International Nuclear Information System (INIS)

In vitro cytocompatibility and cellular interactions of lauric acid and dextran-coated magnetite nanoparticles were evaluated with two different cell lines (mouse fibroblast and human cervical carcinoma). Lauric acid-coated magnetite nanoparticles were less cytocompatible than dextran-coated magnetite nanoparticles and cellular uptake of lauric acid-coated magnetic nanoparticles was more than that of dextran-coated magnetite nanoparticles. Lesser cytocompatibility and higher uptake of lauric acid-coated magnetite nanoparticles as compared to dextran-coated magnetic nanoparticles may be due to different cellular interactions by coating material. Thus, coating plays an important role in modulation of biocompatibility and cellular interaction of magnetic nanoparticles.

Energy Technology Data Exchange (ETDEWEB)

The existence of multipole components in the dipole and quadrupole magnets is one of the factors limiting the beam stability in the RHIC operations. So, a realistic non-linear model is crucial for understanding the beam behavior and to achieve the ultimate performance in RHIC. A procedure is developed to build a non-linear model using the available multipole component data obtained from measurements of RHIC magnets. We first discuss the measurements performed at different stages of manufacturing of the magnets in relation to their current state in RHIC. We then describe the procedure to implement these measurement data into tracking models, including the implementation of the multipole feed down effect due to the beam orbit offset from the magnet center. Finally, the field quality analysis in the RHIC interaction regions (IR) is presented.

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In this article a production method of a magnetorheological suspension composed with silicon steel particles of size 0.1-0.15 mm and 4% silicon content is described. Steel particles were dispersed in a conducting carrier of a by mixture of graphite particles with size 2-5 {mu}m and cedar wood oil. The filling factor of the suspension with the silicon steel particles and with graphite particles amounted to 0.25-0.40. Samples of this suspension were placed in a rectangular vessel with electrodes and used for the investigation of the Hall effect in magnetic field with induction 0-8 T, generated by Bitter-type magnet. A non-linear dependence of Hall voltage on the induction of the applied magnetic field and a hysteresis loop of this voltage in the shape of inclined digit eight were found. The causes of the observed effects is the ordering of silicon steel particles and graphite particles along the side of ...

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Using the Relativistic Mean Field Theory (RMF) it is shown that different proton fraction which is directly connected with the neutron excess and with the asymmetry of the system affects proto-neutron stars parameters and changes their composition. The obtained form of the equation of state allows to construct the mass-radius relations and shows that the increasing asymmetry creates more compact stars. The inclusion of {delta} meson together with nonlinear vector meson interaction terms and magnetic field make this effect even stronger.

International Nuclear Information System (INIS)

We have studied the features of formation and the possible stationary structures of a self-consistent magnetic field in a relativistic collisionless plasma, which are characteristic of a simple geometry of the Weibel instability that is well known in the nonrelativistic case. The universal condition is established, the growth rate is determined, and the criteria of saturation of the Weibel instability are analyzed for a broad class of anisotropic particle distribution functions (for definiteness, in application to an electron-positron plasma). A nonlinear equation of the Grad-Shafranov type describing the potential current structures is derived and its solutions are analytically studied. Special attention is paid to spatially harmonic, nonlinear current configurations with parameters determined by the properties of the initial homogeneous plasma subject to the Weibel instability. It is demonstrated that the ...

CERN Document Server

Magnetic fields appear to be a generic feature of the early universe and are a natural source of secondary CMB non-Gaussianity. In recent years the statistical nature of the stresses of a primordial magnetic field has been well studied. In this paper we confirm and extend these studies at one- and two-point level, and present analytical results for a wide range of power-law spectra. We also consider two non-power law cases of interest: a blue spectrum with an extended damping tail on small scales, which could be generated by the non-linear mixing of density and vorticity; and a red spectrum with a damping tail on large scales. We then briefly consider the CMB impacts that result from such fields. While this paper focuses on the one- and two-point moments, the techniques we employ are designed to ease the analysis of the full bispectra induced by primordial magnetic fields.

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A non-linear analysis of a Cerenkov maser is presented. The system consists of a ring configuration of a cylindrical waveguide filled with a dielectric material. A single transverse-magnetic mode is assumed to propagate in the system. A low-density pencil electron beam travels in part of the ring, confined by a strong axial magnetic field. Using the single-particle description for the beam and the wave equation for the field, we obtain a set of two coupled non-linear differential equations describing the slowly varying amplitude and phase of the electromagnetic mode. The gain per path is assumed to be small and the spatial growth of the field is neglected. The resulting time dependent amplitude includes the exponential gain of the linear stage and the saturation to its maximum value. The time dependent frequency is also calculated. The two equations are combined to a single Van Der Pol equation with a ...

International Nuclear Information System (INIS)

The most propagated mechanisms of stimulated radiation of electron beam such as Cherenkov one-particle and collective effects, ondulator and magnetic bremsshrahlung radiations, Doppler anomalous effect, Thompson and Raman scattering and radiation are discussed. Relation of spontaneous radiation mechanisms of individual electron and stimulated radiation effects in electron beams has been elucidated, grounds of linear electrodynamics of radiative beam instabilities are stated, and main mechanisms of their nonlinear stabilization are elucidated as well. Various simulated processes in electron beams are considered from the unique point of view using a simple mathematical apparatus and such physical laws as conservation and Newton laws.

International Nuclear Information System (INIS)

Computer programs have been developed for modelling impedance and transmit-receive eddy current probes in two-dimensional axis-symmetric configurations. These programs, which are based on analytic equations, simulate bobbin probes in infinitely long tubes and surface probes on plates. They calculate probe signal due to uniform variations in conductor thickness, resistivity and permeability. These signals depend on probe design and frequency. A finite element numerical program has been procured to calculate magnetic permeability in non-linear ferromagnetic materials. Permeability values from these calculations can be incorporated into the above analytic programs to predict signals from eddy current probes with permanent magnets in ferromagnetic tubes. These programs were used to test various probe designs for new testing applications. Measurements of magnetic permeability in ...

CERN Document Server

Regulatory genes called small RNAs (sRNAs) are known to play critical roles in cellular responses to changing environments. For several sRNAs, regulation is effected by coupled stoichiometric degradation with messenger RNAs (mRNAs). The nonlinearity inherent in this regulatory scheme indicates that exact analytical solutions for the corresponding stochastic models are intractable. Here, we present a variational approach to analyze a well-studied stochastic model for regulation by sRNAs via coupled degradation. The proposed approach is efficient and provides accurate estimates of mean mRNA levels as well as higher order terms. Results from the variational ansatz are in excellent agreement with data from stochastic simulations for a wide range of parameters, including regions of parameter space where mean-field approaches break down. The proposed approach can be applied to quantitatively model stochastic gene expression in complex regulatory ...

International Nuclear Information System (INIS)

The polycrystalline samples of Y_2_-_xHo_xO_3 (0.10#<=#x#<=#1.80) were synthesized by ceramic technology. The X-ray powder diffraction data were collected and the crystal structures were refined by the Rietveld method for the samples Y_2_-_xHo_xO_3 (x=0.00, 0.20, 0.40, 1.20, 1.80, 2.00). Holmium ions Ho"3"+ were randomly distributed over two cationic sites 8b and 24d in the space group Ia3 in all refined structures. Cation-anion-cation bonds important for superexchange interaction were determined. Magnetic susceptibility measurements were done by the Faraday method in the temperature range 290 to 620 K and a behaviour in accordance with the Curie-Weiss law was obtained. The molar Curie's constants linearly depend on concentration. The effective magnetic moments of Ho"3"+ ions were smaller than the free ion value. The Curie-Weiss paramagnetic temperatures indicated antiferromagnetic interaction. The gram ion susceptibilities confirmed the ...

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The radio, optical, x-ray and gamma-ray nebulae that surround many pulsars are thought to arise from synchrotron and inverse Compton emission. The energy powering this emission as well as the magnetic fields and relativistic particles are supplied by a 'wind' driven by the central object. The inner parts of the wind can be described using the equations of MHD, but these break down in the outer parts, when the density of charge carriers drops below a critical value. This paper reviews the wave properties of the inner part (striped wind), and uses a relativistic two-fluid model (cold electrons and positrons) to re-examine the nonlinear electromagnetic modes that propagate in the outer parts. It is shown that in a radial wind, two solutions exist for circularly polarized electromagnetic modes. At large distances one of them turns into a freely expanding flow containing a vacuum wave, whereas the other decelerates, corresponding to a confined flow.

British Library Electronic Table of Contents (United Kingdom)

In this article, we studied the effects of variable viscosity and thermal conductivity on an unsteady two-dimensional laminar flow of a viscous incompressible conducting fluid past a semi-infinite vertical porous moving plate taking into account the effect of a magnetic field in the presence of variable suction. The fluid viscosity is assumed to vary as an inverse linear function of temperature but the thermal conductivity is assumed to vary as a linear function of temperature. It is assumed that the porous plate moves with a constant velocity in the direction of fluid flow, and the free stream velocity follows the exponentially increasing small perturbation law. The governing equations for the flow are transformed into a system of nonlinear ordinary differential equations by perturbation ...

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Inspired by the recent realizations of quantum dot (QD)-DNA conjugation, we study the spectral density of a magnetic impurity coupled to a mesoscopic semiconducting host. Using a combination of exact diagonalization technique and an analytic approach, we demonstrate that various types of resonances occur according to the relative position of impurity levels (IL) with respect to the host levels (HL). While the usual Coulomb peaks appear when the IL lie inside a band gap, with IL approaching HL and hybridization activated, they shift nonlinearly with the repulsion strength and even undergo splitting for a strong hybridization. When IL merge into HL, multiple resonances of a comblike structure are found along with a parity effect.

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In this study we discuss an unsteady free convection MHD flow past semi-infinite vertical porous plate. We have considered the flow in the presence of a strong magnetic field and therefore the electromagnetic force is very large. This brings in the phenomenon of Hall and Ion-slip currents. The effects of these two parameters together with that of viscous dissipation and radiation absorption among others on velocity, temperature and concentration profiles are presented. The profiles are presented graphically. As the partial differential equations governing this problem are highly non-linear they are solved numerically by a finite difference method. It is found that in presence of heating of the plate by free convection current the velocity boundary layer thickness decreases.

UK PubMed Central (United Kingdom)

We present the formulation and testing of a mathematical model for the kinetics of homotypic cellular aggregation. The model considers cellular aggregation under no-flow conditions as a two-step process....Full Text Available

UK PubMed Central (United Kingdom)

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which...Full Text Available

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... range magnetic fields magnetic susceptibility magnetization neutron diffraction

Energy Technology Data Exchange (ETDEWEB)

Objective: To compare the histopathology of nodular fasciitis (NF) with the magnetic resonance imaging (MRI) findings in order to evaluate the basis of the MR signal characteristics. Design and patients: Ten patients with NF, nine females and 1 male, with an age ranging from 13 to 58 years (mean 26.8 years) were studied. MRI findings, available in all 10 patients, were compared with the histopathology in nine patients, and an area-to-area comparative study of the whole specimen section histopathology and MRI was performed in two patients. Results: On the basis of an excisional biopsy or resection specimen, the nine lesions were classified into myxoid (n=4), cellular (n=3) and fibrous (n=2) subtypes. Four myxoid lesions with a subcutaneous location showed a homogeneous SI comparable with muscle on T1-weighted images, high SI on T2-weighted images, and had homogeneous enhancement. One cellular lesion presented with ...

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The generation of synthetic forms of cellular life requires solutions...Full Text Available

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... Accession Number : ADD421949. Title : Ultimate Compressive Strength and Nonlinear Stress-Strain Curves of Graphite/Epoxy Laminates,. ...

International Nuclear Information System (INIS)

The neutron star parameters in the model extended by the inclusion of #delta# meson and additional nonlinear vector meson interactions are studied.

International Nuclear Information System (INIS)

... parameters magnetic fields magnetic properties magnetization monocrystals

DEFF Research Database (Denmark)

The coupling between cerebral metabolic rate of oxygen (CMRO2) and blood flow (CBF) in response to visual stimulation was evaluated by means of a model of oxygen delivery. The model predicted a nonlinear relationship between stimulus-evoked changes of oxygen consumption and blood flow. The magnitude of the CMRO2/CBF ratio index (IO2) was used to indicate the degree of flow-metabolism coupling prevailing in specific areas of the brain during physiological stimulation. Therefore, the index provided a measure of the blood oxygenation level dependent (BOLD) magnetic resonance contrast. To evaluate the changes of IO2 in response to visual stimulation, the model was applied to the effect of a changing flicker rate of a visual stimulus on the magnitudes of CBF, CMRO2, and oxygen diffusion capacity, in the human brain. Positron emission tomography (PET) was used to measure the CBF and the CMRO2 in 12 healthy volunteers who viewed a cross-hair ...

International Nuclear Information System (INIS)

For a number of starless cores, self-absorbed molecular line and column density observations have implied the presence of large-amplitude oscillations. We examine the consequences of these oscillations on the evolution of the cores and the interpretation of their observations. We find that the pulsation energy helps support the cores and that the dissipation of this energy can lead toward instability and star formation. In this picture, the core lifetimes are limited by the pulsation-decay timescales, dominated by non-linear mode-mode coupling, and on the order of #approx =# few x 10"5-10"6 yr. Notably, this is similar to what is required to explain the relatively low rate of conversion of cores into stars. For cores with large-amplitude oscillations, dust continuum observations may appear asymmetric or irregular. As a consequence, some of the cores that would be classified as super-critical may be dynamically stable when oscillations are taken into account. Thus, ...

International Nuclear Information System (INIS)

Beams may be viewed as directed and focussed flow of energy and information, carried by particles and electromagnetic radiation fields (ie, photons). Often, they interact with each other (eg, in high energy colliders) or with other forms of matter (eg, in fixed targets, sychrotron radiation, neutron scattering, laser chemistry/physics, medical therapy, etc.). The whole art and science of beams revolve around the fundamental quest for, and ultimate implementation of, mechanisms of production, storage, control and observation of beams -- always directed towards studies of the basic structures and processes of the natural world and various practical applications. Tremendous progress has been made in all aspects of beam physics and technology in the last decades -- nonlinear dynamics, superconducting magnets and rf cavities, beam instrumentation and control, novel concepts and collider praradigms, to name a few. We illustrate this progress with a ...

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The optical and nonlinear optical properties of colloidal solutions of silver obtained by laser ablation in water and ethanol are studied. It is shown that freshly prepared colloids experience a full or partial sedimentation by changing their nonlinear optical properties. Aqueous colloids undergo a partial sedimentation and their nonlinear optical absorption changes to nonlinear optical transmission. The obtained results are interpreted using the Drude model for metal particles taking the particle size into account and can be explained by the sedimentation of larger silver particles accompanied by the formation of a stable colloid containing silver nanoparticles with a tentatively silver oxide shell. The characteristic size of particles forming such a stable colloid is determined and its optical nonlinearity is estimated.

UK PubMed Central (United Kingdom)

Cellular polarity is a fundamental property of every cell. Due to their extremely fast growth rate (≥1 μm/s) and their highly elongated form, filamentous fungi represent a prime example...Full Text Available

UK PubMed Central (United Kingdom)

The extensive membrane network of the endoplasmic reticulum (ER) is physically juxtaposed to and functionally entwined with essentially all other cellular compartments. Therefore, the ER must sense...Full Text Available

UK PubMed Central (United Kingdom)

Oxidative stress occurs when the level of prooxidants exceeds the level of antioxidants in cells resulting in oxidation of cellular components and consequent loss of cellular function. Oxidative...Full Text Available

UK PubMed Central (United Kingdom)

Optical coherence microscopy (OCM) is a promising technique or high resolution cellular imaging in human tissues. An OCM system for high-speed en face cellular resolution imaging...Full Text Available

UK PubMed Central (United Kingdom)

Pestiviruses are positive-strand RNA viruses closely related to human hepatitis C virus. Gene expression of these viruses occurs via translation of a polyprotein, which is further processed by cellular...Full Text Available

UK PubMed Central (United Kingdom)

Two cellular DNA regions representing common domains for proviral DNA integration ( Mlvi -1 and Mlvi -2) have been identified in Moloney murine leukemia virus-induced rat thymic lymphomas. Cellular...Full Text Available

UK PubMed Central (United Kingdom)

Diamagnetic samples placed in a strong magnetic field and a magnetic field gradient experience a magnetic force. Stable magnetic levitation occurs when the magnetic force exactly counter balances...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Science.gov (United States)

in pulse applications such as magnetic forming. ... In magnetic-forming electric circuitry, the ..... Aspects of Electrohydraulic land Magnetic Forming. ...

CERN Document Server

To understand dynamic developmental processes, living tissues must be imaged frequently and for extended periods of time. Root development is extensively studied at cellular resolution to understand basic mechanisms underlying pattern formation and maintenance in plants. Unfortunately, ensuring continuous specimen access, while preserving physiological conditions and preventing photo-damage, poses major barriers to measurements of cellular dynamics in indeterminately growing organs such as plant roots. We present a system that integrates optical sectioning through light sheet fluorescence microscopy with hydroponic culture that enables us to image at cellular resolution a vertically growing Arabidopsis root every few minutes and for several consecutive days. We describe novel automated routines to track the root tip as it grows, track cellular nuclei and identify cell divisions. We demonstrate the ...

Science.gov (United States)

Phenomena in power systems tend to exhibit higher nonlinearity, because efficient operation accompanies severer power transfer. In such cases, there might exist some limitation to the use of conventional linear control design scheme due to the nonlinearity. As for consideration to the nonlinearity, we have developed a nonlinear analysis method based on normal form theory. In this paper, we develop a new control design scheme based on the nonlinear analysis method. The developed method is effective in a case when oscillatory instability occurs. In the developed method, the parameters of control devices are adjusted so as to enlarge the stability limit against the oscillatory instability, unless each eigenvalue exceed its allowable threshold. We verify the effectiveness of the developed method in the IEEJ 10-machine System Model by applying to PSS (Power System Stabilizer). We show ...

CERN Document Server

The purpose of this paper is to present the extended definitions and characterizations of the classical notions of APN and maximum nonlinear Boolean functions to deal with the case of mappings from a finite group K to another one N with the possibility that one or both groups are non-Abelian.

UK PubMed Central (United Kingdom)

This article compared conceptual and empirical strengths of alternative methods for estimating racial disparities using non-linear models of health care access. Three methods were presented...Full Text Available

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... Abstract : Two traces in flexible cables used in the Milstar agile beam antenna system failed during acceptance testing. ...

Energy Technology Data Exchange (ETDEWEB)

The author presents his impressions of the conference - that is - major lessons as presented in the talks on nonlinearities and their role in condensed matter physics. (WRF)

Energy Technology Data Exchange (ETDEWEB)

The problem of efficient capture of nonlinear oscillations into resonance is discussed. The capture is guaranteed by passage through resonance when the system starts in equilibrium and the driving amplitude exceeds a threshold. The threshold problem is described by a universal nonlinear Schroedinger-type equation with a single parameter and cannot be analyzed by perturbation methods. A similar threshold phenomenon is a characteristic of two weakly coupled oscillators with a slow parameter if one of the oscillators starts in equilibrium, allowing efficient capture into resonance and subsequent adiabatic (autoresonant) control of strongly excited nonlinear oscillations.

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... A control design methodology enabling the adaptive neural augmentation. ... As an example, the problem of designing a neural augmentation system. ...

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Radial Halbach magnetic bearings have been investigated as part of an effort to develop increasingly

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Necessary theoretical foundation is given for the treatment of magnetic stresses applied to

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Discussion of an electrohydraulic and magnetic forming process

International Nuclear Information System (INIS)

It is shown that low-frequency elastic vibrations of near-surface planar defects cause high-frequency ultrasonic radiation in surrounding air. The frequency conversion mechanism is concerned with contact nonlinearity of the defect vibrations and provides efficient generation of air-coupled higher-order ultraharmonics, ultrasubharmonics, and combination frequencies. The nonlinear air-coupled ultrasonic emission is applied for location and high-resolution imaging of damage-induced defects in a variety of solid materials.

Energy Technology Data Exchange (ETDEWEB)

Magnetic separation of several classes of antibiotics was investigated using electrochemical magnetic seeding. Electrocoagulation with a sacrificial anode followed by addition of magnetite particles was applied for the magnetic seeding of antibiotics. With electrochemical magnetic seeding using an iron anode, tetracycline antibiotics (oxytetracycline, chlortetracycline, doxycycline and tetracycline) and cephalosporin antibiotic (cefdinir) were rapidly removed from synthetic wastewater by magnetic separation using a neodymium magnet. Iron and aluminium anodes were suitable for magnetic seeding of the antibiotics. The results indicated that the ability of antibiotics to form strong complex with iron and aluminium allowed the higher removal by magnetic separation. This method would be appropriate for rapid treatment of ...

UK PubMed Central (United Kingdom)

Despite a complex cascade of cellular events to reconstruct the damaged extracellular matrix, ligament healing results in a mechanically inferior scarred ligament. During normal healing, granulation...Full Text Available

UK PubMed Central (United Kingdom)

In an effort to develop octahedral metal complexes as chemotherapeutic and diagnostic agents targeted to DNA, it is critical to optimize the properties of their cellular uptake. Appending d-octaarginine...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundTacrolimus (FK-506) is an immunosuppressant that binds to a specific immunophilin, resulting in the suppression of the cellular immune response during transplant rejection....Full Text Available

UK PubMed Central (United Kingdom)

The steroidal regulation of vertebrate neuroanatomy and neurophysiology includes a seemingly unending list of brain areas, cellular structures and behaviors modulated by these hormones. Estrogens,...Full Text Available

UK PubMed Central (United Kingdom)

Although the initiating factor(s) is unknown, it is now accepted that pulmonary sarcoidosis develops as a result of an over-stimulated local cellular immune response. Starting as a lymphocytic alveolitis,...Full Text Available

UK PubMed Central (United Kingdom)

Aggregatibacter (Actinobacillus) actinomycetemcomitans is a facultative anaerobic gram-negative bacterium associated with severe forms of periodontitis. A leukotoxin, which belongs...Full Text Available

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AbstractWe propose a mechanism for the formation of membrane oscillations and traveling waves, which arise due to the coupling between the actin cytoskeleton and the calcium flux through...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

An nonlinear analysis of an annular beam propagating through a cylindrical waveguide in the presence of a helical wiggler and an axial guide field is presented. The analysis is based upon the ARACHNE simulation which is a non-wiggler-averaged slow-time-scale simulation code in which the electromagnetic field is represented as a superposition of the TE and TM modes in a vacuum waveguide, and the beam space-charge waves are represented as a superposition of Gould-Trivelpiece modes. The DC self-electric and self-magnetic fields are also included in the model. ARACHNE has been extensively benchmarked against experiments at MIT and NRL in the past with good agreement, but all of these experiments have dealt with solid electron beams and beam voltages in excess of 200 kV. In seeking to reduce the beam voltage requirements we now consider the effect of operation with an annular beam. One advantage to be obtained by using an annular beam is that, for a ...

International Nuclear Information System (INIS)

... magnetic susceptibility magnetization monocrystals neutron diffraction

CERN Document Server

Checks are performed on the alignment of the magnets in the LHC tunnel. It is vital that each magnet is placed exactly where it has been designed so that the path of the beam is precisely controlled.

British Library Electronic Table of Contents (United Kingdom)

A novel class of pyrrolidinyl-acetyleneic thieno[3,2-d]pyrimidines has been identified which potently inhibit the EGFR and ErbB-2 receptor tyrosine kinases. Synthetic modifications of the pyrrolidine carbamate moiety result in a range of effects on enzyme and cellular potency. In addition, the impact of the absolute stereochemical configuration on cellular potency and oral mouse pharmacokinetics is described.

Energy Technology Data Exchange (ETDEWEB)

Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.

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Rare Earth Cobalt (REC) permanent magnets have unique properties that permit solutions to some optical tasks that cannot be accomplished with conventional magnets. A review of design and of performance characteristics of these magnets includes an analytical description of the three dimensional fringe fields of REC quadrupoles.

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Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. The authors have investigated whether common cellular DNA domains might be rearranged, possibly by HBV integration, in human primary liver tumors. Unique cellular DNA sequences adjacent to an HBV integration site were isolated from a patient with hepatitis B surface antigen-positive hepatocellular carcinoma. These probes detected rearrangement of this cellular region of chromosomal DNA in 3 of 50 additional primary liver tumors studied. Of these three tumor samples, two contained HBV DNA, without an apparent link between the viral DNA and the rearranged allele; HBV DNA sequences were not detected in the third tumor sample. By use of a panel of somatic cell hybrids, these unique cellular DNA sequences were shown to be located on chromosome 4. Therefore, this region of chromosomal DNA might be ...

Science.gov (United States)

Electrospinning has gained much attention in the past decade as an effective means of generating nano- to micro-scale polymer fibers that resemble native extracellular matrix. High porosity, pore interconnectivity, and large surface area to volume ratio of electrospun scaffolds make them highly conducive to cellular adhesion and growth. However, inherently small pores of electrospun scaffolds do not promote adequate cellular infiltration and tissue ingrowth. Cellular infiltration into the scaffold is essential for a range of tissue engineering applications and is particularly important in skin and musculoskeletal engineering. Pore size, porosity, and pore interconnectivity dictate the extent of cellular infiltration and tissue ingrowth into the scaffold; influence a range of cellular processes; and are crucial for diffusion of nutrients, metabolites, and waste products. A number of ...

CERN Document Server

We consider a class of nonlinear Schrodinger / Gross-Pitaevskii (NLS/GP) equations with periodic potentials, having an even symmetry. We construct "solitons", centered about any point of symmetry of the potential. For focusing (attractive) nonlinearities, these solutions bifurcate from the zero state at the lowest band edge frequency, into the semi-infinite spectral gap. Our results extend to bifurcations into finite spectral gaps, for focusing or defocusing (repulsive) nonlinearities under more restrictive hypotheses. Soliton nonlinear bound states with frequencies near a band edge are well-approximated by a slowly decaying solution of a homogenized NLS/GP equation, with constant homogenized effective mass tensor and effective nonlinear coupling coefficient, modulated by a Bloch state. For the critical NLS equation with a periodic potential, e.g. the cubic two dimensional NLS/GP ...

International Nuclear Information System (INIS)

... radiations isotopes magnetic moments nuclear cascades nuclear properties

Science.gov (United States)

... in the design of such devices as fusion reactors, magnetohydrodynamic generators, magnetically levitated vehicles, magnetic forming devices, and ...

Science.gov (United States)

Decoupling force exerted by magnetic forming Be coil assembly on metallic plate during forming

Science.gov (United States)

A previous paper introduced the use of wave digital filters as a basic building block for power system simulation, particularly suitable for real-time applications. This paper stresses the simulation of non-linear and switching elements, emphasizing the advantages of the wave filters implementation. The digital structure is maintained even when non-linear components change their characteristics or power electronic devices switch their states. As a very important by-product, the suppression of numerical oscillations related to the trapezoidal rule is achieved in a rather simple way, with no effects on simulation results.

Energy Technology Data Exchange (ETDEWEB)

This investigation concerns the nonlinear dynamics of heat transfer from a surface using an upstream eddy promoter. A numerical model is developed for the coupled fluid flow and heat transfer process based on a modified MacCormack scheme. Numerical simulations are carried out to determine the response and heat transfer enhancement due to the promoter. The average heat transfer from a cavity floor is seen to be increased by a factor of approximately five over the unpromoted'' flow. Another interesting feature of the study is the nonlinear viscous flow dynamics from the cylinder-wall interaction which differ significantly from the familiar cylinder-free stream patterns.

CERN Document Server

Using an exactly soluble one-dimensional atomic model we explore the idea that the recently observed high-order nonlinearity in optical filaments is due to virtual transitions involving the continuum states. We show that the model's behavior is qualitatively comparable with the experimentally observed cross-over from self-focusing to de-focusing at high intensities, and only occurs at intensities which result in significant ionization. Based on these observations, we conjecture that this continuum electron nonlinear refraction exhibits strong memory effects, and most importantly, the change of its sign is effectively masked by the de-focusing due to free electrons.

CERN Document Server

A discrete time control algorithm using the damped least squares is introduced for acceleration and energy exchange controls in nonlinear vibrating systems. It is shown that the damping constant of least squares and sampling time step of the controller must be inversely related to insure that vanishing the time step has little effect on the results. The algorithm is illustrated on two linearly coupled Duffing oscillators near the 1:1 internal resonance. In particular, it is shown that varying the dissipation ratio of one of the two oscillators can significantly suppress the nonlinear beat phenomenon.

International Nuclear Information System (INIS)

In order to examine the state of technology of all areas of magnetic suspension and to review related recent developments in sensors and controls approaches, superconducting magnet technology, and design/implementation practices, a symposium was held. The proceedings are presented. The sessions covered the areas of bearings, sensors and controls, microgravity and vibration isolation, superconductivity, manufacturing applications, wind tunnel magnetic suspension systems, magnetically levitated trains (MAGLEV), space applications, and large gap magnetic suspension systems.

Science.gov (United States)

... electronic feedback system' connected to a Q switch ... The use of acousto-optic (AO) beam steering devices for BMDO (SDI) applications is very ...

Energy Technology Data Exchange (ETDEWEB)

In this paper, research on pass schedule of tandem cold mill (TCM) is carried out. According to load (reduction, rolling force, motor power) balance, non-linear equations set with variables of inter-stand thickness is constructed. The pass schedule optimization is carried out by solving the non-linear equations set. As the traditional method, the Newton-Raphson method is used for solving the non-linear equations set. In this paper a new simple method is brought up. On basis of the monotone relations between thickness and load, the inter-stands thickness is adjusted dynamically. The solution of non-linear equations set can be converged by iterative calculation. This method can avoid the derivative calculation used by traditional method. So, this method is simple and calculation speed is high. It is suitable for on-line control. (author)

International Nuclear Information System (INIS)

A quantum mechanical analysis of the guided light in integrated photonics waveguides is presented. The analysis is made starting from one-dimensional (1D) guided vector modes by taking into account the modal orthonormalization property on a cross section of an optical waveguide, the vector structure of the guided optical modes and the reversal-time symmetry in order to quantize the 1D vector modes and to derive the quantum momentum operator and the Heisenberg equations. The results provide a quantum-consistent formulation of the linear and nonlinear quantum light propagations as a function of forward and backward creation and annihilation operators in integrated photonics. As an illustration, an application to an integrated nonlinear directional coupler is given, that is, both the nonlinear momentum and the Heisenberg equations of the nonlinear coupler are derived.

British Library Electronic Table of Contents (United Kingdom)

Noninvasive prediction of vertebral body strength under compressive loading condition is a valuable tool for the assessment of clinical fractures. This paper presents an effective specimen-specific approach for noninvasive prediction of human vertebral strength using a nonlinear finite element (FE) model and an image based parameter based on the quantitative computed tomography (QCT). Nine thoracolumbar vertebrae excised from three cadavers with an average age of 42 years old were used as the samples. The samples were scanned using the QCT. Then, a segmentation technique was performed on each QCT sectional image. The segmented images were then converted into three-dimensional FE models for linear and nonlinear analyses. A new material model was implemented in our nonlinear model being more...

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English 6 Aug 2010 p. 492-493 United States Korniyenko, N. Ye. Kiev Taras

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Frm Apwd Dcn,-fl r%,'I-UMENTATION PAGE OMI Mo 04ve On isestVIaVO= to aere hourer p ponse ncudhngthe time for reviewing instrutions. ...

CERN Document Server

In a recent paper [4], Duarte and Jutten investigated the Blind Source Separation (BSS) problem, for the nonlinear mixing model that they introduced in that paper. They proposed to solve this problem by using information-theoretic tools, more precisely by minimizing the mutual information (MI) of the outputs of the separating structure. When applying the MI approach to BSS problems, one usually determines the analytical expressions of the derivatives of the MI with respect to the parameters of the considered separating model. In the literature, these calculations were mainly reported for linear mixtures up to now. They are more complex for nonlinear mixtures, due to dependencies between the considered quantities. Moreover, the notations commonly employed by the BSS community in such calculations may become misleading when using them for nonlinear mixtures, due to the above-mentioned dependencies. We claim that the ...

Science.gov (United States)

and shock induced flow separation may significantly affect the flutter ...... Aerodynamic and Aeroelastic Simulation, AGARD Report 822, 10-1 10-20. ...

Science.gov (United States)

The infection of cultured human cells with baboon endogenous virus (BEV) frequently leads to an association of viral DNA with a specific genetic locus (termed BEVI, for baboon endogenous virus infection) on chromosome 6. Restriction endonuclease digestion of DNA from BEV-infected human cells and their derived somatic cell clones frequently revealed a common cellular DNA sequence in the proximity of one of the junctions between cellular DNA and the integrated virus. We propose that a short cellular DNA sequence, repeated on chromosome 6 and separated by unique DNA sequences, presents a high-affinity target for the integration of BEV in human cells. PMID:6401843

International Nuclear Information System (INIS)

The clinical use of "1"8F-fluorodeoxyglucose (FDG) positron emission tomography in monitoring anticancer treatment is expanding. At the same time a number of radiotracers aiming to image different aspects of tumour biology such as proliferation and apoptosis are being developed. However, the factors determining changes of radiotracer uptake parameters in response to treatment are not well understood. In many cases, cellularity may be the primary determinant of changes of FDG uptake and may confound the interpretation of metabolic changes. Early imaging assessments have in some cases showed transient increases of uptake parameters, commonly termed 'flares', which are likely to be unaffected by cellularity and directly reflect pharmacodynamics at a cellular level. In this review a number of settings where molecular imaging 'flares' have been described are discussed. Such changes may often be clinically informative and warrant ...

International Nuclear Information System (INIS)

To investigate the magnetic fluctuations and for further transport study, the poloidal and radial magnetic field measurement is conducted on the Sino United Spherical Tokamak (SUNIST). Auto-power spectral density indicates that the magnetic fluctuation energy mainly concentrates in the frequency region lower than 10 kHz. The magnetic field oscillations, which are characterized by harmonic frequencies of 40 kHz, are observed in the scrape-off layer; by contrast, in the plasma core, the magnetic fluctuations are of Gaussian type. The time-frequency profiles show that the poloidal magnetic fluctuations are temporally intermittent. The autocorrelation calculation indicates that the fluctuations in decorrelation time vary between the core and the edge. (authors)

CERN Document Server

A quantitative description is presented of the non-linear current-voltage response in superconducting niobium cavities for accelerator application. It is based on a fit for a large sample of data from cavity tests of different kind. Trial functions for the surface resistance describing this non-linear relation are established by a least square data fit. Those trial functions yielding the best fit are quantitatively explained by basic physics.

International Nuclear Information System (INIS)

Four inorganic hydrogen-bonded crystals with second-order nonlinear properties have been discovered: K_4LiH_3(SO_4)_4, Na_2SeO_4#centre dot#H_2SeO_3#centre dot#H_2O, Cs_1_,_5Li_1_,_5H(SO_4)_2 and NH_4HSeO_4. (author)

International Nuclear Information System (INIS)

Analytical expressions for thermoluminescence (TL) dating based on the modified Zimmerman model were derived. The non-linear behaviour of TL sensitivity is reexamined and is found to be due to electron capturing competitions in both test-dose excitation and the readout stages. A curve fitting method is proposed to determine the paleodose for the additive dose dating method. The multiple activation technique is also investigated, from which the paleodose should be regarded as an upper limit.

Energy Technology Data Exchange (ETDEWEB)

The hierarchy of integrable nonlinear equations associated with the quadratic bundle is considered. The expressions for the solution of linearization of these equations and their conservation law in the terms of solutions of corresponding Lax pairs are found. It is shown for the first member of the hierarchy that the conservation law is connected with the solution of linearized equation due to the Noether's theorem. The local hierarchy and three nonlocal ones of the infinitesimal symmetries and conservation laws explicitly expressed through the variables of the nonlinear equations are derived. (author)

International Nuclear Information System (INIS)

We have used an extension of the BFFT formalism presented by Banerjee et al. in order to gauge the nonlinear sigma model by means of a non-Abelian algebra. we have considered the supersymmetric and the usual cases. We have shown that the supersymmetric case is only consistently transformed in a first-class theory by means of a non-Abelian algebra. The usual BFFT treatment leads to a nonlocal theory. (author)

CERN Document Server

We consider a nonlinear reaction-diffusion equation settled on the whole euclidean space. We prove the well-posedness of the corresponding Cauchy problem in a general functional setting, namely, when the initial datum is uniformly locally bounded in L^2. Then we adapt the short trajectory method to establish the existence of the global attractor and, if the space dimension is at most 3, we also find an upper bound of its Kolmogorov's entropy.

Energy Technology Data Exchange (ETDEWEB)

This is a numerical verification of two groups of pipe whip tests sponsored or cosponsored by EPRI. Experimental data of the two pipe whip tests, one by Tennessee Valley Authority (TVA) and by FRAMATOME/CEA, were provided by EPRI. A nonlinear finite element code, ABAQUS-EPGEN, developed under partial sponsorship by EPRI was used for modeling the pipe whip tests. Beam elements together with an equivalent nonlinear spring element or a partial shell mesh were used to model pipes and elbow in the pipe whip tests. Material nonlinearity due to plasticity, strain rate effects, and temperature, as well as geometric nonlinearity due to large rotation and boundary conditions were included in the study. Effects of strain rate and modeling techniques were assessed. Results by current industry approach were also included as a reference solution. This report can be used as a guideline for numerical simulation of pipe ...

International Nuclear Information System (INIS)

In the case wherein nonlinear seismic response analyses are carried out, the response values vary due to the variations in materials and modeling. In this paper, nonlinear analyses of several random variables are carried out using: i. a conventional method; ii. a two-point estimation method (i. and ii. are simplified methods); and iii. Monte Carlo simulation (detailed method) to examine the variability of the response in the excessive nonlinear range for seismic responses of shear walls. The analyses are performed to a PWR-3 loop type reactor building which is one of the most typical reactor buildings in Japan. The variations are considered in specified compressive strength of concrete, concrete damping factor, shear wave velocity of soil and shapes of shear stress-strain relation curves of shear walls. As the results by the two simplified methods closely matched the Monte Carlo simulation results, the appropriateness for ...

Energy Technology Data Exchange (ETDEWEB)

Potassium clusters arrayed in zeolite A are known to show ferromagnetic properties at low temperature. The origin of the spontaneous magnetization has been explained by a model of spin-canting in an antiferromagnetically ordered state. The direct information for the magnetic structure, however, has not been obtained so far. In the present work, we measure the neutron powder diffraction by using pulsed neutron source at KEK-KENS below and above the Curie temperature. No significant temperature-dependence was, however, obtained within the statistical errors, namely, magnetic scattering could not be detected separately. We also estimate the intensity of magnetic scattering by assuming some possible magnetic structures with considering the magnetic form factor of the cluster wave function. The intensity of magnetic scattering is estimated to be ...

International Nuclear Information System (INIS)

Scanning ion microscopy with polarization analysis (SIMPA) is used to study the spin-resolved surface magnetic structure of nano-sized magnetic systems. SIMPA is utilized for in situ topographic and spin-resolved magnetic domain imaging as well as for focused ion beam (FIB) etching of desired structures in magnetic or non-magnetic systems. Ultra-thin Co films are deposited on surfaces of Si(1 0 0) substrates, and ultra-thin, tri-layered, bct Fe(1 0 0)/Mn/bct Fe(1 0 0) wedged magnetic structures are deposited on fcc Pd(1 0 0) substrates. SIMPA experiments clearly show that ion-induced electrons emitted from magnetic surfaces exhibit non-zero electron spin polarization (ESP), whereas electrons emitted from non-magnetic surfaces such as Si and Pd exhibit zero ESP, which can be used to calibrate sputtering rates in situ. We ...

Energy Technology Data Exchange (ETDEWEB)

A model is available in predicting flocculation frequencies between particles of various properties under the influence of a magnetic field. This model provides a basic understanding of fundamental phenomena, such as particle-particle and particle-collector interactions, occurring in HGMF (high gradient magnetic field), and will be extended to describe experimental data of particle flocculation and filtration and predict the performance of high- gradient magnetic filters. It is also expected that this model will eventually lead to a tool for design and optimization of magnetic filters for environmental, metallurgical, biochemical, and other applications.

UK PubMed Central (United Kingdom)

Global acetylation of histone H4 is a mark of gene transcriptional activation. The c-Myc transcription factor binds to specific DNA sites in cellular chromatin and induces the acetylation of...Full Text Available

UK PubMed Central (United Kingdom)

During germination and early growth of castor bean (Ricinus communis), all cellular constituents of the endosperm are eventually transferred to the growing embryo. The present results...Full Text Available

UK PubMed Central (United Kingdom)

p53 is one of the most mutated tumor suppressors in human cancers and as such has been intensively studied for a long time. p53 is a major orchestrator of the cellular response to a broad array...Full Text Available

UK PubMed Central (United Kingdom)

The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover,...Full Text Available

UK PubMed Central (United Kingdom)

The RNA-binding protein Hfq is recognized as an important regulatory factor in a variety of cellular processes, including stress resistance and pathogenesis. Hfq has been shown in several bacteria to...Full Text Available

UK PubMed Central (United Kingdom)

Interactions between presynaptic and postsynaptic cellular adhesion molecules (CAMs) drive synapse maturation during development. These trans-synaptic interactions are regulated by alternative splicing...Full Text Available

UK PubMed Central (United Kingdom)

Somatic embryogenesis (SE) is the developmental restructuring of somatic cells towards the embryogenic pathway and forms the basis of cellular totipotency in angiosperms. With the availability of full-length...Full Text Available

UK PubMed Central (United Kingdom)

In this work, we explore the potential of the metalloendopeptidase Lys-N for MALDI-MS/MS proteomics applications. Initially we digested a HEK293 cellular lysate with Lys-N and, for comparison, in parallel...Full Text Available

UK PubMed Central (United Kingdom)

Taste cells use multiple signaling mechanisms to generate appropriate cellular responses to discrete taste stimuli. Some taste stimuli activate G protein coupled receptors (GPCRs) that cause calcium...Full Text Available

UK PubMed Central (United Kingdom)

AbstractStudies performed to identify early events of ovarian cancer and to establish molecular markers to support early detection and development of chemopreventive regimens have been...Full Text Available

UK PubMed Central (United Kingdom)

A number of studies have indicated that plasma membrane calcium ATPases (PMCAs) are expressed in the brain and spinal cord and could play important roles not only in the maintenance of cellular calcium...Full Text Available

UK PubMed Central (United Kingdom)

Although cellular immunity has a crucial role during cryptococcosis, several in vitro studies have pointed out the importance of IgG anti-Cryptococcus neoformans antibodies and complement components...Full Text Available

UK PubMed Central (United Kingdom)

Totipotent stem cells have the potential to differentiate into every cell type. Renewal of totipotent stem cells in the germline and cellular differentiation during early embryogenesis rely upon posttranscriptional...Full Text Available

UK PubMed Central (United Kingdom)

The ubiquitin–proteasome pathway is the principal system for extralysosomal protein degradation in eukaryotic cells, and is essential for the regulation and maintenance of basic cellular processes,...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVENicotinamide adenine dinucleotides (NAD⁺ and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD⁺-to-NADH ratio is implicated...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundStem cell characteristics are an important feature of human cancer cells and play a major role in the therapy resistance of tumours. Strategies to target cancer stem cells...Full Text Available

UK PubMed Central (United Kingdom)

The integration sites for viral DNA in cells infected with Moloney murine leukemia virus (M-MuLV) were studied by restriction endonuclease cleavage of cellular DNA followed by electrophoresis in agarose...Full Text Available

UK PubMed Central (United Kingdom)

Cancer immunotherapies can be guided by cellular imaging techniques, which can identify the presence or absence of immune-cell accumulation in the tumor tissue in-vivo and in real time. This...Full Text Available

UK PubMed Central (United Kingdom)

Choline (Cho)-containing phospholipids are the most abundant phospholipids in cellular membranes and play fundamental structural as well as regulatory roles in cell metabolism and signaling. Although...Full Text Available

UK PubMed Central (United Kingdom)

Using the photopigment melanopsin, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light to drive circadian clock resetting and pupillary constriction. We now...Full Text Available

UK PubMed Central (United Kingdom)

IntroductionNormal and neoplastic breast tissues are comprised of heterogeneous populations of epithelial cells exhibiting various degrees of maturation and differentiation. While...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundLipocalin 2 (Lcn2) is a bacteriostatic factor that may also modulate cellular function, however, little is known concerning the expression or role of Lcn2 in CNS inflammation....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe Gene Ontology (GO) is a well known controlled vocabulary describing the biological process, molecular function and cellular...Full Text Available

UK PubMed Central (United Kingdom)

The human immunodeficiency virus type 1 (HIV-1) packages its genomic RNA as a dimer of homologous RNA molecules that has to be selected among a multitude of cellular and viral RNAs. Interestingly, spliced...Full Text Available

UK PubMed Central (United Kingdom)

The intramembrane aspartyl protease γ-secretase plays a fundamental role in several signaling pathways involved in cellular differentiation and has been linked with a variety of human diseases,...Full Text Available

UK PubMed Central (United Kingdom)

In addition to regulating acid secretion, the gastric antral hormone gastrin regulates several important cellular processes in the gastric epithelium including proliferation, apoptosis, migration, invasion,...Full Text Available

UK PubMed Central (United Kingdom)

Telomerase, a ribonucleoprotein enzyme that maintains telomere length, is crucial for cellular immortalization and cancer progression. Telomerase activity is attributed primarily to the expression of...Full Text Available

UK PubMed Central (United Kingdom)

Cellular hypertrophy is regulated by coordinated pro- and antigrowth machineries. Foxo transcription factors initiate an atrophy-related gene program to counter hypertrophic growth. This study was designed...Full Text Available

UK PubMed Central (United Kingdom)

Accumulation of molecular damage and increased molecular heterogeneity are hallmarks of cellular aging. Mild stress-induced hormesis can be an effective way for reducing the accumulation of molecular...Full Text Available

UK PubMed Central (United Kingdom)

Neurofibromatosis type 1 (NF1) results from mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. NF1 patients display diverse clinical manifestations,...Full Text Available

CERN Document Server

Heterogeneous base stations (e.g. picocells, microcells, femtocells and distributed antennas) will become increasingly essential for cellular network capacity and coverage. Up until now, little basic research has been done on the fundamentals of managing so much infrastructure -- much of it unplanned -- together with the carefully planned macro-cellular network. Inter-cell coordination is in principle an effective way of ensuring different infrastructure components behave in a way that increases, rather than decreases, the key quality of service (QoS) metrics. The success of such coordination depends heavily on how the overhead is shared, and the rate and delay of the overhead sharing. We develop a novel framework to quantify overhead signaling for inter-cell coordination, which is usually ignored in traditional 1-tier networks, and assumes even more importance in multi-tier heterogeneous cellular networks (HCNs). We derive ...

UK PubMed Central (United Kingdom)

AIM: To identify a method for efficient large-scale purification of functional hepatitis B virus polymerase (HBV-Pol) without addition of cellular factors.METHODS: Full-length HBV-Pol (843 amino...Full Text Available

UK PubMed Central (United Kingdom)

Lumbricus terrestris (Annelid, Oligocheta) is capable of cellular- and humoral-specific reactions against natural antigens. Is this earthworm able to elaborate a response of antibody type against a...Full Text Available

UK PubMed Central (United Kingdom)

Zygotes of fucoid algae have long been studied as a paradigm for cell polarity. Polarity is established early in the first cell cycle and is then expressed as localized growth and invariant cell division....Full Text Available

UK PubMed Central (United Kingdom)

The programming of cellular networks to achieve new biological functions depends on the development of genetic tools that link the presence of a molecular signal to gene-regulatory activity. Recently,...Full Text Available

UK PubMed Central (United Kingdom)

Mitogen Activated Protein Kinases (MAPKs) are a class of serine/threonine kinases that regulate a number of different cellular activities including cell proliferation, differentiation, survival and...Full Text Available

UK PubMed Central (United Kingdom)

One of the most pervasive ideas regarding the causes of aging is that longevity is constrained in large measure by damage to macromolecules. An increasing body of cellular and molecular data, generated...Full Text Available

UK PubMed Central (United Kingdom)

The p21-activated kinases (PAKs), immediate downstream effectors of the small G-proteins of the Rac/cdc42 family, are critical mediators of signaling pathways regulating cellular behaviors and...Full Text Available

UK PubMed Central (United Kingdom)

Reversible protein glutathionylation plays a key role in cellular regulation and cell signaling and protects protein thiols from hyperoxidation. Sulfiredoxin (Srx), an enzyme that catalyzes the reduction...Full Text Available

UK PubMed Central (United Kingdom)

Background. It is currently recommended that diet of pregnant mothers contain 200–300 mg DHA/day. Aim. To determine whether DHA supplementation...Full Text Available

UK PubMed Central (United Kingdom)

The ability to adapt and respond to nutrients is an ancient cellular function, conserved from unicellular to the most complex multicellular organisms, including mammals. Mammals adapt to changes...Full Text Available

UK PubMed Central (United Kingdom)

Phosphorus is an essential mineral that maintains cellular energy and mineralizes the skeleton. Because complex actions of ion transporters and regulatory hormones regulate serum phosphorus concentrations,...Full Text Available

UK PubMed Central (United Kingdom)

The cellular receptor for murine coronavirus mouse hepatitis virus (MHV)-A59 is a member of the carcinoembryonic antigen (CEA) family of glycoproteins in the immunoglobulin superfamily. We isolated...Full Text Available

UK PubMed Central (United Kingdom)

A compensatory response, viz. in vivo recovery from radiation damage to mitochondria, occurs in preclimacteric pear fruits (Pyrus communis L.) treated with ionizing...Full Text Available

UK PubMed Central (United Kingdom)

Species differences in lifespan have been attributed to cellular survival during various stressors, designated here as ‘cell resilience’. In primary fibroblast cultures, cell...Full Text Available

UK PubMed Central (United Kingdom)

SummarySpatial control of gene expression, at the level of both transcription and translation, is critical for cellular differentiation [1-Full Text Available

UK PubMed Central (United Kingdom)

Motor function requires that motor axons extend from the spinal cord at regular intervals and that they are myelinated by Schwann cells. Little attention has been given to another cellular structure,...Full Text Available

UK PubMed Central (United Kingdom)

CSV consists of a very complex of molecules and demonstrates significant cellular activities capable of stimulating immune functions in vivo. The purpose of this study was to analyze the effects of...Full Text Available

UK PubMed Central (United Kingdom)

Polyclonal antibodies were raised in rabbits by immunization with free peptides corresponding to positions 197-222 of the human beta 1-adrenergic receptor (beta 1 peptide) and the corresponding sequence...Full Text Available

UK PubMed Central (United Kingdom)

Transgenic mouse models have contributed considerably to our understanding of the cellular and molecular mechanisms by which androgens control spermatogenesis. Cell-selective ablation of the androgen...Full Text Available

UK PubMed Central (United Kingdom)

Atherosclerosis is an inflammatory process leading to enhanced cellular proliferation, apoptosis, and vasa vasorum (VV) neovascularization. While both diabetes mellitus (DM) and hypercholesterolemia...Full Text Available

UK PubMed Central (United Kingdom)

The endoplasmic reticulum (ER) is an essential cellular compartment responsible for Ca²⁺ sequestration, signaling, protein translation, folding as well as transport. Several acute...Full Text Available

UK PubMed Central (United Kingdom)

Abs facilitate humoral immunity via the classical mechanisms of opsonization, complement activation, Ab-dependent cellular cytotoxicity, and toxin/viral neutralization. There is also evidence that some...Full Text Available

UK PubMed Central (United Kingdom)

Gamma interferon (IFN-γ) and the cellular responses induced by it are essential for controlling mycobacterial infections. Most patients bearing an IFN-γ receptor ligand-binding chain...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The effect of high-energy-density laser surface melting on the morphology and properties of a cast Ni-based superalloy containing 33 wt percent Mo and 17 wt percent W is investigated experimentally. Significant improvements in the hardness and the wear resistance in both dry and acid environments are atttributed to the elimination of segregation in the laser-treated zone, where solid solubility increases, crystalline structure becomes finer, and the fine dendritic, cellular dendritic, cellular, and plane-front solidification structures are evenly distributed.

Scientific Electronic Library Online (English)

Abstract in english We present a detailed derivation of the effective dielectric constant to be used in the dispersion relation for electrostatic waves in the case of a plasma immersed in a inhomogeneous magnetic field, with inhomogeneity perpendicular to the direction of the magnetic field.

Energy Technology Data Exchange (ETDEWEB)

An analytic model of magnetic torques applied to an accreting neutron star is employed to evaluate the magnetic dipole moments of x-ray pulsars. A new type of close binary system containing a neutron star is suggested.

Science.gov (United States)

The past decade has seen the development of eddy current probes for inspection of the mildly ferro-magnetic alloy Monel 400. Due to the rapid advances in permanent magnet technology similar probes have been upgraded to magnetically saturate, and hence ins...

International Nuclear Information System (INIS)

Parameters of permanent magnets result from the combination of intrinsic properties such as saturation magnetization, magnetic exchange, and magnetocrystalline energy, as well as microstructural parameters such as phase structure, grain size, and orientation. Reduction of grain size into nanocrystalline regime (#approx# 50 nm) leads to the enhanced remanence which derives from ferromagnetic exchange coupling between highly refined grains. In this study the fundamental phenomena, quantities, and structure parameters, which define nanophase permanent magnets are presented and discussed. The theoretical considerations are confronted with experimental data for nanocrystalline Sm-Fe-N type permanent magnets. (author)

UK PubMed Central (United Kingdom)

OBJECTIVE--The study was performed to examine the influence of the exposure to magnetic fields in the potrooms of an electrolysis plant on the occurrence of musculoskeletal symptoms among the employees....Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The Muon Ionization Cooling Experiment (MICE) focusing solenoid magnets focus the muon beam within the MICE cooling channel on a liquid or solid absorber that is within the warm bore of solenoid. The focusing magnet has a warm bore of 470 mm. his magnet consists of two coils 210-mm long that is separated by an aluminum mandrel that is 200 mm long. Each of the coils has its own leads. The coils may be operated in either the non-flip mode (solenoid mode with both coils at the same polarity) or the lip mode (quadrupole focusing mode where both coils are at opposite polarity). This report describes the focusing solenoid magnet design that will be built by the vendor. The progress on the construction of the first of the focusing magnets will also be discussed in this report. Ultimately three of these magnets will be built. These magnets will be ...

Science.gov (United States)

... 31. New electric forming methods offer potentials for light metals; magnetic forming and plasma forming. ... 3, 25 Magnetic Forming ..... ...

International Nuclear Information System (INIS)

Highly ordered arrays of Ni nanoholes and Fe20Ni80 antidots have been prepared, respectively, by replica/antireplica processing and sputtering techniques using nanoporous alumina membranes as templates. Geometrical characteristics as nanohole/antidot diameter, interpore distance and the overall hexagonal symmetry of arrays are controlled through the original templates. Experimental data on their hysteresis and magnetic domain structure have been taken by vibrating sample magnetometry and magnetic force microscopy, respectively. An analysis of the magnetization process, resulting magnetic anisotropy and magnetic domain structure is summarized considering the influence of those geometry aspects. In particular, the hexagonal symmetry and the density of nanohole/antidots determine the overall magnetic behavior, which is of interest in future high-density ...

Science.gov (United States)

... M(TH) in applied magnetic fields up to ± 7 T and for temperatures ranging from 2 to 300 K. The superparamagnetic (SPM) behavior of these metallic ...

International Science & Technology Center (ISTC)

Development of Portable Normobaric Hypoxia and Pulsed Magnetic Field Firmware System for Enhancement of Radio- and Non-specific Resistance in Workers of Environmentally Hazardous Industries

International Nuclear Information System (INIS)

... dipole moments magnetic fields monocrystals neutron diffraction order-disorder

Science.gov (United States)

With the increased costs of maintaining boilers and chillers entrepreneurs around the country have offered magnetic and similar devices to facilities as viable alternatives to their maintenance program. This report gives a brief history of some of the pre...

Science.gov (United States)

Magnetic coil pressure wave generation for magnetic forming

Energy Technology Data Exchange (ETDEWEB)

From optical point of view and due to the magnetic interaction of the cold neutrons with the unpaired electron shell, magnetic materials hae a neutron spin-dependent refractive index n[sup +] [spin up] and n[sup -] [spin down]. Magnetic media such as Fe, Co and Ni react like birefringent uniaxial crystals in ordinary optica. n[sup +] and n[sup -] are the equivalent of the ordinary and extraordinary refractive indices. The specular reflection of spin polarized neutrons which is due to the discontinuity of the magnetic induction at the surface of the ferromagnet is a sensitive probe of surface and interface magnetism. We shall first give the background of the art of polarized neutron optics. Secondly, some recent examples from surface and interface magnetism will be given to illustrate the power of this technique such as the magnetic coupling ...

Science.gov (United States)

magnet research at several national laboratories through its Advanced Accelerator Technology Program. The HEP Conductor Development Program, a collaboration among national...

Energy Technology Data Exchange (ETDEWEB)

In this effort, the nonlinear responses and stability of a spindle system supported by ball bearings are presented. The dynamics of this system is described by a set of second order differential equations with a nonlinear piecewise smooth force. The Floquet theory is applied to investigate the stability of the periodic solution. Due to the loss of contact between the raceways and balls in the ball bearing, the bending of the frequency response curves switch to the left at the weak resonance region, which is similar to the frequency response curves of a system with a soft spring. With the decrease of the bearing clearance, the bending of the frequency response curves switch to the right, which is similar to the frequency response curves of a system with a hard spring. Increase of the frequency ratio, the bending of frequency response curves transforms from left to right. The route to chaos through a period doubling process is also observed in ...

British Library Electronic Table of Contents (United Kingdom)

In vibration control field, magneto-rheological (MR) fluid dampers are semi-active control devices that have recently begun to receive more attention. This paper presents a nonlinear black-box model (BBM) and an inverse black-box model (IBBM) for the identification of a MR fluid damper and their application to design a novel force-sensorless control method for any damping system using that damper. The nonlinear model named 'black-box' is a simple direct modeling method which was designed based on fuzzy-neural technique. Characteristics of the damper in study are directly estimated through a fuzzy mapping system. In order to improve the model accuracy, neural network technique including back-propagation and gradient descent method were used to train the fuzzy parameters to minimize the mode...

International Nuclear Information System (INIS)

Linear and nonlinear state feedback controllers are proposed to control the bifurcation of a phenomenon in power system, this phenomenon of electro-mechanical interaction between the series resonant circuits and torsional mechanical frequencies of the turbine-generator sections, which known as subsynchronous resonance (SSR). The first system of the IEEE second benchmark model is considered. The dynamics of the two axes damper windings, automatic voltage regulator and power system stabilizer are included. The linear controller gives better initial disturbance response than that of the nonlinear, but in a small narrow region of compensation factors. The nonlinear controller not only can be easily implemented, but also it stabilizes the operating point for all values of the bifurcation parameter.

Energy Technology Data Exchange (ETDEWEB)

The solution of the governing steady transport equations for momentum, heat and mass transfer in flowing fluids can be very difficult. These difficulties arise from the nonlinear, coupled, nonsymmetric nature of the system of algebraic equations that results from spatial discretization of the PDEs. In this manuscript the authors focus on evaluating a proposed nonlinear solution method based on an inexact Newton method with backtracking. In this context they use a particular spatial discretization based on a pressure stabilized Petrov-Galerkin finite element formulation of the low Mach number Navier-Stokes equations with heat and mass transport. The discussion considers computational efficiency, robustness and some implementation issues related to the proposed nonlinear solution scheme. Computational results are presented for several challenging CFD benchmark problems as well as two large scale 3D flow simulations.

International Nuclear Information System (INIS)

Thienyl oxazoles and thienyl isoxazoles, are composite molecules having two subsystems thiophene and oxazole molecules connected together by a single bond that they have 13 isomers. They are potential candidates for many kinds of applications such as OLED and nonlinear optical materials. Initially equilibrium geometries of title compounds have been obtained without any restriction using density functional theory with 6-311++g(2d,p) basis set. We obtained structural parameters, dipole moment and electronic energy. At the second stage, we have calculated some electronic and nonlinear optical properties such as HOMO and LUMO energies, polarizability, anisotropic polarizability and hyper polarizability using same level of theory.

Energy Technology Data Exchange (ETDEWEB)

A study on development of magnetic drive packless valves for commercial purpose showed the results as follows; 1. Study on the radial rays effecting to the permanent magnets -Measurement of the strength of Nd-magnets according to irradiation of radial rays. 2. Effects of temperature on the magnetic driving device -Temperature dependency of the Nd-casting magnets. -Effects of temperature on the heat releasing fins of high-temperature valve. 3. Optimization of torque -Arranging method of permanent magnets -Measuring method and results of torque. 4. Design, manufacture and test for the pressure-resisting structure of magnetic power transmitting device -Calculation and design for the flat circular plates under pressure of the magnetic power transmitting device -Design, manufacture and test for the pressure-resisting ...

Energy Technology Data Exchange (ETDEWEB)

Tests have recently been performed at Fermilab in order to measure the energy losses due to eddy currents and iron and superconductor magnetization. These measurements were performed on six 1.5m long model magnets and eight 15m long full scale collider dipole magnets. AC losses were measured as a function of ramp rate using sawtooth ramps from 500, to 5000 Amps for both types of magnets, while bipolar studies were additionally performed on some of the short magnets. The measured magnet voltage and current for a complete cycle are digitally integrated to yield the energy loss per cycle. Measurement reproducibility is typically 5%, with good agreement between long magnet measurements and extrapolations from short magnet measurement results. Magnetization loss measurements among similar ...

Energy Technology Data Exchange (ETDEWEB)

We report the results of characterization of nonlinear refractive index of the composite material produced by MeV Ag ion implantation of LiNbO{sub 3} crystal (z-cut). The material after implantation exhibited a linear optical absorption spectrum with the surface plasmon peak near 430 nm attributed to the colloidal silver nanoclusters. Heat treatment of the material at 500 C caused a shift of the absorption peak to 550 nm. The nonlinear refractive index of the sample after heat treatment was measured in the region of the absorption peak with the Z-scan technique using a tunable picosecond laser source (4.5 ps pulse width). The experimental data were compared against the reference sample made of MeV Cu implanted silica with the absorption peak in the same region. The nonlinear index of the Ag implanted LiNbO{sub 3} sample produced at five times less fluence is on average two times greater than that of the reference. (orig.) ...

UK PubMed Central (United Kingdom)

OBJECTIVESAlthough several studies suggest that slow gait speed is a predictor of falls, it may also be a protective mechanism to prevent falls. Further, fast walking...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Recent earthquake disasters have revealed the importance of countermeasures against soil Liquefaction in seismic design. In particular, the 1995 Hyogoken Nanbu earthquake caused several types of severe damages to pile foundations. This paper describes an analysis method for soil liquefaction using simple parameters such as SPT-N values and seismic response analyses for the pile-supported structure to consider soil-structure interaction effects and soil non-linearity using a modified Penzien model. It is important to find a way to determine the region of surrounding soil whose behavior is identical to that of piles. This paper adopts the thin layer element method to systematically determine the volume of the surrounding soil. The responses of pile-supported structure are similar, whether soil liquefaction and nonlinearity of pile are considered or not. However, the bending moment of pile become large as to soil liquefaction, and small as to ...

Energy Technology Data Exchange (ETDEWEB)

Removing noise from data is often the first step in data analysis. Denoising techniques should not only reduce the noise, but do so without blurring or changing the location of the edges. Many approaches have been proposed to accomplish this; in this paper, they focus on one such approach, namely the use of non-linear diffusion operators. This approach has been studied extensively from a theoretical viewpoint ever since the 1987 work of Perona and Malik showed that non-linear filters outperformed the more traditional linear Canny edge detector. They complement this theoretical work by investigating the performance of several isotropic diffusion operators on test images from scientific domains. They explore the effects of various parameters such as the choice of diffusivity function, explicit and implicit methods for the discretization of the PDE, and approaches for the spatial discretization of the non-linear operator etc. ...