International Nuclear Information System (INIS)

CBA/Ca mice were infected by either the intravenous or intraperitoneal route with Mycobacterium microti and the subsequent changes in local macrophage populations examined. Following infection, the number of macrophages increased and they showed greater expression of both MHC Class II molecules. This response was not dependent on viability of the mycobacteria, in contrast to reports with other microorganisms such as Listeria. Studies in sublethally irradiated mice indicated that persistent antigen could give rise to a response after a period of host recovery which was radiation dose dependent. This procedure also highlighted differences in the regulation of different murine class II antigens in vivo, as seen by delayed re-expression of I-E antigens. Macrophage accessory cell function, as assessed by an in vitro T cell proliferation assay, correlated with Ia expression after fixation, but not after indomethacin treatment; ...

UK PubMed Central (United Kingdom)

In monocytes, sulfatide, a lipid from Mycobacterium tuberculosis, blocked priming for enhanced release of superoxide (O2-) by the macrophage activating factors lipopolysaccharide, gamma interferon,...Full Text Available

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... Materials (PREM) Synopsis of Program: The objective of PREM is to enhance diversity in materials ... careers in materials research.The Partnerships for Research and Education in Materials (PREM ...

International Nuclear Information System (INIS)

Early effects of boron neutron capture therapy (BNCT) on malignant glioma are characterized by reduction of the enhancement area and regression of the peritumoral edema radiologically. The aim of this study was to investigate the early histological changes of tumors and inflammatory cells after BNCT in the rat brain. Rats were treated with BNCT using boronophenylalanine (BPA) 7 days after implantation of C6 glioma cells. The tumors were assessed with magnetic resonance imaging and histopathological examination at 4 days after BNCT. The mean tumor volumes were 39#+-#2 mm"3 in the BNCT group and 134#+-#18 mm"3 in the control group. In the BNCT group, tumor cells showed a less pleomorphic appearance with atypical nuclei and mitotic figures. The Ki-67 labeling index was 6.5%#+-#4.7% in the BNCT and 35%#+-#3.8% in the control group. The reactions of the inflammatory cells were examined with ED-1 as macrophage marker and OX42 as microglia marker. ...

Energy Technology Data Exchange (ETDEWEB)

A diverse set of digital image-processing applications exists at the Lawrence Livermore National Laboratory. While many of these include some sort of image analysis or restoration, virtually all of them require image-enhancement procedures. In this paper we describe the principal image-processing facility at the Laboratory, followed by a discussion of several of the major image-processing application areas.

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Previous studies suggest that the radiosensitivity and origin of tissue macrophage precursors differ from those of hemopoietic macrophage colony-forming units (CFU-Ms) committed to macrophage-lineage cells. We assessed the origins of tissue macrophage colony-forming cells (M-CFCs) in mice by comparing their kinetics and radiosensitivities in the normal steady state and under the conditions of bone marrow depletion by [sup 89]Sr-administration and/or splenectomy. The results indicate that the radiosensitive peritoneal M-CFCs elicited by thioglycollate are derived from bone marrow macrophage precursors; where as alveolar M-CFCs, which are radioresistant, are self-sustained locally and independent of hemopoietic macrophage precursors. In contrast, highly radiosensitive liver M-CFCs are probably derived from CFU-Ms that appear to be propagated in the spleen in ...

UK PubMed Central (United Kingdom)

The effect of Escherichia coli lipopolysaccharide (LPS) on the expression of major histocompatibility complex (MHC) class II molecules by bovine mammary macrophages was examined. The ability of LPS-treated...Full Text Available

UK PubMed Central (United Kingdom)

To confirm that Mycobacterium tuberculosis chaperonin 10 (Cpn10) is secreted outside the live bacillus, infected macrophages were examined by electron microscopy. This revealed that...Full Text Available

UK PubMed Central (United Kingdom)

The effect of Photofrin-based photodynamic therapy (PDT) and adjuvant treatment with serum vitamin D3-binding protein-derived macrophage-activating factor (DBPMAF) was examined using a mouse SCCVII...Full Text Available

UK PubMed Central (United Kingdom)

To study the expression of Fc receptors in human alveolar macrophages (AM), the cells were collected from 12 healthy controls and 22 patients with sarcoidosis and the activity involved in binding to...Full Text Available

UK PubMed Central (United Kingdom)

Macrophage phagocytosis is an essential biological process in host defense and requires large amounts of energy. To date, glucose is believed to represent the prime substrate for ATP production in macrophages....Full Text Available

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Chose the arid interior district Shiyang River basin four issues of Landsat/TM images from 1986 to 2006 to visually interpret, and analyze the natural succession of ecological environment and the landscape pattern characteristic under the human activity interference. The results showed that in past 20years, the number of landscape patch has increased, but the average patch size was decreasing, which explained that the landscape fragmentation degree was increasing, the landscape integrity was declining. The edge density of landscape remained invariable basically, which explained its stability maintained good. The diversity and evenness index continually enhanced, the diversity increased from 0.73 in 1986 to 0.84 in 2006. The mean core patch area of study area reduced from134.47hm2 in 1994 t...

Energy Technology Data Exchange (ETDEWEB)

This document describes an educational program designed to provide a pool of highly qualified administrative, technical, and managerial graduates that are familiar with the Hanford Site and business operations. The program is designed to provide work experience and mentoring to a culturally diverse student base which enhances affirmative employment goals. Short-term and long-term objectives of the program are outlined in the report, and current objectives are discussed in more detail. Goals to be completed by the year 2003 are aimed at defining the criteria necessary to establish partnerships between schools, community organizations, and human resources departments. Actions to be implemented includes providing instructors and equipment, enhancing skills of local teachers, and establishing collaboration with human resources organizations. Long-term goals of the program are to ensure a constant supply of qualified, trained ...

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... as far as mammary development is concerned but carries the NF-κB reporter, there is diffuse NF-κB activity throughout the epithelial tissue that is ...

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Immunomodulation by environmental chemical contaminants and the role immune parameters play in toxicity and risk assessment studies is of increasing concern. Although considerable evidence has indicated...Full Text Available

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... study is to collect data in previously harvested timber stands to quantify the differences in herbaceous diversity ... ...

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What technical, economic and institutional factors make radioactive and/or hazardous waste management technologies publicly acceptable? The goal of this paper is to initiate an identification of factors likely to render radioactive and hazardous waste management technologies publicly acceptable and to provide guidance on how technological R&D might be revised to enhance the acceptability of alternative waste management technologies. Technology development must attend to the full range of technology characteristics (technical, engineering, physical, economic, health, environmental, and socio-institutional) relevant to diverse stakeholders. ORNL`s efforts in recent years illustrate some attempts to accomplish these objectives or, at least, to build bridges toward the integrated design of waste management technologies.

Energy Technology Data Exchange (ETDEWEB)

Ternary diagrams or pseudo ternary diagrams are commonly used to provide a graphical representation of equilibrium fluid phase behavior for systems as diverse as distillation columns and miscible gas floods of oil reservoirs. The phase envelope and the position of the critical point on it are important to enhanced oil recovery engineers who are involved with miscible gas flood design. In the past, phase equilibrium data were laboriously plotted on the pseudo ternary diagram and special graphical techniques were utilized to locate the critical point on the phase envelope. Presented in this article is a computerized curve fitting method to, firstly, generate the phase envelope from a given set of phase equilibrium data and then use the 'tie-line slopes' to position the critical point. Experimental data are included and show excellent agreement with this new method.

International Nuclear Information System (INIS)

In this work the calculation of the average precipitation in the Quito River basin, state of Choco, Colombia, is presents through diverse techniques, among which are those suggested by Thiessen and those based on the isohyets analysis, in order to select the one appropriate to quantification of rainwater available to the basin. Also included is an estimation of the error with which the average precipitation in the zone studied is fraught when measured, by means of the methodology proposed by Gandin (1970) and Kagan (WMO, 1966), which at the same time allows to evaluate the representativeness of each one of the stations that make up the rain gauge network in the area. The study concludes with a calculation of the hydrologic balance for the Quito river basin based on the pilot procedure suggested in the UNESCO publication on the study of the South America hydrologic balance, from which the great contribution of rainfall to a greatly enhanced ...

Science.gov (United States)

Streptococcus pneumoniae colonizes the mucosal surface of the human upper respiratory tract. A colonization event is gradually cleared through phagocytosis by monocytes/macrophages that are recruited to the airway lumen. Here, we sought to define the bacterial and host factors that promote monocyte/macrophage influx and S. pneumoniae clearance using intranasal bacterial challenge in mice. We found that the recruitment of monocytes/macrophages required their expression of the chemokine receptor CCR2 and correlated with expression of the CCR2 ligand CCL2. Production of CCL2 and monocyte/macrophage recruitment were deficient in mice lacking digestion of peptidoglycan by lysozyme (LysM) and cytosolic sensing of the products of digestion by Nod2. Ex vivo macrophages produced CCL2 following bacterial uptake, digestion by LysM, and sensing of peptidoglycan by Nod2. Sensing of digested ...

British Library Electronic Table of Contents (United Kingdom)

Cancer cells recruit monocytes, macrophages and other inflammatory cells by producing abundant chemoattractants and growth factors, such as macrophage colony-stimulating factor (M-CSF/CSF-1) and monocyte chemoattractant protein-1 (MCP-1/CCL2), to promote tumor growth and dissemination. An understanding of the mechanisms that target cancer cells and regulate tumor microenvironment is essential in designing anticancer therapies. Here, we showed that serum amyloid-A (SAA) and cathelicidin (LL-37) stimulated M-CSF and MCP-1 expression with or without lipopolysaccharide (LPS) administration; conversely, lipoxin-A4 (LXA4) and annexin-A1 (ANXA1) inhibited LPS-induced M-CSF and MCP-1 production by human (HepG2) and mouse (H22) hepatocellular carcinoma cells (HCCs). The effects of LXA4, ANXA1, SAA ...

International Nuclear Information System (INIS)

As part of their corporate policy on environmental protection, Chevron, has taken an approach to work collaboratively with other industry members, universities and government agencies in phytoremediation research. The petroleum industry is interested in the integration of phytoremediation with the many biotechnology treatment technologies currently being used by the industry. Phytoremediation is a complex technology that does not just transfer wastes to another site, but offers in-situ final use and disposal treatment at sites anywhere in the world. Sites for potential remediation range from abandoned large refineries, chemical plants, or small urban gas stations. Research has focused on the cleanup of metals and hydrocarbons in diverse types of soil, water and groundwater conditions. This includes research into remediation of petroleum contaminants such as total petroleum hydrocarbon (TPH), polynuclear aromatic hydrocarbons as well as benzene in soil and the ...

UK PubMed Central (United Kingdom)

Macrophage activation by the proinflammatory cytokine interferon-γ (IFN-γ) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature...Full Text Available

UK PubMed Central (United Kingdom)

The use of infectious pathogens has allowed the detection of the development of synergism between pathogens and ubiquitous environmental chemical contaminants. This synergism has been demonstrated to...Full Text Available

UK PubMed Central (United Kingdom)

Despite the demonstrated clinical efficacy of CD20 monoclonal antibody (mAb) for lymphoma therapy, the in vivo mechanisms of tumor depletion remain controversial and variable. To identify the molecular...Full Text Available

UK PubMed Central (United Kingdom)

Exteriorized phosphatidylserine (PS) residues in apoptotic cells trigger rapid phagocytosis by macrophage scavenger receptor pathways. Mimicking apoptosis with liposomes containing PS may represent...Full Text Available

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PurposeTo address the roles of the stromal derived factor-1 (SDF-1) α in the course of experimental corneal neovascularization (CNV).MethodsCNV...Full Text Available

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The role of intracellular Ca2+ (Ca2+i) on hematopoiesis was investigated in long term bone marrow cultures using cytokines and agonists of P2 receptors. Cytokines interleukin 3 and granulocyte/macrophage colony stimulator factor promoted a modest increase in Ca2+i concentration ([Ca2+]i) with activation of phospholipase Cgamma, MEK1/2, and Ca2+/calmodulin kinase II. Involvement of protein kinase C was restricted to stimulation with interleukin 3. In addition, these cytokines promoted proliferation (20 times) and an increase in the Gr-1(-)Mac-1+ population with participation of gap junctions (GJ). Nevertheless ATP, ADP, and UTP promoted a large increase in [Ca2+]i, moderate proliferation (6 times), a reduction in the primitive Gr-1(-)Mac-1(-)c-Kit+ population, and differentiation into macrophages without participation of GJ. It is likely that Ca2+i participates as a regulator of hematopoietic signaling: moderate increases in [Ca2+]i would be ...

UK PubMed Central (United Kingdom)

The aggregation substance (AS) of Enterococcus faecalis, encoded on sex pheromone plasmids, is a surface-bound glycoprotein that mediates aggregation between bacteria thereby facilitating...Full Text Available

International Nuclear Information System (INIS)

An in vitro system for studying Pu uptake by, and removal from, macrophages was developed to provide data for the actinide therapy program. We have shown that "2"3"9PuO_2 particle uptake in vitro resembles the process in vivo with respect to the intracellular localization of phagocytized particles. At the end of 7 days of culture of Pu-loaded cells, 54% of the cells were viable even though 71% of the cells in the culture initially contained enough "2"3"9PuO_2 to deliver more than 53 intracellular #alpha#-disintegrations.

CERN Document Server

In this paper, we extend the diversity and multiplexing tradeoff (DMT) analysis from point-to-point channels to cellular systems to evaluate the impact of inter-cell interference on the system reliability and efficiency. Fundamental tradeoff among diversity order, multiplexing gain and inter-cell interference intensity is characterized to reveal the capability of multiple antennas in cellular systems. And the detrimental effects of the inter-cell interference on the system performance of diversity and multiplexing is presented and analyzed.

British Library Electronic Table of Contents (United Kingdom)

Emerging evidence suggests that E3 ligases play critical roles in diverse biological processes, including innate immune responses in plants. However, the mechanism of the E3 ligase involvement in plant innate immunity is unclear. We report that a rice gene, OsBBI1, encoding a RING finger protein with E3 ligase activity, mediates broad-spectrum disease resistance. The expression of OsBBI1 was induced by rice blast fungus Magnaporthe oryzae, as well as chemical inducers, benzothiadiazole and salicylic acid. Biochemical analysis revealed that OsBBI1 protein possesses E3 ubiquitin ligase activity in vitro. Genetic analysis revealed that the loss of OsBBI1 function in a Tos17-insertion line increased susceptibility, while the overexpression of OsBBI1 in transgenic plants conferred enhanced resi...

International Nuclear Information System (INIS)

Production treatment chemicals represent a diverse collection of chemical classes, added at various points from the wellhead to the final flotation cell, to prevent operational upsets and enhance the separation of oil from water. Information in the literature indicates that while many treatment chemicals are thought to partition into oil and not into the produced water, there are cases where a sufficiently water soluble treatment chemical is added at high enough concentrations to suggest that the treatment chemical may add to the aquatic toxicity of the produced water. A study was conducted to evaluate the potential effect of production treatment chemicals on the toxicity of produced waters using the US EPA Seven-day Mysidopsis bahia Survival, Growth and Fecundity Test. Samples of produced water were collected and tested for toxicity from three platforms under normal operating conditions, followed by repeated sampling and testing after a ...

Energy Technology Data Exchange (ETDEWEB)

The data and information collected for the Public Service Electric and Gas Company`s (PSE&G) electric vehicle demonstration program were intended to support and enhance DOE`s Electric and Hybrid Vehicle Site Operator Program. The DOE Site Operator Program is focused on the life cycle and reliability of Electric Vehicles (EVs). Of particular interest are vehicles currently available with features that are likely to be put into production or demonstrate new technology. PSE&G acquired eight GMC Electric G-Vans in 1991, and three TEVans in 1993, and conducted a program plan to test and assess the overall performance of these electric vehicles. To accomplish the objectives of DOE`s Site Operator`s test program, a manual data collection system was implemented. The manual data collection system has provided energy use and mileage data. From September 1991 to October 1994 PSE&G logged 69,368 miles on eleven test vehicles. PSE&G also demonstrated the EVs to ...

UK PubMed Central (United Kingdom)

For an enzyme functioning predominantly in a seemingly housekeeping role of 5′ tRNA maturation, RNase P displays a remarkable diversity in subunit make-up across the three domains of...Full Text Available

UK PubMed Central (United Kingdom)

There are many methods for introducing random mutations into nucleic acid sequences. Previously, we described a suite of programmes for estimating the completeness and diversity of randomized DNA libraries...Full Text Available

UK PubMed Central (United Kingdom)

A total of 295 ceftiofur-resistant Escherichia coli isolates were obtained from 489 cloacal samples collected at five different Belgian broiler farms with the aim to evaluate the diversity...Full Text Available

UK PubMed Central (United Kingdom)

The molecular diversity of the gene encoding the outer membrane protein A (OmpA) of Haemophilus parasuis has been unclear. In this study, the structural characteristics, sequence types,...Full Text Available

UK PubMed Central (United Kingdom)

The diversity of litter ant assemblages in evergreen, deciduous and Shola evergreen (Shola) forest vegetation types of the Wayanad region of the Western Ghats was assessed employing conventional and...Full Text Available

DEFF Research Database (Denmark)

Udgivelsesdato: 2002-Aug

Energy Technology Data Exchange (ETDEWEB)

The importance of ecosystem restoration to land reclamation is discussed. If a plant community is to be self sustaining, natural diversity processes provide a useful model for restoration. Biodiversity is important for utilitarian, ecological, and ethical/aesthetic reasons. Issues that must be considered include sampling and management scales, the separate richness of the diverse array of species playing a role in ecosystem productivity and stability, and natural trends in diversity. Ecological restoration comprises two fundamental activities: management for some pre-disturbance level of biodiversity and the combination of species in a manner that is essentially experimental. Endeavours to restore biological diversity are a useful method of experimenting with the factors that control ecosystem structure and function. 21 refs.

International Nuclear Information System (INIS)

In this study, we measured the effects of different concentrations of paraquat (0,01 mM and 1,0 mM) on the 1-"1"4CO_2 and 6-"1"4CO_2 production of rabbit lung slices and isolated alveolar macrophages, in 20% and 95% oxygen phases respectively. A 95% oxygen phase induced an increase in the 6-"1"4C-glucose oxidation of control lung slices over a 3-hour period, while the increased activity of the pentose pathway over the first 2 hours started to decline during the third hour of incubation. Paraquat (1,0mM) in 20% oxygen caused a consistent increase in the 6-"1"4CO_2 production by lung slices, but in a 95% oxygen phase gradually inhibited the 6-"1"4C-glucose oxidation over a period of 3 hours. The pentose phosphate pathway was highly significantly stimulated by 1,0 mM paraquat in 20% and 95% oxygen over 3 hours. When isolated alveolar macrophages (viability 95%) were incubated in a 20% and 95% oxygen phase respectively, both the 6-"1"4C-glucose and ...

UK PubMed Central (United Kingdom)

The CNS is a unique organ due to its limited capacity for immune surveillance. As macrophages of the CNS, microglia represent a population originally known for the ability to assist neuronal stability,...Full Text Available

Science.gov (United States)

Directed evolution of proteins depends on the production of molecular diversity by random mutagenesis. While a number of methods have been developed for introducing this diversity, the best ways to sample it are not always clear. Here we used simple statistics to analyse completeness and diversity in randomized libraries generated by oligonucleotide-directed mutagenesis, error-prone polymerase chain reaction (epPCR) and in vitro recombination of highly homologous sequences. For oligonucleotide-directed mutagenesis, we derive equations to estimate how complete a given library is expected to be and also to predict the size of library required to give a fixed probability of being 100% complete. We describe the statistical bases for computer programs which estimate the number of distinct variants represented in epPCR and shuffled libraries, dubbed PEDEL and DRIVeR, respectively. These programs allow the user to calculate ...

CERN Document Server

We propose a simple and accurate method to evaluate the outage probability at the output of arbitrarily fading L-branch diversity combining receiver. The method is based on the saddlepoint approximation, which only requires the knowledge of the moment generating functions of the signal-to-noise ratio at the output of each diversity branch. In addition, we show that the obtained results reduce to closed-form expressions in many particular cases of practical interest. Numerical results illustrate a very high accuracy of the proposed method for practical outage values and for a large mixture of fading and system parameters.

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The EMS Energy Institute at The Pennsylvania State University (Penn State) has managed the Gas Storage Technology Consortium (GSTC) since its inception in 2003. The GSTC infrastructure provided a means to accomplish industry-driven research and development designed to enhance the operational flexibility and deliverability of the nation's gas storage system, and provide a cost-effective, safe, and reliable supply of natural gas to meet domestic demand. The GSTC received base funding from the U.S. Department of Energy's (DOE) National Energy Technology Laboratory (NETL) Oil & Natural Gas Supply Program. The GSTC base funds were highly leveraged with industry funding for individual projects. Since its inception, the GSTC has engaged 67 members. The GSTC membership base was diverse, coming from 19 states, the District of Columbia, and Canada. The membership was comprised of natural gas storage field operators, service ...

UK PubMed Central (United Kingdom)

Objective. To describe the diverse patterns observed with the use of autofluorescence fundus photography (FAF) in patients with Birdshot chorioretinopathy (BSCR). Methods....Full Text Available

UK PubMed Central (United Kingdom)

Described as the body's largest organ, the skin is strategically located at the interface with the external environment where it has evolved to detect, integrate and respond to a diverse range...Full Text Available

UK PubMed Central (United Kingdom)

Diverse cell polarity networks require positive feedback for locally amplifying distributions of signalling molecules at the plasma membrane1. Additional...Full Text Available

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Hie synthesis of diverse biologically important compounds, under condi- tions which existed on the earth in the initial period of its evolution, ha; ...

Science.gov (United States)

... Anastrepha fraterculus (Wiedemann) and Ceratitis capitata (Wiedemann), including Acca sellowiana (O. Berg) Burret, Campomanesia xanthocarpa O. Berg, Psidium ... ...

UK PubMed Central (United Kingdom)

Due to the serovar diversity in Haemophilus (H.) parasuis, it is difficult to develop a universal serological method for detection of this pathogen....Full Text Available

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Chapter 10 of the manual that describes on-the-ground operations that strengthen the likelihood that our forests will be healthier, more diverse, and ... ...

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A new simple multi-well plate-based assay to determine monocyte differentiation-inducing activity was developed. It is based on the increase of macrophage adherence after the induction of monocyte differentiation. The assay was conducted using a human monocytic leukemia cell line, THP-1, treated with either 12-O-tetradecanoylphorbol 13-acetate or cytokines, such as tumor necrosis factor-alpha and interferon-gamma. This method is sensitive and easy to perform, especially in case of analyzing a large number of samples. PMID:17920620

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Extracellular ATP stimulates transmembrane ion fluxes in the mouse macrophage cell line J774. In the presence of Mg2+, nonhydrolyzable ATP analogs and other purine and pyrimidine nucleotides do not elicit this response, suggesting the presence of a specific receptor for ATP on the macrophage plasma membrane. One candidate for such a receptor is the ecto-ATPase expressed on these cells. We, therefore, investigated the role of this enzyme in ATP-induced /sup 86/Rb+ efflux in J774 cells. The ecto-ATPase had a broad nucleotide specificity and did not hydrolyze extracellular ATP in the absence of divalent cations. /sup 86/Rb+ efflux was not blocked by inhibition of the ecto-ATPase and did not require Ca2+ or Mg2+. In fact, ATP-stimulated /sup 86/Rb+ efflux was inhibited by Mg2+ and correlated with the availability of ATP4- in the medium. In the absence of divalent cations, the slowly hydrolyzable ATP analogs adenosine 5'-(beta, ...

CERN Document Server

In this paper, we consider a $n_t\\times n_r$ multiple-input multiple-output (MIMO) channel subjected to block fading. Reliability (in terms of achieved diversity order) and rate (in number of symbols transmitted per channel use) are of interest in such channels. We propose a new precoding scheme which achieves both full diversity ($n_tn_r$th order diversity) as well as full rate ($n_t$ symbols per channel use) using partial channel state information at the transmitter (CSIT), applicable in MIMO systems including $n_rdiversity and improved coding gain through an optimization over the choice of constellation sets. The optimization maximizes $d_{min}^2$ for our precoding scheme subject to an energy constraint. The scheme requires feedback of $n_t-1$ angle parameter values, compared to $2n_tn_r$ real coefficients in case of full CSIT. Error rate ...

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Breast cancer progression is characterized by inappropriate cell growth. Normal cells cease growth after a limited number of cell divisions--a process called cellular senescence-while tumor cells may acquire the ability to proliferate indefinitely (immortality). Inappropriate expression of specific oncogenes in a key cellular signaling pathway (Ras, Raf) can promote tumorigenicity in immortal cells, while causing finite lifespan cells to undergo a rapid senescence-like arrest. We have studied when in the course of transformation of cultured human mammary epithelial cells (HMEC), the response to overexpressed oncogenic Raf changes from being tumor-suppressive to tumor enhancing, and what are the molecular underpinnings of this response. Our data indicate: (1) HMEC acquire the ability to maintain growth in the presence of oncogenic Raf not simply as a consequence of overcoming senescence, but as a result of a newly discovered step in the process of immortal ...

British Library Electronic Table of Contents (United Kingdom)

The immune system modulates many key biological processes in humans. However, the exact role of the immune system in particle-associated periprosthetic osteolysis is controversial. Human tissue retrieval studies, in vivo and in vitro experiments suggest that the immune response to polymer particles is non-specific and macrophage-mediated. Lymphocytes may modulate this response. However direct lymphocyte activation by polymer particle-protein complexes seems unlikely. However, metallic byproducts may complex with serum proteins and lead to a Type IV, lymphocyte-mediated immune reaction. In predisposed individuals, this reaction may rarely lead to persistent painful joint effusions, necessitating debridement and excision of the bearing surfaces of the prosthesis. In these patients, retrieved...

British Library Electronic Table of Contents (United Kingdom)

Objective: Atherosclerosis is an inflammatory disease, modulated by plaque stabilizing and de-stabilizing cell populations such as infiltrating monocytes and vascular smooth muscle cells (vSMCs). Transcription factors regulating proliferation and differentiation of atherosclerosis relevant cell types are of interest in this context. The forkhead box transcription factor FoxP1 modulates monocyte differentiation. We studied FoxP1 expression in atherosclerotic tissue, correlated FoxP1 expression with plaque characteristics and identified associations between FoxP1 and plaque proteins. Methods: 116 Atherosclerotic plaques from carotid endarterectomy samples were histologically classified (fibrous, fibroatheromatous, atheromatous) and subjected to semi-quantitative protein analysis. Macrophage,...

British Library Electronic Table of Contents (United Kingdom)

The present study describes pathologic findings and immunohistochemical diagnosis of canine visceral leishmaniasis (CVL) in 22 dogs who died naturally in the Aegean region of Turkey. At necropsy, lymphadenomegaly, hepatosplenomegaly, hepatic, and nephrosclerotic lesions were conspicuous. Histopathologically, chronic inflammatory reactions of the spleen, lymph nodes, bone marrow, liver, and skin were marked findings. Cytological and histological examinations showed macrophages loaded with Leishmania amastigotes in these organs. Immunohistochemistry revealed that immunolabeling of amastigotes and/or parasite antigen, especially in the lymph nodes, spleen, bone marrow, liver, and skin, and occasionally, in the kidneys, intestines and lungs. Our laboratory results showed that immunohistochemis...

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UK PubMed Central (United Kingdom)

Mating signals are often directed at numerous senses and provide information about species identity, gender, receptiveness, individual identity and mate quality. Given the diversity of colourful body...Full Text Available

UK PubMed Central (United Kingdom)

The diagnosis of viral causes of many infectious diseases is difficult due to the inherent sequence diversity of viruses as well as the ongoing emergence of novel viral pathogens, such as SARS coronavirus...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundVariation of gene number among species indicates that there is a general process of new gene origination. One of the major mechanism providing raw materials for the origin...Full Text Available

UK PubMed Central (United Kingdom)

Splice products of the Kiss1 protein (kisspeptins) have been shown to be involved in a diverse range of functions, including puberty, metastasis and vasoconstriction in large human arteries. Circulating...Full Text Available

UK PubMed Central (United Kingdom)

ATP-binding cassette transporters (ABC transporters) utilize the energy of ATP hydrolysis to translocate an unusually diverse set of substrates across cellular membranes. ABCA4, also known as...Full Text Available

Science.gov (United States)

... poly-chaete densities and diversity values, probably the oyster aquaculture in BF although not intensive has produced a ... faster (Díaz-Castañeda & Rodriguez-Villanueva 1998). However if oyster aquacultu...

UK PubMed Central (United Kingdom)

Analysis of the pulsed-field gel electrophoretic profiles of 82 pneumococcal isolates with reduced susceptibility to ciprofloxacin (RSC) and of 90 co-occurring susceptible isolates indicates a considerable...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundCastor bean (Ricinus communis) is an agricultural crop and garden ornamental that is widely cultivated and has been introduced worldwide. Understanding...Full Text Available

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PurposeIt has been demonstrated that mutations in deafness, autosomal recessive 31 (DFNB31), the gene encoding whirlin, is responsible for nonsyndromic hearing loss...Full Text Available

International Nuclear Information System (INIS)

French ... Orig. Title Scintigraphie osseuse quantifiee chez l'enfant et l'adolescent - repartition selon l'age des taux de fixation de diverses pieces osseuses normales.

UK PubMed Central (United Kingdom)

Phenazines are redox-active small molecules that play significant roles in the interactions between pseudomonads and diverse eukaryotes, including fungi. When Pseudomonas aeruginosa...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe genus Vibrio is a diverse group of Gram-negative bacteria comprised of 74 species. Furthermore, the genus has and is expected to continue expanding...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundNematoda diverged from other animals between 600–1,200 million years ago and has become one of the most diverse animal phyla on earth. Most nematodes are free-living...Full Text Available

UK PubMed Central (United Kingdom)

Norway spruce (Picea abies L. Karst) produces an oleoresin characterized by a diverse array of terpenoids, monoterpenoids, sesquiterpenoids, and diterpene resin acids that can protect...Full Text Available

UK PubMed Central (United Kingdom)

Using the photopigment melanopsin, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light to drive circadian clock resetting and pupillary constriction. We now...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundLake Tanganyika (LT) is the oldest of the African Rift Lakes and is one of the richest freshwater ecosystems on Earth, with high levels of faunal diversity and endemism....Full Text Available

UK PubMed Central (United Kingdom)

Recent technological advances have lead to the ability to generate large amounts of data for model and non-model organisms. Whereas, in the past, there have been a relatively small number of central...Full Text Available

UK PubMed Central (United Kingdom)

Aflatrem is a potent tremorgenic mycotoxin produced by the soil fungus Aspergillus flavus and is a member of a large structurally diverse group of secondary metabolites known as indole-diterpenes....Full Text Available

UK PubMed Central (United Kingdom)

Auxin modulates diverse plant developmental pathways through direct transcriptional regulation and cooperative signaling with other plant hormones. Genetic and biochemical approaches have clarified...Full Text Available

UK PubMed Central (United Kingdom)

Arbuscular mycorrhizal fungi (AMF) are ecologically important root symbionts of most terrestrial plants. Ecological studies of AMF have concentrated on differences between species; largely assuming...Full Text Available

UK PubMed Central (United Kingdom)

Mycobacterium ulcerans is the causative agent of Buruli ulcer, the third most common mycobacterial disease after tuberculosis and leprosy. It is an emerging infectious disease that...Full Text Available

UK PubMed Central (United Kingdom)

Neurofibromatosis type 1 (NF1) results from mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. NF1 patients display diverse clinical manifestations,...Full Text Available

Wastenet

... The costal plain still supports Jarrah (Eucalyptus marginata ) forest, dense woodlands, coastal heath and diverse swamplands. Many species of plants are endemic. 20 species of mammals and 12 species of introduced mammals including with feral pigs, rabbits and foxes of particular concern....

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The recent assembly of the silkworm Bombyx mori genome with 432 Mb on 28 holocentric chromosomes has become a reference in the genomic analysis of the very diverse Order of Lepidoptera....Full Text Available

UK PubMed Central (United Kingdom)

Loss of biological diversity because of extinction is one of the most pronounced changes to the global environment. For several decades, researchers have tried to understand how changes in biodiversity...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundCichlid fishes in Lake Tanganyika exhibit remarkable diversity in their feeding habits. Among them, seven species in the genus Perissodus are known for...Full Text Available

UK PubMed Central (United Kingdom)

Hematopoietic stem cells replenish all the cells of the blood throughout the lifetime of an animal. Although thousands of stem cells reside in the bone marrow, only a few contribute to blood production...Full Text Available

UK PubMed Central (United Kingdom)

Heart failure affects nearly 6 million Americans, with a half-million new cases emerging each year. Whereas up to 50% of heart failure patients die of arrhythmia, the diverse mechanisms underlying...Full Text Available

UK PubMed Central (United Kingdom)

The plant-parasitic nematode Heterodera schachtii stimulates plant root cells to form syncytial feeding structures which synthesize all nutrients required for successful nematode development....Full Text Available

UK PubMed Central (United Kingdom)

High-density lipoproteins (HDL) were examined as potential carriers of small peptides in plasma. HDL purified by density gradient centrifugation was delipidated and fractionated by size-exclusion...Full Text Available

UK PubMed Central (United Kingdom)

Many pathogens colonize different anatomical sites, but the selective pressures contributing to survival in the diverse niches are poorly understood. Group A Streptococcus (GAS) is...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundMicroorganisms display vast diversity, and each one has its own set of genes, cell components and metabolic reactions. To assess their huge unexploited metabolic potential...Full Text Available

UK PubMed Central (United Kingdom)

Evolutionary explanations for life history diversity are based on the idea of costs of reproduction, particularly on the concept of a trade-off between age-specific reproduction and parental survival,...Full Text Available

UK PubMed Central (United Kingdom)

We study the statistical properties of a variety of diverse real-world networks. We present evidence of the occurrence of three classes of small-world networks: (a) scale-free networks,...Full Text Available

UK PubMed Central (United Kingdom)

Early simian virus 40-specific mRNA was isolated from lytically infected and stably transformed cells and analyzed with respect to the 5'-terminal cap content. An analogous diversity of capped structures...Full Text Available

UK PubMed Central (United Kingdom)

The genomic termini of RNA viruses contain essential cis-acting signals for such diverse functions as packaging, genome translation, mRNA transcription, and RNA replication, and thus...Full Text Available

UK PubMed Central (United Kingdom)

Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells. By...Full Text Available

UK PubMed Central (United Kingdom)

In many eukaryotic mRNAs one or more short ‘upstream’ open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated...Full Text Available

UK PubMed Central (United Kingdom)

KLF1 regulates a diverse suite of genes to direct erythroid cell differentiation from bipotent progenitors. To determine the local cis-regulatory contexts and transcription factor networks...Full Text Available

UK PubMed Central (United Kingdom)

The decline in immune function with aging, known as immunosenescence, has been implicated in evolutionarily diverse species, but the underlying molecular mechanisms are not understood. During aging...Full Text Available

International Nuclear Information System (INIS)

Nuclear forensics aims at identifying origin and intended use of nuclear material using information inherent to the nuclear material.The information gathered in nuclear forensics include isotopic composition, elemental composition, impurities and age of the material, macroscopic appearance and microstructure. The information so collected helps to solve criminal cases and put the individuals involved in nuclear trafficking in jails. The information also helps to improve safeguards and physical protection measures at place of theft or diversion to prevent future thefts or diversions.

Energy Technology Data Exchange (ETDEWEB)

In this experiments, we established long-termed culture methods of bone marrow stromal cells for proliferation and differentiation of stem cells. And we selected some extracts which support maximal proliferation of stromal cells with this method. We conformed the synergic effects of herval mixture extracts for stromal cell growth. The proliferation of stromal cells was increased rather by the addition of mixture extracts than by addition of single strain extract. In the previous and cooperative experiments, we selected complex extracts which increased the number of nonadherent mononuclear cells. Different cytokine expression patterns were observed stromal cells cultured in the presence or absence of mixture extracts which support differentiation of nonadherent cells. Stimulation of macrophage cell line with herval extracts with the treatments of recombinant interferon-{gamma} resulted in increased nitric oxide synthesis in a dose-dependent manners. In addition, ...

Energy Technology Data Exchange (ETDEWEB)

The goal of this program was to increase the high-temperature strength of the H-Series of cast austenitic stainless steels by 50% and upper use temperature by 86 to 140 F (30 to 60 C). Meeting this goal is expected to result in energy savings of 38 trillion Btu/year by 2020 and energy cost savings of $185 million/year. The higher strength H-Series of cast stainless steels (HK and HP type) have applications for the production of ethylene in the chemical industry, for radiant burner tubes and transfer rolls for secondary processing of steel in the steel industry, and for many applications in the heat-treating industry. The project was led by Duraloy Technologies, Inc. with research participation by the Oak Ridge National Laboratory (ORNL) and industrial participation by a diverse group of companies. Energy Industries of Ohio (EIO) was also a partner in this project. Each team partner had well-defined roles. Duraloy Technologies led the team by identifying the base ...

International Nuclear Information System (INIS)

A brief description of the physical process of dose enhancement effects produced by X-ray radiation on materials is given, with emphasis on the influence on electronic devices. The damages caused by X-ray radiation dose enhancement is more serious than that of #gamma#-ray with higher energy.

UK PubMed Central (United Kingdom)

OBJECTIVEPhosphoinositide 3-kinase enhancer A (PIKE-A) is a proto-oncogene that promotes tumor growth and transformation by enhancing Akt activity. However, the physiological functions...Full Text Available

KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

This is a report of 21 patients presenting with epigastric pain, bilious vomiting, upper gastrointestinal bleeding, iron-deficiency anemia, and weight loss, who had undergone Billroth II gastrectomy from 3 to 35 yr earlier. Eighteen of 21 patients were found to have significant enterogastric reflux indices varying from 60% to 95% demonstrated by /sup 99m/Tc HIDA scintigraphy. Thirteen patients had diversion antireflux surgery in the form of a Roux-en-Y procedure, and 1 patient had a Henley loop jejunal interposition. Postoperative /sup 99m/Tc HIDA scintigraphic studies showed the enterogastric reflux indices to have decreased significantly to a range of 2%-26% (p less than 0.00001). There was marked improvement of symptoms, including correction of anemia and weight gain in those patients who had been anemic or who had sustained earlier weight loss. The enterogastric reflux indices of 10 asymptomatic control patients after Billroth II gastrectomy ranged from 4% to ...

Energy Technology Data Exchange (ETDEWEB)

The diagnosis of idiopathic pulmonary hemosiderosis (IPH) may be elusive. A 6-year-old boy had microcytic hypochromic anemia and a hemolytic component. Hemosiderin-laden macrophages were not found in the gastric aspirate. He had no pulmonary signs or symptoms. Extensive hematologic and roentgenologic investigations failed to reveal the cause of the anemia. Quantitative serial scintigraphic scanning showed significant (35%) pulmonary sequestration of autologous erythrocytes labeled with sodium chromate Cr51. The half-life of the RBCs was moderately decreased (half-life, 15 days; normal, 25 to 35 days). An open-lung biopsy spece Cr51. The half-life of the RBCs was moderately decreased (half-life, 15 days; normal, 25 to 35 days). An open-lung biopsy specimen confirmed the diagnosis of IPH. A diagnosis of IPH should be considered when children have iron deficiency anemia and pulmonary signs or symptoms. Organ sequestration studies may be helpful in equivocal cases.

Energy Technology Data Exchange (ETDEWEB)

Patients with acquired immunodeficiency syndrome (AIDS) are subject to a spectrum of central nervous system (CNS) disorders. Recent evidence implicates the human T-cell lymphotropic virus type III (HTLV-III) in the pathogenesis of some of these illnesses, although the cells infected by the virus have yet to be identified. Using in situ hybridization, the authors examined brain tissue from two patients with AIDS encephalopathy for the presence of HTLV-III RNA. In both cases, viral RNA was detected and concentrated in, though not limited to, the white matter. The CNS cells most frequently infected included macrophages, pleomorphic microglia, and multinucleated giant cells. Less frequently, cells morphologically consistent with astrocytes, oligodendroglia, and rarely neurons were also infected. The findings strengthen the association of HTLV-III with the pathogenesis of AIDS encephalopathy. In situ hybridization can be applied to routinely prepared biopsy tissue in ...

Science.gov (United States)

As care shifts from institutional to home- and community-based settings, consumer health information technology (IT) must be designed to support patients' new health information management responsibilities. We developed and piloted a new methodology grounded in social network analysis and human factors engineering to explore two often overlooked aspects of this phenomenon: the task of health information communication with members of the social network and the context of culture. Such knowledge is necessary to inform the appropriate design of consumer health IT. We asked a culturally diverse sample of participants to describe what, to whom, why, and how they communicate health information and to provide direct feedback about the methodology. The methodology was acceptable to all participants and able to capture similarities and differences in their health information communication practices. Prior to the main study we will need to refine the methodology to further ...

Energy Technology Data Exchange (ETDEWEB)

Information about current and projected waste generation as well as available treatment, storage, and disposal (TSD) capabilities and needs is crucial for effective, efficient, and safe waste management. This is especially true for large corporations that are responsible for multisite operations involving diverse and complex industrial processes. Such information is necessary not only for day-to-day operations, but also for strategic planning to ensure safe future performance. This paper reports on some methods developed and successfully applied to obtain requisite information and to assist waste management planning at the corporate level in a nationwide system of laboratories and industries. Waste generation and TSD capabilities at selected US Department of Energy (DOE) sites were studied. 1 ref., 2 tabs.

British Library Electronic Table of Contents (United Kingdom)

This article explores the extent to which and how non-formal education (NFE) contributes to the development of a more diversified basic education system and thus to the achievement of EFA. It outlines the current nature of NFE, the frameworks provided by the EFA movement, and the evolution of reflection, policies and practices in NFE in relation to basic education as a whole. Based on significant developments in various countries across the South, the article also discusses some key challenges that ministries of education and their partners need to face in moving towards relevant and equitable diversity in education. The article posits that, despite the many problems faced by NFE, there is justification for building on its experiences and integrating these within a larger policy and system...

International Nuclear Information System (INIS)

By using a variational Monte Carlo method, we examine an effective low-energy model for LaFeAsO derived from an ab initio downfolding scheme. We show that quantum and many-body fluctuations near the antiferromagnetic (AF) quantum critical point largely reduce the antiferromagnetic ordered moment. Our derived model not only quantitatively reproduces the small ordered moment in LaFeAsO, but also accounts for the diversity from LaFePO, BaFe_2As_2 to FeTe. Electron correlation is found to determine the observed material dependence. We also find that LaFeAsO is subject to large orbital fluctuations, sandwiched by the AF Mott insulator and weakly correlated metals. The orbital fluctuations and Dirac-cone dispersion hold keys for the diverse magnetic properties. (author)

International Nuclear Information System (INIS)

Diurnal and seasonal thermal constancy, a greatly delayed seasonal temperature maximum, and summer cool and winter warm conditions characterize the stream environment below a deep-release dam in Colorado. Low diversity index and equitability values and changes in macroinvertebrate species composition may result from failure of the temperature regime to provide the thermal stimuli essential for various life-cycle phenomena. It is hypothesized that the following sublethal effects, directly or indirectly resulting from the modified temperature regime, may further alter macroinvertebrate community structure: reduction of niche overlap and a shift toward an equilibrium community as a consequence of reduced environmental fluctuation; more intense competition associated with greater productivity; elimination of major invertebrate predators; and failure of the limited temperature range to provide optimal temperatures for various physiological processes. Effects of the ...

Environmental Research Database

ObjectivesCoastal ecosystems in developing countries supply a diverse range of services to local communities and national economies, including fish production, protection against floods and storms and support to tourism. Multiple drivers of change are influencing the status of the ecosystems, most of which are anthropogenic (Brown et al., 2006). Managing coastal ecosystems requires recognition of the diverse range of uses and users, and coordination between structures and processes, many of which are curr [continued...]DescriptionCommitment to the management of coastal ecosystems through addressing both ecological and social objectives already exists in East and Southern Africa (Glavovic 2006; Gustavson et al. 2009). More understanding, however, of the ecosystem services of priority to the poor and to poverty alleviation would strengthen the capacity of these initiatives to deliver on poverty alleviation and resource sustainability. The coastal ...

British Library Electronic Table of Contents (United Kingdom)

Action potentials from the brain control the activity of spinal neural networks to produce, by as yet unknown mechanisms, a variety of motor behaviors. Particularly lacking are details on how identified descending neurons integrate diverse sensory inputs to generate specific locomotor patterns. We have examined the operations of the principal neurons in an intriguing midbrain nucleus, the nucleus of the medial longitudinal fasciculus (nMLF), in the larval zebrafish. The nMLF is the most rostral grouping of neurons that projects from the brain well into the spinal cord of teleost fishes, yet there is little direct physiological data available regarding its function. We report here that a distinct set of large, individually-identifiable neurons in nMLF (the MeL and MeM neurons) are activated...

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

KoreaScience (Korea)

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CERN Document Server

Using spectral hole-burning-based ultraslow group velocity in a dilute solid medium, we report enhanced photon echo efficiency three orders of magnitude higher than that in a nonslow light regime. The enhancement is due to exponentially increased absorption of an optical data pulse owing to the enhanced photon-atom interaction in an ultraslow light regime, whereas echo reabsorption is negligibly small due to group-velocity dependent population depletion.

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Norwegian Open Research Archives (NORA)

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Science.gov (United States)

Contacts with researchers, manufacturers, and users of enhanced heat transfer equipment are summarized. The Technical Literature file and the Patent File continue to be updated; the Patent File is the source for a patent technology report now in draft form. Application studies on a rationally-based friction correlation for internally-finned tubes and on the evaluation of candidate tube-side enhancements for OTEC applications are reported. The technology study on enhancement of spray evaporation is also discussed.

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

KoreaScience (Korea)

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UK PubMed Central (United Kingdom)

Aerobic chemoheterotrophic bacteria were isolated from surface soils and coastal plain subsurface (including deep aquifer) sediments (depths to 265 m) at a study site near Aiken, S.C., by plating on...Full Text Available

UK PubMed Central (United Kingdom)

Spider venoms provide a highly valuable source of peptide toxins that act on a wide diversity of membrane-bound receptors and ion channels. In this work, we report isolation, biochemical analysis, and...Full Text Available

Science.gov (United States)

The synthesis and structures of acyclic and macrocyclic thio-, seleno- and telluro-ether complexes of the metallic and metalloid elements of Groups 13-16 reported since 2000 are described. The diverse structures range from discrete monomers through to infinite 1-, 2- or 3-D polymers. The coordination chemistry in this area is quite different to familiar d-block chemistry and the underlying factors are explored. PMID:21706103

British Library Electronic Table of Contents (United Kingdom)

Cardiac tumours may display diverse symptoms through potential involvement of any structure of the heart. We describe a case of a highly malignant thymoma with involvement of different cardiac structures with important haemodynamic compromise. With the high sensitivity of transthoracic echocardiography for detection of intracardiac masses, computed tomography and magnetic resonance add essential structural preoperative information on the tumour and surrounding tissue as vessels, pleura, lung and mediastinum.

UK PubMed Central (United Kingdom)

A survey carried out in 2005 among members of a healthy population of children living in Bolivia and Peru revealed that fecal carriage of Escherichia coli strains resistant to expanded-spectrum...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

This study examined the life histories of a group of emerging scholars in the field of mathematics education who identify themselves as having a particular interest in and concern for issues of equity and diversity. Experiences of being the "other," "bearing witness" to "othering experiences," and "orienting experiences" in relation to issues of equity proved to be prominent themes in participants' life histories. These experiences were then linked to the positionality that these scholars now have in relation to their research in mathematics education.

Energy Technology Data Exchange (ETDEWEB)

This paper will describe the application of power generation by the use of microturbine technology by Capstone Turbine Corporation throughout South America. The purpose of this paper is to describe the technology and the experience gained over the last six years. The microturbines are power generation systems that produce energy from a diverse range of liquid or gaseous fuels. The generator is driven by a small gas turbine with a common shaft for the rotors of the generator and the engine. (author)

UK PubMed Central (United Kingdom)

AbstractThe gag p6 region of HIV-1 has various nonsubstitutionary mutations, including insertions, duplications, deletions, and premature stop codons. Studies have linked gag p6 mutations...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis....Full Text Available

UK PubMed Central (United Kingdom)

Genome-wide association studies (GWAS) have identified more than 2,000 trait-SNP associations, and the number continues to increase. GWAS have focused on traits with potential consequences for human...Full Text Available

UK PubMed Central (United Kingdom)

FMRFamide-related peptides (FaRPs) are a diverse and physiologically important class of neuropepeptides in the metazoa. In insects, FaRPs function as brain-gut neuropeptides and have been immunolocalized...Full Text Available

UK PubMed Central (United Kingdom)

ABSTRACTThe immune response to Neisseria gonorrhoeae is poorly understood, but its extensive antigenic variability and resistance to complement are thought to allow it...Full Text Available

CERN Document Server

The Advances in Library Administration and Organization Series provides a body of research literature that contributes to the base of organizational theory upon which library administrators rely. Its mix of contributions to the literature of library administration and organization is both diverse and eclectic. This volume of the series covers a variety of topics relating to the management of academic, public and school libraries

Energy Technology Data Exchange (ETDEWEB)

To assess whether ring enhancements of liver metastases on Mn-DPDP enhanced, early MR images were well visualized on delayed images, as compared with those of hepatocellular carcinomas (HCC), and to investigate the detection accuracy and conspicuity of each tumor. Twenty patients with liver metastases and 15 with HCC were studied by Mn-DPDP enhanced, T1-weighted MR images. Peripheral ring enhancement and conspicuity were investigated. Differences in detection accuracy and frequency of ring enhancement in liver metastases and HCC were assessed. In liver metastases (n= 69), 44 cases (63.8%) without ring enhancement and 25 (36.2%) with were noted on early images. Sixteen cases (23.2%) without ring enhancement, 38 (55.1%) with ring enhancement similar to the early images, and 15 (21.7%) with prominent ring ...

International Nuclear Information System (INIS)

The aim of the present study is to identify and characterize the antimalrial agents from traitional Sudanese medicinal plants. 49 plants parts representing 26 species from 15 families were extracted and screened for their in vitro antimalrial activity using P. falciparum strain 3D7 which is chloroquine sensitive and Dd2 strain which is chloroquine resistant and pyrimethamine sensitive.The plant species investigated exhibited diverse botanical families. They includes Annonaceae, Aristolochiaceae, Asteraceae, Balantiaceae, Caesalpiniceae, Celasteraceae, Cucurbitaceae, Fabaceae, Graminae, Meliaceae, Myrtaceae, Polygonaceae, Rubiaceae, Rutaceae, and simaroubaceae. The evaluation of these plants for their antimalarial activity and their effect on lymphocyte proliferation was carried out. 57 extracts were tested on the chloroquine sensitive strain (3D7). Where 34 extracts (59%) exhibited significant activity against 3D7 with IC_5_0 values #100 #mu# g/ml), where as ...

UK PubMed Central (United Kingdom)

A critical research priority for our field is to develop treatments that enhance cognitive functioning in schizophrenia and thereby attenuate the functional losses associated with the illness. In this...Full Text Available

UK PubMed Central (United Kingdom)

Pooling and synthesizing signals across different senses often enhances responses to the event from which they are derived. Here we examine whether multisensory response enhancements are attributable...Full Text Available

UK PubMed Central (United Kingdom)

Convection-enhanced delivery (CED) has emerged as a promising method of targeted drug-delivery for treating central nervous system (CNS) disorders, but the influence of brain structure on infusate...Full Text Available

Science.gov (United States)

This report results from a contract tasking Eindhoven University of Technology as follows: The contractor will investigate the plasma treatment of surfaces and plasma enhanced deposition using EUT's cascade arc source as the basis for this effort.

Science.gov (United States)

Established Investigators (K18) (PAR-09-090) NIH: Career Enhancement Award for Stem Cell Research (K18) (PA-09-110) NIDCD: NIDCD Research Career Enhancement Award for Established...

UK PubMed Central (United Kingdom)

BackgroundPolyadenylation of RNA has a decisive influence on RNA stability. Depending on the organisms or subcellular compartment, it either enhances transcript stability or targets...Full Text Available

UK PubMed Central (United Kingdom)

AIM: To improve the diagnosis of heterotopic pancreas by the use of contrast-enhanced computed tomography (CT) imaging and CT virtual endoscopy (CTVE).METHODS: A total of six patients with heterotopic...Full Text Available

UK PubMed Central (United Kingdom)

PurposeA major obstacle in glioblastoma (GBM) therapy is the restrictive nature of the blood-brain barrier (BBB). Convection-enhanced delivery (CED) is a novel method...Full Text Available

Science.gov (United States)

... Originator-supplied keywords include: Turbulators, Heat transfer augmentation, Enhancement, Fire tube boilers. (Author). ...

Science.gov (United States)

Seven papers were presented at the meeting. A separate abstract was prepared for each paper. (LCL)

International Nuclear Information System (INIS)

This paper describes Z-contrast scanning transmission electron microscopy used to study the connection between dopant precipitation and phase transformation in high dose In"+ and Sb"+ implanted Si. In the case of In, the observations confirm a heterogeneous nucleation model. Images of the precursor precipitates give the first measurement of the diffusion coefficient in amorphous Si, with an enhancement of 10"7 over tracer crystalline values. With Sb"+ implants enhanced homogeneous nucleation is observed. The connection between these results and the transient enhanced diffusion observed in crystallized Si is discussed.

International Nuclear Information System (INIS)

Japanese ... Authors Kuno, Yusuke; Esaka, Konomi (Tokyo Univ., Graduate School of Engineering, Tokyo (Japan))

Science.gov (United States)

... The realization of directional audio technology in the cockpit may reduce visual workload, enhance the presentation of flight and threat information ...

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Science.gov (United States)

This report describes work performed by MTC Technologies (MTCT) for NASA Glenn Research Center (GRC)

Science.gov (United States)

... Uninterrupted access to and use of critical infrastructure in the Arabian Gulf region are key to the successful prosecution of the Global War on Terror ...

International Nuclear Information System (INIS)

First results on the effects of strain on transient enhanced diffusion and deactivation of As-implanted ultrashallow junctions are presented. A significant effect of strain on the magnitude and timescale of transient enhanced diffusion is observed, which is consistent with the stabilization of interstitial-type defects by tensile strain. Our results show no significant impact of strain on As electrical activity during the deactivation timescale accessed in this study.

International Nuclear Information System (INIS)

The transient enhanced diffusion in crystalline silicon implanted with dopants ad followed by high temperature annealing to activate the dopants is introduced. The physical mechanisms of transient enhanced dopant diffusion are then reviewed together with a short introduction to the proposed suppressing methods. Finally, the perspectives with using high energy heavy ions in this field are briefly discussed

International Nuclear Information System (INIS)

Transient enhanced diffusion in boron-implanted silicon is interpreted as being due to the fact that during rapid thermal annealing a relaxation process takes place, associated with quasi-chemical reactions including defects. A simple analytical model makes it possible to describe the annealing mechanism on a microscopic scale in terms of reaction-diffusion processes. The measured dependences of the boron diffusion coefficient of the enhanced diffusion on time, temperature and implantation energy are satisfactorily explained. (author).

International Nuclear Information System (INIS)

Velocity field behind a flat plate, placed near the wall in a narrow channel as a simulant of a BWR fuel spacer, was measured by using a hot wire anemometer. It was found that not only the positions where the dead water region behind flat plate disappeared but also the locations where the velocity relaxation completed were almost independent of the width of the clearance, although the local average velocity and velocity fluctuation immediately downstream the flat plate were affected by the difference in the clearance. The transverse flow diversions in the channel cross section were evaluated from the shape of the average velocity profile. The decrease of local flow rate near the channel wall, which may causes the drift flow behind a flat plate, was encouraged as the drag of clearance increased. Attempts have been made to measure spanwise velocity in the narrow channel. A spanwise velocity that occurred due to flow diversion was observed and its ...

Energy Technology Data Exchange (ETDEWEB)

Open pit oil sands mining involves the disturbance of thin overburden covers of Boreal forest lands that must be returned to equivalent land capability after mining activities have ceased. Before mining starts, any wetlands are drained, timber is harvested, and peat, topsoils and subsoils are stockpiled for later use. This article discussed wetland reclamation activities conducted by Suncor Energy at its open pit mining operations. Research facilities were constructed in order to determine if wetlands constructed with consolidated tailings (CT) and pond effluent water (PEW) were able to support a sustainable vegetation community. Thirty-three cat-tail plots were established at the facility as well as unplanted plots in order to determine how quickly natural establishment occurred. Shoreline plug transplants and transplants from a natural saline lake were also introduced. Within 5 years, over 23 plant species had naturally colonized the CT wetlands. However, ...

International Nuclear Information System (INIS)

The concept of nanocrystal conversion chemistry, which involves the use of pre-formed nanoparticles as templates for chemical transformation into derivative solids, has emerged as a powerful approach for designing the synthesis of complex nanocrystalline solids. The general strategy exploits established synthetic capabilities in simple nanocrystal systems and uses these nanocrystals as templates that help to define the composition, crystal structure, and morphology of product nanocrystals. This article highlights key examples of 'conversion chemistry' approaches to the synthesis of nanocrystalline solids using a variety of techniques, including galvanic replacement, diffusion, oxidation, and ion exchange. The discussion is organized according to classes of solids, highlighting the diverse target systems that are accessible using similar chemical concepts: metals, oxides, chalcogenides, phosphides, alloys, intermetallic compounds, sulfides, and nitrides. - Graphical ...

British Library Electronic Table of Contents (United Kingdom)

Abstract Polymorphisms in the genomic DNA of eight varieties maintained by conventional bud propagation (via rhizomes) and by in vitro shoot tip cultures were detected by RAPD analysis of sugarcane varieties. The study estimated the genetic diversity induced after in vitro multiplication of these varieties. Higher (28.9%) and lower (12%) numbers of polymorphic bands were detected in plants propagated via rhizomes; the genetic similarity estimate varying from 0.63 to 0.80. Plants of SP90-3723 and SP91-1049, or RB85-5113 and SP90-3723, varieties involving greater genetic distances may be indicated as progenitors in breeding programmes. In vitro multiplication of RB86-7515, RB85-5113, RB83-5054 and SP86-42 varieties increases genetic variability, while in vitro multiplication of SP91-1049, SP...

International Nuclear Information System (INIS)

In 1990, field studies of water quality and stream macroinvertebrate communities were initiated in Sandia Canyon at Los Alamos National Laboratory. The studies were designed to establish baseline data and to determine the effects of routine discharges of industrial and sanitary waste. Water quality measurements were taken and aquatic macroinvertebrates sampled at three permanent stations within the canyon. Two of the three sample stations are located where the stream regularly receives industrial and sanitary waste effluents. These stations exhibited a low diversity of macroinvertebrates and slightly degraded water quality. The last sample station, located approximately 0.4 km (0.25 mi) downstream from the nearest wastewater outfall, appears to be in a zone of recovery where water quality parameters more closely resemble those found in natural streams in the Los Alamos area. A large increase in macroinvertebrate diversity was also observed at ...

Energy Technology Data Exchange (ETDEWEB)

Event-based biosurveillance is a scientific discipline in which diverse streams of data, available from the Internet, are characterized prospectively to provide information on infectious disease events. Biosurveillance complements traditional public health surveillance to provide both early warning of infectious disease events as well as situational awareness. The Global Health Security Action Group (GHSAG) of the Global Health Security Initiative is developing a biosurveillance capability that integrates and leverages component systems from member nations. This work discusses these biosurveillance systems and identifies needed future studies.

British Library Electronic Table of Contents (United Kingdom)

This forum showcases the work of a variety of different heritage-based centers, organizations, and projects dedicated to research, education, and preservation of tangible and intangible forms of cultural heritage. The descriptions of these centers demonstrate the diversity of heritage work being done today. The centers and projects described in the forum vary in their contexts, missions, and outcomes. Highlighted in the forum are preservation organizations, university-based heritage centers, and a global collaborative cultural heritage project. Each organization in the forum provides information about their missions and goals, their approaches or methods to heritage work, and a brief description of some of their initiatives.

British Library Electronic Table of Contents (United Kingdom)

Anxiety disorders are a highly prevalent and disabling class of psychiatric disorders. This review focuses on new directions in neurobiological research and implications for the development of novel psychopharmacological treatments. Neuroanatomical and neuroimaging research in anxiety disorders has centered on the role of the amygdala, reciprocal connections between the amygdala and the prefrontal cortex, and, most recently, alterations in interoceptive processing by the anterior insula. Anxiety disorders are characterized by alterations in a diverse range of neurochemical systems, suggesting ample novel targets for drug therapies. Corticotropin-releasing factor (CRF) concentrations are elevated in a subset of anxiety disorders, which suggests the potential utility of CRF receptor antagoni...

International Nuclear Information System (INIS)

A mixture of aminoacids was irradiated by a scattered proton beam, its energy varying from 4 to 6.6 MeV, by doses up to 5 x 10"1"1 proton/cm"2 for studying the potentiality of abiogenic synthesis of biologically important compounds in space. It was ascertained that increase in the radiation dose and reduction of proton energy involve increase in effectiveness both of destruction of the initial aminoacid (tryptophan, tyrosine, glycine) and synthesis of the relevant dipeptide. Essential influence of mineral substrate on abiogenic synthesis of natural nucleotides under the action of diverse energy sources was pointed out

Energy Technology Data Exchange (ETDEWEB)

This paper presents a framework for creating a common spatial canvass that can bring together considerations of resource availability, infrastructure reliability, and development costs while strategizing renewable energy investment. We describe the underlying models and methodologies that annotate an investment plan for potential sites over a time-period with costs and constraints which may be imposed on distance from infrastructure, system impact on infrastructure, and policy incentives. The framework is intended as an enabler for visualization, optimization and decision making across diverse dimensions while searching for lucrative investment-plans.

Energy Technology Data Exchange (ETDEWEB)

Knowledge integration is the process of incorporating new information into a body of existing knowledge. It involves determining how new and existing knowledge interact and how existing knowledge should be modified to accommodate the new information. KI is a machine learning program that performs knowledge integration. Through actively investigating the interaction of new information with existing knowledge KI is capable of detecting and exploiting a variety of diverse learning opportunities during a single learning episode. Empirical evaluation suggests that KI provides significant assistance to knowledge engineers while integrating new information into a large knowledge base.

Energy Technology Data Exchange (ETDEWEB)

This report contains a partial catalog of recent accomplishments of the U.S. Department of Energy's Office of Energy Efficiency and Renewable Energy (EERE)in collaboration with its many private- and public-sector partners. This compendium of success stories illustrates the range and diversity of EERE programs and achievements. Part of an ongoing effort, the principal goal of this collection is to provide stakeholders with the evidence they need to assess the value they are receiving from investments in these DOE programs. The report begins with an introduction and a description of the methodology. It then presents an overview of the accomplishments of EERE programs. This is followed by the stories themselves.

Energy Technology Data Exchange (ETDEWEB)

This proceedings volume contains contributions by about 70 authors on market trends, funding, marketing, boundary conditions and sales promotion of thermal solar energy and photovoltaic systems. The contributions reflect the diversity of authors, e.g. consultants, advocates and agents of solar technology producers and financial organisations. Central issues were markets in and outside Europe, quality assurance, interdepartmental cooperations, and marketing strategies of the solar industry. The proceedings volume also contains the conference schedule and self-descriptions of the authors' institutions. (orig.)

Energy Technology Data Exchange (ETDEWEB)

The report presents a long-range plan for a broad-based, coordinated research, development and market transformation program for reducing the lighting energy intensities in commercial and residential buildings in California without compromising lighting quality. An effective program to advance lighting energy efficiency in California must be based on an understanding that lighting is a mature field and the lighting industry has developed many specialized products that meet a wide variety of light needs for different building types. Above all else, the lighting field is diverse and there are applications for a wide range of lighting products, systems, and strategies. Given the range of existing lighting solutions, an effective energy efficient lighting research portfolio must be broad-based and diverse to match the diversity of the lighting market itself. The belief that there is one solution--a magic bullet, such as a ...

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Feline heartworm disease is a very different clinical entity from canine heartworm disease. In cats, the arrival and death of immature heartworms in the pulmonary arteries can cause coughing and dyspnea as early as 3 months postinfection. Adult heartworms suppress the function of pulmonary intravascular macrophages and thus reduce clinical disease in chronic feline heartworm infection. Approximately 80% of asymptomatic cats self-cure. Median survival time for symptomatic cats is 1.5 years, or 4 years if only cats living beyond the day of presentation are considered. Aberrant worm migration is more frequent than it is in dogs, and sudden death can occur with no prior clinical signs. The bacterial endosymbiont Wolbachia likely contributes to the inflammatory pathology of heartworm disease, but its role is not yet fully clear. Unfortunately, the diagnosis, treatment, and management of feline heartworm disease are far from simple. Antemortem diagnosis is hampered by ...

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Scrotal skin of black Long-Evans rats and human thigh skin were maintained in vitro as organ cultures for as long as 14 days, and examined histologically using the combined skin splitting and Dopa techniques. Selected rat skin cultures received testosterone in the culture medium and/or were irradiated with ultraviolet light (290 to 320 nm uvl). With increased time in culture, scrotal melanocytes round up and there is an increase in epidermal pigmentation. Human skin behaves similarly; after eight days in vitro human melanocytes also become rounded, but remain strongly Dopa-positive. Addition of exogenous testosterone to cultured rat skin maintains dendritic morphology of melanocytes, but cell body size is still reduced. uvl irradiation stimulates melanocytes in rat skin cultures, maintaining their dendritic morphology and increasing epidermal and dermal pigmentation. Cultured skin receiving both uvl and testosterone illustrates a synergistic effect. Electron microscopic examination of ...

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This paper summarizes results of preliminary experiments to develop cytological and biochemical indicators for estimating damage to respiratory cells in test animals exposed by inhalation to toxic agents associated with nonnuclear energy production, the specific goal being the application of advanced multiparameter flow-systems technologies to the detection of early atypical cellular changes in lung epithelium. Normal Syrian hamster lung cell samples composed of histiocytes, leukocytes, macrophages, ciliated columnar cells, and epithelial cells were stained with fluorescent dyes specific for different biochemical parameters and were analyzed in liquid suspension as they flowed through a chamber intersecting a laser beam of exciting light. Multiple sensors measured the total or two-color fluorescence and light scatter on a cell-by-cell basis. Cellular parameters proportional to optical measurements (i.e., cell size, DNA content, total protein, nonspecific esterase ...

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Influenza virus infection during pregnancy has been implicated as one of cause of premature delivery, abortion and stillbirth. We have reported that cultured human fetal membrane chorion cells undergoing apoptosis by influenza virus infection secrete unidentified heat-stable monocyte differentiation-inducing (MDI) factors. In this study, cellular, biological and immunochemical characteristics of MDI factors were investigated using human monocytic leukemia THP-1 cells by nitroblue tetrazolium reduction and cell adhesion assays. The treatment of THP-1 cells with culture supernatants from the influenza virus-infected chorion cells induced the nitroblue tetrazolium reduction ability, which was inhibited by the addition of superoxide dismutase and diphenyleneiodonium chloride, an inhibitor for reduced nicotinamide adenine dinucleotide phosphate oxidase. The phenomenon was also observed in human peripheral blood monocytes and histiocytic leukemia U937 cells, but not in promyelocytic leukemia ...

International Nuclear Information System (INIS)

To analyze the enhancement patterns and morphology of peripheral cholangiocar-cinomas (CCs), as seen on three-phase helical CT. Three-phase helical CT scans of 25 cases of 24 patients with pathologically-proven CCs were retrospectively reviewed. After intravenous administration of contrast media, scans of the hepatic arterial phase (HAP) were obtained at 30 seconds, of the portal venous phase (PVP) at 70 seconds, and of the delayed phase (DP) at 3 minutes. Linear, dense, marginal enhancement was seen in 17 CCs (68%), mainly on HAP images (64%) while thick, band-like, peripheral enhancement was seen in 18 (72%), on either PVP (52%) or DP (44%). Internal enhancement was observed in 23 CCs (92%) on PVP (68%) and/or DP (88%), and 19 CCs (76%) among them showed incomplete enhancement of stippled and/or septated patterns. Most (76%) were seen throughout all three phases to be ...

International Nuclear Information System (INIS)

Heat transfer enhancement in a heat exchanger tube by installing a baffle is reported. The effect of baffle size and orientation on the heat transfer enhancement was studied in detail. Three different baffle arrangements were considered. The results show that for the vertical baffle, an increase in the baffle height causes a substantial increase in the Nusselt number but the pressure loss is also very significant. For the inclined baffles, the results show that the Nusselt number enhancement is almost independent of the baffle inclination angle, with the maximum and average Nusselt number 120% and 70% higher than that for the case of no baffle, respectively. For a given baffle geometry, the Nusselt number enhancement is increased by more than a factor of two as the Reynolds number decreased from 20,000 to 5000. Simulations were conducted by introducing another baffle to enhance heat ...

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The thermal and heat transfer characteristics of stearic acid during the solidification processes were investigated experimentally in a vertical annulus energy storage system. The temperature distribution and temperature variations with time at different radial positions during the freezing processes were obtained. The thermal characteristics of the stearic acid, including movement of the solid-liquid interface in the radial direction, and the effects of Reynolds number on the heat transfer parameters were studied. The heat flux was estimated by using a simple approximate model. A new copper fin was designed and fixed to the electrical heating rod to enhance the thermal conductivity of the stearic acid. The results show that the new fin can enhance both the conduction and the natural convection heat transfer of the PCM, and the enhancement factor during solidification is estimated to be as high as 250%. The effect of the ...

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Accurate modeling of the enhanced diffusion of boron during rapid thermal annealing has been accomplished by incorporating the effects of extended defect formation and annealing on enhanced diffusion into a multizone, semiempirical model. The multizone model divides the implant profile into three zones defining regions of different defects and diffusion enhancements. The model also contains the initial enhanced diffusion and the transient diffusion effects associated with the dissolution of defect clusters and the annealing of extended defects, respectively. The saturation time for transient-enhanced diffusion contains an exponential function of implant dose in order to model the increase in point defect generated with higher implant dose. As a result, the model accurately simulates the boron diffusion profile over a wide range of implant doses and also shows the immobile boron peak ...

International Nuclear Information System (INIS)

The author investigates the diffusion and damage-annealing characteristics as a result of boron implantation through a surface oxide into the silicon, a process that is commonly realized in the fabrication of p-n junctions. Defect structures were examined using plan-view and cross-section transmission-electron microscopies. It is shown that recoil-implanted oxygen plays a critical role in determining the above annealing characteristics. For instance, transient-enhanced diffusion of boron, as is widely observed for boron-implanted silicon, does not occur in the case of through-oxide implantation. The initial suppression of the defect-enhanced diffusion lasts for a limited period of time after which enhanced diffusion occurs again. The so-called incubated enhanced diffusion' is characterized as due to recoiled-oxygen precipitation-emitting point defect that enhances boron motion. The ...

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Transient, greatly enhanced diffusion has been observed on annealing solid-phase-epitaxial (SPE) grown Si-Sb alloys. This is shown to be due to a high concentration of interstitials being trapped during SPE regrowth. The migration enthalpy, for diffusion of Sb by an interstitialcy mechanism was measured as 1.8 +/- 0.2 eV. The interstitials eventually condensed into loops, marking the end of the transient. In a SPE grown Si-Bi alloy a similar transient enhanced diffusion was observed, with an activation energy of 2.0 +/- 0.2 eV, but no loops formed. 8 figures, 7 references.

International Nuclear Information System (INIS)

We report investigations of enhancement in material conversion efficiency of KDP for SHG applications. The limitation of conventional technique of growing KDP crystal was overcome in the present work by adopting a growth method to grow KDP directly in type-II phase matching direction. The conventional technique results in #approx#30% of the crystal volume usable for SHG applications whereas the present method has resulted in enhancing it to #approx#90%. The orientation of the element was confirmed by frequency conversion experiment using Nd:YAG laser. The UV-vis transmittance obtained was 92%. The interferometric results show that the crystals have excellent optical homogeneity.

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The authors measured the absorption of CO{sub 2} in alkaline 0.5 M/0.5 M sodium carbonate/bicarbonate buffers containing either saccharose and sodium arsenite or saccharose and formaldehyde. Absorption enhancement increased upon increasing the concentration of either of the catalysts, but the joint action of the two was always less than the sum of their individual effects, the difference being a function of the acidities and concentrations of the catalysts and the pH of the carbonate/bicarbonate buffer solution

International Nuclear Information System (INIS)

Several design options for improved passive circulation flow have been investigated for use in small, modular liquid metal cooled reactors (LMRs). The purpose is to enhance the transition to natural convection cooling following loss of forced circulation flow, reducing thermal transients experienced by the fuel and possibly eliminating the need for emergency pony-motor flow. Design details to minimize pressure drops may also enhance maximum equilibrium power levels possible under natural circulation only.

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... This must be taken a step further in counseling and other feedback and ... Record System Power Point Presentation ,www.armyppt.com/ncoer/6.htm ...

UK PubMed Central (United Kingdom)

In this article, transhumanism is considered to be a quasi‐medical ideology that seeks to promote a variety of therapeutic and human‐enhancing aims. Moderate conceptions are distinguished...Full Text Available

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Page 1. - AERE-' R-7310 THIS DOCUMENT 15 INTENDED FOR PUBLICATION IN THE OPEN LITERATURE. ... Y Page 3. AERE R I 7318 ...

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Udgivelsesdato: 2008-null

International Nuclear Information System (INIS)

English Jul 2001 p. 143-144 China Liu Changlong Academia Sinica,