)

  11. Acoustic and Visul Study of Bubble Formation Processes in Bubble Columns Staged with Fibrous Catalytic Layers

    Czech Academy of Sciences Publication Activity Database

    H枚ller, V.; R暖啪i膷ka, Marek; Draho拧, Ji艡铆; Kiwi-Minsker, L.; Renken, A.

    79-80, - (2003), s. 151-157. ISSN 0920-5861 Institutional research plan: CEZ:AV0Z4072921 Keywords : bubble formation * fibrous catalytic layers * staged bubble column Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 2.627, year: 2003

  12. Effects of Milling on the Fibrous Structure and Mechanical Behaviors of a Collagen Material--Leather

    Science.gov (United States)

    Leather, a fibrous collagen material, is a high value coproduct of the meat industry. Milling is being practiced in the tannery to mechanically tumble and therefore soften leather for adequate stiffness and feel. However, there is no report regarding its effects on the structure change and physica...

  13. Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics.

    Science.gov (United States)

    Schaefer, Inga-Marie; Fletcher, Christopher Dm; Hornick, Jason L

    2016-01-01

    The diagnosis of malignant peripheral nerve sheath tumor is challenging, particularly in the sporadic setting. Inactivation of the polycomb repressive complex 2 (PRC2), resulting from inactivating mutations of its constituents SUZ12 or EED1, has recently been identified in 70-90% of malignant peripheral nerve sheath tumors. Homozygous PRC2 inactivation results in loss of histone H3K27 trimethylation (H3K27me3). PRC2 inactivation promotes tumor progression and may render patients sensitive to epigenetic-based targeted therapies. H3K27me3 loss has not yet been validated as a diagnostic marker. We evaluated immunohistochemistry for H3K27me3 in 100 malignant peripheral nerve sheath tumors (70 sporadic, 10 neurofibromatosis type 1-associated, 10 radiation-associated, 10 epithelioid) and 200 other spindle cell neoplasms representing potential mimics (20 each monophasic synovial sarcoma, leiomyosarcoma, dedifferentiated liposarcoma, malignant solitary fibrous tumor, low-grade fibromyxoid sarcoma, cellular schwannoma, spindle cell melanoma, unclassified postradiation sarcoma; 10 each atypical neurofibroma, spindle cell rhabdomyosarcoma, gastrointestinal stromal tumor, fibrosarcomatous dermatofibrosarcoma protuberans). In total, 51 (51%) malignant peripheral nerve sheath tumors, including 34 (49%) sporadic, 7 (70%) neurofibromatosis type 1-associated, and 10 (100%) radiation-associated, but no epithelioid malignant peripheral nerve sheath tumors, were negative for H3K27me3. An additional 6 (6%) tumors showed heterogeneous H3K27me3 expression. Among the 90 sporadic, neurofibromatosis type 1-associated, and radiation-associated malignant peripheral nerve sheath tumors, complete H3K27me3 loss was observed in 29% of low-grade, 59% of intermediate-grade, and 83% of high-grade tumors (low vs intermediate/high grade, P=0.0003). Among other tumor types, 4 (20%) unclassified postradiation sarcomas were negative for H3K27me3, whereas all other neoplasms were positive. Loss of H3K27me3 is highly specific for malignant peripheral nerve sheath tumor (although only modestly more sensitive than S-100 protein and SOX10) and may be a useful diagnostic marker. Our findings suggest that PRC2 inactivation in malignant peripheral nerve sheath tumor may occur during progression to higher grades. PMID:26585554

  14. 46 CFR 160.035-8 - Construction of fibrous glass reinforced plastic (F.R.P.), oar-, hand-, and motor-propelled...

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Construction of fibrous glass reinforced plastic (F.R.P... APPROVAL LIFESAVING EQUIPMENT Lifeboats for Merchant Vessels 搂 160.035-8 Construction of fibrous glass... set forth in this subpart. (2) Fibrous glass reinforced plastic lifeboats may be of the...

  15. Analysis of MRI appearance of aggressive soft tissue tumor in hip joint region: compared with pathology

    International Nuclear Information System (INIS)

    Objective: To analyze the MRI appearance of soft tissue tumor in hip joint region, and compare it with pathological features. Methods: MR appearance of 19 soft tissue tumor in hip joint region were retrospectively analyzed, including 12 male and 7 female, 45.2 years averaged. All patients had taken common MR scanning and Gd-DTPA contrast scanning. Results: There was 5 aggressive fibromatosis, 5 malignant fibrous histiocytoma, 2 synovial sarcoma, 4 liposarcoma, 1 lymphoma, 1 primitive neuroectodermal tumor and 1 metastatic tumor. Of 19 cases, 13 with hemorrhage and necrosis, 14 with peripheral edema, nerve and vessel involved in 11. Aggressive fibromatosis appeared as isointensity or hypointensity on T1WI, and moderate hyperintensity on T2WI with low signal inside. Malignant tumor were mostly ill-defined. After contrast scanning, tumors enhanced apparently. Malignant fibrous histiocytoma showed isointensity and heter-hypointensity on T1WI, and heter-hypointensity on T2WI. Necrosis and hemorrhage occurred. All cases showed strong enhancement, except for the areas of necrosis. Edema around tumor can be seen in most cases. Conclusion: MRI can demonstrate the from and internal and peripheral structure of soft tissue tumor in hip joint region, and can contribute to the diagnosis before operation. (authors)

  16. Primary malignant small bowel tumor

    International Nuclear Information System (INIS)

    Small bowel tumors are rarely detected unless there is intestinal obstruction or bleeding. In the seven years 1982-1988, at Kosin Medical Center, 25 primary malignant small bowel tumors were studied radiographically with barium and / or computed tomography (CT). CT revealed gastrointestinal abnormalities in 20 patients. In ten, lesion were identified by upper G-I series, in 15 by small bowel series, and in addition, in 3 by colon enema. The most common malignant small bowel tumor was adenocarcinoma (N=15) and was next common lymphoma (N=7). On barium study, primary adenocarcinoma appeared as an irregular stricture (66.7%) and polypoid mass with intussusception was most prominent finding in lymphoma. Leiomyosarcoma appeared as an exophytic mass with excavation or ulceration. CT was found to be accurate in detecting wall thickening, complications and other associated findings. In conclusion, barium study was useful in the diagnosis of primary malignant small bowel tumor and CT was more accurate in detecting secondary findings

  17. Electrochemical characterization of electrospun nanocomposite polymer blend electrolyte fibrous membrane for lithium battery.

    Science.gov (United States)

    Padmaraj, O; Rao, B Nageswara; Venkateswarlu, M; Satyanarayana, N

    2015-04-23

    Novel hybrid (organic/inorganic) electrospun nanocomposite polymer blend electrolyte fibrous membranes with the composition poly(vinylidene difluoride-co-hexafluoropropylene) [P(VdF-co-HFP)]/poly(methyl methacrylate) [P(MMA)]/magnesium aluminate (MgAl2O4)/LiPF6 were prepared by the electrospinning technique. All of the prepared electrospun P(VdF-co-HFP), PMMA blend [90% P(VdF-co-HFP)/10% PMMA], and nanocomposite polymer blend [90% P(VdF-co-HFP)/10% PMMA/x wt % MgAl2O4 (x = 2, 4, 6, and 8)] fibrous membranes were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy. The fibrous nanocomposite separator-cum-polymer blend electrolyte membranes were obtained by soaking the nanocomposite polymer blend membranes in an electrolyte solution containing 1 M LiPF6 in ethylene carbonate (EC)/diethyl carbonate (DEC) (1:1, v/v). The newly developed fibrous nanocomposite polymer blend electrolyte [90% P(VdF-co-HFP)/10% PMMA/6 wt % MgAl2O4/LiPF6] membrane showed a low crystallinity, low average fiber diameter, high thermal stability, high electrolyte uptake, high conductivity (2.60 脳 10(-3) S cm(-1)) at room temperature, and good potential stability above 4.5 V. The best properties of the fibrous nanocomposite polymer blend electrolyte (NCPBE) membrane with a 6 wt % MgAl2O4 filler content was used for the fabrication of a Li/NCPBE/LiCoO2 CR 2032 coin cell. The electrochemical performance of the fabricated CR 2032 cell was evaluated at a current density of 0.1 C-rate. The fabricated CR 2032 cell lithium battery using the newly developed NCPBE membrane delivered an initial discharge capacity of 166 mAh g(-1) and a stable cycle performance. PMID:25867205

  18. Osteoarthritis of the hip in fibrous dysplasia of the proximal femur.

    Science.gov (United States)

    Kim, H-S; Im, S B; Han, I

    2015-07-01

    Deformity of the proximal femur in fibrous dysplasia leads to deviation of the mechanical axis of the hip, which may lead to the development of secondary osteoarthritis (OA). This study investigated the prevalence and predisposing factors for the development of OA in patients with fibrous dysplasia of the proximal femur. We reviewed the records of 209 patients from our institutional database with fibrous dysplasia of the proximal femur, investigating possible predisposing factors including patient demographics, the extent of the coxa vara deformity, the presence of peri-articular disease, and the overall burden of skeletal disease. Of the 209 patients, 24 (12%) had radiological evidence of OA in the ipsilateral hip. The prevalence was significantly higher in patients with polyostotic fibrous dysplasia compared with those with monostotic disease (p < 0.001). In a subgroup analysis of patients with polyostotic disease, the extent of deformity (quantified using the neck-shaft angle), and the presence of peri-articular disease (whether in the head of the femur or the acetabulum) were significant predictors of osteoarthritis (neck-shaft angle likelihood ratio (LR) = 0.847 per 1掳 increase, p = 0.004; presence of lesion in the head of the femur LR = 9.947, p = 0.027; presence of lesion in the acetabulum LR = 11.231, p = 0.014). Our data suggest that patients with polyostotic fibrous dysplasia have a high risk of developing secondary OA of the hips. This risk is higher in patients with peri-articular disease, and those with a more severe deformity of proximal femur. PMID:26130361

  19. Combined Heat Transfer in High-Porosity High-Temperature Fibrous Insulations: Theory and Experimental Validation

    Science.gov (United States)

    Daryabeigi, Kamran; Cunnington, George R.; Miller, Steve D.; Knutson, Jeffry R.

    2010-01-01

    Combined radiation and conduction heat transfer through various high-temperature, high-porosity, unbonded (loose) fibrous insulations was modeled based on first principles. The diffusion approximation was used for modeling the radiation component of heat transfer in the optically thick insulations. The relevant parameters needed for the heat transfer model were derived from experimental data. Semi-empirical formulations were used to model the solid conduction contribution of heat transfer in fibrous insulations with the relevant parameters inferred from thermal conductivity measurements at cryogenic temperatures in a vacuum. The specific extinction coefficient for radiation heat transfer was obtained from high-temperature steady-state thermal measurements with large temperature gradients maintained across the sample thickness in a vacuum. Standard gas conduction modeling was used in the heat transfer formulation. This heat transfer modeling methodology was applied to silica, two types of alumina, and a zirconia-based fibrous insulation, and to a variation of opacified fibrous insulation (OFI). OFI is a class of insulations manufactured by embedding efficient ceramic opacifiers in various unbonded fibrous insulations to significantly attenuate the radiation component of heat transfer. The heat transfer modeling methodology was validated by comparison with more rigorous analytical solutions and with standard thermal conductivity measurements. The validated heat transfer model is applicable to various densities of these high-porosity insulations as long as the fiber properties are the same (index of refraction, size distribution, orientation, and length). Furthermore, the heat transfer data for these insulations can be obtained at any static pressure in any working gas environment without the need to perform tests in various gases at various pressures.

  20. CT triage for lung malignancy

    DEFF Research Database (Denmark)

    Kusk, Martin; Karstoft, Jens; Mussmann, Bo

    2015-01-01

    assess detection performance using only coronal multiplanar reformations (MPR) when triaging patients for lung malignancies with CT compared to images in three orthogonal planes, and to evaluate performance comparison of novice and experienced readers. Material and Methods: Retrospective study of 63...... patients with suspicion of lung cancer, scanned on 64-slice multidetector computed tomography (MDCT) with images reconstructed in three planes. Coronal images were presented to four readers, two novice and two experienced. Readers decided whether the patients were suspicious for malignant disease, and...

  1. Primary supratentorial intracerebral malignant paraganglioma

    Directory of Open Access Journals (Sweden)

    Ahmed A Al Jishi

    2015-06-01

    Full Text Available Paragangliomas are extra-adrenal neuroendocrine tumors that derive from neural crest. In general, they are benign tumors but few cases had shown a tendency to metastasize. Malignant forms have been reported previously with intracranial metastasis from duodenal origin, but primary intracranial origin represents a rare and unusual location for such tumors. Here, we report a rare case of a 48-year-old lady who presented with symptomatic right-sided insular mass with negative metastatic work up. A complete surgical resection had been done with an unexpected diagnosis of primary gangliocytic paraganglioma with malignant features.

  2. Computed tomography and malignant mesothelioma

    International Nuclear Information System (INIS)

    Computed tomography (CT) is beneficial in evaluating patients with malignant mesothelioma whether of pleural or peritoneal origin. Before the advent of CT, chest radiography with tomograms and barium-contrast examinations were the prime methods in evaluation of patients with malignant mesothelioma. Computed tomography cannot replace the standard chest x-ray as a screening device but does have a definite role in evaluation of abnormalities detected on the chest x-ray in patients with asbestos exposure. Possibly the prime importance of CTs is in defining the extent of disease and evaluation of the response of the patient to therapy

  3. Fine needle aspiration biopsy of the chest lesion

    International Nuclear Information System (INIS)

    Fine needle aspiration biopsy (NAB) was done in 114 patients who showed mass like lesions in chest, to get the cytologic diagnosis and pathogenic organism at Severance Hospital Yonsei University. The result were as follows: 1. Included 114 patients with 57 malignant tumors 31 benign lesions, 18 pleural effusions and 8 unproven cases. 2. The most of patients were guided by ultrasound to approach the lesion but 18 patients by fluoroscopy due to the absence of the acoustic windows. 3. In 57 proven cases with malignant tumor, the sensitivity of NAB was 86%, but was 93% if suspicious cases were included. False negative cases were 2 lung cancers, 1 malignant fibrous histiocytoma and 1 pulmonary metastatic lesion. 4. In 31 cases with benign lesion, there was no case of false positive but specific benign diagnosis was got in 8 (25.8%). 5. So the accuracy of NAB in differentiating benign and malignant lesion was 95.5%.

  4. Radiodermatitis

    International Nuclear Information System (INIS)

    Forty-three cases of acute and chronic radiodermatitis, which occurred in the Department of Dermatology, Miyazaki Medical College between November 1977 and April 1985 were studied. Fifteen were acute and 28 were chronic. All of the original conditions treated presenting acute radiodermatitis were malignancies. Among 28 with chronic radiodermatitis, 17 had been given radiotherapy for benign conditions and 7 cases for malignant lesions. The remaining 4 were of occupational origin. Of the 28 cases with chronic radiodermatitis, histological examination was performed on 23 cases. Chronic radiodermatitis showed the following histological findings ; mild atypia in 9 (all poikilodermatous lesions showed at least mild atypia), intra-epidermal carcinoma in 6, squamous cell carcinoma in 7 and sarcoma (malignant fibrous histiocytoma) in 1. The keratotic lesions of radiodermatitis of the hands and feet tended to malignant, as compared to lesions in other areas. (author)

  5. Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

    Science.gov (United States)

    2016-02-09

    Adult Fibrosarcoma; Alveolar Soft Part Sarcoma; Angiomatoid Fibrous Histiocytoma; Atypical Fibroxanthoma; Clear Cell Sarcoma of Soft Tissue; Epithelioid Malignant Peripheral Nerve Sheath Tumor; Epithelioid Sarcoma; Extraskeletal Myxoid Chondrosarcoma; Extraskeletal Osteosarcoma; Fibrohistiocytic Neoplasm; Glomus Tumor of the Skin; Inflammatory Myofibroblastic Tumor; Intimal Sarcoma; Leiomyosarcoma; Liposarcoma; Low Grade Fibromyxoid Sarcoma; Low Grade Myofibroblastic Sarcoma; Malignant Cutaneous Granular Cell Tumor; Malignant Peripheral Nerve Sheath Tumor; Malignant Triton Tumor; Mesenchymal Chondrosarcoma; Myxofibrosarcoma; Myxoid Chondrosarcoma; Myxoinflammatory Fibroblastic Sarcoma; Nerve Sheath Neoplasm; PEComa; Pericytic Neoplasm; Plexiform Fibrohistiocytic Tumor; Sclerosing Epithelioid Fibrosarcoma; Stage IB Soft Tissue Sarcoma; Stage IIB Soft Tissue Sarcoma; Stage III Soft Tissue Sarcoma; Stage IV Soft Tissue Sarcoma; Synovial Sarcoma; Undifferentiated (Embryonal) Sarcoma; Undifferentiated High Grade Pleomorphic Sarcoma of Bone

  6. Malignant nodular hidradenoma of scalp

    Directory of Open Access Journals (Sweden)

    Tanmoy Maiti

    2014-01-01

    Full Text Available Malignant nodular hidradenoma (MNH is a rare tumor of sweat gland known by many names in the literature. Scalp is a known and yet uncommon site of occurrence. We describe two patients with scalp MNH with brain parenchymal invasion. Both tumors recurred in spite of total excision and radiotherapy.

  7. MALIGNANCY IN LARGE COLORECTAL LESIONS

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Oliveira dos SANTOS

    2014-09-01

    Full Text Available Context The size of colorectal lesions, besides a risk factor for malignancy, is a predictor for deeper invasion Objectives To evaluate the malignancy of colorectal lesions 鈮20 mm. Methods Between 2007 and 2011, 76 neoplasms 鈮20 mm in 70 patients were analyzed Results The mean age of the patients was 67.4 years, and 41 were women. Mean lesion size was 24.7 mm 卤 6.2 mm (range: 20 to 50 mm. Half of the neoplasms were polypoid and the other half were non-polypoid. Forty-two (55.3% lesions were located in the left colon, and 34 in the right colon. There was a high prevalence of III L (39.5% and IV (53.9% pit patterns. There were 72 adenomas and 4 adenocarcinomas. Malignancy was observed in 5.3% of the lesions. Thirty-three lesions presented advanced histology (adenomas with high-grade dysplasia or early adenocarcinoma, with no difference in morphology and site. Only one lesion (1.3% invaded the submucosa. Lesions larger than 30 mm had advanced histology (P = 0.001. The primary treatment was endoscopic resection, and invasive carcinoma was referred to surgery. Recurrence rate was 10.6%. Conclusions Large colorectal neoplasms showed a low rate of malignancy. Endoscopic treatment is an effective therapy for these lesions.

  8. Cutaneous manifestations of internal malignancy

    Directory of Open Access Journals (Sweden)

    A Ayyamperumal

    2012-01-01

    Full Text Available Background: Many malignancies affecting the internal organs display cutaneous manifestations which may be either specific (tumor metastases or nonspecific lesions. Aims: The study is aimed at determining the frequency and significance of cutaneous manifestations among patients with internal malignancy. Materials and Methods: 750 cases of proven internal malignancy, who attended a cancer chemotherapy center in South India, were studied. Specific infiltrates were confirmed by histopathology, fine needle aspiration cytology (FNAC and marker studies. Results: Out of the 750 patients with internal malignancy, skin changes were seen in a total of 52 (6.93% patients. Conclusion: Cutaneous metastases (specific lesions were seen in 20 patients (2.66%: contiguous in 6 (0.8%, and non-contiguous in 14 (1.86%. Nonspecific skin changes were seen in 32 patients (4.26%. None of our patients presented with more than one type of skin lesions. Herpes zoster was the most common nonspecific lesion noticed in our patients, followed by generalized pruritus, multiple eruptive seborrheic keratoses, bullous disorder, erythroderma, flushing, purpura, pyoderma gangrenosum, insect bite allergy and lichenoid dermatitis.

  9. Malignant rhabdoid tumor of liver

    OpenAIRE

    Agarwala, Sandeep; Jindal, Bibekanand; Jana, Manisha; Bhatnagar, Veereshwar; Gupta, Arun Kumar; Iyer, Venkateshwar K.

    2014-01-01

    Malignant rhabdoid tumor (MRT) is a rare, but aggressive tumor commonly arising from the kidney in young children. Extrarenal MRT has been reported in the literature in various other sites including the liver, pelvis, CNS, abdomen, heart and other soft-tissues. Reported herein are the presentation, radiology, histopathology, immunohistochemistry, treatment and outcome of a 6 month infant with primary MRT of liver.

  10. Malignant pleural effusions. Bibliographic revision

    International Nuclear Information System (INIS)

    Malignant pleural effusions are a common clinical problem in patients with neoplastic disease. Dyspnea is the most common symptom. The diagnostic is made with X ray and pleural echography. The treatment are thoracentesis, chest tube drainage and pleurodesis. Palliative therapy should be considered, necessitating evaluation of the patient's symptoms, general health and functional status, and expected survival. (The author)

  11. The Origin of Malignant Malaria

    Science.gov (United States)

    Plasmodium falciparum is the causative agent of malignant malaria, which is among the most severe human infectious diseases. Despite its overwhelming significance to human health, the parasite鈥檚 origins remain unclear. The favored origin hypothesis holds that P. falciparum and its closest known rel...

  12. X-ray diffraction study of the mineralogy of microinclusions in fibrous diamond

    Science.gov (United States)

    Smith, Evan; Kopylova, Maya; Dubrovinksy, Leonid

    2010-05-01

    Fibrous diamond, occurring both as cuboids and as coatings over non-fibrous diamond nuclei, is translucent due to the presence of millions of sub-micron-sized mineral and fluid inclusions. Diamond is strong and relatively inert, making it an excellent vessel to preserve trapped materials. These microinclusions represent direct samples of natural diamond-forming mantle fluids, and are critical for our understanding of diamond genesis. Traditionally, infrared spectroscopy, Raman spectroscopy, secondary ion mass spectrometry, electron microprobe, and FIB-TEM techniques have proven to be effective for the study of microinclusions in diamond. The abundance and random orientation of included minerals in fibrous diamond make them amenable to a powder-type X-ray diffraction (XRD) technique. This technique provides an accurate way to identify included minerals. It also has the advantage of analyzing thousands of inclusions simultaneously, rather than analyzing one inclusion at a time, as with common FIB-TEM techniques. XRD provides a bulk analysis, giving a superior measure of relative abundances of included minerals, as well as potentially accounting for small quantities of minerals that might otherwise be overlooked. We studied fibrous cuboid diamonds with microinclusions from the Democratic Republic of Congo (DRC) (23 samples), Brazil (4 samples), Jericho (1 sample), and Wawa conglomerates (9 samples). XRD analysis was performed at the Bayerisches Geoinstitut (BGI), University of Bayreuth, Germany. The unique XRD setup consists of a RIGAKU FR-D high-brilliance source, OSMIC Inc. Confocal Max-Flux optics, and a SMART APEX 4K CCD area detector. Preliminary XRD studies of microinclusions 8 fibrous diamonds from the DRC showed a prevalence of silicates with structural and coordinated H2O. Sheet silicates constituted 9 out of 13 detected minerals, with phlogopite-biotite micas being present in 4 out of 8 samples. Other detected minerals were 2 chlorite minerals, 2 clay phyllosilicates, serpentine, zircon, a hydrous carbonate and an unidentified zeolite. Many of these phases are deuteric, replacing high-T, high-P micas and carbonates that precipitate from the fluid in the diamond stability field. The ongoing XRD study will (1) elucidate the mineralogy of fluid inclusions in diamonds from Wawa, (2) compare XRD analyses to distinguish between diamonds with carbonatitic versus saline fluid compositions, and (3) reveal whether carbonates occur as crystalline phases or as dissolved or amorphous material in fibrous diamond.

  13. New MRI techniques for staging malignant lymphoma

    OpenAIRE

    T. C. Kwee

    2011-01-01

    Malignant lymphomas are a heterogenous group of malignancies, belonging to the ten most frequent types of cancers worldwide. Once a malignant lymphoma has been diagnosed, it is important to assess disease extent (staging), because this has prognostic and therapeutic implications. Computed tomography (CT) and 18F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET)/CT are commonly used imaging methods for the staging of malignant lymphoma. An important disadvantage of CT and FDG-PET/CT...

  14. Malignant pulmonary tumors in children; Maligne Lungentumoren im Kindesalter

    Energy Technology Data Exchange (ETDEWEB)

    Balassy, C.; Kulemann, V.; Hoermann, M. [Allgemeines Krankenhaus Wien, Abteilung fuer Allgemeine Radiologie und Kinderradiologie, Wien (Austria)

    2008-10-15

    Pulmonary neoplasms in children are rare. The majority of tumors involving the respiratory system are metastatic and primary lung tumors are even more rare. Approximately 75% of primary lung tumors are malignant, the most frequent of which are adenoma, bronchogenic carcinoma, and pleuropulmonary blastoma. Due to the rarity of these malignancies, and the usually nonspecific clinical symptoms, they are often not considered in the differential diagnosis in children who present with persistent pneumonitis, coughing, and atelectasis. This often results in delayed definitive treatment and, in general, a worse prognosis. The role of the radiologist is that by using modern imaging techniques, to facilitate early recognition and staging, enabling adequate treatment and follow-up and thus, a better clinical prognosis. This article provides an overview of the most relevant entities of primary childhood pulmonary malignancies, with a particular emphasis on the imaging characteristics. (orig.) [German] Lungentumoren im Kindesalter sind selten; hauptsaechlich handelt es sich dabei um sekundaere Absiedelungen anderer Tumoren. Wesentlich seltener finden sich Primaertumoren der Lunge. Etwa 75% dieser Tumoren sind maligne; zu den haeufigsten Entitaeten zaehlen das Adenom, das Bronchuskarzinom und das pleuropulmonale Blastom. Auf Grund des seltenen Auftretens und der unspezifischen klinischen Symptomatik, mit denen sich die betroffenen Kinder praesentieren, werden diese Tumoren kaum in die differenzialdiagnostischen Ueberlegungen miteinbezogen. Das zoegert naturgemaess die korrekte Diagnosestellung, v. a. aber den Therapiebeginn hinaus und kann somit zu einer Verschlechterung der Prognose fuehren. Die Rolle der Radiologie liegt darin, mit der Nutzung der modernsten Schnittbildtechniken eine fruehzeitige Erkennung, ein umfassendes Staging und eine adaequate Therapiekontrolle zu ermoeglichen, um die Gesamtprognose der Kinder mit Lungentumoren zu verbessern. Im Folgenden soll ein Ueberblick ueber die wichtigsten Lungentumoren im Kindesalter gegeben werden. (orig.)

  15. Renal cell carcinoma presenting with malignant ascites

    OpenAIRE

    Jennison, Erica; Wathuge, Gayathri W; Gorard, David A

    2015-01-01

    Lesson It is rare for renal cell carcinoma to involve the peritoneum and cause malignant ascites. Furthermore, it is uncommon for malignant ascites to be a presenting feature of this cancer. An unusual case of renal cell carcinoma presenting with malignant ascites is reported, and its response to sunitinib described.

  16. Diabetic fibrous breast disease: description of a case with bilateral involvement and gradual spontaneous regression

    International Nuclear Information System (INIS)

    We describe the clinica, radiologica and histopathological features of this rare bening breast disease in a 28-year-old patient with a long-standing history of insulin-dependent diabetes mellitus. The patient presented bilateral breast masses, mammography revealed dense breast and ultrasound demonstrated the presence of bilateral anechoic masses with irregular borders and posterior acoustic shadowing. Fine needle aspiration biopsy yielded and amorphous, a cellular hyaline-like material. The histological analysis of surgical biopsy specimens from both breast revealed the presence of keloid fibroblast with lymphocytic lobulitis. The clinical and histological findings suggested the diagnosis of the diabetic fibrous breast disease. Over 8 years of clinical follow-up the masses were seen to regress spontaneously. We confirm the findings reported previously in the literature. suggesting that those patients who fulfill the clinical cytological and imaging criteria for diabetic fibrous breast disease can be managed by clinical means, avoiding the need for surgical biopsy. (Author) 19 refs

  17. Mobility of Power-law and Carreau Fluids through Fibrous Media

    CERN Document Server

    Shahsavari, Setareh

    2015-01-01

    The flow of generalized Newtonian fluids with a rate-dependent viscosity through fibrous media is studied with a focus on developing relationships for evaluating the effective fluid mobility. Three different methods have been used here: i) a numerical solution of the Cauchy momentum equation with the Carreau or power-law constitutive equations for pressure-driven flow in a fiber bed consisting of a periodic array of cylindrical fibers, ii) an analytical solution for a unit cell model representing the flow characteristics of a periodic fibrous medium, and iii) a scaling analysis of characteristic bulk parameters such as the effective shear rate, the effective viscosity, geometrical parameters of the system, and the fluid rheology. Our scaling analysis yields simple expressions for evaluating the transverse mobility functions for each model, which can be used for a wide range of medium porosity and fluid rheological parameters. While the dimensionless mobility is, in general, a function of the Carreau number an...

  18. Hydraulic permeability of (un)bounded fibrous media using the lattice Boltzmann method

    International Nuclear Information System (INIS)

    Several articles have been written regarding the hydraulic permeability of ordered and disordered fibrous media. Here, we explore wall effects on hydraulic permeabilities for ordered and disordered media using the lattice Boltzmann (LB) simulation method. Simulation results are found to be in excellent agreement with the semi analytic result of Sangani and Acrivos, and simulation results for disordered media are in good agreement with the results of Jackson and James and Higdon and Ford's fcc lattice. The macroscopic behavior, the hydraulic permeability, shows a distinct connection with the geometry of the system. This connection is explored and elucidated for ordered and disordered media. Finally, hydraulic permeabilities for bounded media at various wall separations are presented for both ordered and disordered media and results are compared with hydraulic permeabilities calculated for the unbounded media, and a phenomenological correlation is presented to facilitate rapid prediction of hydraulic permeabilities for both unbounded and bounded fibrous media. (c) 2000 The American Physical Society

  19. Influence of fibrous encapsulation on electro-chemical properties of TiN electrodes.

    Science.gov (United States)

    Meijs, Suzan; Fjorback, Morten; Jensen, Carina; S酶rensen, S酶ren; Rechendorff, Kristian; Rijkhoff, Nico J M

    2016-05-01

    The aim of this study was to investigate how the electrochemical properties of porous titanium nitride stimulation electrode are affected by fibrous encapsulation in vivo. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry and voltage transient (VT) measurements were performed in vivo and in phosphate buffered saline, where the encapsulation process is absent. EIS was used as a non-invasive measurement to follow the inflammation, healing and encapsulation process. EIS showed that the healing and encapsulation process lasted 3-4 weeks. The VTs increased during the first 3-4 weeks, after which they stabilized. The charge storage capacity (CSC) decreased most during the first 3-4 weeks. The increasing VTs and decreasing CSC during the first 3-4 weeks after implantation of the in vivo electrodes seem related to healing and fibrous encapsulation. It is suggested that the charge injection pathway during the encapsulation process changes, which implies that charge injection limits are underestimated with conventional methods. PMID:26997562

  20. Theoretical study of the fibrous capsule tissue growth around a disk-shaped implant

    KAUST Repository

    Djellouli, Rabia

    2012-08-19

    We analyze the mathematical properties of the fibrous capsule tissue concentration around a disk-shaped implant. We establish stability estimates as well as monotonicity results that illustrate the sensitivity of this growth to the biocompatibility index parameters of the implant. In addition, we prove that the growth of the tissue increases exponentially in time toward an asymptotic regime. We also study the mathematical properties of the solution of the inverse problem consisting in the determination of the values of the biocompatibility index parameters from the knowledge of some fibrous capsule tissue measurements. We prove that this model calibration problem admits a unique solution, and establish a characterization of the index parameters. Furthermore, we demonstrate analytically that such a solution is not continuous with respect to the data, and therefore the considered inverse problem is ill-posed due to the lack of the stability requirement. 漏 2012 Springer-Verlag.

  1. Composition of silicon fibrous nanostructures synthesized using ultrafast laser pulses under ambient conditions

    Directory of Open Access Journals (Sweden)

    Sivakumar M.

    2015-01-01

    Full Text Available In this study the composition of nanostructures generated owing to ablation of crystalline silicon using high repletion rate femtosecond laser under ambient condition is investigated. The web-like silicon fibrous nanostructures are formed in and around the laser irradiated area. Electron Microscopy investigation revealed that the nanostructures are made of nanoparticles of size about 40 nm. In addition Micro-Raman analysis shows that the nanofibrous structures comprises a mixture of amorphous and polycrystalline silicon. X-ray photoelectron spectroscopy analysis reveals the oxidized and un-oxidized elemental states of silicon in the nanostructures. Moreover web-like fibrous nanostructures are generated due to condensation of super saturated vapour and subsequent nucleus growth in the laser induced plasma plume.

  2. Fibrous flexible solid-type dye-sensitized solar cells without transparent conducting oxide

    International Nuclear Information System (INIS)

    We have explored a type of all-solid fibrous flexible dye-sensitized solar cells without transparent conducting oxide based on a CuI electrolyte. The working electrode's substrate is a metal wire. Cu wire counterelectrode is twisted with the dye-sensitized and CuI-coated working electrode. The cell's apparent diameter is about 150 渭m. The cell's current-voltage output depends little on the incident angle of light. A 4-cm-long fibrous cell's open-circuit voltage and short-circuit current generate 304 mV and 0.032 mA, respectively. The interfacial interaction between the two electrodes has a significant influence on the inner charge transfer of the cell

  3. Hunger in pregnant sows: Effects of a fibrous diet and free access to straw

    DEFF Research Database (Denmark)

    Jensen, Margit Bak; Pedersen, Lene Juul; Theil, Peter Kappel; Knudsen, Knud Erik Bach

    2015-01-01

    Fibrous diets and the provision of straw have been suggested to reduce feeding motivation in pregnant sows. The present experiment investigated the separate and interactive effects of a fibrous diet and ad libitum access to straw on feeding motivation, oral behaviour and plasma levels of...... the period they were fed the control diet. Sows with limited access to straw manipulated equipment less frequently during the period they were fed the fibre diet, while no effect of diet was seen among sows with ad libitum straw (diet 脳 straw interaction P < 0.001). In conclusion, feeding motivation...... periods. Furthermore, the sows鈥 feeding motivation was assessed during behavioural tests, and blood samples were draw via a jugular vein catheter, at 0700, 0900, 1200 and 1900 h in a balanced design. Feeding motivation was not affected by diet or straw. However, feeding motivation was highest 1 h before...

  4. Welcome to Fibers鈥擜 New Open Access Journal for Fibrous Material Science

    Directory of Open Access Journals (Sweden)

    Stephen C. Bondy

    2012-08-01

    Full Text Available Fibers are materials in the form of elongated threads. They can possess elastic features that are relevant to the integrity and bonding of cells. These features also give man-made fibers a wide range of applications. The large ratio of length to width (aspect ratio, which defines fibers, strongly influences their physical and chemical properties. This quality gives them a relatively large surface area, which can lead to powerful tensile and absorptive characteristics, which are remarkably different from, and cannot be predicted by study of the non-fibrous parent materials. An example of this is asbestos, where the toxicity of the material is heavily influenced by its structural anatomy. Distinctive chemical processes can take place on fibrous surfaces that may themselves seem to be chemically inert. Certain commonalities result from the distinctive geometry of fibers, and lie behind the apparently great diversity of fiber types and materials. [...

  5. Imaging diagnosis of monostotic fibrous dysplasia in thoracic and lumbar spine vertebrae.

    Science.gov (United States)

    Yang, Caihong; Zhu, Bo; Chen, Anmin

    2007-12-01

    The X-ray radiograph, CT scan and MRI appearance of 5 patients with pathologically proven fibrous dysplasia in thoracic and lumbar spine vertebrae were retrospectively analyzed. Plain radiographs, CT scans and MR images showed the presentation of eccentric lesion with intact cortex bone and marginal sclerosis in vertebral bodies without involvement of vertebral appendix and extraosseous soft tissue. The lesion masses were round (one being oval-shaped) and radiolucent in plain radiographs and CT scans. Homogeneous long signal was observed on T1 weighted image and strongly enhanced when gadolinium was administered. On T2 weighted MRI, short signal was found in the anterior part of the mass, long signal in the posterior part, and short and slight long signal in the middle part, without partitioning and laminating change. There was a good correlation between radiological features and surgical findings. These findings may be useful to diagnose fibrous dysplasia in spine. PMID:18231743

  6. Aortic periannular abscess invading into the central fibrous body, mitral valve, and tricuspid valve.

    Science.gov (United States)

    Oh, Hyun Kong; Kim, Nan Yeol; Kang, Min-Woong; Kang, Shin Kwang; Yu, Jae Hyeon; Lim, Seung Pyung; Choi, Jae Sung; Na, Myung Hoon

    2014-06-01

    A 61-year-old man was diagnosed with aortic stenoinsufficiency with periannular abscess, which involved the aortic root of noncoronary sinus (NCS) that invaded down to the central fibrous body, whole membranous septum, mitral valve (MV), and tricuspid valve (TV). The open complete debridement was executed from the aortic annulus at NCS down to the central fibrous body and annulus of the MV and the TV, followed by the left ventricular outflow tract reconstruction with implantation of a mechanical aortic valve by using a leaflet of the half-folded elliptical bovine pericardial patch. Another leaflet of this patch was used for the repair of the right atrial wall with a defect and the TV. PMID:25207228

  7. Malignant peritoneal mesothelioma after cholangiography with thorotrast.

    Science.gov (United States)

    Maurer, R; Egloff, B

    1975-10-01

    Reported is a 59-year-old patient, who died of a peritoneal mesothelioma 36 years after contamination with thorotrast of the peritoneal cavity during cholangiography at cholecystectomy. Eleven years before death, the right kidney had to be removed for hydronephrosis due to fibrous stenosis of the pyeloureteral junction, because of thorium dioxide deposits. PMID:1175135

  8. Fibrous Agricultural Biomass as a Potential Source for Bioconversion to Vanillic Acid

    OpenAIRE

    Pei-Ling Tang; Osman Hassan; Jamaliah Md-Jahim; Wan Aida Wan Mustapha; Mohamad Yusof Maskat

    2014-01-01

    This study was conducted to assess the potential of six fibrous agricultural residues, namely, oil palm empty fruit bunch fiber (OPEFBF), coconut coir fiber (CCF), pineapple peel (PP), pineapple crown leaves (PCL), kenaf bast fiber (KBF), and kenaf core fiber (KCF), as a source of ferulic acid and phenolic compounds for bioconversion into vanillic acid. The raw samples were pretreated with organosolv (NaOH-glycerol) and alkaline treatment (NaOH), to produce phenol-rich black liquor. The findi...

  9. Complexation of fibrous Tiopan-1 sorbent with cadmium(2), cobalt(2) zinc(2) ions

    International Nuclear Information System (INIS)

    Complex formation processing of functional groups of fibrous sulfur-nitrogen-containing adsorbent Tiopan-1 with cadmium ions are studied using potentiometry, IR-spectroscopy, as well as electron spectroscopy with diffusion reflection. Composition of forming complexes in adsorbent phase is established. Stability constants are determined in 0.096-1.92 ionic force interval of sodium chloride phone. Thermodynamic constants of stability are calculated

  10. Self-Organized Criticality in a Model for Fracture on Fibrous Materials

    OpenAIRE

    Bernardes, A; Moreira, J.

    1995-01-01

    We investigate the existence of self-organized criticality on a model to describe the failure process in fibrous materials. This model consists of identical parallel fibers which are pulled with constant velocity. The rupture probability of each fiber depends on the elastic energy of the fiber and on the number of unbroken neighboring fibers. In the brittle-ductile transition, we have observed a power law behaviour on the number of cracks versus its size. This indicates that, in this region, ...

  11. Chemical method of fibrous materials surface activation on the basis of polyethylene terephthalate (PET)

    OpenAIRE

    Prorokova, Natalia; Chorev, Alexey; Kuzmin, Sergey; Vavilova, Svetlana; Prorokov, Valeriy

    2014-01-01

    The possibility of surface activation of polyethylene terephthalate materials due to their weak alkaline hydrolysis which does not cause weakening of the fibrous material has been shown. The activation has the positive effect on the functional products application on polyester material surface. It has been shown that during weak surface hydrolysis the initially smooth surface of PET becomes rough (at nanoscale level) that increases adhesion of functional products for polyester material. 袩芯...

  12. Mechanical energy transfer and dissipation in fibrous beta-sheet-rich proteins

    OpenAIRE

    Xu, Zhiping; Buehler, Markus J.

    2010-01-01

    Mechanical properties of structural protein materials are crucial for our understanding of biological processes and disease states. Through utilization of molecular simulation based on stress wave tracking, we investigate mechanical energy transfer processes in fibrous beta-sheet-rich proteins that consist of highly ordered hydrogen bond (H-bond) networks. By investigating four model proteins including two morphologies of amyloids, beta solenoids, and silk beta-sheet nanocrystals, we find tha...

  13. Mulitmodality management of rare solitary fibrous tumor can be associated with extended survival

    OpenAIRE

    Thomas Mindermann; Robert Reisch

    2014-01-01

    Background: Little is known on the long-term course of patients treated for intracranial solitary fibrous tumors (iSFT). We therefore retrospectively reviewed the charts of our patients who underwent Gamma Knife radiosurgery (GKRS) for iSFT at Klinik Im Park in Zurich and who were treated by one of the authors. Between 1994 and 2009, two patients underwent GKRS for iSFT at Klinik Im Park. Case Description: One patient underwent altogether five radiosurgical treatments and two craniotomies...

  14. Investigations into resistance to thermal oxidation of carbon fibrous thermal insulating materials

    International Nuclear Information System (INIS)

    A study on thermal oxidation stability of carbon fibrous thermal insulation materials differing by manufacture technology, the content of heat resistant additions and texture was made. Investigations were conducted in air in 500-800 deg C range. It was revealed that materials subjected to heat treatment at higher temperature were characterized by the highest thermal oxidation stability. Results of testing structural fragment of thermal insulation under conditions simulating accidental mode of VG-400 and VGM plants, are presented. 2 figs

  15. Non-standard test methods for long-fibrous reinforced composite materials

    OpenAIRE

    L.A. Dobrza艅ski; A.J. Nowak; W. B艂a偶ejewski; R. Rybczy艅ski

    2011-01-01

    Purpose: The investigations serve as comparative verification of silicone-aramid material designed for oesophageal prosthesis.Design/methodology/approach: In this work, non-standard research techniques, particularly designated for comparative tests of long-fibrous composite materials, are presented. Those tests are carried out on equipment similar to so called NOL rings test and pressure tests using rubber as a working mediumFindings: During interpretation of pressure tests results according ...

  16. 飦 Radio frequency removed of hypertrophied anal papillae and fibrous anal polyps

    OpenAIRE

    Pravin J. Gupta

    2013-01-01

    Objective: The presence of hypertrophied anal papillaeand fibrous anal polyps is mostly ignored while dealingwith chronic anal fissures. However, anal papilla tendsto produce a discharge resulting in a sodden perianalskin with itching and discomfort. Similarly, polyps canprolapse, bleed or traumatize. This study is aimed toassay the impact and utility of attending to these twoconditions concurrently while dealing with cases offissure in ano.Method: A prospective study was carried out in 100pa...

  17. Current approach to fibrous dysplasia of bone and McCune鈥揂lbright syndrome

    OpenAIRE

    Leet, Arabella I.; Collins, Michael T.

    2007-01-01

    Fibrous dysplasia (FD) of bone is an uncommon disease caused by sporadic, congenital mutations in the cAMP regulating protein, Gs伪. It is an example of somatic mosaicism in which a wide spectrum of disease is possible. Widespread skeletal involvement is often associated with varying combinations of caf茅-au-lait skin spots, and/or endocrine dysfunction (precocious puberty, renal phosphate wasting, hyperthyroidism, and/or growth hormone excess). Unrecognized and untreated endocrine dysfunction ...

  18. Structured fibrous carbon-based catalysts for continuous nitrate removal from natural water

    OpenAIRE

    Yuranova, T.; Franch, C.; Palomares, A. E.; Garcia-Bordej茅, E.; Kiwi-Minsker, L.

    2012-01-01

    Bimetallic (Pd-Cu, Pd-Sn) nanoparticles supported on structured fibrous carbons (activated carbon fibers and carbon nanofibers grown on sintered metal fibers) were tested in nitrate removal of natural polluted water by hydrogen (a batch and continuous mode). Dependence of the activity/selectivity on catalyst chemical composition, promoter nature and metal particle size was studied. Sn-modified Pd nanoparticles showed higher N 2 selectivity as compared to Cu-modified ones. The structured (Pd-S...

  19. Structure and properties of permeable fine-fibrous materials fabricated of powders

    International Nuclear Information System (INIS)

    Effect of main structural characteristicf of fine fibrous materials (FFM) of nickel and Ni-Cr, Ni-Mo, Ni-Cr-Mo, Ni-Fe-Cr, Ni-Fe alloys on their hydraulic and mechanical properties was studied. FFM was produced by sintering of polymer fibers filled with metal powders and converted to felts. It was shown, that the level of permeable material properties increases with reduction of filament diameter

  20. Fibrous active carbon based adsorbents for the purification of liquid media polluted by radionuclides

    International Nuclear Information System (INIS)

    There has been considered the influence of surface state and pore structure, as well as type of impregnating additives and conditions of their introduction, on the properties of modified carbon fibrous sorbents for purification of liquid media concurrently from radionuclides and harmful organic impurities. With the aid of a model system there has been shown high efficiency of modified sorbent containing iron (3) ferrocyanide in the extraction of cesium and strontium radioisotopes from biological media

  1. Morphosynthesis: high fidelity inorganic replica of the fibrous network of loofa sponge (Luffa cylindrica)

    OpenAIRE

    Italo O. Mazali; Alves, Oswaldo L.

    2005-01-01

    High fidelity calcium carbonate and hydroxyapatite (bio) inorganic replicas of the fibrous network of the dried fruit of Luffa cylindrica are described, utilizing a facile synthetic route. The loofa sponge is a highly complex macroscopic architectural template, an inexpensive and sustainable resource. In the context of the morphosynthesis, the capability of replication of the loofa sponge opens the possibility of the use of biodiversity in obtaining new materials. We would like to emphasize t...

  2. Gene expression profiling of craniofacial fibrous dysplasia reveals ADAMTS2 overexpression as a potential marker

    OpenAIRE

    Zhou, Shang-Hui; Yang, Wen-Jun; Liu, Sheng-Wen; LI, JIANG; ZHANG, CHUN-YE; Zhu, Yun; Zhang, Chen-Ping

    2014-01-01

    Fibrous dysplasia (FD) as an abnormal bone growth is one of the common fibro-osseous leasions (FOL) in oral and maxillofacial region, however, its etiology still remains unclear. Here, we performed gene expression profiling of FD using microarray analysis to explore the key molecule events in FD development, and develop potential diagnostic markers or therapeutic targets for FD. We found that 1,881 genes exhibited differential expression with more than two-fold changes in FD compared to norma...

  3. Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells

    OpenAIRE

    Riminucci, Mara; Robey, Pamela Gehron; Saggio, Isabella; Bianco, Paolo

    2010-01-01

    Activating mutations of the GNAS gene, which causes fibrous dysplasia of bone (FD), lead to remarkable changes in the properties of skeletal progenitors, and it is these changes that mediate the pathological effect of this gene on bone. Mutated skeletal stem cells lose the ability to differentiate into adipocytes, and to maintain in situ, and transfer heterotopically, the hematopoietic microenvironment, leading to abnormal bone marrow histology in FD. They over-express molecular effectors of ...

  4. Solitary fibrous tumour of the pleura: an ultrastructural and immunohistochemical study.

    OpenAIRE

    Keating, S.; Simon, G. T.; Alexopoulou, I; Kay, J. M.

    1987-01-01

    Solitary fibrous tumour of the pleura is a benign neoplasm differing from diffuse pleural mesothelioma. It was originally thought to be a variant of mesothelioma because it consists of a spindle cell stroma associated with branching tubular structures lined by cuboidal cells. In this study of two cases the tubular structures were lined with ciliated and non-ciliated cuboidal cells. Ultrastructurally most of the non-ciliated cells had the features of type II pneumocytes, while the stromal cell...

  5. Hierarchical starch-based fibrous scaffold for bone tissue engineering applications

    OpenAIRE

    Martins, A.; Chung, S.(Pusan National University, Pusan, South Korea); Pedro, A. J.; Sousa, R. A.; Marques, A. P.; Reis, R.L; Neves, N. M.

    2009-01-01

    Fibrous structures mimicking the morphology of the natural extracellular matrix are considered promising scaffolds for tissue engineering. This work aims to develop a novel hierarchical starch-based scaffold. Such scaffolds were obtained by a combination of starch-polycaprolactone micro- and polycaprolactone nano-motifs, respectively produced by rapid prototyping (RP) and electrospinning techniques. Scanning electron microscopy (SEM) and micro-computed tomography analysis showed the successfu...

  6. Vulvar malignancy in neurofibromatosis syndrome.

    Science.gov (United States)

    Musella, Angela; Palaia, Innocenza; Domenici, Lavinia; Casorelli, Assunta; Martoccia, Angela; Benedetti Panici, Pierluigi

    2013-01-01

    Type 1 neurofibromatosis (NF1) is a dominantly inherited neurologic disorder that affects primarily the skin, bones, and peripheral nervous system. It may be associated with a variety of clinical manifestations including cafe-au-lait spots, skinfold freckling, Lisch nodules, and visceral neurofibromas. Individuals affected by NF1 harbor an increased risk for both benign and malignant tumors. Malignant transformation is usually observed in the form of neurosarcoma. Rarely, NF1 affects the genital tract, and isolated vulvar localization is extremely rare. Here is reported a rare case of a solitary neurosarcoma of the vulva in a 43-year-old woman affected by NF1 syndrome treated with surgical excision. The purpose of this case is to underline the possibility of association between NF1 and genital tract sarcoma and to suggest an accurate evaluation of rapid growth vulvar mass in this setting. PMID:24167749

  7. Paediatric and adult malignant glioma

    DEFF Research Database (Denmark)

    Jones, Chris; Perryman, Lara; Hargrave, Darren

    2012-01-01

    Gliomas in children differ from their adult counterparts by their distribution of histological grade, site of presentation and rate of malignant transformation. Although rare in the paediatric population, patients with high-grade gliomas have, for the most part, a comparably dismal clinical outcome...... to older patients with morphologically similar lesions. Molecular profiling data have begun to reveal the major genetic alterations underpinning these malignant tumours in children. Indeed, the accumulation of large datasets on adult high-grade glioma has revealed key biological differences between...... the adult and paediatric disease. Furthermore, subclassifications within the childhood age group can be made depending on age at diagnosis and tumour site. However, challenges remain on how to reconcile clinical data from adult patients to tailor novel treatment strategies specifically for paediatric...

  8. Tumor Metabolism of Malignant Gliomas

    Energy Technology Data Exchange (ETDEWEB)

    Ru, Peng; Williams, Terence M.; Chakravarti, Arnab; Guo, Deliang, E-mail: deliang.guo@osumc.edu [Department of Radiation Oncology, Ohio State University Comprehensive Cancer Center & Arthur G James Cancer Hospital, Columbus, OH 43012 (United States)

    2013-11-08

    Constitutively activated oncogenic signaling via genetic mutations such as in the EGFR/PI3K/Akt and Ras/RAF/MEK pathways has been recognized as a major driver for tumorigenesis in most cancers. Recent insights into tumor metabolism have further revealed that oncogenic signaling pathways directly promote metabolic reprogramming to upregulate biosynthesis of lipids, carbohydrates, protein, DNA and RNA, leading to enhanced growth of human tumors. Therefore, targeting cell metabolism has become a novel direction for drug development in oncology. In malignant gliomas, metabolism pathways of glucose, glutamine and lipid are significantly reprogrammed. Moreover, molecular mechanisms causing these metabolic changes are just starting to be unraveled. In this review, we will summarize recent studies revealing critical gene alterations that lead to metabolic changes in malignant gliomas, and also discuss promising therapeutic strategies via targeting the key players in metabolic regulation.

  9. Calculation software for efficiency and penetration of a fibrous filter medium based on the mathematical models of air filtration

    OpenAIRE

    Kouropoulos, Giorgos

    2014-01-01

    At this article will be created a software written in visual basic for efficiency and penetration calculation in a fibrous filter medium for given values of particles diameter that are retained in the filter. Initially, will become report of mathematical models of air filtration in fibrous filters media and then will develop the code and the graphical interface of application, that are the base for software creation in the visual basic platform.

  10. Republic of Korea [Status and technology of polymer-containing fibrous materials in the Eastern Hemisphere

    International Nuclear Information System (INIS)

    In describing the present status of composite materials made from fibrous materials and synthetic polymers, it should first be mentioned that Korea produces almost no polymer-wood combinations. However, Korea has been very active in the production of various resin-fibrous material combinations that mainly employ thermosetting resins as binding agents to improve the quality of woods and other fibrous materials. Plywood, chip board, hard board and straw board are some examples. Korean forest resources are not sufficient to meet industrial needs. Only a small amount of domestic pine timber is used for ground pulp production. However, plywood production, which started some ten years ago, has increased to where domestic consumption is now fully supplied and annual exports are now worth more than 40 million US dollars. Although whole log timber for the industry is imported, urea and formalin for adhesives are produced domestically. To develop an effective means for using waste lumber, chip board, fibre board and hard board have been produced since 1962 and the production of straw board has been started as a means of utilizing agricultural wastes

  11. Electrospinning of fibrous polymer scaffolds using positive voltage or negative voltage: a comparative study

    International Nuclear Information System (INIS)

    Electrospinning of fibrous tissue engineering scaffolds has been traditionally conducted using positive voltages. In the current study, positive voltage (PV) electrospinning and negative voltage (NV) electrospinning were investigated for forming fibrous membranes of poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV). In both PV-electrospinning and NV-electrospinning, the fiber diameter generally increased with increasing needle inner diameter and PHBV concentration but decreased with increasing working distance. The use of a conductivity-enhancing surfactant, benzyl triethylammonium chloride (BTEAC), significantly reduced PHBV fiber diameters from the micron scale to the sub-micron scale. Interestingly, with increasing applied voltage, the fiber diameter increased for PV-electrospinning but decreased for NV-electrospinning. The PV-electrospun fibrous membranes from solutions without BTEAC (PVEfm) and with BTEAC (PVEfm-B) and NV-electrospun membranes from solutions without BTEAC (NVEfm) and with BTEAC (NVEfm-B) were characterized in terms of their structure, wettability, thermal properties and tensile properties. Both PVEfm and NVEfm exhibited similar water contact angles (?1040) but the contact angle of PVEfm-B or NVEfm-B was not measurable. The elongation at break of PVEfm-B or NVEfm-B was significantly higher than that of PVEfm or NVEfm. Using NV-electrospinning or a combination of NV- and PV-electrospinning may be very useful for developing suitable scaffolds for tissue engineering applications.

  12. Cellulose nanocrystal-filled poly(acrylic acid) nanocomposite fibrous membranes

    International Nuclear Information System (INIS)

    Nanocomposite fibrous membranes have been fabricated by electrospinning cellulose nanocrystal (CNC)-loaded poly(acrylic acid) (PAA) ethanol mixtures. Incorporating CNC in PAA significantly reduced fiber diameters and improved fiber uniformity. The average diameters of the as-spun nanocomposite fibers were significantly reduced from 349 nm to 162 nm, 141 nm, 90 nm and 69 nm at 5%, 10%, 15% and 20% CNC loading (by weight of a constant 4% PAA solution), respectively. CNC was well dispersed in the fibers as isolated rods oriented along the fiber axis and as spheres in the PAA matrix. The Young modulus and stress of the PAA/CNC nanocomposite fibers were significantly improved with increasing CNC loadings by up to 35-fold and 16-fold, respectively. Heat-induced esterification between the CNC surface hydroxyls and PAA carboxyl groups produced covalent crosslinks at the CNC-PAA interfaces, rendering the nanocomposite fibrous membranes insoluble in water, more thermally stable and far more superior in tensile strength. With 20% CNC, the crosslinked nanocomposite fibrous membrane exhibited a very impressive 77-fold increase in modulus and 58-fold increase in stress.

  13. Stabilization of the fibrous structure of an ?-helix-forming peptide by sequence reversal

    International Nuclear Information System (INIS)

    The ?3-peptide, which comprises three repeats of the sequence Leu-Glu-Thr-Leu-Ala-Lys-Ala and forms an amphipathic ?-helix, is unique among various ?-helix-forming peptides in that it assembles into fibrous structures that can be observed by transmission electron microscopy. As part of our investigation of the structure-stability relationships of the ?3-peptide, we synthesized the r3-peptide, whose amino acid sequence is the reverse of that of the ?3-peptide, and we investigated the effects of sequence reversal on ?-helix stability and the formation of fibrous structures. Unexpectedly, the r3-peptide formed a more-stable ?-helix and longer fibers than did the ?3-peptide. The stability of the r3-peptide helix decreased when the ionic strength of the buffer was increased and when the pH of the buffer was adjusted to 2 or 12. These results suggest that the r3-peptide underwent a 'magnet-like' oligomerization and that an increase in the charge-distribution inequality may be the driving force for the formation of fibrous structures

  14. Controlled antiseptic/eosin release from chitosan-based hydrogel modified fibrous substrates.

    Science.gov (United States)

    Romano, Ilaria; Ayadi, Farouk; Rizzello, Loris; Summa, Maria; Bertorelli, Rosalia; Pompa, Pier Paolo; Brandi, Fernando; Bayer, Ilker S; Athanassiou, Athanassia

    2015-10-20

    Fibers of cellulose networks were stably coated with N-methacrylate glycol chitosan (MGC) shells using subsequent steps of dip coating and photo-curing. The photo-crosslinked MGC-coated cellulose networks preserved their fibrous structure. A model hydrophilic antiseptic solution containing eosin, chloroxylenol and propylene glycol was incorporated into the shells to study the drug release dynamics. Detailed drug release mechanism into phosphate buffered saline (PBS) solutions from coated and pristine fibers loaded with the antiseptic was investigated. The results show that the MGC-coated cellulose fibers enable the controlled gradual release of the drug for four days, as opposed to fast, instantaneous release from eosin coated pristine fibers. This release behavior was found to affect the antibacterial efficiency of the fibrous cellulose sheets significantly against Staphylococcus aureus and Candida albicans. In the case of the MGC-eosin functionalized system the antibacterial efficiency was as high as 85% and 90%, respectively, while for the eosin coated pristine cellulose system the efficiency was negative, indicating bacterial proliferation. Furthermore, the MGC-eosin system was shown to be efficacious in a model of wound healing in mice, reducing the levels of various pro-inflammatory cytokines that modulate early inflammatory phase responses. The results demonstrate good potential of these coated fibers for wound dressing and healing applications. Due to its easy application on common passive commercial fibrous dressings such as gauzes and cotton fibers, the method can render them active dressings in a cost effective way. PMID:26256189

  15. Viet Nam [Status and technology of polymer-containing fibrous materials in the Eastern Hemisphere

    International Nuclear Information System (INIS)

    In South Viet Nam, forest covers about 30% of the land area or approximately 6 000 000 ha. Hardwoods comprise about 80% of the timber stock. The total growing stock is not known exactly. Forest inventory is difficult in Viet Nam since some areas are inaccessible in the virgin forest. Overcutting by the population for domestic uses should also be mentioned together with fire damage, destruction by the war, etc. Practically all species of fibrous wood which are common in South- East Asia grow in Viet Nam. Pine trees especially account for about 2% of the forest and bamboo for 1%, and rubber trees, kenaf and jute are abundant. Valuable fibrous materials other than wood are agricultural wastes such as rice straw and bagasse. Table I presents a list of the most common fibrous plants of Viet Nam; their importance, however, cannot be evaluated. In addition, restricted numbers of these plants are consumed by the population of the region where they grow wild. Exploitation is, in fact, purely artisanal and tends merely to meet local needs. Cotton plants (Gossipium herbaceum) grow mainly in Central Viet Nam; the cotton product is not of good quality since the fibres are not very long

  16. Study of fibrous plaques occurring in the coronary arteries of children.

    Science.gov (United States)

    Velican, D; Velican, C

    1979-06-01

    The pathology of the coronary arteries of children, in relation to atherosclerotic involvement, appeared as a pathology of the main emergence areas and branching points of the left coronary artery and particularly of the anterior descending artery. The first atherosclerotic lesions occurred as non-raised fibrous plaques in 2% of children 6--10 years old and in 4% of children and juveniles 11--15 years old. In the latter age group fatty streaks and gelatinous plaques were also seen in 6% of the subjects; in their appearance they lag behind fibrous plaques by 5--8 years. Indirect evidence was obtained that some branch pads or cushions might be converted into fibrous plaques. The transitional aspects included edema, histolysis (elastolysis, collagenolysis, ground-substance depletion and degenerative cell changes), followed by reorganization and homogeneization of the pre-existing heterogeneous microarchitecture; in a final stage the prevalent processes seemed to be the nodular proliferation of smooth muscle cells and the abundant neoformation of collagen fibers. In essence the results show that in atherosclerosis the coronary arteries are involved in a different sequence and histogenetic pattern than the aorta. PMID:475879

  17. The Philippines [Status and technology of polymer-containing fibrous materials in the Eastern Hemisphere

    International Nuclear Information System (INIS)

    Fibrous materials (timber and fibres) constitute one of the most steady dollar-earning industries in the Philippines. In 1966 the produce from this industry alone was worth 1061 million pesos, which was almost 6% of the country's national income. The total timber production amounted to 3 325 541 899 board feet, of which 15. 2% was consumed locally and the rest exported to different countries, with Japan as one of the largest importers. The Philippines produces quite a number of varieties of timber and fibre which have earned a good reputation for quality in the world market. However, there are also other varieties of timber and fibres which need improvement to gain a market. Plastic impregnation of these fibrous materials seems a very promising technique for improving their quality. Plastic impregnation of fibrous materials, being a relatively new field, has only recently been started in the Philippines. So far, only the Philippine Atomic Research Center (PARC) has been working in this field. Exploratory studies were initiated in November 1966. Initial work was confined to wood plastic combination (WPC)

  18. Bionic electrospun ultrafine fibrous poly(L-lactic acid) scaffolds with a multi-scale structure

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Kai; Wang Xuefen; Jing Dazheng; Yang Yin; Zhu Meifang, E-mail: wangxf@dhu.edu.c [State Key Lab for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai, 201620 (China)

    2009-06-15

    Poly(L-lactic acid) (PLLA) tissue engineering scaffolds with porous inner structures of individual fibers and controllable architectures were successfully fabricated from the homogeneous polymer-solvent-nonsolvent system (PLLA, CH{sub 2}Cl{sub 2} and DMF) by a single capillary electrospinning with certain conductive patterned templates as fiber collectors. PLLA was dissolved in dimethylformamide (DMF) and methylene chloride (CH{sub 2}Cl{sub 2}) mixed solvent with different ratios. Semi-hollow fiber with porous inner structure and compact shell wall was formed by controlling the content of DMF in the mixed solvents. It is believed that the phase separation should be the key origin for the formation of this microstructure. In order to mimic the natural extracellular matrix (ECM) with a specific structure, conductive patterned collectors were designed and employed to manufacture PLLA ultrafine fibrous scaffolds with three-dimensional architectures. We believe these kinds of multi-scale biodegradable fibrous scaffolds with specific microstructure and macro-architectures could make the electrospun fibrous scaffold better mimic the natural extracellular matrix to satisfy tissue engineering.

  19. Linking rock fabric to fibrous mineralisation: a basic tool for the asbestos hazard

    Directory of Open Access Journals (Sweden)

    G. Vignaroli

    2011-05-01

    Full Text Available In recent years, many studies have addressed the effect on human health caused by asbestos exposures. As asbestos is a group of fibrous minerals that mainly occurs in mafic and ultramafic rocks (ophiolitic sequences, a close relationship between asbestos occurrence and the geological history of host rocks should be expected. By reviewing the existing literature and presenting characteristic examples, it is proposed a direct correspondence exists between the presence of fibrous minerals in ophiolites and the rock fabric systematics due to the combined activity of deformation, metamorphism/metasomatism, and rock/fluid interaction. Understanding the geological factors that may be at the origin of the nucleation/growth of fibrous minerals constitutes a necessary requirement for developing a methodological and analytical procedure to evaluate asbestos hazard (AH in the natural prototype (ophiolitic rocks. A parameterisation of the AH in function of the main geological processes that produce the rock fabric systematics in different tectonic/geodynamic settings is discussed. A geological multidisciplinary approach (based on geological-structural field evidence combined with textural, mineralogical, petrological, and geochemical investigations is proposed as the prerequisite for the evaluation of AH in natural environments. This approach, in particular, can provide a robust basis to formulate a procedural protocol finalised to the mitigation of asbestos effects in environments where these effects are still a real threat.

  20. Fibrous dysplasia of the cranial vault: quantitative analysis based on neural networks

    International Nuclear Information System (INIS)

    To assess the utility of statistical analysis and neural networks in the quantitative analysis of fibrous dysplasia of the cranial vault. Ten patients with fibrous dysplasia (six women and four men with a mean age of 23.60卤17.85 years) were selected from a series of 167 patients with lesions of the cranial vault evaluated by plain radiography and computed tomography (CT). Nineteen variables were taken from their medical records and radiological study. Their characterization was based on statistical analysis and neural network, and was validated by means of the leave-one-out method. The performance of the neural network was estimated by means of receiver operating characteristics (ROC) curves, using as a parameter the area under the curve Az. Bivariate analysis identified age, duration of symptoms, lytic and sclerotic patterns, sclerotic margin, ovoid shape, soft-tissue mas and periosteal reaction as significant variables. The area under the neural network curve was 0.9601卤0.0435. The network selected the matrix and soft-tissue mass a variables that were indispensable for diagnosis. The neural network presents a high performance in the characterization of fibrous dysplasia of the cranial vault, disclosing occult interactions among the variables. (Author) 24 refs