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General Information about Osteosarcoma and Malignant Fibrous Histiocytoma of Bone  

Science.gov (United States)

General Information About Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Osteosarcoma and malignant fibrous histiocytoma (MFH) of the bone are diseases in which malignant (cancer) cells form ...

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Malignant fibrous histiocytoma of the soft tissues  

International Nuclear Information System (INIS)

Malignant fibrous histiocytomas are uncommon tumors which are frequently indistinguishable from many other diseases. The authors report two cases of a malignant fibrous histiocytoma of soft tissues, one originated at the retroperitoneum and another at the thigh. They discuss the differential diagnosis and the role of radiologic methods in its diagnosis. (author)

1991-01-01

3

Radiation-induced intracranial malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

An autopsy case of radiation-induced intracranial malignant fibrous histiocytoma (fibroxanthosarcoma) is reported. The tumor developed in the region of the sella turcica 11 years after high dose radiotherapy of a chromophobe adenoma of the pituitary. The tumor had infiltrated the base of the brain as well as the base of the skull. Metastases were not found. The tumor was composed of an admixture of bizarre fibroblasts, histiocytes and giant cells, xanthoma cells and siderophages, with a storiform fibrous stroma. This appears to be the first documented instance of a malignant fibrous histiocytoma occurring intracranially after local x irradiation

1976-01-01

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Malignant fibrous histiocytoma of soft tissue  

International Nuclear Information System (INIS)

Computed tomography was performed in 27 patients with confirmed malignant fibrous histiocytoma of the soft tissue. Compared with the CT results obtained in other tumours of the soft tissues, CT accuracy in malignant fibrous histiocytoma was only 74%. Non-typical attenuation values, diffuse tumour growth and non-typical contrast enhancement are discussed as reasons for the diagnostic understaging or overstaging of these soft tissue tumours. A higher accuracy was found on ultrasound examination with regard to tumour extension. Bone destruction was better visualised by CT. A base-line CT is recommended postoperatively for the earlier detection of recurrent tumours in further investigations. (orig.)

1988-01-01

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Malignant Fibrous Histiocytoma Arising from Nasal Cavity  

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Full Text Available The present aim is to report a case of malignant fibrous histiocytoma of the nasal cavity in a 64-year-old woman. This is a rare entity in the head and neck region. The patient referred with nasal obstruction and underwent wide surgical resection with negative margin. He is well with no evidence of disease for 36 months after surgery.

Mohammad Ali Damghani

2008-01-01

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Malignant fibrous histiocytoma of the bone (radiodiagnosis)  

International Nuclear Information System (INIS)

Clinical and X-ray signs of malignant fibrous histiocytoma of the bone were described on the basis of a literature analysis and 12 observations. From the roentgenological view-point various tumor symptoms can fall into 2 types and 2 variants

1985-01-01

7

Malignant Fibrous Histiocytoma in the Infratemporal Fossa  

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Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in late adult life, but its incidence in oral and maxillofacial region is extremely rare. We report a case of malignant fibrous histiocytoma which occurred in the infratemporal fossa. Conventional radiograph of this case showed an ill-defined radiolucent lesion in the alveolar bone of the right maxillary first molar area, the lateral wall of the maxillary sinus, and the ascending ramus of mandible. MRI demonstrated well defined mass of intermediate signal intensity in T1 weighted images but T2 weighted images showed two distinctive regions of different characteristics. Infratemporal portion of the lesion was of hyperintense signal but under that region, the signal intensity decreased clearly, which might mean this case composed of two different subtypes, though it couldn't be confirmed by histopathological examination. Biopsy was taken in the only soft tissue of the maxillary posterior alveolar region and confirmed the lesion as the storiform-pleomorphic type of malignant fibrous histiocytoma. Histopathological subtype was well consistent with the relatively aggressive imaging findings of that region. We expect more detailed analysis of the nature of malignant fibrous histiocytoma with improvement of the imaging modality and the identification of the relationship between diagnostic imaging and histopathologic findings.

Lee, Kyung Hee; Heo, Min Suk; Lee, Sam Sun; Choi, Soon Chul [Dept. of Oral and Maxillofacial Radiology and Dental Research Institute, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

1999-08-15

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Malignant Fibrous Histiocytoma in the Infratemporal Fossa  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in late adult life, but its incidence in oral and maxillofacial region is extremely rare. We report a case of malignant fibrous histiocytoma which occurred in the infratemporal fossa. Conventional radiograph of this case showed an ill-defined radiolucent lesion in the alveolar bone of the right maxillary first molar area, the lateral wall of the maxillary sinus, and the ascending ramus of mandible. MRI demonstrated well defined mass of intermediate signal intensity in T1 weighted images but T2 weighted images showed two distinctive regions of different characteristics. Infratemporal portion of the lesion was of hyperintense signal but under that region, the signal intensity decreased clearly, which might mean this case composed of two different subtypes, though it couldn't be confirmed by histopathological examination. Biopsy was taken in the only soft tissue of the maxillary posterior alveolar region and confirmed the lesion as the storiform-pleomorphic type of malignant fibrous histiocytoma. Histopathological subtype was well consistent with the relatively aggressive imaging findings of that region. We expect more detailed analysis of the nature of malignant fibrous histiocytoma with improvement of the imaging modality and the identification of the relationship between diagnostic imaging and histopathologic findings.

1999-08-01

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Postirradiation sarcoma (malignant fibrous histiocytoma) following cervix cancer  

International Nuclear Information System (INIS)

A case of postirradiation sarcoma is described. The tumor, a malignant fibrous histiocytoma, occurred in the radiation field 11 years following postoperative external beam radiation therapy (7,000 rad) for carcinoma of the cervix. Reports of postirradiation malignant fibrous histiocytoma are rare, and the occurrence of this neoplasm following treatment for cervix cancer has not previously been described. The literature concerning postirradiation bone and soft tissue sarcomas is briefly reviewed, with special attention to malignant fibrous histiocytomas. (author)

1980-01-01

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Gallium scanning in malignant fibrous histiocytoma  

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Malignant fibrous histiocytoma (MFH) is a recently defined, well established clinical and pathologic entity. Five patients with MFH who had gallium-67 scans are described. An attempt is made to correlate the presence, abscence, and extent of disease, as both primary and metastatic deposits showed avidity for gallium-67. After excision, patients with negative gallium scans were well, while metastatic disease was shown by gallium scans in two patients shortly before death. Gallium scanning is advocated for initial evaluation and follow-up of patients with MFH.

Zazzaro, P.F.; Bosworth, J.E.; Schneider, V.; Zelenak, J.J.

1980-10-01

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Gallium scanning in malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma (MFH) is a recently defined, well established clinical and pathologic entity. Five patients with MFH who had gallium-67 scans are described. An attempt is made to correlate the presence, abscence, and extent of disease, as both primary and metastatic deposits showed avidity for gallium-67. After excision, patients with negative gallium scans were well, while metastatic disease was shown by gallium scans in two patients shortly before death. Gallium scanning is advocated for initial evaluation and follow-up of patients with MFH

1980-01-01

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Malignant Fibrous Histiocytoma Of Bone After Humerus Fracture  

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A case of humerus fracture associated with malignant fibrous histocytoma in an 83 year old woman is presented. Malignant fibrous histiocytoma of the bone, is a condition that involves the humerus in 8% of cases and represents less than 1% of primary bone tumours. The patient with humeral shaft fracture treated with Hackethal’s technique was presented three months later with tumefaction of the arm and osteolysis in the radiograph. Diagnosis of malignant fibrous histiocytoma of the bone after...

2007-01-01

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A postirradiation, myxoid type, malignant fibrous histiocytoma  

International Nuclear Information System (INIS)

The authors discuss the case of a 59-year-old man who presented a mass in the dorsum of his right foot. He previously had had a hemangioma in this region from birth, and at the age of 10, radiation therapy had been administered to this region because of an ulcer that had developed. Additionally, so as to cover the ulcer, he had been given a free skin graft and a cross-leg flap. Some 50 years after this radiation, he noticed a mass in his foot, and a microscopic examination of a biopsied specimen of this mass revealed it to be a myxoid type, malignant fibrous histiocytoma (MFH). Thus, a below-the-knee amputation was performed. To the best of their knowledge, the authors report that 29 cases of an MFH developing after radiotherapy have been reported in the Japanese literature, and an analysis of these 29 cases is provided and the details of this case are given. (author)

1993-09-01

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Primary Malignant Fibrous Histiocytoma: A Rare Case  

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Malignant fibrous histiocytoma (MFH) of the small intestine is an extremely rare condition. It occurs most commonly in the extremities and the trunk. We report a case of a 67-year-old woman who admitted with fever, myalgia, and altered status. After thorough investigation, a tumor of the jejunum was found. The patient underwent complete surgical removal of the tumor. A diagnosis of MFN (undifferentiated high-grade pleomorphic sarcoma) was made. The patient received adjuvant chemotherapy with Gemcitabine. Two years after the operation, the patient died due to recurrence of the disease. MFH of the small intestine is an extremely rare neoplasm with an aggressive biological behaviour. In this paper, pathogenesis, natural history, and treatment are reviewed.

Katsourakis, Anastasios; Noussios, George; Hadjis, Iosif; Evangelou, Neofitos; Chatzitheoklitos, Efthimios

2011-01-01

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General Information About Osteosarcoma and Malignant Fibrous Histiocytoma of Bone  

Science.gov (United States)

... abdomen . Osteosarcoma is the most common type of bone cancer . Malignant fibrous histiocytoma (MFH) of bone is a ... like osteosarcoma. Ewing sarcoma is another kind of bone cancer, but it is not covered in this summary. ...

16

Primary malignant fibrous histiocytoma of the mesentery: a case report  

International Nuclear Information System (INIS)

A malignant fibrous histiocytoma of the mesentery is rare, and multifocal involvement as a primary tumor is very rare. In this report, a case of malignant fibrous histiocytoma of the mesentery presenting with two masses and multiple peritoneal seeding in a 48-year-old man is described. A physical examination revealed a large, firm, and non-tender mass in the right lower abdomen of the patient. Computed tomography of the lesion revealed a partially, indistinctly marginated and heterogeneously enhancing mass with irregular peritumoral strands in the mesentery of the right lower abdomen, while sonograms of the lesion revealed an ill-defined low-echoic mass. The final pathology demonstrated the presence of a storiform-pleomorphic malignant fibrous histiocytoma

2007-12-01

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A case of postirradiated malignant fibrous histiocytoma of the vagina  

International Nuclear Information System (INIS)

An unusual case of postirradiated malignant fibrous histiocytoma of the vagina in a 72-year-old female is reported. The tumor occurred in the radiation field 30 years after radical hysterectomy and preoperative radiation therapy (radium 5,200 mgh) for squamous cell carcinoma of the uterine cervix. She had been disease free for 30 years until she noticed a large mass in the vagina. Cytological study showed mainly two types of non-epithelial malignant cells; spindle-shaped fibroblast-like cells and histiocyte-like cells. Bizarre mono or multinucleated giant cells were often observed. The operative specimen revealed an arrangement composed of short or long spindle cells and vacuolated mononucleated and large multinucleated cells. The diagnosis was comfirmed by immunohistological and ultrastructural study. We have reviewed the literature on malignant fibrous histiocytoma occurring after radiation for cervical carcinoma. (author)

1992-11-01

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Malignant Fibrous Histiocytoma Arising from the Omentum Presenting as Hemoperitoneum  

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Malignant fibrous histiocytoma (MFH) is an uncommon soft-tissue sarcoma that occurs primarily in the extremities and rarely involves the retroperitoneum and abdomen. A 63-year-old man was admitted to the emergency room because of epigastric pain. Computed tomography revealed a large heterogeneous enhanced mass originating from the omentum with hemoperitoneum. The patient underwent laparoscopic omental mass excision and hematoma evacuation. Histological examination of the resected tumor reveal...

Kweon, Ji Hye; Choi, Chang Soo; Im, Chong Ju; Seo, Geom Seog; Choi, Suck Chei

2010-01-01

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Malignant fibrous histiocytoma originating from the mesorectum: a case report  

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Abstract Background Malignant fibrous histiocytoma (MFH) is a common sarcoma affecting soft tissues of the body, especially of the extremities or trunk. Prognosis of the abdominal MFH is usually poor. Case presentation A 52-year-old female presented to our surgical outpatient clinic with a lower abdominal tumor that had been gradually increasing in size. Clinical examination revealed a firm, irregularly surfaced, fixed, painless, child-head-sized tumor located i...

Nakayama Yoshifumi; Minagawa Noritaka; Torigoe Takayuki; Yamaguchi Koji

2011-01-01

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Malignant fibrous histiocytoma of the pulmonary artery -a case report-  

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We recently experienced a case of primary malignant fibrous histiocytoma of the left pulmonary artery occurred in a 27-year-old man who had 5 months history of intermittent hemoptysis. Chest X-ray revealed multilobulated mass density (about 4x5cm in size) in left hilar area, and another small lobulated nodular density (about 1x1.5cm in size) in left upper lung field, which was intrapulmonary metastatic deposit. CT scan, pulmonary arteriography, and selective left bronchial arteriography after partial resection of the left hilar mass and left upper lobectomy revealed the mass to have the characteristic feature.

Kweon, Young Hwa; Joo, Jeong Hee; Nam, Myung Hyun; Jeon, Seok Chol; Seo, Heung Suk; Lee, Jung Hee; Park, Sung Soo [College of Medicine, Hanyang University, Seoul (Korea, Republic of)

1987-12-15

 
 
 
 
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Malignant fibrous histiocytoma of the lower lip: A case report  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant fibrous histiocytoma (MFH represents the diagnosis that is still commonly used by both patients and physicians although in 2002., the World Health Organization (WHO declassified MFH as a formal diagnostic entity, renaming it as an undifferentiated pleomorphic sarcoma not specifying it further. MFH is extremely rare in the oral cavity. The aim of this article was to describe a newly diagnosed case of primary MFH in a 78-year-old male presented after 4-months history of rapidly increasing swelling of lower lip. Histopathology of the lesion showed highly malignant cell infiltration with epithelioid/spindle cell type morphology. Immunohistochemical study was positive for vimentin (++, S-100 protein (++ and negative for desmin and cytokeratin. The authors discussed the possibilities of immunohistochemical study and necessity of individual treatment plan in patients with MFH, comparing their point of view with other studies.

Pechalova Petia F

2012-01-01

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Malignant fibrous histiocytoma of the spine causing spinal neural foramen widening.  

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A case with a clinical picture of a chronic low back pain radiating to both lumbar regions caused by malignant fibrous histiocytoma is reported. Radiological, surgical and histopathological findings and treatment of this rare case are discussed. PMID:10940610

Karantanas, A H; Hytiroglou, P; Zibis, A H; Markonis, A; Papadimitriou, C S

2000-01-01

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Cytokines in inflammatory malignant fibrous histiocytoma presenting with leukemoid reaction.  

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Inflammatory malignant fibrous histiocytomas (IMFH) are rare tumors and are frequently associated with leukocytosis. In rare cases, leukemoid reactions were attributed to tumor production of unidentified hematopoietic factors. In this study, we used immunohistochemical techniques to show cytokine immunoreactivity in the malignant cells of two cases of IMFH presenting with leukemoid reactions and compared them with two malignant fibrous histocytomas, noninflammatory type. All four tumors stained positively for stem cell factor (SCF), granulocyte colony-stimulating factor (G-CSF), interleukin-2 (IL-2), IL-4, IL-5, interferon-alpha (IFN-alpha), and insulin-like growth factor-I. Other cytokines detected only in the two IMFH included IL-6, IL-7, IL-8, IFN-gamma, and keratinocyte growth factor. Granulocyte-macrophage-CSF, IL-3, and transforming growth factor-beta staining was present in one of the two IMFH tumors and was not present in the noninflammatory tumors. The immunohistochemical staining was localized to the malignant cells, suggesting deregulated cytokine expression consistent with their monocytic/histocytic origin. Expression of certain cytokines in the IMFH may account for the local inflammatory infiltrate, tumor fibrosis, and the aggressive nature of the malignant cells. We also detected elevated serum levels of SCF, G-CSF, IL-6, and tumor necrosis factor in one or both of the IMFH patients. These latter observations may explain the bone marrow hypercellularity and other paraneoplastic symptoms, including fever, malaise, and weight loss, observed in both patients. Different cytokines present in the two IMFH tumors appear to be responsible for the eosinophilic leukemoid reaction observed in one case and for the granulocytic leukemoid reaction observed in the other patient. They may also be responsible for expansion of the tumor-cell population, fibroblast proliferation, and enhanced secretion of extracellular collagen. PMID:7691245

Melhem, M F; Meisler, A I; Saito, R; Finley, G G; Hockman, H R; Koski, R A

1993-10-01

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Malignant fibrous histiocytomas and H-ras-1 oncogene point mutations.  

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AIMS: To investigate the types and the frequencies of H-ras-1 gene mutations in malignant fibrous histiocytomas. METHODS: Thirty five samples of malignant fibrous histiocytoma tissue were searched for point mutations within "hot spot" codons 12 and 13 of the H-ras-1 oncogene by the specific "nested" polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) and a direct cycle sequencing procedure. RESULTS: In contrast to previous reports, none of...

1999-01-01

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MALIGNANT FIBROUS HISTIOCYTOMA OF THE PENIS A CASE REPORT AND REVIEW OF THE LITERATURE  

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Penile malignant fibrous histiocytoma is an extremely rare tumor. To the best of our knowledge, we present here the fifth primary malignant fibrous histiocytoma of the penis. The patient presented with lung metastasis which initially responded well to systemic chemotherapy with Adriamycin and Ifosfamide, but recurred soon after. The local lesion did not respond to chemotherapy and the patient had to undergo a palliative penectomy. The disease progressed rapidly and the patient died one year a...

2009-01-01

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Histiocitoma fibroso maligno / Histiocytome fibreux malin / Malignant fibrous histiocytoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Introducción: los sarcomas son tumores malignos de partes blandas que representan 0,7 % de los tumores malignos en general, con una tasa de 3 por cada 100 000. El histiocitoma fibroso maligno resulta un tumor de alto grado incluido en el grupo de los sarcomas de partes blandas. Objetivo: exponer las [...] características citohistológicas, el tratamiento y la evolución de este tumor en un caso estudiado y tratado en el Hospital General Provincial Docente "Roberto Rodríguez Fernández" de Ciego de Ávila. Descripción: se presentó el caso de un varón de 60 años con una gran masa de partes blandas en el muslo izquierdo, de crecimiento progresivo. La masa se trató quirúrgicamente con exéresis en bloque, previos estudios analíticos, arteriografía femoral y ecografía. Conclusiones: el diagnóstico anatomopatológico fue de histiocitoma fibroso maligno variedad pleomórfica; fue remitido al servicio de oncología donde lo trataron con radioterapia. A los 6 meses se encontraba libre de la enfermedad. Se realizó una revisión de la literatura y se analizó su presentación clínica, también los hallazgos histológicos, las pruebas diagnósticas de imagen y el procedimiento terapéutico. Abstract in english Introduction: the sarcomas are soft tissue malignant tumors accounting for the 0.7 % of malignant tumors in general with a rate of 3 by 100 000. The malignant fibrous histiocytoma is a high grade tumor included in the group of soft tissue tumors. Objective: to expose the cytohistologic features, tre [...] atment and course of this tumor in study case and treated in "Roberto Rodríguez Fernández" Teaching Provincial Hospital of Ciego de Avila municipality. Description: this is the case of a male patient aged 60 presenting with an increasing large soft tissue mass in the left thigh. The mass was operated on with block exeresis, analytical previous studies, femoral arteriography and echography. Conclusions: the anatomic and pathologic diagnosis was a malignant fibrous histiocytoma pleomorphous type; the patient was referred to Oncology service where was treated with radiotherapy. At 6 months he was free of disease. A review of literature was performed analyzing its clinical presentation also, its histological findings, the imaging diagnostic test and the therapeutical procedure.

Hiralio, Collazo Álvarez; Dewar, Torrecilla Silverio; Jorge Luis, Morales Florat; Stephens Yecc, Collazo Marín.

27

Postirradiation sarcoma (malignant fibrous histiocytoma) following uterine cervical cancer  

International Nuclear Information System (INIS)

A case of postirradiation sarcoma, a malignant fibrous histiocytoma, is described. The tumor occurred in the radiation field (the buttock) 8 years after radiation therapy for keratinizing squamous cell carcinoma of the uterine cervix. The 68-year-old female patient with the inital diagnosis of cervical cancer was treated with pelvic irradiation in 1973. She did well after that with no evidence of disease until 1981 when she developed an enlarging mass in the right buttock within the field of the previous radiation therapy. Microscopically, the tumor at biopsy was composed of pleomorphic histiocyte-like cells, spindle-sphaped cells arranged in a storiform pattern and multinucleated giant cells with bizarre nuclei. Cytodiagnostically, two types of cells, fibroblast-like cells ane histiocyte-like cells, were found. And some cells were considered to be transitional forms, intermediate between fibroblast and histiocytes. Multinucleated pleomorphic giant cells were sometimes seen. Ultrastructurally, the same types of cells were confirmed. These cells contained large numbers of rough endoplasmic reticula with dilated lumens, vacuoles, lysosomal structures, and lipid droplets. (author)

1984-01-01

28

Clinical analysis of 10 patients with primary malignant fibrous histiocytoma of the lung  

International Nuclear Information System (INIS)

Objective: Objective To study the treatment method and prognosis of primary malignant fibrous histiocytoma of the lung. Methods: Ten patients with primary malignant fibrous histiocytoma of the lung proved by histopathology were reviewed retrospectively. Five were treated by surgery alone, 3 by postoperative radiotherapy and 2 by postoperative chemotherapy. Results: Six of ten patients were able to survive more than 1 year. Four of the six survived more than 2 years and 3 more than 3 years. The 1-, 2-year survival rates were 60% and 40%, respectively. The relapse sites after treatment included: local recurrence (n=1); distant metastasis (n=1) and local recurrence plus distant metastasis (n=3), the interval ranging from 1 to 18 months. Conclusions: The prognosis of primary malignant fibrous histiocytoma of the lung is poor. Surgery is the main treatment method. The role of either postoperative radiation therapy or chemotherapy remains unclear. (authors)

2004-09-01

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Haematoma-like primary intracranial malignant fibrous histiocytoma in a 5-year-old girl  

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We present CT and MRI of an intracranial malignant fibrous histiocytoma in a 5-year-old girl with headache and vomiting. This case is unusual particular by virtue of its radiological appearances and the young age of the patient. (orig.)

Oezhan, S.; Tali, E.T.; Isik, S.; Saygili, M.R. [Gazi Univ., Dept. of Radiology, Ankara (Turkey); Baykaner, K. [Gazi Univ., Dept. of Neurosurgery, Ankara (Turkey)

1999-07-01

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Malignant fibrous histiocytoma of soft tissue with metaplastic bone and cartilage formation  

International Nuclear Information System (INIS)

The presence of bone and cartilage in some cases of malignant fibrous histiocytoma of the soft tissue as a microscopic finding has been reported previously but little note has been taken of the radiologic manifestations of these tumor elements. A series of five such cases with sufficient metaplastic osseous and cartilaginous elements to produce roentgenographic evidence of their presence is reported here. An additional two cases showed only histologic evidence of bone or cartilage formation. The reactive ossification tends to be peripheral in location, involving the pseudocapsule of the sarcoma or its fibrous septa. In three there was a zoning pattern with peripheral or polar orientation, strongly suggesting the diagnosis of myositis ossificans. The latter was the diagnosis considered radiologically in four of the five cases. Malignant fibrous histiocytoma with reactive bone and cartilage must be considered in the differential diagnosis of soft tissue masses with calcific densities, particularly when these occur in tumors of the extremities. (orig.)

1982-01-01

31

Malignant fibrous histiocytoma of soft tissue with metaplastic bone and cartilage formation  

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The presence of bone and cartilage in some cases of malignant fibrous histiocytoma of the soft tissue as a microscopic finding has been reported previously but little note has been taken of the radiologic manifestations of these tumor elements. A series of five such cases with sufficient metaplastic osseous and cartilaginous elements to produce roentgenographic evidence of their presence is reported here. An additional two cases showed only histologic evidence of bone or cartilage formation. The reactive ossification tends to be peripheral in location, involving the pseudocapsule of the sarcoma or its fibrous septa. In three there was a zoning pattern with peripheral or polar orientation, strongly suggesting the diagnosis of myositis ossificans. The latter was the diagnosis considered radiologically in four of the five cases. Malignant fibrous histiocytoma with reactive bone and cartilage must be considered in the differential diagnosis of soft tissue masses with calcific densities, particularly when these occur in tumors of the extremities.

Dorfman, H.D.; Bhagavan, B.S.

1982-05-01

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Frequent expression of smooth muscle markers in malignant fibrous histiocytoma of bone  

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Background/Aims: Malignant fibrous histiocytoma (MFH) of bone, a relatively rare primary malignant bone tumour, is a distinct clinicopathological entity as opposed to MFH derived from soft tissue. Although the true histogenesis of this condition is still controversial, a considerable number of cases of MFH in soft tissue show positive immunohistochemical reactivity for muscle markers such as desmin, common muscle actin (HHF35), and ? smooth muscle actin (SMA), suggesting that MFH cells are m...

2002-01-01

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Primary Giant Cell Malignant Fibrous Histiocytoma of the Kidney with Staghorn Calculi  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant fibrous histiocytomas (MFH as primary renal tumours are rare, with less than 50 cases described in the literature. We report a case of primary renal MFH of giant cell type in a 56-year-old man, who presented with bilateral dull flank pain, intermittent gross haematuria and body weight loss (6 kg in 3 months. Intravenous urography, computerized tomography (CT and magnetic resonance image (MRI showed right ureteral stones with mild hydronephrosis, and a solid mass at the lower pole of the left kidney associated with staghorn calculi, as well as tumour thrombi in the left renal vein and inferior vena cava. Left radical nephrectomy and evacuation of tumour thrombi from the left renal vein and inferior vena cava were performed. Histopathologic examination revealed malignant fibrous histiocytoma (MFH of giant cell type. To the best of our knowledge, this is the first report of primary renal MFH associated with staghorn calculi.

Chen C

2003-01-01

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Primary Malignant Fibrous Histiocytoma of the Kidney: Report of a Case  

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Full Text Available Primary renal malignant fibrous histiocytoma is extremely rare. The prognosis is generally poor because of the high rate of local recurrence even if radical surgery is performed. We report a case of primary renal malignant fibrous histiocytoma in a 43-year-old woman.A well-defined renal mass (10x9x7cm with lobulated contour was revealed by abdominal ultrasonography and computerized tomography in our patient who presented with left-flank pain. The contralateral kidney and renal functions were normal. No other primary tumor focus was detected by screening performed to exclude a metastasis to the kidney. However, a nodule consistent with metastasis was identified in the liver. The patient underwent left radical nephrectomy. A huge, yellowish-white, partly necrotic neoplasm infiltrating the renal parenchyma, perirenal fat and adrenal tissue was revealed by gross examination. Microscopically, the tumor was composed of pleomorphic spindle to polygonal cells arranged in fascicles and storiform structures with extensive necrosis. Twelve mitotic figures were noted in 10 high power fields. Immunohistochemical staining for vimentin and CD68 were positive whereas pan-cytokeratin, smooth muscle actin, S-100, HMB-45 and desmin were negative. “A pleomorphic type of malignant fibrous histiocytoma” was diagnosed based on both the microscopic and immunohistochemical findings. The patient presented with multiple bilateral lung metastasis three years after nephrectomy.Histopathological examination is essential since malignant fibrous histiocytoma cannot be differentiated clinically and radiologically from other lesions with kidney involvement. The overall prognosis is unfavorable with a recurrence rate of more than 50% and the 5-yearsurvival rate is only 14%.

Nilay ?EN TÜRK

2010-05-01

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An 11 kg Malignant Fibrous Histiocytoma in a 54-Year-Old Patient: A Case Report  

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Background and Objectives: Malignant fibrous histiocytoma (MFH) is a soft tissue sarcoma of undifferentiated mesenchymal cell origin which is considered the most common soft tissue sarcoma in adults. It commonly occurs in the 5th and 6th decades with a 2-to-1 male to female ratio. It most frequently occurs in the extremities and retroperitoneum. Most of it is derived from soft tissues and some of it from b...

Ghadir, M. R.

2012-01-01

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Simultaneous occurrence of malignant fibrous histiocytoma and hepatocellular carcinoma in cirrhotic liver: A case report  

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Primary hepatic malignant fibrous histiocytoma (MFH) is rarely encountered. There have been no reports to date of hepatic MFH associated with liver cirrhosis. The presence of liver cirrhosis is considered an adjunctive feature favoring sarcomatoid hepatocellular carcinoma (HCC) in the diagnosis of spindle cell tumors in liver. We describe here a 59-year-old man with liver cirrhosis due to hepatitis B virus infection 20 years ago. On abdominal computed tomography scanning, two distinct hepatic...

2011-01-01

37

Nuclear magnetic resonance studies on malignant fibrous histiocytoma. Evaluation of the effectiveness of chemotherapy in anticancer drug  

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The relaxation times of water protons in the tissues of malignant fibrous histiocytoma (MFH) and the tumor treated with adriamycin (adriamycin-treated MFH) were studied in rats as a model of human MFH by nuclear magnetic resonance. Using the values of the malignancy index derived from the relaxation times of these tumors, it has been possible to discriminate clearly between MFH tissue and non-malignant tissue, and to evaluate the effectiveness of anticancer drug. The malignancy index, furthermore, was compatible with the histological evaluation of the effectiveness of chemotherapy in an adriamycin-treated malignant fibrous histiocytoma.

Shimomura, Yoshifumi; Yamasaki, Masaki

1987-12-01

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[A case report of malignant fibrous histiocytoma arising from the renal capsule].  

Science.gov (United States)

A 58-year-old woman was found to have a tumor of the left kidney by ultrasonography and x-ray at a medical examination. Computed tomography showed a mass with calcification adjacent to the left kidney. The patient was successfully treated with open nephrectomy. Pathological examination revealed the malignant fibrous histiocytoma (MFH) arising from the renal capsule, striform-pleomorphic type, low grade malignancy. She was free of disease at fourteen months postoperatively. To our knowledge, this is the 26th case of MFH arising from the renal capsule in Japan. PMID:24322412

Matsushita, Makoto; Okada, Takayuki; Kawamura, Norihiko; Ujike, Takeshi; Nin, Mikio; Tsujihata, Masao

2013-11-01

39

Osteosarcoma and malignant fibrous histiocytoma of bone. Diagnostic and therapeutic aspects with special reference to chemotherapy and surgery.  

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This thesis is composed of seven articles dealing with several diagnostic and therapeutic aspects of bone tumors.Osteosarcoma and malignant fibrous histiocytoma (MFH) of bone received special attention. These two malignant primary bone tumors have grade of malignancy, predeliction side, and sensitivity to chemotherapy common. As a consequence, there are no essential differences in treatment. ...

Heeten, Gerard Johan Den

1987-01-01

40

Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma  

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Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-Kras[superscript G12D]; Trp53[superscript Flox/Flox] mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 in human MFH. Expression of Foxm1 is elevated in mouse sarcomas that metastas...

Mito, Jeffrey K.; Riedel, Richard F.; Dodd, Leslie; Lahat, Guy; Lazar, Alexander J.; Dodd, Rebecca D.; Stangenberg, Lars; Eward, William C.; Brigman, Brian E.; Jacks, Tyler; Lev, Dina; Mukherjee, Sayan; Kirsch, David G.; Aziz, Syed A.; Hornicek, Francis John

2009-01-01

 
 
 
 
41

Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma  

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Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the \\(LSL\\)-\\(Kras^{G12D}\\); \\(Trp53^{Flox/Flox}\\) mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 in human MFH. Expression of \\(Foxm1\\) is elevated in mouse sarcomas that metastasize to...

Mito, Jeffrey K.; Riedel, Richard F.; Dodd, Leslie; Lahat, Guy; Lazar, Alexander J.; Dodd, Rebecca D.; Stangenberg, Lars; Eward, William C.; Brigman, Brian E.; Jacks, Tyler; Lev, Dina; Mukherjee, Sayan; Kirsch, David G.; Aziz, Syed A.; Hornicek, Francis John

2009-01-01

42

Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-KrasG12D; Trp53Flox/Flox mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 in human MFH. Expression of Foxm1 is elevated in mouse sarcomas that metastasize to the lung and tissue m...

Mito, Jeffrey K.; Riedel, Richard F.; Dodd, Leslie; Lahat, Guy; Lazar, Alexander J.; Dodd, Rebecca D.; Stangenberg, Lars; Eward, William C.; Hornicek, Francis J.; Yoon, Sam S.; Brigman, Brian E.; Jacks, Tyler; Lev, Dina; Mukherjee, Sayan; Kirsch, David G.

2009-01-01

43

A case of malignant fibrous histiocytoma of the pancreas: computed tomography (CT) and ultrasound (US) appearance  

International Nuclear Information System (INIS)

The case of a 50-year-old female with a malignant fibrous histiocytoma of the pancreas is presented. This was diagnosed pre-operatively on ultrasound and computed tomography (CT). The lesion encircled the body and tail of the pancreas and appeared as a large inhomogeneous mass with polycyclic and well-defined margins. Contrast-enhanced CT examination showed marked but inhomogeneous enhancement. The tomodensitometric characteristics plus the lack of lymphnodal or hepatic metastases indicated the sarcomatous nature of the mass before the surgical approach. (orig.)

1993-01-01

44

Imaging findings, prevalence and outcome of de novo and secondary malignant fibrous histiocytoma of bone  

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To evaluate the radiographic and magnetic resonance (MR) imaging features of primary and secondary malignant fibrous histiocytoma in bone and determine the demographics, prevalence and outcome of patients with this tumor. A retrospective search of files from two institutions identified 28 patients with malignant fibrous histiocytoma (MFH) of bone. Microscope slides were reviewed to confirm diagnosis and identify any pre-existing lesions. Medical records were reviewed with respect to patients' demographic characteristics and outcomes. Radiographic features demonstrated an aggressive osteolytic lesion with a permeative pattern of bone destruction. Periosteal reaction was seen in three of 13 lesions. T1-weighted images (T1WIs) demonstrated signal intensity iso- to slightly hyperintense to muscle. T2-weighted images (T2WIs) demonstrated mildly higher signal intensity than that of muscle. The 5-year survival rate was 53%. The tumor arose secondarily in pre-existing lesions in 43% of patients. Metastases occurred in 46% of patients during the course of the disease, with pulmonary and osseous metastases being the most common. Secondary MFH of bone was slightly less common than primary MFH and had a prognosis similar to that of primary MFH of bone. MR imaging showed variable and somewhat unusual low to intermediate T2 signal characteristics for a radiographically malignant osteolytic lesion. (orig.)

Koplas, Monica C.; Ilaslan, Hakan; Sundaram, Murali [Cleveland Clinic, Imaging Institute/A21, Cleveland, OH (United States); Lefkowitz, Robert A.; Landa, Jonathan [Memorial Sloan-Kettering Cancer Center, Department of Radiology, New York, NY (United States); Bauer, Thomas W. [Cleveland Clinic, Anatomic Pathology/L25, Cleveland, OH (United States); Joyce, Michael J. [Cleveland Clinic, Orthopaedic and Rheumatologic Institute/A41, Cleveland, OH (United States)

2010-08-15

45

Primary malignant fibrous histiocytoma of the breast: report of one case  

Directory of Open Access Journals (Sweden)

Full Text Available Caigang Liu,1 Zuowei Zhao,1 Qingfu Zhang,2 Yunfei Wu,3 Feng Jin3 1Department of Breast Surgery, Second Hospital of Dalian Medical University, Dalian, People's Republic of China; 2Department of Pathology, First Hospital of China Medical University, Shenyang, People's Republic of China; 3Department of Breast Surgery, General Surgery, First Hospital of China Medical University, Shenyang, People's Republic of China. Abstract: Seven years ago, a 48-year-old female patient discovered a painless tumor in her right breast simply by chance. In the next year, the tumor increased significantly in size. At this point, the patient received a tumor resection, which was misdiagnosed as a benign mesenchymal tissue-originated tumor. Unfortunately, the tumor recurred just 10 days after resection. We subsequently resected the recurrent lesion and confirmed primary breast malignant fibrous histiocytoma. The tumor began to exhibit an unprecedented, massive, and uncontrolled growth, ulcerating soon after the operation. Treatment of the patient was limited by time. After the patient received a cycle of chemotherapy, she died of cachexia with the emergence of multiorgan metastasis 2 months after the operation. Keywords: breast, primary malignant fibrous histiocytoma, treatment, survival

Liu C

2013-04-01

46

A malignant fibrous histiocytoma after radical mastectomy with radiotherapy. A case report  

International Nuclear Information System (INIS)

A rare case of radiation induced malignant fibrous histiocytoma is presented. A 57-year-old woman noticed a rapidly enlarging tumor with itch in the left supraclavicular region and visited another hospital. There was a previous history of undergoing a radical mastectomy with radiotherapy for a left breast cancer at elsewhere (no clear information on clinical stage and dose of radiation was obtained). The patient was referred to the hospital. On admission a 10 x 8 cm tumor in the left supraclavicular region was noted. The tumor had lobulated surface to bleed easily and fixed to the clavicle. Thoracic CT and MRI revealed a hypervascular tumor destroying the clavicle. Angiography showed keterogenous vascularity of the tumor vis the transverse and ascending cervical arteries. We carried out wide resection of the tumor with the clavicle and reconstructed with a left lattisimus dorsi flap. Since the tumor was composed of atypical fibroblasts and histiocytes. It was diagnosed as radiation induced malignant fibrous histiocytoma. After operation, inflammation of the flap and dyskinesia of the left upper extremity occurred, but were managed conservatively. There has been no sign of recurrence as of 2 years and 8 months after the operation. (author)

1996-12-01

47

Report of a Rare Case of Malignant Fibrous Histiocytoma of Mandible  

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Full Text Available Introduction: Malignent Fibrous Histiocytoma (MFH is the most frequent soft tissue sarcoma of adulthood. The most common sites affected by MFH are limbs, orbit, retroperitoneum, pelvis and knee. Oral cavity and mandible involvements are very rare. Case Report: A 35-year-old male was visited in the oral medicine department of Hamadan dental school with the chief complaint of pain and teeth mobility. The patient also had a history of paresthesia in lower lip for two monthes. In intraoral examination, there was a crater like, deep and disseminated ulcer in lower buccal and ligual gingiva of right mandibular teeth and exophitic lesion with smooth surface, and color similar to normal mucosa with 2×2×3 cm in diameter in buccal and lingual part of right lateral and central teeth extended to left second premolar was observed. Gingival resorption was observed in all adjascent teeth. There was radiolucency with irregular border in all part of lesion. MFH was confirmed by histopathological report.Conclusion: The most common complaint of patients with malignant fibrous histiocytoma is the growing mass that could be ulcerative or painful. Early diagnosis and referral is very important in prognosis and survival of the patients.

Fatemeh Ahmadi-Motamayel

48

Malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma of the penis. A case report  

International Nuclear Information System (INIS)

We report the case of a malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (MFH/UPS) of the penis in a 78-years-old-man who had undergone previous radical prostatectomy, external beam radiation therapy for prostatic adenocarcinoma. The mass was a 9-cm firm lesion at the base of the penis predominantly composed of malignant spindle cells arranged in sweeping fascicles and storiform pattern. The tumor cells stained for vimentin, ?-smooth muscle actin, S-100, and were negative for keratin, desmin, Melan A, prostate specific antigen (PSA). Despite total penectomy, he developed a local reccurence 4 months after surgery, and died from dissemination 6 months after surgery. This is the 8th case of penile MFH/UPS. (author)

2013-11-01

49

A case of radiation-induced pelvic malignant fibrous histiocytoma 8 years after radiotherapy for uterus cervical cancer  

International Nuclear Information System (INIS)

A case of postradiation malignant fibrous histiocytoma of the pelvis was reported. The patient is a 79-year-old woman. She was treated by radiation for cervical cancer of the uterus 8 years ago. The problem of second cancer will be more important in cancer treatment. (author)

1991-01-01

50

Pseudoaneurysm and ilio-caval fistula caused by malignant fibrous histiocytoma of the aorta - CT diagnosis and angiographic confirmation  

Energy Technology Data Exchange (ETDEWEB)

We report a case of a malignant fibrous histiocytoma (MFH) of the aortic bifurcation, which manifested as a pseudoaneurysm with the formation of an ilio-caval fistula, a complication about which, to our knowledge, nothing has been published previously. Spiral CT, catheter arteriography and venography were complementary in the diagnostic procedure. (orig.)

Szucs-Farkas, Zsolt; Toth, Judit; Peter, Mozes [Department of Radiology, University of Debrecen, Medical and Health Science Center, Debrecen (Hungary); Szollosi, Zoltan [Department of Pathology, University of Debrecen, Medical and Health Science Center, Debrecen (Hungary)

2002-02-01

51

Myxoid Type of Malignant Fibrous Histiocytoma of the Maxillary Sinus: A Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Myxofibrosarcoma was originally described as the myxoid variant of Malignant Fibrous Histiocytoma (MFH, a high-grade and aggressive sarcoma, which is very uncommon in the head and neck region, with about 100 cases reported up to now. MFH occurring in the maxillary sinus is so rare that only 23 cases have been reported. We hereby report a case of myxofibrosarcoma in the maxillary sinus. Case Report: The case was a 54-year-old male with symptoms of toothache in the right posterior maxillary teeth, a swelling adjacent to maxillary molar region and symptoms of chronic maxillary sinusitis. In clinical examination, the teeth were sensitive to percussion and palpation, but no caries and restoration was detected on his molar teeth. He was suffering from local pain and tenderness over his midface and mild fever, fatigue and some nonspecific vague pain. CT scan showed a mass lesion involving right nasal cavity, maxillary and ethmoidal sinuses. A low-grade malignancy arising from the right maxillary sinus was highly suspected. A surgery was done to remove the mass. The histological and immunohistochemical studies proved the diagnosis of myxoid variant of Malignant Fibrous Histiocytoma. Therefore radiotherapy and chemotherapy was started for the patient but six months later the symptoms returned and CT scan showed a right maxillary and ethmoidal mass that extended to base of the skull. Maxillectomy and ethmoidectomy were performed for the patient, but 2 months later he died because of the extension of the tumor, which confirmed the necessity of early diagnosis. Conclusion: Amplified radical surgery is the first choice of treatment. The second surgery has special value to the recurrent patients. Radiotherapy alone or chemotherapy alone is not effective to MFH of head and neck region

Amir Hossein Jafarian

2011-04-01

52

Radiologic evaluation of malignant histiocytoma  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma is a new malignant tumor entity of histiocytic origin which arises as a primary tumor of the bone as well as the soft tissue. Radiologic features of 12 cases of pathologically proven intra-and extraosseous malignant fibrous histiocytoma were analyzed. The results were as follows : 1. Seven cases were of soft tissue origin and 5 cases were of primary bone origin. 2. Seven were male and 5 were female: Eight cases were beyond 5th decades. 3. The clinical presentations of malignant fibrous histiocytoma of the soft tissue origin were a mass with rapid growth or high rate of local recurrence. The roentgen evidence of soft tissue density mass was demonstrated in 7 cases and scintigraphic evidence of cortical invasion was suggested in 2 cases. 4. Malignant fibrous histiocytoma arising from bones had ill defined moth-eaten osteolytic lesion with cortical destruction, periosteal reaction and soft tissue extension. 5. Among 12 cases, there were 2 cases of pulmonary metastases and 2 cases of osseous metastases. 6. In the presence of soft tissue mass with locally aggressive behavior and/or nonspecific roentgen features of malignant bone tumor, one should consider the possibility of malignant fibrous histiocytoma

1987-06-01

53

A radiation-induced malignant fibrous histiocytoma of the soft tissue after a carcinoma of the cervix  

International Nuclear Information System (INIS)

Presented are two cases of a radiation-induced malignant fibrous histiocytoma of the soft tissue following a carcinoma of the cervix. Case 1 is that of a 51-year-old female, who received postoperative radiotherapy of the pelvis, consisting of 60 Gy/25 fractions for 5 weeks. A large gluteal mass occurred 15 years later. Although this tumor responded to the radiotherapy and hyperthermia, the patient died of a recurrence 27 months later. Case 2 is that of a 62-year-old female, who underwent postoperative radiotherapy of 40 Gy/16 fractions for 4 weeks. A left gluteal tumor appeared 18 years later. After a resection of this tumor, she had repeated local recurrences. Three years after the operation, radio-hyperthermia was administered, and the patient has been doing well for a year. The histological diagnosis for both cases was a malignant fibrous histiocytoma of the ordinal type, which was considered to be a radiation-induced sarcoma. (author)

1991-01-01

54

Simultaneous occurrence of malignant fibrous histiocytoma and hepatocellular carcinoma in cirrhotic liver: A case report  

Directory of Open Access Journals (Sweden)

Full Text Available Primary hepatic malignant fibrous histiocytoma (MFH is rarely encountered. There have been no reports to date of hepatic MFH associated with liver cirrhosis. The presence of liver cirrhosis is considered an adjunctive feature favoring sarcomatoid hepatocellular carcinoma (HCC in the diagnosis of spindle cell tumors in liver. We describe here a 59-year-old man with liver cirrhosis due to hepatitis B virus infection 20 years ago. On abdominal computed tomography scanning, two distinct hepatic masses were identified in the background of cirrhosis, which had different radiological features from conventional HCC. He underwent segmentectomy for removal of the tumors. The pathological examination of surgically resected specimen revealed the large malignant spindle cell tumor and small conventional HCC. Additional tissue sampling and immunohistochemical stainings demonstrated that the spindle cell tumor was consistent with MFH. On the post-operative follow-up for 21 mo, a round mass showing similar radiological findings for the previous MFH was appeared on the surface of resection margin, suggesting the recurrence. Despite its rarity, hepatic MFH should be considered during differential diagnosis, even in cirrhotic patients, and extensive tissue sampling and immunohistochemical analyses are necessary in the diagnosis of hepatic spindle cell tumors.

Hee Sang Hwang

2011-01-01

55

Abdominal malignant fibrous histiocytoma infiltrating stomach with Chilaiditi's sign manifestation (a rare case report).  

Science.gov (United States)

The incidence and mortality rate of gastric cancer are decreasing within last 60 years. Approximately 85% of gastric cancer is carcinoma where as the rest 15% is lymphoma and sarcoma. Leiomyosarcoma is the most frequently encountered sarcoma in stomach and represents 1-3% gastric cancer. This tumor is frequently located in the anterior and posterior wall of gastric fundus accompanied by ulceration and bleeding. Malignant fibrous histiocytoma (MFH) is a soft tissue tumor with poor prognosis, rarely found in stomach. This tumor is most frequently originated from inner fascia or skeletal muscle (58-75%) and most frequently happen in the peritoneal cavity and abdomen (9-16 %). We reported a 45-year-old woman with abdominal MFH which infiltrated to the lesser curvature of stomach with Chilaiditi sign. Chilaiditi sign is a condition of intestine disposition (usually at the hepatic flexure of colon) which lies between liver and diagfragma, found in 0.1 ? 0.25% cases which is diagnosed by chest X Ray. This case is a very rare case. PMID:17684443

Nurdjanah, Siti; Bayupurnama, Putut; Maduseno, Sutanto; Ratnasari, Neneng

2007-01-01

56

Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report  

Energy Technology Data Exchange (ETDEWEB)

A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

Park, Hye Young; Seo, Jung Wook; Lee, Byung Hoon; Lee, Ji Young; Kim, Su Young; Cha, Soon Joo; Kim, Yong Hoon; Hwang, Yoon Joon; Kim, You Sung [Dept. of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang (Korea, Republic of)

2013-03-15

57

Manifestations and therapy of malignant fibrous histiocytomas in the head and neck area  

Energy Technology Data Exchange (ETDEWEB)

From 1982 through 1987, ten patients with malignant fibrous histiocytomas (MFH) in the head and neck area were treated at the ORL Department of the Central Hospital of Bremen. The primary tumor was situated in the region of the paranasal sinuses in six cases and in the parotid gland, the thyroid gland, the inferior maxilla, and the petrosal bone in one case, each. Nine patients were submitted to primary surgery. A postoperative irradiation was performed in four cases, and in four further cases this was done only when a recurrent tumor had been demonstrated. Three patients received a combined chemotherapeutical treatment. Eight patients died, the median survival time was 15 months. Besides local recurrences which occured frequently, remote metastases are the decisive factor for the further evolution of the disease. The lung was the most common site of metastatic spread. Only two patients with MFH of the parasanal sinuses are living now without recurrence after an observation time of 24 and 36 months, respectively. (orig.).

Schrader, B.; Schwartz, W.; Meier, C.R.; Friedrichsen, C.

1989-06-01

58

Malignant fibrous histiocytoma of the oral and maxillofacial region: a report of three cases  

Energy Technology Data Exchange (ETDEWEB)

Malignant fibrous histiocytoma (MFH) is a pleomorphic soft tissue sarcoma. Three cases of MFH were reported in our study. The first case involved in the right infratemporal fossa of a 32-year-old female was presented. MR imaging revealed a 5.0 x 3.3 cm soft tissue mass of inhomogeneous high signal intensity. The second caes was found in the right hard palate of a 66-year-old male. CT demonstrated bone destruction and MR imaging showed a 4 x 4 cm sized soft tissue mass of heterogeneous high signal intensity. The final case was found in the left masticator space of a 37-year-old male. The CT image showed a large mass with massive bone destruction of the left mandibular ramus, while the MRI displayed a soft tissue mass, 8 cm diameter. Our cases exhibited the general features of MFH. MRI is essential in the imaging of MFH, namely to depict tumor borders and demonstrate relationships with adjacent structures.

Han, Dong Hun; Heo, Min Suk; Lee, Sam Sun; Lee, Jin Koo; Choi, Soon Chul [Seoul National University College of Medicine, Seoul (Korea, Republic of); Choi, Jeong Hee [Chonnam National University College of Medicine, Kwangju (Korea, Republic of)

2003-12-15

59

Malignant fibrous histiocytoma of the oral and maxillofacial region: a report of three cases  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma (MFH) is a pleomorphic soft tissue sarcoma. Three cases of MFH were reported in our study. The first case involved in the right infratemporal fossa of a 32-year-old female was presented. MR imaging revealed a 5.0 x 3.3 cm soft tissue mass of inhomogeneous high signal intensity. The second caes was found in the right hard palate of a 66-year-old male. CT demonstrated bone destruction and MR imaging showed a 4 x 4 cm sized soft tissue mass of heterogeneous high signal intensity. The final case was found in the left masticator space of a 37-year-old male. The CT image showed a large mass with massive bone destruction of the left mandibular ramus, while the MRI displayed a soft tissue mass, 8 cm diameter. Our cases exhibited the general features of MFH. MRI is essential in the imaging of MFH, namely to depict tumor borders and demonstrate relationships with adjacent structures.

2003-12-01

60

Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report  

International Nuclear Information System (INIS)

A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

2013-03-01

 
 
 
 
61

[Prognostic significance of the clinical x-ray and morphological signs in malignant fibrous histiocytoma of bone].  

Science.gov (United States)

Forty-four cases of malignant fibrous histiocytoma were studied. A new index for patients' survival prognosis was developed and defined as a tumor growth rate. It is a ratio of maximal tumor size and duration of disease. Eight clinical x-ray and morphological factors of prognosis were identified: duration of disease, clinical manifestations, size and roentgenologic type of tumor, pattern of tumor contours, status of the cortical layer in bone lesions, tumor growth rate and morphologic grade of malignancy. A multifactorial analysis was carried out and data were presented in tables. Values of each parameter were calculated. PMID:2827391

Petrovichev, N N; Khmelev, O N; Annamukhamedov, A; Dvorova, E K

1987-01-01

62

Benign fibrous histiocytoma of the lumbar vertebrae  

International Nuclear Information System (INIS)

Benign fibrous histiocytoma is an extremely rare spinal tumor with ten reported cases in the literature. Benign fibrous histiocytoma constitutes a diagnostic challenge because it shares common clinical symptoms, radiological characteristics, and histological features with other benign lesions involving the spine. We present a case of benign fibrous histiocytoma of the lumbar spine and discuss its differential diagnosis and management. (orig.)

2009-02-01

63

Chemically induced transplantable malignant fibrous histiocytoma of the rat. Analyses with immunohistochemistry, immunoelectron microscopy and [3H]thymidine autoradiography  

International Nuclear Information System (INIS)

Malignant fibrous histiocytoma was produced in rats by injection of 9,10-dimethyl-1,2-benzanthracene into their knee joints. The original tumors consisted mainly of fibroblast-like cells and histiocyte-like cells, often intermixed with bizarre giant cells, and they frequently showed the storiform-pleomorphic pattern. By immunohistochemistry, anti-rat macrophage monoclonal antibodies, TRPM-3, RM-1, and Ki-M2R, and anti-rat leukocyte common antigen reacted to the histiocyte-like cells but not to the fibroblast-like cells. By the single cell cloning method, we established six tumor cell lines, none of which reacted with the anti-rat macrophage monoclonal antibodies, possessed any Fc receptors, or conducted immune phagocytosis and Latex particle phagocytosis. The ultrastructure of the cloned tumor cells resembled that of long-term cultured dermal fibroblasts. Collagen production by the tumor cells was demonstrated immunohistochemically with a monoclonal antibody for type I collagen. Inoculation of the cloned tumor cells into rats produced tumors with the histology of malignant fibrous histiocytoma and induced prominent macrophage infiltration. In the rat tumors produced by the inoculation of [3H]thymidine labeled cells, no reactivity of tumor cells with the anti-rat macrophage monoclonal antibodies was observed. Transplantation of the cultured rat tumor cells into nude mice produced tumors similar in histology to the original rat malignant fibrous histiocytoma. Tumor cells in nude mice induced marked macrophage infiltration as detected by immunohistochemistry with the anti-mouse macrophage monoclonal antibody F4/80. No differentiation of tumor cells into macrophages was detected, since no cells were stained with biotinylated anti-rat macrophage monoclonal antibody TRPM-3

1990-01-01

64

Chemically induced transplantable malignant fibrous histiocytoma of the rat. Analyses with immunohistochemistry, immunoelectron microscopy and (3H)thymidine autoradiography  

Energy Technology Data Exchange (ETDEWEB)

Malignant fibrous histiocytoma was produced in rats by injection of 9,10-dimethyl-1,2-benzanthracene into their knee joints. The original tumors consisted mainly of fibroblast-like cells and histiocyte-like cells, often intermixed with bizarre giant cells, and they frequently showed the storiform-pleomorphic pattern. By immunohistochemistry, anti-rat macrophage monoclonal antibodies, TRPM-3, RM-1, and Ki-M2R, and anti-rat leukocyte common antigen reacted to the histiocyte-like cells but not to the fibroblast-like cells. By the single cell cloning method, we established six tumor cell lines, none of which reacted with the anti-rat macrophage monoclonal antibodies, possessed any Fc receptors, or conducted immune phagocytosis and Latex particle phagocytosis. The ultrastructure of the cloned tumor cells resembled that of long-term cultured dermal fibroblasts. Collagen production by the tumor cells was demonstrated immunohistochemically with a monoclonal antibody for type I collagen. Inoculation of the cloned tumor cells into rats produced tumors with the histology of malignant fibrous histiocytoma and induced prominent macrophage infiltration. In the rat tumors produced by the inoculation of (3H)thymidine labeled cells, no reactivity of tumor cells with the anti-rat macrophage monoclonal antibodies was observed. Transplantation of the cultured rat tumor cells into nude mice produced tumors similar in histology to the original rat malignant fibrous histiocytoma. Tumor cells in nude mice induced marked macrophage infiltration as detected by immunohistochemistry with the anti-mouse macrophage monoclonal antibody F4/80. No differentiation of tumor cells into macrophages was detected, since no cells were stained with biotinylated anti-rat macrophage monoclonal antibody TRPM-3.

Kato, T.; Takeya, M.; Takagi, K.; Takahashi, K. (Kumamoto Univ. Medical School (Japan))

1990-05-01

65

Malignant Fibrous Histiocytoma of the Breast in Young Male Patient: A Case Report and a Review of the Literature  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Malignant Fibrous Histiocytoma (MFH) is a fairly common tumor in the deep soft tissues: the most frequent primary sites are the lower (49%) and upper (19%) limbs, but it has been reported even in the retroperitoneum and abdomen (16%), while localization in the breast is extremely rare (1-2). Breast cancer is rarely seen in males, accounts for approximately 1% of all breast cancer, and the breast sarcomas constitute less than 1% of breast tumors in both sexes. In the review of the literature, ...

Kocak Uzel, Esengul; Figen, Metin; Bek, Tuba Tulin; Inanc, Kubilay; Onder, Senem; Kizilkaya, Hazim Orhan

2013-01-01

66

Two Cases of Primary Malignant Fibrous Histiocytoma of the Liver: Immunohistochemical Expression of Ezrin and Its Relationship with Prognosis  

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Malignant fibrous histiocytoma (MFH) as soft tissue sarcoma would not be especially noteworthy, but primary hepatic MFH reports are extremely rare. Herein, we report ezrin expression in tumor tissues from two primary hepatic MFH cases with different prognoses. Cases 1 and 2 were both women, ages 45 and 70 years, respectively. Case 1 had an 11×10 cm liver tumor in segment (S) 3, and case 2 had two liver tumors, 12×8 cm in S5 and 10×7 cm in S8. Neither had any other systemic tumors. Cases 1 ...

Sugitani, Masahiko; Aramaki, Osamu; Kikuchi, Kentaro; Sheikh, Aleemuzzaman; Oinuma, Toshinori; Mamiya, Takao; Takayama, Tadatoshi; Nemoto, Norimichi

2009-01-01

67

A major response to trabectedin in metastatic malignant fibrous histiocytoma of the vertebra: a case report and review of the literature.  

Science.gov (United States)

Malignant fibrous histiocytoma is an aggressive tumor, the most common soft-tissue sarcoma of adult age. It is usually located in the extremities and retroperitoneum, and very rarely there is skeletal involvement. Surgery is the preferred treatment in early disease; in advanced disease, chemotherapy is the main therapeutic strategy. We present a 25-year-old female patient diagnosed with a vertebral mass in T5 with a severely compromised spinal cord. She underwent surgical decompression and the pathological findings were consistent with malignant fibrous histiocytoma. After several surgical treatments she had pulmonary progression and was therefore started on chemotherapy. She had a very poor response to most of the administered regimens until she initiated trabectedin 1 mg/m 2 every three weeks. She showed a significant improvement with a major response of the lung metastases. This report indicates that trabectedin is an active drug in advanced, previously treated metastatic malignant fibrous histiocytoma. PMID:23748828

Sereno, María; Merino, María; Aguayo, Cristina; Hernández, Susana; Gutiérrez-Gutiérrez, Gerardo; Zambrana Tévar, Francisco; López-Gómez, Miriam; Gómez Raposo, César; Casado-Sáenz, Enrique

2013-01-01

68

Malignant fibrous histiocytoma of the deep peri-articular tissue of the stifle in a dog : case report  

Directory of Open Access Journals (Sweden)

Full Text Available A Belgian shepherd dog aged 4 years and 9 months was presented with acute onset of non-weight bearing lameness and stifle effusion of the left hind limb, caused by the deep form of a malignant fibrous histiocytoma originating in the deep musculature and fascia surrounding the stifle joint. The tumour progressed rapidly in the tissues along the femoral diaphysis with marked periosteal new bone formation. Cytology of a stifle joint aspirate revealed numerous large polygonal neoplastic cells with considerable anisocytosis and anisokaryosis. These cells were present in clusters, with cytoplasmic projections between the cells, but occasionally also occurred singly. Several cells contained multiple cytoplasmic vacuoles and occasional giant cells were also encountered. Adequate tumour-free margins were not possible with radical limb amputation and the dog was euthanased. Macroscopically the tumour appeared as an extensive pale tan, firm mass with scattered small haemorrhages and foci of yellow discolouration. Histologically the tumour consisted of dense neoplastic expanses or multiple nodules, composed of spindle-shaped fibroblastic cells, polygonal histiocytic cells or cell clusters and scattered giant cells with 2-3 nuclei. The polygonal neoplastic cells were frequently present around and invading lymphatics and blood vessels, causing neoplastic emboli. This is the 1st report of the clinical behaviour, radiography and cytology of the deep form of malignant fibrous histiocytoma in the dog.

M.J. Booth

2012-07-01

69

Benign Fibrous Histiocytoma of the Maxillary Sinus  

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Fibrous Histiocytoma is an uncommon neoplasm of the Head and Neck region and quite rare in the paranasal sinuses. We are reporting a case of Benign Fibrous Histiocytoma in the Maxillary sinus from the Department of Otorhinolaryngology of Bolani Hospital, Bolani with a description of clinical and histological features of the neoplasm.

Singh, Mangal

1998-01-01

70

Accumulation of MRI contrast agents in malignant fibrous histiocytoma for gadolinium neutron capture therapy  

International Nuclear Information System (INIS)

Neutron-capture therapy with gadolinium (Gd-NCT) has therapeutic potential, especially that gadolinium is generally used as a contrast medium in magnetic resonance imaging (MRI). The accumulation of gadolinium in a human sarcoma cell line, malignant fibrosis histiocytoma (MFH) Nara-H, was visualized by the MRI system. The commercially available MRI contrast medium Gd-DTPA (Magnevist, dimeglumine gadopentetate aqueous solution) and the biodegradable and highly gadopentetic acid (Gd-DTPA)-loaded chitosan nanoparticles (Gd-nanoCPs) were prepared as MRI contrast agents. The MFH cells were cultured and collected into three falcon tubes that were set into the 3-tesra MRI system to acquire signal intensities from each pellet by the spin echo method, and the longitudinal relaxation time (T1) was calculated. The amount of Gd in the sample was measured by inductively coupled plasma atomic emission spectrography (ICP-AES). The accumulation of gadolinium in cells treated with Gd-nanoCPs was larger than that in cells treated with Gd-DTPA. In contrast, and compared with the control, Gd-DTPA was more effective than Gd-nanoCPs in reducing T1, suggesting that the larger accumulation exerted the adverse effect of lowering the enhancement of MRI. Further studies are warranted to gain insight into the therapeutic potential of Gd-NCT.

2009-07-01

71

Accumulation of MRI contrast agents in malignant fibrous histiocytoma for gadolinium neutron capture therapy  

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Neutron-capture therapy with gadolinium (Gd-NCT) has therapeutic potential, especially that gadolinium is generally used as a contrast medium in magnetic resonance imaging (MRI). The accumulation of gadolinium in a human sarcoma cell line, malignant fibrosis histiocytoma (MFH) Nara-H, was visualized by the MRI system. The commercially available MRI contrast medium Gd-DTPA (Magnevist, dimeglumine gadopentetate aqueous solution) and the biodegradable and highly gadopentetic acid (Gd-DTPA)-loaded chitosan nanoparticles (Gd-nanoCPs) were prepared as MRI contrast agents. The MFH cells were cultured and collected into three falcon tubes that were set into the 3-tesra MRI system to acquire signal intensities from each pellet by the spin echo method, and the longitudinal relaxation time (T1) was calculated. The amount of Gd in the sample was measured by inductively coupled plasma atomic emission spectrography (ICP-AES). The accumulation of gadolinium in cells treated with Gd-nanoCPs was larger than that in cells treated with Gd-DTPA. In contrast, and compared with the control, Gd-DTPA was more effective than Gd-nanoCPs in reducing T1, suggesting that the larger accumulation exerted the adverse effect of lowering the enhancement of MRI. Further studies are warranted to gain insight into the therapeutic potential of Gd-NCT.

Fujimoto, T. [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan)], E-mail: fujitaku@hp.pref.hyogo.jp; Ichikawa, H. [Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586 (Japan); Akisue, T. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Fujita, I. [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan); Kishimoto, K.; Hara, H. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Imabori, M. [Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-0021 (Japan); Kawamitsu, H. [Department of Radiology, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Sharma, P.; Brown, S.C.; Moudgil, B.M. [Particle Engineering Research Center, University of Florida, Gainesville, FL32611 (United States); Fujii, M. [Department of Radiology, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Yamamoto, T. [Department of Orthopaedic Surgery, Kagawa University, Kagawa 761-0793 (Japan); Kurosaka, M. [Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Fukumori, Y. [Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586 (Japan)

2009-07-15

72

Accumulation of MRI contrast agents in malignant fibrous histiocytoma for gadolinium neutron capture therapy.  

Science.gov (United States)

Neutron-capture therapy with gadolinium (Gd-NCT) has therapeutic potential, especially that gadolinium is generally used as a contrast medium in magnetic resonance imaging (MRI). The accumulation of gadolinium in a human sarcoma cell line, malignant fibrosis histiocytoma (MFH) Nara-H, was visualized by the MRI system. The commercially available MRI contrast medium Gd-DTPA (Magnevist, dimeglumine gadopentetate aqueous solution) and the biodegradable and highly gadopentetic acid (Gd-DTPA)-loaded chitosan nanoparticles (Gd-nanoCPs) were prepared as MRI contrast agents. The MFH cells were cultured and collected into three falcon tubes that were set into the 3-tesra MRI system to acquire signal intensities from each pellet by the spin echo method, and the longitudinal relaxation time (T1) was calculated. The amount of Gd in the sample was measured by inductively coupled plasma atomic emission spectrography (ICP-AES). The accumulation of gadolinium in cells treated with Gd-nanoCPs was larger than that in cells treated with Gd-DTPA. In contrast, and compared with the control, Gd-DTPA was more effective than Gd-nanoCPs in reducing T1, suggesting that the larger accumulation exerted the adverse effect of lowering the enhancement of MRI. Further studies are warranted to gain insight into the therapeutic potential of Gd-NCT. PMID:19386506

Fujimoto, T; Ichikawa, H; Akisue, T; Fujita, I; Kishimoto, K; Hara, H; Imabori, M; Kawamitsu, H; Sharma, P; Brown, S C; Moudgil, B M; Fujii, M; Yamamoto, T; Kurosaka, M; Fukumori, Y

2009-07-01

73

Mast Cells Inhibit CD8+ T Cell-Mediated Rejection of a Malignant Fibrous Histiocytoma-Like Tumor: Involvement of Fas-Fas Ligand Axis  

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Problem statement: Mast cells develop from bone marrow-derived progenitor cells and are distributed in the skin or mucosa where they play proinflammatory roles in the first line of defense. Since some tumors in humans and experimental animals exhibited infiltration of increased mast cells, we investigated the contribution of mast cells to the override of tumor rejection. Approach: MRL/N-1 cells are malignant fibrous histiocytoma-like cells established from the spleen of a Fas li...

Hiroshi Furukawa; Hiroshi Kitazawa; Izumi Kaneko; Koichi Koichi; Shigeto Tohma; Masato Nose; Masao Ono

2009-01-01

74

Deletion mapping of chromosome 8p in colorectal carcinoma and dysplasia arising in ulcerative colitis, prostatic carcinoma, and malignant fibrous histiocytomas.  

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Short tandem repeat polymorphism markers on the short arm of chromosome 8 were used to search for loss of heterozygosity (LOH) in colorectal carcinoma and dysplasia complicating ulcerative colitis, in prostatic carcinoma, and in malignant fibrous histiocytoma (MFH). Fifty percent of prostatic carcinomas (13/26), 44% of carcinomas or dysplasias arising in ulcerative colitis (7/16), and 30% (4/12) of MFH cases showed LOH for markers on 8p. Detailed mapping demonstrated variability in the size o...

1994-01-01

75

Myxoid Variant of So-called Angiomatoid "Malignant Fibrous Histiocytoma": Clinicopathologic Characterization in a Series of 21 Cases.  

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Angiomatoid "malignant fibrous histiocytoma" (AMFH) is a tumor of intermediate malignancy and undefined lineage, mostly arising in the extremities of young patients. Examples with a prominent myxoid matrix are very uncommon. Twenty-one cases of myxoid AMFH (among a total of 414) identified in consult files are described, including clinicopathologic features, fluorescence in situ hybridization analysis in a subset of cases, and follow-up. Thirteen patients were female and 8 male, ranging in age from 2 to 51 y (median 17 y). These circumscribed tumors arose in subcutaneous or deep somatic soft tissue, with a median size of 2.5 cm (range, 1 to 8 cm), being located in the extremities (14/21), trunk (4/21), and upper limb girdle (3/21). Characteristic features included a fibrous pseudocapsule (20/21), peritumoral lymphoplasmacytic infiltrates (20/21), blood-filled cystic spaces (17/21), and prominent myxoid morphology comprising 60% to 100% of the tumor surface area examined. Histiocytoid or spindled tumor cells exhibited vesicular nuclei, inconspicuous nucleoli, palely eosinophilic cytoplasm, and multinodular growth without necrosis. Mucin pools and scattered multinucleate giant cells were observed in a subset of cases. Mild to moderate atypia was observed in 4 cases; 1 tumor showed a pseudochondroid matrix. Immunohistochemically, 14/21 cases expressed desmin, 12/21 expressed EMA, and 4/7 exhibited EWSR1 rearrangement. Follow-up, available for 11 patients (median, 43 mo), revealed that 3 developed local recurrence after 2, 7, and 48 months, respectively. All patients were alive without metastases. AMFH may present with prominent myxoid features making diagnosis difficult and causing possible confusion with other myxoid tumors including low-grade fibromyxoid sarcoma, extraskeletal myxoid chondrosarcoma, and myxoid liposarcoma. PMID:24503754

Schaefer, Inga-Marie; Fletcher, Christopher D M

2014-06-01

76

Atypical Cutaneous Fibrous Histiocytoma: An Unusual and Misleading Variant of Fibrous Histiocytoma  

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Atypical fibrous histiocytoma is a distinctive variant of cutaneous fibrous histiocytoma, which is often mistaken histologically for sarcoma and which have a tendency to recur locally and a capacity to metastasize, although very rarely. We report a new case of atypical cutaneous fibrous histiocytoma in a 31-year-old man who presented with a recurrent polypoid nodule on the abdominal wall. The diagnosis was made on the basis of morphological and immunohistochemical findings. We discuss through...

Ben Abdelkrim, Soumaya; Belajouza, Colondane; Jomaa, Wafa; Beizig, Nadia; Ben Said, Zeineb; Mokni, Moncef; Nouira, Rafia; Sriha, Badreddine

2011-01-01

77

Fibro-histiocitoma maligno da pálpebra: relato de caso Malignant fibrous histiocytoma of the eyelid: case report  

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Os fibro-histiocitomas representam 1% das massas orbitárias e podem ser histologicamente classificados em benignos, localmente agressivos e malignos - os últimos representando aproximadamente 11% do total. Nesse estudo, os autores descrevem um caso raro de fibro-histiocitoma maligno de pálpebra, ressaltando as características clínicas e histopatológicas desta neoplasia.Fibrous histiocytomas represent 1% of all orbital masses and may be classified into benign, locally aggressive and ...

2009-01-01

78

Transcutaneous application of CO2 enhances the antitumor effect of radiation therapy in human malignant fibrous histiocytoma.  

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Sarcomas are relatively resistant because of hypoxia. We previously demonstrated that the transcutaneous CO2 therapy reduced hypoxic conditions in human malignant fibrous histiocytoma (MFH). Therefore, we hypothesized that transcutaneous CO2 therapy could enhance the antitumor effect of radiation therapy in human MFH. Our purpose was to evaluate the effects of transcutaneous CO2 therapy on the antitumor efficacy of X-ray irradiation using MFH. First, in an in vitro study, we assessed apoptotic activity and reactive oxygen species (ROS) production using flow cytometric and immunoblot analysis at 24 h after X-ray irradiation under three different oxygen conditions (normoxic, reoxygenated and hypoxic). In addition, in the in vivo study, 24 male athymic BALB/c nude mice with MFH tumors that were inoculated in the dorsal subcutaneous area were randomized into four groups: control, CO2, X-ray irradiation and combination (CO2 and X-ray irradiation). Treatments were performed twice weekly for 2 weeks, four times in total. Tumor volume was calculated. All tumors were excised and apoptotic activity, ROS production, related proteins and HIF-1? expression were assessed using flow cytometric and immunoblot analysis. The in vitro study revealed that X-ray irradiation induced increased apoptosis and ROS production in MFH cells under normoxic and reoxygenated conditions relative to hypoxic conditions (Pincreased with decreasing HIF-1? expression relative to the control, CO2 and X-ray groups. The transcutaneous CO2 system enhanced the antitumor action of X-ray irradiation and could be a novel therapeutic tool for overcoming radio-resistance in human malignancies. PMID:24889546

Onishi, Yasuo; Akisue, Toshihiro; Kawamoto, Teruya; Ueha, Takeshi; Hara, Hitomi; Toda, Mitsunori; Harada, Risa; Minoda, Masaya; Morishita, Masayuki; Sasaki, Ryohei; Nishida, Kotaro; Kuroda, Ryosuke; Kurosaka, Masahiro

2014-08-01

79

Transcutaneous Application of Carbon Dioxide (CO2) Induces Mitochondrial Apoptosis in Human Malignant Fibrous Histiocytoma In Vivo  

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Mitochondria play an essential role in cellular energy metabolism and apoptosis. Previous studies have demonstrated that decreased mitochondrial biogenesis is associated with cancer progression. In mitochondrial biogenesis, peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1?) regulates the activities of multiple nuclear receptors and transcription factors involved in mitochondrial proliferation. Previously, we showed that overexpression of PGC-1? leads to mitochondrial proliferation and induces apoptosis in human malignant fibrous histiocytoma (MFH) cells in vitro. We also demonstrated that transcutaneous application of carbon dioxide (CO2) to rat skeletal muscle induces PGC-1? expression and causes an increase in mitochondrial proliferation. In this study, we utilized a murine model of human MFH to determine the effect of transcutaneous CO2 exposure on PGC-1? expression, mitochondrial proliferation and cellular apoptosis. PGC-1? expression was evaluated by quantitative real-time PCR, while mitochondrial proliferation was assessed by immunofluorescence staining and the relative copy number of mitochondrial DNA (mtDNA) was assessed by real-time PCR. Immunofluorescence staining and DNA fragmentation assays were used to examine mitochondrial apoptosis. We also evaluated the expression of mitochondrial apoptosis related proteins, such as caspases, cytochorome c and Bax, by immunoblot analysis. We show that transcutaneous application of CO2 induces PGC-1? expression, and increases mitochondrial proliferation and apoptosis of tumor cells, significantly reducing tumor volume. Proteins involved in the mitochondrial apoptotic cascade, including caspase 3 and caspase 9, were elevated in CO2 treated tumors compared to control. We also observed an enrichment of cytochrome c in the cytoplasmic fraction and Bax protein in the mitochondrial fraction of CO2 treated tumors, highlighting the involvement of mitochondria in apoptosis. These data indicate that transcutaneous application of CO2 may represent a novel therapeutic tool in the treatment of human MFH.

Onishi, Yasuo; Kawamoto, Teruya; Ueha, Takeshi; Kishimoto, Kenta; Hara, Hitomi; Fukase, Naomasa; Toda, Mitsunori; Harada, Risa; Minoda, Masaya; Sakai, Yoshitada; Miwa, Masahiko; Kurosaka, Masahiro; Akisue, Toshihiro

2012-01-01

80

Atypical cutaneous fibrous histiocytoma: an unusual and misleading variant of fibrous histiocytoma.  

Science.gov (United States)

Atypical fibrous histiocytoma is a distinctive variant of cutaneous fibrous histiocytoma, which is often mistaken histologically for sarcoma and which have a tendency to recur locally and a capacity to metastasize, although very rarely. We report a new case of atypical cutaneous fibrous histiocytoma in a 31-year-old man who presented with a recurrent polypoid nodule on the abdominal wall. The diagnosis was made on the basis of morphological and immunohistochemical findings. We discuss through this case and a review of the literature pathological and evolutive features and diagnostic difficulties of this entity. PMID:22937387

Ben Abdelkrim, Soumaya; Belajouza, Colondane; Jomaa, Wafa; Beizig, Nadia; Ben Said, Zeineb; Mokni, Moncef; Nouira, Rafia; Sriha, Badreddine

2011-01-01

 
 
 
 
81

Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report.  

Science.gov (United States)

Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses. The patient had no other primary malignant neoplasm, thus excluding a metastatic lesion. Gross examination revealed a thickened right pulmonary artery and a necrotic and hemorrhagic tumor, filling and occluding the vascular lumen. The mass extended distally, within the pulmonary vasculature of the right lung. Microscopically, an intravascular undifferentiated tumor was identified. The tumor cells showed expression for vascular markers VEGFR, VEGFR3, PDGFRa, FGF, Ulex europaeus, FVIII, FLI-1, CD31 and CD34; p53 was overexpressed and Ki67 proliferative rate was increased. Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome. PMID:23134683

Bohn, Olga L; de León, Eric Acosta-Ponce; Lezama, Oscar; Rios-Luna, Nina P; Sánchez-Sosa, Sergio; Llombart-Bosch, Antonio

2012-01-01

82

Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report  

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Full Text Available Abstract Primary sarcomas of the major blood vessels can be classified based on location in relationship to the wall or by histologic type. Angiosarcomas are malignant neoplasms that arise from the endothelial lining of the blood vessels; those arising in the intimal compartment of pulmonary artery are rare. We report a case of pulmonary artery angiosarcoma in a 36-year old female with pulmonary masses. The patient had no other primary malignant neoplasm, thus excluding a metastatic lesion. Gross examination revealed a thickened right pulmonary artery and a necrotic and hemorrhagic tumor, filling and occluding the vascular lumen. The mass extended distally, within the pulmonary vasculature of the right lung. Microscopically, an intravascular undifferentiated tumor was identified. The tumor cells showed expression for vascular markers VEGFR, VEGFR3, PDGFRa, FGF, Ulex europaeus, FVIII, FLI-1, CD31 and CD34; p53 was overexpressed and Ki67 proliferative rate was increased. Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome. Virtual slide The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2315906377648045.

Bohn Olga L

2012-11-01

83

Benign fibrous histiocytoma of a metacarpal bone  

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Benign fibrous histiocytoma (BFH) is a rare skeletal tumour. Its occurrence in the metacarpal bones is even rarer. The management in this location can be challenging, involving tumour resection and metacarpal reconstruction. The authors present a case of BFH involving the second metacarpal bone.

Onovo, Obiora Daniel; Eyesan, Samuel Uwale; Abdulkareem, Fatima Biade

2011-01-01

84

Benign fibrous histiocytoma of a metacarpal bone.  

Science.gov (United States)

Benign fibrous histiocytoma (BFH) is a rare skeletal tumour. Its occurrence in the metacarpal bones is even rarer. The management in this location can be challenging, involving tumour resection and metacarpal reconstruction. The authors present a case of BFH involving the second metacarpal bone. PMID:22715263

Onovo, Obiora Daniel; Eyesan, Samuel Uwale; Abdulkareem, Fatima Biade

2011-01-01

85

Benign Fibrous Histiocytoma of the Maxillary Sinus  

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Fobrous Histiogytoma is an uncommon neoplasm of the Head and Neck region and quite rare in the paranasal sinuses. We are reporting a case of Benign Fibrous Histiocytoma in the Maxillary sinus from the Department of Otorhinolaryngology of Bolani Hospital, Bolani with a description of clinical and histological features of the neoplasm.

Majurrider, Aloke Bose

1999-01-01

86

Benign fibrous histiocytoma of the maxillary sinus.  

Science.gov (United States)

Fobrous Histiogytoma is an uncommon neoplasm of the Head and Neck region and quite rare in the paranasal sinuses. We are reporting a case of Benign Fibrous Histiocytoma in the Maxillary sinus from the Department of Otorhinolaryngology of Bolani Hospital, Bolani with a description of clinical and histological features of the neoplasm. PMID:23119482

Majurrider, A B

1999-01-01

87

Calculation of probability of causation for non-specified radiogenic cancer cases. Etiologic judgement of a malignant fibrous histiocytoma developed at the elbow of a plutonium contaminated worker  

International Nuclear Information System (INIS)

A criterion for the compensation of patients with radiogenic cancer has been formulated for five specified cancers. A method of calculation of the probability of causation (PC) of non-specified cancers was applied to a case of malignant fibrous histiocytoma developed at the elbow of a plutonium contaminated worker. According to the histologic structure of the tumour, there were three possible target cells, and their doses were evaluated with the available data of urine plutonium. Then PC was calculated with excess relative risk coefficient indirectly deduced from related animal experiment. The result showed that the obtained PC varied greatly with the supposed target cells. If the target cells were periosteum cells, the PC might exceed 50 percent, but that might not be true, and the tumour might come from fibroblasts, and then PC might be less than 1 percent

1995-02-01

88

Aneurysmal and haemangiopericytoma-like fibrous histiocytoma.  

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AIM: To describe the clinicopathological features of 33 aneurysmal fibrous histiocytomas (AFH), including five cases with a haemangiopericytoma-like pattern. METHODS: Thirty three cases of AFH were studied by using routine histology and immunohistochemistry for factor XIIIa, the "cell activity marker" E9 (anti-metallothionein), NK1C3 (CD57), smooth muscle actin (SMA), factor VIII, ulex europaeus agglutinin, JC70A (CD31), and QBEND10 (CD34). The time dependent variation in histopatholo...

Zelger, B. W.; Zelger, B. G.; Steiner, H.; Ofner, D.

1996-01-01

89

Mast Cells Inhibit CD8+ T Cell-Mediated Rejection of a Malignant Fibrous Histiocytoma-Like Tumor: Involvement of Fas-Fas Ligand Axis  

Directory of Open Access Journals (Sweden)

Full Text Available Problem statement: Mast cells develop from bone marrow-derived progenitor cells and are distributed in the skin or mucosa where they play proinflammatory roles in the first line of defense. Since some tumors in humans and experimental animals exhibited infiltration of increased mast cells, we investigated the contribution of mast cells to the override of tumor rejection. Approach: MRL/N-1 cells are malignant fibrous histiocytoma-like cells established from the spleen of a Fas ligand (FasL-deficient MRL/Mp-FasLgld/gld (MRL/gld mouse and are implantable in Fas-deficient MRL/Mp-Faslpr/lpr (MRL/lpr mice. MRL/N-1 cells were implanted in MRL/gld, MRL/lpr and MRL/+mice after antibody treatments or with mast cells or macrophages and the tumor growth was observed. Results: MRL/N-1 cells were rejected by Fas-intact syngeneic MRL/+ mice in CD8+ T cell-mediated manner. This rejection was inhibited by the co-implanted mast cells. MRL/N-1 cells transfected with FasL were rejected by MRL/+ and MRL/gld mice. Conclusion: Mast cells abrogate the rejection of MRL/N-1 tumor cells and that this tumor rejection is mediated by CD8+ T cells and dependent on host Fas-FasL axis.

Shigeto Tohma

2009-01-01

90

Benign fibrous histiocytoma of the retroperitoneum. Benignes Histiozytom des Retroperitoneums  

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A case of benign fibrous histiocytoma of the retroperitoneum accidentally found on ultrasound in a fifty-six year old woman is reported. Diagnosis and differential diagnosis in special consideration or radiological methods are discussed. (orig.)

Feix, I. (Abteilung fuer Radiologie und Nuklearmedizin, Krankenhaus am Urban, Berlin (Germany))

1993-05-01

91

Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluorescence in situ hybridization (M-FISH, Urovysion™ FISH, and comparative genomic hybridization (CGH for the characterization of chromosomal aberrations. FU-MFH-2 cells were spindle or polygonal in shape with oval nuclei, and were successfully maintained in vitro for over 80 passages. The histological features of heterotransplanted tumors in severe combined immunodeficiency mice were essentially the same as those of the original tumor. Cytogenetic and M-FISH analyses displayed a hypotriploid karyotype with numerous structural aberrations. Urovysion™ FISH revealed a homozygous deletion of the p16INK4A locus on chromosome band 9p21. CGH analysis showed a high-level amplification of 9q31-q34, gains of 1p12-p34.3, 2p21, 2q11.2-q21, 3p, 4p, 6q22-qter, 8p11.2, 8q11.2-q21.1, 9q21-qter, 11q13, 12q24, 15q21-qter, 16p13, 17, 20, and X, and losses of 1q43-qter, 4q32-qter, 5q14-q23, 7q32-qter, 8p21-pter, 8q23, 9p21-pter, 10p11.2-p13, and 10q11.2-q22. Conclusion The FU-MFH-2 cell line will be a particularly useful model for studying molecular pathogenesis of human pleomorphic MFH.

Isayama Teruto

2010-11-01

92

Case report 359: Gigantic benign fibrous histiocytoma (nonossifying fibroma)  

International Nuclear Information System (INIS)

In summary, a fascinating case is presented of an enormous 'blow-out' lesion in the left half of the mandible in a 17-year-old boy. The histological diagnosis was benign fibrous histiocytoma or non-ossifying fibroma. An extensive differential diagnosis was presented by the authors and although benign fibrous histiocytoma was their final diagnosis, they could not exclude an example of the rarely encountered entity called the Jaffe-Campanacci syndrome. This syndrome consists of multiple non-ossifying fibromas of the mandible, cafe-au-lait spots, various endocrine disorders, mental retardation, occular anomalies and cardiovascular malformations. (orig./SHA)

1986-01-01

93

Fibrous histiocytoma (fibroxanthoma) of a cervical vertebra  

International Nuclear Information System (INIS)

A patient with a benign appearing intraoseous fibrous lesion of the cervical verebra is presented. The lesion had the histologic features of nonossifying fibroma (metyphyseal fibrous defect).Because of its atypical location and unusual radiologic appearance, the lesion was diagnosed as a fibrous histocytoma, a tumor whose histology is similar to non-ossifying fibroma. The literature was reviewed for similar cases located outside the metaphysis of the long bones. Support is given for designating such lesions as fibrous histocytomas rather than non-ossifying fibromas. (orig.)

1980-01-01

94

Subcutaneous benign fibrous histiocytoma of the cheek. Case report and review of the literature  

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Fibrous histiocytoma is a benign tumour composed of a mixture of fibroblastic and histiocytic cells. Based on the location of this tumour, fibrous histiocytoma are usually divided into cutaneous types and those involving deep tissues. These lesions most often arise on the skin, but may rarely occur in soft deep tissues. The diagnosis of fibrous histiocytoma may be clinically difficult when the lesion is located in the deep tissues, and is frequently confirmed after local excision. The most im...

Skoulakis, Ce; Papadakis, Ce; Datseris, Ge; Drivas, Ei; Kyrmizakis, DE; Bizakis, Jg

2007-01-01

95

Benign fibrous histiocytoma arising from the right shoulder: Is immunohistochemical staining always required for a definitive diagnosis?  

Science.gov (United States)

INTRODUCTION Fibrous histiocytomas are divided into two subgroups: malignant and benign fibrous histiocytomas (BFHs). BFH is one of the most common tumors of the superficial and deep soft tissues; it is commonly found on the skin and presents as a slow-growing solitary nodule made up of a mixture of fibroblastic and histiocytic cells. PRESENTATION OF CASE In this study, we present the case of a 45-year-old female who was histopathologically diagnosed with dermatofibrosarcoma protuberans (DFSP) and received radiotherapy, but whose diagnosis was changed to BFH based on subsequent immunohistochemical analyses. DISCUSSION BFH is a mesenchymal soft-tissue tumor with fibroblastic and histiocytic differentiation. Differential diagnosis for BFH found in deeper tissues includes other aggressive fibrohistiocytic lesions, such as DFSP and malignant fibrous histiocytoma. Differentiating among these tumors is crucial in selecting the correct surgical strategy and patient management in the postoperative period. In most cases, the pleomorphism and atypical mitotic activity seen histopathologically are sufficient for the differentiation between benign and malignant tumors. Immunohistochemical staining methods should be used in cases that are difficult to diagnose. The treatment of choice for BFH is wide resection of the tumor, which results in an excellent prognosis and low recurrence rate. In agreement with cases reported in the literature, our case confirms that wide excision is adequate to prevent the recurrence of the tumor. CONCLUSION Although benign fibrous histiocytomas is rare, it must be considered in the differential diagnosis of tumors arising from the soft-tissue.

Akbulut, Sami; Arikanoglu, Zulfu; Basbug, Murat

2012-01-01

96

Angiomatoid fibrous histiocytoma: first report of primary pulmonary origin.  

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Angiomatoid fibrous histiocytoma is an uncommon soft tissue tumor most frequently affecting the deep dermis and subcutis of the extremities in children and young adults. We report the first case presenting as a primary pulmonary tumor in a 46-year-old man. Histologically, the tumor was composed of multiple cellular nodules surrounded by a fibrous pseudocapsule and peritumoral lymphoplasmacytic infiltrates. The nodules were composed of histiocytoid cells with a diffuse, whorled, or vague storiform pattern, with the intervening areas densely packed with plasma cells and lymphocytes. The tumor cells were immunoreactive for epithelial membrane antigen, and focally desmin, CD68, and CD163. Fluorescence in-situ hybridization revealed EWS gene translocation, which was further confirmed on polymerase chain reaction to result from EWS/ATF1 gene fusion. It is important to recognize that angiomatoid fibrous histiocytoma can occur in the lung because its histologic features are rather nondescript and thus can be mistaken for other tumors such as meningioma, inflammatory myofibroblastic tumor, and follicular dendritic cell sarcoma. PMID:19654501

Ren, Li; Guo, Shuang-Ping; Zhou, Xiao-Ge; Chan, John K C

2009-10-01

97

Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum.  

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Angiomatoid fibrous histiocytoma, a fibrohistiocytic tumour of intermediate malignancy that usually presents on extremities of young patients, has a broader clinical/histological spectrum than is widely appreciated. We summarise our experience with an emphasis on unusual features. Twenty-seven cases were analysed for clinical and histological features, including immunohistochemistry and FISH for rearrangements of EWSR1 or FUS. Five (19%) occurred in patients >40 years old, and ten (37%) occurred outside the extremities. Three that occurred in patients >40 years old arose in atypical locations. Evaluation for classical histological features (lymphocytic cuff, fibrous pseudocapsule, pseudovascular spaces, haemorrhage, haemosiderin, and histiocytoid morphology) showed that all had two or more classical features. Unusual features were noted in many cases. Ten (37%) displayed significant areas of sclerosis; three of these ten had areas with a perineurioma-like pattern. Nine displayed at least moderate pleomorphism, with two exhibiting striking pleomorphism. Eight had eosinophils in the stroma, one with numerous eosinophils. One had a reticulated pattern of cells in a myxoid stroma. Mitotic rates were low [average 0.67/10 high power fields (HPFs)]. Three had atypical mitotic figures. Thirteen of 20 (65%) were CD68 positive, 11 of 17 (65%) were EMA positive, and 10 of 18 (56%) were desmin positive. Thirteen of 16 (81%) had a rearrangement of EWSR1; none had a FUS rearrangement.This series expands the spectrum of angiomatoid fibrous histiocytoma. PMID:24614712

Bohman, Summer L; Goldblum, John R; Rubin, Brian P; Tanas, Munir R; Billings, Steven D

2014-04-01

98

Benign fibrous histiocytoma presenting as anal canal polyp: first case report.  

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Nonepithelial and nonmelanocytic anal neoplasms are uncommon. The majority are mesenchymal tumors, most of which are malignant sarcomas, particularly leiomyosarcomas and gastrointestinal stromal tumors. Benign mesenchymal anal neoplasms are even rarer. The most common reported cases were anal leiomyomas, granular cell tumors, fibroadenomas, and xanthogranulomas. Benign fibrous histiocytomas (BFHs) or dermatofibromas are common mesenchymal cutaneous tumors that occur in different sites and at any age. Review of the literature did not show previous reports of BFH arising in the anal canal region. We report the first case of a solitary BFH, an unexpected occurrence of a common tumor type presenting as a polyp in an unusual site such as the anus. This rare occurrence can present diagnostic challenges for the surgeons and pathologists. Clinically, it can be confused with the usual anal tags, fibroepithelial polyps, or hemorrhoids. Benign fibrous histiocytoma is a neoplasm with a potential of local recurrence and, therefore, carries certain clinical implications for the patients' management and follow-up when compared with the common nonneoplastic causes of anal polyps such as the anal tags of anal fissures, hemorrhoids, or fibroepithelial papilla. Histologically, it should be differentiated from other histiocytic lesions. This can be resolved by the application of certain histologic features with the appropriate immunohistochemical markers taken within the correct clinical context. PMID:22999485

AbdullGaffar, Badr; Abdulrahim, Manal; Ghazi, Esaaf

2013-10-01

99

Malignant fibrous histiozytoma  

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Malignant fibrous histiozytoma (MHF) is a pleomorphic sarcoma of ubiquituous origin. The clinical and radiological features of the tumor are illustrated by 23 patients with MFH of soft tissue and 4 MFH of bone. On conventional radiography MFH appears as a soft tissue tumor, sometimes with bone involvement; on sonography it is usually non-homogeneous and hypoechogenic with areas of necrosis. On CT the masses are homogeneous or inhomogeneous (10-60 HU.) containing areas of decreased density. Contrast enhancement was about 10-20 HU. Angiographically the tumor appears as hypo- or hypervascular with pathologic vessels. The morphology of MFH in diagnostic imaging including magnetic resonance tomography is discussed with the relevant literature. (orig.)

1988-01-01

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Piezoelectric-assisted removal of a benign fibrous histiocytoma of the mandible: An innovative technique for prevention of dentoalveolar nerve injury  

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Abstract In this article, we present our experience with a piezoelectric-assisted surgical device by resection of a benign fibrous histiocytoma of the mandible. A 41 year-old male was admitted to our hospital because of slowly progressive right buccal swelling. After further radiographic diagnosis surgical removal of the yellowish-white mass was performed. Histologic analysis showed proliferating histiocytic cells with foamy, granular cytoplasm and no signs of malignancy. The...

2011-01-01

 
 
 
 
101

Case report 503: 1. Giant cell tumor of sacrum. 2. Fibrous histiocytoma of ischium (benign). 3. Fibrous histiocytoma of tibia (benign)  

International Nuclear Information System (INIS)

The radiological and pathological skeletal manifestations in a case of multicentric fibrohistiocytic tumor are presented. The authors have emphasized a possible common histiogenesis of the three lesions. In a review of the world literature, no other example of a giant-cell tumor of bone and benign fibrous histiocytoma in one and the same patient could be found, but references must be made to cases with multifocal giant-cell tumors of bone. Of interest, recently reports of experiences with intralesionally excised giant cell tumors with temporary methacrylate implantation lowering local recurrence rates have appeared. (orig.)

1989-01-01

102

Surgical Treatment of Benign Fibrous Histiocytoma as a Form of Intraspinal Extradural Tumor at Lumbar Spine  

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A benign fibrous histiocytoma (BFH) is one of the fibrohistiocytic groups of soft-tissue tumors for which spinal involvement is extremely rare. To the best of our knowledge, most spine-originating BFHs are bone tumors. We report the first case of BFH occurring in the intraspinal extradural space on the lumbar spine. A 66-year-old female presented with severe claudication symptom. The preoperative magnetic resonance images showed a huge intraspinal, extradural, thecal-sac-compressing soft-tiss...

Kim, Soo-beom; Jang, Jee-soo; Lee, Sang-ho

2010-01-01

103

Benign fibrous histiocytoma of the thoracic spine: case report and review of the literature.  

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Benign fibrous histiocytoma (BFH) is a rare skeletal tumor, accounting for approximately 1% of all surgically managed benign bone tumors. Spinal location is very rare, and its management can be challenging, involving excision of tumor and spinal reconstruction and stabilization. The prognosis is good after treatment. The authors present the case of BFH involving the thoracic spine and a review of the literature concerning BFH of the spine. PMID:16572628

Kuruvath, Sarin; O'Donovan, Dominic G; Aspoas, A Robert; David, Karoly M

2006-03-01

104

Malignant Fibrous Histiocytosis of upper end of humerus- A Case Report  

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Full Text Available Malignant fibrous histiocytoma, a type of sarcoma, is a malignant neoplasm ofuncertain originthat arises both in soft tissue and bone. Here we report a case ofMalignant Fibrous Histiocytosis (MFH of upper end of left humerus .Even though there are many cases of MFH reported in the bone, the incidencein upper end of humerus is rare. Histopathological examination many of the times isnot conclusive, as it is considered as a diagnosis of exclusion of sarcoma,which cannotbe more precisely categorized.

Sawarbandhe Sarang D1, and Arun Kumar Rao2

2012-12-01

105

Histiocitoma fibroso do saco lacrimal: relato de um caso / Lacrimal sac fibrous histiocytoma: case report  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Os autores descrevem um caso raro de histiocitoma fibroso acometendo o saco lacrimal. A paciente apresentava quadro clínico que simulava dacriocistite crônica, com dacriocistografia sugestiva de obstrução alta das vias lacrimais. A completa remoção cirúrgica do tumor e posterior dacriocistorrinostom [...] ia foram fundamentais no diagnóstico e controle da doença. Abstract in english The authors report an unusual case of fibrous histiocytoma of the lacrimal sac. The patient presented with clinical features of chronic dacryocystitis. Dacryocystogram disclosed a high level obstruction. Surgical management was fundamental to the diagnosis and control of the disease. [...

Carolina Lemos, Curi; Everaldo, Lemos; Eduardo Pereira de, Macedo; Virgínia Bohrer, Costa.

106

A CASE REPORT OF BENIGN FIBROUS HISTIOCYTOMA OF PARANASAL SINUSES AND ROLE OF TRANSNASAL ENDOSCOPY IN ITS TREATMENT  

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Full Text Available Benign fibrous histiocytoma is a rare tumor of nose and paranasal sinuses that originates from histiocytes. ??The main symptoms of patients are nasal obstruction and nasal mass. ?Our patient was presented with chief complaints of nasal obstruction and rhinorrhea non responsive to antibiotic treatment. In computed tomography scan a giant mass in left maxillary sinus and ipsilateral nasal cavity was seen. After en bloc resection of tumor by transnasal endoscopic approach all of patient’s symptoms were alleviated. The pathologic report was benign fibrous histiocytoma. ?Because of excellent visualization, it seems that transnasal endoscopic approach is the method of choice for resection of these benign tumors.

M. H. Baradaranfar M. Moghimi

2005-06-01

107

Benign fibrous histiocytoma of bone in a paediatric population: a report of 6 cases.  

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Case records and radiological investigations of six children with benign fibrous histiocytoma were studied retrospectively. BFH occurred in the femur (n = 2), tibia (n = 2) and fibula (n = 2). Clinically, patients reported pain from the lesion lasting several months (mean 6 months). The pain was not associated with pathological fracture in any patient. On X-rays, the lesions appeared as lytic and sharply demarcated with a sclerotic rim and fine trabeculations. The reported cases were located in the metaphysis and the diaphysis of the long bones. The tumour was restricted to bone, without periosteal or soft tissue reaction. Treatment consisted of careful intralesional curettage of the lesion; the defect was thereafter filled with bone bank graft or injectable phosphocalcic cement. The length of follow-up ranged from 24 months to 4.75 years (mean 35.2 months). One case presented with recurrence of the disease and required successful repeat intralesional curettage. Benign fibrous histiocytoma is probably underestimated among patients less than 20 years of age. This diagnosis should be considered in any child or teenager who presents with a non-ossifying fibroma accompanied by unexplainable pain or a rapid growing. Surgery restricted to the osteolytic lesion seems sufficient to achieve bone healing. PMID:21409501

Ceroni, D; Dayer, R; De Coulon, G; Kaelin, A

2011-08-01

108

Fibrohistiocitoma benigno ósseo na coluna lombar Benign fibrous histiocytoma of the lumbar spine  

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Full Text Available CONTEXTO: O fibrohistiocitoma benigno intra-ósseo é uma neoplasia rara, caracterizada por proliferação fibroblástica e fibras colágenas. A dor na região lombar é uma queixa freqüente em muitos pacientes, mas, na maioria das vezes está relacionada com causa muscular ou degenerativa. RELATO DE CASO: Relata-se aqui o caso de um paciente com diagnóstico de fibrohistiocitoma benigno ósseo na coluna lombar que apresentava queixa de lombalgia há cinco meses antes do diagnóstico. Foi submetida à biópsia aberta transpedicular na quarta vértebra lombar ,e, posteriormente realizada curetagem da lesão via anterior retroperitonial e artrodese vertebral de L3-L5 com enxerto de fíbula. CONCLUSÃO: Apesar de raro, o fibrohistiocitoma benigno intra-ósseo deve ser uma das hipóteses quando observamos uma lesão primária na coluna vertebral.CONTEXT: Benign intraosseous fibrous histiocytoma is a rare neoplasia, characterized by fibroblastic and collagenous fiber proliferation. Pain in the lumbar region is a frequent complaint in many patients, but most of times it is associated to muscular or degenerative causes. CASE REPORT: Here we report a case of a patient diagnosed with benign bone fibrous histiocytoma in the lumbar spine who complained of lumbar pain dating five months prior to diagnosis. The patient was submitted to open transpedicular biopsy in the forth lumbar vertebra, and subsequently, lesion curettage was performed via anterior retroperitoneal and L3-L5 vertebral arthrodesis using a fibular graft. CONCLUSION: Although rare, benign intraosseous fibrohistiocytoma should be taken into consideration when a primary lesion is observed in the spine.

Osmar Avanzi

2005-01-01

109

A Case Report: Angiomatoid Fibrous Histiocytoma in a 6-year-old Male and Review of the Literature.  

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Angiomatoid Fibrous Histiocytoma (AFH) is a distinctive tumor in children, adolescent and young adults which is slow growing with metastatic potential. The histogenesis of AFH is uncertain. Here, we present a case of AFH of 6-year-old on the trunk. In addition, the differential diagnosis for this lesion is also discussed. PMID:24521435

Kaygusuz, Ecmel Isik; Cetiner, Handan; Yorganci, Cuma; Celayir, Aysenur

2014-06-01

110

Deep benign fibrous histiocytoma: computed tomography and histology findings; Histiocitoma fibroso benigno profundo: achados na tomografia computadorizada e histologia  

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We present the computed tomography images of an 83-year-old male patient with a deep benign fibrous histiocytoma at the lateral aspect of the left leg. Computed tomography images showed a well-defined mass with marked peripheral enhancement by iodinated contrast medium. Only few reports of this rare soft tissue tumor can be found in the literature. (author)

Farage, Luciano; Castro, Mario Augusto Padula; Macedo, Tulio Augusto Alves [Uberlandia Univ., MG (Brazil). Hospital das Clinicas. Setor de Radiologia; Salomao, Eliana Chaves; Machado, Tania Alcantara; Souza, Lincoln Pereira de; Freitas, Luiz de Oliveira [Uberlandia Univ., MG (Brazil). Faculdade de Medicina. Dept. de Clinica Medica

2005-04-01

111

Malignant solitary fibrous tumour of the bronchus.  

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Solitary fibrous tumours most commonly present in the pleura, but have been reported in other extrapleural sites. We present a case of an elderly female who was found to have a malignant solitary fibrous tumour of the right upper lobe bronchus, treated with thoracoscopic lobectomy and bronchoplastic closure. PMID:23704712

Okereke, Ikenna C; Frick, Daniel J; Sheski, Francis D; Cummings, Oscar W

2014-01-01

112

Benign fibrous histiocytoma of the maxilla: a case report and review of literature.  

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Benign fibrous histiocytoma (BFH) is a mesenchymal tumor which commonly affects the skin of extremities. Histologically, BFH of soft tissues and bone shows similar features, but BFH of the bone is rare with less than 100 cases reported worldwide and usually it involves tibia, femur, and pelvic bone. As far as the oral cavity is concerned, majority of the BFHs are found in the soft tissues of the buccal mucosa, gingiva, lower and upper lips, soft palate, and floor of the mouth. Occurrence of this tumor in the jaw bones is extremely rare as only one case of the maxilla and six cases of the mandible have been reported so far . Hence, the purpose of this article is to report the second case of BFH of the maxilla in a 23-year-old female patient and to review the literature of this entity affecting the jaws. PMID:24748313

Saluja, Harish; Kasat, Vikrant O; Rudagi, Bhimmapa M; Dehane, Vipin; Kalburge, Jitendra V; Nikam, Atul

2014-01-01

113

Malignant solitary fibrous tumor of the esophagus.  

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Solitary fibrous tumor (SFT) of the esophagus has been very rarely reported in literature. Herein, we report a case of a successful surgically treated malignant solitary fibrous tumor of the esophagus. A 36-year-old woman was admitted at our hospital with an erroneous ultrasound-based diagnosis of cervico-mediastinal goiter. Surprisingly, the preoperative diagnostic work-up, including a computed tomographic chest scan, endoscopy, and endoscopic ultrasonography, revealed a pedunculated intraluminal mass in the esophagus. The tumor was radically removed through left antero-lateral cervicotomy. Pathologic and immunohistochemical examination was concluded for a malignant SFT, a rare variant not previously described in relation to the esophagus. The patient underwent adjuvant radiotherapy and is alive with no signs of tumor recurrence 32 months after surgery. PMID:20817543

Lococo, Filippo; Cesario, Alfredo; Mulè, Antonino; Margaritora, Stefano

2011-04-01

114

Fibrohistiocitoma conjuntival simulando pterígio atípico na região amazônica: relato de caso Conjunctival fibrous histiocytoma simulating atipical pterygium in the Amazon region: case report  

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Full Text Available Relatamos um caso inédito na literatura brasileira de fibrohistiocitoma conjuntival descoberto durante projeto comunitário de larga escala realizado pela equipe do Centro de Referência em Oftalmologia do Hospital das Clínicas da Universidade Federal de Goiás na região amazônica. Paciente do sexo feminino, leucoderma, de 38 anos de idade, apresentava lesão vascularizada no olho direito no canto medial da conjuntiva bulbar e carúncula com extensão para o limbo e invadindo cerca de 2 mm da córnea medial com configuração semelhante a um pterígio. O exame histopatológico revelou lesão constituída por células fusiformes, com arranjo estoriforme e células histiocitárias gigantes. A imunohistoquímica revelou forte positividade para vimentina e as células neoplásicas foram negativas para AE1/ AE3, HMB 45, proteína S 100. O diagnóstico histopatológico foi de fibrohistiocitoma. A evolução poderá demonstrar o crescimento tumoral e a possibilidade de lesão maligna.An inedited case in the Brazilian literature of conjunctival fibrous histiocytoma discovered during a wide scale community project accomplished by the team of the Center of Reference in Ophthalmology of the Hospital das Clínicas da Universidade Federal de Goiás in the Amazon region is reported. A 38 year-old caucasian woman presented with a vascularized lesion on the medial portion of the bulbar conjunctiva and caruncular region of the right eye with extension for the limbus and invading about 2 mm of the medial cornea resembling a pterygium. Pathologic findings revealed that the lesion was constituted by spindle-shaped cells, with storiform arrangement, and large histocytelike cells. The immunohistochemistry revealed strong positivity for vimentin and the neoplastic cells were negative for AE1/AE3, HMB 45, S 100 protein. The histopathologic diagnosis was fibrous histiocytoma. The evolution demonstrated the tumoral growth and the possibility of a malignant lesion.

Roberto Murillo Limongi de Souza Carvalho

2010-12-01

115

Malignant transformation of fibrous dysplasia into chondroblastic osteosarcoma  

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A case of malignant transformation of polyostotic fibrous dysplasia into maxillary chondroblastic osteosarcoma is presented. The clinical, radiographic, CT, MR imaging features and pathological findings of polyostotic fibrous dysplasia and its malignant transformation are described. Malignant transformation of fibrous dysplasia is rare and has not previously been described in the English literature in this location in McCune-Albright syndrome and in the absence of radiation treatment. (orig.)

2002-02-01

116

Fibrous histiocytoma (fibroxanthoma) of a cervical vertebra. A report with a review of the literature  

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A patient with a benign appearing intraosseous fibrous lesion of the cervical verebra is presented. The lesion had the histologic features of nonossifying fibroma (metyphyseal fibrous defect).Because of its atypical location and unusual radiologic appearance, the lesion was diagnosed as a fibrous histocytoma, a tumor whose histology is similar to non-ossifying fibroma. The literature was reviewed for similar cases located outside the metaphyses of the long bones. Support is given for designating such lesions as fibrous histocytomas rather than non-ossifying fibromas.

Destouet, J.M.; Gilula, L.A.; Kyriakos, M.

1980-01-01

117

A rare case of fibrous histiocytic tumor of the tongue.  

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Fibrous histiocytoma is a benign soft tissue tumor composed of a mixture of fibroblastic and histiocytic cells arising as a fibrous mass everywhere in the human body. Based on location it is divided into cutaneous type and those involving the deeper tissues. Involvement of the oral cavity is rare. It is important to distinguish this tumor from the more aggressive forms of fibrohistiocytic neoplasm including dermatofibrosarcoma protuberans and malignant fibrous histiocytoma (FH) (7).The clinical and histiological diagnosis, treatment, and prognosis of FH have been discussed. PMID:24426494

Pandey, Narendra Kumar; Sharma, Sushant Kumar; Banerjee, Sandip

2013-06-01

118

Malignant Solitary Fibrous Tumor of the Nasal Cavity  

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Solitary fibrous tumors (SFTs) are unusual mesenchymal tumors that were first described as primary spindle-cell neoplasms of the pleura. These tumors have been described in many other locations, including the urogenital system, orbit, mediastinum, and upper respiratory tract. Twenty-two cases of an SFT of the paranasal sinuses and nasal cavity have been reported, but none described a malignant SFT extending through the anterior skull base. A 70-year-old man had a 6-month history of unilateral...

Zeitler, Daniel M.; Kanowitz, Seth J.; Har-el, Gady

2007-01-01

119

Malignant solitary fibrous tumor in anterior mediastinum with pleural metastasis simulating invasive thymoma  

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Malignant solitary fibrous tumor, which arises in the anterior mediastinum, is rare. Its image findings simulate other mediastinal mass, such as malignant lymphoma, malignant thymic epithelial tumor or invasive thymoma. Here, we report a pleural malignant fibrous tumor of a 60 year old man who is presented with a well defined lobulating anterior mediastinal mass with pleural metastasis mimicking invasive thymoma with pleural seeding.

Kim, Jong Bum; Lee, Ju Won; Kim, Youn Jeong; Kim, Yeo Ju; Lee, Kyung Hee; Chu, Young Chae; Song, Ju Young; Yoon, Yong Han [Inha Univ. School of Medicine/Inha Univ. Hospital, Incheon (Korea, Republic of)

2012-05-15

120

Malignant solitary fibrous tumor in anterior mediastinum with pleural metastasis simulating invasive thymoma  

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Malignant solitary fibrous tumor, which arises in the anterior mediastinum, is rare. Its image findings simulate other mediastinal mass, such as malignant lymphoma, malignant thymic epithelial tumor or invasive thymoma. Here, we report a pleural malignant fibrous tumor of a 60 year old man who is presented with a well defined lobulating anterior mediastinal mass with pleural metastasis mimicking invasive thymoma with pleural seeding

2012-05-01

 
 
 
 
121

Primary malignant fibrous histiocytoma of the breast: report of one case  

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Caigang Liu,1 Zuowei Zhao,1 Qingfu Zhang,2 Yunfei Wu,3 Feng Jin3 1Department of Breast Surgery, Second Hospital of Dalian Medical University, Dalian, People's Republic of China; 2Department of Pathology, First Hospital of China Medical University, Shenyang, People's Republic of China; 3Department of Breast Surgery, General Surgery, First Hospital of China Medical University, Shenyang, People's Republic of China. Abstract: Seven years ago, a 48-year-old female patient discovered a ...

2013-01-01

122

Benign Paratesticular Fibrous Pseudotumor With Malignant Clinical Features  

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Paratesticular tumors are rare intrascrotal masses that grow mainly in structures containing connective tissue around the testis, epididymis, or spermatic cord. We report here on a case of a 55-year-old man with a mass in the hemiscrotum that was found to be a paratesticular fibrous pseudotumor in the orchiectomy specimen pathologic examination. From this case report and literature review, a diagnostic and therapeutic strategy is demonstrated for the management of this uncommon lesion.

Khallouk, Abdelhak; Ahallal, Youness; Tazi, Elmehdi; Tazi, Mohammed Fadl; Elfassi, Mohammed Jamal; Farih, Moulay Hassan

2011-01-01

123

Primary malignant mesenchymoma of bone  

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Full Text Available Pimary malignant mesenchymoma of bone (PMMB is an exceedingly rare neoplasm consisting of two or more unrelated malignant mesenchymal components other than fibrosarcoma or malignant fibrous histiocytoma. Review of the literature reports only 16 cases, most of which were composed of osteosarcoma and liposarcoma. We report a case af PMMB composed of liposarcoma,rhabdomyosarcoma and high grade chondrosarcoma arising within the left distal femur in a 52-year-old male, resulting in the patient's death 3 months after presentation. (Med J Indones 2001;10: 235-41Keywords: Bone tumor-malignancy, liposarcoma, dedifferentiated chondrosarcoma, rhabdomyosarcoma

Errol U. Hutagalung

2001-12-01

124

Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature.  

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Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm that most often involves the pleura, rarely occurring in extra-thoracic locations. Twenty-six cases of SFT arising in the thyroid gland have been described. We report a case of a 60-year-old woman presenting an 8-month history of enlargement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisable. PMID:24936737

Alves Filho, Wellington; Mahmoud, Renata Regina da Graça Lorencetti; Ramos, Daniel Marin; Araujo-Filho, Vergilius José Furtado de; Lima, Patricia Picciarelli de; Cernea, Claudio Roberto; Brandão, Lenine Garcia

2014-06-01

125

Renal malignant solitary fibrous tumor with single lymph node involvement: report of unusual metastasis and review of the literature  

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Solitary fibrous tumors are rare mesenchymal spindle cell neoplasms that are usually found in the pleura. The kidneys are an uncommon site and only few cases of renal solitary fibrous tumor exhibit malignant behavior metastasizing to the liver, lung, and bone through the hematogenous pathway. Purpose To describe the first case of lymph node metastasis from renal solitary fibrous tumor in order to increase the knowledge about the malignant behavior of these tumors. Patients and methods A 19-year-old female patient had intermittent hematuria for several months without flank pain or other symptoms. A chest and abdomen CT scan was performed and showed a multi-lobed bulky solid mass of 170 × 98 × 120 mm in the left kidney. One day before the surgery, the left renal artery was catheterized and the kidney embolization was performed using a Haemostatic Absorbable Gelatin Sponge and polyvinyl alcohol. We then performed a radical nephrectomy with hilar, para-aortic, and inter-aortocaval lymphadenectomy. Results Estimated intraoperative blood loss was 200 mL and the operative time was 100 minutes. No postoperative complications occurred. The hospital stay was 7 days long. The histological examination was malignant solitary fibrous tumor of the kidney. Cancerous tissue showed cellular atypia, with an increased mitotic index (up to 7 × 10 hpf). Immunohistochemical analysis showed positive results for CD34, BCL2, partial expression of HBME1, and occasionally of synaptophysin. Histological evaluation confirmed the presence of metastasis in one hilar node. The patient did not receive any other therapy. At 30-month follow-up, the patient was in good health and no local recurrence or metastases had occurred. Conclusion This is the first case of lymph node metastasis from a renal solitary fibrous tumor showing unusual malignant behavior; this finding adds new information about the biology and progression of these tumors, which remain unclear.

Mearini, Ettore; Cochetti, Giovanni; Barillaro, Francesco; Fatigoni, Sonia; Roila, Fausto

2014-01-01

126

Renal malignant solitary fibrous tumor with single lymph node involvement: report of unusual metastasis and review of the literature  

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Full Text Available Ettore Mearini,1 Giovanni Cochetti,1 Francesco Barillaro,1 Sonia Fatigoni,2 Fausto Roila2 1Department of Medical-Surgical Specialties and Public Health, Division of Urological Andrological Surgery and Minimally Invasive Techniques, University of Perugia, Terni, Italy; 2Medical Oncology, S Maria Hospital, Terni, Italy Abstract: Solitary fibrous tumors are rare mesenchymal spindle cell neoplasms that are usually found in the pleura. The kidneys are an uncommon site and only few cases of renal solitary fibrous tumor exhibit malignant behavior metastasizing to the liver, lung, and bone through the hematogenous pathway. Purpose: To describe the first case of lymph node metastasis from renal solitary fibrous tumor in order to increase the knowledge about the malignant behavior of these tumors. Patients and methods: A 19-year-old female patient had intermittent hematuria for several months without flank pain or other symptoms. A chest and abdomen CT scan was performed and showed a multi-lobed bulky solid mass of 170 × 98 × 120 mm in the left kidney. One day before the surgery, the left renal artery was catheterized and the kidney embolization was performed using a Haemostatic Absorbable Gelatin Sponge and polyvinyl alcohol. We then performed a radical nephrectomy with hilar, para-aortic, and inter-aortocaval lymphadenectomy. Results: Estimated intraoperative blood loss was 200 mL and the operative time was 100 minutes. No postoperative complications occurred. The hospital stay was 7 days long. The histological examination was malignant solitary fibrous tumor of the kidney. Cancerous tissue showed cellular atypia, with an increased mitotic index (up to 7 × 10 hpf. Immunohistochemical analysis showed positive results for CD34, BCL2, partial expression of HBME1, and occasionally of synaptophysin. Histological evaluation confirmed the presence of metastasis in one hilar node. The patient did not receive any other therapy. At 30-month follow-up, the patient was in good health and no local recurrence or metastases had occurred. Conclusion: This is the first case of lymph node metastasis from a renal solitary fibrous tumor showing unusual malignant behavior; this finding adds new information about the biology and progression of these tumors, which remain unclear. Keywords: solitary fibrous tumor, sarcoma, kidney, lymph node metastases, lymphadenectomy

Mearini E

2014-05-01

127

Paraneoplastic hypoglycemia in a patient with a malignant solitary fibrous tumor  

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Summary Hypoglycemia is a common medical emergency. It is the most frequent complication induced by anti-diabetic treatment. However, it can be observed in other conditions unrelated to diabetes such as insulinoma, autoimmune disorders, and neoplasia. Herein, we report the case of a rare cause of severe and recurrent hypoglycemia in a 77-year-old woman with a malignant solitary fibrous tumor (MSFT). A 77-year-old woman was admitted to the emergency department for loss of consciousness induced by severe hypoglycemia. Her standard laboratory findings were unremarkable. HbA1c, albumin, renal, liver, thyroid, and adrenal function tests were normal. Cerebral CT scan was also normal. At the time of confirmed hypoglycemia, the serum level of insulin and C-peptide was low. On the basis of the past medical history and the absence of other comment etiologies, a paraneoplastic cause was suspected. Thus, the diagnosis of a non-islet cell tumor-induced hypoglycemia (NICTH) was established by the presence of incompletely processed precursors of IGF2 (big IGF2) in plasma electrophoresis. However, the IGF1 level was low. Therapy with corticosteroids improved hypoglycemia and clinical symptoms. NICTH is a rare cause of hypoglycemia. It should be considered in patients with mesenchymal or malignant epithelial tumors suffering from recurrent episodes of hypoglycemia. The diagnosis will be established in the case of low serum insulin concentrations and elevated levels of big IGF2. Treatment with corticosteroids, GH, or both can improve hypoglycemic symptoms and restore plasma glucose to normal levels. Learning points NICTH is a very rare condition that should be considered in patients known to have mesenchymal or malignant epithelial tumors and suffering from recurrent episodes of hypoglycemia.The diagnosis of an NICTH is established on the basis of the hypoinsulinemic hypoglycemia, the MSFT history, and the presence of paraneoplastic secretion of IGF1 or an immature form of IGF2.Treatment with corticosteroids, GH, or both can improve hypoglycemic symptoms and restore plasma glucose to normal levels in NICTH.

Mohammedi, Kamel; Abi Khalil, Charbel; Olivier, Sophie; Benabad, Imane; Roussel, Ronan; Marre, Michel

2014-01-01

128

Epithelioid Cell Histiocytoma – An Unusual Variant of Dermatofibroma at an Uncommon Site  

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Full Text Available Epithelioid cell histiocytoma (ECH is a rare variant of cutaneous fibrous histiocytoma involving primarily trunk and the extremities. It can delude the pathologist in considering other benign non neoplastic and neoplastic lesions. Awareness of this new entity can avert unnecessary treatment. We report a case of epithelioid cell histiocytoma in a 40 yr old male who presented with a painless nodular swelling over the dorsum of nose. The case is presented here for its rarity and an uncommon site of involvement.

Shulbha VS

2011-04-01

129

Generalized eruptive histiocytoma  

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We are reporting a 62 year old male, who over a period of 1 year, developed a symmetric eruption of hundreds of brownish papules, with spontaneous regression of some lesions. The clinical and histopathological findings were compatible with the diagnosis of generalized eruptive histiocytoma.

Aggarwal, Kamal; Gupta, Sanjeev; Jain, Vijay Kumar; Sen, Rajeev; Gupta, Sunita

2010-01-01

130

CT of malignant soft tissue tumor  

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CT provides excellent anatomic detail of soft tissue tumors and precise location, size, extent of the tumor and its effect on adjacent organs. We evaluated CT findings of 13 cases of soft tissue tumors which proven pathologically during recent 4 years. There were 7 cases of liposarcoma, 4 cases of rhabdomyosarcoma, one of leiomyosarcoma and one case of malignant fibrous histiocytoma. CT was often characteristic to diagnose specific histology of soft tissue tumor. Well differentiated liposarcoma showed predominant fat density with internal septation. Rhabdomyosarcoma in children showed inhomogeneous density and peripherally enhanced rim.

1988-08-01

131

PET/CT in benign and malignant musculoskeletal tumors and tumor-like conditions.  

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This article briefly reviews malignant bone tumors, diffuse marrow infiltrating diseases, and other benign bone diseases with fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT) that should be differentiated from malignant tumors. Clinical use of FDG PET/CT in (1) primary malignant bone tumors including osteosarcoma, malignant fibrous histiocytoma, and primary bone lymphoma, (2) hematopoietic tumors with bone marrow involvement, such as plasmacytoma, multiple myeloma, lymphoma and leukemia, and (3) benign tumors and tumor-like lesions including hemangioma, neurogenic tumor, fibrous dysplasia, and nodular fasciitis are presented, with an emphasis on various imaging findings on FDG PET/CT. Benign tumors and tumor-like conditions are often incidentally detected on FDG PET/CT in serial follow-up studies of cancer patients and should be differentiated from metastasis. PMID:24715446

Choi, Yun Young; Kim, Ji Young; Yang, Seoung-Oh

2014-04-01

132

Sorafenib in patients with progressive malignant solitary fibrous tumors: a subgroup analysis from a phase II study of the French Sarcoma Group (GSF/GETO).  

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Malignant solitary fibrous tumors are rare soft-tissue sarcomas. They are considered as low-grade malignancies, but may display metastatic potential in 20% of the cases. In case of metastatic or locally advanced, unresectable disease, standard treatments, like anthracycline-based regimens, are poorly effective. Previous studies suggested that antiangiogenic drugs, such as sorafenib, could be efficient to treat vascular sarcomas and solitary fibrous tumors. Five patients with progressive SFT were included in this phase 2 study, and treated with sorafenib at a dose of 800 mg daily. Two patients out of the five achieved a 9 months disease control with sorafenib, while their disease had progressed within the month preceding their inclusion. Consequently, our data suggest a potential efficacy of sorafenib in SFT, Further investigation is needed to confirm these data. PMID:24005614

Valentin, T; Fournier, C; Penel, N; Bompas, E; Chaigneau, L; Isambert, N; Chevreau, C

2013-12-01

133

Doege-Potter syndrome presenting with hypoinsulinemic hypoglycemia in a patient with a malignant extrapleural solitary fibrous tumor: a case report  

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Full Text Available Abstract Introduction Doege-Potter syndrome is a paraneoplastic syndrome characterized by non-islet cell tumor hypoglycemia secondary to a solitary fibrous tumor. This tumor causes hypoglycemia by the secretion of a prohormone form of insulin-like growth factor II. We describe the diagnosis and management of Doege-Potter syndrome and the use of transarterial chemoembolization in a patient with a malignant extrapleural solitary fibrous tumor. Case presentation Our patient was a 64-year-old Caucasian woman who initially presented with urinary incontinence and was found to have a 14.5×9.0×9.0cm retroperitoneal solitary fibrous tumor compressing her bladder. Her tumor was surgically resected but recurred with multiple hepatic metastatic lesions. The hepatic metastases progressed despite systemic chemotherapy and treatment with doxorubicin transarterial chemoembolization. Her course was complicated by the development of recurrent fasting hypoglycemia, most likely secondary to Doege-Potter syndrome. Her hypoglycemia was managed with corticosteroid therapy and frequent scheduled nutrient intake overnight. Conclusions The rarity of hepatic solitary fibrous tumors and consequent lack of controlled trials make this report significant in that it describes the diagnostic approach to Doege-Potter syndrome, describes our experience with the use of doxorubicin transarterial chemoembolization, and presents management options for tumor-associated hypoglycemia in the case of extensive disease not amenable to surgical resection.

Schutt Robert C

2013-01-01

134

De novo malignant transformation of giant cell tumor of bone  

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Two cases of malignant lesions are reported, both of which arose secondary to an originally benign giant cell tumor (GCT) of bone. The first case was a typical benign GCT, which occurred in the left proximal tibia of a 31-year-old woman. The tumor was treated by curettage and bone grafting. However, it recurred twice during 15 years of follow-up. The second recurrence showed that the lesion histologically had turned into malignant fibrous histiocytoma. The second case also started as an initially benign GCT that arose in the left distal femur of a 41-year-old man. The patient underwent curettage and bone grafting. The lesion recurred 13 years postoperatively. The histological appearance of the recurrent tumor showed it to be an osteogenic sarcoma. In both patients, radiation had never been given. Malignant transformation has rarely been reported in patients with GCT of bone who have not received radiation treatment. (orig.)

2001-02-01

135

Accumulation of leucocytes labelled with technetium-99m hexamethylpropylene amine oxime in malignant abdominal tumours  

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A total of 343 leucocyte scans labelled with technetium-99m hexamethylprophylene amine oxime were reviewed that had been performed patients suspected of having abdominal infection or inflammation. There was uptake by malignant abdominal tumours in 10 cases (2,9%), which represents 62.5% of known malignancies at the time of the scintigram. Accumulation was seen in 8 patients with adenocarcinoma of the colon associated with a secondary infection in the tumour or pericolic inflammation. A large tumour that had spread beyond the bowel wall was related to a positive scintigram. Accumulation was also found twice in a malignant fibrous histiocytoma in which bleeding and an inflammatory reaction to necrosis were probably responsible for the uptake. The relevant treatment was delayed for 2 weeks-2 months in 4 patients with adenocarcinoma of the colon in whom the positive uptake was regarded as confirmation of the clinically suspected cute diverticulitis. (orig.)

1991-01-01

136

Diabetic fibrous mastopathy.  

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Diabetic fibrous mastopathy is an uncommon self-limiting fibroinflammatory diseae of the breast that is seen predominantly in premenopausal women with long standing type I (insulin dependent) diabetes mellitus. In this report, we present a 29 years old female with uncontrolled diabetes mellitus presenting with bilateral breast masses which were irregular and hypoechoic on ultrasound, gradual enhancement on MRI and diagnosed as diabetic fibrous mastopathy on histopathology. It is quite difficult to distinguish it from malignancy on mammographic and ultrasonographic features or clinical findings. Correlation of the pathological features may help to make the correct diagnosis for this disease. PMID:24717992

Gunduz, Yasemin; Tatli, Lacin; Kara, Rabia Oztas; Cakar, Gozde Cakirsoy; Akdemir, Nermin; Dilek, Fatma Hüsniye

2014-03-01

137

Special diagnostic problems in primary malignant bone tumors  

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The diagnosis of primary malignant bone tumors, which only account for 1% of malignancies in humans, represents quite a challange for the pathologist. Apart from the often overlapping morphology between different entities, heterogeneity within one and the same tumor has to be kept in mind. Furthermore, in most cases the diagnosis must be established based on small biopsy specimens and occasionally even on frozen sections. In this context detailed clinical information including the patient's age and exact localization of the tumor, as depicted by X-ray or MRI, are essential requirements for a correct diagnosis. In addition, multiple biopsies from different tumor sites may be of help. For example, 25% of osteogenic sarcomas (OSA) are chondroplastic. Others may contain areas similar to fibrosarcoma (FSA) or malignant fibrous histiocytoma (MFH). Since 90% of OSA occur in the second decade of life whereas chondrosarcomas, FSA and MFH usually manifest after the age of 40 years, a biopsy solely composed of malignant chondromatous tissue obtained from a tibial lesion of a 10-year-old child should most likely be considered as part of an OSA. In the differential diagnosis of the so-called small, round cell tumors, which include Ewing sarcoma, malignant lymphoma and small-cell OSA, immunohistochemical staining of the paraffin-embedded material and a molecular biological/genetic work-up of frozen material are most helpful. In this paper the histomorphological characteristics and criteria for differential diagnosis of the most common primary malignant bone tumors are discussed. (orig.)

1998-06-01

138

Fibrous Dysplasia  

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... ray of the lesion from Figure 1 after curettage, bone grafting, and fixation with a metal plate ... or to prevent bone breakage. Additionally, scooping out (curettage) of the fibrous dysplasia is generally performed along ...

139

CT findings of uncommon malignant tumors of the liver  

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Objective: To improve the diagnostic level of uncommon hepatic malignancy in 5 cases with different histopathological nature by analyzing their CT features. Methods: CT scan was performed in 5 cases with pathologically proved uncommon malignancy of the liver including hepatic sarcoma (n=3) and primary carcinoid tumor (n=2). Results: These uncommon malignancies of the liver had a variety of presentations. Undifferentiated embryonal sarcoma presented as a single huge cyst mixing with solid mass. Hepatic angiosarcoma demonstrated as multiple well-defined hypoattenuation lesions without cirrhosis. Necrosis, cystic degeneration, and hemorrhage may be accompanied. Malignant fibrous histiocytoma displayed as a single large hypoattenuation lesion within hyperdense septations, and most of the tumor was in the right lobe. Immunohistochemistry had the diagnostic value. The CT features of carcinoid tumor were single or multiple, unilocular or multilocular mixed-dense masses. The solid portion of the masses enhanced obviously and carcinoid syndrome may highly suggest the diagnosis. Conclusion: The forementioned 5 cases of hepatic malignancy are seldom seen clinically. Each of them with different pathologic nature has different CT findings, and sometimes with some similar signs. Typical CT findings, coupled with clinical information may lead to a correct diagnosis

2003-06-01

140

Ureteral fibrous polyp: Report of 2 cases  

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Two cases of ureteral fibrous polyp showing serpiginous filling defect on IVP are presented with characteristic radiologic features; easy flow of contrast medium around polyp, prolapsed polyp in urinary bladder, and less ureteral obstruction or renal damage than in epithelial lesions. These radiologic findings enable to differentiation of ureteral fibrous polyps from malignant tumors, which is helpful for determining therapeutic approach

1992-03-01

 
 
 
 
141

Quantification of the magnetization-transfer contrast effect: can it yield additional information in differentiation of musculoskeletal lesions particularly in separation of benign from malignant lesions  

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Purpose: To investigate the potential information of the amount of magnetization-transfer effect in musculoskeletal lesions and to compare MT ratios from benign and malignant musculoskeletal lesions. Material and Method: 49 patients with malignant tumors (3 osteosarcoma, 3 malignant fibrous histiocytoma, 4 chondrosarcoma, 2 Ewing sarcomas) and benign lesions (8 chondroma, 2 fibrous dysplasia, 3 osteoid-osteoma, 6 ganglion cyst, 3 cyst, 3 osteomyelitis, 4 tendinitis, 3 rotator cuff tear, 5 scar tissue) were scanned using routine MRI protocols including T1- and T2-weighted spin echo as well as T2*-weighted gradient echo (FFE) sequences at 1.5 Tesla (ACS II, Philips Medical). Additionally MTC images were generated by combining the FFE sequence and the off-resonance MT technique (-1500 Hz off-resonance frequency, 1770 flip angle and 50 ms pulse duration). MT ratios were calculated as SIo-SIm/SIo. Results: The MT ratio of benign lesions was 26±15%, that of malignant lesions was 22±6%. The difference was statistically not significant. As expected muscle showed a high MT ratio of 50±8%. Scar tissue demonstrated an MT ratio of 39±16% which was significantly higher than the tumor MT ratios. Conclusion: MTC (MT ratios) failed to show significant differences between benign and malignant lesions as was expected due to basic differences in cellularity, rate of mitosis and chromatin content. MTC might however gain more importance in separating scar tissue from recurrent tumor in the future. (orig.)

1999-12-01

142

Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor.  

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Well documented examples of primary malignant giant cell tumor of bone (giant cell tumor and concurrent sarcoma arising de novo) are exceedingly rare in the literature. We report a case arising in the left ischium of a 44-yr-old man. He had no previous history of radiation therapy or multiple resections. Histologically, the tumor was a typical giant cell tumor of bone juxtaposed to a malignant fibrous histiocytoma (MFH). The juxtaposition of a high grade sarcoma (MFH) and a locally aggressive nonmalignant neoplasm such as giant cell tumor is analogous to several other tumors of bone and soft tissue in which a low grade malignant or locally aggressive tumor can be associated with MFH or fibrosarcoma de novo, namely chondrosarcoma, chordoma, liposarcoma, and well differentiated intraosseous and parosteal osteosarcoma. The presence of a high grade malignant component in each of the aforementioned neoplasms generally portends a more ominous prognosis, although this is not invariably true. Recognition of the phenomenon of "dedifferentiation" (or tumor progression) in some bone tumors and sarcomas is important to ensure appropriate treatment. Distinction from secondary malignant giant cell tumors which are usually radiation induced is also important, since the latter have a much worse prognosis than those with dedifferentiation occurring de novo. PMID:2554283

Meis, J M; Dorfman, H D; Nathanson, S D; Haggar, A M; Wu, K K

1989-09-01

143

Definitive intraoperative radiotherapy for musculoskeletal sarcomas and malignant lymphoma in combination with surgical excision  

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The purpose was to estimate retrospectively the outcome of patients with musculoskeletal sarcoma or malignant lymphoma treated with intraoperative radiotherapy (IORT). Between 1988 and 1999, definitive IORT in combination with surgical excision was performed in 24 patients with musculoskeletal sarcoma (malignant fibrous histiocytoma, 10; osteosarcoma, 6; liposarcoma, 2; chondrosarcoma, 1; synovial sarcoma, 1; Ewing's sarcoma, 1; angiosarcoma, 1; epithelioid sarcoma, 1; malignant schwannoma, 1; and 3 patients with malignant lymphoma. The tumor was excised by marginal margin excision, intralesional margin excision, or wide margin excision; 15-45 Gy electrons was then delivered to the affected sites. In the 8 patients without distant metastases at the first visit, 4 patients are alive 6.5-11.5 years after IORT, and 4 patients died <4.5 years after IORT. The incidence of local recurrence was 13%. In the 19 patients with distant metastases at the first visit, 3 patients are alive 2.5-6.7 years after IORT, and 16 patients died 0.2-5.7 years after IORT. The incidence of local recurrence was 45%. Complications after IORT were found in 5 patients: neuropathy, 1 patient; skin necrosis, 1 patient; myelopathy, 1 patient; enteritis ileus, 1 patient; and edema, 1 patient. IORT with a radiation dose of 15-45 Gy in combination with surgical excision appeared to be useful for local control and to be more effective in patients without distant metastases at the first visit than in patients with distant metastases. (author)

2003-06-01

144

The Study of the Malignant Tumors of the Maxillary Sinus by Computed Tomography  

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CT findings of proven 25 malignant tumors of the maxillary sinus were retrospectively analyzed to be of help in the diagnosis and treatment. The results were as follow: 1. Average age was 54 years old, and eighteen were males and seven were females with a ratio of 2.6:1. 2. The most common histopathologic feature was squamous cell carcinoma (19 cases) and others were two cases of adenoid cystic carcinoma, one case of malignant fibrous histiocytoma, mucoepidermoid tumor, histiocytic lymphoma, unidentified malignant tumor. 3. CT findings were sinus opacification (4%), soft tissue mass (92%), low densities within soft tissue mass (44%), air densities within soft tissue mass (24%), osteosclerosis (4%), bone destruction (92%), bone displacement (32%), fat plane obliteration(76%). 4. CT in the malignant maxillary sinus tumors approved the value in evaluation of tumor extension to nasal cavity, ethmoid sinus, orbit, infratemporal fossa, pterygopalatine fossa, pterygoid fossa, pterygoid muscle, cheek skin and intracranial cavity. 5. Twenty four cases (96%) were stage III, stage IV according to AJCC TNM classification. 6. Bone findings were destruction, displacement, sclerosis and most frequent site of bone destruction was the medial wall of the antrum (92%). 7. Tumor growth pattern showed destructive pattern in 18 cases (72%), and squamous cell carcinoma showed destructive pattern. (p<0.05).

Dan, Jung Bae; Park, Tae Won [Dept. of Oral Radiology, College of Dentistry, Seoul National University, Seoul (Korea, Republic of)

1989-11-15

145

The Study of the Malignant Tumors of the Maxillary Sinus by Computed Tomography  

International Nuclear Information System (INIS)

CT findings of proven 25 malignant tumors of the maxillary sinus were retrospectively analyzed to be of help in the diagnosis and treatment. The results were as follow: 1. Average age was 54 years old, and eighteen were males and seven were females with a ratio of 2.6:1. 2. The most common histopathologic feature was squamous cell carcinoma (19 cases) and others were two cases of adenoid cystic carcinoma, one case of malignant fibrous histiocytoma, mucoepidermoid tumor, histiocytic lymphoma, unidentified malignant tumor. 3. CT findings were sinus opacification (4%), soft tissue mass (92%), low densities within soft tissue mass (44%), air densities within soft tissue mass (24%), osteosclerosis (4%), bone destruction (92%), bone displacement (32%), fat plane obliteration(76%). 4. CT in the malignant maxillary sinus tumors approved the value in evaluation of tumor extension to nasal cavity, ethmoid sinus, orbit, infratemporal fossa, pterygopalatine fossa, pterygoid fossa, pterygoid muscle, cheek skin and intracranial cavity. 5. Twenty four cases (96%) were stage III, stage IV according to AJCC TNM classification. 6. Bone findings were destruction, displacement, sclerosis and most frequent site of bone destruction was the medial wall of the antrum (92%). 7. Tumor growth pattern showed destructive pattern in 18 cases (72%), and squamous cell carcinoma showed destructive pattern. (p<0.05).

1989-11-01

146

Diagnostic significance of MRI in malignant skin tumors  

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For surgical treatment of malignant tumors, it is important to clarify the depth and area of invasion of tumors and the relation to surrounding normal tissues such as adipose tissue, muscles and bones in addition to the histological diagnosis of the tumors before operation. For this purpose we clinically evaluated a magnetic resonance imaging (MRI) for diagnosing skin tumors. A MRI, SIGNA (GE), which analyzes the tumors by a spin echo method (TR 1500, TE 20) was used in this study, and 29 slices of MRI in a tumor were accumulated crossing those tumors. The usefulness of three dimensional presentation of skin tumors performed by the MRI data was also discussed. For three dimensional presentation, VoxelflingerTM was applied and those images were compared with cross section of those tumors during operation and histological specimens. We applied the MRI examination on patients with malignant melanoma, malignant fibrous histiocytoma, fibrosarcoma and squamous cell carcinoma of skin. The MRI was a very useful tool to clarify the depth and area of invasion of malignant tumors and the relation to surrounding normal tissues. The effects of MRI was most remarkable when applied on patients with malignant melanoma of soles. Three dimensional presentation obtainned from the MRI data was also useful to know three dimensional condition of those tumors but it seems still to have limitation because of the analytical software of the computer. In conclusion, we suggest that MRI should be the imaging modality of choice in evaluating skin tumors especially of the extremities, and three-dimensional analysis will be beneficial as well as that of using slice images in the future. (author)

1994-08-01

147

38 CFR 3.309 - Disease subject to presumptive service connection.  

Science.gov (United States)

...mesothelioma) Note 1: The term âsoft-tissue sarcomaâ includes the following: Adult fibrosarcoma Dermatofibrosarcoma protuberans Malignant fibrous histiocytoma Liposarcoma Leiomyosarcoma Epithelioid leiomyosarcoma...

2009-07-01

148

FDG-PET for preoperative differential diagnosis between benign and malignant soft tissue masses  

International Nuclear Information System (INIS)

To evaluate the standardized uptake value (SUV) of [18F]2-deoxy-2-fluoro-d-glucose at positron emission tomography (FDG-PET) for preoperative differential diagnosis between benign and malignant soft tissue masses.Design One hundred and fourteen soft tissue masses (80 benign, 34 malignant) were examined by FDG-PET prior to tissue diagnosis. The SUVs were calculated and compared between benign and malignant lesions and among different histologic subgroups which included three or more cases. There was a statistically significant difference in SUV between benign (1.80±1.42 [SD]) and malignant (4.20±3.16) soft tissue masses in total (P<0.0001). However, a considerable overlap in SUV was observed between many benign and malignant lesions. Liposarcomas (2.16±1.72) and synovial sarcomas (1.60±0.43) did not show significantly higher SUV than any benign lesions. Metastases (4.23±2.35) showed no statistically significant difference in SUV as compared with schwannomas (1.75±0.84), desmoids (2.77±1.32), sarcoidosis (3.62±1.53), or giant cell tumors of tendon sheath (GCT of TS; 5.06±1.63). Even malignant fibrous histiocytomas (5.37±1.40) could not be differentiated from sarcoidosis or GCT of TS, based on the SUV. A large accumulation of FDG can be observed in both benign and malignant histiocytic, fibroblastic, or neurogenic lesions. SUV at conventional FDG-PET is limited to differentiating benign from malignant soft tissue masses, when all kinds of histologic subtypes are included. (orig.)

2003-03-01

149

Maxillofacial fibrous dysplasia  

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Full Text Available Fibrous dysplasia is a non- neoplastic hamartomatous developmental fibro osseous lesion of bone. This paper provides a brief overview of fibrous dysplasia in a historic perspective and highlights the controversies in fibrous dysplasia seen in the cranio- maxillofacial lesions. A case report of a young woman is presented who was diagnosed as having maxillofacial fibrous dysplasia, thereby making an attempt to use this term in cases with relatively limited facial bone disease.

Mahajan Sumita

2005-01-01

150

Vena cava replacement for malignant disease: is there a role?  

Science.gov (United States)

Resection and graft replacement of the vena cava for malignant disease is rarely performed, often because of the advanced tumor stage. Since August 1987 we have selectively performed caval replacement in conjunction with tumor resection in 11 patients. Three patients had superior vena cava reconstruction (SVCR) and eight had inferior vena cava replacement (IVCR). There were six males and five females whose mean age was 59.3 years (range 24 to 75 years). Two patients, each with superior vena cava obstruction, presented with symptoms from venous compression. Malignancies involving the superior vena cava were thyroid carcinoma in two patients and lymphoma in one. Cancers requiring IVCR were leiomyosarcoma in three patients, cholangiocarcinoma in two, and malignant fibrous histiocytoma, hepatocellular carcinoma, and colon carcinoma metastatic to the liver in one each. All IVCRs and two SVCRs were performed with expanded polytetrafluoroethylene grafts. The remaining SVCR was constructed with spiral saphenous vein. Six IVCRs involved replacement of the retrohepatic inferior vena cava in conjunction with major liver resection. Mean intraoperative blood transfusions were 5.3 units (range 0 to 10 units). There were no operative deaths. Complications occurred in four patients and included postoperative bleeding in two, myocardial infarction in one, and wound infection in one. There were no perioperative graft occlusions, but one patient developed graft occlusion 2 months after SVCR. All IVCR grafts have remained patent (mean follow-up of 8.8 months). Two patients with SVCRs have died from recurrent cancer at 3.2 and 3.4 years postoperatively. Six patients with IVCRs have developed tumor recurrence either locally (n = 1), at a distant site (n = 2), or both (n = 3). Importantly, eight of nine survivors have an excellent performance status. We conclude that vena cava reconstruction for malignancy can be performed safely, has few graft-related complications, and in some patients may offer the only possibility for tumor control. PMID:8518120

Bower, T C; Nagorney, D M; Toomey, B J; Gloviczki, P; Pairolero, P C; Hallett, J W; Cherry, K J

1993-01-01

151

Stereotactic radiosurgery for primary malignant spinal tumors.  

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Objectives: We adopted stereotactic radiosurgery (SRS) to treat primary malignant spinal tumors. The objective of this study was to evaluate local control rate and to identify prognostic factors after SRS for primary malignant spinal tumors. Methods: Medical records and radiological data for 29 patients with primary malignant spinal tumors were retrospectively analyzed. The histological diagnoses were chordoma (11 cases), chondrosarcoma (5 cases), osteosarcoma (3 cases), synovial sarcoma (3 cases), plasmacytoma (2 cases), Ewing sarcoma (2 cases), malignant peripheral nerve sheath tumor (2 cases), and malignant fibrous histiocytoma (1 case). Patient age ranged from 11 to 68 years (median, 46 years). Surgical resection and percutaneous biopsy were chosen as initial treatments in 25 and 4 cases, respectively. Stereotactic radiosurgery was used as primary treatment method in 14 cases and as a salvage treatment for progressed lesions in 15 cases. Distant metastasis was noted in two sarcoma patients. Eleven patients had undergone previous conventional external beam radiation therapy (cEBRT) before SRS. Overall survival, local progression-free survival, and the prognostic factors affecting local recurrence were investigated. Results: Tumor volume ranged from 2·0 to 235 cc (median, 14 cc). Delivered radiation doses were from 12 to 50 Gy with two to six sessions. The mean radiation dose converted into a biological effective dose (BED) was 60 Gy (range, 43-105 Gy). The mean follow-up period was 50 months (range, 8-126 months). The mean overall survival was 84 months for chordoma patients and 104 months for sarcoma patients. No factors that affected overall survival were found. The mean local progression-free survival was 56 months for chordoma patients and 73 months for sarcoma patients. The recurrent mode of presentation was predictive of local progression of spinal sarcomas (P ?=? 0·009). However, in chordoma patients, no factors were found to correlate with local recurrence. Conclusion: These preliminary results suggest that SRS could provide good local control when applied as postoperative adjuvant or salvage treatment after cEBRT for primary malignant spinal tumors. PMID:24773479

Chang, Ung-Kyu; Lee, Dong Han; Kim, Mi-Sook

2014-06-01

152

Fibrous variant of rhinophyma  

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Rhinophyma is a rare disease which causes disfiguring soft tissue hypertrophy of the nose. The fibrous variant of rhinophyma is still rare which mimics fibrous papule of nose and lupus pernio. We report an unusual fibrous variant which was surgically managed with the good results. The use of scalpel for sculpting and the use of split thickness skin graft is being highlighted.

Mathur, N. N.; Kumar, Sandeep; Bothra, Rajendra; Dhawan, Rajiv; Gudwani, Sanjay; Choudhury, M.

2003-01-01

153

Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature / Tumor fibroso solitário maligno da tiroide: relato de caso e revisão da literatura  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese O tumor fibroso solitário (SFT) é uma neoplasia rara de células fusiformes que mais frequentemente envolve a pleura, raramente ocorrendo em áreas extratorácicas. Já foram descritos 26 casos de SFT da tiroide. Relatamos o caso de uma paciente de 60 anos de idade com um histórico de 8 meses de aumento [...] do pescoço associado à disfagia. A paciente foi submetida a uma hemitiroidectomia direita e foi diagnosticado um SFT de tiroide. A imuno-histoquímica mostrou resultados positivos para o marcador CD34, e o grande número de mitoses e a presença de atipia celular sugerem que o tumor era maligno. Em nosso conhecimento, este é o segundo caso de STF da tiroide maligno já relatado. Dada a rara ocorrência desses tumores, a indicação de tratamento adjuvante e o prognóstico são incertos. Recomenda-se o acompanhamento de longo prazo depois da ressecção cirúrgica. Abstract in english Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm that most often involves the pleura, rarely occurring in extra-thoracic locations. Twenty-six cases of SFT arising in the thyroid gland have been described. We report a case of a 60-year-old woman presenting an 8-month history of enla [...] rgement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisable.

Wellington, Alves Filho; Renata Regina da Graça Lorencetti, Mahmoud; Daniel Marin, Ramos; Vergilius José Furtado de, Araujo-Filho; Patricia Picciarelli de, Lima; Claudio Roberto, Cernea; Lenine Garcia, Brandão.

154

Fibrous dysplasia of bone: a clinicopathologic review  

Directory of Open Access Journals (Sweden)

Full Text Available Harsh Mohan1, Preeti Mittal1, Irneet Mundi1, Sudhir Kumar21Department of Pathology, 2Department of Orthopedics, Government Medical College, Sector 32, Chandigarh, IndiaAbstract: Fibrous dysplasia of the bones is an uncommon congenital skeletal disorder that is found equally in both genders and is not inherited. Its etiology has been linked to an activating mutation of Gs? and the downstream effects of the resultant increase in cAMP. Fibrous dysplasia is categorized as either monostotic or polyostotic, and may occur as a component of McCune-Albright syndrome or the rare Mazabraud syndrome. Long bones, skull bones, and ribs are the most commonly affected bones. The radiological picture is somewhat variable, including a ground-glass appearance, expansion of the bone, and sclerosis surrounding the lesion. Histologically, fibrous dysplasia shows irregularly-shaped trabeculae of immature, woven bone in a background of variably cellular, loosely arranged fibrous stroma. It may be complicated by pathologic fracture, and rarely by malignant transformation. This review examines interesting issues surrounding the etiology of fibrous dysplasia, its clinical and laboratory manifestations, radiological picture, utility of bone biopsy, gross and microscopic pathology, complications, and its differential diagnostic considerations.Keywords: fibrous dysplasia, McCune-Albright syndrome, monostotic form, polyostotic form

Mohan H

2011-11-01

155

Fibrous Hamartoma of Infancy.  

Science.gov (United States)

The pathologic and clinical features of 30 cases of a distinctive fibrous tumor occurring in infants were analyzed. Characteristically, the tumor showed a prevalence for the male sex and affected principally the subcutaneous tissue of the axilla, shoulder...

F. M. Enzinger

1964-01-01

156

Steel Fibrous Concrete  

International Science & Technology Center (ISTC)

The Construction of Reliable and Durable Structural Units for Energy Facilities, Transportation Facilities and Other Structures Subjected to the Action of a Variety of Conditions and Loads Using New Compound Material - Steel Fibrous Concrete

157

Complementary scintigraphy in polyostotic fibrous dysplasia  

Energy Technology Data Exchange (ETDEWEB)

A 65-year-old man with a long history of right knee pain complained of discomfort in both hips. An X-ray has identified changes in the pelvis to indicate Paget`s disease. Bone scintigraphy after administration of thallium-201 was performed to ascertain the extent of this disorder. The whole body sweep showed multiple areas of abnormal uptake of varying size and intensity. This finding excluded the possibility of malignant change such as osteogenic sarcoma and malignant fibrous hystiocytoma . 2 figs.

Murray, I.P.C.; Haindl, W.; Frater, C.J. [Nuclear Diagnostics Randwick, NSW (Australia)

1996-09-01

158

Strength of Fibrous Composites  

CERN Document Server

"Strength of Fibrous Composites" addresses evaluation of the strength of a fibrous composite by using its constituent material properties and its fiber architecture parameters. Having gone through the book, a reader is able to predict the progressive failure behavior and ultimate strength of a fibrous laminate subjected to an arbitrary load condition in terms of the constituent fiber and matrix properties, as well as fiber geometric parameters. The book is useful to researchers and engineers working on design and analysis for composite materials. Dr. Zheng-Ming Huang is a professor at the School of Aerospace Engineering & Applied Mechanics, Tongji University, China. Mr. Ye-Xin Zhou is a PhD candidate at the Department of Mechanical Engineering, the University of Hong Kong, China.

Huang, Zheng-Ming

2012-01-01

159

A case of congenital solitary Langerhans cell histiocytoma.  

LENUS (Irish Health Repository)

A newborn baby boy was referred to the Paediatric Dermatology Unit with a solitary asymptomatic nodule overlying his right nasolabial fold. Complete physical examination, full blood count, serum chemistry, liver function tests and baseline imaging were unremarkable. Histopathological examination showed an atypical dermal infiltrate of mononuclear cells that stained positive with CD1a and S100. A diagnosis of congenital solitary Langerhans cell histiocytoma was made. The lesion completely resolved by 4 months of age. The baby is now 15 months old and repeat systemic evaluation has remained normal.

Ricciardo, Bernadette

2012-02-01

160

Development of a sarcoma in a surgical scar.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The development of a malignant soft tissue tumour (malignant fibrous histiocytoma) in a surgical wound is reported. Although rare, this occurrence has important diagnostic implications and the management is discussed.

Sherlock, D. J.; Rickards, H.; Gardecki, T. I.; Hamer, J. D.

1987-01-01

 
 
 
 
161

A case of multiple primary malignancies and investigation of family history.  

Science.gov (United States)

The occurrence of multiple primary malignancies (MPM) in one patient is a rare but increasingly frequent event, partly due to medical advances in diagnosis and therapy. A number of theories have been proposed to explain MPM, but none have been proven. A key risk factor appears to be family history. We present the case of a 43-year-old male with multiple cancers who was first admitted to the hospital for an undifferentiated pleomorphic sarcoma/pleomorphic malignant fibrous histiocytoma (pG2T2bN0Mx stage III) of the right scapula in May 2009. The patient underwent three tumor resections in situ due to tumor recurrence. During the period of chemotherapy and radiotherapy, computed tomography (CT) revealed a 10x10-cm enhancing soft mass of the ascending colon, which was diagnosed as mucinous adenocarcinoma in a pathological report. Laboratory data showed elevated serum levels of carcinoembryonic antigen (CEA, 20.0 ?g/l; normal range, 0.0-10.0 ?g/l). Certain family members of the patient had been diagnosed with endometrial, colon and pancreatic cancer. None of the family had a smoking history or presented with familial adenomatous polyposis (FAP). The patient with hereditary non-polyposis colorectal cancer (HNPCC), whose family fulfilled Amsterdam Criteria I (AC I), has remained free of disease for 15 months. Family history may be a key risk factor for MPM and HNPCC, the detailed molecular mechanisms of which remain to be elucidated. This case report with an investigation of family history may improve the clinical recognition of HNPCC and MPM. PMID:23162625

Huang, Xiu-Yan; Huang, Zi-Li; Huang, Jin; Wang, Zhi-Gang; Zheng, Qi

2012-11-01

162

Failure mechanisms in fibrous scaffolds.  

Science.gov (United States)

Polymeric fibrous scaffolds have been considered as replacements for load-bearing soft tissues, because of their ability to mimic the microstructure of natural tissues. Poor toughness of fibrous materials results in failure, which is an issue of importance to both engineering and medical practice. The toughness of fibrous materials depends on the ability of the microstructure to develop toughening mechanisms. However, such toughening mechanisms are still not well understood, because the detailed evolution at the microscopic level is difficult to visualize. A novel and simple method was developed, namely, a sample-taping technique, to examine the detailed failure mechanisms of fibrous microstructures. This technique was compared with in situ fracture testing by scanning electron microscopy. Examination of three types of fibrous networks showed that two different failure modes occurred in fibrous scaffolds. For brittle cracking in gelatin electrospun scaffolds, the random network morphology around the crack tip remained during crack propagation. For ductile failure in polycaprolactone electrospun scaffolds and nonwoven fabrics, the random network deformed via fiber rearrangement, and a large number of fiber bundles formed across the region in front of the notch tip. These fiber bundles not only accommodated mechanical strain, but also resisted crack propagation and thus toughened the fibrous scaffolds. Such understanding provides insight for the production of fibrous materials with enhanced toughness. PMID:23470550

Koh, C T; Strange, D G T; Tonsomboon, K; Oyen, M L

2013-07-01

163

Fibrous Pseudotumour of the Testis  

Directory of Open Access Journals (Sweden)

Full Text Available Fibrous pseudotumour of the testis is a rare benign lesion involving the paratesticular region. It usually presents in nodular form and may cause diagnostic dilemma resulting in unnecessary sacrifice of the testes. We report a rare case of diffuse fibrous pseudotumour which had to be treated by orchiectomy. [J Interdiscipl Histopathol 2013; 1(4.000: 227-229

Geetha Vasudevan

2013-08-01

164

Cancer of the Bone and Joint  

Science.gov (United States)

... More Cancer and the Bone and Joint Primary bone cancer is cancer that forms in cells of the bone. Some types of primary bone cancer are osteosarcoma, Ewing sarcoma, malignant fibrous histiocytoma, and ...

165

Gluteal Congenital Fibrous Hamartoma of Infancy: A Case Report  

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Fibrous hamartoma of infancy (FHI) is a rare benign subcutaneous tumor which is commonly seen in the first year of life. Patients usually present with a single, painless, rapidly growing mass located mostly on the upper extremities. It can be difficult to distinguish this lesion from the malignant soft tissue sarcomas because of the rapid growth and radiological characteristics. Here we report a 5-month-old boy with a large gluteal mass and cutaneous findings which was initially thought to be...

Begul Yagci-Kupeli; Arbay Ozden Ciftci; Bilgehan Yalcin; Mithat Haliloglu; Zuhal Akcoren; Munevver Buyukpamukcu

2013-01-01

166

Intraarterial Chemotherapy for Extremity Osteosarcoma and MFH in Adults  

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The neoadjuvant treatment of osteosarcoma using intravenous agents has resulted in survival rates of 55% to 77% [3, 5, 6, 20, 22, 35]. We designed a neoadjuvant chemotherapy protocol using combined intraarterial and intravenous agents to treat high-grade osteosarcoma and malignant fibrous histiocytoma of bone in an attempt to improve survival. We report the results of treating 53 adults (age 18–77 years) diagnosed with nonmetastatic extremity osteosarcoma or malignant fibrous histiocytoma....

Hugate, Ronald R.; Wilkins, Ross M.; Kelly, Cynthia M.; Madsen, Walt; Hinshaw, Ioana; Camozzi, Anne B.

2008-01-01

167

Aneurysmal bone cyst in association with fibrous dysplasia. A case report.  

Science.gov (United States)

A patient with polyostotic fibrous dysplasia had several fractures of the right lower limb. An above-knee amputation was eventually performed, followed by arthrodesis of the hip. Five years later the stump became painful and swelled with dramatic rapidity. Biopsy showed that this was not due to malignant change, but that an aneurysmal bone cyst had developed in association with the fibrous dysplasia. PMID:3941131

Diercks, R L; Sauter, A J; Mallens, W M

1986-01-01

168

Malignant pleural disease  

International Nuclear Information System (INIS)

The vast majority of pleural neoplasms invade the pleura secondarily and can be seen in patients with bronchogenic carcinoma, breast cancer, lymphoma, and ovarian or gastric carcinoma. Primary pleural neoplasms are less common, although they have developed notoriety since the up-surge of malignant mesothelioma and the knowledge of its connection to asbestos exposure. Other malignant primary tumors include localized fibrous tumor and pleural liposarcoma. In most patients with diffuse malignant pleural disease the chest radiograph shows pleural effusion with or without pleural thickening. Computed tomography (CT) usually provides precise localization and extent of the disease and may be of value in assessing chest wall and mediastinal involvement. In specific situations, magnetic resonance (MR) may be useful as a problem-solving tool when CT findings of chest wall or diaphragmatic invasion are equivocal or in patients with contraindication to intravenous administration of ionic contrast material

2000-05-01

169

Malignant pleural disease  

Energy Technology Data Exchange (ETDEWEB)

The vast majority of pleural neoplasms invade the pleura secondarily and can be seen in patients with bronchogenic carcinoma, breast cancer, lymphoma, and ovarian or gastric carcinoma. Primary pleural neoplasms are less common, although they have developed notoriety since the up-surge of malignant mesothelioma and the knowledge of its connection to asbestos exposure. Other malignant primary tumors include localized fibrous tumor and pleural liposarcoma. In most patients with diffuse malignant pleural disease the chest radiograph shows pleural effusion with or without pleural thickening. Computed tomography (CT) usually provides precise localization and extent of the disease and may be of value in assessing chest wall and mediastinal involvement. In specific situations, magnetic resonance (MR) may be useful as a problem-solving tool when CT findings of chest wall or diaphragmatic invasion are equivocal or in patients with contraindication to intravenous administration of ionic contrast material.

Bonomo, Lorenzo E-mail: l.bonomo@radiol.unich.it; Feragalli, Beatrice; Sacco, Rocco; Merlino, Biagio; Storto, Maria Luigia

2000-05-01

170

Malignant pleural disease.  

Science.gov (United States)

The vast majority of pleural neoplasms invade the pleura secondarily and can be seen in patients with bronchogenic carcinoma, breast cancer, lymphoma, and ovarian or gastric carcinoma. Primary pleural neoplasms are less common, although they have developed notoriety since the up-surge of malignant mesothelioma and the knowledge of its connection to asbestos exposure. Other malignant primary tumors include localized fibrous tumor and pleural liposarcoma. In most patients with diffuse malignant pleural disease the chest radiograph shows pleural effusion with or without pleural thickening. Computed tomography (CT) usually provides precise localization and extent of the disease and may be of value in assessing chest wall and mediastinal involvement. In specific situations, magnetic resonance (MR) may be useful as a problem-solving tool when CT findings of chest wall or diaphragmatic invasion are equivocal or in patients with contraindication to intravenous administration of ionic contrast material. PMID:10874176

Bonomo, L; Feragalli, B; Sacco, R; Merlino, B; Storto, M L

2000-05-01

171

Clinical guidelines for the management of craniofacial fibrous dysplasia  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Fibrous dysplasia (FD is a non-malignant condition caused by post-zygotic, activating mutations of the GNAS gene that results in inhibition of the differentiation and proliferation of bone-forming stromal cells and leads to the replacement of normal bone and marrow by fibrous tissue and woven bone. The phenotype is variable and may be isolated to a single skeletal site or multiple sites and sometimes is associated with extraskeletal manifestations in the skin and/or endocrine organs (McCune-Albright syndrome. The clinical behavior and progression of FD may also vary, thereby making the management of this condition difficult with few established clinical guidelines. This paper provides a clinically-focused comprehensive description of craniofacial FD, its natural progression, the components of the diagnostic evaluation and the multi-disciplinary management, and considerations for future research.

Lee JS

2012-05-01

172

Spinal polyostotic fibrous dysplasia in two adults: Does only biopsy unravel the mystery?  

Science.gov (United States)

Polyostotic fibrous dysplasia is a rare non-inheritable genetic disease due to mutation in GNAS gene. Here we present two adults who were accidentally detected lytic lesions in spine and after extensive evaluation for malignancies; was diagnosed on biopsy. Current concept of the disease and management is discussed. PMID:24381894

Gundgurthi, Abhay; Garg, M K; Bhardwaj, Reena; Kharb, Sandeep; Pandit, Aditi; Brar, Karninder S; Kumar, Ravi; Pandit, A G

2013-11-01

173

Generalized Eruptive Histiocytomas and Rosai-Dorfman Disease Presenting Concurrently in a Patient with Myelodysplastic Syndrome  

Science.gov (United States)

Non-Langerhans cell histiocytoses were originally described as individual diagnoses. However, evidence has been mounting that these entities are manifestations on a spectrum of the same disease. The authors present a patient who initially presented with lymphadenopathy, pancytopenia, splenomegaly, and high-grade fevers. A bone marrow biopsy was performed and she was diagnosed with myelodysplastic syndrome with trisomy 8. Several months later, her persistent pulmonary lymphadenopathy was biopsied revealing Rosai-Dorfman disease. Two years after her initial hospitalization, the patient presented with lesions consistent with generalized eruptive histiocytomas. This case highlights the difficulty that clinicians encounter when trying to separate generalized eruptive histiocytomas, Rosai-Dorfman disease, and the other non-Langerhans cell histiocytoses. While further research needs to be performed in the field of histiocytoses, this case provides clinical support that these diseases are closely linked.

Darabi, Kamruz; Peters, Sara; Peters, Sara; Kynyk, Jessica; Bechtel, Mark

2012-01-01

174

Fibrous metaphyseal defect (fibrous cortical defect, non-ossifying fibroma)  

International Nuclear Information System (INIS)

Fibrous cortical defect and nonossifying fibromas can be classified together as fibrous metaphyseal defects (FMD) since they have the same pahtological substrate, with a tendency to the same localisation around the knee, and occuring at the same age. They have a tendency to spontaneous healing, are clinically silent and are usually discovered accidentally during radiological examination. A radiological survey fo 5.674 metaphyseal regions in the upper and lower extremities of 2.065 unselected patients aged one to 20 years revealed an incidence of 1.8%; exlcusive examination of the distal femur showed an incidence of 2.7%. 96% of all lesions were in the lower extremities and only 4% in the upper. The marked discrepancy in the incidence rate between American and German publications is discussed. (orig.)

1981-01-01

175

Denosumab Treatment for Fibrous Dysplasia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fibrous dysplasia (FD) is a skeletal disease caused by somatic activating mutations of the cAMP-regulating protein, Gs?. These mutations lead to replacement of normal bone by proliferative osteogenic precursors, resulting in deformity, fracture, and pain. Medical treatment has been ineffective in altering the disease course. RANK ligand (RANKL) is a cell surface protein involved in many cellular processes, including osteoclastogenesis, and is reported to be overexpressed in FD-like bone cell...

2012-01-01

176

Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma  

Science.gov (United States)

Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Childhood Alveolar Soft-part Sarcoma; Childhood Angiosarcoma; Childhood Epithelioid Sarcoma; Childhood Fibrosarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Mesenchymoma; Childhood Neurofibrosarcoma; Childhood Synovial Sarcoma; Chondrosarcoma; Dermatofibrosarcoma Protuberans; Localized Childhood Malignant Fibrous Histiocytoma of Bone; Metastatic Childhood Malignant Fibrous Histiocytoma of Bone; Metastatic Childhood Soft Tissue Sarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Stage I Adult Soft Tissue Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

2013-06-14

177

Primary malignant liver mesenchymal tumor: A case report  

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Primary malignant liver mesenchymal tumor is a rare condition defined as a tumor with vascular, fibrous, adipose, and other mesenchymal tissue differentiation. We report a case of primary malignant liver mesenchymal tumor in a 51-year-old male with anemia, weight loss and hepatomegaly. Finally unconventional liver biopsy and histological manifestation led to the definitive diagnosis.

2010-01-01

178

Primary malignant liver mesenchymal tumor: A case report  

Directory of Open Access Journals (Sweden)

Full Text Available Primary malignant liver mesenchymal tumor is a rare condition defined as a tumor with vascular, fibrous, adipose, and other mesenchymal tissue differentiation. We report a case of primary malignant liver mesenchymal tumor in a 51-year-old male with anemia, weight loss and hepatomegaly. Finally unconventional liver biopsy and histological manifestation led to the definitive diagnosis.

Jing Chen, Ya-Ju Du, Ji-Tao Song, Lin-Ning E, Bing-Rong Liu

2010-11-01

179

Localized fibrous mesothelioma of the pleura: Radiographic findings in 60 cases  

International Nuclear Information System (INIS)

Localized fibrous mesothelioma (solitary fibrous tumor of the pleura) is a rare plasm that originates from subpleural connective tissue and has a significant malignant potential. In a radiographic review of 60 cases, the tumor typically appeared as an extraparenchymal mass with sharply rounded or lobulated margins. Two thirds were more than 5 cm in diameter, but in only one case was pulmonary invasion suggested. Effusions were small and uncommon. CT usually showed a homogenous soft-tissue mass. Calcification was uncommon. After resection, seven tumors recurred locally, two of them after more than 5 years. Accordingly, close and prolonged follow-up is recommended

1986-12-05

180

Giant solitary fibrous tumor of the epicardium causing reversible heart failure.  

Science.gov (United States)

A 68-year-old woman with a 2-year history of dyspnea and fatigue was admitted to our hospital with a massive pericardial effusion. Computed tomography and cardiovascular magnetic resonance imaging revealed a huge (17 cm maximum diameter) intrapericardial mass. After successful tumor resection, a giant solitary fibrous tumour of the epicardium was diagnosed by histology. Histologic features of malignancy were absent, and the patient is alive and well 1 year after the operation, undergoing close follow-up at regular intervals. Recurrences have been exceptionally reported in benign solitary fibrous tumors, and experience with this exceptionally rare and enigmatic cardiac tumor is lacking. PMID:23910146

Bianchi, Giacomo; Ferrarini, Matteo; Matteucci, Marco; Monteleone, Angelo; Aquaro, Giovanni Donato; Passino, Claudio; Pucci, Angela; Glauber, Mattia

2013-08-01

 
 
 
 
181

Optic Nerve Decompression for Orbitofrontal Fibrous Dysplasia  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Orbitofrontal fibrous dysplasia often involves the bony orbit and the optic canal. Although fibrous dysplasia reportedly produces compression of the optic nerve leading to visual distrubances, optic nerve decompression in patients without clinical signs of optic neuropathy is still controversial. We describe two patients with orbitofrontal fibrous dysplasia without signs of visual disturbance and one patient with McCune-Albright syndrome and progressive visual impairment. Optic nerve decompre...

Abe, Takumi; Sato, Kaneshige; Otsuka, Takaharu; Kawamura, Noriyoshi; Shimazu, Motohiko; Izumiyama, Hitoshi; Matsumoto, Kiyoshi

2002-01-01

182

Fracture toughness in fibrous materials  

CERN Multimedia

In the present paper, a fiber bundle model in (1+1)-dimensions that simulates the rupture process of a fibrous material pulled by an uniaxial force F is analyzed. In this model the load of a broken fiber is shifted in equal portions onto the nearest unbroken fibers. The force-displacement diagram is obtained for several traction velocities v and temperatures t. Also, it is shown how the fracture toughness $K_c$ changes with the traction velocity v and with the temperature t. In this paper it is shown that the rupture process is strongly dependent on temperature t and on velocity v.

Menezes-Sobrinho, I L

2001-01-01

183

Quantification of the magnetization-transfer contrast effect: can it yield additional information in differentiation of musculoskeletal lesions particularly in separation of benign from malignant lesions; Quantifizierung des Magnetization Transfer Contrast (MTC) Effektes durch Berechnung von MT-Quotienten: Ergeben sich Zusatzinformationen fuer die Differenzierung benigner und maligner Erkrankungen des Bewegungsapparates?  

Energy Technology Data Exchange (ETDEWEB)

Purpose: To investigate the potential information of the amount of magnetization-transfer effect in musculoskeletal lesions and to compare MT ratios from benign and malignant musculoskeletal lesions. Material and Method: 49 patients with malignant tumors (3 osteosarcoma, 3 malignant fibrous histiocytoma, 4 chondrosarcoma, 2 Ewing sarcomas) and benign lesions (8 chondroma, 2 fibrous dysplasia, 3 osteoid-osteoma, 6 ganglion cyst, 3 cyst, 3 osteomyelitis, 4 tendinitis, 3 rotator cuff tear, 5 scar tissue) were scanned using routine MRI protocols including T{sub 1}- and T{sub 2}-weighted spin echo as well as T{sub 2}*-weighted gradient echo (FFE) sequences at 1.5 Tesla (ACS II, Philips Medical). Additionally MTC images were generated by combining the FFE sequence and the off-resonance MT technique (-1500 Hz off-resonance frequency, 1770 flip angle and 50 ms pulse duration). MT ratios were calculated as SI{sub o}-SI{sub m}/SI{sub o}. Results: The MT ratio of benign lesions was 26{+-}15%, that of malignant lesions was 22{+-}6%. The difference was statistically not significant. As expected muscle showed a high MT ratio of 50{+-}8%. Scar tissue demonstrated an MT ratio of 39{+-}16% which was significantly higher than the tumor MT ratios. Conclusion: MTC (MT ratios) failed to show significant differences between benign and malignant lesions as was expected due to basic differences in cellularity, rate of mitosis and chromatin content. MTC might however gain more importance in separating scar tissue from recurrent tumor in the future. (orig.) [German] Zielsetzung: Durch die Quantifizierung des Magnetization Transfer Contrastes sollte untersucht werden, ob sich Zusatzinformationen in der Magnetresonanztomographie des Stuetz- und Bewegungsapparates ergeben. Insbesondere sollte ermittelt werden, ob gut- und boesartige Laesionen unterschiedliche MT-Quotienten aufweisen. Material und Methode: 49 Patienten mit boesartigen Tumoren (3 Osteosarkom, 4 Chondrosarkom, 3 Malignes Fibroeses Histiozytom, 2 Ewing-Sarkom) and gutartigen Erkrankungen (8 Chondrom, 2 Fibroese Dysplasie, 3 Osteoid-Osteom, 6 Ganglion, 3 Zysten, 3 Osteomyelitis, 4 Tendinitis, 3 Rotatorenmanschettenruptur, 5 Narbengewebe) wurden mit herkoemmlicher MRT sowie resonanz-frequenzferner MTC-Methode (-1500 Hz Resonanzverschiebung, 50 ms Pulslaenge, 1770 MT-Pulswinkel) bei 1,5 Tesla (ACS II, Philips Medizinsysteme) untersucht. Der MTC-Effekt wurde durch Berechnung des MT-Quotienten (MT-ratio) quantifiziert. Ergebnisse: Der MT-Quotient gutartiger Laesionen lag im Mittel gering ueber dem maligner Laesionen (26{+-}15% versus 22{+-}6%). Der Unterschied war statistisch nicht signifikant. Narbengewebe wies einen signifikant hoeheren MT-Quotienten (39{+-}16%) als Tumoren auf. Schlussfolgerung: Die Berechnung des MT-Quotienten ist nicht geeignet, um gutartige von boesartigen Erkrankungen des Stuetz- und Bewegungsapparates zu unterscheiden. Zur Differenzierung von Narbengewebe gegenueber Tumorrezidiv koennte MTC einen Stellenwert erlangen. (orig.)

Vahlensieck, M.; Traeber, F.; Schild, H. [Radiologische Universitaetsklinik Bonn (Germany); Gieseke, J. [Philips Medizinsysteme (Germany)

1999-12-01

184

Oral focal fibrous hyperplasia and squamous cell papilloma treated with an erbium laser. Case presentation.  

Science.gov (United States)

Mouth and oropharynx cancer constitute 5% of all malignancies; 95% of them are head and neck squamous cell carcinomas. Carcinogenesis is a multifactor process. Mutagenesis is also determined by the human papilloma virus which has recently been found to be etiologically associated with 20 to 25% of head and neck squamous cell carcinomas, mostly in the oropharinx. Focal fibrous hyperplasia of the connective tissue comes up as an answer to a chronic irritation in which a big amount of collagen can be found. As there exist certain clinical resemblance between squamous cell papilloma, fibrous focal hyperplasia and other mesenchimal tumors it is recommended to proceed, always, with removal and study. Two cases, one of an oral papilloma and another of a focal fibrous hyperplasia in pediatric patients, treated with an Er,Cr:YSGG laser wave length (mu) of 2780 nm are presented. PMID:24654496

Boj, J; Hernandez, M; Espasa, E; Espanya, A

2014-01-01

185

Pazopanib Hydrochloride Followed By Chemotherapy and Surgery in Treating Patients With Soft Tissue Sarcoma  

Science.gov (United States)

Adult Angiosarcoma; Adult Desmoplastic Small Round Cell Tumor; Adult Epithelioid Hemangioendothelioma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Dermatofibrosarcoma Protuberans; Stage IIA Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

2014-01-29

186

CT findings of craniofacial fibrous dysplasia  

Energy Technology Data Exchange (ETDEWEB)

Fibrous dysplasia is a benign bony disorder that contains trabeculae of poorly calcified primitive bone formed by osseous metaplasia. It is also characterized by replacement of normal spongiosa by abnormal fibrous tissues. We retrospectively analyzed the computed tomographic (CT) findings of 29 cases with clinically and radiologically diagnosed craniofacial fibrous dysplasia. In 2 cases, only cranial bones were involved and in 7 cases only facial bones were involved. Involvements of both cranial and facial bones were noted in the remained 20 cases. The commonly involved bones in the decreasing order of frequency were as follows: frontal, sphenoidal, ethmoidal and temporal bones in cranium and maxilla, zygoma, lacrimal bones and mandible in facial bones. Even though plain films are enough to diagnose the fibrous dysplasia, we think that CT is useful in more accurate diagnosis by demonstrating amorphous 'ground-glass' appearance in the lesion and defining the exact extent of craniofacial fibrous dysplasia.

Lee, Seong Suk; Lee, Ghi Jai; Jung, Myung Seok; Kim, Yong Soo; Kim, Ho Kyun; Han, Chang Yul [Inje University College of Medicine, Pusan (Korea, Republic of)

1993-11-15

187

Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma  

Science.gov (United States)

Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Desmoplastic Small Round Cell Tumor; Adult Epithelioid Hemangioendothelioma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Rhabdomyosarcoma; Adult Synovial Sarcoma; Chondrosarcoma; Clear Cell Sarcoma of the Kidney; Conjunctival Kaposi Sarcoma; Dermatofibrosarcoma Protuberans; Gastrointestinal Stromal Tumor; Metastatic Adult Malignant Fibrous Histiocytoma of Bone; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Osteosarcoma; Ovarian Sarcoma; Recurrent Adult Malignant Fibrous Histiocytoma of Bone; Recurrent Adult Soft Tissue Sarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Kaposi Sarcoma; Recurrent Osteosarcoma; Recurrent Uterine Sarcoma; Small Intestine Leiomyosarcoma; Stage III Adult Soft Tissue Sarcoma; Stage III Uterine Sarcoma; Stage IV Adult Soft Tissue Sarcoma; Stage IV Uterine Sarcoma

2014-06-02

188

Fibrous-Ceramic/Aerogel Composite Insulating Tiles  

Science.gov (United States)

Fibrous-ceramic/aerogel composite tiles have been invented to afford combinations of thermal-insulation and mechanical properties superior to those attainable by making tiles of fibrous ceramics alone or aerogels alone. These lightweight tiles can be tailored to a variety of applications that range from insulating cryogenic tanks to protecting spacecraft against re-entry heating. The advantages and disadvantages of fibrous ceramics and aerogels can be summarized as follows: Tiles made of ceramic fibers are known for mechanical strength, toughness, and machinability. Fibrous ceramic tiles are highly effective as thermal insulators in a vacuum. However, undesirably, the porosity of these materials makes them permeable by gases, so that in the presence of air or other gases, convection and gas-phase conduction contribute to the effective thermal conductivity of the tiles. Other disadvantages of the porosity and permeability of fibrous ceramic tiles arise because gases (e.g., water vapor or cryogenic gases) can condense in pores. This condensation contributes to weight, and in the case of cryogenic systems, the heat of condensation undesirably adds to the heat flowing to the objects that one seeks to keep cold. Moreover, there is a risk of explosion associated with vaporization of previously condensed gas upon reheating. Aerogels offer low permeability, low density, and low thermal conductivity, but are mechanically fragile. The basic idea of the present invention is to exploit the best features of fibrous ceramic tiles and aerogels. In a composite tile according to the invention, the fibrous ceramic serves as a matrix that mechanically supports the aerogel, while the aerogel serves as a low-conductivity, low-permeability filling that closes what would otherwise be the open pores of the fibrous ceramic. Because the aerogel eliminates or at least suppresses permeation by gas, gas-phase conduction, and convection, the thermal conductivity of such a composite even at normal atmospheric pressure is not much greater than that of the fibrous ceramic alone in a vacuum.

White, Susan M.; Rasky, Daniel J.

2004-01-01

189

Solitary fibrous tumor of the pleura presenting with syncope episodes when coughing  

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Abstract Background Solitary fibrous tumor of the pleura is a rarely encountered clinical entity which may have different clinical pictures. Although the majority of these neoplasms have a benign course, the malignant form has also been reported. Case presentation We herein describe a case of 72 year-old man with head, facial, and thoracic traumas caused by neurally-mediated situational syncope when coughing. The diagnostic work-up including chest x-ray, CT and ...

Santambrogio Luigi; Nosotti Mario; Palleschi Alessandro; Rosso Lorenzo; Tosi Davide; De Simone Matilde; Ciulla Michele M; Maggioni Marco; Cioffi Ugo

2008-01-01

190

Outcome of patients with advanced solitary fibrous tumors: the Centre Léon Bérard experience.  

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BACKGROUND: Solitary Fibrous Tumor is a rare type of soft tissue tumor of intermediate malignant potential which may recur or metastasize in 15-20% of cases. Data on the management of patients with advanced SFT is scarce: chemotherapy has been described as ineffective, while recent data suggests that anti-angiogenic therapies may be more efficient. METHODS: We conducted a retrospective study on patients treated for advanced SFT at a single institution: from January 1994 to December 2011, 30 p...

Levard, Alice; Derbel, Olfa; Me?eus, Pierre; Ranche?re, Dominique; Ray-coquard, Isabelle; Blay, Jean-yves; Cassier, Philippe

2013-01-01

191

Gastric calcifying fibrous tumor removed by endoscopic submucosal dissection  

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Full Text Available The World Health Organization describes calcifying fibrous tumors (CFTs as rare, benign lesions characterized by hypocellular, densely hyalinized collagenization with lymphoplasmacytic infiltration. These tumors rarely involve the gastrointestinal (GI tract. A routine endoscopic upper gastrointestinal screen detected a 10-mm submucosal tumor (SMT in the lesser curvature of the lower corpus of the stomach of an apparently healthy, 37-year-old woman with no history of Helicobacter pylori infection. Endoscopic ultrasonography (EUS localized the internally isoechoic, homogeneous SMT mainly within the submucosa. Malignancy was ruled out using endoscopic submucosal dissection (ESD. A pathological examination confirmed complete resection of the SMT, and defined a hypocellular, spindle-cell tumor with a densely hyalinized, collagenous matrix, scattered lymphoplasmacytic aggregates as well as a few psammomatous, dystrophic calcified foci. The mass was immunohistochemically positive for vimentin and negative for CD117 (c-kit protein, CD34, desmin, smooth muscle actin (SMA and S100. Therefore, the histological findings were characteristic of a CFT. To date, CFT resection by ESD has not been described. This is the first case report of a gastric calcifying fibrous tumor being completely resected by ESD after endoscopic ultrasonography.

Naotaka Ogasawara

2013-01-01

192

Hydromechanical loading and compressibility of fibrous reinforcements  

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During the Resin Film Infusion Process (RFI), the resin flows through the fibrous medium under the stress created by a flexible membrane in the transverse direction of the reinforcement's plane. The compaction of the preforms and the flow of resin through the fibrous network take place simultaneously. There is, therefore, a coupled loading of the porous reinforcements. In order to better control this process, it is necessary to optimize resin pressure and fabric compression by using the appro...

Ouagne, Pierre; Breard, Joel; Ouahbi, Tariq; Park, Chung Hae; Saouab, Abdelghani; Chatel, Sylvain

2008-01-01

193

Haemorrhagic cystic sino-nasal fibrous dysplasia  

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A 9 years old boy reported with left nasal blockage, occasional left nasal bleeding, protruding left eye ball and widening of the nasal bridge for the last nine months. Clinical examination and radiological evaluation were suggeitive of fibrous dysplasia. Mass was excised by transfacial and transcranial approach. Histopathology of the excised muns proved to be a case of haemorrhagic cystic sino-nasal fibrous dysplasia.

Saxena, R. K.; Varshney, Saurabh; Singh, J.; Kaushal, A.; Bishnu, P. P.

2001-01-01

194

Haemorrhagic cystic sino-nasal fibrous dysplasia.  

Science.gov (United States)

A 9 years old boy reported with left nasal blockage, occasional left nasal bleeding, protruding left eye ball and widening of the nasal bridge for the last nine months. Clinical examination and radiological evaluation were suggeitive of fibrous dysplasia. Mass was excised by transfacial and transcranial approach. Histopathology of the excised muns proved to be a case of haemorrhagic cystic sino-nasal fibrous dysplasia. PMID:23119783

Saxena, R K; Varshney, S; Singh, J; Kaushal, A; Bishnu, P P

2001-04-01

195

[Fibrous dysplasia of the clivus: case report].  

Science.gov (United States)

We describe the case of a 43 year-old woman with chronic headache and diplopia. The neuroradiologic exam showed volume increase and alteration in the bone density of the clivus. She was submitted to surgery and the anatomopathologic evidenced fibrous dysplasia. Other 14 of about fibrous dysplasia involving the clivus are related in the literature. We discuss clinical aspects, image exams, histology and treatment of this rare presentation of the disease. PMID:16791381

Falavigna, Asdrubal; Borba, Luis Alencar B; Teles, Alisson Roberto

2006-06-01

196

Antibacterial Properties of Nanosilver PLLA Fibrous Membranes  

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Nanosilver has been studied as a valuable material for it strong antibacterial effects. In this study, we investigated the antibacterial properties of nano silver Poly-L-Lactic acid (Ag/PLLA) composite fibrous membranes. Ag/PLLA fibrous membranes were prepared with silver nanoparticles having weight ratio of silver nanoparticles to PLLA at 5% (w/w). In vitro antibacterial tests were performed using Escherichia coli (E. coli) and Staphylococcus aureus (Staph.) to determine the antibacteri...

2009-01-01

197

Malignant hyperthermia  

International Nuclear Information System (INIS)

Malignant hyperthermia refers to covert myopathies, which do not affect the individual during daily life activities, but may lead to life-threatening tachycardia, rigor, labile blood pressure and most importantly high-grade temperature when exposed to general anesthesia. This conditions is mimicked by thyroid storm, narcoleptic malignant syndrome, phaeochromocytoma and sepsis. We present a presumptive case of malignant hyperthermia. (author)

2004-01-01

198

Malignant mesothelioma  

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Abstract Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium) of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis. The exact prevalence is unknown but it is estimated that mesotheliomas represent less than 1% of all cancers. Its incidence is increasing, with an expected peak in the next 10–20 years. Pleural malignant mesothelioma is the most common form of mesothelioma. Typical pres...

Moore Alastair J; Parker Robert J; Wiggins John

2008-01-01

199

Renal cell carcinoma metastasizing to solitary fibrous tumor of the pleura: a case report  

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Full Text Available Abstract Introduction A tumor metastasizing to another malignancy is an uncommon phenomenon. Since it was first described in 1902, there have been fewer than 200 cases reported in the literature, with lung cancer metastasizing to renal cell carcinoma being the most frequently described pattern. Here we report a case of a solitary fibrous tumor of the lung acting as the recipient for a renal cell carcinoma. To our knowledge, this is the first reported case of such a combination and the second case involving a solitary fibrous tumor. Case presentation A 58-year-old Caucasian man who developed a persistent dry cough presented to our hospital. Imaging studies revealed a large pleural-based mass in the left lung. A biopsy of the mass showed a spindle-cell lesion consistent with a solitary fibrous tumor. The patient underwent surgical excision of the 13 cm mass. The pathological examination confirmed the diagnosis of a solitary fibrous tumor but also demonstrated discrete foci of metastatic renal cell carcinoma. Until that point, a primary renal cell carcinoma tissue diagnosis had not been made and the initial radiological work-up was inconclusive. Conclusion Awareness of the unusual phenomenon of tumor-to-tumor metastasis is important for practicing surgical pathologists, particularly in the evaluation of a mass lesion showing bimodal histology. This case also highlights the importance of careful examination of surgical specimens, as minute and unusual findings can direct patient care.

Wei Shi

2011-06-01

200

Secondary aneurysmal bone cyst in fibrous dysplasia of the proximal femur.  

Science.gov (United States)

Fibrous dysplasia of bone is a congenital skeletal disorder characterized by proliferation of spindle cells inside an intramedullary collagenous stroma and by formation of metaplastic bone. An aneurysmal bone cyst is a lesion of unknown etiology. Macroscopically it appears like a blood-filled cavity that expands the affected bone. Histologically, fibrous septa are bordered by macrophages, giant cells, inflammatory cells, and areas of bone production. Hemorrhagic areas can rise into fibrous dysplasia. The lesion appears as an aggressive and destructive process that is difficult to diagnose properly. A 29-year-old woman presented with a 2-year history of left inguinal and lumbar pain. She reported increased pain after physical activity. Magnetic resonance imaging of the left femur (without intravenous gadolinium) showed a mass extending 14 cm along the femoral metaphysis. This lesion involved cortical bone that was broken in the posteromedial site. Computed tomography confirmed the osteostructural lytic alteration that "blows up" the proximal femur metaphysis. A trochar biopsy allowed the diagnosis of aneurysmal bone cyst on fibrous dysplasia, excluding malignancy. The lesion was treated with curettage and local adjuvants and filled with bone grafts. Internal fixation with a sliding screw plate was also performed. Radiographs at 1 year postoperatively showed good consolidation of the grafts and absence of local recurrence. The patient achieved active and passive mobilization of the left hip with no pain. PMID:19472953

Montalti, Maurizio; Alberghini, Marco; Ruggieri, Pietro

2009-05-01

 
 
 
 
201

Fibrous tissue and angiotensin II.  

Science.gov (United States)

Myofibroblasts (myoFb) are cells responsible for fibrous tissue formation in injured systemic organs such as the heart. Cultured myoFb, obtained from rat cardiac scar tissue, express genes that encode components requisite for angiotensin (Ang) II generation, which in turn regulates myoFb collagen turnover in an autocrine/paracrine manner. In this study, we tested the hypothesis that these wound-healing fibroblast-like cells and locally generated Ang II are involved in other repairing tissue. To test this hypothesis, we used a granuloma pouch model, where a subcutaneous air sac is created followed by injection of croton oil. Pouch tissue was collected at days 4, 7, 14 and 21. The presence of myoFb was determined by immunohistochemical alpha-smooth muscle actin (alpha-SMA) labeling and collagen accumulation by picrosirius red staining. Angiotensin converting enzyme (ACE) and Ang II receptor binding were detected by in vitro quantitative autoradiography using 125I-351A and 125I[Sar1, Ile8]Ang II, respectively, while Ang II receptor subtype was defined by displacement studies using either an AT1 (losartan) or AT2 (PD123177) receptor antagonist. Cells expressing ACE were determined by immunohistochemistry. Ang II content in pouch tissue was measured by radioimmunoassay following HPLC separation while its capacity to generate Ang II was assessed in tissue bath, with and without exogenous Ang I or lisinopril, an ACE inhibitor. Collagen accumulation in pouch tissue was examined by determining hydroxyproline content in response to lisinopril, AT1 or AT2 receptor antagonists (losartan or PD123177). In pouch tissue, we found: (1) myoFb at day 4 which became more extensive at days 7, 14 and 21; (2) morphologic evidence of collagen deposition evident at day 4, which gradually became more extensive thereafter; (3) ACE and Ang II receptor binding was evident at day 4 and remained invariant on days 7, 14 and 21; (4) the predominant Ang II receptor subtype expressed was AT1; (5) myoFb express ACE and AT1 receptors; (6) picogram quantities of Ang II (per g tissue) was evident on days 7, 14 and 21; and (7) Ang II was generated from Ang I substrate. Lisinopril and losartan, but not PD123177, significantly attenuated pouch weight and accumulation of collagen. Thus, in this model of cutaneous repair, the appearance of myoFb is associated with Ang II generation that regulates fibrogenesis by AT1 receptor binding. Signals involved in the appearance of myoFb remain uncertain. Further studies are required to address the regulation of Ang II generation in pouch tissue of the rat. PMID:9281434

Sun, Y; Ramires, F J; Zhou, G; Ganjam, V K; Weber, K T

1997-08-01

202

Solitary fibrous tumor of the thyroid gland.  

Science.gov (United States)

Solitary fibrous tumor is a spindle cell neoplasm rarely arising in the thyroid gland. We present a 78-year-old man with the diagnosis of solitary fibrous tumor of the thyroid gland resected by subtotal thyroidectomy. Fine needle aspiration cytology via ultrasound guidance demonstrated a hypocellular aspirate that revealed follicular epithelial cells with mild nuclear atypia and scattered spindle cells with bland nuclei. Histologically, the patternless proliferation of spindle cells was seen among collagenous bundles, accompanied by hemangiopericytomatous vessels, and variously dilated follicles with mild atypical cells having slightly enlarged nuclei, indicating adenomatous goiter. The neoplastic spindle cells showed diffuse immunoreactivity to CD34, bcl-2, CD99 and vimentin, but were negative for cytokeratins, calcitonin, TTF-1 and CD5. Although solitary fibrous tumor arising in thyroid gland is rare, this tumor should be included in the differential diagnosis of thyroid spindle cell tumors and also that of adenomatous. PMID:24013381

Mizuuchi, Yusuke; Yamamoto, Hidetaka; Nakamura, Katsuya; Shirahane, Kengo; Souzaki, Masae; Tanaka, Masao; Oda, Yoshinao

2014-06-01

203

Complex cellular composition of solitary fibrous tumor of the prostate.  

Science.gov (United States)

Solitary fibrous tumors (SFTs) of the prostate are a rare type of spindle cell neoplasm that can demonstrate either a benign or malignant phenotype. SFTs represent a clinical challenge along with other spindle cell lesions of the prostate in terms of both diagnosis and treatment. The present study shows, for the first time, that SFTs of the prostate and other organs can comprise a mixed population of fibroblast, myofibroblast, and smooth muscle cell types. The highly proliferative component demonstrated a fibroblastic phenotype that readily underwent myofibroblast differentiation on exposure to profibrotic stimuli. Consistent with other recent studies, the prostatic SFTs demonstrated NAB2-STAT6 gene fusions that were also present in the fibroblast, myofibroblast, and smooth muscle cell types of the SFT. The results of these studies suggest that benign and malignant prostatic tumors of mesenchymal origin may be distinguished at the molecular and cellular levels, and that delineation of such defining characteristics may help elucidate the etiology and prognosis of such tumors. PMID:24434011

Gharaee-Kermani, Mehrnaz; Mehra, Rohit; Robinson, Dan R; Wei, John T; Macoska, Jill A

2014-03-01

204

Primary solitary fibrous tumor of the retroperitoneum  

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Full Text Available Solitary fibrous tumor is an uncommon neoplasm affecting adults and typically located in the pleura and can also occur in a large number of other extra thoracic sites. We present the case of a solitary fibrous tumor (SFT of the retroperitoneum and describe their histopathological and immunohistochemical features. The identification of SFT in the retroperitoneum is of importance because its clinico-pathological behaviour is still unclear. The pathologist plays a fundamental role in establishing both the positive and differential diagnosis.

Najat Mahassini

2011-09-01

205

On the filtration of fibrous aerosols  

International Nuclear Information System (INIS)

Basic peculiarities occuring during the filtration of fibrous aerosols are discussed. Using aerosols of very fine asbestos fibers, filtration efficiencies of some analytical filters -Nuclepore and Millipore filters - were investigated. The collection efficiences were measured by means of electron microscopy and radiolabeled asbestos fibers. The collection efficiencies, which depended on the pore sizes of the filters and on the fiber form of the used aerosol, lay in the range of about 40-99.9%. A special problem discussed is the orientation of fibrous particles in the vicinity of filter pore entrances. (author)

1986-06-01

206

Fibrous pseudotumor of the epididymis: imaging and pathologic correlation  

Energy Technology Data Exchange (ETDEWEB)

We report the case of a 25-year-old man who presented a fibrous pseudotumor of the epididymis, a rare focal location of nodular and diffuse fibrous proliferation. We provide the ultrasonographic and MRI findings with pathologic correlation. (orig.)

Krainik, A.; Sarrazin, J.L.; Cordoliani, Y.S. [Hopital d' Instruction des Armees du Val de Grace, Paris (France). Dept. of Radiology; Camparo, P. [Hopital d' Instruction des Armees du Val de Grace, Paris (France). Dept. of Pathology; Vincendeau, S.; Houlgatte, A. [Hopital d' Instruction des Armees du Val de Grace, Paris (France). Dept. of Urology

2000-10-01

207

[Chronic invasive fibrous thyroiditis (Riedel struma). Case report with special reference to preoperative diagnosis].  

Science.gov (United States)

Chronic invasive fibrous thyroiditis (Riedel's struma) is a very rare disease of unknown aetiology mainly affecting middle-aged or old female patients. An aggressive fibrosis partly or totally replaces normal thyroid gland tissue. The gland becomes stony hard, is not displaceable and, characteristically, the fibrous tissue penetrates the capsule and infiltrates into surrounding structures such as muscles, vessels, nerves and even the trachea. Riedel's struma is often associated with fibrotic processes in other parts of the body. The preoperative differential diagnosis includes malignant tumours and fibrosing stages of Hashimoto's disease, as well as subacute thyroiditis de Quervain. This paper reports the case of a 60-year-old woman suffering from Riedel's struma and discusses differential diagnostic aspects with regard to preoperative investigation and pathohistology. PMID:3287769

Beham, A; Langsteger, W; Schmid, C; Lind, P; Kronberger, D

1988-04-01

208

Fibrous vaginal hamartoma in a newborn calf  

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A 2-day-old female Holstein calf was presented for abnormal structures protruding from the vulva at birth. A diagnosis of fibrous vaginal hamartoma was made, based on macroscopic and histologic examinations of the abnormal tissue. Management of this case involved surgical mass ablation.

Lafond, Jean-franc?ois; Mulon, Pierre-yves; Drolet, Richard

2008-01-01

209

Steam Reformer With Fibrous Catalytic Combustor  

Science.gov (United States)

Proposed steam-reforming reactor derives heat from internal combustion on fibrous catalyst. Supplies of fuel and air to combustor controlled to meet demand for heat for steam-reforming reaction. Enables use of less expensive reactor-tube material by limiting temperature to value safe for material yet not so low as to reduce reactor efficiency.

Voecks, Gerald E.

1987-01-01

210

Development of oxide fibrous monolith systems.  

Energy Technology Data Exchange (ETDEWEB)

Fibrous monolithic ceramics generally have a cellular structure that consists of a strong cell surrounded by a weaker boundary phase [1-5]. Fibrous monoliths (FMs) are produced from powders by conventional ceramic fabrication techniques, such as extrusion [1,2]. When properly engineered, they exhibit fail gracefully [3-5]. Several compositions of ceramics and cermets have been processed successfully in fibrous monolithic form [4]. The most thoroughly investigated fibrous monolith consists of Si{sub 3}N{sub 4} cells and a BN cell-boundary phase [3-5]. Through appropriate selection of initial powders and extrusion and hot-pressing parameters, very tough final products have been produced. The resultant high toughness is due primarily to delamination during fracture along textured platelike BN grains. The primary objectives of our program are to develop: (1) Oxide-based FMs, including new systems with improved properties; (2) FMs that can be pressureless sintered rather than hot-pressed; (3) Techniques for continuous extrusion of FM filaments, including solid freeform fabrication (SFF) for net-shape fabrication of FMs; (4) Predictive micromechanical models for FM design and performance; and (5) Ties with industrial producers and users of FMs.

Goretta, K. C.

1999-03-02

211

Temporosphenoidal Fibrous Dysplasia: A Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available Fibrous dysplasia (FD is a localized disorder of bone that may lead to bony distortional expansions. We report a case of FD of the temporosphenoidal bone. In this case, we took out subtotally the part of the temporal bone extending to the skull base with speed-drilling.

Mustafa ERDAL

2006-12-01

212

Study of plutonium adsorption by fibrous adsorbent  

International Nuclear Information System (INIS)

Japan Atomic Energy Research Institute and Unitika Ltd. have been conducting, under a joint effort, development of an inorganic fibrous adsorbent (FAC), which is capable of adsorbing plutonium (Pu) contained in radioactive liquid waste and which is also able to contribute to reduction of the volume of ?-waste by incineration. The fibrous adsorbent constitutes fibrous activated carbon of coal tar pitch derivative and has the following characteristics: (1) It has a large surface area. (2) Carbon constitutes more than 90% in the adsorbent; it is physically and chemically stable as an inorganic adsorbent; it is easy to be incinerated. (3) It is easy to be formed or molded into different shapes such as cartridges, and handling of the material is extremely easy. By using various kinds of Pu solution, we carried out tests and evaluations on the equilibrium adsorption quantity of Pu by the fibrous adsorbent, the adsorption property of the material by flow-through column test and the incineration property of the material in the cold test. The tests show that: (1) adsorption of Pu is the best with 0.8?0.9 mg-Pu/g-FAC when the concentration of nitric acid is near 1 M; (2) as the concentration of nitric acid is increased, its adsorption capacity becomes poorer; (3) when Pu coexists with Uranium (U), the adsorption capacity becomes slightly inferior; (4) in the flow-through column test, no breakthrough of Pu was observed until the volume of Pu liquid becomes about 3 times larger than the column volume; (5) in the incineration tests in the cold test using a laboratory scale incinerator, no flying of particles or soot was observed; and (6) it is possible to get good incineration at 500 ? 600 degrees C. The above results show that, by using the fibrous adsorbent, it became possible to remove Pu from radioactive liquid waste by adsorption, to reduce the volume only to residual ash by incineration, and to reduce substantially the volume of ?-waste

1994-03-03

213

Malignant hyperthermia  

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Malignant hyperthermia (MH) is an uncommon, life-threatening pharmacogenetic disorder of the skeletal muscle. It presents as a hypermetabolic response in susceptible individuals to potent volatile anesthetics with/without depolarizing muscle relaxants; in rare cases, to stress from exertion or heat stress. Susceptibility to malignant hyperthermia (MHS) is inherited as an autosomally dominant trait with variable expression and incomplete penetrance. It is known that the pathophysiology of MH i...

Kim, Dong-chan

2012-01-01

214

Electron microprobe identification of fibrous aerosols in ambient air  

International Nuclear Information System (INIS)

Nuclepore filters were used for sampling fibrous particles in ambient air. The fiber counting and fiber size measurements were done by means of SEM-methods. The number of fibers, distribution of fiber lengths, and diameters were plotted. The specific identification of asbestos fibers was made by electron microprobe analysis. Certain elements such as Si, Fe, Mg, Al, Mn, Ca, and Na as well as ratios such as Fe/Si and Mg/Si proved to be approximative identification factors for ambient asbestos. Not only asbestos and glass, also many other inorganic fibrous particles were found in the urban atmosphere as well as in the atmosphere of remote regions. Fibrous gypsum, fibrous ammonium sulfates, fibrous silicates, fibrous mica, and quartz were identified among these particles. Even in remote ambient air, relatively high concentrations of fibrous particles (103-104 m-3) could be measured, although the concentration of asbestos fibers were usually smaller than 102 m-3

1977-10-12

215

What Is Malignant Mesothelioma?  

Science.gov (United States)

... the key statistics about malignant mesothelioma? What is malignant mesothelioma? Malignant mesothelioma is a cancer that starts ... can be non-cancerous (benign) or cancerous (malignant). Malignant mesothelioma A cancerous tumor of the mesothelium is ...

216

Reactive Nodular Fibrous Pseudotumor: Case Report and Review of the Literature  

Science.gov (United States)

We will describe a case of a patient diagnosed with a rare identity of a benign lesion, “reactive nodular fibrous pseudotumor” (RNFP). It is a tumor which preoperatively can present as a malignant tumor and is only reported in 19 cases. According to the very limited amount of information on this tumor in the literature it is mostly seen after trauma or intraperitoneal inflammation. Our case is the second one of RNFP associated with endometriosis, which is a frequently seen intraperitoneal inflammation process in women. Knowledge that these large pseudotumoral lesions can occur is important to direct the management of these patients.

Salihi, Rawand; Moerman, Philippe; Timmerman, Dirk; Van Schoubroeck, Dominique; Op de beeck, Katya; Vergote, Ignace

2014-01-01

217

Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia  

Energy Technology Data Exchange (ETDEWEB)

We describe two cases of elderly women who presented hypoglycemic episodes with suppressed levels of insulin and insulin-like growth factor I. They were found to have huge malignant solitary fibrous tumor of the pleura. The tumors had rich vascularization on enhanced CT scans and showed characteristic low signal intensity on T2-weighted MR images. This paraneoplastic hypoglycemia is caused by an incompletely processed precursor of insulin-like growth factor II secreted from the tumor. Hypoglycemia and insulin suppression were resolved after removal of the tumors. (orig.)

Kim, J.H. [Dept. of Diagnostic Radiology, Chungnam National University Hospital, Taejon (Korea); Kim, J.O.; Kim, S.Y. [Dept. of Internal Medicine, Chungnam National University Hospital, Taejon (Korea); Na, M.H.; Lim, S.P. [Dept. of Thoracic Surgery, Chungnam National University Hospital, Taejon (Korea); Kim, J.M. [Dept. of Pathology, Chungnam National University Hospital, Taejon (Korea)

2001-05-01

218

Calcifying fibrous tumour: an unusual omental lesion  

International Nuclear Information System (INIS)

Calcifying fibrous tumour (CFT) is a recently described distinct clinicopathological entity characterized by calcifying lesions usually occurring in soft tissue of the extremities, trunk, axilla, pleura, mediastinum and peritoneum of children and adults. Most reported cases involving the peritoneum have been in adults. We present the imaging, surgical and pathology findings of CFT in a 7-year-old child who presented with an incidental finding of a large omental mass. (orig.)

2008-11-01

219

Aerosol filtration with metallic fibrous filters  

International Nuclear Information System (INIS)

The filtration efficiency of stainless steel fibrous filters (BEKIPOR porous mats and sintered webs) is determined using submicronic monodisperse polystyrene aerosols. Lasers spectrometers are used for the aerosol measurements. The parameters varied are the fiber diameter, the number of layers, the aerosol diameter and the superficial velocity. Two selected types of filters are tested with polydisperse methylene blue aerosols to determine the effect of bed loading on the filter performance and to test washing techniques for the regeneration of the filter

1983-02-01

220

Toughened uni-piece fibrous insulation  

Science.gov (United States)

A porous body of fibrous, low density silica-based insulation material is at least in part impregnated with a reactive boron oxide containing borosilicate glass frit, a silicon tetraboride fluxing agent and a molybdenum silicide emittance agent. The glass frit, fluxing agent and emittance agent are separately milled to reduce their particle size, then mixed together to produce a slurry in ethanol. The slurry is then applied to the insulation material and sintered to produce the porous body.

Leiser, Daniel B (inventor); Smith, Marnell (inventor); Churchward, Rex A. (inventor); Katvala, Victor W. (inventor)

1992-01-01

 
 
 
 
221

First description of Phanerozoic radiaxial fibrous dolomite  

Science.gov (United States)

The petrographic analysis and crystallographic analysis of concretionary carbonate cements ("coal balls") from Carboniferous paralic swamp deposits reveal the presence of (length fast) radiaxial fibrous dolomite (RFD), a fabric not previously reported from the Phanerozoic. This finding is of significance as earlier reports of Phanerozoic radiaxial fibrous carbonates are exclusively of calcite mineralogy. Dolomite concretions described here formed beneath marine transgressive intervals within palustrine coal seams. This is of significance as seawater was arguably the main source of Mg2 + ions for dolomite formation. Here, data from optical microscopy, cathodoluminescence, electron backscattered diffraction, X-ray diffraction and geochemical analyses are presented to characterize three paragenetic dolomite phases and one calcite phase in these concretions. The main focus is on the earliest diagenetic, non-stoichiometric (degree of order: 0.41–0.46) phase I, characterized by botryoidal dolomite constructed of fibres up to 110 ?m wide with a systematic undulatory extinction and converging crystal axes. Petrographic and crystallographic evidence clearly qualifies phase I dolomite as radiaxial fibrous. Conversely, fascicular optical fabrics were not found. Carbon-isotope ratios (?13C) are depleted (between ? 11.8 and ? 22.1‰) as expected for carbonate precipitation from marine pore-fluids in organic-matter-rich, paralic sediment. Oxygen isotope (?18O) ratios range between ? 1.3 and ? 6.0‰. The earliest diagenetic nature of these cements is documented by the presence of ubiquitous, non-compacted fossil plant remains encased in phase I dolomite as well as by the complex zoned luminescence patterns in the crystals and is supported by crystallographic and thermodynamic considerations. It is argued that organic matter, and specifically carboxyl groups, reduced thermodynamic barriers for dolomite formation and facilitated Mg/CaCO3 precipitation. The data shown here reveal a hitherto unknown level of complexity with respect to radiaxial fibrous carbonates and are of importance for those concerned with dolomite and carbonate petrography in general.

Richter, D. K.; Heinrich, F.; Geske, A.; Neuser, R. D.; Gies, H.; Immenhauser, A.

2014-05-01

222

Solitary fibrous tumor of the prostate.  

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A case of solitary fibrous tumor of the prostate is reported. A 42-year-old man had been complaining of difficult voiding and constipation for 8 years. Urological and radiological examinations showed a large prostatic mass, and a total cystectomy and prostatectomy were performed. The tumor was 14 x 13 x 11 cm in size, solid with a fibromuscular capsule, and gray-tan in color. Histologically, the tumor was composed of short spindle-shaped and polygonal cells with mild to moderate nuclear atypia, predominantly arranged in the so-called 'patternless pattern' in a fibrocollagenous background. Mitoses were occasionally seen. Vascular invasion was also observed. Immunohistochemically, these cells were strongly positive for CD34 and vimentin, and occasionally for desmin. The maximum Ki-67 labeling index of the tumor cells was 4.5%. These findings are consistent with a solitary fibrous tumor. To our knowledge, this is the first report of a solitary fibrous tumor of the prostate in the English medical literature. PMID:9361107

Takeshima, Y; Yoneda, K; Sanda, N; Inai, K

1997-10-01

223

Toxicity and Carcinogenicity Mechanisms of Fibrous Antigorite  

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Full Text Available We studied the effects of fibrous antigorite on mesothelial MeT-5A and monocyte-macrophage J774 cell lines to further understand cellular mechanisms induced by asbestos fibers leading to lung damage and cancer. Antigorite is a mineral with asbestiform properties, which tends to associate with chrysotile or tremolite, and frequently occurs as the predominant mineral in the veins of several serpentinite rocks found abundantly in the Western Alps. Particles containing antigorite are more abundant in the breathing air of this region than those typically found in urban ambient air. Exposure of MeT-5A and J774 cells to fibrous antigorite at concentrations of 5-100 μg/ml for 72 hr induced dose-dependent cytotoxicity. Antigorite also stimulated the ROS production, induced the generation of nitrite and PGE2. MeT-5A cells were more sensitive to antigorite than J774 cells. The results of this study revealed that the fibrous antigorite stimulates cyclooxygenase and formation of hydroxyl and nitric oxide radicals. These changes represent early cellular responses to antigorite fibers, which lead to a host of pathological and neoplastic conditions because free radicals and PGE2 play important roles as mediators of tumor pathogenesis. Understanding the mechanisms of the cellular responses to antigorite and other asbestos particles should be helpful in designing rational prevention and treatment approaches.

Michael Balazy

2007-03-01

224

A Case of Extensive polyostotic fibrous dysplasia  

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Fibrous dysplasia is a benign disorder of bone consisting of intramedullary proliferation of fibrous tissue and irregularly distributed, poorly developed bone. The disease manifests itself in the monostotic form in which only one bone is involved and the polyostotic form in which multiple bones at different sites are affected. We reported a extensive case of polyostotic fibrous dysplasia with involvement of craniofacial bones, mandible, ribs, extremities. A 18-year-old man showed remarkable right facial swelling who had been treated on right femur 3 years ago with a bone graft for pathologic fracture and he recognized facial swelling 5 years ago. Extraoral radiograms and computed tomogram showed diffuse sclerosis with a ground glass appearance of the most calvarial bones, facial bones. The right mandibular lesion showed very expansible lesion with mottled appearance. Bone scans showed multifocal increased uptakes in craniofacial bones, right mandible, bilaterally in ribs, humerus, femur, tibia and characteristic various deformity of right femur (shepherd's crook deformity). This case showed exceptionally bilateral, extensive nature of bone lesion and didn't show any features of skin pigmentation and endocrine disturbances.

Lee, Byung Do [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Wonkwang University, Iksan (Korea, Republic of); Hwang, Eui Hwan; Lee, Sang Rae [Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Kyunghee University, Seoul (Korea, Republic of)

2000-06-15

225

Microbial nature of fibrous kerite of Volyn  

Science.gov (United States)

For the last few years there have been a lot of publications in geological literature on the problem of formation of morphologically unique fine fibrous kerites, found in one of the objects of kamera pegmatites of Volyn (1800 - 1750 mln. years). According to the opinion of all researchers who deal with them, they are an excellent example of a biogenic, highly constructive carbon substance. The meeting of objectives set was carried out by means of the study of ultra-thin section and replicas of kerite cryofractures under high resolution electronic microscope. The similarity of fine structured fibrous kerite of Volyn (KV) to prokaryotic microorganisms is proved by availability in KV of clearly exposed cellular ultrastructures: multilayered cell wall, cross septa and cytoplasmatic membrane and `intracytoplasmic' inclusions. Fatty acids obtained from kerites contain a number of components typical of prokaryotic microbial community. Suggestions were made on the formation of fibrous Volyn's kerites as a result of mummification of the cyanobacterial mat components from freshwater thermal spring of moderate temperature. Thus, the detailed fine structure of microfossils and their fatty acid composition can be used to support evidence of biogenic origin of the bacteriomorphic elements in paleo- and space objects.

Gorlenko, Vladimir M.; Zhmur, Stanislav I.; Duda, Vitalii I.; Osipov, George A.; Suzina, Natalia; Dmitriev, Vladimir V.

1999-12-01

226

Expression of CD44 and MMP-2: Possible Association with Histopathological Features of Pleuro-Pulmonary Solitary Fibrous Tumors  

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Full Text Available Objective: Recent studies have shown that tumor cell adhesion molecules CD44 and matrix metalloproteinases (MMP-2 are expressed strongly in many tumors and associated closely with invasion and metastasis of these tumors. Although solitary fibrous tumors (SFT have a good prognosis, a minority behave malignantly. The aim of this study was to analyze the correlation between CD44 and MMP-2 expression with histopathological parameters in SFT.Material and Method: Haemotaxylin-Eosin stained sections of 10 patients with SFT were reexamined for evaluation of histopathological parameters. Immunostaining of CD44 and MMP-2 was performed by using the streptavidin-biotin method with mouse monoclonal antibody.Results: Our cases consisted of three male and seven female patients with a mean age of 54.5 years. Three patients had a history of asbest exposure. Complete resection was performed in 2 malignant (multiple masses and 8 benign SFT cases. One intrapulmonary tumor was treated with pneumonectomy. 3 cases originated from the right and 7 from the left hemithorax. Tumor size ranged from 5 to 27cm. All cases expressed strong CD44. Only 2 malignant SFT and intrapulmonary SFT expressed focal MMP-2.Conclusion: Although MMP-2 positivity was observed in 2 malignant cases, CD44 positivity was not associated with malignancy criteria in solitary fibrous tumors.

Funda DEM?RA?

2011-05-01

227

Malignant mesothelioma  

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Full Text Available Abstract Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis. The exact prevalence is unknown but it is estimated that mesotheliomas represent less than 1% of all cancers. Its incidence is increasing, with an expected peak in the next 10–20 years. Pleural malignant mesothelioma is the most common form of mesothelioma. Typical presenting features are those of chest pain and dyspnoea. Breathlessness due to a pleural effusion without chest pain is reported in about 30% of patients. A chest wall mass, weight loss, sweating, abdominal pain and ascites (due to peritoneal involvement are less common presentations. Mesothelioma is directly attributable to occupational asbestos exposure with a history of exposure in over 90% of cases. There is also evidence that mesothelioma may result from both para-occupational exposure and non-occupational "environmental" exposure. Idiopathic or spontaneous mesothelioma can also occur in the absence of any exposure to asbestos, with a spontaneous rate in humans of around one per million. A combination of accurate exposure history, along with examination radiology and pathology are essential to make the diagnosis. Distinguishing malignant from benign pleural disease can be challenging. The most helpful CT findings suggesting malignant pleural disease are 1 a circumferential pleural rind, 2 nodular pleural thickening, 3 pleural thickening of > 1 cm and 4 mediastinal pleural involvement. Involvement of a multidisciplinary team is recommended to ensure prompt and appropriate management, using a framework of radiotherapy, chemotherapy, surgery and symptom palliation with end of life care. Compensation issues must also be considered. Life expectancy in malignant mesothelioma is poor, with a median survival of about one year following diagnosis.

Parker Robert J

2008-12-01

228

Nature and extent of the exposure to fibrous amphiboles in Biancavilla.  

Science.gov (United States)

An epidemiological and environmental study in the Biancavilla area (Sicily, Italy) was recently prompted by an impressively high incidence of malignant pleural mesothelioma. Epidemiology suggested an environmental contamination by amphibole fibres rather than risks related to a specific occupational activity. The aim of this study is to describe the diffusion of fibrous amphiboles in the area and identify their source. Fibrous amphiboles were found in the products from the local quarries, which had been used for years to build houses. After sampling all around Biancavilla, three sites were detected and they were characterized by an abundant presence of mineral fibres. Fibrous amphiboles were also recovered from building materials (mortar and plasters) and airborne particulates sampled in urban sites with high dust emissions due mainly to unpaved roads. Moreover, amphibole fibres were detected in the lung tissue of a woman who died of pleural mesothelioma. The results of this study suggest that the amphibole fibre diffusion in the Biancavilla environment lasted for many years and had been maximum during the sixties and the seventies with the uncontrolled development of the local building industry. Today, the environmental situation results to be changed following both the closing of the stone quarries and the urbanization works after 2001, above all the asphalting of dusty roads. Anyway sporadic mesothelioma cases have still to be expected in the next years. PMID:16806404

Bruni, B M; Pacella, A; MazziottiTagliani, S; Gianfagna, A; Paoletti, L

2006-10-15

229

Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia  

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Full Text Available We report a case of a 32 year-old male, admitted for a lytic lesion of the distal femur. One month after the first X-ray, clinical and imaging deterioration was evident. Open biopsy revealed fibrous dysplasia. Three months later, the lytic lesion had spread to the whole distal third of the femur reaching the articular cartilage. The malignant clinical and imaging features necessitated excision of the lesion and reconstruction with a custom-made total knee arthroplasty. Intra-operatively, no obvious soft tissue infiltration was evident. Nevertheless, an excision of the distal 15.5 cm of the femur including 3.0 cm of the surrounding muscles was finally performed. The histological examination of the excised specimen revealed central low-grade osteosarcoma. Based on the morphological features of the excised tumor, allied to the clinical findings, the diagnosis of low-grade central osteosarcoma was finally made although characters of a fibrous dysplasia were apparent. Central low-grade osteosarcoma is a rare, well-differentiated sub-type of osteosarcoma, with clinical, imaging, and histological features similar to benign tumours. Thus, initial misdiagnosis is usual with the condition commonly mistaken for fibrous dysplasia. Central low-grade osteosarcoma is usually treated with surgery alone, with rare cases of distal metastases. However, regional recurrence is quite frequent after close margin excision.

Haris S Vasiliadis

2013-01-01

230

Fibrous Hamartoma of Infancy, Report of Two Cases  

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Full Text Available Objective: Fibrous hamartoma of infancy (FHI is a rare, benign soft tissue tumor that typically occurs within the first two years of life. It has a specific histologic appearance comprising of three different mesenchymal tissues with variable proportions in an organoid fashion. The clinical course is typically benign with excellent prognosis. We report two cases of this rare lesion and review its cilinicopathologic characteristics. Case(s Presentation: The first case was a 15-month-old girl who had a subcutaneous mass in the right axillary region and the other one was an 18-month-old boy with a mass on the medial surface of his right ankle. The masses were successfully excised. After 6 and 30 months follow up no recurrence occurred. Conclusion: Although the clinical and imaging findings of FHI are quite similar to those of malignant soft tissue tumor, histologic characteristics of this tumor will guide to the definite diagnosis that will prevent aggressive and mutilating procedures.

Ahmad Bazrafshan

2008-05-01

231

Intramuscular myxoma and fibrous dysplasia of bone - Mazabraud's syndrome  

International Nuclear Information System (INIS)

We present a case of Mazabroud's syndrome, a rare benign disease, with multiple intramuscular myxomas of the thoracic wall associated with fibrous dysplasia of bone. CT, MR imaging and ultrasonography (US) of the thorax showed 2 well circumscribed homogeneous intramuscular tumors. A US-guided needle biopsy with a large-core needle (2.0 mm) and a fine needle (0.8 mm) showed that the tumors were intramuscular myxomas with no sign of malignancy. 99mTc bone scintigraphy showed a markedly increased uptake in the right lower skull, and multiple smaller foci. CT of the skull revealed a right-sided unilateral bone thickening of the orbit and the ethomoidal cells, and right-sided exophthalmia. This case history suggests that patients with multiple intramuscular myxomas should be preoperatively examined for osseous lesions. A postoperative follow-up should also be performed to detect other soft-tissue myxomas not as yet clinically detectable, or rare osseous complications. (orig.)

1997-05-01

232

Hematologic malignancies  

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The principle aim of this book is to give practical guidelines to the modern treatment of the six important hematologic malignancies. Topics considered include the treatment of the chronic leukemias; acute leukemia in adults; the myeloproliferative disorders: polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis/agnogenic myeloid metaplasia; Hodgkin's Disease; non-Hodgkin's lymphoma; and Multiple Myeloma.

Hoogstraten, B.

1986-01-01

233

Hematologic malignancies  

International Nuclear Information System (INIS)

The principle aim of this book is to give practical guidelines to the modern treatment of the six important hematologic malignancies. Topics considered include the treatment of the chronic leukemias; acute leukemia in adults; the myeloproliferative disorders: polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis/agnogenic myeloid metaplasia; Hodgkin's Disease; non-Hodgkin's lymphoma; and Multiple Myeloma

1986-01-01

234

Benign calcifying fibrous-myofibroblastic tumor mimicking myositis ossificans in a 22-month-old girl.  

Science.gov (United States)

Myositis ossificans circumscripta (MOC), with nonneoplastic heterotopic bone formation in soft tissue and skeletal muscle, is rare in children. Extraskeletal osteosarcoma is a very rare malignant mesenchymal neoplasm of soft tissues in children. At onset, it may be difficult to distinguish MOC from a musculoskeletal infection or neoplasm, particularly in the absence of trauma, and a biopsy is frequently required. However, differentiating MOC from malignant neoplasm is imperative. We describe the case of a 22-month-old girl who presented with a benign fibrous-myofibroblastic tumor mimicking MOC. However, extraskeletal osteosarcoma was also considered in the differential diagnosis due to the absence of attachment of the lesion to the skeleton. Pathologic findings after a previous needle biopsy and posterior marginal resection exclude both differential diagnoses. Close follow-up during 3 years postoperatively showed no signs of recurrence. PMID:21763824

Gil-Albarova, Jorge; Gómez-Palacio, Victoria Eugenia; Fuertes-Zarate, Ana; Herrera, Antonio

2011-07-01

235

AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma  

Science.gov (United States)

Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Rhabdomyosarcoma; Dermatofibrosarcoma Protuberans; Endometrial Stromal Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Uterine Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage III Uterine Sarcoma; Stage IV Adult Soft Tissue Sarcoma; Stage IV Uterine Sarcoma; Uterine Carcinosarcoma; Uterine Leiomyosarcoma

2013-05-07

236

Heimlich valve treatment and outpatient management of bilateral metastatic pneumothorax.  

Science.gov (United States)

A 51-year-old man was treated for bilateral pneumothorax secondary to pulmonary metastases from malignant fibrous histiocytoma. After failure of regular therapy, Heimlich flutter valves were used producing disappearance of the bilateral pneumothorax and adequate outpatient management. PMID:8181364

Van Hengel, P; Van de Bergh, J H

1994-05-01

237

Sorafenib in Treating Patients With Metastatic, Locally Advanced, or Recurrent Sarcoma  

Science.gov (United States)

Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Leiomyosarcoma; Adult Malignant Fibrous Histiocytoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Ovarian Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Uterine Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage III Uterine Sarcoma; Stage IV Adult Soft Tissue Sarcoma; Stage IV Uterine Sarcoma; Uterine Carcinosarcoma; Uterine Leiomyosarcoma

2014-05-07

238

Calcifying fibrous pseudotumor of mediastinum--a case report.  

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This report presents a case of calcifying fibrous pseudotumor arising in the posterior mediastinum of a 54-year-old woman. The histopathologic features of this case were identical to that of calcifying fibrous pseudotumor first designated in 1993. It is a distinctive benign fibrous lesion characterized by the presence of characteristics psammomatous or dystrophic calcification, abundant hyalinized collagen and lymphoplasmacytic cell infiltrate. Immunohistochemically most of the scattered fibr...

1997-01-01

239

Giant solitary fibrous tumor pleura: Clinical dilemma and diagnosis  

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Solitary fibrous tumors in the lung are rare neoplasms with distinct clinicopathological and immunohistochemical features. We report a giant solitary fibrous tumor of the pleura in a young male which remained silent clinically till it assumed gigantic proportions. Histology and immunohistochemistry were classical of a solitary fibrous tumor. Inspite of its appalling size it proved to be benign in behavior. This case depicts the vulnerability of this lesion to a clinical bungle. The report hig...

Kaur, Amulyajit; Gill, Satyajit Singh; Singh, Jaswinder; Singh, Amandeep; Mani, Narayanan Subramaniam

2012-01-01

240

Malignant hyperthermia  

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Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stresses such as vigorous exercise and heat. The incidence of MH reactions ranges from 1:5,000 to 1:50,000–100,000 anesthesias. However, the prevalence of the genetic abnormalities may be as great as one in 3,000 ind...

Rosenberg, Henry; Davis, Mark; James, Danielle; Pollock, Neil; Stowell, Kathryn

2007-01-01

 
 
 
 
241

Malignant hyperthermia.  

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Malignant hyperthermia is a rare autosomal dominant trait that predisposes affected individuals to great danger when exposed to certain anaesthetic triggering agents (such as potent volatile anaesthetics and succinylcholine). A sudden hypermetabolic reaction in skeletal muscle leading to hyperthermia and massive rhabdomyolysis can occur. The ultimate treatment is dantrolene sodium a nonspecific muscle relaxant. Certain precautions should be taken before anaesthesia of patients known to be sus...

Ben Abraham, R.; Adnet, P.; Glauber, V.; Perel, A.

1998-01-01

242

Fibrous composites comprising carbon nanotubes and silica  

Science.gov (United States)

Fibrous composite comprising a plurality of carbon nanotubes; and a silica-containing moiety having one of the structures: (SiO).sub.3Si--(CH.sub.2).sub.n--NR.sub.1R.sub.2) or (SiO).sub.3Si--(CH.sub.2).sub.n--NCO; where n is from 1 to 6, and R.sub.1 and R.sub.2 are each independently H, CH.sub.3, or C.sub.2H.sub.5.

Peng, Huisheng (Shanghai, CN); Zhu, Yuntian Theodore (Cary, NC); Peterson, Dean E. (Los Alamos, NM); Jia, Quanxi (Los Alamos, NM)

2011-10-11

243

Imaging Findings of Fibrous Hamartoma of Infancy  

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We wanted to evaluate the imaging findings of fibrous hamartoma of infancy (FHI). We retrospectively reviewed the clinical presentation and the sonographic (n = 5) and CT (n = 3) findings of 5 cases of surgically/pathologically confirmed FHI. The sonographic findings were evaluated according to the location, size, internal echogenicity and vascularity. The CT findings were evaluated according to the attenuation of the mass on both the pre- (n = 3) and postcontrast (n = 2) scans. The image findings were correlated with the pathologic findings. The mean age was 14.8 months (range, 7 months - 3 years). The location of lesions was all in the fatty layer of the back (n = 4) and upper arm (n = 1). All the lesions demonstrated-hypertrichosis on the overlying skin. The lesions measured 31.2 mm in the longest diameter (range: 18 mm - 50 mm). The sonographic findings were purely solid, heterogeneously hyperechoic and hypovacular for all the cases. The internal architecture revealed a 'layering' appearance (n = 3). The CT findings demonstrated isoattenuation, as compared to the adjacent muscle on both the pre- and postcontrast CT scans. The pathologic correlation demonstrated a characteristic 'organoid' mixture of fibrous, mucoid and fatty tissues in all cases. The diagnosis of FHI can be suggested by the sonographic findings of a superficially located, heterogeneous solid mass with a 'layering' appearance in the fatty layer of the back or arms of infants with local hypertrochosis on the overlying skin.

Rho, Byung Hak; Lee, Hee Jung; Kwon, Sun Young [Dongsan Medical Center, Keimyung University College of Medicine, Daegu (Korea, Republic of)

2009-09-15

244

Briquetting and coking behavior of fibrous xylite  

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Studies laboratory briquetting and coking of wood structured cellulose fiber xylite which makes up 6 to 12% of Miocene brown coal in the GDR. The briquets produced, fibrous in appearance, had high compression strength; the coke compression strength was slightly below the 14 to 18 MPa level of regular brown coal coke. The addition of more than 25% sulfite liquor as binder significantly increased coke strength and density as well as lump coke formation. The possibility of employing xylite for fibrous particleboards in the wood industry is further assessed. Bending strength of xylite briquets pressed with addition of glue and hardener was between 9.8 and 13.5 MPa, furthermore, water resistance of briquets is described as high. Experiments also showed that pressing pressure can be reduced to 75 MPa, without significant losses in bending strength. Size reduction of xylite is regarded as important, i.e. a reduction of xylite particle size from 1.1/0 mm to 0.6/0 mm increases bending strength of briquets by an average of 5 MPa. Graphs of measurement results are provided. 9 refs.

Naundorf, W.; Wollenberg, R.; Cichos, N.

1988-01-01

245

Imaging Findings of Fibrous Hamartoma of Infancy  

International Nuclear Information System (INIS)

We wanted to evaluate the imaging findings of fibrous hamartoma of infancy (FHI). We retrospectively reviewed the clinical presentation and the sonographic (n = 5) and CT (n = 3) findings of 5 cases of surgically/pathologically confirmed FHI. The sonographic findings were evaluated according to the location, size, internal echogenicity and vascularity. The CT findings were evaluated according to the attenuation of the mass on both the pre- (n = 3) and postcontrast (n = 2) scans. The image findings were correlated with the pathologic findings. The mean age was 14.8 months (range, 7 months - 3 years). The location of lesions was all in the fatty layer of the back (n = 4) and upper arm (n = 1). All the lesions demonstrated-hypertrichosis on the overlying skin. The lesions measured 31.2 mm in the longest diameter (range: 18 mm - 50 mm). The sonographic findings were purely solid, heterogeneously hyperechoic and hypovacular for all the cases. The internal architecture revealed a 'layering' appearance (n = 3). The CT findings demonstrated isoattenuation, as compared to the adjacent muscle on both the pre- and postcontrast CT scans. The pathologic correlation demonstrated a characteristic 'organoid' mixture of fibrous, mucoid and fatty tissues in all cases. The diagnosis of FHI can be suggested by the sonographic findings of a superficially located, heterogeneous solid mass with a 'layering' appearance in the fatty layer of the back or arms of infants with local hypertrochosis on the overlying skin

2009-09-01

246

Microscopic observations on some fibrous dust samples  

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Fibers having a diverse range of physical and chemical properties may be emitted into the atmospheric air mostly as a result of human activities. Because the inhalation by man of certain particles may under some circumstances pose a risk to health, this group of particulate matter has to be measured and identified. Because there is little information about the biological (predominantly carcinogenic) potential as yet, measuring techniques are non uniform as well. In this study, the fiber content of human lungdust specimens has been determined electronmicroscopically for 4 different groups: so called normal lungs (as a control), mesothelioma cases, which may have been spontaneous, or initiated by occupational exposure, fibrosis cases (without any lung tumour) after occupational exposure in coal- and talc-mines. In comparison to the mentioned groups some samples from the atmospheric air in the Ruhr District were analyzed for fibers with the aim of obtaining more information about the shape, length and diameter of this particle group. The data indicated that the size distribution of fibrous particles may be highly different depending upon the previous exposure. Furthermore, elongated particles with irregular shapes may confuse the counting and sizing results (preferentially those of the diameters). Based on the present study, fibrous particles greater than 1 micron in length with a length-to-breadth ratio greater than 10: 1 seem to be of increased biological relevance, if mesothelial risk is the main focus of the investigation.

Friedrichs, K.H.; Molik, B.

1985-12-01

247

Self-Organization of Bioinspired Fibrous Surfaces  

Science.gov (United States)

Nature uses fibrous surfaces for a wide range of functions such as sensing, adhesion, structural color, and self-cleaning. However, little is known about how fiber properties enable them to self-organize into diverse and complex functional forms. Using polymeric micro/nanofiber arrays with tunable properties as model systems, we demonstrate how the combination of mechanical and surface properties can be harnessed to transform an array of anchored nanofibers into a variety of complex, hierarchically organized dynamic functional surfaces. We show that the delicate balance between fiber elasticity and surface adhesion plays a critical role in determining the shape, chirality, and hierarchy of the assembled structures. We further report a strategy for controlling the long-range order of fiber assemblies by manipulating the shape and movement of the liquid-vapor interface. Our study provides fundamental understanding of the pattern formation by self-organization of bioinspired fibrous surfaces. Moreover, our new strategies offer a foundation for designing a vast assortment of functional surfaces with adhesive, optical, water-repellent, capture and release, and many more capabilities with the structural and dynamic sophistication of their biological counterparts.

Kang, Sung Hoon

248

Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma  

Science.gov (United States)

Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Hemangiopericytoma; Adult Malignant Mesenchymoma; Adult Neurofibrosarcoma; Adult Rhabdomyosarcoma; Adult Synovial Sarcoma; Gastrointestinal Stromal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Adult Soft Tissue Sarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

2013-12-06

249

Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can be Removed by Surgery  

Science.gov (United States)

Adult Alveolar Soft-part Sarcoma; Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Extraskeletal Chondrosarcoma; Adult Extraskeletal Osteosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma; Adult Liposarcoma; Adult Malignant Fibrous Histiocytoma; Adult Malignant Mesenchymoma; Adult Synovial Sarcoma; Childhood Alveolar Soft-part Sarcoma; Childhood Angiosarcoma; Childhood Epithelioid Sarcoma; Childhood Leiomyosarcoma; Childhood Liposarcoma; Childhood Malignant Mesenchymoma; Childhood Synovial Sarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Stage IB Adult Soft Tissue Sarcoma; Stage IIB Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma

2014-07-01

250

Ceramic-Fibrous-Insulation Thermal-Protection System  

Science.gov (United States)

New composite thermal-protection system developed in which glass-ceramic impregnated into surface of fibrous insulation. Called TUFI for toughened unipiece fibrous insulation developed as replacement for tiles with reaction-cured-glass (RCG) coating. Impregnation of glass-ceramic results in thermal protection system with insulating properties comparable to existing system but with 20 to 100 times more resistance to impact.

Leiser, Daniel; Churchward, Rex; Katvala, Victor; Stewart, David; Balter, Aliza

1992-01-01

251

Marfan syndrome with multiseptate pneumothorax and mandibular fibrous dysplasia  

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We describe a rare case of pneumothorax due to Marfan syndrome associated with fibrous dysplasia of the mandible. Marfan syndrome and fibrous dysplasia were possibly due to a common etiological factor. The association between the two and other tumors described in literature related to Marfan syndrome is discussed.

Kate A; Gothi D; Joshi J

2009-01-01

252

Marfan syndrome with multiseptate pneumothorax and mandibular fibrous dysplasia  

Directory of Open Access Journals (Sweden)

Full Text Available We describe a rare case of pneumothorax due to Marfan syndrome associated with fibrous dysplasia of the mandible. Marfan syndrome and fibrous dysplasia were possibly due to a common etiological factor. The association between the two and other tumors described in literature related to Marfan syndrome is discussed.

Kate A

2009-01-01

253

Fibrous monoliths: Economic ceramic matrix composites from powders [Final report  

Energy Technology Data Exchange (ETDEWEB)

The project was to develop and perform pilot-scale production of fibrous monolith composites. The principal focus of the program was to develop damage-tolerant, wear-resistant tooling for petroleum drilling applications and generate a basic mechanical properties database on fibrous monolith composites.

Rigali, Mark; Sutaria, Manish; Mulligan, Anthony; Creegan, Peter; Cipriani, Ron

1999-05-26

254

Lignitic fibrous xylite as substrate soil; Braunkohlenfaserxylit als Substratboden  

Energy Technology Data Exchange (ETDEWEB)

Substrate soils are used in large quantities for cultivating vegetables, flowers, and ornamental plants in greenhouses as well as for growing trees and shrubs. Peat, coconut fibers as weel as high-grade composts, for example from barks and rice husks, are used primarily for the production of substrate soils. During growth, the substrate soils fulfill essential physical functions such as water and nutrient supply, water storage, soil aeration, and rooting capacity. This article presents the results of tests which were to determine if fibrous xylite from Lausitz lignite could also fulfill these soil functions. Neogene Lausitz lignites contain high proportions of high-grade fibrous xylite. The fibrous xylite has an extensive interstratification with the detritic coal matrix. By means of a special comminution/classification technology, the fibrous xylite is separated in pure form from the coal matrix. The almost coal-free fibrous xylite has many positive properties which lead to the assumption that xylite is suitable as substrate soil. Fibrous xylite's ability to function as a soil modifier has already been reported. Thus, fibrous xylite is a high-grade soil modifier if it is mixed with other soil in proportions of {>=}20 vol.-%. By adding fibrous xylite, the fertility of particularly inefficient soils such as, for example, excavation residue, sandy soil, or limestone soil can be improved significantly. (orig.)

Schroeder, H.W.; Naundorf, W.; Strassburger, U. [Freiberg Univ. of Mining and Technology (Germany)

2005-03-01

255

Electrospun nanocomposite fibrous polymer electrolyte for secondary lithium battery applications  

Science.gov (United States)

Hybrid nanocomposite [poly(vinylidene fluoride -co- hexafluoropropylene) (PVdF-co-HFP)/magnesium aluminate (MgAl2O4)] fibrous polymer membranes were prepared by electrospinning method. The prepared pure and nanocomposite fibrous polymer electrolyte membranes were soaked into the liquid electrolyte 1M LiPF6 in EC: DEC (1:1,v/v). XRD and SEM are used to study the structural and morphological studies of nanocomposite electrospun fibrous polymer membranes. The nanocomposite fibrous polymer electrolyte membrane with 5 wt.% of MgAl2O4 exhibits high ionic conductivity of 2.80 × 10-3 S/cm at room temperature. The charge-discharge capacity of Li/LiCoO2 coin cells composed of the newly prepared nanocomposite [(16 wt.%) PVdF-co-HFP+(5 wt.%) MgAl2O4] fibrous polymer electrolyte membrane was also studied and compared with commercial Celgard separator.

Padmaraj, O.; Rao, B. Nageswara; Jena, Paramananda; Venkateswarlu, M.; Satyanarayana, N.

2014-04-01

256

Fibrous metaphyseal defect (fibrous cortical defect, non-ossifying fibroma). Pt. 2. Differential diagnosis  

Energy Technology Data Exchange (ETDEWEB)

FMD, whether in the stage of a fibrous cortical defect or a non-ossifying fibroma, possesses very characteristic radiological appearances which rarely make it necessary to resort to biopsy. In order to avoid mistakes, it is necessary to observe strictly the known radiological features: metaphyseal position, clearcut relationship to the cortex, well defined margins, maximal size 6 to 7 cm., presence during growth, rarely observed in the upper extremity. The differential diagnosis, which needs to be considered only rarely, is discussed.

Freyschmidt, J.; Ostertag, H.; Saure, D.

1981-04-01

257

Fibrous metaphyseal defect (fibrous cortical defect, non-ossifying fibroma). Pt. 2  

International Nuclear Information System (INIS)

FMD, whether in the stage of a fibrous cortical defect or a non-ossifying fibroma, possesses very characteristic radiological appearances which rarely make it necessary to resort to biopsy. In order to avoid mistakes, it is necessary to observe strictly the known radiological features: metaphyseal position, clearcut relationship to the cortex, well defined margins, maximal size 6 to 7 cm., presence during growth, rarely observed in the upper extremity. The differential diagnosis, which needs to be considered only rarely, is discussed. (orig.)

1981-01-01

258

Nonlinear analysis of laminated fibrous composites  

International Nuclear Information System (INIS)

A computerized analysis of the nonlinear behavior of fibrous composite laminates including axial loading, thermal loading, temperature dependent properties, and edge effects is presented. Ramberg--Osgood approximations are used to represent lamina stress--strain behavior, and percent retention curves are employed to model the variation of properties with temperature. Balanced, symmetric laminates comprised of either boron/epoxy, graphite/epoxy, or borsic--aluminum are analyzed using a quasi-three-dimensional finite element analysis. Results are presented for the interlaminar stress distributions in cross-ply, angle-ply, and more complex laminates. Nonlinear stress--strain curves for a variety of composite laminates in tension and compression are obtained and compared to other existing theories and experimental results

1976-01-01

259

Method of manufacturing fibrous hemostatic bandages  

Energy Technology Data Exchange (ETDEWEB)

A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.

Larsen, Gustavo; Spretz, Ruben; Velarde-Ortiz, Raffet

2012-09-04

260

Symptomatic fibrous lunato-triquetral coalition  

International Nuclear Information System (INIS)

In general, carpal coalitions are considered to be asymptomatic. Incomplete separated joints and associated changes similar to osteoarthritis and pseudoarthrosis are known as possible causes of wrist pain. We present the clinical history, plain-film, and MR imaging findings of two patients with symptomatic fibrous lunato-triquetral coalition. Conventional films disclosed a narrowed space between the lunate and triquetral bone with cysts and sclerosis similar to pseudoarthrosis. Magnetic resonance imaging showed bone marrow edema adjacent to the incomplete separated lunato-triquetral joint and Gd-DTPA enhancing fibrovascular tissue in the synovium and subarticular cysts, explaining the pain over the ulnar-sided wrist. Patients with congenital lunato-triquetral coalition may poorly tolerate stress loading or trauma, resulting in a symptomatic state similar to degenerative arthritis or pseudoarthrosis, which is demonstrated by enhanced MR imaging. (orig.)

1999-10-01

 
 
 
 
261

Symptomatic fibrous lunato-triquetral coalition  

Energy Technology Data Exchange (ETDEWEB)

In general, carpal coalitions are considered to be asymptomatic. Incomplete separated joints and associated changes similar to osteoarthritis and pseudoarthrosis are known as possible causes of wrist pain. We present the clinical history, plain-film, and MR imaging findings of two patients with symptomatic fibrous lunato-triquetral coalition. Conventional films disclosed a narrowed space between the lunate and triquetral bone with cysts and sclerosis similar to pseudoarthrosis. Magnetic resonance imaging showed bone marrow edema adjacent to the incomplete separated lunato-triquetral joint and Gd-DTPA enhancing fibrovascular tissue in the synovium and subarticular cysts, explaining the pain over the ulnar-sided wrist. Patients with congenital lunato-triquetral coalition may poorly tolerate stress loading or trauma, resulting in a symptomatic state similar to degenerative arthritis or pseudoarthrosis, which is demonstrated by enhanced MR imaging. (orig.) With 2 figs., 23 refs.

Staebler, A.; Glaser, C.; Reiser, M. [Department of Diagnostic Radiology, Ludwig Maximilians University of Munich (Germany); Resnick, D. [Department of Radiology, Veterans Administration Medical Center, San Diego, CA (United States)

1999-10-01

262

Fibrous lung tumor: a peculiar case.  

Science.gov (United States)

Solitary fibrous tumor (SFT) of the pleura and the lung is an uncommon spindle cell neoplasm arising from the visceral pleura in the majority of the cases. However there are some extrapleural sites including the lung. Current considerations were raised by a peculiar recent case: an 81-year-old female, no smoker, presented with undefined left thoracic pain. Radiographic findings of a large solid lung mass (10 cm × 9 cm). Computed tomography (CT) confirmed the thoracic mass showing characteristics of a well defined mass with capsule, the position of the mass in proximity of the postero-basal and lateral-basal wall. No secondary lesions were found. Through a left inferior lobectomy and ilo-mediastinal lymph node sampling, the entire mass was resected. Histopathological examination revealed a SFT. In conclusion STF is a rare lesion and this case showed a peculiar extremely large lesion never described before in literature. PMID:23991334

Barrettara, Barbara; Napoli, Gaetano; Lacitignola, Angelo; Sardelli, Paolo

2013-08-01

263

CT features of fibrous dysplasia of the temporal bone  

International Nuclear Information System (INIS)

Fibrous dysplasia is characterized by a progressive replacement of normal bone elements by fibrous tissue. The temporal bone is rarely involved. In this location, complications such as facial deformity, conductive hearing loss and facial peripheral neural involvement can occur. Positive diagnosis can be established with computerized tomography which also enables assessment of extension and detection of complications. We report a case of a 27-year-old man with extensive fibrous dysplasia of the right temporal bone presenting with conductive hearing loss secondary to progressive stenosis of the external auditory canal. Computerized tomography of the temporal region was performed. (authors)

2006-09-01

264

Neuroleptic Malignant Syndrome  

Science.gov (United States)

... Enhancing Diversity Find People About NINDS NINDS Neuroleptic Malignant Syndrome Information Page Table of Contents (click to ... being done? Clinical Trials Organizations What is Neuroleptic Malignant Syndrome? Neuroleptic malignant syndrome is a life-threatening, ...

265

Polyostotic fibrous dysplasia of the ribs: An unusual cause of chest pain and dyspnea  

Directory of Open Access Journals (Sweden)

Full Text Available Sevket Ozkaya1, Serhat Findik2, Hasan Demir1, Canan Yuksel3, Atilla Guven Atici21Samsun Chest Disease and Chest Surgery Hospital, Samsun, Turkey; 2Ondokuz Mayis University, Faculty of Medicine, Department of Pulmonary Medicine, Samsun, Turkey; 3Samsun Pathology and Cytology Centre, Samsun, TurkeyAbstract: Fibrous dysplasia is a benign bony abnormality that may be monostotic or polyostotic and is not included in the differential diagnosis of chest pain and dyspnea, since it is typically asymptomatic. A 36-year-old man presented with left-sided chest pain and dsypnea for three months. Chest X-ray and chest computed tomography scan revealed a large solid mass arising from the anterior parts of the left fourth, fifth, and sixth ribs and compressing the adjacent lung parenchyma. The tumor was completely removed surgically and histopathologic examination was consistent with fibrous dysplasia without malignant transformation. This report demonstrates that polyostotic dysplasia of the ribs may cause chest pain and dyspnea and present radiographically as a large mass.Keywords: chest wall, imaging, computed tomography, thoracotomy

Sevket Ozkaya

2009-08-01

266

Localised fibrous mesothelioma arising in an intralobar pulmonary sequestration.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

A localised fibrous mesothelioma arising from an intralobar lung sequestration occurred in a 64 year old Turkish woman. This appears to be the first report of a mesothelioma occurring within a pulmonary sequestration.

Paksoy, N.; Demircan, A.; Altiner, M.; Artvinli, M.

1992-01-01

267

Ehlers-Danlos syndrome with monostotic fibrous dysplasia  

Directory of Open Access Journals (Sweden)

Full Text Available An unusual case of Ehlers-Danlos syndrome with monostotic fibrous dysplasia of the humorus is presented. The other orthopae-dic manifestations, its complications and associated features are re-viewed and summarised.

Rao A

1979-01-01

268

Solitary fibrous tumor arising in the mesentery: a case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm usually found in the pleura, soft tissues and visceral organs. We describe one case arising in the mesentery, which is an exceptional localization. Case presentation A 71-year-old man was referred to our establishment for a painless hypogastric mass. Further investigation revealed a vascular tumor, which was resected en bloc. Pathological findings confirmed solitary fibrous ...

Bouhabel Sarah; Leblanc Guy; Ferreira Jose; Leclerc Yves E; Dubé Pierre; Sidéris Lucas

2011-01-01

269

Chondrosarcoma occurring in a patient with polyostotic fibrous dysplasia  

International Nuclear Information System (INIS)

A 36-year-old white man with polyostotic fibrous dysplasia was found to have a high-grade chondrosarcoma arising from the left ilium. Although a left hemipelvectomy was performed, the patient subsequently developed sacral and pulmonary metastases and succumbed to his disease. This patient represents the first documented example of an unequivocally high-grade chondrosarcoma arising in an area of fibrous dysplasia without prior irradiation. (orig.)

1981-01-01

270

Localized fibrous mesothelioma of the liver: a case report  

International Nuclear Information System (INIS)

Localized fibrous mesothelioma of the liver is very rare benign tumor. It usually manifest large palpable hepatic mass in right upper quadrant area, and the prognosis is excellent by surgical resection. Contrast enhanced CT scan shows well defined hyperattenuating mass and celiac angiogram shows hypervascular mass. Recently we experienced 1 case of localized fibrous mesothelioma of the liver, and we report CT and angiographic findings of this tumor

1995-10-01

271

Ground-glass pattern fibrous dysplasia of frontal sinus.  

Science.gov (United States)

The case of a 5-year-old boy with ground-glass pattern craniofacial fibrous dysplasia (FD) presenting with progressive swelling in the right frontal region is reported. The imaging findings with computed tomography and magnetic resonance imaging (MRI) findings are presented. The differential diagnosis with inspissated mucocele is discussed as well. Fibrous tissue could be hypo dense on CT. Post-contrast enhancement of the lesion on MRI is the key for diagnosis. PMID:24617184

Chourmouzi, D; Psoma, E; Drevelegas, A

2013-01-01

272

Ultrasonographic features of fibrous hamartoma of infancy  

International Nuclear Information System (INIS)

To review imaging features of fibrous hamartoma of infancy (FHI), focusing on ultrasonography (US) findings. We retrospectively reviewed pediatric patients who were diagnosed with pathologically confirmed FHI in two children's hospitals from 2004 to 2013. Imaging features of US, Doppler US, and magnetic resonance imaging (MRI) were evaluated. Thirteen pediatric patients (M:F = 7:6; age 5-22 months, mean 11.3 months) were included. Mean lesion size was 3.2 cm (range, 0.7-8.0 cm). The tumors were located in the back (n = 4), scrotum (n = 2), scalp, shoulder, axilla, forearm, intergluteal cleft, inguinal area, and thigh. US was performed in 11 patients. With the exception of two scrotal masses, all masses were located in the dermal and subcutaneous layer. All masses demonstrated heterogeneous hyperechogenicity with a ''serpentine pattern'' of intervening hypoechoic portions in the hyperechoic mass. The margins were ill-defined (n = 9) or lobulated (n = 2). Doppler US was performed in nine patients and showed no (n = 6) or minimal (n = 3) vascularity. MRI was performed in five patients and the masses showed heterogeneous signal intensity with the presence of fat on T1- and T2-weighted images. FHI is a tumor that is typically located in the dermal and subcutaneous layer in young children less than 2 years old and presents as a heterogeneously hyperechoic mass with a ''serpentine pattern'' and ill-defined or lobulated margin on US and no remarkable vascularity on Doppler US. (orig.)

2014-05-01

273

Compressibility of air in fibrous materials  

DEFF Research Database (Denmark)

The dynamic compressibility of air in fibrous materials has been computed for two assumed configurations of fibers which are close to the geometry of real fiber materials. Models with parallel cylinders placed in a regular square lattice and placed randomly are treated. For these models the compressibility is computed approximately from the diameter and mean distances between cylinders. This requires calculation of the air temperature, which is calculated for cylinders in a regular lattive by the Wigner-Seitz cell approximation. In the case of random placement, the calculation is done by a summation over thermal waves from all fibers, and by a self-consistent procedure. Figuren of the compressibility in the frequency range 10-100 000 Hz, are given for diameter of the cylinders of 6.8 µm, and mean distances between them from 50 to 110 µm, which corresponds to glass wool with a density of 40 to 16 kg/m3. When the theoretical values for random placement were compared with measurements, it turned out that the random model could not describe the experimental data. However, they could be described accurately by assuming that the fibers have a tendency to form pairs.

Tarnow, Viggo

1996-01-01

274

Intracranial solitary fibrous tumor: Imaging findings  

Energy Technology Data Exchange (ETDEWEB)

Objective: To study the neuroimaging features of intracranial solitary fibrous tumors (ISFTs). Materials and methods: Retrospective study of neuroimaging features of 9 consecutive histopathologically proven ISFT cases. Location, size, shape, density, signal intensity and gadolinium uptake were studied at CT and MRI. Data collected from diffusion-weighted imaging (DWI) (3 patients), perfusion imaging and MR spectroscopy (2 patients), and DSA (4 patients) were also analyzed. Results: The tumors most frequently arose from the intracranial meninges (7/9), while the other lesions were intraventricular. Tumor size ranged from 2.5 to 10 cm (mean = 6.6 cm). They presented multilobular shape in 6/9 patients. Most ISFTs were heterogeneous (7/9) with areas of low T2 signal intensity that strongly enhanced after gadolinium administration (6/8). Erosion of the skull was present in about half of the cases (4/9). Components with decreased apparent diffusion coefficient were seen in 2/3 ISFTs on DWI. Spectroscopy revealed elevated peaks of choline and myo-inositol. MR perfusion showed features of hyperperfusion. Conclusion: ISFT should be considered in cases of extra-axial, supratentorial, heterogeneous, hypervascular tumor. Areas of low T2 signal intensity that strongly enhance after gadolinium injection are suggestive of this diagnosis. Restricted diffusion and elevated peak of myo-inositol may be additional valuable features.

Clarencon, Frederic, E-mail: fredclare5@msn.com [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Bonneville, Fabrice [Department of Neuroradiology, Hopital Rangueil, Toulouse University Hospital, 31000 Toulouse (France); Rousseau, Audrey [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Galanaud, Damien [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France); Kujas, Michele [Department of Neuropathology, Pitie-Salpetriere Hospital (France); Naggara, Olivier [Department of Neuroradiology, St Anne Hospital, 75014 Paris (France); Cornu, Philippe [Department of Neurosurgery, Pitie-Salpetriere Hospital (France); Chiras, Jacques [Department of Neuroradiology, Pitie-Salpetriere Hospital, APHP, 75013 Paris (France)

2011-11-15

275

Treating Fibrous Insulation to Reduce Thermal Conductivity  

Science.gov (United States)

A chemical treatment reduces the convective and radiative contributions to the effective thermal conductivity of porous fibrous thermal-insulation tile. The net effect of the treatment is to coat the surfaces of fibers with a mixture of transition-metal oxides (TMOs) without filling the pores. The TMO coats reduce the cross-sectional areas available for convection while absorbing and scattering thermal radiation in the pores, thereby rendering the tile largely opaque to thermal radiation. The treatment involves a sol-gel process: A solution containing a mixture of transition-metal-oxide-precursor salts plus a gelling agent (e.g., tetraethylorthosilicate) is partially cured, then, before it visibly gels, is used to impregnate the tile. The solution in the tile is gelled, then dried, and then the tile is fired to convert the precursor salts to the desired mixed TMO phases. The amounts of the various TMOs ultimately incorporated into the tile can be tailored via the concentrations of salts in the solution, and the impregnation depth can be tailored via the viscosity of the solution and/or the volume of the solution relative to that of the tile. The amounts of the TMOs determine the absorption and scattering spectra.

Zinn, Alfred; Tarkanian, Ryan

2009-01-01

276

Anisotropic fibrous scaffolds for articular cartilage regeneration.  

Science.gov (United States)

Articular cartilage lesions, which can progress to osteoarthritis, are a particular challenge for regenerative medicine strategies, as cartilage function stems from its complex depth-dependent microstructural organization, mechanical properties, and biochemical composition. Fibrous scaffolds offer a template for cartilage extracellular matrix production; however, the success of homogeneous scaffolds is limited by their inability to mimic the cartilage's zone-specific organization and properties. We fabricated trilaminar scaffolds by sequential electrospinning and varying fiber size and orientation in a continuous construct, to create scaffolds that mimicked the structural organization and mechanical properties of cartilage's collagen fibrillar network. Trilaminar composite scaffolds were then compared to homogeneous aligned or randomly oriented fiber scaffolds to assess in vitro cartilage formation. Bovine chondrocytes proliferated and produced a type II collagen and a sulfated glycosaminoglycan-rich extracellular matrix on all scaffolds. Furthermore, all scaffolds promoted significant upregulation of aggrecan and type II collagen gene expression while downregulating that of type I collagen. Compressive testing at physiological strain levels further demonstrated that the mechanical properties of trilaminar composite scaffolds approached those of native cartilage. Our results demonstrate that trilaminar composite scaffolds mimic key organizational characteristics of native cartilage, support in vitro cartilage formation, and have superior mechanical properties to homogenous scaffolds. We propose that these scaffolds offer promise in regenerative medicine strategies to repair articular cartilage lesions. PMID:22655795

McCullen, Seth D; Autefage, Hélène; Callanan, Anthony; Gentleman, Eileen; Stevens, Molly M

2012-10-01

277

Simulation and Analysis of Unbonded Nonwoven Fibrous Structures  

Directory of Open Access Journals (Sweden)

Full Text Available In this work we report on our algorithm for generating 3-D virtual structures resembling un-bonded fibrous webs. The paper discusses short and infinitely long fibers, each emulating a category of nonwoven fibrous medium. The structure Solid Volume Fraction (SVF, being the most important characteristic of a fibrous porous medium, is calculated for different fiberwebs and discussed in details. It is shown that the SVF of the fibrous structures generated by our algorithm is independent of the basis weight. In other words, the porosity of the medium is only a function of the fiber properties – this is as expected. It is also demonstrated that by decreasing the fiber diameter while keeping other properties of the virtual fiberweb constant causes the SVF to decrease almost linearly. The same is not observed for the fiber rigidity. The capability of our algorithm for generating fibrous webs made up of layers of different fibers is demonstrated and their properties are discussed. The application of such virtual fibrous structures in modeling transport phenomena in nonwoven materials and their potential applications in load-deformation studies are discussed.

Behnam Pourdeyhimi

2006-11-01

278

Morphogenesis of the fibrous sheath in the marsupial spermatozoon.  

Science.gov (United States)

The spermatozoon fibrous sheath contains longitudinal columns and circumferential ribs. It surrounds the axoneme of the principal piece of the mammalian sperm tail, and may be important in sperm stability and motility. Here we describe its assembly during spermiogenesis in a marsupial, the brush-tail possum, and compare its structural organization with that of eutherian mammals, birds and reptiles. Transmission electron microscopy showed that possum fibrous sheath assembly is a multistep process extending in a distal-to-proximal direction along the axoneme from steps 4 to 14 of spermiogenesis. For the most part, assembly of the longitudinal columns occurs before that of the circumferential ribs. Immunohistochemical and immunogold labelling showed that fibrous sheath proteins are first present in the spermatid cytoplasm; at least some of the proteins of the sheath precursors differ from those in the mature fibrous sheath. That immunoreactivity develops after initiation of chromatin condensation suggests that fibrous sheath proteins, or their mRNAs, are stored within the spermatid cytoplasmic lobule prior to their assembly along the axoneme. These findings are similar to those in laboratory rats, and thus suggests that the mode of fibrous sheath assembly evolved in a common ancestor over 125 million years ago, prior to the divergence of marsupial and eutherian lineages. PMID:16050902

Ricci, M; Breed, W G

2005-08-01

279

Malignant hyperthermia  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Malignant hyperthermia (MH is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stresses such as vigorous exercise and heat. The incidence of MH reactions ranges from 1:5,000 to 1:50,000–100,000 anesthesias. However, the prevalence of the genetic abnormalities may be as great as one in 3,000 individuals. MH affects humans, certain pig breeds, dogs, horses, and probably other animals. The classic signs of MH include hyperthermia to marked degree, tachycardia, tachypnea, increased carbon dioxide production, increased oxygen consumption, acidosis, muscle rigidity, and rhabdomyolysis, all related to a hypermetabolic response. The syndrome is likely to be fatal if untreated. Early recognition of the signs of MH, specifically elevation of end-expired carbon dioxide, provides the clinical diagnostic clues. In humans the syndrome is inherited in autosomal dominant pattern, while in pigs in autosomal recessive. The pathophysiologic changes of MH are due to uncontrolled rise of myoplasmic calcium, which activates biochemical processes related to muscle activation. Due to ATP depletion, the muscle membrane integrity is compromised leading to hyperkalemia and rhabdomyolysis. In most cases, the syndrome is caused by a defect in the ryanodine receptor. Over 90 mutations have been identified in the RYR-1 gene located on chromosome 19q13.1, and at least 25 are causal for MH. Diagnostic testing relies on assessing the in vitro contracture response of biopsied muscle to halothane, caffeine, and other drugs. Elucidation of the genetic changes has led to the introduction, on a limited basis so far, of genetic testing for susceptibility to MH. As the sensitivity of genetic testing increases, molecular genetics will be used for identifying those at risk with greater frequency. Dantrolene sodium is a specific antagonist of the pathophysiologic changes of MH and should be available wherever general anesthesia is administered. Thanks to the dramatic progress in understanding the clinical manifestation and pathophysiology of the syndrome, the mortality from MH has dropped from over 80% thirty years ago to less than 5%.

Pollock Neil

2007-04-01

280

A call to expand regulation to all carcinogenic fibrous minerals  

Science.gov (United States)

The regulatory term "asbestos" groups only the six fibrous minerals that were commercially used among approximately 400. The carcinogenicity of these six regulated minerals has been largely demonstrated and is related to fiber structure, fiber length/diameter ratio, and bio-persistence. From a public perception, the generic term "asbestos" refers to the fibrous minerals that cause asbestosis, mesothelioma and other cancers. However, other non-regulated fibrous minerals are potentially as dangerous as the regulatory asbestos because they share similar physical and chemical properties, epidemiological studies have demonstrated their relationship with asbestos-related diseases, and both in vitro and in vivo experiments have established the toxicity of these minerals. For example, the non-regulated asbestiform winchite and richterite minerals that contaminated the vermiculite mined from Libby, Montana, (USA) were associated with mesothelioma, lung cancer and asbestosis observed among the area's residents and miners. Many other examples of non-regulated carcinogenic fibrous minerals include, but are not limited to, antigorite, arfvedsonite, balangeroite, carlosturanite, erionite, fluoro-edenite, hornblende, mordenite, palygorskite, and sepiolite. To propose a regulatory definition that would provide protection from all carcinogenic fibers, we have conducted an interdisciplinary literature review to compare the characteristics of "asbestos" and of non-regulated mineral fibers that relate to carcinogenicity. We specifically studied two non-regulated fibrous minerals that are associated with asbestos-related diseases: the serpentine antigorite and the zeolite erionite. Both examples underscore the problem of regulation based on commercial, rather than scientific principles: 1) the occurrence of fibrous antigorite in materials used to pave roads has been correlated with high mesothelioma rates in New Caledonia. Antigorite was also the cause of asbestosis in Poland, and in vitro and in vivo studies have shown its toxic and carcinogenic properties; 2) the carcinogenic properties of erionite have been demonstrated, and erionite has been associated with a mesothelioma epidemic in Anatolia, Turkey. Erionite is also widespread in areas of north central USA, where it is contained in gravel paving stone, and is cause for concern due to increased commercial traffic. Numerous studies have shown that non-regulated fibrous materials pose similar health hazards to regulated "asbestos". An increase in human activities in areas where these fibrous minerals are present, such as in surficial rock and soil, will result in the generation of airborne dust, exposing people to carcinogenic fibers. The current limited regulation leads people to believe that only the six mineral fibers referred to as "asbestos" are dangerous. We propose that fibrous minerals should be regulated as a single group, as they have similar deleterious effects on the human body. Regulations would be simplified and more effective if they embrace all carcinogenic fibrous minerals.

Baumann, F.; Steele, I.; Ambrosi, J.; Carbone, M.

2013-05-01

 
 
 
 
281

Unusual causes of spinal foraminal widening.  

Science.gov (United States)

Spinal neural foraminal widening is usually caused by benign lesions, most commonly neurofibromas. Rare lesions can also cause spinal neural foraminal widening. Computed tomography and/or MRI are the modalities of choice for studying the spinal foraminal widening. The present pictorial review describes six rare lesions, namely a lateral thoracic meningocele, a malignant fibrous histiocytoma, a tuberculous abscess, an osteoblastoma, a chondrosarcoma and a malignant tumour of the lung which caused spinal neural foraminal widening. PMID:10663733

Zibis, A H; Markonis, A; Karantanas, A H

2000-01-01

282

A Pulmonary Infarction Mimicking Metastatic Lung Tumor  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Pulmonary infarction may present as a solitary pulmonary nodule resembling a malignant pulmonary tumor. A 71-year-old woman who had undergone the surgery for abdominal malignant fibrous histiocytoma (MFH) with inflammatory nature presented with a small nodule in the right lung in computed tomographic images. Two months later, the nodule became enlarged and had an accompanying infiltrative shadow. We suspected a metastatic tumor from MFH and performed video-assisted thoracic surgery. However, ...

2011-01-01

283

Ultrasonographic features of fibrous hamartoma of infancy  

Energy Technology Data Exchange (ETDEWEB)

To review imaging features of fibrous hamartoma of infancy (FHI), focusing on ultrasonography (US) findings. We retrospectively reviewed pediatric patients who were diagnosed with pathologically confirmed FHI in two children's hospitals from 2004 to 2013. Imaging features of US, Doppler US, and magnetic resonance imaging (MRI) were evaluated. Thirteen pediatric patients (M:F = 7:6; age 5-22 months, mean 11.3 months) were included. Mean lesion size was 3.2 cm (range, 0.7-8.0 cm). The tumors were located in the back (n = 4), scrotum (n = 2), scalp, shoulder, axilla, forearm, intergluteal cleft, inguinal area, and thigh. US was performed in 11 patients. With the exception of two scrotal masses, all masses were located in the dermal and subcutaneous layer. All masses demonstrated heterogeneous hyperechogenicity with a ''serpentine pattern'' of intervening hypoechoic portions in the hyperechoic mass. The margins were ill-defined (n = 9) or lobulated (n = 2). Doppler US was performed in nine patients and showed no (n = 6) or minimal (n = 3) vascularity. MRI was performed in five patients and the masses showed heterogeneous signal intensity with the presence of fat on T1- and T2-weighted images. FHI is a tumor that is typically located in the dermal and subcutaneous layer in young children less than 2 years old and presents as a heterogeneously hyperechoic mass with a ''serpentine pattern'' and ill-defined or lobulated margin on US and no remarkable vascularity on Doppler US. (orig.)

Lee, Seungsoo; Kim, Myung-Joon; Lee, Mi-Jung [Yonsei University College of Medicine, Department of Radiology and Research Institute of Radiological Science, Severance Children' s Hospital, Seoul (Korea, Republic of); Choi, Young-Hun; Cheon, Jung-Eun [Seoul National University Children' s Hospital, Department of Radiology, Seoul (Korea, Republic of); Koh, Myoung Ju [Yonsei University College of Medicine, Department of Pathology, Seoul (Korea, Republic of)

2014-05-15

284

Recurring fibrous dysplasia of anthro maxillary with cranial base invasion  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Fibrous dysplasia is an osseous lesion with an unknown etiology. It is characterized by the osseous maturation insufficiency. It may affect any bone, but the affection of craniofacial bones is the most critical for otorhinolaryngology. Maxilla is the most affected facial bone and the orbitary invasion is an uncommon event. The symptoms are unspecific and for its low suspicion and uncommonness, the diagnosis is generally late. The monostotic form presents a slow growth and asymptomatic course and needs to be followed up. The polyostotic type has a progressive behavior and is associated to recurrence and complications. Objective: To present two cases of patients with fibrous dysplasia diagnosis and describe the clinical presentation, radiological findings and the treatment of this pathology. Cases Report: Two cases of fibrous dysplasia are reported, which initially presented unspecific symptomatology, but with characteristic radiologic signs. They were submitted to surgical treatment for resection of the lesions and evolved with frequent recurrences with extensive affection of the facial sinuses, one patient had cranial base invasion and frontal craniotomy was needed for tumoral excision. Final Comments: Fibrous dysplasia is an uncommon osteopathy. The tomography is the choice method for characterization of the tumoral expansion, and helps in the surgical planning. The surgical strategy is indicated for symptomatic lesions, functions alterations or anatomic disorders. This article describes two uncommon manifestations of recurrent fibrous dysplasia with an extensive affection of anthro maxillary, ethmoidal and sphenoid sinuses, in addition to orbitary and cranial base invasion.

Sousa, Kátia Maria Marabuco de

2009-09-01

285

Fibrous monolithic ceramics: 1. Fabrication, microstructure, and indentation behavior  

International Nuclear Information System (INIS)

Monolithic ceramics have been fabricated from coated green fibers to create fibrous microstructures. The fibrous monoliths consist of high aspect ratio polycrystalline regions (cells) of a primary phase separated by thin second-phase regions (cell boundaries) designed to improve fracture resistance. The cells are the remnants of the green fiber which consists of ceramic powder and a polymer binder. The coating applied on the green fiber forms the cell boundaries. Fabrication and microstructure are described for fibrous monoliths in the SiC/graphite, silicon nitride/BN, alumina/alumina-zirconia, alumina/aluminum titanate, alumina/nickel and Ce-TZP/alumina-Ce-zirconia systems. The SiC/graphite fibrous monolith displays noncatastrophic failure in flexure, with shear delamination along the weak graphite layers. Indentations in SiC/graphite cause cells to spall, with crack arrest and extrusion of graphite from the cell boundaries. Crack deflection and spalling of cells are also observed in alumina/alumina-zirconia fibrous monoliths. In the Ce-TZP/alumina system, transformed regions around indentations are significantly modified by the alumina-containing cell boundaries

1993-09-01

286

Pseudotumor fibroso paratesticular / Paratesticular fibrous pseudotumor  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivos: Los procesos proliferativos benignos testiculares se conocen con el nombre de pseudotumors, al no ser considerados en la actualidad verdaderas neoplasias. El Pseudotumor Fibroso Paratesticular (PFP) es una entidad sobre las que existe gran confusión en su definición y etiopatogenia. Se tr [...] ata de un proceso que confunde al clínico al aparecer simulando neoplasias. La presente comunicación puede ayudar a conocer mejor este proceso no tumoral y evitar confusiones diagnósticas. Métodos/Resultados: Revisamos nuestra serie de PFP (tres casos) sobre esta rara entidad, por lo que dada su rareza puede considerarse significativa. Analizamos su clínica, su comportamiento antes los estudios diagnósticos por imagen, hallazgos operatorios y evolución. Conclusiones: El PFP es una rara entidad que puede confundir al clínico al ser diagnosticado como una neoplasia, y conllevar tratamientos agresivos (orquiectomía) que de realizar un exacto diagnóstico podrían obviarse. El análisis de una serie de tres casos, con sus aportaciones, y la revisión de la literatura efectuada pueden ayudar en la practica clínica al urólogo a reconocer esta enfermedad. Abstract in english Objective: Benign testicular proliferative processes are known by the name of pseudotumors, because currently they are not considered real neoplasias. The paratesticular fibrous pseudotumor (PFP) is a rare entity, the definition and etiopathogenesis of which is under great confusion. It is a process [...] that misleads the clinical because they simulate neoplasias. This paper aims to help a better knowledge of this non-tumoral process and to avoid diagnostic confusions. Methods/Results: We review our series of PFP (three cases), which can be considered significant due to its oddity. We analyze the clinical picture, its behavior, imaging diagnostic tests, operative findings and outcomes. Conclusions: PFP is a rare entity which may misleads the clinical because it may be diagnosed as a neoplasia and lead to aggressive treatment (orchiectomy) which in case of a proper diagnosis could be avoided. The analysis of our series of three cases, with their contribution, and a literature review may help the clinical practice of urologists by recognizing this disease.

López Aramburu, Miguel Ángel; Viguri Díaz, Amparo; Peña Pérez, Pablo; Rosa Arias, José; Saiz Camin, Mónica.

287

Polyostotic Fibrous Dysplasia of Cranio-Maxillofacial Area  

International Nuclear Information System (INIS)

Fibrous dysplasia is believed to be a hamartomatous developmental lesion of unknown origin. This disease is divided into monostotic and polyostotic fibrous dysplasia. Polyostotic type can be divided into craniofacial type, Lichtenstein-Jaffe type, and McCune-Albright syndrome. In this case, a 31-year-old female presented spontaneous loss of right mandibular teeth before 5 years and has shown continuous expansion of right mandibular alveolus. Through the radiographic view, the coarse pattern of the mixed radiopaque-lucent lesion was seen on the right mandibular body, and there was diffuse pattern of the mixed radiopaque-lucent lesion with ill-defined margin in the left mandibular body. In the right calvarium, the lesion had cotton-wool appearance. Partial excision for contouring, multiple extraction, and alveoloplasty were accomplished under general anesthesia for supportive treatment. Finally we could conclude this case was polyostotic fibrous dysplasia of cranio-maxillofacial area based on the clinical, radiologic finding, and histopathologic examination.

2000-06-01

288

Efficacy of trabectedin in metastatic solitary fibrous tumor  

Directory of Open Access Journals (Sweden)

Full Text Available Solitary fibrous tumor is a rare tumor type and has an unpredictable course. Local recurrence rate varies between 9 and 19 %, and rate of metastatic involvement between 0 and 36 %. It is characterized by a typical architecture and immuno-histochemistry tests. The most important prognostic factor is the complete resection of primary tumor. Treatment of recurrences is not clearly established. If a solitary fibrous tumor is too advanced to allow surgical resection, radiotherapy and chemotherapy may be used. The most often used drugs are doxorubicine andor ifosfamide. We report the case of man with metastatic solitary fibrous tumor treated with trabectedin, administered at a dose of 1.5 mg/m² every 3 weeks. After 3 cycles, metastases had significantly decreased. Recurrence of the disease was demonstrated 8 months after the start of trabectedin. This case shows that trabectedin is a possible treatment option.

Xavier Pivot

2011-07-01

289

Natural, forced and mixed convection in fibrous insulation  

International Nuclear Information System (INIS)

A numerical solution of flow and temperature distribution in fibrous insulation has been obtained. Rectangular and cylindrical geometries have been modeled. Boundary conditions included permeable hot wall and convective heat transfer at the walls. Good agreement has been obtained with published experimental and numerical values on rectangular cavities. The computed velocity and temperature profiles gave a better understanding of flow and heat transfer phenomena in fibrous insulation. Local cold wall and average Nusselt numbers presented, provide useful information in the design of the fibrous insulation for concrete reactor vessel and primary coolant piping of the gas cooled nuclear power plants. Average Nusselt number has been correlated with Rayleigh number when only natural convection is present, and with Rayleigh and Reynolds numbers when a combination of natural and forced convection is present

1978-01-01

290

Structural characteristics, dispersion, and modification of fibrous brucite  

Science.gov (United States)

Fibrous brucite has very unique structure and physical properties. Brucite fibers were exfoliated into single nanofibers by using dioctyl sodium sulfosuccinate (AOT) as a dispersant through mechanical agitation and ultrasonic dispersion; and then, the nanofibers were modified by stearic acid and (3-aminopropyl)triethoxysilane (?-APS) compound modification agent. The nanofibers were characterized by using X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermal gravimetric analysis. It is found that AOT has good effect on the dispersion. The single fiber has a consistent morphology, and fibrous brucite is dispersed and modified without destroying the crystal structure. Infrared and thermal analysis shows that the surface modification of fibrous brucite is achieved by forming chemical bonds between the coupling agent and magnesium hydroxide.

Cao, Xi; Chuan, Xiu-yun

2014-01-01

291

Magnetoelectric effects in multiferroic fibrous composite with imperfect interface  

International Nuclear Information System (INIS)

This paper investigates the magnetoelectroelastic responses of multiferroic fibrous composites with imperfectly bonded interface under longitudinal shear. The proposed imperfect interface model is a natural generalization of the shear lag (or the spring layer) model. By virtue of the complex variable method, we first consider the case where an isolated circular multiferroic fiber is imperfectly bonded to an infinite multiferroic matrix. Very concise expressions for the complex field potentials characterizing the magnetoelectroelastic fields inside and outside the circular fiber are obtained when the matrix is subjected to the remote uniform magnetoelectroelastic loading. The Mori-Tanaka mean-field method is then employed to derive the effective moduli of the multiferroic fibrous composite made of randomly distributed fibers reinforced to the matrix. Particularly we demonstrate that the interfacial imperfection in elasticity, electricity, and magnetism will always cause a significant reduction in the magnetoelectric coefficient of the BaTiO3-CoFe2O4 fibrous composite

2007-12-01

292

Polyostotic Fibrous Dysplasia of Cranio-Maxillofacial Area  

Energy Technology Data Exchange (ETDEWEB)

Fibrous dysplasia is believed to be a hamartomatous developmental lesion of unknown origin. This disease is divided into monostotic and polyostotic fibrous dysplasia. Polyostotic type can be divided into craniofacial type, Lichtenstein-Jaffe type, and McCune-Albright syndrome. In this case, a 31-year-old female presented spontaneous loss of right mandibular teeth before 5 years and has shown continuous expansion of right mandibular alveolus. Through the radiographic view, the coarse pattern of the mixed radiopaque-lucent lesion was seen on the right mandibular body, and there was diffuse pattern of the mixed radiopaque-lucent lesion with ill-defined margin in the left mandibular body. In the right calvarium, the lesion had cotton-wool appearance. Partial excision for contouring, multiple extraction, and alveoloplasty were accomplished under general anesthesia for supportive treatment. Finally we could conclude this case was polyostotic fibrous dysplasia of cranio-maxillofacial area based on the clinical, radiologic finding, and histopathologic examination.

Han, Jin Woo; Kwon, Hyuk Rok; Lee, Jin Ho; Park, In Woo [Dept. of Oral and Maxillofacial Radiology, College of Dentistry, Kangnung National University, Kangnung (Korea, Republic of)

2000-06-15

293

Spatial variability of void structure in thin stochastic fibrous materials  

CERN Multimedia

Theory is presented for the distributions of local process intensity and local average pore dimensions in random fibrous materials. For complete partitioning of the network into contiguous square zones, the variance of local process intensity is shown to be proportional to the mean process intensity and inversely proportional to the zone size. The coefficient of variation of local average pore area is shown to be approximately double that of the local average pore diameter with both properties being inversely proportional to the square root of zone size and mean process intensity. The results have relevance to heterogenous near-planar fibrous materials including paper, nonwoven textiles, nanofibrous composites and electrospun polymer fibre networks.

Sampson, William W

2011-01-01

294

Plasticity analysis of fibrous composite laminates under thermomechanical loads  

Science.gov (United States)

Elastic-plastic behavior of fibrous composite laminates is analyzed for coupled in-plane mechanical loads and uniform thermal changes. Constitutive equations of the individual fibrous layers are derived from a vanishing fiber diameter model that represents the essential axial constraint between the phases. This permits derivation of closed form equations for the overall yield condition, stress concentration factors, and instantaneous compliance. Thermoelastic properties of the phases and yield stress of the matrix phase are functions of temperature. The effect of the model assumptions on the predicted behavior of composite laminates is examined by comparing the calculated response under cyclic thermal changes to available theoretical results and experimental measurements.

Bahei-El-din, Yehia A.

1990-01-01

295

Focal Electroencephalography Rhythm Asymmetry due to Focal Skull Fibrous Dysplasia  

Science.gov (United States)

An unusual pervasive and persistent asymmetry in background rhythm was found on surface electroencephalography (EEG) recordings in a 22 year old with new onset of generalized seizure activity. Radiographic correlation with computed tomography, positron emission tomography and bone scan imaging uncovered that the higher amplitude left frontal-parietal background activity was related to a circumscribed area of left frontal-parietal fibrous dysplasia affecting the skull. This case report emphasizes that the presumed higher electrical conductance of fibrous dysplasia lead to a greater transparency of normal background rhythms, and must be taken into account as a form of breach rhythm for accurate EEG interpretation

Meyer, Michael A.

2014-01-01

296

Functional, malignant intrathoracic paraganglioma.  

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This paper describes a case of functional, malignant branchiomeric paraganglioma, the third such to be reported. The patient presented with malignant hypertension and symptoms suggestive of excessive catecholamine secretion.

Aggarwal, P.; Wali, J. P.; Venugopal, P.; Khosla, A.; Tickoo, S. K.

1989-01-01

297

Malignant teratoma (image)  

Science.gov (United States)

A malignant teratoma is a type of cancer consisting of cysts that contain one or more of the three ... embryonic germ layers: ectoderm, mesoderm, and endoderm. Because malignant teratomas have usually spread by the time of ...

298

Consideraciones actuales en hiperplasia fibrosa inflamatoria / Current considerations in inflammatory fibrous hyperplasia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish El objetivo de esta investigación es evaluar los aspectos clínicos, histológicos y las posibilidades de tratamiento de la hiperplasia fibrosa inflamatoria (HFI). Esta lesión se origina frecuentemente a partir de prótesis totales o parcial mal adaptadas, las cuales generan un traumatismo crónico de b [...] aja intensidad. Se han descrito lesiones en mandíbula y maxila, no existiendo predilección por ninguna de las arcadas dentales. Lesiones pequeñas pueden ser tratadas de manera conservadora, con remoción del agente causal o mediante atrofia por presión con nuevas prótesis, mientras que lesiones extensas y de larga evolución necesitarán de escisión quirúrgica. Si el tratamiento quirúrgico es considerado, éste debe incluir la remoción total de la lesión, usando diversas técnicas como bisturí “frío” (lámina), láser o electrocirugía.La remoción quirúrgica es necesaria, pues restaura el contorno normal del tejido y la adaptación protética. Algunos autores han reportado alteraciones displásicas en la HFI, pero la posibilidad de que ésta sufra una transformación maligna aún es muy discutida. Abstract in english The objective of this research is an evaluate of clinical and histologic aspects of fibrous inflammatory hyperplasia and the possibilities of its treatment. This lesion is frequently originated for using total or partial prosthesis which are inadequate adapted generating a chronic traumatism of low [...] intensity. Clinical cases in jaw and maxila have been reported, not existing predilection for any dental arches. Small lesions can be treated by the conservative way that means removing the causal agent or atrophying by putting pressure with a new prosthesis, whereas extensive lesions of large evolution need surgical excision. If the surgical treatment is considered, this should include the total removal of the lesion, using varieties of techniques such as “cold” scalpel, laser or electrosurgical techniques. The surgical removal is necessary because recover the normal contour of tissue and the prosthetic adaptation. reports exist about dysplasic alterations related to fibrous inflammatory hyperplasia, but the possibility of a malignant transformation is actually controversial.

Jose luis, Muñante-Cárdenas; Jaimes, Miguel; Olate, Sergio; José Ricardo, Albergaria-Barbosa.

299

Fibrous dysplasia complicated by aneurysmal bone cyst formation affecting multiple cervical vertebrae  

International Nuclear Information System (INIS)

Fibrous dysplasia is a well-known benign dysplastic process of bone. However, fibrous dysplasia is very uncommon in the spine. Further, to our knowledge, co-existence of fibrous dysplasia and aneurysmal bone cyst in the spine has not been reported. This manuscript presents a patient who had both processes involving the cervical spine. (orig.)

2003-09-01

300

Localized fibrous tumor of the liver: imaging findings  

International Nuclear Information System (INIS)

We report the imaging of a localized fibrous tumor of the liver, focusing on color Doppler US, CT, MR imaging, and angiographic findings. We discuss the differential diagnosis of such a rare, benign lesion of the liver. Detailed imaging of this tumor has not been reported in the literature previously. (orig.)

1998-02-01

 
 
 
 
301

Balloon catheder dilatation of experimental fibrous renal artery stenosis  

International Nuclear Information System (INIS)

Two models with fibrous renal artery stenoses were developed in order to study the effects of balloon catheter dilatation. In one, chromic catgut was used for subtotal ligation of the renal artery; in the other anastomoses of the renal artery were deliberately stenosed. The results of dilatation were evaluated by angiography and microscopic examination at different intervals after angioplasty. (orig.)

1982-01-01

302

DEVELOPMENT AND FABRICATION OF A PROTOTYPE FIBROUS AEROSOL MONITOR (FAM)  

Science.gov (United States)

This report describes a program whose objective was to develop, design, fabricate and laboratory-test two prototype instruments capable of real-time selective detection and measurement of airborne fibrous-shaped particles. The selective detection of the fibers is effected by sync...

303

Failure Regimes in (1+1)d in Fibrous Materials  

CERN Document Server

In this work, we introduce a model for fracture in fibrous materials which take into account the rupture height of the fibers, in contrast with previous models. Thus, we obtain the profile of the fracture and calculate its roughness, defined as the variance around the mean height. We investigate the relationship between the fracture roughness and the fracture toughness.

Menezes-Sobrinho, I L; Moreira, J G

2001-01-01

304

Ultrasonographic Localization of Solitary Fibrous Tumor of Pleura: Case Report  

Energy Technology Data Exchange (ETDEWEB)

Plain radiography and computed tomography are widely used in the field of chest disease. Yet ultrasonography has a limitation as a diagnostic tool, except in the case of pleural effusion and chest wall lesion. We experienced a case of solitary fibrous tumor of the diaphragmatic pleura, and the origin of this tumor could be exactly localized by ultrasonography, but not by other imaging modalities

Kim, Kyoung Tae; Jeon, Yong Sun; Cho, Soon Gu; Kim, Kwang Ho; Lee, Kyung Hee [Inha University School of Medicine, Incheon (Korea, Republic of)

2010-03-15

305

Mesenchymal chondrosarcoma arising in fibrous dysplasia of the femur.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The occurrence of mesenchymal chondrosarcoma in an area of fibrous dysplasia in the upper femur of a 28 year old man is reported. It is believed that this is the first documented example of such an association. A further unusual feature is the presence of benign giant cells in the mesenchymal chondrosarcomatous component.

Blackwell, J. B.

1993-01-01

306

An improved automotive brake lining using fibrous potassium titanate  

Science.gov (United States)

Simultaneous fade reduction and wear improvement of a commercial automotive brake lining were achieved by adding fibrous potassium titanate. The dependence of friction and wear characteristics on quantitative variations in potassium titanate, asbestos, phenolic binder, and organic and inorganic modifiers was evaluated.

Mansfield, J. A.; Halberstadt, M. L.; Riccitiello, S. R.; Rhee, S. K.

1976-01-01

307

Examination of compression and resilience characteristics of fibrous insulation blankets  

International Nuclear Information System (INIS)

Load-deflection characteristics of alumina and alumino-silicate fibrous blankets were experimentally determined. Load retention and springback capability of combinations of these materials were measured in a 10,000-hour test at surface temperatures of 650 to 10000C (1200 to 18320F). Experimental results are presented and future testing plans are discussed

1979-10-26

308

Malignant mesothelioma : An experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation  

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Malignant mesothelioma is a highly aggressive tumor with median survival ranging from 4 to 12 months and, despite intense therapeutical efforts, it is invariably fatal. Mesothelioma cells are unique in the sense that they possess a biphasic growth potential and can be stimulated by serum growth factors to differentiate into stable epithelial or fibrous phenotypes. The prognosis of this tumor varies greatly depending on the differences in growth pattern, the most important pr...

Dobra, Katalin

2002-01-01

309

Diagnostic validity of the osteoscintigraphy in some non-malignant diseases and fractures of maxillofacial bones  

International Nuclear Information System (INIS)

In 37 patients with non-malignant diseases or bone fractures of the facial skull 42 osteoscintigraphies were accomplished with /sup 99m/Te labelled 1-hydroxyethylidene-1,1-diphosphonate or /sup 99m/Te labelled methylenediphosphonate. In patients with polyostotic bone diseases such as fibrous osteodysplasia or eosinophilous granuloma it proved more favorable concerning lower radiation doses to perform scintigraphy prior to radiography. (author)

1984-01-01

310

Differences in lectin binding of malignant pleural mesothelioma and adenocarcinoma of the lung.  

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In order to differentiate between malignant pleural mesothelioma and adenocarcinoma of the lung, the glycoconjugate profiles of 6 reactive mesothelial lesions, 23 mesotheliomas (17 epithelial, 1 desmoplastic, 2 biphasic, and 3 fibrous types), and 28 well-differentiated pulmonary adenocarcinomas were evaluated with the use of 8 lectins in addition to anti-carcinoembryonic, anti-keratin and anti-epithelial membrane antigen. Formalin-fixed, paraffin-embedded tissues were stained with the avidin-...

1988-01-01

311

Desmoplastic malignant mesothelioma of the pericardium: Description of a case and review of the literature  

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Desmoplastic mesothelioma (DMM) is a rare and highly lethal subtype of diffuse malignant mesothelioma and is often difficult to distinguish from reactive pleural fibrosis. The term “desmoplastic” refers to the growth of fibrous or connective tissue. We report the clinical, radiological, and pathological features of a primary DMM of the pericardium and a short review of the literature. A 72-year-old man was admitted presenting shortness of breath, cough, and asthenia. Computed tomography s...

Nicolini, Antonello; Perazzo, Alessandro; Lanata, Sergio

2011-01-01

312

Pediatric malignancies presenting as a possible infectious disease  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The clinical, laboratory, and radiological features of malignancy can overlap with those of infection. The purpose of this study was to determine the findings in children who were initially thought to have an infectious disease but ultimately proved to have a malignancy. Methods The database of patients diagnosed with a malignancy in the Northern Alberta Children's Cancer Program (NACCP January 1, 1993 to December 31, 2003 was merged with the database of inpatients referred to the infectious diseases service at the Stollery Children's Hospital and charts were reviewed on all patients referred to the infectious diseases consult service prior to the diagnosis of malignancy. Results An infectious diseases consultation for diagnosis was requested in 21 of 561 patients prior to the confirmation of malignancy, and 3 of these 21 patients had both infection and malignancy (leukemia (N = 13, lymphoma (N = 3, rhabdomyosarcoma (N = 1, Langerhan's cell histiocytosis (N = 1, fibrous histicocytosis (N = 1, ependymoma (N = 1, and neuroblastoma (N = 1. The most common reason for infectious diseases consultation was suspected muskuloskeletal infection (N = 9. A palpable or radiographically enlarged spleen was noted in 11 patients (52%. All but 2 patients had abnormal hematologic parameters while an elevated lactate dehydrogenase (LDH occurred in 10 patients (48%. Delay of diagnosis because of investigation or therapy for an infectious disease occurred in only 2 patients. Conclusion It is not common for treatment of pediatric malignancies to be delayed because infection is thought to be the primary diagnosis. However, pediatric infectious diseases physicians should consider malignancy in the differential diagnosis when they see patients with fever and bone pain, unexplained splenomegaly or abnormal complete blood cell counts. Other clues may include hepatomegaly or elevated LDH.

Robinson Joan L

2007-05-01

313

Calcifying fibrous tumour originating from the right cardiac ventricle in a child.  

Science.gov (United States)

Calcifying fibrous tumour is a rare benign fibrous lesion. It is paucicellular, with fibroblasts, dense collagenisation, psammomatous and dystrophic calcification, and patchy lymphoplasmacytic infiltrates. Calcifying fibrous tumour was first described in subcutaneous and deep soft tissues, and has been reported all over the body. However, calcifying fibrous tumour originating from the heart is extremely rare. This article describes the case of a giant calcifying fibrous tumour arising from the right ventricle in a child, where the tumour was totally resected and no recurrence was observed during a 4-year follow-up period. PMID:23391107

Zhang, Ben; Zhang, Weida; Wang, Xiaowu

2014-02-01

314

Rare primary malignant tumors of the liver. Tumeurs malignes primitives rares du foie  

Energy Technology Data Exchange (ETDEWEB)

Angiosarcoma, epithelioid hemangio-endothelioma (EHE) and fibrolamellar carcinoma (FLC) are far less frequent malignant primary tumors of the liver than liver-cell carcinoma, and usually do not occur in a chronic liver disease. Their diagnosis is histological but a few radiological criteria are suggestive: in younger subjects, a solitary, hypervascularized mass containing calcifications and/or a central fibrous scar suggests an FLC; nodular lesions merging into patches, scattered about the periphery, containing calcified clusters and showing a low and late contrast enhancement after injections suggest an EHE; lastly, in case of occupational exposure, an heterogeneous, hypervascularized mass with a centripetal blush but containing central areas that are opacified early should suggest angiosarcoma. (4 figs).

Dahan, H.; Zoppardo, P.; Chagnon, S.; Vilgrain, V.; Blery, M. (Hopital Lariboisiere, 75 - Paris (FR))

1991-01-01

315

Natural convection heat transfer in a rectangular enclosure containing various wastes of fibrous materials  

Energy Technology Data Exchange (ETDEWEB)

The applicability of various fibrous wastes such as textile fabrics, non-woven fabrics, fishing net and so on as insulating materials in the enclosure containing liquid was investigated and the heat transfer rates were measured in the differentially heated enclosure filled with various fibrous wastes and pure water. The void ratio in the enclosure with various fibrous wastes was varied in the wide range. The permeability of fibrous wastes was also measured to discuss the heat transfer rate in detail. It is clarified here that the configuration of the fibrous waste affects largely on the heat transfer rate. Namely, the sheet-type waste can suppress the heat transfer rate largely in comparison with the case of cord-type waste under the condition of constant void ratio. Moreover, it is cleared here that the configuration of the fibrous wastes affects the permeability of the wastes and that the heat transfer rate largely depends on the permeability of fibrous wastes.

Noto, Kiyuki; Kimura, Teruo; Takeuchi, Masanori; Nagai, Niroh

1999-07-01

316

Pedunculated malignant melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available Pedunculated malignant melanoma is a rare occurrence. A 29 year old woman presented with a pedunculated malignant melanoma on a congenital melanocytic naevus with halo. Pedunculated malignant melanoma is known to have a high incidence of metastasis. The absence of metastasis and the presence of halo, in the case presented, suggests, that the body?s immunological process may have arrested the spread of the melanoma.

Bhat Ramesha

1994-01-01

317

Pedunculated malignant melanoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Pedunculated malignant melanoma is a rare occurrence. A 29 year old woman presented with a pedunculated malignant melanoma on a congenital melanocytic naevus with halo. Pedunculated malignant melanoma is known to have a high incidence of metastasis. The absence of metastasis and the presence of halo, in the case presented, suggests, that the body?s immunological process may have arrested the spread of the melanoma.

Bhat Ramesha; Sachidanand, S.; Stephen John

1994-01-01

318

Malignant Proliferating Trichilemmal Tumor  

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Proliferating trichilemmal tumor (PTT) is a benign tumor originating from the outer root sheath of a hair follicle. Malignant transformation in case of PTT is very rare and unusual finding. It is usually confused with squamous cell carcinoma both sharing many common features. So the identification of malignant PTT is very essential. Only 39 well-documented cases of malignant proliferating trichilemmal cyst have been published to date in the English language literature. We hereby present a cas...

Goyal, Snigdha; Jain, Bhawna Bhutoria; Jana, Sritanu; Bhattacharya, Subodh K.

2012-01-01

319

Growth hormone and malignancy.  

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The finding of raised growth hormone concentrations in patients with secondary malignancy in the liver is reported. These concentrations were significantly higher than those found in patients with primary malignancy only or in those with non-hepatic secondaries. A wide range of malignancies was investigated and the high growth hormone concentration was not specific for any type of tumour. This suggested that the increased hormone was not the product of the tumour cells but due to altered live...

Andrews, G. S.

1983-01-01

320

Malignant focal liver lesions; Maligne fokale Leberlaesionen  

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Focal liver lesions are a very common occurrence. The detection and differentiation of such lesions is particularly important for the management of oncology patients and is a core task for radiology. The early and conclusive detection of malignant liver processes in a cost-efficient manner and with a low radiation dose for the patient requires systematic and skillful use of the various radiological methods. This review explains the application of current radiological methods for the detection and differentiation of malignant liver lesions and the typical appearance of the most commonly found liver malignancies. (orig.) [German] Fokale Leberlaesionen sind eine sehr haeufige Entitaet. Die Detektion und Differenzierung solcher Laesionen ist insbesondere fuer das onkologische Patientenmanagement von groesster Wichtigkeit und stellt eine der zentralsten Aufgaben der Radiodiagnostik dar. Die fruehe und sichere Erkennung maligner Leberprozesse bei hoher Kosteneffizienz und niedriger Strahlendosis erfordert einen systematischen Einsatz der verschiedenen Bildgebungstechniken. Der vorliegende Beitrag erlaeutert den Einsatz gaengiger radiologischer Verfahren zur Detektion und Differenzierung maligner Leberlaesionen und deren typisches Erscheinungsbild. (orig.)

Moritz, T.; Prosch, H.; Ba-Ssalamah, A. [Allgemeines Krankenhaus, Medizinische Universitaet Wien, Univ.-Klinik fuer Radiodiagnostik, Wien (Austria); Schuster, H. [Wilhelminenspital Wien, Institut fuer Diagnostische und Interventionelle Radiologie, Wien (Austria)

2011-08-15

 
 
 
 
321

Rheumatic Diseases and Malignancies  

Science.gov (United States)

ABSTRACT There are many studies which demonstrate a higher risk for malignancy in patients with rheumatic diseases. There have been a number of possible explanations for the differences in the risk of certain malignancies in patients with rheumatic disease, compared with general population, but a clear mechanism is difficult to identify. Rheumatoid syndromes may be associated with malignancy as paraneoplastic conditions, which can antedate the neoplasm diagnosis. On the other hand, autoimmune rheumatic diseases have a higher risk of malignancy by themselves or because of the immunosuppressant treatments.

BOJINCA, Violeta; JANTA, Iustina

2012-01-01

322

Fibrous protein-based hydrogels for cell encapsulation.  

Science.gov (United States)

Tissue scaffolds play a vital role in tissue engineering by providing a native tissue-mimicking environment for cells, with the aim to promote cell proliferation, proper cell differentiation, and regeneration. To better mimic the microenvironment of native tissues, novel techniques and materials have emerged in recent years. Among them, hydrogels formed from self-assembled biopolymer networks are particularly interesting. This paper reviews the fabrication and use of fibrous protein-based hydrogels, with an emphasis on silk, keratin elastin and resilin proteins. Hydrogels formed by these proteins show close structural, chemical and mechanical similarities with the extracellular matrix, typically good biological compatibility, and they can trigger specific cellular responses. In addition, these hydrogels can be degraded in the body by proteolytic enzymes. For these reasons, fibrous protein hydrogels are one of the most versatile materials for tissue engineering. PMID:24836951

Silva, Raquel; Fabry, Ben; Boccaccini, Aldo R

2014-08-01

323

Thermal Performance Experiment for Sintered Aluminum Fibrous Heat Sink  

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This paper is concerned with the thermal performances and frictional characteristics for sintered aluminum fibrous heat sink. The results obtained experimentally include the effect of fiber diameter, porosity and air flow velocity on the thermal performance. The experimental results were compared with the previous studies such as results for an aluminum foam heat sink and results for a copper fibrous layer. The relations between Nusselt number (NuD) and pumping power characteristics (Cfp•ReD3) were very sensitive to fiber diameter (dw) and these are expressed in following equations, NuD=28.26(Cfp •ReD3 •10-10)0.188 in the case of dw=0.14 mm,NuD=46.35(Cfp•ReD3•10-10)0.139 in the case of dw=0.54 mm, respectively.

Komatsu, Yoshimi; Sugawara, Masahiro; Sato, Kansai; Fujita, Tadashi

324

The surgical management of fibrous dysplasia of bone  

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Full Text Available Abstract The surgical management of Polyostotic Fibrous Dysplasia (FD of bone is technically demanding. The most effective methods to manage the associated bone deformity remain unclear. The marked variation in the degree and pattern of bone involvement has made it difficult to acquire data to guide the surgeon’s approach to these patients. In light of the paucity of data, but need for guidance, recognized experts in the management of these patients came together at the National Institutes of Health in Bethesda, Maryland as part of an International meeting to address issues related to fibrous dysplasia of bone to discuss and refine their recommendations regarding the surgical indications and preferred methods for the management of these challenging patients. The specific challenges, recommended approaches, and “lessons learned” are presented in hopes that surgeons faced with typical deformities can be guided in the surgical reconstruction of both children and adults with FD.

Stanton Robert P

2012-05-01

325

Interaction of ruby laser with carbon fibrous materials  

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Full Text Available Carbon fibrous materials are interesting because of their good properties and numerous possible applications. The characteristics of these materials can be programmed by careful selection of the modification process parameters. The laser technique can be successfully employed for these purposes. The high temperatures arising in the material during a short laser pulse can cause a number of changes in the material. Carbon fibrous materials with different textile shapes, during different stages of processing, were exposed to laser radiation. A ruby laser (X=694.3 nm was used to modify the material. The structural changes were examined by scanning electron microscopy and X-ray diffraction. It was established that the radiation of this laser induces structural changes leading to a better arrangement of the turbostratic carbon fiber structure.

Staši? Jelena M.

2007-01-01

326

Intramuscular solitary fibrous tumor: a clinicopathological case study.  

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We present a case of extrapleural solitary fibrous tumor arising within the muscle, an unusual and hitherto-undescribed tumor lesion. A 42-year-old woman presented a painless mass in her left thigh. The lesion was depicted as an intramuscular mass that enhanced on both CT and MRI, showing quite rich tumor vascularity. The histological features of the tumor were spindle cell proliferation with various histological patterns, typical fibrocollagenous background, and positive immunoreactivity for CD-34. PMID:10348456

Abe, S; Imamura, T; Tateishi, A; Park, P; Nakano, H; Harasawa, A; Hashimoto, H; Matsushita, T

1999-01-01

327

The surgical management of fibrous dysplasia of bone  

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Abstract The surgical management of Polyostotic Fibrous Dysplasia (FD) of bone is technically demanding. The most effective methods to manage the associated bone deformity remain unclear. The marked variation in the degree and pattern of bone involvement has made it difficult to acquire data to guide the surgeon’s approach to these patients. In light of the paucity of data, but need for guidance, recognized experts in the management of these patients came together at the National ...

2012-01-01

328

The Surgical Management of Fibrous Dysplasia of Bone  

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The surgical management of Polyostotic Fibrous Dysplasia (FD) of bone is technically demanding. The most effective methods to manage the associated bone deformity remain unclear. The marked variation in the degree and pattern of bone involvement has made it difficult to acquire data to guide the surgeon’s approach to these patients. In light of the paucity of data, but need for guidance, recognized experts in the management of these patients came together at the National Institutes of Healt...

2012-01-01

329

The surgical management of fibrous dysplasia of bone  

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The surgical management of Polyostotic Fibrous Dysplasia (FD) of bone is technically demanding. The most effective methods to manage the associated bone deformity remain unclear. The marked variation in the degree and pattern of bone involvement has made it difficult to acquire data to guide the surgeon’s approach to these patients. In light of the paucity of data, but need for guidance, recognized experts in the management of these patients came together at the National Institutes of Healt...

2012-01-01

330

Electrospun Fibrous Scaffolds with Multi-scale and Photopatterned Porositya  

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The structural and mechanical properties of tissue engineered environments are crucial for successful cellular growth and tissue repair. Electrospinning is gaining wide attention for the fabrication of tissue engineered scaffolds, but the small pore sizes of these scaffolds limit cell infiltration and construct vascularization. To address this problem, we have combined electrospinning with photopatterning to create multi-scale porous scaffolds. This process retains the fibrous nature of the s...

Sundararaghavan, Harini G.; Metter, Robert B.; Burdick, Jason A.

2010-01-01

331

Gastric calcifying fibrous tumor removed by endoscopic submucosal dissection  

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The World Health Organization describes calcifying fibrous tumors (CFTs) as rare, benign lesions characterized by hypocellular, densely hyalinized collagenization with lymphoplasmacytic infiltration. These tumors rarely involve the gastrointestinal (GI) tract. A routine endoscopic upper gastrointestinal screen detected a 10-mm submucosal tumor (SMT) in the lesser curvature of the lower corpus of the stomach of an apparently healthy, 37-year-old woman with no history of Helicobacter pylori inf...

2013-01-01

332

Oral Calcifying Fibrous Pseudotumor: Case Analysis and Review  

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Calcifying fibrous pseudotumor (CFT) is a rare distinct soft-tissue lesion characterized histologically by lymphoplasmacytic aggregates in a rich collagenized background with abundant psammomatous and dystrophic calcifications. Occurring most often in children and young adults, CFTs are clinically benign lesions that can form over a broad anatomic distribution, including in subcutaneous and deep soft tissues, as well as in serosal and visceral locations. The cause and mechanisms of pathogenes...

2008-01-01

333

Imaging findings of calcifying fibrous tumour of the liver  

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Calcifying fibrous tumour (CFT) is a recently recognised rare benign lesion characterised by dense hyalinised collagenous tissue, psammomatous or dystrophic calcifications and a lymphoplasmacytic infiltrate. The usual locations of the lesion are the soft tissues of the extremities, but rarely it occurs in the abdomen. Recently, we experienced a case of CFT found in the liver of a 29-year-old woman. Here, we describe the characteristic radiological and histopathological findings, along with a ...

2011-01-01

334

Nutritional fibrous osteodystrophy in goats Osteodistrofia fibrosa nutricional em caprinos  

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Seven out of 25 goats from a southern Brazilian flock developed nutritional fibrous osteodystrophy. Affected animals were younger than 1 year of age and were confined in stalls and fed a concentrate ration containing 1:6 calcium:phosphorus ratio. The remaining flock (35 goats) was managed at pasture and showed no disease. Clinical signs were characterized by mandibular and maxillary enlargements, varying degrees of mouth opening and protruding tongue, dyspnea, apart of abnormalities of prehen...

2011-01-01

335

Carbon-based fibrous EDLC capacitors and supercapacitors  

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This paper investigates electrochemical double-layer capacitors (EDLCs) including two alternative types of carbon-based fibrous electrodes, a carbon fibre woven fabric (CWF) and a multiwall carbon nanotube (CNT) electrode, as well as hybrid CWF-CNT electrodes. Two types of separator membranes were also considered. An organic gel electrolyte PEO-LiCIO4-EC-THF was used to maintain a high working voltage. The capacitor cells were tested in cyclic voltammetry, charge-discharge, and impedance test...

Lekakou, C.; Moudam, O.; Markoulidis, F.; Andrews, T.; Watts, J. F.; Reed, G. T.

2011-01-01

336

Recurring fibrous dysplasia of anthro maxillary with cranial base invasion  

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Introduction: Fibrous dysplasia is an osseous lesion with an unknown etiology. It is characterized by the osseous maturation insufficiency. It may affect any bone, but the affection of craniofacial bones is the most critical for otorhinolaryngology. Maxilla is the most affected facial bone and the orbitary invasion is an uncommon event. The symptoms are unspecific and for its low suspicion and uncommonness, the diagnosis is generally late. The monostotic form presents a slow growth and asympt...

2009-01-01

337

Elastic-plastic behavior of non-woven fibrous mats  

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Electrospinning is a novel method for creating non-woven polymer mats that have high surface area and high porosity. These attributes make them ideal candidates for multifunctional composites. Understanding the mechanical properties as a function of fiber properties and mat microstructure can aid in designing these composites. Further, a constitutive model which captures the membrane stress-strain behavior as a function of fiber properties and the geometry of the fibrous network would be a powerful design tool. Here, mats electrospun from amorphous polyamide are used as a model system. The elastic-plastic behavior of single fibers are obtained in tensile tests. Uniaxial monotonic and cyclic tensile tests are conducted on non-woven mats. The mat exhibits elastic-plastic stress-strain behavior. The transverse strain behavior provides important complementary data, showing a negligible initial Poisson's ratio followed by a transverse:axial strain ratio greater than -1:1 after an axial strain of 0.02. A triangulated framework has been developed to emulate the fibrous network structure of the mat. The micromechanically based model incorporates the elastic-plastic behavior of single fibers into a macroscopic membrane model of the mat. This representative volume element based model is shown to capture the uniaxial elastic-plastic response of the mat under monotonic and cyclic loading. The initial modulus and yield stress of the mat are governed by the fiber properties, the network geometry, and the network density. The transverse strain behavior is linked to discrete deformation mechanisms of the fibrous mat structure including fiber alignment, fiber bending, and network consolidation. The model is further validated in comparison to experiments under different constrained axial loading conditions and found to capture the constraint effect on stiffness, yield, post-yield hardening, and post-yield transverse strain behavior. Due to the direct connection between microstructure and macroscopic behavior, this model should be extendable to other electrospun systems and other two dimensional random fibrous networks.

Silberstein, Meredith N.; Pai, Chia-Ling; Rutledge, Gregory C.; Boyce, Mary C.

2012-02-01

338

Total hip replacement for proximal femoral tumours: our midterm results  

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Data from 44 patients (23 males, 21 females) with a median age of 39 (range 13–80) years who underwent total hip arthroplasty for proximal femoral tumours (1994–2004) were analysed. The histological diagnoses included 14 metastases, six osteosarcomas, six chondrosarcomas, four Ewing’s sarcomas, four giant cell tumours, three malignant fibrous histiocytomas, two parosteal and two periosteal osteosarcomas, and one each primary neuroectodermal tumour, myeloid disease, and aneurysmal bone ...

2006-01-01

339

Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiation-induced high-grade breast sarcoma  

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This article is a case report of a high grade, radio-induced, breast malignant fibrous histiocytoma (undifferentiated high grade pleomorphic sarcoma), which developed in a 44-year old female, seven years after breast conservative surgery and radiotherapy for a T1N0M0 invasive left breast ductal carcinoma. The sarcoma presented as a fast growing tumour, 9.5 cm in the largest diameter, with skin, left breast, chest wall muscle and rib invasion.

Quadros, Claudio Almeida; Vasconcelos, Alessandro; Andrade, Roque; Ramos, Roge?rio Santos; Studart, Eduardo; Nascimento, Geraldo; Trajano, Andre?

2006-01-01

340

Dedifferentiated Liposarcoma in the Retroperitoneum in an Atomic Bomb Survivor: Report of a Case  

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A 76-year-old Japanese man was admitted to Kosei-Nenkin Hospital (Osaka, Japan) in November 2006; his chief complaint was a 10-kg loss in body weight over 3 months prior to admission. Abdominal computed tomography (CT) and dynamic magnetic resonance imaging (MRI) showed three masses in the retroperitoneum. The patient subsequently underwent surgery. The final histopathological diagnosis of tumors 1 and 2 was malignant fibrous histiocytoma of the retroperitoneum, and tumor 3 was a well-differe...

2008-01-01

 
 
 
 
341

Intraoperative radiotherapy (IORT) combined with external beam radiotherapy (EBRT) for soft-tissue sarcomas – a retrospective evaluation of the Homburg experience in the years 1995–2007  

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Abstract Purpose To retrospectively evaluate the results after a regimen of surgery, IORT (intraoperative radiotherapy), and EBRT (external beam radiotherapy) for soft-tissue sarcomas Methods 38 consecutive patients underwent IORT for soft-tissue sarcoma; 29 were treated for primary tumours, 9 for recurrences. There were 14 cases with liposarcomas, 8 with leiomyosarcomas, 7 with malignant fibrous histiocytomas. 27/38 tumours were located in the extremities, the ...

2009-01-01

342

Case for diagnosis Caso para diagnóstico  

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Atypical fibroxanthoma is a rare cutaneous tumor found mainly in elderly people on sun-exposed areas of the body. Histologically, atypical fibroxanthoma is considered a malignant fibrous histiocytoma with bizarre neoplastic cells, marked pleomorphism, hyperchromatic nuclei and abundant mitoses. It must be differentiated from other skin tumors, usually by immunohistochemistry, since its diagnosis is made by exclusion.O fibroxantoma atípico é um tipo de neoplasia cutânea maligna rara, en...

Mariana Hammerschmidt; Luciana Menezes de Azevedo; Anelisa Ruaro; Betina Werner; Alexandre do Nascimento; Ézio Augusto Amaral Filho

2012-01-01

343

Tumor fibroso solitário do rim: descrição de caso Solitary fibrous tumor of the kidney: a case report  

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Full Text Available Apresentamos um caso de tumor renal num paciente de 27 anos de idade, que foi submetido a estudo de imagem por tomografia computadorizada e ressonância magnética. As características radiológicas da massa induziam para um diagnóstico de tumor renal maligno de origem intraparanquimatosa. No entanto, o estudo histopatológico revelou tumor fibroso solitário benigno originário da pelve e porção calicial do rim direito.We present a case of a 27-year-old male patient submitted to computed tomography and magnetic resonance imaging for the evaluation of a renal tumor. The radiological features of the mass suggested the diagnosis of a malignant renal tumor of parenchymatous origin. However, the histological findings proved to be a benign solitary fibrous tumor within the pelvis and caliceal portion of the right kidney.

Giovani Rodrigues Batista

2005-08-01

344

Study on the soft tissue uptake of "9"9"mTc-methylene diphosphonate  

International Nuclear Information System (INIS)

Authors enumerate various malignant and benign cases which showed soft tissue uptake of "9"9"mTc-MDP. We hope it might be a help in understanding and interpreting bone scans. Among 10,361 "9"9"mTc-MDP bone scans underwent from April, 1981 to March, 1986, 344(3.3%) showed abnormal soft tissue uptake, which included 126 malignancies, 5 benign turmors, and 153 nontumorous diseases. Neuroblastoma(23.3%) and malignant fibrous histio-cytoma(22.2%) showed highest positive uptake rate among various malignancies. We also illustrated typical cases according to possible mechanisms. (Author)

1986-01-01

345

Hypoxiradiotherapy of malignant tumors  

International Nuclear Information System (INIS)

Experience in hypoxyradiotherapy (HRT) of malignant tumors, conducted in the USSR within the framework of the All-Union Scientific program Modifier is generalized. Results of HRT of malignant tumors including larynx, stomach, mammary gland cancer are considered. Advantages of HRT are indicated

1988-01-01

346

Malignent diseases in childhood  

International Nuclear Information System (INIS)

As malignant diseases in childhood are rare, and only a small group of radiotherapists have been able to gain experience in this field, this chapter treats the particularities of childhood from this aspect. The side effects of radiotherapy are particularly important here for the growing and developing organism of the child. The most frequently occuring malignant diseases are treated individually. (MG)

1980-01-01

347

Primary ovarian malignant melanoma  

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Full Text Available Background. Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies. Case report. We presented a case of primary ovarian malignant melanoma in a 45- year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors. Conclusion. Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.

Kostov Miloš

2010-01-01

348

Solitary Fibrous Tumor in the Round Ligament of the Liver: A Fortunate Intraoperative Discovery  

Science.gov (United States)

Solitary fibrous tumors (SFTs) are mesenchymal neoplasms of fibroblastic origin, most commonly found in the pleura. Numerous extrathoracic locations have been reported during the last 2 decades. Herein, we report the first case of an SFT in the round ligament of the liver. A 46-year-old Caucasian man presented with a 12-month history of abdominal pain. An ultrasonography-guided microbiopsy first revealed a desmoid tumor. After failure of first- and second-line medical treatments (celecoxib and tamoxifen, then imatinib), histological reexamination was suspicious for a low-grade sarcoma. MRI was also suspicious for a malignant process. Hence, surgery was decided. Laparotomy found a huge and well-limited tumor that, unexpectedly, was appended to the round ligament of the liver and free from any other intra-abdominal contact. The tumor was easily removed. Excision was monobloc and macroscopically complete. Histological analysis diagnosed an SFT arising from the round ligament of the liver. No adjuvant treatment was given. Ten months after surgery, the patient is alive without any signs or symptoms of relapse. This is the first report of SFT arising from the round ligament of the liver. It illustrates the difficulty in diagnosing such tumors. Whilst diagnosis of SFT is rare, it should be kept in mind to allow early diagnosis and complete surgical resection, which provide the best chance for recovery.

Beyer, Laura; Delpero, Jean-Robert; Chetaille, Bruno; Sarran, Anthony; Perrot, Delphine; Moureau-Zabotto, Laurence; Guiramand, Jerome; Bertucci, Francois

2012-01-01

349

Intramuscular myxoma and fibrous dysplasia of bone - Mazabraud`s syndrome  

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We present a case of Mazabroud`s syndrome, a rare benign disease, with multiple intramuscular myxomas of the thoracic wall associated with fibrous dysplasia of bone. CT, MR imaging and ultrasonography (US) of the thorax showed 2 well circumscribed homogeneous intramuscular tumors. A US-guided needle biopsy with a large-core needle (2.0 mm) and a fine needle (0.8 mm) showed that the tumors were intramuscular myxomas with no sign of malignancy. {sup 99m}Tc bone scintigraphy showed a markedly increased uptake in the right lower skull, and multiple smaller foci. CT of the skull revealed a right-sided unilateral bone thickening of the orbit and the ethomoidal cells, and right-sided exophthalmia. This case history suggests that patients with multiple intramuscular myxomas should be preoperatively examined for osseous lesions. A postoperative follow-up should also be performed to detect other soft-tissue myxomas not as yet clinically detectable, or rare osseous complications. (orig.).

Court-Payen, M. [Copenhagen Univ. (Denmark). Dept. of Ultrasound; Ingemann Jensen, L. [Copenhagen Univ. (Denmark). Dept. of Radiology; Bjerregaard, B. [Copenhagen Univ. (Denmark). Dept. of Pathology; Schwarz Lausten, G. [Copenhagen Univ. (Denmark). Dept. of Orthopedics; Skjoldbye, B. [Copenhagen Univ. (Denmark). Dept. of Ultrasound

1997-05-01

350

Enzyme histochemical study on bone tumors.  

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Full Text Available A total of 19 cases with bone tumors, including six osteosarcomas. three giant cell tumors of bone, one malignant fibrous histiocytoma, four nonossifying fibromas, four chondromas and one chondrosarcoma, were examined as to enzyme histochemistry; the enzymes consisted of alkaline phosphatase (ALPase, acid phosphatase (ACPase, nonspecific esterase (NSE, adenosine triphosphatase (ATPase, 5'-nucleotidase (5'-Nucl and beta-glucuronidase (beta-Gl. Osteosarcoma was strongly positive for ALPase followed by 5'-Nucl. Giant cell tumor, malignant fibrous histiocytoma and nonossifying fibroma showed enzyme histochemistry similar to each other: multinucleated giant cells and round cells in these tumors were strongly positive for ACPase, NSE, ATPase and 5'-Nucl simulating osteoclasts and histiocytes, whereas spindle cells were positive for ATPase and 5'-Nucl in their cytoplasm and weakly positive for ACPase. Chondroma and chondrosarcoma were focally positive for ACPase and NSE; the ACPase was sensitive to tartaric acid treatment. These observations showed that ALPase activity is very characteristic to osteosarcoma, and is useful for its diagnosis. From enzyme histochemistry, giant cell tumor, malignant fibrous histiocytoma and nonossifying fibroma can be regarded as a histiocyte-derived tumor of bone in contrast to osteosarcoma and cartilaginous tumors.

Yoshida,Haruhiko

1982-12-01

351

Radiation Therapy for Malignant Mesothelioma  

Science.gov (United States)

... malignant mesothelioma Next Topic Chemotherapy for malignant mesothelioma Radiation therapy for malignant mesothelioma Radiation therapy uses high- ... this form of treatment more useful. Uses of radiation therapy Radiation therapy may be used in different ...

352

Malignant proliferating trichilemmal tumor.  

Science.gov (United States)

Proliferating trichilemmal tumor (PTT) is a benign tumor originating from the outer root sheath of a hair follicle. Malignant transformation in case of PTT is very rare and unusual finding. It is usually confused with squamous cell carcinoma both sharing many common features. So the identification of malignant PTT is very essential. Only 39 well-documented cases of malignant proliferating trichilemmal cyst have been published to date in the English language literature. We hereby present a case of a 75-year-old female patient with a rapidly growing swelling on the scalp. PMID:22470211

Goyal, Snigdha; Jain, Bhawna Bhutoria; Jana, Sritanu; Bhattacharya, Subodh K

2012-01-01

353

Solitary fibrous tumor with giant multinucleated cells in the retroperitoneum - a case report  

Science.gov (United States)

Context: Solitary fibrous tumor is a distinct neoplasm, rarely recognized in extrathoracic sites. Case report: The article reports a new case in the retroperitoneum in a 55 year-old man, who presented with urinary symptoms. Tumor was completely excised, and the solitary fibrous tumor was diagnosed after pathologic examination and immunohistochemistry. The patient has remained free of disease for five years since surgery. Conclusion: An uncommon variant of retroperitoneal solitary fibrous tumor with giant multinucleated cells was documented in the study.

Trabelsi, Amel; Hammedi, Faten; Rammeh, Soumaya; Abdelkrim, Soumaya Ben; Yacoub-Abid, Lilia Ben; Beizig, Nadia; Sriha, Badreddine

2009-01-01

354

Experimental characterization and modeling of the permeability of fibrous preforms using gas for direct processes application.  

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A methodology to measure in-plane permeability of fibrous media using a transient one dimensional air flow is developed. The method, based on the measurement of gas pressure at the boundaries throughout the transient flow, is convenient, clean and fast, avoids usage of a gas flow meter and offers a way to study the gas transport within fibrous media. The gas transport through fibrous porous media is described by several models to comply with different flow regimes. The permeability, only depe...

Hou, Yi

2012-01-01

355

Solitary fibrous tumor with giant multinucleated cells in the retroperitoneum - a case report  

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Context: Solitary fibrous tumor is a distinct neoplasm, rarely recognized in extrathoracic sites. Case report: The article reports a new case in the retroperitoneum in a 55 year-old man, who presented with urinary symptoms. Tumor was completely excised, and the solitary fibrous tumor was diagnosed after pathologic examination and immunohistochemistry. The patient has remained free of disease for five years since surgery. Conclusion: An uncommon variant of retroperitoneal solitary fibrous tum...

Amel Trabelsi; Faten Hammedi; Soumaya Rammeh; Soumaya Ben Abdelkrim; Lilia BenYacoub-Abid; Nadia Beïzig; Badreddine Sriha

2009-01-01

356

Mineral inclusions in fibrous diamonds: constraints on cratonic mantle refertilization and diamond formation  

Science.gov (United States)

We analyzed mineral microinclusions in fibrous diamonds from the Wawa metaconglomerate (Superior craton) and Diavik kimberlites (Slave craton) and compared them with published compositions of large mineral inclusions in non-fibrous diamonds from these localities. The comparison, together with similar datasets available for Ekati and Koffiefontein kimberlites, suggest a general pattern of metasomatic alteration imposed on the ambient mantle by formation of fibrous diamond. Calcium and Fe enrichment of peridotitic garnet and pyroxenes and Fe enrichment of olivine associated with fibrous diamond-forming fluids contributes to refertilization of the cratonic mantle. Saline—carbonatitic—silicic fluid trapped by fibrous diamonds may represent one of the elusive agents of mantle refertilization. Calcium enrichment of peridotitic garnet and pyroxenes is expected in local mantle segments during fibrous diamond production, as Ca in the carbonatitic fluids is deposited into the surrounding mantle when oxidized carbon is reduced to diamond. Harzburgitic garnet evolves towards Ca-rich compositions even when it interacts with Ca-poor saline fluids. An unusual trend of Mg enrichment to Fo95-98 is observed in some olivine inclusions in Wawa fibrous diamonds. The trend may result from the carbonatitic composition of the fluid that promotes crystallization of magnesian olivine and preferentially oxidizes the fayalite component. We propose a generic model of fibrous and non-fibrous diamond formation from carbonatitic fluids that explains enrichment of the mantle in mafic magmaphile and incompatible elements and accounts for locally metasomatized compositions of diamond inclusions.

Miller, Christine E.; Kopylova, Maya; Smith, Evan

2014-06-01

357

Malignant primary pulmonary paraganglioma.  

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The histological, immunocytochemical, and electron microscopic findings in a case of malignant primary pulmonary paraganglioma are reported. The existence of this rare tumour is evidence for the presence of pulmonary chemoreceptors.

Hangartner, J. R.; Loosemore, T. M.; Burke, M.; Pepper, J. R.

1989-01-01

358

MALIGNANT EXTERNAL OTITIS  

Directory of Open Access Journals (Sweden)

Full Text Available Two case reports of malignant external otitis in the elderly diabetics and their complications and management with regard to our experience at Amir Alam Hospital, Department of ENT will be discussed here.

Massoud Moghaddam

1993-06-01

359

Familial malignant retroperitoneal paraganglioma.  

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Paragangliomas are neuroendocrine tumours and those occurring in the head and neck have well recognized familial association. Retroperitoneal paragangliomas are uncommon and we present two cases of familial malignant retroperitoneal paraganglioma. Review of the literature revealed marked differences in the incidence and malignant potential of familial and non-familial paraganglioma. In contrast to the cases reported here, familial tumours are generally benign, though they may occur at multipl...

Sebastian, J. P.; Williams, S. E.; Wells, M.; Peake, M. D.

1989-01-01

360

Disseminated malignant melanoma  

Directory of Open Access Journals (Sweden)

Full Text Available A 25-year-old man had multiple asymptomatic, nodular lesions on the trunk, extremities and the face for 3 months. He also had left facial palsy with severe headache and vomiting. There were no other systemic or constitutional symptoms. Skin biopsy from a nodular lesion showed features of malignant melanoma, confirmed by Fontana Masson and S-100 protein staining. A diagnosis of disseminated malignant melanoma was made and the patient was treated symptomatically. The patient died in 4 months.

Verma Kaushal

1999-01-01

 
 
 
 
361

Redox Metabolism and Malignancy  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Redox balance underlies cellular homeostasis. Cancer initiation and progression has been linked to the disruption of redox balance and oxidative stress. Recent findings exemplify the distinctive roles of intra- and extraceullar redox state in the etiology and maintenance of oxidative stress associated with malignancy and metastasis. Within these compartments, redox sensitive cysteines play a critical role in regulating cell signaling events that act to promote the malignant phenotype via the ...

Grek, Christina L.; Tew, Kenneth D.

2010-01-01

362

Malignancy Risk in Vasculitis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The vasculitides encompass a rare subset of autoimmune diseases. Reports of the concurrent association of malignancies with some forms of vasculitis raise the possibility that patients with certain types of vasculitis may be at increased risk of cancer. Conversely, some forms of vasculitis may be a manifestation of malignancy. We review cancer risk in patients with large vessel vasculitis (giant cell arteritis and Takayasu arteritis), polyarteritis nodosa, and the circulating antineutrophil c...

Kermani, Tanaz A.; Warrington, Kenneth J.; Amin, Shreyasee

2011-01-01

363

Sorafenib Tosylate in Treating Patients With Malignant Mesothelioma.  

Science.gov (United States)

Epithelial Mesothelioma; Recurrent Malignant Mesothelioma; Sarcomatous Mesothelioma; Stage IA Malignant Mesothelioma; Stage IB Malignant Mesothelioma; Stage II Malignant Mesothelioma; Stage III Malignant Mesothelioma; Stage IV Malignant Mesothelioma

2013-06-04

364

Malignant eccrine paramar  

International Nuclear Information System (INIS)

Benign eccrine poroma arises from the intraepidermal portion of the eccrine gland duct. Malignant transformation is rare and should be suspected when these lesions present with pain, bleeding or itching. We report a 44-year-old male patient who presented primarily with a lesion diagnostic of benign eccrine poroma of the right foot sole with no clear evidence of malignancy, which was incompletely excised, followed 5 months later by local recurrence, ulceration, occasional bleeding and right inguinal lymphadenopathy. Incomplete excision of the primary tumor as well as excision of a skin lesion on the right knee joint revealed malignant eccrine poroma with aggressive histology, lymphovascular and perineural invasion. Investigations revealed no evidence of distant metastasis. This tumor might be malignant at the first presentation, which was not confirmed histopathologically considering the short duration of only 5 months for malignant transformation. The patient received 3 cycles of Docetaxel Taxotere, Cisplatin combination chemotherapy with partial response. The management of metastatic malignant eccrine poroma is difficult. It has proven resistant to many chemotherapeutic agents and radiotherapy. (author)

2005-01-01

365

Clinicopathological features of untreated fibrous hamartoma of infancy.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

AIM--To study the clinicopathological features of fibrous hamartoma of infancy in Nigerian children. METHODS--Six children aged between 6 months and 10 years were studied. All specimens were stained with haemotoxylin and eosin and examined routinely. The children were followed up for between one and three years. RESULTS--In four of the children lesions were present at birth; in the other two they appeared by the age of 1 year. Some of the children had had the lesion for between three and 10 y...

1993-01-01

366

Pentazocine-induced leg ulcers and fibrous papules  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We herein describe a case of 55-year-old farmer, who presented with chronic non-healing ulcers over both shins of 4 years duration. Intravenous drug abuse was suspected due to inability to find any venous access and all peripheral veins being found thickened and fibrosed. There were multiple atrophic scars in linear distribution in all limbs as well as in both groins. In addition there were multiple discrete fibrous papules in linear distribution on both hands, which were more obvious on the ...

De Dipankar; Dogra Sunil; Kanwar Amrinder

2007-01-01

367

Development of fibrous monoliths from mullite, alumina, and zirconia powders  

Energy Technology Data Exchange (ETDEWEB)

Fibrous monoliths (FMs) based on mullite combined with Al{sub 2}O{sub 3} and Y{sub 2}O{sub 3}-stabilized ZrO{sub 2} have been produced. These FMs incorporate duplex cells in which compressive residual stresses were engineered into the surfaces of the cells. The residual stresses should increase average cell strength, which may allow them to achieve mechanical properties comparable to those of Si{sub 3}N{sub 4}/BN FMs. The expected residual stresses have been calculated, and data on sintering and thermal expansion have been gathered. Prototype FMs were produced and their microstructure examined.

Polzin, B. J.; Cruse, T. A.; Singh, D.; Picciolo, J. J.; Tsaliagos, R. N.; Phelan, P. J.; Goretta, K. C.

2000-06-29

368

Subcritical statistics in rupture of fibrous materials: Experiments and model  

CERN Document Server

We study experimentally the slow growth of a single crack in a fibrous material and observe stepwise growth dynamics. We model the material as a lattice where the crack is pinned by elastic traps and grows due to thermally activated stress fluctuations. In agreement with experimental data we find that the distribution of step sizes follows sub-critical point statistics with a power law (exponent 3/2) and a stress-dependent exponential cut-off diverging at the critical rupture threshold.

Santucci, S; Ciliberto, S; Santucci, Stephane; Vanel, Loic; Ciliberto, Sergio

2004-01-01

369

Benign fibrous histocytoma of femur: a case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Benign fibrous histocytoma (BFH) is a rare benign tumor, commonly occurs in soft tissues with very few cases in bone recorded. BFH of bone usually occurs in patients after the age of 20 years and often locates in the epiphysis or diaphysis of tubular bones, especially the femur and tibia. Herein we report a case of BFH of femur. The radiography and CT scan revealed a well-defined unilocular osteolytic lesion in the left proximal femur with marginal sclerosis. MRI showed that the lesion was is...

Chen, Wen; Gu, Tao

2012-01-01

370

Actinides sorption on chitin sorbents with fibrous structure  

International Nuclear Information System (INIS)

Sorption of U, Pu, Am, Cm on chitin sorbents of mycous origin with fibrous structure is investigated. Effect of solutions pH, acids (HNO3, HCl, H3PO4, HAc) nature and concentration is studied, sorption kinetics and exchange capacity of sorbents are estimated. Sorbents are high-effective with respect to U(6), Pu(4), Am(3) and Cm(3) in wide range of pH(3-8) and acid concentrations (104-102 mol/l), where Kd = 103-105 ml/g. Effect of inorganic acid nature on Kd values is unessential

1997-01-01

371

Development of flame resistant treatment for nomex fibrous structures  

Science.gov (United States)

Technology which renders aramid fibrous structures flame resistant through chemical modification was developed. The project scaled up flame resistant treatment from laboratory fabric swatches of a few inches to efficiently producing ten yards of commercial width (41 inches) aromatic polyamide. The radiation intensity problem of the processor was resolved. Further improvement of the processor cooling system was recommended for two reasons: (1) To advance current technology of flame proofing Nomex fabric to higher oxygen enriched atmospheres; and (2) To adapt the processor for direct applicability to low cost commercial fabrics.

Toy, M. S.

1978-01-01

372

Characterization of three fibrous insulations for potential HTGR application  

International Nuclear Information System (INIS)

Three fibrous insulation materials manufactured by Babcock and Wilcox were characterized for possible use as HTGR core thermal insulations. These materials (Unifelt 3000 board, Unifelt 2600 board, and Kaowool blanket) were characterized by spectrographic analysis, x-ray diffractometry, scanning electron microscopy, ignition studies and bulk density measurements, resilience tests, helium permeation tests, and compressive stress-strain tests. Of these properties, resilience is the most important for determining acceptability of material for HTGR use. The arbitrary resilience acceptability criterion is 90% or greater after 20 h at 8160C (15000F). Based on the resilience test, the Unifelt 3000 was acceptable, the Unifelt 2600 was marginal, and the Kaowool was unacceptable

1980-01-01

373

Aggressive malignant abdominal mesothelioma: Clinical report  

International Nuclear Information System (INIS)

A 32-year-old Filipino female, working as an x-ray technician, presented to the Emergency Room (ER) with acute abdominal pain for one day. The pain was mainly on the left side and left hypochondrium. She had recurring abdominal pain before but not significant to worry her. She also complained of abdominal distension, which she noticed one week ago. Abdominal examination revealed fullness in the left hypochondrium with marked tenderness but negative rebound. Abdominal ultrasound (US) showed a huge mass mainly in the left hypochondrium. The origin of the mass cannot be identified by US. A computerized tomography scan showed a mass in the left side of the abdomen crossing the midline with a necrotic centre. The hospital course of the patient runs smoothly, and she was discharged after 7-days and referred to an Oncology Center. Abdominal mesothelioma is a neoplasm arising from the mesothelial surface lining the abdominal cavity. It is less frequent than that of the pleura. It is a rapidly growing and fatal malignancy with a median survival of less than 1-year. The relation between pleural malignant mesothelioma and asbestos is well recognized since it was described in 19602 but implication of asbestos exposure in the etiology of the peritoneal type is less obvious. This patient history is giving no obvious exposure to asbestos but as she is working in the Radiology Department as an x-ray technician she is well exposed to x-ray, but the effect of radioactivity on induction of mesothelioma is still disputed.4 There are several reports linking malignant mesothelioma to radioactivity due to radiation therapy.The fibrous mesothelioma (sarcomatous), as in this case, which is difficult to diagnose microscopically, looks like a fibroma, unless helped by tissue culture. The treatment options of malignant mesothelioma include surgery, intraperitoneal chemotherapy and whole abdominal radiation or multimodality therapy, which were suggested that might prolong the survival in patients with peritoneal mesothelioma.5 Although peritoneal mesothelioma is rare, progress in its management has occurred, survival has been extended and selection factors by which patients may be allocated to aggressive management strategies have been defined

2004-01-01

374

Management of malignant pleural effusions.  

LENUS (Irish Health Repository)

Malignant pleural effusions are a common clinical problem in patients with primary thoracic malignancy and metastatic malignancy to the thorax. Symptoms can be debilitating and can impair tolerance of anticancer therapy. This article presents a comprehensive review of pharmaceutical and nonpharmaceutical approaches to the management of malignant pleural effusion, and a novel algorithm for management based on patients\\' performance status.

Uzbeck, Mateen H

2010-06-01

375

A new eudesmane sesquiterpene glucoside from Liriope muscari fibrous roots.  

Science.gov (United States)

The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus). From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-?-D-glucopyranoside) and three known glycosides [1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (liriopeoside A), 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside, and 1?,6?-dihydroxy-5,10-bis-epi-eudesm-4(15)-ene-6-O-? D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-?-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC(50 )value of 339.76 ?g/mL, while liriopeoside A (LC(50) = 82.84 ?g/mL) and 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (LC(50) = 153.39 ?g/mL) also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC(50) value of 182.56 ?g/mL. PMID:22031065

Zhang, Hai Ming; Wang, Gang Li; Bai, Chun Qi; Liu, Peng; Liu, Zi Mu; Liu, Qi Zhi; Wang, Yong Yan; Liu, Zhi Long; Du, Shu Shan; Deng, Zhi Wei

2011-01-01

376

A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots  

Directory of Open Access Journals (Sweden)

Full Text Available The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus. From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-?-D-glucopyranoside and three known glycosides [1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (liriopeoside A, 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside, and 1?,6?-dihydroxy-5,10-bis-epi-eudesm-4(15-ene-6-O-? D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-?-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC50 value of 339.76 ?g/mL, while liriopeoside A (LC50 = 82.84 ?g/mL and 1?,6?-dihydroxy-cis-eudesm-3-ene-6-O-?-D-glucopyranoside (LC50 = 153.39 ?g/mL also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC50 value of 182.56 ?g/mL.

Yong Yan Wang

2011-10-01

377

[Is it necessary to remove fibrous insulation material from buildings?].  

Science.gov (United States)

Because of potential negative health effects of exposure to airborne fibres, removal of fibrous insulating materials from buildings, particularly asbestos, has become a frequent, in many cases unjustified, undertaking. The results are presented of the determination of airborne mineral respirable and non-respirable fibres, fragments and total airborne dust in a public building before the substitution of the insulating material, shortly after, and about two months later. There were no differences (P greater than 0.05) between the mean concentrations of respirable fibres (diameter less than or equal to 3 microns, length greater than or equal to 5 microns, aspect ratio greater than or equal to 3:1) measured before (0.0038 and 0.0031 f/cm3, resp.) and about two months after (0.0038 and 0.0028 f/cm3, resp.) the substitution, suggesting that the substitution was unnecessary. However, the concentrations measured two and eight days after the substitution were significantly elevated (P less than 0.05; P less than 0.01, resp.), indicating that the unnecessary disturbance of the insulating material caused an increase of exposure levels of the employees. It is concluded that the removal or substitution of fibrous insulating materials, solely on the basis of their presence in the buildings, is unjustified. The decision should be based on elevated concentrations of airborne fibres objectively quantified. Unnecessary substitution brings about an increase, not a decrease, of the concentrations through a shorter or longer period of time. PMID:2092651

Cigula, M; Vali?, F

1990-12-01

378

Formation of fibrous materials from dense calcium caseinate dispersions.  

Science.gov (United States)

Application of shear and cross-linking enzyme transglutaminase (Tgase) induced fibrous hierarchical structures in dense (30% w/w) calcium caseinate (Ca-caseinate) dispersions. Using Tgase was essential for the anisotropic structure formation. The fibrous materials showed anisotropy on both micro- and macroscale as determined with scanning electron microscopy (SEM) and mechanical analyses, respectively. SEM revealed protein fibers with a diameter of approximately 100-200 nm; visually, we observed fibers of about 1 mm. Both shear and Tgase affected the reinforcement of the fibers to a large extent, whereas the mechanical properties in the direction perpendicular to the shear flow remained constant. Shearing Ca-caseinate without Tgase yielded a slightly anisotropic layered structure. Both cross-linking in the absence of shear and cross-linking during mixing resulted in gels without alignment. The formation of shear- and enzyme-induced anisotropic structures was explained by aligning of protein aggregates due to shear and concurrent solidification of the aligned protein aggregates. PMID:17326681

Manski, Julita M; van der Goot, Atze J; Boom, Remko M

2007-04-01

379

Malignant colorectal polyps  

Directory of Open Access Journals (Sweden)

Full Text Available Nowadays, the number of cases in which malignant colorectal polyps are removed is increasing due to colorectal cancer screening programmes. Cancerous polyps are classified into non-invasive high grade neoplasia (NHGN, when the cancer has not reached the muscularis mucosa, and malignant polyps, classed as T1, when they have invaded the submucosa. NHGN is considered cured with polypectomy, while the prognosis for malignant polyps depends on various morphological and histological factors. The prognostic factors include, sessile or pedunculated morphology of the polyp, whether partial or en bloc resection is carried out, the degree of differentiation of the carcinoma, vascular or lymphatic involvement, and whether the polypectomy resection margin is tumor free. A malignant polyp at T1 is considered cured with polypectomy if it is a pedunculated polyp (Ip of the Paris classification, it has been completely resected, it is not poorly differentiated, the resection edge is not affected by the tumor and there is no vascular or lymphatic involvement. The sessile malignant polyp (Is of the Paris classification at T1 is considered not cured with polypectomy. Only in some cases (e.g. older people with high surgical risk local excision (polypectomy or endoscopic submucosal dissection or conventional endoscopic mucosal resection is considered the definitive treatment.

Luis Bujanda, Angel Cosme, Ines Gil, Juan I Arenas-Mirave

2010-07-01

380

MALIGNANT SALIVARY GLAND TUMORS  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant salivary gland tumors make up 6% of all head and neck tumors. Several types of cancer can develop in these glands. Only malignant tumors of the salivary glands are discussed in this paper. The diagnosis and treatment of salivary gland malignancies remain complex, with challenging problems for maxillo-facial surgeon. Scientists have found few risk factors that make a person more likely to develop salivary gland cancer. Salivary gland cancer is uncommon, and there is no widely recommended screening schedule for this cancer. CT scanning or MRI is useful for determining the extent of large tumors, for evaluating extraglandular extension, for determining the actual depth of parotid tumors, and for discovering other tumors in one gland or in the controlateral gland. Fine-needle aspiration biopsy (FNAB is a valuable diagnostic adjunct in evaluation of head and neck masses but its role in evaluation of salivary gland tumors is controversial. There are also discussed some histologic findings about mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, carcinoma ex-pleomorphic adenoma, squamous cell carcinoma and adenocarcinoma developed in salivary glands. Carefully planned and executed surgical excision is the primary treatment for all malignant tumors of the salivary glands. The principles of surgery vary with the site of origin. The extent of surgery is based on the size of the tumor, local extension and neck metastases. Staging of malignant salivary gland tumors is important for predicting prognosis and for accurate comparison of treatment results.

Violeta Trandafir

2010-05-01

 
 
 
 
381

Primary malignant rhabdoid melanoma.  

Science.gov (United States)

Melanoma with rhabdoid features is an uncommon variant of malignant melanoma. Here, we describe a rare case of primary rhabdoid malignant melanoma. A 54-year-old man presented with a black tumor measuring 3×4 cm on the right forearm. Histologic sections showed a tumor mass with rhabdoid features composed entirely of polygonal neoplastic cells with eccentric nuclei, prominent nucleoli, and large hyaline cytoplasmic inclusions. The tumor cells were immunoreactive with HMB-45, S100, Fontana-Masson silver and vimentin, and negative for smooth muscle actin, CD68, CD34, CD99, synaptophysin, desmin, and PAS. The differential diagnosis for this tumor included malignant peripheral nerve sheath tumor, malignant peripheral neuroectodermal tumor and rhabdomyosarcoma. The patient was treated with a wide excision and a local skin graft. The excised tumor was entirely composed of rhabdoid tumor cells. No recurrence or metastasis was evident 4 months after removal. This article is relevant to rare cases of primary malignant melanomas showing rhabdoid tumor cells over the entire excised lesion. PMID:22148039

Chung, Bo Young; Ahn, In Su; Cho, Soo Ick; Kim, Hye One; Kim, Kwang Ho; Park, Chun Wook; Lee, Cheol Heon

2011-10-01

382

Fibrous monoliths: Economic ceramic matrix composites from powders[Final report]; FINAL  

International Nuclear Information System (INIS)

The project was to develop and perform pilot-scale production of fibrous monolith composites. The principal focus of the program was to develop damage-tolerant, wear-resistant tooling for petroleum drilling applications and generate a basic mechanical properties database on fibrous monolith composites

1999-01-01

383

Successful endoscopic removal of a giant upper esophageal inflammatory fibrous polyp  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Giant esophageal inflammatory fibrous polyp (especially > 17 cm in size) is seen rarely. Endoscopic removal has been reported rarely because the procedure is technically demanding and the hemostasis is difficult to ascertain. Here, we describe a case of a giant upper esophageal inflammatory fibrous polyp that was resected successfully by endoscopy.

Zhang, Jie; Hao, Jian-yu; Li, Simon Wing Heng; Zhang, Shu-tian

2009-01-01

384

Successful endoscopic removal of a giant upper esophageal inflammatory fibrous polyp  

Directory of Open Access Journals (Sweden)

Full Text Available Giant esophageal inflammatory fibrous polyp (especially > 17 cm in size is seen rarely. Endoscopic removal has been reported rarely because the procedure is technically demanding and the hemostasis is difficult to ascertain. Here, we describe a case of a giant upper esophageal inflammatory fibrous polyp that was resected successfully by endoscopy.

Jie Zhang, Jian-Yu Hao, Simon Wing Heng Li, Shu-Tian Zhang

2009-11-01

385

RECENT DEVELOPMENTS IN ANALYTICAL METHODS FOR FIBROUS AMPHIBOLE IN VERMICULITE ATTIC INSULATION  

Science.gov (United States)

The U.S. Environmental Protection Agency has developed a test method for the analysis of fibrous amphibole in vermiculite attic insulation. This method was developed to provide the Agency with monitoring tools to study the occurrence and potential for exposure to fibrous amphibo...

386

Fibrous dysplasia associated with intramuscular myxoma(mazabraud's syndrome) : a case report  

International Nuclear Information System (INIS)

Mazabraud's syndrome, the etiology of which is unknown, is a rare benign disease, characterized by the association of intramuscular myxoma and fibrous dysplasia of bone, usually polyostotic. We describe a case of Mazabraud's syndrome in which with two intramuscular myxomas of the forearm were associated with polyostotic fibrous dysplasia

1999-05-01

387

Fibrous dysplasia associated with intramuscular myxoma(mazabraud's syndrome) : a case report  

Energy Technology Data Exchange (ETDEWEB)

Mazabraud's syndrome, the etiology of which is unknown, is a rare benign disease, characterized by the association of intramuscular myxoma and fibrous dysplasia of bone, usually polyostotic. We describe a case of Mazabraud's syndrome in which with two intramuscular myxomas of the forearm were associated with polyostotic fibrous dysplasia.

Chun, Kyung Ah; Kim, Ki Tae; Kim, Young Joo; Maeng, Lee So; Lee, Eun Jung [The Catholic Univ. of Korea, College of Medicine, Seoul (Korea, Republic of)

1999-05-01

388

PET in uterine malignancies  

Directory of Open Access Journals (Sweden)

Full Text Available Positron Emission Tomography (PET or integrated PET/Computed Tomography (PET/CT with 18F-Fluoro-Deoxy-Glucose (18F-FDG is a functional imaging modality, useful in the characterization of undetermined morphological findings, and in the staging/re-staging of a large number of malignancies. Although its use in uterine malignancies has been poorly investigated, in recent years the employment of this technique has constantly increased. In this review, we evaluate the role of PET (/CT with 18FFDG in uterine malignancies (cervical and endometrial cancers as well as uterine sarcomas, underlying its advantages and discussing its limitations. Metabolic and anatomic information given by PET/CT with 18F-FDG could be useful in the evaluation of local and distant disease involvement at the staging, in the detection of disease recurrence, and in the evaluation of the response after chemotherapy and/or radio-therapy.

Valeria Pirro

2010-07-01

389

Fibrous scar in the infrapatellar fat pad after arthroscopy. MR imaging  

Energy Technology Data Exchange (ETDEWEB)

We describe the MR appearance of fibrous scars in the infrapatellar fat pad after arthroscopy. The subjects were 96 patients who underwent arthroscope-assisted anterior cruciate ligament (ACL) reconstruction and were examined by oblique sagittal MR imaging at different follow-up intervals. Two observers evaluated the characteristics of the fibrous scars in the infrapatellar fat pad. All fibrous scars with low signal intensity were accentuated at the portal and coursed horizontally through the infrapatellar fat pad. The fibrous scar within the fat pad occurred and peaked within 6 months after arthroscopy. It then subsided gradually and had disappeared by one year later in nearly half of the patients. Identifying MR imaging characteristics of fibrous scars in the fat pad after arthroscopy may be clinically helpful to differentiate these scars from other abnormalities that involve the infrapatellar fat pad. (author)

Tang, Guangyu; Niitsu, Mamoru; Ikeda, Kotaro; Itai, Yuji [Tsukuba Univ., Ibaraki (Japan). Inst. of Clinical Medicine; Endo, Hideho

2000-02-01

390

Microsurgery for malignant gliomas.  

Science.gov (United States)

Reflections directly involving the ongoing, intense research activities in biology, the neurosciences and in neurosurgery are discussed including the evolving diagnostic and treatment modalities of primary and secondary malignant gliomas of the central nervous system. The etiology of this enigmatic disease remains obscure, and a curative therapy is still not available. Nevertheless, as a result of changing paradigms in neuroanatomy, neuropathology, neurophysiology, neuroradiology and in neurosurgery, and taking into account the broader selection of adjuvant therapies available, well circumscribed malignant gliomas, which are in predilected compartments of the brain, can be efficiently resected. Good life quality and a respectable survival time are achieved in the majority of patients. PMID:15527081

Ya?argil, M Gazi; Kadri, Paulo A S; Yasargil, Dianne C H

2004-01-01

391

PET in uterine malignancies  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Positron Emission Tomography (PET) or integrated PET/Computed Tomography (PET/CT) with 18F-Fluoro-Deoxy-Glucose (18F-FDG) is a functional imaging modality, useful in the characterization of undetermined morphological findings, and in the staging/re-staging of a large number of malignancies. Although its use in uterine malignancies has been poorly investigated, in recent years the employment of this technique has constantly increased. In this review, we evaluate the role of PET (/CT) with 18FF...

2010-01-01

392

Malignant system diseases  

International Nuclear Information System (INIS)

Following a brief survey on the not entirely clear aetiology of the malignant system diseases, their epidemiology and histology, as well as the clinic and treatment fundamentals. The author deals with malignant lymphoma and the myeloproliferative diseases in two special sections. In the case of lymphoma he distinguishes between the treatment of Hodgkin lymphoma and non-Hodgkin lymphoma and gives a survey on the histology, various stages, performance of radiotherapy with therapy plan, as well as prognoses and results. The myeloproliferative diseases are treated according to their individual forms (acute, chronic, myeloic leukemia and chronic lymphatic leukemia, osteomyelosklerosis, polycythaemic vera, plasmocytoma and eosinophile granulom) and the corresponding form of radiotherapy. (MG)

1980-01-01

393

Malignant myoepithelioma of palate.  

Science.gov (United States)

Malignant myoepithelioma is a rare salivary gland neoplasm, which accounts for less than 2% of all the salivary gland carcinomas. Majority of cases have been reported in parotid, and only 8 cases of involvement of the hard palate have been reported in the literature so far. Hereby, a case of painless, ulcerated palatal mass of 2 years of duration reported. A diagnosis of malignant plasmacytoid myoepithelioma was made with the aid of immunohistochemical analysis, and wide surgical excision was considered keeping in mind the biological behavior of the tumor. PMID:23293504

Richa; Ray, Jay Gopal; Mohanty, Sweta Pattanayak; Vibha

2012-07-01

394

Pleural spill malign  

International Nuclear Information System (INIS)

The pleural spills are developed because of an alteration in the mechanisms that usually move between 5 and 10 liters of liquid through the space pleural every 24 hours and this is reabsorbed, only leaving 5 to 20 ml present. The causes more common of spill pleural they are: congestive heart failure, bacterial pneumonia, malign neoplasia and pulmonary clot. The causes more common of pleural spill malign in general are: cancer of the lung, cancer of the breast and lymphomas. In the man, cancer of the lung, lymphomas and gastrointestinal cancer. In the woman, cancer of the breast, gynecological cancer and lung cancer. The paper, includes their characteristics, treatments and medicines

2002-03-01

395

Microstructure and properties of nano-fibrous PCL-b-PLLA scaffolds for cartilage tissue engineering  

Directory of Open Access Journals (Sweden)

Full Text Available Nano-fibrous scaffolds which could potentially mimic the architecture of extracellular matrix (ECM have been considered a good candidate matrix for cell delivery in tissue engineering applications. In the present study, a semicrystalline diblock copolymer, poly(e-caprolactone-block-poly(L-lactide (PCL-b-PLLA, was synthesized and utilized to fabricate nano-fibrous scaffolds via a thermally induced phase separation process. Uniform nano-fibrous networks were created by quenching a PCL-b-PLLA/THF homogenous solution to -20ºC or below, followed by further gelation for 2 hours due to the presence of PLLA and PCL microcrystals. However, knot-like structures as well as continuously smooth pellicles appeared among the nano-fibrous network with increasing gelation temperature. DSC analysis indicated that the crystallization of PCL segments was interrupted by rigid PLLA segments, resulting in an amorphous phase at high gelation temperatures. Combining TIPS (thermally induced phase separation with salt-leaching methods, nano-fibrous architecture and interconnected pore structures (144±36 mm in diameter with a high porosity were created for in vitro culture of chondrocytes. Specific surface area and protein adsorption on the surface of the nano-fibrous scaffold were three times higher than on the surface of the solid-walled scaffold. Chondrocytes cultured on the nano-fibrous scaffold exhibited a spherical condrocyte-like phenotype and secreted more cartilage-like extracellular matrix (ECM than those cultured on the solid-walled scaffold. Moreover, the protein and DNA contents of cells cultured on the nano-fibrous scaffold were 1.2-1.4 times higher than those on the solid-walled scaffold. Higher expression levels of collagen II and aggrecan mRNA were induced on the nano-fibrous scaffold compared to on the solid-walled scaffold. These findings demonstrated that scaffolds with a nano-fibrous architecture could serve as superior scaffolds for cartilage tissue engineering.

L He

2009-10-01

396

An epidemiological and clinical analysis of craniomaxillofacial fibrous dysplasia in a Chinese population  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Craniomaxillofacial fibrous dysplasia (FD is a benign bone lesion characterized by facial disfigurement and functional impairment. The aim of this study was to characterize the epidemiological and clinical features of craniomaxillofacial FD by presenting data from a representative Chinese population during a 15-year period (1994–2009. Method The craniomaxillofacial disease registries of two Chinese tertiary referral hospitals (Shanghai Ninth People’s Hospital and Stomatological hospital of Jiangsu Province were searched and reviewed to collect relevant information for patients with craniomaxillofacial FD between Jan.1994 and Dec.2009. All included cases were further analyzed with regard to associated epidemiological and clinicopathological variables. Results A total number of 266 cases with definitive diagnosis were identified with 219 primary cases and 47 recurrent cases. There were 111 males and 155 females with a male to female ratio of 0.716:1. They were clinically categorized into three groups: monostotic (71.1%, polysotic (27.4% and Albright syndrome (1.5%. Maxilla alone or with adjacent bones was the most common affected site. The serum alkaline phosphatase (ALP in patients was much higher than that in healthy control, whereas comparable between primary patients and recurrent ones. Three patients (3/266, 1.1% with polysotic lesions underwent spontaneous malignant transformation into osteosarcoma. The majority of patients underwent conservative surgery, while the others received radical resection with or without reconstruction. Conclusions Craniomaxillofacial FD is a rare bony disorder with defined epidemiological and clinicopathological features in Chinese population. Further investigations are warranted to establish the optimized timing, treatment strategy and prognostic prediction for this clinical entity.

Cheng Jie

2012-10-01

397

Alumina composites for oxide/oxide fibrous monoliths  

International Nuclear Information System (INIS)

Most work on ceramic fibrous monoliths (FMs) has focused on the Si_3N_4/BN system. In an effort to develop oxidation-resistant FMs, several oxide systems have recently been examined. Zirconia-toughened alumina and alumina/mullite appear to be good candidates for the cell phase of FMs. These composites offer higher strength and toughness than pure alumina and good high-temperature stability. By combining these oxides, possibly with a weaker high-temperature oxide as the cell-boundary phase, it should be possible to product a strong, resilient FM that exhibits graceful failure. Several material combinations have been examined. Results on FM fabrication and microstructural development are presented

2000-01-23

398

Performance of superplasticised fibrous concrete on RCPT test under thermoshock  

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Full Text Available This experimental investigation is about the chloride ion penetration of concrete under effect of thermo shock on superplasticised fibrous concrete at 200 degree Celsius. As reported in previous studies concretes made with purely Ordinary Portland Cement (OPC showed evidence of a steady decline in residual strength when subjected to thermoshock under elevated temperatures. In the present study tests were conducted to minimize the reduction of residual strength under compression, minimize the chloride ion penetration of OPC concrete by using chemical admixtures like superplasticiser and with different individual fibers. This paper exposes the details of the test programme, results and also compares against the same with earlier reports. From this test results, it was found that the residual properties of concrete were not affected and data available here will be helpful in assessing the residual strength of concrete after thermoshock.

G. Elangovan

2010-01-01

399

Polyelectrolyte-complex nanostructured fibrous scaffolds for tissue engineering  

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In the current work, polyelectrolyte complex (PEC) fibrous scaffolds for tissue engineering have been synthesized and a mechanism of their formation has been investigated. The scaffolds are synthesized using polygalacturonic acid and chitosan using the freeze drying methodology. Highly interconnected pores of sizes in the range of 5-20 {mu}m are observed in the scaffolds. The thickness of the fibers was found to be in the range of 1-2 {mu}m. Individual fibers have a nanogranular structure as observed using AFM imaging. In these scaffolds, PEC nanoparticles assemble together at the interface of ice crystals during freeze drying process. Further investigation shows that the freezing temperature and concentration have a remarkable effect on structure of scaffolds. Biocompatibility studies show that scaffold containing chitosan, polygalacturonic acid and hydroxyapatite promotes cell adhesion and proliferation. On the other hand, cells on scaffolds fabricated without hydroxyapatite nanoparticles showed poor adhesion.

Verma, Devendra [Department of Civil Engineering, North Dakota State University, Fargo, ND 58105 (United States); Katti, Kalpana S., E-mail: Kalpana.Katti@ndsu.edu [Department of Civil Engineering, North Dakota State University, Fargo, ND 58105 (United States); Katti, Dinesh R. [Department of Civil Engineering, North Dakota State University, Fargo, ND 58105 (United States)

2009-08-31

400

Aerosol filtration by fibrous filter mats. Part III. Geometric relations  

International Nuclear Information System (INIS)

The aerosol filtration characteristics of ten randomly formed fibrous filter mats, of widely varying compositions and physical properties, were studied as a function of both the superficial linear flow velocity and the aerosol diameter size. The flow regime ranged from 7.2 to 141 cm/sec with ten discrete velocities. Four diameter sizes of dioctylphthalate (DOP) aerosol were used to challenge the filter mats over this velocity range, namely, 0.26, 0.28, 0.30, and 0.32 microns. Mathematical equations, derived from the original Dorman aerosol equations, provided insight on the interrelationships between aerosol size, flow velocity, and the diffusion, interception, and inertia mechanisms of aerosol filtration. (U.S.)

1975-03-01

 
 
 
 
401

Nonlinear analysis of laminated fibrous composites. Ph.D. Thesis  

Science.gov (United States)

A computerized analysis of the nonlinear behavior of fibrous composite laminates including axial loading, thermal loading, temperature dependent properties, and edge effects is presented. Ramberg-Osgood approximations are used to represent lamina stress-strain behavior and percent retention curves are employed to model the variation of properties with temperature. Balanced, symmetric laminates comprised of either boron/epoxy, graphite/epoxy, or borsic-aluminum are analyzed using a quasi-three-dimensional finite element analysis. Results are presented for the interlaminar stress distributions in cross-ply, angle-ply, and more complex laminates. Nonlinear stress-strain curves for a variety of composite laminates in tension and compression are obtained and compared to other existing theories and experimental results.

Renieri, G. D.; Herakovich, C. T.

1976-01-01

402

Fabrication and characterization of oxide fibrous monoliths produced by coextrusion.  

Energy Technology Data Exchange (ETDEWEB)

Unidirectional fibrous monoliths (FMs) based on dense, strong ZrSiO{sub 4} cells that were surrounded by a porous, weaker ZrSiO{sub 4} cell-boundary phase were fabricated. A duplex filament was coextruded, sectioned, bundled, and the resulting bundle was extruded to form a new filament. This filament was cut and packed into plate and bar dies to produce FM test specimens. Four-point flexural tests were conducted on the cell material, cell-boundary material, and FMs. After testing, fracture surfaces and cross sections were examined by scanning electron microscopy. The FMs exhibited graceful failure in flexural testing, and the fracture surfaces exhibited clear evidence of crack deflection and delamination.

Polzin, B. J.

1999-05-19

403

Solitary fibrous tumor of the liver: a case report  

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Full Text Available Abstract Hepatic solitary fibrous tumor (SFT is a rare tumor originating from the mesenchyme. Here we report a new case of SFT in the liver and review the clinical presentation, radiological and operative findings, diagnosis, treatment, and outcome. The patient was a 59-year-old man who presented with progressive fatigue for 3 months and an abdominal mass for 3 days. On laboratory tests, no abnormality was detected except that abdominal ultrasonography revealed a 9.0 × 6.2 cm hypoechogenic mass in the left lobe of the liver. A computed tomographic scan confirmed a hypodense lesion in the left lobe of the liver. The patient underwent left hepatectomy. SFT was diagnosed on the basis of histopathological findings. The patient was free from all symptoms and had no signs of local recurrence after 24 months' follow up.

Ying Li-Xiong

2011-03-01

404

Pentazocine-induced leg ulcers and fibrous papules  

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Full Text Available We herein describe a case of 55-year-old farmer, who presented with chronic non-healing ulcers over both shins of 4 years duration. Intravenous drug abuse was suspected due to inability to find any venous access and all peripheral veins being found thickened and fibrosed. There were multiple atrophic scars in linear distribution in all limbs as well as in both groins. In addition there were multiple discrete fibrous papules in linear distribution on both hands, which were more obvious on the left side. The patient denied abusing intravenous drugs. However, his relatives confirmed that he abused pentazocine for almost one year before his chronic pain in abdomen was treated by appendicectomy. With subsequent counseling, it was found that he continued to abuse pentazocine at times even after surgery leading to the non-healing of ulcers.

De Dipankar

2007-01-01

405

Pentazocine-induced leg ulcers and fibrous papules.  

Science.gov (United States)

We herein describe a case of 55-year-old farmer, who presented with chronic non-healing ulcers over both shins of 4 years duration. Intravenous drug abuse was suspected due to inability to find any venous access and all peripheral veins being found thickened and fibrosed. There were multiple atrophic scars in linear distribution in all limbs as well as in both groins. In addition there were multiple discrete fibrous papules in linear distribution on both hands, which were more obvious on the left side. The patient denied abusing intravenous drugs. However, his relatives confirmed that he abused pentazocine for almost one year before his chronic pain in abdomen was treated by appendicectomy. With subsequent counseling, it was found that he continued to abuse pentazocine at times even after surgery leading to the non-healing of ulcers. PMID:17456919

De, Dipankar; Dogra, Sunil; Kanwar, Amrinder J

2007-01-01

406

Case report 490: Monostotic fibrous dysplasia of the pubis  

International Nuclear Information System (INIS)

An expansile lesion of the superior pubic ramus in a 32 year old man was discovered incidentally when roentgenograms were obtained to assess the possibility of fracture following an automobile accident. A technetium scan showed increased uptake in the lesion and computed tomography showed expansion of the superior pubic ramus and extension of the lesion from the pubic symphysis to the acetabulum. A needle aspirate of the lesion consisted of blood and giant cells. Based on the appearance of the lesion and the needle aspirate a preliminary diagnosis of giant cell tumor or aneurysmal bone cyst was made. When examined at the time of operation, the lesion was found to be firm and gritty. It was removed and the remaining bone surfaces curetted. Histological examination showed a pattern most consistent with fibrous dysplasia. The pubic ramus healed uneventfully. (orig.)

1988-01-01

407

Hyperostotic esthesioneuroblastoma: rare variant and fibrous dysplasia mimicker.  

Science.gov (United States)

A 65-year-old male presented with a 3-year history of orbital symptoms. An imaging-based diagnosis of fibrous dysplasia involving the skull base was made at another institution. CT showed a diffuse sinonasal mass and ground-glass appearance of the bones of the anterior skull base with bony defects and mucocele formation. MRI demonstrated an accompanying intracranial and orbital rind of soft tissue mass along the hyperostotic bones. FDG-PET showed corresponding intense hypermetabolism. Small cysts were observed at the tumor-brain interface. Biopsy revealed esthesioneuroblastoma with bone infiltration that is compatible with the hyperostotic variant of esthesioneuroblastoma. There are a few cases of hyperostotic esthesioneuroblastoma reported in the literature. PMID:24497807

Ahmed, Manzoor; Knott, Phillip Daniel

2014-01-01

408

Malignant pleural mesothelioma  

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Malignant mesothelioma is one of the rare tumors of pleura. One such case in a 57-year-old male, who presented with hemorrhagic pleural effusion and had no history of asbestos exposure, is reported here. The rarity, unusual presentation, and implications are discussed.

2009-01-01

409

Malignant pleural mesothelioma  

Directory of Open Access Journals (Sweden)

Full Text Available Malignant mesothelioma is one of the rare tumors of pleura. One such case in a 57-year-old male, who presented with hemorrhagic pleural effusion and had no history of asbestos exposure, is reported here. The rarity, unusual presentation, and implications are discussed.

Rao Sukhesh

2009-01-01

410

[Malignant transperitoneal bladder rupture].  

Science.gov (United States)

The authors report a case of malignant intraperitoneal bladder rupture due to a stage PT1 grade II bladder tumour. The clinical features, mechanism of rupture, treatment and subsequent follow-up are discussed in the light of a review of the literature. PMID:12765069

Ziadé, Jean; Delepaul, Bruno; Ducq, Pierre

2003-04-01

411

Malignant pleural diseases.  

Science.gov (United States)

The incidence of malignant pleural effusions has been increasing over the last few decades (mainly due to the absolute increase in several types of cancers, especially those of lung and breast origin) and they account for up to 50% of the exudates in many clinical series. Although pleural malignancies are thought to present most frequently with a pleural effusion, several autopsy series, including the current one, found a pleural effusion present in little more than half of the cases of malignant pleural involvement (55% in this series). Thus, many pleural malignancies without effusion might pass unnoticed in clinical practice, especially in metastatic disease. Primary malignancies of the pleura (mesotheliomas) are associated with asbestos exposure in about two-thirds of cases, and they frequently present with chest pain, sometimes associated with a pleural effusion. Benign pleural plaques can coexist with malignant mesothelioma, and this association should be suspected when long-standing plaques change in shape or size over the years, and especially if chest pain develops in a previously asymptomatic patient. Metastatic pleural involvement is much more frequent than mesotheliomas, and its most frequent mechanism is the vascular spreading of tumour cells from distant organs to the lungs, and on to the visceral and parietal pleura. The visceral pleura was involved in up to 87% of the current metastatic cases, whereas the parietal zone in only 47% of the autopsy series. The diagnostic work-up lies in cytology, whose average yield is approximately 50%, and a biopsy technique (either by blind needle biopsy or thoracoscopy) is recommended when the effusion persists, for > 2 weeks, and the first cytology has been negative. Thoracoscopy has the additional advantage of allowing pleurodesis with talc poudrage if clear tumour lesions are found in the pleura. In cases of malignant effusion which are not sensitive to chemotherapy, pleurodesis is the treatment of choice for palliation of symptoms, and talc is the most effective agent. It can be used either in suspension ("slurry") or in dry aerosolized form ("talc poudrage"), but it seems that this last technique achieves the best effects. However, it requires thoracoscopy for a proper application, and this is its main drawback when that technique is not readily available. PMID:10786419

Rodriguez-Panadero, F

2000-02-01

412

Computed Tomography Characteristics of Non-Syndromic Craniofacial Fibrous Dysplasia  

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Full Text Available Background: Fibrous dysplasia is a benign fibro-osseous tumor of bones commonlyinvolving the craniofacial region. Computed tomography (CT imagingstudy of the disease is useful for evaluation and treatment planning.However, few studies have evaluated such large patient series.Methods: A total of 46 patients with complete medical records and CT images wasincluded in this study. All of these patients were non-syndromic, had fibrousdysplasia involving only the craniofacial region, and had no skin pigmentationor other evidence of endocrine problems. Data analyses were performedon the clinical manifestations, time of onset, signs and symptoms, involvementof cranial and facial bones, and CT appearance of the tumors in thispatient group.Results: Painless swelling was the chief clinical problem in 78% of patients, followesby dental malocclusion in 22%. Onset of the disease was reported to haveoccurred before 6 years of age in 34%, between 6 and 10 years in 27%, andolder than 10 years in 39% of patients. Extreme timings such as onset atinfancy or older than 20 years of age were also noted. The average numberof bones involved was 3.2 bones per patient. Involvement of more than onecraniofacial bone occurred in 70% of patients. The maxilla, orbital, andfrontal bones were most commonly involved. CT images appeared scleroticor homogenous in 34%, mixed white and dark or heterogenous in 55%, andcystic in 11%. A correlation between the age of onset of the disease and thenumber of bones involved was not observed.Conclusions: Findings of this study demonstrate that craniofacial fibrous dysplasia displaysa wide spectrum of clinical behaviors. CT imaging generally revealedextensive involvement of the tumor in the craniofacial region.

Lun-Jou Lo

2002-01-01

413

Genetics Home Reference: Malignant hyperthermia  

Science.gov (United States)

... to malignant hyperthermia? Variations of the CACNA1S and RYR1 genes increase the risk of developing malignant hyperthermia. ... by mutations in different genes. Mutations in the RYR1 gene are responsible for a form of the ...

414

Drugs Approved for Malignant Mesothelioma  

Science.gov (United States)

... by the Food and Drug Administration (FDA) for malignant mesothelioma. The list includes generic names and brand ... Information summaries. There may be drugs used in malignant mesothelioma that are not listed here.

415

JAMA Patient Page: Malignant Hyperthermia  

Science.gov (United States)

... of the American Medical Association JAMA PATIENT PAGE Malignant Hyperthermia M alignant hyperthermia ( MH ) is severe, potentially ... energy consumption after exposure to certain anesthetic drugs. Malignant hyperthermia occurs in persons who have a genetic ( ...

416

A study on heat transfer characteristics of spherical and fibrous alumina nanofluids  

Energy Technology Data Exchange (ETDEWEB)

Highlights: Black-Right-Pointing-Pointer Spherical and fibrous alumina nanoparticles were prepared by pulsed wire evaporation and hydrolysis methods. Black-Right-Pointing-Pointer Fibrous alumina nanofluid exhibited higher thermal conductivity enhancement than spherical one due to entangled structure of nanofibers with high aspect-ratio. Black-Right-Pointing-Pointer Decreasing rate of viscosity with temperature for fibrous alumina nanofluid was much larger than that for spherical one. - Abstract: Ethylene glycol based nanofluids containing spherical/fibrous alumina nanoparticles were synthesized by pulsed wire evaporation and hydrolysis methods. The crystallographic and morphological properties of the prepared nanoparticles were analyzed by X-ray diffraction, nitrogen gas adsorption and transmission electron microscopy. The average diameter of spherical alumina nanoparticles was about 80 nm and the alumina nanofibers exhibited a high aspect ratio (length/width). The viscosity and thermal conductivity of the spherical/fibrous alumina nanofluids were experimentally measured in the temperature range from 25 to 80 Degree-Sign C. For the fibrous alumina nanofluid, the increase of temperature raised thermal conductivity but lowered viscosity. On the other hand, for the spherical alumina nanofluid, both thermal conductivity and viscosity were decreased with increasing temperature. In particular, the fibrous alumina nanofluid exhibited a higher enhancement of thermal conductivity than the spherical one due to the well-connected structure between entangled nanofibers with high aspect ratio.

Kim, Chang Kyu [Nuclear Materials Research Division, Korea Atomic Energy Research Institute, Daeduk-daero 989-111, Dukjin-dong, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Quantum Energy Chemical Engineering, University of Science and Technology, 176 Gajung-dong, 217 Gajungro, Yuseong-gu, Daejeon 305-350 (Korea, Republic of); Lee, Gyoung-Ja [Nuclear Materials Research Division, Korea Atomic Energy Research Institute, Daeduk-daero 989-111, Dukjin-dong, Yuseong-gu, Daejeon 305-353 (Korea, Republic of); Rhee, Chang Kyu, E-mail: ckrhee@kaeri.re.kr [Nuclear Materials Research Division, Korea Atomic Energy Research Institute, Daeduk-daero 989-111, Dukjin-dong, Yuseong-gu, Daejeon 305-353 (Korea, Republic of)

2012-08-20

417

A study on heat transfer characteristics of spherical and fibrous alumina nanofluids  

International Nuclear Information System (INIS)

Highlights: ? Spherical and fibrous alumina nanoparticles were prepared by pulsed wire evaporation and hydrolysis methods. ? Fibrous alumina nanofluid exhibited higher thermal conductivity enhancement than spherical one due to entangled structure of nanofibers with high aspect-ratio. ? Decreasing rate of viscosity with temperature for fibrous alumina nanofluid was much larger than that for spherical one. - Abstract: Ethylene glycol based nanofluids containing spherical/fibrous alumina nanoparticles were synthesized by pulsed wire evaporation and hydrolysis methods. The crystallographic and morphological properties of the prepared nanoparticles were analyzed by X-ray diffraction, nitrogen gas adsorption and transmission electron microscopy. The average diameter of spherical alumina nanoparticles was about 80 nm and the alumina nanofibers exhibited a high aspect ratio (length/width). The viscosity and thermal conductivity of the spherical/fibrous alumina nanofluids were experimentally measured in the temperature range from 25 to 80 °C. For the fibrous alumina nanofluid, the increase of temperature raised thermal conductivity but lowered viscosity. On the other hand, for the spherical alumina nanofluid, both thermal conductivity and viscosity were decreased with increasing temperature. In particular, the fibrous alumina nanofluid exhibited a higher enhancement of thermal conductivity than the spherical one due to the well-connected structure between entangled nanofibers with high aspect ratio.

2012-08-20

418

Malignant lymphoma involving the penis following malignant pleural mesothelioma.  

Science.gov (United States)

A 74-year-old man who had been diagnosed with malignant mesothelioma developed malignant lymphoma of B-cell origin involving the penis. He had a history of occupational exposure to asbestos as a construction worker. The association of malignant mesothelioma with lymphoma is rare, and the possibility of asbestos exposure as a common etiology is discussed. The intense stimulation of B lymphocytes and decreased T lymphocyte activity in asbestos-exposed populations may result in development of B-cell malignancies. Though the relationship between asbestos exposure and malignant mesothelioma is firmly established, the relationship between asbestos exposure and lymphoma remains to be investigated. PMID:9372333

Takabe, K; Tsukada, Y; Shimizu, T; Takagiwa, J; Hirayama, M; Nakayama, M; Miura, H; Akabane, H; Takayama, S; Aida, S; Kimura, Y

1997-10-01

419

Malignant Melanoma of the Foot  

Science.gov (United States)

... Melanoma of the Foot Text Size Print Bookmark Malignant Melanoma of the Foot What is Malignant Melanoma? Melanoma is a cancer that begins in ... that produce pigmentation (coloration). It is also called malignant melanoma because it spreads to other areas of ...

420

Malignant Mesothelioma of Tunica Vaginalis  

Directory of Open Access Journals (Sweden)

Full Text Available Mesothelioma is often diagnosed as a malignant scrotal mass without pain or inflammatory signs. It is a very rare tumor with quite uncommon sites of involvement. This form of malignancy generally involves pleura, with a differential diagnosis of undifferentiated carcinoma expectable in this area related to epididymis and rete testis. Keywords: Malignant mesothelioma, Scrotal mass

M Mokhtari

2004-02-01

 
 
 
 
421

A large infiltrating fibrous hamartoma of infancy in the abdominal wall with rare associated tuberous sclerosis  

International Nuclear Information System (INIS)

Tuberous sclerosis is a complex autosomal-dominant neurocutaneous syndrome characterized by hamartomatous malformations of fibrous and connective tissues in various organs. Although various histologic types of soft-tissue masses can occur with tuberous sclerosis, we present a unique case of fibrous hamartoma of infancy presenting as large infiltrating cutaneous and subcutaneous masses in the abdominal wall in a 4-year-old boy with tuberous sclerosis. Although the co-occurrence of tuberous sclerosis and fibrous hamartoma of infancy is very rare, it should be considered in the differential diagnosis of subcutaneous soft-tissue masses found in children with tuberous sclerosis. (orig.)

2009-07-01

422

Comparison of MRA source image and IVUS for evaluating fibrous cap of carotid plaque  

International Nuclear Information System (INIS)

The purpose is evaluating the usefulness of three-dimensional (3D) time of flight (TOF) MR angiography (MRA) source image for investigating fibrous cap of carotid plaque. The percentage of fibrous cap defect of 17 carotid stenotic lesions was calculated on both MRA source images and intravascular ultrasound (IVUS) images. Five lesions were correlated, but 9 had slight gap (10-20%) and 3 had moderate gap (30-40%). There was significant correlation (P<;0.01, r=0.721) by the Pearson's correlation coefficient. MRA source image can evaluate fibrous cap of carotid plaque. (author)

2007-11-01

423

Stromal, Fibrous, and Fatty Gastrointestinal Tumors Associated With A PDGFRA Gene Mutation  

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We report the case of a woman with 3 different types of gastrointestinal tumors—stromal, fibrous, and fatty—and a germline defect of the PDGFRA gene (V561D). The patient, now 52 years old, presented in 1977 at age 22 years with a gastric tumor and a duodenal lipoma. Subsequently, she developed KIT-negative, CD34-positive obstructing small intestinal fibrous tumors that required three laparotomies and intestinal resections. Most recently (in 2002), more than 100 of the fibrous tumors were ...

Carney, J. Aidan; Stratakis, Constantine A.

2008-01-01

424

A large infiltrating fibrous hamartoma of infancy in the abdominal wall with rare associated tuberous sclerosis  

Energy Technology Data Exchange (ETDEWEB)

Tuberous sclerosis is a complex autosomal-dominant neurocutaneous syndrome characterized by hamartomatous malformations of fibrous and connective tissues in various organs. Although various histologic types of soft-tissue masses can occur with tuberous sclerosis, we present a unique case of fibrous hamartoma of infancy presenting as large infiltrating cutaneous and subcutaneous masses in the abdominal wall in a 4-year-old boy with tuberous sclerosis. Although the co-occurrence of tuberous sclerosis and fibrous hamartoma of infancy is very rare, it should be considered in the differential diagnosis of subcutaneous soft-tissue masses found in children with tuberous sclerosis. (orig.)

Han, Hye-Jeong; Lim, Gye-Yeon [The Catholic University of Korea, Department of Radiology, St. Mary' s Hospital, Seoul (Korea); You, Chang-Young [The Catholic University of Korea, Department of Pathology, St. Mary' s Hospital, Seoul (Korea)

2009-07-15

425

Case report 557: Solitary intramuscular myxoma in a patient with polyostotic fibrous dysplacia  

Energy Technology Data Exchange (ETDEWEB)

We report a case of solitary intramuscular myxoma in a patient with polyostotic fibrous dysplasia and pigmented macules. MR played an important role in the patient's pre-operative evaluation. It has been demonstrated in a review of the literature that a definite relationship exists between myxoma of soft tissues and fibrous dysplasia of the skeleton. Multiple myxomas in a patient with fibrous dysplasia are common and a relationship also exists between myxoma of the soft tissues and the McCune-Albright syndrome. (orig./GDG).

Glass-Royal, M.C.; Nelson, M.C.; Albert, F.; Lack, E.E.; Bogumill, G.P. (Georgetown Univ., Washington, DC (USA). Medical Center)

1989-08-01

426

Case report 557: Solitary intramuscular myxoma in a patient with polyostotic fibrous dysplacia  

International Nuclear Information System (INIS)

We report a case of solitary intramuscular myxoma in a patient with polyostotic fibrous dysplasia and pigmented macules. MR played an important role in the patient's pre-operative evaluation. It has been demonstrated in a review of the literature that a definite relationship exists between myxoma of soft tissues and fibrous dysplasia of the skeleton. Multiple myxomas in a patient with fibrous dysplasia are common and a relationship also exists between myxoma of the soft tissues and the McCune-Albright syndrome. (orig./GDG)

1989-01-01

427

Rapid Biodiesel Fuel Production Using Novel Fibrous Catalyst Synthesized by Radiation-Induced Graft Polymerization  

Directory of Open Access Journals (Sweden)

Full Text Available An efficient fibrous catalyst for the biodiesel fuel production has been synthesized by radiation-induced graft polymerization of 4-chloromethylstyrene onto a nonwoven polyethylene (NWPE fabric followed by amination with trimethylamine (TMA and further treatment with NaOH. The degree of grafting of NWPE fabric and TMA group density of fibrous catalyst could easily and reproducibly be controlled within a range of up to 340% and 3.6 mmol-TMA/g-catalyst, respectively. In the transesterification of triglycerides and ethanol using the synthesized fibrous catalyst, the conversion ratio of triglycerides reached 95% after 4 h reaction at 50°C.

Nor Hasimah Mohamed

2011-05-01

428

Polyostotic fibrous dysplasia associated with intramuscular myxomas: Mazabraud's syndrome  

International Nuclear Information System (INIS)

Mazabraud's syndrome, though uncommon, is reported increasingly frequently. It represents an entity readily recognisable radiologically on MR imaging. Awareness of the syndrome, particularly when the myxoma is solitary, can prevent misdiagnosis of intramuscular myxomas (especially when large) as malignant mesenchymal tumors containing myxoid tissue. We review the 34 cases previously reported in the literature and include a recent case from our center. (orig.)

1998-05-01

429

Hematologic malignancies and thrombosis.  

Science.gov (United States)

Patients with hematologic malignancies have an increased risk of venous thromboembolism (VTE), particularly at diagnosis and during the treatment with chemotherapy, asparaginase or immunomodulatory drugs (IMiDs). A disease-dependent hypercoagulable condition associated with other risk factors like drugs, central venous catheter (CVC), immobility and infections are responsible for this high VTE rate. Thrombotic complications have a significant impact on morbidity and in some cases also on mortality of patients with onco-hematologic diseases, therefore thromboprophylaxis to prevent VTE in this setting is needed. However, thrombocytopenia and hemorrhagic complications pone many difficulties in the management of an anticoagulant or antiaggregant treatment in these patients. Recommendations from current guidelines are limited to multiple myeloma patients treated with thalidomide or lenalidomide associated with dexamethasone or chemotherapy, but hematological clinical departments should implement a policy for prevention and treatment of thromboembolic complications in hematologic malignancies. PMID:22197450

Elice, F; Rodeghiero, F

2012-03-01

430

Malignant insulinoma in childhood.  

Science.gov (United States)

Pancreatic tumors constitute a rare surgical problem in infancy and childhood. Insulinomas are rare in all age groups with an estimated incidence of one per 250,000 person-years and even rarer in childhood. We report a 10 year-old girl with malignant insulinoma. The presenting symptom was hypoglycemic attacks. Laboratory investigation demonstrated that the hypoglycemia was due to hyperinsulinism. MRI of the abdomen revealed a mass at the tail of the pancreas. Distal pancreatectomy with splenectomy was performed. Histological examination showed malignant insulinoma with peripancreatic lymph node metastases. One month later abdominal MRI revealed the existence of multiple small metastatic foci in the liver, which were confirmed by In111 octreoscan. Treatment with octreotide was started and the disease is stable after 12 months of therapy. PMID:16789643

Karachaliou, Feneli; Vlachopapadopoulou, Elpis; Kaldrymidis, Philipos; Simatos, George; Zacharea, Maria; Spanidou-Karvouni, Erini; Michalacos, Stefanos; Voros, Dionyssios

2006-05-01