macrurus myogenic regulatory: Topics by WorldWideScience.org

Unraveling gene regulatory networks from time-resolved gene expression data -- a measures comparison study

The Atomic Energy commission of Syria (AECS) is nominated by Syrian legislation as the regulatory authority in respect of radiation protection and safety and security of radioactive sources. In addition AECS is providing a wide range of Technical Services (TS) through its various departments. In this paper, the cooperation and coordination between the regulatory authority and the providers of technical services in Syria are described. The adjustment of the regulatory programme as to make maximal use of the available technical resources is presented. It was shown that this relationship does not jeopardize the effective independency of the regulatory authority which is maintained by keeping the regulatory decisions based on pure regulatory considerations. (author)

2007-08-01

5

Application of Resource Portfolio Concept in Nuclear Regulatory Infrastructure Support

BackgroundInferring regulatory interactions between genes from transcriptomics time-resolved data, yielding reverse engineered gene regulatory networks, is of paramount importance...Full Text Available

6

Regulatory T cells in human disease and their potential for therapeutic manipulation

As the new entrants in the global nuclear construction market are increasing and the establishment of an effective and sustainable regulatory infrastructure becomes more important, they have requested international assistance from the international nuclear communities with mature nuclear regulatory programmes. It needs to optimize the use of limited resources from regulatory organization providing support to regulatory infrastructure of new comers. This paper suggests the resource portfolio concept like a GE/Mckinsey Matrix used in business management and tries to apply it to the current needs considered in the regulatory support program in Korea as the case study

2010-10-01

7

Cis-regulatory mutations in human disease

Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory...Full Text Available

2006-05-01

8

The Enzymatic Regulatory Effects of Laninaria japonica Fucoidan Extract in Hepatotoxicity

Cis-acting regulatory sequences are required for the proper temporal and spatial control of gene expression. Variation in gene expression is highly heritable and a significant determinant...Full Text Available

2009-07-01

9

KoreaScience (Korea)

Full Text Available

2006-12-01

10

NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit

Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing

No abstract prepared.

2006-12-15

11

Annual Report 2007. Nuclear Regulatory Authority

No abstract prepared.

2001-04-01

12

Large Scale Laser Two-Photon Polymerization Structuring for Fabrication of Artificial Polymeric Scaffolds for Regenerative Medicine

The present Annual Report of Activities of the Nuclear Regulatory Authority (ARN), prepared regularly from the creation as independent institution, describes across tree parts and seven annexes the activities developed by the organism during 2007. The main topic are: the organization and the activity of the ARN; the regulatory standards; the licensing and inspection of nuclear power plants and critical facilities; the emergency systems; the occupational surveillance; the environmental monitoring; improved organizational. Also, this publication have annexes with the following content: regulatory documents; inspections to medical, industrial and training installations; regulatory guides; measurement and evaluation of the drinking water of Ezeiza.

2004-07-11

13

The frequency of CD25+CD4+ and FOXP3+ regulatory T cells in ectopic endometrium and ectopic decidua

We present a femtosecond Laser Two-Photon Polymerization (LTPP) system of large scale three-dimensional structuring for applications in tissue engineering. The direct laser writing system enables fabrication of artificial polymeric scaffolds over a large area (up to cm in lateral size) with sub-micrometer resolution which could find practical applications in biomedicine and surgery. Yb:KGW femtosecond laser oscillator (Pharos, Light Conversion. Co. Ltd.) is used as an irradiation source (75 fs, 515 nm (frequency doubled), 80 MHz). The sample is mounted on wide range linear motor driven stages having 10 nm sample positioning resolution (XY--ALS130-100, Z--ALS130-50, Aerotech, Inc.). These stages guarantee an overall travelling range of 100 mm into X and Y directions and 50 mm in Z direction and support the linear scanning speed up to 300 mm/s. By moving the sample three-dimensionally the position of laser focus in the photopolymer is changed and one is able to write complex 3D ...

2010-11-10

14

Technical support of regulatory authority in Ukraine

BackgroundThe presence of regulatory T (Treg) cells in human endometrium is crucial for maintaining immunological homeostasis within the uterus. For this study we decided to evaluate...Full Text Available

15

Reverse Engineering of Gene Regulatory Networks: A Comparative Study

Main results of 15-year SSTC NRS activity in the field of technical support of regulatory authority are presented. The article also described management policy, quality assurance system, personnel training system and international co-operation of SSTC. (author)

2007-08-01

16

Regulatory T Cells in Many Flavors Control Asthma

Reverse engineering of gene regulatory networks has been an intensively studied topic in bioinformatics since it constitutes an intermediate step from explorative to causative gene expression...Full Text Available

2009-01-01

17

Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity

That regulatory T cells (Tregs) have a crucial role in controlling allergic diseases such as asthma is now undisputed. The cytokines most commonly implicated in Treg-mediated suppression of...Full Text Available

2010-05-01

18

Multilevel support vector regression analysis to identify condition-specific regulatory networks

How transcription factors interpret the cis-regulatory logic encoded within enhancers to mediate quantitative changes in spatiotemporally restricted expression patterns during animal...Full Text Available

2010-05-15

19

Mapping cis-Regulatory Domains in the Human Genome UsingMulti-Species Conservation of Synteny

Motivation: The identification of gene regulatory modules is an important yet challenging problem in computational biology. While many computational methods have been proposed to identify...Full Text Available

2010-06-01

20

Localizing potentially active post-transcriptional regulations in the Ewing's sarcoma gene regulatory network

Our inability to associate distant regulatory elements with the genes that they regulate has largely precluded their examination for sequence alterations contributing to human disease. One major obstacle is the large genomic space surrounding targeted genes in which such elements could potentially reside. In order to delineate gene regulatory boundaries we used whole-genome human-mouse-chicken (HMC) and human-mouse-frog (HMF) multiple alignments to compile conserved blocks of synteny (CBS), under the hypothesis that these blocks have been kept intact throughout evolution at least in part by the requirement of regulatory elements to stay linked to the genes that they regulate. A total of 2,116 and 1,942 CBS>200 kb were assembled for HMC and HMF respectively, encompassing 1.53 and 0.86 Gb of human sequence. To support the existence of complex long-range regulatory domains within these CBS we ...

2005-06-13

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

21

Efficient discovery of ASCL1 regulatory sequences through transgene pooling

BackgroundA wide range of techniques is now available for analyzing regulatory networks. Nonetheless, most of these techniques fail to interpret large-scale transcriptional data...Full Text Available

22

Cost-Effectiveness Analysis of Proposed Effluent Limitations Guidelines and Standards for the Pesticide Manufacturing Industry.

Zebrafish transgenesis is a powerful and increasingly common strategy to assay vertebrate transcriptional regulatory control. Several challenges remain, however, to the broader application of...Full Text Available

2010-06-01

23

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

The report analyzes the cost-effectiveness of two alternative regulatory options: A Treated Discharge Option and a Zero Discharge Option. The report compares the total annualized cost incurred for each of the two regulatory options to the corresponding ef...

1992-01-01

24

Regulation of the expression of the apolipoprotein(a) gene : Evidence for a regulatory role of the 5' distal ACR enhancer in YAC transgenic mice

Cellular cholesterol homeostasis is controlled by sterol-regulated proteolysis of membrane-bound transcription factors called sterol-regulatory element binding proteins (SREBPs). CPP32, a cysteine protease,...Full Text Available

1996-03-01

25

Quality assurance requirements for the design of nuclear power plants

No abstract prepared.

2003-01-30

26

Quality assurance requirements for control of procurement of items and services for nuclear power plants

Oct 1973. 1 p. United States USAEC Directorate of Regulatory Standards,

27

PRA QUALITY IN REGULATORY DECISIONS

Oct 1976. 2 p. United States Nuclear Regulatory Commission, Washington,

28

North Quabbin MA Timber Harvesting Study

ASME PRA STANDARD FOR PRA. FOR NPP APPLICATION. " Provides a Standard for performing and using a. PRA. Definitions. Risk assessment ...

29

Polyunsaturated Fatty Acids Selectively Suppress Sterol Regulatory Element-binding Protein-1 through Proteolytic Processing and Autoloop Regulatory Circuit*

... this critical information, we analyzed 17 years of timber harvest data gathered for regulatory purposes for a ... ...

30

Complementation of areA- regulatory gene mutations of Aspergillus nidulans by the heterologous regulatory gene nit-2 of Neurospora crassa.

Sterol regulatory element-binding protein (SREBP)-1 is a key transcription factor for the regulation of lipogenic enzyme genes in the liver. Polyunsaturated fatty acids (PUFA) selectively suppress hepatic...Full Text Available

2010-04-09

31

Recommendations for a proposed standard for performing systems analysis

Loss-of-function mutations in the regulatory gene areA of Aspergillus nidulans prevent the utilization of a wide variety of nitrogen sources. The phenotypes of nit-2 mutants of Neurospora crassa suggest...Full Text Available

1987-06-01

32

Recommendations for a proposed standard for performing systems analysis

In August 1995, the Nuclear Regulatory Commission (NRC) issued a policy statement proposing improved regulatory decisionmaking by increasing the use of PRA [probabilistic risk assessment] in all regulatory matters to the extent supported by the state-of-the-art in PRA methods and data. A key aspect in using PRA in risk-informed regulatory activities is establishing the appropriate scope and attributes of the PRA. In this regard, ASME decided to develop a consensus PRA Standard. The objective is to develop a PRA Standard such that the technical quality of nuclear plant PRAs will be sufficient to support risk-informed regulatory applications. This paper presents examples recommendations for the systems analysis element of a PRA for incorporation into the ASME PRA Standard.

1998-08-01

33

NRC safety research in support of regulation, FY 1992. Volume 7

In August 1995, the US Nuclear Regulatory Commission (NRC) issued a policy statement proposing improved regulatory decision making by increasing the use of probabilistic risk assessment (PRA) in all regulatory matters to the extent supported by the state-of-the-art in PRA methods and data. A key aspect in using PRA in risk-informed regulatory activities is establishing the appropriate scope and attributes of the PRA. In this regard, the American Society of Mechanical Engineers (ASME) decided to develop a consensus PRA standard. The objective is to develop a PRA standard such that the technical quality of nuclear plant PRAs will be sufficient to support risk-informed regulatory applications. The authors present example recommendations for the systems analysis element of a PRA for incorporation into the ASME PRA standard.

1998-12-31

34

NRC safety research in support of regulation, FY 1992

This report, the eighth in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1992. A special emphasis on accomplishments in nuclear power plant aging research reflects recognition that a number of plants are entering the final portion of their original 40-year operating licenses and that, in addition to current aging effects, a focus on safety considerations for license renewal becomes timely. The primary purpose of performing regulatory research is to develop and provide the Commission and its staff with the technical bases for regulatory decisions on the safe operation of licensed nuclear reactors and facilities, to find unknown or unexpected safety problems, and to develop data and related information for the purpose of revising the ...

1993-05-01

35

NRC safety research in support of regulation--FY 1989

This report, the eighth in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1992. A special emphasis on accomplishments in nuclear power plant aging research reflects recognition that a number of plants are entering the final portion of their original 40-year operating licenses and that, in addition to current aging effects, a focus on safety considerations for license renewal becomes timely. The primary purpose of performing regulatory research is to develop and provide the Commission and its staff with the technical bases for regulatory decisions on the safe operation of licensed nuclear reactors and facilities, to find unknown or unexpected safety problems, and to develop data and related information for the purpose of revising the ...

1993-05-01

36

NRC safety research in support of regulation, FY 1991. Volume 6

This report, the fifth in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1989. The goal of this office is to ensure that safety-related research provides the technical bases for rulemaking and for related decisions in support of NRC licensing and inspection activities. This research is necessary to make certain that the regulations that are imposed on licensees provide an adequate margin of safety so as to protect the health and safety of the public. This report describes both the direct contributions to scientific and technical knowledge with regard to nuclear safety and their regulatory applications.

1990-04-01

37

NRC safety research in support of regulation, FY 1991

This report, the seventh in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1991. The goal of this office is to ensure that safety-related research provides the technical bases for rulemaking and for related decisions in support of NRC licensing and inspection activities. This research is necessary to make certain that the regulations that are imposed on licensees provide an adequate margin of safety so as to protect the health and safety of the public. This report describes both the direct contributions to scientific and technical knowledge with regard to nuclear safety and their regulatory applications.

1992-04-01

38

NRC safety research in support of regulation, FY 1990

This report, the seventh in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1991. The goal of this office is to ensure that safety-related research provides the technical bases for rulemaking and for related decisions in support of NRC licensing and inspection activities. This research is necessary to make certain that the regulations that are imposed on licensees provide an adequate margin of safety so as to protect the health and safety of the public. This report describes both the direct contributions to scientific and technical knowledge with regard to nuclear safety and their regulatory applications.

1992-04-01

39

NRC safety research in support of regulation, 1988

This report, the sixth in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1990. The goal of this office is to ensure that safety-related research provides the technical bases for rulemaking and for related decisions in support of NRC licensing and inspection activities. This research is necessary to make certain that the regulations that are imposed on licensees provide an adequate margin of safety so as to protect the health and safety of the public. This report describes both the direct contributions to scientific and technical knowledge with regard to nuclear safety and their regulatory applications.

1991-04-01

40

NRC safety research in support of regulation, 1986

This report, the fourth in a series of annual reports, was prepared in response to Congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during 1988. The goal of this office is to ensure that safety-related research provides the technical bases for rulemaking and for related decisions in support of NRC licensing and inspection activities. This research is necessary to make certain that the regulations that are imposed on licensees provide an adequate margin of safety so as to protect the health and safety of the public. This report describes both the direct contributions to scientific and technical knowledge with regard to nuclear safety and their regulatory applications.

1989-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

41

This report is the second in a series of annual reports responding to congressional inquiries as to the utilization of nuclear regulatory research. NUREG-1175, ''NRC Safety Research in Support of Regulation,'' published in May 1986, reported major research accomplishments between about FY 1980 and FY 1985. This report narrates the accomplishments of FY 1986 and does not restate earlier accomplishments. Earlier research results are mentioned in the context of current results in the interest of continuity. Both the direct contributions to scientific and technical knowledge and their regulatory applications, when there has been a definite regulatory outcome during FY 1986, have been described.

1987-09-01

42

Controlling the atom

Small Regulatory RNA and Legionella pneumophila

The authors trace the early history of nuclear power regulation in the US. Focusing on the Atomic Energy Commission, they describe the role of other groups that figured in the development of regulatory policies, including the Congressional Joint Committee on Atomic Energy, other federal agencies, state governments, the nuclear industry, and scientific organizations. They consider changes in public perceptions of and attitudes toward atomic energy and the dangers of radiation exposure. The basic purpose of the book is to provide the Nuclear Regulatory Commission and the general public with information on the historical antecedents and background of regulatory issues so that there will be continuity in policy decisions. The book concludes with an annotated bibliography of selected references. 19 figures.

1984-01-01

43

Refilling Intracellular Calcium Stores

Legionella pneumophila is a gram-negative bacterial species that is ubiquitous in almost any aqueous environment. It is the agent of Legionnaires’ disease, an acute and often...Full Text Available

44

Quality assurance requirements for protective coatings applied to water-cooled nuclear power plants

Within the cardiac cell, the movements of calcium ions are tightly regulated by a number of regulatory proteins including pumps, and channels. The sarcoplasmic reticulum (SR) is in large part...Full Text Available

2010-01-01

45

Jun 1973. 2 p. United States USAEC Directorate of Regulatory Standards,

46

FR Doc 2010-24310

A Perspective into Regulatory Requirements for Intentional Aircraft Crash

and used to reduce or replace petroleum-based transportation fuel, heating oil or jet fuel). In addition, this rule includes a new regulatory provision establishing a...

2010-09-27

47

Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm

In the aftermath of the 9/11 terrorist attacks on the United States, there was heightened interest worldwide in protecting nuclear power plants against intentional aircraft attack by terrorists. This paper presents our perspective into regulatory requirements for intentional aircraft crash that were set forth in foreign countries, including the latest rulemaking by the U.S. Nuclear Regulatory Commission (NRC), i.e., 10 CFR 50.54(hh) and 10 CFR 50.150 that have been made effective in May and July of 2009, respectively. In light of these international efforts to further enhance safety of NPPs, a study is also underway at the Korea Institute of Nuclear Safety (KINS) to establish an effective and efficient regulatory approach in consideration of the state of the art in this area

2010-10-01

48

Signal transduction pathway controlling synthesis of a class of degradative enzymes in Bacillus subtilis: expression of the regulatory genes and analysis of mutations in degS and degU.

In the early 1970s a spate of papers by research groups around the world provided evidence for a negative regulatory role of thymus-derived lymphocytes (T cells). In 1971, Gershon and Kondo published...Full Text Available

2008-01-01

49

Review and evaluation of the Nuclear Regulatory Commission safety research program for Fiscal Year 1983. Report to the Congress

The rates of synthesis of a class of both secreted and intracellular degradative enzymes in Bacillus subtilis are controlled by a signal transduction pathway defined by at least four regulatory genes:...Full Text Available

1990-02-01

50

Review and evaluation of the Nuclear Regulatory Commission safety research program for Fiscal Year 1982. Report to the Congress

Public Law 95-209 includes a requirement that the Advisory Committee on Reactor Safeguards submit an annual report to Congress on the safety research program of the Nuclear Regulatory Commission. This report presents the results of the ACRS review and evaluation of the NRC safety research program for Fiscal Year 1983. The report contains a number of comments and recommendations.

1982-02-01

51

Research and information needs for management of oil shale development

Public Law 95-209 includes a requirement that the Advisory Committee on Reactor Safeguards submit an annual report to Congress on the safety research program of the Nuclear Regulatory Commission. This report presents the results of the ACRS review and evaluation of the NRC safety research program for Fiscal Year 1982. The report contains a number of comments and recommendations.

1981-02-01

52

Regulatory T cells inhibit stable contacts between CD4⁺ T cells and dendritic cells in vivo

This report presents information and analysis to assist BLM in clarifying oil shale research needs. It provides technical guidance on research needs in support of their regulatory responsibilities for onshore mineral activities involving oil shale. It provides an assessment of research needed to support the regulatory and managerial role of the BLM as well as others involved in the development of oil shale resources on public and Indian lands in the western United States.

1983-05-01

53

Proceedings of the tenth annual DOE low-level waste management conference: Session 1: Institutional and regulatory issues

Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that,...Full Text Available

2006-03-20

54

Developing a regulatory performance assessment approach for geological disposal of spent nuclear fuel

This document contains eleven papers on various aspects of low-level radioactive waste regulation. Topics include: EPA environmental standards; international exemption principles; the concept of below regulatory concern; envirocare activities in Utah; mixed waste; FUSRAP and the Superfund; and a review of various incentive programs. Individual papers are processed separately for the data base. (TEM)

1988-12-01

55

Competition between small business and rural electic and telephone cooperatives in nonutility business. Final report

To be able to carry out review functions regulatory authorities must be able to make critical evaluations of proponent's safety cases. In Sweden the Swedish Radiation Safety Authority aims to have in place its own suite of performance assessment tools. This paper looks at the role and application of a regulator's models to important features of current modelling in a proponent's performance assessment. (authors)

56

Comparative analysis of the ATRX promoter and 5' regulatory region reveals conserved regulatory elements which are linked to roles in neurodevelopment, alpha-globin regulation and testicular function

The study concludes that while the diversification into nonutility activities by the Rural Electric Cooperatives and the Rural Telephone Cooperatives has been expanding, the regulatory activities by the Rural Electrification Administration and the state public utility commissions have been inadequate to guard against cross-subsidization. In fact, there generally exist no data to identify and investigate illegal cross-subsidization activities of cooperatives. Increasing the regulatory functions of state public utility commissions and the REA was recommended.

1989-05-01

57

Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states¹²³

BackgroundATRX is a tightly-regulated multifunctional protein with crucial roles in mammalian development. Mutations in the ATRX gene cause ATR-X syndrome, an X-linked...Full Text Available

58

Leak-Before-Break: Further developments in regulatory policies and supporting research

Background: Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR)...Full Text Available

2009-01-01

59

A study on the relevance and influence of the existing regulation and risk informed/performance based regulation

The fourth in a series of international Leak-Before-Break (LBB) Seminars supported in part by the US Nuclear Regulatory Commission was held at the National Central Library in Taipei, Taiwan on May 11 and 12, 1989. The seminar updated the international polices and supporting research on LBB. Attendees included representatives from regulatory agencies, electric utilities, nuclear power plant fabricators, research organizations, and academic institutions. Regulatory policy was the subject of presentations by Mr. G. Arlotto (US NRC, USA) Dr. B. Jarman (AECB, Canada), Dr.P. Milella (ENEA-DISP, Italy), Dr. C. Faidy (EDF/Septen, France ), and Dr. K. Takumi (NUPEC, Japan). A paper by Mr. K. Wichman and Mr. A. Lee of the US NRC Office of Nuclear Reactor Regulation is included as background material to these proceedings; it discusses the history and status of LBB applications in US nuclear power plants. In addition, several papers on ...

1990-02-01

60

Role of regulatory T cell populations in controlling graft vs host disease

The goal of this study is to estimate the relevance and Influence of the Existing Regulation and the RI-PBR to the institutionalization of the regulatory system. This study reviews the current regulatory system and the status of the RI-PBR implementation of the US NRC and Korea based upon SECY Papers, Risk Informed Regulation Implementation Plan (RIRIP) of the US NRC and other domestic studies. In order to investigate the perceptions, knowledge level, ground for the regulatory change, a survey was performed to Korean nuclear utilities, researchers and regulators on the perception on the RIR. The questionnaire was composed of 50 questions regarding personal details on work experience, level of education and specific field of work ; level of knowledge on the risk informed performance based regulation (RI-PBR); the perception of the current regulation, the effectiveness, level of procedure, flexibility, dependency on the ...

2003-02-15

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61

British Library Electronic Table of Contents (United Kingdom)

Immune function is critical in health and disease. The control and regulation of immune reactions is an area of intense investigation that has important implications for allogeneic hematopoietic cell transplantation. Immune reactions are regulated in a number of important ways. Compartmentalization of immune responses and the production of both pro-inflammatory and anti-inflammatory cytokines play a major role. More recently several populations of T cells that regulate immune responses termed regulatory T cells have been identified. This manuscript will focus on CD4^+CD25^+FoxP3^+ natural regulatory T cells (T"r"e"g) and @a@bTCR^+CD4^+NK1.1^+ natural killer T (NK-T) cells which both suppress graft vs host disease but appear to function by distinct mechanisms.

2011-01-01

62

Lessons learned from accidents in industrial radiography

Changes in regulatory theory: Market-based pricing

Industrial radiography accounts for approximately half of all the reported accidents for the nuclear related industry, in both developed and developing countries. This Safety Report is the result of a review made of a large selection of accidents in industrial radiography reported by regulatory authorities, professional associations and scientific journals. A small, representative selection of 43 accident descriptions has been used to illustrate the primary causes of radiography accidents, and a set of measures provided to prevent the recurrence of such accidents or to mitigate the consequences of those that do occur. These accident descriptions were categorized by primary causes as follows: inadequate regulatory control; failure to follow operational procedures; inadequate training; inadequate maintenance; human error; equipment malfunction or defect; design flaws; and wilful violation. The information in this Safety report is intended for use ...

63

Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis

With the introduction of competition and diversification into retail utility services, rate-making methods are being rethought. Rates that are strictly cost-based may be too slow in responding to changes within the utility industry. And the advent of independent power production as a significant source of energy calls for greater flexibility in pricing of wholesale utility services as well. Various deregulation or reregulation plans have been formulated, including both price cap and price floor proposals. Some regulatory authorities have embraced market-based pricing over cost-based methods as the best solution to pricing problems. This article addresses Federal Energy Regulatory Commission response to market-based rates.

1990-11-08

64

Using Regulatory and Epistatic Networks to Extend the Findings of a Genome Scan: Identifying the Gene Drivers of Pigmentation in Merino Sheep

Wiskott-Aldrich syndrome protein (WASp) is essential for optimal T cell activation. Patients with WAS exhibit both immunodeficiency and a marked susceptibility to systemic autoimmunity. We investigated...Full Text Available

2007-02-01

65

Tumour-stromal interactions: Phenotypic and genetic alterations in mammary stroma - implications for tumour progression

Extending genome wide association analysis by the inclusion of gene expression data may assist in the dissection of complex traits. We examined piebald, a pigmentation phenotype in both human and Merino...Full Text Available

66

Transposons as tools for enhancer trap screens in vertebrates

In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in...Full Text Available

2001-01-01

67

Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning

DNA transposons are efficient tools in transgenesis and have therefore become popular in the analysis of the regulatory genome in vertebrates via enhancer trap screens. Here, I discuss recent progress...Full Text Available

2007-01-01

68

Tight linkage of glnA and a putative regulatory gene in Rhizobium leguminosarum.

Memory consolidation requires transcription and translation of new protein. Arc, an effector immediate early gene, and zif268, a regulatory transcription factor, have been implicated in synaptic plasticity...Full Text Available

2010-01-01

69

The RNA Chaperone Hfq Is Important for Growth and Stress Tolerance in Francisella novicida

Rhizobium leguminosarum, biovar viceae, strain RCC1001 contains two glutamine synthetase activities, GSI and GSII. We report here the identification of glnA, the structural gene for GSI. A 2 kb fragment...Full Text Available

1987-03-11

70

Sp1/NF?B/HDAC/miR-29b Regulatory Network in KIT-driven Myeloid Leukemia

The RNA-binding protein Hfq is recognized as an important regulatory factor in a variety of cellular processes, including stress resistance and pathogenesis. Hfq has been shown in several bacteria to...Full Text Available

71

Serum Prohepcidin Levels in Helicobacter Pylori Infected Patients with Iron Deficiency Anemia

SUMMARYThe biologic and clinical significance of KIT overexpression that associates with KIT gain-of- function mutations occurring in subsets...Full Text Available

2010-04-13

72

Sequence features that drive human promoter function and tissue specificity

Background/AimsHelicobacter pylori (H. pylori) infection appears to subvert the human iron regulatory mechanism and thus upregulates hepcidin, resulting...Full Text Available

2010-06-01

73

Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits.

Promoters are important regulatory elements that contain the necessary sequence features for cells to initiate transcription. To functionally characterize a large set of human promoters, we measured...Full Text Available

2010-07-01

74

Role of the nac gene product in the nitrogen regulation of some NTR-regulated operons of Klebsiella aerogenes.

A regulatory locus on the Staphylococcus aureus chromosome, designated sar, is involved in the expression of cell wall proteins, some of which are potentially important in the pathogenesis of endocarditis....Full Text Available

1994-05-01

75

Repressive BMP2 Gene Regulatory Elements Near the BMP2 promoter

A positive, genetic selection against the activity of the nitrogen regulatory (NTR) system was used to isolate insertion mutations affecting nitrogen regulation in Klebsiella aerogenes. Two classes...Full Text Available

1990-12-01

76

Regulatory compliance | Mott MacDonald

The level of bone morphogenetic protein 2 (BMP2) profoundly influences essential cell behaviors such as proliferation, differentiation, apoptosis, and migration. The spatial and temporal pattern...Full Text Available

2010-02-05

77

Wastenet

...broad range of experience in designing and building research and development laboratories for products such as vaccines, blood and sera, biological products, medical devices, solid dosage forms , highly potent products and cytotoxic material. We also have experience in a range of modular laboratories for TSE research, ...

78

Regulation of lactose catabolism in Streptococcus mutans: purification and regulatory properties of phospho-beta-galactosidase.

Regulation of G1 Cell Cycle Progression

Phospho-beta-galactosidase (P-beta-gal), the enzyme which catalyzes the first step in the metabolism of intracellular lactose phosphate, occurred at high specific activity in the cytoplasm in 12 of...Full Text Available

1979-01-01

79

Predicting the carcinogenicity of chemicals in humans from rodent bioassay data.

Most genetic changes that promote tumorigenesis involve dysregulation of G1 cell cycle progression. A key regulatory site in G1 is a growth factor–dependent restriction point (R) where cells...Full Text Available

2010-11-01

80

Predicting Protein Post-translational Modifications Using Meta-analysis of Proteome Scale Data Sets*S?

Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans. We argue that it is always more useful to...Full Text Available

1991-08-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

81

Policy Progress for Physician Treatment of Opiate Addiction

Protein post-translational modifications are an important biological regulatory mechanism, and the rate of their discovery using high throughput techniques is rapidly increasingly. To make use of this...Full Text Available

2009-02-01

82

Phosphorylation-dependent power output of transgenic flies: an integrated study.

Medical treatment of heroin addiction with methadone and other pharmacotherapies has important benefits for individuals and society. However, regulatory policies have separated this treatment from the...Full Text Available

2002-05-01

83

Occupational health priorities for health standards: the current NIOSH approach.

We examine how the structure and function of indirect flight muscle (IFM) and the entire flight system of Drosophila melanogaster are affected by phosphorylation of the myosin regulatory light chain...Full Text Available

1997-12-01

84

Nuclear Regulatory Commission issuances. Volume 42, No. 6

Government agencies responsible for protecting the public from the adverse effects of toxic chemicals must set priorities for research, regulatory action, protocol testing, and monitoring due to the...Full Text Available

1979-05-01

85

Nuclear Regulatory Commission issuances, June 1984. Volume 19, No. 6

This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (AU), the Directors` Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM).

1995-12-01

86

Nuclear Regulatory Commission issuances

This report includes the issuances received during the specified period from the Commission, the Atomic Safety and Licensing Appeal Boards, the Atomic Safety and Licensing Boards, the Administrative Law Judge, the Directors' Decisions, and the Denials of Petitions for Rulemaking.

1984-06-01

87

Nuclear Regulatory Commission Issuances

This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), the Directors' Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM).

1982-02-01

88

Nuclear Regulatory Commission Issuances

This report includes the issuances received during the specified period from the Commission (CLl), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), The Directors' Decisions (DD), and the Denials of Petitions For Rulemaking (DPRM).

1982-06-01

89

NRC regualtory agenda. Semiannual report, July 1997--December 1997

This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM).

1996-12-01

90

Molecular basis of FIR-mediated c-myc transcriptional control

The Regulatory Agenda is a semiannual compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and of all petitions for rulemaking that the NRC has received that are pending disposition.

1998-02-01

91

Metabolic labeling and direct imaging of choline phospholipids in vivo

The Far UpStream Element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, the FBP transcriptional activator binds to the FUSE DNA element upstream...Full Text Available

2010-09-01

92

Matching ATP Supply and Demand in Mammalian Heart: In Vivo, In Vitro and In Silico Perspectives

Choline (Cho)-containing phospholipids are the most abundant phospholipids in cellular membranes and play fundamental structural as well as regulatory roles in cell metabolism and signaling. Although...Full Text Available

2009-09-08

93

Markets and commercialization scenarios for emerging fuel cells in evolving electricity markets

Although the heart rapidly adapts cardiac output to match the body’s circulatory demands, the regulatory mechanisms ensuring that sufficient ATP is available to perform the required...Full Text Available

2010-02-01

94

Mapping of the transcription start site (TSS) and identification of SNPs in the bovine neuropeptide Y (NPY) gene

Electricity markets in the United States are undergoing unprecedented structural changes as a result of the confluence of regulatory, competitive, and technological forces. This paper introduces these structural changes and forces and discuss the implications, markets and commercialization scenarios for emerging fuel cells in evolving US electricity markets.

1996-12-31

95

MANUAL: COMBINED SEWER OVERFLOW CONTROL

BackgroundNeuropeptide Y is a key neurotransmitter of the central nervous system which plays a vital role in the feed energy homeostasis in mammals. Mutations in the regulatory and...Full Text Available

96

Intrinsic expression of host genes and intronic miRNAs in prostate carcinoma cells

This manual provides information to assist in selection and designing control measures for reducing pollutant discharges from combined sewer overflows (CSOs). he manual will be useful for municipal public works staff, design engineers, and regulatory agency staff tasked with the ...

97

Inferring gene regulatory networks from asynchronous microarray data with AIRnet

BackgroundRecent data show aberrant and altered expression of regulatory noncoding micro (mi) RNAs in prostate cancer (PCa). A large number of miRNAs are encoded in organized intronic...Full Text Available

98

Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells

BackgroundModern approaches to treating genetic disorders, cancers and even epidemics rely on a detailed understanding of the underlying gene signaling network. Previous work has...Full Text Available

99

Increased degradation of MYPT1 contributes to the development of tolerance to nitric oxide in porcine pulmonary artery

BackgroundThe immunoregulatory enzyme indoleamine 2,3-dioxygenase, which catalyzes the conversion of tryptophan into kynurenine, is expressed in a significant subset of patients...Full Text Available

2010-12-01

100

Identification of cell cycle-related regulatory motifs using a kernel canonical correlation analysis

Myosin phosphatase target subunit 1 (MYPT1) is the regulatory subunit of myosin light chain phosphatase (MLCP). It plays a critical role in vasodilatation induced by cGMP-elevating agents such as nitric...Full Text Available

2010-07-01

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101

Identification of a distant cis-regulatory element controlling pharyngeal arch-specific expression of zebrafish gdf6a/radar

BackgroundGene regulation is a key mechanism in higher eukaryotic cellular processes. One of the major challenges in gene regulation studies is to identify regulators affecting the...Full Text Available

102

Generation of Novel Bacterial Regulatory Proteins That Detect Priority Pollutant Phenols

Skeletal formation is an essential and intricately regulated part of vertebrate development. Humans and mice deficient in Growth and Differentiation Factor 6 (Gdf6) have numerous...Full Text Available

2010-04-01

103

Gene-enzyme telationships in somatic cells and their organismal derivatives in higher plants. Progress report

The genetic systems of bacteria that have the ability to use organic pollutants as carbon and energy sources can be adapted to create bacterial biosensors for the detection of industrial pollution....Full Text Available

2000-01-01

104

Epitope tagging of endogenous proteins for genome wide Chromatin immunoprecipitation analysis

Progress is reported in the following subject areas: (1) chemistry of the arogenate molecule; (2) plant enzymology at the organismal level; (3) isolation of regulatory mutants in tobacco; and (4) stability of the haploid state in Nicotiana sylvestris.

1980-04-21

105

Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules

The development of chromatin immunoprecipitation methods coupled with DNA microarray (ChIP-chip) technology has enabled genome-wide identification of cis-DNA regulatory elements to which transcription...Full Text Available

2009-01-01

106

Emergence of Switch-Like Behavior in a Large Family of Simple Biochemical Networks

The programming of cellular networks to achieve new biological functions depends on the development of genetic tools that link the presence of a molecular signal to gene-regulatory activity. Recently,...Full Text Available

2011-07-01

107

Effects of PKA phosphorylation on the conformation of the Na,K-ATPase regulatory protein FXYD1

Bistability plays a central role in the gene regulatory networks (GRNs) controlling many essential biological functions, including cellular differentiation and cell cycle control. However, establishing...Full Text Available

2011-05-01

108

Economic Impact Analysis of Proposed Effluent Limitations Guidelines and Standards for the Pesticide Manufacturing Industry.

FXYD1 (phospholemman) is a member of an evolutionarily conserved family of membrane proteins that regulate the function of the Na,K-ATPase enzyme complex in specific tissues and specific physiological...Full Text Available

2009-11-01

109

EPA INDUSTRIAL BOILER FGD (FLUE GAS DESULFURIZATION) SURVEY: FIRST QUARTER 1978

The report details the economic impact of two alternative regulatory options; a Treated Discharge Option and a Zero Discharge Option on facilities that would have to comply with the regulations as part of the reproposal of effluent limitations and standar...

1992-01-01

110

Disruption of Putative Regulatory Loci in Listeria monocytogenes Demonstrates a Significant Role for Fur and PerR in Virulence

The report presents detailed technical information concerning application of flue gas desulfurization (FGD) systems to industrial boilers. The information was obtained by a survey of plant personnel, control system vendors, regulatory agencies, and consulting engineering firms. T...

111

Cost-Effectiveness Analysis of Proposed Effluent Limitations Guidelines and Standards for the Metal Products and Machinery Industry (Phase 1).

The ability to adapt to adverse environmental conditions encountered in food and during host infection is a sine qua non for a successful Listeria monocytogenes infection. This ability...Full Text Available

2004-02-01

112

Cost-Effectiveness Analysis of Proposed Effluent Limitations Guidelines and Standards for the Centralized Waste Treatment Industry.

This cost-effectiveness analysis supports the proposed effluent limitations guidelines and standards for the Metal Products and Machinery Industry (MP and M) Phase I Industry. The report assesses the cost-effectiveness of five regulatory options for indir...

1995-01-01

113

Comparative Structural Analysis of Lipid Binding START Domains

This analysis, submitted in support of proposed effluent limitations guidelines and standards for the centralized waste treatment (CWT) industry, investigates the cost-effectiveness of 24 regulatory options, representing all possible combinations of nine ...

1995-01-01

114

Common Genetic Variants Associate with Serum Phosphorus Concentration

BackgroundSteroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind....Full Text Available

115

Carotenoid Crystal Formation in Arabidopsis and Carrot Roots Caused by Increased Phytoene Synthase Protein Levels

Phosphorus is an essential mineral that maintains cellular energy and mineralizes the skeleton. Because complex actions of ion transporters and regulatory hormones regulate serum phosphorus concentrations,...Full Text Available

2010-07-01

116

Cardiac Myosin Is a Substrate for Zipper-interacting Protein Kinase (ZIPK)*

BackgroundAs the first pathway-specific enzyme in carotenoid biosynthesis, phytoene synthase (PSY) is a prime regulatory target. This includes a number of biotechnological approaches...Full Text Available

117

CANDU licensing in Korea : status review and future requirements

Zipper-interacting protein kinase (ZIPK) is a member of the death-associated protein kinase family associated with apoptosis in nonmuscle cells where it phosphorylates myosin regulatory light chain...Full Text Available

2010-02-19

118

Biosynthesis and Uptake of Siderophores Is Controlled by the PacC-Mediated Ambient-pH Regulatory System in Aspergillus nidulans

The licensing status and procedures, regulatory framework, and current safety issues of CANDU type reactors, Wolsong units 2, 3 and 4 are examined. Licensing difficulties and lessons learned during the safety review of Wolsong 2, 3 and 4 and future requirements are also summarized. The review was conducted, not only to confirm the design adequacy with respect to the domestic atomic laws and regulatory requirements of the vendor country, Canada, but also to reflect into the design the lessons learned from the regulatory experiences of operating Wolsong I to enhance the safety as high as practically possible. Safety issues observed during the licensing review, such as containment integrity, fuel channel integrity, etc., are summarized. Several efforts have been conducted to harmonize the Canadian regulations with the Korean ones by establishing domestic regulatory positions and guidelines. For example, ...

1998-05-03

119

Antibodies to synthetic peptides from the tubulin regulatory domain interact with tubulin and microtubules.

Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system...Full Text Available

2004-04-01

120

Activation of Cytotoxic and Regulatory Functions of NK Cells by Sindbis Viral Vectors

The carboxyl-terminal region of tubulin alpha and beta subunits plays a major role in regulating its assembly into microtubules and constitutes an essential domain for the selective interaction of microtubule-associated...Full Text Available

1988-09-01

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121

AN EVALUATION OF THE DISPOSAL OF FLUE GAS DESULFURIZATION WASTES IN MINES AND THE OCEAN: INITIAL ASSESSMENT

Oncolytic viruses (OVs) represent a relatively novel anti-cancer modality. Like other new cancer treatments, effective OV therapy will likely require combination with conventional treatments. In order...Full Text Available

122

ADP-Glucose Pyrophosphorylase, a Regulatory Enzyme for Bacterial Glycogen Synthesis

The report gives an initial assessment of the feasibility of disposing of flue gas desulfurization wastes in mines and in the ocean. The purpose of the assessment was to evaluate environmental, technical, regulatory, and economic aspects of the use of such disposal sites. Availab...

123

A polyacetylene compound from herbal medicine regulates genes associated with thrombosis in endothelial cells

The accumulation of α-1,4-polyglucans is an important strategy to cope with transient starvation conditions in the environment. In bacteria and plants, the synthesis of glycogen and starch occurs...Full Text Available

2003-06-01

124

A multistep bioinformatic approach detects putative regulatory elements in gene promoters

From Toki-shakuyaku-san, an herbal formulation for “cleansing stagnated blood,” a key gene regulatory compound was purified and identified through a screening based on DNA microarray...Full Text Available

2007-12-15

125

A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish

BackgroundSearching for approximate patterns in large promoter sequences frequently produces an exceedingly high numbers of results. Our aim was to exploit biological knowledge for...Full Text Available

126

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells

BackgroundGATA-2 is a transcription factor required for hematopoietic stem cell survival as well as for neuronal development in vertebrates. It has been shown that specific expression...Full Text Available

127

A classification-based framework for predicting and analyzing gene regulatory response

KLF1 regulates a diverse suite of genes to direct erythroid cell differentiation from bipotent progenitors. To determine the local cis-regulatory contexts and transcription factor networks...Full Text Available

2010-08-01

128

A Novel Nuclear-Localized CCCH-Type Zinc Finger Protein, OsDOS, Is Involved in Delaying Leaf Senescence in Rice1[W

BackgroundWe have recently introduced a predictive framework for studying gene transcriptional regulation in simpler organisms using a novel supervised learning algorithm called...Full Text Available

129

State of work for services provided by the Waste Sampling and Characterization Facility for effluent monitoring

Leaf senescence is a developmentally programmed degeneration process, which is fine tuned by a complex regulatory network for plant fitness. However, molecular regulation of leaf senescence is poorly...Full Text Available

2006-08-01

130

Radiation safety in industrial applications

This document defines the services the Waste Sampling and Characterization Facility (WSCF) shall provide Effluent Monitoring (EM) throughout the calendar year for analysis. The internal memo contained in Appendix A identifies the samples Em plans to submit for analysis in CY-1995. Analysis of effluent (liquid and air discharges) and environmental (air, liquid, animal, and vegetative) samples is required using standard laboratory procedures, in accordance with regulatory and control requirements. This report describes regulatory reporting requirements and WSCF services and data quality objectives.

131

Hanford tanks initiative plan

Oil and gas industry is the largest user of radioactive materials in Nigeria. They make use of radiation generators, sealed and unsealed radioactive sources.Some of these are potentially dangerous to human health and environment if not properly controlled. here is also the need to maintain control over occupational exposures to radiation, as well as to protect the public and the environment through proper management of wastes that may be radiologically hazardous. To minimize these, effective regulatory infrastructure is being put in place.For a smooth take-off of the nuclear power program, the National Nuclear Regulatory Authority and other stake holders in the nuclear industry need to start to put together licensing procedure for these.

2008-03-17

132

Development of regulatory techniques for operational performance evaluation of nuclear power plants

Abstract: The Hanford Tanks Initiative (HTI) is a five-year project resulting from the technical and financial partnership of the U.S. Department of Energy`s Office of Waste Management (EM-30) and Office of Science and Technology Development (EM-50). The HTI project accelerates activities to gain key technical, cost performance, and regulatory information on two high-level waste tanks. The HTI will provide a basis for design and regulatory decisions affecting the remainder of the Tank Waste Remediation System`s tank waste retrieval Program.

1997-07-01

133

Technical support for nuclear regulatory activity and the Italian experience

In this study, the state-of-the art for estimating LERF is considered for the regulatory risk-informed decisions. The consideration is mainly focused on (1) the relationship between Level 2 PSA and LERF evaluation methodology, (2) the standard requirements in terms of modeling preparation and the acceptance criteria based on the application capability II of ASME PRA standard, and (3) some pending issues for developing and proposing a simplified LERF model. This study is preliminarily presented and will be updated for establishing detailed evaluation scheme of extended MPAS (multi-purpose probabilistic analysis of safety) model and preparing the technical basis.

2006-01-15

134

Regulatory quality assurance requirements for the operation of nuclear R and D facilities in Korea

Different cases exist in various countries regarding the institutional status, the organization and the technical resources of the Nuclear Regulatory Authority (NRA): there are NRAs having extended internal technical capability and others relying mostly on external technical support. Considering the research and development activities and the very broad range of technical matters on which the regulatory and licensing activity are based, the NRA can not rely only on internal resources, and generally there is the need of technical and scientific support together with enhanced international cooperation. The international cooperation and networking among NRAs, and their Technical Support Organizations (TSO), represents a fundamental way to maintain competence, capability and knowledge. Within the EU member states this is becoming more and more an institutional duty. In providing technical support for regulatory activity, the ...

2007-08-01

135

Trans-activation of the JC virus late promoter by the tat protein of type 1 human immunodeficiency virus in glial cells

Full text: Korea Atomic Energy Research Institute (KAERI) has many R and D facilities in operation. including HANARO research reactor, radioactive waste treatment facility (RWTF), post-irradiation examination facility (PIEF) and irradiated material test facility (IMEF). Recently. nation-wide interest is focused on the safety and security of major industrial facilities. Safe operation of nuclear facilities is imperative because of the consequence of public disaster by radiological release/contamination, in case of an accident. Recently, Ministry of Science and Technology (MOST) of the Korean government announced amendments of Atomic Energy laws to enforce requirements of the physical protection and radiological emergency. All provisions on nuclear safety regulation and radiation protection are entrusted to the Atomic Energy Act(AEA). The Act is enacted as the main law concerning the safety regulation of nuclear installations, and is supplemented by the Enforcement Decree and Enforcement ...

2006-10-15

136

Regulatory review of reactor physics design aspects of TAPP-3 and 4

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the JC virus (JCV), a human papovavirus. PML is a relatively rare disease seen predominantly in immunocompromised individuals and is a frequent complication observed in AIDS patients. The significantly higher incidence of PML in AIDS patients than in other immunosuppressive disorders has suggested that the presence of human immunodeficiency virus type 1 (HIV-1) in the brain may directly or indirectly contribute to the pathogenesis of this disease. In the present study the authors have examined the expression of the JCV genome in both glial and non-glial cells in the presence of HIV-1 regulatory proteins. They find that the HIV-1-encoded trans-regulatory protein tat increases the basal activity of the JCV late promoter, JCV{sub L}, in glial cells. They conclude that the presence of the HIV-1-encoded tat protein may positively ...

1990-05-01

137

Regulation by small RNAs via coupled degradation: mean-field and variational approaches

Atomic Energy Regulatory Board carries out the regulatory review of the reactor physics design, commissioning and operational aspects through Project Design Safety Committee and Specialist Group of reactor physicists with wide experience in the design, commissioning and operational safety review of NPPs. TAPP-3 and 4 PHWRs, being the first indigenous design of 540 MWe Units, are quite different than the standard 220 MWe PHWRs. The safety review of reactor physics design was quite complex, as majority of the systems were new. The Reactor Physics Specialist Group carried out extensive safety review of 540 MWe PHWR reactor physics design and made significant contributions of design modifications and improvements in the operational procedures. Some salient contributions include: Monitoring the core during bulk addition of moderator without the availability of shutdown systems. Logics for providing safety cover in case of malfunction of SDS-1, Use ...

2006-11-13

138

CERN Document Server

Regulatory genes called small RNAs (sRNAs) are known to play critical roles in cellular responses to changing environments. For several sRNAs, regulation is effected by coupled stoichiometric degradation with messenger RNAs (mRNAs). The nonlinearity inherent in this regulatory scheme indicates that exact analytical solutions for the corresponding stochastic models are intractable. Here, we present a variational approach to analyze a well-studied stochastic model for regulation by sRNAs via coupled degradation. The proposed approach is efficient and provides accurate estimates of mean mRNA levels as well as higher order terms. Results from the variational ansatz are in excellent agreement with data from stochastic simulations for a wide range of parameters, including regions of parameter space where mean-field approaches break down. The proposed approach can be applied to quantitatively model stochastic gene expression in complex ...

2011-01-01

139

NRC regulatory agenda: Semiannual report, January--June 1997. Volume 16, Number 1

Law as an organizational variable: an examination of the impact of law on the performance of the US Nuclear Regulatory Commission

The Regulatory Agenda is a semiannual compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and of all petitions for rulemaking that the NRC has received that are pending disposition. The agenda consists of two sections that have been updated through June 30, 1997. Section 1, ``Rules,`` includes (A) rules on which final action has been taken since December 31, 1996, the closing date of the last NRC Regulatory Agenda; (B) rules published previously as proposed rules on which the Commission has not taken final action; (C) rules published as advance notices of proposed rulemaking for which neither a proposed nor final rule has been issued; and (D) unpublished rules on which the NRC expects to take action. Section 2, ``Petitions for Rulemaking,`` includes (A) petitions denied or incorporated into final rules since December 31, 1996; (B) petitions incorporated into proposed rules; ...

1997-08-01

140

The role of law in a federal regulatory agency is examined from an organizational perspective. While law is usually viewed in terms of its legal, political, and social value consequences, it is postulated that it also has significant organizational consequences. The impact of those consequences is examined in the case of a single agency, the US Nuclear Regulatory Commission. The legal process is shown to be a powerful organizational characteristic of the government administrative agency, beginning with statuatory definition of organization goals, structure, and procedures and ending with judicial review of actions. Agency lawyers are shown to represent a distinct professional subculture within this agency. Their values and orientations toward business, the role of regulation, and the role of nuclear utilities are different from the 95% of agency employees subculture based on a physical science/engineering background. It is concluded that agency ...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

141

FINAL CLOSE-OUT REPORT

Technical support organization of Armenian Nuclear Regulatory Authority: establishment, development and current status

The Interstate Oil and Gas Compact Commission (IOGCC) engaged in numerous projects outlined under the scope of work discussed in the United States Department of Energy (DOE) grant number DE-FG26-01BC15336 awarded to the IOGCC. Numerous projects were completed that were extremely valuable to state oil and gas agencies as a result of work performed utilizing resources provided by the grant. There are numerous areas in which state agencies still need assistance. This additional assistance will need to be addressed under another grant because funding resources have been exhausted under The scope of work objectives for the eight projects covered under this grant is as follows: (1) Improve uniformity within state oil and gas data management efforts. (2) Conduct environmental compliance workshops and related educational projects on natural gas and oil exploration and production. (3) Improve regulatory efficiency through partnering opportunities provided by the Appalachian ...

2004-08-03

142

Summary of Information Presented at an NRC-Sponsored Low-Power Shutdown Public Workshop, April 27, 1999, Rockville, Maryland

In 1993 the Government of Armenia made a decision to restart Armenian Nuclear Power Plant (ANPP) which was shutdown in 1989. Shortly after that decision Armenian Nuclear Regulatory Authority (ANRA) was established. Absence of local technical support and limited international support created difficulties for new established ANAR during its activities on regulating ANPP modernization process and issuing authorization for restart. Necessity to establish TSO occurred at this stage. By initiative of ANRA a small TSO was established in 2002 with limited staff called Nuclear and Radiation Safety Centre (NRSC). This paper briefly describes the establishment, development and the current activities and problems of NRSC. (author)

2007-08-01

143

Review and evaluation of the Nuclear Regulatory Commission Safety Research Program for fiscal year 1985. A report to the Congress of the United States of America

This report summarizes a public workshop that was held on April 27, 1999, in Rockville, Maryland. The workshop was conducted as part of the US Nuclear Regulatory Commission's (NRC) efforts to further develop its understanding of the risks associated with low power and shutdown operations at US nuclear power plants. A sufficient understanding of such risks is required to support decision-making for risk-informed regulation, in particular Regulatory Guide 1.174, and the development of a consensus standard. During the workshop the NRC staff discussed and requested feedback from the public (including representatives of the nuclear industry, state governments, consultants, private industry, and the media) on the risk associated with low-power and shutdown operations.

1999-07-01

144

Review and evaluation of the Nuclear Regulatory Commission Safety Research Program for Fiscal Years 1984 and 1985

This is the seventh report by the Advisory Committee on Reactor Safeguards (ACRS) in response to the Congressional requirement for an annual report on the Nuclear Regulatory Commission (NRC) Reactor Safety Research Program. As previously requested by the Congress, the timing of this report has been adjusted to enable the ACRS to address the proposed budget for FY 1985 that has been submitted to the Congress by the President. Part I is a compilation of our comments and recommendations regarding the NRC Safety Research Program budget for FY 1985. It is intended to serve as an Executive Summary. Part II is divided into eight chapters, each of which represents a Decision Unit of the NRC research program. In each chapter, specific comments are included on the research involved in the Decision Unit, an assessment of priorities, and recommendations regarding new directions and levels of funding.

1984-02-01

145

Permissibility under international law of the disposal of radioactive waste into the sub-seabed. Die voelkerrechtliche Zulaessigkeit des Verbringens radioaktiver Stoffe in den Meeresuntergrund

This is the sixth report by the Advisory Committee on Reactor Safeguards (ACRS) that has been prepared in response to the Congressional requirement for an annual report on the Nuclear Regulatory Commission (NRC) Reactor Safety Research Program. Part I is a compilation of our general comments and recommendations regarding the NRC Safety Research Program, and includes budget recommendations and an identification of matters of special importance that deserve increased emphasis. It is intended to serve as an Executive Summary. Part II is divided into ten chapters, each of which represents a Decision Unit of the NRC research program. In each chapter, specific comments are included on the research involved in the Decision Unit, an assessment of priorities, and recommendations regarding new directions and levels of funding.

1983-02-01

146

Nigeria's radioactive waste management policy and strategy document

The author investigates whether the international law regime so far has developed any legal principles dealing with the problem of the dumping of radioactive waste in the sub-seabed, and whether any of such provisions available adequately tackle the problem in the light of the gravity of danger emanating from radioactive waste. The study covers over 30 different texts of international treaties and protocols. Points of main interest are the London Dumping Convention and the Montego Bay Convention on the Law of the Sea. The author concludes that the disposal of radioactive waste into the seabed belongs to the permissible, although not specially allowed activities within the framework of the freedom of the high seas, and therefore urgently calls for establishing an international regulatory system pertaining to the planning and accomplishment of such activities. An outline legal concept of a regulatory system is explained. (orig./HSCH).

1986-01-01

147

Molecular biology of the renin-angiotensin system

Radioactive waste for legal and regulatory purposes may be defined as material that contains or is contaminated with radio-nuclides at concentrations or activities greater than clearance levels as established by the regulatory body, and for which no use is foreseen. Safe management of radioactive waste is essential to ensure protection of humans and environment. Radioactive waste management policy is a guideline for the safe management of radioactive waste. It expresses the commitment of the country towards the goal. Government should initiate investigation into best long-term option for management of spent nuclear fuels. Process of selecting option and eventual site should involve comprehensive public participation within set time frames (with deep geological disposal as preferred management option).

2009-07-14

148

Interim radiological safety standards and evaluation procedures for subseabed high-level waste disposal

This paper reviews the molecular biology of the renin-angiotensin system. The renin gene structure is analyzed in detail, including an examination of the putative regulatory regions. The combined action of these regulatory sequences would result in the complex, tissue-specific expression and regulation observed in vivo. The expression of the tissue renin-angiotensin systems, which may have important physiological functions, is also described. In addition, the pathway of renin biosynthesis and secretion is reviewed. This includes speculation on the fate of circulating prorenin and the physiological role of multiple renin forms and secretory pathways. The molecular approaches described in this paper have greatly advanced our knowledge of the biology of the renin-angiotensin system. Future studies using these and other approaches should provide further insight into this complex system.

1988-10-01

149

Insights from Development of Regulatory PSA Model for SMART

The Seabed Disposal Project (SDP) was evaluating the technical feasibility of high-level nuclear waste disposal in deep ocean sediments. Working standards were needed for risk assessments, evaluation of alternative designs, sensitivity studies, and conceptual design guidelines. This report completes a three part program to develop radiological standards for the feasibility phase of the SDP. The characteristics of subseabed disposal and how they affect the selection of standards are discussed. General radiological protection standards are reviewed, along with some new methods, and a systematic approach to developing standards is presented. The selected interim radiological standards for the SDP and the reasons for their selection are given. These standards have no legal or regulatory status and will be replaced or modified by regulatory agencies if subseabed disposal is implemented. 56 refs., 29 figs., 15 tabs.

1997-06-01

150

Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantation

SMART (System-Integrated Modular Advanced Reactor) is a first-of-the-kind integral reactor with 330 MW thermal power under active development by Korea Atomic Energy Research Institute (KAERI) for power generation and seawater desalination. SMART employs various design features that are not typically found in other nuclear power plants. Examples include a unique passive residual heat removal system (PRHRS), and enclosure of a pressurizer, eight helical steam generators, and eight canned reactor coolant pumps inside the reactor pressure vessel. This paper presents risk insights on the SMART reactor gained during the development of a regulatory PSA model by Korea Institute of Nuclear Safety (KINS)

2010-10-01

151

British Library Electronic Table of Contents (United Kingdom)

Introduction: Haploidentical transplantation, with extensive T cell depletion to prevent GvHD, is associated with a high incidence of infection-related deaths. The key challenge is to improve immune recovery with allogeneic donor T cells without triggering GvHD. As T regulatory cells (Tregs) controlled GvHD in pre-clinical studies, the present study evaluated the impact of an infusion of donor CD4/CD25 + Tregs, followed by an inoculum of donor mature T cells (Tcons) and positively immunoselected CD34 + cells in the setting of haploidentical stem cell transplantation. Patients and methods: Twenty-eight patients were enrolled in this study (22 AML; 5 ALL; 1 NHL). All received immunoselected Tregs (CliniMACS, Miltenyi Biotec) followed by positively immunoselected CD34 + cells together with Tc...

2011-01-01

152

Draft Regulatory Rule-making for On-line Maintenance of Nuclear Power Plants

Current waste-management practices and operations at Oak Ridge National Laboratory, 1982

Internationally, on-line maintenance (OLM) of nuclear power plants under the operation is prevailed to enhance nuclear safety and economics. In recent years, Korea Hydro and Nuclear Power Co. Ltd. (KHNP) is eager to apply OLM. Ministry of Education, Science and Technology (MEST) has established the related technology development program as an item of 'Overall Planning on Nuclear Safety(2010-2014)' through acceptance to the request of KHNP in 2009. OLM is defined as maintenance that is performed with the main generator connected to the grid. In other words, it means a preventive maintenance to be implemented during the allowable outage time (AOT) with ignoring inoperability of safety-related equipment listed in the technical specifications. The Korea Institute of Nuclear Safety (KINS) is developing the assessment technology of safety concerns for OLM under the auspices of MEST. Draft regulatory rule-making for OLM is devised as a part of the development of the ...

2010-10-01

153

Cost-effectiveness analysis for proposed effluent limitations guidelines and standards for the coastal subcategory of the oil and gas extraction point source category

The need for efficient management of industrial chemical wastes, especially those considered hazardous or radioactive, is receiving increased attention in the United States. During the past five years, several federal laws have addressed the establishment of stronger programs for the control of hazardous and residual wastes. At a facility such as Oak Ridge National Laboratory (ORNL), an efficient waste management program is an absolute necessity to ensure protection of human health and compliance with regulatory requirements addressing the treatment and disposal of hazardous, nonhazardous, and radioactive wastes. This report highlights the major regulatory requirements under which the Laboratory must operate and their impact on ORNL facilities. Individual waste streams, estimates of quantities of waste, and current waste management operations are discussed.

1982-09-01

154

Biological scarcity: looking beyond regulatory exteriors in Taiwan

The analysis is submitted in support of the effluent limitations guidelines and standards for the Coastal Oil and Gas Industry. The report analyzes the cost-effectiveness of 10 regulatory options organized by three wastestreams. The document compares the total annualized cost incurred for each of the regulatory options within each wastestream to the corresponding effectiveness of that option in reducing the discharge of pollutants. Section Two discusses the cost-effectiveness methodology used and identifies the pollutants included in the analysis, presenting their toxic weighting factors and removal efficiencies. Section Three presents the results of the analysis. In Section Four, the cost-effectiveness values are compared to cost-effectiveness values for other promulgated rules. Appendix A presents data on pollutants, pollutant removals, annualized costs, and other, more detailed information.

1995-01-01

155

British Library Electronic Table of Contents (United Kingdom)

Research and bioethical policies are increasingly seen to facilitate, rather than to impede, scientific progress. Bioethical structures, nonetheless, often fail to account for or to shape the specific social surrounds in which scientific research is conducted. In Taiwan, a perceived shortage in human biological donations threatens to hamper stem cell research progress. This paper considers the stalled national biobank project and the lack of a reliable embryo supply for stem cell research, and suggests that one must look beyond regulatory structures in seeking explanations for such shortages. Specific aspects of Taiwan's democratization and social changes combine with problematic relations between patients and physicians to shape the terrain upon which human biologicals are given or withhe...

2011-01-01

156

An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes

Adalimumab treatment in Crohn's disease does not induce early changes in regulatory T cells

The authors have identified a protein present only in erythroid cells that binds to two adjacent sites within an enhancer region of the chicken {beta}-globin locus. Mutation of the sites, so that binding by the factor can no longer be detected in vitro, leads to a loss of enhancing ability, assayed by transient expression in primary erythrocytes. Binding sites for the erythroid-specific factor (Eryf1) are found within regulatory regions for all chicken globin genes. A strong Eryf1 binding site is also present within the enhancer of at least one human globin gene, and proteins from human erythroid cells (but not HeLa cells) bind to both the chicken and the human sites.

1988-08-01

157

British Library Electronic Table of Contents (United Kingdom)

Abstract Objective. Anti-TNF-a antibodies has been suggested to modulate regulatory T cell (Treg) percentages in rheumatoid arthritis, but results from studies of Crohn's disease (CD) are conflicting. We investigated dynamic changes of circulating Tregs in CD during treatment with the anti-TNF-a-antibody adalimumab (Humira, Abbott Laboratories A/S, Emdrupvej 28C, DK-2100 Copenhagen). Material and methods. Blood samples from 26 CD patients were analysed using flow cytometry before and 1 and 26 weeks after initiation of adalimumab treatment to determine the percentage of Tregs among CD4++ T cells. Results. In spite of a significant decline in disease activity scores and biochemical markers of inflammation, during the first week of treatment, we did not observe early modulating effects of ada...

2011-01-01

158

Accounting-related transmission issues

Wetlands: The changing regulatory landscape

Various initiatives have been undertaken by the Federal Energy Regulatory Commission (FERC) to deregulate wholesale electric energy markets. These initiatives have focused on restructuring the transmission systems in the US and recently have culminated in a proposal requiring formation of and participation in regional transmission organizations. The overall form of regulation selected to determine rates for transmission entities as well as underlying regulatory decisions reached on key issues will have profound implications for transmission entities. For example, traditional cost-based regulation would require one set of accounting and reporting rules, while incentive-based regulation may not be subject to those same rules. An overview of some of the major accounting and financial reporting issues that will need to be considered is presented.

1999-12-01

159

Type I (RI) and type II (RII) receptors for transforming growth factor-beta isoforms are expressed subsequent to transforming growth factor-beta ligands during excisional wound repair.

Protection of wetlands became a national issue in 1988 when President George Bush pledged no net loss of wetlands in the US under his [open quotes]environmental presidency.[close quotes] As wetlands became a national issue, the job of protecting them became an obligation for many groups, including hydro-power developers. Now, when a site selected for development includes an area that may be classified as a wetland, the developer quickly discovers the importance of recognizing and protecting these natural habitats. Federal legislation severely limits development of wetland, and most states increase the restrictions with their own wetlands regulations. The difficulty of defining wetlands complicates federal and state enforcement. Land that appears to be dry may in fact be classified as a wetland. So, even if a site appears dry, potential hydro developers must confirm whether or not any jurisdictional wetlands are present. Regulated lands include much more than marshes and swamps. Further ...

1993-05-01

160

Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter.

Transforming growth factor (TGF)-beta isoforms (TGF-beta 1, -beta 2, and -beta 3) regulate cell growth and differentiation and have critical regulatory roles in the process of tissue repair and remodeling....Full Text Available

1997-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

The direct interaction between ASH2, a Drosophila trithorax group protein, and SKTL, a nuclear phosphatidylinositol 4-phosphate 5-kinase, implies a role for phosphatidylinositol 4,5-bisphosphate in maintaining transcriptionally active chromatin.

The cell cycle-regulatory transcription factor E2F-1 is regulated by interactions with proteins such as the retinoblastoma gene product and by cell cycle-dependent alterations in E2F-1 mRNA abundance....Full Text Available

1994-10-01

162

The Atomic Energy Control Board criteria for identification and evaluation of fire hazards in nuclear power stations

The products of trithorax group (trxG) genes maintain active transcription of many important developmental regulatory genes, including homeotic genes. Several trxG proteins have been shown to act in...Full Text Available

2004-07-01

163

Synfuels: how much can they help. [Chevron activities

This report presents criteria for the identification and evaluation of fire hazards in nuclear power stations. The report presents criteria that are consistent with the existing regulatory approach in Canada, and outlines engineering tools and analytical techniques currently available to deterministically analyse fire. The criteria presented cover the topics which should be included in a fire hazard analysis and provide details of each topic so that the accuracy of an analysis may be evaluated.

2000-12-10

164

Study on institutionalization of risk-informed performance-based regulation

A series of questions and answers addresses issues related to developing synthetic fuels, including the potential supplies, regulatory road blocks, and development incentives to promote the role of the private sector. Chevron's efforts in the area of synfuels are aimed at shale oil tar sands and coal conversion. The status of these research and development projects and the projected recoverable reserves from each are summarized. (DCK)

165

Study on institutionalization of risk-informed performance-based regulation

In this study, for the institutionalization of risk informed and performance based regulation in Korea, the latest technical movements of overseas countries are examined and reviewed. And the issues that was found when license change petition using risk information was submitted in Korean regulatory body are reviewed. Based on these review, the applicable areas to domestic situation will be found and proposed. This study can contribute to setting up the proper direction for the institutionalization of risk informed and performance based regulation

2007-04-22

166

Resolution of key safety-related issues in FFTF regulatory review

In this study, for the institutionalization of risk informed and performance based regulation in Korea, the latest technical movements of overseas countries are examined and reviewed. And the issues that was found when license change petition using risk information was submitted in Korean regulatory body are reviewed. Based on these review, the applicable areas to domestic situation will be found and proposed. This study can contribute to setting up the proper direction for the institutionalization of risk informed and performance based regulation.

2003-02-15

167

Report of the Committee on Electric Utility Regulation

The FFTF is an ERDA facility which does not require licensing, but a technical review by NRC is required by ERDA policy. Safety issues which were not fully resolved in the course of the review for construction authorization have been the subject of continuing review since mid-1973. These issues included HCDA energetics, design fallback provisions for additional safety margins, piping integrity, and natural circulation core cooling.

168

Regulatory circuit for responses of nitrogen catabolic gene expression to the GLN3 and DAL80 proteins and nitrogen catabolite repression in Saccharomyces cerevisiae.

In 1991 the Federal Energy Regulatory Commission (FERC) continued it efforts to restructure the electric utility industry, emphasizing market-based pricing of wholesale power transactions and transmission access and pricing. Other issues covered in this report include pricing and policy initiatives, filing procedures, the generic rate of return on common equity, the price squeeze, contract interpretation, and legislative developments.

1992-01-01

169

Regulatory and technical reports (Abstract Index Journal): Compilation for third quarter 1986, July-September

We demonstrate that expression of the UGA1, CAN1, GAP1, PUT1, PUT2, PUT4, and DAL4 genes is sensitive to nitrogen catabolite repression. The expression of all these genes, with the exception of UGA1...Full Text Available

1993-01-01

170

Regulatory and technical reports (Abstract Index Journal). Annual compilation for 1985. Volume 10, No. 4

This journal includes all formal reports in the NUREG series prepared by the NRC staff and contractors, as well as proceedings of conferences and workshops. The entries in the compilation are indexed for access by title and abstract, contractor report number, personal author, subject, NRC organization, contractor, and licensed facility.

1986-11-01

171

Regulation about the technical environment of buildings: boiler-rooms / ventilation systems; RETA: chaufferies / ventilation

This journal includes all formal reports in the NUREG series prepared by the NRC staff and contractors, as well as proceedings of conferences and workshops. The entries in the compilation are indexed for access by title and abstract, contractor report number, personal author, subject, NRC organization, contractor, and licensed facility.

1986-02-01

172

Radioactive and mixed waste management plan for the Lawrence Berkeley Laboratory Hazardous Waste Handling Facility

This CD-Rom edited by the French scientific and technical committee of the space heating, ventilation and air-conditioning industry (CoSTIC) presents a series of technical files about ventilation and space heating systems with several references to the current regulatory texts. Modifications of the original legislative texts have been integrated to the original texts for a more comfortable reading. Search is performed using diagrams and key-words. (J.S.)

2000-06-01

173

Project quality assurance plant: Sodium storage facility, project F-031

This Radioactive and Mixed Waste Management Plan for the Hazardous Waste Handling Facility at Lawrence Berkeley Laboratory is written to meet the requirements for an annual report of radioactive and mixed waste management activities outlined in DOE Order 5820.2A. Radioactive and mixed waste management activities during FY 1994 listed here include principal regulatory and environmental issues and the degree to which planned activities were accomplished.

1995-01-01

174

Environmental Research Database

The Sodium Storage Facility Project Quality Assurance Plan delineates the quality assurance requirements for construction of a new facility, modifications to the sodium storage tanks, and tie-ins to the FFTF Plant. This plan provides direction for the types of verifications necessary to satisfy the functional requirements within the project scope and applicable regulatory requirements determined in the Project Functional Design Criteria (FDC), WHC-SD-FF-FDC-009.

175

Plant Sulphur Nutrition

DescriptionThe recent sequencing of the complete genomes of several streptomycete species revealed the presence of a large number of cryptic' secondary metabolic gene clusters, and led to the realisation that these organisms have the ability to produce many more natural products than had previously been recognised. One of the aims of our work is to identify the physiological signals and regulatory mechanisms responsible for the activation of these 'cryptic' pathways, thus unleashing the full biosynthetic p [continued...

2010-01-31

176

Nuclear Regulatory Commission issuances. Vol. 19, No. 4

Nuclear Regulatory Commission issuances. Vol. 16, No. 4

This report includes the issuances received during April 1984 from the Commission (CLI), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), the Directors' Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM).

1984-04-01

177

Nuclear Regulatory Commission issuances. Vol. 16, No. 1

This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), the Directors' Decisions (DD), and the Denials of Petitions For Rulemaking (DPRM).

1982-10-01

178

Nuclear Regulatory Commission issuances, Volume 18, No. 5

This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), the Director's Decisions (DD), and the Denials of Petitions For Rulemaking (DPRM).

1982-07-01

179

Nuclear Regulatory Commission issuances, January 1984. Vol. 19, No. 1

This report includes the issuances received during November, 1983, from the Commission (CLI), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), the Directors' Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM).

1983-11-01

180

NRC safety research in support of regulation. Selected highlights

This report includes the issuances received during January 1984 from the Commission (CLI), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), the Directors' Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM).

1984-01-01

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181

Mutations Affecting Motifs of Unknown Function in the Central Domain of Nitrogen Regulatory Protein C

The report presents selected highlights of how research has contributed to the regulatory effort. It explains the research role of the NRC and nuclear safety research contributions in the areas of: pressure vessel integrity, piping, small- and large-break loss-of-coolant accidents, hydrogen and containment, source term analysis, seismic hazards and high-level waste management. The report also provides a summary of current and future research directions in support of regulation.

1986-05-01

182

Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis.

The positive control function of the bacterial enhancer-binding protein NtrC resides in its central domain, which is highly conserved among activators of ς⁵⁴ holoenzyme. Previous...Full Text Available

1999-09-01

183

Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control.

The yeast phosphatidylinositol transfer protein (Sec14p) is required for biogenesis of Golgi-derived transport vesicles and cell viability, and this essential Sec14p requirement is abrogated by inactivation...Full Text Available

1996-12-02

184

Evolution of Hox Post-Transcriptional Regulation by Alternative Polyadenylation and MicroRNA Modulation Within 12 Drosophila Genomes.

We have isolated a human thrombomodulin cDNA, and a human genomic clone containing the putative promoter domain, as well as the translated and untranslated regions of the endothelial cell receptor....Full Text Available

1987-09-01

185

Enhanced ?₂-adrenergic receptor (?₂AR) signaling by adeno-associated viral (AAV)-mediated gene transfer

Hox genes encode a family of transcriptional regulators that operate differential developmental programs along the anteroposterior axis of bilateral animals. Regulatory changes affecting Hox gene expression are believed to have been crucial for the evolution of animal body plans. In Drosophila melanogaster, Hox expression is post-transcriptionally regulated by microRNAs (miRNAs) acting on target sites located in the 3' untranslated regions (3'UTRs) of Hox mRNAs. Notably, recent work has shown that during D. melanogaster development Hox genes produce mRNAs with variable 3'UTRs (short and long forms) in different sets of tissues as a result of alternative polyadenylation; importantly, Hox short and long 3'UTRs contain very different target sites for miRNAs. Here, we use a computational approach to explore the evolution of Hox 3'UTRs treated with especial regard to miRNA regulation. Our work is focused on the 12 Drosophila species for which genomic sequences are ...

2011-03-24

186

Economic analysis of proposed effluent limitations guidelines and standards for synthetic-based drilling fluids and other non-aqueous drilling fluids in the oil and gas extraction point source category

Backgroundβ₂-Adrenergic receptors (β₂AR) play important regulatory roles in a variety of cells and organ systems and are important therapeutic...Full Text Available

187

Developing geothermal heat pump demonstration projects

The Economic Analysis (EA) report is written to address the impacts of this proposed Effluent Limitation Guidelines and Standards for Synthetic-Based and Other Non-Aqueous Drilling Fluids. Currently, effluent guidelines pertaining to the discharge of drilling fluids address two specific types of fluids: Oil-based drilling fluids (OBFs) that use diesel and mineral oil, which are prohibited from being discharged; and Water-based drilling Fluids (WBFs), which can be discharged subject to meeting certain discharge requirements, including a sheen test and an aqueous toxicity test, in certain limited offshore regions. Section Two presents sources of data, Section Three presents the industry profile, Section Four discusses the regulatory costs of options under consideration for the proposed rulemaking, and Section Five discusses the impacts of the proposed rule on firms, well drilling, and production, and also briefly discusses secondary impacts such as those on ...

1999-02-01

188

Decommissioning and abandonment of onshore pipelines

The Sacramento Municipal Utility District is developing a number of demonstration projects using geothermal heat pumps. This paper discusses some of the barriers and issues that have emerged over the past two years. The most important barriers are: regulatory impediments; high first cost; and a lack of local design and installation infrastructure.

1995-12-31

189

DOE supports market-based pricing in case before FERC

The UK Pipelines Safety Regulations require the pipeline operator to ensure that a pipeline, once decommissioned, does not become a source of danger. Elsewhere, Regulatory Authorities require consideration of the possible issues which pipeline decommissioning may raise. This paper considers current practice with respect to pipeline decommissioning and abandonment, and sets out the range of factors which the operator must take into account. (author)

1999-07-01

190

Current status of the national and European regulatory regimes governing TPA and use of transmission systems for power produced from renewables and by dual-purpose power plants; Zum aktuellen Stand des nationalen und europaeischen Rechtsrahmens fuer die Durchleitung von Strom aus erneuerbaren Energien und Kraft-Waerme-Kopplung

The Department of Energy has used its seldom-used statutory authority and filed comments with the Federal Energy Regulatory Commission urging support for Public Service Company of Indiana's request that the FERC allow it to sell up to 450 megawatts of firm power to eligible wholesale purchasers at negotiated or market-based rates in exchange for open transmission access for other generators.

1990-04-12

191

Characterizing costs and benefits of uncertain future regulatory requirements on the U.S. natural gas industry

No abstract prepared

1999-11-01

192

BosR (BB0647) Controls the RpoN-RpoS Regulatory Pathway and Virulence Expression in Borrelia burgdorferi by a Novel DNA-Binding Mechanism

Environmental regulatory requirements at both the state and federal level are constantly changing, making it difficult for industry and R ampersand D program managers to project future compliance requirements and costs. Even if a company is trying to keep abreast of various proposed regulatory initiatives, the number of possible combinations of initiatives that could occur in the future seems virtually limitless. Uncertainty associated with potential future environmental compliance requirements makes the identification and evaluation of future investment and R ampersand D opportunities exceedingly difficult, and makes the process of systematic strategic planning increasingly complex. This paper describes a methodology for accounting for uncertain future environmental compliance costs in a systematic, comprehensive manner. Through analysis of proposed initiatives for making future environmental requirements more stringent, forecasting the ...

1995-03-27

193

Assessment of internal contamination due to gamma emitters at nuclear power stations of Tarapur

In Borrelia burgdorferi (Bb), the Lyme disease spirochete, the alternative σ factor σ⁵⁴ (RpoN) directly activates transcription of another alternative σ...Full Text Available

2011-02-01

194

Amplified B Lymphocyte CD40 Signaling Drives Regulatory B10 Cell Expansion in Mice

Personal monitoring and dose assessment of all radiation workers is an essential regulatory requirement as per radiation safety procedures of AERB and operating stations. The occupational workers of TAPS 1 and 2 and TAPS 3 and 4 are monitored for internal contamination due to high energy gamma emitters by whole body counting

2010-02-03

195

Ambient water-quality criteria for ammonia (salt water)-1989

BackgroundAberrant CD40 ligand (CD154) expression occurs on both T cells and B cells in human lupus patients, which is suggested to enhance B cell CD40 signaling and play a role...Full Text Available

196

Accelerator production of tritium pollution prevention design assessment

Ammonia is a common and highly toxic pollutant which, in sufficient quantities, will adversely affect aquatic organisms. This ammonia criteria document for salt water will allow establishment of regulatory standards for ammonia discharge into estuaries, near coastal zones and oceans. Possible adverse impacts in highly sensitive and abundant ecosystems such as estuaries make regulation particularly important.

1989-04-01

197

A region in the cytosolic domain of the epidermal growth factor receptor antithetically regulates the stimulatory and inhibitory guanine nucleotide-binding regulatory proteins of adenylyl cyclase.

This Pollution Prevention Design Assessment (PPDA) provides data for cost-benefit analysis of the potential environmental impact of the APT, is an integral part of pollution prevention/waste minimization, and is required by DOE for any activity generating radioactive, hazardous, and mixed wastes. It will also better position the APT to meet future requirements, since it is anticipated that regulatory and other requirements will continue to become more restrictive and demanding.

1997-09-18

198

Recent environment, energy and resources cases and issues in Alberta

Epidermal growth factor (EGF) stimulates adenylyl cyclase in the heart via activation of the stimulatory GTP-binding protein Gs. Therefore, employing peptides corresponding to regions in the cytosolic...Full Text Available

1995-03-14

199

Workshop on rock mechanics issues in repository design and performance assessment

Significant environmental issues and regulatory proceedings in Alberta were discussed. The Mackenzie Valley Pipeline Project was reviewed in relation to the Deh Cho First Nation's advanced actions in the federal court to enjoin the review panel from proceeding with the review process. The Deh Cho First Nation is seeking a declaration that the plan violates their rights under the Canadian Charter of Rights and Freedoms and the Constitution Act. Various regulatory and government agencies have now developed a plan to coordinate their different regulatory processes and approvals in the Cooperation Plan for the Environmental Impact Assessment and Regulatory Review of the Northern Gas Pipeline project. The Deh Cho allege that they were not afforded the opportunity to participate in the development and implementation of the plan. A review panel plans to proceed once the environmental and social ...

2005-07-01

200

Summary of the Waste Management Programs at uranium recovery facilities as they relate to the 40 CFR Part 192 standards

The Center for Nuclear Waste Regulatory Analyses organized and hosted a workshop on ``Rock Mechanics Issues in Repository Design and Performance Assessment`` on behalf its sponsor the U.S. Nuclear Regulatory Commission (NRC). This workshop was held on September 19- 20, 1994 at the Holiday Inn Crowne Plaza, Rockville, Maryland. The objectives of the workshop were to stimulate exchange of technical information among parties actively investigating rock mechanics issues relevant to the proposed high-level waste repository at Yucca Mountain and identify/confirm rock mechanics issues important to repository design and performance assessment The workshop contained three technical sessions and two panel discussions. The participants included technical and research staffs representing the NRC and the Department of Energy and their contractors, as well as researchers from the academic, commercial, and international technical communities. These ...

1996-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

201

Review and evaluation of the Nuclear Regulatory Commission Safety Research Program for fiscal years 1986 and 1987

This study evaluates the degree to which surface impoundments at licensed facilities comply with significant changes in NRC requirements initiated by enactment of EPA's final environmental standards for uranium recovery facilities (40 CFR Part 192). Impoundment liner requirements, ground-water protection standards, ground-water monitoring and corrective action programs, and site closure standards are the most significant regulatory modifications. The compliance status of 30 conventional mills and 31 in-situ mines is determined from a review of Nuclear Regulatory Commission and agreement state docket files through November, 1983. Results of this review show that a majority of conventional uranium mill tailings management systems are deficient with respect to liner requirements for new impoundments or proposed expansions to existing impoundments, as well as with respect to some aspects of ground-water monitoring and compliance programs. ...

202

Response of a Spent Fuel Transportation Cask to a Tunnel Fire Event

This is the eighth report by the Advisory Committee on Reactor Safeguards (ACRS) that has been prepared in response to the Congressional requirement for an annual report on the Nuclear Regulatory Commission (NRC) Reactor Safety Research Program. As previously requested by the Congress, the timing of this report has been adjusted to enable the ACRS to address the proposed budget for FY 1986 and 1987 that has been submitted to the Congress by the President. Detailed comments and recommendations are provided for the research programs and budget proposed for FY 1986. Because both the budget for FY 1987 and the research programs for that period are highly uncertain at this time, comments on these are not provided. Part I is a compilation of general comments and recommendations regarding the NRC Safety Research Program budget for FY 1986. It is intended to serve as the Executive Summary. Part II is divided into five chapters, each of which represents a Decision Unit of ...

1985-02-01

203

Report two. Safety offshore eastern Canada. Summary of studies and seminars

The staff of the Spent Fuel Project Office at the U.S. Nuclear Regulatory Commission undertook the investigation and thermal analysis of the Baltimore tunnel fire event. This event occurred in the Howard Street tunnel, in Baltimore, Maryland, on July 18, 2001. The staff was tasked with assessing the consequences of this event on the transportation of spent nuclear fuel. This paper describes the staff's coordination with the following government and laboratory organizations: the National Transportation Safety Board (NTSB), to determine the details of the train derailment and fire; the National Institute of Standards and Technology (NIST), to quantify the thermal conditions within the tunnel; the Center for Nuclear Waste Regulatory Analysis (CNWRA), to validate the NIST evaluations, and the Pacific Northwest National Laboratory (PNNL), to assist in the thermal analysis. The results of the staff's review and analysis efforts are ...

2003-02-25

204

Report of the US Nuclear Regulatory Commission Piping Review Committee. Volume 3. Evaluation of potential for pipe breaks

In 1982 the semi-submersible drilling unit Ocean Ranger capsized and sank off the Grand Banks, resulting in the loss of the entire 84-man crew. A Royal Commission was set up to conduct an enquiry into the incident, and to carry out a process of research and opinion-gathering towards providing recommendations to both federal and Newfoundland governments. The primary purpose of the Commission was to determine why the Ocean Ranger sank, why none of the crew were saved, and how to avoid similar disasters. A number of studies and seminars were held to focus expert knowledge and opinion in several key fields and to update studies and fill gaps in the data base. Summaries of selected study reports and the seminar proceedings are presented in the following areas: the environment, including ice, marine climatology, weather forecasting services, wave climatology, oceanographic information, and seabed information; design, including mobile offshore drilling rig design evolution, continuity from ...

1984-05-01

205

Regulatory requirements for design of safety related computer based control Systems in Indian PHWRs: case study of DPHS-PCS for TAPP-3 and 4

The Executive Director for Operations (EDO) in establishing the Piping Review Committee concurred in its overall scope that included an evaluation of the potential for pipe breaks. The Pipe Break Task Group has responded to this directive. This report summarizes a review of regulatory documents and contains the Task Group's recommendations for application of the leak-before-break (LBB) approach to the NRC licensing process. The LBB approach means the application of fracture mechanics technology to demonstrate that high energy fluid piping is very unlikely to experience double-ended ruptures or their equivalent as longitudinal or diagonal splits. The Task Group's reommendations and discussion are founded on current and ongoing NRC staff actions as presented in Section 3.0 of this report. Additional more detailed comments and discussion are presented in Section 5.0 and in Appendices A and B. The obvious issues are the reexamination of the large pipe ...

1984-11-01

206

Present status of thermal hydraulic research in severe accident of light water reactors in Japan

Computer based control systems for safety related applications in nuclear power plants have to meet not only the functional, performance and interface requirements, they in addition, have to meet regulatory requirements like enhanced reliability, safety and security and should provide fault tolerance, diagnostics and self-supervision. The control system architecture, hardware design and software design should meet requirements as specified in design code and guides of AERB. The Dual Processor Hot Standby Process Control System (DPHS-PCS) for TAPP-3 and 4 is a safety related (Class- IB) system. DPHS-PCS regulates PHT pressure, Pressuriser pressure, Pressuriser level, Bleed condenser pressure, Bleed condenser level and Steam generator pressure. The performance, reliability and safety requirements of this control system are met by employing a fault tolerant computer configuration developed for this purpose using hardware designed with facility for on-line diagnostics ...

2005-03-01

207

Organization of bulk power markets: A concept paper

Understanding of the thermal hydraulic phenomena is now the key issue in solving the severe accident problems of light water reactors. The Atomic Energy Society of Japan has organized a special committee on the evaluation of the thermal hydraulic phenomena in severe accident. The committee has continued the investigation of present status of thermal hydraulics in severe accident. Industries have completed the detailed implementation of the accident management measures, and industries have established also a self-regulatory document mainly on phase II accident management for the containment design of the future reactors. Present paper reviews the current status of evaluation activity referring to severe accident research in Japan. The phenomena included in this paper are (1) molten core behavior in lower plenum of pressure vessel, (2) fuel-coolant interaction, (3) molten core-concrete interaction, (4) direct containment heating, (5) hydrogen combustion, and (6) ...

2000-10-01

208

Negotiated settlements with a cost of service backstop: The consequences for depreciation

The electricity industry in the US today is at a crossroads. The restructuring debate going on in most regions has made it clear that the traditional model of vertically integrated firms serving defined franchise areas and regulated by state commissions may not be the pattern for the future. The demands of large customers seeking direct access to power markets, the entry of new participants, and proposed reforms of the regulatory process all signify a momentum for fundamental change in the organization of the industry. This paper addresses electricity restructuring from the perspective of bulk power markets. The authors focus attention on the organization of electricity trade and the various ways it has been and might be conducted. Their approach concentrates on conceptual models and empirical case studies, not on specific proposals made by particular utilities or commissions. They review literature in economics and power system engineering that is relevant to the ...

1995-12-01

209

Legal and regulation stability of the pipeline gas distribution market as strong tools for the sustainable development; A estabilidade juridica e regulatoria no mercado de distribuicao de gas canalizado como poderosas ferramentas de alcance de desenvolvimento sustentavel

The movement from traditional regulatory hearings to negotiated settlements represents both a departure from cost of service regulation and a relaxation of regulatory oversight. Under negotiation parties are able to renegotiate inclusions in their cost of service while simultaneously creating a profit margin for the regulated firm where none existed under the cost of service outcome of a traditional hearing. This paper constructs a model to illustrate the existence of positive gains to pipeline and shipper from the re-allocation of expenses through time in the regulated pipeline services market in Canada. Behaviour consistent with the model is observable in anecdotal and econometric evidence gathered from the library of the National Energy Board of Canada, responsible for pipeline toll regulation in Canada. Empirical investigation by into settlement procedures in the Florida electricity market reveals similar findings; however, this analysis ...

2011-03-01

210

Influence of organizational factors on performance reliability

This study examines, in general, the transformation of the role of the Brazilian state to intervener in supervisory of the services, through the delegation of responsibility for the exploitation of public services to private enterprise, and the creation of regulatory agencies. The study pointing to the necessity of a legal and regulatory stable scenario in the regulation of these services, as enables of private investment mechanisms and, as a consequence of sustainable economic development. The success of the neo liberal state model is examined, specifically in relation to the market of pipeline gas distribution, showing the environmental, economic and social benefits that brought in this sector, the private investment and stability so far reasonably observed in this segment. The work also indicating, in general, the risks and issues most relevant, from the investor and markets point of view, to attract and maintain investment and to reduce the ...

2004-07-01

211

Improving PSA quality of KSNP PSA model

This is the first volume of a two-volume report. Volume 2 will be published at a later date. This report presents the results of a research project conducted by Brookhaven National Laboratory for the United States Nuclear Regulatory Commission, Office of Nuclear Regulatory Research. The purpose of the project was to develop a general methodology to be use in the assessment of the organizational factors which affect performance reliability (safety) in a nuclear power plant. The research described in this report includes the development of the Nuclear Organization and Management Analysis Concept (GNOMIC). This concept characterizes the organizational factors that impact safety performance in a nuclear power plant and identifies some methods for systematically measuring and analyzing the influence of these factors on safety performance. This report is divided into two parts; Part 1 presents an overview of the development of the methodology, while ...

212

Gas supplies of interstate natural gas pipeline companies, 1987

In the RIR (Risk-informed Regulation), PSA (Probabilistic Safety Assessment) plays a major role because it provides overall risk insights for the regulatory body and utility. Therefore, the scope, the level of details and the technical adequacy of PSA, i.e. the quality of PSA is to be ensured for the successful RIR. To improve the quality of Korean PSA, we evaluate the quality of the KSNP (Korean Standard Nuclear Power Plant) internal full-power PSA model based on the 'ASME PRA Standard' and the 'NEI PRA Peer Review Process Guidance.' As a working group, PSA experts of the regulatory body and industry also participated in the evaluation process. It is finally judged that the overall quality of the KSNP PSA is between the ASME Standard Capability Category I and II. We also derive some items to be improved for upgrading the quality of the PSA up to the ASME Standard Capability Category II. In this paper, we ...

2004-07-01

213

GROWTH REGULATION IN ROUS SARCOMA VIRUS INFECTED CHICKEN EMBRYO FIBROBLASTS: THE ROLE OF THE src GENE

Gas Supplies of Interstate Natural Gas Pipeline Companies 1987 was prepared by the Reserves and Natural Gas Division, Office of Oil and Gas, Energy Information Administration (EIA). The publication provides information on the total reserves, production, and deliverability capabilities of the 87 interstate pipeline companies required to file the Federal Energy Regulatory Commission (FERC) Form 15, ''Interstate Pipeline's Annual Report of Gas Supply.'' This publication is the 25th in a series of annual reports on the total gas supplies of interstate pipeline companies since the inception of individual company reports to the Federal Power Commission (FPC) in 1964 for report year 1963. This publication provides information on the interstate pipeline companies' supply of natural gas during calendar year 1987, for use by the FERC for regulatory purposes. It also provides information to other ...

1988-12-08

214

Fiscal 1998 industrial science and technology R and D project. Research report on R and D of genome informatics technology (Development of stable oil supply measures using complex biosystem); 1998 nendo genome informatics gijutsu kenkyu kaihtsu seika hokokusho. Fukugo seibutsukei riyo sekiyu antei kyokyu taisaku kaihatsu

We report here a study of the mechanisms leading to loss of growth control in chicken embryo fibroblasts transformed by Rous sarcoma virus (RSV). We have been particularly concerned with the role of the src gene in this process, and have used RSV mutants temperature sensitive (ts) for transformation to investigate the nature of the growth regulatory lesion. The two principal findings were (1) the stationary phase of the cell cycle (G{sub 1}) in chick embryo fibroblasts seems to have two distinct regulatory compartments (using the terminology of Brooks et al. we refer to these as 'Q' and 'A' states). When rendered stationary at 41.5 C by serum deprivation, normal cells enter a Q state, but cells infected with the ts-mutant occupy an A state. (2) Whereas normal cells can occupy either state depending on culture conditions, the ts-infected cells, at 41.5 C, do not seem to enter Q even though a known src gene ...

1980-07-01

215

Calculation of radon flux attenuation by earthen uranium mill tailings covers

This report describes the fiscal 1998 result on development of genome informatics technology. As comparative analysis technique of genes, the combination of electrophoresis and PCR was used. For improvement of the throughput and reproducibility of the technique, module- shuffling primers were used, and the multi(96)-arrayed capillary fragment analyzer was devised. The system detecting SNPs rapidly was also developed successfully. As analysis technology of DNA sequence by use of triple- stranded DNA formation, study was made on construction of long cDNA libraries, selective subtraction of specific sequences from libraries, and the basic technology of homologous cloning. Study was also made on each reaction step of IGCR technique for fast analysis, and specifications of a fluorescence transfer monitor. As modeling technique of genetic sequence information, the simulation model was developed for gene expression regulatory networks during muscle differentiation, and ...

1999-03-01

216

Calculation of radon flux attenuation by earthen uranium mill tailings covers

This regulatory guide describes methods acceptable to the NRC staff for calculating radon fluxes through earthen covers and for calculating the resulting minimum cover thickness needed to meet NRC and EPA standards. The guide also suggests methods for obtaining the various parameters used in calculating the radon fluxes and earthen cover thicknesses and suggests default values for certain parameters. This regulatory guide is applicable to active uranium tailings sites. The NRC staff is using the methods stated in this guide as a basis for review and concurrence of DOE remedial action plans for inactive sites. The guidance is intended to be used for calculating radon flux attenuation by earthen uranium mill tailings covers. The parameter values and examples presented are limited to earthen cover materials, but the diffusion theory and the methods presented are also applicable to man-made materials. Detailed supporting information for calculating ...

2002-02-24

217

BWR stability analysis at Brookhaven National Laboratory

This regulatory guide describes methods acceptable to the NRC staff for calculating radon fluxes through earthen covers and for calculating the resulting minimum cover thickness needed to meet NRC and EPA standards. The guide also suggests methods for obtaining the various parameters used in calculating the radon fluxes and earthen cover thicknesses and suggests default values for certain parameters. This regulatory guide is applicable to active uranium tailings sites. The NRC staff is using the methods stated in this guide as a basis for review and concurrence of DOE remedial action plans for inactive sites. The guidance is intended to be used for calculating radon flux attenuation by earthen uranium mill tailings covers. The parameter values and examples presented are limited to earthen cover materials, but the diffusion theory and the methods presented are also applicable to man-made materials. Detailed supporting information for calculating ...

1989-06-01

218

Application of LBB to high energy pipings of PWR in Korea

Following the unexpected, but safely terminated, power and flow oscillations in the LaSalle-2 Boiling Water Reactor (BWR) on March 9, 1988, the Nuclear Regulatory Commission (NRC) Offices of Nuclear Reactor Regulation (NRR) and of Analysis and Evaluation of Operational Data (AEOD) requested that the Office of Nuclear Regulatory Research (RES) carry out BWR stability analyses, centered around fourteen specific questions. Ten of the fourteen questions address BWR stability issues in general and are dealt with in this paper. The other four questions address local, out-of-phase oscillations and matters of instrumentation; they fall outside the scope of the work reported here. It was the purpose of the work documented in this report to answer ten of the fourteen NRC-stipulated questions. Nine questions are answered by analyzing the LaSalle-2 instability and related BWR transients with the BNL Engineering Plant Analyzer (EPA) and by performing an ...

1991-12-31

219

Washington: a guide to geothermal energy development

The application of the LBB technology to the newly constructed PWRs has been approved in Korea for several high energy systems that can meet rigorous acceptance criteria. The LBB evaluation had been initiated for Yong-Gwang 3 and 4 units (YGN 3 and 4) which are in service, and subsequently performed for Ul-Chin 3 and 4 units (UCN 3 and 4) which are in construction. The LBB application in Korea is based on the USNRC requirements. The LBB evaluation for YGN 3 and 4 is to eliminate the dynamic effects associated with the postulated DEGB from design basis loads as well as to eliminate pipe whip restraints and jet impingement barriers. There were several issues on the application of LBB to the primary coolant loop and the pressurizer surge line. Of concern were material properties of carbon steel for the primary coolant loop, estimation of crack opening area at the pipe-to-nozzle interface considering the asymmetry, and the leakage crack size which barely meets the required margin of 2 in ...

1996-12-31

220

Vienna convention for the protection of the ozone layer. House of Representatives, One Hundredth Congress, First Session, June 22, 1987

A brief overview is given of the geological characteristics of each region of the state as they relate to potential geothermal development. Those exploration methods which can lead to the siting of a deep exploration well are described. Requirements and techniques needed for drilling deeper higher temperature exploration and production wells are presented. Electrical generation, direct utilization, and indirect utilization are reviewed. Economic factors of direct use projects are presented. A general guide to the regulatory framework affecting geothermal energy development is provided. The general steps necessary to gain access to explore, develop, distribute, and use geothermal resources are outlined. (MHR)

1980-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

221

Use of Behaviorally Anchored Rating Scales (BARS) for deep technical knowledge

The House Committee report describes the purpose, background, committee considerations and findings, and correspondence relating to H. Con. Res. 50, which is intended to encourage the president to pursue international negotiations relating to the ozone layer. The intent is to develop an international protocol and regulatory framework that will protect the stratosphere from the effects of chlorofluorocarbons. The report notes that some nations have already taken unilateral remedial steps, but argues the benefits of a negotiated agreement worldwide.

1987-01-01

222

Up in smoke: regulatory immortality for 'grandfathered' power plants under the NSR rule changes

The University of California at Los Angeles (UCLA) participated in a U.S. Nuclear Regulatory Commission research program to investigate methods to measure the effect of management and organization on nuclear plant safety. The UCLA research team focused its efforts on understanding {open_quotes}deep technical knowledge,{close_quotes} and its relation to probabilistic risk assessment. As a result, the research team combined deep technical knowledge with a commonly used rating system for understanding the effectiveness of management and organizations.

1993-12-31

223

Trends in Neuroendocrinology

The US New Source Review (NSR) program requires power plant owners to install modern pollution control whenever they upgrade their plants in a way that will cause more pollution. The Clean Air Task Force and other environmental organizations and dozens of states and municipalities have challenged changes to the NSR rule change exempting grandfathered power plants under certain conditions. The author discussed this legislation and whether the Clear Skies Act will be effective. 9 refs.

2004-01-01

224

British Library Electronic Table of Contents (United Kingdom)

The mammalian circadian timing system is organized into hierarchical structures with a central clock in the suprachiasmatic nucleus (SCN) and subsidiary peripheral oscillators. After the discovery of the local clockwork in peripheral organs and tissues, which have a molecular makeup similar to the central pacemaker SCN, uncovering the roles of the peripheral clock in the rhythmic physiology has been an emerging goal in chronobiology. Glucocorticoid (GC) is a multifunctional adrenal steroid hormone that shows a robust circadian rhythm. The daily GC rhythm has long been thought to be governed by the SCN via the hypothalamus-pituitary-adrenal neuroendocrine axis. Recent findings, however, indicate that multiple regulatory mechanisms, including the adrenal intrinsic mechanism by the peripheral...

2011-01-01

225

The day the sky caught fire

The day the sky caught fire

The author describes the history of the Soviet Unions nuclear weapons testing in Siberia from the first bomb on 29th August 1949 until the test-ban treaty of 1963. The effects of the weapons testing on the local population is only now becoming widely known. Levels of cancers and cataracts are significantly higher than in uneffected populations, and there are also high levels of some lung, bone, skin and digestive conditions. Perhaps the most important information relates to cataracts, previously thought to be caused by single large bursts of radiation. Regulatory authorities worldwide will need to tighten the safety limits for eye radiation exposure to these findings. (U.K.).

1995-05-13

226

The AECL's research reactor analysis methodology

The author describes the history of the Soviet Unions nuclear weapons testing in Siberia from the first bomb on 29th August 1949 until the test-ban treaty of 1963. The effects of the weapons testing on the local population is only now becoming widely known. Levels of cancers and cataracts are significantly higher than in uneffected populations, and there are also high levels of some lung, bone, skin and digestive conditions. Perhaps the most important information relates to cataracts, previously thought to be caused by single large bursts of radiation. Regulatory authorities worldwide will need to tighten the safety limits for eye radiation exposure to these findings. (U.K.).

1949-08-01

227

Telephone: it will never be the same

As the cost of developing completely new computer codes becomes prohibitive, designers of nuclear facilities are turning to more cost-effective approaches for meeting increasingly strict regulatory requirements applied to safety-related analysis. For designing and licensing the MAPLE family of research reactors, Atomic Energy of Canada Ltd. (AECL) is employing the strategy of adapting major existing codes by linking them together within networks of custom-built interface software. This approach builds on the international investment in developing, maintaining, and verifying existing primary codes and focuses on the less onerous development of interface codes. The resultant code systems are then validated for the new applications of interest.

228

Systems analysis of the CANDU 3 Reactor

A respected veteran among state utility regulators raises a sober warning that it may not be possible for the telecommunications industry to survive half regulated and half unregulated, which is its posture for the present. He foresees a danger that the unregulated sector may be successful in capturing all the profitable portions of the market, leaving only the unprofitable areas to the regulated sector, which will then experience serious dislocations and even system breakdowns. Avoidance of such an outcome to the deregulatory steps presently being taken will require an uncommon degree of prudence and wisdom in those state officials who remain charged with regulatory responsibility for local exchange telephone facilities and service.

1983-04-14

229

Standardization/improvement and technical development of light water reactor power station in Japan(BWR)

This report presents the results of a systems failure analysis study of the CANDU 3 reactor design; the study was performed for the US Nuclear Regulatory Commission. As part of the study a review of the CANDU 3 design documentation was performed, a plant assessment methodology was developed, representative plant initiating events were identified for detailed analysis, and a plant assessment was performed. The results of the plant assessment included classification of the CANDU 3 event sequences that were analyzed, determination of CANDU 3 systems that are ''significant to safety,'' and identification of key operator actions for the analyzed events.

230

Spent Fuel Transportation Package Response to the Baltimore Tunnel Fire Scenario

In order to realize improve of reliability and economy by duplicate production, rapid supply of repair parts from standardized storage, such were expected as to have continuous order of standardized plant, to ignore site condition, to avoid expansion of regulatory requirement. Standardization program was planned to limitedly promote standardization of safety-related design concept, major specification and basic system composition of reactor and primary systems. The area of standardization had been tried to expand to BOP such as general arrangement and rad-waste system.

1985-07-01

231

Southern receiver system: Environmental impact assessment status report: Conawapa to Winnipeg Power Transmission Complex

On July 18, 2001, a freight train carrying hazardous (non-nuclear) materials derailed and caught fire while passing through the Howard Street railroad tunnel in downtown Baltimore, Maryland. The United States Nuclear Regulatory Commission (USNRC), one of the agencies responsible for ensuring the safe transportation of radioactive materials in the United States, undertook an investigation of the train derailment and fire to determine the possible regulatory implications of this particular event for the transportation of spent nuclear fuel by railroad. Shortly after the accident occurred, the USNRC met with the National Transportation Safety Board (NTSB, the U.S. agency responsible for determining the cause of transportation accidents), to discuss the details of the accident and the ensuing fire. Following these discussions, the USNRC assembled a team of experts from the National Institute of Standards and Technology (NIST), the Center for ...

2006-11-01

232

Small power production case study: Montello hydroelectric plant, Montello, Wisconsin

The Conawapa-Winnipeg Power Transmission Complex includes five interrelated transmission and conversion facilities. This booklet describes work done on the upgrade of the southern receiver system, one component of the complex. The southern receiver system is composed of a network of high voltage transmission lines and station facilities. The booklet includes a description of the upgrade, the project setting, short and long-term effects and impact management, and the next steps to be taken in the process, including the regulatory process and public consultation.

1992-01-01

233

Seismic Design of Korean Next Generation Reactor

A case study of a small-scale hydroelectric plant to identify implementation problems is presented. The Montello hydroelectric plant is described including the background and history of the plant, the physical characteristics, the financial history and costs, operation, regulatory agencies, and the problems encountered in its operation. The analyses of the energy and capacity (demand) credits for the Montello hydroelectric plant when it is added to the Wisconsin Power and Light Company generating system is described. The WP and L base case and the results of the analyses are discussed. (WHK)

1980-11-01

234

Savannah River Site dose control

The objective of the Korean Next Generation Reactor(KNGR) seismic design is to develop a standard design that can cover most of site characteristics in the world with the possible exception of areas of high seismicity. This seismic design was based on the current state-of-the-art as well as the current Nuclear Regulatory guidance. This paper provides a summary on the design parameters used in the KNGR seismic design. In addition, this paper discusses seismic design requirements, selection of generic soil sites, selection of design control motions, and soil-structure interaction(SSI) analyses for the KNGR Nuclear Island(NI) structures. (author). 16 refs., 8 figs.

1999-07-01

235

Savannah River Site dose control

Health physicists from the Brookhaven National Laboratory (BNL) visited the Savannah River Site (SRS) as one of 12 facilities operated by the Department of Energy (DOE) contractors with annual collective dose equivalents greater than 100 person-rem (100 person-cSv). Their charter was to review, evaluate and summarize as low as reasonably achievable (ALARA) techniques, methods and practices as implemented. This presentation gives an overview of the two selected ALARA practices implemented at the SRS: Administrative Exposure Limits and Goal Setting. These dose control methods are used to assure that individual and collective occupational doses are ALARA and within regulatory limits.

1992-01-01

236

Safety design guide for pipe rupture protection for CANDU 9

Health physicists from the Brookhaven National Laboratory (BNL) visited the Savannah River Site (SRS) as one of 12 facilities operated by the Department of Energy (DOE) contractors with annual collective dose equivalents greater than 100 person-rem (100 person-cSv). Their charter was to review, evaluate and summarize as low as reasonably achievable (ALARA) techniques, methods and practices as implemented. This presentation gives an overview of the two selected ALARA practices implemented at the SRS: Administrative Exposure Limits and Goal Setting. These dose control methods are used to assure that individual and collective occupational doses are ALARA and within regulatory limits.

1992-06-01

237

Role and responsibilities of Technical Support Division (TSD) of National Nuclear Safety Department (NNSD) in licensing process

This safety design guide for pipe rupture protection identifies high-energy systems in which pipe ruptures must be postulated to occur, as well as systems that must be protected from the dynamic effects of such ruptures. Dynamic effects considered in this SDG consist of pipe whip (including missiles generated by pipe ruptures, if any) and jet impingement, Requirements for protection against the dynamic effects of a postulated pipe rupture and method of protection of essential structures, systems and components are specified for these effects. The change status for the regulatory requirements, code and standards should be traced and this safety design guide shall be updated accordingly. 2 tabs., 5 refs. (Author) .new.

1996-03-01

238

Reciprocal regulation of the neural and innate immune systems

National Nuclear Safety Department is authorized by Infra (Iranian Nuclear Regulatory Authority) for issuing rules and regulation and conducting the licensing and supervisory process for nuclear facilities. The main responsibilities of the NNSD are conducted via five main division are, nuclear codes and standards, Nuclear Safety assessment, Authorization, Inspection and Enforcement and Technical Support. In this paper, the functions and responsibilities of TSD in enhancing nuclear safety are described. Examples of main tasks to support the Nuclear Safety assessment division regarding to technical calculations and research of safety issues in licensing documents are provided. (author)

2007-08-01

239

British Library Electronic Table of Contents (United Kingdom)

Innate immune responses are regulated by microorganisms and cell death, as well as by a third class of stress signal from the nervous and endocrine systems. The innate immune system also feeds back, through the production of cytokines, to regulate the function of the central nervous system (CNS), and this has effects on behaviour. These signals provide an extrinsic regulatory circuit that links physiological, social and environmental conditions, as perceived by the CNS, with transcriptional 'decision-making' in leukocytes. CNS-mediated regulation of innate immune responses optimizes total organism fitness and provides new opportunities for therapeutic control of chronic infectious, inflammatory and neuropsychiatric diseases.

2011-01-01

240

Radiological protection. Textbook for radiographers and reference book for radiological safety officers

Proceedings: symposium on flue gas desulfurization. Volume I

The textbook is primarily intended for radiologic staff and radiologic safety officers and gives information on the current regulatory provisions of the German X-ray Ordinance, applications of X-rays, quality assurance, organisational aspects of film processing and quality requirements of X-rays. An annex lists the guidelines of the Bundesaerztekammer (German National Chamber of Physicians) relating to quality assurance aspects, and further useful information on commercially available film-screen systems, the various associations of physicians in Germany, and requirements and performance of radiation surveys. (vhe).

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

241

Proceedings of the third international conference on containment design and operation. v.1

The proceedings document the presentations made during the symposium, which dealt with the status of flue gas desulfurization technology in the United States and abroad. Subjects considered included: regenerable, non-regenerable, and advanced processes; process costs; and by-product disposal, utilization, and marketing. The purpose of the symposium was to provide developers, vendors, users and those concerned with regulatory guidelines with a current review of progress made in applying processes for the reduction of sulfur dioxide emissions at the full- and semi-commercial scale. The 20 papers were abstracted and indexed separately.

1976-05-01

242

Performance Testing Methodology for Safety-Critical Programmable Logic Controller

The second international conference on containment design and operation included sessions on the following topics: performance and regulatory requirements; radionuclide behaviour; severe accident design and analysis; operation, maintenance, leaking and aging of containment systems; thermal hydraulic behaviour of containment systems; hydrogen mixing and mitigation; design methods and concepts; code validation; structural analysis and response tests; passive safety systems; aerosol behaviour; containment reliability, integrity, and risk assessment; hydrogen deflagration and detonation. Due prominence was given to CANDU and other PHWR reactors. The individual papers have been abstracted separately.

1994-10-19

243

National Oil Shale Leasing Act of 1981. [Report submitted by Sen. McClure to accompany S. 1484

The Programmable Logic Controller (PLC) for use in Nuclear Power Plant safety-related applications is being developed and tested first time in Korea. This safety-related PLC is being developed with requirements of regulatory guideline and industry standards for safety system. To test that the quality of the developed PLC is sufficient to be used in safety critical system, document review and various product testings were performed over the development documents for S/W, H/W, and V/V. This paper provides the performance testing methodology and its effectiveness for PLC platform conducted by KOPEC

2009-05-01

244

NRC safety research priorities for reactor vessel embrittlement, annealing, and surveillance dosimetry

S. 1484 is intended to change the oil-shale-leasing provisions of the Mineral Leasing Act of 1920 to encourage development of oil-shale resources on federal and non-federal lands. It authorizes the Secretary of the Interior to lease land for mining and additional land for waste-disposal and construction facilities. The text of S. 1484 is followed by the background and legislative history of the bill, a section-by-section analysis of the bill, and an evaluation of its budgetary and regulatory impacts. Pertinent communications are reprinted with recommendations and additional views. (DCK)

1981-01-01

245

Low Power and Shutdown Risk Assessment Benchmarking Study

The recent definition of a postulated thermal shock accident followed promptly by system repressurization, termed an overcooling or pressurized thermal shock accident, has set a large analysis and research effort into motion. The essential elements are concerned with defining the accident transients, evaluating the instrumentation and controls that cause the postulated accidents, and evaluating the metallurgical and structural mechanics aspects of the reactor vessel with respect to its failure potential. This paper poses the question faced by the Nuclear Regulatory Commission (NRC) for the vessel steel embrittlement, annealing, and surveillance dosimetry facets of this postulated accident and provides information on our plans for study of this problem as well as current status.

1981-10-01

246

Low Power and Shutdown Risk Assessment Benchmarking Study

(B204)Probabilistic risk assessment (PRA) insights are now used by the United States Nuclear Regulatory Commission (USNRC) to confirm the level of safety for plant operations and to justify changes in nuclear power plant operating requirements, both on an exception basis and as changeds to a plant's licensing basis. This report examines qualitative and quantitative risk assessments during shutdown plant states, providing feedback to utilities in the use of qualitative models for outage risk management, and also providing input to the development of the American Nuclear Society (ANS) Low Power and Shutdown PRA Standard.

2002-12-15

247

Land And Water Use Characteristics And Human Health Input Parameters For Use In Environmental Dosimetry And Risk Assessments At The Savannah River Site

(B204)Probabilistic risk assessment (PRA) insights are now used by the United States Nuclear Regulatory Commission (USNRC) to confirm the level of safety for plant operations and to justify changes in nuclear power plant operating requirements, both on an exception basis and as changeds to a plant's licensing basis. This report examines qualitative and quantitative risk assessments during shutdown plant states, providing feedback to utilities in the use of qualitative models for outage risk management, and also providing input to the development of the American Nuclear Society (ANS) Low Power and Shutdown PRA Standard.

2002-12-15

248

Interpreting Mammalian Evolution using Fugu Genome Comparisons

Operations at the Savannah River Site (SRS) result in releases of small amounts of radioactive materials to the atmosphere and to the Savannah River. For regulatory compliance purposes, potential offsite radiological doses are estimated annually using computer models that follow U.S. Nuclear Regulatory Commission (NRC) Regulatory Guides. Within the regulatory guides, default values are provided for many of the dose model parameters but the use of site-specific values by the applicant is encouraged. A detailed survey of land and water use parameters was conducted in 1991 and is being updated here. These parameters include local characteristics of meat, milk and vegetable production; river recreational activities; and meat, milk and vegetable consumption rates as well as other human usage parameters required in the SRS dosimetry models. In addition, the preferred elemental bioaccumulation factors and ...

249

Interest of a two-dimensional matrix of detectors for the quality control of beams in static or dynamic mode; Interet d'une matrice bidimensionnelle de detecteurs pour le controle de qualite des faisceaux en mode statique ou dynamique

Comparative sequence analysis of the human and the pufferfish Fugu rubripes (fugu) genomes has revealed several novel functional coding and noncoding regions in the human genome. In particular, the fugu genome has been extremely valuable for identifying transcriptional regulatory elements in human loci harboring unusually high levels of evolutionary conservation to rodent genomes. In such regions, the large evolutionary distance between human and fishes provides an additional filter through which functional noncoding elements can be detected with high efficiency.

2004-04-02

250

Identification and characterization of wetlands in the Bear Creek watershed

A 2D matrix allows a fairly rapid verification of irradiation parameters transferred on computer processing equipment without expanding the dosimetry means to implement. Associated to 'Multicheck and Verisoft' software it will handle some of the regulatory recommendations of the A.F.S.S.A.P.S. for quality control of accelerators and ensure the traceability of testing carried out. (N.C.)

2007-11-15

251

Hydrothermal industrialization electric-power systems development. Final report

The primary objective of this study was to identify, characterize, and map the wetlands in the Bear Creek watershed. A preliminary wetland categorization system based on the Cowardin classification system (Cowardin et al. 1979) with additional site-specific topographic, vegetation, and disturbance characteristic modifiers was developed to characterize the type of wetlands that exist in the Bear Creek watershed. An additional objective was to detect possible relationships among site soils, hydrology, and the occurrence of wetlands in the watershed through a comparison of existing data with the field survey. Research needs are discussed in the context of wetland functions and values and regulatory requirements for wetland impact assessment and compensatory mitigation.

1993-10-01

252

How the Energy and Water Development Appropriations Act of 1993 has impacted the constitutional dynamics of federal wetlands delineation and regulation

The nature of hydrothermal resources, their associated temperatures, geographic locations, and developable capacity are described. The parties involved in development, required activities and phases of development, regulatory and permitting requirements, environmental considerations, and time required to complete development activities ae examined in detail. These activities are put in proper perspective by detailing development costs. A profile of the geothermal industry is presented by detailing the participants and their operating characteristics. The current development status of geothermal energy in the US is detailed. The work on market penetration is summarized briefly. Detailed development information is presented for 56 high temperature sites. (MHR)

1982-03-01

253

High voltage transmission lines - what are the hazards

A reliable source of specific criteria for recognizing a wetland, as defined for regulatory purposes would be valuable. In 1987 the Army Corps of Engineers developed a technical manual for identifying wetlands (1987 Wetlands Manual). An interagency manual (1989 Wetlands Manual) was later developed. This manual has been used to identify wetlands according to three evidentiary factors: vegetation, hydrology, and soil. This paper addresses the development of criteria to delineate wetlands, and describes some of the logic used by federal courts to uphold the limited constitutional use of the 1989 Wetlands Manual.

1995-12-31

254

Hanford Federal Facility Agreement and Consent Order quarterly progress report for the period ending June 30, 1991

With the increasing use of high voltage alternating current (HVAC) transmission lines there is a growing concern among the public about possible human health effects resulting from exposure to the electric fields associated with these lines. While there is no definitive evidence of such effects, mounting public fear and activism over hypothesized health risks is already causing delays in the licensing and constuction of major power transmission facilities, and is encouraging the formation of regulatory policy. This paper briefly reviews the concerns, biological effects data and standards for HVAC transmission lines.

1984-07-01

255

Full-length fuel rod behavior under severe accident conditions

This is the ninth quarterly report as required by the Hanford Federal Facility Agreement and Consent Order (Ecology et al. 1990), also known as the Tri-Party Agreement, established between the US Department of Energy (DOE), the US Environmental Protection Agency (EPA), and the Washington State Department of Ecology (Ecology). The Tri-Party Agreement sets the plan and schedule for achieving regulatory compliance and cleanup of waste sites at the Hanford Site. This report covers progress for the quarter that ended June 30, 1991. A total of 87 milestones have been completed to date. 39 refs., 1 fig.

1991-08-01

256

Fourth international seminar on horizontal steam generators

This document presents an assessment of the severe accident phenomena observed from four Full-Length High-Temperature (FLHT) tests that were performed by the Pacific Northwest Laboratory (PNL) in the National Research Universal (NRU) reactor at Chalk River, Ontario, Canada. These tests were conducted for the US Nuclear Regulatory Commission (NRC) as part of the Severe Accident Research Program. The objectives of the test were to simulate conditions and provide information on the behavior of full-length fuel rods during hypothetical, small-break, loss-of-coolant severe accidents, in commercial light water reactors.

1992-12-01

257

First-generation price-squeeze policy at the FERC

The general objective of the International Seminars of Horizontal Steam Generator Modelling has been the improvement in understanding of realistic thermal hydraulic behaviour of the generators when performing safety analyses for VVER reactors. The main topics presented in the fourth seminar were: thermal hydraulic experiments and analyses, primary collector integrity, feedwater distributor replacement, management of primary-to-secondary leakage accidents and new developments in the VVER safety technology. The number of participants, representing designers and manufacturers of the horizontal steam generators, plant operators, engineering companies, research organizations, universities and regulatory authorities, was 70 from 10 countries.

1997-12-31

258

Financial and operating implications of economic depreciation. Potential responses by financial institutions and markets

A 1976 decision of the US Supreme Court made it clear that the Federal Energy Regulatory Commission (then the Federal Power Commission) has a responsibility to consider and determine allegations that proposed wholesale electric rates create a price squeeze against customers who compete with the wholesaler in making retail electric sales. This article reviews how the commission has approached the matter of discharging its newly recognized responsibility since that time, and describes its current position regarding the several issues and questions that price squeeze allegations raise. 35 references.

1982-09-30

259

Electric field exposure from electric blankets

Economic depreciation of similar cost recovery schemes delay cash return of investment. Such delay may require new types of securities. Due to uncertainty of regulatory action and technology over the prolonged recovery life of the projects, investors may require a higher return, thereby raising the cost of capital. Utility managements might eschew long lived investment, too, even if cost effective to the consumer. Alternatives exist that would approximate the price signals of economic depreciation without discouraging investment. The importance of upfront returns to the investment process should not be minimized. 2 figs., 3 refs. (AV)

1985-03-01

260

Control Rod Ejection Accident while Using 6- and 8-Tube IRT-4M Fuel Assemblies in WWR-SM Research Reactor Core

Comparisons of the 60 Hz electric field exposures associated with high voltage transmission lines to those associated with common household sources can provide an important input to regulatory decisions that involve transmission line fields. Electric blankets are of interest in this context because the exposures they produce are among the most intense and prolonged of any of the household sources of 60 Hz electric field exposure. This paper presents a theoretical analysis of the body surface fields induced by electric blankets. Electric blanket exposure intensities are compared to those associated with transmission lines.

1987-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

261

Contract pricing of electric and telephone service: Current practice and policy

The WWR-SM reactor at the Institute of Nuclear Physics of the Academy of Sciences (INP AS) in Uzbekistan was converted to 6-tube IRT-4M LEU (19.7%) fuel in 2009. Presently, INP intends to also use IRT-4M 8-tube FA, and a safety analysis for these 'mixed' (8-tube and 6-tube FA) cores is required by the regulatory authorities. This paper presents results of control rod ejection transient analysis for these mixed cores

2011-07-01

262

Comparison of Atmospheric Dispersion Models Between PHWR and PWR

Due mainly to competitive pressures, the practice of offering electric and telephone service under contracts or special tariffs negotiated individually between a utility and its customers has increased in importance in recent years. Moreover, the practice is likely to become still more widespread in the future. This creates questions of public policy that are of interest to regulators and ratepayers alike such as how to supervise the practice, how to encourage utilities to compete while preventing cross-subsidization and anticompetitive behavior, and how the practice will ultimately affect utilities and ratepayers. This report sheds light on the topic by describing approaches that have been taken by the various regulatory commissions and by providing a framework for analyzing such contractors.

1992-04-01

263

Cogeneration and beyond: The need and opportunity for high efficiency, renewable community energy systems

The radiation dose and the atmospheric dispersion for Pressurized Heavy Water Reactors (PHWR) are based on the CAN/CSA N288.2-M91 standards: for Pressurized Water Reactor (PWR) on the NRC Regulatory Guide 1.145. There are some differences between in the methodologies used in the standards, including the atmospheric dispersion model, the release height, the temperature lapse rate, the cutoff condition. This paper reports on a comparison of standards for atmospheric dispersion models of PHWRs and PWRs in order to determine which one is the more conservative. The comparison between PHWR and PWR for atmospheric dispersion factors and radiation doses confirms that there are no big differences

2010-10-01

264

Analysis of potential self-guarantee tests for demonstrating financial assurance by non-profit colleges, universities, and hospitals and by business firms that do not issue bonds

The justification, strategies, and technology options for implementing advanced district heating and cooling systems in the United States are presented. The need for such systems is discussed in terms of global warming, ozone depletion, and the need for a sustainable energy policy. Strategies for implementation are presented in the context of the Public Utilities Regulatory Policies Act and proposed new institutional arrangements. Technology opportunities are highlighted in the areas of advanced block-scale cogeneration, CFC-free chiller technologies, and renewable sources of heating and cooling that are particularly applicable to district systems.

2007-10-15

265

Alaska: a guide to geothermal energy development

The Nuclear Regulatory Commission (NRC) on December 29, 1993, promulgated self-guarantee requirements that materials licensees may use to demonstrate financial assurance for decommissioning costs. However, nonprofit colleges and universities, nonprofit hospitals, and for-profit firms that do not issue bonds are currently precluded, by their unique accounting and financial reporting systems, or by other features of their business practices, from using the financial tests for self-guarantors adopted by the NRC. This Report evaluates several alternative financial tests that might serve as the basis for self-guarantee by these three categories of licensees.

1997-06-01

266

A study for good regulation of the CANDU's in Korea

A brief overview is given of the geological characteristics of each region of the state as they relate to potential geothermal development. Those exploration methods which can lead to the siting of a deep exploration well are described. Requirements and techniques needed for drilling deeper higher temperature exploration and production wells are presented. Electrical generation, direct utilization, and indirect utilization are reviewed. Economic factors of direct use projects are presented. A general guide to the regulatory framework affecting geothermal energy development is provided. The general steps necessary to gain access to explore, develop, distribute, and use geothermal resources are outlined. (MHR)

1980-06-01

267

A Preliminary Analysis of SMART Reactor Core Using the COREDAX Code

The objective of project is to derive the policy recommendations to improve the efficiency of CANDU plants regulation. These policy recommendations will eventually contribute to the upgrading of Korean nuclear regulatory system and safety enhancement. During the second phase of this 2 years study, following research activities were done. Review the technical basis and framework of the new Canadian Regulation System and IAEA. Analysis on the interview of Wolsung operation staffs to identify important safety issues and regulation problems experienced at operation. Providing a plan of CANDU regulation system enhancement program.

2002-03-15

268

Spent fuel transportation cask response to a tunnel fire scenario

The 3-D neutronics code COREDAX has been developed based on AFEN (Analytic Function Expansion Nodal) method for x-y-z geometry and for hex-z geometry. In this study, the COREDAX code, as a regulatory review tool independent of the designer's, was applied to the SMART reactor core that was designed by KAERI (Korea Atomic Energy Research Institute). For nuclear cross section generation, the HELIOS lattice code was used in this study. The preliminary results for steady state in various conditions are presented in this paper

2010-10-01

269

Savannah River Site production reactor safety analysis report. K production reactor

On July 18, 2001, a freight train carrying hazardous (non-nuclear) materials derailed and caught fire while passing through the Howard Street railroad tunnel in downtown Baltimore, Maryland. The United States Nuclear Regulatory Commission (USNRC), one of the agencies responsible for ensuring the safe transportation of radioactive materials in the United States, undertook an investigation of the train derailment and fire to determine the possible regulatory implications of this particular event for the transportation of spent nuclear fuel by railroad. Shortly after the accident occurred, the USNRC met with the National Transportation Safety Board (NTSB), the U.S. agency responsible for determining the cause of transportation accidents, to discuss the details of the accident and the ensuing fire. Following these discussions, the USNRC assembled a team of experts from the National Institute of Standards and Technology (NIST), the Center for ...

2004-07-01

270

Regulatory experience on safety system instrument uncertainty of Wolsong units

Nuclear facilities of the Department of Energy (DOE) located at the Savannah River Site must comply with DOE orders as implemented at DOE-SR. The DOE orders cover safety criteria, design criteria, environmental protection, occupational health and safety. The program applies to DOE and contractors. In this section, the Nuclear Regulatory Commission (NRC) criteria and industry codes and standards are addressed as well as DOE orders. Specific DOE orders which add additional criteria have also been noted. A program for assessing and implementing contractor applicable DOE orders has been established. This program ensures that compliance is achieved through developing and implementing policies, programs, and procedures. The primary emphasis is placed on safe, efficient reactor restart and operation. DOE has classified orders applicable to restart as Level I, Category I while those applicable to post-restart are classified as Level I, Category II. Category I and II orders ...

271

Innovative approach for restoring coastal wetlands using treated drill cuttings

This paper presents the regulatory experience gained from Wolsong Units 2,3 and 4 - Special Safety System Instrumentation Uncertainty for Trip Setpoint and Allowable Values. The equipment diversity method for the defense against common mode failure was applied to the transmitters of shutdown system number 2. However the Units experienced an unexpected drift problem with which the performance did not meet the Technical Specification (Tech Spec) Surveillance Requirements (SR). Discussed are the background, status and corrective actions, regulatory positions and issues to be solved for the drift problem. It was an instrument uncertainty methodology that the designer of safety system should have shown when the drift problem occurred. For deeper understanding of the problem, we present the background of Tech Spec SR for setpoints in Korean PWR and in CANDU reactors. The Setpoint Verification Test(SVT) and Calibration Test(CT) shall be achieved by ...

2001-05-01

272

In vivo footprinting of the human [alpha]-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction

The leading environmental problem facing coastal Louisiana regions is the loss of wetlands. Oil and gas exploration and production activities have contributed to wetland damage through erosion at numerous sites where canals have been cut through the marsh to access drilling sites. An independent oil and gas producer, working with Southeastern Louisiana University and two oil field service companies, developed a process to stabilize drill cuttings so that they could be used as a substrate to grow wetlands vegetation. The U.S. Department of Energy (DOE) funded a project under which the process would be validated through laboratory studies and field demonstrations. The laboratory studies demonstrated that treated drill cuttings support the growth of wetlands vegetation. However, neither the Army Corps of Engineers (COE) nor the U.S. Environmental Protection Agency (EPA) would grant regulatory approval for afield trial of the process. Argonne National Laboratory was ...

1999-11-02

273

Analysis of delta-ferrite data from production stainless steel pipe welds

A major regulatory element required for expression of the human [alpha]-globin genes is located 40 kb upstream of the embryonic [zeta]-globin gene. To understand how this and other locus control region (LCR) elements contribute to high-level expression in erythroid cells, we have performed high-resolution, in vivo dimethyl sulfate footprinting. In addition, we have modified the dimethyl sulfate-based ligation-mediated polymerase chain reaction in vivo footprinting procedure to permit the assessment of interactions at guanine and adenine residues, rather than guanines alone. In vivo footprinting of the human [alpha]-LCR element carried on chromosome 16 in a mouse erythroleukemia cell environment revealed protein occupancy at GATA-1, AP-1/NF-E2, and CACC/GGTGG motifs, specific differences compared with in vitro protein binding, and distinct changes in one region upon dimethyl sulfoxide-induced cellular maturation. No protein contacts were detected in nonexpressing ...

1992-05-01

274

A study on the regulatory approach of KNGR multiple failure events

An American Society of Mechanical Engineers task group on stainless steel weld materials was organized to determine the need for ferrite measurements of production welds required by the US Nuclear Regulatory Commission Regulatory Guide 1.31 (Rev. 1). The task group studied paired ferrite measurements (i.e., calculated and measured ferrite numbers (FNs) for the material qualifications versus measured ferrite numbers for corresponding production welds (PWs)). Our purpose was to compare delta-ferrite content as measured in the filler metal weld qualification pad with that in the resultant PW. Welds made predominantly by three common processes (submerged arc, shielded metal arc, and gas tungsten arc) were included in the study. Weld metals investigated included types 308, 308L, 316, and 316L stainless steel. An initial evaluation of the paired ferrite measurements was made by the task group, and specific conclusions and recommendations were made. ...

1984-01-01

275

A research of the development of electricity and natural gas markets and the experiences gained from implementation of the electricity and natural gas market laws

This project is to provide the regulatory direction of containment bypass during multiple steam generator tube failure issue for the Korean Next Generation Reactors, which is a part of major technical issues resulted from the safety regulation R and D on the KNGR. The outstanding results are as follows : the Multiple Steam Generator Tube Repture(MSGTR) event has never been occurred in the history of commercial nuclear reactor operation but single Steam Generator Tube Rupture(SGTR) event is reported to occur every two years. A probabilistic safety analysis study on MSGTR event, however, show its probability of occurrence is to be the same order as the design basis accidents such as LACA. In this regard, the ability of NPPs to cope with MSGTR event is required. Some requirements on initial and boundary conditions are suggested to be used in the analyses of NPPs during MSGTR events. The items that should be considered in establishing regulatory ...

2001-01-15

276

Proceedings of a specialist meeting on regulatory approaches for the control of environmental residues containing naturally occurring radioactive material. Working material

In the beginning of 2005 several changes in the electricity and natural gas market law came into effect. This report examines the influence and impact of these changes on the behaviour and development of these markets, looking at the role and position of both the energy industry and customers. The report combines existing data with new research data collected during spring and summer 2006. Whilst the recency of the law changes, along with the simultaneous impact of other market variables limits the salience of any impact, the report nevertheless provides clear and interesting conclusions. In the electricity market, one major legislative change that came into force in the beginning of 2005 concerned the supervision of the reasonableness of electricity distribution pricing. According to the newly adopted ex ante regulation principles, the regulatory authority now determines the guidelines for reasonable pricing prior the start of a predefined ...

277

Packaging Review Guide for Reviewing Safety Analysis Reports for Packagings

Naturally occurring radionuclides are present in most material. The most common naturally occurring radionuclides in material are those of the uranium and thorium series and potassium-40. This material is commonly referred to as Naturally Occurring Radioactive Material (NORM). In some material the levels of naturally occurring radionuclides are significantly higher, to the extent that regulatory control may be required for radiation protection purposes. Regulation of NORM presents a range of new challenges for both regulators and operators. Unlike more traditional industries dealing with radionuclides, NORM industries have generally not had any radiological oversight and, for example, are not equipped for radiological monitoring. Some consumer goods containing NORM, which have not traditionally been considered as a radiological problem (such as some fertilizers), may require regulation and this may have social and economic consequences. The transport and disposal ...

2002-09-23

278

Development of American National Standard on External Event PRA Methodology

This Packaging Review Guide (PRG) provides guidance for Department of Energy (DOE) review and approval of packagings to transport fissile and Type B quantities of radioactive material. It fulfills, in part, the requirements of DOE Order 460.1B for the Headquarters Certifying Official to establish standards and to provide guidance for the preparation of Safety Analysis Reports for Packagings (SARPs). This PRG is intended for use by the Headquarters Certifying Official and his or her review staff, DOE Secretarial offices, operations/field offices, and applicants for DOE packaging approval. This PRG is generally organized at the section level in a format similar to that recommended in Regulatory Guide 7.9 (RG 7.9). One notable exception is the addition of Section 9 (Quality Assurance), which is not included as a separate chapter in RG 7.9. Within each section, this PRG addresses the technical and regulatory bases for the review, the manner in ...

2007-04-12

279

Benchmarking of RESRAD-OFFSITE : transition from RESRAD (onsite) toRESRAD-OFFSITE and comparison of the RESRAD-OFFSITE predictions with peercodes.

During the last ten years, the U.S. Nuclear Regulatory Commission and the U.S. nuclear utilities have been developing methods and requirements for risk-informed applications making use of probabilistic risk assessments (PRA) of nuclear power plants. Early in this process, it became clear that the existing PRAs were done with different objectives and methodologies by different analysts. For uniformity and consistency in future risk-informed applications, industry consensus standards on probabilistic risk assessments were deemed to be essential. Currently, the following standards have been published or under preparation: - ASME RA-S-2002: 'Standard for Probabilistic Risk Assessment for Nuclear Power Plant Applications', Addendum C, March 2005. - ANSI/ANS-58.21-2003 'External-Events PRA Methodology' March 2003. - ANS-58.22 'Low Power and Shutdown PRA Standard'. - ANS-58.23 'Fire PRA Methodology Standard'. - ANS Level 2 and Level 3 PRA Standards. The ASME Standard ...

2007-11-14

280

[Functional state of the hypothalamo-hypophyseal-gonadal system in patients with chronic alcoholic intoxication].

The main purpose of this report is to document the benchmarking results and verification of the RESRAD-OFFSITE code as part of the quality assurance requirements of the RESRAD development program. This documentation will enable the U.S. Department of Energy (DOE) and its contractors, and the U.S. Nuclear Regulatory Commission (NRC) and its licensees and other stakeholders to use the quality-assured version of the code to perform dose analysis in a risk-informed and technically defensible manner to demonstrate compliance with the NRC's License Termination Rule, Title 10, Part 20, Subpart E, of the Code of Federal Regulations (10 CFR Part 20, Subpart E); DOE's 10 CFR Part 834, Order 5400.5, ''Radiation Protection of the Public and the Environment''; and other Federal and State regulatory requirements as appropriate. The other purpose of this report is to document the differences and ...

2006-05-22

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281

Wetlands: their use and regulation

The function of the hypothalamo-pituitary-gonadal system has been studied in 118 males with different stages of alcoholism. Comparison with the control group has shown decreased levels of interstitial cell stimulating hormone (ICSH), follicle-stimulating hormone (FSH), and testosterone, and elevated concentrations of prolactin (Prl). Differences in the parameters of hormonal activity expressed in a varying degree of a decrease in FSH, ICSH, and testosterone, and a Prl elevation are related to change in mutual regulatory influences between the gonads and hypothalamo-pituitary complex. The most informative parameters were concentrations of Prl and testosterone (considering elevation in the former and reduction in the latter hormone) and the ratio of their concentrations. Difference of these parameters in each group (corresponding to the stages of alcoholism) may be used as an additional diagnostic criterion of chronic alcohol intoxication. PMID:3434080

1987-01-01

282

Wetlands: Community and individual rights v. unchecked government power. Hearing before the Subcommittee on National Economic Growth, Natural Resources, and Regulatory Affairs of the Committee on Government Reform and Oversight, House of Representatives, One Hundred Fifth Congress, First Session, June 16, 1997

Although destruction of United States wetlands has slowed, their continued conversion, especially in certain inland regions of the country, may pose adverse ecological effects over the next few decades. The Army Corps of Engineers' regulatory program (Section 404 of the Clean Water Act) protects most coastal wetlands, but provides no protection for 95% of the country's wetlands which remain inland. These inland, freshwater wetlands, converted for agricultural purposes, comprise 80% of the wetland losses over the past 30 years. This report outlines options for more effective federal management, such as the mapping and categorizing of wetlands to determine relative values. In effect, agencies can focus protection programs on higher-value wetlands, especially those threatened by agricultural conversion. The report also discusses the contradictory federal policies aimed at wetlands; for example, the tax code encourages the development and draining of ...

1984-01-01

283

WIPS: computer code for whip and impact analysis of piping systems. Summary report

The purpose of this hearing was to bring to the public`s attention a better understanding of both the shortcomings as well as the benefits of the existing wetlands regulations programs, policies and regulations. In addition an attempt was made to highlight those areas where there have been problems with restrictive or confusing regulations, time delays, and costs involved. Ultimately, the purpose is to identify areas in the federal regulations, and if necessary in the federal wetlands related laws, that can be amended, so these work better.

1997-12-31

284

Utilities feel weight of burden caused by EMF fears

WIPS (Whip and Impact of Piping Systems) is a special purpose computer code for the structural analysis of pipe whip dynamic effects following a postulated pipe rupture. WIPS has been developed primarily to provide support for the pipe whip analysis procedures described in Section 3.6.2 of the US Nuclear Regulatory Commission Standard Review Plan. This report summarizes the purpose and scope of the WIPS development effort, identifying those clauses in the Standard Review Plan which refer to pipe whip analysis, and indicating how the WIPS code can be used to provide supporting data. Detailed information on use of the code is contained in accompanying reports which cover: (1) user instructions; (2) theory; (3) programming procedures; and (4) verification examples.

1984-06-01

285

Upsetting categories? The consequences of pharmacogenomics for making knowledge-based reimbursement decisions in Sweden

Studies on the effects of electromagnetic fields (EMF)on human health have been conducted for more than 20 years. None have categorically established or eliminated any connection between EMF and adverse health effects. Nonetheless, 96% of the risk managers working in the utility sector view EMF as an over-riding concern. Public concern over EMF has erupted into legal, as well as regulatory, actions. To date, some utilities have had lawsuits brought against them by customers who claim they developed cancer as a result of nearby high-voltage transmission lines. What`s more, a small handfull of cities have adopted ordinances that specifically limit where and how utilities handle the placement of their transmission lines.

1995-10-01

286

British Library Electronic Table of Contents (United Kingdom)

This paper contributes to an understanding of pharmacogenomics-in-the-making by foregrounding a regulatory setting in which these technologies must be situated: decision-making about pharmaceutical reimbursement. Health care assessment organizations have been introduced in many countries to systematically address the issue of health care coverage. Using the example of Sweden, the process of deciding reimbursement status is shown to hinge on the creation of stable and clinically feasible categories of patients, diseases and drug responses. Through a series of analogous examples concerning conventional pharmaceuticals, it is argued that current mechanisms for categorizing reimbursable drugs could be upset when pharmacogenomic advances provide a means of making patients more specific objects ...

2010-01-01

287

The use of long-term and seasonal trends of elemental compounds as an aid to the identification of sources of airborne pollutants

The use of long-term and seasonal trends of elemental compounds as an aid to the identification of sources of airborne pollutants

New York City data indicate that seasonal and annual variations in dispersion-normalized air pollutant concentrations appear to accurately reflect changes in source emission patterns. The normalized concentrations make it possible to observe the impact of regulatory changes on ambient air quality without these impacts being obscured by meteorological fluctuations. It is found that numerical modeling techniques and regression analysis can be powerful tools for extracting information from large sets of air quality data. The use of differential, as opposed to absolute, pollutant concentration values will reduce artifact correlations caused by seasonal, weekly, or daily meteorological fluctuations and will permit more accurate estimation of the regression coefficients. This technique was successfully applied to a set of daily pollution measurements whose absolute concentrations were found not to yield a statistically significant fit by multiple regression.

1980-01-01

288

The use of combinatorial topographical libraries for the screening of enhanced osteogenic expression and mineralization

New York City data indicate that seasonal and annual variations in dispersion-normalized air pollutant concentrations appear to accurately reflect changes in source emission patterns. The normalized concentrations make it possible to observe the impact of regulatory changes on ambient air quality without these impacts being obscured by meteorological fluctuations. It is found that numerical modeling techniques and regression analysis can be powerful tools for extracting information from large sets of air quality data. The use of differential, as opposed to absolute, pollutant concentration values will reduce artifact correlations caused by seasonal, weekly, or daily meteorological fluctuations and will permit more accurate estimation of the regression coefficients. This technique was successfully applied to a set of daily pollution measurements whose absolute concentrations were found not to yield a statistically significant fit by multiple regression.

289

British Library Electronic Table of Contents (United Kingdom)

Nano- and microstructured surfaces are known to impact on the binding and differentiation of cells, but the detailed basic understanding of the underlying regulatory mechanisms is still scarce, which impedes the rational design of smart biomaterials. Towards a comprehensive analysis of the interplay between topographical parameters such as feature design and lateral and vertical dimensions we here report on a combinatorial screening approach, BioSurface Structure Array (BSSA) of test squares each with a distinct topography. Using such BSSA libraries of 504 topographically distinct surface structures, we have identified combinations of size, gap and height of structures which enhance mineralization as well as the expression of osteogenic markers of a preosteoblastic murine cell line. This g...

2009-01-01

290

Technical considerations for flexible piping design in nuclear power plants

Tank 241-AZ-101 Mixer Pump Test Vapor Sampling and Analysis Plan

The overall objective of this research project is to develop a technical basis for flexible piping designs which will improve piping reliability and minimize the use of pipe supports, snubbers, and pipe whip restraints. The current study was conducted to establish the necessary groundwork based on the piping reliability analysis. A confirmatory piping reliability assessment indicated that removing rigid supports and snubbers tends to either improve or affect very little the piping reliability. A couple of changes to be implemented in Regulatory Guide (RG) 1.61 and RG 1.122 aimed at more flexible piping design were investigated. It was concluded that these changes substantially reduce calculated piping responses and allows piping redesigns with significant reduction in number of supports and snubbers without violating ASME code requirements.

1985-03-15

291

Synergies and conflicts in multimedia pollution control related to utility compliance with Title IV of the Clean Air Act Amendments of 1990

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for vapor samples obtained during the operation of mixer pumps in tank 241-AZ-101. The primary purpose of the mixer pump test (MPT) is to demonstrate that the two 300 horsepower mixer pumps installed in tank 241-AZ-101 can mobilize the settled sludge so that it can be retrieved for treatment and vitrification. Sampling will be performed in accordance with Tank 241-AZ-101 Mixer Pump Test Data Quality Objective (Banning 1999) and Data Quality Objectives for Regulatory Requirements for Hazardous and Radioactive Air Emissions Sampling and Analysis (Mulkey 1999). The sampling will verify if current air emission estimates used in the permit application are correct and provide information for future air permit applications.

2000-04-10

292

Structural aging program to assess the adequacy of critical concrete components in nuclear power plants

Most analyses of the alternative strategies used by utilities to comply with Title IV requirements have focused on factors directly related to controlling sulfur dioxide (SO{sub 2}) emissions. However, utilities must meet a number of additional environmental requirements at the same tune they comply with the acid rain program. To illuminate the potential synergies and conflicts that might exist between the other regulatory mandates and the acid rain program, a thorough examination of all the various programs and their interrelationships must be conducted. This paper reviews the environmental mandates that utilities will have to plan to meet in the next decade concurrently with the acid rain program, and it analyzes the interactions among the various programs to identify potential synergies and conflicts.

1993-11-01

293

Stream, lake, estuary, and ocean pollution, 2nd edition

The Structural Aging (SAG) Program is carried out by the Oak Ridge National Laboratory (ORNL) under sponsorship of the United States Nuclear Regulatory Commission (USNRC). The Program has evolved from preliminary studies conducted to evaluate the long-term environmental challenges to light-water reactor safety-related concrete civil structures. An important conclusion of these studies was that a damage methodology, which can provide a quantitative measure of a concrete structure's durability with respect to potential future requirements, needs to be developed. Under the SAG Program, this issue is being addressed through: establishment of a structural materials information center, evaluation of structural component assessment and repair technologies, and development of a quantitative methodology for structural aging determinations. Progress to date of each of these activities is presented as well as future plans. 7 refs., 5 figs.

1989-08-14

294

Status of the ANS low power and shutdown PRA standard

This book, an updated version of the 1985 edition, contains thirteen chapters, beginning with a preface which provides the objective of the book. The primary objective is to offer a comprehensive survey of the biological, hydrological, mathematical, and biochemical aspects of stream, lake, estuary, and ocean pollution analysis. The book also contains ten appendices of useful tables and nomographs of pertinent data. This book provides a very good summary and review of stream, lake, estuary, and ocean pollution. This book is recommended for environmental engineering students, environmental consulting engineers, and regulatory personnel. It provides an excellent summary of the field of stream and lake analysis and modeling. Every chapter includes a significant number of questions and pertinent references.

1991-01-01

295

Sell lumens, not kilowatts: The future for electric utilities

The Low Power and Shutdown (LPSD) PRA (Probabilistic Risk Assessment) Standard (ANS-58.22) is currently being drafted by a Writing Group under the auspices of the Risk Informed Standards Committee of the American Nuclear Society (ANS). The Writing Group includes representatives from nuclear utilities, US Nuclear Regulatory Commission (NRC), national laboratories, universities, and consultants with substantial experience producing LPSD PRAs. This draft standard is scheduled to be released for public comment in the second quarter of 2004, with publication by the end of 2004. The LPSD PRA Standard is based on a mature technology that shares many requirements with full power PRAs. It will provide specific methods and criteria whereby PRAs of appropriate quality and scope can be used in the conduct of plant decision-making and other activities, including addressing NRC requirements. This paper presents the current status of this standard.

2004-07-01

296

Seismic qualification method of equipment for nuclear power plant

The key to the future for electric utilities will not be found in legislation or regulation. Title VII of the Energy Policy Act of 1992 will prove to be just as ineffectual in improving the industry's position as was the Public Utility Regulatory Policies Act of 1978. These legislative palliatives, which produced so much commotion and so many reams of heated commentary, are largely irrelevant to a successful future for electric utilities. The key will be found in economics, not in law, and the future will lie in completing Thomas A. Edison's century-old vision for the industry, half of which the industry has heretofore ignored. The industry must embrace the complete vision and evolve from electric utilities into [open quotes]end-use energy utilities.[close quotes

1993-04-01

297

Safety evaluation report related to the operation of Grand Gulf Nuclear Station, Units 1 and 2. Dockets Nos. 50-416 and 50-417, Mississippi Power and Light Company; Middle South Energy, Inc. , South Mississippi Electric Power Association

Safety related equipment installed in Korean Nuclear Power Plants are required to perform a safety function during and after a seismic event. To accomplish this safety function, they must be seismically qualified in accordance with the intent and requirements of the USNRC Reg. Guide 1.100 Rev. 02 and IEEE Std. 344-1987. This paper defines and summarizes acceptable criteria and procedures, based on the Korean experience, for seismic qualification of purchased equipment to be installed in a nuclear power plant. As such the paper is intended to be a concise reference by equipment designers, architectural engineering company and plant owners in uniform implementation of commitments to nuclear regulatory agencies such as the USNRC or Korea Institute of Nuclear Safety (KINS) relating to adequacy of seismic Category 1 equipment. Thus, the paper provides the methodologies which can be used for qualifying equipment for safely related service in Nuclear Power Plants in a ...

1995-12-31

298

Safety considerations in the application of tension leg platforms and spar based systems

Supplement 2 to the Safety Evaluation Report for Mississippi Power and Light Company, et. al, joint application for licenses to operate the Grand Gulf Nuclear Station, Units 1 and 2, located on the east bank of the Mississippi River near Port Gibson, in Claiborne County, Mississippi, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report.

1982-06-01

299

SRS environmental technology development field test platform

This paper is focused on TLP and Spar technology as applied to floating production applications. In particular, safety considerations as related to classification and certification requirements are addressed. This covers hull structures, marine systems, production facilities and the relevant mooring systems for each platform type from design approval on through construction, installation and ultimately the ongoing maintenance of the platform to acceptable standards throughout its operating life. The experience of the American Bureau of Shipping with these platforms will be utilized in supporting the practical application of classification and regulatory standards to ensure safe operations and concluding that use of such standards in conjunction with an experienced classification society provides a substantial benefit to companies utilizing these technologies. (author)

1998-07-01

300

Risk analysis in oil spill response planning

A critical and difficult step in the development and implementation of new technologies for environmental monitoring and characterization is successfully transferring these technologies to industry and government users for routine assessment and compliance activities. The Environmental Sciences Section of the DOE Savannah River Technology Center provides a forum for developers, potential users, and regulatory organizations to evaluate new technologies in comparison with baseline technologies in a well characterized field test bed. The principal objective of this project is to conduct comprehensive, objective field tests of monitoring and characterization technologies that are not currently used in EPA standard methods and evaluate their performance during actual operating conditions against baseline methods. This paper provides an overview of the field test site and a description of some of the technologies demonstrated at the site including their field ...

1995-09-01

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301

Review on the immunology of European sea bass Dicentrarchus labrax

Tiered response is a basic approach to emergency plans, including oil spill response (OSR). This paper delineates a huge set of accidental scenarios within a certain tier of response generated by a computer during risk assessment. Parameters such as the amount of oil spilled, duration of discharge and types of losses should be provided in OSR scenarios. Examples of applications include offshore installations, sub sea or onshore pipelines, and localized onshore facilities. The paper demonstrates how to use risk analysis results for delineating all likely spills into groups that need a specific tier response. The best world practices and Russian regulatory approaches were outlined and compared. Corresponding algorithms were developed and their application in pipelines was presented. The algorithm combines expert's skills and spill trajectory modeling with the net environmental benefit analysis principle into the incident specific emergency response planning. ...

2005-07-01

302

British Library Electronic Table of Contents (United Kingdom)

European sea bass (Dicentrarchus labrax L.) is a marine species of great economic importance, particularly in Mediterranean aquaculture. However, numerous pathogenic viruses, bacteria, fungi and parasites affect the species, causing various infectious diseases and thereby leading to the most heavy losses in aquaculture production of sea bass. In this respect, knowledge on molecular and genetic mechanisms of resistance to pathogens and specific features of immune response against various infectious agents should greatly benefit the development of effective vaccines and proper vaccination strategies in marker-assisted selection of fish resistant to a range of infections. To date, genetic knowledge on sea bass immune regulatory genes responsible for resistance to pathogens is relatively poor ...

2007-01-01

303

Review of scenario earthquake developing methods based on the PSHA results

Review of Regulatory Quality Assurance Requirements for the Operation of Nuclear R and D Facilities

In this study, the two methods, US NRC and JAERI method, for the determination of scenario earthquakes for seismic design of nuclear power plants based on the probabilistic seismic hazard analysis were reviewed. The scenario earthquakes were developed for the Wolsung NPP site using the PSHA results based on the US NRC Regulatory Guide 1.165 procedures. It seems that the JAERI method is more appropriate to incorporate the effects of individual seismic sources and active faults, and to estimate the multiple ground motion parameters. The magnitude and distance bins of the scenario earthquakes for Wolsung NPP site were M6.4, 9km and M6.2, 13km.

2002-10-01

304

Report of the ASSET (Assessment of Safety Significant Events Team) mission to the Zaporozhe nuclear power plant in Ukraine 13-24 June 1994 Division of Nuclear Safety. Root cause analysis of operational events with a view to enhancing the prevention of incidents

Korea Atomic Energy Research Institute (KAERI) has many R and D facilities in operation, including HANARO research reactor, radioactive waste treatment facility (RWTF), post-irradiation examination facility (PIEF) and irradiated material test facility (IMEF). Recently, nation-wide interest is focused on the safety and security of major industrial facilities. Safe operation of nuclear facilities is imperative because of the consequence of public disaster by radiological release/ contamination, in case of an accident. Recently, Ministry of Science and Technology (MOST) of the Korean government announced amendments of Atomic Energy laws to enforce requirements of the physical protection and radiological emergency. In this paper, the context of amended Atomic Energy laws were reviewed to confirm quality assurance measures and identify additional QA activities, if any, that is required by the amendment

2005-10-27

305

Reliability analysis of stiff versus flexible piping. Status report

The IAEA Assessment of Safety Significant Events Team (ASSET) report presents the results of an ASSET team's assessment of their investigation of the effectiveness of the plant for prevention of incidents since 1990 at Zaporozhe nuclear power plant. The results, conclusions and suggestions presented herein reflect the views of the ASSET experts. They are provided for consideration by the responsible authorities in Ukraine. The ASSET team's views presented in this report are based on visits to the plant, on review of documentation made available by the operating organization and on discussions with utility personnel. The report is intended to enhance operational safety at Zaporozhe by proposing improvements to the policy for the prevention of incidents at the plant. The report includes, as a usual practice, the official response of the operating organization as well as of the regulatory body to the ASSET recommendations. Figs.

2003-11-01

306

Regulatory aspects about the licensing of the improved technical specifications for the CNLV

Conservative design procedures adopted for nuclear piping systems usually result in stiff piping designs that use excessive support devices such as rigid supports and snubbers. Use of these piping support devices has created safety concerns. This report describes the interim result for a piping research project conducted at Lawrence Livermore National Laboratory (LLNL) for the US Nuclear Regulatory Commission (NRC). The overall objective of this research project is to develop modified design requirements and criteria which will improve piping reliability and minimize the use of pipe supports, snubbers, and pipe whip restraints. The current study was conducted to establish the necessary groundwork for this work based on the piping reliability analysis.

1984-04-01

307

Regulation of naturally occurring radioactive materials in Australia

The Operation Technical Specifications is a document that is attached to the Operation License of a nuclear power station and its are applicable since the first load of fuel begins in the reactor core. This document is normative and with its application it is assured the safe operation of the nuclear power station. For the case of the Laguna Verde Nucleo electric Central this is documented in the Condition No. 5 of the License of Operation. Any modification to the ETOs is subject to the evaluation by part of the regulator organism. This work describes the regulator frame and the evaluation process of the Improved Technical Specifications on the part of the regulator organism. It is also indicated the implementation process of the improved ETOs and the main characteristics and benefits that are obtained of these processes to maintain the safety of the nuclear power stations. (Author)

2007-07-01

308

British Library Electronic Table of Contents (United Kingdom)

In order to promote uniformity between jurisdictions, the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) has developed the National Directory for Radiation Protection, which is a regulatory framework that all Australian governments have agreed to adopt. There is a large and diverse range of industries involved in mining or mineral processing, and the production of fossil fuels in Australia. Enhanced levels of naturally occurring radionuclides can be associated with mineral extraction and processing, other industries (e.g. metal recycling) and some products (e.g. plasterboard). ARPANSA, in conjunction with industry and State regulators, has undertaken a review and assessment of naturally occurring radioactive material (NORM) management in Australian industries. This rev...

2011-01-01

309

Regression of rat mammary tumors associated with suppressed growth hormone.

Recent strategy and progress in Korean nuclear PLIM program

Serum growth hormone (GH) was suppressed in female rats bearing mammary tumors induced by 7, 12, dimethylbenz(a)anthracene (DMBA) or N-nitrosomethylurea(NMU). Serum GH was suppressed due to treatment with a human GH analog produced by the plerocercoid stage of the tapeworm Spirometra mansonoides. Rats treated with plerocercoid growth factor (PGF) via plerocercoid infection had accelerated growth rates despite marked reductions in GH levels. Approximately two-thirds of the mammary tumors induced by either DMBA or NMU regressed during three weeks of exposure to PGF while most of the control tumors continued to grow. The data support an important regulatory role for GH in growth of mammary tumors in rats. PMID:3019224

310

Radioactive waste isolation in salt: peer review of Westinghouse Electric Corporation's report on reference conceptual designs for a repository waste package

The strategy for the Korean nuclear power plant lifetime management (PLIM) program, which has been developed over the last 3 years, is introduced, together with descriptions of recent events and related maintenance activities. This leading Korean PLIM project has been focused on such areas as a plant data survey, screening and prioritization of systems, structures and components (SSCs), aging evaluation of major components, economic analysis and regulatory issues. The current status is outlined in terms of major tasks including aging evaluation of 13 major components. The future long-term plan which eventually aims at maximizing the economic benefit for both the utility and its customers is presented. Also described is the technical development required for plant life extension. (orig.).

1996-05-08

311

Radiation protection and the role of TSOs in Kenya

This report documents the findings of the peer panel constituted by Argonne National Laboratory to review Region A of Westinghouse Electric Corporation's report entitled Waste Package Reference Conceptual Designs for a Repository in Salt. The panel determined that the reviewed report does not provide reasonable assurance that US Nuclear Regulatory Commission (NRC) requirements for waste packages will be met by the proposed design. It also found that it is premature to call the design a ''reference design,'' or even a ''reference conceptual design.'' This review report provides guidance for the preparation of a more acceptable design document.

1985-10-01

312

RISKAUDIT Report no. 7, Vol. 1: Safety evaluation of VVER 440/213 and VVER 1000/320 reactors in Rovno NPP Units 1, 2 and 3. Final Report by AIB-Vincotte Nuclear, CIEMAT, ANPA, GRS, IPSN, AEA-T

Since the late '60s and through the early '90s Kenya has always recognized and appreciated the need for support from Technical and Scientific Support Organizations (TSOs) for activities geared towards enhancing nuclear and radiation safety. The TSOs have since then gained increasing importance for provision of technical and scientific basis for policy formulation, implementation and legislation with regard to radiation safety. National and specific operator programmes on safety and security of radiation source and radioactive waste recognize and encourage the active participation of TSOs. Due to the role they play, technical competence, transparency and the observance of ethical practices have become essential both for the regulator and the regulated. In this respect, interaction and cooperation between stake holders (regulatory authorities, users of radiation, generators of radioactive waste, professional organizations) and TSOs, in the frame of national and ...

2007-08-01

313

RESRAD model presentation

The Riskaudit 7 report has been made by a group of independent experts from Western European countries representing technical organizations specialized in the support of regulatory bodies of those countries. It represents a preliminary estimation of the Ukrainian WWER B 213 and B 320 reactors, based on the example of Rovno NPP, analysed with a Western practice. The first part of the document covers the following aspects of the report: core design and fuel management; pressurized components; electrical supply; instrumentation and control; containment; internal events; site conditions and external events.

1994-07-15

314

Quality differentiated tariffs; Kvalitetdifferensierte tariffer

RESRAD was one of the multimedia models selected by the US Nuclear Regulatory Commission (NRC) to include in its workshop on radiation dose modeling and demonstration of compliance with the radiological criteria for license termination. This paper is a summary of the presentation made at the workshop and focuses on the 10 questions the NRC distributed to all participants prior to the workshop. The code selection criteria, which were solicited by the NRC, for demonstrating compliance with the license termination rule are also included. Among the RESRAD family of codes, RESRAD and RESRAD-BUILD are designed for evaluating radiological contamination in soils and in buildings. Many documents have been published to support the use of these codes. This paper focuses on these two codes. The pathways considered, the databases and parameters used, quality control and quality assurance, benchmarking, verification and validation of these codes, and capabilities as well as ...

1998-05-01

315

Probiotic-Induced Priming of Innate Immunity to Protect Against Rotaviral Infection

Flexible delivery reliability (FLP), which is in focus in this report, means that the customer shall be able to choose from a number of different grid tariffs of different qualities. This way he shows his actual willingness to pay for quality. It is an important difference compared with the KILE system, which is based on a surveyed willingness to pay. As it is planned to be implemented, FLP assumes that the customer must choose one of a number of different subscriptions and that he makes his choice based on his own preferences and costs what suits him best. The various subscribers entail different degrees of delivery reliability. For the grid companies, customers and regulatory authorities the FLP represents a challenge. It is assumed that the customers have a conscious attitude or preference with respect to delivery quality. That is not always the case today.

2003-11-01

316

British Library Electronic Table of Contents (United Kingdom)

Understanding of probiotic-induced regulatory gene expression and networking is critical to further explore their roles in controlling infection. Transcriptional profile of selected innate immune genes in primary bovine intestinal epithelial cells was assessed over a time course of incubation with the probiotic Lactobacillus plantarum 299v. Based on gene expression results, a time point was chosen to prime epithelial cells with the probiotic prior to infection with rotavirus. Plaque assays and genomic analysis provided the basis for establishing the efficacy of probiotics in preventing a rotaviral infection. Plaque assays revealed that the probiotic is capable of decreasing (at least by 100-fold) the levels of live virus when the cells were primed with the probiotic. Results from gene expr...

2010-01-01

317

Preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals: strategy, challenges, current practices

British Library Electronic Table of Contents (United Kingdom)

Abstract Evaluation of pharmaceutical agents in children is now conducted earlier in the drug development process. An important consideration for this pediatric use is how to assess and support its safety. This article is a collaborative effort of industry toxicologists to review strategies, challenges, and current practice regarding preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals. Biopharmaceuticals include a diverse group of molecular, cell-based or gene therapeutics derived from biological sources or complex biotechnological processes. The principles of preclinical support of pediatric drug development for biopharmaceuticals are similar to those for small molecule pharmaceuticals and in general follow the same regulatory guidances outlined by...

2011-01-01

318

Plant maintenance and plant life extension issue, 2006

Packing for food irradiation

The focus of the March-April issue is on plant maintenance and plant life extension. Major articles/reports in this issue include: Spent fuel: myths and facts, by Jeffrey S. Merrifield, U.S. Nuclear Regulatory Commission; Critical pipe replacement procedure, by Geoff Gilmore, Climax Portable Machine Tools Inc.; Improving maintenance performance, by Larry Meyer and Joe Giuffre, DC Cook Nuclear Plant, American Electric Power; Equipment deficiency intolerance index, by Douglas F. Helms, Tennessee Valley Authority; Plant profile: I and C modernization at Dukovany, by Josef Rosol, CEZ Dukovany NPP, Czech Republic; and, Report: new plant activities.

2006-03-15

319

Overview of nuclear power plant equipment qualification issues and practices

Joint FAO/IAEA/WHO Expert Committee approved the use of radiation treatment of foods. Nowadays food packaging are mostly made of plastics, natural or synthetic, therefore effect of irradiation on these materials is crucial for packing engineering for food irradiation technology. By selecting the right polymer materials for food packaging it can be ensured that the critical elements of material and product performance are not compromised. When packaging materials are in contact with food at the time of irradiation that regulatory approvals sometimes apply. The review of the R-and-D and technical papers regarding material selection, testing and approval is presented in the report. The most information come from the USA where this subject is well elaborated, the International Atomic Energy Agency (IAEA) reports are reviewed as well. The report can be useful for scientists and food irradiation plants operators. (author)

320

OSHA Hazardous-Chemical Occupational Exposure Standard for laboratories: A new management regulation to ensure employee health. Final report

This report presents a view of and commentary on the current status of equipment qualification (EQ) in nuclear industries of the major western nations. The introductory chapters discuss the concepts of EQ, the elements of EQ process and highlight some of the key issues in EQ. A brief review of industry practices and some of the prevalent industrial standards is presented, followed by an overview of current regulatory positions in the USA, France, Germany and Sweden. A summary and commentary on the latest research findings on issues relating to accident simulation, to aging simulation and some special topics related to EQ, has been contributed by Franklin Research Centre of Philadelphia. The last part of the report deals with equipment qualification in Canada and gives recommendations on EQ for new plants as well as currently operational CANDU nuclear power plants.

1984-05-15

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

New models needed to manage gas supply, APPrO conference hears

The OSHA's chemical occupational exposure standard for laboratories is an outgrowth of the previously issued Hazard Communication Standard. The standard relieves laboratories from complying with general industry standards but does not require compliance with specific guidelines. The heart of the standard is the creation of a Chemical Hygiene Plan (CHP) in every laboratory. The CHP addresses major issues such as safety equipment and procedures, work practices and training, the designation of a chemical hygiene officer, and the provision of medical consultation and examination for affected employees. This new standard, in effect as of 31 January, 1991, presents yet another regulatory challenge to laboratory managers but also will ensure a safer work environment for laboratory workers.

1991-04-01

322

Morphologie des cellules de levure et la reproduction sexuelle - Apercu general et quelques considerations

Details of a 1 day conference designed to create more efficient interactions between the gas supply and electricity systems in Ontario and new models for gas supply and the electricity system were presented. Market efficiency, generators' perspectives on critical gas issues, an overview of the North American gas and an outline of issues concerning Ontario were discussed. A natural gas industry forecast and issues concerning marketers and producers were presented. The terms on which gas is bought and sold were discussed. Regulatory tools, cost allocation and issues relating to unbundling were also presented. Infrastructure needs were reviewed, as well as basic market structures. It was suggested that appropriate commercial service options need to be developed and approved, including cross-utility services.

2005-08-01

323

British Library Electronic Table of Contents (United Kingdom)

Over the decades, basic research in life sciences has profited greatly from the study of the small unicellular fungal species Saccharomyces cerevisiae. This yeast turned out to be key for the identification and understanding of molecular mechanisms that underlay the basic functions of all eukaryotic cells. These include, but are not limited to, the regulatory mechanisms behind cellular reproduction (cell cycle control), cellular morphogenesis (cell polarity, cytoskeleton and membrane trafficking) and the management of cellular information (chromosome biology, transcription and translation). Rapid access to genomic information of many yeast species, combined with bioinformatics analyses, provide information on the evolutionary history of yeasts and the molecular ancestry of their constituen...

2011-01-01

324

Integrity of feedwater and main steam piping in KWU light water reactor plants

Insights into the ASME PRA Standard-based Quality Evaluation on the Existing KSNP LERF Model

New standard catalogs for piping, supports, and valves have been introduced by Kraftwerk Union (KWU) for the first time in its Convoy series of PWR plants. These catalogs, underlying regulatory codes, and newly developed KWU specifications are described. Feedwater and main steam piping systems within the containment, including pipe supports and valves, are used to demonstrate the high quality level of piping technology achieved in the Federal Republic of Germany. Such quality standards ensure the integrity of single components as well as of the entire system, so that, under certain conditions, pipe whip restraints against postulated breaks have become unnecessary. The quality aspects apply basically for both PWR and BWR plants of KWU.

1986-07-01

325

Insights into the ASME PRA Standard-based Quality Evaluation on the Existing KSNP LERF Model

The current Risk-informed Regulation (RIR) framework employs both a Level 1 Core Damage Frequency (CDF) and a Level 2 Large Early Release Frequency (LERF) as two surrogate measures for the plant risk. For their use in making regulatory decisions for the plant risk, it has been required to maintain an appropriate level of quality for the plant risk models. The first step for this purpose is to evaluate the quality of the PSA model in a qualitative or quantitative manner. Recently, a similar type of quality evaluation has been made for the KSNP Level 1 PSA model based on an ASME PRA Standard for the RIR application, but not for the corresponding LERF model. The main objective of this paper is to provide the ASME PRA Standard-based evaluation result for the existing KSNP Level 2 LERF model and the insights obtained from the evaluation process.

2005-07-01

326

Indexes to Nuclear Regulatory Commission issuances, July--December 1996. Volume 44, Index 2

The current Risk-informed Regulation (RIR) framework employs both a Level 1 Core Damage Frequency (CDF) and a Level 2 Large Early Release Frequency (LERF) as two surrogate measures for the plant risk. For their use in making regulatory decisions for the plant risk, it has been required to maintain an appropriate level of quality for the plant risk models. The first step for this purpose is to evaluate the quality of the PSA model in a qualitative or quantitative manner. Recently, a similar type of quality evaluation has been made for the KSNP Level 1 PSA model based on an ASME PRA Standard for the RIR application, but not for the corresponding LERF model. The main objective of this paper is to provide the ASME PRA Standard-based evaluation result for the existing KSNP Level 2 LERF model and the insights obtained from the evaluation process

2005-10-27

327

Impact of ocean pollution

Digests and indexes for issuances of the Commission (CLI), the Atomic Safety and Licensing Board Panel (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Decision on Petitions for Rulemaking (DPRM) are presented in this document. These digests and indexes are intended to serve as a guide to the issuances. Information elements common to the cases heard and ruled upon are: case name (owner(s) of facility); full text reference (volume and pagination); issuance number; issues raised by apellants; legal citations (cases, regulations, and statutes); name of facility, docket number; subject matter of issues and/or rulings; type of hearing (operating license, operating license amendment, etc.); type of issuance (memorandum, order, decision, etc.).

1997-04-01

328

IEEE [Institute of Electrical and Electronics Engineers] standards and nuclear software quality engineering

Man's wastes are polluting the oceans from various sources and delivered by various routes. The result has been the loss of habitat and the irreversible altering of marine ecosystems. Development in the coastal zones and offshore activities that disrupt biologically sensitive areas have led to international negotiations to regulate these impacts and develop a law of the sea. Basic to international cooperation, however, is the need to develop answers to questions about the ecological consequences of development programs and the carrying capacity of the oceans. Current information does not demonstrate long-term global impacts, making it difficult to detect and predict incremental changes and causal relationships. Society needs to determine how much environmental damage it will accept and then to develop appropriate technology, such as biomonitoring. Society also needs to reexamine its positions on technology-based regulatory controls to see if the effects of ...

1981-03-01

329

Helium/solid powder O-ring leakage correlation experiments using a radiotracer

Significant new nuclear-specific software standards have recently been adopted under the sponsorship of the American Nuclear Society and the American Society of Mechanical Engineers. The interest of the US Nuclear Regulatory Commission has also been expressed through their issuance of NUREG/CR-4640. These efforts all indicate a growing awareness of the need for thorough, referenceable expressions of the way to build in and evaluate quality in nuclear software. A broader professional perspective can be seen in the growing number of software engineering standards sponsored by the Institute of Electrical and Electronics Engineers (IEEE) Computer Society. This family of standards represents a systematic effort to capture professional consensus on quality practices throughout the software development life cycle. The only omission-the implementation phase-is treated by accepted American National Standards Institute or de facto standards for programming languages.

1988-06-12

330

Hazardous-waste disposal and the clinical laboratory. Final report, May-December 1989

UO/sub 2/ definitely leaked past the O-ring in three of the tests confirming the major results of the previous work. Continuous leakage at these levels may require additional precautions under present regulatory policies. The mechanism and the time and particle size dependence for the leakage are not known, but there is some indication leakage is more likely at low temperatures. It is possible leakage is due to movement of the O-ring during temperature or pressure cycling at the beginning or end of a test. The radiotracer method involves less labor and is much less susceptible to contamination than the previous method. Future work will investigate leakage past lubricated O-rings and time dependence of leakage. 1 reference, 1 table.

1984-01-01

331

Exclusion, exemption and clearance in the mining and minerals industry - A review of the concepts from a South African perspective

Negligent hazardous waste management has resulted in real threats to public health. The Federal Government has responded to the situation with laws and regulations aimed at the producers of hazardous waste, including clinical laboratories. The Resources Conservation and Recovery Act (RCRA) imposes controls on hazardous waste management through the Code of Federal Regulations (CFR). The Environmental Protection Agency (EPA) and the Department of Transportation (DOT) regulate these activities through 40 CFR and 49 CFR. Most clinical laboratories can operate satellite accumulation points and accumulate, store, transport, and dispose of waste in accordance with EPA and DOT regulations. Regulations pertaining to infectious waste, sure to affect many clinical laboratories, are being developed now by he EPA. The cradle to grave tracking system mandated by the Federal Government can be supplemented by state and local authorities and poses a significant regulatory challenge ...

1990-01-01

332

Estimating pressurized water reactor decommissioning costs: A user`s manual for the PWR Cost Estimating Computer Program (CECP) software. Draft report for comment

The risks from mining and processing of ores is reviewed on a generic basis with particular reference to some of the confusions which can arise due to lack of consistency or common logic in the use of exclusion, exemption and clearance. The difference in exclusion and exemption are challenged by comparing doses received in high background radiation areas and the doses received from a mining practice. The common principle of risk to the human species is not applied consistently. The differences between IAEA recommendations and local regulatory conditions are compared, and the use of exemption levels as clearance levels is considered. A case study on management of mine tailings is presented with special focus on the use of clearance levels. In all areas of review the interpretation of regulation is subject to confusion resulting from inconsistencies which can distort free market economics. (author).

1997-05-06

333

Environmental information document: Savannah River Laboratory Seepage Basins

With the issuance of the Decommissioning Rule (July 27, 1988), nuclear power plant licensees are required to submit to the US Regulatory Commission (NRC) for review, decommissioning plans and cost estimates. This user`s manual and the accompanying Cost Estimating Computer Program (CECP) software provide a cost-calculating methodology to the NRC staff that will assist them in assessing the adequacy of the licensee submittals. The CECP, designed to be used on a personnel computer, provides estimates for the cost of decommissioning PWR plant stations to the point of license termination. Such cost estimates include component, piping, and equipment removal costs; packaging costs; decontamination costs; transportation costs; burial costs; and manpower costs. In addition to costs, the CECP also calculates burial volumes, person-hours, crew-hours, and exposure person-hours associated with decommissioning.

1993-10-01

334

Effective regulation for sustainable public transport in developing countries

This document provides environmental information on postulated closure options for the Savannah River Laboratory Seepage Basins at the Savannah River Plant and was developed as background technical documentation for the Department of Energy`s proposed Environmental Impact Statement (EIS) on waste management activities for groundwater protection at the plant. The results of groundwater and atmospheric pathway analyses, accident analysis, and other environmental assessments discussed in this document are based upon a conservative analysis of all foreseeable scenarios as defined by the National Environmental Policy Act (CFR, 1986). The scenarios do not necessarily represent actual environmental conditions. This document is not meant to be used as a closure plan or other regulatory document to comply with required federal or state environmental regulations.

1987-03-01

335

British Library Electronic Table of Contents (United Kingdom)

This paper has two key objectives. Firstly, using the findings from case study research undertaken in Colombo (Sri Lanka), Faisalabad (Pakistan) and Dar es Salaam (Tanzania), the paper seeks to demonstrate the importance of an appropriate regulatory framework and effective mechanisms of enforcement for sustainable urban transport systems in developing countries. Secondly, the paper highlights the critical importance of communication and co-ordination between stakeholders (defined here as transport users, providers and regulators) if regulation is to be effective. The views of poor and disadvantaged passenger groups-women, children, the elderly and disabled-are used in the paper to illustrate the importance of transport systems to their livelihoods, such as work, education, health and socia...

2006-01-01

336

Economic impact analysis for proposed effluent limitations guidelines and standards for the coastal subcategory of the oil and gas extraction point source category

Development of in-vessel reflood instrumentation at ORNL

This economic impact analysis (EIA) examines compliance costs and economic impacts resulting from the U.S. Environmental Protection Agency`s (EPA`s) proposed revisions to effluent limitations guidelines and standards for the Coastal Subcategory of the U.S. oil and gas industry. The EIA estimates economic impacts in terms of annualized costs; production losses; and changes in equity, working capital, and other indicators of financial health at the firm level. In addition, impacts on employment and affected communities, foreign trade, and new sources are considered. A Regulatory Flexibility Analysis detailing the impacts on small businesses within the coastal oil and gas industry also is included in the EIA.

1995-01-01

337

Development of Reliability Data Management System (RDMS) for safety systems of PHWR type plants

A program under the sponsorship of the United States Nuclear Regulatory Commission was intiated at the Oak Ridge National Laboratory (ORNL) in late 1977. The program, Advanced Instrumentation for Reflood Studies (AIRS), is charged with developing instrumentation for measurement of in-vessel fluid phenomena in pressurized water reactor reflood facilities. The goal of the ORNL program is to develop techniques and systems for measuring fluid flow in-core, deentrainment in the upper plenum and liquid fallback from the upper plenum into the core. A large portion of the development at ORNL is devoted to the impedance probes for measurement of two-phase flow velocities and void fractions. Film probe development at ORNL is limited to adapting the present techniques to the environment of a reflood facility. As the development progresses on all the measurement techniques, ORNL will fabricate and supply instrument systems to the reflood facilities included in the 2D/3D ...

2004-09-06

338

Development document for proposed effluent limitations guidelines and standards for the centralized waste treatment industry. Volumes 1 and 2

The Reliability Data Management System (RDMS) for safety systems of PHWR type plants has been developed and utilized in the reliability analysis of the special safety systems of Wolsong Unit 1 with plant overhaul period lengthened. The RDMS is developed for the periodic efficient reliability analysis of the safety systems of Wolsong Unit 1. In addition, this system provides the function of analyzing the effects on safety system unavailability if the test period of a test procedure changes as well as the function of optimizing the test periods of safety-related test procedures. The RDMS can be utilized in handling the requests of the regulatory institute actively with regard to the reliability validation of safety systems.

1999-10-01

339

Developing a standardized test procedure for hybrid vehicles: The challenge of the SAE HEV task force

This document includes the following topics: Background; Data Collection; Scope/Applicability of the Proposed Regulation; Description of the Industry; Industry Subcategorization; Pollutants of Concern for the Centralized Waste Treatment Industry; Pollutants Selected for Regulation; Wastewater Treatment Technologies; Regulatory Options Considered and Selected for Basis of Regulation; Long-Term Averages, Variability Factors, and Limitations and Standards; Cost of Treatment Technologies; Pollutant Loading and Removal Estimates; Non-Water Quality Impacts; Implementation; Analytical Methods and Baseline Values; List of Definitions; List of Acronyms; Appendix A--Pollutant Groups; Appendix B--Listing of Characerization Data From Non-Hazardous Oils Facilities; Appendix C--Listing of Daily Influent and Effluent Measuements; Appendix D--Facility-Specific Compliance Costs; Appendix E--Attachements to Chapter 10; and Appendix F--Listing of Pollutants of Concern and Cas ...

1998-12-01

340

Creating reliable pharmaceutical distribution networks and supply chains in African countries: Implications for access to medicines

In 1992, the Society of Automotive Engineers (SAE) established a task force to develop a procedure for measuring electric energy consumption, all-electric range, fuel economy, and exhaust emissions for hybrid vehicles; the procedure will be submitted to regulatory agencies as representing the automotive industry`s recommendations. The draft procedure is currently being tested on hybrid vehicles. The University of Maryland`s parallel hybrid was tested in September 1994, and the University of California-Davis` parallel hybrid and the University of Illinois` series hybrid will be tested in November 1994 and January 1995, respectively. The procedure is being modified to incorporate any lessons learned, and the task force hopes to recommend the final procedure to the SAE by mid 1995.

1994-11-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

British Library Electronic Table of Contents (United Kingdom)

The presence of inefficient distribution networks and supply chains of medicines creates problems in that even if African countries can secure steep, sustainable cost-containing procurements, access to needed medicines may still be impaired. The expected health benefits from affordable pricing or subsidies on prices of medicines may not be realized. This article evaluates drug supply chains in African countries and advocates for consolidated private wholesale markets and multiplicity of retail pharmacies. Public supply chains should be shortened and supported by contracting out with private distributors, including wholesalers and retail pharmacies. Additionally, drug regulatory authorities should be allowed to charge registration fees that are proportionate to the costs of technical regula...

2009-01-01

342

Cost effectiveness analysis of proposed effluent limitations guidelines for the pulp, paper, and paperboard industry

Consuming for production - Procurement for power production at Cernavoda NPP - Nuclear Sector

The cost-effectiveness (CE) analysis presents an evaluation of the technical efficiency of pollutant control options for the proposed effluent limitations guidelines. The proposed BAT and PSES apply to six subcategories: Dissolving Kraft; Dissolving Sulfite; Bleached Papergrade Kraft; Papergrade Sulfite; Unbleached Kraft; and Semichemical. The document compares the total annualized cost incurred for each of the regulatory options within each subcategory to the corresponding effectiveness of that option in reducing the discharge of pollutants. Section Two discusses the cost-effectiveness methodology and identifies the pollutants included in the analysis and their toxic weighting factors. Section Three describes the options evaluated for each subcategory. Section Four presents the results of the CE analysis. Section Five presents a separate analysis of AOX (adsorbable organic halides).

1993-11-01

343

Comparisons of the SCDAP computer code with bundle data under severe accident conditions

The paper presents some aspects relating to the importance of a good communication and cooperation between all factors involved in procurement process at Societatea Nationala 'Nuclearelectrica', SNN. In order to comply with the internal and international rules related to safety in nuclear field and public procurement requirements and for maintaining a high standard of operational performance of Cernavoda NPP, adequate procurement systems were developed by SNN SA. The importance of human factor and the training activities for all personnel from this chain of procurement process is the main key issue to maintain high quality of their activities considering that procurement documents are reviewed and approved before to be issued by all departments involved in procurement process. The specialized department for public acquisition is supervising that the procurement processes initiated at the level of branches, in accordance with their needs and with respect to the requirements of the ...

2009-10-12

344

Common-Cause Failure Analysis for Reactor Protection System Reliability Studies

The SCDAP computer code, which is being developed under the sponsorship of the United States Nuclear Regulatory Commission, models the progression of light water reactor core damage including core heatup, core disruption and debris formation, debris heatup, and debris melting. SCDAP is being used to help identify and understand the phenomena that control core behavior during a severe accident, to help quantify uncertainties in risk assessment analysis, and to support planning and interpretation of severe fuel damage experiments and data. Comparisons between SCDAP calculations and the experimental data showed good agreement. Calculated and measured bundle temperatures for SFD-ST were within 200 K for the entire bundle and within 20 K for maximum cladding temperatures. For ESSI-2, calculated and measured maximum cladding temperatures were within 50 K, and the extensive liquefaction and relocation that was calculated was in agreement with experimental results.

1983-08-22

345

Cleantech: an opportunity in the crisis. Financing clean technologies; Cleantech: Chance in der Krise. Finanzierungsoptionen fuer Umwelttechnologien und neue Energien

Analyses were performed of the safety-related performance of the reactor protection system (RPS) at U.S. Westinghouse and General Electric commercial reactors during the period 1984 through 1995. RPS operational data from these reactors were collected from the Nuclear Plant Reliability Data System (NPRDS) and Licensee Event Reports (LER). The common-cause failure (CCF) modeling in the fault trees developed for these studies and the analysis and use of common-cause failure data were sophisticated, state-of-the-art efforts. The overall CCF effort helped to test and expand the limits of the U.S. Nuclear Regulatory Commission's CCF methodology.

1999-08-01

346

Class 1E digital systems studies

Despite the current global economic crisis, the Cleantech industry has excellent growth prospects. Especially technologies for water treatment, energy efficiency in buildings and combined heat and power will face high demand and high growth rates in the coming years, just like the suppliers for the wind and solar industry. Today German companies are market leaders in these segments. However, there is a threat that they will lose this competitive position as international competition increases. Besides attractive incentive schemes and regulatory framework, access to venture capital and the fast expansion to international markets is an important factor to secure the leading market position of German Cleantech companies. (orig.)

2009-07-01

347

Cholera toxin can catalyze ADP-ribosylation of cytoskeletal proteins

This document is furnished as part of the effort to develop NRC Class 1E Digital Computer Systems Guidelines which is Task 8 of USAF Rome Laboratories Contract F30602-89-D-0100. The report addresses four major topics, namely, computer programming languages, software design and development, software testing and fault tolerance and fault avoidance. The topics are intended as stepping stones leading to a Draft Regulatory Guide document. As part of this task a small scale survey of software fault avoidance and fault tolerance practices was conducted among vendors of nuclear safety related systems and among agencies that develop software for other applications demanding very high reliability. The findings of the present report are in part based on the survey and in part on review of software literature relating to nuclear and other critical installations, as well as on the authors' experience in these areas.

348

Brookhaven National Laboratory Coastal Meteorology Program, 1972-1983

Cholera toxin catalyzes transfer of radiolabel from ["3"2P]NAD"+ to several peptides in particulate preparations of human foreskin fibroblasts. Resolution of these peptides by two-dimensional gel electrophoresis allowed identification of two peptides of M/sub r/ = 42,000 and 52,000 as peptide subunits of a regulatory component of adenylate cyclase. The radiolabeling of another group of peptides (M/sub r/ = 50,000 to 65,000) suggested that cholera toxin could catalyze ADP-ribosylation of cytoskeletal proteins. This suggestion was confirmed by showing that incubation with cholera toxin and ["3"2P]NAD"+ caused radiolabeling of purified microtubule and intermediate filament proteins.

1981-01-01

349

Bioethics and the Stem Cell Research Debate

Research conducted at Brookhaven National Laboratory under the Coastal Meteorology and Diffusion Research Program from 1972 to 1983 is summarized by the following study areas: Diffusion Studies, Boundary Layer Studies, Coastal Meteorology Studies, Air-Sea Interaction Studies, Coastal Transport and Diffusion Climatology, Seabreeze Modeling and Instrument Development, all supported by the US Department of Energy. Studies supported by the Nuclear Regulatory Commission, the National Science Foundation and the American Petroleum Institute are also described. A summary of a Workshop on Coastal Atmospheric Transport Processes, an account of studies in progress, recommendations for future research and a description of facilities and instrumentation available are also included. A list of all publications and presentations prepared as part of the program is given with abstracts. 7 figures, 1 table.

1983-06-01

350

Benefits and applications of modular hydroelectric pumped storage

Bioethics--the study of ethical issues in science and medicine--has grown to become a significant academic and service-oriented discipline with its own research centers, conferences, journals, and degree programs. As these issues have moved to the center of public debate, the law has assumed an increasingly important place in the discipline of bioethics. Today, embryonic stem cell research stands out as a critically important issue about which the U.S. has neither ethical consensus nor clear, comprehensive regulation. The ethical debate centers on the fact that stem cell research involves the destruction of very early human embryos. This article provides a brief scientific background followed by a discussion of key ethical and legal/regulatory issues that surround embryonic stem cell research.

2005-12-01

351

An institutional architecture for meta-risk regulation in Irish banking: Lessons from Anglo Irish Bank’s Minsky moment

This paper reports on hydroelectric pumped storage which is the only proven and most efficient technology available for energy storage. It is used by utilities to provide peak and intermediate power and to optimize overall system performance. Because of increased environmental and regulatory constraints, few acceptable sites, long schedules, and huge financial commitments, large conventional pumped storage plants, are now virtually impossible to build. As an alternative, small modular pumped storage, with project sizes ranging from 25 MW to 200 MW, was created to overcome the difficulties of conventional projects. The modular approach involves standardizing the elements of a pumped storage plant by utilizing specialized siting techniques and optimizing design, equipment, and construction. Compared with conventional pumped storage, the modular design can reduce cost and expedite schedule; reduce environmental concerns and permitting obstacles; and expand ...

1991-07-24

352

British Library Electronic Table of Contents (United Kingdom)

The article maps the risk management failures within Anglo Irish Bank, showing that, when banks are systemic in nature, poor internal corporate governance within a Minsky credit cycle can lead to destabilising macroeconomic conditions, which may prolong the effects of a credit-induced downturn. The article highlights a failure of management at Anglo Irish Bank to establish and measure firm-level risks and develop appropriate internal controls to support a culture of prudent credit management. We propose the adoption of a novel supervisory architecture based on the meta-risk regulatory philosophy, which is designed to strengthen risk management practices at banks.

2011-01-01

353

An evaluation of the UK skills base for toxicologists and ecotoxicologists, with focus on current and future requirements, particularly with regard to the skills required for hazard assessment of chemical substances including nanomaterials

Environmental Research Database

Objectives1. To establish the present capacity and capability across all the sectors within the UK for - a) Undertaking research in the areas of toxicology and ecotoxicology and environmental hazard and risk assessment work on chemical subtances including emerging containments (e.g. enginerred nanomaterials); and b) Applying these skills in the policy and regulatory context. 2) The range of chemicals involved should include pharmaceutical and medical products, crop protection agents, biocides, vet [continued...]DescriptionThe aim of this project is to identify the current status of the scientific community, areas of expertise, and identify the gaps in skills, knowledge or recruitment. The project will use a questionnaire approach to obtain this information for all sectors of the business community. The analysis will identify the gaps in provision, and areas where investment is needed in future training and/or recruitment.

2009-01-15

354

Accumulation, Activity and Localization of Cell Cycle Regulatory Proteins and the Chloroplast Division Protein FtsZ in the Alga Scenedesmus quadricauda under Inhibition of Nuclear DNA Replication

British Library Electronic Table of Contents (United Kingdom)

Synchronized cultures of the green alga Scenedesmus quadricauda were grown in the absence (untreated cultures) or in the presence (FdUrd-treated cultures) of 5-fluorodeoxyuridine, the specific inhibitor of nuclear DNA replication. The attainment of commitment points, at which the cells become committed to nuclear DNA replication, mitosis and cellular division, and the course of committed processes themselves were determined for cell cycle characterization. FdUrd-treated cultures showed nearly unaffected growth and attainment of the commitment points, while DNA replication(s), nuclear division(s) and protoplast fission(s) were blocked. Interestingly, the FdUrd-treated cells possessed a very high mitotic histone H1 kinase activity in the absence of any nuclear division(s). Compared with the ...

2008-01-01

355

A study on the experimental verification for the pipe whip problem in a Nuclear Power Plant

A review of conservatism for the Canadian exclusion area boundary calculation methodology

The purpose of this study is to investigate on the experimental verification analysis for the pipe whip problems and to obtain the quantitative evaluation technologies for the design technique of pipe whip restraints. These will contribute to the advance of nuclear regulatory technologies and enhance nuclear power plant safety. This study presents the experimental and transient analytical results of pipe whip tests using the 4', 6' diameter pipe and U-shaped restraints. In the tests, the effects of the overhang length, clearance, impact height on the pipe whip behavior of the pipe-restraints were investigated. The transient impact analysis of the pipe-restraint system was conducted by the finite element program ABAQUS. The applicability of the ABAQUS program to the pipe whip analysis is made clear through this analysis.

1993-12-15

356

A radiation monitoring system for nuclear fusion devices

At present, two types of reactors, Pressurized Light Water Reactor(PLWR) and Pressurized Heavy Water Reactor(PHWR), are operating and under construction in Korea. They are much different in design concepts and inherent features from each other so that the calculation methods for Exclusion Area Boundary(EAB) are also different from each other. Thus, the domestic calculation methodology has been applied to PHWR, Wolsung 2, 3 and 4. In this report, the regulatory requirements and methodologies for EAB of Canadian methodology for EAB has been also investigated. It has been examined that the Canadian methodology which has been applied to the calculation of EAB of Wolsung 2, 3 and 4 can be said to be conservative enough compared to physical phenomena. 4 tabs., 3 figs., 22 refs. (Author).

1996-06-01

357

A compilation of reports of the Advisory Committee on Reactor Safeguards: 1992 Annual. Volume 14

Fusion device produces high-level neutrons and #gamma#-rays, which would hazard the safety of the public and workers if the doses would be higher than the regulatory limits because of leakage from the bio-shielding and skyshine. It is essential to monitor the radiation doses in the workshop and the enumerative around fusion devices. A radiation monitoring system (RMS) for full (near and far) areas around a nuclear fusion device has been designed and developed, which can achieve the monitoring and controlling of radiation doses in the workshop area by using the Controller Area Network (CAN), in the institution area by using the Bluetooth Ad hoc network based on a new tree topology formation and routing protocol and in a long range environment by using the General Packet Radio Service (GPRS) network. (authors)

2005-12-01

358

A compilation of reports of the Advisory Committee on Reactor Safeguards: 1992 Annual

This compilation contains 50 ACRS reports submitted to the Commission, Executive Director for Operations, or to the Office of Nuclear Regulatory Research, during calendar year 1992. It also includes a report to the Congress on the NRC Safety Research Program. All reports have been made available to the public through the NRC Public Document Room and the US Library of Congress. The reports are divided into two groups: Part 1: ACRS Reports on Project Reviews, and Part 2: ACRS Reports on Generic Subjects. Part I contains ACRS reports alphabetized by project name and by chronological order within project name. Part 2 categorizes the reports by the most appropriate generic subject area and by chronological order within subject area.

1993-04-01

359

A compilation of reports of the Advisory Committee on Reactor Safeguards: 1991 annual. Volume 13

This compilation contains 50 ACRS reports submitted to the Commission, Executive Director for Operations, or to the Office of Nuclear Regulatory Research, during calendar year 1992. It also includes a report to the Congress on the NRC Safety Research Program. All reports have been made available to the public through the NRC Public Document Room and the US Library of Congress. The reports are divided into two groups: Part 1: ACRS Reports on Project Reviews, and Part 2: ACRS Reports on Generic Subjects. Part I contains ACRS reports alphabetized by project name and by chronological order within project name. Part 2 categorizes the reports by the most appropriate generic subject area and by chronological order within subject area.

1993-04-01

360

A compilation of reports of the Advisory Committee on Reactor Safeguards: 1991 annual

This compilation contains 41 Advisory Committee on Reactor Safeguards (ACRS) reports submitted to the Commission, Executive Director for Operations, or to the Office of Nuclear Regulatory Research, during calendar year 1991. It also includes a report to the Congress on the NRC Safety Research Program. All reports have been made available to the public through the NRC Public Document Room and the US Library of Congress. The reports are divided into two groups: Part 1: ACRS Reports on Project Reviews, and Part 2: ACRS Reports on Generic Subjects. Part 1 contains ACRS reports alphabetized by project name and by chronological order within project name. Part 2 categorizes the reports by the most appropriate generic subject area and by chronological order within subject area.

1992-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Update of the management strategy for Oak Ridge National Laboratory Liquid Low-Level Waste

This compilation contains 41 Advisory Committee on Reactor Safeguards (ACRS) reports submitted to the Commission, Executive Director for Operations, or to the Office of Nuclear Regulatory Research, during calendar year 1991. It also includes a report to the Congress on the NRC Safety Research Program. All reports have been made available to the public through the NRC Public Document Room and the US Library of Congress. The reports are divided into two groups: Part 1: ACRS Reports on Project Reviews, and Part 2: ACRS Reports on Generic Subjects. Part 1 contains ACRS reports alphabetized by project name and by chronological order within project name. Part 2 categorizes the reports by the most appropriate generic subject area and by chronological order within subject area.

1992-04-01

362

Uncertainty and Sensitivity of Alternative Rn-222 Flux Density Models Used in Performance Assessment

The strategy for management of the Oak Ridge National Laboratory`s (ORNL) radioactively contaminated liquid waste was reviewed in 1991. The latest information available through the end of 1990 on waste characterization, regulations, US Department of Energy (DOE) budget guidance, and research and development programs was evaluated to determine how the strategy should be revised. Few changes are needed to update the strategy to reflect new waste characterization, research, and regulatory information. However, recent budget guidance from DOE indicates that minimum funding will not be sufficient to accomplish original objectives to upgrade the liquid low-level waste (LLLW) system to comply with the Federal Facilities Agreement, provide long-term LLLW treatment capability, and minimize environmental, safety, and health risks. Options are presented that might allow the ORNL LLLW system to continue operations temporarily, but they would significantly reduce its ...

1995-04-01

363

TRANSPORT CHARACTERISTICS OF REPRESENTATIVE DEBRIS IN A OPEN CHANNEL

Performance assessments for the Area 5 Radioactive Waste Management Site on the Nevada Test Site have used three different mathematical models to estimate Rn-222 flux density. This study describes the performance, uncertainty, and sensitivity of the three models which include the U.S. Nuclear Regulatory Commission Regulatory Guide 3.64 analytical method and two numerical methods. The uncertainty of each model was determined by Monte Carlo simulation using Latin hypercube sampling. The global sensitivity was investigated using Morris one-at-time screening method, sample-based correlation and regression methods, the variance-based extended Fourier amplitude sensitivity test, and Sobol's sensitivity indices. The models were found to produce similar estimates of the mean and median flux density, but to have different uncertainties and sensitivities. When the Rn-222 effective diffusion coefficient was estimated using five different ...

2007-06-01

364

Sump Pool Flow Simulation during Fill-up Phase of LOCA Using on CFD for OPR1000 Plant

During LOCA(Loss of Coolant Accident), emergency core coolant supplements form a recirculation sump and cooled core and containment. When the double ended guillotine Break (DEGB) at the hot leg near steam generator, due to the jet impingement discharge flow, the debris could be potentially generated at pipe or wall nearby steam generator and be transported to the recirculation sump. Therefore, the debris could be accumulated and be clogged in the recirculation sump screen. If debris blocked the sump screen, the pressure drop increased at the screen so as to increase the pressure loss of ECCS (Emergency Core Cooling System) pump NPSH (Net positive suction head). It is potentially influenced to decrease the long-term cooling capability of the recirculation sump. The recirculation sump screen clogging accident has happened in BWR at 1990. Considering the important of safety, US NRC published Regulatory Guide 1.82 Rev.3 incorporating the R and D findings and ...

2010-05-15

365

Status of the ORNL liquid low-level waste management upgrades

During LOCA (Loss of Coolant Accident) in design bases accident (DBA), emergency core coolant supplements form a recirculation sump and cooled core and containment. When the double ended guillotine Break (DEGB) at the hot leg near steam generator, due to the jet impingement discharge flow, the debris could be potentially generated at pipe or wall nearby steam generator and be transported to the recirculation sump. Therefore, the debris, such as insulations and paint chips, could be accumulated and be clogged in the recirculation sump screen. If debris is blocked the sump strainer, the pressure drop is increased at the screen so as to increase the pressure loss of ECCS (Emergency Core Cooling System) pump NPSH (Net positive suction head). It is potentially influenced to decrease the long-term cooling capability of the recirculation sump. The recirculation sump screen clogging accident has happened in BWR of USA and Sweden. Considering the important to safety, US NRC (Nuclear Safety ...

2009-10-15

366

Sources of toxicity and exposure information for identifying chemicals of high concern to children

The strategy for management of the Oak Ridge National Laboratory`s (ORNL`s) radioactively contaminated liquid waste was reviewed. The latest information on waste characterization, regulations, US Department of Energy (DOE) budget guidance, and research and development programs was evaluated to determine how the strategy should be revised. Few changes are needed to update the strategy to reflect new waste characterization, research, and regulatory information. However, recent budget guidance from DOE indicates that minimum funding will not be sufficient to accomplish original objectives to upgrade the liquid low-level waste (LLLW) system to be in compliance with the Federal Facilities Agreement compliance, provide long-term LLLW treatment capability, and minimize Environmental Safety & Health risks. Options are presented that might allow the ORNL LLLW system to continue operations temporarily but significantly reduce its capabilities to handle emergency ...

1995-08-01

367

Risk assessment of severe accident-induced steam generator tube rupture

Due to the large number of chemicals in commerce without adequate toxicity characterization data, coupled with an ineffective federal policy for chemical management in the United States, many states are grappling with the challenge to identify toxic chemicals that may pose a risk to human health and the environment. Specific populations (e.g., children, elderly) are particularly sensitive to these toxic chemicals. In 2008, the Children's Safe Product Act (CSPA) was passed in Washington State. The CSPA included specific requirements to identify High Priority Chemicals (HPCs) and Chemicals of High Concern to Children (CHCCs). To implement this legislation, a methodology was developed to identify HPCs from authoritative scientific and regulatory sources on the basis of toxicity criteria. Another set of chemicals of concern was then identified from authoritative sources, based on their potential exposure to children. Exposure potential was evaluated by identifying ...

2010-11-01

368

Review of UCN 3,4 PSA model based on NEI PRA peer review process guidance, rev.0

This report describes the basis, results, and related risk implications of an analysis performed by an ad hoc working group of the U.S. Nuclear Regulatory Commission (NRC) to assess the containment bypass potential attributable to steam generator tube rupture (SGTR) induced by severe accident conditions. The SGTR Severe Accident Working Group, comprised of staff members from the NRC`s Offices of Nuclear Reactor Regulation (NRR) and Nuclear Regulatory Research (RES), undertook the analysis beginning in December 1995 to support a proposed steam generator integrity rule. The work drew upon previous risk and thermal-hydraulic analyses of core damage sequences, with a focus on the Surry plant as a representative example. This analysis yielded new results, however, derived by predicting thermal-hydraulic conditions of selected severe accident scenarios using the SCDAP/RELAP5 computer code, flawed tube failure modeling, and tube failure probability ...

1998-03-01

369

Review of UCN 3,4 PSA model based on NEI PRA peer review process guidance, rev.0

Recently, under the de-regulation environment, nuclear industry has attempted various approaches to improve the economics of Nuclear Power Plants (NPP). One of these efforts is the Risk Informed/Performance-Based Operation (RIPBO). This approach uses the risk and performance information to manage the resources effectively and efficiently that are used in the operation of NPP. In RIPBO, PSA quality is one of the most important things. The nuclear industry and regulatory body of U.S.A have developed a measure to evaluate the quality of PSA. NEI (Nuclear Energy Institute) has developed a guidance called 'NEI PRA Peer Review Guidance,' and NRC (Nuclear Regulatory Committee) and ASME have developed the 'PRA Standard.' In Korea, several projects are on going now, such as the extension of AOT/STI of RPS/ESFAS, Risk-Informed In-Service Inspection (RI-ISI). However, in Korea, there have been no attempts to evaluate the quality of PSA model itself. ...

2004-10-03

370

Review of UCN 3,4 PSA model based on ASME PRA standard rev.0

Recently, under the de-regulation environment, nuclear industry has attempted various approaches to improve the economics of Nuclear Power Plants (NPP). One of these efforts is the Risk Informed/Performance-Based Operation (RIPBO). This approach uses the risk and performance information to manage the resources effectively and efficiently that are used in the operation of NPP. In RIPBO, PSA quality is one of the most important things. The nuclear industry and regulatory body of U.S.A have developed a measure to evaluate the quality of PSA. NEI (Nuclear Energy Institute) has developed a guidance called 'NEI PRA Peer Review Guidance,' and NRC (Nuclear Regulatory Committee) and ASME have developed the 'PRA Standard.' In Korea, several projects are on going now, such as the extension of AOT/STI of RPS/ESFAS, Risk-Informed In-Service Inspection (RI-ISI). However, in Korea, there have been no attempts to evaluate ...

2003-05-01

371

Review of UCN 3,4 PSA model based on ASME PRA standard rev.0

Recently, under the de-regulation environment, nuclear industry has attempted various approaches to improve the economics of Nuclear Power Plants (NPP). One of these efforts is the Risk Informed/Performance-Based operation (RIPBO). This approach uses the risk and performance information to manage the resources effectively and efficiently that are used in the operation of NPP. In RIPBO, PSA quality is one of the most important things. The nuclear industry and regulatory body of U.S.A have developed a measure to evaluate the quality of PSA. NEI (Nuclear Energy Institute) has developed a guidance called 'NEI PRA Peer Review Guidance,' and NRC (Nuclear Regulatory Committee) and ASME have developed the 'PRA Standard.' In Korea, several projects are on going now, such as the extension of AOT/STI of RPS/ESFAS, Risk-Informed In-Service Inspection (RI-ISI). However, in Korea, there have been no attempts to evaluate the quality of PSA model itself. ...

2011-03-13

372

Review of KSNP LPSD PSA model based of ANS LPSD PRA standard, rev.0

Recently, under the de-regulation environment, nuclear industry has attempted various approaches to improve the economics of Nuclear Power Plants (NPP). One of these efforts is the Risk Informed/Performance-Based operation (RIPBO). This approach uses the risk and performance information to manage the resources effectively and efficiently that are used in the operation of NPP. In RIPBO, PSA quality is one of the most important things. The nuclear industry and regulatory body of U.S.A have developed a measure to evaluate the quality of PSA. NEI (Nuclear Energy Institute) has developed a guidance called 'NEI PRA Peer Review Guidance,' and NRC (Nuclear Regulatory Committee) and ASME have developed the 'PRA Standard.' In Korea, several projects are on going now, such as the extension of AOT/STI of RPS/ESFAS, Risk-Informed In-Service Inspection (RI-ISI). However, in Korea, there have been no attempts to evaluate ...

2003-05-01

373

Reference neutron transport calculation note for Korea nuclear power plants with 3-loop PWR reactors

Recently, under the de-regulation environment, nuclear industry has attempted various approaches to improve the economics of Nuclear Power Plants (NPP). One of these efforts is the Risk Informed/Performance-based Operation (RIPBO). This approach uses the risk and performance information to manage the resources effectively and efficiently that are used in the operation of NPP. In RIPBO, PSA quality is one of the most important things. The nuclear industry and regulatory body of U.S.A have developed a measure to evaluate the quality of PSA. NEI (Nuclear Energy Institute) has developed a guidance called 'NEI PRA Peer Review Guidance,' and NRC (Nuclear Regulatory Committee) and ASME have developed the 'PRA Standard.' In Korea, several projects are on going now, such as the extension of AOT/STI of RPS/ESFAS, Risk-informed In-service Inspection (RI-ISI). However, in Korea, there have been no attempts to evaluate ...

2004-02-01

374

Radionuclide air emissions report for the Hanford Site -- calendar year 1997

Reactor pressure vessel (RPV) steels are subjected to neutron irradiation at a temperature of about 290 deg C. This radiation exposure alters the mechanical properties, leading to a shift of the brittle-to-ductile transition temperature toward higher temperatures and to a diminution of the rupture energy as determined by Charpy V-notch tests. This radiation embrittlement is one of the important aging factors of nuclear power plants. U.S. NRC recommended the basic requirements for the determination of the pressure vessel fluence by regulatory guide DG-1025 in order to reduce the uncertainty in the determination of neutron fluence calculation and measurements. The determination of the pressure vessel fluence is based on both calculations and measurements. The fluence prediction is made with a calculation and the measurements are used to qualify the calculational methodology. Because of the importance and the difficulty of these calculations, the method`s ...

1997-05-01

375

Potential for oil shale development in the United States

This report documents radionuclide air emission from the Hanford Site in 1997, and the resulting effective dose equivalent to the maximally exposed member of the public, referred to as the MEI. The report has been prepared in accordance with reporting requirements in the Code of Federal Regulations, Title 40, Protection of the Environment, Part 61, National Emissions Standards for Hazardous Air Pollutants, Subpart H, National Emission Standards for Emissions of Radionuclides Other than Radon from Department of Energy Facilities. This report has also been prepared in accordance with the reporting requirements of the Washington Administrative Code Chapter 246-247, Radiation Protection-Air Emissions. The effective dose equivalent to the MEI from the Hanford Site`s 1997 point source emissions was 1.2 E-03 mrem (1.2 E-05 mSv), which is well below the 40 CFR 61 Subpart H regulatory limit of 10 mrem/yr. Radon and thoron emissions, exempted from 40 CFR 61 Subpart H, ...

1998-06-17

376

Optical Fiber Sensor Package Development for the SIT of Containment Structure

Over the past few years, the development of domestic oil shale resources has regained significant attention. High oil prices, emerging recovery technologies, increasing world demand for liquid hydrocarbons, and the continued decline in United States conventional oil production has contributed to this interest. Several initiatives have been undertaken by the United States federal government and the private sector to encourage the development of a domestic oil shale industry. The United States has nearly 2.0 trillion barrels of oil shale resources across the eastern and western states. However, the development of this massive resource is constrained by a number of key factors, such as resource access, technology, economics, infrastructure and environmental and regulatory issues. In order to review emerging oil shale technologies from 23 companies and identify options to accelerate the development of this resource, a comprehensive analysis has been completed. This ...

2009-07-01

377

Laser Sensor Package Development for the SIT of Containment Structure

Various types of nuclear power plants are being constructed and operated in Korea, and in terms of regulatory control, a method of examining and evaluating the structural integrity of containment structure is being used. Generally, after the construction has been completed, all containment structure go through a Structural Integrity Test(hereinafter SIT) in which the displacement occurring in a structure under greater internal pressure than it was designed for is measured and the result is comparatively assessed with the allowed criteria. Most of the nuclear power plants in Korea are American type plants and their SIT uses the Invar-wire and Extensometer methods. These existing methods are expected to be used for the APR1400 plant currently being built unless some other reliable alternative technique is presented. This tendency can be observed in other countries, such as Japan, and there is thus insufficient effort to enhance the reliability of SIT through the ...

2010-10-01

378

Insights from Guideline for Performance of Internal Flooding Probabilistic Risk Assessment (IFPRA)

Various types of nuclear power plants are being constructed and operated in Korea, and in terms of regulatory control, a method of examining and evaluating the structural integrity of containment structure is being used. Generally, after the construction has been completed, all containment structure go through a Structural Integrity Test(hereinafter SIT) in which the displacement occurring in a structure under greater internal pressure than it was designed for is measured and the result is comparatively assessed with the allowed criteria. Most of the nuclear power plants in Korea are American type plants and their SIT uses the Invar-wire and Extensometer methods. These existing methods are expected to be used for the APR1400 plant currently being built unless some other reliable alternative technique is presented. This tendency can be observed in other countries, such as Japan, and there is thus insufficient effort to enhance the reliability of SIT through the ...

2010-10-01

379

Geology, public policy, and the North Carolina low level radioactive waste (LLRW) disposal facility project

An internal flooding (IF) risk assessment refers to the quantitative probabilistic safety assessment (PSA) treatment of flooding as a result of pipe and tank breaks inside the plants, as well as from other recognized flood sources. The industry consensus standard for Internal Events Probabilistic Risk Assessment (ASME-RA-Sb-2005) includes high-level and supporting technical requirements for developing internal flooding probabilistic risk assessment (IFPRA). This industry standard is endorsed in Regulatory Guide 1.200, Revision 1 as an acceptable approach for addressing the risk contribution from IF events for risk informed applications that require U.S. Nuclear Regulatory commission (NRC) approval. In 2006, EPRI published a draft report for IFPRA that addresses the requirements of the ASME PRA consensus standard and have made efforts to refine and update the final EPRI IFPRA guideline. Westinghouse has performed an IFPRA analysis for several ...

2009-10-15

380

Formation of non-extractable pesticide residues: observations on compound differences, measurement and regulatory issues

North Carolina is in the process of siting a LLRW disposal facility as the next host state for the Southwest Compact. After two years of site characterization studies at two technically challenging sites, the LLRW Management Authority (the Authority), will submit a license application for the preferred site. One potential site is in unconsolidated Tertiary and Cretaceous deposits of the inner Coastal Plain, the other in fractured sedimentary rocks of the Triassic Deep River Basin. Involved since 1986, the North Carolina Geological Survey (NCGS) provides technical advice to the Division of radiation Protection, the state regulatory agency authorized to approve or deny a license. With the multi-million dollar project behind schedule, and millions of dollars over budget, in February 1992 the Southeast Compact Commission established three project milestones (1) submit license application by December 31, 1993; (2) approve license by March 15, 1994; (3) open facility by ...

1994-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

381

Fire preventive materials for nuclear power plants

Six major use pesticides (Atrazine, Dicamba, Isoproturon, Lindane, Paraquat and Trifluralin) with differing physico-chemical properties were evaluated for the significance of 'bound' or non extractable residue formation. Investigations were carried out in purpose-built microcosms where mineralization, volatilisation, 'soil water' extractable and organic solvent extractable residues could be quantified. Extractable residues were defined as those accessible by sequential extraction where the solvent used became increasingly non-polar. Dichloromethane was the 'harshest' solvent used at the end of the sequential extraction procedure. {sup 14}C-labelled volatilised and {sup 14}CO{sub 2} fractions were trapped on exit from the microcosm. The pesticides were categorised into 3 classes based on their behaviour. (i) Type A (Atrazine, Lindane and Trifluralin) in which ring degradation was limited as was the formation of non-extractable ...

2005-01-01

382

Final report for SNL/NM environmental drilling project

With the fire accident in Browns Ferry nuclear power plant as a turning point, the regulation against fire has been strengthened more strictly as seen in the regulatory guide of the United States Nuclear Regulatory Commission. Fire of cables is caused by either the ignition of a cable itself or spread of fire to cables. The aspect of fire is divided into the local ignition and combution and the fire extension and prepagation because of the line-shaped configuration of cables. This report describes the prevention of the spread of fire. As the materials for the prevention of fire spread, fire spread-preventing paint ''Dannekka'', sealant ''Danseal P and L'', and fire prevention tape ''FD tape'' are reported, and the testing method and the results are described in detail. ''Dannekka'' is classified into the solvent dispersion type and the water dispersion type. It may be coated with brush or by spraying. Seal material is required not only to be ...

383

Environmental, health, and safety issues of sodium-sulfur batteries for electric and hybrid vehicles

Concern for the environment and cost reduction are driving forces for a broad effort in government and the private sector to develop new, more cost-effective technologies for characterizing, monitoring and remediating environmental sites. Secondary goals of the characterization, monitoring and remediation (CMR) activity are: minimize secondary waste generation, minimize site impact, protect water tables, and develop methods/strategies to apply new technologies. The Sandia National Laboratories (SNL) project in directional boring for CMR of waste sites with enhanced machinery from the underground utility installation industry was initiated in 1990. The project has tested a variety of prototype machinery and hardware built by the industrial partner, Charles Machine Works (CMW), and SNL at several sites (Savannah River Site (SRS), Hanford, SNL, Kirtland AFB (KAFB), CMW), successfully installed usable horizontal environmental test wells at SRS and SNL/KAFB, and functioned as a clearing ...

1994-11-01

384

Ecological risks associated with the application of sewage sludge to non-agricultural ecosystems

Recycling and disposal of spent sodium-sulfur (Na/S) batteries are important issues that must be addressed as part of the commercialization process of Na/S battery-powered electric vehicles. The use of Na/S batteries in electric vehicles will result in significant environmental benefits, and the disposal of spent batteries should not detract from those benefits. In the United States, waste disposal is regulated under the Resource Conservation and Recovery Act (RCRA). Understanding these regulations will help in selecting recycling and disposal processes for Na/S batteries that are environmentally acceptable and cost effective. Treatment processes for spent Na/S battery wastes are in the beginning stages of development, so a final evaluation of the impact of RCRA regulations on these treatment processes is not possible. The objectives of tills report on battery recycling and disposal are as follows: Provide an overview of RCRA regulations and requirements as they apply to Na/S battery ...

1992-09-01

385

Development of quality assurance requirements as part of the regulatory framework in the United Kingdom

The Clean Water Act of 1977 directed EPA to establish standards for use and disposal of sewage sludge (biosolids). The application of biosolids to non-agricultural lands is becoming increasingly important as a method of waste disposal. Ecological endpoints at the population, community, and/or ecosystem level have not previously been emphasized in the development of regulatory standards for municipal sewage sludge. This risk assessment focuses on terrestrial endpoints in four ecosystem types to which substantial quantities of sludge have been applied or are expected to be applied in the future: northwest Douglas-fir forest, southeastern loblolly pine plantation, eastern deciduous forest, and semi-arid rangeland. Conceptual models suitable for all ecosystems were developed that depict the links among assessment endpoints. Estimates of risks to wildlife from contaminants and simulations of impacts of nitrogen in sewage sludge on the structure and function of forest ...

1995-12-31

386

Decommissioning of U.S. uranium production facilities

Within the United Kingdom, the regulatory body having responsibility for the licensing of nuclear installations is the Health and Safety Executive (HSE). The Nuclear Installations Inspectorate (NII) is that part of HSE which administers this function. Discussions on the applicability of quality assurance (QA) to licensed sites began in 1974, and an internal report was published in 1975. In parallel with work going on at the International Atomic Energy Agency (IAEA) to prepare Quality Assurance for Safety in Nuclear Power Plants: A Code of Practice, Safety Series No. 50-C-QA, NII published a second report in 1978 entitled A Guide to the Quality Assurance Programme for Nuclear Power Plants. In 1980, the construction of advanced gas cooled reactors at Heysham 2 and at Torness was licensed, and a condition was attached to the licences requiring the licensees to submit their QA arrangements to the NII for approval. The licensees' response was to produce separate QA ...

1988-11-07

387

Computational identification of developmental enhancers:conservation and function of transcription factor binding-site clustersin drosophila melanogaster and drosophila psedoobscura

From 1980 to 1993, the domestic production of uranium declined from almost 44 million pounds U{sub 3}O{sub 8} to about 3 million pounds. This retrenchment of the U.S. uranium industry resulted in the permanent closing of many uranium-producing facilities. Current low uranium prices, excess world supply, and low expectations for future uranium demand indicate that it is unlikely existing plants will be reopened. Because of this situation, these facilities eventually will have to be decommissioned. The Uranium Mill Tailings and Radiation Control Act of 1978 (UMTRCA) vests the U.S. Environmental Protection Agency (EPA) with overall responsibility for establishing environmental standards for decommissioning of uranium production facilities. UMTRCA also gave the U.S. Nuclear Regulatory Commission (NRC) the responsibility for licensing and regulating uranium production and related activities, including decommissioning. Because there are many issues associated with ...

1995-02-01

388

Characterization of the human lipoprotein lipase (LPL) promoter: Evidence of two cis-regulatory regions, LP-[alpha] and LP-[beta] of importance for the differentation-linked induction of the LPL gene during adipogenesis

Background The identification of sequences that control transcription in metazoans is a major goal of genome analysis. In a previous study, we demonstrated that searching for clusters of predicted transcription factor binding sites could discover active regulatory sequences, and identified 37 regions of the Drosophila melanogaster genome with high densities of predicted binding sites for five transcription factors involved in anterior-posterior embryonic patterning. Nine of these clusters overlapped known enhancers. Here, we report the results of in vivo functional analysis of 27 remaining clusters. Results We generated transgenic flies carrying each cluster attached to a basal promoter and reporter gene, and assayed embryos for reporter gene expression. Six clusters are enhancers of adjacent genes: giant, fushi tarazu, odd-skipped, nubbin, squeeze and pdm2; three drive expression in patterns unrelated to those of neighboring genes; the remaining 18 do not appear ...

2004-08-06

389

Regulatory Framework for Advanced Fuel Cycle Facility Using Pyroprocess in Korea

When preadipocytes differentiate into adipocytes, several differentiation-linked genes are activated. Lipo-protein lipase (LPL) is one of the first genes induced during this process. To investigate early events in adipocyte development, we have focused on the transcriptional activation of the LPL gene. For this purpose, we have cloned and fused different parts of intragenic and flanking sequences with a chloramphenicol acetyltransferase reporter gene. Transient transfection experiments and DNase I hypersensitivity assays indicate that several positive as well as negative elements contribute to transcriptional regulation of the LPL gene. When reporter gene constructs were stably introduced into preadipocytes, we were able to monitor and compare the activation patterns of different promoter deletion mutants at selected time points representing the process of adipocyte development. We could delimit two cis-regulatory elements important for gradual activation of the ...

1992-10-01

390

Why (and how) to regulate power exchanges in the EU market integration context?

Nuclear power plants of 20 units of in Korea are generating about 700 MTU of spent fuels annually. The inventory of spent fuels in Korea were estimated about 10,087.07 MTU at end of 2008, and the storage space of spent fuels won't be available any more at 2016 due to the saturation of the spent fuel pools in the plants. In addition, in order to reduce carbon emission and correspond to the enormous electricity demand in Korea, 8 units of nuclear power plants are under construction and several more plants are under planning. The 100,000 MTU of spent fuel inventory are expected by the year of 2095 in Korea. Therefore, short term and long term of spent fuel management plans are under discussion and implementation in Korea. As a short term of spent fuel management strategy for the target year of 2016, central or local spent fuel dry interim storage options are mostly under discussion. As a long term of management plan, fast reactor and advanced fuel cycle R and D plan were approved by 255th ...

2010-10-01

391

Wetlands - A valuable resource for the '90s

The European Union (EU) market integration is leading to increasingly monopolistic electricity market infrastructures, which has opened a debate on the regulation of these so-called power exchanges. In this paper, we start by stating that there are two types of power exchanges in Europe, i.e. 'merchant' and 'cost-of-service regulated' power exchanges. We then discuss how regulation can be used to better align their incentives with the main power exchange tasks. We conclude that adopting the cost-of-service regulated model for all power exchanges in Europe could be counterproductive in the current context, but that regulation can help ensure that the benefits of the EU market integration materialize. Promising regulatory actions include tempering the reinforced market power of power exchanges, and quality-of-service regulation for the ongoing cooperation among power exchanges to organize trade across borders. - Research highlights: #-># Market integration is ...

2011-03-01

392

Unsaturated zone flow modeling for GWTT-95

The nation's wetlands are a valuable resource serving many important natural, industrial, commercial and recreational functions. Wetlands protect shore areas from waves and storms; act as storage areas for flood waters; remove waste from water by trapping soils or silt which settle to the bottom; improve water quality and reduce pollution; are a commercial breeding ground for fish and other foods; and provide space for recreation and habitat for wildlife. They also are located in prime industrial development areas. Recent wetlands losses have caused much public outcry, politicking and regulatory efforts to prevent this trend. During the '90s, the public will see efforts to strike a proper balance regarding wetlands use. Today, wetlands protection is a permitting issue for nearly every major industrial or commercial development and expansion project. Wetlands permit requirements affect a range of business entities. Any project that involves ...

1993-04-15

393

Unrestricted disposal of minimal activity levels of radioactive wastes: exposure and risk calculations

In accordance with the Nuclear Regulatory Commission regulation regarding groundwater travel times at geologic repositories, various models of unsaturated flow in fractured tuff have been developed and implemented to assess groundwater travel times at the potential repository at Yucca Mountain, Nevada. Kaplan used one-dimensional models to describe the uncertainty and sensitivity of travel times to various processes at Yucca Mountain. Robey and Arnold et al. used a two-dimensional equivalent continuum model (ECM) with inter- and intra-unit heterogeneity in an attempt to assess fast-flow paths through the unsaturated, fractured tuff at Yucca Mountain (GWTT-94). However, significant flow through the fractures in previous models was not simulated due to the characteristics of the ECM, which requires the matrix to be nearly saturated before flow through the fractures is initiated. In the current study (GWTT-95), four two-dimensional cross-sections at Yucca Mountain are ...

1995-12-31

394

Transcriptome analysis reveals salt-stress-regulated biological processes and key pathways in roots of cotton (Gossypium hirsutum L.).

The US Nuclear Regulatory Commission is currently considering revision of rule 10 CFR Part 20, which covers disposal of solid wastes containing minimal radioactivity. In support of these revised rules, we have evaluated the consequences of disposing of four waste streams at four types of disposal areas located in three different geographic regions. Consequences are expressed in terms of human exposures and associated health effects. Each geographic region has its own climate and geology. Example waste streams, waste disposal methods, and geographic regions chosen for this study are clearly specified. Monetary consequences of minimal activity waste disposal are briefly discussed. The PRESTO methodology was used to evaluate radionuclide transport and health effects. This methodology was developed to assess radiological impacts to a static local population for a 1000-year period following disposal. Pathways and processes of transit from the trench to exposed ...

1984-08-01

395

Theory and evidence of economies of scale in the development of waste management systems

High salinity is one of the main factors limiting cotton growth and productivity. The genes that regulate salt stress in TM-1 upland cotton were monitored using microarray and real-time PCR (RT-PCR) with samples taken from roots. Microarray analysis showed that 1503 probe sets were up-regulated and 1490 probe sets were down-regulated in plants exposed for 3h to 100mM NaCl, and RT-PCR analysis validated 42 relevant/related genes. The distribution of enriched gene ontology terms showed such important processes as the response to water stress and pathways of hormone metabolism and signal transduction were induced by the NaCl treatment. Some key regulatory gene families involved in abiotic and biotic sources of stress such as WRKY, ERF, and JAZ were differentially expressed. Our transcriptome analysis might provide some useful insights into salt-mediated signal transduction pathways in cotton and offer a number of candidate genes as potential markers of tolerance to ...

2011-04-30

396

The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria.

Waste is a cost of doing business. This cost can be considered in terms of the potential adverse health and environmental impacts, or the waste management costs associated with avoiding, minimizing, and controlling those impacts. There is an anticipated increase in the cost of waste management as a result of the increasing requirements for regulatory compliance. To meet the total waste management capacity needs of the organization and the compliance requirements, low-level radioactive, hazardous, and mixed waste management will need demonstrated technologies strategically managed as a technology portfolio. The role of the decision maker is to select the optimum mix of technologies and facilities to provide the waste management capacity needed for the next twenty years. The waste management system resulting from this mix includes multiple small-scale fixed facilities, large-scale centralized facilities, and waste management subcontracts. This study was conducted to ...

1989-01-01

397

The Thai-Canadian nuclear human resources development linkage project

This is an independent reanalysis of a randomised, placebo-controlled parallel-group study on the efficacy and tolerability of a special butterbur root extract (Petadolex) for the prophylaxis of migraine. The original protocol and analysis had a number of major shortcomings. In order to follow regulatory requirements, an independent reanalysis of the original data was performed. Following a 4-week baseline phase, 33 patients were randomised to treatment with two capsules 25 mg butterbur twice a day and 27 to placebo. The mean attack frequency per month decreased from 3.4 at baseline to 1.8 after 3 months (p = 0.0024) in the verum group and from 2.9 to 2.6 in the placebo group (n.s.). The responder rate (improvement of migraine frequency > or =50%) was 45% in the verum group and 15% in the placebo group. Butterbur was well tolerated. This small trial indicates that butterbur may be effective in the prophylaxis of migraine. PMID:14752215

2004-01-28

398

The Structure of Sucrose Phosphate Synthase from Halothermothrix orenii Reveals Its Mechanism of Action and Binding Mode

The Thai-Canadian Nuclear Human Resources Development Linkage Project (the ''Project'') was initiated in 1994 in order to develop the engineering and scientific expertise needed for Thailand to decide whether and how the country can best benefit from the establishment of a nuclear power program. The Project was designed to upgrade current academics and people in industry, and to develop an adequate supply of new technical personnel for academic, industry, utility, regulatory and other government institutions. The key Project objectives included the establishment of a Chair in Nuclear Engineering at Chulalongkorn University, the upgrading of the current Masters level curriculum, the establishment of undergraduate and doctorate level curricula, development and delivery of an industrial training program for people in industry and government, exchanges of Thai and Canadian academics and industry experts to establish common research ...

1998-07-01

399

The Role of the UK Planning System in Protecting and Enhancing Soils

Sucrose phosphate synthase (SPS) catalyzes the transfer of a glycosyl group from an activated donor sugar, such as uridine diphosphate glucose (UDP-Glc), to a saccharide acceptor D-fructose 6-phosphate (F6P), resulting in the formation of UDP and D-sucrose-6'-phosphate (S6P). This is a central regulatory process in the production of sucrose in plants, cyanobacteria, and proteobacteria. Here, we report the crystal structure of SPS from the nonphotosynthetic bacterium Halothermothrix orenii and its complexes with the substrate F6P and the product S6P. SPS has two distinct Rossmann-fold domains with a large substrate binding cleft at the interdomain interface. Structures of two complexes show that both the substrate F6P and the product S6P bind to the A-domain of SPS. Based on comparative analysis of the SPS structure with other related enzymes, the donor substrate, nucleotide diphosphate glucose, binds to the B-domain of SPS. Furthermore, we propose a ...

2008-01-01

400

Environmental Research Database

Summary'THE ROLE OF THE UK PLANNING SYSTEM IN PROTECTING AND ENHANCING SOILS PROJECT REF: UKLQ01 APRIL 2004 INTRODUCTION Soil has long been overlooked in environmental planning. Whilst it has sometimes benefited from indirect protection, until recently its importance and vulnerability have not been reflected in more explicit strategies. This study explored the current and potential role of the planning system in protecting and enhancing soils. Soil is the physical material that covers much o [continued...]DescriptionSNIFFER has commissioned this study on behalf of SEPA, SNH, EHS and the Environment Agency for England and Wales. These UK agencies have an interest in protecting soil quality through a combination of direct regulation of emissions to land, protection of designated sites of special value or sensitivity and engaging other regulatory regimes such as land use planning. All UK environment agencies devote considerable resources to engaging the planning ...

2003-01-31

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401

The RADionuclide transport, removal, and dose (RADTRAD) code

The RADionuclide Transport, Removal, and Dose (RADTRAD) code

The RADionuclide Transport, Removal, And Dose (RAD-TRAD) code is designed for U.S. Nuclear Regulatory Commission (USNRC) use to calculate the radiological consequences to the off-site population and to control room operators following a design-basis accident at light water reactor (LWR) power plants. This code utilizes updated reactor accident source terms published in draft NUREG-1465. The code will track the transport of radionuclides as they are released from the reactor pressure vessel, travel through the primary containment and other buildings, and are released to the environment. As the radioactive material is transported through the primary containment and other buildings, credit for several removal mechanisms may be taken, including sprays, suppression pools, overlying pools, filters, and natural deposition. Simple models are available for these different removal mechanisms that use, as input, information about the conditions in the plant and predict either ...

1993-11-14

402

The Performance of Spent Fuel Casks in Severe Tunnel Fires

The RADionuclide Transport, Removal, And Dose (RADTRAD) code is designed for US Nuclear Regulatory Commission (USNRC) use to calculate the radiological consequences to the offsite population and to control room operators following a design-basis accident at Light Water Reactor (LWR) power plants. This code utilizes updated reactor accident source terms published in draft NUREG-1465, ``Accident Source Terms for Light-Water Nuclear Power Plants.`` The code will track the transport of radionuclides as they are released from the reactor pressure vessel, travel through the primary containment and other buildings, and are released to the environment. As the radioactive material is transported through the primary containment and other buildings, credit for several removal mechanisms may be taken including sprays, suppression pools, overlying pools, filters, and natural deposition. Simple models are available for these different removal mechanisms that use, as input, ...

1993-07-01

403

The Environmental Impact Statement and its role in the nuclear licensing procedure; Umweltvertraeglichkeitspruefung im atomrechtlichen Genehmigungsverfahren

The Nuclear Regulatory Commission (NRC), working with the National Institute of Standards and Technology (NIST), Pacific Northwest National Laboratory (PNNL), and the National Transportation Safety Board (NTSB), performed analyses to predict the response of various spent fuel transportation cask designs when exposed to a fire similar to that which occurred in the Howard Street railroad tunnel in downtown Baltimore, Maryland on July 18, 2001. The thermal performance of three different spent fuel cask designs (HOLTEC HI-STAR 100, TransNuclear TN-68, and NAC-LWT) was evaluated with the ANSYSR and COBRA-SFS analysis codes, utilizing boundary conditions for the tunnel fire obtained using NIST's Fire Dynamics Simulator (FDS) code. NRC Staff evaluated the potential for a release of radioactive material from each of the three transportation casks analyzed for the Baltimore tunnel fire scenario. The results of these analyses are described in detail in Spent Fuel ...

2005-11-01

404

Technical requirements for the ASME PRA standard for nuclear power plant applications

The author discusses the implementation in Germany of the EC Directive on Environmental Impact Statements in the light of the legal tradition and concepts of law in Germany, especially in the context of the nuclear licensing procedure. His analysis reveals some legal provisions and legal concepts in existing German law that will have to be ``sacrificed`` in order to do justice to the European Union, as in the formation of the body of EC law governing environmental issues, the Anglo-Saxon approach to regulatory law has been the prevailing line of orientation (the EU ecological audit being an example). On the whole, however, the implementation of the EU Directive will not lead to substantial changes beyond procedural modifications. (HP) [Deutsch] Der Autor diskutiert die Umsetzung der EG-Richtlinien in deutsche Rechtstraditionen und -vorstellungen, besonders beim atomrechtlichen Genehmigungsverfahren. Dabei seien Abstriche an deutsche Rechtsvorschriften der Preis der ...

1995-12-31

405

Technical requirements for the ASME PRA standard for nuclear power plant applications

In 1998 the American Society of Mechanical Engineers (ASME) formed the Committee on Nuclear Risk Management (CNRM) and a Project Team to develop a standard on PRAs for use in risk informed applications. This ASME standard is being developed to help provide an adequate level of quality in PRAs that are being used to support ASME initiatives to risk informed in-service inspection (ISI) and in-service testing (IST) of nuclear power plant components. A related need supported by the industry and the U.S. Nuclear Regulatory Commission is to reduce the level of effort that is being expended in pilot applications of risk informed initiatives to address questions about the sufficiency of quality in the supporting PRA models. The purpose of this paper is to discuss the authors' views on some of the technical issues that were encountered in the effort to develop the ASME PRA standard. Draft 12 of this standard has been issued for comment, and is currently being ...

2000-07-01

406

Summary of comments received from workshops on radiological criteria for decommissioning

In 1998 the American Society of Mechanical Engineers (ASME) formed the Committee on Nuclear Risk Management (CNRM) and a Project Team to develop a standard on PRAs for use in risk informed applications. This ASME standard is being developed to help provide an adequate level of quality in PRAs that are being used to support ASME initiatives to risk informed in-service inspection (ISI) and in-service testing (IST) of nuclear power plant components. A related need supported by the industry and the U.S. Nuclear Regulatory Commission is to reduce the level of effort that is being expended in pilot applications of risk informed initiatives to address questions about the sufficiency of quality in the supporting PRA models. The purpose of this paper is to discuss the authors' views on some of the technical issues that were encountered in the effort to develop the ASME PRA standard. Draft 12 of this standard has been issued for comment, and is currently being finalized with ...

407

Studies on localization of calcitonin gene-related peptide (CGRP) in the thyroid-parathyroid complex.

The Nuclear Regulatory Commission (NRC) is conducting an enhanced participatory rulemaking to establish radiological criteria for site cleanup and decommissioning of NRC-licensed facilities. Open public meetings were held during 1993 in Chicago, IL, San Francisco, CA, Boston, MA, Dallas, TX, Philadelphia, PA, Atlanta, GA, and Washington, DC. Interested parties were invited to provide input on the rulemaking issues before the NRC staff develops a draft proposed rule. This report summarizes 3,635 comments categorized from transcripts of the seven workshops and 1,677 comments from 100 NRC docketed letters from individuals and organizations. No analysis or response to the comments is included. The comments reflect a broad spectrum of viewpoints on the issues related to radiological criteria for site cleanup and decommissioning. The NRC also held public meetings on the scope of the Generic Environmental Impact Statement (GEIS) during July 1993. The GEIS meetings were ...

1994-01-01

408

Storage of hazardous substances in bonded warehouses

Calcitonin gene-related peptide (CGRP) was localized by an immunocytochemical technique in the thyroid-parathyroid complexes of rat, guinea pig, rabbit, and in normal human thyroids and parathyroids. Human medullary carcinomas and parathyroid adenomas were also studied. In man and all animal species examined CGRP was present in the parafollicular cell, however, in guinea pigs only in small amounts. Except in rabbits, presence of CGRP was demonstrated in nerves of the thyroid and parathyroid capsule as well as in the nerve fibers of the capsular blood vessels. In the thyroid of guinea pigs CGRP was also noted in nerve fibers and in blood vessel walls between follicles. CGRP was also present in the parathyroid glands of rat and man, in nerve fibers localized between parathyroid cells. In rabbit the parafollicular cells between parathyroid cells also expressed CGRP immunoreactivity. No CGRP was noted in the parathyroids of the guinea pig. The proximity of parathyroid cells and CGRP ...

1987-01-01

409

Status of the surry low power and shutdown PRA

A variety of special regulations exist in Costa Rica for registration and transport of hazardous substances; these set the requirements for entry into the country and the security of transport units. However, the regulations mentioned no specific rules for storing hazardous substances. Tax deposits have been the initial place where are stored the substances that enter the country.The creation of basic rules that would be regulating the storage of hazardous substances has taken place through the analysis of regulations and national and international laws governing hazardous substances. The regulatory domain that currently exists will be established with a field research in fiscal deposits in the metropolitan area. The storage and security measures that have been used by the personnel handling the substances will be identified to be putting the reality with that the hazardous substances have been handled in tax deposits. A rule base for the storage of hazardous ...

410

Seabrook Station Level 2 PRA Update to Include Accident Management

Traditionally, probabilistic risk analyses [PRA] of severe accidents in nuclear power plants have limited themselves to consideration of the set of initiating events occurring during full power operation. However, some analyses of accident initiators during low power, shutdown, and other modes of plant operation other than full power have been performed. These studies as well as the Chernobyl accident and recent operating experience at U.S. pressurized water reactors suggested that risks during low power and shutdown could be significant. As such, the analysis of the frequencies, consequences, and risks of these accidents was identified as one task in the Nuclear Regulatory Commission staff's study of the implications of the Chernobyl accident to U.S. commercial nuclear power plants. The surry PRA project is an ongoing high priority effort at BNL [Brookhaven National Laboratory] that is expected to continue for the next several years. As the project is ongoing and ...

1990-10-01

411

Seabrook Station Level 2 PRA Update to Include Accident Management

A ground-breaking study was recently completed as part of the Seabrook Level 2 PRA update. This study updates the post-core damage phenomena to be consistent with the most recent information and includes accident management activities that should be modeled in the Level 2 PRA. Overall, the result is a Level 2 PRA that fully meets the requirements of the ASME PRA Standard with respect to modeling accident management in the LERF assessment and NRC requirements in Regulatory Guide 1.174 for considering late containment failures. This technical paper deals only with the incorporation of operator actions into the Level 2 PRA based on a comprehensive study of the Seabrook Station accident response procedures and guidance. The paper describes the process used to identify the key operator actions that can influence the Level 2 PRA results and the development of success criteria for these key operator actions. This addresses a key requirement of the ASME PRA Standard for ...

2006-07-01

412

Regulatory view of the close-out of the uranium ore mine Zirovski Vrh

A ground-breaking study was recently completed as part of the Seabrook Level 2 PRA update. This study updates the post-core damage phenomena to be consistent with the most recent information and includes accident management activities that should be modeled in the Level 2 PRA. Overall, the result is a Level 2 PRA that fully meets the requirements of the ASME PRA Standard with respect to modeling accident management in the LERF assessment and NRC requirements in Regulatory Guide 1.174 for considering late containment failures. This technical paper deals only with the incorporation of operator actions into the Level 2 PRA based on a comprehensive study of the Seabrook Station accident response procedures and guidance. The paper describes the process used to identify the key operator actions that can influence the Level 2 PRA results and the development of success criteria for these key operator actions. This addresses a key requirement of the ASME PRA Standard for ...

2006-06-04

413

Regulatory role of neuron-restrictive silencing factor in expression of TRPC1

The production of the uranium mine Zirovski Vrh ceased in 1990. The main remaining problem of the remadiation are mine and mill tailings. The uranium mine Zirovski Vrh has one mill tailings site Borst and one waste pile Jazbec. According to the Act on protection against ionising radiation and nuclear safety which was adopted by the Parliament in 2002, they are classified as radiation facilities. Slovenian Nuclear Safety Administration (SNSA) is authorised for issuing a mandatory consent to mining work. The SNSA prepared the initial proposal of content of the safety report for the mine waste pile Jazbec. In 2005, according to the detailed content of this document, the public company Zirovski Vrh Ltd prepared the safety report which was examined by an authorised expert for radiation and nuclear safety. After a careful revision of the safety evaluation report, the consensus for mining work shall be issued by the SNSA. After finishing the mining works the SNSA shall also issue a licence ...

2005-09-05

414

Regulation of macrophage accessory cell activity by mycobacteria. I. Ia expression in normal and irradiated mice infected with Mycobacterium mycroti

Neuron-restrictive silencer factor (NRSF) binds its consensus element to repress the transcription of various genes. The dominant-negative form (dnNRSF) has a hypertrophic effect on cardiogenesis through an unidentified mechanism. We examined the involvement of transient receptor potential (TRP) channel proteins, using transgenic mice overexpressing dnNRSF (dnNRSF mice). Electrophoretic mobility-shift assays revealed an interaction between NRSF and a neuron-restrictive silencer element-like sequence in intron 4 of TRPC1 genomic DNA. According to RT-PCR and Western analyses, TRPC1 was up-regulated in dnNRSF mouse heart. Transient overexpression of TRPC1 in HEK 293T cells increased the activity of the nuclear factor in activated T cells (NFAT) promoter and stimulated store-operated Ca"2"+ channel (SOCC)-mediated Ca"2"+ entry. Transfection of TRPC1 into primary cardiomyocytes increased NFAT activity, indicating a major role for TRPC1 in NFAT activation. Our findings strongly suggest that ...

2006-12-22

415

Regulation of human ribosomal RNA transcription.

CBA/Ca mice were infected by either the intravenous or intraperitoneal route with Mycobacterium microti and the subsequent changes in local macrophage populations examined. Following infection, the number of macrophages increased and they showed greater expression of both MHC Class II molecules. This response was not dependent on viability of the mycobacteria, in contrast to reports with other microorganisms such as Listeria. Studies in sublethally irradiated mice indicated that persistent antigen could give rise to a response after a period of host recovery which was radiation dose dependent. This procedure also highlighted differences in the regulation of different murine class II antigens in vivo, as seen by delayed re-expression of I-E antigens. Macrophage accessory cell function, as assessed by an in vitro T cell proliferation assay, correlated with Ia expression after fixation, but not after indomethacin treatment; this highlights the diverse nature of ...

416

Recent developments in the way forward for alternative methods: Formation of national consensus platforms in Europe

We have used a cell-free polymerase I transcription system derived from HeLa cells to study the regulation of human rRNA synthesis. Analysis of deletion mutants spanning the start site of transcription at nucleotide +1 indicates that the control region affecting initiation of human rRNA synthesis is contained within sequences from nucleotides -158 to +18. This promoter region can be subdivided into (i) a central segment of approximately 40 base pair that is required for transcription and (ii) flanking sequences that influence the efficiency of transcription in vitro. We have examined the in vitro transcriptional activity of the human extract under various conditions that are thought to modulate rRNA synthesis in vivo. Cell-free extracts prepared from HeLa cells infected with adenovirus 2 synthesize human rRNA at levels greatly decreased relative to uninfected cell extracts. By contrast, in vitro transcription of human rRNA is stimulated 2- to 3-fold by the addition of purified simian ...

1983-06-01

417

Radiological follow-up of the environment of the G.I.P. CYCERON of Caen - year 2005 - 2006 - assessment 2007; Suivi radiologique de l'environnement des installations du GIP CYCERON de Caen - annee 2005 - 2006 - bilan 2007

Ecopa, the European Consensus Platform on 3R-Alternatives, is an international not-for-profit organization that wants to stimulate the development of 3R-alternatives, increase awareness among the public, scientists and regulatory bodies, and help their implementation into the different national legislations. This is done by networking and bringing together National Consensus Platforms on 3R-alternatives. Consensus means that all parties concerned are represented, namely, animal welfare, industry, academia, and governmental institutions. Actually, 14 Member State Platforms exist. Fully complying with the criteria, set by ecopa, are the platforms of Austria, Belgium, the Czech Republic, Finland, Germany, Italy, the Netherlands, Spain, Sweden, Switzerland, and the United Kingdom. Under development are the platforms of Denmark, Norway, and Poland. To reach its goals, ecopa uses conventional scientific tools such as workshops and meetings but it also makes ...

2005-09-01

418

RCRA closure of the Building 3001 Storage Canal

The present study answers at the request of the Inspection of the classified installations to see the operator of the G.I.P. Cyceron setting up a plan of environmental radiological surveillance around its installations and including, at a minimal level, the following data: Measures of radioactivity on representative biological indicators and measures of dose rate in the environment close to installations in functioning. Further to the radiological assessment of the terrestrial environment of the G.I.P. Cyceron installations realized at the end of 2003, within the framework of a project of the installations extension, the A.C.R.O. was again required for the implementation of this radiological surveillance for year 2005. The first purpose is to supply elements of appreciation about the impact of these installations on environment and persons. This evaluation participates in radiation protection and allows to make sure that the G.I.P. operator respects the required ...

2007-07-01

419

Quality assurance requirements and description for the Civilian Radioactive Waste Management Program

The 3001 Storage Canal is located under portions of Buildings 3001 and 3019 at Oak Ridge National Laboratory (ORNL) and has a capacity of approximately 62,000 gallons of water. The term canal has historically been used to identify this structure, however, the canal is an in-ground reinforced concrete structure satisfying the regulatory definition of a tank. From 1943 through 1963, the canal in Building 3001 was designed to be an integral part of the system for handling irradiated fuel from the Oak Ridge Graphite Reactor. Because one of the main initial purposes of the reactor was to produce plutonium for the chemical processing pilot plant in Building 3019, the canal was designed to be the connecting link between the reactor and the pilot plant. During the war years, natural uranium slugs were irradiated in the reactor and then pushed out of the graphite matrix into the system of diversion plates and chutes which directed the fuel into the deep pit of the canal. ...

1992-09-01

420

Proving Stabilization of Biological Systems

The Quality Assurance Requirements and Description (QARD) is the principal quality assurance document for the Civilian Radioactive Waste Management Program (Program). It establishes the minimum requirements for the Quality Assurance Program. The QARD contains regulatory requirements and program commitments necessary for the development of an effective quality assurance program. Quality assurance implementing documents must be based on, and consistent with, QARD requirements. The QARD applies to the following: (1) acceptance of spent nuclear fuel and high-level radioactive waste; (2) transport of spent nuclear fuel and high-level radioactive waste; (3) the Monitored Retrievable Storage (MRS) facility through application for an operating license; (4) Mined Geologic Disposal System (MGDS), including the site characterization activities (exploratory studies facility (ESF) and surface based testing), through application for an operating license; (5) the high-level-waste ...

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

421

Proteomic analysis of the shistosome tegument and its surface membranes

We describe an efficient procedure for proving stabilization of biological systems modeled as qualitative networks or genetic regulatory networks. For scalability, our procedure uses modular proof techniques, where state-space exploration is applied only locally to small pieces of the system rather than the entire system as a whole. Our procedure exploits the observation that, in practice, the form of modular proofs can be restricted to a very limited set. For completeness, our technique falls back on a non-compositional counterexample search. Using our new procedure, we have solved a number of challenging published examples, including: a 3-D model of the mammalian epidermis; a model of metabolic networks operating in type-2 diabetes; a model of fate determination of vulval precursor cells in the C. elegans worm; and a model of pair-rule regulation during segmentation in the Drosophila embryo. Our results show many orders of magnitude speedup in cases where ...

2011-01-01

422

Scientific Electronic Library Online (English)

Abstract in english The tegument surface of the adult schistosome, bounded by a normal plasma membrane overlain by a secreted membranocalyx, holds the key to understanding how schistosomes evade host immune responses. Recent advances in mass spectrometry (MS), and the sequencing of the Schistosoma mansoni transcriptome/genome, have facilitated schistosome proteomics. We detached the tegument from the worm body and enriched its surface membranes by differential extraction, before subjecting t (more) he preparation to liquid chromatography-based proteomics to identify its constituents. The most exposed proteins on live worms were labelled with impearmeant biotinylation reagents, and we also developed methods to isolate the membranocalyx for analysis. We identified transporters for sugars, amino acids, inorganic ions and water, which confirm the importance of the tegument plasma membrane in nutrient acquisition and solute balance. Enzymes, including phosphohydrolases, esterases and ...

2006-10-01

423

Profiling highly conserved microrna expression in recombinant IgG-producing and parental Chinese hamster ovary cells

British Library Electronic Table of Contents (United Kingdom)

Abstract MicroRNAs (miRNAs) play important roles in global gene regulation. Researchers in recombinant protein production have proposed miRNAs as biomarkers and cell engineering targets. However, miRNA expression remains understudied in Chinese Hamster Ovary cells, one of the most commonly used host cell systems for therapeutic protein production. To profile highly conserved miRNA expression, we used the miRCURY- miRNA array for screening miRNAs in CHO cells. The selection criteria for further miRNA profiling included positive hybridization signals and experimentally validated predicted regulatory targets. On the basis of screening, we selected 16 miRNAs for quantitative RT-PCR profiling. We profiled miR expression in parental CHO DG44 and CHO K1 cell lines as well as four recombinant DG44...

2011-01-01

424

Proceedings of the 58. annual technical meeting of the Petroleum Society of CIM : CIPC 2007 : Because technology changes everything

Pricing of constraints - the England & Wales experience

This conference and trade show provided a forum to present new, emerging and existing technologies that will play a key role in ensuring that hydrocarbon exploitation occurs in a sustainable manner, where costs and resource recovery are optimized while minimizing environmental impacts. The challenge of developing maturing basins, frontier lands and unconventional resources was discussed. In particular, the application of thermal recovery methods such as steam assisted gravity drainage (SAGD) for the in-situ recovery of heavy oils and bitumens was reviewed and compared with the performance of alternative enhanced energy recovery technologies such as vapor extraction (VAPEX). The conference was attended by local and international participants in the petroleum sector, including managers, engineers, technologists, geologists, and other petroleum industry specialists. The conference featured 132 presentations addressing topics such as improved recovery of conventional oil and gas; heavy oil ...

2007-06-12

425

Potential for energy production and use from biogas in Brazil; Potencial de aproveitamento energetico do biogas no Brasil

The existence, in real-time, of transmission constraints, demand forecasting errors, generator failures, and other factors impose additional costs through the need to run more expensive generation. These costs can appear as a significant component of the wholesale price to demand served by electricity markets operated over transmission networks. In the England & Wales Pool these costs are passed through directly to supply companies. The Transmission System Operator ({open_quotes}TSO{close_quotes}) can exert significant influence on these costs through improved availability of transmission circuits and through appropriate investment, but has no incentive to do so. Since the inception of the Pool, these costs have increased in level and volatility, and have proved difficult to hedge. In response, St Clements Services were instrumental in assisting Pool members to develop an {open_quotes}Uplift Incentive Management Scheme{close_quotes} which has seen controllable ...

1996-03-01

426

Population exposure to power-frequency fields: concepts, components, and control

Biogas, produced from anaerobic digestion of organic matter in domestic, industrial and rural wastewaters and residuals, represent an alternative and renewable source of energy, with growing use worldwide. In Brazil, high population and its spatial concentration and expressive agricultural and agricultural-industrial production indicate a substantial potential of biogas production. The results presented in this work show a potential of biogas production of almost 2 billion cubic feet a day of CH{sub 4}. Viability of biogas production and use depends substantially on project scale. Generally, biogas projects are viable from landfills and domestic wastewater treatment for populations higher than 50,000 inhabitants and swine and dairy farms with at least 5,000 and 1,000 animals, respectively. Biogas is also competitive when compared to fossil fuels used in industry and transport. Despite incentive mechanisms for biogas production and use, like Clean Development Mechanism and renewable and ...

2009-12-15

427

Phase-out of leaded gasoline: a prescription for Lebanon

There are many sources of population exposures to power-frequency (50/60 Hz) electric and magnetic fields including household appliances and wiring, neighborhood distribution circuits, and high-voltage transmission lines. Bioeffects studies were unable to demonstrate that exposures to power-frequency fields can affect public health. Researcher have likewise been unable to show that the health effects of such exposures are negligible. State and federal regulatory agencies are, therefore, grappling with questions of whether and how to regulate the sitting or design of new extra high-voltage transmission lines so as to control the ground-level fields to which people are exposed. The purpose of this dissertation is to illuminate some of the exposure-related aspects of these question. A taxonomy of the relationship between field encounter and effect is developed to clarify the meaning of terms such as exposure and dose in the power-frequency context. The major inputs to ...

1986-01-01

428

Occupational health priorities for health standards: the current NIOSH approach.

Full text.Lead is a toxic heavy metal. Nevertheless, it has been mined and used for more than 800 years. Among the different contemporary sources of lead pollution, emissions from the combustion of leaded gasoline is of particular concern, as it can constitutes more than 90 percent of total lead emissions into the atmosphere in congested urban areas. Concentrations of lead in air and blood are strongly correlated with gasoline lead content and traffic volume. As a result of the increasing awareness about the dangers of lead to human health and the measures to manage urban air pollution, the use of leaded gasoline has been decreasing worldwide. In Lebanon, in the absence of policies to reduce the use of lead in gasoline or to favor the use of unleaded gasoline, leaded gasoline is the predominant grade. The objective of this research work is to analyze the current status of gasoline, and to assess the feasibility and prospect of such action. For this purpose, background information are ...

2000-11-23

429

Natural circulation cooling in US Pressurized Water Reactors

Government agencies responsible for protecting the public from the adverse effects of toxic chemicals must set priorities for research, regulatory action, protocol testing, and monitoring due to the vast number of toxic chemicals and the limited resources available to these agencies. The National Institute for Occupational Safety and Health (NIOSH) must set priorities for research on hazards encountered in the workplace. Priorities are also utilized by NIOSH in preparing criteria for recommended occupational standards which are forwarded to the Occupational Safety and Health Administration (OSHA), U.S. Department of Labor, for possible promulgation. For various reasons, including rapidly changing conditions in the American workplace, NIOSH has instituted a revised priorities program. In the future, NIOSH research and recommended standards activities will focus not only on individual chemicals, but also on industries, occupations, chemical classes, and general ...

1979-05-01

430

Market-based pricing of wholesale electric services

This document is a synthesis of data and analysis concerning natural circulation cooling in US Pressurized Water Reactors during off-normal operation and accident transients. Its objective is the integration of important research findings concerning PWR natural circulation phenomena into a single reference document. Sources of information include the Nuclear Regulatory Commission, reactor vendors, utility sponsored research groups, utilities, national laboratories, research reports, meeting papers, archival literature, and foreign sources. Three modes of natural circulation are discussed: single-phase, two-phase, and reflux/boiling condensation. General characteristics, analytical expressions, noncondensible gas effects, secondary effects, and nonuniform flow are described with regard to each of the natural circulation modes. Plant operational data, tests in scaled experimental facilities, and analysis with thermal hydraulic system codes have demonstrated the ...

431

Long-term storage of Greater-Than-Class C Low-Level Waste

Traditionally, the Federal Energy Regulatory Commission has implemented its statutory requirement that wholesale electric rates be just and reasonable by comparing a seller's proposed rates to its own cost of service. In the last four years, 40 requests for market-based prices have opened up an alternate path for just and reasonable rates. The common characteristic of these 40 requests is that the price is not tied directly to the seller's own costs but rather to market conditions. To date, the Commission has approved 28 of these requests and rejected eight. Four are pending. In this paper the authors assess what has happened, and describe the common standards that have been developed on a case-by-case basis in the last four years. In particular, they examine how these standards have been applied in cases involving affiliates of traditional utilities. Finally, they discuss some of the unresolved issues and possible implications of the new ...

1991-12-01

432

Limiting values of radionuclide intake and air concentration and dose conversion factors for inhalation, submersion, and ingestion: Federal guidance report No. 11

Under Federal law, the Department of Energy (DOE) is responsible for safe disposal of Greater-Than-Class C Low-Level Waste (GTCC LLW) generated by licenses of the Nuclear Regulatory commission (NRC) or Agreement States. Such waste must be disposed of in a facility licensed by the NRC. It is unlikely that licensed disposal of GTCC LLW will be available prior to the year 2010. Pending availability of disposal capacity, DOE is assessing the need for collective, long-term storage of GTCC LLW. Potential risks to public health and safety caused by long-term storage of GTCC LLW at the place of generation will be evaluated to determine if alternative facilities are warranted. If warranted, several options will be investigated to determine the preferred alternative for long-term storage. These options include modification of an existing DOE facility, development of a new DOE facility, or development of a facility by the private sector with or without DOE support. Reasonable ...

1990-01-01

433

Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc.

Radiation protection programs for workers are based, in the United States, on a hierarchy of limitations stemming from Federal guidance approved by the President. This guidance, which consists of principles, policies, and numerical primary guides, is used by Federal agencies as the basis for developing and implementing their own regulatory standards. The primary guides are usually expressed in terms of limiting doses to workers. The protection of workers against taking radioactive materials into the body, however, is accomplished largely through the use of regulations based on derived guides expressed in terms of quantities or concentrations of radionuclides. The values of these derived guides are chosen so as to assure that workers in work environments that conform to them are unlikely to receive radiation doses that exceed the primary guides. The purpose of the present report is to set forth derived guides that are consistent with current Federal radiation ...

1988-09-01

434

Licensing experiences of safety critical software systems in nuclear applications a case study

Endoreduplication represents a cell cycle variant during which multiple rounds of DNA replication occur without subsequent chromosome separation and cytokinesis, resulting into a cellular increase of the DNA content. Although the DNA ploidy level of cells is controlled by external stimuli such as light, currently limited knowledge is available on how environmental signals regulate the endoreduplication cycle at the molecular level. Previously, we have demonstrated that the conversion from the mitotic cell cycle into an endoreduplication cycle is mediated by the atypical E2F transcription factor DEL1 that operates as a repressor of endocycle onset. Here, we identified DEL1 as a transcriptional target of the classical E2Fb and E2Fc transcription factors that antagonistically control DEL1 transcript levels through competition for a single E2F cis-acting binding site. Correspondingly with the reported opposite effect of light on the E2Fb and E2Fc protein levels, the transcription of DEL1 ...

2011-09-01

435

Licensing experiences of safety critical software systems in nuclear applications a case study

This paper summarizes results of reviews on the safety, critical software performed during the licensing process for the new Wolsung units. Each of these CANDU-type nuclear power plants has two micro-computerized shutdown systems. The SDS No. 1 program is graphically programmed in such a manner that its development process does not essentially differ from the design process of the conventional analog counterpart. This approach is understandable even to a reviewer in the regulatory agency without additional training in software engineering. The confidence in the reliability of this system is strengthened by the reverse verification and increased by extensive testing such as the reliability test. Concerning SDS No. 2, the development process is significantly influenced by the {open_quotes}software cost reduction project{close_quotes} of the U.S. naval research laboratory, and is, as a whole, clear and well structured except for the modules related to the operation of ...

1997-12-01

436

LERF Assessment on the AOT changes for Kori 3 and 4 / Yonggwang 1 and 2

This paper summarizes results of reviews on the safety, critical software performed during the licensing process for the new Wolsung units. Each of these CANDU-type nuclear power plants has two micro-computerized shutdown systems. The SDS No. 1 program is graphically programmed in such a manner that its development process does not essentially differ from the design process of the conventional analog counterpart. This approach is understandable even to a reviewer in the regulatory agency without additional training in software engineering. The confidence in the reliability of this system is strengthened by the reverse verification and increased by extensive testing such as the reliability test. Concerning SDS No. 2, the development process is significantly influenced by the software cost reduction project of the U.S. naval research laboratory, and is, as a whole, clear and well structured except for the modules related to the operation of the computer itself. These ...

1997-06-01

437

Inventory of tritium concentration of waters in the Manche department; Inventaire des concentrations en tritium des eaux du Departement de La Manche

Allowed outage time (AOT), which is required by the technical specification of nuclear power plants (NPPs), has been determined on the basis of deterministic analysis or engineering judgment. AOT is defined as the time for which safety related components can remain inoperable before a plant state is changed. Recently, plants' operating experiences and probabilistic safety assessment (PSA) results show that the AOT could be optimized. Foreign NPPs licensees have changed their technical specifications including AOT using PSA techniques. In 1998, U.S. NRC issued the regulatory guides on risk informed decision-making and technical specification changes, and these are Reg. Guide 1.174, and 1.177. The US NRC accepted AOT extension proposals including the safety injection tank (SIT) and low pressure safety injection system (LPSI) for the ABB-CE designed plants. This paper discusses interim results of AOT changes of the SIT, LPSI, CSS (Containment Spray System) and EDG for ...

2007-05-10

438

Inventory determination of low and intermediate level radioactive waste of Paks Nuclear Power Plant origin

For the inventory of water tritium concentration in the Manche department, it is the complementarity that animated the work opened during year 2001. To answer to a commune sensitivity such water quality, particularly drinking water at tap, the A.C.R.O. laboratory brought its know how to make and its technical means in the area of tritium analysis and the general council brought its know how to make and its logistics means in matter of sanitary control. This collaboration has allowed to supply an indication on the tritium content of the distribution waters of thirty of the most important cities of the department. Then, it allowed to inform on the radiological situation (in relation with the tritium presence) of coast waters and principal rivers waters. More than 160 controls have been realised between the months of march 2001 and february 2002. Only the tritium under the shape of tritiated water has been measured. The measures have been made by liquid scintillation according to the ...

2007-07-01

439

Initiation of depleted uranium oxide and spent fuel testing for the spent fuel sabotage aerosol ratio programme

In the execution of disposal of low and intermediate level radioactive wastes, it is important to evaluate accurately the kind and quantity of each radionuclide in the wastes. For such an evaluation, correlation of non-gamma-emitting nuclides based on gamma-emitting nuclides is recommended and regarded as a partial method. This method necessitates a completion of a highly accurate and reliable nondestructive assay system of gamma-emitting nuclides for partical use. In 1992, in support of the new waste disposal program in Hungary, Paks NPP initiated a waste characterization program to determine the radiological properties of its rad wastes. A segmented gamma scanning system has been set up to measure the gamma-emitting nuclides in 2000 litre low level drums following in-drum compaction. In the framework of the program a radiochemical analysis sub-program was stated to determine the long-lived non-gamma emitting radionuclides, mainly those listed in US regulatory ...

440

Initiation of depleted uranium oxide and spent fuel testing for the spent fuel sabotage aerosol ratio programme

We provide a detailed overview of an on-going, multinational test programme that is developing aerosol data for some spent fuel sabotage scenarios on spent fuel transport and storage casks. Experiments are being performed to quantify the aerosolised materials plus volatilised fission products generated from actual spent fuel and surrogate material test rods, due to impact by a high-energy/density device. The programme participants in the United States plus Germany, France and the United Kingdom, part of the international Working Group for Sabotage Concerns of Transport and Storage Casks (WGSTSC) have strongly supported and coordinated this research programme. Sandia National Laboratories has the lead role for conducting this research programme; test programme support is provided by both the US Department of Energy and the US Nuclear Regulatory Commission. We provide a summary of the overall, multiphase test design and a description of all explosive containment and ...

2004-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

Initiation of depleted uranium oxide and spent fuel testing for the spent fuel sabotage aerosol ratio program.

We provide a detailed overview of an on-going, multinational test programme that is developing aerosol data for some spent fuel sabotage scenarios on spent fuel transport and storage casks. Experiments are being performed to quantify the aerosolised materials plus volatilised fission products generated from actual spent fuel and surrogate material test rods, due to impact by a high-energy/density device. The programme participants in the United States plus Germany, France and the United Kingdom, part of the international Working Group for Sabotage Concerns of Transport and Storage Casks (WGSTSC) have strongly supported and coordinated this research programme. Sandia National Laboratories has the lead role for conducting this research programme; test programme support is provided by both the US Department of Energy and the US Nuclear Regulatory Commission. We provide a summary of the overall, multiphase test design and a description of all explosive containment and ...

442

Initiation of depleted uranium oxide and spent fuel testing for the spent fuel sabotage aerosol ratio program

The authors provide a detailed overview of an on-going, multinational test program that is developing aerosol data for some spent fuel sabotage scenarios on spent fuel transport and storage casks. Experiments are being performed to quantify the aerosolized materials plus volatilized fission products generated from actual spent fuel and surrogate material test rods, due to impact by a high-energy-density device. The program participants in the United States plus Germany, France and the United Kingdom, part of the international Working Group for Sabotage Concerns of Transport and Storage Casks (WGSTSC) have strongly supported and coordinated this research program. Sandia National Laboratories has the lead role for conducting this research program; test program support is provided by both the US Department of Energy and the US Nuclear Regulatory Commission. The authors provide a summary of the overall, multiphase test design and a description of all explosive ...

2004-08-01

443

In situ remediation of uranium contaminated groundwater

The authors provide a detailed overview of an on-going, multinational test program that is developing aerosol data for some spent fuel sabotage scenarios on spent fuel transport and storage casks. Experiments are being performed to quantify the aerosolized materials plus volatilized fission products generated from actual spent fuel and surrogate material test rods, due to impact by a high-energy-density device. The program participants in the United States plus Germany, France and the United Kingdom, part of the international Working Group for Sabotage Concerns of Transport and Storage Casks (WGSTSC) have strongly supported and coordinated this research program. Sandia National Laboratories has the lead role for conducting this research program; test program support is provided by both the US Department of Energy and the US Nuclear Regulatory Commission. The authors provide a summary of the overall, multiphase test design and a description of all explosive ...

444

Identification of three related human GRO genes encoding cytokine functions

In an effort to develop cost-efficient techniques for remediating uranium contaminated groundwater at DOE Uranium Mill Tailing Remedial Action (UMTRA) sites nationwide, Sandia National Laboratories (SNL) deployed a pilot scale research project at an UMTRA site in Durango, CO. Implementation included design, construction, and subsequent monitoring of an in situ passive reactive barrier to remove Uranium from the tailings pile effluent. A reactive subsurface barrier is produced by emplacing a reactant material (in this experiment various forms of metallic iron) in the flow path of the contaminated groundwater. Conceptually the iron media reduces and/or adsorbs uranium in situ to acceptable regulatory levels. In addition, other metals such as Se, Mo, and As have been removed by the reductive/adsorptive process. The primary objective of the experiment was to eliminate the need for surface treatment of tailing pile effluent. Experimental design, and laboratory and field ...

1997-02-01

445

Hydrogen control using igniters and pars during severe accidents

The product of the human GRO gene is a cytokine with inflammatory and growth-regulatory properties; GRO is also called MGSA for melanoma growth-stimulatory activity. The authors have identified two additional genes, GRO#beta# and GRO#gamma#, that share 90% and 86% identity at the deduced amino acid level with the original GRO#alpha# isolate. One amino acid substitution of proline in GRO#alpha# by leucine in GRO#beta# and GRO#gamma# leads to a large predicted change in protein conformation. Significant differences also exist in the 3' untranslated region, including different numbers of ATTTA repeats associated with mRNA instability. A 122-base-pair region in the 3' region is conserved among the three GRO genes, and a part of it is also conserved in the Chinese hamster genome, suggesting a role in regulation. DNA hybridization with oligonucleotide probes and partial sequence analysis of the genomic clones confirm that the three forms are derived from related but ...

446

Hsp22 (HspB8/H11) knockdown induces sam68 expression and stimulates proliferation of glioblastoma cells

Full text of publication follows: The hydrogen mitigation system of 20 igniters and 6 PARs is installed to control the hydrogen in the containment during severe accidents and design basis accidents, respectively, in Shin-Wolsung 1 and 2 nuclear power plants. The igniters are primarily installed at the hydrogen source locations, and the PARs are installed in the open spaces. The PARs will maintain the hydrogen concentration within the containment atmosphere below the limit of 4 v/o in accordance with Regulatory Guide 1.7 during design basis accidents. The igniters will maintain the hydrogen concentration within the containment atmosphere below the limit of 10 v/o in accordance with 10CFR50.34(f) during severe accidents. In addition, the PARs can be used as a supplementary means to control the hydrogen concentration during severe accidents because of their inherent passive characteristics. This paper shows the three dimensional results using the GOTHIC computer code ...

2005-12-11

447

British Library Electronic Table of Contents (United Kingdom)

Abstract Sam68 (Src-associated protein in mitosis 68-kDa) is a multifunctional protein, known to govern cellular signal transduction, transcription, RNA metabolism, proliferation, apoptosis, and HIV-1 replication. Although intrinsic mechanisms that modulate Sam68 function are beginning to emerge, the regulatory events contributing to its expression remain elusive. We previously reported that heat shock protein-22 (Hsp22) antagonizes Sam68 function in rev-response element (RRE)-mediated gene expression. We now demonstrate that Sam68 levels correlate inversely with Hsp22 in a variety of cells, including U87, Jurkat, 293T, and U-937. In U87 glioblastoma cells, which contained high levels of Hsp22 than other cell lines tested, Hsp22 knockdown dramatically increased both Sam68 mRNA and protein,...

2011-01-01

448

How does one develop the right quality assurance program for waste management projects?

Government response to public consultation. Offshore natural gas storage and liquefied natural gas import facilities

The quality assurance requirements in use today for radioactive waste facilities, geologic repositories and hazardous waste projects were developed initially for the nuclear power plant industry, and their intent is being applied by regulations and guidance documents to radioactive and hazardous waste programs. The wording of the NRC quality assurance requirements in Appendix B of 10CFR50, the related guidance documents and the industry's ANSI/ASME NQA-1 were developed over a period of several years to address quality assurance for the design and construction of the complex and interactive systems to produce electrical power using nuclear fuel. Now, those same documents are the basis for the quality assurance requirements and guidance for waste management facilities and repositories. The intent of Appendix B of 10CFR50 and NQA-1 can easily be applied to waste projects, providing one understands and uses the intent of the requirements. This paper describes the intent of existing QA ...

1988-10-03

449

Free release waste characterisation during the decommissioning of windscale Pile 2 Chimney

As its indigenous gas supplies decline, the UK will need to import more gas. In November 2006, the Department of Trade and Industry issued a consultation on revising the consent regime for offshore gas storage and offshore liquefied natural gas unloading. A total of 27 responses had been received by the closing date of 16 February 2007 from a variety of interest parties including developers and their representative organisations, consultants, environmental organisations, maritime organisations, heritage organisations and other public bodies. This report presents the Government's response to the views expressed by these respondents. The majority of respondents supported the Government's proposals to put in place new legislation to permit offshore gas storage activities. Many believed new legislation was necessary to provide the legal certainty necessary ro encourage offshore development and investment in such developments. Non-regulatory solutions ...

2007-05-15

450

Framework for managing wastes from oil and gas exploration and production (E&P) sites.

The decommissioning of windscale Pile 2 Chimney resulted in the removal of one of most historically significant and prominent features of the Sellafield site. The project was the first large scale concrete ''free release'' operation to be undertaken on the Sellafield nuclear site, producing 4500 tons of concrete of which 3000 tons was demonstrated to be ''free release''. The paper describes the radiometric techniques employed in the characterisation and segregation of the concrete into low level waste (LLW), very low level waste (VLLW) and free release categories. It examines the robust solutions that were developed to meet the technical and regulatory challenges of the project, which included the definition of free release, the selection of averaging volumes, the testing and validation of the monitoring systems employed for ton quantities of concrete and the identification and removal of small numbers of fuel particles from the free release waste stream. As a ...

2002-09-22

451

Final Report of the 2nd Ex-Vessel Neutron Dosimetry Installation And Evaluations for Kori Unit 3 Reactor Pressure Vessel

Oil and gas companies operate in many countries around the world. Their exploration and production (E&P) operations generate many kinds of waste that must be carefully and appropriately managed. Some of these wastes are inherently part of the E&P process; examples are drilling wastes and produced water. Other wastes are generic industrial wastes that are not unique to E&P activities, such as painting wastes and scrap metal. Still other wastes are associated with the presence of workers at the site; these include trash, food waste, and laundry wash water. In some host countries, mature environmental regulatory programs are in place that provide for various waste management options on the basis of the characteristics of the wastes and the environmental settings of the sites. In other countries, the waste management requirements and authorized options are stringent, even though the infrastructure to meet the requirements may not be available ...

2007-09-15

452

Facility Effluent Monitoring Plan for Pacific Northwest National Laboratory Balance-of-Plant Facilities

This report describes a neutron fluence assessment performed for the Kori Unit 3 pressure vessel beltline region based on the guidance specified in Regulatory Guide 1.190. In this assessment, maximum fast neutron exposures expressed in terms of fast neutron fluence (E>1 MeV) and iron atom displacements (dpa) were established for the beltline region of the pressure vessel. After Cycle 16 of reactor operation, 2nd Ex-Vessel Neutron Dosimetry Program was instituted at Kori Unit 3 to provide continuous monitoring of the beltline region of the reactor vessel. The use of the Ex-Vessel Neutron Dosimetry Program coupled with available surveillance capsule measurements provides a plant specific data base that enables the evaluation of the vessel exposure and the uncertainty associated with that exposure over the service life of the unit. Ex-Vessel Neutron Dosimetry has been evaluated at the conclusion of Cycle 17

2006-06-13

453

FY 1987 current fiscal year work plan

The Pacific Northwest National Laboratory (PNNL) operates a number of research and development (R and D) facilities for the Department of Energy on the Hanford Site. According to DOE Order 5400.1, a Facility Effluent Monitoring Plan is required for each site, facility, or process that uses, generates, releases, or manages significant pollutants or hazardous materials. Three of the R and D facilities: the 325, 331, and 3720 Buildings, are considered major emission points for radionuclide air sampling and thus individual Facility Effluent Monitoring Plans (FEMPs) have been developed for them. Because no definition of ''significant'' is provided in DOE Order 5400.1 or the accompanying regulatory guide DOE/EH-0173T, this FEMP was developed to describe monitoring requirements in the DOE-owned, PNNL-operated facilities that do not have individual FEMPs. The remainder of the DOE-owned, PNNL-operated facilities are referred to as ...

1999-04-02

454

FFTF [Fast Flux Test Facility] Integrated Leak Rate Test Computer System

This Current Year Work Plan presents a detailed description of the activities to be performed by the Joint Integration Office during FY87. It breaks down the activities into two major work areas: Program Management and Program Analysis. Program Management is performed by the JIO by providing technical planning and guidance for the development of advanced TRU waste management capabilities. This includes equipment/facility design, engineering, construction, and operations. These functions are integrated to allow transition from interim storage to final disposition. JIO tasks include program requirements identification, long-range technical planning, budget development, program planning document preparation, task guidance, task monitoring, information gathering and task reporting to DOE, interfacing with other agencies and DOE lead programs, integrating public involvement with program efforts, and preparation of program status reports for DOE. Program Analysis is performed by the JIO to ...

1986-12-01

455

Extremely low frequency electric and magnetic fields and cancer: A literature review

The Fast Flux Test Facility (FFTF) is a liquid-metal-cooled test reactor located on the Hanford Site. The FFTF is the only reactor of this type designed and operated with the intent of meeting the licensing requirements of the Nuclear Regulatory Commission (NRC). Unique characteristics of the FFTF that present special challenges related to leak rate testing include thin wall containment vessel construction, cover gas systems that penetrate containment, and a low-pressure design basis accident. The successful completion in 1986 of the third FFTF Integrated Leak Rate Test (ILRT) five days ahead of schedule and 10% under budget was a major achievement for the Westinghouse Hanford Company. The success of this operational safety test was due in large part to a special local area network (LAN) of three IBM PC/XT computers that monitored the sensor data, calculated the containment vessel leak rate, and displayed test results. The multiple computer configuration allowed ...

456

Experiences with applications of PSA results for optimization/revision of technical specifications for operation of nuclear power plants

Epidemiologic studies suggest a weak link between occupational or residential exposure to extremely low frequency electromagnetic fields and cancer, especially tumors of the central nervous and hematopoietic systems. This report discusses these studies with reference to basic research on ELF EMF bioeffects relevant to cancer-promoting mechanisms. Many of the studies suggest a possible interaction of ELF EMF with the immune system, endocrine system, or growth-regulatory signals and morphogenic movements that involve calcium flux through cell membranes. Many bioeffects have been reported only with certain specific combinations of frequency, amplitude, and orientation of the EMF signal with respect to the geomagnetic field. The possibility of signal-specific effects raises a complication in dosimetry for both epidemiologic and experimental studies since ELF EMF effects may not be directly related to field strength. The report concludes with a discussion of design ...

1989-12-01

457

Evaluation of red mud as pozzolanic material in replacement of cement for production of mortars; Avaliacao da lama vermelha como material pozolanico em substituicao ao cimento para producao de argamassas

Over the past few years, NPCIL has performed comprehensive Level-1 Probabilistic Safety Assessment (PSA) for a 220 MWe Pressurised Heavy Water Reactor (PHWR) at Kakrapar Atomic Power Station (KAPS) and for the first 540 MWe PHWR at Tarapur Atomic Power Project (TAPP- 3 and 4). The major objective of these PSAs was to present an integrated picture of the safety of the plant to identify and understand key plant vulnerabilities. As a result of the availability of these PSAs, there is a desire to use them to operate the plants in the most efficient manner practicable. In recent years, the operation of Indian Nuclear Power Plants has been characterized by improved availability/capacity factors and reduced forced outages. Frequency of planned outages is also being reduced. In order to achieve this, the PSAs are now being used as an engineering tool for optimization of Technical Specifications with regard to Allowed Outage Time (AOT) and Surveillance Test Intervals (STIs). USNRC ...

2005-12-01

458

Evaluation of red mud as pozzolanic material in replacement of cement for production of mortars

Red mud is a by-product of the alkaline extraction of aluminum from the bauxite and represents a renewed environmental problem due the significant annual throughput by the plants. In the present work, the pozzolanic properties of Brazilian red mud fired at 600, 700, 800 and 900 deg C were investigated by monitoring lime consumption using DTA analysis and Brazilian standard methodology NBR 5772 (1992). Products and kinetics of hydration were determined in cement pastes produced with 5 and 15% red mud using x-ray diffraction and DTA analysis. Compressive strength and capillary absorption tests were realized on mortars constituted by 5, 10 and 15% red mud in replacement of cement. When calcined at 600 deg C, the red mud develops good pozzolanic properties, and the compressive strength of mortars produced with this waste meet values in accordance with regulatory standard. These results shown than red mud can be used, in partial replacement of cement, as new ...

2010-07-01

459

Evaluation of actinide biosorption by microorganisms

Red mud is a by-product of the alkaline extraction of aluminum from the bauxite and represents a renewed environmental problem due the significant annual throughput by the plants. In the present work, the pozzolanic properties of Brazilian red mud fired at 600, 700, 800 and 900 deg C were investigated by monitoring lime consumption using DTA analysis and Brazilian standard methodology NBR 5772 (1992). Products and kinetics of hydration were determined in cement pastes produced with 5 and 15% red mud using x-ray diffraction and DTA analysis. Compressive strength and capillary absorption tests were realized on mortars constituted by 5, 10 and 15% red mud in replacement of cement. When calcined at 600 deg C, the red mud develops good pozzolanic properties, and the compressive strength of mortars produced with this waste meet values in accordance with regulatory standard. These results shown than red mud can be used, in partial replacement of cement, as new ...

2010-11-21

460

Establishment of an Undergraduate Research and Training Program in Radiochemistry at Florida Memorial University, a Historically Black College or University (HBCU)

Conventional methods for removing metals from aqueous solutions include chemical precipitation, chemical oxidation or reduction, ion exchange, reverse osmosis, electrochemical treatment and evaporation. The removal of radionuclides from aqueous waste streams has largely relied on ion exchange methods which can be prohibitively costly given increasingly stringent regulatory effluent limits. The use of microbial cells as biosorbants for heavy metals offers a potential alternative to existing methods for decontamination or recovery of heavy metals from a variety of industrial waste streams and contaminated ground waters. The toxicity and the extreme and variable conditions present in many radionuclide containing waste streams may preclude the use of living microorganisms and favor the use of non-living biomass for the removal of actinides from these waste streams. In the work presented here, we have examined the biosorption of uranium by non-living, non-metabolizing ...

1996-06-01

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461

Epigenomic disruption: the effects of early developmental exposures.

With the passing of the Energy Policy Act of 2005, the United States is experiencing for the first time in over two decades, what some refer to as the 'Nuclear Renaissance'. The US Nuclear Regulatory Commission (NRC) recognizes this surge in application submissions and is committed to reviewing these applications in a timely manner to support the country's growing energy demands. Notwithstanding these facts, it is understood that the nuclear industry requires appropriately trained and educated personnel to support the growing needs of the nuclear industry and the US NRC. Equally important is the need to educate the next generation of students in nuclear non-proliferation, nuclear forensics and various aspects of homeland security for the national laboratories and the Department of Defense. From mechanical engineers educated and experienced in materials, thermal/fluid dynamics, and component failure analysis, to physicists using advanced ...

2009-08-19

462

Environmental monitoring at Kahe Point, Oahu, Hawaii for OTEC pilot-plant development

Through DNA methylation, histone modifications, and small regulatory RNAs the epigenome systematically controls gene expression during development, both in utero and throughout life. The epigenome is also a very reactive system; its labile nature allows it to sense and respond to environmental perturbations to ensure survival during fetal growth. This pliability can lead to aberrant epigenetic modifications that persist into later life and induce numerous disease states. Endocrine-disrupting compounds (EDCs) are ubiquitous chemicals that interfere with growth and development. Several EDCs also interfere with epigenetic programming. The investigation of the epigenotoxic effects of bisphenol A (BPA), an EDC used in the production of plastics and resins, has further raised concern over the impact of EDCs on the epigenome. Using the Agouti viable yellow (A(vy)) mouse model, dietary BPA exposure was shown to hypomethylate both the A(vy) and the Cabp(IAP) metastable ...

2010-10-01

463

Energy report Frankfurt am Main 1992; Stadt Frankfurt am Main. Energiebericht 1992

Two 40 MWe Ocean Thermal Energy Conversion (OTEC) Pilot Plant programs are in the initial phase of development near Kahe Point, Oahu, Hawaii. The two options being examined are: (1) a shelf-seated artificial island, connected via a causeway to Oahu, using stainless steel heat exchangers, with the thermal resource enhanced by effluent from a near-by power plant, ammonia working fluid and biocide (chlorine) cleaning; and (2) a shelf mount tower 1 mile off shore using submerged aluminum heat exchangers, R-22 working fluid, and slurry cleaning with biocide (chlorine) backup. Environmental Technical Requirements are described including: siting criteria; environmental design, and operational criteria; thermal resource evaluation and variability; physical, chemical, and biological data requirements; and regulatory requirements. Due to siting, design, and operational differences the proposed two pilot plant options have individual environmental monitoring criteria and ...

1982-08-01

464

Effectiveness of storage practices in mitigating aging degradation during reactor layup

By joining the `climate association of European cities`, Frankfurt has agreed to reduce its CO{sub 2}-emissions by 50% by the year 2010. The so-called `climate offense 1991` was the first regulatory paper to be set up by a community to reach this goal over a long term. This report now represents the present level of the project. Main points are the development of houses with low entropy, the retrofitting of heating systems, water saving measures and energy management. (BWI) [Deutsch] Durch den Beitritt zum `Klima-Buendnis der Europaeischen Staedte` hat sich die Stadt Frankfurt/M. verpflichtet, die CO{sub 2}-Emissionen bis zum Jahr 2010 um 50% zu senken. Mit der sog. `Klimaoffensive 1991` wurde dann erstmals von einer Kommune in Deutschland ein detailliertes Regelwerk aufgestellt, um dieses Ziel langfristig erreichen zu koennen. Der vorliegende Bericht stellt den aktuellen Stand des Projektes dar. Kernpunkte sind die Entwicklung von Niedrigentropiehaeusern, die ...

1993-12-31

465

Economic evaluation of oil shale and tar sands resources located in the state of Utah. Phase I: final report

One of the issues identified in the US Nuclear Regulatory Commission`s Nuclear Plant Aging Research program plan is the need to understand the state of ``mothballed`` or other out-of-service equipment to ensure subsequent safe operation. Programs for proper storage and preservation of materials and components are required by NRC regulations (10 CFR 50, Appendix B). However, materials and components have been seriously degraded due to improper storage, protection, or layup, at facilities under construction as well as those with operating licenses. Pacific Northwest Laboratory has evaluated management of aging for unstarted or mothballed nuclear power plants. The investigations revealed that no uniform guidance in the industry addresses reactor layup. In each case investigated, layup was not initiated in a timely manner, primarily because of schedule uncertainty. Hence, it is reasonable to assume that this delay resulted in accelerated aging of some ...

1995-09-01

466

Dose assessment and behavior of tritium in environmental samples around Wolsong nuclear power plant.

Managing public lands for maximum social benefit is becoming an increasingly complex task. The growing need for domestically produced mineral raw materials and energy, and the conflicting interests over the use of public lands, have added new dimensions to the management issues. This report covers the first phase of a long-term program initiated by the Division of State Lands to improve their capability to evaluate the tar-sand and oil-shale resources in Utah. The scope of this phase of the study was limited to examination and analysis of existing information and to development models for data processing and resource evaluation. The study was effective in identifying problem areas and demonstrating the potential value of the proposed systems for management of state lands. It is anticipated that effective evaluation of the oil-shale and tar-sand resources in Utah, supported by readily accessible physical data, will lead to improved management both in policy and in legislation so that a ...

1981-03-01

467

Development of Risk Management Technology/Development of Risk-Informed Application Technology

For the estimation of the dispersion trend of tritium discharged from the Wolsung nuclear power plant, the present level of tritium in environmental samples in the vicinity of the Wolsong site has been studied. On the basis of tritium concentrations in environmental samples, the effective dose due to tritium has been estimated for an individual and population within a 16 km radius from the Wolsong site. The annual effective dose of tritium to an inhabitant around the Wolsong site ranged from 0.15 microSv y-1 to 1.3 microSv y-1. The dose level was negligible and much lower than some applicable standards, i.e. the limit on exposure from nuclear fuel cycle to the general public as recommended by ICRP (1 mSv y-1) or US EPA's limit (0.25 mSv y-1). The collective dose to the total population within a 16 km radius from the site, 1.2 x 10(-2) man.Sv y-1 was much lower than 1 man.Sv y-1, an applicable criterion for the so-called "exemption" of radiation sources and practices from ...

1999-04-01

468

Detection of concealed mercury with thermal neutrons

This project aims at developing risk-informed application technologies to enhance the safety and economy of nuclear power plant altogether. For this, the Integrated Level 1 and 2 PSA model is developed. In addition, the fire and internal flooding PSA models are improved according to the PSA standard of U.S.A. To solve the issues of domestic PSA model, the best-estimate thermal hydraulic analyses are preformed for the ATWS and LSSB. In order to reduce the uncertainty of PSA, several new PSA technologies are developed: (1) more exact quantification of large fault tree, (2) importance measure including the effects of external PSA. As feasibility studies of Option 2 and 3, the class of 6 systems' SSC are re-classified based on the risk information and the sensitivity analyses is performed for the EDG starting time, respectively. It is also improved that the methodology to identify the vital area of NPP. The research results of this project can be used in the ...

2007-06-15

469

Departure from ICRP-60 in Canadian radiation protection regulations

In the United States today, governments at all levels and the citizenry are paying increasing attention to the effects, both real and hypothetical, of industrial activity on the environment. Responsible modem industries, reflecting this heightened public and regulatory awareness, are either substituting benign materials for hazardous ones, or using hazardous materials only under carefully controlled conditions. In addition, present-day environmental consciousness dictates that we deal responsibly with legacy wastes. The decontamination and decommissioning (D&D) of facilities at which mercury was used or processed presents a variety of challenges. Elemental mercury is a liquid at room temperature and readily evaporates in air. In large mercury-laden buildings, droplets may evaporate from one area only to recondense in other cooler areas. The rate of evaporation is a function of humidity and temperature; consequently, different parts of a building may be sources ...

1994-08-18

470

Critical review of studies on atmospheric dispersion in coastal regions

The Atomic Energy Control Board (AECB), Canada's nuclear regulatory authority, is preparing new regulations based on ICRP-60. The proposed regulations have some features which are different from ICRP-60, e.g., the limit for pregnant workers was set at a higher level than that proposed in ICRP-60. The AECB, through its consultative process, received many responses from female staff in nuclear medicine. The concern was that it would be very difficult to prove compliance with such low doses, particularly for internal doses. There was an additional concern that hospital administrators would respond to the reduction of the current pregnant worker limit from 10 mSv to the ICRP-60 recommended value of 2 mSv by discriminating against hiring women. A new proposal for the dose limit for pregnant workers has been made which will limit the dose to the mother by means of a combining formula that will take both external and internal doses into account. (author).

471

Control of population dose equivalent from naturally occurring radionuclides in building materials

This study effort was required as a preliminary step prior to initiation of field measurements of atmospheric dispersion in coastal regions. The Nuclear Regulatory Commission (NRC) is in the process of planning an extensive field measurement program to generate data which will serve as improved data bases for licensing decisions, confirmation of regulations, standards, and guides, and for site characterizations. The study being reported here is an effort directed to obtaining as much information as is possible from existing studies that is relevant toward NRC's objectives. For this study, reports covering research and meteorological measurements conducted for industrial purposes, utility needs, military objectives, and academic studies were obtained and critically reviewed in light of NRC's current data needs. This report provides an interpretation of the extent of existing usable information, an indication of the potential for tailoring existing ...

1982-09-01

472

Compendium of federal and state radioactive materials transportation laws and regulations: Transportation Legislative Database (TLDB)

Naturally occurring radionuclides in building materials are a source of external and interal radiation exposure to essentially the entire US population. Although detailed data are not available, estimates are that the average contribution from such sources to the external dose equilvaent rate in brick and masonry houses is about 5 to 10 mrem/year. For critical population groups, values reported in the literature for the contribution from such sources range up to a hundred mrem/year or more. Dose equivalent rates to the lungs are even higher and, for abnormal situations, it would appear that control measures, either on a voluntary or mandatory (legislative) basis should be considered. Such measures include: (1) material substitution; (2) improved manufacturing standards; (3) changes in basic building designs; (4) application of surface sealants; and (5) increased ventilation accompanied by processes for the adsorption and/or filtration of airborne radionuclides. Analyses show that ...

473

Commercial acceptability of solid polymer fuel cell systems in the role of combined heat and power packages

The Transportation Legislative Database (TLDB) is an on-line information service containing detailed information on legislation and regulations regarding the transportation of radioactive materials in the United States. The system is dedicated to serving the legislative and regulatory information needs of the US Department of Energy and other federal agencies; state, tribal, and local governments; the hazardous materials transportation industry; and interested members of the general public. In addition to the on-line information service, quarterly and annual Legal Developments Reports are produced using information from the TLDB. These reports summarize important changes in federal and state legislation, regulations, administrative agency rulings, and judicial decisions over the reporting period. Information on significant legal developments at the tribal and local levels is also included on an as-available basis. Battelle's Office of Transportation Systems and ...

1989-01-01

474

Columbia River Coordinated Information System (CIS); Phase II Cooperative Agreement, 1992 Technical Report.

This report aims to address the potential for solid polymer fuel cell (SPFC) systems to be successfully exploited in the combined heat and power (CHP) market. A number of market studies have been undertaken to look at the size and future potential for this CHP market as well as such issues as market forces and geographical locations. This study focuses on a different aspect, that of the technical and commercial requirement together with the development needs. In order to understand how an SPFC system will have to perform, it is first necessary to examine the criteria used to judge the commercial merits of a particular CHP scheme. Issues that must be addressed include: the investment criteria - time to pay back the investment or rate of return on the investment; the influence of external factors such as electricity cost tariffs, fuel price and regulatory requirements; the cost and performance of existing technology; and the influence of the energy demand profile of ...

1998-09-01

475

Challenges in environmental monitoring and reporting

Anadromous salmon in the Columbia River Basin are presently far below historic level of production, due to the impacts of development in the basin. To halt the downward trend in production and ultimately increase returns, the Northwest Power Planning Council developed the Columbia River Basin Fish and Wildlife Program. The Program outlines a coordinated plan for restoring anadromous salmonid runs to the basin. The goals and objectives outlined in the Program require addressing a complex set of problems that encompass a broad range of social, political, economic and biological issues. Resolution of these problems will require the efforts of a number of federal, state, and tribal agencies that have regulatory authority over activities that either directly or indirectly affect anadromous salmonids in the basin. Resource managers have realized the need for coordination in these efforts. The Coordinated Information System is designed to share information critical to ...

1993-05-01

476

Cell volume regulation in hemoglobin CC and AA erythrocytes

The Canadian Association of Petroleum Producers (CAPP) represents about 170 crude oil and natural gas exploration, development and production companies in regulatory hearings and legal proceedings. Its principal role is to enhance the economic well-being and sustainability of the Canadian upstream petroleum industry. This presentation explores the role that information technology (IT) plays in knowledge and information management and how this role relates to meeting Canada`s target for greenhouse gas emissions reductions set by the Kyoto Protocol. Actions such as the Voluntary Challenge Registry (VCR) and emissions reductions trading are re-visited and the information requirements associated with these actions are highlighted. It is shown that among others, emissions databases between jurisdictions (provincial, national, international) have to be integrated, reduction claims must be tracked, verified and cross-referenced to eliminate double counting, comprehensive ...

1998-12-31

477

CFD Application to the Regulatory Assessment of FAC-Caused CANDU Feeder Pipe Wall Thinning Issue

Swelling hemoglobin CC erythrocytes stimulates a ouabain-insensitive K flux that restores original cell volume. Studies were performed with the K analog, "8"6Rb. This volume regulatory pathway was characterized for its anion dependence, sensitivity to loop diuretics, and requirement for Na. The swelling-induced K flux was eliminated if intracellular chloride was replaced by nitrate and both swelling-activated K influx and efflux were partially inhibited by 1 mM furosemide or bumetanide. K influx in swollen hemoglobin CC cells was not diminished when Na in the incubation medium was replaced with choline, indicating Na independence of the swelling-induced flux. Identical experiments with hemoglobin AA cells also demonstrated a swelling-induced increase in K flux, but the magnitude and duration of this increase were considerably less than that seen with hemoglobin CC cells. The increased K flux in hemoglobin AA cells was likewise sensitive to anion replacement and to ...

478

CFD Application to the Regulatory Assessment of FAC-Caused CANDU Feeder Pipe Wall Thinning Issue

From the results of the In-Service Inspection (ISI) measuring the wall thickness of outlet (hot-leg side) feeder pipes performed at two Canadian nuclear power plants, Point Lepreau and Gentilly-2 in 1995 and 1996, respectively, the wall thinning degradation of feeder pipes at the bend part was found to be much more severe than expected. It has been well known that such wall thinning of feeder pipes is caused by the flow accelerated corrosion (FAC) which is one of the mechanical-chemical degradation mechanisms affecting the integrity of piping systems. For the Wolsung unit 1, the wall thickness measurements have been performed during every overhaul period since 1996. The wall thinning rates at the bends of outlet feeder pipes were assessed to exceed the design value. However, for the Wolsung units 2, 3 and 4, the wall thinning rates of all the outlet feeder pipes were assessed not to exceed it. The reason is because the content of Cr in the material of feeder pipes of Wolsung units 2, 3 ...

2007-07-01

479

CANDU 9 - the CANDU product to meet customer and regulator requirements now and in the future

From the results of the In-Service Inspection (ISI) measuring the wall thickness of outlet (hot-leg side) feeder pipes performed at two Canadian nuclear power plants, Point Lepreau and Gentilly-2 in 1995 and 1996, respectively, the wall thinning degradation of feeder pipes at the bend part was found to be much more severe than expected. It has been well known that such wall thinning of feeder pipes is caused by the flow accelerated corrosion (FAC) which is one of the mechanical-chemical degradation mechanisms affecting the integrity of piping systems. For the Wolsung unit 1, the wall thickness measurements have been performed during every overhaul period since 1996. The wall thinning rates at the bends of outlet feeder pipes were assessed to exceed the design value. However, for the Wolsung units 2, 3 and 4, the wall thinning rates of all the outlet feeder pipes were assessed not to exceed it. The reason is because the content of Cr in the material of feeder pipes of Wolsung units 2, 3 ...

2007-05-10

480

CANDU 9 - the CANDU product to meet customer and regulator requirements now and in the future

CANDU reactors developed under Canadian licensing regulations that placed the primary responsibility for safety on the licensee. The Atomic Energy Control Board (AECB), Canada's nuclear regulatory agency, state in their regulations what is expected in terms of safety performance so that designers are free to propose the best means of meeting this performance. This goal-oriented approach, besides encouraging innovation, allowed CANDU to be licensed in other jurisdictions. The latest design - the large, single unit, CANDU 9 - explicitly incorporates licensability in Canada through a formal AECB review of the design; lessons learned from licensing CANDU 6 in Asian countries, particularly with Wolsong 2, 3 and 4 in Korea, and more recently with Qinshan in China; utility requirements for modem evolutionary plants; and emerging international standards for safety, sponsored or issued by the IAEA. By combining the assurance of acceptability in Canada with ...

1998-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

481

Biological effects of low level exposures to chemicals and radiation

CANDU reactors developed under Canadian licensing regulations that placed the primary responsibility for safety on the licensee. The Atomic Energy Control Board (AECB), Canada's nuclear regulatory agency, state in their regulations what is expected in terms of safety performance so that designers are free to propose the best means of meeting this performance. This goal-oriented approach, besides encouraging innovation, allowed CANDU to be licensed in other jurisdictions. The latest design - the large, single unit, CANDU 9 - explicitly incorporates licensability in Canada through a formal AECB review of the design; lessons learned from licensing CANDU 6 in Asian countries, particularly with Wolsong 2, 3 and 4 in Korea, and more recently with Qinshan in China; utility requirements for modem evolutionary plants; and emerging international standards for safety, sponsored or issued by the IAEA. By combining the assurance of acceptability in Canada with compliance with ...

1998-05-03

482

Behavioral Economics and Regulatory Analysis.

In May 1990 a group of scientists representing several federal agencies, the International Society of Regulatory Toxicology and Pharmacology, the private sector, and academia met to develop a strategy to encourage the study of the biological effects of low level exposures (BELLE) to chemical agents and radioactivity. A workshop was held in 1991 with seven invited speakers focusing on the toxicological implications of biological adaptations. The selection of topics and speakers was designed to consider critically the concept of hormesis, not only in a broad, conceptual manner, but also at the molecular and biochemical levels. These presentations offered a complementary perspective on the diverse range of molecular mechanisms that can become activated at low levels of toxicant exposure. In addition to chemical toxicology research, an overview of current research on 'Effects of low-dose radiation on the immune response' was presented as well as 'Cellular adaptation as ...

483

Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target.

Behavioral economics has captured the interest of scholars and the general public by demonstrating ways in which individuals make decisions that appear irrational. While increasing attention is being focused on the implications of this research for the design of risk-reducing policies, less attention has been paid to how it affects the economic valuation of policy consequences. This article considers the latter issue, reviewing the behavioral economics literature and discussing its implications for the conduct of benefit-cost analysis, particularly in the context of environmental, health, and safety regulations. We explore three concerns: using estimates of willingness to pay or willingness to accept compensation for valuation, considering the psychological aspects of risk when valuing mortality-risk reductions, and discounting future consequences. In each case, we take the perspective that analysts should avoid making judgments about whether values are "rational" or "irrational." ...

2011-08-13

484

Analysis of options for coal combustion waste management in the Pacific Basin

BACKGROUND Accumulating evidence suggests that various epigenetic aberrations play definite roles in the pathogenesis of endometriosis. We investigated the histone acetylation status in endometriosis and the application of the histone deacetylase inhibitors (HDACIs) for the treatment of endometriosis. METHODS The levels of acetylated histones in the endometriotic cyst stromal cells (ECSCs) and normal endometrial stromal cells (NESCs) were evaluated. The effects of the HDACIs on cell proliferation, the cell cycle, apoptosis of ECSCs and NESCs, and the expression of genes related to these cellular events were investigated. The effects of HDACIs on histone acetylation in chromatin of the promoter region of the cell cycle regulatory genes in ECSCs were also investigated. RESULTS The acetylated histone levels were significantly lower in ECSCs than in NESCs (P endometriosis and that HDACIs reactivated epigenetically silenced genes, resulting in the suppression of cell ...

2011-06-29

485

An Overview of the Reliability and Availability Data System (RADS)

Many Pacific Basin countries rely on oil for electricity production. Alternative fuel sources such as coal, which is available in the Pacific Basin, can help mitigate adverse impacts of sudden price increases or supply disruptions. Coal combustion produces solid and potentially hazardous wastes of concern to environmental regulators and utility managers. This paper identifies issues associated with managing coal combustion wastes in the Pacific Basin, using the state of Hawaii as a case study. Hawaii is typical of many Pacific Basin locations in that it depends on oil, has limited sites, for waste management operations, and is subject to domestic and international waste management regulations. The paper discusses coal-fired utility wastes, environmental impacts of coal combustion waste disposal, and regulatory requirements that impact coal waste management. From this baseline, potential on- and off-island options for coal waste management are identified. Waste ...

1993-10-01

486

Alternative methods to determine headwater benefits

The Reliability and Availability Data System (RADS) is a database and analysis code, developed by the Idaho National Engineering and Environmental Laboratory (INEEL) for the U.S. Nuclear Regulatory Commission (USNRC). The code is designed to estimate industry and plant-specific reliability and availability parameters for selected components in risk-important systems and initiating events for use in risk-informed applications. The RADS tool contains data and information based on actual operating experience from U.S. commercial nuclear power plants. The data contained in RADS is kept up-to-date by loading the most current quarter's Equipment Performance and Information Exchange (EPIX) data and by yearly lods of initiating event data from licensee event reports (LERS). The reliability parameters estimated by RADS are (1) probability of failure on demand, (2) failure rate during operation (used to calculate failure to run probability) and (3) time trends in ...

2005-09-01

487

Alternative calcium-sulfate-bearing materials as cement retarders: Part II. FGD gypsum

In 1992, the Federal Energy Regulatory Commission (FERC) began using a Flow Duration Analysis (FDA) methodology to assess headwater benefits in river basins where use of the Headwater Benefits Energy Gains (HWBEG) model may not result in significant improvements in modeling accuracy. The purpose of this study is to validate the accuracy and appropriateness of the FDA method for determining energy gains in less complex basins. This report presents the results of Oak Ridge National Laboratory`s (ORNL`s) validation of the FDA method. The validation is based on a comparison of energy gains using the FDA method with energy gains calculated using the MWBEG model. Comparisons of energy gains are made on a daily and monthly basis for a complex river basin (the Alabama River Basin) and a basin that is considered relatively simple hydrologically (the Stanislaus River Basin). In addition to validating the FDA method, ORNL was asked to suggest refinements and improvements to ...

1997-11-10

488

Agile Energy Systems. Global Lessons from the California Energy Crisis

The aim of this paper is to investigate the possible displacement of natural gypsum (CaSO{sub 4}2H{sub 2}O) in cement with an alternative setting retarder, such as the industrial by-product derived from flue gas desulfurization process called FGD gypsum. These calcium-sulfate-bearing materials (CSBM), alone or in mixtures, were ground with clinker both in laboratory and industrial scale to examine their influence on the physical and mechanical properties of cement, as well as on the industrial production line of cement. From the present work, it is extracted that the use of mixtures of sulfate-bearing materials with gypsum seems to be advantageous for the actual control of setting time. The addition of FGD gypsum increases setting time without affecting compressive strength profile. During the industrial trial, the formation of hemihydrate form of calcium sulfate dihydrate has a profound regulatory effect on the setting and strength performance of the cement ...

2004-11-01

489

Adaptation of oral streptococci to low pH.

Due to the recent catastrophic energy system failures in California along with those in the North-Eastern US and Southern Canada, London, and Italy, the time has come to proclaim the failure of deregulation, privatization or liberalization and propose a new energy system. This book shows in the first section, how five precipitating forces led to the deregulation debacle in California: (1) major technological changes and commercialization, (2) regulatory needs mismatched to societal adjustments, (3) inadequate and flawed economic models, (4) lack of vision, goals, and planning leading to energy failures, and (5) failure and lack of economic regional development. The second half of the book, examines how 'civic market', new economic models, and planning for complexity as sustainable economic development transformed in California, the same five forces to create an 'agile energy system' based on renewable energy generation, hybrid or ...

2004-09-01

490

Activation of fat cell adenylate cyclase by protein kinase C

The strategies employed by oral streptococci to resist the inimical influences of acidification reflect the diverse and dynamic niches of the human mouth. All of the oral streptococci are capable of rapid degradation of sugar to acidic end-products. As a result, the pH value of their immediate environment can plummet to levels where glycolysis and growth cease. At this point, the approaches for survival in acid separate the organisms. Streptococcus mutans, for example, relies on its F-ATPase, to protect itself from acidification by pumping protons out of the cells. S. salivarius responds by degrading urea to ammonia and S. sanguis produces ammonia by arginolysis. The mechanisms by which these organisms regulate their particular escape route are now being explored experimentally. The picture that emerges is that the acid-adaptive regulatory mechanisms of the oral streptococci differ markedly from those employed by Gram-negative bacteria. What remains to be ...

2000-01-01

491

Accelerated aging tests of liners for uranium mill tailings disposal

Purified protein kinase C (C-kinase) from guinea pig pancreas and rat brain stimulated adenylate cyclase activity in purified rat adipocyte membranes. Cyclase stimulation occurred over 100 to 1000 mU/ml of C-kinase activity, required greater than 10 ..mu..M calcium, proceeded without a lag, was not readily reversible, and required no exogenous phospholipid. Moreover, C-kinase inhibitors, such as chlorpromazine and palmitoyl carnitine, inhibited selectively adenylate cyclase which was activated by C-kinase and calcium. Depending on assay conditions, 10 nM 12-0-tetradecanoylphorbol-13-acetate (TPA) either enhanced or was required for kinase action on cyclase. Also, TPA plus calcium promoted the quantitative association of C-kinase with membranes. Adenylate cyclase activation by C-kinase was seen both in the presence and absence of exogenous GTP, indicating that the kinase effect does not result from an action on the GTP-binding, inhibitory regulatory component (N/sub ...

1986-05-01

492

A thermochemical hydrogen production system based on a high-temperature fusion reactor blanket

This document describes the results of accelerated aging tests to determine the long-term effectiveness of selected impoundment liner materials in a uranium mill tailings environment. The study was sponsored by the US Department of Energy under the Uranium Mill Tailings Remedial Action Project. The study was designed to evaluate the need for, and the performance of, several candidate liners for isolating mill tailings leachate in conformance with proposed Environmental Protection Agency and Nuclear Regulatory Commission requirements. The liners were subjected to conditions known to accelerate the degradation mechanisms of the various liners. Also, a test environment was maintained that modeled the expected conditions at a mill tailings impoundment, including ground subsidence and the weight loading of tailings on the liners. A comparison of installation costs was also performed for the candidate liners. The laboratory testing and cost information prompted the ...

1981-11-01

493

A pilot application of risk-based methods to establish in-service inspection priorities for nuclear components at Surry Unit 1 Nuclear Power Station

A conceptual fusion synfuel production system has been developed with the unique features of: (1) a fusion blanket producing high-temperature (1250"0C) process heat, and (2) the GA sulfur-iodine thermochemical cycle. The system incorporates a two-zone blanket which achieves a tritium breeding ratio of 1.1 while delivering a high fraction (30%) of the fusion heat at high temperatures (1250"0C). The multiple barriers to tritium permeation in the blanket design permit the hydrogen product to meet 10CFR20 regulatory requirements without stringent requirements on the tritium recovery systems. A ceramic heat exchanger, incorporating SiC tubes and headers to contain the process stream and a cooled, Inconel 718 pressure shell to contain the helium, was designed for transferring the heat from the high-temperature coolant to the process. A good heat-line match of the blanket heatsource temperature distribution to the requirements of the thermochemical plant was attained ...

1983-04-26

494

A framework for assessing relative risks associated with multiple stressors in Port Valdez, Alaska

As part of the Nondestructive Evaluation Reliability Program sponsored by the US Nuclear Regulatory Commission, the Pacific Northwest Laboratory is developing a method that uses risk-based approaches to establish in-service inspection plans for nuclear power plant components. This method uses probabilistic risk assessment (PRA) results and Failure Modes and Effects Analysis (FEMA) techniques to identify and prioritize the most risk-important systems and components for inspection. The Surry Nuclear Power Station Unit 1 was selected for pilot applications of this method. The specific systems addressed in this report are the reactor pressure vessel, the reactor coolant, the low-pressure injection, and the auxiliary feedwater. The results provide a risk-based ranking of components within these systems and relate the target risk to target failure probability values for individual components. These results will be used to guide the development of improved inspection ...

495

A combined saline formation and gas reservoir CO2 injection pilotin Northern California

The purpose of this assessment is to develop a versatile process that will provide a mechanism for evaluating both present and future risks to this environment. Much of the regulatory and environmental interest in the port has centered around a Ballast Water Treatment facility that treats and discharges up to 30 mgd of oily ballast water brought in by crude oil tankers. However, six point discharges and other potential sources of pollution exist in the area. The authors have delineated eleven subareas in the port in order to identify the potential anthropogenic stressors, as well as the receptors that could be exposed to these stressors. Potential effects were then characterized for each exposure. Each component is ranked and integrated, resulting in a relative risk estimate in each subarea. Both the discernible risks, based on available data, and the data gaps are presented. Uncertainty is expressed as a range of high and low risk associated with each component. ...

1995-12-31

496

(Packaging regulations for chemical explosives)

A geologic sequestration pilot in the Thornton gas field in Northern California, USA involves injection of up to 4000 tons of CO{sub 2} into a stacked gas and saline formation reservoir. Lawrence Berkeley National Laboratory (LBNL) is leading the pilot test in collaboration with Rosetta Resources, Inc. and Calpine Corporation under the auspices of the U.S. Department of Energy and California Energy Commission's WESTCARB, Regional Carbon Sequestration Partnership. The goals of the pilot include: (1) Demonstrate the feasibility of CO{sub 2} storage in saline formations representative of major geologic sinks in California; (2) Test the feasibility of Enhanced Gas Recovery associated with the early stages of a CO{sub 2} storage project in a depleting gas field; (3) Obtain site-specific information to improve capacity estimation, risk assessment, and performance prediction; (4) Demonstrate and test methods for monitoring CO{sub 2} storage in saline formations and storage/enhanced ...

2006-04-28

497