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Magnesium fructose-1,6-diphosphate is a novel agent of antimyocardial ischaemia. In the present study, the subchronic toxicity of magnesium fructose-1,6-diphosphate was investigated after 13-week repeated intravenous administration in beagle dogs. The animals received doses of 0, 75, 150 and 300 mg/kg/day (three males and three females for each dose). During the study period, clinical signs, mortality, body weights, food consumption, electrocardiogram, urinalysis, haematology, clinical biochemistry, macroscopic findings, organ weights and histopathology were examined. The administration of magnesium fructose-1,6-diphosphate resulted in increased incidence of clinical signs, including salivation and emesis. These effects were transient and were noted in almost all dogs given 300 mg/kg/day a...

UK PubMed Central (United Kingdom)

ObjectiveThis study sought to determine whether differential treatment effects in the targeted mechanisms of change and eating disorder (ED) symptoms are associated...Full Text Available

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Background:- Diagnoses of paediatric bipolar disorder have increased over the last two decades in the United States, where high levels of comorbidity with ADHD have also been reported. Aims:- To explore how British clinicians apply these diagnoses. Method:- We compared 378 young people under the age of 18 who received a diagnosis of bipolar disorder and/or ADHD from a large NHS mental health trust between 1992 and 2007. Results:- Children with bipolar disorder were rare in this sample (n-=-35, 1.0%), particularly under the age of 13 (n-=-9, 0.3%). Children with bipolar disorder presented more often with affective and psychotic symptoms than children with ADHD. Irritability was common in both disorders. Core ADHD symptoms were prevalent in both conditions but occurred in a greater proportio...

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Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobehavioral disorder afflicting adults worldwide. This article is an update on the evidence supporting medications for adult ADHD, with particular emphasis on cardiovascular implications. Relevant clinical literature was sought using PubMed searches, with an emphasis on new reports from April 2009 to April 2011. This review describes the efficacy and general tolerability of stimulant and nonstimulant medications for adults with ADHD as seen in contemporary clinical trials. Cardiovascular response to medications for ADHD is primarily seen in heart rate and blood pressure elevations, while less is known about the etiology of rare cardiovascular events or long-term sequelae. Further research is indicated to delineate clinical an...

UK PubMed Central (United Kingdom)

Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome type B) is a metabolic disorder with devastating clinical characteristics starting in early childhood and leading to premature death. A...Full Text Available

UK PubMed Central (United Kingdom)

The symptoms of two patients with bilateral cortical auditory lesions evolved from cortical deafness to other auditory syndromes: generalised auditory agnosia, amusia and/or pure word deafness, and...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Major depressive disorder and alcohol dependence are common and serious mental illnesses. There is a great interest in discovering useful treatments for both mood symptoms and alcohol abuse in those patients with depressive disorders and comorbid alcohol dependence. The primary purpose of this study was to evaluate the effectiveness and tolerability of mirtazapine for the treatment of patients with alcohol dependence comorbid with a depressive disorder in an open label, naturalistic multicentre treatment setting. The 17-item Hamilton Depression Rating Scale (HDRS), the Hamilton Anxiety Rating Scale (HARS) and the Clinical Global Impression-Severity (CGI-S) scale were measured at baseline and at weeks 4 and 8 for the assessment of treatment effectiveness. Alcohol craving was measured using ...

Science.gov (United States)

Clinical-HINTS (Health Intelligence System) is a horizontally integrated decision support system (DSS) designed to meet the requirements for intelligent real-time clinical information management in critical care medical environments and to lay the foundation for the development of the next generation of intelligent medical instrumentation. The system presented was developed to refine and complement the information yielded by clinical laboratory investigations, thereby benefiting the management of the intensive care unit (ICU) patient. More specifically, Clinical-HINTS was developed to provide computer-based assistance with the acquisition, organisation and display, storage and retrieval, communication and generation of real-time patient-specific clinical information in an ICU. Clinical-HINTS is an object-oriented system developed in C+2 to run under Microsoft ...

British Library Electronic Table of Contents (United Kingdom)

To discuss and share knowledge around advances in the care of patients with thrombotic disorders, the Third International Symposium of Thrombosis and Anticoagulation was held in S?o Paulo, Brazil, from October 14?16, 2010. This scientific program was developed by clinicians for clinicians, and was promoted by four major clinical research institutes: the Brazilian Clinical Research Institute, the Duke Clinical Research Institute of the Duke University School of Medicine, the Canadian VIGOUR Centre, and the Uppsala Clinical Research Center. Comprising 3?days of academic presentations and open discussion, the symposium had as its primary goal to educate, motivate, and inspire internists, cardiologists, hematologists, and other physicians by convening national and international visionaries, th...

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No abstract prepared.

Science.gov (United States)

Alcoholism; Anxiety Disorders; Generalized Anxiety Disorder; Post-Traumatic Stress Disorder; Panic Disorder; Obsessive-Compulsive Disorder

British Library Electronic Table of Contents (United Kingdom)

Chorea-ballism is a rare form of movement disorder complicated by severe hyperglycaemia and in association with a contralateral basal ganglia lesion. We analysed the clinical characteristics of 25 Korean patients with chorea-ballism associated with nonketotic hyperglycaemia or diabetic ketoacidosis. Possible mechanisms of disease are also discussed.

Science.gov (United States)

Preterm children born before 32 weeks of gestation represent 1% of the annual births in Switzerland, and are the most at risk of neurodevelopmental disabilities. A neurological surveillance is thus implemented in the neonatal units, and multidisciplinary neurodevelopmental follow-up is offered to all our preterm patients. The follow-up clinics of the University hospitals in Lausanne and Geneva follow the Swiss guidelines for follow-up. An extended history and neurological examination is taken at each appointment, and a standardized test of development is performed. These examinations, which take place between the ages of 3 months and 9 years old, allow the early identification and treatment of developmental disorders frequent in this population, such as motor, cognitive or behavioral disorders, as well as the monitoring of the quality of neonatal care. PMID:21452511

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Children with attention-deficit/hyperactivity disorder (ADHD) often have poor relationships with peers. However, research on this topic has predominantly focused on boys. This study considered child gender, ADHD status, and dimensionally assessed conduct problems as predictors of peer relationship difficulties. Participants were 125 children (ages 6-10; 67% male), 63 with clinical diagnoses of ADHD and 62 non-ADHD comparison youth. Conduct problems were reported by teachers and observed in a lab playgroup. Peer relationships were assessed by parent report, teacher report, and peer sociometric nominations in the playgroup. Results suggested that children with ADHD, as well as those with high conduct problems, displayed more impaired peer relationships than did comparison children and those ...

British Library Electronic Table of Contents (United Kingdom)

Alcohol dependence (AD) is clinically and etiologically heterogeneous. The goal of this study was to explore AD subtypes among a sample of 1221 participants in the Irish Affected Sib Pair Study of Alcohol Dependence, all of whom met DSM-IV criteria for AD. Variables used to identify the subtypes included major depressive disorder, antisocial personality disorder, illicit drug dependence (cannabis, sedatives, stimulants, cocaine, opioids, and hallucinogens), nicotine dependence, the personality traits of neuroticism and novelty seeking, and early alcohol use. Using latent class analysis, a 3-class solution was identified as the most parsimonious description of the data. Individuals in a Mild class were least likely to have comorbid psychopathology, whereas a severe class had highest probabi...

British Library Electronic Table of Contents (United Kingdom)

Driving is a complex task that can be a significant challenge for individuals with attention-deficit/hyperactivity disorder (ADHD). A slight lapse in attention or inhibition while driving (not uncommon in individuals with ADHD) can result in hazardous consequences for these individuals and their families. This is also an interesting clinical scenario for the treating physician, who is always trying to optimize the various treatment options for the patient. Despite such potentially perilous consequences for society, this subject only recently has received researchers? attention. This review paper highlights the psychological differences between drivers with and without ADHD and examines differences between these groups in various driving simulation models. Research updates involving pharmac...

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INTRODUCTION. We searched for a pathophysiologically based feature of major water electrolytes, which may define water quality better than the water hardness, respecting urinary calculus formation. MATERIALS AND METHODS. Utilizing a multistage stratified sampling, 2310 patients were diagnosed in the imaging centers of the provincial capitals in Iran between 2007 and 2008. These were composed of 1755 patients who were settled residents of 24 provincial capitals. Data on the regional drinking water composition, obtained from an accredited registry, and their relationships with the region's incidence of urinary calculi were evaluated by metaregression models. The stone risk index (defined as the ratio of calcium to magnesium-bicarbonate product in drinking water) was used to assess the risk of calculus formation. RESULTS. No correlation was found between the urinary calculus incidence and the amount of calcium, bicarbonate, or the total hardness of the drinking water. ...

Science.gov (United States)

PMID:3765433

UK PubMed Central (United Kingdom)

Fasting plasma concentrations of magnesium were measured by neutron activation analysis in 30 non-diabetics and 87 diabetics (55 non-insulin-treated, 32 insulin treated). Plasma concentrations of magnesium...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Aluminum toxicity has been implicated in the pathogenesis of a number of clinical disorders in patients with chronic renal failure on long-term intermittent hemodialysis treatment. The predominant disorders have been those involving either bone (osteomalacic dialysis osteodystrophy) or brain (dialysis encephalopathy). In nonuremic patients, an increased brain aluminum concentration has been implicated as a neurotoxic agent in the pathogenesis of Alzheimer's disease and was associated with experimental neurofibrillary degeneration in animals. The brain aluminum concentrations of patients dying with the syndrome of dialysis encephalopathy (dialysis dementia) are significantly higher than in dialyzed patients without the syndrome and in nondialyzed patients. Two potential sources for the increased tissue content of aluminum in patients on hemodialysis have been proposed: (1) intestinal absorption from aluminum ...

British Library Electronic Table of Contents (United Kingdom)

Lebers hereditary optic neuropathy (LHON), the most frequent mitochondrial disorder, is mostly due to three mitochondrial DNA (mtDNA) mutations in respiratory chain complex I subunit genes: 3460/ND1, 11778/ND4 and 14484/ND6. Despite considerable clinical evidences, a genetic modifying role of the mtDNA haplogroup background in the clinical expression of LHON remains experimentally unproven. We investigated the effect of mtDNA haplogroups on the assembly of oxidative phosphorylation (OXPHOS) complexes in transmitochondrial hybrids (cybrids) harboring the three common LHON mutations. The steady-state levels of respiratory chain complexes appeared normal in mutant cybrids. However, an accumulation of low molecular weight subcomplexes suggested a complex I assembly/stability defect, which was ...

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A case has been presented of an expanding, aggressive bone cyst in the scapula of an 11-year-old girl. The lesion had the appearance of a highly aggressive, cyst-like disorder that appeared to be benign. Biopsy and histological preparation confirmed the presence of a solitary bone cyst. The clinical, radiological, and pathological criteria associated with a solitary bone cyst, particularly in the scapula, were discussed and the literature was reviewed. The differential diagnosis was stressed and a number of examples of scapular lesions was presented radiologically, particularly lesions that might be confused with solitary bone cyst. (orig./SHA).

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Gas and plasma nitriding processes were executed in the magnesium with modification by titanium in search for an effective surface treatment method for magnesium alloys. Magnesium-nitrogen system has completely no solid solution or solubility, so that nitride should be only formed by eutectic reaction in the liquid phase. Hence, magnesium is difficult or nearly impossible to have its surface modified by nitriding. Addition of nitride forming element into magnesium enables us to lower the onset temperature of nitriding. Magnesium-titanium alloys with 1 to 5 wt% are yielded by the bulk mechanical alloying and, subjected to gas nitriding for various process conditions. Successful co-formation of Mg{sub 3}N{sub 2} as well as TiN becomes a proof to demonstrate the possibility of gas/plasma nitriding in the solid-state magnesium with aid of ...

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Using commercial AZ31 magnesium alloy sheets, we produced a foamable preform sheet containing titanium hydride (TiH{sub 2}) powder through diffusion-bonding and hot-rolling of four cycles. Heating the preform sheets in Ar atmosphere, we obtained closed-cell magnesium alloy foams with various porosities. The foamed specimen at 883 K showed the maximum porosities of 77%. (orig.)

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

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Magnesium alloys show a high specific strength and are therefore increasingly used for light-weight constructions in transportation industry.{sup [1,2]} To predict the behaviour of the material under the influence of cyclic loading it is vital to understand the fatigue behaviour of magnesium alloys. Only when understood properly, it is possible to fully apply the potential weight reduction by using magnesium alloys. A very important aspect in fatigue of magnesium alloys is the influence of a corrosive media and elevated temperatures, of which both are relevant in automotive applications. These two factors tend to have deleterious effects on magnesium alloys and therefore also have to be considered in investigations on the fatigue behaviour of magnesium alloys. (Abstract Copyright [2004], Wiley Periodicals, Inc.)

British Library Electronic Table of Contents (United Kingdom)

The relationship of attention-deficit/hyperactivity disorder (ADHD) to learning disorders was reviewed and included reading disability, mathematics learning disability, and nonverbal learning disability. Genetic, neuroimaging, and neuropsychological functioning were examined for each disorder, along with a discussion of any existing literature when ADHD co-occurred with the disorder. All the disorders were found to frequently co-occur with ADHD. A review of the underlying neuroanatomic and neurofunctional data found specific structures that frequently co-occur in these disorders with others that are specific to the individual diagnosis. Aberrations in structure and/or function were found for the caudate, corpus callosum, and cerebellum, making these structures sensitive for the disorder bu...

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The study was designed to determine the correlation between parenchymal lesions on MRI and depression. Thirty patients with depression satisfying the following criteria were selected: (1) 60 years or over at the time of MRI scanning, (2) no evidence of cerebrovascular disorder or dementia, and (3) no evidence of neurological findings such as extremity palsy. Seventy six patients with no history of psychiatric visits to a clinic served as controls. There was no significant difference in risk factors for cerebrovascular disorders, such as hypertension, diabetes mellitus, and ischemic heart disease, between the depressive group and the control group. MRI manifestations were semiquantitatively scored according to the periventricular hyperintensity (PVH), white matter hyperintensity (WMH), and pons hyperintensity (PH). All of the PVH score, WMH score, and cerebral enlargement index correlated with age. Although there was no ...

Science.gov (United States)

... Gorman said he broke issues down into three categories: anxiety disorders; pediatric behavioral disorders, such as attention deficit disorder; and ...

International Nuclear Information System (INIS)

The OASIS Registry started annual collection of longitudinal data on patients on home parenteral nutrition (HPN) in 1984. This report describes outcome profiles on 1594 HPN patients in seven disease categories. Analysis showed clinical outcome was principally a reflection of the underlying diagnosis. Patients with Crohn's disease, ischemic bowel disease, motility disorders, radiation enteritis, and congenital bowel dysfunction all had a fairly long-term clinical outcome, whereas those with active cancer and acquired immunodeficiency syndrome (AIDS) had a short-term outcome. The long-term group had a 3-year survival rate of 65 to 80%, they averaged 2.6 complications requiring hospitalization per year, and 49% experienced complete rehabilitation. The short-term group had a mean survival of 6 months; they averaged 4.6 complications per year and about 15% experienced complete rehabilitation. The registry data also indicated HPN ...

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Plastic formability of cast magnesium alloy that were hot rolled after roll strip casting was investigated to ascertain the feasibility of semi-solid strip casting process of AZ31B magnesium alloy. Hot rolling and heat treatment conditions were changed to examine which conditions were appropriate for producing AZ31B wrought magnesium alloys after strip casting process. Microscopic observation of the crystals of the manufactured wrought magnesium alloys was performed. It has been found that a limiting drawing ratio of 2.7 was possible in a warm deep drawing test of the cast magnesium alloy sheets after being hot rolled. (orig.)

Science.gov (United States)

Hereditary hemorrhagic telangiectasia (Osler-Rendu-Weber disease) is a genetic disorder with autosomal dominance, variable penetrance, and an estimated prevalence of 1/10,000 inhabitants in France. Diagnosis is based on clinical criteria including epistaxis, telangiectasia, visceral manifestations, and familial occurrence. Pulmonary arteriovenous malformations, present in 15-33% of patients, are its primary visceral complications. The disease may be revealed by infectious and ischemic neurological manifestations due to paradoxical embolism. The high frequency of neurologic complications even in asymptomatic patients justifies systematic screening for pulmonary arteriovenous malformations. Treatment of these malformations is based on percutaneous transcatheter coil embolization of the feeding artery. Pulmonary arterial hypertension is rare in this disease. It may be due to systemic arteriovenous shunting in the liver, which increases cardiac ...

British Library Electronic Table of Contents (United Kingdom)

Knee osteoarthritis (OA) is a common degenerative joint disorder and a major cause of pain and disability. The hypothesis tested in this study was that the passion fruit peel extract (PFP), a flavonoid-rich dietary supplement, would reduce symptoms due to knee OA. Thirty-three OA patients were enrolled in a randomized, double-blind, placebo-controlled trial with parallel-group design. Patients received either placebo or PFP pills (150 mg, daily) in a double-blinded fashion for 2 months. The OA clinical symptoms were evaluated monthly with Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index. In the PFP group, there was a significant improvement in total WOMAC score and WOMAC subscale score of physical function after 30 days and pain after 60 days. At 60 days, reductions o...

DEFF Research Database (Denmark)

Mutations in the FGD1 gene have been shown to cause Aarskog-Scott syndrome (AAS), or facio-digito-genital dysplasia (OMIM#305400), an X-linked disorder characterized by distinctive genital and skeletal developmental abnormalities with a broad spectrum of clinical phenotypes. To date, 20 distinct mutations have been reported, but little phenotypic data are available on patients with molecularly confirmed AAS. In the present study, we report on our experience of screening for mutations in the FGD1 gene in a cohort of 60 European patients with a clinically suspected diagnosis of AAS. We identified nine novel mutations in 11 patients (detection rate of 18.33%), including three missense mutations (p.R402Q; p.S558W; p.K748E), four truncating mutations (p.Y530X; p.R656X; c.806delC; c.1620delC), one in-frame deletion (c.2020_2022delGAG) and the first reported splice site mutation (c.1935+3A>C). A recurrent mutation (p.R656X) was ...

Science.gov (United States)

Not Available

Science.gov (United States)

Attention Deficit Hyperactivity Disorder

Medline Plus

... which extend beyond the upper airway. These include attention deficit hyperactivity disorder, learning disorders, failure to thrive, and enuresis. Tonsillectomies ...

International Nuclear Information System (INIS)

Biological wound dressings sterilized with gamma radiation, such as amnion and pig skin, are a reality in Mexico. These tissues are currently processed in the tissue bank and sterilized in the Gamma Industrial Irradiation Plant; both facilities belong to the Instituto Nacional de Investigaciones Nucleares (ININ) (National Institute of Nuclear Research). With the strong support of the International Atomic Energy Agency, the bank was established at the ININ and the Mexican Ministry of Health issued its sanitary license on July 7, 1999. The Quality Management System of the bank was certified by ISO 9001:2000 on August 1, 2003; the scope of the system is 'Research, Development and Processing of Biological Tissues Sterilized with Gamma Radiation'. At present, more than 150 patients from 16 hospitals have been successfully treated with these tissues. This paper presents a brief description of the tissue processing, as well as the present Mexican clinical experience with ...

KoreaScience (Korea)

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Science.gov (United States)

The extraction of magnesium by tributyl phosphate from KI solutions was investigated. With increasing KI and TBP concentrations, the extraction increased. The maximum extraction (82%) was attained at pH 4, and it did not decrease with a further pH increase. With decreasing pH, the extraction decreased because of HI extraction. The magnesium was extracted as the compound MgI/sub 2/ x 4TBP. Complexone III (at pH 3-4) does not affect the extraction of magnesium, which makes it possible to use it to mask other metals.

Energy Technology Data Exchange (ETDEWEB)

Two extruded magnesium alloys, AZ31 and AZ61 were selected to evaluate the influence of process parameters on the material forgeability. The processing parameters considered for forging magnesium alloys were: compression load in the range 55 KN to 60 KN and forging temperature, in the range of ambient temperature to 300 C. Uniaxial compression tests were conducted to establish the strain-temperature relationship. The influences of process parameters on the microstructure were also evaluated. (orig.)

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Measurements of the double-electron-capture process in which a positive ion of iodine becomes a negative ion in a single collision with a magnesium atom are reported between 20 and 90 keV. The cross section is comparable to that for the rare gases and not as large as might be expected from a two-valence-electron atom. This process is probably insignificant in the production of negative ion beams using a magnesium-vapor target.

Science.gov (United States)

Objective:? Primary hyperparathyroidism (HPT) is characterised by autonomous secretion of PTH from enlarged parathyroid glands leading, in most patients, to asymptomatic hypercalcaemia. Familial hypocalciuric hypercalcaemia (FHH) is an autosomal dominant disorder caused by inactivating mutations in the calcium sensing receptor (CaSR) gene; it is characterised by lifelong and usually asymptomatic hypercalcaemia. Establishing the correct diagnosis is important because surgery can be curative in HPT, but ineffective in FHH. There is overlap in the diagnostic criteria for the two disorders and some patients carrying inactivating mutations in the CaSR gene, which is suggestive of FHH, also have HPT with hyperplastic parathyroid glands or adenomas. Design and Patients:? CaSR gene mutations were analyzed and clinical and biochemical parameters evaluated in 139 consecutive out-patients presenting with hypercalcaemia and suspected ...

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This paper deals with an experimental study of ultra-precision diamond cutting of magnesium alloy (AZ31). In order to investigate the machinability such as the cutting force and the surface integrity and understand the problems in a micro cutting, the experiments on the diamond cutting of magnesium alloy and pure aluminum with an ultra-precision turning machine has been carried out. The machinability of magnesium alloy was compared with that of pure aluminum and discussed. Consequently, both the thrust force component and the surface roughness obtained by cutting of magnesium alloy became larger than that of pure aluminum. It was also found that the inclusions or the defects in the work material caused to generate the scratches on the finished surface and influenced the integrity of mirror surface. (orig.)

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Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiological disorder of early childhood onset. Defining symptoms are chronic impairments of attention, impulse control and motor hyperactivity that frequently persist until adulthood. Miscellaneous causes of the disorder have been discussed. Accumulating evidence from imaging- and molecular genetic studies strengthened the theory of ADHS being a predominantly inherited disorder of neurobiological origin. In the last 15 years, non-invasive brain imaging methods were successfully implemented in pediatric research. Functional magnetic resonance imaging studies gave major insight into the neurobiological correlates of executive malfunction, inhibitory deficits and psychomotoric soft signs. These findings are in good accordance with brain morphometric data indicating a significant volumetric decrease of major components of striato-thalamo-cortical ...

UK PubMed Central (United Kingdom)

Functional gastrointestinal disorders (FGIDs) represent a common and important class of disorders within gastroenterology. RomeI, the first edition was published in 1994, with symptom-based diagnostic...Full Text Available

UK PubMed Central (United Kingdom)

Objective:This the first of two articles reviewing the scientific literature on the evaluation and treatment of circadian rhythm sleep disorders (CRSDs), employing the methodology...Full Text Available

Science.gov (United States)

...8Eligibility Criteria: Emotional/Behavioral Disorders Guidance for Paragraph...at-risk for emotional/behavioral disorders and their parents to help...Evaluation Team for Emotional/behavioral Disorders: Psychologist,...

UK PubMed Central (United Kingdom)

In the last decade, there has been an increase in interest in the burden of chronic and disabling health conditions that are not necessarily fatal, such as the mental disorders. This review...Full Text Available

UK PubMed Central (United Kingdom)

A large group of diseases, termed protein misfolding disorders, share the common feature of the accumulation of misfolded proteins. The possibility of a common mechanism underlying either the pathogenesis...Full Text Available

UK PubMed Central (United Kingdom)

Gastric acid hypersecretory states are a group of disorders characterized by basal hypersecretion of gastric acid and historically include a number of disorders associated with hypergastrinemia,...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVETo evaluate trends in costs of ambulatory care related to female pelvic floor disorders (PFD) in the United States.STUDY DESIGNFull Text Available

Energy Technology Data Exchange (ETDEWEB)

Increase usage of magnesium components in the portable electronics industries has propelled considerable research interest on the development of magnesium forging. There have been some studies done in the area of sheet metal forming and forging of axis-symmetrical parts of magnesium alloys but there are very little work done on the plane strain backward extrusion of magnesium alloy. This paper deals with the analysis of plane strain extrusion of magnesium alloy, AZ31, using numerical modeling at different extrusion conditions of temperatures and friction coefficients. A commercially available finite element package, ANSYS/LSDYNA, was used in the finite element analysis. FE simulated results, material deformation, punch force and stress/strain distributions, were compared with actual experimental data. From the numerical analysis, a decrease in forging temperature from 300 C to 250 C ...

Energy Technology Data Exchange (ETDEWEB)

To improve the surface properties of magnesium alloy, a lining process using shot peening was carried out. The lining of magnesium alloy with metals such as titanium and nickel is useful in heightening the corrosion and wear properties for the components. In the shot peening experiment, the foil set on the magnesium workpiece is pelted with many shots at a high velocity. The foil is bonded to the surface of the workpiece due to plastic deformation induced by the collision of the shots. A pure aluminum foil is inserted between the hard foil and magnesium workpiece to assist the bonding. To heighten the bondability, the foil and workpiece are heated and the flow stresses of the metals are reduced. In this experiment, a centrifugal shot peening machine with an electrical heater was employed. The workpieces were commercially magnesium alloys AZ31B and AZ91D, and the foils were ...

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Objective. The aim of this study was to assess the capability of high-resolution images obtained with a commercially available pelvic phased-array surface coil to demonstrate normal hip anatomy. Design. We retrospectively analyzed the oblique coronal magnetic resonance (MR) images of hips of 36 consecutive patients acquired on a 1.5-T clinical imager using a pelvic phased-array coil as a receiver, a 16-20 cm field of view, and 5 mm slice thickness. Patients. Thirty-six patients were studied, age 15-81 years. There were 20 males and 16 females. Results and conclusions. The articular cartilage, cortex, superior labrum, and iliofemoral ligament were well visualized on proton density weighted fat saturation (PDF) images. The femoral and obturator vessels, obturator nerve, and various muscles were easily seen on T1-weighted images. High-resolution imaging of the hip is achievable in a reasonable amount of time using newer phased-array surface coils and may play an ...

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Hepatobiliary scintigraphy is the only non-invasive technique providing real-time assessment of hepatocytes function and bile progression from the liver to the intestine; for this reason it is of great importance in the study of jaundice and many other disorders of the liver and the biliary tract in children. Ultrasonography is the initial method of evaluating the intra- and extrahepatic bile ducts dilatation: the differential diagnosis between biliary atresia and neonatal hepatitis cannot however be done without hepatobiliary scintigraphy. Cystic fibrosis patients also require hepatobiliary scintigraphy; liver and biliary tract disease can really occur independently of the underlying disease severity and the presence of steatorrhoea. Hepatobiliary imaging in children who have undergone liver transplantation is of major importance; it can assess vascularity, parenchymal function biliary drainage, possible presence of a bile leak and obstruction; it has very good ...

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Computed tomography (CT) of the thorax shows early promise of important diagnostic advances. We believe that CT often provides information superior to that provided by standard roentgenographic techniques, is capable of significantly influencing patient management, and in selected instances, offers unique information not available by other methods. Computed tomography permits the imaging of mediastinal structures not possible with conventional roentgenographic methods and can diagnose with certainty benign mediastinal conditions such as pericardial cysts and focal or diffuse accumulations of fat. It is ideal for detecting pleural abnormalities and for displaying underlying parenchymal disease in patients with complex pleuroparenchymal shadows on conventional films. Pulmonary metastases unseen on the plain chest film can be detected with greater sensitivity than by any other method. Future applications of CT include the staging of mediastinal lymph nodes in bronchogenic carcinoma, the ...

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Stargardt disease (STGD) and fundus flavimaculatus are infrequent autosomal recessive conditions characterized by a juvenile macular dystrophy and variable degrees of peripheral retinal changes. Linkage analysis performed in 47 STGD/fundus flavimaculatus families demonstrated significant linkage to 13 polymorphic DNA markers on chromosome 1p. The maximum combined two-point lod score was 32.7 (maximum recombination fraction [{theta}{sub max}] = .006) with the polymorphic marker D1S188. Our data demonstrate that STGD and fundus flavimaculatus are the same disorder clinically and genetically and provide further evidence for genetic homogeneity of this phenotype. Analysis of recombination on disease chromosomes placed the STGD gene within a 4-cM interval between markers D1S435 and D1S236. A physical map was constructed of a YAC contig flanking STGD, from markers D1S500 to D1S495, and includes the critical interval delineated by historical ...

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Involvement of the dopaminergic system has been suggested in patients suffering from attention deficit hyperactivity disorder (ADHD) since the symptoms can be successfully treated with methylphenidate, a potent blocker of the dopamine transporter (DAT). This study reports the findings on the status of the DAT in adults with ADHD before and after commencement of treatment with methylphenidate, as measured using [{sup 99m}Tc]TRODAT-1. Seventeen patients (seven males, ten females, aged 21-64 years, mean 38 years) were examined before and after the initiation of methylphenidate treatment (3 x 5 mg/day). All subjects were injected with 800 MBq [{sup 99m}Tc]TRODAT-1 and imaged 3 h p.i. Single-photon emission tomography (SPET) scans were acquired using a triple-headed gamma camera. For semi-quantitative evaluation of the DAT, transverse slices corrected for attenuation were used to calculate specific binding in the striatum, with the cerebellum used as background ...

Energy Technology Data Exchange (ETDEWEB)

A chromium-free conversion coating for magnesium alloys were described. The conversion coating could be obtained when AZ31D magnesium alloy was immersed in a solution containing a manganese salt, phosphate and an inhibitor. Corrosion resistance of the chemical conversion coating was evaluated by anodizing polarization curve and salt immersion. XRD analysis showed that the conversion coating was mainly composed of Mn{sub 3}(PO{sub 4}){sub 2}. The morphology of the coating is observed by using SEM. The effect of electrolyte pH and concentration of inhibitor on coating growth are investigated. (orig.)

Science.gov (United States)

... alloys--Lanthanum-- Magnesium--Magnasium &11oy8--Hagn*31Uft compounds--Manxganese--Manganes. alloys-- Mercury ...

International Nuclear Information System (INIS)

Magnesium alloys have been increasingly used in automotive and electronic industries because of their excellent strength to weight ratio and EMI shielding properties. However, magnesium alloys have low formability at room temperature due to their unique mechanical behavior (twinning and untwining), prompting for forming at an elevated temperature. In this study, a temperature dependent constitutive model for magnesium alloy (AZ31B) sheet is developed. A hardening law based on non linear kinematic hardening model is used to consider Bauschinger effect properly. Material parameters are determined from a series of uni-axial cyclic experiments (T-C-T or C-T-C) with the temperature ranging 150-250 deg. C. The influence of temperature on the constitutive equation is introduced by the material parameters assumed to be functions of temperature. Fitting process of the assumed model to measured data is presented and the results are ...

International Nuclear Information System (INIS)

One of the major concerns during high speed welding of magnesium alloys is the presence of porosity in the weld metal that can deteriorate mechanical properties. This study seeks to analyze the presence method and quantity of pore during hybrid laser-tungsten inert gas arc (TIG) welding of magnesium alloy AZ31B by radiography, optical microscopy and electron probe microanalysis (EMPA). At the same time, it identifies both the mechanism of pore formation and a remedy for this problem. The experimental results indicate that lacking of shielding gas for laser beam is the dominant cause of macroporosity formation during the hybrid of laser-TIG welding of magnesium Alloys AZ31B plate, and hydrogen is not main cause to form large pores. A favorable weld without porosity can be obtained by appending lateral shielding gas for laser beam.

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In this paper, for an acceleration of utilization of magnesium alloy which is being interested in recent years, friction welding of AZ31 magnesium alloy was carried out, and the joint performance was discussed in relation to the deformation heat input in the upset stage and upset loss as a evaluation factor. Where, the deformation heat input in the upset stage is mechanical work represented by the product of upset speed and axial pressure. As a result, it was made clear that the friction welding of AZ31 magnesium alloy was easy in the atmosphere, and good welded joints without a non- adhesion area at the weld interface could de obtained. Moreover, the evaluation factors discussed were possible to evaluate to joint performance. (orig.)

British Library Electronic Table of Contents (United Kingdom)

A microanalytical characterization of cast magnesium alloys of eutectic origin based on the Mg?Al?Ca ternary matrix system has been carried out in order to investigate the influence of alloying elements on their microstructure as well as microchemistry-processing-microstructural relations using structure-sensitive techniques of electron microscopy, mechanical spectroscopy (internal friction), X-ray diffractometry, and advanced microanalytical methods including electron probe compositional analysis. Following the data obtained here there is direct correlation of microstructure with creep properties of the new experimental magnesium alloys. The creep and heat-induced properties of the multicomponent magnesium alloys containing low range of inexpensive additions of titanium (0.07?0.2%) or str...

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Although magnesium is not attacked by hydrocarbons, it reacts vigorously with anhydrous methanol, raising concerns about the compatibility of the metal with methanol blend fuels. This paper describes the behavior of magnesium alloys in laboratory tests in static contact with methanol-containing fuels at 110/sup 0/F. Water in small concentrations (above 0.25% by weight of the methanol content) is shown to prevent the destructive attack of magnesium by these fuels. The required water content is well within the water tolerance of methanol-GTBA (gasoline grade tertiary-butyl alcohol) cosolvent fuel blends. Die cast AZ91HP shows greater resistance to methanol reaction than does AZ31B sheet.

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A new technique was proposed in order to improve poor corrosion resistance in magnesium. That is, magnesium hydroxide film was formed on the surface of 3 N-Mg by artificial corrosion in 1% MgCl{sub 2} solution for 3.6 ks, which followed by oxidation at 673 K for 3.6 ks in air. Corrosion resistance was evaluated by salt immersion tests in 1% NaCl solution under in situ laser microscopic observations. Bubble evolution, which occurred immediately at the beginning of the immersion test in the case of non-treated specimen, was suppressed by the process. And also, formation of filiform corrosion was suppressed for about 3.6 ks, which occurred at 180 s in the non-treated specimen. (orig.)

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International Nuclear Information System (INIS)

... fields magnetic moments neel temperature neutron diffraction order-disorder

International Nuclear Information System (INIS)

Gastrointestinal lymphomas are almost exclusively of a non Hodgkin's type. The Western form is characterized by a higher incidence of stomach location (50 %), a MALT type (mucosa associated lymphoid tissue) (40 %), a B-cell type (90 %), and a high grade (55 %). Chronic infection with Helicobacter pylori is an important risk factor. Mediterranean lymphomas form a particular clinical and pathological entity with diffuse involvement of the small bowel and are frequently being associated with a chronic malabsorption disorder. Eradication of Helicobacter pylori in early lymphomas, and the use of tetracyclines in early Mediterranean lymphomas, have been shown to induce durable remissions. For more advanced gastric lymphomas, treatment usually consists of anthracycline-based chemotherapy followed by involved field radiotherapy. Surgery is usually reserved for complications such as perforation or bleeding, or in some selected cases for salvage after ...

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The puborectalis syndrome is a defecation disorder supported by the nonrelaxation of puborectalis sling with consequent dyschezia. They report on a series of 98 patients submitted to clinical examination, defecography, anorectal manometry, electromyography and intestinal transit time studies. The main symptoms of puborectalis syndrome in their patients were incomplete defecation (89 %) and intermittent evacuation (63 %); 28 % of patients turned to finger defecation. In all patients, defecography showed an abnormal increase in puborectalis impression on the posterior anorectal wall, reduced anorectal angle opening under straining (mean value: 113 deg) and prolonged expulsion time with barium pooling in the ampulla (mean evacuation time: 38 seconds). Such anorectal abnormalities as rectal mucosal prolapse (47 cases) and anterior rectocele (36 cases) were also associated. In 33 of 98 patients (34 % of cases), sling assessment by bidigital ...

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In order to investigate the extrusion characteristics of magnesium alloy (AZ31), a computer simulation was attempted. Tensile properties of as-cast billet with different strain rates were incorporated into the simulation. The results showed a great change in distribution of stress and strain at near die region by the ram travel. It was found that the average grain size at longitudinal edge of the extruded sheet was smaller than that at center region, which might be attributed to recrystallization caused by severe plastic deformation. (orig.)

International Nuclear Information System (INIS)

We present a sample preparation method for measuring magnesium in individual whole lymphocytes by electron probe X-ray microanalysis. We use Burkitt's lymphoma cells in culture as the test sample and compare X-ray microanalysis of individual cells with atomic absorption analysis of pooled cell populations. We determine the magnesium peak-to-local continuum X-ray intensity ratio by electron probe X-ray microanalysis and calculate a mean cell magnesium concentration of 39 +- 19 mmol/kg dry weight from analysis of 100 cells. We determine a mean cell magnesium concentration of 34 +- 4 mmol/kg dry weight by atomic absorption analysis of pooled cells in three cell cultures. The mean cell magnesium concentrations determined by the two methods are not significantly different. We find a 10% coefficient of variation for both methods of analysis and a 30% coefficient of variation in ...

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PVD-chromium-nitride coated samples of substrates of the magnesium alloy AZ91hp and the roller and ball bearing steel 100Cr6 were investigated regarding structure, mechanical characteristics, adhesion and internal stresses. For the coatings the parameters layer thickness and substrate BIAS voltage were varied. Both substrate materials were coated in one lad. Results of the X-ray analysis of the internal stresses show significant differences between the coated magnesium and the coated steel substrates. In the case of the variation of the substrate BIAS voltage, for the coated steel a dependency of the internal stresses to coating parameters could be obtained. For the coated magnesium no dependency was recognizable. The coating structure was examined with scanning electron microscopy. Element depth profiles of the coated samples were performed with SIMS. (orig.)

British Library Electronic Table of Contents (United Kingdom)

Lisy ME, Jarvis KB, DelBello MP, Mills NP, Weber WA, Fleck D, Strakowski SM, Adler CM. Progressive neurostructural changes in adolescent and adult patients with bipolar disorder.-Bipolar Disord 2011: 13: 396-405. 2011 The Authors.-Journal compilation 2011 John Wiley & Sons A/S. Objectives:- Several lines of evidence suggest that bipolar disorder is associated with progressive changes in gray matter volume (GMV), particularly in brain structures involved in emotional regulation and expression. The majority of these studies however, have been cross-sectional in nature. In this study we compared baseline and follow-up scans in groups of bipolar disorder and healthy subjects. We hypothesized bipolar disorder subjects would demonstrate significant GMV changes over time. Methods:- A total of 58 ...

International Nuclear Information System (INIS)

An experimental study on superplastic forming behaviors and microstructure characters of commercial magnesium alloy sheet AZ31B is presented in this paper. The main experimental results show that the commercial magnesium alloy AZ31B sheet has superplastic capability. For the received sheet without any pre-processing, the maximum elongation is 295%. The dynamic recrystallization and grain refinement can be found, In the case of temperature =# 350 deg. C. The superplastic behaviors can be improved by controlling the dynamic recrystallization and grain refinement. Some experimental results of free superplastic bulging are presented in this paper. The results show that influence of temperature on forming capability is much less than the influences of temperature on elongation. In addition, the maximum principle strain.

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Materials and processing designs for advanced magnesium alloys with fine microstructures and superior properties were established by the combination of the repeated plastic working and the Mg{sub 2}Si synthesis in solid-state. The grain size was less than 1 {mu}m via RPW process due to its severe plastic working on raw powder. The hot extruded magnesium alloys produced in industries showed high ultimate tensile strength, e.g. 420{proportional_to}450 MPa, when employing Mg-Zn-Al-Ca-RE (Rare Earth) alloy coarse powder, having 0.5{proportional_to}2 mm diameter, as input materials. (orig.)

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Following the breakthrough for cast magnesium products, interest is now spreading to wrought applications - triggering a variety of technological questions. A major bottleneck in the manufacture of magnesium sections (profiles) by conventional hot extrusion is the low productivity, with extrusion speeds typically five to ten times lower than for comparable aluminium sections. This paper focuses on the use of hydrostatic extrusion as a means to overcome this problem. On the basis of an analytical model, it is clarified why and how process limits are affected by the process mechanics. Experimental work on the hydrostatic extrusion of the alloys M1A, ZM21 and AZ31 confirms that extrusion speed is indeed multiplied, whereas the resulting mechanical properties are similar to or better than those for conventional extrusions. (orig.)

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Car weight corresponds directly to fuel consumption and driving performance. So in order to improve the fuel efficiency and performance of a car the weight has to be reduced. Magnesium as a light metal offers a wide range of weight saving opportunities, especially Magnesium wrought alloys with their improved mechanical properties have a high potential for structural applications. Mechanical properties in terms of their quality and anisotropy are dependent on the microstructure of the material and can be characterized by their degree of inhomogeneity, their grain size distribution and their crystallographic texture. Therefore the orientation distribution of grains, the grain size, its size distribution, the chemical composition (precipitates) itself influence the mechanical parameters and their anisotropy. In this presentation first results of mechanical anisotropy are given: differences in yield stress, r-values and their relation to the ...

UK PubMed Central (United Kingdom)

Previous studies have shown that both bipolar disorder (BPD) and psychomotor agitation (PMA) are associated with substance dependence. These two findings have yet to be integrated, despite evidence...Full Text Available

UK PubMed Central (United Kingdom)

ObjectivesThe updated Rome III criteria for pediatric functional gastrointestinal disorders (FGIDs) include new FGID categories and changes to the Rome II criteria...Full Text Available

UK PubMed Central (United Kingdom)

In terms of managing thrombotic disorders, genotype-based individualized patient care emerged as early as 1994 when the association of factor V Leiden (G1691A), and later, prothrombin (G20210A),...Full Text Available

UK PubMed Central (United Kingdom)

The search for liability genes of the world's 2 major psychotic disorders, schizophrenia and bipolar disorder I (BP-I), has been extremely difficult even though evidence suggests that both are highly...Full Text Available

UK PubMed Central (United Kingdom)

Intrinsically disordered proteins are predicted to be highly abundant and play broad biological roles in eukaryotic cells. In particular, by virtue of their structural malleability and propensity...Full Text Available

UK PubMed Central (United Kingdom)

Speech and language disorders are some of the most common referral reasons to child development centers accounting for approximately 40% of cases. Stuttering is a disorder in which involuntary...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundGender differences in the prevalence and occupational consequences of musculoskeletal disorders (MSDs) are consistently found in epidemiological studies. The study investigated...Full Text Available

UK PubMed Central (United Kingdom)

Examination of a painful hip is fairly concise and reliable at detecting the presence of a hip joint problem. Hip joint disorders often go undetected, leading to the development of secondary disorders....Full Text Available

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Recent studies have reported that cognitive inflexibility associated with impairments in a frontal-striatal circuit and parietal region is a core cognitive deficit of obsessive-compulsive disorder (OCD)....Full Text Available

UK PubMed Central (United Kingdom)

Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of ∼80% indicating a substantial genetic component. Population genetics...Full Text Available

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The suitability of MR imaging versus computerized tomography in observation of brain development disorders in children are compared. 13 refs.

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... taker', Adaptive Behavior. In submission. Behavioral Disorders: Diagnostic Criteria for Re- Breazeal (Ferrell), C. (1998), A Motivational System for ...

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Loss of the sense of smell can be easily confirmed in any physician's office by having the patient try to identify various odors. The etiology of anosmia can be extremely varied, including nasopharyngeal disorders such as rhinitis and tumors; neurologic conditions such as head trauma, neoplasms, vascular lesions and infections of the central nervous system; viral infections; familial and congenital disorders; drugs; industrial exposure; endocrine diseases, and several other disorders. The prognosis of anosmia is guarded, and its treatment depends on the etiology.

International Nuclear Information System (INIS)

Luminescence and reflection spectra as well as luminescence kinetics of the 1 mol% Sm3+-doped crystalline lanthanum magnesium meta borate (LaMgB5O10) and gadolinium magnesium meta borate (GdMgB5O10) were analyzed. Materials were synthesized by conventional solid state route and showed bright orange-red emission under UV excitation. Emission spectra contain sharp and well resolved Sm3+4G5/2#->#6HJ transitions indicating a strong crystal-field effect. In case of gadolinium compound energy transfer between Gd3+ and Sm3+ was detected. The luminescent kinetics of the Sm3+ in analyzed powders is characterized by single exponential decay and experimental values vary in the range 2.2-2.4 ms. - Research highlights: ? Phosphorescence of samarium-doped lanthanide magnesium meta borates. ? Bright and well resolved orange-red emission of Sm3+ under UV excitation. ? Energy transfer from Gd3+ to Sm3+ in gadolinium ...

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The aim of this study as to determine the mechanisms involved in using ammonium fluoborate as a reducing atmosphere when preheating a high magnesium content aluminium alloy. Rutherford Backscattering (RBS) has been the major technique used in the analysis of samples, it revealed significant reduction in both the diffusion of magnesium to the surface and the calculated oxide thickness in the presence of NH{sub 4}BF{sub 4}. At temperatures above 500 deg C in air, SEM images revealed depressions and voids due to incipient melting at various stages, around the grain boundaries. Grain boundaries effectively acted as pipes aiding the diffusion of magnesium to the surface. These results have been verified through compositional analysis with both RBS and auger electron spectroscopy (AES). Results from NH{sub 4}BF{sub 4} atmosphere preheat conditions showed significant improvements. It was verified experimentally that above 500 deg ...

Science.gov (United States)

The catalytic effects of copper-aluminium-magnesium oxides in the oxidative coupling of phenylethyne is described. The importance of surface properties as a redox site are discussed.

UK PubMed Central (United Kingdom)

A novel therapeutic compound was found to induce bladder tumors in male rats. Given the location of the tumors and the increased amounts of calcium- and magnesium-containing solids found in the urine...Full Text Available

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The possibility of improving the cold formability of wrought magnesium alloys is considered in light of their good hot forming characteristics. Magnesium alloy AZ31B sheet is selected as a model system. Parameters affecting formability, such as strain hardening rate, strain rate sensitivity, and the degree of anisotropy are examined systematically by conducting tensile tests over a range of temperatures (room temperature to 250 C) and strain rates (1 x 10{sup -5} to 0.1 s{sup -1}). The plastic anisotropy and deformation texture evolution are examined in samples aligned with the sheet rolling and transverse directions. Polycrystal plasticity simulations using a viscoplastic self-consistent (VPSC) formulation are used to model the observed anisotropy and texture evolution. The adjustable parameters in the model are the relative critical resolved shear stresses of the dislocation mechanisms known to operate within magnesium. ...

International Nuclear Information System (INIS)

Chemical and phase homogeneity of titanium-niobium sponge, produced by a combined magnesium-thermic reduction of niobium pentachloride and titanium tetrachloride mixtures, is investigated. It is ascertained that a sponge consists of spherical shape particles and has a large number of pores. Particle sizes are reduced with niobium being substituted for titanium from 50-500 #mu#m for titanium sponge to 1-40 #mu#m for niobium one, which testifies to the bormation in a titanium-niobium sponge of an alloy and not a mechanical mixture. A number of solid solutions is detected by X-ray phase analysis. Lattice parameters are determined.

British Library Electronic Table of Contents (United Kingdom)

A new coumarin-based sensor molecule (L1) has been synthesized and this was found to bind calcium and magnesium ions more effectively as compared to other alkali/alkaline earth/lanthanide and certain transition metal ions. A significant enhancement in fluorescence intensity was observed on binding to Ca2+ and Mg2+ ions; while a minor quenching was observed for weakly bound Hg2+, Ni2+, Fe3+, and Co2+ ions. PET process, coupled with the ICT process, is proposed to explain the observed spectral response.

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Optimum conditions for microstructural control in industrial hot working of cast and homogenized AZ31 magnesium alloys are evaluated by using a processing map. The recommended window for bulk metal working of this alloy is the domain in the temperature range 300-450 C and strain rate range 1-10 s{sup -1}, and the optimum processing parameters are 400 C and 10 s{sup -1}, where grain-boundary self diffusion is the rate-controlling mechanism. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

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The superplastic characteristics and diffusion bonding behaviors were investigated in commercial 7475 aluminum alloy and AZ31 magnesium alloy sheets. In this study, the presently used materials behaved in a superplastic manner at {proportional_to} 773 K (7475Al) and {proportional_to} 523 K (AZ31). Then, by the theoretical relationship between pressure and time, these materials were successfully diffusion bonded at the superplastic temperatures. The bonding strength was more than 65 MPa. The experimental bonding conditions in high quality joining, times and pressures, were good agreed with prediction analysis. (orig.)

KoreaScience (Korea)

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UK PubMed Central (United Kingdom)

Objective: The paper describes and evaluates the use of Clinical Digital Libraries Project (CDLP) digital library collections in terms of their facilitation of timely clinical information...Full Text Available

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Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurobehavioral disorder affecting 5% to 10% of children. Although considered to be a highly familial disorder, ADHD heritability estimates of 60% to 80% highlight the considerable role that environmental factors may still play in disorder susceptibility. Proposed ADHD environmental risk factors include prenatal substance exposures, heavy metal and chemical exposures, nutritional factors, and lifestyle/psychosocial factors. This paper reviews the literature published in 2010 investigating the association between environmental risk factors and ADHD or related symptomatology. Sources of risk factor exposure and the proposed mechanism by which each exposure is linked to ADHD-related neurobehavioral changes are also reported. Metho...

Science.gov (United States)

Antiquitin (ATQ) deficiency is the main cause of pyridoxine dependent epilepsy characterized by early onset epileptic encephalopathy responsive to large dosages of pyridoxine. Despite seizure control most patients have intellectual disability. Folinic acid responsive seizures (FARS) are genetically identical to ATQ deficiency. ATQ functions as an aldehyde dehydrogenase (ALDH7A1) in the lysine degradation pathway. Its deficiency results in accumulation of ?-aminoadipic semialdehyde (AASA), piperideine-6-carboxylate (P6C) and pipecolic acid, which serve as diagnostic markers in urine, plasma, and CSF. To interrupt seizures a dose of 100mg of pyridoxine-HCl is given intravenously, or orally/enterally with 30mg/kg/day. First administration may result in respiratory arrest in responders, and thus treatment should be performed with support of respiratory management. To make sure that late and masked response is not missed, treatment with oral/enteral pyridoxine should be continued until ATQ ...

International Nuclear Information System (INIS)

The potential application of radioisotopes are not discussed in this review of trypanosome pathogenesis in cattle. Initially, structural changes in the lymphoid system are characterized by marked proliferation and germinal centre formation, whereas in long-standing infections the lymphoid organs become depleted. These changes appear associated with immunodepression. Anaemia dominates the clinical disease syndrome in bovine trypanosomiasis. It develops with the onset of parasitaemia and is largely haemolytic, resulting from increased red blood cell destruction by phagocytosis. Several factors may be involved in this process including haemolysins produced by the trypanosome, immunological mechanisms, fever, disseminated intravascular coagulation and an expanded and active mononuclear phagocytic system. During this phase of the disease, cattle respond well to chemotherapy. However, in later phases of the disease, when trypanosomes cannot be detected, the anaemia ...

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The typical MRI features of the most common pancreatic diseases, such as pancreatitis and adenocarcinoma of the pancreas, have been established. However, even in these common pancreatic disorders, MRI correlation with the underlying pathology is limited for clinical reasons. We emphasize MR-pathological correlation of inflammatory and neoplastic pancreatic changes, including pancreatitis, adenocarcinoma, acinar cell carcinoma, rare cystic and solid pancreatic neoplasms, and islet cell tumors. By highlighting the correlation of key pathological features with MR findings, a better understanding of the MR appearance of pancreatic pathology can be provided. In addition, MRI may prove a powerful tool in detection and characterization of pancreatic tumors. (orig.) [Deutsch] Das MR-tomographische Erscheinungsbild von Pankreatitiden und Adenokarzinomen des Pankreas, als den haeufigsten Pankreaserkrankungen, ist zwar ausreichend bekannt; allerdings ist ...

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The accurate measurement of a stress level is one of the most important issues in a stress diagnosis and its measurement could be of great value in clinical medicine. Stress has a potent effect on the spirit and physical condition of an individual. There are various methods available for its measurement. Some of the commonly used techniques for the diagnosis of a stress level include analysis of the body fluids, questionnaire assessments, psychophysiological evaluations and by determining heart rate variability (HRV) of subjects. However, the existing diagnostic methods have several defects like, a low sensitivity, inaccuracy and long of operation time. In this report, we present a diagnostic technology to detect a stress level which is the origin of various diseases. This method can be of great help in providing an early diagnosis through a biosensor and might play a vital role in preventing diseases like hypochondria and hypertension. Majority of the human ...

International Nuclear Information System (INIS)

Full text: Chronic fatigue syndrome (CFS) is a complex disorder characterised by profound fatigue and neuropsychiatric dysfunction. Previous studies with cerebral perfusion SPECT (rCBF) scans were performed with inhomogeneous patient populations and were not analysed with Statistical Parametric Mapping (SPM). We have used SPM to study subjects with moderate CFS based on the Fukuda criteria, who were not on medication and not depressed, compared to age matched control subjects. An apparent bimodal age distribution has been observed in CFS. Subjects were therefore divided into two age groups: 16-35 or under 35 (17 CFS, 11 control) and 36-61 or over 35 (15 CFS, 15 control). HMPAO brain SPECT was acquired on a 3-head camera. After lower window scatter subtraction, reconstruction with attenuation correction (mu=0.15/cm) and editing of facial activity, scans were spatially normalised (affine + 2x3x2 nonlinear) to SPM's anatomical space. SPM statistical analysis yielded ...

Science.gov (United States)

Background: Anxiety disorders are known to be common in the general population. Previous studies with adults with intellectual disabilities (IDs) report a prevalence of general anxiety disorder ranging from less than 2% to 17.4%. Little is known about associated factors in this population. This study investigates point prevalence of anxiety disorders and determines the factors independently associated with them. Methods: Information was collected with 1023 adults with IDs who participated in a large-scale, population-based study. All had a comprehensive physical and mental health assessment. The point prevalence of anxiety disorders according to different diagnostic criteria was determined, as were independently associated factors by using logistic regression analysis. Results: Three point eight per cent (95% CI = 2.7-5.2%) of the cohort had an anxiety disorder at the time of ...

Science.gov (United States)

The main objectives were to evaluate efficacy and acceptability of a developmentally sensitive cognitive behavioral therapy for anxiety-based school refusal in adolescence. Twenty school-refusing adolescents meeting DSM-IV anxiety disorder criteria participated in a non-randomized trial, together with parents and school staff. Outcome was assessed at post-treatment and 2-month follow-up. Treated adolescents showed significant and maintained improvements across primary outcome variables (school attendance; school-related fear; anxiety), with medium to large effect sizes. Half of the adolescents were free of any anxiety disorder at follow-up. Additional improvements were observed across secondary outcome variables (depression; overall functioning; adolescent and parent self-efficacy). The treatment was rated as acceptable by adolescents, parents, and school staff, which may help explain the very low attrition rate. Social anxiety ...

British Library Electronic Table of Contents (United Kingdom)

Transdifferentiation of an individual's own cells into functional differentiated cells to replace an organ's lost function would be a personalized approach to therapeutics. In this two part series, we will describe the progress toward establishing functional transdifferentiated adrenal cortical cells. In this article (Part 2), we describe the disorders of the adrenal cortex, therefore establishing why there is the need for personalized cell-based therapy for individuals with these disorders. We then present our pilot studies of cell transdifferentiation toward an adrenal cortical fate using genes described in the first article of this pair (Part 1).

Science.gov (United States)

... drugs, foods, environmental conditions, and behavioral disorders (1,8,10,17,18,24,29). In addition, we designed a self-rated ...

Medline Plus

... Spectrum Disorders (25) G Grief (3) H HIV & AIDS (15) I Infectious Diseases (22) Injection Drug Use ( ...

British Library Electronic Table of Contents (United Kingdom)

In children and adolescents the Second Generation Antipsychotics (SGAs) represent the class of psychotropic drugs whose use has grown more significantly in recent years: they are primarily used for treatment of patients with disruptive behavior disorders, mood disorders and pervasive developmental disorders or mental retardation. In order to compare the efficacy and tolerability of antipsychotics against placebo or each other, a systematic Medline/PubMed search for randomized, double blind studies on SGA in patients younger than 18years of age at enrolment, was conducted. Papers on schizophrenia, discussed in another article of this specific issue, were excluded by the efficacy analysis. A set of standard efficacy and safety indices, such as treatment effect sizes (ES), the Numbers Needed ...

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health research agency, NIMH is dedicated to reducing the burden of mental and behavioral disorders through research on mind, brain, and behavior. As part of that mission, NIMH...

UK PubMed Central (United Kingdom)

This paper reviews evidence for deficits in goal regulation in bipolar disorder. A series of authors have described mania as related to higher accomplishment, elevated achievement motivation,...Full Text Available

UK PubMed Central (United Kingdom)

In recent years increasing evidence is pointing toward white matter abnormalities in schizophrenia and other psychiatric disorders. The present paper will provide an overview over the role of...Full Text Available

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Abstract Copy number variants (CNVs) are known to be associated with complex neuropsychiatric disorders (e.g., schizophrenia and autism) but have not been explored in the isolated features of aggressive behaviors such as intermittent explosive disorder (IED). IED is characterized by recurrent episodes of aggression in which individuals act impulsively and grossly out of proportion from the involved stressors. Previous studies have identified genetic variants in the serotonergic pathway that play a role in susceptibility to this behavior, but additional contributors have not been identified. Therefore, to further delineate possible genetic influences, we investigated CNVs in individuals diagnosed with IED and/or personality disorder (PD). We carried out array comparative genomic hybridizati...

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... dipole moments magnetic fields monocrystals neutron diffraction order-disorder

International Nuclear Information System (INIS)

Full text: Disorders of brain development and phakomatosis are resulting from disturbed embryonic-foetal development One third of all major embryological anomalies involve CNS, and over 2000 different anomalies have been described. Anomalies of the brain often cause foetal and neonatal death, and mental and physical retardation in pediatric group. The majority of disorders of brain development and phakomatosis are idiopathic, and most of them are not hereditary or familial. Ultrasonography plays the important role in screening foetal and neonatal brain, but after closure of fontanels it is difficult to find the acoustic window. CT has limited contrast resolution, and disadvantage exposing infant to ionizing radiation. It is helpful to demonstrate the presence of calcifications. MR imaging has proved to be a diagnostic tool of major importance in children with disorders of brain development and phakomatosis. The excellent ...

UK PubMed Central (United Kingdom)

Diabetes mellitus is a metabolic disorder that leads to the development of a number of complications. The etiology of each diabetic complication is undoubtedly multifactorial. We will focus...Full Text Available

UK PubMed Central (United Kingdom)

Migraine is a common neurological disorder and can be severely disabling during attacks. The highest prevalence occurs between the ages of 25 and 55 years, potentially the most productive period...Full Text Available

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... Increased frequency of psychiatric/behavioral disorders, including aggressive behavior, seen in children treated with tolterodine. ...

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ObjectiveInjury is the leading cause of death among American youth, killing more 11-year-olds than all other causes combined. Children with symptoms of externalizing behavior disorders such as attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD) may have increased risk. Our aims were to determine: (1) whether increasing symptoms of ADHD and CD associate positively with injuries among a community sample of fifth graders; and (2) whether symptoms of ADHD and CD have a multiplicative rather than additive association with injuries among the sample. MethodsData were collected from 4745 fifth graders and their primary caregivers participating in Healthy Passages, a multisite, community-based study of pediatric health risk behaviors and health outcomes. The primary outcome wa...

International Nuclear Information System (INIS)

This work showed the formation of phospholipid vesicle coating on inorganic sericite surface with characterization by combining electron microscopy of FE-SEM, TEM, AFM, and qualitatively evaluated the coated phospholipid vesicle by XPS as a function of etching time. The possibility of phospholipid vesicle mobility on the surface was restrained by the chelation effect of magnesium cation. The stabilization properties of phospholipid vesicles on sericite surface were demonstrated by the various concentration of magnesium cation. The presence of magnesium was found to have a much more pronounced influence on the lipid deposition process. The Mg cation plays an important role for attaching the phospholipids with optimum concentration of 7 mM. Totally, the phospholipid vesicles coating on inorganic powder could be useful for bio-related fields such as cosmetics and drug delivery system as the key functional compounds. We hope ...

International Nuclear Information System (INIS)

In the present work the hydrogen desorption properties of nanostructured magnesium hydride (MgH2) synthesized by controlled reactive mechanical milling (CRMM) of elemental Mg powder under hydrogen are investigated. A profound effect of the particle size of synthesized MgH2 hydride on its hydrogen desorption characteristics measured by differential scanning calorimetery (DSC) has been found. All synthesized MgH2 powders are characterized by a double hydrogen desorption peak. Furthermore, below a certain threshold particle size the DSC desorption temperature of the peak doublet starts decreasing rapidly with decreasing of the mean hydride powder particle size (expressed as equivalent circle diameter-ECD). In contrast, the nanograin (crystallite) size of MgH2 does not seem to have apparent effect on the DSC desorption temperature. It is also observed that for powder particles smaller than some threshold value, X-ray diffraction shows the presence of two polymorphic ...

International Nuclear Information System (INIS)

In situ spectroscopic ellipsometry was employed to investigate the initial regime of rare earth metal (REM) conversion coatings formation on AZ31 magnesium alloy. Three REM salts solutions, 0.05 mol.dm"-"3 Ce(NO_3)_3, La(NO)_3 and Sm(NO)_3 solutions, were used for REM conversion coatings preparation. By deconvoluting the ellipsometric data, the surface of the fresh well-polished AZ31 magnesium alloy was found to be covered with 15.80 nm thick native (hydr)oxide film; the refractive indices and the thickness of Ce, La and Sm conversion coatings were obtained. The formation kinetics of three REM coatings follows different exponential functions and the coatings exhibit different optical properties. La conversion coating has the largest n values and the lowest k values while Sm conversion coating is just opposite. Moreover, the pH variation of the bulk conversion solutions upon the coatings formation was recorded. It is confirmed that the reduction ...

Energy Technology Data Exchange (ETDEWEB)

A press formability of magnesium alloy sheet cannot be evaluated by only general characteristics in tensile test; tensile strength, elongation n-value and r-value. For example, AZ31-alloy elongates about 20% in room temperature but breaks easily at shallow stage in deep drawing, which is caused by little local elongation (local necking). Crystallographic restriction of slip deformation in this alloy produces high strength, which almost equal to macroscopic fracture strength. In press forming, the bending under high tension requires a large deformability. A great difference in the deformability between AZ31 magnesium alloy and a strain hardened A1100 Aluminum (only 5% in elongation) is shown by static bending test with V-notch. In a rolled plate of AZ31, a crack is produced by stress concentration and propagates with reduced load at all testing temperature up to 453 K. In contrast, the point of notch in A1100 is dulled by local plastic ...

UK PubMed Central (United Kingdom)

Study DesignThis is a retrospective study that was done according to clinical and radiological evaluation.PurposeWe analyzed the clinical and radiological...Full Text Available

UK PubMed Central (United Kingdom)

The Clinical Summary is a Web-based application for accessing the clinical database at the Massachusetts General Hospital. The application has been developed to give physicians in our health care community...Full Text Available

UK PubMed Central (United Kingdom)

PURPOSE The Wells rule is widely used for clinical assessment of patients with suspected deep vein thrombosis (DVT), especially in the secondary care setting. Recently a new clinical decision...Full Text Available

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There are many factors affecting diffusion bonding in order to obtain high quality joining. Therefore, in the beginning, we constructed diffusion bonding model based on void growth mechanism to predict bonding pressures and times. In addition, in order to compare theoretical values with experimental values, diffusion bonding tests were carried out by using commercial AZ31 magnesium alloy sheets with different grain sizes, 16 and 130 {mu}m. The present AZ31 alloys were successfully diffusion bonded at several conditions, and the bonding strength was more than 0.8 of each parent materials. The experimental bonding conditions in high quality joining, times and pressures, were good agreed with prediction analysis. (orig.)

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This research investigated the inhibiting effects that sodium salts of linear monocarboxylic acids displayed towards the corrosion process of AZ31 Mg alloy in ASTM D 1387 saline solution (a synthetic industrial cooling water). The length of the aliphatic chain of the acids ranged between 7 and 15 carbon atoms. The inhibiting action of these salts can be related to the precipitation of an insoluble magnesium salt, which mainly affected the anodic reaction. The aliphatic chain length controlled the anion solubility and the reaction rate of magnesium carboxylate formation. For all the salts, an optimum concentration was experienced: 10{sup -2} M for sodium decanoate (caprate), 10{sup -3} M for sodium dodecanoate (laurate), 10{sup -4} M for sodium tetradecanoate (myristate); when this concentration was exceeded, a diminution (even a disappearance) in the inhibiting action was found. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

International Nuclear Information System (INIS)

Consideration is given to the data, demonstrating the effect of ion radiation on strength characteristics of ionic crystals, presented by magnesium oxide. Crystals, prepared in the form of plates, were irradiated by Si"+, Fe"+, C"+ ions by the dose of 10"1"6-10"1"7 ion/cm"2 at room temperature in vacuum. The following characteristics were investigated: dislocation density, microhardness, crack resistance. Investigation of dislocation structure showed, that dislocation density in irradiated sample was 2-3 times higher, as compared to nonirradiated one. Sufficient increase of fracture viscosity of MgO crystals was revealed. It can be conditioned by occurrence of compression stresses in the surface layer, decelerating crack formation and propagation.

Energy Technology Data Exchange (ETDEWEB)

Dynamic development of new grain boundaries was studied in compression of a magnesium alloy AZ31 with initial grain sizes (D{sub 0}) of 22 {mu}m and 90 {mu}m at a temperature of 673 K. Kink bands are evolved near corrugated grain boundaries and in grain interiors at low strains accompanied with new fine grains. Kink bands are developed often perpendicular to the basal plane. The boundary misorientation of kink band as well as the volume fraction of new grains increases rapidly with increasing strain and approaches a saturation value in high strain. New fine grains are developed faster with decrease in the D{sub 0}. It is concluded that new grain evolution is controlled by a deformation-induced continuous reaction, i.e. continuous dynamic recrystallization (DRX). (orig.)

International Nuclear Information System (INIS)

A method is described for determination of aluminium, cadmium, cobalt, chromium, copper, calcium, magnesium, sodium, potassium, manganese, nickel, lead, strontium, zinc, titanium and vanadium in iron ore. After dissolution, a 1 gram sample of iron ore is applied to a column of AGI-X8 anion exchange resin (chloride form), in 100 ml of 7M HCl. Aluminium, chromium, calcium, magnesium, sodium, potassium, manganese, nickel, lead, strontium, titanium and vanadium are eluted with 7M HCl; iron, copper and cobalt are eluted with 0.5M HCl; cadmium and zinc are eluted with 2M HNO_3. Iron is subsequently removed from copper and cobalt by a solvent extraction with methyl isobutyl ketone. The elements are determined in the eluates by atomic absorption spectrometry, except for titanium and vanadium, which are determined spectrophotometrically.

UK PubMed Central (United Kingdom)

A questionnaire on the development of specialist clinics was distributed to the members of the Association of British Neurologists and completed by 104 members (85 consultants). Half of the respondents...Full Text Available

UK PubMed Central (United Kingdom)

PURPOSE: To determine the risk factors and clinical signs of Curvularia keratitis and to evaluate the management and outcome of this corneal phaeohyphomycosis. METHODS: We reviewed clinical and laboratory...Full Text Available

UK PubMed Central (United Kingdom)

Although coagulase-negative staphylococci (C-NS) have been implicated in certain human infections, they are generally regarded as contaminants, and their clinical significance is questioned. To assess...Full Text Available

UK PubMed Central (United Kingdom)

Introduction: Generally agreed outcome criteria in psychosis are required to evaluate the effectiveness of new treatment strategies. The aim of this study is to explore clinical recovery...Full Text Available

UK PubMed Central (United Kingdom)

AIM: To evaluate the prevalence of upper gastrointestinal symptoms and their association with clinical and functional characteristics in elderly outpatients.METHODS: The study involved 3238 outpatients...Full Text Available

UK PubMed Central (United Kingdom)

A retrospective epidemiological study (n = 7,875) of neurologically expressed disorders (NED) in ruminants before the onset of the bovine spongiform encephalopathy epidemic...Full Text Available

International Nuclear Information System (INIS)

The possible existence of preferential B-site disorder in A-15 compounds recently claimed on the basis of x-ray powder diffraction data but questioned from the viewpoint of known phase diagrams is examined for some Nb-based compounds of this type. It is concluded that x-ray powder data do not allow the determination of both order and compositional variables as suggested, and the latter must therefore be determined by some other method. (author).

Energy Technology Data Exchange (ETDEWEB)

The aim of this thesis is to study the coherent transport in semiconducting-superconducting junctions. The SnPb-GaAs system has been studied. It has been shown that the behaviour of this junction is controlled by the disordered area induced by the annealing of the connection near the interface. For a few resistant junction, a conductance anomaly under the gap has been observed and has been explained by a mesoscopic effect in the limit of the very high disorders. The conductance of more resistant junctions has only been bound to the properties of the very disordered area of the semiconductor. The part of the electron-electron interactions on the phase coherence length and on the conductance has been studied. The evolving of the correction of the conductance due to interactions in magnetic field has been followed. The effect of the spin degeneration suppression in CdTe and the GaAs sign inversion in Shubnikov de Haas ...

International Nuclear Information System (INIS)

The separation, concentration, and determination of trace elements in iron ores are described. After the sample has been dissolved, the iron is separated by liquid-liquid extraction with a liquid cation-exchanger, di-(2-ethylhexyl) phosphoric acid. The trace elements aluminium, cadmium, calcium, chromium, cobalt, copper, lead, magnesium, manganese, mercury, potassium, sodium, vanadium, and zinc are determined in the aqueous phase by atomic-absorption spectrophotometry.

International Nuclear Information System (INIS)

The physical, chemical and mechanical properties of magnesium alloys make them attractive materials for automotive and aerospace applications. However, these materials are susceptible to corrosion and wear. This work discusses the potential of using sol-gel based coatings consisting of ZrO_2 and 15 wt.% of CeO_2. The CeO_2 component provides enhanced corrosion protection, while ZrO_2 impart corrosion as well as wear resistance. Coating deposition was performed by the dip coating technique on two magnesium alloy substrates with different surface finishes: AZ91D (as-casted, sand-blasted, and machined) and AZ31 (rolled and machined). All as-deposited coatings (xerogel coatings) were then subjected to 10 h annealing: a temperature of 180 C was applied to the AZ91D alloy and 140 C to the AZ31 alloy. Morphological and structural properties of the annealed coatings were investigated by scanning electron microscopy, atomic force microscopy and ...

Science.gov (United States)

A number of alloys of zirconium have been investigated as part of a program aimed at improving the high-temperature tensile and creep strength of zirconium. These alloys include aluminum, beryllium, lead, magnesium, molybdenum, niobium, tantalum, tin, titanium, tungsten, vanadium, and zinc, binary and ternary alloys. The data indicate that aluminum, lead, molybdenum niobium, tin, titanium, tungsten, and vanadium can be used successfully to harden zirconium, and that aluminum, tin, titanium, and vanadium are particularly effective in maintaining the strength of zirconium at elevated temperatures.

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Nutrient elements contained in litter fall flux, that of uptake flux and turnover rate had generally tended to increase with the increase in the Warmth Index, while the amount of nutrient in the A[sub 0] horizon and nutrient use efficiency did not. However, it is suggested that topographic and climatic aridity, and the amount of available and exchangeable phosphorus, calcium and magnesium greatly affect the nutrient dynamics in a each forest ecosystem as the Warmth Index increases. (J.P.N.).

International Nuclear Information System (INIS)

Dynamic recrystallization (DRX) is the main softening mechanism of magnesium alloy AZ31B in hot deformation. Theoretically, in the flow rule the atomic diffusibility and the driving force of dislocation migration are dependent on the temperature, and the dislocation density and the cumulation of grain boundary energy are dependent on the strain rate. The peak stress will appear when the flow driving force and resistance force reach a balance, after which the stress descending will take place due to recrystallization fraction. Since the DRX is a thermally activated process, the recrystallized volume fraction can be regarded as the function of strain through Avrami equation. Based on this idea, the paper proposes a new constitutive model characterizing dynamic recrystallization for magnesium alloy AZ31B. The model is described by a peak stress and a strain softening rate, in which the peak stress depends only on Zener-Hollomon parameter and is ...

Science.gov (United States)

PMID:20681969

Science.gov (United States)

PMID:21732206

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for municipal waste iron ore sinter plants incinerators for clinical waste facilities of the non-ferrous metal

KoreaScience (Korea)

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KoreaScience (Korea)

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KoreaScience (Korea)

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Science.gov (United States)

PMID:20091983

International Nuclear Information System (INIS)

Larsen syndrome is an autosomal-dominant disorder characterized by multiple joint dislocations, vertebral anomalies and dysmorphic facies. Both autosomal-dominant and autosomal-recessive forms of the disorder have been proposed. Individuals with autosomal-dominant Larsen syndrome have characteristic ''cylindrical-shape'' thumbs caused by broad, shortened phalanges. Autosomal-dominant Larsen syndrome results from heterozygosity for mutations in filamin B, a cytoskeletal protein involved in multicellular processes. We report here a patient with a duplicated or accessory distal thumb phalanx and multiple large joint dislocations who was shown to be heterozygous for a filamin B mutation predicting the amino acid substitution G1691S. This adds a new radiographic finding, duplicated or accessory distal phalanx, to the radiographic abnormalities seen in this rare dominant disorder. (orig.)

International Nuclear Information System (INIS)

The universal depression of the superconducting transition temperature T/sub c/ in disordered A-15 compounds is examined. It is found that their anomalous behavior can be explained by a simple model for the density of states, which is enhanced by disorder in some cases. The dramatic drop in T/sub c/ in constant density-of-states A-15 compounds like Nb_3Ge or Nb_3Al at a critical value of the resistivity can be attributed to overdamping of acoustic plasmons, which decreases the electron pairing interaction despite relatively small changes in the density of states. Agreement for T/sub c/ and susceptibility chi with previous calculations is found of the position of the Fermi energy is near a peak. Possible experiments are proposed to check the above models.

British Library Electronic Table of Contents (United Kingdom)

Background:- Children with oppositional defiant disorder/conduct disorder (ODD/CD) have shown deficits in -cool- abstract-cognitive, and -hot- reward-related executive function (EF) tasks. However, it is currently unclear to what extent ODD/CD is associated with neuropsychological deficits, independently of attention deficit hyperactivity disorder (ADHD). Methods:- Fifty-nine adolescents with a history of early-onset oppositional problems, 28 with pure ODD/CD symptoms and 31 with ADHD with or without ODD/CD, and 34 healthy controls were administered a task battery measuring motor response inhibition, sustained attention, cognitive flexibility and reward-related decision-making. Findings were analysed using dimensional and group analyses. Results:- In group analyses both groups with and wit...

Energy Technology Data Exchange (ETDEWEB)

Functional imaging of the pharynx used to be the domain of cineradiography, CT and ultrafast CT. The development of modern MRI techniques led to new access to functional disorders of the pharynx. The aim of this study was to implement a new MRI technique to examine oropharyngeal obstructive mechanisms in patients with obstructive sleep apnea (OSA). Sixteen patients suffering from OSA and 6 healthy volunteers were examined on a 1.5 T whole-body imager (`Vision`, Siemens, Erlangen Medical Engineering, Germany) using a circular polarized head coil. Imaging was performed with 2D flash sequences in midsagittal and axial planes. Patients and volunteers were asked to breathe normally through the nose and to simulate snoring and the Mueller maneuver during magnetic resonance imaging (MRI). Prior to MRI, all patients underwent an ear, nose and throat (ENT) examination, functional fiberoptic nasopharyngoscopy and polysomnography. A temporal resolution of 6 images/s and an ...

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...5 kg or less) to less than 10 percent; (c) Reduction of iron deficiency anemia in women by one-third of the 1990 levels; (d) Virtual elimination of iodine deficiency disorders; (e) Virtual elimination of vitamin A deficiency and its consequences, including blindness; (...

UK PubMed Central (United Kingdom)

BackgroundEpilepsy is a common neurological disorder characterized by recurrent electrophysiological activities, known as seizures. Without the appropriate detection strategies,...Full Text Available

UK PubMed Central (United Kingdom)

Ophthalmologic abnormalities have been described in patients with dementia, but the extent to which poor vision and treatment for visual disorders affect cognitive decline is not well defined. Linked...Full Text Available

UK PubMed Central (United Kingdom)

ObjectivesUse of prescription opioids for chronic pain is increasing, as is abuse of these medications, though the nature of the link between these trends is unclear....Full Text Available

UK PubMed Central (United Kingdom)

This study examined changes in the degree of positive bias in self-perceptions of previously-diagnosed 8 to 13 year-old children with attention-deficit/hyperactivity disorder (ADHD) (n=513)...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundOne of the more common behavioral manifestations of dementia-related disorders is severe problems with out-of-home mobility. Various efforts have been attempted to attain...Full Text Available

UK PubMed Central (United Kingdom)

Thus far there are relatively few data on the risk of leukemia among those who were exposed to external radiation during cleanup operations following the Chornobyl nuclear accident, and results...Full Text Available

UK PubMed Central (United Kingdom)

Patient-centered interdisciplinary health care for children with chronic medical disorders represents an evolution from the traditional “stop and go” treatment for acute illnesses. This...Full Text Available

UK PubMed Central (United Kingdom)

Skeletal muscle uses calcium as a second messenger to respond and adapt to environmental stimuli. Elevations in intracellular calcium levels activate calcineurin, a serine/threonine phosphatase, resulting...Full Text Available

UK PubMed Central (United Kingdom)

Interactions between presynaptic and postsynaptic cellular adhesion molecules (CAMs) drive synapse maturation during development. These trans-synaptic interactions are regulated by alternative splicing...Full Text Available

UK PubMed Central (United Kingdom)

Disorders of mitochondrial fat metabolism lead to sudden death in infants and children. Although survival is possible, the underlying molecular mechanisms which enable this outcome have not yet been...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Types of disorders in the earth's surface as a result of open pit mining operations are analyzed. Trends for recultivation of lands are defined. Formulas are presented for calculating the economic expediency of the selected direction of recultivation.

UK PubMed Central (United Kingdom)

The etiology of major depression remains unknown, but dysfunction of serotonergic signaling has long been implicated in the pathophysiology of this disorder. p11 is an S100 family member recently...Full Text Available

UK PubMed Central (United Kingdom)

ObjectiveThis study assessed the relationship between multiple indicators of ‘real-world’ functioning and scores on a brief performance-based measure...Full Text Available

UK PubMed Central (United Kingdom)

Convection-enhanced delivery (CED) has emerged as a promising method of targeted drug-delivery for treating central nervous system (CNS) disorders, but the influence of brain structure on infusate...Full Text Available

UK PubMed Central (United Kingdom)

Genomic disorders are conditions that result from DNA rearrangements, such as deletions or duplications. The identification of the dosage-sensitive gene(s) within the rearranged genomic interval is...Full Text Available

UK PubMed Central (United Kingdom)

The past decade has seen rapid advances in the identification of associations between candidate genes and a range of common multifactorial disorders. This paper evaluates public attitudes towards the...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe aim of this double-blind randomized study is to test the efficacy of a radio electric stimulator device using an auricular reflex therapy protocol for stress-related...Full Text Available

UK PubMed Central (United Kingdom)

Haemophilia, the commonest hereditary bleeding disorder, arises because of the absence of, decrease in, or deficient functioning of plasma coagulation factor VIII or factor IX. With rare exceptions,...Full Text Available

UK PubMed Central (United Kingdom)

Giant paraesophageal hernia is an uncommon morbid disorder which may present a risk of catastrophic complications and should be repaired electively as soon as possible. Laparoscopic fundoplication is...Full Text Available

UK PubMed Central (United Kingdom)

ObjectiveThe primary objective of this study was to assess whether pentagastrin-induced panic symptoms are associated with release of free fatty acids (FFAs) in a manner that could...Full Text Available

UK PubMed Central (United Kingdom)

Phenylketonuria (PKU) is a common genetic disorder in humans that arises from deficient activity of phenylalanine hydroxylase (PAH), which catalyzes the conversion of phenylalanine to tyrosine....Full Text Available

UK PubMed Central (United Kingdom)

BackgroundMutations that impair mitochondrial functioning are associated with a variety of metabolic and age-related disorders. A barrier to rigorous tests of the role of mitochondrial...Full Text Available

UK PubMed Central (United Kingdom)

This paper presents the results of a meta-analysis for a single investigator examining the effectiveness of the modified therapeutic community (MTC) for clients with co-occurring substance use...Full Text Available

UK PubMed Central (United Kingdom)

Muscular dystrophies (MDs) comprise a group of degenerative muscle disorders characterized by progressive muscle wasting and often premature death. The primary defect common to most MDs involves disruption...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe aim of this study was to investigate the mental health status, and the risk factors associated with mild psychiatric disorders, of female foreign spouses (from Vietnam,...Full Text Available

UK PubMed Central (United Kingdom)

Mutations in SPTBN2, the gene encoding β-III spectrin, cause spinocerebellar ataxia type 5 in humans (SCA5), a neurodegenerative disorder resulting in loss of motor...Full Text Available

UK PubMed Central (United Kingdom)

Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are mediated by cytokines and their receptors. Studies conducted over the past 10 to 15 years have revealed that...Full Text Available