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Sample records for magnetoencephalography multipolar modeling

  1. MEG (Magnetoencephalography) multipolar modeling of distributed sources using RAP-MUSIC (Recursively Applied and Projected Multiple Signal Characterization)

    Energy Technology Data Exchange (ETDEWEB)

    Mosher, J. C. (John C.); Baillet, S. (Sylvain); Jerbi, K. (Karim); Leahy, R. M. (Richard M.)

    2001-01-01

    We describe the use of truncated multipolar expansions for producing dynamic images of cortical neural activation from measurements of the magnetoencephalogram. We use a signal-subspace method to find the locations of a set of multipolar sources, each of which represents a region of activity in the cerebral cortex. Our method builds up an estimate of the sources in a recursive manner, i.e. we first search for point current dipoles, then magnetic dipoles, and finally first order multipoles. The dynamic behavior of these sources is then computed using a linear fit to the spatiotemporal data. The final step in the procedure is to map each of the multipolar sources into an equivalent distributed source on the cortical surface. The method is illustrated through an application to epileptic interictal MEG data.

  2. On MEG forward modelling using multipolar expansions

    International Nuclear Information System (INIS)

    Magnetoencephalography (MEG) is a non-invasive functional imaging modality based on the measurement of the external magnetic field produced by neural current sources within the brain. The reconstruction of the underlying sources is a severely ill-posed inverse problem typically tackled using either low-dimensional parametric source models, such as an equivalent current dipole (ECD), or high-dimensional minimum-norm imaging techniques. The inability of the ECD to properly represent non-focal sources and the over-smoothed solutions obtained by minimum-norm methods underline the need for an alternative approach. Multipole expansion methods have the advantages of the parametric approach while at the same time adequately describing sources with significant spatial extent and arbitrary activation patterns. In this paper we first present a comparative review of spherical harmonic and Cartesian multipole expansion methods that can be used in MEG. The equations are given for the general case of arbitrary conductors and realistic sensor configurations and also for the special cases of spherically symmetric conductors and radially oriented sensors. We then report the results of computer simulations used to investigate the ability of a first-order multipole model (dipole and quadrupole) to represent spatially extended sources, which are simulated by 2D and 3D clusters of elemental dipoles. The overall field of a cluster is analysed using singular value decomposition and compared to the unit fields of a multipole, centred in the middle of the cluster, using subspace correlation metrics. Our results demonstrate the superior utility of the multipolar source model over ECD models in providing source representations of extended regions of activity. (author)

  3. Magnetoencephalography

    International Nuclear Information System (INIS)

    Although magnetoencephalography (MEG) may not be familiar to many pediatric radiologists, it is an increasingly available neuroimaging technique both for evaluating normal and abnormal intracranial neural activity and for functional mapping. By providing spatial, temporal, and time-frequency spectral information, MEG affords patients with epilepsy, intracranial neoplasia, and vascular malformations an opportunity for a sensitive and accurate non-invasive preoperative evaluation. This technique can optimize selection of surgical candidates as well as increase confidence in preoperative counseling and prognosis. Research applications that appear promising for near-future clinical translation include the evaluation of children with autism spectrum disorder, traumatic brain injury, and schizophrenia. (orig.)

  4. Magnetoencephalography

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, Erin Simon [Children' s Hospital of Philadelphia, Lurie Family Foundations MEG Imaging Center, Department of Radiology, Philadelphia, PA (United States); Children' s Hospital of Philadelphia, Department of Radiology, Philadelphia, PA (United States); Edgar, J.C.; Gaetz, William C.; Roberts, Timothy P.L. [Children' s Hospital of Philadelphia, Lurie Family Foundations MEG Imaging Center, Department of Radiology, Philadelphia, PA (United States)

    2010-01-15

    Although magnetoencephalography (MEG) may not be familiar to many pediatric radiologists, it is an increasingly available neuroimaging technique both for evaluating normal and abnormal intracranial neural activity and for functional mapping. By providing spatial, temporal, and time-frequency spectral information, MEG affords patients with epilepsy, intracranial neoplasia, and vascular malformations an opportunity for a sensitive and accurate non-invasive preoperative evaluation. This technique can optimize selection of surgical candidates as well as increase confidence in preoperative counseling and prognosis. Research applications that appear promising for near-future clinical translation include the evaluation of children with autism spectrum disorder, traumatic brain injury, and schizophrenia. (orig.)

  5. A wind-shell interaction model for multipolar planetary nebulae

    CERN Document Server

    Steffen, W; Esquivel, A; Garcia-Segura, G; Garcia-Diaz, Ma T; Lopez, J A; Magnor, M

    2013-01-01

    We explore the formation of multipolar structures in planetary and pre-planetary nebulae from the interaction of a fast post-AGB wind with a highly inhomogeneous and filamentary shell structure assumed to form during the final phase of the high density wind. The simulations were performed with a new hydrodynamics code integrated in the interactive framework of the astrophysical modeling package SHAPE. In contrast to conventional astrophysical hydrodynamics software, the new code does not require any programming intervention by the user for setting up or controlling the code. Visualization and analysis of the simulation data has been done in SHAPE without external software. The key conclusion from the simulations is that secondary lobes in planetary nebulae, such as Hubble 5 and K3-17, can be formed through the interaction of a fast low-density wind with a complex high density environment, such as a filamentary circumstellar shell. The more complicated alternative explanation of intermittent collimated outflow...

  6. Analytic and numerical models of the 3D multipolar magnetospheres of pre-main sequence stars

    CERN Document Server

    Gregory, S G

    2011-01-01

    Traditionally models of accretion of gas on to T Tauri stars have assumed a dipole stellar magnetosphere, partly for simplicity, but also due to the lack of information about their true magnetic field topologies. Before and since the first magnetic maps of an accreting T Tauri star were published in 2007 a new generation of magnetospheric accretion models have been developed that incorporate multipole magnetic fields. Three-dimensional models of the large-scale stellar magnetosphere with an observed degree of complexity have been produced via numerical field extrapolation from observationally derived T Tauri magnetic maps. Likewise, analytic and magnetohydrodynamic models with multipolar stellar magnetic fields have been produced. In this conference review article we compare and contrast the numerical field extrapolation and analytic approaches, and argue that the large-scale magnetospheres of some (but not all) accreting T Tauri stars can be well described by tilted dipole plus tilted octupole field componen...

  7. Magnetoencephalography recording and analysis

    Directory of Open Access Journals (Sweden)

    Jayabal Velmurugan

    2014-01-01

    Full Text Available Magnetoencephalography (MEG non-invasively measures the magnetic field generated due to the excitatory postsynaptic electrical activity of the apical dendritic pyramidal cells. Such a tiny magnetic field is measured with the help of the biomagnetometer sensors coupled with the Super Conducting Quantum Interference Device (SQUID inside the magnetically shielded room (MSR. The subjects are usually screened for the presence of ferromagnetic materials, and then the head position indicator coils, electroencephalography (EEG electrodes (if measured simultaneously, and fiducials are digitized using a 3D digitizer, which aids in movement correction and also in transferring the MEG data from the head coordinates to the device and voxel coordinates, thereby enabling more accurate co-registration and localization. MEG data pre-processing involves filtering the data for environmental and subject interferences, artefact identification, and rejection. Magnetic resonance Imaging (MRI is processed for correction and identifying fiducials. After choosing and computing for the appropriate head models (spherical or realistic; boundary/finite element model, the interictal/ictal epileptiform discharges are selected and modeled by an appropriate source modeling technique (clinically and commonly used - single equivalent current dipole - ECD model. The equivalent current dipole (ECD source localization of the modeled interictal epileptiform discharge (IED is considered physiologically valid or acceptable based on waveform morphology, isofield pattern, and dipole parameters (localization, dipole moment, confidence volume, goodness of fit. Thus, MEG source localization can aid clinicians in sublobar localization, lateralization, and grid placement, by evoking the irritative/seizure onset zone. It also accurately localizes the eloquent cortex-like visual, language areas. MEG also aids in diagnosing and delineating multiple novel findings in other neuropsychiatric disorders, including Alzheimer?s disease, Parkinsonism, Traumatic brain injury, autistic disorders, and so oon.

  8. A Textural–Contextual Model for Unsupervised Segmentation of Multipolarization Synthetic Aperture Radar Images

    OpenAIRE

    Akbari, Vahid; Doulgeris, Anthony Paul; Gabriele, Moser; Eltoft, Torbjørn; Sebastiano, B. Serpico; Anfinsen, Stian Normann

    2013-01-01

    This paper proposes a novel unsupervised, non-Gaussian, and contextual segmentation method that combines an advanced statistical distribution with spatial contextual informa-tion for multilook polarimetric synthetic aperture radar (PolSAR)data. This extends on previous studies that have shown the added value of both non-Gaussian modeling and contextual smoothing individually or for intensity channels only. The method is based on a Markov random field (MRF) model that integrates a K-Wishart d...

  9. Detecting forest structure and biomass with C-band multipolarization radar - Physical model and field tests

    Science.gov (United States)

    Westman, Walter E.; Paris, Jack F.

    1987-01-01

    The ability of C-band radar (4.75 GHz) to discriminate features of forest structure, including biomass, is tested using a truck-mounted scatterometer for field tests on a 1.5-3.0 m pygmy forest of cypress (Cupressus pygmaea) and pine (Pinus contorta ssp, Bolanderi) near Mendocino, CA. In all, 31 structural variables of the forest are quantified at seven sites. Also measured was the backscatter from a life-sized physical model of the pygmy forest, composed of nine wooden trees with 'leafy branches' of sponge-wrapped dowels. This model enabled independent testing of the effects of stem, branch, and leafy branch biomass, branch angle, and moisture content on radar backscatter. Field results suggested that surface area of leaves played a greater role in leaf scattering properties than leaf biomass per se. Tree leaf area index was strongly correlated with vertically polarized power backscatter (r = 0.94; P less than 0.01). Field results suggested that the scattering role of leaf water is enhanced as leaf surface area per unit leaf mass increases; i.e., as the moist scattering surfaces become more dispersed. Fog condensate caused a measurable rise in forest backscatter, both from surface and internal rises in water content. Tree branch mass per unit area was highly correlated with cross-polarized backscatter in the field (r = 0.93; P less than 0.01), a result also seen in the physical model.

  10. A DETAILED SPATIOKINEMATIC MODEL OF THE CONICAL OUTFLOW OF THE MULTIPOLAR PLANETARY NEBULA NGC 7026

    Energy Technology Data Exchange (ETDEWEB)

    Clark, D. M.; Lopez, J. A.; Steffen, W.; Richer, M. G., E-mail: dmclark@astro.unam.mx [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Campus Ensenada, Ensenada, Baja California, CA 22860 (United States)

    2013-03-15

    We present extensive, long-slit, high-resolution coverage of the complex planetary nebula (PN) NGC 7026. We acquired 10 spectra using the Manchester Echelle Spectrometer at San Pedro Martir Observatory in Baja California, Mexico, and each shows exquisite detail, revealing the intricate structure of this object. Incorporating these spectra into the three-dimensional visualization and kinematic program SHAPE and using Hubble Space Telescope images of NGC 7026, we have produced a detailed structural and kinematic model of this PN. NGC 7026 exhibits remarkable symmetry consisting of three lobe pairs and four sets of knots, all symmetrical about the nucleus and displaying a conical outflow. Comparing the three-dimensional structure of this nebula to recent XMM-Newton X-ray observations, we investigate the extended X-ray emission in relation to the nebular structure. We find that the X-ray emission, while confined to the closed, northern lobes of this PN, shows an abrupt termination in the middle of the southeast lobe, which our long slit data show to be open. This is where the shocked fast wind seems to be escaping the interior of the nebula and the X-ray emission rapidly cools in this region.

  11. A Detailed Spatiokinematic Model of the Conical Outflow of the Multipolar Planetary Nebula, NGC 7026

    CERN Document Server

    Clark, D M; Steffen, W; Richer, M G

    2012-01-01

    We present an extensive, long-slit, high-resolution coverage of the complex planetary nebula (PN), NGC 7026. We acquired ten spectra using the Manchester Echelle Spectrometer at San Pedro Martir Observatory in Baja California, Mexico, and each shows exquisite detail, revealing the intricate structure of this object. Incorporating these spectra into the 3-dimensional visualization and kinematic program, SHAPE, and using HST images of NGC 7026, we have produced a detailed structural and kinematic model of this PN. NGC 7026 exhibits remarkable symmetry consisting of three lobe-pairs and four sets of knots, all symmetrical about the nucleus and displaying a conical outflow. Comparing the 3-D structure of this nebula to recent, XMM-Newton X-ray observations, we investigate the extended X-ray emission in relation to the nebular structure. We find that the X-ray emission, while confined to the closed, northern lobes of this PN, shows an abrupt termination in the middle of the SE lobe, which our long slit data shows ...

  12. Dynamic filtering of static dipoles in magnetoencephalography

    OpenAIRE

    Sorrentino, Alberto; Johansen, Adam M.; Aston, John A.D.; Nichols, Thomas E.; Kendall, Wilfrid S.

    2012-01-01

    We consider the problem of estimating neural activity from measurements of the magnetic fields recorded by magnetoencephalography. We exploit the temporal structure of the problem and model the neural current as a collection of evolving current dipoles, which appear and disappear, but whose locations are constant throughout their lifetime. This fully reflects the physiological interpretation of the model. In order to conduct inference under this proposed model, it was necess...

  13. The role of multipolar magnetic fields in pulsar magnetospheres

    CERN Document Server

    Asséo, E; Asseo, Estelle; Khechinashvili, David

    2002-01-01

    We explore the role of complex multipolar magnetic fields in determining physical processes near the surface of rotation powered pulsars. We model the actual magnetic field as the sum of global dipolar and star-centered multipolar fields. In configurations involving axially symmetric and uniform multipolar fields, 'neutral points' and 'neutral lines' exist close to the stellar surface. Also, the curvature radii of magnetic field lines near the stellar surface can never be smaller than the stellar radius, even for very high order multipoles. Consequently, such configurations are unable to provide an efficient pair creation process above pulsar polar caps, necessary for plasma mechanisms of generation of pulsar radiation. In configurations involving axially symmetric and non-uniform multipoles, the periphery of the pulsar polar cap becomes fragmented into symmetrically distributed narrow sub-regions where curvature radii of complex magnetic field lines are less than the radius of the star. The pair production p...

  14. Direct reconstruction algorithm of current dipoles for vector magnetoencephalography and electroencephalography

    Science.gov (United States)

    Nara, Takaaki; Oohama, Junji; Hashimoto, Masaru; Takeda, Tsunehiro; Ando, Shigeru

    2007-07-01

    This paper presents a novel algorithm to reconstruct parameters of a sufficient number of current dipoles that describe data (equivalent current dipoles, ECDs, hereafter) from radial/vector magnetoencephalography (MEG) with and without electroencephalography (EEG). We assume a three-compartment head model and arbitrary surfaces on which the MEG sensors and EEG electrodes are placed. Via the multipole expansion of the magnetic field, we obtain algebraic equations relating the dipole parameters to the vector MEG/EEG data. By solving them directly, without providing initial parameter guesses and computing forward solutions iteratively, the dipole positions and moments projected onto the xy-plane (equatorial plane) are reconstructed from a single time shot of the data. In addition, when the head layers and the sensor surfaces are spherically symmetric, we show that the required data reduce to radial MEG only. This clarifies the advantage of vector MEG/EEG measurements and algorithms for a generally-shaped head and sensor surfaces. In the numerical simulations, the centroids of the patch sources are well localized using vector/radial MEG measured on the upper hemisphere. By assuming the model order to be larger than the actual dipole number, the resultant spurious dipole is shown to have a much smaller strength magnetic moment (about 0.05 times smaller when the SNR = 16 dB), so that the number of ECDs is reasonably estimated. We consider that our direct method with greatly reduced computational cost can also be used to provide a good initial guess for conventional dipolar/multipolar fitting algorithms.

  15. Direct reconstruction algorithm of current dipoles for vector magnetoencephalography and electroencephalography

    International Nuclear Information System (INIS)

    This paper presents a novel algorithm to reconstruct parameters of a sufficient number of current dipoles that describe data (equivalent current dipoles, ECDs, hereafter) from radial/vector magnetoencephalography (MEG) with and without electroencephalography (EEG). We assume a three-compartment head model and arbitrary surfaces on which the MEG sensors and EEG electrodes are placed. Via the multipole expansion of the magnetic field, we obtain algebraic equations relating the dipole parameters to the vector MEG/EEG data. By solving them directly, without providing initial parameter guesses and computing forward solutions iteratively, the dipole positions and moments projected onto the xy-plane (equatorial plane) are reconstructed from a single time shot of the data. In addition, when the head layers and the sensor surfaces are spherically symmetric, we show that the required data reduce to radial MEG only. This clarifies the advantage of vector MEG/EEG measurements and algorithms for a generally-shaped head and sensor surfaces. In the numerical simulations, the centroids of the patch sources are well localized using vector/radial MEG measured on the upper hemisphere. By assuming the model order to be larger than the actual dipole number, the resultant spurious dipole is shown to have a much smaller strength magnetic moment (about 0.05 times smaller when the SNR = 16 dB), so that the number of ECDs is reasonably estimated. We consider that our direct method with greatly reduced computational cost can also be used to provide a good initial guess for conventional dipolar/multipolar fitting algorithms

  16. Direct reconstruction algorithm of current dipoles for vector magnetoencephalography and electroencephalography.

    Science.gov (United States)

    Nara, Takaaki; Oohama, Junji; Hashimoto, Masaru; Takeda, Tsunehiro; Ando, Shigeru

    2007-07-01

    This paper presents a novel algorithm to reconstruct parameters of a sufficient number of current dipoles that describe data (equivalent current dipoles, ECDs, hereafter) from radial/vector magnetoencephalography (MEG) with and without electroencephalography (EEG). We assume a three-compartment head model and arbitrary surfaces on which the MEG sensors and EEG electrodes are placed. Via the multipole expansion of the magnetic field, we obtain algebraic equations relating the dipole parameters to the vector MEG/EEG data. By solving them directly, without providing initial parameter guesses and computing forward solutions iteratively, the dipole positions and moments projected onto the xy-plane (equatorial plane) are reconstructed from a single time shot of the data. In addition, when the head layers and the sensor surfaces are spherically symmetric, we show that the required data reduce to radial MEG only. This clarifies the advantage of vector MEG/EEG measurements and algorithms for a generally-shaped head and sensor surfaces. In the numerical simulations, the centroids of the patch sources are well localized using vector/radial MEG measured on the upper hemisphere. By assuming the model order to be larger than the actual dipole number, the resultant spurious dipole is shown to have a much smaller strength magnetic moment (about 0.05 times smaller when the SNR = 16 dB), so that the number of ECDs is reasonably estimated. We consider that our direct method with greatly reduced computational cost can also be used to provide a good initial guess for conventional dipolar/multipolar fitting algorithms. PMID:17664582

  17. Strategies for Business Schools in a Multi-Polar World

    Science.gov (United States)

    Dameron, Stephanie; Durand, Thomas

    2013-01-01

    Purpose: The purpose of this paper is to examine the contours of the emerging business education and institutions in a multi-polar world and to identify the causes of the strategic convergence of management education, to explore the limitations of the dominant models of management education and to propose a range of strategic alternatives for…

  18. Decoding object representation using magnetoencephalography

    Directory of Open Access Journals (Sweden)

    Gustavo Sudre

    2010-03-01

    Full Text Available Several studies have used magnetoencephalography to investigate how the human brain processes language and recognizes objects. This work follows the footsteps of the encouraging results obtained by this group using fMRI to predict brain activity associated with the meaning of nouns. Here, we leverage the superior temporal resolution of MEG data to analyze the spatiotemporal activation following the presentation of concrete nouns, and then decode the different nouns presented to the subject during the recording session. More specifically, ten subjects were presented with 20 different questions about properties of 60 different objects. These questions probed properties such as size, material, and usage of each of the 60 objects (e.g. is it made of metal? Is it alive?. Each object was represented by its picture and name (text, displayed simultaneously on the screen. Subjects answered yes or no to the question at hand by pressing the right or the left response pad, respectively. The subjectʼs response also controlled when the current stimuli for a given object disappeared from the screen, giving the subject more control over the experiment and also making the task more engaging. In a separate experiment, the subjects were asked to think about properties of the 60 objects when they appeared in the screen, being as consistent as possible for each repetition of the same experiment. The MEG data were spatially filtered using Maxfilter [1], and then processed using MNE software [2]. Different machine learning techniques were implemented in MATLAB [3] for decoding, and preliminary results show accuracies as high as 91% (mean over subjects: 79% for classifying between two different words that the classifier has never seen before [4]. These results show that MEG data can be reliably used to decode concrete nouns presented to a subject, and the analysis of the features used for decoding may provide valuable insights to the inner-workings of the brain related to semantic representation.

  19. Second Language Research Using Magnetoencephalography: A Review

    Science.gov (United States)

    Schmidt, Gwen L.; Roberts, Timothy P. L.

    2009-01-01

    In this review we show how magnetoencephalography (MEG) is a constructive tool for language research and review MEG findings in second language (L2) research. MEG is the magnetic analog of electroencephalography (EEG), and its primary advantage over other cross-sectional (e.g. magnetic resonance imaging, or positron emission tomography) functional…

  20. SQUID-based multichannel system for Magnetoencephalography

    OpenAIRE

    Rombetto, S; Granata, C.; Vettoliere, A; Trebeschi, A; Rossi, R.; Russo, M.

    2013-01-01

    Here we present a multichannel system based on superconducting quantum interference devices (SQUIDs) for magnetoencephalography (MEG) measurements, developed and installed at Istituto di Cibernetica (ICIB) in Naples. This MEG system, consists of 163 full integrated SQUID magnetometers, 154 channels and 9 references, and has been designed to meet specifications concerning noise, dynamic range, slew rate and linearity through optimized design. The control electronics is locate...

  1. An Optical-Infrared Study of the Young Multipolar Planetary Nebula NGC 6644

    CERN Document Server

    Hsia, Chih Hao; Zhang, Yong; Koning, Nico; Volk, Kevin

    2010-01-01

    High-resolution HST imaging of the compact planetary nebula NGC 6644 has revealed two pairs of bipolar lobes and a central ring lying close to the plane of the sky. From mid-infrared imaging obtained with the Gemini Telescope, we have found a dust torus which is oriented nearly perpendicular to one pair of the lobes. We suggest that NGC 6644 is a multipolar nebula and have constructed a 3-D model which allows the visualization of the object from different lines of sight. These results suggest that NGC 6644 may have similar intrinsic structures as other multipolar nebulae and the phenomenon of multipolar nebulosity may be more common than previously believed.

  2. Excitation of single multipolar modes with engineered cylindrically symmetric fields

    CERN Document Server

    Zambrana-Puyalto, Xavier; Molina-Terriza, Gabriel

    2012-01-01

    We present a new method to address multipolar resonances and to control the scattered field of a spherical scatterer. This method is based on the engineering of the multipolar content of the incident beam. We propose experimentally feasible techniques to generate light beams which contain only a few multipolar modes. The techniques uses incident beams with a well defined component of the angular momentum and appropriate focusing with aplanatic lenses. The control of the multipolar content of light beams allow for the excitation of single Mie resonances and unprecedented control of the scattered field from spherical particles.

  3. Organizing for Spaces and Dynamics of Multipolar Learning in Multinational Corporations

    DEFF Research Database (Denmark)

    Hull Kristensen, Peer; Lotz, Maja

    Limited research has been conducted on how MNCs organize conditions and spaces for recursive learning to facilitate the practice of innovation across dispersed units as well as how organizational members at all levels may become involved in innovations through the engagement in ongoing multipolar...... formalized, yet autonomous and oriented toward a long-term continuous perspective in contrast to traditional hierarchical models....

  4. SQUID-based multichannel system for Magnetoencephalography

    CERN Document Server

    Rombetto, S; Vettoliere, A; Trebeschi, A; Rossi, R; Russo, M

    2013-01-01

    Here we present a multichannel system based on superconducting quantum interference devices (SQUIDs) for magnetoencephalography (MEG) measurements, developed and installed at Istituto di Cibernetica (ICIB) in Naples. This MEG system, consists of 163 full integrated SQUID magnetometers, 154 channels and 9 references, and has been designed to meet specifications concerning noise, dynamic range, slew rate and linearity through optimized design. The control electronics is located at room temperature and all the operations are performed inside a Magnetically Shielded Room (MSR). The system exhibits a magnetic white noise level of approximatively 5 fT/Hz1=2. This MEG system will be employed for both clinical and routine use. PACS numbers: 74.81.Fa, 85.25.Hv, 07.20.Mc, 85.25.Dq, 87.19.le, 87.85.Ng

  5. Magnetoencephalography from signals to dynamic cortical networks

    CERN Document Server

    Aine, Cheryl

    2014-01-01

    "Magnetoencephalography (MEG) provides a time-accurate view into human brain function. The concerted action of neurons generates minute magnetic fields that can be detected---totally noninvasively---by sensitive multichannel magnetometers. The obtained millisecond accuracycomplements information obtained by other modern brain-imaging tools. Accurate timing is quintessential in normal brain function, often distorted in brain disorders. The noninvasiveness and time-sensitivityof MEG are great assets to developmental studies, as well. This multiauthored book covers an ambitiously wide range of MEG research from introductory to advanced level, from sensors to signals, and from focal sources to the dynamics of cortical networks. Written by active practioners of this multidisciplinary field, the book contains tutorials for newcomers and chapters of new challenging methods and emerging technologies to advanced MEG users. The reader will obtain a firm grasp of the possibilities of MEG in the study of audition, vision...

  6. Optical near fields of multipolar particle plasmons

    International Nuclear Information System (INIS)

    Nanoscale noble metal particles are well known for their ability to sustain resonant electron plasma oscillations, so-called particle plasmons. This phenomenon gives rise to spectrally selective light absorption and to an enhancement of the local electric field. Due to these properties, metal nanoparticles are of high current interest for applications and fundamental research in fields as surface enhanced Raman scattering or nanoscale waveguides. Most investigations and applications focus on the dipolar resonances of such particles. However, the particular near-field profiles and far-field scattering patterns of higher order excitations are of interest as well and might be advantageous for specific applications. In this presentation, we report on experimental and theoretical studies of multipolar optical excitations in prolate metal nanoparticles. The results of optical far-field extinction spectroscopy and optical near-field measurements on such particles can be qualitatively understood in a physical picture of standing plasmon-waves. The specific properties of the optical near-fields of the multipolar excitations compared to dipolar excitations are emphasized. (author)

  7. Organizing for Spaces and Dynamics of Multipolar Learning in Multinational Corporations

    DEFF Research Database (Denmark)

    Hull Kristensen, Peer; Lotz, Maja

    2015-01-01

    Limited research has been conducted on how MNCs organize conditions and spaces for recursive learning to facilitate the practice of innovation across dispersed units as well as how organizational members at all levels may become involved in innovations through the engagement in ongoing multipolar learning dynamics. Based on longitudinal case studies in two MNCs this paper contributes with insights into how spaces and dynamics of multipolar learning are organized and governed across dispersed MNC units at the micro level of everyday work practices. The paper shows that it is possible to organize spaces and dynamics that can organize recursiveness and continuity in multipolar learning by way of experimentation with new coordination components and governance architectures. Against the previous literature, however, it becomes evident that these are not the outcome of spontaneous interactions in a tacit community of practices that operate on an ad hoc basis parallel to the formal organization. The spaces and dynamics must become a body in their own right, with a set of recursive steps or routines that produce distinct types of results. The system of multipolar learning itself must become formalized, yet autonomous and oriented toward a long-term continuous perspective in contrast to traditional hierarchical models.

  8. Monte Carlo analysis of localization errors in magnetoencephalography

    Energy Technology Data Exchange (ETDEWEB)

    Medvick, P.A.; Lewis, P.S.; Aine, C.; Flynn, E.R.

    1989-01-01

    In magnetoencephalography (MEG), the magnetic fields created by electrical activity in the brain are measured on the surface of the skull. To determine the location of the activity, the measured field is fit to an assumed source generator model, such as a current dipole, by minimizing chi-square. For current dipoles and other nonlinear source models, the fit is performed by an iterative least squares procedure such as the Levenberg-Marquardt algorithm. Once the fit has been computed, analysis of the resulting value of chi-square can determine whether the assumed source model is adequate to account for the measurements. If the source model is adequate, then the effect of measurement error on the fitted model parameters must be analyzed. Although these kinds of simulation studies can provide a rough idea of the effect that measurement error can be expected to have on source localization, they cannot provide detailed enough information to determine the effects that the errors in a particular measurement situation will produce. In this work, we introduce and describe the use of Monte Carlo-based techniques to analyze model fitting errors for real data. Given the details of the measurement setup and a statistical description of the measurement errors, these techniques determine the effects the errors have on the fitted model parameters. The effects can then be summarized in various ways such as parameter variances/covariances or multidimensional confidence regions. 8 refs., 3 figs.

  9. SQUID sensor array configurations for magnetoencephalography applications

    International Nuclear Information System (INIS)

    Electrophysiological activity in the human brain generates a small magnetic field from the spatial superposition of individual neuronal source currents. At a distance of about 15 mm from the scalp, the observed field is of the order of 10-13 to 10-12 T peak-to-peak. This measurement process is termed magnetoencephalography (MEG). In order to minimize instrumental noise, the MEG is usually detected using superconducting flux transformers, coupled to SQUID (superconducting quantum interference device) sensors. Since MEG signals are also measured in the presence of significant environmental magnetic noise, flux transformers must be designed to strongly attenuate environmental noise, maintain low instrumental noise and maximize signals from the brain. Furthermore, the flux transformers must adequately sample spatial field variations if the brain activity is to be imaged. The flux transformer optimization for maximum brain signal-to-noise ratio (SNR) requires analysis of the spatial and temporal properties of brain activity, the environmental noise and how these signals are coupled to the flux transformer. Flux transformers that maximize SNR can detect the smallest brain signals and have the best ability to spatially separate dipolar sources. An optimal flux transformer design is a synthetic higher-order gradiometer based on relatively short-baseline first-order radial gradiometer primary sensors. (author)

  10. Magnetoencephalography of epilepsy with a microfabricated atomic magnetrode.

    Science.gov (United States)

    Alem, Orang; Benison, Alex M; Barth, Daniel S; Kitching, John; Knappe, Svenja

    2014-10-22

    Magnetoencephalography has long held the promise of providing a noninvasive tool for localizing epileptic seizures in humans because of its high spatial resolution compared with the scalp EEG. Yet, this promise has been elusive, not because of a lack of sensitivity or spatial resolution but because the large size and immobility of present cryogenic (superconducting) technology prevent long-term telemetry required to capture these very infrequent epileptiform events. To circumvent this limitation, we used Micro-Electro-Mechanical Systems technology to construct a noncryogenic (room temperature) microfabricated atomic magnetometer ("magnetrode") based on laser spectroscopy of rubidium vapor and similar in size and flexibility to scalp EEG electrodes. We tested the magnetrode by measuring the magnetic signature of epileptiform discharges in a rat model of epilepsy. We were able to measure neuronal currents of single epileptic discharges and more subtle spontaneous brain activity with a high signal-to-noise ratio approaching that of present superconducting sensors. These measurements are a promising step toward the goal of high-resolution noninvasive telemetry of epileptic events in humans with seizure disorders. PMID:25339745

  11. THICK DISKS WITH NEWTONIAN MULTIPOLAR MOMENTS / DISCOS GRUESOS CON MOMENTOS MULTIPOLARES NEWTONIANOS

    Scientific Electronic Library Online (English)

    Framsol, López-Suspes; Guillermo A., González.

    2013-09-01

    Full Text Available Se presenta una nueva familia de discos gruesos newtonianos estables a partir del método de desplazamiento, corte, llenado y reflexión construidos en (González & Letelier, 2004; Vogt & Letelier, 2005). Soluciones de la ecuación de Laplace en coordenadas cilíndricas son consideradas, éstas representa [...] rán el campo gravitacional de objetos con momentos multipolares externos solamente. Se definen y calculan las cantidades físicas en el plano del disco, tales como, la frecuencia epicíclica, kapa, la frecuencia vertical, ny, y la velocidad circular, ípsilonc de las partículas. Además, se determina la densidad superficial de masa, sigma, la densidad del disco grueso, rho, y el criterio de estabilidad de los discos gruesos a través del momentum angular o el criterio de Rayleigh (Rayleigh, 1917; Landau, 1987). Finalmente, se representan las propiedades físicas para algunos parámetros considerando sólo hasta el término cuadrupolar en la expansión multipolar del potencial gravitacional. Abstract in english We present a new family of stable thick discs from known displace, cut, fill and reflect method (González & Letelier, 2004; Vogt & Letelier, 2005) is presented. Solutions of the Laplace equation in cylindrical coordinates are considered, these one represent the gravitational field of objects with on [...] ly external multipole moments. The physical quantities in the plane of the disk, are defined and calculated such as, the epicyclic frequency, kappa, the vertical frequency, nu, and the circular velocity, upsilonc of particles. The surface density, sigma, density of thick disk, rho, and stability of thick disks through of specific angular momentum or Rayleigh criterion (Rayleigh, 1917), and (Landau, 1987) were calculated. Finally, the physical properties are shown for only some parameters considering only until quadrupolar term in the expasion gravitational potential multipolar

  12. Multipolar instability of the bathtub vortex

    Science.gov (United States)

    Fabre, David; Guaus, Anaïs

    2004-11-01

    We consider the stability of a hollow core vortex, i.e. a vortex possessing a free surface separating a gaseous core and a liquid swirling rapidly in a potential way. The most familiar example is the so-called bathtub vortex which forms when a fluid drains out of a container. The study is divided in two parts. At first, the vortex is considered as a strictly axisymmetric cylindrical column. This allows to consider perturbations under the form of eigenmodes. A dispersion relation is derived, which allows to compute the frequency as function of the axial and azimuthal wavenumbers and of an inverse Weber number W characterizing the relative influence of the surface tension. In most cases, the flow is characterised by the presence of purely neutral waves (Kelvin waves). However, the flow is found to become unstable as soon as the effect of surface tension is sufficiently high. In the second part of the study, the vortex is considered as weakly deformed under the influence of a multipolar strain field with order of symmetry n. The study reveals that for moderate values of the surface tension, instabilities arise due to the coupling between Kelvin waves and the strain field. The instability growth is calculated as a function of the inverse Weber number, the strain order n and the characteristics of the Kelvin waves. The case of elliptic (n=2), tripolar (n=3) and quadripolar (n=4) strain fields are particularly considered. Finally, a comparison of these predictions with various availible experiments will be discussed.

  13. Magnetoencephalography with a two-color pump probe atomic magnetometer.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Cort N.

    2010-07-01

    The authors have detected magnetic fields from the human brain with a compact, fiber-coupled rubidium spin-exchange-relaxation-free magnetometer. Optical pumping is performed on the D1 transition and Faraday rotation is measured on the D2 transition. The beams share an optical axis, with dichroic optics preparing beam polarizations appropriately. A sensitivity of <5 fT/{radical}Hz is achieved. Evoked responses resulting from median nerve and auditory stimulation were recorded with the atomic magnetometer. Recordings were validated by comparison with those taken by a commercial magnetoencephalography system. The design is amenable to arraying sensors around the head, providing a framework for noncryogenic, whole-head magnetoencephalography.

  14. A global optimization approach to multi-polarity sentiment analysis.

    Science.gov (United States)

    Li, Xinmiao; Li, Jing; Wu, Yukeng

    2015-01-01

    Following the rapid development of social media, sentiment analysis has become an important social media mining technique. The performance of automatic sentiment analysis primarily depends on feature selection and sentiment classification. While information gain (IG) and support vector machines (SVM) are two important techniques, few studies have optimized both approaches in sentiment analysis. The effectiveness of applying a global optimization approach to sentiment analysis remains unclear. We propose a global optimization-based sentiment analysis (PSOGO-Senti) approach to improve sentiment analysis with IG for feature selection and SVM as the learning engine. The PSOGO-Senti approach utilizes a particle swarm optimization algorithm to obtain a global optimal combination of feature dimensions and parameters in the SVM. We evaluate the PSOGO-Senti model on two datasets from different fields. The experimental results showed that the PSOGO-Senti model can improve binary and multi-polarity Chinese sentiment analysis. We compared the optimal feature subset selected by PSOGO-Senti with the features in the sentiment dictionary. The results of this comparison indicated that PSOGO-Senti can effectively remove redundant and noisy features and can select a domain-specific feature subset with a higher-explanatory power for a particular sentiment analysis task. The experimental results showed that the PSOGO-Senti approach is effective and robust for sentiment analysis tasks in different domains. By comparing the improvements of two-polarity, three-polarity and five-polarity sentiment analysis results, we found that the five-polarity sentiment analysis delivered the largest improvement. The improvement of the two-polarity sentiment analysis was the smallest. We conclude that the PSOGO-Senti achieves higher improvement for a more complicated sentiment analysis task. We also compared the results of PSOGO-Senti with those of the genetic algorithm (GA) and grid search method. From the results of this comparison, we found that PSOGO-Senti is more suitable for improving a difficult multi-polarity sentiment analysis problem. PMID:25909740

  15. Characterization of Electrograms from Multipolar Diagnostic Catheters during Atrial Fibrillation

    Science.gov (United States)

    Ganesan, Prasanth; Cherry, Elizabeth M.; Pertsov, Arkady M.; Ghoraani, Behnaz

    2015-01-01

    Atrial fibrillation (AF) is the most common arrhythmia in USA with more than 2.3 million people affected annually. Catheter ablation procedure is a method for treatment of AF, which involves 3D electroanatomic mapping of the patient's left atrium (LA) by maneuvering a conventional multipolar diagnostic catheter (MPDC) along the LA endocardial surface after which pulmonary vein (PV) isolation is performed, thus eliminating the AF triggers originating from the PVs. However, it remains unclear how to effectively utilize the information provided by the MPDC to locate the AF-sustaining sites, known as sustained rotor-like activities (RotAs). In this study, we use computer modeling to investigate the variations in the characteristics of the MPDC electrograms, namely, total conduction delay (TCD) and average cycle length (CL), as the MPDC moves towards a RotA source. Subsequently, a study with a human subject was performed in order to verify the predictions of the simulation study. The conclusions from this study may be used to iteratively direct an MPDC towards RotA sources thus allowing the RotAs to be localized for customized and improved AF ablation. PMID:26581316

  16. Smoother thrust on multi-polar type linear DC motor

    Energy Technology Data Exchange (ETDEWEB)

    Wakiwaka, H.; Senoh, S.; Yajima, H; Yamada, H. [Shinshu Univ., Wakasato, Nagano (Japan). Faculty of Engineering; Oda, J. [Ohkura Electric Co., Ltd., Shirako, Wakou (Japan)

    1997-09-01

    A LDM has the merits of a high response and a direct linear motion. Therefore, a LDM is used widely in the fields of Factory Automation (FA). As compared with a mono-polar type Linear DC Motor (LDM), it is possible for a multi-polar type LDM to have a longer stroke and more thrust with thin shape. However, there are thrust ripple on multi-polar type one. In this paper, a design to prevent thrust ripple is discussed. In order to make a smoother thrust on multi-polar type LDM, the structure of the LDM is set as a 2-phase coil type. This paper clarifies that the thrust ripple of the LDM has the minimum value of 1.68%, the pole pitch of 15 mm, the coil width of 12 mm and the permanent magnet width of 10 mm.

  17. Sensing with multipolar second harmonic generation from spherical metallic nanoparticles.

    Science.gov (United States)

    Butet, Jérémy; Russier-Antoine, Isabelle; Jonin, Christian; Lascoux, Noëlle; Benichou, Emmanuel; Brevet, Pierre-François

    2012-03-14

    We show that sensing in the nonlinear optical regime using multipolar surface plasmon resonances is more sensitive in comparison to sensing in the linear optical regime. Mie theory, and its extension to the second harmonic generation from a metallic nanosphere, is used to describe multipolar second harmonic generation from silver metallic nanoparticles. The standard figure of merit of a potential plasmonic sensor based on this principle is then calculated. We finally demonstrate that such a sensor is more sensitive to optical refraction index changes occurring in the vicinity of the metallic nanoparticle than its linear counterpart. PMID:22375818

  18. Design of outer-rotor type multipolar SR motor for electric vehicle

    Science.gov (United States)

    Nakamura, Kenji; Suzuki, Yosuke; Goto, Hiroki; Ichinokura, Osamu

    2005-04-01

    In this paper, we design an outer-rotor type multipolar switched reluctance (SR) motor, and examine an application of the SR motor to an electric vehicle (EV). The design is based on a nonlinear magnetic circuit model proposed by the authors. Using the model, we can calculate dynamic characteristics of a SR motor accurately. Furthermore, by combining the nonlinear magnetic circuit model with a motor drive circuit and motion equation of an EV, we can predict dynamic characteristics such as the maximum speed, acceleration torque, and a battery current of the EV.

  19. Design of outer-rotor type multipolar SR motor for electric vehicle

    International Nuclear Information System (INIS)

    In this paper, we design an outer-rotor type multipolar switched reluctance (SR) motor, and examine an application of the SR motor to an electric vehicle (EV). The design is based on a nonlinear magnetic circuit model proposed by the authors. Using the model, we can calculate dynamic characteristics of a SR motor accurately. Furthermore, by combining the nonlinear magnetic circuit model with a motor drive circuit and motion equation of an EV, we can predict dynamic characteristics such as the maximum speed, acceleration torque, and a battery current of the EV

  20. Non-Parametric Statistical Thresholding for Sparse Magnetoencephalography Source Reconstructions

    OpenAIRE

    JuliaParsonsOwen; KensukeSekihara; SrikantanS.Nagarajan

    2012-01-01

    Uncovering brain activity from magnetoencephalography (MEG) data requires solving an ill-posed inverse problem, greatly confounded by noise, interference, and correlated sources. Sparse reconstruction algorithms, such as Champagne, show great promise in that they provide focal brain activations robust to these confounds. In this paper, we address the technical considerations of statistically thresholding brain images obtained from sparse reconstruction algorithms. The source power distributio...

  1. Complexity Measures in Magnetoencephalography: Measuring "Disorder" in Schizophrenia

    OpenAIRE

    Brookes, Matthew J; Hall, Emma L.; Robson, Siân E.; Price, Darren; Palaniyappan, Lena; Liddle, Elizabeth B.; Liddle, Peter F; Robinson, Stephen E.; Morris, Peter G.

    2015-01-01

    This paper details a methodology which, when applied to magnetoencephalography (MEG) data, is capable of measuring the spatio-temporal dynamics of ‘disorder’ in the human brain. Our method, which is based upon signal entropy, shows that spatially separate brain regions (or networks) generate temporally independent entropy time-courses. These time-courses are modulated by cognitive tasks, with an increase in local neural processing characterised by localised and transient increases in entropy ...

  2. Neural Signatures of Phonetic Learning in Adulthood: A Magnetoencephalography Study

    OpenAIRE

    Zhang, Yang; Patricia K. Kuhl; Imada, Toshiaki; Iverson, Paul; Pruitt, John; Stevens, Erica B.; Kawakatsu, Masaki; Tohkura, Yoh'ichi; Nemoto, Iku

    2009-01-01

    The present study used magnetoencephalography (MEG) to examine perceptual learning of American English /r/ and /l/ categories by Japanese adults who had limited English exposure. A training software program was developed based on the principles of infant phonetic learning, featuring systematic acoustic exaggeration, multi-talker variability, visible articulation, and adaptive listening. The program was designed to help Japanese listeners utilize an acoustic dimension relevant for phonemic cat...

  3. Magnetoencephalography: Fundamentals and Established and Emerging Clinical Applications in Radiology

    International Nuclear Information System (INIS)

    Magnetoencephalography is a noninvasive, fast, and patient friendly technique for recording brain activity. It is increasingly available and is regarded as one of the most modern imaging tools available to radiologists. The dominant clinical use of this technology currently centers on two, partly overlapping areas, namely, localizing the regions from which epileptic seizures originate, and identifying regions of normal brain function in patients preparing to undergo brain surgery. As a consequence, many radiologists may not yet be familiar with this technique. This review provides an introduction to magnetoencephalography, discusses relevant analytical techniques, and presents recent developments in established and emerging clinical applications such as pervasive developmental disorders. Although the role of magnetoencephalography in diagnosis, prognosis, and patient treatment is still limited, it is argued that this technology is exquisitely capable of contributing indispensable information about brain dynamics not easily obtained with other modalities. This, it is believed, will make this technology an important clinical tool for a wide range of disorders in the future

  4. The Shaping of the Multipolar Pre-Planetary Nebula CRL 618 by Multi-directional Bullets

    OpenAIRE

    Huang, Po-Sheng; Lee, Chin-Fei; Moraghan, Anthony; Smith, Michael

    2016-01-01

    In order to understand the formation of the multipolar structures of the pre-planetary nebula (PPN) CRL 618, we perform 3D simulations using a multi-directional bullet model. The optical lobes of CRL 618 and fast molecular outflows at the tips of the lobes have been found to have similar expansion ages of ~ 100 yr. Additional fast molecular outflows were found near the source along the outflow axes with ages of ~ 45 yr, suggesting a second episode of bullet ejections. Thus, in our simulations...

  5. Size dependence of multipolar plasmon resonance frequencies and damping rates in simple metal spherical nanoparticles

    CERN Document Server

    Derkachova, A

    2008-01-01

    Multipolar plasmon oscillation frequencies and corresponding damping rates for nanospheres formed of the simplest free-electron metals are studied. The possibility of controlling plasmon features by choosing the size and dielectric properties of the sphere surroundings is discussed. Optical properties of the studied metals are described within the Drude-Sommerfeld model of the dielectric function with effective parameters acounting for the contribution of conduction electrons and of interband transitions. No approximation is made in respect of the size of a particle; plasmon size characteristics are described rigorously. The results of our experiment on sodium nanodroplets [1] are compared with the oscillation frequency size dependence of dipole and quadrupole plasmon.

  6. Multipolar electromagnetic fields around neutron stars: exact vacuum solutions and related properties

    Science.gov (United States)

    Pétri, J.

    2015-06-01

    The magnetic field topology in the surrounding of neutron stars is one of the key questions in pulsar magnetospheric physics. A very extensive literature exists about the assumption of a dipolar magnetic field but very little progress has been made in attempts to include multipolar components in a self-consistent way. In this paper, we study the effect of multipolar electromagnetic fields anchored in the star. We give exact analytical solutions in closed form for any order l and apply them to the retarded point quadrupole (l = 2), hexapole (l = 3) and octopole (l = 4), a generalization of the retarded point dipole (l = 1). We also compare the Poynting flux from each multipole and show that the spin-down luminosity depends on the ratio R/rL, R being the neutron star radius and rL the light-cylinder radius. Therefore the braking index also depends on R/rL. As such multipole fields possess very different topology, most importantly smaller length scales compared to the dipolar field, especially close to the neutron star, we investigate the deformation of the polar caps induced by these multipolar fields. Such fields could have a strong impact on the interpretation of the pulsed radio emission suspected to emanate from these polar caps as well as on the inferred geometry deduced from the high-energy light-curve fitting and on the magnetic field strength. Discrepancies between the two-pole caustic model and our new multipole caustic model are emphasized with the quadrupole field. To this respect, we demonstrate that working with only a dipole field can be very misleading.

  7. Multipolar radiation of quantum emitters with nanowire optical antennas.

    Science.gov (United States)

    Curto, Alberto G; Taminiau, Tim H; Volpe, Giorgio; Kreuzer, Mark P; Quidant, Romain; van Hulst, Niek F

    2013-01-01

    Multipolar transitions other than electric dipoles are generally too weak to be observed at optical frequencies in single quantum emitters. For example, fluorescent molecules and quantum dots have dimensions much smaller than the wavelength of light and therefore emit predominantly as electric dipoles. Here we demonstrate controlled emission of a quantum dot into multipolar radiation through selective coupling to a linear nanowire antenna. The antenna resonance tailors the interaction of the quantum dot with light, effectively creating a hybrid nanoscale source beyond the simple Hertz dipole. Our findings establish a basis for the controlled driving of fundamental modes in nanoantennas and metamaterials, for the understanding of the coupling of quantum emitters to nanophotonic devices such as waveguides and nanolasers, and for the development of innovative quantum nano-optics components with properties not found in nature. PMID:23612291

  8. Beam engineering for selective and enhanced coupling to multipolar resonances

    Science.gov (United States)

    Das, Tanya; Iyer, Prasad P.; DeCrescent, Ryan A.; Schuller, Jon A.

    2015-12-01

    Multipolar electromagnetic phenomena in subwavelength resonators are at the heart of metamaterial science and technology. In this Rapid Communication, we demonstrate selective and enhanced coupling to specific multipole resonances via beam engineering. We first derive an analytical method for determining the scattering and absorption of spherical nanoparticles (NPs) that depends only on the local electromagnetic field quantities within an inhomogeneous beam. Using this analytical technique, we demonstrate the ability to drastically manipulate the scattering properties of a spherical NP by varying illumination properties and demonstrate the excitation of a longitudinal quadrupole mode that cannot be accessed with conventional illumination. This work enhances the understanding of fundamental light-matter interactions in metamaterials and lays the foundation for researchers to identify, quantify, and manipulate multipolar light-matter interactions through optical beam engineering.

  9. Beam engineering for selective and enhanced coupling to multipolar resonances

    CERN Document Server

    Das, Tanya; Schuller, Jon A

    2015-01-01

    Multipolar electromagnetic phenomena in sub-wavelength resonators are at the heart of metamaterial science and technology. In this letter, we demonstrate selective and enhanced coupling to specific multipole resonances via beam engineering. We first derive an analytical method for determining the scattering and absorption of spherical nanoparticles (NPs) that depends only on the local electromagnetic field quantities within an inhomogeneous beam. Using this analytical technique, we demonstrate the ability to drastically manipulate the scattering properties of a spherical NP by varying illumination properties and demonstrate the excitation of a longitudinal quadrupole mode that cannot be accessed with conventional illumination. This work enhances the understanding of fundamental light-matter interactions in metamaterials, and lays the foundation for researchers to identify, quantify, and manipulate multipolar light-matter interactions through optical beam engineering.

  10. Multipolar test body equations of motion in generalized gravity theories

    OpenAIRE

    Obukhov, Yuri N.; Puetzfeld, Dirk

    2015-01-01

    We give an overview of the derivation of multipolar equations of motion of extended test bodies for a wide set of gravitational theories beyond the standard general relativistic framework. The classes of theories covered range from simple generalizations of General Relativity, e.g. encompassing additional scalar fields, to theories with additional geometrical structures which are needed for the description of microstructured matter. Our unified framework even allows to handle theories with no...

  11. Multipolar equations of motion for extended test bodies in general relativity

    International Nuclear Information System (INIS)

    We derive the equations of motion of an extended test body in the context of Einstein's theory of gravitation. The equations of motion are obtained via a multipolar approximation method and are given up to the quadrupolar order. Special emphasis is put on the explicit construction of the so-called canonical form of the energy-momentum density. The set of gravitational multipolar moments and the corresponding equations of motion allow for a systematic comparison to competing multipolar approximation schemes.

  12. Tailoring unidirectional angular radiation through multipolar interference in a single-element subwavelength all-dielectric stair-like nanoantenna.

    Science.gov (United States)

    Tian, Jingyi; Li, Qiang; Yang, Yuanqing; Qiu, Min

    2016-02-11

    The study of all-dielectric nanoantennas has become an emerging branch of the study of optical nanoantennas in recent years, with all-dielectric nanoantennas having an outstanding ability to tailor forward and backward unidirectional scattering arising from interference mainly between electric dipoles and magnetic dipoles induced simultaneously inside a nanoparticle. To further control their radiation properties, we demonstrate the off-normal scattering, by a silicon stair-like nanoantenna, of an incident near-infrared plane wave due to multipolar interference. The radiation angle could be tailored over a 20-degree range by tuning the geometric parameters of the nanoantenna. A multipolar model was adopted to interpret the interference among one electric dipole, two magnetic dipoles and one electric quadrupole induced inside the nanoantenna. The maximum radiation angle reached 20° at a wavelength near 1550 nm. Such a stair-like nanoantenna sets a good example for further flexible manipulation of multipolar resonances inside all-dielectric nanoparticles, which is an essential step towards practical application of all-dielectric nanoantennas in the near future. PMID:26817668

  13. Ab initio derivation of multipolar expansion of optical force

    CERN Document Server

    Jiang, Yikun; Lin, Zhifang

    2015-01-01

    Like many other physical quantities, the optical force can be expanded using multipole expansion, which has been done in [Nat. Photon. 5, 531], up to electric octupole order. However, in that study, the existence of radiation multipoles were pre-assumed, and the role of the fundamental building units, charges, are not evident. Here, we derive the same multipolar expression of optical force by treating the particles as a collection of point charges or point dipoles, which results in more transparent physics and mathematics.

  14. BRICS and the myth of the multipolar world

    Directory of Open Access Journals (Sweden)

    Takis Fotopoulos

    2014-12-01

    Full Text Available The aim of this article is to show that the BRICS countries not only don’t form part of a multi-polar world, but in reality are far from sovereign states in any sense of the word. In fact, if their real goal was indeed the creation of an alternative pole of sovereign nation-states, they should have planned at the outset to break their direct dependence on the globalized capitalist market economy, cutting their ties with global institutions controlled by the Transnational Elite (WTO, IMF and World Bank, and moving towards self-reliant economies, so that they could regain their sovereignty.

  15. First-Principles Theory of Multipolar Order in Neptunium Dioxide

    OpenAIRE

    Suzuki, Michi-To; Magnani, Nicola; Oppeneer, Peter M.

    2010-01-01

    We provide a first-principle, materials-specific theory of multipolar order and superexchange in NpO$_2$ by means of a non-collinear local-density approximation +$U$ (LDA+$U$) method. Our calculations offer a precise microscopic description of the triple-$q$-antiferro ordered phase in the absence of any dipolar moment. We find that, while the most common non-dipolar degrees of freedom (e.g., electric quadrupoles and magnetic octupoles) are active in the ordered phase, both the usually neglect...

  16. Comparisons of wind speed retrieval methods on C-band multi-polarization SAR measurements

    Science.gov (United States)

    Ren, Lin; Yang, Jingsong; Zheng, Gang; Wang, Juan; Wang, Difeng

    2014-10-01

    This paper compares the wind speed retrieval methods on C-band multi-polarization SAR measurements to find out the most appropriate one for each polarization data. The RADARSAT-2 SAR quad-polarization (VV+HH+VH+HV) data and NDBC buoy wind data were collocated. For VVpolarization, the retrieved wind speed are compared among four geophysical model function (GMF). For HH polarization, the retrieved wind speed are compared among four polarization ratio model (PR) based on CMOD5 GMF. For VH polarization, the retrieved wind speed are compared between two linear models. Comparisons show all of three polarimetric SAR data have the ability of retrieving wind speed. Based on the error analysis, the commendatory methods are proposed for each polarization.

  17. Note: Optical receiver system for 152-channel magnetoencephalography

    International Nuclear Information System (INIS)

    An optical receiver system composing 13 serial data restore/synchronizer modules and a single module combiner converted optical 32-bit serial data into 32-bit synchronous parallel data for a computer to acquire 152-channel magnetoencephalography (MEG) signals. A serial data restore/synchronizer module identified 32-bit channel-voltage bits from 48-bit streaming serial data, and then consecutively reproduced 13 times of 32-bit serial data, acting in a synchronous clock. After selecting a single among 13 reproduced data in each module, a module combiner converted it into 32-bit parallel data, which were carried to 32-port digital input board in a computer. When the receiver system together with optical transmitters were applied to 152-channel superconducting quantum interference device sensors, this MEG system maintained a field noise level of 3 fT/?Hz @ 100 Hz at a sample rate of 1 kSample/s per channel

  18. Note: Optical receiver system for 152-channel magnetoencephalography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jin-Mok; Kwon, Hyukchan; Yu, Kwon-kyu; Lee, Yong-Ho; Kim, Kiwoong [Center for Biosignals, Korea Research Institute of Standards and Science, Daejeon 305-600 (Korea, Republic of)

    2014-11-15

    An optical receiver system composing 13 serial data restore/synchronizer modules and a single module combiner converted optical 32-bit serial data into 32-bit synchronous parallel data for a computer to acquire 152-channel magnetoencephalography (MEG) signals. A serial data restore/synchronizer module identified 32-bit channel-voltage bits from 48-bit streaming serial data, and then consecutively reproduced 13 times of 32-bit serial data, acting in a synchronous clock. After selecting a single among 13 reproduced data in each module, a module combiner converted it into 32-bit parallel data, which were carried to 32-port digital input board in a computer. When the receiver system together with optical transmitters were applied to 152-channel superconducting quantum interference device sensors, this MEG system maintained a field noise level of 3 fT/?Hz @ 100 Hz at a sample rate of 1 kSample/s per channel.

  19. [Temporal lobe seizure recorded by magnetoencephalography: case report].

    Science.gov (United States)

    Amo, Carlos; Santiuste, Marta; Maestú, Fernando; Fernández, Alberto; Egatz, Renata; González-Hidalgo, Mercedes; Saldaña, Cristóbal; Sáiz, Antonio; Ortiz, Tomás

    2004-09-01

    Ictal onset localization is a important factor in presurgical evaluation of epilepsy. This paper describes the localization of a seizure onset recorded by magnetoencephalography (MEG) from a 12-year-old male patient who suffered from complex partial drug-resistant seizures. MRI revealed a 20mm diameter lesion located in left hippocampus. Scalp EEG showed left temporal theta waves. Interictal MEG registrations detected isolated spike-wave activity posterior and inferior to the MRI lesion. Ictal MEG showed continuous spike-wave activity (2 Hz). Dipole localization sited seizure onset in the inferior left temporal gyrus, the same localization of the interictal MEG activity. This ictal activity spreads bilaterally to frontal areas. Intrasurgical electrocorticography recording confirmed interictal MEG results. PMID:15334242

  20. The Role of Angular Momentum in the Construction of Electromagnetic Multipolar Fields

    Science.gov (United States)

    Tischler, Nora; Zambrana-Puyalto, Xavier; Molina-Terriza, Gabriel

    2012-01-01

    Multipolar solutions of Maxwell's equations are used in many practical applications and are essential for the understanding of light-matter interactions at the fundamental level. Unlike the set of plane wave solutions of electromagnetic fields, the multipolar solutions do not share a standard derivation or notation. As a result, expressions…

  1. Multichannel System Based on a High Sensitivity Superconductive Sensor for Magnetoencephalography

    Directory of Open Access Journals (Sweden)

    Sara Rombetto

    2014-07-01

    Full Text Available We developed a multichannel system based on superconducting quantum interference devices (SQUIDs for magnetoencephalography measurements. Our system consists of 163 fully-integrated SQUID magnetometers, 154 channels and 9 references, and all of the operations are performed inside a magnetically-shielded room. The system exhibits a magnetic field noise spectral density of approximatively 5 fT/Hz1=2. The presented magnetoencephalography is the first system working in a clinical environment in Italy.

  2. Magnetar Giant Flares --- Flux Rope Eruptions in Multipolar Magnetospheric Magnetic Fields

    CERN Document Server

    Yu, Cong

    2012-01-01

    We address a primary question regarding the physical mechanism that triggers the energy release and initiates the onset of eruptions in the magnetar magnetosphere. A self-consistent stationary, axisymmetric model of the magnetar magnetosphere is constructed based on a force-free magnetic field configuration which contains a helically twisted force-free flux rope. Given the complex multipolar magnetic fields at the magnetar surface, we also develop a convenient numerical scheme to solve the GS equation. Depending on the surface magnetic field polarity, there exist two kinds of magnetic field configurations, inverse and normal. For these two kinds of configurations, variations of the flux rope equilibrium height in response to gradual surface physical processes, such as flux injections and crust motions, are carefully examined. We find that equilibrium curves contain two branches, one represents a stable equilibrium branch, the other an unstable equilibrium branch. As a result, the evolution of the system shows...

  3. Multipolar interference for non-reciprocal nonlinear generation

    CERN Document Server

    Poutrina, Ekaterina

    2015-01-01

    We show that nonlinear multipolar interference allows achieving not only unidirectional, but also non-reciprocal nonlinear generation from a nanoelement, with the direction of the nonlinearly produced light decoupled from that of at least one or several of the excitation beams. Alternatively, it may allow inhibiting the specified nonlinear response in a nanoelement or in its periodic arrangement by reversing the direction of one of the pumps. The described phenomena exploit the fact that, contrary to the linear response case, nonlinear magneto-electric interference stems from a combination of additive and multiplicative processes and includes an interference between various terms within the electric and magnetic partial waves themselves. We demonstrate the introduced concept numerically using an example of a plasmonic dimer geometry with realistic material parameters.

  4. Multipolar Black Body Radiation Shifts for the Single Ion Clocks

    CERN Document Server

    Arora, Bindiya; Sahoo, B K

    2011-01-01

    Appraising the projected $10^{-18}$ fractional uncertainty in the optical frequency standards using singly ionized ions, we estimate the black-body radiation (BBR) shifts due to the magnetic dipole (M1) and electric quadrupole (E2) multipoles of the magnetic and electric fields, respectively. Multipolar scalar polarizabilities are determined for the singly ionized calcium (Ca$^+$) and strontium (Sr$^+$) ions using the relativistic coupled-cluster method; though the theory can be exercised for any single ion clock proposal. The expected energy shifts for the respective clock transitions are estimated to be $4.38(3) \\times 10^{-4}$ Hz for Ca$^+$ and $9.50(7) \\times 10^{-5}$ Hz for Sr$^+$. These shifts are large enough and may be prerequisite for the frequency standards to achieve the foreseen $10^{-18}$ precision goal.

  5. Simulated multipolarized MAPSAR images to distinguish agricultural crops

    Directory of Open Access Journals (Sweden)

    Wagner Fernando Silva

    2012-06-01

    Full Text Available Many researchers have shown the potential of Synthetic Aperture Radar (SAR images for agricultural applications, particularly for monitoring regions with limitations in terms of acquiring cloud free optical images. Recently, Brazil and Germany began a feasibility study on the construction of an orbital L-band SAR sensor referred to as MAPSAR (Multi-Application Purpose SAR. This sensor provides L-band images in three spatial resolutions and polarimetric, interferometric and stereoscopic capabilities. Thus, studies are needed to evaluate the potential of future MAPSAR images. The objective of this study was to evaluate multipolarized MAPSAR images simulated by the airborne SAR-R99B sensor to distinguish coffee, cotton and pasture fields in Brazil. Discrimination among crops was evaluated through graphical and cluster analysis of mean backscatter values, considering single, dual and triple polarizations. Planting row direction of coffee influenced the backscatter and was divided into two classes: parallel and perpendicular to the sensor look direction. Single polarizations had poor ability to discriminate the crops. The overall accuracies were less than 59 %, but the understanding of the microwave interaction with the crops could be explored. Combinations of two polarizations could differentiate various fields of crops, highlighting the combination VV-HV that reached 78 % overall accuracy. The use of three polarizations resulted in 85.4 % overall accuracy, indicating that the classes pasture and parallel coffee were fully discriminated from the other classes. These results confirmed the potential of multipolarized MAPSAR images to distinguish the studied crops and showed considerable improvement in the accuracy of the results when the number of polarizations was increased.

  6. Simulated multipolarized MAPSAR images to distinguish agricultural crops

    Scientific Electronic Library Online (English)

    Wagner Fernando, Silva; Bernardo Friedrich Theodor, Rudorff; Antonio Roberto, Formaggio; Waldir Renato, Paradella; José Claudio, Mura.

    2012-06-01

    Full Text Available Many researchers have shown the potential of Synthetic Aperture Radar (SAR) images for agricultural applications, particularly for monitoring regions with limitations in terms of acquiring cloud free optical images. Recently, Brazil and Germany began a feasibility study on the construction of an orb [...] ital L-band SAR sensor referred to as MAPSAR (Multi-Application Purpose SAR). This sensor provides L-band images in three spatial resolutions and polarimetric, interferometric and stereoscopic capabilities. Thus, studies are needed to evaluate the potential of future MAPSAR images. The objective of this study was to evaluate multipolarized MAPSAR images simulated by the airborne SAR-R99B sensor to distinguish coffee, cotton and pasture fields in Brazil. Discrimination among crops was evaluated through graphical and cluster analysis of mean backscatter values, considering single, dual and triple polarizations. Planting row direction of coffee influenced the backscatter and was divided into two classes: parallel and perpendicular to the sensor look direction. Single polarizations had poor ability to discriminate the crops. The overall accuracies were less than 59 %, but the understanding of the microwave interaction with the crops could be explored. Combinations of two polarizations could differentiate various fields of crops, highlighting the combination VV-HV that reached 78 % overall accuracy. The use of three polarizations resulted in 85.4 % overall accuracy, indicating that the classes pasture and parallel coffee were fully discriminated from the other classes. These results confirmed the potential of multipolarized MAPSAR images to distinguish the studied crops and showed considerable improvement in the accuracy of the results when the number of polarizations was increased.

  7. [Investigation of the Cerebral Cortex Using Magnetoencephalography(MEG)].

    Science.gov (United States)

    Kakigi, Ryusuke

    2015-04-01

    Cortical neurons are excited by signals from the thalamus that are conducted via thalamocortical fibers. As the cortex receives these signals, electric currents are conducted through the apical dendrites of pyramidal cells in the cerebral cortex. These electric currents generate magnetic fields. These electric and magnetic currents can be recorded by electroencephalography (EEG) and magnetoencephalography (MEG), respectively. The spatial resolution of MEG is higher than that of EEG because magnetic fields, unlike electric fields, are not affected by current conductivity. MEG also has several advantages over functional magnetic resonance imaging (fMRI). It (1) is completely non-invasive; (2) measures neuronal activity rather than blood flow or metabolic changes; (3) has a higher temporal resolution than fMRI on the order of milliseconds; (4) enables the measurement of stimulus-evoked and event-related responses; (5) enables the analysis of frequency (i.e., brain rhythm) response, which means that physiological changes can be analyzed spatiotemporally; and (6) enables the detailed analysis of results from an individual subject, which eliminates the need to average results over several subjects. This latter advantage of MEG therefore enables the analysis of inter-individual differences. PMID:25846594

  8. Noise-free magnetoencephalography recordings of brain function

    International Nuclear Information System (INIS)

    Perhaps the greatest impediment to acquiring high-quality magnetoencephalography (MEG) recordings is the ubiquitous ambient magnetic field noise. We have designed and built a whole-head MEG system using a helmet-like superconducting imaging surface (SIS) surrounding the array of superconducting quantum interference device (SQUID) magnetometers used to measure the MEG signal. We previously demonstrated that the SIS passively shields the SQUID array from ambient magnetic field noise, independent of frequency, by 25-60 dB depending on sensor location. SQUID 'reference sensors' located on the outside of the SIS helmet measure ambient magnetic fields in very close proximity to the MEG magnetometers while being nearly perfectly shielded from all sources in the brain. The fact that the reference sensors measure no brain signal yet are located in close proximity to the MEG sensors enables very accurate estimation and subtraction of the ambient field noise contribution to the MEG sensors using an adaptive algorithm. We have demonstrated total ambient noise reduction factors in excess of 106 (>120 dB). The residual noise for most MEG SQUID channels is at or near the intrinsic SQUID noise floor, typically 2-3 f T Hz-1/2. We are recording MEG signals with greater signal-to-noise than equivalent EEG measurements

  9. Simultaneous magnetoencephalography and intracranial EEG registration: technical and clinical aspects.

    Science.gov (United States)

    Santiuste, Marta; Nowak, Rafal; Russi, Antonio; Tarancon, Thais; Oliver, Bartolome; Ayats, Emilio; Scheler, Gabriela; Graetz, Galleon

    2008-12-01

    The purpose of this study was to describe the methodology necessary for simultaneous recording of intracranial EEG (ICEEG) and magnetoencephalography (MEG) and to assess the sensitivity of whole-head MEG versus depth electrode EEG in the detection and localization of epileptic spikes. Interictal MEG and depth electrode activities from the temporal mesial and occipital lobes were simultaneously recorded from four candidates for epilepsy surgery. Implanted depth electrodes identified neocortical and mesial structures of ictal onset. Interictal spikes detected by these same depth electrodes were compared with simultaneous MEG events. MEG detections of ICEEG spikes, ICEEG versus MEG spike amplitudes, number of ICEEG contacts involved in the spike, and anatomic locations of MEG equivalent current dipoles were analyzed. MEG detected and localized 95% of the neocortical spikes, but only 25% to 60% of spikes from mesial structures. Mesial temporal spikes resulted in lower MEG spike amplitudes, when compared with neocortical spikes. Equivalent current dipoles of MEG spikes localized to the ictal onset zones in all four patients. MEG can detect and localize interictal epileptiform spikes that are recorded from depth electrodes in both neocortical and mesial structures, despite the lesser amplitude of spikes of mesial origin. PMID:18997623

  10. A Self-shielded Magnetometer-in-vacuum Magnetoencephalography System

    Directory of Open Access Journals (Sweden)

    Yong-Ho Lee

    2010-04-01

    Full Text Available The aim of this study is to develop a high-sensitivity and economic magnetoencephalography (MEG system. We developed a whole-head 150-channel MEG system having magnetometers installed in the vacuum space of the dewar, and magnetometers shielded from the external noises using a superconductive shield helmet. To reduce the heat input from the dewar neck, the neck diameter (100 mm was made much smaller than the inner diameter (480 mm of the dewar bottom. The sensing magnetometers were installed in the vacuum space of the helium dewar (helmet inside, and signal wires were introduced through the top plate of the dewar. Inside the helium reservoir, only reference channels and transfer port were installed. The reference channels positioned outside of the helmet reservoir measure environmental noises. A superconductive plate made of Pb was placed on the surface of helmet surface in the He reservoir. This shielding helmet protects the sensing magnetometers from the environmental noises, and it protects reference channels from the brain magnetic fields. The result is that the reference channels measures environmental noises only, and software gradiometer can be applied to further reduce the external noises. Shielding factors of the shield helmet are in the range of 10-500, depending on the position inside the helmet and noise direction. Operation of the MEG system was done inside a moderately shielded room. Signal-to-noise ratio of the auditory-evoked signal measured with the door of the shielded room open was nearly the same as that measured with the door open.

  11. Categorical Discrimination of Human Body Parts by Magnetoencephalography

    Directory of Open Access Journals (Sweden)

    Misaki Nakamura

    2015-11-01

    Full Text Available Humans recognize body parts in categories. Previous studies have shown that responses in the fusiform body area (FBA and extrastriate body area (EBA are evoked by the perception of the human body, when presented either as whole or as isolated parts. These responses occur approximately 190 ms after body images are visualized. The extent to which body-sensitive responses show specificity for different body part categories remains to be largely clarified. We used a decoding method to quantify neural responses associated with the perception of different categories of body parts. Nine subjects underwent measurements of their brain activities by magnetoencephalography (MEG while viewing 14 images of feet, hands, mouths, and objects. We decoded categories of the presented images from the MEG signals using a support vector machine (SVM and calculated their accuracy by 10-fold cross-validation. For each subject, a response that appeared to be a body-sensitive response was observed and the MEG signals corresponding to the three types of body categories were classified based on the signals in the occipitotemporal cortex. The accuracy in decoding body-part categories (with a peak at approximately 48% was above chance (33.3% and significantly higher than that for random categories. According to the time course and location, the responses are suggested to be body-sensitive and to include information regarding the body-part category. Finally, this noninvasive method can decode category information of a visual object with high temporal and spatial resolution and this result may have a significant impact in the field of brain–machine interface research.

  12. Categorical discrimination of human body parts by magnetoencephalography

    Science.gov (United States)

    Nakamura, Misaki; Yanagisawa, Takufumi; Okamura, Yumiko; Fukuma, Ryohei; Hirata, Masayuki; Araki, Toshihiko; Kamitani, Yukiyasu; Yorifuji, Shiro

    2015-01-01

    Humans recognize body parts in categories. Previous studies have shown that responses in the fusiform body area (FBA) and extrastriate body area (EBA) are evoked by the perception of the human body, when presented either as whole or as isolated parts. These responses occur approximately 190 ms after body images are visualized. The extent to which body-sensitive responses show specificity for different body part categories remains to be largely clarified. We used a decoding method to quantify neural responses associated with the perception of different categories of body parts. Nine subjects underwent measurements of their brain activities by magnetoencephalography (MEG) while viewing 14 images of feet, hands, mouths, and objects. We decoded categories of the presented images from the MEG signals using a support vector machine (SVM) and calculated their accuracy by 10-fold cross-validation. For each subject, a response that appeared to be a body-sensitive response was observed and the MEG signals corresponding to the three types of body categories were classified based on the signals in the occipitotemporal cortex. The accuracy in decoding body-part categories (with a peak at approximately 48%) was above chance (33.3%) and significantly higher than that for random categories. According to the time course and location, the responses are suggested to be body-sensitive and to include information regarding the body-part category. Finally, this non-invasive method can decode category information of a visual object with high temporal and spatial resolution and this result may have a significant impact in the field of brain–machine interface research. PMID:26582986

  13. Multipolar effects on the dipolar polarizability of magneto-electric antennas.

    Science.gov (United States)

    Varault, S; Rolly, B; Boudarham, G; Demésy, G; Stout, B; Bonod, N

    2013-07-15

    We show the important role played by the multipolar coupling between the illuminating field and magneto-electric scatterers even in the small particle limit (?/10). A general multipolar method is presented which, for the case of planar non centrosymmetric particles, generates a simple expression for the polarizability tensor that directly links the dipolar moment to the incident field. The relevancy of this approach is demonstrated by comparing thoroughly the dipolar moments predicted by the method with full numerical calculations. PMID:23938495

  14. Vegetation canopy discrimination and biomass assessment using multipolarized airborne SAR

    Science.gov (United States)

    Ulaby, F. T.; Dobson, M. C.; Held, D. N.

    1985-01-01

    Multipolarized airborne Synthetic Aperture Radar (SAR) data were acquired over a largely agricultural test site near Macomb, Illinois, in conjunction with the Shuttle Imaging Radar (SIR-B) experiment in October 1984. The NASA/JPL L-band SAR operating at 1.225 GHz made a series of daily overflights with azimuth view angles both parallel and orthogonal to those of SIR-B. The SAR data was digitally recorded in the quadpolarization configuration. An extensive set of ground measurements were obtained throughout the test site and include biophysical and soil measurements of approximately 400 agricultural fields. Preliminary evaluation of some of the airborne SAR imagery indicates a great potential for crop discrimination and assessment of canopy condition. False color composites constructed from the combination of three linear polarizations (HH, VV, and HV) were found to be clearly superior to any single polarization for purposes of crop classification. In addition, an image constructed using the HH return to modulate intensity and the phase difference between HH and VV returns to modulate chroma indicates a clear capability for assessment of canopy height and/or biomass. In particular, corn fields heavily damaged by infestations of corn borer are readily distinguished from noninfested fields.

  15. Potential applications of multipolarization SAR for pine plantation biomass estimation

    Science.gov (United States)

    Wu, S. T.

    1985-01-01

    This study was conducted as a part of the research tasks under the Radar Land Cover Analysis Program. The Radar Land Cover Analysis objective is, through utilization of multisensor data, to gain a basic understanding of the measurements and data characteristics in the visible-IR-microwave regions of the electromagnetic spectrum associated with specific surface features and cover types. Since the results of analysis of data acquired by Shuttle Imaging Radar (SIR-A) and LANDSAT Thematic Mapper (TM) over the study area were reported (NSTL/ERL Report No. 228, December 1984), this study focused on the analysis and evaluation of the L-band multipolarization airborne SAR data acquired over a southeastern pine forest scene. The data acquisition mission was flown on September 8 and 9, 1983. The HH, HV polarizations and the VV, VH polarizations were used on the first and the second day, respectively. Due to instrumentation difficulties, the digital recorder recorded only the second day's data. Because of this, only the VV and VH polarization data were used in this analysis. However, the HH and HV polarization images were available for visual comparison. It appears that SAR digital numbers correlate with the index of green biomass.

  16. Electrophysiological channel interactions using focused multipolar stimulation for cochlear implants

    Science.gov (United States)

    George, Shefin S.; Shivdasani, Mohit N.; Wise, Andrew K.; Shepherd, Robert K.; Fallon, James B.

    2015-12-01

    Objective. Speech intelligibility with existing multichannel cochlear implants (CIs) is thought to be limited by poor spatial selectivity and interactions between CI channels caused by overlapping activation with monopolar (MP) stimulation. Our previous studies have shown that focused multipolar (FMP) and tripolar (TP) stimulation produce more restricted neural activation in the inferior colliculus (IC), compared to MP stimulation. Approach. This study explored interactions in the IC produced by simultaneous stimulation of two CI channels. We recorded multi-unit neural activity in the IC of anaesthetized cats with normal and severely degenerated spiral ganglion neuron populations in response to FMP, TP and MP stimulation from a 14 channel CI. Stimuli were applied to a ‘fixed’ CI channel, chosen toward the middle of the cochlear electrode array, and the effects of simultaneously stimulating a more apical ‘test’ CI channel were measured as a function of spatial separation between the two stimulation channels and stimulus level of the fixed channel. Channel interactions were quantified by changes in neural responses and IC threshold (i.e., threshold shift) elicited by simultaneous stimulation of two CI channels, compared to stimulation of the test channel alone. Main results. Channel interactions were significantly lower for FMP and TP than for MP stimulation (p < 0.001), whereas no significant difference was observed between FMP and TP stimulation. With MP stimulation, threshold shifts increased with decreased inter-electrode spacing and increased stimulus levels of the fixed channel. For FMP and TP stimulation, channel interactions were found to be similar for different inter-electrode spacing and stimulus levels of the fixed channel. Significance. The present study demonstrates how the degree of channel interactions in a CI can be controlled using stimulation configurations such as FMP and TP; such knowledge is essential in enhancing CI function in complex acoustic environments.

  17. Between thought and expression, a magnetoencephalography study of the "tip-of-the-tongue" phenomenon.

    Science.gov (United States)

    Resnik, Karmen; Bradbury, David; Barnes, Gareth R; Leff, Alex P

    2014-10-01

    "Tip-of-the-tongue" (TOT) is the phenomenon associated with the inaccessibility of a known word from memory. It is universally experienced, increases in frequency with age, and is most common for proper nouns. It is a good model for the symptom of anomia experienced much more frequently by some aphasic patients following brain injury. Here, we induced the TOT state in older participants while they underwent brain scanning with magnetoencephalography to investigate the changes in oscillatory brain activity associated with failed retrieval of known words. Using confrontation naming of pictures of celebrities, we successfully induced the TOT state in 29% of trials and contrasted it with two other states: "Know" where the participants both correctly recognized the celebrity's face and retrieved their name and "Don't Know" when the participants did not recognize the celebrity. We wished to test Levelt's influential model of speech output by carrying out two analyses, one epoching the data to the point in time when the picture was displayed and the other looking back in time from when the participants first articulated their responses. Our main findings supported the components of Levelt's model, but not their serial activation over time as both semantic and motor areas were identified in both analyses. We also found enduring decreases in the alpha frequency band in the left ventral temporal region during the TOT state, suggesting ongoing semantic search. Finally, we identified reduced beta power in classical peri-sylvian language areas for the TOT condition, suggesting that brain regions that encode linguistic memories are also involved in their attempted retrieval. PMID:24673407

  18. Increases in Language Lateralization in Normal Children as Observed Using Magnetoencephalography

    Science.gov (United States)

    Ressel, Volker; Wilke, Marko; Lidzba, Karen; Lutzenberger, Werner; Krageloh-Mann, Ingeborg

    2008-01-01

    Previous functional magnetic resonance imaging (fMRI) studies investigating hemispheric dominance for language have shown that hemispheric specialization increases with age. We employed magnetoencephalography (MEG) to investigate these effects as a function of normal development. In sum, 22 healthy children aged 7-16 years were investigated using…

  19. The Shaping of the Multipolar Pre-Planetary Nebula CRL 618 by Multi-directional Bullets

    CERN Document Server

    Huang, Po-Sheng; Moraghan, Anthony; Smith, Michael

    2016-01-01

    In order to understand the formation of the multipolar structures of the pre-planetary nebula (PPN) CRL 618, we perform 3D simulations using a multi-directional bullet model. The optical lobes of CRL 618 and fast molecular outflows at the tips of the lobes have been found to have similar expansion ages of ~ 100 yr. Additional fast molecular outflows were found near the source along the outflow axes with ages of ~ 45 yr, suggesting a second episode of bullet ejections. Thus, in our simulations, two episodes of bullet ejections are assumed. The shaping process is simulated using the ZEUS-3D hydrodynamics code that includes molecular and atomic cooling. In addition, molecular chemistry is also included to calculate the CO intensity maps. Our results show the following: (1) Multi-epoch bullets interacting with the toroidal dense core can produce the collimated multiple lobes as seen in CRL 618. The total mass of the bullets is ~ 0.034 solar mass, consistent with the observed high-velocity CO emission in fast mole...

  20. Magnetar Giant Flares in Multipolar Magnetic Fields --- II. Flux Rope Eruptions With Current Sheets

    CERN Document Server

    Huang, Lei

    2014-01-01

    We propose a physical mechanism to explain giant flares and radio afterglows in terms of a magnetospheric model containing both a helically twisted flux rope and a current sheet (CS). With the appearance of CS, we solve a mixed boundary value problem to get the magnetospheric field based on a domain decomposition method. We investigate properties of the equilibrium curve of the flux rope when the CS is present in background multipolar fields. In response to the variations at the magnetar surface, it quasi-statically evolves in stable equilibrium states. The loss of equilibrium occurs at a critical point and, beyond that point, it erupts catastrophically. New features show up when the CS is considered. Especially, we find two kinds of physical behaviors, i.e., catastrophic state transition and catastrophic escape. Magnetic energy would be released during state transitions. The released magnetic energy is sufficient to drive giant flares. The flux rope would go away from the magnetar quasi-statically, which is ...

  1. Potential application of multipolarization SAR for pine-plantation biomass estimation

    Science.gov (United States)

    Wu, Shih-Tseng

    1987-01-01

    This paper presents the technique and the potential utility of multipolarization Synthetic Aperture Radar (SAR) data for pine-plantation biomass estimation. Three channels of SAR data, one from the Shuttle Imaging Radar SIR-A and the other two from the aircraft SAR, were acquired over the Baldwin County, Alabama, study area. The SIR-A data were acquired with HH polarization and the aircraft SAR data with VV and VH polarizations. Linear regression techniques are used to estimate the pine-plantation biomass, tree height, and age using 21 test plots. The results indicate that the multipolarization data are highly related to the plantation biomass. The results suggest a potential application of multipolarization SAR for pine-plantation biomass estimation.

  2. The role of angular momentum in the construction of electromagnetic multipolar fields

    International Nuclear Information System (INIS)

    Multipolar solutions of Maxwell’s equations are used in many practical applications and are essential for the understanding of light-matter interactions at the fundamental level. Unlike the set of plane wave solutions of electromagnetic fields, the multipolar solutions do not share a standard derivation or notation. As a result, expressions originating from different derivations can be difficult to compare. Some of the derivations of the multipolar solutions do not explicitly show their relation to the angular momentum operators, thus hiding important properties of these solutions. In this paper, the relation between two of the most common derivations of this set of solutions is explicitly shown and their relation to the angular momentum operators is exposed. (paper)

  3. The role of angular momentum in the construction of electromagnetic multipolar fields

    CERN Document Server

    Tischler, Nora; Molina-Terriza, Gabriel

    2015-01-01

    Multipolar solutions of Maxwell's equations are used in many practical applications and are essential for the understanding of light-matter interactions at the fundamental level. Unlike the set of plane wave solutions of electromagnetic fields, the multipolar solutions do not share a standard derivation or notation. As a result, expressions originating from different derivations can be difficult to compare. Some of the derivations of the multipolar solutions do not explicitly show their relation to the angular momentum operators, thus hiding important properties of these solutions. In this article, the relation between two of the most common derivations of this set of solutions is explicitly shown and their relation to the angular momentum operators is exposed.

  4. Assessment of cortical dysfunction in human strabismic amblyopia using magnetoencephalography (MEG)

    International Nuclear Information System (INIS)

    The aim of this study was to use the technique of magnetoencephalography (MEG) to determine the effects of strabismic amblyopia on the processing of spatial information within the occipital cortex of humans. We recorded evoked magnetic responses to the onset of a chromatic (red/green) sinusoidal grating of periodicity 0.5-4.0 c deg-1 using a 19-channel SQUID-based neuromagnetometer. Evoked responses were recorded monocularly on six amblyopes and six normally-sighted controls, the stimuli being positioned near the fovea in the lower right visual field of each observer. For comparison, the spatial contrast sensitivity function (CSF) for the detection of chromatic gratings was measured for one amblyope and one control using a two alternate forced-choice psychophysical procedure. We chose red/green sinusoids as our stimuli because they evoke strong magnetic responses from the occipital cortex in adult humans (Fylan, Holliday, Singh, Anderson and Harding. (1997). Neuroimage, 6, 47-57). Magnetic field strength was plotted as a function of stimulus spatial frequency for each eye of each subject. Interocular differences were only evident within the amblyopic group: for stimuli of 1-2 c deg-1, the evoked responses had significantly longer latencies and reduced amplitudes through the amblyopic eye (P<0.05). Importantly, the extent of the deficit was uncorrelated with either Snellen acuity or contrast sensitivity. Localization of the evoked responses was performed using a single equivalent current dipole model. Source localizations, for both normal and amblyopic subjects, were consistent with neural activity at the occipital pole near the V1/V2 border. We conclude that MEG is sensitive to the deficit in cortical processing associated with human amblyopia, and can be used to make quantitative neurophysiological measurements. The nature of the cortical deficit is discussed. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

  5. Forest biomass, canopy structure, and species composition relationships with multipolarization L-band synthetic aperture radar data

    Science.gov (United States)

    Sader, Steven A.

    1987-01-01

    The effect of forest biomass, canopy structure, and species composition on L-band synthetic aperature radar data at 44 southern Mississippi bottomland hardwood and pine-hardwood forest sites was investigated. Cross-polarization mean digital values for pine forests were significantly correlated with green weight biomass and stand structure. Multiple linear regression with five forest structure variables provided a better integrated measure of canopy roughness and produced highly significant correlation coefficients for hardwood forests using HV/VV ratio only. Differences in biomass levels and canopy structure, including branching patterns and vertical canopy stratification, were important sources of volume scatter affecting multipolarization radar data. Standardized correction techniques and calibration of aircraft data, in addition to development of canopy models, are recommended for future investigations of forest biomass and structure using synthetic aperture radar.

  6. Turkey’s multi-polar diplomacy on its way to the European Union

    Directory of Open Access Journals (Sweden)

    Lika Mkrtchyan

    2011-12-01

    Full Text Available Turkey conducts a multi-polar foreign diplomacy in order to strengthen its positions in the region, to gain control over the neighboring countries; as well as to make its way towards the European Union. Being on the EU’s waiting list, Turkey strives to get advantages of its prolonged status as a candidate country

  7. A study of the multipolar composition of the electrofission cross section of 237Np

    International Nuclear Information System (INIS)

    The electrofission cross section for 237Np was measured over the energy range from 0,6 to 60,0 MeV. The multipolar composition of this cross section was investigated using the virtual photons formalism with three different techniques of analysis: unfolding and two versions of multiple parameter regression. (A.C.A.S.)

  8. Gold Nanobipyramid-Directed Growth of Length-Variable Silver Nanorods with Multipolar Plasmon Resonances.

    Science.gov (United States)

    Zhuo, Xiaolu; Zhu, Xingzhong; Li, Qian; Yang, Zhi; Wang, Jianfang

    2015-07-28

    We report on a method for the preparation of uniform and length-variable Ag nanorods through anisotropic Ag overgrowth on high-purity Au nanobipyramids. The rod diameters can be roughly tailored from ?20 nm to ?50 nm by judicious selection of differently sized Au nanobipyramids. The rod lengths can be tuned from ?150 nm to ?550 nm by varying the Ag precursor amount during the overgrowth process and/or by anisotropic shortening through mild oxidation. The controllable aspect ratios, high purity, and high dimensional uniformity of these Ag nanorods enable the observation of Fabry-Pérot-like multipolar plasmon resonance modes in the colloidal suspensions at the ensemble level, which has so far been demonstrated only on Au nanorods prepared electrochemically with anodic aluminum oxide templates. Depending on the mode order and geometry of the Ag nanorods, the multipolar plasmon wavelengths can be readily tailored over a wide spectral range from the visible to near-infrared region. We have further elucidated the relationships between the multipolar plasmon wavelengths and the geometric dimensions of the Ag nanorods at both the ensemble and single-particle levels. Our results indicate that the Au nanobipyramid-directed, dimensionally controllable Ag nanorods will be an attractive and promising candidate for developing multipolar plasmon-based devices and applications. PMID:26135608

  9. Early development of cortical brain responses in newborns and fetuses ? cognitive studies with fetal magnetoencephalography

    OpenAIRE

    Sheridan, Carolin

    2008-01-01

    During early developmental stages the brain is more vulnerable to physiological insult than the more mature brain. However, an early diagnosis of deficits might enhance the chances for successful interventions due to the high cortical plasticity of the immature brain. This thesis contains two studies on early cognitive development, conducted with a device called fetal magnetoencephalography (fMEG). It allows non-invasive recordings of cortical responses in utero. Objective: Two study para...

  10. Word repetition priming induced oscillations in auditory cortex: a magnetoencephalography study

    OpenAIRE

    Tavabi, Kambiz; Embick, David; Roberts, Timothy P.L.

    2011-01-01

    Magnetoencephalography was used in a passive repetition priming paradigm. Words in two frequency bins (high/low) were presented to subjects auditorily. Subjects’ brain responses to these stimuli were analyzed using synthetic aperture magnetometry. The main finding is that single word repetition of low frequency word pairs significantly attenuated the post-second word event related desynchronization in the theta-alpha (5–15Hz) bands, 200–600ms post second word stimulus onset. Peak significance...

  11. Oscillatory neuronal dynamics associated with manual acupuncture: a magnetoencephalography study using beamforming analysis

    OpenAIRE

    Asghar, Aziz U. R.; Johnson, Robyn L.; Woods, William; Green, Gary G.R.; Lewith, George; Macpherson, Hugh

    2012-01-01

    Magnetoencephalography (MEG) enables non-invasive recording of neuronal activity, with reconstruction methods providing estimates of underlying brain source locations and oscillatory dynamics from externally recorded neuromagnetic fields. The aim of our study was to use MEG to determine the effect of manual acupuncture on neuronal oscillatory dynamics. A major problem in MEG investigations of manual acupuncture is the absence of onset times for each needle manipulation. Given that beamforming...

  12. Temporal course of word recognition in skilled readers: A magnetoencephalography study

    OpenAIRE

    Simos, Panagiotis G.; Pugh, Kenneth; Mencl, Einar; Frost, Stephen; Fletcher, Jack M.; Sarkari, Shirin; Papanicolaou, Andrew C.

    2008-01-01

    The goal of the study was to investigate the neural circuit recruited by adult readers during performance of a lexical decision task by assessing the relative timing of neurophysiological activity in the brain regions that comprise this circuit. The time course of regional activation associated with lexical decision was studied in 17 adult volunteers using magnetoencephalography. Following activity in mesial occipital cortices, activation progressed to lateral and ventral occipito-temporal re...

  13. Spatiotemporal imaging of human brain activity using functional MRI constrained magnetoencephalography data: Monte Carlo simulations

    OpenAIRE

    Liu, Arthur K.; Belliveau, John W.; Dale, Anders M.

    1998-01-01

    The goal of our research is to develop an experimental and analytical framework for spatiotemporal imaging of human brain function. Preliminary studies suggest that noninvasive spatiotemporal maps of cerebral activity can be produced by combining the high spatial resolution (millimeters) of functional MRI (fMRI) with the high temporal resolution (milliseconds) of electroencephalography (EEG) and magnetoencephalography (MEG). Although MEG and EEG are sensitive to millisecond changes in mental ...

  14. Magnetar giant flares in multipolar magnetic fields. II. Flux rope eruptions with current sheets

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Lei [Key Laboratory for Research in Galaxies and Cosmology, Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030 (China); Yu, Cong, E-mail: muduri@shao.ac.cn, E-mail: cyu@ynao.ac.cn [Key Laboratory for the Structure and Evolution of Celestial Object, Chinese Academy of Sciences, Kunming 650011 (China)

    2014-11-20

    We propose a physical mechanism to explain giant flares and radio afterglows in terms of a magnetospheric model containing both a helically twisted flux rope and a current sheet (CS). With the appearance of a CS, we solve a mixed boundary value problem to get the magnetospheric field based on a domain decomposition method. We investigate properties of the equilibrium curve of the flux rope when the CS is present in background multipolar fields. In response to the variations at the magnetar surface, it quasi-statically evolves in stable equilibrium states. The loss of equilibrium occurs at a critical point and, beyond that point, it erupts catastrophically. New features show up when the CS is considered. In particular, we find two kinds of physical behaviors, i.e., catastrophic state transition and catastrophic escape. Magnetic energy would be released during state transitions. This released magnetic energy is sufficient to drive giant flares, and the flux rope would, therefore, go away from the magnetar quasi-statically, which is inconsistent with the radio afterglow. Fortunately, in the latter case, i.e., the catastrophic escape, the flux rope could escape the magnetar and go to infinity in a dynamical way. This is more consistent with radio afterglow observations of giant flares. We find that the minor radius of the flux rope has important implications for its eruption. Flux ropes with larger minor radii are more prone to erupt. We stress that the CS provides an ideal place for magnetic reconnection, which would further enhance the energy release during eruptions.

  15. Magnetar Giant Flares in Multipolar Magnetic Fields. II. Flux Rope Eruptions with Current Sheets

    Science.gov (United States)

    Huang, Lei; Yu, Cong

    2014-11-01

    We propose a physical mechanism to explain giant flares and radio afterglows in terms of a magnetospheric model containing both a helically twisted flux rope and a current sheet (CS). With the appearance of a CS, we solve a mixed boundary value problem to get the magnetospheric field based on a domain decomposition method. We investigate properties of the equilibrium curve of the flux rope when the CS is present in background multipolar fields. In response to the variations at the magnetar surface, it quasi-statically evolves in stable equilibrium states. The loss of equilibrium occurs at a critical point and, beyond that point, it erupts catastrophically. New features show up when the CS is considered. In particular, we find two kinds of physical behaviors, i.e., catastrophic state transition and catastrophic escape. Magnetic energy would be released during state transitions. This released magnetic energy is sufficient to drive giant flares, and the flux rope would, therefore, go away from the magnetar quasi-statically, which is inconsistent with the radio afterglow. Fortunately, in the latter case, i.e., the catastrophic escape, the flux rope could escape the magnetar and go to infinity in a dynamical way. This is more consistent with radio afterglow observations of giant flares. We find that the minor radius of the flux rope has important implications for its eruption. Flux ropes with larger minor radii are more prone to erupt. We stress that the CS provides an ideal place for magnetic reconnection, which would further enhance the energy release during eruptions.

  16. Polarization-dependent multipolar plasmon resonances in anisotropic multiscale au particles.

    Science.gov (United States)

    You, Eun-Ah; Zhou, Wei; Suh, Jae Yong; Huntington, Mark D; Odom, Teri W

    2012-02-28

    This paper reports the fabrication and characterization of three-dimensional (3D) multiscale Au particles with different aspect ratios. Increasing the length of the particles resulted in excitation of a longitudinal mode and two different transverse modes having different multipolar orders. The multipolar orders increased for both longitudinal and transverse modes as the aspect ratio increased. Finite-difference time-domain calculations revealed that the structural asymmetry of the 3D anisotropic particles were the reason for the two distinct transverse plasmon resonances. When the 3D structural change occurred at the ends of the multiscale particle, however, the optical response showed two resonances in the longitudinal direction and only a single resonance in the transverse direction. PMID:22276641

  17. The emerging multi-polar world and China's grand game

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Rajan [Los Alamos National Laboratory

    2011-01-19

    This talk outlines a scenario describing an emerging multipolar world that is aligned with geographical regions. The stability and security of this multipolar world is examined with respect to demographics, trade (economics), resource constraints, and development. In particular I focus on Asia which has two large countries, China and India, competing for resources and markets and examine the emerging regional relations, opportunities and threats. These relationships must overcome many hurdles - the Subcontinent is in a weak position politically and strategically and faces many threats, and China's growing power could help stabilize it or create new threats. Since the fate of 1.5 billion (2.4 billion by 2050) people depends on how the Subcontinent evolves, this talk is meant to initiates a discussion of what China and India can do to help the region develop and stabilize.

  18. Inhibition of multipolar plasmon excitation in periodic chains of gold nanoblocks.

    Science.gov (United States)

    Ueno, Kosei; Juodkazis, Saulius; Mizeikis, Vygantas; Ohnishi, Dai; Sasaki, Keiji; Misawa, Hiroaki

    2007-12-10

    Periodically corrugated chains of gold nanoblocks, fabricated with high precision by electron-beam lithography and lift-off techniques, were found to exhibit optical signatures of particle plasmon states in which relative contribution of longitudinal multipolar plasmons is significantly lower than that in equivalent rectangular gold nanorods. Plasmonic response of periodic chains is dominated by dipolar plasmon modes, which in the absence of multipolar exciations are seen as background-free and spectrally well-resolved extinction peaks at infrared (IR) wavelengths. This observation may help improve spectral parameters of IR plasmonic sub-wavelength antennae. Comparative studies of plasmon damping and dephasing in corrugated chains of nanoblocks and smooth rectangular nanorods are also presented. PMID:19550943

  19. Multipolar polarizabilities and two-body dispersion coefficients for Li by a variationally stable procedure

    International Nuclear Information System (INIS)

    Based on the ground-state wave function of Li obtained by Weakest Bound Electron (WBEPM) theory, the multipolar polarizabilities of Li and the two-body dispersion coefficients for the Li-Li system are calculated by utilizing the variationally stable procedure proposed by Gao and Starace. Evaluated values are in agreement with those previously reported, while the method is more simplified and easy to be extended to other alkali metal atoms. (authors)

  20. Deformations of multipolarity six at the saddle point of heaviest nuclei

    International Nuclear Information System (INIS)

    Saddle-point configuration of heaviest nuclei is studied in a multidimensional deformation space. Main attention is given to the role of the deformation of multipolarity six of a general type, described by four independent parameters. The dependence of the potential energy of a superheavy nucleus on these parameters at the saddle-point configuration is illustrated. The analysis is performed within a macroscopic-microscopic approach. (author)

  1. A New Configuration of Multipolar Cuff Electrode and Dedicated IC for Afferent Signal Recording

    OpenAIRE

    Bernard, Serge; Bertrand, Yves; Cathebras, Guy; Gouyet, Lionel; Guiraud, David

    2007-01-01

    Sensory information coming from natural sensors and being propagated on afferent nerve fibers could be used as feedback for a more efficient closed-loop control of a Functional Electrical Stimulation system. In order to extract and separate these signals according to their nerve fascicule origins, we propose a new architecture of a multipolar cuff electrode and an optimized integrated acquisition circuit. Concerning the electrode, we propose a specific configuration using a large number of po...

  2. POWER-SHIFTS IN THE GLOBAL ECONOMY. TRANSITION TOWARDS A MULTIPOLAR WORLD ORDER

    Directory of Open Access Journals (Sweden)

    Ion IGNAT

    2013-12-01

    Full Text Available The paper aims to analyze the new realities and trends related to the new polarity of the global economy, and thus the reconfiguration of global power centers, a process characterized by two simultaneous trends: the rise of new powers and the relative decline of traditional powers. At the beginning of 21st century, global power is suffering two major changes: on the one hand it manifests a transition from West to East, from Atlantic to the Asia-Pacific, and on the other hand, a diffusion from state to non-state actors. Current global economic power has a multipolar distribution, shared between the United States, European Union, Japan and BRICs, with no balance of power between these poles, opposed by the strong ambition of rising countries, China especially, China that rivals the traditional powers represented by the developed countries. The evolution of the main macroeconomic indicators given by the most important global organizations, shows a gradual transition towards a multipolar world. Therefore, the United States is and will remain for a long period of time the global economic leader. However, as China, India and Brazil are growing rapidly, and Russia is looking for lost status, the world is becoming multipolar.

  3. Image-guided multipolar radiofrequency ablation of liver tumours: initial clinical results

    International Nuclear Information System (INIS)

    The local effectiveness and clinical usefulness of multipolar radiofrequency (RF) ablation of liver tumours was evaluated. Sixty-eight image-guided RF sessions were performed using a multipolar device with bipolar electrodes in 53 patients. There were 45 hepatocellular carcinomas (HCC) and 42 metastases with a diameter ?3 cm (n = 55), 3.1-5 cm (n = 29) and >5 cm (n = 3); 26 nodules were within 5 mm from large vessels. Local effectiveness and complications were evaluated after RF procedures. Mean follow-up was 17 ± 10 months. Recurrence and survival rates were analysed by the Kaplan-Meier method. The primary and secondary technical effectiveness rate was 82% and 95%, respectively. The major and minor complication rate was 2.9%, respectively. The local tumour progression at 1- and 2-years was 5% and 9% for HCC nodules and 17% and 31% for metastases, respectively; four of 26 nodules (15%) close to vessels showed local progression. The survival at 1 year and 2 years was 97% and 90% for HCC and 84% and 68% for metastases, respectively. Multipolar RF technique creates ablation zones of adequate size and tailored shape and is effective to treat most liver tumours, including those close to major hepatic vessels. (orig.)

  4. Magnetoencephalography - a noninvasive brain imaging method with 1 ms time resolution

    International Nuclear Information System (INIS)

    The basics of magnetoencephalography (MEG), i.e. the measurement and the analysis of the tiny magnetic fields generated outside the scalp by the working human brain, are reviewed. Three main topics are discussed: (1) the relationship between the magnetic field and its generators, including on one hand the neurophysiological basis and the physical theory of magnetic field generation, and on the other hand the techniques for the estimation of the sources from the magnetic field measurements; (2) the instrumental techniques and the laboratory practice of neuromagnetic field measurement and (3) the main applications of MEG in basic neurophysiology as well as in clinical neurology. (author)

  5. Magnetoencephalography demonstrates multiple asynchronous generators during human sleep spindles.

    Science.gov (United States)

    Dehghani, Nima; Cash, Sydney S; Rossetti, Andrea O; Chen, Chih Chuan; Halgren, Eric

    2010-07-01

    Sleep spindles are approximately 1 s bursts of 10-16 Hz activity that occur during stage 2 sleep. Spindles are highly synchronous across the cortex and thalamus in animals, and across the scalp in humans, implying correspondingly widespread and synchronized cortical generators. However, prior studies have noted occasional dissociations of the magnetoencephalogram (MEG) from the EEG during spindles, although detailed studies of this phenomenon have been lacking. We systematically compared high-density MEG and EEG recordings during naturally occurring spindles in healthy humans. As expected, EEG was highly coherent across the scalp, with consistent topography across spindles. In contrast, the simultaneously recorded MEG was not synchronous, but varied strongly in amplitude and phase across locations and spindles. Overall, average coherence between pairs of EEG sensors was approximately 0.7, whereas MEG coherence was approximately 0.3 during spindles. Whereas 2 principle components explained approximately 50% of EEG spindle variance, >15 were required for MEG. Each PCA component for MEG typically involved several widely distributed locations, which were relatively coherent with each other. These results show that, in contrast to current models based on animal experiments, multiple asynchronous neural generators are active during normal human sleep spindles and are visible to MEG. It is possible that these multiple sources may overlap sufficiently in different EEG sensors to appear synchronous. Alternatively, EEG recordings may reflect diffusely distributed synchronous generators that are less visible to MEG. An intriguing possibility is that MEG preferentially records from the focal core thalamocortical system during spindles, and EEG from the distributed matrix system. PMID:20427615

  6. Resting-state magnetoencephalography study of “small world” characteristics and cognitive dysfunction in patients with glioma

    Directory of Open Access Journals (Sweden)

    Hu X

    2013-04-01

    Full Text Available Xin-Hua Hu, Ting Lei, Hua-Zhong Xu, Yuan-Jie Zou, Hong-Yi Liu Department of Neurosurgery, Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People's Republic of China Background: The purpose of this study was to analyze “small world” characteristics in glioma patients in order to understand the relationship between cognitive dysfunction and brain functional connectivity network in the resting state. Methods: Resting-state magnetoencephalography was performed in 20 patients with glioma and 20 healthy subjects. The clustering coefficient of the resting functional connectivity network in the brain, average path length, and “small world” index (SWI were calculated. Cognitive function was estimated by testing of attention, verbal fluency, memory, athletic ability, visual-spatial ability, and intelligence. Results: Compared with healthy controls, patients with glioma showed decreased cognitive function, and diminished low and high gamma band “small world” characteristics in the resting functional connectivity network. Conclusion: The SWI is associated with cognitive function and is diminished in patients with glioma, and is therefore correlated with cognition dysfunction. Keywords: glioma, cognitive dysfunction, “small world”, functional connectivity network, magnetoencephalography

  7. Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes.

    Science.gov (United States)

    Pollock, Jonathan; Borkin, Dmitry; Lund, George; Purohit, Trupta; Dyguda-Kazimierowicz, Edyta; Grembecka, Jolanta; Cierpicki, Tomasz

    2015-09-24

    Multipolar interactions involving fluorine and the protein backbone have been frequently observed in protein-ligand complexes. Such fluorine-backbone interactions may substantially contribute to the high affinity of small molecule inhibitors. Here we found that introduction of trifluoromethyl groups into two different sites in the thienopyrimidine class of menin-MLL inhibitors considerably improved their inhibitory activity. In both cases, trifluoromethyl groups are engaged in short interactions with the backbone of menin. In order to understand the effect of fluorine, we synthesized a series of analogues by systematically changing the number of fluorine atoms, and we determined high-resolution crystal structures of the complexes with menin. We found that introduction of fluorine at favorable geometry for interactions with backbone carbonyls may improve the activity of menin-MLL inhibitors as much as 5- to 10-fold. In order to facilitate the design of multipolar fluorine-backbone interactions in protein-ligand complexes, we developed a computational algorithm named FMAP, which calculates fluorophilic sites in proximity to the protein backbone. We demonstrated that FMAP could be used to rationalize improvement in the activity of known protein inhibitors upon introduction of fluorine. Furthermore, FMAP may also represent a valuable tool for designing new fluorine substitutions and support ligand optimization in drug discovery projects. Analysis of the menin-MLL inhibitor complexes revealed that the backbone in secondary structures is particularly accessible to the interactions with fluorine. Considering that secondary structure elements are frequently exposed at protein interfaces, we postulate that multipolar fluorine-backbone interactions may represent a particularly attractive approach to improve inhibitors of protein-protein interactions. PMID:26288158

  8. Early visual processing is affected by clinical subtype in patients with unilateral spatial neglect: A magnetoencephalography study.

    Directory of Open Access Journals (Sweden)

    Katsuhiro Mizuno

    2013-07-01

    CONCLUSIONS: These results demonstrate that early VEFs are disrupted in patients with unilateral spatial neglect and support the concept that deficits in visual processing differ according to the clinical subtype of unilateral spatial neglect and the lesion location. This study also demonstrates the feasibility of using magnetoencephalography to explore subtypes of neglect.

  9. Pathological documentation of complete elimination of Barrett's metaplasia following endoscopic multipolar electrocoagulation therapy

    Science.gov (United States)

    Fennerty, M; Corless, C; Sheppard, B; Faigel, D; Lieberman, D; Sampliner, R

    2001-01-01

    The previous paradigm that Barrett's is an irreversible premalignant lesion has recently been challenged by a proliferation of reports documenting elimination of Barrett's by a variety of endoscopic techniques. Whether Barrett's is entirely eliminated is unknown as endoscopic biopsy samples the surface of the epithelium only. Numerous reports document underlying specialised columnar epithelium in many of these trials. Until now there have been no reports of pathological examination of the entire oesophagus as a specimen. This case documents complete elimination of intestinal metaplasia from the oesophagus and supports the biological plausibility of these research techniques.


Keywords: Barrett's oesophagus; endoscopy; multipolar electrocoagulation PMID:11413122

  10. Multipolar third-harmonic generation driven by optically-induced magnetic resonances

    CERN Document Server

    Smirnova, Daria A; Smirnov, Lev A; Kivshar, Yuri S

    2016-01-01

    We analyze the third-harmonic generation from high-index dielectric nanoparticles and discuss the basic features and multipolar nature of the parametrically generated electromagnetic fields near the Mie-type optical resonances in silicon particles. By combining both analytical and numerical methods, we study the nonlinear scattering from simple nanoparticle geometries such as spheres and disks driven by the magnetic dipole resonance. We reveal the approaches for manipulating and directing the resonantly enhanced nonlinear emission with subwavelength all-dielectric structures that can be of a particular interest for a design of nonlinear optical antennas and engineering the magnetic optical nonlinear response at nanoscale.

  11. Denoising and Frequency Analysis of Noninvasive Magnetoencephalography Sensor Signals for Functional Brain Mapping

    CERN Document Server

    Ukil, A

    2015-01-01

    Magnetoencephalography (MEG) is an important noninvasive, nonhazardous technology for functional brain mapping, measuring the magnetic fields due to the intracellular neuronal current flow in the brain. However, most often, the inherent level of noise in the MEG sensor data collection process is large enough to obscure the signal(s) of interest. In this paper, a denoising technique based on the wavelet transform and the multiresolution signal decomposition technique along with thresholding is presented, substantiated by application results. Thereafter, different frequency analysis are performed on the denoised MEG signals to identify the major frequencies of the brain oscillations present in the denoised signals. Time-frequency plots (spectrograms) of the denoised signals are also provided.

  12. Epistemics for Learning Disabilities: Contributions from Magnetoencephalography, a Functional Neuroimaging Tool

    Directory of Open Access Journals (Sweden)

    VÍCTOR SANTIUSTE-BERMEJO

    2008-01-01

    Full Text Available The syndrome known as Learning Disabilities (LD was described by S. Kirk in 1963. From that point on, institutions from the US, Canada and Spain have engaged in refining the concept and classification of LDs. The Complutense University in Spain, has proposed a descriptive and all-embracing definition, and has studied the different manifestations of LD, pursuing the description of biological markers and neurological features of LD’s main expressions: dyslexia, dyscalculia, dysorthographia, Attention Deficit and Hyperactivity Disorder –ADHD, and so forth. Findings in LD using functional neuroimaging techniques, namely Magnetoencephalography (MEG, are described. MEG is a non-invasive technique, which records magnetic fields naturally generated by the brain and their spatial distribution. It allows simultaneous functional and structural information. MEG is therefore used in the study of primary and superior cognitive functions, in surveillance of patterns of normal cognitive function and those specific to the different LD clinical manifestations.

  13. Role of the multipolar black-body radiation shifts in the atomic clocks at the 10-18 uncertainty level

    Indian Academy of Sciences (India)

    B K Sahoo

    2014-08-01

    We present here an overview of the role of the multipolar black-body radiation (BBR) shifts in the single ion atomic clocks to appraise the anticipated 10-18 uncertainty level. With an attempt to use the advanced technologies for reducing the instrumental uncertainties at the unprecedented low, it is essential to investigate contributions from the higher-order systematics to achieve the ambitious goal of securing the most precise clock frequency standard. In this context, we have analysed contributions to the BBR shifts from the multipolar polarizabilities in a few ion clocks.

  14. Multipolarization SAR data for surface feature delineation and forest vegetation characterization

    Science.gov (United States)

    Wu, Shih-Tseng; Sader, Steven A.

    1987-01-01

    This paper presents the utility of multipolarization Synthetic Aperture Radar (SAR) data for surface feature delineation and forest vegetation characterization. Three channels of radioed data (VV/HH, VH/HH, and VH/VV) are generated from the HH, VV, and VH polarization data (V = vertical, H = horizontal). The radioed data are linearly stretched to yield a digital number within a range of 0 to 255. The techniques for reducing SAR speckle noise and for measuring the degree of separation are discussed. For surface feature delineation, the results indicate that cross polarization as well as cross polarization radioed data better delineate those surface features that are difficult to separate by like polarization data. The results suggest using a median value filtering technique to reduce within-plot data fluctuation to increase the separability measure. For forest vegetation characterization, the results indicate that multipolarization SAR data may be used to estimate forest properties such as total-tree biomass, basal area, and tree height.

  15. Multipolar hepatic radiofrequency ablation using up to six applicators: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Bruners, P.; Schmitz-Rode, T. [RWTH Aachen (Germany). Lehrstuhl fuer Angewandte Medizintechnik; Guenther, R.W.; Mahnken, A. [Universitaetsklinikum RWTH Aachen (Germany). Klinik fuer Radiologische Diagnostik

    2008-03-15

    Purpose: to evaluate the clinical feasibility and safety of hepatic radiofrequency (RF) ablation using a multipolar RF system permitting the simultaneous use of up to six electrodes. Materials and methods: ten patients (3 female, 7 male, mean age 61) suffering from 29 hepatic metastases (range: 1-5) of different tumors were treated with a modified multipolar RF system (CelonLab Power, Celon Medical Instruments, Teltow, Germany) operating four to six needle-shaped internally cooled RF applicators. The procedure duration, applied energy and generator output were recorded during the intervention. The treatment result and procedure-related complications were analyzed. The achieved coagulation volume was calculated on the basis of contrast-enhanced CT scans 24 hours after RF ablation. Results: complete tumor ablation was achieved in all cases as determined by the post-interventional lack of contrast enhancement in the target region using four applicators in five patients, five applicators in one patient and six applicators in four patients. A mean energy deposition of 353.9 {+-} 176.2 kJ resulted in a mean coagulation volume of 115.9 {+-} 79.5 cm{sup 3}. The mean procedure duration was 74.9 {+-} 21.2 minutes. Four patients showed an intraabdominal hemorrhage which necessitated further interventional treatment (embolization; percutaneous histoacryl injection) in two patients. (orig.)

  16. Multipolar hepatic radiofrequency ablation using up to six applicators: preliminary results

    International Nuclear Information System (INIS)

    Purpose: to evaluate the clinical feasibility and safety of hepatic radiofrequency (RF) ablation using a multipolar RF system permitting the simultaneous use of up to six electrodes. Materials and methods: ten patients (3 female, 7 male, mean age 61) suffering from 29 hepatic metastases (range: 1-5) of different tumors were treated with a modified multipolar RF system (CelonLab Power, Celon Medical Instruments, Teltow, Germany) operating four to six needle-shaped internally cooled RF applicators. The procedure duration, applied energy and generator output were recorded during the intervention. The treatment result and procedure-related complications were analyzed. The achieved coagulation volume was calculated on the basis of contrast-enhanced CT scans 24 hours after RF ablation. Results: complete tumor ablation was achieved in all cases as determined by the post-interventional lack of contrast enhancement in the target region using four applicators in five patients, five applicators in one patient and six applicators in four patients. A mean energy deposition of 353.9 ± 176.2 kJ resulted in a mean coagulation volume of 115.9 ± 79.5 cm3. The mean procedure duration was 74.9 ± 21.2 minutes. Four patients showed an intraabdominal hemorrhage which necessitated further interventional treatment (embolization; percutaneous histoacryl injection) in two patients. (orig.)

  17. An analysis of the electromagnetic field in multi-polar linear induction system

    International Nuclear Information System (INIS)

    In this paper a new method for determination of the electromagnetic field vectors in a multi-polar linear induction system (LIS) is described. The analysis of the electromagnetic field has been done by four dimensional electromagnetic potentials in conjunction with theory of the magnetic loops . The electromagnetic field vectors are determined in the Minkovski's space as elements of the Maxwell's tensor. The results obtained are compared with those got from the analysis made by the finite elements method (FEM).With the method represented in this paper one can determine the electromagnetic field vectors in the multi-polar linear induction system using four-dimensional potential. A priority of this method is the obtaining of analytical results for the electromagnetic field vectors. These results are also valid for linear media. The dependencies are valid also at high speeds of movement. The results of the investigated linear induction system are comparable to those got by the finite elements method. The investigations may be continued in the determination of other characteristics such as drag force, levitation force, etc. The method proposed in this paper for an analysis of linear induction system can be used for optimization calculations. (Author)

  18. Multi-polar resistance switching and memory effect in copper phthalocyanine junctions

    International Nuclear Information System (INIS)

    Copper phthalocyanine junctions, fabricated by magnetron sputtering and evaporating methods, show multi-polar (unipolar and bipolar) resistance switching and the memory effect. The multi-polar resistance switching has not been observed simultaneously in one organic material before. With both electrodes being cobalt, the unipolar resistance switching is universal. The high resistance state is switched to the low resistance state when the bias reaches the set voltage. Generally, the set voltage increases with the thickness of copper phthalocyanine and decreases with increasing dwell time of bias. Moreover, the low resistance state could be switched to the high resistance state by absorbing the phonon energy. The stability of the low resistance state could be tuned by different electrodes. In Au/copper phthalocyanine/Co system, the low resistance state is far more stable, and the bipolar resistance switching is found. Temperature dependence of electrical transport measurements demonstrates that there are no obvious differences in the electrical transport mechanism before and after the resistance switching. They fit quite well with Mott variable range hopping theory. The effect of Al2O3 on the resistance switching is excluded by control experiments. The holes trapping and detrapping in copper phthalocyanine layer are responsible for the resistance switching, and the interfacial effect between electrodes and copper phthalocyanine layer affects the memory effect. (interdisciplinary physics and related areas of science and technology)

  19. Multipolar electromagnetic fields around neutron stars: exact vacuum solutions and related properties

    CERN Document Server

    Petri, Jerome

    2015-01-01

    The magnetic field topology in the surrounding of neutron stars is one of the key questions in pulsar magnetospheric physics. A very extensive literature exists about the assumption of a dipolar magnetic field but very little progress has been made in attempts to include multipolar components in a self-consistent way. In this paper, we study the effect of multipolar electromagnetic fields anchored in the star. We give exact analytical solutions in closed form for any order $l$ and apply them to the retarded point quadrupole ($l=2$), hexapole ($l=3$) and octopole ($l=4$), a generalization of the retarded point dipole ($l=1$). We also compare the Poynting flux from each multipole and show that the spin down luminosity depends on the ratio $R/r_{\\rm L}$, $R$ being the neutron star radius and $r_{\\rm L}$ the light-cylinder radius. Therefore the braking index also depends on $R/r_{\\rm L}$. As such multipole fields possess very different topology, most importantly smaller length scales compared to the dipolar field...

  20. Distributed Multipolar Expansion Approach to Calculation of Excitation Energy Transfer Couplings.

    Science.gov (United States)

    B?asiak, Bartosz; Maj, Micha?; Cho, Minhaeng; Góra, Robert W

    2015-07-14

    We propose a new approach for estimating the electrostatic part of the excitation energy transfer (EET) coupling between electronically excited chromophores based on the transition density-derived cumulative atomic multipole moments (TrCAMM). In this approach, the transition potential of a chromophore is expressed in terms of truncated distributed multipolar expansion and analytical formulas for the TrCAMMs are derived. The accuracy and computational feasibility of the proposed approach is tested against the exact Coulombic couplings, and various multipole expansion truncation schemes are analyzed. The results of preliminary calculations show that the TrCAMM approach is capable of reproducing the exact Coulombic EET couplings accurately and efficiently and is superior to other widely used schemes: the transition charges from electrostatic potential (TrESP) and the transition density cube (TDC) method. PMID:26575762

  1. Dual-symmetric Lagrangians in quantum electrodynamics: I. Conservation laws and multi-polar coupling

    Energy Technology Data Exchange (ETDEWEB)

    Drummond, Peter D [ARC Center of Excellence for Quantum-Atom Optics, School of Physical Sciences, The University of Queensland, Brisbane, Qld 4072 (Australia)

    2006-08-14

    By using a complex field with a symmetric combination of electric and magnetic fields, a first-order covariant Lagrangian for Maxwell's equations is obtained, similar to the Lagrangian for the Dirac equation. This leads to a dual-symmetric quantum electrodynamic theory with an infinite set of local conservation laws. The dual symmetry is shown to correspond to a helical phase, conjugate to the conserved helicity. There is also a scaling symmetry, conjugate to the conserved entanglement. The results include a novel form of the photonic wavefunction, with a well-defined helicity number operator conjugate to the chiral phase, related to the fundamental dual symmetry. Interactions with charged particles can also be included. Transformations from minimal coupling to multi-polar or more general forms of coupling are particularly straightforward using this technique. The dual-symmetric version of quantum electrodynamics derived here has potential applications to nonlinear quantum optics and cavity quantum electrodynamics.

  2. Plasma diffusion through a two-dimensional magnetic field. Application to multipolar discharge

    International Nuclear Information System (INIS)

    In this work, a collisional plasma diffusion theory through a two dimensional magnetic field is presented. This study allows to define two types of diffusion domains: the weak field domain, where diffusion is practically isotropic, and strong field domain where diffusion is only parallel to field lines. The inversion and ion confinement by ambipolar electric field, perpendicular to line fields, is also understood. This theory is applied to a multipolar discharge. A sheath thickness can be defined, which is the width of the region in which the plasma diffusion is limited by the magnetic field. Little dependence with magnetic field is found. All these results have been observed experimentally. The diffusion equation numerical solution allows to find the density and potential profiles. The comparison of the density in the middle of the plasma with and without multicusp field is done

  3. Localization of Interictal Epileptiform Activity Using Magnetoencephalography with Synthetic Aperture Magnetometry in Patients with a Vagus Nerve Stimulator

    OpenAIRE

    Stapleton-Kotloski, Jennifer R.; Kotloski, Robert J.; Boggs, Jane A.; Popli, Gautam; O’Donovan, Cormac A.; Couture, Daniel E.; Cornell, Cassandra; Godwin, Dwayne W.

    2014-01-01

    Magnetoencephalography (MEG) provides useful and non-redundant information in the evaluation of patients with epilepsy, and in particular, during the pre-surgical evaluation of pharmaco-resistant epilepsy. Vagus nerve stimulation (VNS) is a common treatment for pharmaco-resistant epilepsy. However, interpretation of MEG recordings from patients with a VNS is challenging due to the severe magnetic artifacts produced by the VNS. We used synthetic aperture magnetometry (g2) [SAM(g2)], an adaptiv...

  4. Characterizing global statistical significance of spatiotemporal hot spots in magnetoencephalography/electroencephalography source space via excursion algorithms

    OpenAIRE

    Xu, Yang; Gustavo P Sudre; Wang, Wei; Douglas J. Weber; Kass, Robert E.

    2011-01-01

    Identifying brain regions with high differential response under multiple experimental conditions is a fundamental goal of functional imaging. In many studies, regions of interest (ROIs) are not determined a priori but are instead discovered from the data, a process that requires care because of the great potential for false discovery. An additional challenge is that magnetoencephalography/electroencephalography sensor signals are very noisy, and brain source images are usually produced by ave...

  5. Magnetoencefalografía: mapeo de la dinámica espaciotemporal de la actividad neuronal / Magnetoencephalography: mapping the spatiotemporal dynamics of neuronal activity

    Scientific Electronic Library Online (English)

    Yang, Zhang; Wenbo, Zhang; Vicenta, Reynoso Alcántara; Juan, Silva-Pereyra.

    2014-01-01

    Full Text Available La magnetoencefalografía es una técnica de neuroimagen no invasiva que mide, con gran exactitud temporal, los campos magnéticos en la superficie de la cabeza producidos por corrientes neuronales en regiones cerebrales. Esta técnica es sumamente útil en la investigación básica y clínica, porque ademá [...] s permite ubicar el origen de la actividad neural en el cerebro. En esta revisión se abordan aspectos básicos de la biofísica del método y se discuten los hallazgos sobre procesos como la percepción del habla, la atención auditiva y la integración de la información visual y auditiva, que son importantes en la investigación. Igualmente, se ilustran sus ventajas, sus limitaciones y las nuevas tendencias en la investigación con magnetoencefalografía. Abstract in english Magnetoencephalography is a noninvasive imaging technique that measures the magnetic fields on the surface of the head --produced by neuronal currents in brain regions -- and provides highly accurate temporal information. Magnetoencephalography is extremely useful in basic and clinical research as i [...] t can also locate the sources of neural activity in the brain. This review chiefly approaches biophysics-related aspects of the method; findings are also discussed on issues such as speech perception, auditory attention and integration of visual-auditory information, which are quintessential in this type of research. Lastly, this review discusses the benefits and limitations of magnetoencephalography and outlines new trends in research with this technique.

  6. The neural processing of musical instrument size information in the brain investigated by magnetoencephalography

    Science.gov (United States)

    Rupp, Andre; van Dinther, Ralph; Patterson, Roy D.

    2005-04-01

    The specific cortical representation of size was investigated by recording auditory evoked fields (AEFs) elicited by changes of instrument size and pitch. In Experiment 1, a French horn and one scaled to double the size played a three note melody around F3 or its octave, F4. Many copies of these four melodies were played in random order and the AEF was measured continuously. A similar procedure was applied to saxophone sounds in a separate run. In Experiment 2, the size and type of instrument (French horn and saxophone) were varied without changing the octave. AEFs were recorded in five subjects using magnetoencephalography and evaluated by spatio-temporal source analysis with one equivalent dipole in each hemisphere. The morphology of the source waveforms revealed that each note within the melody elicits a well-defined P1-N1-P2 AEF-complex with adaptation for the 2nd and 3rd note. At the transition of size, pitch, or both, a larger AEF-complex was evoked. However, size changes elicited a stronger N1 than pitch changes. Furthermore, this size-related N1 enhancement was larger for French horn than saxophone. The results indicate that the N1 plays an important role in the specific representation of instrument size.

  7. Examining Neural Synchrony in Autism During Resting State With Magnetoencephalography (MEG

    Directory of Open Access Journals (Sweden)

    Smith Tyronda D.

    2014-09-01

    Full Text Available Autism Spectrum Disorder (ASD comprises a group of neurodevelopmental disorders associated with the functioning of the central nervous system (American Psychiatric Association, 2013. The symptoms experienced by individuals with this disorder include social impairment, communication difficulties, and repetitive and stereotyped behaviors. The etiology of ASD has yet to be determined, and it is typically diagnosed based on behavioral criteria of the Diagnostic and Statistical Manual- 5th Edition (DSM-5; APA, 2013 and confirmed with “gold standard” assessment tools such as the Autism Diagnostic Observation Schedule (ADOS and Autism Diagnostic Interview- Revised (ADI-R; Johnson Center for Child Health Development, 2014. Abnormalities in synchronous neural activity have been hypothesized to be a core pathophysiological mechanism (Cornew et al., 2012. Magnetoencephalography (MEG can measure synchronous neural activity during resting state, when the brain is not consciously engaged in cognitive processing. Coherence is a measure of the synchronicity. We examined differences in coherence during resting state in ASD, compared to neurotypical developing individuals (NT, in an attempt to identify potential biomarkers and illuminate a core etiological mechanism.

  8. Differential spectral power alteration following acupuncture at different designated places revealed by magnetoencephalography

    Science.gov (United States)

    You, Youbo; Bai, Lijun; Dai, Ruwei; Xue, Ting; Zhong, Chongguang; Liu, Zhenyu; Wang, Hu; Feng, Yuanyuan; Wei, Wenjuan; Tian, Jie

    2012-03-01

    As an ancient therapeutic technique in Traditional Chinese Medicine, acupuncture has been used increasingly in modern society to treat a range of clinical conditions as an alternative and complementary therapy. However, acupoint specificity, lying at the core of acupuncture, still faces many controversies. Considering previous neuroimaging studies on acupuncture have mainly employed functional magnetic resonance imaging, which only measures the secondary effect of neural activity on cerebral metabolism and hemodynamics, in the current study, we adopted an electrophysiological measurement technique named magnetoencephalography (MEG) to measure the direct neural activity. 28 healthy college students were recruited in this study. We filtered MEG data into 5 consecutive frequency bands (delta, theta, alpha, beta and gamma band) and grouped 140 sensors into 10 main brain regions (left/right frontal, central, temporal, parietal and occipital regions). Fast Fourier Transformation (FFT) based spectral analysis approach was further performed to explore the differential band-limited power change patterns of acupuncture at Stomach Meridian 36 (ST36) using a nearby nonacupoint (NAP) as control condition. Significantly increased delta power and decreased alpha as well as beta power in bilateral frontal ROIs were observed following stimulation at ST36. Compared with ST36, decreased alpha power in left and right central, right parietal as well as right temporal ROIs were detected in NAP group. Our research results may provide additional evidence for acupoint specificity.

  9. Development of human somatosensory cortical functions – what have we learned from magnetoencephalography: A review

    Directory of Open Access Journals (Sweden)

    Päivi Nevalainen

    2014-03-01

    Full Text Available The mysteries of early development of cortical processing in humans have started to unravel with the help of new noninvasive brain research tools like multichannel magnetoencephalography (MEG. In this review, we evaluate, within a wider neuroscientific and clinical context, the value of MEG in studying normal and disturbed functional development of the human somatosensory system. The combination of excellent temporal resolution and good localization accuracy provided by MEG has, in the case of somatosensory studies, enabled the differentiation of activation patterns from the newborn’s primary (SI and secondary somatosensory (SII areas. Furthermore, MEG has shown that the functioning of both SI and SII in newborns has particular immature features in comparison with adults. In extremely preterm infants, the neonatal MEG response from SII also seems to potentially predict developmental outcome: those lacking SII responses at term show worse motor performance at age two years than those with normal SII responses at term. In older children with unilateral early brain lesions, bilateral alterations in somatosensory cortical activation detected in MEG imply that the impact of a localized insult may have an unexpectedly wide effect on cortical somatosensory networks. The achievements over the last decade show that MEG provides a unique approach for studying the development of the somatosensory system and its disturbances in childhood. MEG well complements other neuroimaging methods in studies of cortical processes in the developing brain.

  10. Development of Human Somatosensory Cortical Functions - What have We Learned from Magnetoencephalography: A Review.

    Science.gov (United States)

    Nevalainen, Päivi; Lauronen, Leena; Pihko, Elina

    2014-01-01

    The mysteries of early development of cortical processing in humans have started to unravel with the help of new non-invasive brain research tools like multichannel magnetoencephalography (MEG). In this review, we evaluate, within a wider neuroscientific and clinical context, the value of MEG in studying normal and disturbed functional development of the human somatosensory system. The combination of excellent temporal resolution and good localization accuracy provided by MEG has, in the case of somatosensory studies, enabled the differentiation of activation patterns from the newborn's primary (SI) and secondary somatosensory (SII) areas. Furthermore, MEG has shown that the functioning of both SI and SII in newborns has particular immature features in comparison with adults. In extremely preterm infants, the neonatal MEG response from SII also seems to potentially predict developmental outcome: those lacking SII responses at term show worse motor performance at age 2?years than those with normal SII responses at term. In older children with unilateral early brain lesions, bilateral alterations in somatosensory cortical activation detected in MEG imply that the impact of a localized insult may have an unexpectedly wide effect on cortical somatosensory networks. The achievements over the last decade show that MEG provides a unique approach for studying the development of the somatosensory system and its disturbances in childhood. MEG well complements other neuroimaging methods in studies of cortical processes in the developing brain. PMID:24672468

  11. Development of Human Somatosensory Cortical Functions – What have We Learned from Magnetoencephalography: A Review

    Science.gov (United States)

    Nevalainen, Päivi; Lauronen, Leena; Pihko, Elina

    2014-01-01

    The mysteries of early development of cortical processing in humans have started to unravel with the help of new non-invasive brain research tools like multichannel magnetoencephalography (MEG). In this review, we evaluate, within a wider neuroscientific and clinical context, the value of MEG in studying normal and disturbed functional development of the human somatosensory system. The combination of excellent temporal resolution and good localization accuracy provided by MEG has, in the case of somatosensory studies, enabled the differentiation of activation patterns from the newborn’s primary (SI) and secondary somatosensory (SII) areas. Furthermore, MEG has shown that the functioning of both SI and SII in newborns has particular immature features in comparison with adults. In extremely preterm infants, the neonatal MEG response from SII also seems to potentially predict developmental outcome: those lacking SII responses at term show worse motor performance at age 2?years than those with normal SII responses at term. In older children with unilateral early brain lesions, bilateral alterations in somatosensory cortical activation detected in MEG imply that the impact of a localized insult may have an unexpectedly wide effect on cortical somatosensory networks. The achievements over the last decade show that MEG provides a unique approach for studying the development of the somatosensory system and its disturbances in childhood. MEG well complements other neuroimaging methods in studies of cortical processes in the developing brain. PMID:24672468

  12. Magnetoencephalography Detection of High-Frequency Oscillations in the Developing Brain

    Directory of Open Access Journals (Sweden)

    Jing Xiang

    2014-12-01

    Full Text Available Increasing evidence from invasive intracranial recordings suggests that the matured brain generates both physiological and pathological high-frequency signals. The present study was designed to detect high-frequency brain signals in the developing brain using newly developed magnetoencephalography (MEG methods. Twenty healthy children were studied with a high sampling rate MEG system. Functional high-frequency brain signals were evoked by electrical stimulation applied to the index fingers. To determine if the high-frequency neuromagnetic signals are true brain responses in high-frequency range, we analyzed the MEG data using the conventional averaging as well as newly developed time-frequency analysis along with beamforming. The data of healthy children showed that very high-frequency brain signals (> 1000 Hz in the somatosensory cortex in the developing brain could be detected and localized using MEG. The amplitude of very high-frequency brain signals was significantly weaker than that of the low-frequency brain signals. Very high-frequency brain signals showed a much earlier latency than those of a low-frequency. Magnetic source imaging (MSI revealed that a portion of the high-frequency signals was from the somatosensory cortex, another portion of the high-frequency signals was probably from the thalamus. Our results provide evidence that the developing brain generates high-frequency signals that can be detected with the noninvasive technique of MEG. MEG detection of high-frequency brain signals may open a new window for the study of developing brain function.

  13. First results for a superconducting imaging-surface sensor array for magnetoencephalography

    Energy Technology Data Exchange (ETDEWEB)

    Kraus, R.H. Jr.; Flynn, E.R.; Overton, W.; Espy, M.A.; George, J.S.; Matlachov, A.; Peters, M.V.; Ruminer, P.

    1998-12-31

    Magnetoencephalography (MEG) follows from the initial fundamental work of Cohen in 1968 and development by several groups, most notably at MIT and at NYU, based on the development of the Superconducting QUantum Interference Device (SQUID) using the Josephson effect. The SQUID`s incredible sensitivity to magnetic fields permits the measurement of the very weak magnetic fields emitted from the human brain due to intracellular neuronal currents. Current growth in MEG is dominated by multiple sensor arrays covering much of the head. These new large devices have primarily been developed and made commercially available by several companies including BTI in the US, CTF in Canada, and Neuromag in Finland. Large projects are also in place in Japan. These systems contain more than 100 sensors spaced at various intervals over the head using various configurations of magnetometers and gradiometers. The different designs available on the market are driven by factors such as detection efficiency, cost, and application. They now present a completely novel whole-head SQUID array system using a superconducting imaging-surface gradiometer concept derived at Los Alamos. Preliminary tests have demonstrated higher performance, lower noise, and additional shielding of background fields while using simpler fabrication techniques than existing whole-head MEG systems, which should reduce production costs.

  14. Magnetoencephalography based on high-Tc superconductivity: a closer look into the brain?

    CERN Document Server

    Öisjöen, F; Figueras, G A; Chukharkin, M L; Kalabukhov, A; Hedström, A; Elam, M; Winkler, D

    2011-01-01

    Magnetoencephalography (MEG) enables the study of brain activity by recording the magnetic fields generated by neural currents and has become an important technique for neuroscientists in research and clinical settings. Unlike the liquid-helium cooled low-Tc superconducting quantum interference devices (SQUIDs) that have been at the heart of modern MEG systems since their invention, high-Tc SQUIDs can operate with liquid nitrogen cooling. The relaxation of thermal insulation requirements allows for a reduction in the stand-off distance between the sensor and the room-temperature environment from a few centimeters to less than a millimeter, where MEG signal strength is significantly higher. Despite this advantage, high-Tc SQUIDs have only been used for proof-of-principle MEG recordings of well-understood evoked activity. Here we show high-Tc SQUID-based MEG may be capable of providing novel information about brain activity due to the close proximity of the sensor to the head. We have performed single- and two-...

  15. Magnetoencephalography---theory, instrumentation, and applications to noninvasive studies of the working human brain

    International Nuclear Information System (INIS)

    Magnetoencephalography (MEG) is a noninvasive technique for investigating neuronal activity in the living human brain. The time resolution of the method is better than 1 ms and the spatial discrimination is, under favorable circumstances, 2--3 mm for sources in the cerebral cortex. In MEG studies, the weak 10 fT--1 pT magnetic fields produced by electric currents flowing in neurons are measured with multichannel SQUID (superconducting quantum interference device) gradiometers. The sites in the cerebral cortex that are activated by a stimulus can be found from the detected magnetic-field distribution, provided that appropriate assumptions about the source render the solution of the inverse problem unique. Many interesting properties of the working human brain can be studied, including spontaneous activity and signal processing following external stimuli. For clinical purposes, determination of the locations of epileptic foci is of interest. The authors begin with a general introduction and a short discussion of the neural basis of MEG. The mathematical theory of the method is then explained in detail, followed by a thorough description of MEG instrumentation, data analysis, and practical construction of multi-SQUID devices. Finally, several MEG experiments performed in the authors' laboratory are described, covering studies of evoked responses and of spontaneous activity in both healthy and diseased brains. Many MEG studies by other groups are discussed briefly as well

  16. Cognitive impairments in schizophrenia as assessed through activation and connectivity measures of magnetoencephalography (MEG data

    Directory of Open Access Journals (Sweden)

    Leighton B Hinkley

    2010-11-01

    Full Text Available The cognitive dysfunction present in patients with schizophrenia is thought to be driven in part by disorganized connections between higher-order cortical fields. Although studies utilizing EEG, PET and fMRI have contributed significantly to our understanding of these mechanisms, magnetoencephalography (MEG possesses great potential to answer long-standing questions linking brain interactions to cognitive operations in the disorder. Many experimental paradigms employed in EEG and fMRI are readily extendible to MEG and have expanded our understanding of the neurophysiological architecture present in schizophrenia. Source reconstruction techniques, such as adaptive spatial filtering, take advantage of the spatial localization abilities of MEG, allowing us to evaluate which specific structures contribute to atypical cognition in schizophrenia. Finally, both bivariate and multivariate functional connectivity metrics of MEG data are useful for understanding how these interactions in the brain are impaired in schizophrenia, and how cognitive and clinical outcomes are affected as a result. We also present here data from our own laboratory that illustrates how some of these novel functional connectivity measures, specifically imaginary coherence (IC, are quite powerful in relating disconnectivity in the brain to characteristic behavioral findings in the disorder.

  17. Functional mapping of the sensorimotor cortex: combined use of magnetoencephalography, functional MRI, and motor evoked potentials

    International Nuclear Information System (INIS)

    Combined use of magnetoencephalography (MEG), functional magnetic resonance imaging (f-MRI), and motor evoked potentials (MEPs) was carried out on one patient in an attempt to localise precisely a structural lesion to the central sulcus. A small cyst in the right frontoparietal region was thought to be the cause of generalised seizures in an otherwise asymptomatic woman. First the primary sensory cortex was identified with magnetic source imaging (MSI) of somatosensory evoked magnetic fields using MEG and MRI. Second, the motor area of the hand was identified using f-MRI during handsqueezing. Then transcranial magnetic stimulation localised the hand motor area on the scalp, which was mapped onto the MRI. There was a good agreement between MSI, f-MRI and MEP as to the location of the sensorimotor cortex and its relationship to the lesion. Multimodality mapping techniques may thus prove useful in the precise localisation of cortical lesions, and in the preoperative determination of the best treatment for peri-rolandic lesions. (orig.)

  18. Assessment of hemispheric dominance for receptive language in pediatric patients under sedation using magnetoencephalography

    Science.gov (United States)

    Rezaie, Roozbeh; Narayana, Shalini; Schiller, Katherine; Birg, Liliya; Wheless, James W.; Boop, Frederick A.; Papanicolaou, Andrew C.

    2014-01-01

    Non-invasive assessment of hemispheric dominance for receptive language using magnetoencephalography (MEG) is now a well-established procedure used across several epilepsy centers in the context of pre-surgical evaluation of children and adults while awake, alert and attentive. However, the utility of MEG for the same purpose, in cases of sedated patients, is contested. Establishment of the efficiency of MEG is especially important in the case of children who, for a number of reasons, must be assessed under sedation. Here we explored the efficacy of MEG language mapping under sedation through retrospective review of 95 consecutive pediatric patients, who underwent our receptive language test as part of routine clinical evaluation. Localization of receptive language cortex and subsequent determination of laterality was successfully completed in 78% (n = 36) and 55% (n = 27) of non-sedated and sedated patients, respectively. Moreover, the proportion of patients deemed left hemisphere dominant for receptive language did not differ between non-sedated and sedated patients, exceeding 90% in both groups. Considering the challenges associated with assessing brain function in pediatric patients, the success of passive MEG in the context of the cases reviewed in this study support the utility of this method in pre-surgical receptive language mapping. PMID:25191260

  19. Assessment of hemispheric dominance for receptive language in pediatric patients under sedation using magnetoencephalography

    Directory of Open Access Journals (Sweden)

    Roozbeh Rezaie

    2014-08-01

    Full Text Available Non-invasive assessment of hemispheric dominance for receptive language using Magnetoencephalography (MEG is now a well-established procedure used across several epilepsy centers in the context of pre-surgical evaluation of children and adults while awake, alert and attentive. However, the utility of MEG for the same purpose, in cases of sedated patients, is contested. Establishment of the efficiency of MEG is especially important in the case of children who, for a number of reasons, must be assessed under sedation. Here we explored the efficacy of MEG language mapping under sedation through retrospective review of 95 consecutive pediatric patients, who underwent our receptive language test as part of routine clinical evaluation. Localization of receptive language cortex and subsequent determination of laterality was successfully completed in 78% (n=36 and 55% (n=27 of non-sedated and sedated patients, respectively. Moreover, the proportion of patients deemed left hemisphere dominant for receptive language did not differ between non-sedated and sedated patients, exceeding 90% in both groups. Considering the challenges associated with assessing brain function in pediatric patients, the success of passive MEG in the context of the cases reviewed in this study support the utility of this method in pre-surgical receptive language mapping.

  20. A magnetoencephalography study of multi-modal processing of pain anticipation in primary sensory cortices.

    Science.gov (United States)

    Gopalakrishnan, R; Burgess, R C; Plow, E B; Floden, D P; Machado, A G

    2015-09-24

    Pain anticipation plays a critical role in pain chronification and results in disability due to pain avoidance. It is important to understand how different sensory modalities (auditory, visual or tactile) may influence pain anticipation as different strategies could be applied to mitigate anticipatory phenomena and chronification. In this study, using a countdown paradigm, we evaluated with magnetoencephalography the neural networks associated with pain anticipation elicited by different sensory modalities in normal volunteers. When encountered with well-established cues that signaled pain, visual and somatosensory cortices engaged the pain neuromatrix areas early during the countdown process, whereas the auditory cortex displayed delayed processing. In addition, during pain anticipation, the visual cortex displayed independent processing capabilities after learning the contextual meaning of cues from associative and limbic areas. Interestingly, cross-modal activation was also evident and strong when visual and tactile cues signaled upcoming pain. Dorsolateral prefrontal cortex and mid-cingulate cortex showed significant activity during pain anticipation regardless of modality. Our results show pain anticipation is processed with great time efficiency by a highly specialized and hierarchical network. The highest degree of higher-order processing is modulated by context (pain) rather than content (modality) and rests within the associative limbic regions, corroborating their intrinsic role in chronification. PMID:26210576

  1. Time modulated prefrontal and parietal activity during the maintenance of integrated information as revealed by magnetoencephalography.

    Science.gov (United States)

    Campo, Pablo; Maestú, Fernando; Ortiz, Tomás; Capilla, Almudena; Santiuste, Marta; Fernández, Alberto; Amo, Carlos

    2005-02-01

    Using magnetoencephalography, we investigated the spatiotemporal patterns of brain magnetic activity responsible for maintaining verbal and spatial information in either an integrated or an unintegrated fashion. Considering time dimension, we noted a greater activation of a fronto-parietal network in early latencies during the maintenance of integrated information, and a different pattern during the maintenance of unintegrated material, showing a greater activation in a fronto-posterior network in late latencies. The greater activation found in certain areas which are traditionally reported as being engaged in spatial working memory (i.e. superior frontal gyri, dorsolateral prefrontal cortex, superior and inferior parietal lobes) when subjects maintained integrated information could be explained by a greater weight of the spatial dimension. It is as if words somehow acquired a spatial attribute, thus exerting a greater load in a neural network specialized in spatial working memory. Alternatively, and not mutually exclusive, we also propose that during the maintenance of integrated information the allocation of cognitive resources is less interfering than during the maintenance of unintegrated information, making it easier. PMID:15238441

  2. Eficacia de los imanes permanentes multipolares en el tratamiento del dolor crónico en pacientes con osteoartrosis generalizada / Effectiveness of the multipolar permanent magnets in the treatment of chronic pain in patients with generalized osteoarthrosis

    Scientific Electronic Library Online (English)

    Mario, Hechavarría Sánchez; Mercedes, Gay Muguercia; César, Hernández Acosta; Luis Enrique, Bergues Cabrales.

    2013-11-01

    Full Text Available Se efectuó un estudio longitudinal y controlado de 100 pacientes con osteoartrosis generalizada, atendidos en el Servicio de Medicina Natural y Tradicional del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres" de Santiago de Cuba, desde enero hasta diciembre del 2010, a fin de ev [...] aluar la eficacia de los imanes permanentes multipolares en el tratamiento del dolor crónico en los afectados. Estos imanes se ubicaron y fijaron en diferentes puntos de acupunturas para aliviar la dolencia. Los niveles de dolor se cuantificaron mediante la Escala Visual Análoga, por sexo y rango de edades; se evaluaron a los 0, 30, 60 y 90 días durante la terapia. Se demostró la factibilidad del uso de los imanes permanentes multipolares en el alivio del dolor de los pacientes con osteoartrosis generalizada por ser simples, seguros, eficaces y no inducir efectos adversos en el organismo. Abstract in english A longitudinal and controlled study of 100 patients with generalized osteoarthrosis, assisted in the Service of Natural and Traditional Medicine of "Saturnino Lora Torres" Clinical Surgical Teaching Provincial Hospital in Santiago de Cuba was carried out from January to December, 2010, in order to e [...] valuate the effectiveness of the multipolar permanent magnets in the treatment of the chronic pain in those affected. These magnets were placed and fixed in different acupuncture points to reduce pain. The pain levels were quantified by means of the Analogue Visual Scale, by sex and age range; they were evaluated at the 0, 30, 60 and 90 days during the therapy. The feasibility of the use of the multipolar permanent magnets was demonstrated in the relief of pain of the patients with generalized osteoarthrosis as they are simple, sure, effective and induce no adverse effects in the organism.

  3. Self-assembly characteristics of a multipolar donor-acceptor-based bis-pyrene integrated molecular tweezer

    Indian Academy of Sciences (India)

    Deepak Asthana; Geeta Hundal; Pritam Mukhopadhyay

    2014-09-01

    A modular design of a molecular tweezer is presented that integrates a multipolar D--A [D: Donor, A: Acceptor] scaffold, 1-aminopyrene-based fluorophore units and L-alanine-based linkers. The synthesis of the molecule is based on two-fold aromatic nucleophilic reactions (ArSN) and coupling reactions of the acid and amino functionalities. This molecule crystallizes in a non-centrosymmteric (P21) space group.We present its rich self-assembly characteristics that involves an array of -stacking interactions. In addition, the molecular tweezer within its cleft forms H-bonding with two dimethylformamide molecules. Such multipolar D--A systems containing chiral and fluorophore units are potential candidatesfor a number of electronic and photonic applications.

  4. Eficacia de los imanes permanentes multipolares en el tratamiento del dolor crónico en pacientes con osteoartrosis generalizada

    Directory of Open Access Journals (Sweden)

    Mario Hechavarría Sánchez

    2013-11-01

    Full Text Available Se efectuó un estudio longitudinal y controlado de 100 pacientes con osteoartrosis generalizada, atendidos en el Servicio de Medicina Natural y Tradicional del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora Torres" de Santiago de Cuba, desde enero hasta diciembre del 2010, a fin de evaluar la eficacia de los imanes permanentes multipolares en el tratamiento del dolor crónico en los afectados. Estos imanes se ubicaron y fijaron en diferentes puntos de acupunturas para aliviar la dolencia. Los niveles de dolor se cuantificaron mediante la Escala Visual Análoga, por sexo y rango de edades; se evaluaron a los 0, 30, 60 y 90 días durante la terapia. Se demostró la factibilidad del uso de los imanes permanentes multipolares en el alivio del dolor de los pacientes con osteoartrosis generalizada por ser simples, seguros, eficaces y no inducir efectos adversos en el organismo.

  5. Plasmonic abilities of gold and silver spherical nanoantennas in terms of size dependent multipolar resonance frequencies and plasmon damping rates

    CERN Document Server

    Kolwas, Krystyna; 10.2478/s11772-010-0043-6

    2011-01-01

    Absorbing and emitting optical properties of a spherical plasmonic nanoantenna are described in terms of the size dependent resonance frequencies and damping rates of the multipolar surface plasmons (SP). We provide the plasmon size characteristics for gold and silver spherical particles up to the large size retardation regime where the plasmon radiative damping is significant. We underline the role of the radiation damping in comparison with the energy dissipation damping in formation of receiving and transmitting properties of a plasmonic particle. The size dependence of both: the multipolar SP resonance frequencies and corresponding damping rates can be a convenient tool in tailoring the characteristics of plasmonic nanoantennas for given application. Such characteristics enable to control an operation frequency of a plasmonic nanoantenna and to change the operation range from the spectrally broad to spectrally narrow and vice versa. It is also possible to switch between particle receiving (enhanced absorp...

  6. Multipolarity analysis for 14C high-energy resonance populated by (18O,16O) two-neutron transfer reaction

    Science.gov (United States)

    Carbone, D.; Cappuzzello, F.; Cavallaro, M.; Bond?, M.; Agodi, C.; Azaiez, F.; Bonaccorso, A.; Cunsolo, A.; Fortunato, L.; Foti, A.; Franchoo, S.; Khan, E.; Linares, R.; Lubian, J.; Scarpaci, J. A.; Vitturi, A.

    2015-10-01

    The 12C(18O,16O)14C reaction at 84 MeV incident energy has been explored up to high excitation energy of the residual nucleus thanks to the use of the MAGNEX spectrometer to detect the ejectiles. In the region above the two-neutron separation energy, a resonance has been observed at 16.9 MeV. A multipolarity analysis of the cross section angular distribution indicates an L = 0 character for such a transition.

  7. Properties of highly electronegative plasmas produced in a multipolar magnetic-confined device with a transversal magnetic filter

    DEFF Research Database (Denmark)

    Draghici, Mihai; Stamate, Eugen

    2010-01-01

    Highly electronegative plasmas were produced in Ar/SF6 gas mixtures in a dc discharge with multipolar magnetic confinement and transversal magnetic filter. Langmuir probe and mass spectrometry were used for plasma diagnostics. Plasma potential drift, the influence of small or large area biased electrodes on plasma parameters, the formation of the negative ion sheath and etching rates by positive and negative ions have been investigated for different experimental conditions. When the electron tem...

  8. Multipolar radiofrequency ablation using 4–6 applicators simultaneously: A study in the ex vivo bovine liver

    Energy Technology Data Exchange (ETDEWEB)

    Stoffner, Rudolf, E-mail: rudi_stoffner@hotmail.com [Innsbruck Medical University, Department of Radiology, Anichstr. 35, A-6020 Innsbruck (Austria); Kremser, Christian, E-mail: Christian.Kremser@i-med.ac.at [Innsbruck Medical University, Department of Radiology, Anichstr. 35, A-6020 Innsbruck (Austria); Schullian, Peter, E-mail: Peter.Schullian@i-med.ac.at [Innsbruck Medical University, Department of Radiology, Anichstr. 35, A-6020 Innsbruck (Austria); Haidu, Marion, E-mail: Marion.Haidu@i-med.ac.at [Innsbruck Medical University, Department of Radiology, Anichstr. 35, A-6020 Innsbruck (Austria); Widmann, Gerlig, E-mail: Gerlig.Widmann@i-med.ac.at [Innsbruck Medical University, Department of Radiology, Anichstr. 35, A-6020 Innsbruck (Austria); Bale, Reto J., E-mail: Reto.Bale@i-med.ac.at [Innsbruck Medical University, Department of Radiology, Anichstr. 35, A-6020 Innsbruck (Austria)

    2012-10-15

    In this study the volume and shape of coagulation zones after multipolar radiofrequency ablation (RFA) with simultaneous use of 4–6 applicators in the ex vivo bovine liver were investigated. The RF-applicators were positioned in 13 different configurations to simulate ablation of large solitary tumors and simultaneous ablation of multiple lesions with 120 kJ of applied energy/session. In total, 110 coagulation zones were induced. Standardized measurements of the volume and shape of the coagulation zones were carried out on magnetic resonance images and statistically analyzed. The coagulation zones induced with solitary applicators and with 2 applicators were imperceptibly small and incomplete, respectively. At 20 mm applicator distance, the total ablated volume was significantly larger if all applicators were arranged in a single group compared to placement in 2 distant applicator groups, each consisting of 3 applicators (p = .001). The mean total coagulated volume ranged from immeasurably small (if 6 solitary applicators were applied simultaneously) to 74.7 cc (if 6 applicators at 30 mm distance between neighboring applicators were combined to a single group). Applicator distance, number and positioning array impacted time and shape. The coagulation zones surrounding groups with 4–6 applicators were regularly shaped, homogeneous and completely fused, and the axial diameters were almost constant. In conclusion, multipolar RFA with 4–6 applicators is feasible. The multipolar simultaneous mode should be applied for large and solitary lesions only, small and multiple tumors should be ablated consecutively in standard multipolar mode with up to 3 applicators.

  9. Improvement of an on-line electron spectrometer. Determination of transition multipolarity. Application to 102Ag and 108In

    International Nuclear Information System (INIS)

    The aim of this work has been to optimize the transmission, resolution and background of an electron 'Orange' spectrometer, set-up on-line at the Grenoble isochronous cyclotron. The transitions multipolarities in 102Ag and 108In nuclei have been determined measuring the internal conversion coefficients and a cascade of five pure transitions Ml without cross-over E2 has been found in 108In

  10. Suppressive responses by visual food cues in postprandial activities of insular cortex as revealed by magnetoencephalography.

    Science.gov (United States)

    Yoshikawa, Takahiro; Tanaka, Masaaki; Ishii, Akira; Watanabe, Yasuyoshi

    2014-06-01

    'Hara-Hachibu' in Japanese means a subjective sense by which we stop eating just before the motivation to eat is completely lost, a similar concept to caloric restriction (CR). Insular cortex is a critical platform which integrates sensory information into decision-making processes in eating behavior. We compared the responses of insular cortex, as assessed by magnetoencephalography (MEG), immediately after presentation of food images in the Fasting condition with those in the 'Hara-Hachibu' condition. Eleven healthy, right-handed males [age, 27.2±9.6 years; body mass index, 22.6±2.1kg/m(2) (mean±SD)] were enrolled in a randomized, two-crossover experiment (Fasting and 'Hara-Hachibu' conditions). Before the MEG recordings in the 'Hara-Hachibu' condition, the participants consumed rice balls as much as they judged themselves to have consumed shortly before reaching satiety. During the MEG recordings, they viewed food pictures projected on a screen. The intensities of MEG responses to viewing food pictures were significantly lower in the 'Hara-Hachibu' condition than those in the Fasting condition (Pfood stimuli in the 'Hara-Hachibu' condition was positively associated with the factor-3 (food tasted) (r=0.693, P=0.018) and aggregated scores (r=0.659, P=0.027) of the Power of Food Scale, a self-report measure of hedonic hunger. These findings may help to elucidate the neural basis of variability of appetite phenotypes under the condition of CR among individuals, and to develop possible strategies for the maintenance of adequate CR in daily life. PMID:24768717

  11. Spatial variability in cortex-muscle coherence investigated with magnetoencephalography and high-density surface electromyography.

    Science.gov (United States)

    Piitulainen, Harri; Botter, Alberto; Bourguignon, Mathieu; Jousmäki, Veikko; Hari, Riitta

    2015-11-01

    Cortex-muscle coherence (CMC) reflects coupling between magnetoencephalography (MEG) and surface electromyography (sEMG), being strongest during isometric contraction but absent, for unknown reasons, in some individuals. We used a novel nonmagnetic high-density sEMG (HD-sEMG) electrode grid (36 mm × 12 mm; 60 electrodes separated by 3 mm) to study effects of sEMG recording site, electrode derivation, and rectification on the strength of CMC. Monopolar sEMG from right thenar and 306-channel whole-scalp MEG were recorded from 14 subjects during 4-min isometric thumb abduction. CMC was computed for 60 monopolar, 55 bipolar, and 32 Laplacian HD-sEMG derivations, and two derivations were computed to mimic "macroscopic" monopolar and bipolar sEMG (electrode diameter 9 mm; interelectrode distance 21 mm). With unrectified sEMG, 12 subjects showed statistically significant CMC in 91-95% of the HD-sEMG channels, with maximum coherence at ?25 Hz. CMC was about a fifth stronger for monopolar than bipolar and Laplacian derivations. Monopolar derivations resulted in most uniform CMC distributions across the thenar and in tightest cortical source clusters in the left rolandic hand area. CMC was 19-27% stronger for HD-sEMG than for "macroscopic" monopolar or bipolar derivations. EMG rectification reduced the CMC peak by a quarter, resulted in a more uniformly distributed CMC across the thenar, and provided more tightly clustered cortical sources than unrectifed sEMGs. Moreover, it revealed CMC at ?12 Hz. We conclude that HD-sEMG, especially with monopolar derivation, can facilitate detection of CMC and that individual muscle anatomy cannot explain the high interindividual CMC variability. PMID:26354317

  12. Test-retest reliability of resting-state magnetoencephalography power in sensor and source space.

    Science.gov (United States)

    Martín-Buro, María Carmen; Garcés, Pilar; Maestú, Fernando

    2016-01-01

    Several studies have reported changes in spontaneous brain rhythms that could be used as clinical biomarkers or in the evaluation of neuropsychological and drug treatments in longitudinal studies using magnetoencephalography (MEG). There is an increasing necessity to use these measures in early diagnosis and pathology progression; however, there is a lack of studies addressing how reliable they are. Here, we provide the first test-retest reliability estimate of MEG power in resting-state at sensor and source space. In this study, we recorded 3 sessions of resting-state MEG activity from 24 healthy subjects with an interval of a week between each session. Power values were estimated at sensor and source space with beamforming for classical frequency bands: delta (2-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), low beta (13-20 Hz), high beta (20-30 Hz), and gamma (30-45 Hz). Then, test-retest reliability was evaluated using the intraclass correlation coefficient (ICC). We also evaluated the relation between source power and the within-subject variability. In general, ICC of theta, alpha, and low beta power was fairly high (ICC?>?0.6) while in delta and gamma power was lower. In source space, fronto-posterior alpha, frontal beta, and medial temporal theta showed the most reliable profiles. Signal-to-noise ratio could be partially responsible for reliability as low signal intensity resulted in high within-subject variability, but also the inherent nature of some brain rhythms in resting-state might be driving these reliability patterns. In conclusion, our results described the reliability of MEG power estimates in each frequency band, which could be considered in disease characterization or clinical trials. Hum Brain Mapp 37:179-190, 2016. © 2015 Wiley Periodicals, Inc. PMID:26467848

  13. Visual and auditory stimuli associated with swallowing activate mirror neurons: a magnetoencephalography study.

    Science.gov (United States)

    Ushioda, Takashi; Watanabe, Yutaka; Sanjo, Yusuke; Yamane, Gen-Yuki; Abe, Shinichi; Tsuji, Yusuke; Ishiyama, Atushi

    2012-12-01

    In the present study, we evaluated activated areas of the cerebral cortex with regard to the mirror neuron system during swallowing. To identify the activated areas, we used magnetoencephalography. Subjects were ten consenting volunteers. Swallowing-related stimuli comprised an animated image of the left profile of a person swallowing water with laryngeal elevation as a visual swallowing trigger stimulus and a swallowing sound as an auditory swallowing trigger stimulus. As control stimuli, a still frame image of the left profile without an additional trigger was shown, and an artificial sound as a false auditory trigger was provided. Triggers were presented at 3,000 ms after the start of image presentation. The stimuli were combined and presented and the areas activated were identified for each stimulus. With animation and still-frame stimuli, the visual association area (Brodmann area (BA) 18) was activated at the start of image presentation, while with the swallowing sound and artificial sound stimuli, the auditory areas BA 41 and BA 42 were activated at the time of trigger presentation. However, with animation stimuli (animation stimulus, animation + swallowing sound stimuli, and animation + artificial sound stimuli), activation in BA 6 and BA 40, corresponding to mirror neurons, was observed between 620 and 720 ms before the trigger. Besides, there were also significant differences in latency time and peak intensity between animation stimulus and animation + swallowing sound stimuli. Our results suggest that mirror neurons are activated by swallowing-related visual and auditory stimuli. PMID:22395851

  14. Cortical activity associated with the detection of temporal gaps in tones: A magnetoencephalography study

    Directory of Open Access Journals (Sweden)

    Takako Mitsudo

    2014-10-01

    Full Text Available We used magnetoencephalography (MEG in two experiments to investigate spatio-temporal profiles of brain responses to gaps in tones. Stimuli consisted of leading and trailing markers with gaps between the two markers of 0, 30, or 80 ms. Leading and trailing markers were 300 ms pure tones at 800 Hz or 3200 Hz. Two conditions were examined: the within-frequency (WF condition in which the leading and trailing markers had identical frequencies, and the between-frequency (BF condition in which they had different frequencies. Using minimum-norm estimates (MNE, we localized the source activations at the time of the peak response to the trailing markers. Results showed that MEG signals in response to 800 Hz and 3200 Hz tones were localized in different regions within the auditory cortex, indicating that the frequency pathways activated by the two markers were spatially represented. The time course of regional activity (RA was extracted from each localized region for each condition. In Experiment 1, which used a continuous tone for the WF 0-ms stimulus, the N1m amplitude for the trailing marker in the WF condition differed depending on gap duration but not tonal frequency. In contrast, N1m amplitude in BF conditions differed depending on the frequency of the trailing marker. In Experiment 2, in which the 0-ms gap stimulus in the WF condition was made from two markers and included an amplitude reduction in the middle, the amplitude in WF and BF conditions changed depending on frequency, but not gap duration. The difference in temporal characteristics between WF and BF conditions could be observed in the regional activity.

  15. Neutron star deformation due to arbitrary-order multipolar magnetic fields

    CERN Document Server

    Mastrano, Alpha; Melatos, Andrew

    2013-01-01

    Certain multi-wavelength observations of neutron stars, such as intermittent radio emissions from rotation-powered pulsars beyond the pair-cascade death line, the pulse profile of the magnetar SGR 1900+14 after its 1998 August 27 giant flare, and X-ray spectral features of PSR J0821-4300 and SGR 0418+5729, suggest that the magnetic fields of non-accreting neutron stars are not purely dipolar and may contain higher-order multipoles. Here, we calculate the ellipticity of a non-barotropic neutron star with (i) a quadrupole poloidal-toroidal field, and (ii) a purely poloidal field containing arbitrary multipoles, deriving the relation between the ellipticity and the multipole amplitudes. We present, as a worked example, a purely poloidal field comprising dipole, quadrupole, and octupole components. We show the correlation between field energy and ellipticity for each multipole, that the l=4 multipole has the lowest energy, and that l=5 has the lowest ellipticity. We show how a mixed multipolar field creates an ob...

  16. Parities and multipolarities of gamma rays in neutron-rich odd-mass Ba nuclei

    International Nuclear Information System (INIS)

    The nuclei 143,145,147Ba produced in the spontaneous fission of 248Cm have been studied using the EUROGAM phase II array. The parities and multipolarities of γ rays in these nuclei have been assigned from triple angular correlation, directional linear-polarisation correlation and internal conversion coefficient measurements. These data confirm an alternating-parity sequence connected by strong electric dipole transitions in 143Ba. They also reveal a more weakly populated, complementary alternating-parity sequence. The two sequences together exhibit some characteristics of parity-doublet bands. Interpreting the E1 strengths in terms of a rotating intrinsic dipole moment gives a moment similar in size to that observed in 142Ba and 144Ba. No well-developed similar structure is seen in 145Ba, although E1 transitions are observed, from which a value of the dipole moment is obtained. This value is smaller than the moment observed in 143Ba. No features appropriate to strong octupole correlations were observed in 147Ba. (orig.)

  17. The Evolutionary Dynamics of Biofuel Value Chains : From Unipolar and Government-Driven to Multipolar Governance

    DEFF Research Database (Denmark)

    Ponte, Stefano

    2014-01-01

    In this paper I propose to push the frontier of global value chain (GVC) governance analysis through the concept of ‘polarity’. Much of the existing GVC literature has focused on ‘unipolar’ value chains, where one group of ‘lead firms’ inhabiting a specific function in a chain plays a dominant role in governing it. Some scholars have explored the dynamics of governance in GVCs characterized as ‘bipolar’, where two sets of actors in different functional positions both drive the chain. I expand this direction further to suggest conceptualizing governance within a continuum between unipolarity and multipolarity. Empirically, I do so by examining the evolutionary dynamics of governance in biofuel value chains, with specific focus on the key regulatory and institutional features that facilitated their emergence and expansion. First, I examine the formation, evolution, and governance of three national/regional value chains (in Brazil, the US, and the EU); then, I provide evidence to support a trend towards the increasing but still partial formation of a global biofuel value chain and examine its governance traits.

  18. Strong orbital fluctuations in multipolar ordered states of PrV2Al20

    Science.gov (United States)

    Matsumoto, Yosuke; Tsujimoto, Masaki; Tomita, Takahiro; Sakai, Akito; Nakatsuji, Satoru

    2016-02-01

    PrT2Al20 (T=Ti, V) are ideal systems to study the quadrupole Kondo effect and quantum criticality arising from orbital degrees of freedom. The both systems have the nonmagnetic cubic ?3 crystal electric field ground doublet with the well separated excited state. In particular, PrV2Al20 exhibits anomalous metallic behavior above and below the multipolar ordering temperatures, reflecting the even stronger hybridization between f and conduction electrons possibly due to a proximity to an orbital quantum critical point. Here we report the anomalous metallic behaviors found in a pure single crystal of PrV2Al20. Our detailed analyses revealed that the resistivity indicates power law temperature dependence proportional to T3. Furthermore, we pointed out that the 4f electron contribution to the specific heat also exhibits power law behavior proportional to T4. Both observations are in a sharp contrast to the gapped behavior found in PrTi2Al20 and indicate the strong c-f hybridization and strong orbital fluctuations in PrV2Al20. In addition, the 4f electron contribution to the entropy in PrV2Al20 reaches only 50% of R ln 2 at an orbital ordering at T=0.75 K, suggesting another 50% of R ln 2 expected for ?3 doublet is already released at higher temperature possibly due to quadrupole Kondo effect.

  19. CT-guided Bipolar and Multipolar Radiofrequency Ablation (RF Ablation) of Renal Cell Carcinoma: Specific Technical Aspects and Clinical Results

    International Nuclear Information System (INIS)

    Purpose. This study was designed to evaluate the clinical efficacy of CT-guided bipolar and multipolar radiofrequency ablation (RF ablation) of renal cell carcinoma (RCC) and to analyze specific technical aspects between both technologies. Methods. We included 22 consecutive patients (3 women; age 74.2 ± 8.6 years) after 28 CT-guided bipolar or multipolar RF ablations of 28 RCCs (diameter 2.5 ± 0.8 cm). Procedures were performed with a commercially available RF system (Celon AG Olympus, Berlin, Germany). Technical aspects of RF ablation procedures (ablation mode [bipolar or multipolar], number of applicators and ablation cycles, overall ablation time and deployed energy, and technical success rate) were analyzed. Clinical results (local recurrence-free survival and local tumor control rate, renal function [glomerular filtration rate (GFR)]) and complication rates were evaluated. Results. Bipolar RF ablation was performed in 12 procedures and multipolar RF ablation in 16 procedures (2 applicators in 14 procedures and 3 applicators in 2 procedures). One ablation cycle was performed in 15 procedures and two ablation cycles in 13 procedures. Overall ablation time and deployed energy were 35.0 ± 13.6 min and 43.7 ± 17.9 kJ. Technical success rate was 100 %. Major and minor complication rates were 4 and 14 %. At an imaging follow-up of 15.2 ± 8.8 months, local recurrence-free survival was 14.4 ± 8.8 months and local tumor control rate was 93 %. GFR did not deteriorate after RF ablation (50.8 ± 16.6 ml/min/1.73 m2 before RF ablation vs. 47.2 ± 11.9 ml/min/1.73 m2 after RF ablation; not significant). Conclusions. CT-guided bipolar and multipolar RF ablation of RCC has a high rate of clinical success and low complication rates. At short-term follow-up, clinical efficacy is high without deterioration of the renal function.

  20. CT-guided Bipolar and Multipolar Radiofrequency Ablation (RF Ablation) of Renal Cell Carcinoma: Specific Technical Aspects and Clinical Results

    Energy Technology Data Exchange (ETDEWEB)

    Sommer, C. M., E-mail: christof.sommer@med.uni-heidelberg.de [University Hospital Heidelberg, INF 110, Department of Diagnostic and Interventional Radiology (Germany); Lemm, G.; Hohenstein, E. [Minimally Invasive Therapies and Nuclear Medicine, SLK Kliniken Heilbronn GmbH, Clinic for Radiology (Germany); Bellemann, N.; Stampfl, U. [University Hospital Heidelberg, INF 110, Department of Diagnostic and Interventional Radiology (Germany); Goezen, A. S.; Rassweiler, J. [Clinic for Urology, SLK Kliniken Heilbronn GmbH (Germany); Kauczor, H. U.; Radeleff, B. A. [University Hospital Heidelberg, INF 110, Department of Diagnostic and Interventional Radiology (Germany); Pereira, P. L. [Minimally Invasive Therapies and Nuclear Medicine, SLK Kliniken Heilbronn GmbH, Clinic for Radiology (Germany)

    2013-06-15

    Purpose. This study was designed to evaluate the clinical efficacy of CT-guided bipolar and multipolar radiofrequency ablation (RF ablation) of renal cell carcinoma (RCC) and to analyze specific technical aspects between both technologies. Methods. We included 22 consecutive patients (3 women; age 74.2 {+-} 8.6 years) after 28 CT-guided bipolar or multipolar RF ablations of 28 RCCs (diameter 2.5 {+-} 0.8 cm). Procedures were performed with a commercially available RF system (Celon AG Olympus, Berlin, Germany). Technical aspects of RF ablation procedures (ablation mode [bipolar or multipolar], number of applicators and ablation cycles, overall ablation time and deployed energy, and technical success rate) were analyzed. Clinical results (local recurrence-free survival and local tumor control rate, renal function [glomerular filtration rate (GFR)]) and complication rates were evaluated. Results. Bipolar RF ablation was performed in 12 procedures and multipolar RF ablation in 16 procedures (2 applicators in 14 procedures and 3 applicators in 2 procedures). One ablation cycle was performed in 15 procedures and two ablation cycles in 13 procedures. Overall ablation time and deployed energy were 35.0 {+-} 13.6 min and 43.7 {+-} 17.9 kJ. Technical success rate was 100 %. Major and minor complication rates were 4 and 14 %. At an imaging follow-up of 15.2 {+-} 8.8 months, local recurrence-free survival was 14.4 {+-} 8.8 months and local tumor control rate was 93 %. GFR did not deteriorate after RF ablation (50.8 {+-} 16.6 ml/min/1.73 m{sup 2} before RF ablation vs. 47.2 {+-} 11.9 ml/min/1.73 m{sup 2} after RF ablation; not significant). Conclusions. CT-guided bipolar and multipolar RF ablation of RCC has a high rate of clinical success and low complication rates. At short-term follow-up, clinical efficacy is high without deterioration of the renal function.

  1. BabySQUID: A mobile, high-resolution multichannel magnetoencephalography system for neonatal brain assessment

    Science.gov (United States)

    Okada, Yoshio; Pratt, Kevin; Atwood, Christopher; Mascarenas, Anthony; Reineman, Richard; Nurminen, Jussi; Paulson, Douglas

    2006-02-01

    We developed a prototype of a mobile, high-resolution, multichannel magnetoencephalography (MEG) system, called babySQUID, for assessing brain functions in newborns and infants. Unlike electroencephalography, MEG signals are not distorted by the scalp or the fontanels and sutures in the skull. Thus, brain activity can be measured and localized with MEG as if the sensors were above an exposed brain. The babySQUID is housed in a moveable cart small enough to be transported from one room to another. To assess brain functions, one places the baby on the bed of the cart and the head on its headrest with MEG sensors just below. The sensor array consists of 76 first-order axial gradiometers, each with a pickup coil diameter of 6mm and a baseline of 30mm, in a high-density array with a spacing of 12-14mm center-to-center. The pickup coils are 6±1mm below the outer surface of the headrest. The short gap provides unprecedented sensitivity since the scalp and skull are thin (as little as 3-4mm altogether) in babies. In an electromagnetically unshielded room in a hospital, the field sensitivity at 1kHz was ˜17fT/?Hz. The noise was reduced from ˜400to200fT/?Hz at 1Hz using a reference cancellation technique and further to ˜40fT/?Hz using a gradient common mode rejection technique. Although the residual environmental magnetic noise interfered with the operation of the babySQUID, the instrument functioned sufficiently well to detect spontaneous brain signals from babies with a signal to noise ratio (SNR) of as much as 7.6:1. In a magnetically shielded room, the field sensitivity was 17fT/?Hz at 20Hz and 30fT/?Hz at 1Hz without implementation of reference or gradient cancellation. The sensitivity was sufficiently high to detect spontaneous brain activity from a 7month old baby with a SNR as much as 40:1 and evoked somatosensory responses with a 50Hz bandwidth after as little as four averages. We expect that both the noise and the sensor gap can be reduced further by approximately half with a gain in SNR of about four. Thus, we conclude from the performance of the prototype that it should be feasible to improve the babySQUID to detect cortical activity in infants in real time with high spatial resolution.

  2. Evaluation of focused multipolar stimulation for cochlear implants in long-term deafened cats

    Science.gov (United States)

    George, Shefin S.; Wise, Andrew K.; Fallon, James B.; Shepherd, Robert K.

    2015-06-01

    Objective. Focused multipolar (FMP) stimulation has been shown to produce restricted neural activation using intracochlear stimulation in animals with a normal population of spiral ganglion neurons (SGNs). However, in a clinical setting, the widespread loss of SGNs and peripheral fibres following deafness is expected to influence the effectiveness of FMP. Approach. We compared the efficacy of FMP stimulation to both monopolar (MP) and tripolar (TP) stimulation in long-term deafened cat cochleae (n = 8). Unlike our previous study, these cochleae contained electrode array. We also evaluated the effect of electrode position on stimulation modes by using either modiolar facing or lateral wall facing half-band electrodes. The spread of neural activity across the inferior colliculus, a major nucleus within the central auditory pathway, was used as a measure of spatial selectivity. Main results. In cochleae with significant SGN degeneration, we observed that FMP and TP stimulation resulted in greater spatial selectivity than MP stimulation (p referred as ‘partial-FMP’ stimulation). Spatial selectivity of all stimulation modes was unaffected by the electrode position. Finally, spatial selectivity in long-term deafened cochleae was significantly less than that of cochleae with normal SGN population (George S S et al 2014 J. Neural Eng. 11 065003). Significance. The present results indicate that the greater spatial selectivity of FMP and TP stimulation over MP stimulation is maintained in cochleae with significant neural degeneration and is not adversely affected by electrode position. The greater spatial selectivity of FMP and TP stimulation would be expected to result in improved clinical performance.

  3. [Morphometry of giant multipolar neurons of the brain stem reticular formation in rats on board the Kosmos-1667 biosatellite].

    Science.gov (United States)

    Belichenko, P V; Leontovich, T A

    1989-05-01

    Giant multipolar neurons of nucleus reticularis gigantocellularis of rats which had been kept on board the biosatellite "Kosmos-1667" were morphometrically studied. There was a trend towards the increase in the cellular surface, the maximum diameter of dendritic field, the volume of the whole dendritic territory in the test group ad in the control experimental group kept on the earth. A reliable decrease in dendritic mass oriented to nucleus vestibularis and an increase in dendritic mass oriented to the midline were also found in test group, as compared to 3 control groups. Our data were discussed in the light of nervous tissue plasticity in adult mammals. PMID:2736303

  4. The Kennaugh element framework for multi-scale, multi-polarized, multi-temporal and multi-frequency SAR image preparation

    Science.gov (United States)

    Schmitt, Andreas; Wendleder, Anna; Hinz, Stefan

    2015-04-01

    As the number of space-borne SAR sensors increases, a rising number of different SAR acquisition modes is in use, resulting in a higher variation within the image products. This variability in acquisition geometry, radiometry, and last but not least polarimetry raises the need for a consistent SAR image description incorporating all available sensors and acquisition modes. This paper therefore introduces the framework of the Kennaugh elements to comparably represent all kinds of multi-scale, multi-temporal, multi-polarized, multi-frequency, and hence, multi-sensor data in a consistent mathematical framework. Furthermore, a novel noise model is introduced that estimates the significance and thus the (polarimetric) information content of the Kennaugh elements. This facilitates an advanced filtering approach, called multi-scale multi-looking, which is shown to improve the radiometric accuracy while preserving the geometric resolution of SAR images. The proposed methodology is finally demonstrated using sample applications that include TerraSAR-X (X-band), Envisat-ASAR, RADARSAT-2 (C-band) and ALOS-PALSAR (L-band) data as well as the combination of all three frequencies. Thus the suitability of the Kennaugh element framework for practical use in proved for advanced SAR remote sensing.

  5. The frustrated ferromagnetic S = 1/2 Heisenberg chain in a magnetic field - How multipolar spin correlations emerge from magnetically ordered states

    Energy Technology Data Exchange (ETDEWEB)

    Laeuchli, Andreas M [Max Planck Institut fuer Physik komplexer Systeme, 01187 Dresden (Germany); Sudan, Julien; Luescher, Andreas, E-mail: laeuchli@comp-phys.or [Institut Romand de Recherche Numerique en Physique des Materiaux (IRRMA), 1015 Lausanne (Switzerland)

    2009-01-01

    We present the phase diagram of the frustrated ferromagnetic S = 1/2 Heisenberg J{sub 1}-J{sub 2} chain in a magnetic field, obtained by large scale exact diagonalizations and densitymatrix-renormalization-group simulations. A vector chirally ordered state, metamagnetic behavior and a sequence of spin multipolar Luttinger liquid phases up to hexadecupolar order are found. Starting from classical considerations, we point out that various multipolar correlations are imprinted in a magnetic state and that they can survive the onset of frustration and quantum fluctuations which destroy the conventional magnetic order. Our results also shed new light on previously discovered spin multipolar phases in two-dimensional S = 1/2 quantum magnets in a magnetic field.

  6. The Slope Imaging Multi-polarization Photon-counting Lidar: an Advanced Technology Airborne Laser Altimeter

    Science.gov (United States)

    Dabney, P.; Harding, D. J.; Huss, T.; Valett, S.; Yu, A. W.; Zheng, Y.

    2009-12-01

    The Slope Imaging Multi-polarization Photon-counting Lidar (SIMPL) is an airborne laser altimeter developed through the NASA Earth Science Technology Office Instrument Incubator Program with a focus on cryopshere remote sensing. The SIMPL instrument incorporates a variety of advanced technologies in order to demonstrate measurement approaches of potential benefit for improved airborne laser swath mapping and spaceflight laser altimeter missions. SIMPL incorporates beam splitting, single-photon ranging and polarimetry technologies at green and near-infrared wavelengths in order to achieve simultaneous sampling of surface elevation, slope, roughness and scattering properties, the latter used to differentiate surface types. The transmitter is a 1 nsec pulse width, 11 kHz, 1064 nm microchip laser, frequency doubled to 532 nm and split into four plane-polarized beams using birefringent calcite crystal in order to maintain co-alignment of the two colors. The 16 channel receiver splits the received energy for each beam into the two colors and each color is split into energy parallel and perpendicular to the transmit polarization plane thereby proving a measure of backscatter depolarization. The depolarization ratio is sensitive to the proportions of specular reflection and surface and volume scattering, and is a function of wavelength. The ratio can differentiate, for example, water, young translucent ice, older granular ice and snow. The solar background count rate is controlled by spatial filtering using a pinhole array and by spectral filtering using temperature-controlled narrow bandwidth filters. The receiver is fiber coupled to 16 Single Photon Counting Modules (SPCMs). To avoid range biases due to the long dead time of these detectors the probability of detection per laser fire on each channel is controlled to be below 30%, using mechanical irises and flight altitude. Event timers with 0.1 nsec resolution in combination the narrow transmit pulse yields single photon ranging precision of 8 cm. The high speed, high throughput data system is capable of recording 22 million time-tagged photon detection events per second. At typical aircraft flight speeds, each of the 16 channels acquires a single photon range every 5 to 15 cm along the four profiles providing a highly sampled measure of surface roughness. The nominal flight altitude is 5 km yielding 10 m spacing between the four beam profiles, providing a measure of surface slope at 10 m length scales. The altitude is currently constrained by the low signal level of the NIR cross-polarized channels. SIMPL’s measurement capabilities provide information about surface elevation, roughness, slope and type of value in characterizing ice sheet surfaces and sea ice, including their melt state. Capabilities will be illustrated using data acquired over Lake Erie ice cover in February, 2009.

  7. A multicenter study of the early detection of synaptic dysfunction in Mild Cognitive Impairment using Magnetoencephalography-derived functional connectivity

    Science.gov (United States)

    Maestú, Fernando; Peña, Jose-Maria; Garcés, Pilar; González, Santiago; Bajo, Ricardo; Bagic, Anto; Cuesta, Pablo; Funke, Michael; Mäkelä, Jyrki P.; Menasalvas, Ernestina; Nakamura, Akinori; Parkkonen, Lauri; López, Maria E.; del Pozo, Francisco; Sudre, Gustavo; Zamrini, Edward; Pekkonen, Eero; Henson, Richard N.; Becker, James T.

    2015-01-01

    Synaptic disruption is an early pathological sign of the neurodegeneration of Dementia of the Alzheimer's type (DAT). The changes in network synchronization are evident in patients with Mild Cognitive Impairment (MCI) at the group level, but there are very few Magnetoencephalography (MEG) studies regarding discrimination at the individual level. In an international multicenter study, we used MEG and functional connectivity metrics to discriminate MCI from normal aging at the individual person level. A labeled sample of features (links) that distinguished MCI patients from controls in a training dataset was used to classify MCI subjects in two testing datasets from four other MEG centers. We identified a pattern of neuronal hypersynchronization in MCI, in which the features that best discriminated MCI were fronto-parietal and interhemispheric links. The hypersynchronization pattern found in the MCI patients was stable across the five different centers, and may be considered an early sign of synaptic disruption and a possible preclinical biomarker for MCI/DAT. PMID:26448910

  8. Proposal for a new method for multipolarity determinations: an application of the electron-positron angular correlation in internal-pair transitions

    International Nuclear Information System (INIS)

    A combination of semicircular Si(Li) detectors with two magnetic lens spectrometers is shown to offer a possibility to construct an effective spectroscopic instrument for multipolarity determinations. The method is based on the fact that the angular correlation between the electron-positron pair is sensitive to multipolarity, even at high transition energies. Response characteristics and multipole discrimination power are given for different detection geometries. The calculations are based on the zero-order Born approximation (ZBA) and are sufficiently accurate at least for k>3 and Z<50. (author)

  9. Bisphenol A disrupts microtubules and induces multipolar spindles in dividing root tip cells of the gymnosperm Abies cephalonica.

    Science.gov (United States)

    Adamakis, Ioannis-Dimosthenis S; Panteris, Emmanuel; Eleftheriou, Eleftherios P

    2016-04-01

    The effects of bisphenol A (BPA), an endocrine chemical disruptor extensively used in the plastic and epoxy resin industry, on dividing root tip cells of the gymnosperm Abies cephalonica Loudon were investigated by confocal laser scanning microscopy after tubulin and endoplasmic reticulum immunolocalization and DNA staining. Microtubule arrays of all mitotic stages were disrupted within a few hours of treatment: preprophase bands exhibited asymmetric width; prometaphase, metaphase and anaphase spindles appeared sharply pointed, sigmoid or multipolar; phragmoplast microtubules were elongated and occasionally bended toward the daughter nuclei. Depending on the mitotic stage, the chromosomes appeared condensed at prophase, as a compact mass at metaphase and anaphase, unsegregated or bridged at telophase. Endoplasmic reticulum patterns were also affected, reflecting those of the respective microtubule arrays. Recovery of the microtubules after oryzalin treatment was more effective in a BPA solution than in water. It is concluded that the plant mitotic apparatus microtubules are very sensitive to BPA, the effect of which depends on the specific cell cycle stage. The formation of multipolar spindles is reminiscent of animal cells and is ascribed to the induction of multiple microtubule nucleation sites, deriving from the centrosomal properties of gymnosperms. PMID:26855225

  10. Ketamine Dysregulates the Amplitude and Connectivity of High-Frequency Oscillations in Cortical-Subcortical Networks in Humans: Evidence From Resting-State Magnetoencephalography-Recordings.

    Science.gov (United States)

    Rivolta, Davide; Heidegger, Tonio; Scheller, Bertram; Sauer, Andreas; Schaum, Michael; Birkner, Katharina; Singer, Wolf; Wibral, Michael; Uhlhaas, Peter J

    2015-09-01

    Hypofunctioning of the N-methyl-D-aspartate receptor (NMDA-R) has been prominently implicated in the pathophysiology of schizophrenia (ScZ). The current study tested the effects of ketamine, a dissociative anesthetic and NMDA-R antagonist, on resting-state activity recorded with magnetoencephalography (MEG) in healthy volunteers. In a single-blind cross-over design, each participant (n = 12) received, on 2 different sessions, a subanesthetic dose of S-ketamine (0.006 mg/Kg) and saline injection. MEG-data were analyzed at sensor- and source-level in the beta (13-30 Hz) and gamma (30-90 Hz) frequency ranges. In addition, connectivity analysis at source-level was performed using transfer entropy (TE). Ketamine increased gamma-power while beta-band activity was decreased. Specifically, elevated 30-90 Hz activity was pronounced in subcortical (thalamus and hippocampus) and cortical (frontal and temporal cortex) regions, whilst reductions in beta-band power were localized to the precuneus, cerebellum, anterior cingulate, temporal and visual cortex. TE analysis demonstrated increased information transfer in a thalamo-cortical network after ketamine administration. The findings are consistent with the pronounced dysregulation of high-frequency oscillations following the inhibition of NMDA-R in animal models of ScZ as well as with evidence from electroencephalogram-data in ScZ-patients and increased functional connectivity during early illness stages. Moreover, our data highlight the potential contribution of thalamo-cortical connectivity patterns towards ketamine-induced neuronal dysregulation, which may be relevant for the understanding of ScZ as a disorder of disinhibition of neural circuits. PMID:25987642

  11. Experimental and theoretical charge-density analysis of 1,4-bis(5-hexyl-2-thienyl)butane-1,4-dione: applications of a virtual-atom model.

    Science.gov (United States)

    Ahmed, Maqsood; Nassour, Ayoub; Noureen, Sajida; Lecomte, Claude; Jelsch, Christian

    2016-02-01

    The experimental and theoretical charge densities of 1,4-bis(5-hexyl-2-thienyl)butane-1,4-dione, a precursor in the synthesis of thiophene-based semiconductors and organic solar cells, are presented. A dummy bond charges spherical atom model is applied besides the multipolar atom model. The results show that the dummy bond charges model is accurate enough to calculate electrostatic-derived properties which are comparable with those obtained by the multipolar atom model. The refinement statistics and the residual electron density values are found to be intermediate between the independent atom and the multipolar formalisms. PMID:26830798

  12. Application of high-quality SiO2 grown by multipolar ECR source to Si/SiGe MISFET

    Science.gov (United States)

    Sung, K. T.; Li, W. Q.; Li, S. H.; Pang, S. W.; Bhattacharya, P. K.

    1993-01-01

    A 5 nm-thick SiO2 gate was grown on an Si(p+)/Si(0.8)Ge(0.2) modulation-doped heterostructure at 26 C with an oxygen plasma generated by a multipolar electron cyclotron resonance source. The ultrathin oxide has breakdown field above 12 MV/cm and fixed charge density about 3 x 10 exp 10/sq cm. Leakage current as low as 1/micro-A was obtained with the gate biased at 4 V. The MISFET with 0.25 x 25 sq m gate shows maximum drain current of 41.6 mA/mm and peak transconductance of 21 mS/mm.

  13. Multipolar theory of blackbody radiation shift of atomic energy levels and its implications for optical lattice clocks

    International Nuclear Information System (INIS)

    Blackbody radiation (BBR) shifts of the 3P0-1S0 clock transition in the divalent atoms Mg, Ca, Sr, and Yb are evaluated. The dominant electric-dipole contributions are computed using accurate relativistic many-body techniques of atomic structure. At room temperatures, the resulting uncertainties in the E1 BBR shifts are large and substantially affect the projected 10-18 fractional accuracy of the optical-lattice-based clocks. A peculiarity of these clocks is that the characteristic BBR wavelength is comparable to the 3P fine-structure intervals. To evaluate relevant M1 and E2 contributions, a theory of multipolar BBR shifts is developed. The resulting corrections, although presently masked by the uncertainties in the E1 contribution, are required at the 10-18 accuracy goal

  14. Does IQ affect the functional brain network involved in pseudoword reading in students with reading disability? A magnetoencephalography study

    Directory of Open Access Journals (Sweden)

    Panagiotis G Simos

    2014-01-01

    Full Text Available The study examined whether individual differences in performance and verbal IQ affect the profiles of reading-related regional brain activation in 127 students experiencing reading difficulties and typical readers. Using magnetoencephalography in a pseudoword read-aloud task, we compared brain activation profiles of students experiencing word-level reading difficulties who did (n=29 or did not (n=36 meet the IQ-reading achievement discrepancy criterion. Typical readers assigned to a lower-IQ (n=18 or a higher IQ (n=44 subgroup served as controls. Minimum norm estimates of regional cortical activity revealed that the degree of hypoactivation in the left superior temporal and supramarginal gyri in both RD subgroups was not affected by IQ. Moreover, IQ did not moderate the positive association between degree of activation in the left fusiform gyrus and phonological decoding ability. We did find, however, that the hypoactivation of the left pars opercularis in RD was restricted to lower-IQ participants. In accordance with previous morphometric and fMRI studies, degree of activity in inferior frontal and inferior parietal regions correlated with IQ across reading ability subgroups. Results are consistent with current views questioning the relevance of IQ measures and IQ-discrepancy criteria in the diagnosis of dyslexia.

  15. Does IQ affect the functional brain network involved in pseudoword reading in students with reading disability? A magnetoencephalography study

    Science.gov (United States)

    Simos, Panagiotis G.; Rezaie, Roozbeh; Papanicolaou, Andrew C.; Fletcher, Jack M.

    2014-01-01

    The study examined whether individual differences in performance and verbal IQ affect the profiles of reading-related regional brain activation in 127 students experiencing reading difficulties and typical readers. Using magnetoencephalography in a pseudoword read-aloud task, we compared brain activation profiles of students experiencing word-level reading difficulties who did (n = 29) or did not (n = 36) meet the IQ-reading achievement discrepancy criterion. Typical readers assigned to a lower-IQ (n = 18) or a higher IQ (n = 44) subgroup served as controls. Minimum norm estimates of regional cortical activity revealed that the degree of hypoactivation in the left superior temporal and supramarginal gyri in both RD subgroups was not affected by IQ. Moreover, IQ did not moderate the positive association between degree of activation in the left fusiform gyrus and phonological decoding ability. We did find, however, that the hypoactivation of the left pars opercularis in RD was restricted to lower-IQ participants. In accordance with previous morphometric and fMRI studies, degree of activity in inferior frontal, and inferior parietal regions correlated with IQ across reading ability subgroups. Results are consistent with current views questioning the relevance of IQ-discrepancy criteria in the diagnosis of dyslexia. PMID:24409136

  16. A multicenter study of the early detection of synaptic dysfunction in Mild Cognitive Impairment using Magnetoencephalography-derived functional connectivity

    Directory of Open Access Journals (Sweden)

    Fernando Maestú, PhD

    2015-01-01

    Full Text Available Synaptic disruption is an early pathological sign of the neurodegeneration of Dementia of the Alzheimer's type (DAT. The changes in network synchronization are evident in patients with Mild Cognitive Impairment (MCI at the group level, but there are very few Magnetoencephalography (MEG studies regarding discrimination at the individual level. In an international multicenter study, we used MEG and functional connectivity metrics to discriminate MCI from normal aging at the individual person level. A labeled sample of features (links that distinguished MCI patients from controls in a training dataset was used to classify MCI subjects in two testing datasets from four other MEG centers. We identified a pattern of neuronal hypersynchronization in MCI, in which the features that best discriminated MCI were fronto-parietal and interhemispheric links. The hypersynchronization pattern found in the MCI patients was stable across the five different centers, and may be considered an early sign of synaptic disruption and a possible preclinical biomarker for MCI/DAT.

  17. A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1.

    Science.gov (United States)

    Wang, Jingnan; Li, Jianfeng; Santana-Santos, Lucas; Shuda, Masahiro; Sobol, Robert W; Van Houten, Bennett; Qian, Wei

    2015-02-01

    Traditional antimitotic drugs for cancer chemotherapy often have undesired toxicities to healthy tissues, limiting their clinical application. Developing novel agents that specifically target tumor cell mitosis is needed to minimize the toxicity and improve the efficacy of this class of anticancer drugs. We discovered that mdivi-1 (mitochondrial division inhibitor-1), which was originally reported as an inhibitor of mitochondrial fission protein Drp1, specifically disrupts M phase cell cycle progression only in human tumor cells, but not in non-transformed fibroblasts or epithelial cells. The antimitotic effect of mdivi-1 is Drp1 independent, as mdivi-1 induces M phase abnormalities in both Drp1 wild-type and Drp1 knockout SV40-immortalized/transformed MEF cells. We also identified that the tumor transformation process required for the antimitotic effect of mdivi-1 is downstream of SV40 large T and small t antigens, but not hTERT-mediated immortalization. Mdivi-1 induces multipolar mitotic spindles in tumor cells regardless of their centrosome numbers. Acentrosomal spindle poles, which do not contain the bona-fide centrosome components ?-tubulin and centrin-2, were found to contribute to the spindle multipolarity induced by mdivi-1. Gene expression profiling revealed that the genes involved in oocyte meiosis and assembly of acentrosomal microtubules are highly expressed in tumor cells. We further identified that tumor cells have enhanced activity in the nucleation and assembly of acentrosomal kinetochore-attaching microtubules. Mdivi-1 inhibited the integration of acentrosomal microtubule-organizing centers into centrosomal asters, resulting in the development of acentrosomal mitotic spindles preferentially in tumor cells. The formation of multipolar acentrosomal spindles leads to gross genome instability and Bax/Bak-dependent apoptosis. Taken together, our studies indicate that inducing multipolar spindles composing of acentrosomal poles in mitosis could achieve tumor-specific antimitotic effect, and mdivi-1 thus represents a novel class of compounds as acentrosomal spindle inducers (ASI). PMID:25458053

  18. Establishment of M1 multipolarity of a 6.5 mu_N^2 resonance in 172-Yb at E_gamma=3.3 MeV

    OpenAIRE

    A. Schiller; Voinov, A.; Algin, E.; J. A. Becker; Bernstein, L. A.; Garrett, P. E.; Guttormsen, M.; Nelson, R. O.; Rekstad, J.; Siem, S.

    2004-01-01

    Two-step-cascade spectra in 172-Yb have been measured after thermal neutron capture. They are compared to calculations based on experimental values of the level density and radiative strength function (RSF) obtained from the 173-Yb(3-He,alpha gamma)172-Yb reaction. The multipolarity of a 6.5(15) mu_N^2 resonance at E_gamma=3.3(1) MeV in the RSF is determined to be M1 by this comparison.

  19. Delocalization of the microtubule motor Dynein from mitotic spindles by the human papillomavirus E7 oncoprotein is not sufficient for induction of multipolar mitoses.

    Science.gov (United States)

    Nguyen, Christine L; McLaughlin-Drubin, Margaret E; Münger, Karl

    2008-11-01

    Dynein is a minus end-directed microtubule motor that transports numerous cargoes throughout the cell. During mitosis, dynein motor activity is necessary for the positioning of spindle microtubules and has also been implicated in inactivating the spindle assembly checkpoint. Mutations in dynein motor and/or accessory proteins are associated with human disease, including cancer, and the delocalization of dynein from mitotic spindles has been correlated with an increased incidence of multipolar spindle formation in some cancer cells that contain supernumerary centrosomes. The high-risk human papillomavirus type 16 (HPV16) E7 oncoprotein induces centrosome overduplication and has been shown to cause multipolar mitotic spindle formation, a diagnostic hallmark of HPV-associated neoplasias. Here, we show that HPV16 E7 expression leads to an increased population of mitotic cells with dynein delocalized from the mitotic spindle. This function maps to sequences of HPV16 E7 that are distinct from the region necessary for centrosome overduplication. However, contrary to previous reports, we provide evidence that dynein delocalization by HPV16 E7 is neither necessary nor sufficient to cause the formation of multipolar mitoses. PMID:18974113

  20. Discrimination of coastal wetland environments in the Amazon region based on multi-polarized L-band airborne Synthetic Aperture Radar imagery

    Science.gov (United States)

    Souza-Filho, Pedro Walfir M.; Paradella, Waldir R.; Rodrigues, Suzan W. P.; Costa, Francisco R.; Mura, José C.; Gonçalves, Fabrício D.

    2011-11-01

    This study assessed the use of multi-polarized L-band images for the identification of coastal wetland environments in the Amazon coast region of northern Brazil. Data were acquired with a SAR R99B sensor from the Amazon Surveillance System (SIVAM) on board a Brazilian Air Force jet. Flights took place in the framework of the 2005 MAPSAR simulation campaign, a German-Brazilian feasibility study focusing on a L-band SAR satellite. Information retrieval was based on the recognition of the interaction between a radar signal and shallow-water morphology in intertidal areas, coastal dunes, mangroves, marshes and the coastal plateau. Regarding the performance of polarizations, VV was superior for recognizing intertidal area morphology under low spring tide conditions; HH for mapping coastal environments covered with forest and scrub vegetation such as mangrove and vegetated dunes, and HV was suitable for distinguishing transition zones between mangroves and coastal plateau. The statistical results for the classification maps expressed by kappa index and general accuracy were 83.3% and 0.734 for the multi-polarized color composition (R-HH, G-HV, B-VV), 80.7% and 0.694% for HH, 79.7% and 0.673% for VV, and 77.9% and 0.645% for HV amplitude image. The results indicate that use of multi-polarized L-band SAR is a valuable source of information aiming at the identification and discrimination of distinct geomorphic targets in tropical wetlands.

  1. Crisis del lóbulo temporal registrada mediante magnetoencefalografía: caso clínico Temporal lobe seizure recorded by magnetoencephalography: case report

    Directory of Open Access Journals (Sweden)

    Carlos Amo

    2004-09-01

    Full Text Available La localización del inicio de las crisis es un factor importante para la evaluación prequirúrgica de la epilepsia. En este trabajo se describe la localización del inicio de una crisis registrada mediante magnetoencefalografía (MEG en un niño de 12 años que presenta crisis parciales complejas farmacorresistentes. La RM muestra una lesión de 20mm de diámetro en el hipocampo izquierdo. EEG de superficie con ondas theta temporales izquierdas. Registro MEG interictal con punta-onda aislada posterior e inferior a la lesión de la RM. Registro MEG ictal con punta-onda (2 Hz. La localización de los dipolos indica el inicio de la crisis en la circunvolución temporal inferior en la misma localización que la actividad interictal MEG. Esta actividad ictal se propaga bilateralmente a áreas frontales. El registro corticográfico intraquirúrgico confirma los resultados de la localización interictal mediante MEG.Ictal onset localization is a important factor in presurgical evaluation of epilepsy. This paper describes the localization of a seizure onset recorded by magnetoencephalography (MEG from a 12-year-old male patient who suffered from complex partial drug-resistant seizures. MRI revealed a 20mm diameter lesion located in left hippocampus. Scalp EEG showed left temporal theta waves. Interictal MEG registrations detected isolated spike-wave activity posterior and inferior to the MRI lesion. Ictal MEG showed continuous spike-wave activity (2 Hz. Dipole localization sited seizure onset in the inferior left temporal gyrus, the same localization of the interictal MEG activity. This ictal activity spreads bilaterally to frontal areas. Intrasurgical electrocorticography recording confirmed interictal MEG results.

  2. Crisis del lóbulo temporal registrada mediante magnetoencefalografía: caso clínico / Temporal lobe seizure recorded by magnetoencephalography: case report

    Scientific Electronic Library Online (English)

    Carlos, Amo; Marta, Santiuste; Fernando, Maestú; Alberto, Fernández; Renata, Egatz; Mercedes, González-Hidalgo; Cristóbal, Saldaña; Antonio, Sáiz; Tomás, Ortiz.

    2004-09-01

    Full Text Available La localización del inicio de las crisis es un factor importante para la evaluación prequirúrgica de la epilepsia. En este trabajo se describe la localización del inicio de una crisis registrada mediante magnetoencefalografía (MEG) en un niño de 12 años que presenta crisis parciales complejas farmac [...] orresistentes. La RM muestra una lesión de 20mm de diámetro en el hipocampo izquierdo. EEG de superficie con ondas theta temporales izquierdas. Registro MEG interictal con punta-onda aislada posterior e inferior a la lesión de la RM. Registro MEG ictal con punta-onda (2 Hz). La localización de los dipolos indica el inicio de la crisis en la circunvolución temporal inferior en la misma localización que la actividad interictal MEG. Esta actividad ictal se propaga bilateralmente a áreas frontales. El registro corticográfico intraquirúrgico confirma los resultados de la localización interictal mediante MEG. Abstract in english Ictal onset localization is a important factor in presurgical evaluation of epilepsy. This paper describes the localization of a seizure onset recorded by magnetoencephalography (MEG) from a 12-year-old male patient who suffered from complex partial drug-resistant seizures. MRI revealed a 20mm diame [...] ter lesion located in left hippocampus. Scalp EEG showed left temporal theta waves. Interictal MEG registrations detected isolated spike-wave activity posterior and inferior to the MRI lesion. Ictal MEG showed continuous spike-wave activity (2 Hz). Dipole localization sited seizure onset in the inferior left temporal gyrus, the same localization of the interictal MEG activity. This ictal activity spreads bilaterally to frontal areas. Intrasurgical electrocorticography recording confirmed interictal MEG results.

  3. High rate sputtering for Ni films by an rf-dc coupled magnetron sputtering system with multipolar magnetic plasma confinement

    International Nuclear Information System (INIS)

    Ni films were prepared by an rf-dc coupled magnetron sputtering with multipolar magnetic plasma confinement (MMPC) at the low pressure of 6.7x10-2 Pa and at the long distance of 120 mm, when permanent magnets were placed around a nickel target (200 mm ?, 5 mm thick) outside the chamber. When rf power and dc bias voltages were applied simultaneously to the target, the deposition rate of the Ni films significantly increased with the target dc bias voltage (VT). The highest value of the deposition rate was about 250 nm/min at VT=-820 V. The high rate sputtering for Ni films was possible at the low Ar gas pressure of 6.7x10-2 Pa. The resistivity for all the films deposited at different dc bias voltages was 7.1-8.2 ?? cm whose value was close to the bulk value. It is shown that the sputtering system with MMPC has some advantages in comparison with conventional magnetron sputtering, such as high deposition rate, plasma discharge stability, and the preparation of high quality magnetic thin films

  4. Collisional diffusion of a plasma in multipolar and picket fence devices

    International Nuclear Information System (INIS)

    A collisional diffusion model of a low-#betta# plasma in a two-dimensional magnetic field is worked out under the assumption of joint diffusion of electrons and ions in the plane of the magnetic field. This model is applied to multidipole and picket fence discharges; density and potential profile are computed. The main features observed experimentally are in qualitative agreement with this computation: a leak width proportional to the hybrid gyroradius and the existence of potential hills between the cusps and poor plasma confinement

  5. A Rússia na ordem mundial: com o Ocidente, com o Oriente ou um pólo autônomo em um mundo multipolar?

    Scientific Electronic Library Online (English)

    Alexander, Zhebit.

    2003-06-01

    Full Text Available O artigo persegue o objetivo de definir o lugar e o papel da Rússia nas relações internacionais contemporâneas nos últimos anos. Ao se debruçar sobre o dilema tradicional da política externa russa - Ocidentalismo versus Orientalismo - o autor analisa o cenário de multipolaridade defendido pela nova [...] concepção da política externa russa e o relaciona com a fase do pragmatismo e do multilateralismo que caracteriza a atuação internacional da Rússia de Putin, fazendo considerações, decorrentes do impacto dos ataques terroristas aos Estados Unidos em 11 de setembro de 2001 sobre a política externa russa. A atitude pragmática e a natureza multivetorial da política externa russa contribuem, segundo o autor, para o fortalecimento das posições internacionais da Rússia em comparação com a perda ou a natureza incerta das alianças e dos relacionamentos do período da transição pós-soviética. Abstract in english The article pursues the purpose to place Russia and its politics within the context of today's international relations. While discussing the traditional dilemma of the Russian foreign politics - Occidentalism versus Orientalism - the author analyses the scenario of multipolarity, backed up by the ne [...] w Russian foreign policy concept. Hence it is related to the pragmatism and the multilateralism of the international posture of Putin's Russia, the author makes several considerations, which follow from the impact of the September 11th, 2001, terrorist attacks on the United States of America with regard to Russia's foreign policy. The pragmatic attitude and the multi-axis nature of the Russian foreign policy nowadays contribute, according to the author, to strengthen Russia's international background in comparison with the loss or the uncertain nature of alliances and relationships of the post-Soviet transition period.

  6. A Rússia na ordem mundial: com o Ocidente, com o Oriente ou um pólo autônomo em um mundo multipolar?

    Directory of Open Access Journals (Sweden)

    Alexander Zhebit

    2003-06-01

    Full Text Available O artigo persegue o objetivo de definir o lugar e o papel da Rússia nas relações internacionais contemporâneas nos últimos anos. Ao se debruçar sobre o dilema tradicional da política externa russa - Ocidentalismo versus Orientalismo - o autor analisa o cenário de multipolaridade defendido pela nova concepção da política externa russa e o relaciona com a fase do pragmatismo e do multilateralismo que caracteriza a atuação internacional da Rússia de Putin, fazendo considerações, decorrentes do impacto dos ataques terroristas aos Estados Unidos em 11 de setembro de 2001 sobre a política externa russa. A atitude pragmática e a natureza multivetorial da política externa russa contribuem, segundo o autor, para o fortalecimento das posições internacionais da Rússia em comparação com a perda ou a natureza incerta das alianças e dos relacionamentos do período da transição pós-soviética.The article pursues the purpose to place Russia and its politics within the context of today's international relations. While discussing the traditional dilemma of the Russian foreign politics - Occidentalism versus Orientalism - the author analyses the scenario of multipolarity, backed up by the new Russian foreign policy concept. Hence it is related to the pragmatism and the multilateralism of the international posture of Putin's Russia, the author makes several considerations, which follow from the impact of the September 11th, 2001, terrorist attacks on the United States of America with regard to Russia's foreign policy. The pragmatic attitude and the multi-axis nature of the Russian foreign policy nowadays contribute, according to the author, to strengthen Russia's international background in comparison with the loss or the uncertain nature of alliances and relationships of the post-Soviet transition period.

  7. Multipolar SPM machines for direct drive application: a comprehensive design approach

    OpenAIRE

    Boazzo, Barbara; Pellegrino, Gian-Mario Luigi; Vagati, Alfredo

    2012-01-01

    A closed-form, per-unit formulation is proposed, for the design of surface mounted permanent magnet motors with high number of poles. The model evaluates the shear stress, the power factor and the specific Joule loss as the indicators of the machine performance, and demonstrates that this is determined by the correct choice of a very limited set of key-geometrical parameters. The design criteria are described analytically and then applied to example designs, FEA validated. Distributed- and co...

  8. Statistical contribution in the giant multipolar resonance decay in hevay nuclei

    International Nuclear Information System (INIS)

    Statistical calculations are made for the decay in the electric monopole giant resonance in 208Pb and electric dipole giant resonance in 209Bi, using the Hauser-Feshbach formalism. Calculations are done using the experimental energy levels of the corresponding residual nuclei. The particle-vibrator model is used for those experimental levels without spin and parity determination. The influence of different parametrizations of the optical potential in the statistical calculation result is also studied. (L.C.)

  9. Realistic sampling of amino acid geometries for a multipolar polarizable force field.

    Science.gov (United States)

    Hughes, Timothy J; Cardamone, Salvatore; Popelier, Paul L A

    2015-09-15

    The Quantum Chemical Topological Force Field (QCTFF) uses the machine learning method kriging to map atomic multipole moments to the coordinates of all atoms in the molecular system. It is important that kriging operates on relevant and realistic training sets of molecular geometries. Therefore, we sampled single amino acid geometries directly from protein crystal structures stored in the Protein Databank (PDB). This sampling enhances the conformational realism (in terms of dihedral angles) of the training geometries. However, these geometries can be fraught with inaccurate bond lengths and valence angles due to artefacts of the refinement process of the X-ray diffraction patterns, combined with experimentally invisible hydrogen atoms. This is why we developed a hybrid PDB/nonstationary normal modes (NM) sampling approach called PDB/NM. This method is superior over standard NM sampling, which captures only geometries optimized from the stationary points of single amino acids in the gas phase. Indeed, PDB/NM combines the sampling of relevant dihedral angles with chemically correct local geometries. Geometries sampled using PDB/NM were used to build kriging models for alanine and lysine, and their prediction accuracy was compared to models built from geometries sampled from three other sampling approaches. Bond length variation, as opposed to variation in dihedral angles, puts pressure on prediction accuracy, potentially lowering it. Hence, the larger coverage of dihedral angles of the PDB/NM method does not deteriorate the predictive accuracy of kriging models, compared to the NM sampling around local energetic minima used so far in the development of QCTFF. PMID:26235784

  10. Experimental investigation of microwave interaction with magnetoplasma in miniature multipolar configuration using impedance measurements

    International Nuclear Information System (INIS)

    A miniature microwave plasma source employing both radial and axial magnetic fields for plasma confinement has been developed for micro-propulsion applications. Plasma is initiated by launching microwaves via a short monopole antenna to circumvent geometrical cutoff limitations. The amplitude and phase of the forward and reflected microwave power is measured to obtain the complex reflection coefficient from which the equivalent impedance of the plasma source is determined. Effect of critical plasma density condition is reflected in the measurements and provides insight into the working of the miniature plasma source. A basic impedance calculation model is developed to help in understanding the experimental observations. From experiment and theory, it is seen that the equivalent impedance magnitude is controlled by the coaxial discharge boundary conditions, and the phase is influenced primarily by the plasma immersed antenna impedance

  11. Experimental investigation of microwave interaction with magnetoplasma in miniature multipolar configuration using impedance measurements

    Energy Technology Data Exchange (ETDEWEB)

    Dey, Indranuj, E-mail: indranuj@aees.kyushu-u.ac.jp; Toyoda, Yuji; Yamamoto, Naoji; Nakashima, Hideki [Department of Advanced Energy Engineering Science, Kyushu University, Kasuga 816-8580 (Japan)

    2014-09-15

    A miniature microwave plasma source employing both radial and axial magnetic fields for plasma confinement has been developed for micro-propulsion applications. Plasma is initiated by launching microwaves via a short monopole antenna to circumvent geometrical cutoff limitations. The amplitude and phase of the forward and reflected microwave power is measured to obtain the complex reflection coefficient from which the equivalent impedance of the plasma source is determined. Effect of critical plasma density condition is reflected in the measurements and provides insight into the working of the miniature plasma source. A basic impedance calculation model is developed to help in understanding the experimental observations. From experiment and theory, it is seen that the equivalent impedance magnitude is controlled by the coaxial discharge boundary conditions, and the phase is influenced primarily by the plasma immersed antenna impedance.

  12. Multipolar Force Fields and Their Effects on Solvent Dynamics around Simple Solutes

    DEFF Research Database (Denmark)

    Jakobsen, Sofie; Bereau, Tristan

    2015-01-01

    The performance of multipole (MTP) and point charge (PC) force fields in classical molecular dynamics (MD) simulations of condensed-phase systems for both equilibrium and dynamical quantities is compared. MTP electrostatics provides an improved description of the anisotropic electrostatic potential, which is especially important to describe key, challenging interactions, such as lone pairs, ?-interactions, and hydrogen bonds. These chemical environments are probed by focusing on the hydration properties of two molecules: N-methylacetamide and phenyl bromide. Both, equilibrium and dynamical, quantities are affected by the quality of the electrostatic model. The alteration of the first solvation shell in MTP simulations is validated by comparing with lifetimes and correlation times of solute–solvent interactions from experiment. The improved dynamical behavior found in the MTP simulations—observed for molecules parametrized using very different protocols—suggests that a systematic improvement of both equilibrium and dynamical quantities when using MTP electrostatics is possible.

  13. Magnetar Giant Flares in Multipolar Magnetic Fields --- I. Fully and Partially Open Eruptions of Flux Ropes

    CERN Document Server

    Huang, Lei

    2014-01-01

    We propose a catastrophic eruption model for magnetar's enormous energy release during giant flares, in which a toroidal and helically twisted flux rope is embedded within a force-free magnetosphere. The flux rope stays in stable equilibrium states initially and evolves quasi-statically. Upon the loss of equilibrium point is reached, the flux rope cannot sustain the stable equilibrium states and erupts catastrophically. During the process, the magnetic energy stored in the magnetosphere is rapidly released as the result of destabilization of global magnetic topology. The magnetospheric energy that could be accumulated is of vital importance for the outbursts of magnetars. We carefully establish the fully open fields and partially open fields for various boundary conditions at the magnetar surface and study the relevant energy thresholds. By investigating the magnetic energy accumulated at the critical catastrophic point, we find that it is possible to drive fully open eruptions for dipole dominated background...

  14. Quantifying the Sensitivity of Multipolar (Dipolar, Quadrupolar, and Octapolar) Surface Plasmon Resonances in Silver Nanoparticles: The Effect of Size, Composition, and Surface Coating.

    Science.gov (United States)

    Bastús, Neus G; Piella, Jordi; Puntes, Víctor

    2016-01-12

    The effect of composition, size, and surface coating on the sensitivity of localized multipolar surface plasmon resonances has been spectroscopically investigated in high-quality silver colloidal solutions with precisely controlled sizes from 10 to 220 nm and well-defined surface chemistry. Surface plasmon resonance modes have been intensively characterized, identifying the size-dependence of dipolar, quadrupolar, and octapolar modes. Modifications of the NP's surface chemistry revealed the higher sensitivity of large sizes, long molecules, thiol groups, and low-order resonance modes. We also extend this study to gold nanoparticles, aiming to compare the sensitivity of both materials, quantifying the higher sensitivity of silver. PMID:26649600

  15. The Fate of Sub-micron Circumplanetary Dust Grains II: Multipolar Fields

    CERN Document Server

    Jontof-Hutter, Daniel

    2012-01-01

    We study the radial and vertical stability of dust grains launched with all charge-to-mass ratios at arbitrary distances from rotating planets with complex magnetic fields. We show that the aligned dipole magnetic field model analyzed by Jontof-Hutter and Hamilton (2012) is an excellent approximation in most cases, but that fundamentally new physics arises with the inclusion of non-axisymmetric magnetic field terms. In particular, large numbers of distant negatively-charged dust grains, stable in a magnetic dipole, can be driven to escape by a more complex field. We trace the origin of the instability to overlapping Lorentz resonances which are extremely powerful when the gravitational and electromagnetic forces on a dust grain are comparable. These resonances enable a dust grain to tap the spin energy of the planet to power its escape. We also explore the relatively minor influence of different launch speeds and the far more important effects of variable grain charge. Only the latter are capable of significa...

  16. Interplay of interchain interactions and exchange anisotropy: Stability and fragility of multipolar states in spin-1/2 quasi-one-dimensional frustrated helimagnets

    Science.gov (United States)

    Nishimoto, Satoshi; Drechsler, Stefan-Ludwig; Kuzian, Roman; Richter, Johannes; van den Brink, Jeroen

    2015-12-01

    We quantify the stability of the formation of multipolar states against always present interchain couplings in quasi-one-dimensional spin-1/2 chain systems with a frustrating in-chain J1-J2 exchange, including parameter regimes that are of direct relevance to many edge-shared cuprate spin-chain compounds. Three representative types of antiferromagnetic interchain coupling and the presence of uniaxial exchange anisotropy are considered. The magnetic phase diagrams are determined by density matrix renormalization group calculations and completed by very accurate analytic and numerical results for the nematic and the dipolar phases employing the hard-core-boson approach. We establish that a sizable interchain coupling has a strong influence on the possible instability of multipolar phases at high magnetic fields in the vicinity of the saturation fields in favor of the usual dipolar one-magnon phase. Moreover, skew interchain couplings strongly affect the pitch of spiral states. Our theoretical results bring to the fore candidate materials close to quantum nematic/triatic ordering.

  17. A program for calculating gamma-gamma directional correlation coefficients and angular distribution coefficients for gamma rays of mixed multipolarities from partially aligned nuclei

    International Nuclear Information System (INIS)

    Conservation of angular momentum governs the multipolarity of electromagnetic transitions between nuclear excited states. In certain cases a mixture of two multipolarities may occur in a single transition. The amount of mixing, i.e. the mixing ratio, is determined by the structure of the nuclear levels involved. The most probable mixing ratio can be determined by accurately measuring the directional correlation between two transitions or the angular distribution of a gamma ray with respect to a beam of charged particles which partially aligns the nucleus. The program ANGCOR, catalogue number ABPG, for analyzing gamma-gamma directional correlations has been modified to include analysis of the angular distribution data. The program has two modes of operation. In mode I or data analysis mode, directional correlation or distribution coefficients Asub(K) are fit to the experimental data by the method of least-squares with second- and fourth-order Legendre polynomials having only even terms. Mode II, the data simulation mode, calculates a set of directional correlation coefficients either from spins and two mixing ratios or from a mixing ratio and a value of sigma corrects for solid angle, and calculates a set of angular correlation data normalized to A0 = 10 000. These simulated data are then entered in mode I and result in a similar output. In effect, the second mode allows the user to test the program. (Auth.)

  18. Multipolarity or cosmopolitanism?

    DEFF Research Database (Denmark)

    Hansen, Allan Dreyer

    Mouffe are flawed. As she puts it, if a cosmopolitan democracy “was ever realized, it could only signify the world hegemony of a dominant power that would have been able to impose its conception of the world on the entire planet and which, identifying its interests with those of humanity, would treat any...... hegemony – as developed by herself and Laclau in Hegemony and Socialist Strategy, (Laclau and Mouffe,1985), precisely allows us to see the distance between universal values, such as freedom and equality for all, and their actual interpretation and use. The fact that the West are using democracy and human...

  19. Anti-Stress, Behavioural and Magnetoencephalography Effects of an l-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial

    Directory of Open Access Journals (Sweden)

    David J. White

    2016-01-01

    Full Text Available l-theanine (?-glutamylethylamide is an amino acid found primarily in the green tea plant. This study explored the effects of an l-theanine-based nutrient drink on mood responses to a cognitive stressor. Additional measures included an assessment of cognitive performance and resting state alpha oscillatory activity using magnetoencephalography (MEG. Thirty-four healthy adults aged 18–40 participated in this double-blind, placebo-controlled, balanced crossover study. The primary outcome measure, subjective stress response to a multitasking cognitive stressor, was significantly reduced one hour after administration of the l-theanine drink when compared to placebo. The salivary cortisol response to the stressor was reduced three hours post-dose following active treatment. No treatment-related cognitive performance changes were observed. Resting state alpha oscillatory activity was significantly greater in posterior MEG sensors after active treatment compared to placebo two hours post-dose; however, this effect was only apparent for those higher in trait anxiety. This change in resting state alpha oscillatory activity was not correlated with the change in subjective stress response or the cortisol response, suggesting further research is required to assess the functional relevance of these treatment-related changes in resting alpha activity. These findings further support the anti-stress effects of l-theanine.

  20. Magnetoencephalography Slow-Wave Detection in Patients with Mild Traumatic Brain Injury and Ongoing Symptoms Correlated with Long-Term Neuropsychological Outcome.

    Science.gov (United States)

    Robb Swan, Ashley; Nichols, Sharon; Drake, Angela; Angeles, AnneMarie; Diwakar, Mithun; Song, Tao; Lee, Roland R; Huang, Ming-Xiong

    2015-10-01

    Mild traumatic brain injury (mTBI) is common in the United States, accounting for as many as 75-80% of all TBIs. It is recognized as a significant public health concern, but there are ongoing controversies regarding the etiology of persistent symptoms post-mTBI. This constellation of nonspecific symptoms is referred to as postconcussive syndrome (PCS). The present study combined results from magnetoencephalography (MEG) and cognitive assessment to examine group differences and relationships between brain activity and cognitive performance in 31 military and civilian individuals with a history of mTBI+PCS and 33 matched healthy control subjects. An operator-free analysis was used for MEG data to increase reliability of the technique. Subjects completed a comprehensive neuropsychological assessment, and measures of abnormal slow-wave activity from MEG were collected. Results demonstrated significant group differences on measures of executive functioning and processing speed. In addition, significant correlations between slow-wave activity on MEG and patterns of cognitive functioning were found in cortical areas, consistent with cognitive impairments on exams. Results provide more objective evidence that there may be subtle changes to the neurobiological integrity of the brain that can be detected by MEG. Further, these findings suggest that these abnormalities are associated with cognitive outcomes and may account, at least in part, for long-term PCS in those who have sustained an mTBI. PMID:25808909

  1. Detection and Magnetic Source Imaging of Fast Oscillations (40-160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients.

    Science.gov (United States)

    von Ellenrieder, Nicolás; Pellegrino, Giovanni; Hedrich, Tanguy; Gotman, Jean; Lina, Jean-Marc; Grova, Christophe; Kobayashi, Eliane

    2016-03-01

    We present a framework to detect fast oscillations (FOs) in magnetoencephalography (MEG) and to perform magnetic source imaging (MSI) to determine the location and extent of their generators in the cortex. FOs can be of physiologic origin associated to sensory processing and memory consolidation. In epilepsy, FOs are of pathologic origin and biomarkers of the epileptogenic zone. Seventeen patients with focal epilepsy previously confirmed with identified FOs in scalp electroencephalography (EEG) were evaluated. To handle data deriving from large number of sensors (275 axial gradiometers) we used an automatic detector with high sensitivity. False positives were discarded by two human experts. MSI of the FOs was performed with the wavelet based maximum entropy on the mean method. We found FOs in 11/17 patients, in only one patient the channel with highest FO rate was not concordant with the epileptogenic region and might correspond to physiologic oscillations. MEG FOs rates were very low: 0.02-4.55 per minute. Compared to scalp EEG, detection sensitivity was lower, but the specificity higher in MEG. MSI of FOs showed concordance or partial concordance with proven generators of seizures and epileptiform activity in 10/11 patients. We have validated the proposed framework for the non-invasive study of FOs with MEG. The excellent overall concordance with other clinical gold standard evaluation tools indicates that MEG FOs can provide relevant information to guide implantation for intracranial EEG pre-surgical evaluation and for surgical treatment, and demonstrates the important added value of choosing appropriate FOs detection and source localization methods. PMID:26830767

  2. Dynamics of human cortical neurovascular coupling resolved in the millisecond range using combined dc-magnetoencephalography and time-resolved near-infrared spectroscopy

    Directory of Open Access Journals (Sweden)

    Stefanie Leistner

    2008-11-01

    Full Text Available Introduction: During the last decade, dc-magnetoencephalography (DC-MEG has been refined and allows to record cortical activity in the infraslow frequency range ( Methods: 12 healthy right-handed human subjects were studied. As a physiological activation paradigm a simple right finger movement task for 30 s periods, separated by 30 s rest periods, was used for a total of 30 min. Unmodulated DC-MEG (Berlin magnetically shielded room BMSR-2 and multichannel tr-NIRS using amagnetical optodes were recorded over the left motor cortex simultaneously with cardinal peripheral physiological signals, such as heart beat, respiration, and electromyographical activity (EMG for monitoring of the finger movements. Results: DC-fields and tr-NIRS parameters followed closely the 30 s motor task cycles. While the DC-MEG signals showed activation-related changes on the scale of 100 ms at the beginning of the finger movement sequence monitored by EMG, the change in the NIRS signals started on the scale of a few seconds. Discussion: The non-invasive 'dual' setup is capable to characterize simultaneously the complementary aspects of the 'hemodynamic inverse problem', i.e., the coupling of neuronal and vascular/metabolic signals with a time resolution of milliseconds. Thereby, the vascular response showed a delay of maximum in the range of seconds. Significance: This 'dual' measuring technique provides a non-invasive recording tool to prove not only physiological but also pathophysiological cerebral coupling concepts in diverse diseases, e.g., in stroke, hypertension and Alzheimer's disease.

  3. Spectral power and functional connectivity changes during mindfulness meditation with eyes open: A magnetoencephalography (MEG) study in long-term meditators.

    Science.gov (United States)

    Wong, W P; Camfield, D A; Woods, W; Sarris, J; Pipingas, A

    2015-10-01

    Whilst a number of previous studies have been conducted in order to investigate functional brain changes associated with eyes-closed meditation techniques, there is a relative scarcity in the literature with regards to changes occurring during eyes-open meditation. The current project used magnetoencephalography (MEG) to investigate differences in spectral power and functional connectivity between 11 long-term mindfulness meditators (LTMMs) with >5 years of experience and 12 meditation-naïve control participants both during baseline eyes-open rest and eyes-open open-monitoring (OM) mindfulness meditation. During resting with eyes-open, prior to meditating, greater mean alpha power was observed for LTMMs in comparison to controls. However, during the course of OM meditation, a significantly greater increase in theta power was observed over a broad fronto-centro-parietal region for control participants in comparison to LTMMs. In contrast, whole-head mean connectivity was found to be significantly greater for long-term meditators in comparison to controls in the theta band both during rest as well as during meditation. Additionally, mean connectivity was significantly lower for long-term meditators in the low gamma band during rest and significantly lower in both low and high gamma bands during meditation; and the variance of low-gamma connectivity scores for long-term meditators was significantly decreased compared to the control group. The current study provides important new information as to the trait functional changes in brain activity associated with long-term mindfulness meditation, as well as the state changes specifically associated with eyes-open open monitoring meditation techniques. PMID:26166440

  4. Consistencia epistémica del síndrome de Dificultades del Aprendizaje: aportaciones de la magnetoencefalografía como técnica de neuroimagen funcional / Epistemics for Learning Disabilities: Contributions from Magnetoencephalography, a Functional Neuroimaging Tool

    Scientific Electronic Library Online (English)

    VÍCTOR, SANTIUSTE-BERMEJO; MARTA, SANTIUSTE-DÍAZ.

    2008-12-01

    Full Text Available El síndrome Dificultades del Aprendizaje (DA) fue descrito en 1963 por S. Kirk. Desde entonces, diversas escuelas en EE.UU., Canadá y España han afinado su concepto y clasificación. La UCM en España ha propuesto una definición descriptiva y totalizadora, y ha estudiado empíricamente distintas manife [...] staciones, intentando descubrir sus marcadores biológicos y las características neurológicas de sus principales manifestaciones (dislexia, discalculia, disortografia, TDA, TDAH, etc.). Se describen los hallazgos en DA a partir de estudios como la magnetoencefalografía (MEG), técnica inocua que recoge campos magnéticos generados naturalmente por el cerebro y analiza su distribución espacial para localizar los generadores neuronales responsables, proporcionando información simultánea sobre la estructura y la función cerebral en patrones de normalidad en el procesamiento cognitivo y patrones aberrantes propios de las particulares manifestaciones clínicas del síndrome DA. Abstract in english The syndrome known as Learning Disabilities (LD) was described by S. Kirk in 1963. From that point on, institutions from the US, Canada and Spain have engaged in refining the concept and classification of LDs. The Complutense University in Spain, has proposed a descriptive and all-embracing definiti [...] on, and has studied the different manifestations of LD, pursuing the description of biological markers and neurological features of LD’s main expressions: dyslexia, dyscalculia, dysorthographia, Attention Deficit and Hyperactivity Disorder -ADHD, and so forth. Findings in LD using functional neuroimaging techniques, namely Magnetoencephalography (MEG), are described. MEG is a non-invasive technique, which records magnetic fields naturally generated by the brain and their spatial distribution. It allows simultaneous functional and structural information. MEG is therefore used in the study of primary and superior cognitive functions, in surveillance of patterns of normal cognitive function and those specific to the different LD clinical manifestations.

  5. On the use of L-band multipolarization airborne SAR for surveys of crops, vineyards, and orchards in a California irrigated agricultural region

    Science.gov (United States)

    Paris, J. F.

    1985-01-01

    The airborne L-band synthetic aperture radar (SAR) collected multipolarization calibrated image data over an irrigated agricultural test site near Fresno, CA, on March 6, 1984. The conclusions of the study are as follows: (1) the effects of incidence angle on the measured backscattering coefficients could be removed by using a correction factor equal to the secant of the angle raised to the 1.4 power, (2) for this scene and time of year, the various polarization channels were highly correlated such that the use of more than one polarization added little to the ability of the radar to discriminate vegetation type or condition; the exception was barley which separated from vineyards only when a combination of like and cross polarization data were used (polarization was very useful for corn identification in fall crops), (3) an excellent separation between herbaceous vegetation (alfalfa, barley, and oats) or bare fields and trees in orchards existed in brightness was well correlated to alfalfa height or biomass, especially for the HH polarization combination, (5) vineyards exhibited a narrow range of brightnesses with no systematic effects of type or number of stakes nor of number of wires in the trellises nor of the size of the vines, (6) within the orchard classes, areal biomass characterized by basal area differences caused radar image brightness differences for small to medium trees but not for medium to large trees.

  6. Binary black hole coalescence in the extreme-mass-ratio limit: Testing and improving the effective-one-body multipolar waveform

    International Nuclear Information System (INIS)

    We discuss the properties of the effective-one-body (EOB) multipolar gravitational waveform emitted by nonspinning black-hole binaries of masses ? and M in the extreme-mass-ratio limit ?/M=?-4 rad and maintain then a remarkably accurate phase coherence during the long inspiral (?33 orbits), accumulating only about -2x10-3 rad until the last stable orbit, i.e. ??/??-5.95x10-6. We obtain such accuracy without calibrating the analytically resummed EOB waveform to numerical data, which indicates the aptitude of the EOB waveform for studies concerning the Laser Interferometer Space Antenna. We then improve the behavior of the EOB waveform around merger by introducing and tuning next-to-quasicircular corrections in both the gravitational wave amplitude and phase. For each multipole we tune only four next-to-quasicircular parameters by requiring compatibility between EOB and Regge-Wheeler-Zerilli waveforms at the light ring. The resulting phase difference around the merger time is as small as ±0.015 rad, with a fractional amplitude agreement of 2.5%. This suggest that next-to-quasicircular corrections to the phase can be a useful ingredient in comparisons between EOB and numerical-relativity waveforms.

  7. Scalable improvement of SPME multipolar electrostatics in anisotropic polarizable molecular mechanics using a general short-range penetration correction up to quadrupoles.

    Science.gov (United States)

    Narth, Christophe; Lagardère, Louis; Polack, Étienne; Gresh, Nohad; Wang, Qiantao; Bell, David R; Rackers, Joshua A; Ponder, Jay W; Ren, Pengyu Y; Piquemal, Jean-Philip

    2016-02-15

    We propose a general coupling of the Smooth Particle Mesh Ewald SPME approach for distributed multipoles to a short-range charge penetration correction modifying the charge-charge, charge-dipole and charge-quadrupole energies. Such an approach significantly improves electrostatics when compared to ab initio values and has been calibrated on Symmetry-Adapted Perturbation Theory reference data. Various neutral molecular dimers have been tested and results on the complexes of mono- and divalent cations with a water ligand are also provided. Transferability of the correction is adressed in the context of the implementation of the AMOEBA and SIBFA polarizable force fields in the TINKER-HP software. As the choices of the multipolar distribution are discussed, conclusions are drawn for the future penetration-corrected polarizable force fields highlighting the mandatory need of non-spurious procedures for the obtention of well balanced and physically meaningful distributed moments. Finally, scalability and parallelism of the short-range corrected SPME approach are addressed, demonstrating that the damping function is computationally affordable and accurate for molecular dynamics simulations of complex bio- or bioinorganic systems in periodic boundary conditions. © 2016 Wiley Periodicals, Inc. PMID:26814845

  8. The ablated volume and the thermal field distribution in swine vertebral body created by multi-polar radiofrequency ablation: an experiment in vitro

    International Nuclear Information System (INIS)

    Objective: To observe the extent of bone coagulation and the thermal field distribution created in ablating the swine vertebral bodies in vitro with multi-polar radiofrequency and to discuss the correlation between the electrode position in the vertebral body and the safety of the spinal cord as well as the soft tissue injury around the vertebral body. Methods: Thirty fresh adult porcine vertebrae were randomly and equally divided into two groups. The depth of the electrode needle was 10 mm or 20 mm.When the ablation process reached to a stable state, the temperature at the scheduled spots was estimated. Twenty minutes after ablation, the vertebral body was cut along the electrode needle plane and also along the plane perpendicular to the electrode needle to observe the extent of bone coagulation. Results: The temperature at the scheduled spots reached to a stable state in 3.5 minutes. The more close to the electrode the spot was, the more quickly the temperature rose. No soft tissue injury around the vertebral body was observed in both groups and no spinal cord injury occurred when the electrode needle was 10 mm or 20 mm deep in the vertebral body. Conclusion: In treating vertebral metastases, the radiofrequency ablation is safe and reliable if the posterior wall of the vertebral body remains intact. (authors)

  9. Modeling Choices in Nuclear Warfighting: Two Classroom Simulations on Escalation and Retaliation

    Science.gov (United States)

    Schofield, Julian

    2013-01-01

    Two classroom simulations--"Superpower Confrontation" and "Multipolar Asian Simulation"--are used to teach and test various aspects of the Borden versus Brodie debate on the Schelling versus Lanchester approach to nuclear conflict modeling and resolution. The author applies a Schelling test to segregate high from low empathic students, and assigns…

  10. Inspiral-merger-ringdown multipolar waveforms of nonspinning black-hole binaries using the effective-one-body formalism

    CERN Document Server

    Pan, Yi; Boyle, Michael; Buchman, Luisa T; Kidder, Lawrence E; Pfeiffer, Harald P; Scheel, Mark A

    2011-01-01

    We calibrate an effective-one-body (EOB) model to numerical-relativity simulations of mass ratios 1, 2, 3, 4, and 6, by maximizing phase and amplitude agreement of the leading (2,2) mode and of the subleading modes (2,1), (3,3), (4,4) and (5,5). Aligning the calibrated EOB waveforms and the numerical waveforms at low frequency, the phase difference of the (2,2) mode between model and numerical simulation remains below 0.1 rad throughout the evolution for all mass ratios considered. The fractional amplitude difference at peak amplitude of the (2,2) mode is 2% and grows to 12% during the ringdown. Using the Advanced LIGO noise curve we study the effectualness and measurement accuracy of the EOB model, and stress the relevance of modeling the higher-order modes for parameter estimation. We find that the effectualness, measured by the mismatch, between the EOB and numerical-relativity polarizations which include only the (2,2) mode is smaller than 0.2% for binaries with total mass 20-200 Msun and mass ratios 1, 2...

  11. A randomised controlled trial of ablation of Barrett's oesophagus with multipolar electrocoagulation versus argon plasma coagulation in combination with acid suppression: long term results

    Science.gov (United States)

    Sharma, P; Wani, S; Weston, A P; Bansal, A; Hall, M; Mathur, S; Prasad, A; Sampliner, R E

    2006-01-01

    Background Many modalities have been used to ablate Barrett's oesophagus (BO). However, long term results and comparative effectiveness are unknown. Aims Our aim was to compare the long term efficacy of achieving complete reversal (endoscopic and histological) between multipolar electrocoagulation (MPEC) and argon plasma coagulation (APC) in BO patients and assess factors influencing successful ablation. Methods Patients with BO, 2–6 cm long, underwent 24 hour pH testing on proton pump inhibitor (PPI) therapy. Patients were then randomised by BO length to undergo ablation with MPEC or APC every 4–8 weeks until endoscopic reversal or maximal of six treatment sessions. Results Thirty five BO patients have been followed for at least two years following endoscopic ablation, 16 treated with MPEC and 19 with APC. There was complete reversal of BO in 24 patients (69%); 75% with MPEC and 63% with APC (p = 0.49). There was no difference in the number of sessions required in the two groups. There was no difference in age, pH results, BO length, PPI dose, or hiatal hernia size between patients with and without complete reversal. One patient developed an oesophageal stricture but there were no major complications such as bleeding or perforation. Conclusions In BO patients treated with MPEC or APC in combination with acid suppression, at long term follow up, complete reversal of BO can be maintained in approximately 70% of patients, irrespective of the technique. There are no predictors associated with achieving complete reversal of BO. Continued surveillance is still indicated in the post ablative setting. As yet, these techniques are not ready for clinical application (other than for high grade dysplasia or early oesophageal adenocarcinoma) and cannot be offered outside the research arena. PMID:16905695

  12. Thomas-Fermi model electron density with correct boundary conditions: Application to atoms and ions

    International Nuclear Information System (INIS)

    The author proposes an electron density in atoms and ions, which has the Thomas-Fermi-Dirac form in the intermediate region of r, satisfies the Kato condition for small r, and has the correct asymptotic behavior at large values of r, where r is the distance from the nucleus. He also analyzes the perturbation in the density produced by multipolar fields. He uses these densities in the Poisson equation to deduce average values of rm, multipolar polarizabilities, and dispersion coefficients of atoms and ions. The predictions are in good agreement with experimental and other theoretical values, generally within about 20%. He tabulates here the coefficient A in the asymptotic density; radial expectation values (rm) for m = 2, 4, 6; multipolar polarizabilities ?1, ?2, ?3; expectation values left-angle r0 right-angle and left-angle r2 right-angle of the asymptotic electron density; and the van der Waals coefficient C6 for atoms and ions with 2 ? Z ? 92. Many of the results, particularly the multipolar polarizabilities and the higher order dispersion coefficients, are the only ones available in the literature. The variation of these properties also provides interesting insight into the shell structure of atoms and ions. Overall, the Thomas-Fermi-Dirac model with the correct boundary conditions provides a good global description of atoms and ions

  13. Imagens multipolarizadas do sensor Palsar/Alos na discriminação das fases fenológicas da cana?de?açúcar / Multipolarized Palsar/Alos images to discriminate sugarcane phenological phases

    Scientific Electronic Library Online (English)

    Michelle Cristina Araujo, Picoli; Rubens Augusto, Lamparelli; Edson Eyji, Sano; Jansle Vieira, Rocha.

    2012-09-01

    Full Text Available O objetivo deste trabalho foi avaliar o potencial das imagens multipolarizadas do sensor?radar Palsar/Alos em diferenciar as fases fenológicas da cana?de?açúcar. Valores digitais de quatro imagens do sensor, dos meses de fevereiro, maio, agosto e outubro de 2008, com polarizações HH (emissão e receb [...] imento de onda na polarização horizontal) e HV (emissão de onda na polarização horizontal e recebimento na vertical), foram convertidos para coeficientes de retroespalhamento (?°), para a análise de dados de cana?de?açúcar, cultivadas em talhões na região nordeste do Estado de São Paulo. Foram selecionadas três variedades, em diferentes estágios fenológicos: RB85?5156, seis talhões; RB86?7515, dez talhões; e RB92?5345, dez talhões. As diferenças entre as fases fenológicas foram avaliadas para cada uma das variedades e, também, entre as variedades. A utilização simultânea ou não dos dados do sensor Palsar/Alos, obtidos em duas polarizações, foi capaz de discriminar as diferentes fases de crescimento da cana?de?açúcar, com exceção da fase de crescimento dos colmos e a fase de maturação, em que não foi observada diferença significativa. Abstract in english The objective of this work was to evaluate the potential of multipolarized Palsar/Alos satellite images to discriminate phenological phases of sugarcane. Digital values from four digital images of February, May, August, and October 2008, with HH (sending and receiving wave in horizontal polarization [...] ) and HV polarizations (sending wave in horizontal polarization and receiving in vertical polarization), were converted to backscattering coefficients (?°) for data analysis of sugarcane cultivated in the northeastern of the state of São Paulo, Brazil. Three varieties were selected at different phenological stages: RB85?5156, six stands; RB86?7515, ten stands; and RB92?5345, ten stands. The differences between the phenological phases were analyzed for each variety, and also between varieties. The single or dual?poralized Palsar/Alos data, obtained in two polarizations, were able of discriminating the different phases of sugarcane growth, except for the grand growth period and maturity phase, in which no significant difference was observed.

  14. Comparison of giant multipole resonances of multipolarity E1 to E4 in 58Ni (T0 = 1) and 60Ni (T0 = 2) with inelastic electron scattering

    International Nuclear Information System (INIS)

    The cross section for electron scattering from the isotopes 58Ni and 60Ni has been measured with electrons of 102 MeV at scattering angles of 45, 60, 75, 90, and 1050 between 3 and 50 MeV excitation energy. Resonances or resonancelike structures at approximate excitation energies of (7--8) MeV, 13 MeV, (16 --17) MeV, (18--19) MeV, 27 MeV, 32 MeV, and 40 MeV were classified on the basis of their momentum transfer dependence and discussed in the framework of the shell model. Difficulties in the extraction of the cross section and model dependencies of the interpretation are discussed

  15. Clinical applications of magnetoencephalography in epilepsy

    Directory of Open Access Journals (Sweden)

    Ray Amit

    2010-01-01

    Full Text Available Magnetoencehalography (MEG is being used with increased frequency in the pre-surgical evaluation of patients with epilepsy. One of the major advantages of this technique over the EEG is the lack of distortion of MEG signals by the skull and intervening soft tissue. In addition, the MEG preferentially records activity from tangential sources thus recording activity predominantly from sulci, which is not contaminated by activity from apical gyral (radial sources. While the MEG is probably more sensitive than the EEG in detecting inter-ictal spikes, especially in the some locations such as the superficial frontal cortex and the lateral temporal neocortex, both techniques are usually complementary to each other. The diagnostic accuracy of MEG source localization is usually better as compared to scalp EEG localization. Functional localization of eloquent cortex is another major application of the MEG. The combination of high spatial and temporal resolution of this technique makes it an extremely helpful tool for accurate localization of visual, somatosensory and auditory cortices as well as complex cognitive functions like language. Potential future applications include lateralization of memory function.

  16. Information Content Analysis for the Multi-Viewing, Multi-Channel, Multi-Polarization Imaging (3MI) Instrument : Toward Retrieval of Vertically Resolved Cloud Properties from Passive Only Measurements.

    Science.gov (United States)

    Riedi, J.; Merlin, G.; Labonnote, L.; Cornet, C.; Ferlay, N.; Desmons, M.; Dubuisson, P.; Parol, F.; Davis, A. B.; Marbach, T.

    2014-12-01

    The EUMETSAT Polar System- Second Generation (EPS-SG) is currently under development to take over the current EUMETSAT Polar System at the 2020 horizon. As part of it, the Multi-Viewing Multi-Channel Multi-Polarization Imaging mission (3MI) will be dedicated to the operational monitoring of aerosols but will also provide unique observations for characterization of cloud properties building on the legacy of POLDER and particularly of its 3rd mission (PARASOL) within the A-Train. Through the synergy of POLDER3/PARASOL and MODIS/AQUA several studies have demonstrated the great interest of combining multispectral, multiangle and polarization measurements in the visible, near and shortwave infrared to better constrain retrieval of clouds microphysical and macrophysical properties. Remote-sensing of cloud thermodynamic phase (Riedi et al, 2010), liquid (Bréon and Doutriaux-Boucher, 2005) or ice clouds microphysics (Zhang et al, 2009; Cole et al, 2012), cloud radiative (Zeng et al, 2012) or macrophysical properties (Ferlay et al, 2010; Desmons et al, 2013) can unarguably benefit from the additional information content brought by polarization and multiangle measurements. At the same time, retrieval algorithms are gaining further complexity and skills. Thanks to availability of computational resources, practical implementation of optimal estimation or related optimization techniques (Delanoe & Hogan, 2008; Dubovik et al, 2013) have appeared that allow simultaneous and consistent retrieval of larger sets of parameters from constantly growing observations vectors. Therefore 3MI observations will not only allow to improve accuracy of future cloud products but also opens perspectives for the development of new retrieval algorithms. A major challenge for cloud remote-sensing from passive measurements is to obtain information on clouds properties vertical distribution and structure. Through results of a comprehensive information content analysis we will illustrate our current efforts to obtain vertically resolved information on cloud properties from 3MI passive measurements only. In particular the synergy of multiangle polarization measurements at 443 and 865 nm with Oxygen A-band differential absorption information to retrieve cloud geometrical thickness will be discussed.

  17. Internal conversion calculations in Hartree-Fock atomic model: improved agreement with experiment

    Energy Technology Data Exchange (ETDEWEB)

    Dragoun, O.; Rysavy, M.; Becvar, F.; Brabec, V. (Ceskoslovenska Akademie Ved, Rez. Ustav Jaderne Fyziky)

    1981-01-01

    Two relativistic, independent-particle atomic models are employed to calculate two sets of internal conversion coefficients, viz., the Hartree-Fock model and the Hartree-Fock-Slater model with the weighting factor C=1 in the exchange term. Eight transitions with energies of 50 to 412 keV, multipolarities, M1,E2,E3,M4, in nuclei with Z=47 to 80 are considered. The former set of the conversion coefficients is found to agree substantially better with 68 experimental data than the latter.

  18. Internal conversion calculations in Hartree-Fock atomic model: improved agreement with experiment

    International Nuclear Information System (INIS)

    Two relativistic, independent-particle atomic models are employed to calculate two sets of internal conversion coefficients, viz., the Hartree-Fock model and the Hartree-Fock-Slater model with the weighting factor C=1 in the exchange term. Eight transitions with energies of 50 to 412 keV, multipolarities, M1,E2,E3,M4, in nuclei with Z=47 to 80 are considered. The former set of the conversion coefficients is found to agree substantially better with 68 experimental data than the latter. (author)

  19. The african protoproverbial in a multipolar world

    OpenAIRE

    Taiwo, ?l?runt?ba-Oju

    2014-01-01

    The proverb is a rhetorical universal and as such shares features across linguistic, ethnic and culture boundaries, thus making typological distinctions along ethnic or regional lines a daunting task. Further complicating this scenario within the African context is the relentless hybridization and subversion of the African proverb consequent on colonial contact and sundry postcolonial interventions. This twin trajectory, the conceptual universalism of the proverb and the relent...

  20. Some New Applications of Weyl's Multipolarization Operators

    CERN Document Server

    Towber, J

    2001-01-01

    In Weyl's "The Classical Groups", he introduces some some remarkable differential operators, which he calls "quasi-compositions" of the polarization operators Dij. In the present paper, an equivalent combinatorial formulation is obtained for these operators, and is then used to obtain explicit formulas for the differentials in certain complexes (constucted by Zelevinsky, and further studied by Verma, Akin et al.) which furnish higher syzygies for the Pluecker equations, and also for the defining relations for Weyl modules.

  1. Modeling and detecting deep brain activity with MEG & EEG.

    Science.gov (United States)

    Attal, Yohan; Bhattacharjee, Manik; Yelnik, Jerome; Cottereau, Benoit; Lefèvre, Julien; Okada, Yoshio; Bardinet, Eric; Chupin, Marie; Baillet, Sylvain

    2007-01-01

    We introduce an anatomical and electrophysiological model of deep brain structures dedicated to magnetoencephalography (MEG) and electroencephalography (EEG) source imaging. So far, most imaging inverse models considered that MEG/EEG surface signals were predominantly produced by cortical, hence superficial, neural currents. Here we question whether crucial deep brain structures such as the basal ganglia and the hippocampus may also contribute to distant, scalp MEG and EEG measurements. We first design a realistic anatomical and electrophysiological model of these structures and subsequently run Monte-Carlo experiments to evaluate the respective sensitivity of the MEG and EEG to signals from deeper origins. Results indicate that MEG/EEG may indeed localize these deeper generators, which is confirmed here from experimental MEG data reporting on the modulation of alpha brain waves. PMID:18003114

  2. Giant monopole resonances in the statistical model

    International Nuclear Information System (INIS)

    The strength functions for e+-e- pair decay of the isoscalar and isovector giant monopole resonances in highly excited nuclei are derived and used in a statistical model calculation of the e+e- pair energy spectrum from compound nuclear decay in 110Sn following a fusion evaporation reaction. This result is then compared to the e+-e- spectrum derived from internal pair decay of the giant dipole and giant quadrupole resonances. The computation shows that the pair decay from the excited-state GDR dominates the pair spectrum over the region of all giant resonances, exceeding L=0 transitions by at least a factor of ten. We also compute the angular correlations between e+ and e- for the L=0, L=1 and L=2 transitions and estimate their power to discriminate between the various multipolarities. (orig.)

  3. Dynamical modeling and the interactions with the ISM

    CERN Document Server

    Steffen, Wolfgang

    2011-01-01

    This paper is a review of some of the recent modeling efforts to improve our understanding of structure formation and evolution of planetary nebulae including their interaction with the interstellar medium. New propositions have been made for the formation mechanism of multi-polar PNe and PPNe. These mechanisms are based on the central engine with interacting binary stars or hole producing instabilities in expanding shock waves leading to illumination effects from the central star that change the appearance of the nebula. Furthermore, there has been a lot of progress in the observation and 3D modeling of the kinematics, which is key to the understanding of the dynamics. Extensive observational catalogs are coming online for the kinematics, as well as some very detailed proper motion measurements have been made. New techniques for morpho--kinematic 3D modeling help to make the interpretation of kinematic data more reliable and detailed. In addition to individual pointed observations, new surveys have lead to t...

  4. Integrating the disaster cycle model into traditional disaster diplomacy concepts.

    Science.gov (United States)

    Callaway, David W; Yim, Eugene S; Stack, Colin; Burkle, Frederick M

    2012-03-01

    Disaster diplomacy is an evolving contemporary model that examines how disaster response strategies can facilitate cooperation between parties in conflict. The concept of disaster diplomacy has emerged during the past decade to address how disaster response can be leveraged to promote peace, facilitate communication, promote human rights, and strengthen intercommunity ties in the increasingly multipolar modern world. Historically, the concept has evolved through two camps, one that focuses on the interactions between national governments in conflict and another that emphasizes the grassroots movements that can promote change. The two divergent approaches can be reconciled and disaster diplomacy further matured by contextualizing the concept within the disaster cycle, a model well established within the disaster risk management community. In particular, access to available health care, especially for the most vulnerable populations, may need to be negotiated. As such, disaster response professionals, including emergency medicine specialists, can play an important role in the development and implementation of disaster diplomacy concepts. PMID:22490937

  5. Giant resonance of electrical multipole from droplet model

    International Nuclear Information System (INIS)

    The formalism of the electrical multipole resonance developed from the Droplet nuclear model is presented. It combines the approaches of Goldhaber-Teller (GT) and Steinwedel-Jensen (SJ) and it shows the relative contribution of Coulomb, superficial and neutron excess energies. It also discusses the calculation of half-width. The model evaluates correctly the resonance energies as a function of nuclear mass and allows, through the Mixture Index, the prediction of the complementary participation of modes SJ and GT in the giant nuclear resonance. Values of the mixture index, for each multipolarity, reproduce well the form factors obtained from experiments of charged particle inelastic scattering. The formalism presented for the calculation of the half-width gives a macroscopic description of the friction mechanism. The establishment of the macroscopic structure of the Dissipation Function is used as a reference in the comparison of microscopic calculations. (Author)

  6. Charged patchy particle models in explicit salt: Ion distributions, electrostatic potentials, and effective interactions.

    Science.gov (United States)

    Yigit, Cemil; Heyda, Jan; Dzubiella, Joachim

    2015-08-14

    We introduce a set of charged patchy particle models (CPPMs) in order to systematically study the influence of electrostatic charge patchiness and multipolarity on macromolecular interactions by means of implicit-solvent, explicit-ion Langevin dynamics simulations employing the Gromacs software. We consider well-defined zero-, one-, and two-patched spherical globules each of the same net charge and (nanometer) size which are composed of discrete atoms. The studied mono- and multipole moments of the CPPMs are comparable to those of globular proteins with similar size. We first characterize ion distributions and electrostatic potentials around a single CPPM. Although angle-resolved radial distribution functions reveal the expected local accumulation and depletion of counter- and co-ions around the patches, respectively, the orientation-averaged electrostatic potential shows only a small variation among the various CPPMs due to space charge cancellations. Furthermore, we study the orientation-averaged potential of mean force (PMF), the number of accumulated ions on the patches, as well as the CPPM orientations along the center-to-center distance of a pair of CPPMs. We compare the PMFs to the classical Derjaguin-Verwey-Landau-Overbeek theory and previously introduced orientation-averaged Debye-Hückel pair potentials including dipolar interactions. Our simulations confirm the adequacy of the theories in their respective regimes of validity, while low salt concentrations and large multipolar interactions remain a challenge for tractable theoretical descriptions. PMID:26277163

  7. Charged patchy particle models in explicit salt: Ion distributions, electrostatic potentials, and effective interactions

    Science.gov (United States)

    Yigit, Cemil; Heyda, Jan; Dzubiella, Joachim

    2015-08-01

    We introduce a set of charged patchy particle models (CPPMs) in order to systematically study the influence of electrostatic charge patchiness and multipolarity on macromolecular interactions by means of implicit-solvent, explicit-ion Langevin dynamics simulations employing the Gromacs software. We consider well-defined zero-, one-, and two-patched spherical globules each of the same net charge and (nanometer) size which are composed of discrete atoms. The studied mono- and multipole moments of the CPPMs are comparable to those of globular proteins with similar size. We first characterize ion distributions and electrostatic potentials around a single CPPM. Although angle-resolved radial distribution functions reveal the expected local accumulation and depletion of counter- and co-ions around the patches, respectively, the orientation-averaged electrostatic potential shows only a small variation among the various CPPMs due to space charge cancellations. Furthermore, we study the orientation-averaged potential of mean force (PMF), the number of accumulated ions on the patches, as well as the CPPM orientations along the center-to-center distance of a pair of CPPMs. We compare the PMFs to the classical Derjaguin-Verwey-Landau-Overbeek theory and previously introduced orientation-averaged Debye-Hückel pair potentials including dipolar interactions. Our simulations confirm the adequacy of the theories in their respective regimes of validity, while low salt concentrations and large multipolar interactions remain a challenge for tractable theoretical descriptions.

  8. Modeling versus accuracy in EEG and MEG data

    Energy Technology Data Exchange (ETDEWEB)

    Mosher, J.C.; Huang, M. [Los Alamos National Lab., NM (United States); Leahy, R.M. [Univ. of Southern California, Los Angeles, CA (United States); Spencer, M.E. [Signal Processing Solutions, Redondo Beach, CA (United States)

    1997-07-30

    The widespread availability of high-resolution anatomical information has placed a greater emphasis on accurate electroencephalography and magnetoencephalography (collectively, E/MEG) modeling. A more accurate representation of the cortex, inner skull surface, outer skull surface, and scalp should lead to a more accurate forward model and hence improve inverse modeling efforts. The authors examine a few topics in this paper that highlight some of the problems of forward modeling, then discuss the impacts these results have on the inverse problem. The authors begin by assuming a perfect head model, that of the sphere, then show the lower bounds on localization accuracy of dipoles within this perfect forward model. For more realistic anatomy, the boundary element method (BEM) is a common numerical technique for solving the boundary integral equations. For a three-layer BEM, the computational requirements can be too intensive for many inverse techniques, so they examine a few simplifications. They quantify errors in generating this forward model by defining a regularized percentage error metric. The authors then apply this metric to a single layer boundary element solution, a multiple sphere approach, and the common single sphere model. They conclude with an MEG localization demonstration on a novel experimental human phantom, using both BEM and multiple spheres.

  9. Magnetoencephalography Demonstrates Multiple Asynchronous Generators During Human Sleep Spindles

    OpenAIRE

    Dehghani, Nima; Cash, Sydney S.; Rossetti, Andrea O.; Chen, Chih Chuan; Halgren, Eric

    2010-01-01

    Sleep spindles are ?1 s bursts of 10–16 Hz activity that occur during stage 2 sleep. Spindles are highly synchronous across the cortex and thalamus in animals, and across the scalp in humans, implying correspondingly widespread and synchronized cortical generators. However, prior studies have noted occasional dissociations of the magnetoencephalogram (MEG) from the EEG during spindles, although detailed studies of this phenomenon have been lacking. We systematically compared high-density MEG ...

  10. Magnetoencephalography reveals thalamocortical dysrhythmia in children born very preterm

    Directory of Open Access Journals (Sweden)

    Alexander Moiseev

    2010-04-01

    Full Text Available Very preterm children without major intellectual impairment, at school age often show selective deficits in executive function, memory, and problem solving. Little is known about what differences in brain activity underlie such cognitive problems. Reduced thalamic volume and white matter abnormalities revealed by MRI suggest that thalamocortical dynamics may be altered in children born very preterm. Thalamocortical dysrhythmia (TCD, characterized by altered oscillatory network activity related to thalamocortical connectivity, has been previously identified in several neurological and neuropsychiatric conditions. To examine whether altered oscillatory brain dynamics in children born very preterm indicate the presence of TCD, we recorded resting MEG from 11 children born ?32 weeks gestation (mean 30.3, sd 2.4, and 11 age-matched full-term controls at age 7.5 years. No child had significant brain injury or intellectual impairment. Data from each of 151 MEG sensors was narrowly bandpass filtered at 1 Hz intervals from 4 – 50 Hz to determine spectral power. Preterm children, relative to controls, exhibited a number of alterations in resting MEG consistent with TCD (p < 0.05: a reduced alpha-band power b a shift in the peak of oscillatory power from the alpha range toward the lower-frequency theta-band which was maximal over bilateral frontal cortex; c increased cross-frequency coupling over bilateral frontal cortex. In addition, there were trends toward increased theta oscillations at the frontal peak of this frequency shift and widespread increases in gamma-band power. In a group of children born very preterm but without intellectual impairment, specific changes in resting MEG activity indicate slight-to-moderate thalamocortical dysrhythmia. The concentration of oscillatory slowing in bilateral frontal cortex suggests that altered thalamocortical dynamics may underlie specific cognitive problems commonly diagnosed in this population. Funding: NIH grant HD039783-06A2 to REG.

  11. Distorted cortical networks in dislexia: findings using Magnetoencephalography (MEG

    Directory of Open Access Journals (Sweden)

    Eduardo M. Catillo

    2008-04-01

    Full Text Available In dyslexic children a functional deficit in the brain circuitry supporting some of the cognitive operations taking place while they learn how the printed words maps onto spoken language is suspected. Until recently, however, no information existed regarding the functional status of this circuit during the early stages of reading acquisition. In the context of three studies we sought to address key issues in the pathophysiology of this condition using Magnetoencephalograhy (MEG at the University of Texas-Houston. The first study, including 30 kindergarten children at risk for developing reading problems and 15 not-at-risk controls, ascertained that the aberrant neural circuit that underlies reading problems appears to be present in the initial stages of reading acquisition. A subset of these children were retested a year later using identical procedures in a second study. Children in the at-risk group showed the most prominent changes in brain activation profiles and successfully predicted individual differences in the growth of reading skill measures. The results of a third study showed clearly that the aberrant activation profile can be normalized following intensive behavioral instruction. These findings are consistent with the view that dyslexia represents a functional deficit in the neural network that mediates the conversion of print to sound, which is amenable to change given adequate instruction.

  12. Adaptive Cluster Analysis Approach for Functional Localization Using Magnetoencephalography

    OpenAIRE

    HoomanAlikhanian; J. DouglasCrawford

    2013-01-01

    In this paper we propose an agglomerative hierarchical clustering Ward’s algorithm in tandem with the Affinity Propagation algorithm to reliably localize active brain regions from magnetorencephalography (MEG) brain signals. Reliable localization of brain areas with MEG has been difficult due to variations in signal strength, and the spatial extend of the reconstructed activity. The proposed approach to resolve this difficulty is based on adaptive clustering on reconstructed beamformer images...

  13. Noise cancellation in magnetoencephalography and electroencephalography with isolated reference sensors

    Science.gov (United States)

    Kraus, Jr., Robert H.; Espy, Michelle A.; Matlachov, Andrei; Volegov, Petr

    2010-06-01

    An apparatus measures electromagnetic signals from a weak signal source. A plurality of primary sensors is placed in functional proximity to the weak signal source with an electromagnetic field isolation surface arranged adjacent the primary sensors and between the weak signal source and sources of ambient noise. A plurality of reference sensors is placed adjacent the electromagnetic field isolation surface and arranged between the electromagnetic isolation surface and sources of ambient noise.

  14. Decoding Brain States Based on Magnetoencephalography From Prespecified Cortical Regions.

    Science.gov (United States)

    Zhang, Jinyin; Li, Xin; Foldes, Stephen T; Wang, Wei; Collinger, Jennifer L; Weber, Douglas J; Bagic, Anto

    2016-01-01

    Brain state decoding based on whole-head MEG has been extensively studied over the past decade. Recent MEG applications pose an emerging need of decoding brain states based on MEG signals originating from prespecified cortical regions. Toward this goal, we propose a novel region-of-interest-constrained discriminant analysis algorithm (RDA) in this paper. RDA integrates linear classification and beamspace transformation into a unified framework by formulating a constrained optimization problem. Our experimental results based on human subjects demonstrate that RDA can efficiently extract the discriminant pattern from prespecified cortical regions to accurately distinguish different brain states. PMID:26699648

  15. Investigating neurophysiological correlates of metacontrast masking with magnetoencephalography

    Directory of Open Access Journals (Sweden)

    Jens Schwarzbach

    2006-01-01

    Full Text Available Early components of visual evoked potentials (VEP in EEG seem to be unaffected by target visibility in visual masking studies. Bridgeman's reanalysis of Jeffreys and Musselwhite's (1986 data suggests that a later visual component in the VEP, around 250 ms reflects the perceptual effect of masking. We challenge this view on the ground that temporal interactions between targets and masks unrelated to stimulus visibility could account for Bridgeman's observation of a U-shaped time course in VEP amplitudes for this later component. In an MEG experiment of metacontrast masking with variable stimulus onset asynchrony, we introduce a proper control, a pseudo mask. In contrast to an effective mask, the pseudomask should produce neither behavioral masking nor amplitude modulations of late VEPs. Our results show that effective masks produced a strong U-shaped perceptual effect of target visibility while performance remained virtually perfect when a pseudomask was used. The visual components around 250 ms after target onset did not show a distinction between mask and pseudomask conditions. The results indicate that these visual evoked potentials do not reveal neurophysiological correlates of stimulus visibility but rather reflect dynamic interactions between superimposed potentials elicited by stimuli in close temporal proximity. However, we observed a postperceptual component around 340 ms after target onset, located over temporal-parietal cortex, which shows a clear effect of visibility. Based on P300 ERP literature, this finding could indicate that working memory related processes contribute to metacontrast masking.

  16. Electro-magneto-encephalography for the three-shell model: numerical implementation via splines for distributed current in spherical geometry

    International Nuclear Information System (INIS)

    The basic inverse problems for the functional imaging techniques of electroencephalography (EEG) and magnetoencephalography (MEG) consist in estimating the neuronal current in the brain from the measurement of the electric potential on the scalp and of the magnetic field outside the head. Here we present a rigorous derivation of the relevant formulae for a three-shell spherical model in the case of independent as well as simultaneous MEG and EEG measurements. Furthermore, we introduce an explicit and stable technique for the numerical implementation of these formulae via splines. Numerical examples are presented using the locations and the normal unit vectors of the real 102 magnetometers and 70 electrodes of the Elekta Neuromag (R) system. These results may have useful implications for the interpretation of the reconstructions obtained via the existing approaches. (paper)

  17. THE FILAMENTARY MULTI-POLAR PLANETARY NEBULA NGC5189

    Directory of Open Access Journals (Sweden)

    L. Sabin

    2012-01-01

    Full Text Available We present a set of optical and infrared images combined with long-slit, medium and high dispersion spectra of the southern planetary nebula (PN NGC5189. The complex morphology of this PN is puzzling and has not been studied in detailed so far. Our investigation reveals the presence of a new dense and cold infrared torus (alongside the optical one which probably generated one of the two optically seen bipolar outflows and which might be responsible for the twisted appearance of the optical torus via an interaction process. The high-resolution MES-AAT spectra clearly show the presence of filamentary and knotty structures as well as three expanding bubbles. Our findings therefore suggest that NGC5189 is a quadrupolar nebula with multiple sets of symmetrical condensations in which the interaction of outflows has determined its complex morphology.

  18. A pair spectrometer for measuring multipolarities of energetic nuclear transitions

    CERN Document Server

    Gulyás, J; Krasznahorkay, A J; Csatlós, M; Csige, L; Gácsi, Z; Hunyadi, M; Krasznahorkay, A; Vitéz, A; Tornyi, T G

    2015-01-01

    A multi-detector array has been designed and constructed for the simultaneous measurement of energy- and angular correlations of electron-positron pairs. Experimental results are obtained over a wide angular range for high-energy transitions in 16O, 12C and 8Be. A comparison with GEANT simulations demonstrates that angular correlations between 50 and 180 degrees of the electron-positron pairs in the energy range between 6 and 18 MeV can be determined with sufficient resolution and efficiency.

  19. A pair spectrometer for measuring multipolarities of energetic nuclear transitions

    Science.gov (United States)

    Gulyás, J.; Ketel, T. J.; Krasznahorkay, A. J.; Csatlós, M.; Csige, L.; Gácsi, Z.; Hunyadi, M.; Krasznahorkay, A.; Vitéz, A.; Tornyi, T. G.

    2016-02-01

    An electron-positron pair spectrometer has been designed and constructed for the simultaneous measurement of energy- and angular correlations of e+e- pairs. Experimental results are obtained over a wide angular range for high-energy transitions in 16O, 12C and 8Be. The results showed that the angular correlations between 50 and 180° of the e+e- pairs in the energy range between 6 and 18 MeV can be determined with sufficient resolution and efficiency in good agreement with the GEANT simulations.

  20. The filamentary multi-polar planetary nebula NGC 5189

    Scientific Electronic Library Online (English)

    L., Sabin; R., Vázquez; J. A., López; Ma. T., García-Díaz; G., Ramos-Larios.

    2012-10-01

    Full Text Available Presentamos un conjunto de imágenes ópticas e infrarrojas combinadas con espectros de rendija larga de mediana y alta dispersión de la Nebulosa Planetaria (NP) del sur NGC 5189. La compleja morfología de esta NP es desconcertante y no había sido estudiada en detalle hasta ahora. Nuestra investigació [...] n revela la presencia de un toroide denso y frío, en el infrarrojo, el cual probablemente generó uno de los dos flujos bipolares vistos en el óptico y podría, mediante un proceso de interacción, ser también responsable de la apariencia retorcida del toroide óptico. Los espectros de alta resolución del MES-AAT muestran claramente la presencia de nudos y estructuras filamentosas, así como tres burbujas en expansión. Nuestros hallazgos sugieren que NGC 5189 es una NP cuadrupolar con varios conjuntos de condensaciones simétricas en la cual la interacción de flujos determinó su compleja morfología. Abstract in english We present a set of optical and infrared images combined with long-slit, medium and high dispersion spectra of the southern planetary nebula (PN) NGC 5189. The complex morphology of this PN is puzzling and has not been studied in detailed so far. Our investigation reveals the presence of a new dense [...] and cold infrared torus (alongside the optical one) which probably generated one of the two optically seen bipolar outflows and which might be responsible for the twisted appearance of the optical torus via an interaction process. The high-resolution MES-AAT spectra clearly show the presence of filamentary and knotty structures as well as three expanding bubbles. Our findings therefore suggest that NGC 5189 is a quadrupolar nebula with multiple sets of symmetrical condensations in which the interaction of outflows has determined its complex morphology.

  1. China's Soft Diplomacy in an Emerging Multi-polar World

    OpenAIRE

    Schmidt, Johannes Dragsbæk

    2011-01-01

    Keynote presentation for the conference"The Growing Prominence of China on the World Stage: Exploring the Political, Economic, and Cultural Relations of China and Global Stakeholders" International Conference, Berlin, September 15th - 18th, 2011 - Held Parallel to the "Berlin - Asia Pacific Weeks Conference 2011

  2. China's Soft Diplomacy in an Emerging Multi-polar World

    DEFF Research Database (Denmark)

    Schmidt, Johannes Dragsbæk

    Keynote presentation for the conference"The Growing Prominence of China on the World Stage: Exploring the Political, Economic, and Cultural Relations of China and Global Stakeholders" International Conference, Berlin, September 15th - 18th, 2011 - Held Parallel to the "Berlin - Asia Pacific Weeks...

  3. The filamentary Multi-Polar Planetary Nebula NGC 5189

    CERN Document Server

    Sabin, L; López, J A; García-Díaz, Ma T; Ramos-Larios, G

    2012-01-01

    We present a set of optical and infrared images combined with long-slit, medium and high dispersion spectra of the southern planetary nebula (PN) NGC 5189. The complex morphology of this PN is puzzling and has not been studied in detail so far. Our investigation reveals the presence of a new dense and cold infrared torus (alongside the optical one) which probably generated one of the two optically seen bipolar outflows and which might be responsible for the twisted appearance of the optical torus via an interaction process. The high-resolution MES-AAT spectra clearly show the presence of filamentary and knotty structures as well as three expanding bubbles. Our findings therefore suggest that NGC 5189 is a quadrupolar nebula with multiple sets of symmetrical condensations in which the interaction of outflows has determined the complex morphology.

  4. GEOPOLITICAL STRATEGIES AND MODERNITY: MULTIPOLAR WORLD OF NOWADAYS

    Directory of Open Access Journals (Sweden)

    Radenko Scekic

    2016-01-01

    Full Text Available The political map of the planet has transformed substantially during the last century. Former colonial powers had to be satisfied with the perfidious forms of political and economic control. The last decades were marked by the global dominance of the US and its allies, as well as the military superiority of the NATO pact. The beginning of the new millennium was filled with military and financial crises. On the global stage have appeared new economic and military powers and organizations such as the BRICS, the Eurasian Union, the economic power of China, and Russia's comeback in the geopolitical games. The former geopolitical theories become topical again.

  5. Multipolar ordering in NpO2 below 25 K

    International Nuclear Information System (INIS)

    The phase transition at T0 = 25 K in NpO2 and the single-ion nature of the Np 5f electrons is examined in the light of the results of resonant x-ray scattering experiments at the M4 Np edge. These experiments exclude usual magnetic dipole ordering at T0, and provide direct evidence of long-range order of the electric quadrupole moment with ?5 symmetry. The phase transition is purely electronic and does not involve either internal or external crystallographic distortions, so the symmetry of the system remains cubic. The primary order parameter (OP) is associated with ?4t magnetic octupoles, ordering in a triple-q longitudinal structure defined by the three wavevectors of the (001) star. Magnetic octupolar order breaks invariance under time reversal and induces the order of electric quadrupoles as the secondary OP. The resulting ground state is a singlet with zero dipole magnetic moment

  6. Automatic procedure for realistic 3D finite element modelling of human brain for bioelectromagnetic computations

    International Nuclear Information System (INIS)

    Realistic computer modelling of biological objects requires building of very accurate and realistic computer models based on geometric and material data, type, and accuracy of numerical analyses. This paper presents some of the automatic tools and algorithms that were used to build accurate and realistic 3D finite element (FE) model of whole-brain. These models were used to solve the forward problem in magnetic field tomography (MFT) based on Magnetoencephalography (MEG). The forward problem involves modelling and computation of magnetic fields produced by human brain during cognitive processing. The geometric parameters of the model were obtained from accurate Magnetic Resonance Imaging (MRI) data and the material properties - from those obtained from Diffusion Tensor MRI (DTMRI). The 3D FE models of the brain built using this approach has been shown to be very accurate in terms of both geometric and material properties. The model is stored on the computer in Computer-Aided Parametrical Design (CAD) format. This allows the model to be used in a wide a range of methods of analysis, such as finite element method (FEM), Boundary Element Method (BEM), Monte-Carlo Simulations, etc. The generic model building approach presented here could be used for accurate and realistic modelling of human brain and many other biological objects.

  7. Automatic procedure for realistic 3D finite element modelling of human brain for bioelectromagnetic computations

    Energy Technology Data Exchange (ETDEWEB)

    Aristovich, K Y; Khan, S H, E-mail: kirill.aristovich.1@city.ac.u [School of Engineering and Mathematical Sciences, City University London, Northampton Square, London EC1V 0HB (United Kingdom)

    2010-07-01

    Realistic computer modelling of biological objects requires building of very accurate and realistic computer models based on geometric and material data, type, and accuracy of numerical analyses. This paper presents some of the automatic tools and algorithms that were used to build accurate and realistic 3D finite element (FE) model of whole-brain. These models were used to solve the forward problem in magnetic field tomography (MFT) based on Magnetoencephalography (MEG). The forward problem involves modelling and computation of magnetic fields produced by human brain during cognitive processing. The geometric parameters of the model were obtained from accurate Magnetic Resonance Imaging (MRI) data and the material properties - from those obtained from Diffusion Tensor MRI (DTMRI). The 3D FE models of the brain built using this approach has been shown to be very accurate in terms of both geometric and material properties. The model is stored on the computer in Computer-Aided Parametrical Design (CAD) format. This allows the model to be used in a wide a range of methods of analysis, such as finite element method (FEM), Boundary Element Method (BEM), Monte-Carlo Simulations, etc. The generic model building approach presented here could be used for accurate and realistic modelling of human brain and many other biological objects.

  8. Evaluation of multiple-sphere head models for MEG source localization

    International Nuclear Information System (INIS)

    Magnetoencephalography (MEG) source analysis has largely relied on spherical conductor models of the head to simplify forward calculations of the brain's magnetic field. Multiple- (or overlapping, local) sphere models, where an optimal sphere is selected for each sensor, are considered an improvement over single-sphere models and are computationally simpler than realistic models. However, there is limited information available regarding the different methods used to generate these models and their relative accuracy. We describe a variety of single- and multiple-sphere fitting approaches, including a novel method that attempts to minimize the field error. An accurate boundary element method simulation was used to evaluate the relative field measurement error (12% on average) and dipole fit localization bias (3.5 mm) of each model over the entire brain. All spherical models can contribute in the order of 1 cm to the localization bias in regions of the head that depart significantly from a sphere (inferior frontal and temporal). These spherical approximation errors can give rise to larger localization differences when all modeling effects are taken into account and with more complex source configurations or other inverse techniques, as shown with a beamformer example. Results differed noticeably depending on the source location, making it difficult to recommend a fitting method that performs best in general. Given these limitations, it may be advisable to expand the use of realistic head models.

  9. Generalized Multipole X-Wind Model

    Science.gov (United States)

    Mohanty, Subhanjoy; Shu, Frank H.

    The X-wind model for magnetospheric accretion and outflow in classical T Tauri stars (CTTS) has gained credence in recent years for a variety of theoretical and observational reasons. However, both this model as well as other theoretical scenarios for explaining magnetospheric disk accretion assume that the stellar field, were it not perturbed by an electrically conducting accretion disk, would have a dipolar geometry (e.g., [5]; OS95 hereafter). Observations of accretion hot spot sizes and net field polarization on the surface of CTTS, however, clearly indicate that the stellar field has a complex multipolar structure. To overcome this discrepancy between theory and data, we reformulate X-wind theory without the dipole constraint. This contribution represents a brief summary of the paper by Mohanty and Shu [6]. In Sect. 1 we present the fundamental physical ideas of the generalized theory, and the associated equations; in Sect. 2 we compare the resulting theoretical prediction to recent observations, and provide some illustrative numerical simulations with multipole stellar fields.

  10. Models

    DEFF Research Database (Denmark)

    Juel-Christiansen, Carsten

    Artiklen fremhæver den visuelle rotation - billeder, tegninger, modeller, værker - som det privilligerede medium i kommunikationen af ideer imellem skabende arkitekter......Artiklen fremhæver den visuelle rotation - billeder, tegninger, modeller, værker - som det privilligerede medium i kommunikationen af ideer imellem skabende arkitekter...

  11. Mercado Simbólico: um modelo de comunicação para políticas públicas / The symbolic market: a communication model for public policies / Mercado Simbólico: un modelo de comunicación para políticas públicas

    Scientific Electronic Library Online (English)

    Inesita Soares de, Araújo.

    2004-02-01

    Full Text Available O trabalho tem como objetivo propor um modelo para análise e planejamento estratégico da comunicação nas políticas públicas, considerando que os modelos correntes não dão conta adequadamente da prática comunicativa nos processos de intervenção social, frustrando os altos investimentos e expectativas [...] que despertam. O "Modelo do Mercado Simbólico", em rede, descentrado e multipolar, é composto por uma formulação teórica, uma representação gráfica dos principais componentes e suas relações e de uma matriz de análise e planejamento estratégico das relações comunicativas. A representação gráfica contempla: a rede de sentidos sociais, os interlocutores e seus contextos e "lugar de interlocução". A matriz inclui fontes, campos, instâncias, comunidades discursivas e uma tipologia de fatores de mediação. Abstract in spanish El trabajo tiene como objetivo proponer un modelo para análisis y planificación estratégica de la comunicación en las políticas públicas, considerando que los modelos corrientes no sustentan adecuadamente la práctica comunicativa en los procesos de intervención social, frustrando las altas inversion [...] es y expectativas que despiertan. El "Modelo del Mercado Simbólico", en red, descentrado y multipolar, es compuesto por una formulación teórica, una representación gráfica de los principales componentes y sus relaciones y de una matriz de análisis y planificación estratégica de las relaciones comunicativas. La representación gráfica contempla: la red de sentidos sociales, los interlocutores y sus contextos y "lugar de interlocución". La matriz incluye fuentes, campos, instancias, comunidades discursivas y una tipología de factores de mediación. Abstract in english The purpose of this paper is to put forth a model for the analysis and strategic planning of the communication of public policies, given that the current models fail to adequately fulfill communication requirements in the processes of social intervention, frustrating the high investments and expecta [...] tions that they give rise to. The "Symbolic Market Model", in network form, both decentralized and multipolar, is comprised of (i) a theoretical formulation, (ii) a graphical representation of the main components and the relations between them and (iii) an analysis and strategic planning matrix of communicative relations. The graphic representation takes into account: the network of social senses, the interlocutors and their contexts, and the "place of dialogue". The matrix includes sources, fields, instances, discursive communities and a typology of mediation factors.

  12. Modelling

    CERN Document Server

    Spädtke, P

    2013-01-01

    Modeling of technical machines became a standard technique since computer became powerful enough to handle the amount of data relevant to the specific system. Simulation of an existing physical device requires the knowledge of all relevant quantities. Electric fields given by the surrounding boundary as well as magnetic fields caused by coils or permanent magnets have to be known. Internal sources for both fields are sometimes taken into account, such as space charge forces or the internal magnetic field of a moving bunch of charged particles. Used solver routines are briefly described and some bench-marking is shown to estimate necessary computing times for different problems. Different types of charged particle sources will be shown together with a suitable model to describe the physical model. Electron guns are covered as well as different ion sources (volume ion sources, laser ion sources, Penning ion sources, electron resonance ion sources, and H$^-$-sources) together with some remarks on beam transport.

  13. Modelling

    International Nuclear Information System (INIS)

    This last volume in the series of textbooks on environmental isotopes in the hydrological cycle provides an overview of the basic principles of existing conceptual formulations of modelling approaches. While some of the concepts provided in Chapter 2 and Chapter 3 are of general validity for quantitative interpretation of isotope data; the modelling methodologies commonly employed for incorporating isotope data into evaluations specifically related to groundwater systems are given in this volume together with some illustrative examples. Development of conceptual models for quantitative interpretations of isotope data in hydrogeology and the assessment of their limitations and field verification has been given priority in the research and development efforts of the IAEA during the last decade. Several Co-ordinated Research Projects on this specific topic were implemented and results published by the IAEA. Based on these efforts and contributions made by a number of scientists involved in this specific field, the IAEA has published two Technical Documents entitled ''Mathematical models and their applications to isotope studies in groundwater studies -- IAEA TECDOC-777, 1994'' and ''Manual on Mathematical models in isotope hydrogeology -- IAEA TECDOC-910, 1996''. Results of a recently completed Co-ordinated Research Project by the IAEA entitled ''Use of isotopes for analysis of flow and transport dynamics in groundwater systems'' will also soon be published by the IAEA. This is the reason why the IAEA was involved in the co-ordination required for preparation of this volume; the material presented is a condensed overview prepared by some of the scientists that were involved in the above cited IAEA activities. This volume VI providing such an overview was included into the series to make this series self-sufficient in its coverage of the field of Isotope Hydrology. A special chapter on the methodologies and concepts related to geochemical modelling in groundwater systems would have been most desirable to include. The reader is referred to IAEA-TECDOC-910 and other relevant publications for guidance in this specific field

  14. Modelling

    DEFF Research Database (Denmark)

    Jessen, Britta Eyrich; Kjeldsen, Tinne Hoff; Winsløw, Carl

    Mathematical Competence Theory and the Anthropological Theory of the Didactic each offer different frameworks for the analysis and design of “modelling” as a central component of mathematics teaching. Based on two comparable cases from each research programme, we investigate how these differences...

  15. Bayesian mixture models for source separation in MEG

    International Nuclear Information System (INIS)

    This paper discusses the problem of imaging electromagnetic brain activity from measurements of the induced magnetic field outside the head. This imaging modality, magnetoencephalography (MEG), is known to be severely ill posed, and in order to obtain useful estimates for the activity map, complementary information needs to be used to regularize the problem. In this paper, a particular emphasis is on finding non-superficial focal sources that induce a magnetic field that may be confused with noise due to external sources and with distributed brain noise. The data are assumed to come from a mixture of a focal source and a spatially distributed possibly virtual source; hence, to differentiate between those two components, the problem is solved within a Bayesian framework, with a mixture model prior encoding the information that different sources may be concurrently active. The mixture model prior combines one density that favors strongly focal sources and another that favors spatially distributed sources, interpreted as clutter in the source estimation. Furthermore, to address the challenge of localizing deep focal sources, a novel depth sounding algorithm is suggested, and it is shown with simulated data that the method is able to distinguish between a signal arising from a deep focal source and a clutter signal. (paper)

  16. Mental imagery of speech and movement implicates the dynamics of internal forward models

    Directory of Open Access Journals (Sweden)

    DavidPoeppel

    2010-10-01

    Full Text Available The classical concept of efference copies in the context of internal forward models has stimulated productive research in cognitive science and neuroscience. There are compelling reasons to argue for such a mechanism, but finding direct evidence in the human brain remains difficult. Here we investigate the dynamics of internal forward models from an unconventional angle: mental imagery, assessed while recording high temporal resolution neuronal activity using magnetoencephalography (MEG. We compare two overt and covert tasks; our covert, mental imagery tasks are unconfounded by overt input/output demands – but in turn necessitate the development of appropriate multi-dimensional topographic analyses. Finger tapping (studies 1-2 and speech experiments (studies 3-5 provide temporally constrained results that implicate the estimation of an efference copy. We suggest that one internal forward model over parietal cortex subserves the kinesthetic feeling in motor imagery. Secondly, observed auditory neural activity ~170 ms after motor estimation in speech experiments (studies 3-5 demonstrates the anticipated auditory consequences of planned motor commands in a second internal forward model in imagery of speech production. Our results provide neurophysiological evidence from the human brain in favor of internal forward models deploying efference copies in somatosensory and auditory cortex, in finger tapping and speech production tasks, respectively, and also suggest the dynamics and sequential updating structure of internal forward models.

  17. Modeling

    International Nuclear Information System (INIS)

    Slurry flows occur in many circumstances, including chemical manufacturing processes, pipeline transfer of coal, sand, and minerals; mud flows; and disposal of dredged materials. In this section we discuss slurry flow applications related to radioactive waste management. The Hanford tank waste solids and interstitial liquids will be mixed to form a slurry so it can be pumped out for retrieval and treatment. The waste is very complex chemically and physically. The ARIEL code is used to model the chemical interactions and fluid dynamics of the waste

  18. Mathematical framework for large-scale brain network modeling in The Virtual Brain.

    Science.gov (United States)

    Sanz-Leon, Paula; Knock, Stuart A; Spiegler, Andreas; Jirsa, Viktor K

    2015-05-01

    In this article, we describe the mathematical framework of the computational model at the core of the tool The Virtual Brain (TVB), designed to simulate collective whole brain dynamics by virtualizing brain structure and function, allowing simultaneous outputs of a number of experimental modalities such as electro- and magnetoencephalography (EEG, MEG) and functional Magnetic Resonance Imaging (fMRI). The implementation allows for a systematic exploration and manipulation of every underlying component of a large-scale brain network model (BNM), such as the neural mass model governing the local dynamics or the structural connectivity constraining the space time structure of the network couplings. Here, a consistent notation for the generalized BNM is given, so that in this form the equations represent a direct link between the mathematical description of BNMs and the components of the numerical implementation in TVB. Finally, we made a summary of the forward models implemented for mapping simulated neural activity (EEG, MEG, sterotactic electroencephalogram (sEEG), fMRI), identifying their advantages and limitations. PMID:25592995

  19. Multi-area neural mass modeling of EEG and MEG signals.

    Science.gov (United States)

    Babajani-Feremi, Abbas; Soltanian-Zadeh, Hamid

    2010-09-01

    We previously proposed an integrated electroencephalography (EEG), magnetoencephalography (MEG), and functional Magnetic Resonance Imaging (fMRI) model based on an extended neural mass model (ENMM) within a single cortical area. In the ENMM, a cortical area contains several minicolumns where strengths of their connections diminish exponentially with their distances. The ENMM was derived based on the physiological principles of the cortical minicolumns and their connections within a single cortical area to generate EEG, MEG, and fMRI signals. The purpose of this paper is to further extend the ENMM model from a single-area to a multi-area model to develop a neural mass model of the entire brain that generates EEG and MEG signals. For multi-area modeling, two connection types are considered: short-range connections (SRCs) and long-range connections (LRCs). The intra-area SRCs among the minicolumns within the areas were previously modeled in the ENMM. To define inter-area LRCs among the cortical areas, we consider that the cell populations of all minicolumns in the destination area are affected by the excitatory afferent of the pyramidal cells of all minicolumns in the source area. The state-space representation of the multi-area model is derived considering the intra-minicolumn, SRCs', and LRCs' parameters. Using simulations, we evaluate effects of parameters of the model on its dynamics and, based on stability analysis, find valid ranges for parameters of the model. In addition, we evaluate reducing redundancy of the model parameters using simulation results and conclude that the parameters of the model can be limited to the LRCs and SRCs while the intra-minicolumn parameters stay at their physiological mean values. The proposed multi-area integrated E/MEG model provides an efficient neuroimaging technique for effective connectivity analysis in healthy subjects as well as neurological and psychiatric patients. PMID:20080193

  20. Robust decoding of selective auditory attention from MEG in a competing-speaker environment via state-space modeling.

    Science.gov (United States)

    Akram, Sahar; Presacco, Alessandro; Simon, Jonathan Z; Shamma, Shihab A; Babadi, Behtash

    2016-01-01

    The underlying mechanism of how the human brain solves the cocktail party problem is largely unknown. Recent neuroimaging studies, however, suggest salient temporal correlations between the auditory neural response and the attended auditory object. Using magnetoencephalography (MEG) recordings of the neural responses of human subjects, we propose a decoding approach for tracking the attentional state while subjects are selectively listening to one of the two speech streams embedded in a competing-speaker environment. We develop a biophysically-inspired state-space model to account for the modulation of the neural response with respect to the attentional state of the listener. The constructed decoder is based on a maximum a posteriori (MAP) estimate of the state parameters via the Expectation Maximization (EM) algorithm. Using only the envelope of the two speech streams as covariates, the proposed decoder enables us to track the attentional state of the listener with a temporal resolution of the order of seconds, together with statistical confidence intervals. We evaluate the performance of the proposed model using numerical simulations and experimentally measured evoked MEG responses from the human brain. Our analysis reveals considerable performance gains provided by the state-space model in terms of temporal resolution, computational complexity and decoding accuracy. PMID:26436490

  1. Differences between MEG and high-density EEG source localizations using a distributed source model in comparison to fMRI.

    Science.gov (United States)

    Klamer, Silke; Elshahabi, Adham; Lerche, Holger; Braun, Christoph; Erb, Michael; Scheffler, Klaus; Focke, Niels K

    2015-01-01

    Electroencephalography (EEG) and magnetoencephalography (MEG) are widely used to localize brain activity and their spatial resolutions have been compared in several publications. While most clinical studies demonstrated higher accuracy of MEG source localization, simulation studies suggested a more accurate EEG than MEG localization for the same number of channels. However, studies comparing real MEG and EEG data with equivalent number of channels are scarce. We investigated 14 right-handed healthy subjects performing a motor task in MEG, high-density-(hd-) EEG and fMRI as well as a somatosensory task in MEG and hd-EEG and compared source analysis results of the evoked brain activity between modalities with different head models. Using individual head models, hd-EEG localized significantly closer to the anatomical reference point obtained by fMRI than MEG. Source analysis results were least accurate for hd-EEG based on a standard head model. Further, hd-EEG and MEG localized more medially than fMRI. Localization accuracy of electric source imaging is dependent on the head model used with more accurate results obtained with individual head models. If this is taken into account, EEG localization can be more accurate than MEG localization for the same number of channels. PMID:25296614

  2. A slender-body micromechanical model for viscoelasticity of magnetic colloids: comparison with preliminary experimental data.

    Science.gov (United States)

    de Vicente, J; López-López, M T; Durán, J D G; Bossis, G

    2005-02-01

    The storage modulus, G', together with the yield stress, is an essential quantity characterizing the rheological properties of magnetic field-responsive suspensions (magnetorheological fluids or MRF). In this work, we present both experimental and theoretical results on the viscoelastic properties of MRFs. Two MRFs are used: In one the solid phase consists of cobalt ferrite particles + silica gel, with silicone oil as liquid phase. The second system is formed by carbonyl iron + silica gel also dispersed in silicone oil. The cobalt ferrite particles are synthesized as monodisperse colloidal spheres with an average diameter of 850 nm. We describe a new model based on the slender-body approach for hydrodynamic interactions. The predictions of the model are compared to preliminary experimental G' data obtained in a controlled stress plate-plate rheometer. It is found that the model gives the correct order of magnitude for the highest fields in iron suspensions, but underestimates the experimental results obtained in ferrite ones. In the case of high permeability materials such as carbonyl iron, by the inclusion of high-order multipolar interactions and saturation effects we also predict the order of magnitude of the experimental results. When dealing with low permeability cobalt ferrite based MRFs, other effects, such as remanence (at low fields) and saturation (at high fields), must be considered. PMID:15576099

  3. Bayesian multi-dipole modelling of a single topography in MEG by adaptive sequential Monte Carlo samplers

    International Nuclear Information System (INIS)

    In this paper, we develop a novel Bayesian approach to the problem of estimating neural currents in the brain from a fixed distribution of magnetic field (called topography), measured by magnetoencephalography. Differently from recent studies that describe inversion techniques, such as spatio-temporal regularization/filtering, in which neural dynamics always plays a role, we face here a purely static inverse problem. Neural currents are modelled as an unknown number of current dipoles, whose state space is described in terms of a variable-dimension model. Within the resulting Bayesian framework, we set up a sequential Monte Carlo sampler to explore the posterior distribution. An adaptation technique is employed in order to effectively balance the computational cost and the quality of the sample approximation. Then, both the number and the parameters of the unknown current dipoles are simultaneously estimated. The performance of the method is assessed by means of synthetic data, generated by source configurations containing up to four dipoles. Eventually, we describe the results obtained by analysing data from a real experiment, involving somatosensory evoked fields, and compare them to those provided by three other methods. (paper)

  4. An asymmetric jet-launching model for the protoplanetary nebula CRL 618

    Energy Technology Data Exchange (ETDEWEB)

    Velázquez, Pablo F.; Raga, Alejandro C.; Toledo-Roy, Juan C. [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Apdo. Postal 70-543, C.P. 04510 D.F. (Mexico); Riera, Angels, E-mail: pablo@nucleares.unam.mx [Departament de Física i Enginyeria Nuclear, EUETIB, Universitat Politècnica de Catalunya, Comte d' Urgell 187, E-08036 Barcelona (Spain)

    2014-10-20

    We propose an asymmetrical jet-ejection mechanism in order to model the mirror symmetry observed in the lobe distribution of some protoplanetary nebulae (pPNs), such as the pPN CRL 618. Three-dimensional hydrodynamical simulations of a precessing jet launched from an orbiting source were carried out, including an alternation in the ejections of the two outflow lobes, depending on which side of the precessing accretion disk is hit by the accretion column from a Roche lobe-filling binary companion. Both synthetic optical emission maps and position-velocity diagrams were obtained from the numerical results with the purpose of carrying out a direct comparison with observations. Depending on the observer's point of view, multipolar morphologies are obtained that exhibit a mirror symmetry at large distances from the central source. The obtained lobe sizes and their spatial distributions are in good agreement with the observed morphology of the pPN CRL 618. We also obtain that the kinematic ages of the fingers are similar to those obtained in the observations.

  5. Internal conversion coefficients in the Hartree-Fock atomic model. Calculations and experiments for 199Hg

    International Nuclear Information System (INIS)

    The internal conversion coefficients were calculated for the transitions in 199Hg using both Hartree-Fock and Hartree-Fock-Slater atomic models. The relative conversion line intensities were measured with the magnetic spectrometers in Prague and Heidelberg. The multipolarities were determined to be: M1 + (0.20 +- 0.03)% E2, pure E2 and M1 + (13.4 +- 0.4)% E2 for the 50, 158 and 208 keV transitions, respectively. Allowing for the nuclear structure effect in M1 component we obtained: M1 + (0.15 +- 0.03)% E2, lambda = 2.4 +- 1.0 for the 50 keV and M1 + (10.9 +- 0.7)% E2, lambda = 3.8 +- 0.5 for the 208 keV transitions. Very good agreement was found between theory and experiment for the atomic subshells, K, Lsub(1-3), Msub(1-5), N, and O + P. (orig.)

  6. Triphenylphosphonium Cations of the Diterpenoid Isosteviol: Synthesis and Antimitotic Activity in a Sea Urchin Embryo Model.

    Science.gov (United States)

    Strobykina, Irina Yu; Belenok, Mayya G; Semenova, Marina N; Semenov, Victor V; Babaev, Vasiliy M; Rizvanov, Ildar Kh; Mironov, Vladimir F; Kataev, Vladimir E

    2015-06-26

    A series of novel triphenylphosphonium (TPP) cations of the diterpenoid isosteviol (1, 16-oxo-ent-beyeran-19-oic acid) have been synthesized and evaluated in an in vivo phenotypic sea urchin embryo assay for antimitotic activity. The TPP moiety was applied as a carrier to provide selective accumulation of a connected compound into mitochondria. When applied to fertilized eggs, the targeted isosteviol TPP conjugates induced mitotic arrest with the formation of aberrant multipolar mitotic spindles, whereas both isosteviol and the methyltriphenylphosphonium cation were inactive. The structure-activity relationship study revealed the essential role of the TPP group for the realization of the isosteviol effect, while the chemical structure and the length of the linker only slightly influenced the antimitotic potency. The results obtained using the sea urchin embryo model suggested that TPP conjugates of isosteviol induced mitotic spindle defects and mitotic arrest presumably by affecting mitochondrial DNA. Since targeting mitochondria is considered as an encouraging strategy for cancer therapy, TPP-isosteviol conjugates may represent promising candidates for further design as anticancer agents. PMID:26042548

  7. Detecting single-trial EEG evoked potential using a wavelet domain linear mixed model: application to error potentials classification

    Science.gov (United States)

    Spinnato, J.; Roubaud, M.-C.; Burle, B.; Torrésani, B.

    2015-06-01

    Objective. The main goal of this work is to develop a model for multisensor signals, such as magnetoencephalography or electroencephalography (EEG) signals that account for inter-trial variability, suitable for corresponding binary classification problems. An important constraint is that the model be simple enough to handle small size and unbalanced datasets, as often encountered in BCI-type experiments. Approach. The method involves the linear mixed effects statistical model, wavelet transform, and spatial filtering, and aims at the characterization of localized discriminant features in multisensor signals. After discrete wavelet transform and spatial filtering, a projection onto the relevant wavelet and spatial channels subspaces is used for dimension reduction. The projected signals are then decomposed as the sum of a signal of interest (i.e., discriminant) and background noise, using a very simple Gaussian linear mixed model. Main results. Thanks to the simplicity of the model, the corresponding parameter estimation problem is simplified. Robust estimates of class-covariance matrices are obtained from small sample sizes and an effective Bayes plug-in classifier is derived. The approach is applied to the detection of error potentials in multichannel EEG data in a very unbalanced situation (detection of rare events). Classification results prove the relevance of the proposed approach in such a context. Significance. The combination of the linear mixed model, wavelet transform and spatial filtering for EEG classification is, to the best of our knowledge, an original approach, which is proven to be effective. This paper improves upon earlier results on similar problems, and the three main ingredients all play an important role.

  8. Cyclic Evolution of Coronal Fields from a Coupled Dynamo Potential-Field Source-Surface Model

    Science.gov (United States)

    Dikpati, Mausumi; Suresh, Akshaya; Burkepile, Joan

    2015-12-01

    The structure of the Sun's corona varies with the solar-cycle phase, from a near spherical symmetry at solar maximum to an axial dipole at solar minimum. It is widely accepted that the large-scale coronal structure is governed by magnetic fields that are most likely generated by dynamo action in the solar interior. In order to understand the variation in coronal structure, we couple a potential-field source-surface model with a cyclic dynamo model. In this coupled model, the magnetic field inside the convection zone is governed by the dynamo equation; these dynamo-generated fields are extended from the photosphere to the corona using a potential-field source-surface model. Assuming axisymmetry, we take linear combinations of associated Legendre polynomials that match the more complex coronal structures. Choosing images of the global corona from the Mauna Loa Solar Observatory at each Carrington rotation over half a cycle (1986 - 1991), we compute the coefficients of the associated Legendre polynomials up to degree eight and compare with observations. We show that at minimum the dipole term dominates, but it fades as the cycle progresses; higher-order multipolar terms begin to dominate. The amplitudes of these terms are not exactly the same for the two limbs, indicating that there is a longitude dependence. While both the 1986 and the 1996 minimum coronas were dipolar, the minimum in 2008 was unusual, since there was a substantial departure from a dipole. We investigate the physical cause of this departure by including a North-South asymmetry in the surface source of the magnetic fields in our flux-transport dynamo model, and find that this asymmetry could be one of the reasons for departure from the dipole in the 2008 minimum.

  9. The Mutliple Lobes and Geometric Model of Hubble 12: A Young Planetary Nebula with two pairs of H2 Knots

    Science.gov (United States)

    Hsia, Chih-Hao; Chau, Wayne; Zhang, Yong; Kwok, Sun

    2015-08-01

    Hubble 12 (Hb 12) is a member of the rare group of planetary nebulae (PNs) exhibiting nested shells. Its intrinsic structures and shaping mechanism are still not fully understood. We present new near-infrared narrow-band imaging observations of Hb 12 using Wide-field InfraRed Camera on the Canada-France-Hawaii Telescope (CFHT). Combining Hubble Space Telescope optical imaging and CFHT observations, we find a number of co-axial rings aligned with the bipolar lobes and two pairs of separate knots with different orientations. These rings are thought to be the manifestation of a time-variable, collimated fast wind of bipolar lobes interacting with surrounding asymptotic giant branch circumstellar medium. The existence of knots with different orientations suggests that this PN hosts a bipolar, rotating, episodic jet (BRET). We construct a three-dimensional model that allows the visualization of the nebula viewed from different orientations, and infer that this PN might have intrinsic structures similar to the young multipolar PNs, Hen 2-320 and M 2-9.

  10. Weighted minimum-norm source estimation of magnetoencephalography utilizing the temporal information of the measured data

    Science.gov (United States)

    Iwaki, Sunao; Ueno, Shoogo

    1998-06-01

    The weighted minimum-norm estimation (wMNE) is a popular method to obtain the source distribution in the human brain from magneto- and electro- encephalograpic measurements when detailed information about the generator profile is not available. We propose a method to reconstruct current distributions in the human brain based on the wMNE technique with the weighting factors defined by a simplified multiple signal classification (MUSIC) prescanning. In this method, in addition to the conventional depth normalization technique, weighting factors of the wMNE were determined by the cost values previously calculated by a simplified MUSIC scanning which contains the temporal information of the measured data. We performed computer simulations of this method and compared it with the conventional wMNE method. The results show that the proposed method is effective for the reconstruction of the current distributions from noisy data.

  11. The Nature of Abstract Orthographic Codes: Evidence from Masked Priming and Magnetoencephalography

    OpenAIRE

    Pylkkänen, Liina; Okano, Kana

    2010-01-01

    What kind of mental objects are letters? Research on letter perception has mainly focussed on the visual properties of letters, showing that orthographic representations are abstract and size/shape invariant. But given that letters are, by definition, mappings between symbols and sounds, what is the role of sound in orthographic representation? We present two experiments suggesting that letters are fundamentally sound-based representations. To examine the role of sound in orthographic represe...

  12. The nature of abstract orthographic codes: evidence from masked priming and magnetoencephalography.

    Science.gov (United States)

    Pylkkänen, Liina; Okano, Kana

    2010-01-01

    What kind of mental objects are letters? Research on letter perception has mainly focussed on the visual properties of letters, showing that orthographic representations are abstract and size/shape invariant. But given that letters are, by definition, mappings between symbols and sounds, what is the role of sound in orthographic representation? We present two experiments suggesting that letters are fundamentally sound-based representations. To examine the role of sound in orthographic representation, we took advantage of the multiple scripts of Japanese. We show two types of evidence that if a Japanese word is presented in a script it never appears in, this presentation immediately activates the ("actual") visual word form of that lexical item. First, equal amounts of masked repetition priming are observed for full repetition and when the prime appears in an atypical script. Second, visual word form frequency affects neuromagnetic measures already at 100-130 ms whether the word is presented in its conventional script or in a script it never otherwise appears in. This suggests that Japanese orthographic codes are not only shape-invariant, but also script invariant. The finding that two characters belonging to different writing systems can activate the same form representation suggests that sound identity is what determines orthographic identity: as long as two symbols express the same sound, our minds represent them as part of the same character/letter. PMID:20520833

  13. Aberrant Neuromagnetic Activation in the Motor Cortex in Children with Acute Migraine: A Magnetoencephalography Study

    OpenAIRE

    Guo, Xinyao; Xiang, Jing; Wang, Yingying; O’Brien, Hope; Kabbouche, Marielle; Horn, Paul; Powers, Scott W; Hershey, Andrew D.

    2012-01-01

    Migraine attacks have been shown to interfere with normal function in the brain such as motor or sensory function. However, to date, there has been no clinical neurophysiology study focusing on the motor function in children with migraine during headache attacks. To investigate the motor function in children with migraine, twenty-six children with acute migraine, meeting International Classification of Headache Disorders criteria and age- and gender-matched healthy children were studied using...

  14. Development of Theory of Mind Stimuli in Magnetoencephalography for Nursing Evaluation

    Directory of Open Access Journals (Sweden)

    Sungwon Park

    2009-09-01

    Full Text Available We introduce the development of animation stimuli for theory of mind (ToM in magnetoencepalography (MEG. We will discuss apparatus for presenting animation stimuli and a technical problem like an eye movement signal generated from following triangles in the animations, and its rejection using independent component analysis (ICA. With the ToM animations and the apparatus, we conducted MEG measurements for 8 normal controls and 6 schizophrenic patients. We present a preliminary assessment result for the developed animation stimuli as a tool for ToM test, which has been obtained by scoring in the followingup interview after the MEG measurement.

  15. Direction of magnetoencephalography sources associated with feedback and feedforward contributions in a visual object recognition task.

    Science.gov (United States)

    Ahlfors, Seppo P; Jones, Stephanie R; Ahveninen, Jyrki; Hämäläinen, Matti S; Belliveau, John W; Bar, Moshe

    2015-01-12

    Identifying inter-area communication in terms of the hierarchical organization of functional brain areas is of considerable interest in human neuroimaging. Previous studies have suggested that the direction of magneto- and electroencephalography (MEG, EEG) source currents depend on the layer-specific input patterns into a cortical area. We examined the direction in MEG source currents in a visual object recognition experiment in which there were specific expectations of activation in the fusiform region being driven by either feedforward or feedback inputs. The source for the early non-specific visual evoked response, presumably corresponding to feedforward driven activity, pointed outward, i.e., away from the white matter. In contrast, the source for the later, object-recognition related signals, expected to be driven by feedback inputs, pointed inward, toward the white matter. Associating specific features of the MEG/EEG source waveforms to feedforward and feedback inputs could provide unique information about the activation patterns within hierarchically organized cortical areas. PMID:25445356

  16. Functional connectivity changes detected with magnetoencephalography after mild traumatic brain injury

    Directory of Open Access Journals (Sweden)

    Stavros I. Dimitriadis

    2015-01-01

    Full Text Available Mild traumatic brain injury (mTBI may affect normal cognition and behavior by disrupting the functional connectivity networks that mediate efficient communication among brain regions. In this study, we analyzed brain connectivity profiles from resting state Magnetoencephalographic (MEG recordings obtained from 31 mTBI patients and 55 normal controls. We used phase-locking value estimates to compute functional connectivity graphs to quantify frequency-specific couplings between sensors at various frequency bands. Overall, normal controls showed a dense network of strong local connections and a limited number of long-range connections that accounted for approximately 20% of all connections, whereas mTBI patients showed networks characterized by weak local connections and strong long-range connections that accounted for more than 60% of all connections. Comparison of the two distinct general patterns at different frequencies using a tensor representation for the connectivity graphs and tensor subspace analysis for optimal feature extraction showed that mTBI patients could be separated from normal controls with 100% classification accuracy in the alpha band. These encouraging findings support the hypothesis that MEG-based functional connectivity patterns may be used as biomarkers that can provide more accurate diagnoses, help guide treatment, and monitor effectiveness of intervention in mTBI.

  17. Functional connectivity changes detected with magnetoencephalography after mild traumatic brain injury

    Science.gov (United States)

    Dimitriadis, Stavros I.; Zouridakis, George; Rezaie, Roozbeh; Babajani-Feremi, Abbas; Papanicolaou, Andrew C.

    2015-01-01

    Mild traumatic brain injury (mTBI) may affect normal cognition and behavior by disrupting the functional connectivity networks that mediate efficient communication among brain regions. In this study, we analyzed brain connectivity profiles from resting state Magnetoencephalographic (MEG) recordings obtained from 31 mTBI patients and 55 normal controls. We used phase-locking value estimates to compute functional connectivity graphs to quantify frequency-specific couplings between sensors at various frequency bands. Overall, normal controls showed a dense network of strong local connections and a limited number of long-range connections that accounted for approximately 20% of all connections, whereas mTBI patients showed networks characterized by weak local connections and strong long-range connections that accounted for more than 60% of all connections. Comparison of the two distinct general patterns at different frequencies using a tensor representation for the connectivity graphs and tensor subspace analysis for optimal feature extraction showed that mTBI patients could be separated from normal controls with 100% classification accuracy in the alpha band. These encouraging findings support the hypothesis that MEG-based functional connectivity patterns may be used as biomarkers that can provide more accurate diagnoses, help guide treatment, and monitor effectiveness of intervention in mTBI. PMID:26640764

  18. Tinnitus perception and distress is related to abnormal spontaneous brain activity as measured by magnetoencephalography.

    Directory of Open Access Journals (Sweden)

    2005-06-01

    Full Text Available BACKGROUND: The neurophysiological mechanisms underlying tinnitus perception are not well understood. Surprisingly, there have been no group studies comparing abnormalities in ongoing, spontaneous neuronal activity in individuals with and without tinnitus perception. METHODS AND FINDINGS: Here, we show that the spontaneous neuronal activity of a group of individuals with tinnitus (n = 17 is characterised by a marked reduction in alpha (8-12 Hz power together with an enhancement in delta (1.5-4 Hz as compared to a normal hearing control group (n = 16. This pattern was especially pronounced for temporal regions. Moreover, correlations with tinnitus-related distress revealed strong associations with this abnormal spontaneous activity pattern, particularly in right temporal and left frontal areas. Overall, effects were stronger for the alpha than for the delta frequency band. A data stream of 5 min, recorded with a whole-head neuromagnetometer under a resting condition, was sufficient to extract the marked differences. CONCLUSIONS: Despite some limitations, there are arguments that the regional pattern of abnormal spontaneous activity we found could reflect a tinnitus-related cortical network. This finding, which suggests that a neurofeedback approach could reduce the adverse effects of this disturbing condition, could have important implications for the treatment of tinnitus.

  19. Spatially sparse source cluster modeling by Compressive Neuromagnetic Tomography

    OpenAIRE

    Chang, Wei-Tang; Nummenmaa, Aapo; Lin, Fa-Hsuan

    2010-01-01

    Magnetoencephalography enables non-invasive detection of weak cerebral magnetic fields by utilizing super-conducting quantum interference devices (SQUIDs). Solving the MEG inverse problem requires reconstructing the locations and orientations of the underlying neuronal current sources based on the extracranial measurements. Most inverse problem solvers explicitly favor either spatially more focal or diffuse current source patterns. Naturally, in a situation where both focal and spatially exte...

  20. Pathological documentation of complete elimination of Barrett's metaplasia following endoscopic multipolar electrocoagulation therapy

    OpenAIRE

    Fennerty, M; Corless, C.; Sheppard, B; Faigel, D.; Lieberman, D.; Sampliner, R

    2001-01-01

    The previous paradigm that Barrett's is an irreversible premalignant lesion has recently been challenged by a proliferation of reports documenting elimination of Barrett's by a variety of endoscopic techniques. Whether Barrett's is entirely eliminated is unknown as endoscopic biopsy samples the surface of the epithelium only. Numerous reports document underlying specialised columnar epithelium in many of these trials. Until now there have been no reports of pathological examination of the ent...

  1. Multi-Polarization ASAR Backscattering from Herbaceous Wetlands in Poyang Lake Region, China

    OpenAIRE

    Huiyong Sang; Jixian Zhang; Hui Lin; Liang Zhai

    2014-01-01

    Wetlands are one of the most important ecosystems on Earth. There is an urgent need to quantify the biophysical parameters (e.g., plant height, aboveground biomass) and map total remaining areas of wetlands in order to evaluate the ecological status of wetlands. In this study, Environmental Satellite/Advanced Synthetic Aperture Radar (ENVISAT/ASAR) dual-polarization C-band data acquired in 2005 is tested to investigate radar backscattering mechanisms with the variation of hydrological conditi...

  2. Energetic diplomacy and its role on creation of a new multipolar world

    Directory of Open Access Journals (Sweden)

    Igor Gelev

    2016-01-01

    Many of us would ask does this mean the reincarnation of the so called almost forgotten Cold War only now coming in such a shape that seems to be far more terrifying in character with a great deal of chance to impose the brink of a new world war and another humanitarian wash-out to humanity.

  3. Energetic diplomacy and its role on creation of a new multipolar world

    OpenAIRE

    Igor Gelev; Muhamet Racaj

    2016-01-01

    International correlations through the last years have been remarked as dramatic in character, and very often followed through with unpredictable events, such as the Arab spring, chronic and confessional wars raging through the Middle east, than the unprincipled informal collation of the great forces merging with variety and different in character formal and less formal state-of-actors, than worth mentioning is the recent war prelude in Ukraine which on top has all been spiced and made far mo...

  4. Effect of multipolar interaction on the effective thermal conductivity of nanofluids

    Science.gov (United States)

    Zhou, Xiao-Feng; Gao, Lei

    2007-07-01

    Nanofluids or liquids with suspended nanoparticles are likely to be the future heat transfer media, as they exhibit higher thermal conductivity than those of liquids. It has been proposed that nanoparticles are apt to congregate and form clusters, and hence the interaction between nanoparticles becomes important. In this paper, by taking into account the interaction between nearest-neighbour inclusions, we adopt the multiple image method to investigate the effective thermal conductivity of nanofluids. Numerical results show that then the thermal conductivity ratio between the nanoparticles and fluids is large, and the two nanoparticles are close up and even touch, and the point-dipole theory such as Maxwell-Garnett theory becomes rough as many-body interactions are neglected. Our theoretical results on the effective thermal conductivity of CuO/water and Al2O3/water nanofluids are in good agreement with experimental data.

  5. Multipolar Force Fields and Their Effects on Solvent Dynamics around Simple Solutes

    DEFF Research Database (Denmark)

    Jakobsen, Sofie; Bereau, Tristan; Meuwly, Markus

    2015-01-01

    The performance of multipole (MTP) and point charge (PC) force fields in classical molecular dynamics (MD) simulations of condensed-phase systems for both equilibrium and dynamical quantities is compared. MTP electrostatics provides an improved description of the anisotropic electrostatic potential, which is especially important to describe key, challenging interactions, such as lone pairs, ?-interactions, and hydrogen bonds. These chemical environments are probed by focusing on the hydration pr...

  6. Internal conversion of high-multipolarity transitions in 109Ag and 113In

    International Nuclear Information System (INIS)

    The internal conversion coefficients were measured for the 88.032 keV E3 transition in 109Ag using the 4π pressurized proportional counter, the windowless 4π scintillation counter and the double-focusing magnetic spectrometer. The results are: αsub(T) = 26.4 +- 0.4, αsub(K) = 11.4 +- 0.3, αsub(L1) = 0.63 +- 0.13, αsub(L2) = 5.48 +- 0.18, αsub(L3) = 6.11 +- 0.20, αsub(M) = 2.40 +- 0.08, αsub(NO) = 0.405 +- 0.021. The theoretical conversion coefficients were calculated for this transition and for the 391.69 keV M4 transition in 113In and were found to be in agreement with the experiment. (orig.)

  7. Study of H- production in H2 microwave multipolar plasmas by optical and electrical diagnostics

    International Nuclear Information System (INIS)

    A way to achieve heating is the injection in the plasma of highly energetic particles (? MeV) that will transfer their energy during collisions. For this purpose, energetic charged particles are independently created in D2 plasmas and then neutralized so they can penetrate into the tokamak without being sensitive to the magnetic confinement. Neutral beam injection can deliver up to 16 MW into the ITER plasma. D- beams are used rather than D+ as the neutralisation of the latter is almost zero instead of 60% for D-, at the energy of interest. In this framework, our work is devoted to the production of H- negative ions from H2 microwave multi-dipolar plasmas. Negative ions are produced inside the plasma volume by dissociative electron attachment to highly vibrationally-excited molecules H2 (step 3). They can also be produced throughout plasma-surface interactions, where H atoms created in the plasma volume stick on the material (step 1) and recombine with hydrogen present on the surface, resulting in the desorption of a vibrationally-excited H2 molecule (step 2), which reacts with a cold electron to form a negative ion (step 3). Plasma diagnostics are implemented to better understand the mechanisms involved in H production. Step 3 is studied by means of Langmuir probes for electron density and energy distribution measurements, while laser photo-detachment (Nd-YAG, 1064 nm) gives negative ion densities. H atom densities are followed by Optical Emission Spectroscopy (OES) using actinometry, as well as Laser Induced Fluorescence with one (LIF) or two (TALIF) photons. By generating H atom spatial profiles via Abel transform, we try to differentiate volume mechanisms from surface ones. This document is composed of a short paper followed by a poster

  8. Multipolarities of nuclear transitions involved in the one neutron disintegration of /sup 238/U

    Energy Technology Data Exchange (ETDEWEB)

    Martins, M.N.; Wolynec, E.; Moscati, G.

    1977-08-01

    Measurements of the electrodisintegration cross section /sup 238/U(e,e',n)/sup 237/U in the energy region 6--25 MeV are presented. A virtual photon analysis of experimental data shows that neutron emission occurs only through E1 absorption. Our data establish an upper limit to the strength of E2 transitions, which is only 0.25% of the E1 transitions. Existing data on the decay channels of the isoscalar giant quadrupole resonance in /sup 238/U are compared with available data on E2 absorption by this nucleus. A discussion of available experimental data indicating a selectivity of decay modes on the spin and parity of the excited resonance is presented. The sensitivity of electrodisintegration cross sections to the existence of quadrupole components is assessed.

  9. Multipolarities of nuclear transitions involved in the one neutron disintegration of 238U

    International Nuclear Information System (INIS)

    Measurements of the electrodisintegration cross section 238U(e,e',n)237U in the energy region 6--25 MeV are presented. A virtual photon analysis of experimental data shows that neutron emission occurs only through E1 absorption. Our data establish an upper limit to the strength of E2 transitions, which is only 0.25% of the E1 transitions. Existing data on the decay channels of the isoscalar giant quadrupole resonance in 238U are compared with available data on E2 absorption by this nucleus. A discussion of available experimental data indicating a selectivity of decay modes on the spin and parity of the excited resonance is presented. The sensitivity of electrodisintegration cross sections to the existence of quadrupole components is assessed

  10. Multipolar permanent-magnet synchronous generators intended for wind power plants

    Science.gov (United States)

    Kovalev, L. K.; Kovalev, K. L.; Tulinova, Ye. Ye.; Ivanov, N. S.

    2012-12-01

    The analytical method of calculating two-dimensional magnetic fields in the active section of permanent-magnet synchronous electrical rotating machines, as applied to their use in the wind energy industry, has been developed. The analytical relationships for calculating distribution of two-dimensional magnetic fields and determining output parameters with due regard for geometry of the active section, the number of pairs of poles, and magnetic characteristics of materials have been obtained. The criteria dependences needed for calculating the electromotive force and main inductive reactance of permanent-magnet synchronous electric machines, with consideration for the geometry of a machine and electrophysical properties of materials being used, have been derived. The procedure of evaluating parameters of permanent-magnet synchronous generators for large-size wind power plants is presented.

  11. Microwave plasma source for ion sources with multipolar and axial magnetic fields

    International Nuclear Information System (INIS)

    A microwave (2.45 GHz) plasma source for ion sources has been constructed and its characteristics have been examined. It consists of the part of the source generating a plasma and that making the plasma uniform. The experiments have been conducted in four kinds of magnetic field configurations generated by solenoid coils and arrays of permanent magnets. The plasma parameters have been measured with a Langmuir probe located at 2 cm above a plasma grid. The uniform plasma over an area of 8?10 cm·? in diameter and the density of 2.6 x 1011 cm-3 has been produced. The magnetic field intensity near the plasma grid is nearly zero. (author)

  12. Multipolar universal relations between f-mode frequency and tidal deformability of compact stars

    CERN Document Server

    Chan, T K; Leung, P T; Lin, L -M

    2014-01-01

    Though individual stellar parameters of compact stars usually demonstrate obvious dependence on the equation of state (EOS), EOS-insensitive universal formulas relating these parameters remarkably exist. In the present paper, we explore the inter-relationship between two such formulas, namely the f-I relation connecting the $f$-mode quadrupole oscillation frequency $\\omega_2$ and the moment of inertia $I$, and the I-Love-Q relations relating $I$, the quadrupole tidal deformability $\\lambda_2$, and the quadrupole moment $Q$, which have been proposed by Lau et al. [Astrophys. J. {\\bf 714}, 1234 (2010)], and Yagi and Yunes [Science, {\\bf 341}, 365 (2013)], respectively. A relativistic universal relation between $\\omega_l$ and $\\lambda_l$ with the same angular momentum $l=2,3,\\ldots$, the so called "diagonal f-Love relation" that holds for realistic compact stars and stiff polytropic stars, is unveiled here. An in-depth investigation in the Newtonian limit is further carried out to pinpoint its underlying physica...

  13. Multipolar laminated electromagnet for low-field magnetic resonance imaging and electron paramagnetic resonance imaging.

    Science.gov (United States)

    Chiricozzi, E; Masciovecchio, C; Villani, M; Sotgiu, A; Testa, L

    1998-07-01

    A cylindrical 16-pole electromagnet (EM) for electron paramagnetic resonance imaging (EPRI) and low-field magnetic resonance imaging (MRI) has been designed by means of two-dimensional and three-dimensional (3-D) finite element analysis (FEA). The use of an automatic procedure that combines FEA with a minimization routine allowed the optimization of the design, in order to improve the homogeneity along the axis of the EM. A prototype has been built by using electrical steel sheets that were cut by laser; this solution reduced significantly the manufacturing cost. The EM operates with a maximum flux density, in the bore, of 0.08 T and has a homogeneity along the axis of about 40 parts per million (ppm) in a spherical region 10 cm in diameter. It generates the main field and two of the three field gradients required in the 3-D image reconstruction. Good agreement was found between the results of simulation and the measured values. PMID:9644902

  14. Crystal design using multipolar electrostatic interactions: A concept study for organic electronics

    Directory of Open Access Journals (Sweden)

    Peer Kirsch

    2013-11-01

    Full Text Available Using a simple synthetic protocol, heterohexacene analogues with a quadrupolar distribution of partial charges are readily available. In contrast to most other acenes, these compounds crystallize with a slipped-stack, brickwork-like packing which is mainly controlled by electrostatic interactions. This type of packing offers an advantage for organic semiconductors, because it allows more isotropic charge transport compared to the “herring bone” stacking observed for other acenes.

  15. Reshaping Europe In A Multipolar World: Can The EU Rise To The Challenge?

    Directory of Open Access Journals (Sweden)

    Dean Carroll

    2011-09-01

    Full Text Available Globalisation and the emergence of economic players such as Brazil, Russia, India and China (BRIC have led to predictions that US hegemony will quickly decline as a new world order emerges. With the European Union (EU also facing a downgrading of its own status – as economic, political and cultural power shifts from west to east – now is the time to ensure the Union has a strategy in place to remain an influential global actor despite its lack of natural resources and member state sovereign debt arising from the 2008/9 economic crisis. Only concerted efforts at institutional future-proofing (or widening and deepening plus by the EU and a global vision for the supranational body will ensure its survival and prosperity.

  16. Multi-Polarization ASAR Backscattering from Herbaceous Wetlands in Poyang Lake Region, China

    Directory of Open Access Journals (Sweden)

    Huiyong Sang

    2014-05-01

    Full Text Available Wetlands are one of the most important ecosystems on Earth. There is an urgent need to quantify the biophysical parameters (e.g., plant height, aboveground biomass and map total remaining areas of wetlands in order to evaluate the ecological status of wetlands. In this study, Environmental Satellite/Advanced Synthetic Aperture Radar (ENVISAT/ASAR dual-polarization C-band data acquired in 2005 is tested to investigate radar backscattering mechanisms with the variation of hydrological conditions during the growing cycle of two types of herbaceous wetland species, which colonize lake borders with different elevation in Poyang Lake region, China. Phragmites communis (L. Trin. is semi-aquatic emergent vegetation with vertical stem and blade-like leaves, and the emergent Carex spp. has rhizome and long leaves. In this study, the potential of ASAR data in HH-, HV-, and VV-polarization in mapping different wetland types is examined, by observing their dynamic variations throughout the whole flooding cycle. The sensitivity of ASAR backscattering coefficients to vegetation parameters of plant height, fresh and dry biomass, and vegetation water content is also analyzed for Phragmites communis (L. Trin. and Carex spp. The research for Phragmites communis (L. Trin. shows that HH polarization is more sensitive to plant height and dry biomass than HV polarization. ASAR backscattering coefficients are relatively less sensitive to fresh biomass, especially in HV polarization. However, both are highly dependent on canopy water content. In contrast, the dependence of HH- and HV- backscattering from Carex community on vegetation parameters is poor, and the radar backscattering mechanism is controlled by ground water level.

  17. Treatment of atrial fibrillation with radiofrequency ablation and simultaneous multipolar mapping of the pulmonary veins

    Directory of Open Access Journals (Sweden)

    Rocha Neto Almino C.

    2001-01-01

    Full Text Available OBJECTIVE: To demonstrate the feasibility and safety of simultaneous catheterization and mapping of the 4 pulmonary veins for ablation of atrial fibrillation. METHODS: Ten patients, 8 with paroxysmal atrial fibrillation and 2 with persistent atrial fibrillation, refractory to at least 2 antiarrhythmic drugs and without structural cardiopathy, were consecutively studied. Through the transseptal insertion of 2 long sheaths, 4 pulmonary veins were simultaneously catheterized with octapolar microcatheters. After identification of arrhythmogenic foci radiofrequency was applied under angiographic or ultrasonographic control. RESULTS: During 17 procedures, 40 pulmonary veins were mapped, 16 of which had local ectopic activity, related or not with the triggering of atrial fibrillation paroxysms. At the end of each procedure, suppression of arrhythmias was obtained in 8 patients, and elimination of pulmonary vein potentials was accomplished in 4. During the clinical follow-up of 9.6±3 months, 7 patients remained in sinus rhythm, 5 of whom were using antiarrhythmic drugs that had previously been ineffective. None of the patients had pulmonary hypertension or evidence of stenosis in the pulmonary veins. CONCLUSION: Selective and simultaneous catheterization of the 4 pulmonary veins with microcatheters for simultaneous recording of their electrical activity is a feasible and safe procedure that may help ablation of atrial fibrillation.

  18. Governing the Global Land Grab: Multipolarity, Ideas, and Complexity in Transnational Governance

    OpenAIRE

    Margulis, M.; Porter, T

    2013-01-01

    Since 2008, a series of new regulatory initiatives have emerged to address large-scale land grabs. These initiatives are occurring simultaneously at multiple levels of social organization instead of a single, overarching institutional site. A significant portion of this activity is taking place at the transnational level. We suggest that transnational land governance is indicative of emerging shifts in the practice of governance of global affairs. We analyze such shifts by asking two related ...

  19. Multipolar representation of Maxwell and Schroedinger equations: Lagrangian and Hamiltonian formalisms: Examples

    International Nuclear Information System (INIS)

    Development of quantum engineering put forward new theoretical problems. Behaviour of a single mesoscopic cell (device) we may usually describe by equations of quantum mechanics. However, if experimentators gather hundreds of thousands of similar cells there arises some artificial medium that one already needs to describe by means of new electromagnetic equations. The same problem arises when we try to describe e.g. a sublattice structure of such complex substances like perovskites. It is demonstrated that the inherent primacy of vector potential in quantum systems leads to a generalization of the equations of electromagnetism by introducing in them toroid polarizations. To derive the equations of motion the Lagrangian and the Hamiltonian formalisms are used. Some examples where electromagnetic properties of molecules are described by the toroid moment are pointed out. (author). 26 refs, 7 figs

  20. The impact of the new Earth gravity models on the measurement of the Lense-Thirring effect with a new satellite

    CERN Document Server

    Iorio, L

    2005-01-01

    In this paper we investigate the opportunities offered by the new Earth gravity models from the dedicated CHAMP and, especially, GRACE missions to the project of measuring the general relativistic Lense-Thirring effect with a new Earth's artificial satellite. It turns out that it would be possible to abandon the stringent, and expensive, requirements on the orbital geometry of the originally prosed LARES mission (same semimajor axis a=12270 km of the existing LAGEOS and inclination i=70 deg) by inserting the new spacecraft in a relatively low, and cheaper, orbit (a=7500-8000 km, i\\sim 70 deg) and suitably combining its node Omega with those of LAGEOS and LAGEOS II in order to cancel out the first even zonal harmonic coefficients of the multipolar expansion of the terrestrial gravitational potential J_2, J_4 along with their temporal variations. The total systematic error due to the mismodelling in the remaining even zonal harmonics would amount to \\sim 1% and would be insensitive to departures of the inclinat...

  1. Spatially sparse source cluster modeling by compressive neuromagnetic tomography.

    Science.gov (United States)

    Chang, Wei-Tang; Nummenmaa, Aapo; Hsieh, Jen-Chuen; Lin, Fa-Hsuan

    2010-10-15

    Magnetoencephalography enables non-invasive detection of weak cerebral magnetic fields by utilizing super-conducting quantum interference devices (SQUIDs). Solving the MEG inverse problem requires reconstructing the locations and orientations of the underlying neuronal current sources based on the extracranial measurements. Most inverse problem solvers explicitly favor either spatially more focal or diffuse current source patterns. Naturally, in a situation where both focal and spatially extended sources are present, such reconstruction methods may yield inaccurate estimates. To address this problem, we propose a novel ComprEssive Neuromagnetic Tomography (CENT) method based on the assumption that the current sources are compressible. The compressibility is quantified by the joint sparsity of the source representation in the standard source space and in a transformed domain. The purpose of the transformation sparsity constraint is to incorporate local spatial structure adaptively by exploiting the natural redundancy of the source configurations in the transform domain. By combining these complementary constraints of standard and transformed domain sparsity we obtain source estimates, which are not only locally smooth and regular but also form globally separable clusters. In this work, we use the l(1)-norm as a measure of sparsity and convex optimization to yield compressive estimates in a computationally tractable manner. We study the Laplacian matrix (CENT(L)) and spherical wavelets (CENT(W)) as alternatives for the transformation in the compression constraint. In addition to the two prior constraints on the sources, we control the discrepancy between the modeled and measured data by restricting the power of residual error below a specified value. The results show that both CENT(L) and CENT(W) are capable of producing robust spatially regular source estimates with high computational efficiency. For simulated sources of focal, diffuse, or combined types, the CENT method shows better accuracy on estimating the source locations and spatial extents than the minimum l(1)-norm or minimum l(2)-norm constrained inverse solutions. Different transformations yield different benefits: By utilizing CENT with the Laplacian matrix it is possible to suppress physiologically atypical activations extending across two opposite banks of a deep sulcus. With the spherical wavelet transform CENT can improve the detection of two nearby yet not directly connected sources. As demonstrated by simulations, CENT is capable of reflecting the spatial extent for both focal and spatially extended current sources. The analysis of in vivo MEG data by CENT produces less physiologically inconsistent "clutter" current sources in somatosensory and auditory MEG measurements. Overall, the CENT method is demonstrated to be a promising tool for adaptive modeling of distributed neuronal currents associated with cognitive tasks. PMID:20488248

  2. Assessment of subcortical source localization using deep brain activity imaging model with minimum norm operators: a MEG study.

    Science.gov (United States)

    Attal, Yohan; Schwartz, Denis

    2013-01-01

    Subcortical structures are involved in many healthy and pathological brain processes. It is crucial for many studies to use magnetoencephalography (MEG) to assess the ability to detect subcortical generators. This study aims to assess the source localization accuracy and to compare the characteristics of three inverse operators in the specific case of subcortical generators. MEG has a low sensitivity to subcortical sources mainly because of their distance from sensors and their complex cyto-architecture. However, we show that using a realistic anatomical and electrophysiological model of deep brain activity (DBA), the sources make measurable contributions to MEG sensors signals. Furthermore, we study the point-spread and cross-talk functions of the wMNE, sLORETA and dSPM inverse operators to characterize distortions in cortical and subcortical regions and to study how noise-normalization methods can improve or bias accuracy. We then run Monte Carlo simulations with neocortical and subcortical activations. In the case of single hippocampus patch activations, the results indicate that MEG can indeed localize the generators in the head and the body of the hippocampus with good accuracy. We then tackle the question of simultaneous cortical and subcortical activations. wMNE can detect hippocampal activations that are embedded in cortical activations that have less than double their amplitude, but it does not completely correct the bias to more superficial sources. dSPM and sLORETA can still detect hippocampal activity above this threshold, but such detection might include the creation of ghost deeper sources. Finally, using the DBA model, we showed that the detection of weak thalamic modulations of ongoing brain activity is possible. PMID:23527277

  3. Human in vitro reporter model of neuronal development and early differentiation processes

    Directory of Open Access Journals (Sweden)

    Bogdahn Ulrich

    2008-02-01

    Full Text Available Abstract Background During developmental and adult neurogenesis, doublecortin is an early neuronal marker expressed when neural stem cells assume a neuronal cell fate. To understand mechanisms involved in early processes of neuronal fate decision, we investigated cell lines for their capacity to induce expression of doublecortin upon neuronal differentiation and develop in vitro reporter models using doublecortin promoter sequences. Results Among various cell lines investigated, the human teratocarcinoma cell line NTERA-2 was found to fulfill our criteria. Following induction of differentiation using retinoic acid treatment, we observed a 16-fold increase in doublecortin mRNA expression, as well as strong induction of doublecortin polypeptide expression. The acquisition of a neuronal precursor phenotype was also substantiated by the establishment of a multipolar neuronal morphology and expression of additional neuronal markers, such as Map2, ?III-tubulin and neuron-specific enolase. Moreover, stable transfection in NTERA-2 cells of reporter constructs encoding fluorescent or luminescent genes under the control of the doublecortin promoter allowed us to directly detect induction of neuronal differentiation in cell culture, such as following retinoic acid treatment or mouse Ngn2 transient overexpression. Conclusion Induction of doublecortin expression in differentiating NTERA-2 cells suggests that these cells accurately recapitulate some of the very early events of neuronal determination. Hence, the use of reporter genes under the control of the doublecortin promoter in NTERA-2 cells will help us to investigate factors involved early in the course of neuronal differentiation processes. Moreover the ease to detect the induction of a neuronal program in this model will permit to perform high throughput screening for compounds acting on the early neuronal differentiation mechanisms.

  4. Modeling Model Slicers

    OpenAIRE

    Blouin A.; Combemale B.; Baudry B.; Beaudoux O.

    2011-01-01

    Among model comprehension tools, model slicers are tools that extract a subset from a model, for a specific purpose. Model slicers are tools that let modelers rapidly gather relevant knowledge from large models. However, existing slicers are dedicated to one modeling language. This is an issue when we observe that new domain specific modeling languages (DSMLs), for which we want slicing abilities, are created almost on a daily basis. This paper proposes the Kompren language to model and gener...

  5. How neurons migrate: a dynamic in-silico model of neuronal migration in the developing cortex

    LENUS (Irish Health Repository)

    Setty, Yaki

    2011-09-30

    Abstract Background Neuronal migration, the process by which neurons migrate from their place of origin to their final position in the brain, is a central process for normal brain development and function. Advances in experimental techniques have revealed much about many of the molecular components involved in this process. Notwithstanding these advances, how the molecular machinery works together to govern the migration process has yet to be fully understood. Here we present a computational model of neuronal migration, in which four key molecular entities, Lis1, DCX, Reelin and GABA, form a molecular program that mediates the migration process. Results The model simulated the dynamic migration process, consistent with in-vivo observations of morphological, cellular and population-level phenomena. Specifically, the model reproduced migration phases, cellular dynamics and population distributions that concur with experimental observations in normal neuronal development. We tested the model under reduced activity of Lis1 and DCX and found an aberrant development similar to observations in Lis1 and DCX silencing expression experiments. Analysis of the model gave rise to unforeseen insights that could guide future experimental study. Specifically: (1) the model revealed the possibility that under conditions of Lis1 reduced expression, neurons experience an oscillatory neuron-glial association prior to the multipolar stage; and (2) we hypothesized that observed morphology variations in rats and mice may be explained by a single difference in the way that Lis1 and DCX stimulate bipolar motility. From this we make the following predictions: (1) under reduced Lis1 and enhanced DCX expression, we predict a reduced bipolar migration in rats, and (2) under enhanced DCX expression in mice we predict a normal or a higher bipolar migration. Conclusions We present here a system-wide computational model of neuronal migration that integrates theory and data within a precise, testable framework. Our model accounts for a range of observable behaviors and affords a computational framework to study aspects of neuronal migration as a complex process that is driven by a relatively simple molecular program. Analysis of the model generated new hypotheses and yet unobserved phenomena that may guide future experimental studies. This paper thus reports a first step toward a comprehensive in-silico model of neuronal migration.

  6. A modelling study to inform specification and optimal electrode placement for imaging of neuronal depolarization during visual evoked responses by electrical and magnetic detection impedance tomography

    International Nuclear Information System (INIS)

    Electrical impedance tomography (EIT) has the potential to achieve non-invasive functional imaging of fast neuronal activity in the human brain due to opening of ion channels during neuronal depolarization. Local changes of resistance in the cerebral cortex are about 1%, but the size and location of changes recorded on the scalp are unknown. The purpose of this work was to develop an anatomically realistic finite element model of the adult human head and use it to predict the amplitude and topography of changes on the scalp, and so inform specification for an in vivo measuring system. A detailed anatomically realistic finite element (FE) model of the head was produced from high resolution MRI. Simulations were performed for impedance changes in the visual cortex during evoked activity with recording of scalp potentials by electrodes or magnetic flux density by magnetoencephalography (MEG) in response to current injected with electrodes. The predicted changes were validated by recordings in saline filled tanks and with boundary voltages measured on the human scalp. Peak changes were 1.03 ± 0.75 µV (0.0039 ± 0.0034%) and 27 ± 13 fT (0.2 ± 0.5%) respectively, which yielded an estimated peak signal-to-noise ratio of about 4 for in vivo averaging over 10 min and 1 mA current injection. The largest scalp changes were over the occipital cortex. This modelling suggests, for the first time, that reproducible changes could be recorded on the scalp in vivo in single channels, although a higher SNR would be desirable for accurate image production. The findings suggest that an in vivo study is warranted in order to determine signal size but methods to improve SNR, such as prolonged averaging or other signal processing may be needed for accurate image production

  7. 109Pd: Difficulties in particle-rotor models for unique-parity states and revision of spectroscopic factors

    International Nuclear Information System (INIS)

    Primary and secondary ? rays following thermal and p-wave resonant (2.96 eV) neutron capture on 108Pd were measured to study ?-ray transitions in 109Pd. Average resonance capture spectra at 2 and 24 keV were also recorded and the 108Pd(n,?ce) reaction was studied and transition multipolarities were deduced. A detailed level scheme up to approx. 1400 keV has been constructed. Numerous spin assignments have been revised, leading to substantial changes in the (d,p) and (d,t) spectroscopic factors, in particular for the g/sub 7/2/ orbit. The data on primary transition intensities for the 2.96 eV resonance are compared with the valence neutron capture model. The level scheme deduced for 109Pd sheds new light on the previously proposed g/sub 7/2/-h/sub 11/2/ anomaly in the filling of these orbits, suggesting that, at least in 109Pd, the appearance of the anomaly was largely due to spin misassignments. The revised systematics in the occupation of shell model orbits for a number of nuclei in this mass region is reviewed. Within the level scheme is a group of low-spin negative-parity levels which belong to the same family as the high-spin, decoupled, unique-parity states known in other odd mass Pd isotopes. These states correspond to the favored and unfavored anti-aligned levels for core rotations R < or = 6. Calculations in the framework of the particle-rotor model cannot reproduce these level energies

  8. Testing the geomagnetic dipole and reversing dynamo models over Earth's cooling history

    Science.gov (United States)

    Heimpel, Moritz; Evans, Ted

    2014-05-01

    Continental drift reconstructions rely on the assumption that Earth's mean magnetic field has been a geocentric axial dipole over geologic time. However, the coupled dynamics of mantle and core convection may have had profound effects on the magnetic field in the distant past. Previous dynamo models have linked differences between polar and equatorial mantle heat flow to apparently anomalous paleomagnetic fields, and changes in reversal frequency. Here we use the inclination test (Evans, 1976) to interpret observational magnetic field models and polarity-reversing numerical dynamos representing various convective states of the mantle and core. Dynamo models with uniform buoyancy flux represent three convective states of the mantle and core: (1) present era Earth, driven thermo-chemically at the inner core boundary; (2) mantle overturn, with elevated heat flux at the core-mantle boundary, and (3) ancient Earth prior to inner core nucleation, with buoyancy production solely at the CMB. Consistent with Earth's present magnetic field, dynamos driven by buoyancy due to inner core growth are nearly dipolar. In contrast, elevated CMB heat flow yields small to moderate inclination flattening due to a persistent octupole that reverses synchronously with the dipole. For the ancient Earth models the relatively strong octupole component tends to stabilize the dynamo and decrease the reversal frequency. Our results, along with evidence of a young inner core, imply that an entirely liquid core contributed to shallow inclinations in Precambrian time. We also run models with latitudinally variable heat flux boundary conditions to further investigate the relationship between dynamo flow fields, the octupole component, magnetic inclinations and reversal frequency. For models with increased polar CMB heat flux we find that the relative strength of the octupole component increases in proportion to latitudinal heat flux variation. On the other hand, models are very sensitive to enhanced equatorial CMB cooling, which rapidly leads to unstable, multipolar dynamos with high reversal frequencies. This asymmetry in sensitivity to latitudinal variations in CMB heat flux implies that such variations are likely to yield only small inclination anomalies.

  9. Effect of nuclear deformation on the alpha-decay half-life of even-even alpha emitters

    International Nuclear Information System (INIS)

    Alpha-decay half-life of even-even emitters has been calculated in terms of a tunnelling through a quantum mechanical potential barrier. A multipolar expansion of Coulomb potential has been developed taking into account the nuclear quadrupole, hexadecapole, and hexacontatetrapole deformations. We show that using a free-parameter model the calculated half-lives do not vary significantly with higher order multipolarities of the daughter nucleus deformation. (author)

  10. Assessment of Subcortical Source Localization Using Deep Brain Activity Imaging Model with Minimum Norm Operators: A MEG Study

    OpenAIRE

    Attal, Yohan; Schwartz, Denis

    2013-01-01

    Subcortical structures are involved in many healthy and pathological brain processes. It is crucial for many studies to use magnetoencephalography (MEG) to assess the ability to detect subcortical generators. This study aims to assess the source localization accuracy and to compare the characteristics of three inverse operators in the specific case of subcortical generators. MEG has a low sensitivity to subcortical sources mainly because of their distance from sensors and their complex cyto-a...

  11. Model Validation and Model Error Modeling

    OpenAIRE

    Ljung, Lennart

    1999-01-01

    To validate an estimated model and to have a good understanding of its reliability is a central aspect of System Identification. This contribution discusses these aspects in the light of model error models that are explicit descriptions of the model error. A model error model is implicitly present in most model validation methods, so the concept is more of a representation form than a set of new techniques. Traditional model validation is essentially a test of whether the confidence region of...

  12. Models, Fiction, and Fictional Models

    Science.gov (United States)

    Liu, Chuang

    2014-03-01

    The following sections are included: * Introduction * Why Most Models in Science Are Not Fictional * Typically Fictional Models in Science * Modeling the Unobservable * Fictional Models for the Unobservable? * References

  13. A Real-Time Magnetoencephalography Brain-Computer Interface Using Interactive 3D Visualization and the Hadoop Ecosystem.

    Science.gov (United States)

    McClay, Wilbert A; Yadav, Nancy; Ozbek, Yusuf; Haas, Andy; Attias, Hagaii T; Nagarajan, Srikantan S

    2015-01-01

    Ecumenically, the fastest growing segment of Big Data is human biology-related data and the annual data creation is on the order of zetabytes. The implications are global across industries, of which the treatment of brain related illnesses and trauma could see the most significant and immediate effects. The next generation of health care IT and sensory devices are acquiring and storing massive amounts of patient related data. An innovative Brain-Computer Interface (BCI) for interactive 3D visualization is presented utilizing the Hadoop Ecosystem for data analysis and storage. The BCI is an implementation of Bayesian factor analysis algorithms that can distinguish distinct thought actions using magneto encephalographic (MEG) brain signals. We have collected data on five subjects yielding 90% positive performance in MEG mid- and post-movement activity. We describe a driver that substitutes the actions of the BCI as mouse button presses for real-time use in visual simulations. This process has been added into a flight visualization demonstration. By thinking left or right, the user experiences the aircraft turning in the chosen direction. The driver components of the BCI can be compiled into any software and substitute a user's intent for specific keyboard strikes or mouse button presses. The BCI's data analytics OPEN ACCESS Brain. Sci. 2015, 5 420 of a subject's MEG brainwaves and flight visualization performance are stored and analyzed using the Hadoop Ecosystem as a quick retrieval data warehouse. PMID:26437432

  14. Crisis del lóbulo temporal registrada mediante magnetoencefalografía: caso clínico Temporal lobe seizure recorded by magnetoencephalography: case report

    OpenAIRE

    Carlos Amo; Marta Santiuste; Fernando Maestú; Alberto Fernández; Renata Egatz; Mercedes González-Hidalgo; Cristóbal Saldaña; Antonio Sáiz; Tomás Ortiz

    2004-01-01

    La localización del inicio de las crisis es un factor importante para la evaluación prequirúrgica de la epilepsia. En este trabajo se describe la localización del inicio de una crisis registrada mediante magnetoencefalografía (MEG) en un niño de 12 años que presenta crisis parciales complejas farmacorresistentes. La RM muestra una lesión de 20mm de diámetro en el hipocampo izquierdo. EEG de superficie con ondas theta temporales izquierdas. Registro MEG interictal con punta-onda aislada poster...

  15. A Real-Time Magnetoencephalography Brain-Computer Interface Using Interactive 3D Visualization and the Hadoop Ecosystem

    Directory of Open Access Journals (Sweden)

    Wilbert A. McClay

    2015-09-01

    Full Text Available Ecumenically, the fastest growing segment of Big Data is human biology-related data and the annual data creation is on the order of zetabytes. The implications are global across industries, of which the treatment of brain related illnesses and trauma could see the most significant and immediate effects. The next generation of health care IT and sensory devices are acquiring and storing massive amounts of patient related data. An innovative Brain-Computer Interface (BCI for interactive 3D visualization is presented utilizing the Hadoop Ecosystem for data analysis and storage. The BCI is an implementation of Bayesian factor analysis algorithms that can distinguish distinct thought actions using magneto encephalographic (MEG brain signals. We have collected data on five subjects yielding 90% positive performance in MEG mid- and post-movement activity. We describe a driver that substitutes the actions of the BCI as mouse button presses for real-time use in visual simulations. This process has been added into a flight visualization demonstration. By thinking left or right, the user experiences the aircraft turning in the chosen direction. The driver components of the BCI can be compiled into any software and substitute a user’s intent for specific keyboard strikes or mouse button presses. The BCI’s data analytics OPEN ACCESS Brain. Sci. 2015, 5 420 of a subject’s MEG brainwaves and flight visualization performance are stored and analyzed using the Hadoop Ecosystem as a quick retrieval data warehouse.

  16. Model’s comparison

    DEFF Research Database (Denmark)

    Hisham Beshara Halasa, Tariq; Boklund, Anette; Stockmarr, Anders; Enøe, Claes; Christiansen, Lasse Engbo

    Three popular disease spread simulation models were used to simulate the spread of foot-and-mouth disease (FMD) in Denmark. The models’ predictions in term of disease spread, consequence, and the ranking of the applied control strategies were compared. The original Davis Animal Disease Spread (DADS...... version 0.05) was adapted to DTU-DADS, and this model as well as InterSpread Plus (ISP version 2.001.11) and the North American Animal Disease Spread Model (NAADSM version 3.0.81) were all used to simulate hypothetical spread of FMD in Denmark. Data on Danish herds were used including herd type, movements......, and location in the period 1st October 2006 to 30th September 2007. The three models to the highest possible extend set up to simulate the same epidemics in 3 different control scenarios: 1) A basic scenario representing EU and Danish control strategies, 2) pre-emptive depopulation of susceptible...

  17. Las relaciones entre Colombia y Brasil en un contexto de regionalización diversificada en Suramérica y de un mundo multipolar emergente / The Relationship between Colombia and Brazil in the Context of Regional Diversification in South America and an Increasingly Multipolar World

    Scientific Electronic Library Online (English)

    Eduardo, Pastrana Buelvas; Diego, Vera Piñeros.

    2013-12-01

    Full Text Available El artículo interpreta los desafíos que tiene la política exterior colombiana, tanto en el plano regional como en el global, de cara a la proyección de Brasil como potencia regional y jugador global. Para ello, en primer lugar, se lleva a cabo un acercamiento teórico al escenario regional actual y a [...] l horizonte de las relaciones colombo-brasileñas, desde la perspectiva de algunos presupuestos del realismo neoclásico (predominantemente) y del neoliberalismo institucional (subsidiariamente). En segundo lugar, se examinan las fuentes y alcances de la presunta caída de la hegemonía norteamericana y el ascenso gradual de la hegemonía brasileña en Suramérica. En tercer lugar, se analiza la calidad de Colombia como potencia secundaria, luego la diversificación geográfica y temática de su política exterior a partir de agosto de 2010, y sus estrategias de competencia y cooperación con respecto a Brasil en la región. Finalmente, se identifican y se interpretan las perspectivas bilaterales y multilaterales de la profundización de los intercambios y compromisos entre Colombia y Brasil, que tendrían un alto potencial para institucionalizar una alianza estratégica multitemática con repercusiones importantes para impulsar y afianzar el proceso de regionalización en Suramérica. Abstract in english This article interprets the challenges of Colombia's foreign policy, both on a regional and global level, with regard to Brazil's ambitions as a regional power and global player. First, a theoretical analysis of the current regional scenario and the horizon of the Colombian-Brazilian relations is do [...] ne, mainly from various neoclassical realist positions and also from institutional neoliberal viewpoints. Second, sources and impact of the proclaimed decay of the North American hegemony and the gradual rise of a Brasilian hegemony in South America are examined. Third, Colombia's capacity as a secondary power is analized, followed by an analysis of the geographic and thematic diversification of its foreign policy since August 2010, as well as its strategy of competition and cooperation with Brazil in the region. Finally, those bilateral and multilateral perspectives of profundization of the exchanges and committments between Brazil and Colombia are identified and interpreted, which would have a high potential to be institutionalized as a strategic multithematic alliance with an important impact to promote and strengthen the regionalization process in South America.

  18. Mental Models, Conceptual Models, and Modelling.

    Science.gov (United States)

    Greca, Ileana Maria; Moreira, Marco Antonio

    2000-01-01

    Reviews science education research into representations constructed by students in their interactions with the world, its phenomena, and artefacts. Features discussions of mental models, conceptual models, and the activity of modeling. (Contains 30 references.) (Author/WRM)

  19. On macromolecular refinement at subatomic resolution withinteratomic scatterers

    Energy Technology Data Exchange (ETDEWEB)

    Afonine, Pavel V.; Grosse-Kunstleve, Ralf W.; Adams, Paul D.; Lunin, Vladimir Y.; Urzhumtsev, Alexandre

    2007-11-09

    A study of the accurate electron density distribution in molecular crystals at subatomic resolution, better than {approx} 1.0 {angstrom}, requires more detailed models than those based on independent spherical atoms. A tool conventionally used in small-molecule crystallography is the multipolar model. Even at upper resolution limits of 0.8-1.0 {angstrom}, the number of experimental data is insufficient for the full multipolar model refinement. As an alternative, a simpler model composed of conventional independent spherical atoms augmented by additional scatterers to model bonding effects has been proposed. Refinement of these mixed models for several benchmark datasets gave results comparable in quality with results of multipolar refinement and superior of those for conventional models. Applications to several datasets of both small- and macro-molecules are shown. These refinements were performed using the general-purpose macromolecular refinement module phenix.refine of the PHENIX package.

  20. Preferred Ice Crystal Orientation Fabric Measurements within the Greenland Ice Sheet Using Multi-Polarization Radar Data

    Science.gov (United States)

    Velez-Gonzalez, J. A.; JiLu, L.; Leuschen, C.; Gogineni, P.; Van der Veen, C. J.; Tsoflias, G. P.; Drews, R.; Harish, A. R.

    2013-12-01

    Discharge of ice from the Greenland Ice Sheet to the ocean has increased significantly over the last 25 years due to the acceleration of important outlet glaciers. It was reported that the Greenland Ice Sheet contributed about 2.5 m out of about 6 m of sea-level rise during the Eemian interglacial period. The temperatures during Eemian were reported to be about 8o×4o C higher than the mean of the past millennium. Laboratory measurements have shown that glacial ice, characterized by preferred crystal orientation fabric (COF), is three times more deformable than ice with randomly oriented crystalline structures. Layers characterized by preferred ice COF can influence the flow behavior of a glacier or ice sheet. However, COF measurements are typically obtained from ice cores, and thus are very spatially limited and mostly constrained to areas with little ice flow. A more efficient technique to map the extent of ice fabric over larger regions of ice sheets is needed to better understand the effects on large scale ice flow processes. Radar measurements are capable of discriminating between reflections caused by changes in density, electrical permittivity and COF by exploiting the anisotropic and birefringent properties of ice crystals. For this investigation two radar datasets were collected during the survey of the Greenland Eemian Ice Drilling Site (77.45°N 51.06°W) in August 2008, using a ground-based and chirped-pulse Multi-Channel Radar Depth Sounder (MCRDS) developed by the Center for Remote Sensing of Ice Sheets (CReSIS). The radar used two transmit and eight receive antennas at the center frequency of 150 MHz with a bandwidth of 30 MHz. The first data set consisted of polarimatric measurements acquired in a circular pattern (radius: 35 m) with two co-polarized antenna orientations (one transmitter and four receivers oriented with 90° offsets in the directions of the incident H-Field and E-Field, respectively). Analysis of the circular data shows a periodic power variation with four distinct extinction patterns occurring at 90 degree intervals starting at approximately 700 m depth. Furthermore a 20 degree phase change is observed between the E- and H-field data. Both observations suggest that approximately 72% of the 2542m ice column exhibits birefringent anisotropy caused by preferred ice crystal orientation. The second dataset was acquired in a grid pattern consisting of twenty 10-Km 2D lines (NW to SE) spaced at 0.5-Km and three 10-Km lines (NE to SW) spaced at 2.5-Km. Both transmit and eight receive antenna were oriented parallel to the vehicle track, resulting in E-Field co-polarized data. We will determine the dominant COF relative to the ice divide for a 100 square Km region around the NEEM camp using the results from both datasets. The results of this investigation will be compared to the NEEM ice core observations to determine the accuracy of the analysis. In this investigation we will provide a brief overview of the system and experiments and present the results of data analysis.

  1. Assessment of tropical forest stand characteristics with multipolarization SAR data acquired over a mountainous region in Costa Rica

    Science.gov (United States)

    Wu, Shih-Tseng

    1990-01-01

    A digital terrain elevation data set was coregistered with radar data for assessing tropical forest stand characteristics. Both raw and topographically corrected L-band polarimetric radar data acquired over the tropical forests of Costa Rica were analyzed and correlated with field-collected tree parameter data to study the stand characteristics. The results of analyses using 18 out of 81 plots for sites A and B indicated that per-plot bole volume and tree volume are related to SAR data, particularly at site A. The topographically corrected SAR data appear to produce the same findings as those of uncorrected data.

  2. Spin, parity, and multipolarity assignments and g-factor measurements using the TRISTAN superconducting magnet and four detector coincidence apparatus

    International Nuclear Information System (INIS)

    The use of a multidetector ?-ray coincidence system for perturbed and unperturbed ?-ray angular correlations at the on-line mass separator TRISTAN is described. Applications of angular correlation techniques for deducing spin and parity assignments in a variety of even-even nuclides (116Ag, 142Ba, 142Ce, 144Ce), odd-odd nuclides (144La, 138Cs, 132Sb) and odd-mass nuclides (139Xe, 105Rh) are discussed. (Auth.)

  3. Study of H{sup -} production in H{sub 2} microwave multipolar plasmas by optical and electrical diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Soum-Glaude, A.; Bechu, S. [Laboratoire de Physique Subatomique et de Cosmologie, Grenoble (France); Welzel, S.; Engeln, R. [Group Plasma and Materials Processing, Department of Applied Physics, Technische Universiteit Eindhoven, Eindhoven (Netherlands)

    2011-07-01

    A way to achieve heating is the injection in the plasma of highly energetic particles ({approx} MeV) that will transfer their energy during collisions. For this purpose, energetic charged particles are independently created in D{sub 2} plasmas and then neutralized so they can penetrate into the tokamak without being sensitive to the magnetic confinement. Neutral beam injection can deliver up to 16 MW into the ITER plasma. D{sup -} beams are used rather than D{sup +} as the neutralisation of the latter is almost zero instead of 60% for D{sup -}, at the energy of interest. In this framework, our work is devoted to the production of H{sup -} negative ions from H{sub 2} microwave multi-dipolar plasmas. Negative ions are produced inside the plasma volume by dissociative electron attachment to highly vibrationally-excited molecules H{sub 2} (step 3). They can also be produced throughout plasma-surface interactions, where H atoms created in the plasma volume stick on the material (step 1) and recombine with hydrogen present on the surface, resulting in the desorption of a vibrationally-excited H{sub 2} molecule (step 2), which reacts with a cold electron to form a negative ion (step 3). Plasma diagnostics are implemented to better understand the mechanisms involved in H production. Step 3 is studied by means of Langmuir probes for electron density and energy distribution measurements, while laser photo-detachment (Nd-YAG, 1064 nm) gives negative ion densities. H atom densities are followed by Optical Emission Spectroscopy (OES) using actinometry, as well as Laser Induced Fluorescence with one (LIF) or two (TALIF) photons. By generating H atom spatial profiles via Abel transform, we try to differentiate volume mechanisms from surface ones. This document is composed of a short paper followed by a poster

  4. Surface-enhanced Raman scattering on silvered porous alumina templates: role of multipolar surface plasmon resonant modes.

    Science.gov (United States)

    Terekhov, S N; Kachan, S M; Panarin, A Yu; Mojzes, P

    2015-11-25

    Nanostructured silver films with different thicknesses were prepared by vapor deposition onto the surface of the anodic aluminum oxide (AAO) template to be used as surface-enhanced Raman scattering (SERS) active substrates. Both the peak position of the surface plasmon resonance (SPR) band and SERS enhancement of silvered AAO samples displayed non-monotonous dependence on Ag layer thickness. Using 441.6 nm excitation and a water-soluble cationic porphyrin, Cu(ii)-tetrakis(4-N-methylpyridyl) (CuTMPyP4), as a SERS-reporting analyte, two maxima of the SERS enhancement were obtained for Ag layers of 15 and 120 nm thickness. Thickness dependencies have been analyzed taking into account the type of SPR modes identified by means of quasicrystalline approximation (QCA) of statistical theory of multiple scattering of waves and multi-Lorentzian deconvolution. The analysis revealed that SERS enhancement is related to the absolute magnitude of the distance between excitation wavelength and spectral position of collective SPR mode. It was shown that matching of excitation wavelength and the most intensive SPR modes with non-radiative decay, generated mainly by coherent interaction of higher-order plasmon resonant modes (quadrupole and octupole), plays a dominate role in SERS performance. Besides, it has been observed that more intense SERS signal can be obtained when the analyte deposited on the Ag/AAO substrate was excited through the AAO template rather than from the silvered side. Our results demonstrate that appropriate excitation geometry and fine-tuning of the optical properties of the Ag/AAO substrate by adjusting the thickness of the Ag layer with respect to particular excitation wavelength can contribute to more effective SERS enhancement. PMID:26563558

  5. Actant Models

    DEFF Research Database (Denmark)

    Poulsen, Helle

    This paper presents a functional modelling method called Actant Modelling rooted in linguistics and semiotics. Actant modelling can be integrated with Multilevel Flow Modelling (MFM) in order to give an interpretation of actants.......This paper presents a functional modelling method called Actant Modelling rooted in linguistics and semiotics. Actant modelling can be integrated with Multilevel Flow Modelling (MFM) in order to give an interpretation of actants....

  6. Modelling the models

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    By analysing the production of mesons in the forward region of LHC proton-proton collisions, the LHCf collaboration has provided key information needed to calibrate extremely high-energy cosmic ray models.   Average transverse momentum (pT) as a function of rapidity loss ∆y. Black dots represent LHCf data and the red diamonds represent SPS experiment UA7 results. The predictions of hadronic interaction models are shown by open boxes (sibyll 2.1), open circles (qgsjet II-03) and open triangles (epos 1.99). Among these models, epos 1.99 shows the best overall agreement with the LHCf data. LHCf is dedicated to the measurement of neutral particles emitted at extremely small angles in the very forward region of LHC collisions. Two imaging calorimeters – Arm1 and Arm2 – take data 140 m either side of the ATLAS interaction point. “The physics goal of this type of analysis is to provide data for calibrating the hadron interaction models – the well-known &...

  7. Modelling Practice

    DEFF Research Database (Denmark)

    Cameron, Ian; Gani, Rafiqul

    This chapter deals with the practicalities of building, testing, deploying and maintaining models. It gives specific advice for each phase of the modelling cycle. To do this, a modelling framework is introduced which covers: problem and model definition; model conceptualization; model data...... requirements; model construction; model solution; model verification; model validation and finally model deployment and maintenance. Within the adopted methodology, each step is discussedthrough the consideration of key issues and questions relevant to the modelling activity. Practical advice, based on many...... years of experience is providing in directing the reader in their activities.Traps and pitfalls are discussed and strategies also given to improve model development towards “fit-for-purpose” models. The emphasis in this chapter is the adoption and exercise of a modelling methodology that has proven very...

  8. Position models and language modeling

    OpenAIRE

    Zdziobeck, Arnaud; Thollard, Franck

    2008-01-01

    In statistical language modelling the classic model used is $n$-gram. This model is not able however to capture long term dependencies, \\emph{i.e.} dependencies larger than $n$. An alternative to this model is the probabilistic automaton. Unfortunately, it appears that preliminary experiments on the use of this model in language modelling is not yet competitive, partly because it tries to model too long term dependencies. We propose here to improve the use of this model by restricting the dep...

  9. Modelling Practice

    DEFF Research Database (Denmark)

    Cameron, Ian; Gani, Rafiqul

    2011-01-01

    This chapter deals with the practicalities of building, testing, deploying and maintaining models. It gives specific advice for each phase of the modelling cycle. To do this, a modelling framework is introduced which covers: problem and model definition; model conceptualization; model data requirements; model construction; model solution; model verification; model validation and finally model deployment and maintenance. Within the adopted methodology, each step is discussedthrough the consideration of key issues and questions relevant to the modelling activity. Practical advice, based on many years of experience is providing in directing the reader in their activities.Traps and pitfalls are discussed and strategies also given to improve model development towards “fit-for-purpose” models. The emphasis in this chapter is the adoption and exercise of a modelling methodology that has proven very successful in many model building activities. It is vital that good methodologies are adopted for both thoroughness andefficiency purposes. Asking good questions for each modelling stage can aid in getting to effective and efficient solutions in modelling practice. Modelling is very much a ‘goal oriented’ activity, under constraints of system insight, time, cost and human resources. The George Box dictum that “all models are wrong, some are useful” should be coupled with the parsimony principle to ensure optimal outcomes.

  10. Models within models

    International Nuclear Information System (INIS)

    Anyone who worries that physicists are running out of interesting challenges to tackle and important problems to solve should read the two, very different feature articles in this issue. In 'Climate change: complexity in action', Klaus Hasselmann and colleagues write about the challenges of including economic and political dimensions in computer simulations of climate change. It is hard to imagine a physics-based topic that has a greater impact on the world at large. In 'Quarks, diquarks and pentaquarks', Robert Jaffe and Frank Wilczek describe our current understanding of quantum chromodynamics and the strong nuclear force. In this case it is hard to think of many more difficult problems in fundamental physics. Traditional climate modelling is difficult enough because a whole range of effects in the atmosphere and the oceans have to be taken into account. It typically takes weeks for a state-of-the-art supercomputer to simulate 100 years of climate change with a horizontal resolution of 100 km. But climate change is about much more than solving difficult differential equations - there are crucial social, political and economic influences as well. Some researchers, including a significant number of physicists, have started to look at this integrated-assessment approach. The first challenge is to develop climate models that take minutes to run on a laptop. The next challenge is to develop analogous models that work in the social, political and economic arenas - which is not a trivial task - and then integrate all these different models and explore all the possible global-warming scenarios. Physicists also hope to integrate quantum chromodynamics (QCD) into the larger framework of a so-called theory of everything. Like climate modellers, particle theorists working on QCD require enormous computational resources for their calculations, and even then there are limits to what can be achieved (e.g. the mass of the proton has yet to be calculated from first principles). However, QCD can explain the results of an enormous range of experiments, and has recently been given some new particles - 'pentaquarks' - to get its teeth into. Moreover, physicists searching for a theory of everything can take heart from the fact that, unlike researchers working on integrated-assessment models, they already have highly successful theories for the phenomena they are trying to unify. However, the ultimate challenge for the climate community will be to persuade governments and big business that they need to do something to avoid the potentially disastrous consequences of climate change. The UK's chief scientific advisor, David King, made headlines recently when he wrote that, in his view, 'climate change is the most severe problem that we are facing today - more serious even than the threat of terrorism' (Science 303 176-177). It is too soon to say if the message is getting through, but at least climate scientists now have an unlikely ally in the shape of the climate-change disaster movie The Day After Tomorrow. (U.K.)

  11. Polarimetric SAR Data for Urban Land Cover Classification Using Finite Mixture Model

    Science.gov (United States)

    Mahdianpari, Masoud; Akbari, Vahid; Mohammadimanesh, Fariba; Alioghli Fazel, Mohammad

    2013-04-01

    Image classification techniques play an important role in automatic analysis of remote sensing data. This paper demonstrates the potential of polarimetric synthetic aperture radar (PolSAR) for urban land cover mapping using an unsupervised classification approach. Analysis of PolSAR images often shows that non-Gaussian models give better representation of the scattering vector statistics. Hence, processing algorithms based on non-Gaussian statistics should improve performance, compared to complex Gaussian distributions. Several distributions could be used to model SAR image texture with different spatial correlation properties and various degrees of inhomogeneity [1-3]. Statistical properties are widely used for image segmentation and land cover classification of PolSAR data. The pixel-based approaches cluster individual pixels through analysis of their statistical properties. Those methods work well on the relatively coarse spatial resolution images. But classification results based on pixelwise analysis demonstrate the pepper-salt effect of speckle in medium and high resolution applications such as urban area monitoring [4]. Therefore, the expected improvement of the classification results is hindered by the increase of textural differences within a class. In such situation, enhancement could be made through exploring the contextual correlation among pixels by Markov random field (MRF) models [4, 5]. The potential of MRF models to retrieve spatial contextual information is desired to improve the accuracy and reliability of image classification. Unsupervised contextual polarimetric SAR image segmentation is addressed by combining statistical modeling and spatial context within an MRF framework. We employ the stochastic expectation maximization (SEM) algorithm [6] to jointly perform clustering of the data and parameter estimation of the statistical distribution conditioned to each image cluster and the MRF model. This classification method is applied on medium resolution L-band ALOS data from Tehran, Iran. Clustering results are presented and discussed in the full paper, also comparing the classification approach with other commonly used algorithms. References: [1] J.-S. Lee, M. Grunes, and R. Kwok, "Classification of multi-look polarimetric SAR imagery based on the complex Wishart distribution," Int. J Remote Sens., vol. 15, no. 11, pp. 2299-2311, Jul. 1994. [2] C. C. Freitas, A. C. Frery, and A. H. Correia, "The polarimetric G0 distribution for SAR data analysis," Environmetrics, vol. 16, no. 1, pp. 13-31, Feb. 2005. [3] A. P. Doulgeris, S. N. Anfinsen, and T. Eltoft, "Automated non-Gaussian clustering of polarimetric synthetic aperture radar images," IEEE Trans. Geosci. Remote Sens., vol. 49, no. 10, pp. 3665-3676, Oct. 2011. [4]. V. Akbari, A. P. Doulgeris, G. Moser, S. N. Anfinsen, T. Eltoft, and S. Serpico, "A textural-contextual model for unsupervised segmentation of multi-polarization synthetic aperture radar images," IEEE Transactions on Geoscience and Remote Sensing, in press. [5] S. Li, "Markov Random Field Modeling in Image Analysis," 3rd ed. London, U.K., Springer-Verlag, 2009.

  12. Constitutive Models

    DEFF Research Database (Denmark)

    Sales-Cruz, Mauricio; Piccolo, Chiara; Heitzig, Martina; Cameron, Ian; Gani, Rafiqul

    This chapter presents various types of constitutive models and their applications. There are 3 aspects dealt with in this chapter, namely: creation and solution of property models, the application of parameter estimation and finally application examples of constitutive models. A systematic...... procedure is introduced for the analysis and solution of property models. Models that capture and represent the temperature dependent behaviour of physical properties are introduced, as well as equation of state models (EOS) such as the SRK EOS. Modelling of liquid phase activity coefficients are also...... covered, illustrating several models such as the Wilson equation and NRTL equation, along with their solution strategies. A section shows how to use experimental data to regress the property model parameters using a least squares approach. A full model analysis is applied in each example that discusses...

  13. Model theory

    CERN Document Server

    Chang, CC

    2012-01-01

    Model theory deals with a branch of mathematical logic showing connections between a formal language and its interpretations or models. This is the first and most successful textbook in logical model theory. Extensively updated and corrected in 1990 to accommodate developments in model theoretic methods - including classification theory and nonstandard analysis - the third edition added entirely new sections, exercises, and references. Each chapter introduces an individual method and discusses specific applications. Basic methods of constructing models include constants, elementary chains, Sko

  14. Matrix Models

    OpenAIRE

    Sochichiu, Corneliu

    2005-01-01

    Matrix models and their connections to String Theory and noncommutative geometry are discussed. Various types of matrix models are reviewed. Most of interest are IKKT and BFSS models. They are introduced as 0+0 and 1+0 dimensional reduction of Yang--Mills model respectively. They are obtained via the deformations of string/membrane worldsheet/worldvolume. Classical solutions leading to noncommutative gauge models are considered.

  15. Modeling Documents with Event Model

    OpenAIRE

    Longhui Wang; Guoguang Zhao; Donghong Sun

    2015-01-01

    Currently deep learning has made great breakthroughs in visual and speech processing, mainly because it draws lessons from the hierarchical mode that brain deals with images and speech. In the field of NLP, a topic model is one of the important ways for modeling documents. Topic models are built on a generative model that clearly does not match the way humans write. In this paper, we propose Event Model, which is unsupervised and based on the language processing mechanism of neurolinguistics,...

  16. Event Modeling

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2001-01-01

    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse are...... dynamic and we present a modeling approach that can be used to model such dynamics. We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...

  17. Modelling Overview

    DEFF Research Database (Denmark)

    Larsen, Lars Bjørn; Vesterager, Johan

    This report provides an overview of the existing models of global manufacturing, describes the required modelling views and associated methods and identifies tools, which can provide support for this modelling activity.The model adopted for global manufacturing is that of an extended enterprise.......? One or more units from beyond the network may complement the extended enterprise. The common reference model for this extended enterprise will utilise GERAM (Generalised Enterprise Reference Architecture and Methodology) to provide an architectural framework for the modelling carried out within the...

  18. Event Modeling

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2001-01-01

    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse are...... dynamic and we present a modeling approach that can be used to model such dynamics.We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...

  19. Differential Model

    Directory of Open Access Journals (Sweden)

    Ping Du

    2013-01-01

    Full Text Available In order to push table tennis into more cutting-edge area, we need to conduct sound research and simulation for the flying condition of table tennis in the air. This study analyzes the force characteristic of objects moving in the air and establishes differential equation model of three force conditions for the characteristics of table tennis, namely the flight model of table tennis only by gravity, the flight model of table tennis only by gravity and air resistance, as well as the flight model of table tennis only by gravity and air resistance and Magnus force. The research results: For the table tennis flight condition of the first model and the third model it conducts Matlab trajectory situation and achieves good simulation results. The model and simulation methods established in this study provide a theoretical basis for the flight conditions of table tennis in the air and provide a model-based simulation for the movement.

  20. Geochemical modeling

    International Nuclear Information System (INIS)

    Contributions to the workshop 'Geochemical modeling' from 19 to 20 September 1990 at the Karlsruhe Nuclear Research Centre. The report contains the programme and a selection of the lectures held at the workshop 'Geochemical modeling'. (BBR)

  1. Model Building

    OpenAIRE

    Frampton, Paul H.

    1997-01-01

    In this talk I begin with some general discussion of model building in particle theory, emphasizing the need for motivation and testability. Three illustrative examples are then described. The first is the Left-Right model which provides an explanation for the chirality of quarks and leptons. The second is the 331-model which offers a first step to understanding the three generations of quarks and leptons. Third and last is the SU(15) model which can accommodate the light leptoquarks possibly...

  2. Enterprise Modeling

    OpenAIRE

    Fox, Mark S.; Gruninger, Michael

    1998-01-01

    To remain competitive, enterprises must become increasingly agile and integrated across their functions. Enterprise models play a critical role in this integration, enabling better designs for enterprises, analysis of their performance, and management of their operations. This article motivates the need for enterprise models and introduces the concepts of generic and deductive enterprise models. It reviews research to date on enterprise modeling and considers in detail the Toronto virtual ent...

  3. Magnetosphere models

    International Nuclear Information System (INIS)

    In this work the most recent magnetospheric models are reviewed. After a short overview of the particle environment, a synthetic survey of the problem is given. For each feature of magnetospheric modelling (boundary, current sheet, ring-current) the approaches used by different authors are described. In the second part a description is given of the magnetospheric models, divided into four groups. In the last part, the different uses of magnetospheric models are illustrated by means of examples

  4. Interface models

    DEFF Research Database (Denmark)

    Ravn, Anders P.; Staunstrup, Jørgen

    This paper proposes a model for specifying interfaces between concurrently executing modules of a computing system. The model does not prescribe a particular type of communication protocol and is aimed at describing interfaces between both software and hardware modules or a combination of the two....... The model describes both functional and timing properties of an interface...

  5. Zeebrugge Model

    DEFF Research Database (Denmark)

    Sclütter, Flemming; Frigaard, Peter; Liu, Zhou

    This report presents the model test results on wave run-up on the Zeebrugge breakwater under the simulated prototype storms. The model test was performed in January 2000 at the Hydraulics & Coastal Engineering Laboratory, Aalborg University. The detailed description of the model is given in...

  6. Hysteresis modeling

    International Nuclear Information System (INIS)

    The theoretical modeling in complex physical systems may be aimed at an improved precision of empirical description or a deeper physical understanding of the phenomena. The Preisach-type empirical product model of hysteresis as well as a zero temperature Monte Carlo simulation of the magnetization process of an Ising-like dipolar system are discussed as an illustration of modeling examples

  7. Model Selection

    OpenAIRE

    Selén, Yngve

    2004-01-01

    Before using a parametric model one has to be sure that it offers a reasonable description of the system to be modeled. If a bad model structure is employed, the obtained model will also be bad, no matter how good is the parameter estimation method. There exist many possible ways of validating candidate models. This thesis focuses on one of the most common ways, i.e., the use of information criteria. First, some common information criteria are presented, and in the later chapters, various ext...

  8. Actor Model

    CERN Document Server

    Hewitt, Carl

    2010-01-01

    The Actor model is a mathematical theory that treats "Actors" as the universal primitives of concurrent digital computation. The model has been used both as a framework for a theoretical understanding of concurrency, and as the theoretical basis for several practical implementations of concurrent systems. Unlike previous models of computation, the Actor model was inspired by physical laws. It was also influenced by the programming languages Lisp, Simula 67 and Smalltalk-72, as well as ideas for Petri Nets, capability-based systems and packet switching. The advent of massive concurrency through client-cloud computing and many-core computer architectures has galvanized interest in the Actor model.

  9. Chaoticity and dissipation of nuclear collective motion in a classical model

    CERN Document Server

    Baldo, Marcello; Rapisarda, A; Schuck, P

    1996-01-01

    We analyze the behavior of a gas of classical particles moving in a two-dimensional "nuclear" billiard whose multipole-deformed walls undergo periodic shape oscillations. We demonstrate that a single particle Hamiltonian containing coupling terms between the particles' motion and the collective coordinate induces a chaotic dynamics for any multipolarity, independently on the geometry of the billiard. The absence of coupling terms allows us to recover qualitatively the "wall formula" predictions. We also discuss the dissipative behavior of the wall motion and its relation with the order-to-chaos transition in the dynamics of the microscopic degrees of freedom.

  10. Constitutive Models

    DEFF Research Database (Denmark)

    Sales-Cruz, Mauricio; Piccolo, Chiara

    2011-01-01

    This chapter presents various types of constitutive models and their applications. There are 3 aspects dealt with in this chapter, namely: creation and solution of property models, the application of parameter estimation and finally application examples of constitutive models. A systematic procedure is introduced for the analysis and solution of property models. Models that capture and represent the temperature dependent behaviour of physical properties are introduced, as well as equation of state models (EOS) such as the SRK EOS. Modelling of liquid phase activity coefficients are also covered, illustrating several models such as the Wilson equation and NRTL equation, along with their solution strategies. A section shows how to use experimental data to regress the property model parameters using a least squares approach. A full model analysis is applied in each example that discusses the degrees of freedom, dependent and independent variables and solution strategy. Vapour-liquid and solid-liquid equilibrium is covered, and applications to droplet evaporation and kinetic models are given.

  11. ICRF modelling

    International Nuclear Information System (INIS)

    This lecture provides a survey of the methods used to model fast magnetosonic wave coupling, propagation, and absorption in tokamaks. The validity and limitations of three distinct types of modelling codes, which will be contrasted, include discrete models which utilize ray tracing techniques, approximate continuous field models based on a parabolic approximation of the wave equation, and full field models derived using finite difference techniques. Inclusion of mode conversion effects in these models and modification of the minority distribution function will also be discussed. The lecture will conclude with a presentation of time-dependent global transport simulations of ICRF-heated tokamak discharges obtained in conjunction with the ICRF modelling codes. 52 refs., 15 figs

  12. Cadastral Modeling

    DEFF Research Database (Denmark)

    Stubkjær, Erik

    Modeling is a term that refers to a variety of efforts, including data and process modeling. The domain to be modeled may be a department, an organization, or even an industrial sector. E-business presupposes the modeling of an industrial sector, a substantial task. Cadastral modeling compares to...... the modeling of an industrial sector, as it aims at rendering the basic concepts that relate to the domain of real estate and the pertinent human activities. The palpable objects are pieces of land and buildings, documents, data stores and archives, as well as persons in their diverse roles as owners...... related to land. The paper advances the position that cadastral modeling has to include not only the physical objects, agents, and information sets of the domain, but also the objectives or requirements of cadastral systems....

  13. Modelling in Business Model design:

    OpenAIRE

    Simonse, W.L.

    2013-01-01

    It appears that business model design might not always produce a design or model as the expected result. However when designers are involved, a visual model or artefact is produced. To assist strategic managers in thinking about how they can act, the designers challenge is to combine strategy and design notions. However, so far little is known about the modelling methods and recipe approaches that can be used. In this paper the author discusses the development of a methodology for modellin...

  14. Statistical analysis of multipole-model-derived structural parameters and charge-density properties from high-resolution X-ray diffraction experiments.

    Science.gov (United States)

    Kami?ski, Rados?aw; Domaga?a, S?awomir; Jarzembska, Katarzyna N; Hoser, Anna A; Sanjuan-Szklarz, W Fabiola; Gutmann, Matthias J; Makal, Anna; Mali?ska, Maura; B?k, Joanna M; Wo?niak, Krzysztof

    2014-01-01

    A comprehensive analysis of various properties derived from multiple high-resolution X-ray diffraction experiments is reported. A total of 13 charge-density-quality data sets of ?-oxalic acid dihydrate (C2H2O4·2H2O) were subject to Hansen-Coppens-based modelling of electron density. The obtained parameters and properties were then statistically analysed yielding a clear picture of their variability across the different measurements. Additionally, a computational approach (CRYSTAL and PIXEL programs) was utilized to support and examine the experimental findings. The aim of the study was to show the real accuracy and interpretation limits of the charge-density-derived data. An investigation of raw intensities showed that most of the reflections (60-70%) fulfil the normality test and the lowest ratio is observed for weak reflections. It appeared that unit-cell parameters are determined to the order of 10(-3)?Å (for cell edges) and 10(-2)?° (for angles), and compare well with the older studies of the same compound and with the new 100?K neutron diffraction data set. Fit discrepancy factors are determined within a 0.5% range, while the residual density extrema are about ±0.16?(3)?e?Å(-3). The geometry is very well reproducible between different data sets. Regarding the multipole model, the largest errors are present on the valence shell charge-transfer parameters. In addition, symmetry restrictions of multipolar parameters, with respect to local coordinate systems, are well preserved. Standard deviations for electron density are lowest at bond critical points, being especially small for the hydrogen-bonded contacts. The same is true for kinetic and potential energy densities. This is also the case for the electrostatic potential distribution, which is statistically most significant in the hydrogen-bonded regions. Standard deviations for the integrated atomic charges are equal to about 0.1?e. Dipole moments for the water molecule are comparable with the ones presented in various earlier studies. The electrostatic energies should be treated rather qualitatively. However, they are quite well correlated with the PIXEL results. PMID:24419172

  15. Model choice versus model criticism

    OpenAIRE

    Robert, Christian P.; Mengersen, Kerrie,; Chen, Carla

    2009-01-01

    The new perspectives on ABC and Bayesian model criticisms presented in Ratmann et al.(2009) are challenging standard approaches to Bayesian model choice. We discuss here some issues arising from the authors' approach, including prior influence, model assessment and criticism, and the meaning of error in ABC.

  16. Turbulence Model

    DEFF Research Database (Denmark)

    Nielsen, Mogens Peter; Shui, Wan; Johansson, Jens

    In this report a new turbulence model is presented.In contrast to the bulk of modern work, the model is a classical continuum model with a relatively simple constitutive equation. The constitutive equation is, as usual in continuum mechanics, entirely empirical. It has the usual Newton or Stokes...... term with stresses depending linearly on the strain rates. This term takes into account the transfer of linear momentum from one part of the fluid to another. Besides there is another term, which takes into account the transfer of angular momentum. Thus the model implies a new definition of turbulence....... The model is in a virgin state, but a number of numerical tests have been carried out with good results. It is published to encourage other researchers to study the model in order to find its merits and possible limitations....

  17. Modelling Defiguration

    DEFF Research Database (Denmark)

    Bork Petersen, Franziska

    2013-01-01

    focus centres on how the catwalk scenography evokes a ‘defiguration’ of the walking models and to what effect. Vibskov’s mobile catwalk draws attention to the walk, which is a key element of models’ performance but which usually functions in fashion shows merely to present clothes in the most...... advantageous manner. Stepping on the catwalk’s sloping, moving surfaces decelerates the models’ walk and makes it cautious, hesitant and shaky: suddenly the models lack exactly the affirmative, staccato, striving quality of motion, and the condescending expression that they perform on most contemporary...... determines the models’ walk. Furthermore, letting the models set off sound through triggers with attached sound samples gives them an implied agency. This calls into question the designer’s unrestricted authorship....

  18. Turbulence modelling

    International Nuclear Information System (INIS)

    This paper is an introduction course in modelling turbulent thermohydraulics, aimed at computational fluid dynamics users. No specific knowledge other than the Navier Stokes equations is required beforehand. Chapter I (which those who are not beginners can skip) provides basic ideas on turbulence physics and is taken up in a textbook prepared by the teaching team of the ENPC (Benque, Viollet). Chapter II describes turbulent viscosity type modelling and the 2k-? two equations model. It provides details of the channel flow case and the boundary conditions. Chapter III describes the 'standard' (Rij-?) Reynolds tensions transport model and introduces more recent models called 'feasible'. A second paper deals with heat transfer and the effects of gravity, and returns to the Reynolds stress transport model. (author)

  19. Mathematical modelling

    DEFF Research Database (Denmark)

    Blomhøj, Morten

    roots for the construction of important mathematical concepts. In addition competences for setting up, analysing and criticising modelling processes and the possible use of models is a formative aim in this own right for mathematics teaching in general education. The paper presents a theoretical......Developing competences for setting up, analysing and criticising mathematical models are normally seen as relevant only from and above upper secondary level. The general belief among teachers is that modelling activities presuppose conceptual understanding of the mathematics involved. Mathematical...... modelling, however, can be seen as a practice of teaching that place the relation between real life and mathematics into the centre of teaching and learning mathematics, and this is relevant at all levels. Modelling activities may motivate the learning process and help the learner to establish cognitive...

  20. Event Modeling

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2001-01-01

    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse are dynamic and we present a modeling approach that can be used to model such dynamics.We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can be characterized by their occurrence times and the participating books and borrowers. When we characterize events as information objects we focus on concepts like information structures. When viewed as change agents events are phenomena that trigger change. For example, when borrow event occurs books are moved temporarily from bookcases to borrowers. When we characterize events as change agents we focus on concepts like transactions, entity processes, and workflow processes.

  1. Turbulence Model

    DEFF Research Database (Denmark)

    Nielsen, Mogens Peter; Shui, Wan

    2011-01-01

    In this report a new turbulence model is presented.In contrast to the bulk of modern work, the model is a classical continuum model with a relatively simple constitutive equation. The constitutive equation is, as usual in continuum mechanics, entirely empirical. It has the usual Newton or Stokes term with stresses depending linearly on the strain rates. This term takes into account the transfer of linear momentum from one part of the fluid to another. Besides there is another term, which takes into account the transfer of angular momentum. Thus the model implies a new definition of turbulence. The model is in a virgin state, but a number of numerical tests have been carried out with good results. It is published to encourage other researchers to study the model in order to find its merits and possible limitations.

  2. Spherical models

    CERN Document Server

    Wenninger, Magnus J

    2012-01-01

    Well-illustrated, practical approach to creating star-faced spherical forms that can serve as basic structures for geodesic domes. Complete instructions for making models from circular bands of paper with just a ruler and compass. Discusses tessellation, or tiling, and how to make spherical models of the semiregular solids and concludes with a discussion of the relationship of polyhedra to geodesic domes and directions for building models of domes. "". . . very pleasant reading."" - Science. 1979 edition.

  3. Model : making

    OpenAIRE

    Bottle, Neil

    2013-01-01

    The Model : making exhibition was curated by Brian Kennedy in collaboration with Allies & Morrison in September 2013. For the London Design Festival, the Model : making exhibition looked at the increased use of new technologies by both craft-makers and architectural model makers. In both practices traditional ways of making by hand are increasingly being combined with the latest technologies of digital imaging, laser cutting, CNC machining and 3D printing. This exhibition focussed on ...

  4. Zeebrugge Model

    DEFF Research Database (Denmark)

    Liu, Zhou; Frigaard, Peter

    This report presents the model on wave run-up and run-down on the Zeebrugge breakwater under short-crested oblique wave attacks. The model test was performed in March-April 2000 at the Hydraulics & Coastal Engineering Laboratory, Aalborg University.......This report presents the model on wave run-up and run-down on the Zeebrugge breakwater under short-crested oblique wave attacks. The model test was performed in March-April 2000 at the Hydraulics & Coastal Engineering Laboratory, Aalborg University....

  5. PREDICTIVE MODELS

    Energy Technology Data Exchange (ETDEWEB)

    Ray, R.M. (DOE Bartlesville Energy Technology Center, Bartlesville, OK (United States))

    1988-10-01

    PREDICTIVE MODELS is a collection of five models - CFPM, CO2PM, ICPM, PFPM, and SFPM - used in the 1982-1984 National Petroleum Council study of enhanced oil recovery (EOR) potential. Each pertains to a specific EOR process designed to squeeze additional oil from aging or spent oil fields. The processes are: 1) chemical flooding; 2) carbon dioxide miscible flooding; 3) in-situ combustion; 4) polymer flooding; and 5) steamflood. CFPM, the Chemical Flood Predictive Model, models micellar (surfactant)-polymer floods in reservoirs, which have been previously waterflooded to residual oil saturation. Thus, only true tertiary floods are considered. An option allows a rough estimate of oil recovery by caustic or caustic-polymer processes. CO2PM, the Carbon Dioxide miscible flooding Predictive Model, is applicable to both secondary (mobile oil) and tertiary (residual oil) floods, and to either continuous CO2 injection or water-alternating gas processes. ICPM, the In-situ Combustion Predictive Model, computes the recovery and profitability of an in-situ combustion project from generalized performance predictive algorithms. PFPM, the Polymer Flood Predictive Model, is switch-selectable for either polymer or waterflooding, and an option allows the calculation of the incremental oil recovery and economics of polymer relative to waterflooding. SFPM, the Steamflood Predictive Model, is applicable to the steam drive process, but not to cyclic steam injection (steam soak) processes. The IBM PC/AT version includes a plotting capability to produces a graphic picture of the predictive model results.

  6. Stream Modelling

    DEFF Research Database (Denmark)

    Vestergaard, Kristian

    engineers, but as the scale and the complexity of the hydraulic works increased, the mathematical models became so complex that a mathematical solution could not be obtained. This created a demand for new methods and again the experimental investigation became popular, but this time as measurements on small......-scale models. But still the scale and complexity of hydraulic works were increasing, and soon even small-scale models reached a natural limit for some applications. In the mean time the modern computer was developed, and it became possible to solve complex mathematical models by use of computer-based numerical...

  7. Ventilation Model

    International Nuclear Information System (INIS)

    The purpose of the Ventilation Model is to simulate the heat transfer processes in and around waste emplacement drifts during periods of forced ventilation. The model evaluates the effects of emplacement drift ventilation on the thermal conditions in the emplacement drifts and surrounding rock mass, and calculates the heat removal by ventilation as a measure of the viability of ventilation to delay the onset of peak repository temperature and reduce its magnitude. The heat removal by ventilation is temporally and spatially dependent, and is expressed as the fraction of heat carried away by the ventilation air compared to the fraction of heat produced by radionuclide decay. One minus the heat removal is called the wall heat fraction, or the remaining amount of heat that is transferred via conduction to the surrounding rock mass. Downstream models, such as the ''Multiscale Thermohydrologic Model'' (BSC 2001), use the wall heat fractions as outputted from the Ventilation Model to initialize their post-closure analyses. The Ventilation Model report was initially developed to analyze the effects of preclosure continuous ventilation in the Engineered Barrier System (EBS) emplacement drifts, and to provide heat removal data to support EBS design. Revision 00 of the Ventilation Model included documentation of the modeling results from the ANSYS-based heat transfer model. The purposes of Revision 01 of the Ventilation Model are: (1) To validate the conceptual model for preclosure ventilation of emplacement drifts and verify its numerical application in accordance with new procedural requirements as outlined in AP-SIII-10Q, Models (Section 7.0). (2) To satisfy technical issues posed in KTI agreement RDTME 3.14 (Reamer and Williams 2001a). Specifically to demonstrate, with respect to the ANSYS ventilation model, the adequacy of the discretization (Section 6.2.3.1), and the downstream applicability of the model results (i.e. wall heat fractions) to initialize post-closure thermal models (Section 6.6). (3) To satisfy the remainder of KTI agreement TEF 2.07 (Reamer and Williams 2001b). Specifically to provide the results of post-test ANSYS modeling of the Atlas Facility forced convection tests (Section 7.1.2). This portion of the model report also serves as a validation exercise per AP-SIII.10Q, Models, for the ANSYS ventilation model. (4) To further satisfy KTI agreements RDTME 3.01 and 3.14 (Reamer and Williams 2001a) by providing the source documentation referred to in the KTI Letter Report, ''Effect of Forced Ventilation on Thermal-Hydrologic Conditions in the Engineered Barrier System and Near Field Environment'' (Williams 2002). Specifically to provide the results of the MULTIFLUX model which simulates the coupled processes of heat and mass transfer in and around waste emplacement drifts during periods of forced ventilation. This portion of the model report is presented as an Alternative Conceptual Model with a numerical application, and also provides corroborative results used for model validation purposes (Section 6.3 and 6.4)

  8. Modeling Documents with Event Model

    Directory of Open Access Journals (Sweden)

    Longhui Wang

    2015-08-01

    Full Text Available Currently deep learning has made great breakthroughs in visual and speech processing, mainly because it draws lessons from the hierarchical mode that brain deals with images and speech. In the field of NLP, a topic model is one of the important ways for modeling documents. Topic models are built on a generative model that clearly does not match the way humans write. In this paper, we propose Event Model, which is unsupervised and based on the language processing mechanism of neurolinguistics, to model documents. In Event Model, documents are descriptions of concrete or abstract events seen, heard, or sensed by people and words are objects in the events. Event Model has two stages: word learning and dimensionality reduction. Word learning is to learn semantics of words based on deep learning. Dimensionality reduction is the process that representing a document as a low dimensional vector by a linear mode that is completely different from topic models. Event Model achieves state-of-the-art results on document retrieval tasks.

  9. On macromolecular refinement at subatomic resolution with interatomic scatterers

    International Nuclear Information System (INIS)

    Modelling deformation electron density using interatomic scatters is simpler than multipolar methods, produces comparable results at subatomic resolution and can easily be applied to macromolecules. A study of the accurate electron-density distribution in molecular crystals at subatomic resolution (better than ?1.0 Å) requires more detailed models than those based on independent spherical atoms. A tool that is conventionally used in small-molecule crystallography is the multipolar model. Even at upper resolution limits of 0.8–1.0 Å, the number of experimental data is insufficient for full multipolar model refinement. As an alternative, a simpler model composed of conventional independent spherical atoms augmented by additional scatterers to model bonding effects has been proposed. Refinement of these mixed models for several benchmark data sets gave results that were comparable in quality with the results of multipolar refinement and superior to those for conventional models. Applications to several data sets of both small molecules and macromolecules are shown. These refinements were performed using the general-purpose macromolecular refinement module phenix.refine of the PHENIX package

  10. On macromolecular refinement at subatomic resolution with interatomic scatterers

    Energy Technology Data Exchange (ETDEWEB)

    Afonine, Pavel V., E-mail: pafonine@lbl.gov; Grosse-Kunstleve, Ralf W.; Adams, Paul D. [Lawrence Berkeley National Laboratory, One Cyclotron Road, BLDG 64R0121, Berkeley, CA 94720 (United States); Lunin, Vladimir Y. [Institute of Mathematical Problems of Biology, Russian Academy of Sciences, Pushchino 142290 (Russian Federation); Urzhumtsev, Alexandre [IGMBC, 1 Rue L. Fries, 67404 Illkirch and IBMC, 15 Rue R. Descartes, 67084 Strasbourg (France); Faculty of Sciences, Nancy University, 54506 Vandoeuvre-lès-Nancy (France); Lawrence Berkeley National Laboratory, One Cyclotron Road, BLDG 64R0121, Berkeley, CA 94720 (United States)

    2007-11-01

    Modelling deformation electron density using interatomic scatters is simpler than multipolar methods, produces comparable results at subatomic resolution and can easily be applied to macromolecules. A study of the accurate electron-density distribution in molecular crystals at subatomic resolution (better than ?1.0 Å) requires more detailed models than those based on independent spherical atoms. A tool that is conventionally used in small-molecule crystallography is the multipolar model. Even at upper resolution limits of 0.8–1.0 Å, the number of experimental data is insufficient for full multipolar model refinement. As an alternative, a simpler model composed of conventional independent spherical atoms augmented by additional scatterers to model bonding effects has been proposed. Refinement of these mixed models for several benchmark data sets gave results that were comparable in quality with the results of multipolar refinement and superior to those for conventional models. Applications to several data sets of both small molecules and macromolecules are shown. These refinements were performed using the general-purpose macromolecular refinement module phenix.refine of the PHENIX package.

  11. Model Selection for Geostatistical Models

    Energy Technology Data Exchange (ETDEWEB)

    Hoeting, Jennifer A.; Davis, Richard A.; Merton, Andrew A.; Thompson, Sandra E.

    2006-02-01

    We consider the problem of model selection for geospatial data. Spatial correlation is typically ignored in the selection of explanatory variables and this can influence model selection results. For example, the inclusion or exclusion of particular explanatory variables may not be apparent when spatial correlation is ignored. To address this problem, we consider the Akaike Information Criterion (AIC) as applied to a geostatistical model. We offer a heuristic derivation of the AIC in this context and provide simulation results that show that using AIC for a geostatistical model is superior to the often used approach of ignoring spatial correlation in the selection of explanatory variables. These ideas are further demonstrated via a model for lizard abundance. We also employ the principle of minimum description length (MDL) to variable selection for the geostatistical model. The effect of sampling design on the selection of explanatory covariates is also explored.

  12. Computational modelling.

    Science.gov (United States)

    Dayan, P

    1994-04-01

    Computation modelling is playing an increasingly accepted and important role in neuroscience. It is not a unitary enterprise, though, and the distinction between two different sorts of modelling, one interested in description and the other also in function, is illustrated by their application to activity-dependent developmental plasticity and adult conditioning. PMID:8038579

  13. Neurofuzzy Modelling

    DEFF Research Database (Denmark)

    Jantzen, Jan

    1998-01-01

    A neural network can approximate a function, but it is impossible to interpret the result in terms of natural language. The fusion of neural networks and fuzzy logic in neurofuzzy models provide learning as well as readability. Control engineers find this useful, because the models can be...

  14. Modeling Sunspots

    Science.gov (United States)

    Oh, Phil Seok; Oh, Sung Jin

    2013-01-01

    Modeling in science has been studied by education researchers for decades and is now being applied broadly in school. It is among the scientific practices featured in the "Next Generation Science Standards" ("NGSS") (Achieve Inc. 2013). This article describes modeling activities in an extracurricular science club in a high…

  15. Animal models

    DEFF Research Database (Denmark)

    Gøtze, Jens Peter; Krentz, Andrew

    2014-01-01

    In this issue of Cardiovascular Endocrinology, we are proud to present a broad and dedicated spectrum of reviews on animal models in cardiovascular disease. The reviews cover most aspects of animal models in science from basic differences and similarities between small animals and the human pathology, to biomarkers in diagnosis and prognostic evaluation, to drug testing and targeted medicine.

  16. Animal models

    DEFF Research Database (Denmark)

    Gøtze, Jens Peter; Krentz, Andrew

    2014-01-01

    In this issue of Cardiovascular Endocrinology, we are proud to present a broad and dedicated spectrum of reviews on animal models in cardiovascular disease. The reviews cover most aspects of animal models in science from basic differences and similarities between small animals and the human...... pathology, to biomarkers in diagnosis and prognostic evaluation, to drug testing and targeted medicine....

  17. Scribe modeller

    DEFF Research Database (Denmark)

    Løssing, Ulrik

    1986-01-01

    Ulrik Løssing har redigeret, illustreret og oversat: "Scribe Modeller System, Sheffield, november 1985" af forfatterne: Cedric Green, David Cooper og John Wells.......Ulrik Løssing har redigeret, illustreret og oversat: "Scribe Modeller System, Sheffield, november 1985" af forfatterne: Cedric Green, David Cooper og John Wells....

  18. Modelling Constructs

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    There are many different notations and formalisms for modelling business processes and workflows. These notations and formalisms have been introduced with different purposes and objectives. Later, influenced by other notations, comparisons with other tools, or by standardization efforts, these...... notations have been extended in order to increase expressiveness and to be more competitive. This resulted in an increasing number of notations and formalisms for modelling business processes and in an increase of the different modelling constructs provided by modelling notations, which makes it difficult...... to compare modelling notations and to make transformations between them. One of the reasons is that, in each notation, the new concepts are introduced in a different way by extending the already existing constructs. In this chapter, we go the opposite direction: We show that it is possible to add...

  19. Building Models and Building Modelling

    DEFF Research Database (Denmark)

    Jørgensen, Kaj Asbjørn; Skauge, Jørn

    I rapportens indledende kapitel beskrives de primære begreber vedrørende bygningsmodeller og nogle fundamentale forhold vedrørende computerbaseret modulering bliver opstillet. Desuden bliver forskellen mellem tegneprogrammer og bygnings­model­lerings­programmer beskrevet. Vigtige aspekter om comp...... problemstillinger vedrørende modellering af de to "Sorthøjparken"-modeller og de resul­terende modeller bliver præsenteret og evalueret. Den samlede rapport er udgivet på projektets hjemmeside: www.iprod.aau.dk/bygit/Web3B/ under Technical Reports....

  20. OSPREY Model

    Energy Technology Data Exchange (ETDEWEB)

    Veronica J. Rutledge

    2013-01-01

    The absence of industrial scale nuclear fuel reprocessing in the U.S. has precluded the necessary driver for developing the advanced simulation capability now prevalent in so many other countries. Thus, it is essential to model complex series of unit operations to simulate, understand, and predict inherent transient behavior and feedback loops. A capability of accurately simulating the dynamic behavior of advanced fuel cycle separation processes will provide substantial cost savings and many technical benefits. The specific fuel cycle separation process discussed in this report is the off-gas treatment system. The off-gas separation consists of a series of scrubbers and adsorption beds to capture constituents of interest. Dynamic models are being developed to simulate each unit operation involved so each unit operation can be used as a stand-alone model and in series with multiple others. Currently, an adsorption model has been developed within Multi-physics Object Oriented Simulation Environment (MOOSE) developed at the Idaho National Laboratory (INL). Off-gas Separation and REcoverY (OSPREY) models the adsorption of off-gas constituents for dispersed plug flow in a packed bed under non-isothermal and non-isobaric conditions. Inputs to the model include gas, sorbent, and column properties, equilibrium and kinetic data, and inlet conditions. The simulation outputs component concentrations along the column length as a function of time from which breakthrough data is obtained. The breakthrough data can be used to determine bed capacity, which in turn can be used to size columns. It also outputs temperature along the column length as a function of time and pressure drop along the column length. Experimental data and parameters were input into the adsorption model to develop models specific for krypton adsorption. The same can be done for iodine, xenon, and tritium. The model will be validated with experimental breakthrough curves. Customers will be given access to OSPREY to used and evaluate the model.

  1. Stereometric Modelling

    Science.gov (United States)

    Grimaldi, P.

    2012-07-01

    These mandatory guidelines are provided for preparation of papers accepted for publication in the series of Volumes of The The stereometric modelling means modelling achieved with : - the use of a pair of virtual cameras, with parallel axes and positioned at a mutual distance average of 1/10 of the distance camera-object (in practice the realization and use of a stereometric camera in the modeling program); - the shot visualization in two distinct windows - the stereoscopic viewing of the shot while modelling. Since the definition of "3D vision" is inaccurately referred to as the simple perspective of an object, it is required to add the word stereo so that "3D stereo vision " shall stand for "three-dimensional view" and ,therefore, measure the width, height and depth of the surveyed image. Thanks to the development of a stereo metric model , either real or virtual, through the "materialization", either real or virtual, of the optical-stereo metric model made visible with a stereoscope. It is feasible a continuous on line updating of the cultural heritage with the help of photogrammetry and stereometric modelling. The catalogue of the Architectonic Photogrammetry Laboratory of Politecnico di Bari is available on line at: http://rappresentazione.stereofot.it:591/StereoFot/FMPro?-db=StereoFot.fp5&-lay=Scheda&-format=cerca.htm&-view

  2. Programming models

    Energy Technology Data Exchange (ETDEWEB)

    Daniel, David J [Los Alamos National Laboratory; Mc Pherson, Allen [Los Alamos National Laboratory; Thorp, John R [Los Alamos National Laboratory; Barrett, Richard [SNL; Clay, Robert [SNL; De Supinski, Bronis [LLNL; Dube, Evi [LLNL; Heroux, Mike [SNL; Janssen, Curtis [SNL; Langer, Steve [LLNL; Laros, Jim [SNL

    2011-01-14

    A programming model is a set of software technologies that support the expression of algorithms and provide applications with an abstract representation of the capabilities of the underlying hardware architecture. The primary goals are productivity, portability and performance.

  3. Linear Models

    CERN Document Server

    Searle, Shayle R

    2012-01-01

    This 1971 classic on linear models is once again available--as a Wiley Classics Library Edition. It features material that can be understood by any statistician who understands matrix algebra and basic statistical methods.

  4. Micromolecular modeling

    Science.gov (United States)

    Guillet, J. E.

    1984-10-01

    A reaction kinetics based model of the photodegradation process, which measures all important rate constants, and a computerized model capable of predicting the photodegradation rate and failure modes of a 30 year period, were developed. It is shown that the computerized photodegradation model for polyethylene correctly predicts failure of ELVAX 15 and cross linked ELVAX 150 on outdoor exposure. It is indicated that cross linking ethylene vinyl acetate (EVA) does not significantly change its degradation rate. It is shown that the effect of the stabilizer package is approximately equivalent on both polymers. The computerized model indicates that peroxide decomposers and UV absorbers are the most effective stabilizers. It is found that a combination of UV absorbers and a hindered amine light stabilizer (HALS) is the most effective stabilizer system.

  5. Modeling Arcs

    CERN Document Server

    Insepov, Zeke; Veitzer, Seth; Mahalingam, Sudhakar

    2011-01-01

    Although vacuum arcs were first identified over 110 years ago, they are not yet well understood. We have since developed a model of breakdown and gradient limits that tries to explain, in a self-consistent way: arc triggering, plasma initiation, plasma evolution, surface damage and gra- dient limits. We use simple PIC codes for modeling plasmas, molecular dynamics for modeling surface breakdown, and surface damage, and mesoscale surface thermodynamics and finite element electrostatic codes for to evaluate surface properties. Since any given experiment seems to have more variables than data points, we have tried to consider a wide variety of arcing (rf structures, e beam welding, laser ablation, etc.) to help constrain the problem, and concentrate on common mechanisms. While the mechanisms can be comparatively simple, modeling can be challenging.

  6. Model theory

    CERN Document Server

    Hodges, Wilfrid

    1993-01-01

    An up-to-date and integrated introduction to model theory, designed to be used for graduate courses (for students who are familiar with first-order logic), and as a reference for more experienced logicians and mathematicians.

  7. Technicolor model

    International Nuclear Information System (INIS)

    A one family Technicolor model without exact custodial symmetry is examined in the light of the oblique corrections. The effect of isospin breaking term in vector mesons on the oblique parameter S is discussed. (J.P.N.)

  8. Paleoclimate Modeling

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Computer simulations of past climate. Variables provided as model output are described by parameter keyword. In some cases the parameter keywords are a subset of...

  9. Supernova models

    International Nuclear Information System (INIS)

    Recent progress in understanding the observed properties of type I supernovae as a consequence of the thermonuclear detonation of white dwarf stars and the ensuing decay of the Ni-56 produced therein is reviewed. The expected nucleosynthesis and gamma-line spectra for this model of type I explosions and a model for type II explosions are presented. Finally, a qualitatively new approach to the problem of massive star death and type II supernovae based upon a combination of rotation and thermonuclear burning is discussed. While the theoretical results of existing models are predicated upon the assumption of a successful core bounce calculation and the neglect of such two-dimensional effects as rotation and magnetic fields the new model suggests an entirely different scenario in which a considerable portion of the energy carried by an equatorially ejected blob is deposited in the red giant envelope overlying the mantle of the star

  10. Congestion Modelling

    OpenAIRE

    Lindsey, C. Robin; Verhoef, Erik T.

    1999-01-01

    Transportation researchers have long struggled to find satisfactory ways ofdescribing and analysing traffic congestion, as evident from the large numberof often competing approaches and models that have been developed. This paperaims to provide a review of the literature on this topic. The paper startswith the modelling of homogeneous traffic flow and congestion on an isolatedroad under stationary conditions. We set up the supply-demand framework usedto characterize equilibrium and optimal tr...

  11. Lens Model

    DEFF Research Database (Denmark)

    Nash, Ulrik William

    2014-01-01

    Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory of probabilistic functionalism, and concerns the environment and the mind, and adaptation by the latter to the former. This entry is about the lens model, and probabilistic functionalism more broadly. Focus will mo...

  12. PREDICTIVE MODELS

    Energy Technology Data Exchange (ETDEWEB)

    Ray, R.M. (DOE Bartlesville Energy Technology Technology Center, Bartlesville, OK (United States))

    1986-12-01

    PREDICTIVE MODELS is a collection of five models - CFPM, CO2PM, ICPM, PFPM, and SFPM - used in the 1982-1984 National Petroleum Council study of enhanced oil recovery (EOR) potential. Each pertains to a specific EOR process designed to squeeze additional oil from aging or spent oil fields. The processes are: 1) chemical flooding, where soap-like surfactants are injected into the reservoir to wash out the oil; 2) carbon dioxide miscible flooding, where carbon dioxide mixes with the lighter hydrocarbons making the oil easier to displace; 3) in-situ combustion, which uses the heat from burning some of the underground oil to thin the product; 4) polymer flooding, where thick, cohesive material is pumped into a reservoir to push the oil through the underground rock; and 5) steamflood, where pressurized steam is injected underground to thin the oil. CFPM, the Chemical Flood Predictive Model, models micellar (surfactant)-polymer floods in reservoirs, which have been previously waterflooded to residual oil saturation. Thus, only true tertiary floods are considered. An option allows a rough estimate of oil recovery by caustic or caustic-polymer processes. CO2PM, the Carbon Dioxide miscible flooding Predictive Model, is applicable to both secondary (mobile oil) and tertiary (residual oil) floods, and to either continuous CO2 injection or water-alternating gas processes. ICPM, the In-situ Combustion Predictive Model, computes the recovery and profitability of an in-situ combustion project from generalized performance predictive algorithms. PFPM, the Polymer Flood Predictive Model, is switch-selectable for either polymer or waterflooding, and an option allows the calculation of the incremental oil recovery and economics of polymer relative to waterflooding. SFPM, the Steamflood Predictive Model, is applicable to the steam drive process, but not to cyclic steam injection (steam soak) processes.

  13. Accelerated life models modeling and statistical analysis

    CERN Document Server

    Bagdonavicius, Vilijandas

    2001-01-01

    Failure Time DistributionsIntroductionParametric Classes of Failure Time DistributionsAccelerated Life ModelsIntroductionGeneralized Sedyakin's ModelAccelerated Failure Time ModelProportional Hazards ModelGeneralized Proportional Hazards ModelsGeneralized Additive and Additive-Multiplicative Hazards ModelsChanging Shape and Scale ModelsGeneralizationsModels Including Switch-Up and Cycling EffectsHeredity HypothesisSummaryAccelerated Degradation ModelsIntroductionDegradation ModelsModeling the Influence of Explanatory Varia

  14. Radarsat-2 Backscattering for the Modeling of Biophysical Parameters of Regenerating Mangrove Forests

    Directory of Open Access Journals (Sweden)

    Michele F. Cougo

    2015-12-01

    Full Text Available The aim of this study is to understand the relationship between radar backscattering (?°, ?° and ? of a multi-polarized Radarsat-2 C-band image with the structural attributes of regenerating mangrove vegetation located at the mouth of the Amazon River. CBH (circumference at breast height, height and species data were collected to characterize vegetation structure and above-ground biomass (AGB at 17 plots with a total of 3090 measured individuals. Significant relationships between the linear ?° in VH (vertical transmit, horizontal receive cross-polarization produced r2 values of 0.63 for the average height, 0.53 for the DBH, 0.46 for the basal area (BA and 0.52 for the AGB. Using co-polarized HH (horizontal transmit, horizontal receive and VV (vertical transmit, vertical receive, r2 values increased to 0.81, 0.79, 0.67 and 0.79, respectively. Vegetation attribute maps of average canopy height, DBH and AGB were generated for the study area. We conclude that multi-polarized Radarsat-2 images were adequate for characterization of vegetation attributes in areas of mangrove regeneration.

  15. Model composition in model checking

    OpenAIRE

    Felscher, Ingo

    2014-01-01

    Model-checking allows one to formally check properties of systems: these properties are modeled as logic formulas and the systems as structures like transition systems. These transition systems are often composed, i.e., they arise in form of products or sums. The composition technique allows us to deduce the truth of a formula in the composed system from "interface information": the truth of formulas for the component systems and information in which components which of these formulas hold. W...

  16. Complete identification by the particle-rotor model of /sup 153/Gd states up to 1 MeV

    International Nuclear Information System (INIS)

    Measurements performed at the Institut Laue-Langevin in Grenoble regarding gamma rays and conversion electrons following thermal-neutron capture in /sup 152/Gd together with measurements of 2 keV neutron capture in the same nucleus at the High Flux Reactor in Brookhaven have resulted in a 100-level /sup 153/Gd scheme. For some 200 transitions in /sup 153/Gd conversion coefficients have been calculated. This enabled the determination of transition multipolarities and spin and/or parity restrictions for many levels

  17. Mechanistic models

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, S.B.

    1990-09-01

    Several models and theories are reviewed that incorporate the idea of radiation-induced lesions (repairable and/or irreparable) that can be related to molecular lesions in the DNA molecule. Usually the DNA double-strand or chromatin break is suggested as the critical lesion. In the models, the shoulder on the low-LET survival curve is hypothesized as being due to one (or more) of the following three mechanisms: (1) interaction'' of lesions produced by statistically independent particle tracks; (2) nonlinear (i.e., linear-quadratic) increase in the yield of initial lesions, and (3) saturation of repair processes at high dose. Comparisons are made between the various approaches. Several significant advances in model development are discussed; in particular, a description of the matrix formulation of the Markov versions of the RMR and LPL models is given. The more advanced theories have incorporated statistical fluctuations in various aspects of the energy-loss and lesion-formation process. An important direction is the inclusion of physical and chemical processes into the formulations by incorporating relevant track structure theory (Monte Carlo track simulations) and chemical reactions of radiation-induced radicals. At the biological end, identification of repair genes and how they operate as well as a better understanding of how DNA misjoinings lead to lethal chromosome aberrations are needed for appropriate inclusion into the theories. More effort is necessary to model the complex end point of radiation-induced carcinogenesis.

  18. Mechanistic models

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, S.B.

    1990-09-01

    Several models and theories are reviewed that incorporate the idea of radiation-induced lesions (repairable and/or irreparable) that can be related to molecular lesions in the DNA molecule. Usually the DNA double-strand or chromatin break is suggested as the critical lesion. In the models, the shoulder on the low-LET survival curve is hypothesized as being due to one (or more) of the following three mechanisms: (1) ``interaction`` of lesions produced by statistically independent particle tracks; (2) nonlinear (i.e., linear-quadratic) increase in the yield of initial lesions, and (3) saturation of repair processes at high dose. Comparisons are made between the various approaches. Several significant advances in model development are discussed; in particular, a description of the matrix formulation of the Markov versions of the RMR and LPL models is given. The more advanced theories have incorporated statistical fluctuations in various aspects of the energy-loss and lesion-formation process. An important direction is the inclusion of physical and chemical processes into the formulations by incorporating relevant track structure theory (Monte Carlo track simulations) and chemical reactions of radiation-induced radicals. At the biological end, identification of repair genes and how they operate as well as a better understanding of how DNA misjoinings lead to lethal chromosome aberrations are needed for appropriate inclusion into the theories. More effort is necessary to model the complex end point of radiation-induced carcinogenesis.

  19. Lens Model

    DEFF Research Database (Denmark)

    Nash, Ulrik William

    2014-01-01

    Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory of probabil......Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory of...... probabilistic functionalism, and concerns the environment and the mind, and adaptation by the latter to the former. This entry is about the lens model, and probabilistic functionalism more broadly. Focus will mostly be on firms and their employees, but, to fully appreciate the scope, we have to keep in mind the...

  20. Persistent Modelling

    DEFF Research Database (Denmark)

    2012-01-01

    The relationship between representation and the represented is examined here through the notion of persistent modelling. This notion is not novel to the activity of architectural design if it is considered as describing a continued active and iterative engagement with design concerns – an evident...... characteristic of architectural practice. But the persistence in persistent modelling can also be understood to apply in other ways, reflecting and anticipating extended roles for representation. This book identifies three principle areas in which these extensions are becoming apparent within contemporary....... It also provides critical insight into the use of contemporary modelling tools and methods, together with an examination of the implications their use has within the territories of architectural design, realisation and experience....

  1. Droplet model

    International Nuclear Information System (INIS)

    The effectiveness of the liquid drop model is noted, and this model and the leptodermous (A/sup -1/3/ << 1) approaches in general are related to other methods in many-body theory. Then the Hill-Wheeler box is used to show that the leptodermous approach is applicable to quantum systems with even relatively small numbers of particles. The smooth part of the total energy is separated from the shell effects; it is clear that an A/sup 1/3/ term must be included. After a brief introduction to the methods used to obtain the droplet model energy equation, a simplified version is used to display the most important new terms that enter. The theory is applied to calculation of nuclear ground-state masses and single-particle potential well parameters. 17 figures

  2. Subcomponent models

    International Nuclear Information System (INIS)

    According to the instruction given by Professor Lanius and Professor Uhlman, the Conference Chairmen, and by Professor Ranft and Professor Nowak, the Chairmen of the Program Committee, I have organized the Session B04 ''Subcomponent Models'' in the following way: First, I have tried to review recent theoretical works on composite models of quarks and leptons, including twenty-six contributed papers allocated to this session, with the title of ''Composite Models''. Next, I have asked Professor Yamada from University of Tokyo to review recent experimental works related to this subject, including three contributed papers allocated to this session, with the title of ''Experimental Search for Compositeness''. After that, I have invited Professor Mohapatra from University of Maryland and Professor Nielsen from Niels Bohr Institute to give talks on their own recent works contributed to this session, with the titles of ''Fermion Generations and Compositeness'' and ''Field Theories without Fundamental (Gauge) Symmetry'', respectively. (author)

  3. Cheating models

    DEFF Research Database (Denmark)

    Arnoldi, Jakob

    The article discusses the use of algorithmic models for so-called High Frequency Trading (HFT) in finance. HFT is controversial yet widespread in modern financial markets. It is a form of automated trading technology which critics among other things claim can lead to market manipulation. Drawing on...... two cases, this article shows that manipulation more likely happens in the reverse way, meaning that human traders attempt to make algorithms ‘make mistakes’ or ‘mislead’ algos. Thus, it is algorithmic models, not humans, that are manipulated. Such manipulation poses challenges for security exchanges...

  4. Smashnova Model

    OpenAIRE

    Sivaram, C.

    2007-01-01

    An alternate model for gamma ray bursts is suggested. For a white dwarf (WD) and neutron star (NS) very close binary system, the WD (close to Mch) can detonate due to tidal heating, leading to a SN. Material falling on to the NS at relativistic velocities can cause its collapse to a magnetar or quark star or black hole leading to a GRB. As the material smashes on to the NS, it is dubbed the Smashnova model. Here the SN is followed by a GRB. NS impacting a RG (or RSG) (like in Thorne-Zytkow ob...

  5. Modelling language

    CERN Document Server

    Cardey, Sylviane

    2013-01-01

    In response to the need for reliable results from natural language processing, this book presents an original way of decomposing a language(s) in a microscopic manner by means of intra/inter?language norms and divergences, going progressively from languages as systems to the linguistic, mathematical and computational models, which being based on a constructive approach are inherently traceable. Languages are described with their elements aggregating or repelling each other to form viable interrelated micro?systems. The abstract model, which contrary to the current state of the art works in int

  6. Environmental modeling

    CERN Document Server

    Holzbecher, Ekkehard

    2012-01-01

    The book has two aims: to introduce basic concepts of environmental modelling and to facilitate the application of the concepts using modern numerical tools such as MATLAB. It is targeted at all natural scientists dealing with the environment: process and chemical engineers, physicists, chemists, biologists, biochemists, hydrogeologists, geochemists and ecologists. MATLAB was chosen as the major computer tool for modeling, firstly because it is unique in it's capabilities, and secondly because it is available in most academic institutions, in all universities and in the research departments of

  7. Molecular modeling

    Directory of Open Access Journals (Sweden)

    Aarti Sharma

    2009-01-01

    Full Text Available The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and the exponential growth of the knowledge of protein structures have made it possible for organic compounds to be tailored to decrease the harmful side effects and increase the potency. This article provides a detailed description of the techniques employed in molecular modeling. Molecular modeling is a rapidly developing discipline, and has been supported by the dramatic improvements in computer hardware and software in recent years.

  8. Defect modelling

    International Nuclear Information System (INIS)

    Calculations, drawing principally on developments at AERE Harwell, of the relaxation about lattice defects are reviewed with emphasis on the techniques required for such calculations. The principles of defect modelling are outlined and various programs developed for defect simulations are discussed. Particular calculations for metals, ionic crystals and oxides, are considered. (UK)

  9. Zeebrugge Model

    DEFF Research Database (Denmark)

    Jensen, Morten S.; Frigaard, Peter

    In the following, results from model tests with Zeebrugge breakwater are presented. The objective with these tests is partly to investigate the influence on wave run-up due to a changing waterlevel during a storm. Finally, the influence on wave run-up due to an introduced longshore current is...

  10. Modeling Minds

    DEFF Research Database (Denmark)

    Michael, John

    others' minds. Then (2), in order to bring to light some possible justifications, as well as hazards and criticisms of the methodology of looking time tests, I will take a closer look at the concept of folk psychology and will focus on the idea that folk psychology involves using oneself as a model of...

  11. Modeling Muscles

    Science.gov (United States)

    Goodwyn, Lauren; Salm, Sarah

    2007-01-01

    Teaching the anatomy of the muscle system to high school students can be challenging. Students often learn about muscle anatomy by memorizing information from textbooks or by observing plastic, inflexible models. Although these mediums help students learn about muscle placement, the mediums do not facilitate understanding regarding integration of…

  12. Eclipse models

    International Nuclear Information System (INIS)

    This paper addresses the question of, if one overlooks their idiosyncratic difficulties, what could be learned from the various models about the pulsar wind? The wind model requires an MHD wind from the pulsar, namely, one with enough particles that the Poynting flux of the wind can be thermalized. Otherwise, there is no shock and the pulsar wind simply reflects like a flashlight beam. Additionally, a large flux of energetic radiation from the pulsar is required to accompany the wind and drive the wind off the companion. The magnetosphere model probably requires an EM wind, which is Poynting flux dominated. Reflection in this case would arguably minimize the intimate interaction between the two flows that leads to tail formation and thereby permit a weakly magnetized tail. The occulting disk model also would point to an EM wind so that the interaction would be pushed down onto the companion surface (to form the neutral fountain) and so as to also minimize direct interaction of the wind with the orbiting macroscopic particles

  13. Geoinformation modelling.

    Czech Academy of Sciences Publication Activity Database

    Klimešová, Dana; Ocelíková, E.

    Pardubice : Univerzita Pardubice, 2006 - (Taufer, I.; Dušek, F.; Honc, D.), s. 1-5 ISBN 80-7194-860-8. [Process Control 2006. Kouty nad Desnou (CZ), 13.06.2006-16.06.2006] Institutional research plan: CEZ:AV0Z10750506 Keywords : spatial data uncertainty * contextual modelling * context uncertainty * Web services * control GIS Subject RIV: BC - Control Systems Theory

  14. Quasimolecular modelling

    CERN Document Server

    Greenspan, Donald

    1991-01-01

    In this book the author has tried to apply "a little imagination and thinking" to modelling dynamical phenomena from a classical atomic and molecular point of view. Nonlinearity is emphasized, as are phenomena which are elusive from the continuum mechanics point of view. FORTRAN programs are provided in the Appendices.

  15. Why Model?

    Directory of Open Access Journals (Sweden)

    OlafWolkenhauer

    2014-01-01

    Full Text Available Next generation sequencing technologies are bringing about a renaissance of mining approaches. A comprehensive picture of the genetic landscape of an individual patient will be useful, for example, to identify groups of patients that do or do not respond to certain therapies. The high expectations may however not be satisfied if the number of patient groups with similar characteristics is going to be very large. I therefore doubt that mining sequence data will give us an understanding of why and when therapies work. For understanding the mechanisms underlying diseases, an alternative approach is to model small networks in quantitative mechanistic detail, to elucidate the role of gene and proteins in dynamically changing the functioning of cells. Here an obvious critique is that these models consider too few components, compared to what might be relevant for any particular cell function. I show here that mining approaches and dynamical systems theory are two ends of a spectrum of methodologies to choose from. Drawing upon personal experience in numerous interdisciplinary collaborations, I provide guidance on how to model by discussing the question "Why model?"

  16. Numerical models

    Digital Repository Service at National Institute of Oceanography (India)

    Unnikrishnan, A.S.; Manoj, N.T.

    estuarine system of Mandovi and Zuari. The network model could simulate and explain the observed decay of tides at the upstream side (Ganjem in Mandovi and Sanguem in Zuari estuary) caused by the high freshwater discharges during the southwest monsoon season...

  17. Criticality Model

    International Nuclear Information System (INIS)

    The ''Disposal Criticality Analysis Methodology Topical Report'' (YMP 2003) presents the methodology for evaluating potential criticality situations in the monitored geologic repository. As stated in the referenced Topical Report, the detailed methodology for performing the disposal criticality analyses will be documented in model reports. Many of the models developed in support of the Topical Report differ from the definition of models as given in the Office of Civilian Radioactive Waste Management procedure AP-SIII.10Q, ''Models'', in that they are procedural, rather than mathematical. These model reports document the detailed methodology necessary to implement the approach presented in the Disposal Criticality Analysis Methodology Topical Report and provide calculations utilizing the methodology. Thus, the governing procedure for this type of report is AP-3.12Q, ''Design Calculations and Analyses''. The ''Criticality Model'' is of this latter type, providing a process evaluating the criticality potential of in-package and external configurations. The purpose of this analysis is to layout the process for calculating the criticality potential for various in-package and external configurations and to calculate lower-bound tolerance limit (LBTL) values and determine range of applicability (ROA) parameters. The LBTL calculations and the ROA determinations are performed using selected benchmark experiments that are applicable to various waste forms and various in-package and external configurations. The waste forms considered in this calculation are pressurized water reactor (PWR), boiling water reactor (BWR), Fast Flux Test Facility (FFTF), Training Research Isotope General Atomic (TRIGA), Enrico Fermi, Shippingport pressurized water reactor, Shippingport light water breeder reactor (LWBR), N-Reactor, Melt and Dilute, and Fort Saint Vrain Reactor spent nuclear fuel (SNF). The scope of this analysis is to document the criticality computational method. The criticality computational method will be used for evaluating the criticality potential of configurations of fissionable materials (in-package and external to the waste package) within the repository at Yucca Mountain, Nevada for all waste packages/waste forms. The criticality computational method is also applicable to preclosure configurations. The criticality computational method is a component of the methodology presented in ''Disposal Criticality Analysis Methodology Topical Report'' (YMP 2003). How the criticality computational method fits in the overall disposal criticality analysis methodology is illustrated in Figure 1 (YMP 2003, Figure 3). This calculation will not provide direct input to the total system performance assessment for license application. It is to be used as necessary to determine the criticality potential of configuration classes as determined by the configuration probability analysis of the configuration generator model (BSC 2003a)

  18. Criticality Model

    Energy Technology Data Exchange (ETDEWEB)

    A. Alsaed

    2004-09-14

    The ''Disposal Criticality Analysis Methodology Topical Report'' (YMP 2003) presents the methodology for evaluating potential criticality situations in the monitored geologic repository. As stated in the referenced Topical Report, the detailed methodology for performing the disposal criticality analyses will be documented in model reports. Many of the models developed in support of the Topical Report differ from the definition of models as given in the Office of Civilian Radioactive Waste Management procedure AP-SIII.10Q, ''Models'', in that they are procedural, rather than mathematical. These model reports document the detailed methodology necessary to implement the approach presented in the Disposal Criticality Analysis Methodology Topical Report and provide calculations utilizing the methodology. Thus, the governing procedure for this type of report is AP-3.12Q, ''Design Calculations and Analyses''. The ''Criticality Model'' is of this latter type, providing a process evaluating the criticality potential of in-package and external configurations. The purpose of this analysis is to layout the process for calculating the criticality potential for various in-package and external configurations and to calculate lower-bound tolerance limit (LBTL) values and determine range of applicability (ROA) parameters. The LBTL calculations and the ROA determinations are performed using selected benchmark experiments that are applicable to various waste forms and various in-package and external configurations. The waste forms considered in this calculation are pressurized water reactor (PWR), boiling water reactor (BWR), Fast Flux Test Facility (FFTF), Training Research Isotope General Atomic (TRIGA), Enrico Fermi, Shippingport pressurized water reactor, Shippingport light water breeder reactor (LWBR), N-Reactor, Melt and Dilute, and Fort Saint Vrain Reactor spent nuclear fuel (SNF). The scope of this analysis is to document the criticality computational method. The criticality computational method will be used for evaluating the criticality potential of configurations of fissionable materials (in-package and external to the waste package) within the repository at Yucca Mountain, Nevada for all waste packages/waste forms. The criticality computational method is also applicable to preclosure configurations. The criticality computational method is a component of the methodology presented in ''Disposal Criticality Analysis Methodology Topical Report'' (YMP 2003). How the criticality computational method fits in the overall disposal criticality analysis methodology is illustrated in Figure 1 (YMP 2003, Figure 3). This calculation will not provide direct input to the total system performance assessment for license application. It is to be used as necessary to determine the criticality potential of configuration classes as determined by the configuration probability analysis of the configuration generator model (BSC 2003a).

  19. Molecular Modeling

    Science.gov (United States)

    Holmes, Jon L.

    1999-06-01

    Molecular modeling has trickled down from the realm of pharmaceutical and research laboratories into the realm of undergraduate chemistry instruction. It has opened avenues for the visualization of chemical concepts that previously were difficult or impossible to convey. I am sure that many of you have developed exercises using the various molecular modeling tools. It is the desire of this Journal to become an avenue for you to share these exercises among your colleagues. It is to this end that Ron Starkey has agreed to edit such a column and to publish not only the description of such exercises, but also the software documents they use. The WWW is the obvious medium to distribute this combination and so accepted submissions will appear online as a feature of JCE Internet. Typical molecular modeling exercise: finding conformation energies. Molecular Modeling Exercises and Experiments is the latest feature column of JCE Internet, joining Conceptual Questions and Challenge Problems, Hal's Picks, and Mathcad in the Chemistry Curriculum. JCE Internet continues to seek submissions in these areas of interest and submissions of general interest. If you have developed materials and would like to submit them, please see our Guide to Submissions for more information. The Chemical Education Resource Shelf, Equipment Buyers Guide, and WWW Site Review would also like to hear about chemistry textbooks and software, equipment, and WWW sites, respectively. Please consult JCE Internet Features to learn more about these resources at JCE Online. Email Announcements Would you like to be informed by email when the latest issue of the Journal is available online? when a new JCE Software title is shipping? when a new JCE Internet article has been published or is available for Open Review? when your subscription is about to expire? A new feature of JCE Online makes this possible. Visit our Guestbook to learn how. When you submit the form on this page, which includes your email address, you may choose to receive an email notice about a Journal event that interests you. Currently such events include availability of the latest issue of the Journal at JCE Online, expiration of your Journal subscription, shipment of a new JCE Software issue, publication of a new JCE Internet article or its availability for Open Review, and other announcements from the Journal. You may choose any number of these options independently. JCE Online Guestbook. Your Privacy JCE Online promises to you that we will not use the information that you provide in our Guestbook for anything other than our own internal information. We will not provide this information to third parties. We will use the information you provide only in our effort to help make the JCE serve you better. You only need to provide your email address to take advantage of this service; the other information you provide is optional. Molecular Modeling Exercises and Experiments: Mission Statement We are seeking in this JCE Internet feature column to publish molecular modeling exercises and experiments that have been used successfully in undergraduate instruction. The exercises will be published here on JCE Internet. An abstract of published submissions will appear in print in the Journal of Chemical Education. Acceptable exercises could be used in either a chemistry laboratory or a chemistry computer laboratory. The exercise could cover any area of chemistry, but should be limited to undergraduate instructional applications. We envision that most of the exercises/experiments will utilize one of the popular instructional molecular modeling software programs (e.g. HyperChem, Spartan, CAChe, PC Model). Exercises that are specific to a particular modeling program are acceptable, but those usable with any modeling program are preferred. Ideally the exercises/experiments will be of the type where the "correct"answer is not obvious so

  20. Building Models and Building Modelling

    DEFF Research Database (Denmark)

    Jørgensen, Kaj; Skauge, Jørn

    2008-01-01

    I rapportens indledende kapitel beskrives de primære begreber vedrørende bygningsmodeller og nogle fundamentale forhold vedrørende computerbaseret modulering bliver opstillet. Desuden bliver forskellen mellem tegneprogrammer og bygnings­model­lerings­programmer beskrevet. Vigtige aspekter om computerbaseret bygningsmodeller beskrives og de primære potentialer vedrørende modelbaseret design af bygninger bliver fremhævet. De næste to kapitler beskriver fundamentale emner om bygningsmodellering og ...

  1. Lens Model

    DEFF Research Database (Denmark)

    Nash, Ulrik William

    2014-01-01

    Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory of probabilistic functionalism, and concerns the environment and the mind, and adaptation by the latter to the former. This entry is about the lens model, and probabilistic functionalism more broadly. Focus will mostly be on firms and their employees, but, to fully appreciate the scope, we have to keep in mind the fact that probabilistic functionalism extends to all purposive organisms. Probabilistic functionalism is currently experiencing growing interest among strategy scholars, and some very recent papers are highlighted in conclusion.

  2. Molecular Modelling

    Directory of Open Access Journals (Sweden)

    Aarti Sharma

    2009-12-01

    Full Text Available

    The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important
    tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and
    the exponential growth of the knowledge of protein structures have made it possible for organic compounds to tailored to
    decrease harmful side effects and increase the potency. This article provides a detailed description of the techniques
    employed in molecular modeling. Molecular modelling is a rapidly developing discipline, and has been supported from
    the dramatic improvements in computer hardware and software in recent years.

  3. Fibre Models

    Science.gov (United States)

    Herrmann, H. J.; Kun, F.

    2007-12-01

    Fibre models have been introduced as simple models to describe failure. They are based on the probability distribution of broken fibres. The load redistribution after a fibre yields can be global or local and the first case can often be solved analytically. We will present an interpolation between these the local and the global case and apply it to experimental situations like the compression of granular packings. Introducing viscoelastic fibres allows to describe the creep of wood. It is even possible to deal analytically with a gradual degradation of fibres and consider damage as well as healing. In this way Basquin's law of fatigue can be reproduced and new universalities concerning the histograms of bursts and waiting times can be uncovered.

  4. Model Uncertainty

    OpenAIRE

    Clyde, Merlise; George, Edward I.

    2004-01-01

    The evolution of Bayesian approaches for model uncertainty over the past decade has been remarkable. Catalyzed by advances in methods and technology for posterior computation, the scope of these methods has widened substantially. Major thrusts of these developments have included new methods for semiautomatic prior specification and posterior exploration. To illustrate key aspects of this evolution, the highlights of some of these developments are described.

  5. Adsorption Modelling

    OpenAIRE

    Musin, Eduard

    2013-01-01

    In this study, adsorption was explored to remove toxic metals from wastewaters. The main focus of the research work lies on adsorption process, which is described theoretically and studied experimentally. Theoretical part involves studying of the adsorption concepts, adsorbents and adsorption process modelling. Experimental part of the work was aimed to create a condition which will allow examining the adsorption process by using adsorbents to remove toxic metal from aqueous solution. The exp...

  6. Nuclear Models

    International Nuclear Information System (INIS)

    The atomic nucleus is a typical example of a many-body problem. On the one hand, the number of nucleons (protons and neutrons) that constitute the nucleus is too large to allow for exact calculations. On the other hand, the number of constituent particles is too small for the individual nuclear excitation states to be explained by statistical methods. Another problem, particular for the atomic nucleus, is that the nucleon-nucleon (n-n) interaction is not one of the fundamental forces of Nature, and is hard to put in a single closed equation. The nucleon-nucleon interaction also behaves differently between two free nucleons (bare interaction) and between two nucleons in the nuclear medium (dressed interaction).Because of the above reasons, specific nuclear many-body models have been devised of which each one sheds light on some selected aspects of nuclear structure. Only combining the viewpoints of different models, a global insight of the atomic nucleus can be gained. In this chapter, we revise the the Nuclear Shell Model as an example of the microscopic approach, and the Collective Model as an example of the geometric approach. Finally, we study the statistical properties of nuclear spectra, basing on symmetry principles, to find out whether there is quantum chaos in the atomic nucleus. All three major approaches have been rewarded with the Nobel Prize of Physics. In the text, we will stress how each approach introduces its own series of approximations to reduce the prohibitingly large number of degrees of freedom of the full many-body problem to a smaller manageable number of effective degrees of freedom.

  7. Modeling Overstock

    OpenAIRE

    Fernandes, Rui; Gouveia, Borges; Pinho, Carlos

    2010-01-01

    Two main problems have been emerging in supply chain management: the increasing pressure to reduce working capital and the growing variety of products. Most of the popular indicators have been developed based on a controlled environment. A new indicator is now proposed, based on the uncertainty of the demand, the flexibility of the supply chains, the evolution of the products lifecycle and the fulfillment of a required service level. The model to support the indicator will be developed wit...

  8. Modelling tsunamis

    International Nuclear Information System (INIS)

    We doubt the relevance of soliton theory to the modelling of tsunamis, and present a case in support of an alternative view. Although the shallow-water equations do provide, we believe, an appropriate basis for this phenomenon, an asymptotic analysis of the solution for realistic variable depths, and for suitable background flows, is essential for a complete understanding of this phenomenon. In particular we explain how a number of tsunami waves can arrive at a shoreline. (letter to the editor)

  9. Leadership model

    OpenAIRE

    Almeida, Leandro S.; José Fernando A. Cruz; Ferreira, Helena Isabel dos Santos Ribeiro; Pinto, Alberto

    2011-01-01

    The Theory of Planned Behavior studies the decision-making mechanisms of individuals. We propose the Nash Equilibria as one, of many, possible mechanisms of transforming human intentions in behavior. This process corresponds to the best strategic individual decision taking in account the collective response. We built a game theoretical model to understand the role of leaders in decision-making of individuals or groups. We study the characteristics of the leaders that can have a...

  10. A study into the neural processing of natural music in the brains of musicians and non-musicians by means of magnetoencephalography

    OpenAIRE

    Saghafifar, Houra

    2015-01-01

    Studying music processing in the brain is a complex task, which involves multidisciplinary skills to achieve the most constructive results. The current experiment investigated MEG brain signals of musicians, music amateurs and non-musicians while they were listening to three different complete music pieces. Brain signals were also recorded while the subjects were resting with their eyes closed and eyes open. The present study aimed to investigate possible differences between neural respons...

  11. Inter-trial effect in luminance processing revealed by magnetoencephalography / Efecto inter-ensayo en el procesamiento de iluminación revelado por magnetoencefalografía

    Scientific Electronic Library Online (English)

    Aki, Kondo; Katsumi, Watanabe.

    2013-12-15

    Full Text Available En este estudio, se examinó si el procesamiento de iluminación en el sistema visual humano exhibie algún efecto de historia (es decir, modulación inter-ensayo) en experimentos psicofísicos y de magnetoencefalografía (MEG). Un disco se presentó contra un fondo negro en varios niveles de iluminación e [...] n un orden aleatorio. Durante el registro de MEG, los participantes fueron instruidos para clasificar el brillo del disco (estimación de magnitud) y reportarlo durante el intervalo inter-ensayo. Los resultados de MEG mostraron que la activación neuromagnetica alrededor 200-220 ms después de la aparición de estímulo en las regiones occipito-temporal izquierda en un ensayo dade fue más débil cuando la iluminación de disco en el ensayo inmediatamente antes fue mayor. También se observó un efecto inverso inter-ensayo en el experimento psicofísico. Estos hallazgos sugieren que la actividad neuromagnética refleja la modulación inter-ensayo de procesamiento de iluminación que se correlaciona con la percepción subjetiva de brillo. Abstract in english In this study, we examined whether luminance processing in the human visual system would exhibit any history effect (i.e., inter-trial modulation) in psychophysical and magnetoencephalographic experiments. A disk was presented against a black background at various luminance levels in a randomized or [...] der. During the MEG recording, participants were instructed to rate the brightness of the disk (magnitude estimation) and to report it aloud during inter-stimulus interval. The MEG results showed that the neuromagnetic activation around 200-220 ms after the stimulus onset in the left occipito-temporal regions at a given trial was weaker when the disk luminance in the immediately prior trial was higher. An inverse inter-trial effect was also observed in the psychophysical experiment. These findings suggest that the neuromagnetic activity reflects the inter-trial modulation of luminance processing that correlates with the subjective perception of brightness.

  12. Time-Constrained Functional Connectivity Analysis of Cortical Networks Underlying Phonological Decoding in Typically Developing School-Aged Children: A Magnetoencephalography Study

    Science.gov (United States)

    Simos, Panagiotis G.; Rezaie, Roozbeh; Fletcher, Jack M.; Papanicolaou, Andrew C.

    2013-01-01

    The study investigated functional associations between left hemisphere occipitotemporal, temporoparietal, and inferior frontal regions during oral pseudoword reading in 58 school-aged children with typical reading skills (aged 10.4 [plus or minus] 1.6, range 7.5-12.5 years). Event-related neuromagnetic data were used to compute source-current…

  13. Modeling biomembranes.

    Energy Technology Data Exchange (ETDEWEB)

    Plimpton, Steven James; Heffernan, Julieanne; Sasaki, Darryl Yoshio; Frischknecht, Amalie Lucile; Stevens, Mark Jackson; Frink, Laura J. Douglas

    2005-11-01

    Understanding the properties and behavior of biomembranes is fundamental to many biological processes and technologies. Microdomains in biomembranes or ''lipid rafts'' are now known to be an integral part of cell signaling, vesicle formation, fusion processes, protein trafficking, and viral and toxin infection processes. Understanding how microdomains form, how they depend on membrane constituents, and how they act not only has biological implications, but also will impact Sandia's effort in development of membranes that structurally adapt to their environment in a controlled manner. To provide such understanding, we created physically-based models of biomembranes. Molecular dynamics (MD) simulations and classical density functional theory (DFT) calculations using these models were applied to phenomena such as microdomain formation, membrane fusion, pattern formation, and protein insertion. Because lipid dynamics and self-organization in membranes occur on length and time scales beyond atomistic MD, we used coarse-grained models of double tail lipid molecules that spontaneously self-assemble into bilayers. DFT provided equilibrium information on membrane structure. Experimental work was performed to further help elucidate the fundamental membrane organization principles.

  14. Ozone modeling

    International Nuclear Information System (INIS)

    Exhaust gases from power plants that burn fossil fuels contain concentrations of sulfur dioxide (SO2), nitric oxide (NO), particulate matter, hydrocarbon compounds and trace metals. Estimated emissions from the operation of a hypothetical 500 MW coal-fired power plant are given. Ozone is considered a secondary pollutant, since it is not emitted directly into the atmosphere but is formed from other air pollutants, specifically, nitrogen oxides (NO), and non-methane organic compounds (NMOQ) in the presence of sunlight. (NMOC are sometimes referred to as hydrocarbons, HC, or volatile organic compounds, VOC, and they may or may not include methane). Additionally, ozone formation Alternative is a function of the ratio of NMOC concentrations to NOx concentrations. A typical ozone isopleth is shown, generated with the Empirical Kinetic Modeling Approach (EKMA) option of the Environmental Protection Agency's (EPA) Ozone Isopleth Plotting Mechanism (OZIPM-4) model. Ozone isopleth diagrams, originally generated with smog chamber data, are more commonly generated with photochemical reaction mechanisms and tested against smog chamber data. The shape of the isopleth curves is a function of the region (i.e. background conditions) where ozone concentrations are simulated. The location of an ozone concentration on the isopleth diagram is defined by the ratio of NMOC and NOx coordinates of the point, known as the NMOC/NOx ratio. Results obtained by the described model are presented

  15. Students' Models of Curve Fitting: A Models and Modeling Perspective

    Science.gov (United States)

    Gupta, Shweta

    2010-01-01

    The Models and Modeling Perspectives (MMP) has evolved out of research that began 26 years ago. MMP researchers use Model Eliciting Activities (MEAs) to elicit students' mental models. In this study MMP was used as the conceptual framework to investigate the nature of students' models of curve fitting in a problem-solving environment consisting of…

  16. Modelling Sonoluminescence

    OpenAIRE

    Chodos, Alan; Groff, Sarah

    1998-01-01

    In single-bubble sonoluminescence, a bubble trapped by a sound wave in a flask of liquid is forced to expand and contract; exactly once per cycle, the bubble emits a very sharp ($< 50 ps$) pulse of visible light. This is a robust phenomenon observable to the naked eye, yet the mechanism whereby the light is produced is not well understood. One model that has been proposed is that the light is "vacuum radiation" generated by the coupling of the electromagnetic fields to the surface of the bubb...

  17. Document Models

    CERN Document Server

    Van Herwijnen, Eric

    1997-01-01

    Exchanging electronic texts in different formats has been a problem for many years. For example, it is difficult to convert a TeX document into an MS Word document. Proprietary solutions exist for specific purposes, but their application is restricted to a limited community of users. A truly universal for document archival consists of the use of a number of standards for document models. This article describes the standards that have been recently adopted in that area : SGML, CALS, HTML, XML, HyTime, DSSSL, CSS, MHEG and PREMO. Together, they attempt to solve the problem of interchanging and reusing composite documents.

  18. Approximate Waveforms for Extreme-Mass-Ratio Inspirals: The Chimera Scheme

    Science.gov (United States)

    Sopuerta, Carlos F.; Yunes, Nicolás

    2012-06-01

    We describe a new kludge scheme to model the dynamics of generic extreme-mass-ratio inspirals (EMRIs; stellar compact objects spiraling into a spinning supermassive black hole) and their gravitational-wave emission. The Chimera scheme is a hybrid method that combines tools from different approximation techniques in General Relativity: (i) A multipolar, post-Minkowskian expansion for the far-zone metric perturbation (the gravitational waveforms) and for the local prescription of the self-force; (ii) a post-Newtonian expansion for the computation of the multipole moments in terms of the trajectories; and (iii) a BH perturbation theory expansion when treating the trajectories as a sequence of self-adjusting Kerr geodesies. The EMRI trajectory is made out of Kerr geodesic fragments joined via the method of osculating elements as dictated by the multipolar post-Minkowskian radiation-reaction prescription. We implemented the proper coordinate mapping between Boyer-Lindquist coordinates, associated with the Kerr geodesies, and harmonic coordinates, associated with the multipolar post-Minkowskian decomposition. The Chimera scheme is thus a combination of approximations that can be used to model generic inspirals of systems with extreme to intermediate mass ratios, and hence, it can provide valuable information for future space-based gravitational-wave observatories, like LISA, and even for advanced ground detectors. The local character in time of our multipolar post-Minkowskian self-force makes this scheme amenable to study the possible appearance of transient resonances in generic inspirals.

  19. Better Language Models with Model Merging

    OpenAIRE

    Brants, Thorsten

    1996-01-01

    This paper investigates model merging, a technique for deriving Markov models from text or speech corpora. Models are derived by starting with a large and specific model and by successively combining states to build smaller and more general models. We present methods to reduce the time complexity of the algorithm and report on experiments on deriving language models for a speech recognition task. The experiments show the advantage of model merging over the standard bigram approach. The merged...

  20. Many-body theory of dilute gas condensates - derivation of a field-modified Gross-Pitaevskii equation from multipolar QED

    CERN Document Server

    Boussiakou, L G; Babiker, M

    2000-01-01

    The Hamiltonian of a moving atom in electromagnetic fields includes velocity- dependent terms. We show that the leading velocity dependence emerges systematically in the non-relativistic limit from a scheme firmly based on the relativistic invariance of the energy-momentum stress tensor of the coupled matter-fields system. We then extend the Hamiltonian to the many-body situation suitable for describing a Bose-Einstein condensate (BEC). From first principles, we use the equation of motion for the condensate wavefunction to obtain an extended version of the Gross-Pitaevskii (GP) equation and an equation for the internal states of the atoms. It is shown that laser fields modify the GP equation by inclusion of convective terms involving a Rontgen interaction plus a term coupling the centre of mass momentum to the Poynting vector. We also obtain the modified Maxwell equations for the electromagnetic fields coupled to the BEC involving the average velocity of the atoms.

  1. The Novelty of Europe as seen from the Periphery: Indian Perception of the 'New Europe' in a Multi-polar world

    OpenAIRE

    Mitra, Subrata K.

    2005-01-01

    Europa ist, so verstanden, dass eine Stimme den Anspruch erhebt, für alle fünfundzwanzig zu sprechen, selbst für den vermeintlichen Europäer etwas Neues. Verständlicherweise herrscht bei den Außenstehenden mit dem Blick nach Europa hinein eher Unverständnis und Konfusion. Folglich bleibt das Verständnis des neuen Europas bei Nicht-Europäern vage, widersprüchlich und fragwürdig, begleitet von einem besorgten Unterton. In diesem Artikel werden, schwerpunktmäßig aus der Sicht Indiens, die Ursprü...

  2. Multipolarity of statistical #betta#-rays from f-p shell nuclei produced in deep-inelastic heavy-ion reactions

    International Nuclear Information System (INIS)

    Measurements of the circular polarization and the angular correlation of #betta#-rays from highly excited polarized nuclei, produced in 16O+58Ni deep-inelastic reactions, indicate a strong quadrupole component in the spectra of statistical #betta#-decay at Esub(#betta#)>2 MeV. Differences in the anisotropies observed for the 16O+58Ni and the 16O+48Ti reactions are attributed to the influence of nuclear structure. (orig.)

  3. Discrete choice models

    OpenAIRE

    Boštjan Kerbler

    2006-01-01

    The paper systematically describes special regression methods – discrete choice models – known as probability models. The meaning of models and their methodological characteristics are described, as well as different types of models, especially binary-choice models and censored regression models. We considered three most commonly used approaches to estimating such models – logit, probit and tobit model.

  4. Application of radar polarimetry to forestry

    Science.gov (United States)

    Durden, S. L.; Zebker, H. A.; Vanzyl, J. J.

    1988-01-01

    In order to understand L-band multipolarization radar measurements of forested areas, a model for the forest polarization signature was developed. The model is based on backscatter from dielectric cylinders which represent branches and trunks. In the model the Stokes matrices corresponding to several different scattering mechanisms is calculated, combining the results to get the total Stokes matrix. Comparison of model predictions with radar measurements shows that the model can accurately predict the forest polarization signature.

  5. Pre-Modeling Ensures Accurate Solid Models

    Science.gov (United States)

    Gow, George

    2010-01-01

    Successful solid modeling requires a well-organized design tree. The design tree is a list of all the object's features and the sequential order in which they are modeled. The solid-modeling process is faster and less prone to modeling errors when the design tree is a simple and geometrically logical definition of the modeled object. Few high…

  6. Modelling Sonoluminescence

    CERN Document Server

    Chodos, A; Chodos, Alan; Groff, Sarah

    1999-01-01

    In single-bubble sonoluminescence, a bubble trapped by a sound wave in a flask of liquid is forced to expand and contract; exactly once per cycle, the bubble emits a very sharp ($< 50 ps$) pulse of visible light. This is a robust phenomenon observable to the naked eye, yet the mechanism whereby the light is produced is not well understood. One model that has been proposed is that the light is "vacuum radiation" generated by the coupling of the electromagnetic fields to the surface of the bubble. In this paper, we simulate vacuum radiation by solving Maxwell's equations with an additional term that couples the field to the bubble's motion. We show that, in the static case originally considered by Casimir, we reproduce Casimir's result. In a simple purely time-dependent example, we find that an instability occurs and the pulse of radiation grows exponentially. In the more realistic case of spherically-symmetric bubble motion, we again find exponential growth in the context of a small-radius approximation.

  7. Model Awal Dan Model Klasik Struktur Informasi

    OpenAIRE

    Widayati, Dwi

    2010-01-01

    This paper describes early models of information structure and classical models of information structure. Early models of information structure consist of (1) subject- predicate structure, (2) the early psychological model, (3) the communicative model, and (4) linguistics, psychology, and information structure. Classical models is begun from the Prague school, Halliday and the American structuralists, Chafe on givenness, and Chomsky on focus and presupposition. The most characteristic feat...

  8. Model Selection in Linear Mixed Models

    OpenAIRE

    Müller, Samuel; Scealy, J. L.; Welsh, A. H.

    2013-01-01

    Linear mixed effects models are highly flexible in handling a broad range of data types and are therefore widely used in applications. A key part in the analysis of data is model selection, which often aims to choose a parsimonious model with other desirable properties from a possibly very large set of candidate statistical models. Over the last 5-10 years the literature on model selection in linear mixed models has grown extremely rapidly. The problem is much more complicat...

  9. Towards a Multi Business Model Innovation Model

    DEFF Research Database (Denmark)

    Lindgren, Peter; Jørgensen, Rasmus

    2012-01-01

    This paper studies the evolution of business model (BM) innovations related to a multi business model framework. The paper tries to answer the research questions: • What are the requirements for a multi business model innovation model (BMIM)? • How should a multi business model innovation model...... look like? Different generations of BMIMs are initially studied in the context of laying the baseline for how next generation multi BM Innovation model (BMIM) should look like. All generations of models are analyzed with the purpose of comparing the characteristics and challenges of previous...

  10. Fully Automated Whole-Head Segmentation with Improved Smoothness and Continuity, with Theory Reviewed

    OpenAIRE

    Huang, Yu; Lucas C. Parra

    2015-01-01

    Individualized current-flow models are needed for precise targeting of brain structures using transcranial electrical or magnetic stimulation (TES/TMS). The same is true for current-source reconstruction in electroencephalography and magnetoencephalography (EEG/MEG). The first step in generating such models is to obtain an accurate segmentation of individual head anatomy, including not only brain but also cerebrospinal fluid (CSF), skull and soft tissues, with a field of view (FOV) that cover...

  11. The IMACLIM model; Le modele IMACLIM

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This document provides annexes to the IMACLIM model which propose an actualized description of IMACLIM, model allowing the design of an evaluation tool of the greenhouse gases reduction policies. The model is described in a version coupled with the POLES, technical and economical model of the energy industry. Notations, equations, sources, processing and specifications are proposed and detailed. (A.L.B.)

  12. From Product Models to Product State Models

    DEFF Research Database (Denmark)

    Larsen, Michael Holm

    1999-01-01

    A well-known technology designed to handle product data is Product Models. Product Models are in their current form not able to handle all types of product state information. Hence, the concept of a Product State Model (PSM) is proposed. The PSM and in particular how to model a PSM is the Research...

  13. I and C Modeling in SPAR Models

    International Nuclear Information System (INIS)

    The Standardized Plant Analysis Risk (SPAR) models for the U.S. commercial nuclear power plants currently have very limited instrumentation and control (I and C) modeling (1). Most of the I and C components in the operating plant SPAR models are related to the reactor protection system. This was identified as a finding during the industry peer review of SPAR models. While the Emergency Safeguard Features (ESF) actuation and control system was incorporated into the Peach Bottom Unit 2 SPAR model in a recent effort (2), various approaches to expend resources for detailed I and C modeling in other SPAR models are investigated.

  14. Concept Modeling vs. Data modeling in Practice

    DEFF Research Database (Denmark)

    Madsen, Bodil Nistrup; Erdman Thomsen, Hanne

    2015-01-01

    This chapter shows the usefulness of terminological concept modeling as a first step in data modeling. First, we introduce terminological concept modeling with terminological ontologies, i.e. concept systems enriched with characteristics modeled as feature specifications. This enables a formal account of the inheritance of characteristics and allows us to introduce a number of principles and constraints which render concept modeling more coherent than earlier approaches. Second, we explain how terminological ontologies can be used as the basis for developing conceptual and logical data models. We also show how to map from the various elements in the terminological ontology to elements in the data models, and explain the differences between the models. Finally the usefulness of terminological ontologies as a prerequisite for IT development and data modeling is illustrated with examples from the Danish public sector (a user interface for drug prescription and a data model for food control).

  15. A model driven approach to model transformations.

    OpenAIRE

    Appukuttan, Biju K.; Clark, Tony; Reddy, Sreedhar; Tratt, Laurence; Venkatesh, R.

    2003-01-01

    The OMG's Model Driven Architecture (MDA) initiative has been the focus of much attention in both academia and industry, due to its promise of more rapid and consistent software development through the increased use of models. In order for MDA to reach its full potential, the ability to manipulate and transform models { most obviously from the Platform Independent Model (PIM) to the Platform Specic Models (PSM) { is vital. Recognizing this need, the OMG issued a Request For Proposals (RFP)...

  16. From 1-matrix model to Kontsevich model

    OpenAIRE

    Ambjorn, Jan; Kristjansen, Charlotte F.

    1993-01-01

    Loop equations of matrix models express the invariance of the models under field redefinitions. We use loop equations to prove that it is possible to define continuum times for the generic hermitian {1-matrix} model such that all correlation functions in the double scaling limit agree with the corresponding correlation functions of the Kontsevich model expressed in terms of kdV times. In addition the double scaling limit of the partition function of the hermitian matrix model agree with the $...

  17. Rotating universe models

    International Nuclear Information System (INIS)

    A review is made of some properties of the rotating Universe models. Godel's model is identified as a generalized filted model. Some properties of new solutions of the Einstein's equations, which are rotating non-stationary Universe models, are presented and analyzed. These models have the Godel's model as a particular case. Non-stationary cosmological models are found which are a generalization of the Godel's metrics in an analogous way in which Friedmann is to the Einstein's model. (L.C.)

  18. Concept Modeling vs. Data modeling in Practice

    DEFF Research Database (Denmark)

    Madsen, Bodil Nistrup; Erdman Thomsen, Hanne

    This chapter shows the usefulness of terminological concept modeling as a first step in data modeling. First, we introduce terminological concept modeling with terminological ontologies, i.e. concept systems enriched with characteristics modeled as feature specifications. This enables a formal...... account of the inheritance of characteristics and allows us to introduce a number of principles and constraints which render concept modeling more coherent than earlier approaches. Second, we explain how terminological ontologies can be used as the basis for developing conceptual and logical data models....... We also show how to map from the various elements in the terminological ontology to elements in the data models, and explain the differences between the models. Finally the usefulness of terminological ontologies as a prerequisite for IT development and data modeling is illustrated with examples from...

  19. Comparisons of debris environment model breakup models

    Science.gov (United States)

    Jonas, F.; Yates, K.; Evans, R.

    1993-01-01

    This paper presents a comparison of current spacecraft breakup models used in orbital (space) debris computational environment models. The breakup models to be compared come from the NASA EVOLVE (Evolutionary) model long term debris model, the IMPACT code developed by Aerospace Corp., and the Fragmentation Algorithms for Satellite Targets (FAST) developed by Kaman Sciences. The comparison will show the methodologies and results obtained for each model such as mass versus fragment number distributions. Implications for debris cloud formation will be discussed in terms of the environments produced. No attempt is made to recommend any one model over the other as each were designed and employed for specific purposes in the environment models they are part of or contribute to. The comparisons are intended to provide researchers both quantitative and qualitative information on the models for use in their own research activities.

  20. Common Modeling Language for Model Checkers

    Directory of Open Access Journals (Sweden)

    Pathiah A.  Samat

    2012-01-01

    Full Text Available Problem statement: There are many different model checkers that have been developed. Each of the model checkers is based on different input languages and they are suitable for model checking different types of systems. Thus it is important for us to choose the right model checker or modeling and verifying a given system. However, moving from one model checker to another is not an easy task since we have to deal with different input languages. Approach: In order to solve the problem we propose a common modeling language that is based on UML state chart. Some translation rules for translating the model described in the common modeling language into the input languages of model checkers are also presented. Results: The result of the case study shows that our approach has been successfully applied in modeling the control system through the process of transformation and translation. Conclusion: Common modeling language can be used as a front end to help users to properly model a system before it is translated into input language of model checkers.

  1. Model confidence sets for forecasting models

    OpenAIRE

    Hansen, Peter Reinhard; Lunde, Asger; Nason, James M.

    2005-01-01

    The paper introduces the model confidence set (MCS) and applies it to the selection of forecasting models. An MCS is a set of models that is constructed so that it will contain the “best” forecasting model, given a level of confidence. Thus, an MCS is analogous to a confidence interval for a parameter. The MCS acknowledges the limitations of the data so that uninformative data yield an MCS with many models, whereas informative data yield an MCS with only a few models. We revisit the empirical...

  2. Business Model Innovation

    OpenAIRE

    Dodgson, Mark; Gann, David; Phillips, Nelson; Massa, Lorenzo; Tucci, Christopher

    2014-01-01

    The chapter offers a broad review of the literature at the nexus between Business Models and innovation studies, and examines the notion of Business Model Innovation in three different situations: Business Model Design in newly formed organizations, Business Model Reconfiguration in incumbent firms, and Business Model Innovation in the broad context of sustainability. Tools and perspectives to make sense of Business Models and support managers and entrepreneurs in dealing with Business Model ...

  3. Mathematical modeling of plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Dnestrovskii, Iu.N.; Kostomarov, D.P.

    1982-01-01

    Problems related to the mathematical modeling of high-temperature plasmas are discussed with particular reference to controlled nuclear fusion. Attention is given to the modeling of kinetic processes with Coulomb interaction, the modeling of magnetohydrodynamic processes, transport models, and hybrid models. The discussion covers the principal mathematical models, the statement of problems, and numerical methods of solution. Consideration is also given to the analysis of the physical results obtained by mathematical modeling. 7 references.

  4. Modeling, computation and optimization

    CERN Document Server

    Neogy, S K

    2009-01-01

    This volume provides recent developments and a state-of-the-art review in various areas of mathematical modeling, computation and optimization. It contains theory, computation as well as the applications of several mathematical models to problems in statistics, games, optimization and economics for decision making. It focuses on exciting areas like models for wireless networks, models of Nash networks, dynamic models of advertising, application of reliability models in economics, support vector machines, optimization, complementarity modeling and games.

  5. Product and Process Modelling

    DEFF Research Database (Denmark)

    Cameron, Ian T.; Gani, Rafiqul

    2011-01-01

    This book covers the area of product and process modelling via a case study approach. It addresses a wide range of modelling applications with emphasis on modelling methodology and the subsequent in-depth analysis of mathematical models to gain insight via structural aspects of the models. These approaches are put into the context of life cycle modelling, where multiscale and multiform modelling is increasingly prevalent in the 21st century. The book commences with a discussion of modern product...

  6. Geoscientific Model Development - a journal about models, for modellers

    Science.gov (United States)

    Lunt, Daniel; Annan, James; Hargreaves, Julia; Rutt, Ian; Sander, Rolf

    2010-05-01

    The journal Geoscientific Model Development arose from the observation that despite modelling being central to climate/earth system science, the models themselves are not generally subject to the same level of scrutiny and peer review as the results they generate. Model descriptions are generally (with some exceptions) difficult to publish independent from scientific results, and so are necessarily space-limited when they do appear. Consequently, it is not uncommon that the description of a given model is spread across several papers, and crucial aspects of the formulation may not be published at all. Issues of reproducibility, platform-dependence, version proliferation and the various fudges and corrections often needed in modelling, are rarely addressed in the literature. GMD aims to change this by providing a place to publish detailed, peer-reviewed descriptions of numerical models, including verification and validation. Model developers can publish an initial description of a numbered version of their model, and address subsequent changes with a sequence of update papers. Thus, a body of citable literature can be developed which provides an authoritative reference for a given version of the model, greatly improving traceability and giving confidence in the provenance of the code. An additional benefit is that the citations generated will at last recognise the important contribution which model developers make to science. The publication process is typical for an open access EGU journal: papers are initially published in an on-line discussion journal (Geoscientific Model Development Discussions), for a period of eight weeks. Anonymous reviews are solicited as normal, but are also published in the discussion journal. Anyone else may contribute to the discussions, if they wish. After the discussion period, the revision/review process operates as normal, until the paper is finally accepted or rejected by the handling topical editor. In this paper we describe the journal, and present statistics of submissions, papers accepted etc. since its first issue in 2008. For more details, see http://www.geoscientific-model-development.net

  7. Wake modelling combining mesoscale and microscale models

    DEFF Research Database (Denmark)

    Badger, Jake; Volker, Patrick

    2013-01-01

    In this paper the basis for introducing thrust information from microscale wake models into mesocale model wake parameterizations will be described. A classification system for the different types of mesoscale wake parameterizations is suggested and outlined. Four different mesoscale wake parameterizations are demonstrated in theWeather Research and Forecasting mesoscale model (WRF) in an idealized atmospheric flow. The model framework is the Horns Rev I wind farm experiencing an 7.97 m/s wind from 269.4o. Three of the four parameterizations use thrust output from the CRESflow-NS microscale model. The characteristics of the mesoscale wake that developed from the four parameterizations are examined. In addition the mesoscale model wakes are compared to measurement data from Horns Rev I. Overall it is seen as an advantage to incorporate microscale model data in mesocale model wake parameterizations.

  8. A Note on the Phase Locking Value and its Properties

    OpenAIRE

    Aydore, Sergul; Pantazis, Dimitrios; Leahy, Richard M.

    2013-01-01

    We investigate the properties of the Phase Locking Value (PLV) and the Phase Lag Index (PLI) as metrics for quantifying interactions in bivariate local field potential (LFP), electroencephalography (EEG) and magnetoencephalography (MEG) data. In particular we describe the relationship between nonparametric estimates of PLV and PLI and the parameters of two distributions that can both be used to model phase interactions. The first of these is the von Mises distribution, for which the sample PL...

  9. Acute effects of alcohol on stimulus-induced gamma oscillations in human primary visual and motor cortices

    OpenAIRE

    Campbell, Anne Eileen; Sumner, Petroc; Singh, Krish D; Muthukumaraswamy, Suresh D.

    2014-01-01

    Alcohol is a rich drug affecting both the ?-amino butyric acid (GABA) and glutamatergic neurotransmitter systems. Recent findings from both modelling and pharmacological manipulation have indicated a link between GABAergic activity and oscillations measured in the gamma frequency range (30-80Hz), but there are no previous reports of alcohol’s modulation of gamma-band activity measured by magnetoencephalography (MEG) or electroencephalography (EEG). In this single-blind, placebo-controlled cro...

  10. Model selection for logistic regression models

    Science.gov (United States)

    Duller, Christine

    2012-09-01

    Model selection for logistic regression models decides which of some given potential regressors have an effect and hence should be included in the final model. The second interesting question is whether a certain factor is heterogeneous among some subsets, i.e. whether the model should include a random intercept or not. In this paper these questions will be answered with classical as well as with Bayesian methods. The application show some results of recent research projects in medicine and business administration.

  11. Wake modelling combining mesoscale and microscale models

    DEFF Research Database (Denmark)

    Badger, Jake; Volker, Patrick; Prospathospoulos, J.; Sieros, G.; Ott, Søren; Réthoré, Pierre-Elouan; Hahmann, Andrea N.; Hasager, Charlotte Bay

    2013-01-01

    In this paper the basis for introducing thrust information from microscale wake models into mesocale model wake parameterizations will be described. A classification system for the different types of mesoscale wake parameterizations is suggested and outlined. Four different mesoscale wake parameterizations are demonstrated in theWeather Research and Forecasting mesoscale model (WRF) in an idealized atmospheric flow. The model framework is the Horns Rev I wind farm experiencing an 7.97 m/s wind f...

  12. Mapping DEVS Models onto UML Models

    OpenAIRE

    Zinoviev, Dmitry

    2005-01-01

    Discrete event simulation specification (DEVS) is a formalism designed to describe both discrete state and continuous state systems. It is a powerful abstract mathematical notation. However, until recently it lacked proper graphical representation, which made computer simulation of DEVS models a challenging issue. Unified modeling language (UML) is a multipurpose graphical modeling language, a de-facto industrial modeling standard. There exist several commercial and open-sou...

  13. Model Checking of Boolean Process Models

    OpenAIRE

    Schneider, Christoph; Wehler, Joachim

    2011-01-01

    In the field of Business Process Management formal models for the control flow of business processes have been designed since more than 15 years. Which methods are best suited to verify the bulk of these models? The first step is to select a formal language which fixes the semantics of the models. We adopt the language of Boolean systems as reference language for Boolean process models. Boolean systems form a simple subclass of coloured Petri nets. Their characteristics are low tokens to mode...

  14. From Numeric Models to Granular System Modeling

    OpenAIRE

    Witold Pedrycz

    2015-01-01

    In the era of advanced methodologies and practices of system modeling, we are faced with ever growing challenges of building models of complex systems that are in full rapport with reality. These challenges are multifaceted. Human centricity becomes of paramount relevance in system modeling and because of this models need to be customized and easily interpretable. More and more visibly, experimental data and knowledge of varying quality being directly acquired from experts have to be efficien...

  15. Modeling transient rootzone salinity (SWS Model)

    Science.gov (United States)

    The combined, water quality criteria for irrigation, water and ion processes in soils, and plant and soil response is sufficiently complex that adequate analysis requires computer models. Models for management are also needed but these models must consider that the input requirements must be reasona...

  16. Molecular Models: Construction of Models with Magnets

    Directory of Open Access Journals (Sweden)

    Kalinov?i? P.

    2015-07-01

    Full Text Available Molecular models are indispensable tools in teaching chemistry. Beside their high price, commercially available models are generally too small for classroom demonstration. This paper suggests how to make space-filling (callote models from Styrofoam with magnetic balls as connectors and disc magnets for showing molecular polarity

  17. China model: Energy modeling the modern dynasty

    Energy Technology Data Exchange (ETDEWEB)

    Shaw, Jason [Binghamton Univ., NY (United States)

    1996-05-01

    In this paper a node-based microeconomic analysis is used to model the Chinese energy system. This model is run across multiple periods employing Lagrangian Relaxation techniques to achieve general equilibrium. Later, carbon dioxide emissions are added and the model is run to answer the question, {open_quotes}How can greenhouse gas emissions be reduced{close_quotes}?

  18. Calogero Model(s and Deformed Oscillators

    Directory of Open Access Journals (Sweden)

    Marijan Milekovic

    2006-03-01

    Full Text Available We briefly review some recent results concerning algebraical (oscillator aspects of the N-body single-species and multispecies Calogero models in one dimension. We show how these models emerge from the matrix generalization of the harmonic oscillator Hamiltonian. We make some comments on the solvability of these models.

  19. QSMSR QUALITATIVE MODEL

    Directory of Open Access Journals (Sweden)

    Tahir Abdullah

    2012-02-01

    Full Text Available Software architecture design and requirement engineering are core and independent areas of engineering. A lot of research, education and practice are carried on Requirement elicitation and doing refine it, but it is a major issue of engineering. QSMSR model act as a bridge between requirement and design there is a huge gap between these two areas of software architecture and requirement engineering. The QSMSR model divide into two sub model qualitative model and Principal model in this research we focus on Qualitative model which further divide into two sub models fabricated model and classified model. Classified model make the sub groups of the role and match it with components. The Fabricated model link QSMSR Principal Model to an architecture design. At the end it provides the QSMSR Architecture model of the system as output.

  20. QVT transformation by modelling - From UML Model to MD Model

    OpenAIRE

    M.Erramdani; I.Arrassen; Meziane, A.; R.Sbai

    2011-01-01

    To provide a complete analysis of the organization, its business and its needs, it is necessary for leaders to have data that help decision making. Data warehouses are designed to meet such needs; they are an analysis and data management technology. This article describes an MDA (Model Driven Architecture) process that we have used to automatically generate the multidimensional schema of data warehouse. This process uses model transformation using several standards such as Unified Modeling La...

  1. Automated data model evaluation

    International Nuclear Information System (INIS)

    Modeling process is essential phase within information systems development and implementation. This paper presents methods and techniques for analysis and evaluation of data model correctness. Recent methodologies and development results regarding automation of the process of model correctness analysis and relations with ontology tools has been presented. Key words: Database modeling, Data model correctness, Evaluation

  2. Modelling of Hydraulic Robot

    DEFF Research Database (Denmark)

    Madsen, Henrik; Zhou, Jianjun; Hansen, Lars Henrik

    1997-01-01

    This paper describes a case study of identifying the physical model (or the grey box model) of a hydraulic test robot. The obtained model is intended to provide a basis for model-based control of the robot. The physical model is formulated in continuous time and is derived by application of the...

  3. Semantic Business Process Modeling

    OpenAIRE

    Markovic, Ivan

    2010-01-01

    This book presents a process-oriented business modeling framework based on semantic technologies. The framework consists of modeling languages, methods, and tools that allow for semantic modeling of business motivation, business policies and rules, and business processes. Quality of the proposed modeling framework is evaluated based on the modeling content of SAP Solution Composer and several real-world business scenarios.

  4. From Numeric Models to Granular System Modeling

    Directory of Open Access Journals (Sweden)

    Witold Pedrycz

    2015-03-01

    To make this study self-contained, we briefly recall the key concepts of granular computing and demonstrate how this conceptual framework and its algorithmic fundamentals give rise to granular models. We discuss several representative formal setups used in describing and processing information granules including fuzzy sets, rough sets, and interval calculus. Key architectures of models dwell upon relationships among information granules. We demonstrate how information granularity and its optimization can be regarded as an important design asset to be exploited in system modeling and giving rise to granular models. With this regard, an important category of rule-based models along with their granular enrichments is studied in detail.

  5. Environmental sub models for a macroeconomic model

    DEFF Research Database (Denmark)

    Jensen, Trine S.; Jensen, Jørgen Dejgård; Hasler, Berit; Illerup, Jytte B.; Andersen, Frits M.

    2006-01-01

    plans, etc. In this article an integrated model system is extended to include emissions of the greenhouse gasses, CH4 and N2O and the acidifying substance, NH3, from the Danish agricultural production. The model system comprises a macroeconomic model of the Danish economy, a Danish agricultural sector...... emission coefficients is described. Emission dependent parameters are identified in order to perform model projections. The model system is demonstrated by projections of agricultural-related emissions in Denmark under two alternative sets of assumptions: a baseline projection and a policy scenario for...

  6. Building mental models by dissecting physical models.

    Science.gov (United States)

    Srivastava, Anveshna

    2016-01-01

    When students build physical models from prefabricated components to learn about model systems, there is an implicit trade-off between the physical degrees of freedom in building the model and the intensity of instructor supervision needed. Models that are too flexible, permitting multiple possible constructions require greater supervision to ensure focused learning; models that are too constrained require less supervision, but can be constructed mechanically, with little to no conceptual engagement. We propose "model-dissection" as an alternative to "model-building," whereby instructors could make efficient use of supervisory resources, while simultaneously promoting focused learning. We report empirical results from a study conducted with biology undergraduate students, where we demonstrate that asking them to "dissect" out specific conceptual structures from an already built 3D physical model leads to a significant improvement in performance than asking them to build the 3D model from simpler components. Using questionnaires to measure understanding both before and after model-based interventions for two cohorts of students, we find that both the "builders" and the "dissectors" improve in the post-test, but it is the latter group who show statistically significant improvement. These results, in addition to the intrinsic time-efficiency of "model dissection," suggest that it could be a valuable pedagogical tool. © 2015 by The International Union of Biochemistry and Molecular Biology, 44:7-11, 2016. PMID:26712513

  7. Environmental Satellite Models for a Macroeconomic Model

    International Nuclear Information System (INIS)

    To support national environmental policy, it is desirable to forecast and analyse environmental indicators consistently with economic variables. However, environmental indicators are physical measures linked to physical activities that are not specified in economic models. One way to deal with this is to develop environmental satellite models linked to economic models. The system of models presented gives a frame of reference where emissions of greenhouse gases, acid gases, and leaching of nutrients to the aquatic environment are analysed in line with - and consistently with - macroeconomic variables. This paper gives an overview of the data and the satellite models. Finally, the results of applying the model system to calculate the impacts on emissions and the economy are reviewed in a few illustrative examples. The models have been developed for Denmark; however, most of the environmental data used are from the CORINAIR system implemented in numerous countries

  8. Armas estratégicas e poder no sistema internacional: o advento das armas de energia direta e seu impacto potencial sobre a guerra e a distribuição multipolar de capacidades Strategic weapons and power in international system: the arise of direct energy weapons and their potential impact over the war and multipolar distribution of capabilities

    Directory of Open Access Journals (Sweden)

    Fabrício Schiavo Ávila

    2009-04-01

    Full Text Available O pós-Guerra Fria (1991-2006 apresenta uma mudança significativa no cenário estratégico: a maior acessibilidade da tecnologia militar e o surgimento de novas armas capazes de modificar o poder coercitivo dos países - como as armas de energia direta - acabam pondo em xeque a ideia de que a primazia nuclear é condição suficiente para garantir a unipolaridade. Focando-se no atual recrudescimento das tensões entre EUA e Rússia - especialmente com a proposta norte-americana de implementação do Escudo Antimíssil no Leste Europeu - e analisando as relações de poder entre os três países, procuramos revelar que tipo de competição ocorrerá no sistema internacional nas próximas décadas. O presente artigo analisa as reais possibilidades de que a primazia nuclear norte-americana se torne efetiva, uma vez que, para tanto, é necessário o desarmamento estratégico das demais potências. Como uma guerra nuclear entre os três países possui um custo político muito elevado, as disputas tendem a ser decididas na esfera das operações. Para ilustrar esta última afirmação, usamos um cenário contrafactual de guerra nuclear limitada entre Estados Unidos, Rússia e China, por meio do qual tentamos evidenciar as precondições táticas e operacionais para uma eventual vitória da coalizão sino-russa.The evolution of the Post-Cold War (1991-2006 international system shows a significant amount of change regarding the strategic capabilities of United States, Russia, and China. The rise of a new class of strategic weapons called directed energy weapons (lasers and high power microwaves, as well as the great costs associated with the quest for nuclear primacy, demand closer examination of the current assumption about the links between nuclear primacy and unipolar distribution of power in the International System. Starting with the current tensions between US and Russia, we try to reveal in this article what kind of competition might be observed in the international system over the next decade. The present work analyzes the real possibilities of the USA achieving an effective nuclear primacy condition, which requires the complete disarmament of all other powers. Since a nuclear war between the three countries has a very high political cost, disputes tend to be settled on the operational sphere. In order to demonstrate this final point, we made comparative use of two nuclear war scenarios. The article concludes by establishing the tactical and operational conditions that Russia and China seems to counting with in order to defeat United States if a shooting war comes.

  9. Armas estratégicas e poder no sistema internacional: o advento das armas de energia direta e seu impacto potencial sobre a guerra e a distribuição multipolar de capacidades / Strategic weapons and power in international system: the arise of direct energy weapons and their potential impact over the war and multipolar distribution of capabilities

    Scientific Electronic Library Online (English)

    Fabrício Schiavo, Ávila; José Miguel, Martins; Marco, Cepik.

    2009-04-01

    Full Text Available O pós-Guerra Fria (1991-2006) apresenta uma mudança significativa no cenário estratégico: a maior acessibilidade da tecnologia militar e o surgimento de novas armas capazes de modificar o poder coercitivo dos países - como as armas de energia direta - acabam pondo em xeque a ideia de que a primazia [...] nuclear é condição suficiente para garantir a unipolaridade. Focando-se no atual recrudescimento das tensões entre EUA e Rússia - especialmente com a proposta norte-americana de implementação do Escudo Antimíssil no Leste Europeu - e analisando as relações de poder entre os três países, procuramos revelar que tipo de competição ocorrerá no sistema internacional nas próximas décadas. O presente artigo analisa as reais possibilidades de que a primazia nuclear norte-americana se torne efetiva, uma vez que, para tanto, é necessário o desarmamento estratégico das demais potências. Como uma guerra nuclear entre os três países possui um custo político muito elevado, as disputas tendem a ser decididas na esfera das operações. Para ilustrar esta última afirmação, usamos um cenário contrafactual de guerra nuclear limitada entre Estados Unidos, Rússia e China, por meio do qual tentamos evidenciar as precondições táticas e operacionais para uma eventual vitória da coalizão sino-russa. Abstract in english The evolution of the Post-Cold War (1991-2006) international system shows a significant amount of change regarding the strategic capabilities of United States, Russia, and China. The rise of a new class of strategic weapons called directed energy weapons (lasers and high power microwaves), as well a [...] s the great costs associated with the quest for nuclear primacy, demand closer examination of the current assumption about the links between nuclear primacy and unipolar distribution of power in the International System. Starting with the current tensions between US and Russia, we try to reveal in this article what kind of competition might be observed in the international system over the next decade. The present work analyzes the real possibilities of the USA achieving an effective nuclear primacy condition, which requires the complete disarmament of all other powers. Since a nuclear war between the three countries has a very high political cost, disputes tend to be settled on the operational sphere. In order to demonstrate this final point, we made comparative use of two nuclear war scenarios. The article concludes by establishing the tactical and operational conditions that Russia and China seems to counting with in order to defeat United States if a shooting war comes.

  10. Geologic Framework Model Analysis Model Report

    International Nuclear Information System (INIS)

    The purpose of this report is to document the Geologic Framework Model (GFM), Version 3.1 (GFM3.1) with regard to data input, modeling methods, assumptions, uncertainties, limitations, and validation of the model results, qualification status of the model, and the differences between Version 3.1 and previous versions. The GFM represents a three-dimensional interpretation of the stratigraphy and structural features of the location of the potential Yucca Mountain radioactive waste repository. The GFM encompasses an area of 65 square miles (170 square kilometers) and a volume of 185 cubic miles (771 cubic kilometers). The boundaries of the GFM were chosen to encompass the most widely distributed set of exploratory boreholes (the Water Table or WT series) and to provide a geologic framework over the area of interest for hydrologic flow and radionuclide transport modeling through the unsaturated zone (UZ). The depth of the model is constrained by the inferred depth of the Tertiary-Paleozoic unconformity. The GFM was constructed from geologic map and borehole data. Additional information from measured stratigraphy sections, gravity profiles, and seismic profiles was also considered. This interim change notice (ICN) was prepared in accordance with the Technical Work Plan for the Integrated Site Model Process Model Report Revision 01 (CRWMS M and O 2000). The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. The GFM is one component of the Integrated Site Model (ISM) (Figure l), which has been developed to provide a consistent volumetric portrayal of the rock layers, rock properties, and mineralogy of the Yucca Mountain site. The ISM consists of three components: (1) Geologic Framework Model (GFM); (2) Rock Properties Model (RPM); and (3) Mineralogic Model (MM). The ISM merges the detailed project stratigraphy into model stratigraphic units that are most useful for the primary downstream models and the repository design. These downstream models include the hydrologic flow models and the radionuclide transport models. All the models and the repository design, in turn, will be incorporated into the Total System Performance Assessment (TSPA) of the potential radioactive waste repository block and vicinity to determine the suitability of Yucca Mountain as a host for the repository. The interrelationship of the three components of the ISM and their interface with downstream uses are illustrated in Figure 2

  11. Geologic Framework Model Analysis Model Report

    Energy Technology Data Exchange (ETDEWEB)

    R. Clayton

    2000-12-19

    The purpose of this report is to document the Geologic Framework Model (GFM), Version 3.1 (GFM3.1) with regard to data input, modeling methods, assumptions, uncertainties, limitations, and validation of the model results, qualification status of the model, and the differences between Version 3.1 and previous versions. The GFM represents a three-dimensional interpretation of the stratigraphy and structural features of the location of the potential Yucca Mountain radioactive waste repository. The GFM encompasses an area of 65 square miles (170 square kilometers) and a volume of 185 cubic miles (771 cubic kilometers). The boundaries of the GFM were chosen to encompass the most widely distributed set of exploratory boreholes (the Water Table or WT series) and to provide a geologic framework over the area of interest for hydrologic flow and radionuclide transport modeling through the unsaturated zone (UZ). The depth of the model is constrained by the inferred depth of the Tertiary-Paleozoic unconformity. The GFM was constructed from geologic map and borehole data. Additional information from measured stratigraphy sections, gravity profiles, and seismic profiles was also considered. This interim change notice (ICN) was prepared in accordance with the Technical Work Plan for the Integrated Site Model Process Model Report Revision 01 (CRWMS M&O 2000). The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. The GFM is one component of the Integrated Site Model (ISM) (Figure l), which has been developed to provide a consistent volumetric portrayal of the rock layers, rock properties, and mineralogy of the Yucca Mountain site. The ISM consists of three components: (1) Geologic Framework Model (GFM); (2) Rock Properties Model (RPM); and (3) Mineralogic Model (MM). The ISM merges the detailed project stratigraphy into model stratigraphic units that are most useful for the primary downstream models and the repository design. These downstream models include the hydrologic flow models and the radionuclide transport models. All the models and the repository design, in turn, will be incorporated into the Total System Performance Assessment (TSPA) of the potential radioactive waste repository block and vicinity to determine the suitability of Yucca Mountain as a host for the repository. The interrelationship of the three components of the ISM and their interface with downstream uses are illustrated in Figure 2.

  12. Wildfire Risk Main Model

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — The model combines three modeled fire behavior parameters (rate of spread, flame length, crown fire potential) and one modeled ecological health measure (fire...

  13. Predictive Models for Music

    OpenAIRE

    Paiement, Jean-François; Grandvalet, Yves; Bengio, Samy

    2008-01-01

    Modeling long-term dependencies in time series has proved very difficult to achieve with traditional machine learning methods. This problem occurs when considering music data. In this paper, we introduce generative models for melodies. We decompose melodic modeling into two subtasks. We first propose a rhythm model based on the distributions of distances between subsequences. Then, we define a generative model for melodies given chords and rhythms based on modeling sequences of Narmour featur...

  14. On Model Subtyping

    OpenAIRE

    Guy, Clément; Combemale, Benoit; Derrien, Steven; Steel, James,; Jézéquel, Jean-Marc

    2012-01-01

    Various approaches have recently been proposed to ease the manipulation of models for specific purposes (e.g., automatic model adaptation or reuse of model transformations). Such approaches raise the need for a unified theory that would ease their combination, but would also outline the scope of what can be expected in terms of engineering to put model manipulation into action. In this work, we address this problem from the model substitutability point of view, through model typing. We introd...

  15. Modeling of geothermal systems

    Energy Technology Data Exchange (ETDEWEB)

    Bodvarsson, G.S.; Pruess, K.; Lippmann, M.J.

    1985-03-01

    During the last decade the use of numerical modeling for geothermal resource evaluation has grown significantly, and new modeling approaches have been developed. In this paper we present a summary of the present status in numerical modeling of geothermal systems, emphasizing recent developments. Different modeling approaches are described and their applicability discussed. The various modeling tasks, including natural-state, exploitation, injection, multi-component and subsidence modeling, are illustrated with geothermal field examples. 99 refs., 14 figs.

  16. Global Business Models

    DEFF Research Database (Denmark)

    Rask, Morten

    insight from the literature about business models, international product policy, international entry modes and globalization into a conceptual model of relevant design elements of global business models, enabling global business model innovation to deal with differences in a downstream perspective...... regarding the customer interface and in an upstream perspective regarding the supply infrastructure. The paper offers a coherent conceptual dynamic meta-model of global business model innovation. Students, scholars and managers within the field of international business can use this conceptualization to...

  17. Computational neurogenetic modeling

    CERN Document Server

    Benuskova, Lubica

    2010-01-01

    Computational Neurogenetic Modeling is a student text, introducing the scope and problems of a new scientific discipline - Computational Neurogenetic Modeling (CNGM). CNGM is concerned with the study and development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes. These include neural network models and their integration with gene network models. This new area brings together knowledge from various scientific disciplines, such as computer and information science, neuroscience and cognitive science, genetics and molecular biol

  18. Modelling Food Webs

    CERN Document Server

    Drossel, B

    2002-01-01

    We review theoretical approaches to the understanding of food webs. After an overview of the available food web data, we discuss three different classes of models. The first class comprise static models, which assign links between species according to some simple rule. The second class are dynamical models, which include the population dynamics of several interacting species. We focus on the question of the stability of such webs. The third class are species assembly models and evolutionary models, which build webs starting from a few species by adding new species through a process of "invasion" (assembly models) or "speciation" (evolutionary models). Evolutionary models are found to be capable of building large stable webs.

  19. TRACKING CLIMATE MODELS

    Data.gov (United States)

    National Aeronautics and Space Administration — CLAIRE MONTELEONI*, GAVIN SCHMIDT, AND SHAILESH SAROHA* Climate models are complex mathematical models designed by meteorologists, geophysicists, and climate...

  20. Simplicity, complexity and modelling

    CERN Document Server

    Christie, Mike; Dawid, Philip; Senn, Stephen S

    2011-01-01

    Several points of disagreement exist between different modelling traditions as to whether complex models are always better than simpler models, as to how to combine results from different models and how to propagate model uncertainty into forecasts. This book represents the result of collaboration between scientists from many disciplines to show how these conflicts can be resolved. Key Features: Introduces important concepts in modelling, outlining different traditions in the use of simple and complex modelling in statistics. Provides numerous case studies on complex modelling, such as c