WorldWideScience
1

Deforestation, floodplain dynamics, and carbon biogeochemistry in the Amazon Basin  

Science.gov (United States)

Three aspects of the physical geographic environment of the Amazon Basin are considered: (1)

1984-01-01

3

Biogeochemistry and Community Composition of Iron- and Sulfur-Precipitating Microbial Mats at the Chefren Mud Volcano (Nile Deep Sea Fan, Eastern Mediterranean)?  

UK PubMed Central (United Kingdom)

In this study we determined the composition and biogeochemistry of novel, brightly colored, white and orange microbial mats at the surface of a brine seep at the outer rim of the Chefren mud volcano....Full Text Available

2008-05-01

4

Oxygen dynamics in periphyton communities and associated effects on phosphorus release from lake sediments  

Energy Technology Data Exchange (ETDEWEB)

Periphyton is typically a heterogeneous assemblage of filamentous and single celled photoautotrophic and heterotrophic micoorganisms suspended in a mucopolysaccharide matrix which they produce. By definition, the assemblage is attached to a substratum such as rock, sediment, or plant in an aquatic environment. Microtechniques with high spatial and temporal resolution are required to define metabolic interactions among the heterotrophic and autotrophic constituents, and between periphyton and its environment. This study used oxygen sensitive microelectrodes with tip diameters of < 30 m to investigate the effects of photosynthesis and respiration on the oxygen dynamics of several diverse periphyton communities both in situ and in laboratory microcosms. A novel flow-through system that utilized TSP radiotracer and that permitted manipulation of the velocity, flushing rate, and oxygen concentration of overlying water was developed to investigate the role of ...

1986-01-01

5

Great Lakes | US EPA  

Wastenet

...EPA This Area You are here: EPA Home Great Lakes The Great Lakes - Superior, Michigan, Huron, Erie, and Ontario ...

6

Dosimetry of {sup 210}Po in humans, caribou, and wolves in northern Canada  

Energy Technology Data Exchange (ETDEWEB)

Effective doses from {sup 210}Po intake with caribou meat were determined for human residents in Baker Lake and Snowdrift in the Northwest Territories of Canada and compared to doses calculated from reported {sup 210}Po tissue activities in Alaskan and British residents. Effective doses were calculated to separate body tissues, using ICRP 60 human weighting factors and the ICRP 30 metabolic model for {sup 210}Po. Baker Lake and Alaskan effective doses were similar at 0.4 mSv y{sup {minus}1} and slightly higher than Snowdrift doses (0.3 mSv y{sup {minus}1}). Alaskan tissue activities indicated higher effective doses to liver, bone surfaces and red marrow and lower doses to spleen than the {sup 210}Po metabolic model (ICRP 1979a) predicts. Effective doses to Baker Lake and Snowdrift caribou and wolves, calculated from tissue activities, ranged from 7-20 mSv y{sup {minus}1} using human ...

1994-06-01

7

Hydrogeochemistry of seasonal variation of Urmia Salt Lake, Iran  

UK PubMed Central (United Kingdom)

Urmia Lake has been designated as an international park by the United Nations. The lake occupies a 5700 km2 depression in northwestern Iran. Thirteen permanent rivers flow into the lake. Water level...Full Text Available

9

Distinction of mining lakes in central Germany with remote sensing methods  

Energy Technology Data Exchange (ETDEWEB)

Mining lakes are of a world-wide challenging problem caused by the well known acid mine drainage (AMD) and the dynamics of it. In the past, there was no possibility to monitor these mining lakes for an investigation of chemical and biological parameters. But, in general, remote sensing methods are suitable for a monitoring of natural lakes, and now, at the first time, those can be used for a distinction of acid mining lakes in central Germany into different types. In acid mining lakes unusual absorption and scattering properties exist due to the water constituents which are quite different in their optical properties to those of natural lakes. The artificial lakes show high concentrations of metal ions and compounds. This fact was used to discriminate the mining lakes into initial stage, early stage, transitional state ...

2001-07-01

10

Utilization of a Marketing Strategy at Naval Regional Medical Center Great Lakes, Great Lakes, Illinois.  

Science.gov (United States)

The study examines the question of whether or not civilian marketing practices and principles can be applied in the military care setting. Using the NRMC Great Lakes as a basis, the answer is yes--consumers of military medical care are ready to be the rec...

1983-01-01

11

Mastacembelid eels support Lake Tanganyika as an evolutionary hotspot of diversification  

UK PubMed Central (United Kingdom)

BackgroundLake Tanganyika (LT) is the oldest of the African Rift Lakes and is one of the richest freshwater ecosystems on Earth, with high levels of faunal diversity and endemism....Full Text Available

12

Bathymetry and temperature of some glacial lakes in Wyoming  

UK PubMed Central (United Kingdom)

On the west flank of the Wind River Mountains, Wyoming, are several large lakes occupying glacially scoured depressions dammed by terminal moraines. Fremont, Willow, and New Fork Lakes, having maximal...Full Text Available

1980-04-01

13

Pesticide-induced immunotoxicity: are Great Lakes residents at risk?  

UK PubMed Central (United Kingdom)

Several organophosphate and organochlorine compounds, including pesticides commonly found in the Great Lakes basin, have the potential to induce immunotoxicity. Because of biomagnification and accumulation...Full Text Available

1995-12-01

14

Lipid Metabolism in Gestational Diabetes  

Science.gov (United States)

Gestational Diabetes; Hyperlipidemia

2010-11-30

15

The ecology of the coastal marshes of western Lake Erie: A community profile  

Energy Technology Data Exchange (ETDEWEB)

Lake Erie, the southernmost of the Laurentian Great Lakes, is narrow and relatively shallow in comparison to other Great Lakes. The lake experiences extreme water level fluctuations and storm energy restricts the development of wetlands to protected areas within embayments, lagoons, or behind barriers. However, coastal marshes of western Lake Erie fringe the shorelines of Michigan, Ohio, and Ontario and encompass an area of 268 km/sup 2/. This publication reviews the ecological data and information on the wetlands of Lake Erie, which are some of the more productive areas in the Great Lakes ecosystem. The geologic history of the Lake Erie leading to the development of wetlands, the present environment, and present wetland distribution are presented as background in the opening chapters. Biological information available ...

1987-02-01

16

Massachusetts lake classification program (revised). Final report  

Energy Technology Data Exchange (ETDEWEB)

In accordance with Public Law 95-217, Section 314 (the 'Clean Lakes' section of the 1977 Amendments to the Federal Water Pollution Control Act), the Massachusetts Division of Water Pollution Control developed a lake classification program based upon the trophic condition of all publicly owned freshwater lakes and ponds in the Commonwealth. This publication, produced and updated on an annual basis since 1976, is the result of that program.

1984-01-01

18

Fission-track study of the uranium bio-geochemistry in carbonates of Bikini and Enewetak Atolls. Progress report, July 1, 1974--December 31, 1975  

International Nuclear Information System (INIS)

Major contributions during this contract period have been in developing an analytical procedure for Pu measurement, and in applying the developed procedures to determining the plutonium concentration and distribution in coral from the Bikini Atoll. In conjunction with these contributions, measurements using the fission-track method have been made of the uranium distribution and concentrations in several carbonate samples from drill cores obtained from the Runit Island Enewetak Atoll. Petrographic studies on these drill core samples have been made to correlate the uranium data with the mineralogical data.

19

Fission-track study of the uranium bio-geochemistry in carbonates of Bikini and Enewetak Atolls. Progress report, July 1, 1974--December 31, 1975  

Science.gov (United States)

Major contributions during this contract period have been in developing an analytical procedure for Pu measurement, and in applying the developed procedures to determining the plutonium concentration and distribution in coral from the Bikini Atoll. In conjunction with these contributions, measurements using the fission-track method have been made of the uranium distribution and concentrations in several carbonate samples from drill cores obtained from the Runit Island Enewetak Atoll. Petrographic studies on these drill core samples have been made to correlate the uranium data with the mineralogical data. (auth)

1975-09-01

20

Pit Lake modelling phase 2 task A : validation and refinement of existing RMA10 and DYRESM Pit Lake hydrodynamic results[End Pit Lake phase 2 modelling  

Energy Technology Data Exchange (ETDEWEB)

This interim technical report presented a summary of results obtained from Pit Lake models developed from different simulation models. The models were used to predict stratification in a hypothetical Pit Lake. Predictions were used to assess the hydrodynamic similarities and differences between the 2 models and to determine if the models would produce similar stratification profiles for the Pit Lakes to previous models. Results showed that the models produced similar results for both temperatures and salinities. The main difference between the RMA10 and CE-QUAL-W2 model used in a previous study was found to be run time. A sensitivity analysis of the RMA10 and CE-QUAL-W2 model predictions was completed to assess the effects of segmentation; time step; lake surface area; lake orientation; and model coefficients or parameters. Results showed that the selected time step and model ...

2006-06-15

21

Sedimentation of the Enan suite of the lower to middle Jurassic and coal reserves of the southeastern margin of the Ordos basin (China)  

Energy Technology Data Exchange (ETDEWEB)

The studied coal bearing series has a parallel origin. The following facial complexes are isolated in its composition: lakes free of vegetation without coal interlayers; overgrown lakes of their margins which are poor in coals; swampy lakes, whose peat beds formed coal layers of shallow or moderate depth; channel sediments without coal layers and swamps from between channel spaces which created thick coal strata of high quality for which, however, a strong changeability in thickness is intrinsic. The coal strata are normally split towards the central parts of the lake basins and river channels. The coal presence of the suite is reduced along the section which is associated with the replacement of the lake swamp conditions of sedimentation by lake river conditions. A paleotectonic analysis established that the distribution of the zones richest in coal was ...

1983-01-01

22

Geomorphic and sedimentologic evidence for the separation of Lake Superior from Lake Michigan and Huron  

British Library Electronic Table of Contents (United Kingdom)

A common break was recognized in four Lake Superior strandplain sequences using geomorphic and sedimentologic characteristics. Strandplains were divided into lakeward and landward sets of beach ridges using aerial photographs and topographic surveys to identify similar surficial features and core data to identify similar subsurface features. Cross-strandplain, elevation-trend changes from a lowering towards the lake in the landward set of beach ridges to a rise or reduction of slope towards the lake in the lakeward set of beach ridges indicates that the break is associated with an outlet change for Lake Superior. Correlation of this break between study sites and age model results for the strandplain sequences suggest that the outlet change occurred sometime after about 2,400 calendar years...

2007-01-01

23

Assessing variability of water quality in a groundwater-fed perennial lake of Kashmir Himalayas using linear geostatistics  

British Library Electronic Table of Contents (United Kingdom)

This paper presents a study on Manasbal lake, which is one of the high altitude lakes in the Kashmir Valley, India. Eighteen water samples were analysed for major ions and trace elements to assess the variability of water quality of the lake for various purposes. Geostatistics, the theory of regionalized variables, was then used to enhance the dataset and estimate some missing spatial values. Results indicated that the concentration of major ions in the water samples in winter was higher than in summer. The scatter diagrams suggested the dominance of alkaline earths over the alkali elements. Three types of water were identified in the lake that are referred to as Ca?HCO3, Mg?HCO3 and hybrid types. The lake water was found to be controlled by rock?water interaction with carbonate lithology ...

2011-01-01

24

Biosynthesis and metabolism of salicylic acid.  

UK PubMed Central (United Kingdom)

Pathways of salicylic acid (SA) biosynthesis and metabolism in tobacco have been recently identified. SA, an endogenous regulator of disease resistance, is a product of phenylpropanoid metabolism formed...Full Text Available

1995-05-09

25

USGS Fact Sheet 040-02  

Science.gov (United States)

and streambed sediment samples 2-6. Graphs showing: 2. Cesium-137 profile in HOE core 3. PAH trends in Lake Houston cores 4. DDE trends in Lake Houston cores 5. Trends in six trace...

2011-08-27

26

Temperature profiles and bathymetry of some high mountain lakes  

UK PubMed Central (United Kingdom)

The ice cover in high mountain lakes breaks up and disappears in about an hour, in part because it has been divided into fragile vertical spindles, which are individual crystals. Contributing to this...Full Text Available

2000-06-06

27

Spawning seasons of Rasbora tawarensis (Pisces: Cyprinidae) in Lake Laut Tawar, Aceh Province, Indonesia  

UK PubMed Central (United Kingdom)

BackgroundRasbora tawarensis is an endemic freshwater fish in Lake Laut Tawar, Aceh Province, Indonesia. Unfortunately, its status is regarded as critical endangered...Full Text Available

28

Rapid evolution of sessility in an endemic species flock of the freshwater bivalve Corbicula from ancient lakes on Sulawesi, Indonesia  

UK PubMed Central (United Kingdom)

The fauna of ancient lakes frequently contains taxa with highly derived morphologies that resulted from in situ radiation of lacustrine lineages with high antiquity. We employed a molecular...Full Text Available

2006-03-22

29

EcoEarth.Info Environment Links: Water/Rivers  

Wastenet

... 03, 2001 | Rate It Lake Superior Streams http://www.lakesuperiorstreams.org/ (1 vote) interactively examine real-time water quality data from 5 ...north shore Lake Superior trout streams and learn about other streams in the region, how they \\

30

Does Water Hyacinth on East African Lakes Promote Cholera Outbreaks?  

UK PubMed Central (United Kingdom)

Cholera outbreaks continue to occur regularly in Africa. Cholera has been associated with proximity to lakes in East Africa, and Vibrio cholerae has been found experimentally to concentrate...Full Text Available

2010-08-05

32

Nuclear power plants connected with pumped storage plants by the inland lakes  

International Nuclear Information System (INIS)

Finnish (May 1971). Finland Kilpelaeinen, JE Imatran Voima Osakeyhtio,

1971-01-01

33

Sustained metabolic scope.  

UK PubMed Central (United Kingdom)

Sustained metabolic rates (SusMR) are time-averaged metabolic rates that are measured in free-ranging animals maintaining constant body mass over periods long enough that metabolism is fueled by food...Full Text Available

1990-03-01

34

Pulmonary metabolism of foreign compounds: its role in metabolic activation.  

UK PubMed Central (United Kingdom)

The lung has the potential of metabolizing many foreign chemicals to a vast array of metabolites with different pharmacological and toxicological properties. Because many chemicals require metabolic...Full Text Available

1990-04-01

38

Integration of metabolic databases for the reconstruction of genome-scale metabolic networks  

UK PubMed Central (United Kingdom)

BackgroundGenome-scale metabolic reconstructions have been recognised as a valuable tool for a variety of applications ranging from metabolic engineering to evolutionary studies....Full Text Available

41

USE OF ENVIRONMENTAL ISOTOPES TO DIFFERENTIATE WATER SOURCES AND CONSTRAIN THE WATER BUDGET AT THE SULPHUR BANK MERCURY MINE, CLEAR LAKE, CALIFORNIA  

Science.gov (United States)

The Sulphur Bank Mercury Mine (SBMM) is a 65 ha site located on the eastern shore of the Oaks Arm of Clear Lake, Lake County, California. Between 1864 and 1957, SBMM was the site of underground and open pit mining operations for S and Hg, coinciding with past and present hot spr...

42

OCETA ENVIRONMENTAL TECHNOLOGY PROFILES CATALOGUE  

Wastenet

... The short residence time ensures that no temperature increase occurs. The pattern of entrainment, along with natural currents results in oxygenation of the entire hypolimnion. Figure 4 is a simplified schematic of the Lake LungTM. Built in circulators allow the lake manager to adjust the depth of the epilimnion, and to elect whether or not to destratify the lake to prolong the spring and autumn turnover. ...

43

A Monte Carlo model for predicting water quality in mine pit lakes  

Energy Technology Data Exchange (ETDEWEB)

A model has been developed to predict the chemical composition of lakes that form in pyrite-bearing open-pit mines. Pyrite oxidation in wall rock releases sulfuric acid and metals, which mix with ground waters in the lake. Aqueous metal concentrations are calculated using MINTEQA2.

1995-12-01

44

Selenium Accumulation in Sea Ducks Wintering at Lake Ontario  

British Library Electronic Table of Contents (United Kingdom)

Numbers of wintering sea ducks, including buffleheads (Bucephala albeola; BUFF), common goldeneyes (Bucephala clangula; COGO), and long-tailed ducks (Clangula hyemalis; LTDU), increased substantially at Lake Ontario after Dreissenid mussels (Dreissena bugensis and D. polymorpha) colonized the Great Lakes. Invertebrates, including Dreissenid mussels, are major diving duck prey items that can transfer some trace elements, such as selenium (Se) to higher trophic levels. Se can be problematic for waterfowl and it often has been detected at elevated levels in organisms using the Great Lakes. There are, however, few data on hepatic Se concentrations in sea ducks, particularly during the winter at Lake Ontario. In this study, we evaluated interspecific differences and temporal trends in hepatic S...

2010-01-01

45

Pit lakes: their characteristics and the potential for their remediation  

Energy Technology Data Exchange (ETDEWEB)

Pit lakes form when open-pit mining operations are discontinued and dewatering ceases. The increase in open-pit metal mining since the 1970s will lead to the formation of numerous pit lakes over the next 50 years. Many of these lakes will develop acid sulfate conditions with high levels of dissolved metals. Approaches to remediation of these conditions that have been recommended include the addition of lime or other alkaline materials and the stimulation of sulfate-reducing bacteria. However, prevention rather than remediation is probably the preferable approach. Measures to prevent oxidation of mining waste and wall rocks, including measures to fill pits quickly with water, to inhibit the activity of acidophilic sulfur-oxidizing bacteria, and to promote anoxic conditions at the lake bottoms may minimize the formation of acids and dissolved metals. (orig.)

2000-10-01

46

Description of Cretaceous Sedimentary Sequence of the Yaojia Formation Recovered by CCSD-SK-Is Borehole in Songliao Basin: Lithostratigraphy, Sedimentary Facies and Cyclic Stratigraphy  

British Library Electronic Table of Contents (United Kingdom)

The Yaojia Formation recovered by CCSD-SK-Is borehole (China Cretaceous Continental Scientific Drilling-SongkeI-the south borehole) is 157.67 m long and 99.96% of cores recovery. The age of the formation corresponds with a range from the Santonian to the early Campanian. The sequences and processes of lithology-lithofacies and cyclic stratigraphy are revealed by a detailed core description. Eleven rock types and three kinds of sedimentary subfacies, including shallow lake, deep lake, and delta front, are recognized from the drilling core. There are eleven sedimentary microfacies including dolostone, argillaceous limestone, shallow lake turbidite, deep lake turbidite, subaqueous mouth bar, distal bar, sheet sandstone, subaqueous distributary bay, slump deposits, shallow lake mudstone, and d...

2009-01-01

47

The use of oxygen isotopic composition to study water dynamics in Amazon floodplain lakes  

International Nuclear Information System (INIS)

The lakes formed in the Amazon floodplain play a key role in sustaining the highest populational density in the Amazon Basin because of its high primary productivity. The water volume in these lakes vary greatly during the year and possible water sources are the feeding river during high water state of the hydrographs and local inputs from its drainage basin. As these sources are chemically distinct, to understand the nutrient dynamics in these lakes, it is very important to know the relative water contribution of different water sources. In this paper we use "1"8O as a conservative to know the water sources for the lakes and our hypothesis is that: 1) In the high water stage lake water is derived predominantly from its feeding river. Therefore their #delta#"1"8O should be similar. 2) In the low water stage lake water is a mixture of watershed and last flood ...

1989-05-01

48

Kokanee Stocking and Monitoring, Flathead Lake, 1993-1994 Annual Report.  

Energy Technology Data Exchange (ETDEWEB)

One mitigation goal of the Hungry Horse Dam fisheries mitigation program, funded by the Bonneville Power Administration, is to replace lost production of 100,000 adult kokanee in Flathead Lake. The mitigation program calls for a five-year test to determine if kokanee can be reestablished in Flathead Lake. The test consists. of annual stocking of one million hatchery-raised yearling kokanee. There are three benchmarks for judging the success of the kokanee reintroduction effort: (1) Post-stocking survival of 30 percent of planted kokanee one year after stocking; (2) Yearling to adult survival of 10 percent (100,000 adult salmon); (3) Annual kokanee harvest of 50,000 or more fish per year by 1998, with an average length of 11 inches or longer for harvested fish, and fishing pressure of 100,000 angler hours or more. Kokanee were the primary sport fish species in the Flathead Lake fishery in the early 1900s, and up until the ...

1995-07-01

49

Description of Cretaceous Sedimentary Sequence of the Second and Third Member of the Qingshankou Formation Recovered by CCSD-SK-Is Borehole in Songliao Basin: Lithostratigraphy, Sedimentary Facies and Cyclic Stratigraphy  

British Library Electronic Table of Contents (United Kingdom)

The second and third member of the Qingshankou Formation recovered by CCSD-SK-Is borehole (China Cretaceous Continental Scientific Drilling-SongkeI-the south borehole) is 415.61 m long and 100% of cores recovery. The age of the member corresponds approximately to the Coniacian. The sequence and process of lithology-lithofacies and cyclic stratigraphy were revealed by a detailed core description. 12 rock types and 2 kinds of sedimentary subfacies including semi-deep lake and shallow lake were recognized from the drilling core of the second and third member of the Qingshankou Formation. 10 sedimentary microfacies are present, including dolomite, marl, limestone, oil shale, semi-deep lake turbidite, volcanic ash, seismite, semi-deep lake mudstone, shallow lake mudstone, and shallow lake turbi...

2009-01-01

50

The Wilsonville Advanced Coal Liquefaction Research and Development Facility, Wilsonville, Alabama  

Energy Technology Data Exchange (ETDEWEB)

This report presents the operating results for Run 255 at the Advanced Coal Liquefaction Research and Development Facility in Wilsonville, Alabama. This run operated in the Close Coupled Integrated Two-Stage Liquefaction mode (CC-ITSL) using Martin Lake Texas lignite. The purpose of this run was to demonstrate unit and system operability with Martin Lake lignite. Run 255 began on 20 March 1988 and continued through 9 June 1988. During this period, 204.4 MF tons of Martin Lake Texas lignite were fed in 1865.5 hours of operation. 70 figs., 21 tabs.

1991-05-01

51

Metabolic stress-like condition can be induced by prolonged strenuous exercise in athletes  

UK PubMed Central (United Kingdom)

Few studies have examined energy metabolism during prolonged, strenuous exercise. We wanted therefore to investigate energy metabolic consequences of a prolonged period of continuous strenuous work...Full Text Available

2009-03-01

52

Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis  

UK PubMed Central (United Kingdom)

AMP-activated-protein-kinase (AMPK) is a key sensor and regulator of cellular and whole-body energy metabolism and plays a key role in regulation of lipid metabolism. Since lipid metabolism...Full Text Available

2010-09-03

53

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells  

UK PubMed Central (United Kingdom)

13C metabolic flux analysis (MFA) is the most comprehensive means of characterizing cellular metabolic states. Uniquely labeled isotopic tracers enable more focused analyses to probe...Full Text Available

2009-11-01

54

Detecting variants with Metabolic Design, a new software tool to design probes for explorative functional DNA microarray development  

UK PubMed Central (United Kingdom)

BackgroundMicroorganisms display vast diversity, and each one has its own set of genes, cell components and metabolic reactions. To assess their huge unexploited metabolic potential...Full Text Available

55

ppsx Document (8686k)  

Science.gov (United States)

Slide 10 Slide 11 23 ground-floor apartments Ancillary Information Gathered Median total PAH [mg/g] Slide 15 What are the principal sources of PAHs to urban lakes?...

2010-11-23

56

U.S. Fish and Wildlife Service Home  

Science.gov (United States)

Lake Unit AL-05P, for public review and comment. These four CBRS units are located in Baldwin and Mobile Counties, Alabama. We invite the public to review and comment on the draft...

2011-09-14

57

Stream, lake, estuary, and ocean pollution, 2nd edition  

Energy Technology Data Exchange (ETDEWEB)

This book, an updated version of the 1985 edition, contains thirteen chapters, beginning with a preface which provides the objective of the book. The primary objective is to offer a comprehensive survey of the biological, hydrological, mathematical, and biochemical aspects of stream, lake, estuary, and ocean pollution analysis. The book also contains ten appendices of useful tables and nomographs of pertinent data. This book provides a very good summary and review of stream, lake, estuary, and ocean pollution. This book is recommended for environmental engineering students, environmental consulting engineers, and regulatory personnel. It provides an excellent summary of the field of stream and lake analysis and modeling. Every chapter includes a significant number of questions and pertinent references.

1991-01-01

58

Salt Lake City shows hot and cold spots - NASA ... - Science@NASA  

Science.gov (United States)

Jul 21, 1998 ... Additional roof surface temperatures were taken with a handheld "heat spy," an infrared thermometer to help calibrate the ATLAS thermal ...

59

Rio Negro Floodplain, Patagonia, Argentina - NASA Earth Observatory  

Science.gov (United States)

Feb 15, 2010 ... This astronaut photo from January 4, 2010, shows meander scars and oxbow lakes in the floodplain of the Rio Negro in South America.

60

Myxoviruses Monitoring in Seals Populations  

International Science & Technology Center (ISTC)

Comparative Molecular Genetic Monitoring of Myxoviruses Circulating in Populations of Seals Phoca Caspia and Phoca Sibirica in Northern Caspian Region and Lake Baikal

61

Human Interfaces for Robotic Satellite Servicing  

Science.gov (United States)

... of China Lake Naval Weapons Center, California. ... Figure 4: The Space-Based Laser cleaning ... of Aeronautics and Astronautics (AIAA) Space 2001 ...

2011-05-13

62

Global Change Master Directory (GCMD) - NASA  

Science.gov (United States)

The fields in this dataset are: Date Lake Depth Dissolved Organic Carbon Dissolved carbohydrates and amino acids Inorganic Nutrient Concentrations Primary ...

63

Exxon Valdez oil spill. State/federal natural resource damage assessment final report. Sockeye salmon overescapement. Fish/shellfish study number 27  

Energy Technology Data Exchange (ETDEWEB)

The authors examined the effects of large escapements of sockeye salmon in to the Kenai River and into Red and Akalura Lakes on Kodiak Island. Estimated smolt numbers outmigrating from the Kenai River decreased from 30 million in 1989 to under 500,000 in 1992. Decreased overwintering survival of age-0 juvenile sockeye salmon rearing in Skilak and Kenai lakes is the major contributor to this decline. Preliminary examination of limnological data from Skilak and Kenai Lakes provided no obvious explanation for this major decline in winter survival of juvenile sockeye. Due to differences in diel vertical migration of zooplankton among glacial lakes on the Kenai Peninsula with varying planktivores levels, the authors hypothesize that behavioral changes of zooplankton induced by predation may be a major contributor to the juvenile sockeye decline.

1993-07-01

64

Environmental Assessment | Science & Technology | US EPA  

Science.gov (United States)

Report) A Screening Assessment of the Potential Impacts of Climate Change on Combined Sewer Overflow (CSO) Mitigation in the Great Lakes and New England Regions (Final Report)...

2011-09-30

65

Do Dreissenid Mussels Affect Lake Erie Ecosystem Stability Processes?  

Science.gov (United States)

... associated with non-reporting of phosphorus input from combined sewer overflow discharge all could potentially play a part in ... ...

66

Characterizing partial upwellings ... - Lake Tahoe Validation - NASA  

Science.gov (United States)

measure meteorological variables and bulk water temper- ature. The locations of the buoys are given in Table 1. TB2 and TB3 were moved slightly farther south ...

67

Analyses and monitoring of lignite mining lakes in Eastern Germany with spectral signatures of Landsat TM satellite data  

British Library Electronic Table of Contents (United Kingdom)

Coal mining activities cause an increased acidity and an associated decrease of the pH-value in mine waters. This process is also known as acid mine drainage (AMD). Due to AMD, lakes that were formed in the post mining landscapes in the lignite mining area of Central Germany are characterized by specific limnological development changes. Remote sensing is a time and cost saving technique that enables the observation of the hydrological and limnological development of the lakes ranging from a small to a mid size scale. The current research was based on Landsat TM5/ETM+7 satellite data collected between 1999 and 2004. In combination of satellite data, surface waters of the post mining lakes in Central Germany were sampled and analyzed for their physicochemical properties. The objective of th...

2011-01-01

68

The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism  

DEFF Research Database (Denmark)

Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis. Mitochondrial dysfunction has been linked to genomic instability, and it is possible that the limiting effect of mitochondrial dysfunction on the levels of nucleotides and resulting aberrant RNA and DNA synthesis in part can be responsible for this link. This paper summarizes the parts of the metabolic pathways responsible for nucleotide metabolism that can be affected by mitochondrial dysfunction.

2010-01-01

69

The role of fatty acid desaturases in epidermal metabolism  

UK PubMed Central (United Kingdom)

The lipid composition of skin is important to a variety of functions served by this organ. Therefore, skin expresses multiple enzymes that synthesize and metabolize lipids. An important class of lipid...Full Text Available

2011-04-01

70

Salicylate Metabolism in Twins  

UK PubMed Central (United Kingdom)

To evaluate the contribution of genetic influences on the individual variation in plateau serum salicylate levels, salicylate metabolism was studied in seven pairs of identical and six pairs of fraternal...Full Text Available

1977-07-01

71

Dysregulation of the mevalonate pathway promotes transformation  

UK PubMed Central (United Kingdom)

The importance of cancer metabolism has been appreciated for many years, but the intricacies of how metabolic pathways interconnect with oncogenic signaling are not fully understood. With a clear understanding...Full Text Available

2010-08-24

72

Cancer as a metabolic disease  

UK PubMed Central (United Kingdom)

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which...Full Text Available

73

The Phenomics and Expression Quantitative Trait Locus Mapping of Brain Transcriptomes Regulating Adaptive Divergence in Lake Whitefish Species Pairs (Coregonus sp.)  

UK PubMed Central (United Kingdom)

We used microarrays and a previously established linkage map to localize the genetic determinants of brain gene expression for a backcross family of lake whitefish species pairs (Coregonus sp.). Our...Full Text Available

2008-09-01

74

50 CFR 17.96 - Critical habitat-plants.  

Science.gov (United States)

...ER14AU08.000 (6) Unit 2: North Baldwin Meadow, San Bernardino County, California...and ARUR 12. Gold Mountain and North Baldwin Lake, San Bernardino County, California...ER26DE07.007(13) Unit ARUR 15. South Baldwin Ridge/Erwin Lake, San Bernardino...

2010-10-01

75

Analytical surveys on water quality of Trasimeno Lake: Definition of trophic levels; Indagine sulla qualita` delle acque del Lago Trasimeno: Definizione dei livelli trofici  

Energy Technology Data Exchange (ETDEWEB)

The previous judgment of eutrophic state, once proposed for the Trasimeno Lake (Umbria region, Italy), has been revised. According to Vollenweider-OECD classification criterion, the lake waters are at present to be classified as mesotrophic waters, with phosphorus limitation. However this level of moderate productivity results to be conditioned by the hydrochemical characteristics of the lake waters, that control phosphorus concentrations independently from the loading coming from the basin, and prevent dangerous and massive algal blooms. Different processes of chemical nature, regulating the phosphorus amount in the lake waters, are then reviewed: adsorption of P/P0(4) onto suspended materials, particularly clay mineral particles, and direct precipitation as hydroxylapatite or co-precipitation with carbonates, are found to be the principal mechanisms that determine chemical removal of phosphorus from ...

1995-06-01

86

Coastal metabolism and the oceanic organic carbon balance  

Energy Technology Data Exchange (ETDEWEB)

The metabolism of organic matter in the coastal regions of the ocean may significantly affect the oceanic carbon budget. This paper describes the high percentage (30%) of oceanic oxidation that occurs in coastal areas and the impact of this metabolism on the carbon cycle and climate of earth. Organic metabolism in the ocean appears to be a source of carbon dioxide release into the atmosphere. Oxidation in the coastal zone is of special interest, as it is likely influenced by anthropogenic activity. Recommendations for future research on this topic are proposed. 129 refs., 2 figs., 6 tabs.

1993-02-01

89
90

Water resources data for Minnesota, water year 1993. Volume 2. Upper Mississippi and Missouri River basins. Water-data report (Annual), 1 October 1992-30 September 1993  

Energy Technology Data Exchange (ETDEWEB)

Water-resources data for the 1993 water year for Minnesota consists of records of stage, discharge and water quality of streams; stage, contents, and water quality of lakes and reservoirs; and water levels and water quality in wells and springs. This volume contains discharge records for 58 gaging stations; stage and contents for 9 lakes and reservoirs; water quality 15 stream stations, 1 lakes station, 1 precipitation station, and water levels for 15 observation wells. Also included are 61 high-flow partial-record stations. Additional water data were collected at various sites, not part of the systematic data collection program and are pulished as miscellaneous measurements.

1994-07-01

91

Water resources data for Minnesota, water year 1991. Volume 2. Upper Mississippi and Missouri River Basins. Water-data report (Annual), 1 October 1990-30 September 1991  

Energy Technology Data Exchange (ETDEWEB)

Water-resources data for the 1991 water year for Minnesota consist of records of stage, discharge and water quality of streams; stage, contents, and water quality of lakes and reservoirs; and water levels and water quality in wells and springs. The volume contains discharge records for 60 gaging stations; stage and contents for 9 lakes and reservoirs; water quality for 18 stream stations, 1 lake station, 22 partial-record sites, 1 precipitation station, 108 wells; and water levels for 119 observation wells. Also included are 59 high-flow partial-record stations. Additional water data were collected at various sites, not part of the systematic data collection program and are published as miscellaneous measurements or low-flow investigations.

1992-09-01

92

Temporal variations of fluoride concentration in Isparta public water system and health impact assessment (SW-Turkey)  

British Library Electronic Table of Contents (United Kingdom)

Water?rock interaction is one of the prime factors affecting the fluoride contents of surface and groundwater. If fluoride concentration of drinking water has been neglected, excess fluoride can cause serious dental and medical problems on human health, which is well known at Golcuk-Isparta region. In the research area, Egirdir lake, Golcuk lake and surrounding springs have been utilized as drinking water sources. Golcuk lake water and surrounding groundwaters have high fluoride content (1.4?4.6?mg/l), which is above the WHO standards. Fluoride is predominantly supplied by dissolution of fluoride within the fluormicas of volcanics during the circulation of water. Fluoride concentrations of waters have shown variations for dry and rainy seasons depending on the degree of interaction between...

2008-01-01

93

Geochemical History of the Dead Sea  

British Library Electronic Table of Contents (United Kingdom)

Graphical Abstract A Southward view of the Dead Sea western coast. The steep western escarpment of the Dead Sea basin, composed mainly of Upper Cretaceous limestone and dolomite, can be seen on the right. Beach terraces left by the shrinking lake run parallel to the shore. The larger part of the area between the present water line and the mountains was still under Dead Sea water just 50?60?years ago. The current fall of the lake?s stand is around 1?m?year?1. Three on-shore sinkholes can be seen in the front of the photo, as well as two submerged ones near its lower left corner. These were caused by dissolution of a Holocene salt layer located tens of meters below the surface, resulting in the collapse of the overlying sediments. The retreat of the Dead Sea in recent years was followed by e...

2009-01-01

94

A protocol for the evaluation of genotoxicity in bile of carp (Cyprinus carpio) exposed to lake water treated with different disinfectants  

British Library Electronic Table of Contents (United Kingdom)

A sensitive and rapid method to evaluate toxic and genotoxic properties of drinking water supplied from Lake Trasimeno (Umbria, Central Italy) was worked out analysing bile in Cyprinus carpio exposed for 20d to lake water treated with 3 different disinfectants, sodium hypochlorite (NaClO), chlorine dioxide (ClO2) and peracetic acid (PAA). Fish were sacrificed at 0, 10 and 20d in order to investigate the time course of these endpoints. An aliquot of bile samples was fractionated by adsorption on C18 silica cartridges and the genotoxic potential of whole bile and of bile fractions was evaluated by the single-cell microgel-electrophoresis (comet) assay on human colonic adenocarcinoma cells (Caco-2). Bile (both whole and fractionated) from specimens exposed to the three disinfectants always sh...

2011-01-01

95

Sediment trap fluxes and benthic recycling of organic carbon, polycyclic aromatic hydrocarbons, and polychlorobiphenyl congeners in Lake Superior  

Energy Technology Data Exchange (ETDEWEB)

Sediment trap fluxes of solids, organic carbon, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) were measured in Lake Superior in 1984 and 1985. Mass fluxes from surface waters ranged from 0.14 to 1.1 g/m{sup 2}{center dot}day and increased near the lake floor due to resuspension of surficial sediment and horizontal transport in the benthic nepheloid layer. Organic matter fluxes from surface water ranged from 60 to 90 mg of C/m{sup 2}{center dot}day, with {approximately}5% of organic carbon settling from surface waters accumulating in bottom sediments. Concentrations of PCBs and PAHs are enriched 10-100 times on settling particles relative to those on suspended particles. Resultant settling fluxes are 10-100 times greater for several PCB and PAH compounds than net accumulation rates in bottom sediments, indicating the effective and rapid recycling in the benthic region. Biological packaging of organic pollutants ...

1991-03-01

96

Measurement of snow water storage in the Lake Saperior basin using aerial gamma-ray spectrometry  

International Nuclear Information System (INIS)

A pilot project was started in 1977 over the Lake Superior basin to measure water storage on the land area using aerial gamma-ray spectrometry to provide hydrologic information for forecasting inflow to the lake. Two airborne surveys were made, respectively in November 1977 and March 1978 which provided estimates of the increase in snow water equivalent between these surveys. The basin is located on the Canadian Shield and consequently, the gamma radiation count rate is quite variable. The airborne results are compared with ground measurements on selected flight lines and show generally good agreement. Two equipment calibrations in the Ottawa area provided inconsistent parameter values which are consequently also reflected in the results over the Lake Superior basin. The project has demonstrated to-date that the technique can be developed into an operational system for measuring snow cover water equivalent of this vast and ...

1977-11-01

97

Impact of climate change on carbon cycle in freshwater ecosystems  

Energy Technology Data Exchange (ETDEWEB)

The impacts of the expected climate change on Finnish lake ecosystems were studied with the biota of the mesohumic Lake Paeaejaervi, southern Finland. Experimental conditions, from small-scale experiments on single species level to a large-scale ecosystem manipulation, were established to simulate directly the future climate and/or loading of nutrients and dissolved organic matter (DOM) from the drainage area. The experimental studies were accomplished by modelling the carbon flow in the pelagic food web as well as the growth of littoral macrophytes. The main hypothese tested were as follows: As a consequence of the climate change (rising temperature and increasing precipitation) the loading of nutrients and dissolved organic matter (DOM) from the drainage area to the lake will increase. In the pelagic zone this will be first reflected i higher productivity of primary producers and bacteria, but will later affect the entire ...

1996-12-31

98

INVERTEBRATE FAUNA ASSOCIATED WITH TORPEDOGRASS, PANICUM REPENS (CYPERALES: POACEAE), IN LAKE OKEECHOBEE, FLORIDA, AND ...  

Science.gov (United States)

... 154. By way of comparison, the aquatic weed Hygrophila polysperma (Roxb.) T. Anderson, a potential target for biological ... L. Sutton. 2000. Is the aquatic weed hygrophila, Hygrophila polysperma (Polemon...

99

Green Lake Landslide and other giant and very large postglacial landslides in Fiordland, New Zealand  

British Library Electronic Table of Contents (United Kingdom)

Green Lake Landslide is an ancient giant rock slide in gneiss and granodiorite located in the deeply glaciated Fiordland region of New Zealand. The landslide covers an area of 45km2 and has a volume of about 27km3. It is believed to be New Zealands largest landslide, and possibly the largest landslide of its type on Earth. It is one of 39 known very large (106-107 m3) and giant (?108m3) postglacial landslides in Fiordland discussed in the paper. Green Lake Landslide resulted in the collapse of a 9km segment of the southern Hunter Mountains. Slide debris moved up to 2.5km laterally and 700m vertically, and formed a landslide dam about 800m high, impounding a lake about 11km long that was eventually infilled with sediments. Geomorphic evidence supported by radiocarbon dating indicates tha...

2009-01-01

100

Evolution of feeding specialization in Tanganyikan scale-eating cichlids: a molecular phylogenetic approach  

UK PubMed Central (United Kingdom)

BackgroundCichlid fishes in Lake Tanganyika exhibit remarkable diversity in their feeding habits. Among them, seven species in the genus Perissodus are known for...Full Text Available

101

Are causes knowable? Some consequences of successional versus toxicological interpretations of the Great Lakes water quality agreement  

International Nuclear Information System (INIS)

The focus of the present Great Lakes water quality agreement between Canada and the United States is on transboundary pollution and particularly the injury to health and property from exposures to persistent toxic substances. Several scientists and policy advisors have suggested, on the basis of the Ecosystem Approach and systems theory, that the agenda should move on to other demanding topics, such as the introduction of exotic species, biodiversity, habitat restoration, fisheries management, sustainable development, and governance of the Great Lakes basin. None of these issues, however, poses the same scale of threat to national sovereignty and bilateral interests as does transboundary pollution. Thus, none warrants the degree of attention that has been and should be paid, despite declining budgets, to assessing and controlling releases of persistent toxic substances that continue to injure fish, wildlife, and human health. Instead, it is ...

102

Water resources data for Oklahoma, water year 1992. Volume 2. Red River Basin. Water-data report (Annual), 1 October 1991-30 September 1992  

Energy Technology Data Exchange (ETDEWEB)

Volume 2 of the water resources data for the 1992 water year for Oklahoma consists of record of stage, discharge, and water quality of streams; stage, contents, and water quality of lakes or reservoirs; and water levels of ground-water well. The report contains discharge records for 136 gaging stations; stage and contents for 31 lakes or reservoirs; water quality for 50 gaging stations. Also included are 61 partial-record or miscellaneous streamflow stations and 28 ground-water sites.

1993-04-01

103

The Baikal neutrino experiment  

International Nuclear Information System (INIS)

We review the status of the Lake Baikal Neutrino Experiment. Preparation towards a km"3-scale Gigaton Volume Detector (GVD) in Lake Baikal is currently a central activity. As an important milestone, a km"3-prototype string comprising of 12 optical modules and based on a completely new technology, has been installed and was put in operation together with NT200+ in April, 2009. We also present recent results from the long-term operation of NT200, including an improved limit on the diffuse astrophysical neutrino flux.

2011-01-11

104

Effects of variable hardness, ph, alkalinity, suspended clay, and humics on the chemical speciation and aquatic toxicity of copper  

Science.gov (United States)

The effects of variable hardness, pH, alkalinity, humics, and suspended clay on the chemical speciation of copper and its toxicity to fathead minnow larvae in Lake Superior water were investigated. Two proposed methods (toxicity factors and chemical speciation) for predicting LC50 values in specific natural waters from laboratory toxicity data and the average site specific values of general water quality parameters were evaluated. The accuracy of the cupric ion-selective electrode in determining CU/sup +2/ activities in ambient and chemically altered Lake Superior water was also determined.

1986-03-01

105

Aerial gamma ray and magnetic survey, Mississippi and Florida airborne survey: Lake Charles and Port Arthur quadrangles of Louisiana and Texas. Final report  

International Nuclear Information System (INIS)

The Lake Charles and Port Arthur quadrangles cover approximately 10,950 square miles of land west of the Mississippi River delta area. The area overlies thick sections of the Gulf of Mexico Basin. Surficial exposures are dominated by Recent and Pleistocene sediment. A search of available literature revealed no known uranium deposits. A total of 82 uranium anomalies were detected and are discussed briefly in this report. None were considered significant and all appear to relate to cultural features. Magnetic data appear to be in agreement with existing structural interpretations of the area.

106

The metabolism of the isomeric decalones  

UK PubMed Central (United Kingdom)

1. The metabolism of (±)-cis-1-, (±)-trans-1-, (±)-cis-2- and (±)-trans-2-decalone in the rabbit...Full Text Available

1966-08-01

107

The effect of diphenylhydantoin on thyroxine metabolism in man  

UK PubMed Central (United Kingdom)

The effect of 5,5′-diphenylhydantoin on thyroxine metabolism was examined in five normal volunteers. Intravenous injection of radiothyroxine was followed by a 10-12 day control and subsequent...Full Text Available

1970-06-01

108

The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN study*  

UK PubMed Central (United Kingdom)

Chronically elevated interleukin-6 (IL-6) affects lipid and lipoprotein metabolism. Individuals genetically predisposed to higher IL-6 secretion may be at risk of dyslipidemia, especially during the...Full Text Available

2008-08-01

109

The Metabolism of the Germinating Oil Palm (Elaeis guineensis) Seedling 1  

UK PubMed Central (United Kingdom)

The metabolism of 14C-labeled fatty acids and triacylglycerols was followed in intact germinating oil palm seedlings as well as in tissue slices. In the germinating seedling, the shoot contained...Full Text Available

1983-12-01

110

The Long-Term Effects of Prematurity and Intrauterine Growth Restriction on Cardiovascular, Renal, and Metabolic Function  

UK PubMed Central (United Kingdom)

Objective. To determine relative influences of intrauterine growth restriction (IUGR) and preterm birth on risks of cardiovascular, renal, or metabolic dysfunction in adolescent...Full Text Available

2010-01-01

111

The Heparan and Heparin Metabolism Pathway is Involved in Regulation of Fatty Acid Composition  

UK PubMed Central (United Kingdom)

Six genes involved in the heparan sulfate and heparin metabolism pathway, DSEL (dermatan sulfate epimerase-like), EXTL1 (exostoses (multiple)-like 1), HS6ST1...Full Text Available

112

SirT3 suppresses hypoxia inducible factor 1? and tumor growth by inhibiting mitochondrial ROS production  

UK PubMed Central (United Kingdom)

It has become increasing clear that alterations in cellular metabolism have a key role in the generation and maintenance of cancer. Some of the metabolic changes can be attributed to the activation...Full Text Available

2011-06-30

113

Prevention of cardiovascular disease: Obesity, diabetes and the metabolic syndrome  

UK PubMed Central (United Kingdom)

The current obesity pandemic is expected to result in considerable downstream morbidity, mortality and incremental costs to health care systems around the world. The major metabolic complications of...Full Text Available

2010-08-01

114

Polyamine Metabolism in Ripening Tomato Fruit 1  

UK PubMed Central (United Kingdom)

The metabolism of [1,4-14C]putrescine and [terminal methylene-3H]spermidine was studied in the fruit pericarp (breaker stage) discs of tomato (Lycopersicon esculentum...Full Text Available

1990-11-01

115

Pathophysiological, Genetic and Gene Expression Features of a Novel Rodent Model of the Cardio-Metabolic Syndrome  

UK PubMed Central (United Kingdom)

BackgroundComplex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models.Methodology/Principal...Full Text Available

116

PDP-1 Links the TGF-? and IIS Pathways to Regulate Longevity, Development, and Metabolism  

UK PubMed Central (United Kingdom)

The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1...Full Text Available

2011-04-01

117

Metabolism of Cytokinin  

UK PubMed Central (United Kingdom)

As part of the study of cytokinin metabolic pathways, an enzyme, adenosine phosphorylase (EC 2.4.2.-), which catalyzed the ribosylation of N6-(Δ2-isopentenyl)adenine,...Full Text Available

1978-12-01

118

Metabolic syndrome in subjects with type-2 diabetes mellitus.  

UK PubMed Central (United Kingdom)

BACKGROUND: Each component of metabolic syndrome (MS) conveys increased cardiovascular disease risk, but as a combination they become much more powerful. Vigorous early management of the syndrome may...Full Text Available

2004-06-01

119

Metabolic labeling and direct imaging of choline phospholipids in vivo  

UK PubMed Central (United Kingdom)

Choline (Cho)-containing phospholipids are the most abundant phospholipids in cellular membranes and play fundamental structural as well as regulatory roles in cell metabolism and signaling. Although...Full Text Available

2009-09-08

120

Metabolic clearance of biologically active luteinizing hormone in man.  

UK PubMed Central (United Kingdom)

The plasma metabolic clearance of biologically active luteinizing hormone (bioactive LH) was studied using the rat interstitial cell testosterone (RICT) bioassay in six hypogonadotropic men after single...Full Text Available

1986-04-01

121

Malolactic fermentation: electrogenic malate uptake and malate/lactate antiport generate metabolic energy.  

UK PubMed Central (United Kingdom)

The mechanism of metabolic energy production by malolactic fermentation in Lactococcus lactis has been investigated. In the presence of L-malate, a proton motive force composed of a membrane potential...Full Text Available

1991-10-01

122

METABOLIC REGULATION OF ADENOSINE TRIPHOSPHATE SULFURYLASE IN YEAST  

UK PubMed Central (United Kingdom)

de Vito, Peter C. (Princeton University, Princeton, N.J.), and Jacques Dreyfuss. Metabolic regulation of adenosine triphosphate sulfurylase in yeast. J. Bacteriol. 88:1341–1348....Full Text Available

1964-11-01

123

Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages?  

UK PubMed Central (United Kingdom)

Host cells use metabolic signaling through the LXRα nuclear receptor to defend against Listeria monocytogenes infection. 25-Hydroxycholesterol is a natural ligand of LXRs that...Full Text Available

2011-04-01

124

Juvenile salmon with high standard metabolic rates have higher energy costs but can process meals faster  

UK PubMed Central (United Kingdom)

Basal or standard metabolic rate (SMR) has been found to exhibit substantial intraspecific variation in a range of taxa, but the consequences of this variation are little understood. Here we explore...Full Text Available

2009-06-07

125

Influence of obesity on the metabolism of apolipoprotein B in humans.  

UK PubMed Central (United Kingdom)

The influence of obesity on the metabolism of apolipoprotein B (apo B) in very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and low density lipoprotein (LDL) was investigated...Full Text Available

1985-08-01

126

Impact of the Metabolic Syndrome on the Clinical Outcome of Patients with Acute ST-Elevation Myocardial Infarction  

UK PubMed Central (United Kingdom)

We sought to determine the prevalence of metabolic syndrome (MS) in patients with acute myocardial infarction and its effect on clinical outcomes. Employing data from the Korea Acute Myocardial Infarction...Full Text Available

2010-10-01

127

Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors  

UK PubMed Central (United Kingdom)

Histamine has been proposed to be an important regulator of energy intake and expenditure. The aim of this study was to evaluate histamine regulation of glucose and lipid metabolism and development...Full Text Available

2010-08-01

128

Functional significance of UDP-glucuronosyltransferase (UGT) variants in the metabolism of active tamoxifen metabolites  

UK PubMed Central (United Kingdom)

Tamoxifen (TAM) is a selective estrogen receptor modulator widely used in the prevention and treatment of breast cancer. A major mode of metabolism of the major active metabolites of TAM, 4-OH-TAM...Full Text Available

2009-03-01

129

Functional Exoenzymes as Indicators of Metabolically Active Bacteria in 124,000-Year-Old Sapropel Layers of the Eastern Mediterranean Sea  

UK PubMed Central (United Kingdom)

Hydrolytic exoenzymes as indicators of metabolically active bacteria were investigated in four consecutive sapropel layers collected from bathyal sediments of the eastern Mediterranean Sea. For comparison,...Full Text Available

2000-06-01

130

Energy metabolism of the untrained muscle of elite runners as observed by 31P magnetic resonance spectroscopy: evidence suggesting a genetic endowment for endurance exercise.  

UK PubMed Central (United Kingdom)

The purpose of this study was to investigate whether genetically determined properties of muscle metabolism contribute to the exceptional physical endurance of world-class distance runners. ATP, phosphocreatine,...Full Text Available

1988-12-01

131

Effects of Essential Oils on Ruminal Microorganisms and Their Protein Metabolism  

UK PubMed Central (United Kingdom)

A commercial blend of essential oil (EO) compounds was added to a grass, maize silage, and concentrate diet fed to dairy cattle in order to determine their influence on protein metabolism by ruminal...Full Text Available

2003-08-01

132

Effect of naproxen on glucose metabolism and tolbutamide kinetics and dynamics in maturity onset diabetics.  

UK PubMed Central (United Kingdom)

1 The influence of the nonsteroidal anti-inflammatory drug naproxen on glucose metabolism and on tolbutamide pharmacokinetics and pharmacodynamics has been studied in ten maturity-onset diabetics. 2...Full Text Available

1981-03-01

133

Do insect metabolic rates at rest and during flight scale with body mass?  

UK PubMed Central (United Kingdom)

Energetically costly behaviours, such as flight, push physiological systems to their limits requiring metabolic rates (MR) that are highly elevated above the resting MR (RMR). Both RMR and MR during...Full Text Available

2005-09-22

134

Disturbance of inorganic phosphate metabolism in diabetes mellitus: temporary therapeutic intervention trials  

UK PubMed Central (United Kingdom)

A paradoxical metabolic imbalance in inorganic phosphate occurs from the early onset of diabetes and may lead to a reduction of high energy phosphates and tissue hypoxia. These changes take place in...Full Text Available

135

Calcium Requirements and Metabolism in Chinese-American Boys and Girls  

UK PubMed Central (United Kingdom)

Calcium requirements of North American adolescents were set at 1300 mg/day based on data from white girls. Calcium requirements for Asian-American adolescents have not been studied. Using metabolic...Full Text Available

2010-08-01

136

Association of mineral composition of neonatal intravenous feeding solutions and metabolic bone disease of prematurity.  

UK PubMed Central (United Kingdom)

To assess the effects of increasing the mineral content of parenteral nutrition solutions on the biochemical and radiological indicators of metabolic bone disease of prematurity 27 neonates who required...Full Text Available

1989-04-01

137

Association of Paraoxonase 1 (PON1) polymorphisms with osteoporotic fracture risk in postmenopausal Korean women  

UK PubMed Central (United Kingdom)

There is increasing evidence of a biochemical link between lipid oxidation and bone metabolism. Paraoxonase 1 (PON1) prevents the oxidation of low-density lipoprotein (LDL) and metabolizes biologically...Full Text Available

2011-02-28

138

Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography  

UK PubMed Central (United Kingdom)

BackgroundIn vitro data suggest that changes in myocardial substrate metabolism may contribute to impaired myocardial function in diabetic cardiomyopathy (DCM)....Full Text Available

139

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats  

UK PubMed Central (United Kingdom)

The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity. Apart from its role as ...Full Text Available

140

Abscisic Acid Alters the Metabolism of Indole-3-Acetic Acid in Senescing Flowers of Cucumis melo L  

UK PubMed Central (United Kingdom)

Experiments were conducted to investigate indole-3-acetic acid (IAA) and abscisic acid (ABA) metabolism associated with postanthesis senescence of ovaries from nonpollinated muskmelon (Cucumis...Full Text Available

1990-11-01

141

AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model  

UK PubMed Central (United Kingdom)

BackgroundObesity is one of the principal causative factors involved in the development of metabolic syndrome. AMP-activated protein kinase (AMPK) is an energy sensor that regulates...Full Text Available

142

A Review of the Biochemistry, Metabolism and Clinical Benefits of Thiamin(e) and Its Derivatives  

UK PubMed Central (United Kingdom)

Thiamin(e), also known as vitamin B1, is now known to play a fundamental role in energy metabolism. Its discovery followed from the original early research on the ‘anti-beriberi factor’...Full Text Available

2006-03-01

143

A Double Blind, Placebo-Controlled, Randomized Crossover Study of the Acute Metabolic Effects of Olanzapine in Healthy Volunteers  

UK PubMed Central (United Kingdom)

Background and RationaleAtypical antipsychotics exhibit metabolic side effects including diabetes mellitus and obesity. The adverse events are preceded by acute worsening of oral...Full Text Available

144

A Comparison of the Metabolic Fate of Fatty Acids of Different Chain Lengths in Developing Oilseeds  

UK PubMed Central (United Kingdom)

To determine if medium and long chain fatty acids can be appropriately metabolized by species that normally produce 16 and 18 carbon fatty acids, homogenates of developing Cuphea wrightii, Carthamus...Full Text Available

1989-07-01

145

jahresbericht6.5NEU  

Wastenet

The industrial revolution changed the pattern of human interaction with nature profoundly.Not only did social metabolism

151

Hydrogen, Oxygen, and Carbon Isotope Ratios of Cellulose from Submerged Aquatic Crassulacean Acid Metabolism and Non-Crassulacean Acid Metabolism Plants  

UK PubMed Central (United Kingdom)

Isotope ratios of cellulose and cellulose nitrate from aquatic Crassulacean acid metabolism (CAM) and non-CAM plants were determined. Cellulose oxygen istope ratios for all plants that grew together...Full Text Available

1984-09-01

152

Depression, coronary artery disease, type 2 diabetes, metabolic syndrome and quality of life in Taiwanese adults from a cardiovascular department of a major hospital in Southern Taiwan  

British Library Electronic Table of Contents (United Kingdom)

Aims.- To examine the relationships between depression, coronary artery disease, type 2 diabetes, metabolic syndrome and quality of life in Taiwanese adults from a cardiovascular department of a major hospital in Taiwan. Background.- Research suggests associations between depression, metabolic syndrome and quality of life. Despite this fact, few studies have investigated these relationships among Taiwanese. Design.- A cross-sectional descriptive correlational design was used to conduct this study. Methods.- A convenience sample of 140 adults participated in the study. Data were analysed with descriptive statistics, Pearson-s correlations, hierarchical regression and t-tests. Results.- Almost a half of the subjects (465%) had metabolic syndrome. The most common combination of metabolic synd...

2011-01-01

153

Lower Flathead System Fisheries Study, Executive Summary, Volume I, 1983-1987 Final Report.  

Energy Technology Data Exchange (ETDEWEB)

This Executive Summary, Volume I, of the lower Flathead System Fisheries Study Final Report, was prepared to provide a study overview for persons who are not fisheries scientists. The contents provide an introduction to the study and its objectives, a short description of the study area, a discussion of the major findings and conclusions of the study, and the description of fisheries management alternatives available to managers of the lower Flathead system. Technical reports were prepared for those portions of the study dealing with the lower Flathead River and its tributaries, Volume II, and the South Bay of Flathead Lake, Volume III. The annual hydrographic regime of the Flathead system, consisting of upper rivers, lake and lower river, has been modified by the construction and operation of two major hydroelectric facilities, Hungry Horse Dam on the south fork Flathead River and Kerr Dam at the outlet of Flathead Lake. ...

1988-06-01

154

Global climate change response program. Part 1. Potential effects of global change on chlorophyll alpha concentrations in a southwestern desert reservoir: Las Vegas Bay, Lake Mead, Nevada. Part 2. Simulated impacts of a double CO2 climate on the location of the thermocline in Lake Mead, Nevada. Final report  

Energy Technology Data Exchange (ETDEWEB)

Three algal bioassay experiments were conducted from March 1992 through September 1993 in an area of Lake Mead that has experienced problems associated with severe nutrient enrichment. The first experiment determined the effects of elevated CO2 (700 ppm) (2xCO2), vs ambient CO2 on the natural algal assemblage without nutrient enrichment. The second experiment determined the effects of 2xCO2 on nutrient enriched bioassays and if nutrients were limiting. The third experiment examined elevated temperatures and 2xCO2. Nested climate models were used to predict changes in water temperatures and thermocline development in Las Vegas Bay. The lake model predicted an increase in mean water temperatures of 1.8 deg under a 2xCO2 scenario. A thermocline definition of 1 deg. C change per 2-m depth was applied to water temperatures developed by a lake model coupled to nested general circulation and regional-scale atmospheric models in ...

1997-01-01

155

Fluxes of methane and nitrogen oxides in various boreal mire ecosystems. Effects of land-use activities and environmental changes  

Energy Technology Data Exchange (ETDEWEB)

Atmospheric impact of peatlands is a sum of their gas fluxes. In contrast to carbon dioxide, peatlands are net sources for methane (CH{sub 4}). Methane is an end product in the anaerobic decomposition processes and it has greater capacity to absorb infrared radiation than carbon dioxide. Most of the data on the CH{sub 4} release from northern peatlands is from North America. The total amount of methane released from wetlands is calculated to be 110 Tg yr{sup -1} of which 34 percent (38 Tg yr{sup -1}) is estimated to be emitted from the northern peatlands. Peat with high content of nitrogen is a potential source for gaseous nitrogen oxides, i.e. nitrous oxide (N{sub 2}O) and nitric oxide (NO). However, the importance of peatlands in producing these trace gases is poorly known. Nitrous oxide and nitric oxide are important components in the atmospheric chemistry and N{sub 2}O also is an effective greenhouse gas. Land-use activities and environmental changes can affect the atmospheric ...

1996-12-31

156

Volatile halocarbons as tracers of pulp mill effluent plumes  

Energy Technology Data Exchange (ETDEWEB)

This work describes the use of volatile halocarbons in a pulp mill effluent, including chloroform, bromodichloromethane, and tri- and tetrachloroethylene, as tracers for the distribution and movements of effluent currents in a receiving water bay (Jackfish Bay) on the northern shore of Lake Superior. The results indicate the simplicity and usefulness of the technique and the significantly improved resolution of effluent plume delineation over the customary use of conductance profiles. Concentration patterns of the effluent volatiles suggest counterclockwise circulation of bay water that mixes with inflowing lake water at the eastern reach of the outer bay. The distribution of volatile contaminants is governed by the thermal regime of the receiving waters. During the summer months, the effluent plume wedges between the thermocline and epilimnion, mixing into the surface waters as the distance from the input source increases. In the fall, the ...

1994-07-01

157

Use of lanthanide shift reagents with [sup 31]P FT-NMR spectroscopy to analyze concentrated lake-water samples  

Energy Technology Data Exchange (ETDEWEB)

Several lanthanide shift reagents (LSR) were synthesized from praseodymium, europium, dysprosium, and terbium using ethylenediaminetetraacetic acid, trans-1,2-diaminocyclohexane-N,N,N[prime],N[prime]-tetraacetic acid, and diethylenetriaminepentaacetic acid for the purpose of separating overlapping [sup 31]P FT-NMR spectral signals of dissolved organic phosphorus compounds present in concentrated lake-water samples. The extent of change in signal position and line width of several known phosphorus compounds dissolved in pure water was examined as a function of solution pH and the molar ratio of LSR to phosphorus. Praseodymium ethylenediaminetetraacetate (PrEDTA) was determined to be the most effective LSR. Concentrated lake-water samples mixed with PrEDTA were examined with [sup 31]P FT-NMR. The use of PrEDTA provided separation of overlapping signals, indicated that phosphorus compounds were becoming isolated from the solution environment ...

1994-08-01

158

Chemometric source identification of PCDD/Fs and other POPs in sediment cores of North-East Germany  

Energy Technology Data Exchange (ETDEWEB)

A broad range of persistent organic pollutants (POPs) and selected heavy metals has been analysed in sediment cores of North-East Germany. The pollutants analysed include polychlorinated dioxins and furans (PCDD/Fs), polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), several pesticides (DDT, HCH, CBz) and its metabolites as well as selected heavy metals. The sediment cores were sampled at five locations, reflecting a range of anthropogenic influences and background contamination: Arkona Basin (AK) representing a remote marine site, Lake Bugsin (BS) a background location only with atmospheric deposition, Lake Quenz (QS) close to the industrial city of Brandenburg, Teltowkanal (TK) in the suburban-industrial zone of Berlin and Lake White (WS) in the centre of Berlin. The age of the lower part of the AK, BS and TK cores were dated at 100-150 years. Results of selected pollutants (PCDD/Fs) have been ...

2004-09-15

159

Anomalous carbon isotope fractionation between atmospheric CO/sub 2/ and dissolved inorganic carbon induced by intense photosynthesis  

Energy Technology Data Exchange (ETDEWEB)

A stable isotope mass-balance of dissolved inorganic carbon during a blue-green algae bloom in a softwater lake demonstrates that at low partial pressure of carbon dioxide there must be a large net negative carbon isotope fractionation between atmospheric CO/sub 2/ and the CO/sub 2/ absorbed by lake water at pH = 9.5. Chemical enhancement of CO/sub 2/ invasion at high pH by the reaction CO/sub 2/ + OH/sup -/ ..-->.. HCO/sub 3//sup -/ at large apparent film thicknesses may result in carbon isotope fractionation approaching that for a hydroxide solution. This phenomenon, coupled with a decrease in the photosynthetic fractionation, forced the surface water of a softwater lake to achieve increasingly negative delta /sup 13/C values during an algal bloom, which is in the opposite sense to the trend that results from photosynthesis under less extreme conditions. This and other similar systems must operate under non-equilibrium ...

1987-04-01

160

Bidirectional reaction steps in metabolic networks: II. Flux estimation and statistical analysis.  

Science.gov (United States)

Metabolic carbon labelling experiments enable a large amount of extracellular fluxes and intracellular carbon isotope enrichments to be measured. Since the relation between the measured quantities and the unknown intracellular metabolic fluxes is given by bilinear balance equations, flux determination from this data set requires the numerical solution of a nonlinear inverse problem. To this end, a general algorithm for flux estimation from metabolic carbon labelling experiments based on the least squares approach is developed in this contribution and complemented by appropriate tools for statistical analysis. The linearization technique usually applied for the computation of nonlinear confidence regions is shown to be inappropriate in the case of large exchange fluxes. For this reason a sophisticated compactification transformation technique for nonlinear statistical analysis is developed. Statistical analysis is then ...

1997-07-01

161

{sup 222}Rn as indicator of atmospheric turbulence: measurements at Lake Maggiore and on the pre-Alps  

Energy Technology Data Exchange (ETDEWEB)

Radon concentration measurements in atmosphere were taken in years from 1997 to 1999 in Milan and at pre-alpine sites located north of Lombardy. In this paper the results of measuring campaigns and a comparison of radon levels observed in the hilly area north of the town and on the pre-Alps are reported. The general criteria of the measurements and the interpretative models of radon concentration are presented. The Lake Maggiore area shows evidence of a great nocturnal stability and frequent formation of Nocturnal Stable Layer. The peculiar findings in the high altitude stations confirm the use of radon as an indicator of atmospheric dispersion of pollutants in an area with complex orography. The afternoon minimum values are concordant for the different stations: this implies a remixing in afternoon hours over the whole area investigated.

2006-07-01

162

Simulation on stream flow and nutrient loadings in Gucheng Lake, Low Yangtze River Basin, based on SWAT model  

British Library Electronic Table of Contents (United Kingdom)

A distributed watershed hydrologic model soil and water assessment tool (SWAT, 2000 Version) was applied to simulate stream flow and nutrient loadings (including total nitrogen (TN) and total phosphorus (TP)) in Gucheng Lake Basin, which is located in the lower reach of Yangtze River Basin. Model parameters related to stream flow and nutrient loadings were calibrated and validated by the observed value, and the simulation showed that the simulated values were reasonably comparable to the observed data, suggesting the validity of SWAT model. The simulated surface runoff and nutrient yield between two stages, viz. 1981-2000 and 1951-1960, were compared, basically considering land reclamation in the mid-1970s. The result indicated that, the average annual runoff and output of TN and TP in 198...

2009-01-01

163

Selenium Concentrations in Greater Scaup and Dreissenid Mussels During Winter on Western Lake Ontario  

British Library Electronic Table of Contents (United Kingdom)

One hypothesis for the decline of the North American greater (Aythya marila) and lesser (A. affinis) scaup population is that contaminant burdens acquired on wintering or staging areas impair reproduction or cause lethal or sublethal health effects. Recent studies have found increased selenium (Se) concentrations in scaup but have focused on the fall and spring staging periods. From January to March 2006 and December to March 2006 and 2007, we analyzed liver tissues collected from greater scaup wintering in western Lake Ontario for 16 trace elements. We also measured Se concentrations in greater scaup blood and Dreissenid mussel tissue. Se was the only trace element that occurred at increased concentrations (>10??g/g liver dry weight) in a substantial proportion (99%) of greater scaup live...

2011-01-01

164

Positive effects of UV radiation on a calanoid copepod in a transparent lake: do competition, predation or food availability play a role?  

British Library Electronic Table of Contents (United Kingdom)

Zooplankton tolerant to ultraviolet radiation (UVR) could be indirectly affected by UVR through interactions with UV-sensitive species in the same ecosystem. In Lake Giles, Pennsylvania, USA, the calanoid copepod Leptodiaptomus minutus is more UVR tolerant than the cohabiting species Daphnia catawba and Cyclops scutifer. We asked whether L. minutus is affected by UV-induced mortality of a food competitor (D. catawba) or a predator of its nauplii (C. scutifer). We conducted two in situ enclosure experiments with six treatments: L. minutus alone, L . minutus + Daphnia and L. minutus + Cyclops in the presence and absence of UVR. There were few differences in survival among treatments in Experiment 1, which had enhanced food and a cumulative UVR (320 nm) dose of 9.3 kJ m-2. In Experiment 2, wh...

2006-01-01

165

Measurement of Lake Roosevelt biota in relation to reservoir operations. Appendices 1991  

International Nuclear Information System (INIS)

This report consists of appendices A-F containing the biological data which were collected from Lake Roosevelt, Washington. The data are to be used in the design of a computer model that would predict biological responses of reservoir operations as part of the System Operation Review program. Major components of the model included: Quantification of impacts to phytoplankton, zooplanktons, benthic invertebrates, and fish caused by reservoir drawdowns and low water retention times; quantification of number, distribution, and use of fish food organisms in the reservoir by season; determination of seasonal growth of fish species as related to reservoir operations, prey abundance and utilization; and quantification of entrainment levels of zooplankton and fish as related to reservoir operations and water retention times.

1995-11-05

166

Influence of migrant tundra swans (Cygnus columbianus) and Canada geese (Branta canadensis) on aquatic vegetation at Long Point, Lake Erie, Ontario  

British Library Electronic Table of Contents (United Kingdom)

Numerous studies have shown that large, herbivorous waterfowl can reduce quantity of aquatic plants during the breeding or wintering season, but relatively few document herbivory effects at staging areas. This study was done to determine if feeding activities of tundra swans (Cygnus columbianus columbianus) and Canada geese (Branta canadensis) had a measurable additive influence on the amount of aquatic plants, primarily muskgrass (Chara vulgaris), wild celery (Vallisneria americana), and sago pondweed (Potamogeton pectinatus), removed during the fall migration period at Long Point, Lake Erie, Ontario. Exclosure experiments done in fall 1998 and 1999 showed that, as compared to ducks and abiotic factors, these two large herbivorous waterfowl did not have any additional impact on above or b...

2006-01-01

167

Improvement of lake water quality by paying farmers to abate nonpoint source pollution. Research report  

Energy Technology Data Exchange (ETDEWEB)

To mitigate damages caused by agricultural runoff, private lake owners' associations are paying for inlake and instream pollution abatement measures and on land-conservation practices. This phenomenon supports the notion that individuals who benefit from improved water quality should be willing to pay part of the abatement costs. The research suggests that on land-conservation measures can substantially reduce sediment delivery at low cost. The Sediment Economics (SEDEC) model was modified and then used to select and to site management systems that achieved stated sediment goals at least cost. Other resource policies such as T value, no-till, and contouring were compared with the least-cost frontier and shown to be more costly. The noncropland areas substantially reduced sediment delivery to water channels and lowered abatement costs. Further research is needed for long-range watershed-planning models such as SEDEC.

1988-12-01

168

Geochemical fingerprints by activation analysis of tephra layers in Lake Van sediments, Turkey  

International Nuclear Information System (INIS)

We discuss geochemical and sedimentological characteristics of 12 tephra layers, intercalated within the finely laminated sediments of Lake Van. Within the about 15 kyr long sediment record studied, volcanic activity concentrated in the periods 2.6-7.2 and 11.9-12.9 kyr B.P. Concentrations of 25 elements provide the geochemical fingerprint of each tephra layer and allow comparison to literature values of potential source volcanoes such as Mts. Nemrut and Suephan. The youngest two tephra layers (and probably also the other three ashes from the 2.6-7.2 kyr B.P. eruptions) originate from the Nemrut volcano. The source of the older tephra (11.9-12.9 kyr B.P.), however, remains unidentified.

2011-07-01

169

Description of Cretaceous Sedimentary Sequence of the Quantou Formation Recovered by CCSD-SK-Is Borehole in Songliao Basin: Lithostratigraphy, Sedimentary Facies and Cyclic Stratigraphy  

British Library Electronic Table of Contents (United Kingdom)

The Quantou Formation recovered by CCSD-SK-Is borehole (China Cretaceous Continental Scientific Drilling-SongkeI-the south borehole) is 132.07 m long and the recovery of cores is 100%. The sequence and process of lithology-lithofacies and cyclostratigraphy are revealed by a detailed core description. Nine rock types and three kinds of sedimentary facies including meandering river, shallow lake, and delta front are recognized from the drilling core, there are ten sedimentary microfacies, which are point bar, natural levee, crevasse splay, crevasse channel, floodplain, flood lake, distributary mouth bar, interdistributary bay, mudstone of still water, and turbidite. The Quantou Formation represents seventy-six meter-scale cycles (sixth-order cycle), twenty-five fifth-order cycles, eight four...

2009-01-01

170

Contaminants in Lesser and Greater Scaup Staging on the Lower Great Lakes  

British Library Electronic Table of Contents (United Kingdom)

The decrease and subsequent lack of recovery of the North American scaup population has increased concerns about contaminants acquired during migration. We collected 189 fall- and spring-migrant lesser (Aythya affinis) and greater scaup (A. marila) on the lower Great Lakes (LGL) to determine if organic contaminants and trace elements in scaup livers were increased and to evaluate sources of variation in selenium (Se) burdens. We found that all organic contaminants were below toxic levels. Of 18 trace elements, only Se was detected at increased (>10-ppm dry-mass) levels. Se in lesser scaup increased but remained constant in greater scaup throughout fall; levels were increased in 14% of lesser scaup and 46% of greater scaup. During spring, Se increased in lesser scaup but decreased slightly ...

2007-01-01

171

Assessment of the sensitivity and prediction uncertainty of evaporation models applied to Nasser Lake, Egypt  

British Library Electronic Table of Contents (United Kingdom)

SummaryThis paper examines the sensitivity and uncertainty of evaporation estimates from Nasser Lake, south of Egypt using data collected at the floating station Raft, 2km upstream of the Aswan High Dam, and 12 evaporation models. Based on their approach the evaporation models were ranked in five classes, respectively the Bowen ratio energy budget (BREB) approach, three energy-aerodynamic based methods, a mass transfer method, two temperature and five solar radiation-temperature approaches. State dependent parameter models were used to estimate the sensitivity indices of the different evaporation estimation methods at daily and monthly frequencies. A drastic reduction in the cost of the sensitivity analysis was obtained when coupled with efficient sampling methods, producing quasi-Monte Ca...

2010-01-01

172

A 1500-year record of lead, copper, arsenic, cadmium, zinc level in Antarctic seal hairs and sediments  

British Library Electronic Table of Contents (United Kingdom)

To reconstruct the profiles of heavy metal levels in the South Ocean ecosystem of Antarctica, the concentrations of lead (Pb), copper (Cu), arsenic (As), cadmium (Cd), and zinc (Zn) in seal hairs and lake sediments spanning the past 1500?years from Fildes Peninsula of King George Island and in weathering lake sediments from Nelson Island of West Antarctica were determined. The lead contents in the seal hairs and the weathering sediments show a sharp increase since the late 1800s, very likely due to anthropogenic contamination from modern industries. After the 1980s, the Pb content in seal hairs dropped by one-third, apparently due to the reduced usage of leaded gasoline in the Southern Hemisphere. Copper arises mainly from the weathering process, and its level may be substantially affected...

2006-01-01

173

1,800 Years of abrupt climate change, severe fire, and accelerated erosion, Sierra Nevada, California, USA  

British Library Electronic Table of Contents (United Kingdom)

This paper provides both a detailed history of environmental change in the Sierra Nevada over the past 1,800?years and evidence for climate teleconnections between the Sierra Nevada and Greenland during the late Holocene. A review of Greenland ice core data suggests that the magnitudes of abrupt changes in temperature and precipitation increased beginning c. 3,700 and 3,000?years ago, respectively. Precipitation increased abruptly 1,300?years ago. Comparing paleotemperature data from Cirque Peak, CA with paleoprecipitation data from Pyramid Lake, NV suggests that hot temperatures occurred at the beginnings of most severe droughts in the Sierra Nevada over the past 1,800?years. Severe fires and erosion also occurred at Coburn Lake, CA at the beginning of all severe droughts in the Sierra Ne...

2011-01-01

174

"2"2"2Rn as indicator of atmospheric turbulence: measurements at Lake Maggiore and on the pre-Alps  

International Nuclear Information System (INIS)

Radon concentration measurements in atmosphere were taken in years from 1997 to 1999 in Milan and at pre-alpine sites located north of Lombardy. In this paper the results of measuring campaigns and a comparison of radon levels observed in the hilly area north of the town and on the pre-Alps are reported. The general criteria of the measurements and the interpretative models of radon concentration are presented. The Lake Maggiore area shows evidence of a great nocturnal stability and frequent formation of Nocturnal Stable Layer. The peculiar findings in the high altitude stations confirm the use of radon as an indicator of atmospheric dispersion of pollutants in an area with complex orography. The afternoon minimum values are concordant for the different stations: this implies a remixing in afternoon hours over the whole area investigated.

175

Metabolism of benzo(a)pyrene by isolated perfused testis and testicular homogenate  

Energy Technology Data Exchange (ETDEWEB)

In an effort to improve the extrapolation of laboratory data to man and estimate risk of human reproductive toxicity associated with environmental exposure, the pharmacokinetic parameters of the testicular compartment are being studied. Of particular interest is the variety of enzyme systems capable of activating and detoxicating environmental chemicals and drugs. This report compares the metabolism of benzo(a)pyrene by the isolated perfused testis and testicular homogenates in vitro. The cell free in vitro system metabolized benzo(a)pyrene at a much greater rate than the perfused testis and produced a different spectrum of metabolites. Reliable laboratory prediction of biotransformation by the whole organ or intact animal is an essential aspect of reproductive toxicology.

1980-12-01

176

Inborn Errors of Metabolism Presenting in Childhood  

British Library Electronic Table of Contents (United Kingdom)

Abstract Neurodegenerative and neurometabolic disorders may cause significant morbidity and mortality in children. Imaging is important in early diagnosis of metabolic disorders and in determining the extent of brain injury. Especially after the development of new techniques such as diffusion-weighted magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), neuroimaging plays more important role in the diagnosis and management of these disorders. In these disorders, usually a mutation causes a clinically significant block in one or more metabolic pathways. This blockage usually results in either a deficiency of the product or in an accumulation of substrate with damage induced by either storage or toxicity. The presenting symptoms are usually nonspecific. In some of the ...

2011-01-01

177

Hypothalamic control of energy and glucose metabolism  

British Library Electronic Table of Contents (United Kingdom)

The central nervous system (CNS), generally accepted to regulate energy homeostasis, has been implicated in the metabolic perturbations that either cause or are associated with obesity. Normally, the CNS receives hormonal, metabolic, and neuronal input to assure adequate energy levels and maintain stable energy homeostasis. Recent evidence also supports that the CNS uses these same inputs to regulate glucose homeostasis and this aspect of CNS regulation also becomes impaired in the face of dietary-induced obesity. This review focuses on the literature surrounding hypothalamic regulation of energy and glucose homeostasis and discusses how dysregulation of this system may contribute to obesity and T2DM.

2011-01-01

178

[F-18]FDG PET metabolic indices for the evluation of glioma  

International Nuclear Information System (INIS)

[F-18]FDG PET brain imaging is an accurate predictor of primary brain tumor grading and prognosis. The purpose of this study was to evaluate simplified [F-18]FDG PET metabolic indices as indicators of proliferative activity of brain tumor cells. Twenty-five patients with glioma were studied with [F-18]FDG PET. From the tissue radioactivity ratios, following tumor metabolic indices were calculated: 1) the tumor-to-whole brain ratio (T/WB), 2) the ratio of tumor-to-contralateral gray matter at the level of centrum semiovale (T/GM), 3) the ratio of tumor-to-contralateral white matter at the level of centrum semiovale (T/WM), 4) the tumor-to-ipsilateral cerebella ratio (T/iCB) and 5) the tumor-to-contralateral cerebellar ratio (T/cCB). A standardized threshold method was used to define ROIs in the tumor areas having representative metabolic activites. Correlations of the tumor metabolic indices with ...

1997-05-16

179

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates?  

UK PubMed Central (United Kingdom)

Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes...Full Text Available

2008-06-01

180

Transformation of Verapamil by Cunninghamella blakesleeana  

UK PubMed Central (United Kingdom)

A filamentous fungus, Cunninghamella blakesleeana AS 3.153, was used as a microbial model of mammalian metabolism to transform verapamil, a calcium channel antagonist. The metabolites...Full Text Available

2004-05-01

181

The diagnosis of young-onset dementia  

UK PubMed Central (United Kingdom)

A diagnosis of dementia is devastating at any age but diagnosis in younger patients presents a particular challenge. The differential diagnosis is broad as late presentation of metabolic disease...Full Text Available

2010-08-01

182

The cardiomyopathy associated with methylsalicylate  

UK PubMed Central (United Kingdom)

Dogs challenged with toxic doses of methylsalicylate developed acute myocardiopathy. Metabolic manifestations of uncoupling of oxidative phosphorylation by methylsalicylate (MS) were observed. Oxygen...Full Text Available

1975-05-01

183

Self-similarity in NMR Spectra: An Application in Assessing the Level of Cysteine  

UK PubMed Central (United Kingdom)

High resolution of NMR spectroscopic data of biosamples are a rich source of information on the metabolic response to physiological variation or pathological events. There are many advantages...Full Text Available

2010-01-01

184

Obesity and periodontal disease  

UK PubMed Central (United Kingdom)

Obesity is characterized by the abnormal or excessive deposition of fat in the adipose tissue. Its consequences go far beyond adverse metabolic effects on health, causing an increase in oxidative stress,...Full Text Available

2010-04-01

185

Mitochondrial uncoupling and lifespan  

UK PubMed Central (United Kingdom)

The quest to understand why we age has given rise to numerous lines of investigation that have gradually converged to include metabolic control by mitochondrial activity as a major player. That...Full Text Available

2010-01-01

186

Mitochondria and PGC-1? in Aging and Age-Associated Diseases  

UK PubMed Central (United Kingdom)

Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders. While the cause of aging and its associated diseases...Full Text Available

187

JMassBalance: mass-balanced randomization and analysis of metabolic networks  

British Library Electronic Table of Contents (United Kingdom)

Summary: Analysis of biological networks requires assessing the statistical significance of network-based predictions by using a realistic null model. However, the existing network null model, switch randomization, is unsuitable for metabolic networks, as it does not include physical constraints and generates unrealistic reactions. We present JMassBalance, a tool for mass-balanced randomization and analysis of metabolic networks. The tool allows efficient generation of large sets of randomized networks under the physical constraint of mass balance. In addition, various structural properties of the original and randomized networks can be calculated, facilitating the identification of the salient properties of metabolic networks with a biologically meaningful null model. Availability and Imp...

2011-01-01

188

Issues in the Pharmacokinetics of Trichloroethylene and Its Metabolites  

UK PubMed Central (United Kingdom)

Much progress has been made in understanding the complex pharmacokinetics of trichloroethylene (TCE). Qualitatively, it is clear that TCE is metabolized to multiple metabolites either locally or into...Full Text Available

2006-09-01

189

If I Had - A Family Member with Metabolic Syndrome  

Medline Plus

... elevated blood sugar levels, but not full-blown diabetes. What are the keys to preventing the disease? ... been well studied, in a study called The Diabetes Prevention Program, in several thousand people with this ...

190

Homocysteine and Familial Longevity: The Leiden Longevity Study  

UK PubMed Central (United Kingdom)

Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor...Full Text Available

191

HbA1c: MedlinePlus Medical Encyclopedia  

Science.gov (United States)

MD, Chief, Division of Endocrinology, Diabetes and Metabolism, Trinitas Regional Medical Center, Elizabeth, NJ. Review provided by VeriMed Healthcare Network. Also reviewed...

2011-08-30

192

Francisella Tularensis Metabolism and its Relation to Virulence  

UK PubMed Central (United Kingdom)

Francisella tularensis is a Gram-negative bacterium capable of causing the zoonotic disease tularaemia in a large number of mammalian species and in arthropods. F. tularensis...Full Text Available

193

Focal fits during chlorambucil therapy  

UK PubMed Central (United Kingdom)

An elderly man receiving chlorambucil for chronic lymphatic leukaemia developed focal fits. The onset and frequency were dose related. There was no evidence of metabolic disturbance or of meningeal...Full Text Available

1979-11-01

196

Diabetic complications and dysregulated innate immunity  

UK PubMed Central (United Kingdom)

Diabetes mellitus is a metabolic disorder that leads to the development of a number of complications. The etiology of each diabetic complication is undoubtedly multifactorial. We will focus...Full Text Available

197

Current Projects - Human Nutrition Research Center on Aging ...  

Science.gov (United States)

diet and genetic obesity metabolic defects and inflammation. To determine the role of adipocyte death in promoting adipose tissue inflammation and insulin resistance in animal...

2011-08-31

198

Citrate Fermentation by Lactococcus and Leuconostoc spp  

UK PubMed Central (United Kingdom)

Citrate and lactose fermentation are subject to the same metabolic regulation. In both processes, pyruvate is the key intermediate. Lactococcus lactis subsp. lactis...Full Text Available

1991-12-01

199

Apheresis affects bone and mineral metabolism  

British Library Electronic Table of Contents (United Kingdom)

Background: Apheresis is a procedure to selectively obtain blood components. For the collection process citrate is routinely used. It inhibits coagulation by binding to ionized calcium and leads to metabolic alkalosis. Objective: Whether regular apheresis affects bone and mineral metabolism is unknown. The intention of this study was to investigate 1) the acute effects of apheresis on acid-base balance, bone and mineral metabolism and 2) to compare bone mineral density (BMD) at the lumbar spine and hip of donors to matched control subjects. Design: In this open, observational, single-center, cross-sectional study we enrolled 102 regular plasma and thrombocyte donors to pursue objective 1) and compared those to 102 matched controls (CTR) for objective 2). Results: Platelet donation led to s...

2010-01-01

200

Spectral characteristics of lignite open cast mining systems: a preliminary status  

Energy Technology Data Exchange (ETDEWEB)

The application of a Compact Airborne Spectrographic Imager to assessment and monitoring of lakes in a lignite open cast mining area in central Germany is described. The imager was used in combination with additional ground experiments, such as field spectroscopy and water sampling. The spectral characteristics of an instrument under development for monitoring geochemical and hydrological processes are presented. Summary form only.

1999-07-01

201

Spectral absorption properties of colored dissolved organic matter (CDOM) and total suspended matter (TSM) of inland waters  

Science.gov (United States)

Spectral absorption properties of total suspended matter (TSM) and colored dissolved organic matter (CDOM) are important for the use of the bio-optical model to estimate water quality parameters. This study aims to investigate the variation in the absorption coefficients of TSM and CDOM of inland waters. A total of 92 water samples were collected from Shitoukoumen Reservoir and Songhua Lake in Northeast China, analyzed for TSM and Chl-a, and measured for the absorption coefficient of TSM, CDOM and total pigments using a laboratory spectrophotometer. The absorption coefficient of TSM has been decomposed for phytoplankton and inorganic sediments. The results show that for Shitoukoumen Reservoir, CDOM has strong absorptions with shallow absorption slopes (i.e., the coefficient S in a(?)=a(?0)exp[-S(?- ?0)]) and large absorption at 355 nm; and for Songhua Lake, CDOM follows similar spectral absorption curves but less variation in the S value. The ...

2010-08-01

202

Snake River Sockeye Salmon Habitat and Limnological Research; 1995 Annual Report.  

Energy Technology Data Exchange (ETDEWEB)

This report contains studies which are part of the Bonneville Power Administration`s program to protect, mitigate, and enhance fish and wildlife affected by the development and operation of hydroelectric facilities on the Columbia River and its tributaries. Attention is focused on population monitoring studies in the Sawtooth Valley Lakes. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

1996-05-01

203

Natural gas in Lake Erie: a reconnaissance survey of discharges from an offshore drilling rig  

Energy Technology Data Exchange (ETDEWEB)

Field studies were conducted May 28-June 1, 1979, to determine the chemical composition and physical behavior of discharges from an offshore gas drilling rig in the central basin of Lake Erie. The drilling operation was observed for four days, from rig jackup to the circulation of mud through the borehole after drilling had been completed. Resuspension studies using nephelometry, supplemented with chemical analyses, indicated little resuspension of lake bottom materials or release of metals to the water column during rig jack-up. Portions of the turbidity plumes generated during drilling were buoyant. Three surface turbidity plumes were mapped with nephelometry to a point at which particulate concentrations reached background levels in the Lake. Detectable plumes were approx. 400 to 1500 m in length and had maximum widths < 230 m. A chemical survey conducted in the plume during early gas shows indicated that discharged ...

1980-10-01

204

Integrated Risk Framework for Gigawatt-Scale Deployments of Renewable Energy: The U.S. Wind Energy Case; October 2009  

Energy Technology Data Exchange (ETDEWEB)

Assessing the potential environmental and human effects of deploying renewable energy on private and public lands, along our coasts, on the Outer Continental Shelf (OCS), and in the Great Lakes requires a new way of evaluating potential environmental and human impacts. The author argues that deployment of renewables requires a framework risk paradigm that underpins effective future siting decisions and public policies.

2010-04-01

205

Harmful Algae, Nuisance Blooms and Anthropogenic Nutrient Enrichment  

Environmental Research Database

DescriptionPhytoplankton is the collective name given to the microscopic floating plants in seas and lakes. Under certain conditions, the abundance of phytoplankton as a whole or of one or more species in particular, can reach a magnitude at which it is visible through discolouration of the sea. Some of these blooms because of the colour of the water have been called 'Red Tides'. Blooms of some 300 species of the phytoplankton are known as Harmful Algal Bloom (HAB) species in recognition of their poten [continued...

2009-01-31

206

Density Currents  

Science.gov (United States)

In this activity, students will make a turbidity current. They will discover how fluids of differing densities interact with one another, learn some ways the densities of fluids can be changed and observe how density currents transport and deposit tremendous amounts of sediment in lakes and in the ocean. Additional options allow students to create and observe different kinds of density currents.

207

Airborne lidar experiments at the Savannah River Plant, June 1985  

Energy Technology Data Exchange (ETDEWEB)

Results are presented from a series of studies conducted at the Department of Energy (DOE) Savannah River Plant (SRP) with the NASA Airborne Oceanographic Lidar (AOL). These studies included a topographic survey of a {approximately}1000 acre lake basin (presently designated L Lake) which had been excavated for use as a cooling pond for L Reactor; a study of the movement of discharged cooling water in Pond C and the warm arm of Par Pond using Rhodamine WT dye as a tag; initial baseline studies of the vegetation cover of the Steel Creek corridor (through which the outflow of L Lake is carried to the Savannah River); and a demonstration of potential forestry applications of the AOL. These investigations were conducted over a 3-day period in June 1985. The AOL is an advanced airborne laser system capable of making temporal or time history measurements of laser backscatter (bathymetry mode) or spectral measurements of laser ...

1987-09-01

208

Airborne hyperspectral data for the assessment of open cast lignite mining impacts in central Germany  

Energy Technology Data Exchange (ETDEWEB)

The application of airborne sensors for providing environmental assessment and monitoring of a test site in an open cast mining area that is part of a lignite deposit in central Germany is described. Hyperspectral remote sensing data from three different sensors were tested. The hyperspectral scanner data was suitable for classification of different sediments and vegetation types and the water chemistry of residual mining lakes. Summary form only. 1 tab.

1999-07-01

209

Ribose metabolism and nucleic acid synthesis in normal and glucose-6-phosphate dehydrogenase-deficient human erythrocytes infected with Plasmodium falciparum.  

UK PubMed Central (United Kingdom)

The metabolism of pentose-phosphate was investigated in Plasmodium falciparum-infected normal and glucose-6-phosphate dehydrogenase (G6PD)-deficient human red blood cells in vitro. 5'-Phosphoribosyl-1-pyrophosphate...Full Text Available

1986-04-01

210

Review of tritium metabolism based on urine bioassay results  

Energy Technology Data Exchange (ETDEWEB)

The effective half-life based on urine bioassay results of Wolsung NPP's worker was calculated. The effective half-life for tritiated water vapour obtained was 5 {approx} 9 days. In comparison to 10 days reported for ICRP-30, it is lower than the corresponding half-life for Reference Man. Also, the half-life was calculated based on intake amount of daily water. According to this result, the metabolism was reviewed.

2001-05-01

211

Nuclear receptor co-repressor SMRT regulates mitochondrial oxidative metabolism and mediates aging related metabolic deterioration  

UK PubMed Central (United Kingdom)

SummaryThe transcriptional co-repressor SMRT utilizes two major receptor interacting domains (RID1 and RID2) to mediate nuclear receptor (NR) signaling through epigenetic modification....Full Text Available

2010-12-01

212

Myocardial metabolic regulation through peroxisome proliferator-activated receptor alpha after myocardial infarction  

UK PubMed Central (United Kingdom)

Although peroxisome proliferator-activated receptor alpha (PPARα) is closely associated with myocardial fatty acid metabolism, the pathophysiological role of PPARα in myocardial infarction...Full Text Available

2003-01-01

213

MicroRNAs Regulate Human Hepatocyte Nuclear Factor 4?, Modulating the Expression of Metabolic Enzymes and Cell Cycle*  

UK PubMed Central (United Kingdom)

Hepatocyte nuclear factor (HNF) 4α is a key transcription factor regulating endo/xenobiotic-metabolizing enzymes and transporters. We investigated whether microRNAs are involved in the regulation...Full Text Available

2010-02-12

214

Metabolism of Gibberellin A12 and A12-Aldehyde in Developing Seeds of Pisum sativum L. 1  

UK PubMed Central (United Kingdom)

Metabolism of [14C]gibberellin (GA) A12 (GA12) and [14C]gibberellin A12-aldehyde (GA12-aldehyde) was examined in cotyledons and seed...Full Text Available

1991-09-01

215

Metabolism and Binding of 14C-Maleic Hydrazide 1  

UK PubMed Central (United Kingdom)

Maleic hydrazide (MH) is taken up by corn and pea seedling roots and bound to some material which is insoluble in 80% ethanol or 5% trichloroacetic acid. 14C-MH is stable metabolically; chromatography...Full Text Available

1970-01-01

216

Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice  

UK PubMed Central (United Kingdom)

Little is known about how diet and energy metabolism interact in determination of lifespan under ad libitum feeding. From 12 weeks of age until death, male and female wild-type (WT) and transgenic (TG)...Full Text Available

2011-02-01

217

Clinical and metabolic consequences of two regimens of total parenteral nutrition in the newborn  

UK PubMed Central (United Kingdom)

The clinical and metabolic effects of two regimens of total parenteral nutrition delivering the same amino-acid (2·8 g/kig per 24 h), fat (4·8 g/kg per 24 h), and glucose (12 g/kg per...Full Text Available

1983-03-01

218

A heteromeric complex containing the centromere binding factor 1 and two basic leucine zipper factors, Met4 and Met28, mediates the transcription activation of yeast sulfur metabolism.  

UK PubMed Central (United Kingdom)

Transcription activation of sulfur metabolism in yeast is dependent on two DNA binding factors, the centromere binding factor 1 (Cbf1) and Met4. While the role of Met4 was clearly established by showing...Full Text Available

1996-05-15

219

Reversal of brain metabolic abnormalities following treatment of AIDS dementia complex with 3'-azido-2',3'-dideoxythymidine (AZT, zidovudine): a PET-FDG study  

International Nuclear Information System (INIS)

Brain glucose metabolism was evaluated in four patients with acquired immunodeficiency syndrome (AIDS) dementia complex using ["1"8F]fluorodeoxyglucose (FDG) and positron emission tomography (PET) scans at the beginning of therapy with 3'-azido-2',3'-dideoxythymidine (AZT, zidovudine), and later in the course of therapy. In two patients, baseline, large focal cortical abnormalities of glucose utilization were reversed during the course of therapy. In the other two patients, the initial PET study did not reveal pronounced focal alterations, while the post-treatment scans showed markedly increased cortical glucose metabolism. The improved cortical glucose utilization was accompanied in all patients by immunologic and neurologic improvement. PET-FDG studies can detect cortical metabolic abnormalities associated with AIDS dementia complex, and may be used to monitor the metabolic improvement in response to ...

220

Biogeochemistry of the compost bioreactor components of a composite acid mine drainage passive remediation system  

International Nuclear Information System (INIS)

The compost bioreactor ('anaerobic cell') components of three composite passive remediation systems constructed to treat acid mine drainage (AMD) at the former Wheal Jane tin mine, Cornwall, UK were studied over a period of 16 months. While there was some amelioration of the preprocessed AMD in each of the three compost bioreactors, as evidenced by pH increase and decrease in metal concentrations, only one of the cells showed effective removal of the two dominant heavy metals (iron and zinc) present. With two of the compost bioreactors, concentrations of soluble (ferrous) iron draining the cells were significantly greater than those entering the reactors, indicating that there was net mobilisation (by reductive dissolution) of colloidal and/or solid-phase ferric iron compounds within the cells. Soluble sulfide was also detected in waters draining all three compost bioreactors which was rapidly oxidised, in contrast to ferrous iron. Oxidation and hydrolysis of iron, together with ...

2005-02-01

221

Strain differences in the responsiveness between Sprague-Dawley and Fischer rats to nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor  

British Library Electronic Table of Contents (United Kingdom)

To determine a rat strain appropriate for carcinogenicity testing of FYX-051, a xanthine oxidoreductase inhibitor, we performed a 4-week oral toxicity study by administering 0.3, 1 and 3?mg/kg, and 1, 3 and 10?mg/kg of FYX-051 to male Sprague-Dawley (SD) and Fischer (F344) rats, respectively. Histopathology revealed that the degree of FYX-051-induced nephropathy was 3-fold stronger in SD rats than in F344 rats. Our previous study demonstrated that the key factor of species differences in FYX-051-induced nephropathy is purine metabolism. This observation led us to examine the involvement of purine metabolism in differences among two strains of rats. However, purine metabolism was proven not to be implicated as an important factor. Subsequently, other factors responsible for the strain diffe...

2006-01-01

222

Reductive metabolism of the dinitrobenzamide mustard anticancer prodrug PR-104 in mice  

British Library Electronic Table of Contents (United Kingdom)

Purpose PR-104, a bioreductive prodrug in clinical trial, is a phosphate ester which is rapidly metabolized to the corresponding alcohol PR-104A. This dinitrobenzamide mustard is activated by reduction to hydroxylamine (PR-104H) and amine (PR-104M) metabolites selectively in hypoxic cells, and also independently of hypoxia by aldo-keto reductase (AKR) 1C3 in some tumors. Here, we evaluate reductive metabolism of PR-104A in mice and its significance for host toxicity. Methods The pharmacokinetics of PR-104, PR-104A and its reduced metabolites were investigated in plasma and tissues of mice (with and without SiHa or H460 tumor xenografts) and effects of potential oxidoreductase inhibitors were evaluated. Results Pharmacokinetic studies identified extensive non-tumor reduction of PR-104A to t...

2011-01-01

223

Metabolic engineering of carotenoid accumulation by creating a metabolic sink  

British Library Electronic Table of Contents (United Kingdom)

Carotenoids are highly beneficial for human nutrition and health because they provide essential nutrients and important antioxidants in our diets. However, many food crops, especially the major staple crops contain only trace to low amounts of carotenoids. Although significant progress has been made in developing food crops rich in carotenoids by altering the expression of carotenoid biosynthetic genes, in many cases it has proved to be difficult to reach the desired levels of carotenoid enrichment. The recent identification and characterization of a novel gene mutation in cauliflower reveals that creating a metabolic sink to sequester carotenoids is an important mechanism to control carotenoid accumulation in plants. The successful demonstration of increased carotenoid accumulation in ass...

2007-01-01

224

Metabolic and molecular stress responses of gilthead seam bream Sparus aurata during exposure to low ambient temperature: an analysis of mechanisms underlying the winter syndrome  

British Library Electronic Table of Contents (United Kingdom)

The winter syndrome in the gilthead sea bream Sparus aurata indicates that the species is exposed to critically low temperatures in Mediterranean aquaculture in winter. The present study of metabolic patterns and molecular stress responses during cold exposure was carried out to investigate this ?disease?, in light of the recent concept of oxygen and capacity limited thermal tolerance. The metabolic profile of fuel oxidation was examined by determining the activities of the enzymes hexokinase (HK), aldolase (Ald), pyruvate kinase (PK), l-lactate dehydrogenase (l-LDH), citrate synthase (CS), malate dehydrogenase (MDH) and 3-hydroxyacyl CoA dehydrogenase (HOAD) in heart, red and white muscle after exposure to temperatures of 10, 14 and 18?C. Especially, the increase in LDH activity combined ...

2010-01-01

225

Inhibition of Metabolism of Diethylene Glycol Prevents Target Organ Toxicity in Rats  

British Library Electronic Table of Contents (United Kingdom)

Diethylene glycol (DEG) is an industrial chemical, the misuse of which has led to numerous epidemic poisonings worldwide. The mechanism of its toxicity has not been defined as to the precise relationship between the metabolism of DEG and target organ toxicity. The purpose of this study was to investigate the mechanism for the acute toxicity of DEG, and the effect of the alcohol dehydrogenase inhibitor 4-methylpyrazole (fomepizole), by determining the relationship between accumulation of DEG or its metabolites and the resulting kidney and liver toxicity. Rats were treated by oral gavage with water, 2 g/kg DEG (low dose), 10 g/kg DEG (high dose), or 10 g/kg DEG + fomepizole, and blood and urine were collected over 48 h. Rats treated with high-dose DEG had metabolic acidosis, increased BUN an...

2010-01-01

226

Honokiol enhances adipocyte differentiation by potentiating insulin signaling in 3T3-L1 preadipocytes  

British Library Electronic Table of Contents (United Kingdom)

Adipose tissue plays an essential role in energy homeostasis as a metabolic and endocrine organ. Accordingly, adipocytes are emerging as a major drug target for obesity and obesity-mediated metabolic syndrome. Dysfunction of enlarged adipocytes in obesity is involved in obesity-mediated metabolic syndrome. Adipocytokines, such as adiponectin released from small adipocytes, are able to prevent these disorders. In this study, we found that honokiol, an ingredient of Magnolia officinalis used in traditional Chinese and Japanese medicines, enhanced adipocyte differentiation in 3T3-L1 preadipocytes. Oil Red O staining showed that treatment with honokiol in the presence of insulin dose-dependently increased lipid accumulation in 3T3-L1 preadipoyctes although its activity was weak compared with r...

2011-01-01

227

Effects of swimming training at the intensity equivalent to aerobic/anaerobic metabolic transition in alloxan diabetic rats  

British Library Electronic Table of Contents (United Kingdom)

The present study was designed to determine the exercise intensity equivalent to the metabolic aerobic/anaerobic transition of alloxan diabetic rats, through lactate minimum test (LMT), and to evaluate the effects of swimming exercise at this intensity (LM) on the glucose and protein metabolism of these animals. Adult male Wistar rats received alloxan (SD, alloxan-injected rats that remained sedentary) intravenously (30 mg kg?1 body weight) for diabetes induction. As controls (SC, vehicle-injected rats that remained sedentary), vehicle-injected rats were utilized. Two weeks later, the animals were submitted to oral glucose tolerance test (oGTT) and LMT. After the tests, some of the animals were submitted to swimming exercise training [TC (vehicle-injected rats that performed a 6-week exerc...

2007-01-01

228

Effect of season on contractile and metabolic properties of desert camel muscle (Camelus dromedarius)  

British Library Electronic Table of Contents (United Kingdom)

Thirty fattened one humped desert camels were used to examine the effect of season on contractile and metabolic properties of Longissimus thoracis (LT) muscle. Ten camels were slaughtered according to seasons of the year (winter, summer and autumn). Season significantly influenced muscle chemical composition, ultimate pH (pHu) and color. Activities of metabolic enzymes were higher during autumn season compared to summer and winter for phosphofructokinase (+64% compared to both seasons) and for isocitrate dehydrogenase (+35% and +145% in autumn vs. summer and winter, respectively). Quantification of muscle myosin heavy chain isoforms by SDS-PAGE electrophoresis showed only presence of type I and type IIa MyHC in camel muscle and indicated high proportion in winter for type I and in autumn f...

2012-01-01

229

Distinctive Responses of Metabolically Active Microbiota to Acidification in a Thermophilic Anaerobic Digester  

British Library Electronic Table of Contents (United Kingdom)

Acidification is one of the most common and serious problems inducing process failure in anaerobic digesters. The production of volatile fatty acids (VFAs) mainly triggers acidic shock. However, little is known about the bacteria involved in the processes of acidogenic metabolism, such as fermentation and reductive acetogenesis. Here, the metabolic responses of a methanogenic community to the acidification and resulting process deterioration were investigated using transcriptional profiling of both the 16S rRNA and formyltetrahydrofolate synthetase (FTHFS) genes. The 16S rRNA-based analyses demonstrated that the dynamic shift of bacterial populations was closely correlated with reactor performance, especially with VFA accumulation levels. The pH drop accompanied by an increase in VFAs stim...

2011-01-01

230

Development of an internet based system for modeling biotin metabolism using Bayesian networks  

British Library Electronic Table of Contents (United Kingdom)

Biotin is an essential water-soluble vitamin crucial for maintaining normal body functions. The importance of biotin for human health has been under-appreciated but there is plenty of opportunity for future research with great importance for human health. Currently, carrying out predictions of biotin metabolism involves tedious manual manipulations. In this paper, we report the development of BiotinNet, an internet based program that uses Bayesian networks to integrate published data on various aspects of biotin metabolism. Users can provide a combination of values on the levels of biotin related metabolites to obtain the predictions on other metabolites that are not specified. As an inherent feature of Bayesian networks, the uncertainty of the prediction is also quantified and reported to...

2011-01-01

231

Cyclosporine metabolic side effects: association with the WNK4 system  

British Library Electronic Table of Contents (United Kingdom)

Abstract Background- Cyclosporine is used for treatment of transplanted patients and for immune-mediated diseases. Cyclosporine is known to cause a combination of metabolic side effects including hypertension, hyperkalemia, hypercalciuria and hypomagnesemia. These side effects except for hypomagnesemia are the cardinal features of familial hyperkalemia and hypertension (FHHt), also called pseudohypoaldosteronism type II (PHA II). FHHt is caused by mutations in the kinases WNK1 and WNK4 resulting in an increase in renal Na-Cl cotransporter (NCC) apical distribution and function. Therefore, we studied whether cyclosporine-s metabolic side effects are mediated by WNK4 and NCC. Design- Sprague-Dawley (SD) rats were treated by cyclosporine 25-mg-kg-1 subcutaneously for 14-days. Blood pressure, ...

2011-01-01

232

Comparison of Plasma Antioxidant Levels and Related Metabolic Parameters Between Smokers and Non-smokers  

British Library Electronic Table of Contents (United Kingdom)

The relationship between cigarette smoking and cell damage is complicated, particularly considering the role of oxidative stress. The aim of this study was to identify the relationships among plasma nicotine metabolites, lipophilic antioxidants, and metabolic parameters in smokers and non-smokers. This cross-sectional study recruited 100 subjects who visited the Department of Family Medicine at Kaohsiung Medical University Hospital. Excluding 14 ineligible cases, 46 smokers and 40 non-smokers were enrolled. Plasma nicotine metabolites, lipophilic antioxidants (including retinol, lycopene, a-carotene, b-carotene, d-tocopherol, g-tocopherol and a-tocopherol), related metabolic parameters, and body composition (including height, weight, body mass index, body fat, and waist circumference) were...

2009-01-01

233

Biochemical basis of circadian rhythms and diseases: With emphasis on post-traumatic stress disorder  

British Library Electronic Table of Contents (United Kingdom)

Circadian rhythms affect several processes in the body physiology. This commentary revisits the topic of `metabolic basis of diseases' with a view to shed light on how cellular energy requirements feed-forward to a sequential signaling of hormonal response, blood glucose metabolism, antioxidant activities, and pathophysiology. Attempt is made to explain how diseases that may not appear to be closely related, such as bone metabolism and vasculopathy, have an increase in oxidative damage as a common underlying biochemistry. Importantly, this article identifies oxidative damage as an outcome of sleep disturbance and hypothesize that sleep complaint is not merely one of many resulting symptoms of PTSD, but a core feature that arise from trauma and gives rise to the stress biochemistry, which i...

2011-01-01

234

Application of radiolead to metabolic studies  

International Nuclear Information System (INIS)

A review is presented of the literature through 1977 on the uses of radioactive lead isotopes in metabolic studies in man, animals, and plants. These studies have been done mainly with the naturally-occurring, long-lived (22-yr half life) "2"1"0Pb, but a few were with 53-hr "2"0"3Pb or 10.6-hr "2"1"2Pb. Such studies have made possible estimates of the metabolic parameters of lead in man and animals, such as intestinal absorption, the ratio of fecal-to-urinary excretion of endogenous lead, residence time of lead in the body and in various organs, and the distribution in the body (skeleton, liver, kidney, and blood). Subsequently, these parameters and data have been used to trace the sources of lead for man, such as those from the atmosphere, food, cigarette smoke, and automobile exhaust.

235

Water resources data for Texas, water year 1993. Volume 3. Colorado River basin, Lavaca River basin, Guadalupe River basin, Nueces River basin, Rio Grande basin, and intervening coastal basins. Water-data report (Annual), 1 October 1992-30 September 1993  

Energy Technology Data Exchange (ETDEWEB)

Water-resources data for the 1993 water year for Texas are presented in four volumes, and consist of records of stage, discharge, and water quality of streams and canals; and stage, contents, and water quality of lakes and reservoirs; and water levels and water quality of ground-water wells. Volume 3 contains records for water discharge at 134 gaging stations; stage only at 1 gaging stations; stage and contents at 13 lakes and reservoirs; water quality at 81 gaging stations; and data for 30 partial-record and 4 flood-hydrograph partial-record stations. Also included are lists of discontinued surface-water discharge or stage-only stations and discontinued surface-water-quality stations; crest-stage and flood-hydrograph partial-record stations, reconnaissance partial-record stations, and low-flow partial-record stations.

1994-03-01

236

Tritium in surface waters, tap water and in precipitation in Poland during the 1994-1999 period  

International Nuclear Information System (INIS)

Concentrations of tritium in environmental waters (precipitation, rivers, lakes, tap water) have been determined using electrolytic enrichment and liquid scintillation counting. In waters of big rivers (the Vistula and the Odra rivers), lakes and tap water the annual average concentrations were similar to each other being from 1.4 to 1.9 Bq x dm"-"3. These concentrations were similar to those in the precipitation in which they ranged from 1.7 to 2.2 Bq x dm"-"3. The lowest tritium concentrations were found in waters of the Seashore Region rivers (average for 1994-1999 was 1.1 Bq x dm"-"3). The tritium concentrations in surface waters and in precipitation are still higher than that of natural level. The data obtained show that tritium concentration in the water of rivers might depend on the size of drainage area. The observed seasonal variations of tritium concentration in the precipitation collected in Warsaw and at the Mount Sniezka indicate ...

2001-01-01

237

The uranium deposits of Ontario  

International Nuclear Information System (INIS)

The principal types of uranium deposits in Ontario are carbonatites and fenites, alkalic volcanic rocks, pegiatites, calc-silicate rocks, pyritic quartz-pebble conglomerates, polymictic conglomerates and some pelitic rocks, and various 'pitchblende' deposits including late Precambrian unconformities, possibly late Precambrian diabase dikes, and other unconformities: carbonates, sandstones, lignites, and semi-pelitic rocks of middle and upper Precambrian age. Only red unzoned pegmatite and the pyritic quartz-pebble conglomerate have supported production. Ontario reasonably assured and estimated resources in the economic and subeconomic categories in 1977 amounted to 553 000 tonnes U, and 1977 production was 4000 tonnes U. Measured, indicated, and inferred resources in the Elliot Lake - Agnew Lake area are at least 400 000 tonnes U. The latter deposits are also a significant thorium resource. Geological features reflecting major changes in ...

1990-03-15

238

The restauration of Sullivan mining site : a concept which considers the fauna; La restauration du site minier Sullivan : un concept a caracteres fauniques  

Energy Technology Data Exchange (ETDEWEB)

Mining operations took place at the Sullivan Mine, located at Sullivan, Abitibi, Quebec between 1930 and 1967 and generated large quantities of tailings. These tailings now represent a waste rock pile in the shape of a delta on the shore of De Montigny Lake. The area covers approximately 50 hectares. When the waste rock pile was first established, several terrestrial and aquatic ecosystems were lost forever. In addition, the very nature of the tailings, combined to the action of the wind and lake, further slow the natural site regeneration. The Ministere des Ressources naturelles du Quebec (Quebec Natural Resources Department) asked Les Consultants en Environnement Argus to prepare a site remediation plan to stimulate the natural regeneration of the ecosystems. It would enable the local fauna to resume its occupation of the territory, while ensuring its proper integration in the environment. The authors described in detail the proposed plan ...

2000-07-01

239

The highs and lows of water level : the vulnerability of coastal communities to water level change : final report on the C-CIARN Coastal Zone workshop  

Energy Technology Data Exchange (ETDEWEB)

The Coastal Zone Sector of the Canadian Climate Impact and Adaptation Research Network (C-CIARN) was established to address concerns regarding climate change in coastal areas. Coastal zones are sensitive to increases in air, sea and ground temperatures as well as to variations in sea level, precipitation, ice thickness, and storm intensity. This report presents the results of a workshop which focused on how coastal communities will be affected by climate induced water level changes, particularly sea-level rise on ocean coasts and decreasing lake levels in the Great Lakes. The workshop addressed issues such as the effects of changing water levels on coastal infrastructure, utilities, community development, and the implications of changing water levels to human safety, cultural resources, tourism, and insurance. The workshop reviewed the current state of understanding on water level fluctuations resulting from climate change. It also identified ...

2004-07-01

240

Red mud product development  

Energy Technology Data Exchange (ETDEWEB)

Kaiser Alumina and Chemical Co. impounds red mud, the byproduct of alumina production, behind levees. Kaiser recognizes that this action cannot be maintained indefinitely. Therefore, a project is in progress to produce useful products from red mud that increase the profitability of the Gramercy facility. Before products could be developed, an obstacle had to be overcome. The annual rainfall in South Louisiana prevents evaporative drying of the mud lakes. Innovative methods were applied to dry the lake mud. Two products have been developed. A daily landfill cover and an absorbant, which are marketed under the Cajunite{trademark} banner. Both products are currently being tested by potential customers at their sites. Environmental concerns were addressed during development. Extensive TCLP results show no metal leachate problems. All pilot tests and plant trials received LADEQ approval. Products that are under development include levee core, road ...

1996-10-01

241

Radiological and Environmental Research Division: ecology. Annual report, January-December 1982  

Energy Technology Data Exchange (ETDEWEB)

This is the annual report of the Radiological and Environmental Division of the Argonne National Laboratory for 1982. Studies of the effects of ozone on crop growth and yield have been carried out by the Terrestrial Ecology Group for winter wheat and for sorghum. The Microcosms for Acid Rain Studies (MARS) facility was completed in the early summer. Controlled investigations of plant and soil responses in acid rain were initiated with crop plants grown in two different midwestern soil types. The Transuranics Group has found that the solubility and adsorptive behavior of plutonium previously observed at fallout concentrations in natural waters (approx. 10/sup -16/ to 10/sup -18/ M) is applicable at plutonium concentrations as high as 10/sup -8/ M. The Lake Michigan eutrophication model has been adapted to operation in a Monte Carlo mode. Simulations based on yearly phosphorus loadings and winter conditions were selected at random from prescribed probability ...

1983-09-01

242

CANMET's environmental and process research on uranium  

International Nuclear Information System (INIS)

Environmental research related to uranium tailings is being carried out within the Mining Research Laboratories and Mineral Sciences Laboratories of CANMET, EMR. Field-related research on uranium tailings has been conducted at Elliot Lake for over five years. Much of the work has been focused on a program to rehabilitate pyritic tailings. This has resulted in developing a practicable technology for growing vegetation on such wastes. Limitations have been small size of the test-plots and the relatively short period during which experiments have been carried out. A research program aimed at identifying and reducing acidic and radioactive effluents is also underway at Elliot Lake. These liquid effluents have been identified as the most serious threat to the environment. Research at the Mineral Sciences Laboratories and its predecessor divisions relating to the processing of uranium and thorium ores is outlined. A process has been developed for ...

243

Biological responses to the chemical recovery of acidified fresh waters in the UK  

International Nuclear Information System (INIS)

We report biological changes at several UK Acid Waters Monitoring Network lakes and streams that are spatially consistent with the recovery of water chemistry induced by reductions in acid deposition. These include trends toward more acid-sensitive epilithic diatom and macroinvertebrate assemblages, an increasing proportional abundance of macroinvertebrate predators, an increasing occurrence of acid-sensitive aquatic macrophyte species, and the recent appearance of juvenile (<1 year old) brown trout in some of the more acidic flowing waters. Changes are often shown to be directly linked to annual variations in acidity. Although indicative of biological improvement in response to improving water chemistry, 'recovery' in most cases is modest and very gradual. While specific ecological recovery endpoints are uncertain, it is likely that physical and biotic interactions are influencing the rate of recovery of certain groups of organisms at particular sites. - ...

2005-09-01

244

A 1500-year record of lead, copper, arsenic, cadmium, zinc level in Antarctic seal hairs and sediments  

Energy Technology Data Exchange (ETDEWEB)

To reconstruct the profiles of heavy metal levels in the South Ocean ecosystem of Antarctica, the concentrations of lead (Pb), copper (Cu), arsenic (As), cadmium (Cd), and zinc (Zn) in seal hairs and lake sediments spanning the past 1500 years from Fildes Peninsula of King George Island and in weathering lake sediments from Nelson Island of West Antarctica were determined. The lead contents in the seal hairs and the weathering sediments show a sharp increase since the late 1800s, very likely due to anthropogenic contamination from modern industries. After the 1980s, the Pb content in seal hairs dropped by one-third, apparently due to the reduced usage of leaded gasoline in the Southern Hemisphere. Copper arises mainly from the weathering process, and its level may be substantially affected by climatic conditions. The concentrations of Cd, As, and Zn do not show any clear temporal trends.

2006-12-01

245

Shoreline environment atmospheric dispersion experiment (SEADEX)  

Energy Technology Data Exchange (ETDEWEB)

The purpose of SEADEX was to acquire a comprehensive, high-quality data base for evaluating models of dispersion within coastal zones, it secondary objective was to provide data to help determine which meteorological measurements are most appropriate for emergency preparedness at nuclear power plant sites. The study was conducted in the vicinity of Kewannee, Wisconsin, on the western shore of Lake Michigan. This report describes the design of the study and the data base resulting from it. Both a gas tracer (SF/sub 6/) and a particulate tracer (oil fog) were used. (ACR)

1983-09-01

246

On the optimal taxation of common-pool resources  

British Library Electronic Table of Contents (United Kingdom)

Recent research developments in common-pool resource models emphasize the importance of links with ecological systems and the presence of non-linearities, thresholds and multiple steady states. In a recent paper Kossioris et al. (2008) develop a methodology for deriving feedback Nash equilibria for non-linear differential games and apply this methodology to a common-pool resource model of a lake where pollution corresponds to benefits and at the same time affects the ecosystem services. This paper studies the structure of optimal state-dependent taxes that steer the combined economic-ecological system towards the trajectory of optimal management, and provides an algorithm for calculating such taxes.

2011-01-01

247

Effect of synthetic detergents on germination of fern spores  

Energy Technology Data Exchange (ETDEWEB)

Synthetic detergents constitute one of the most important water pollutants by contaminating the lakes and rivers through domestic and industrial use. Considerable information is now available for the adverse effects of detergents an aquatic fauna including fish, algae, and higher aquatic plants. Marked inhibition of germination in orchids and brinjals and of seedlings growth in raddish suggest that rapidly growing systems could be sensitive to detergent polluted water. The present study of the effect of linear alkyl benzene sulphonate on germination of the spores of a fern, Diplazium esculentum aims at the understanding of the effects of water pollution on pteridophytes and the development of spore germination assay for phytoxicity evaluation.

1986-12-01

248

Capital cost associated with the Trunkline Liquefied Natural Gas Lake Charles Facility  

Energy Technology Data Exchange (ETDEWEB)

The actual cost of constructing the LNG facility was about $589 million, an increase of approximately 258% over the $164 million cost estimate approved by the Federal Power Commission (FPC) in 1977. According to reports submitted by Trunkline LNG, the reasons for the increases included extensive modifications to plant design to ensure safe and reliable construction and greater operating efficiency and compliance with state and federal regulations. Also, extension beyond the original estimated completion date, various labor problems, and general inflation resulted in increased labor and interest costs.

1983-08-31

249

Cadmium and endrin toxicity to fish in waters containing mineral fibers  

Energy Technology Data Exchange (ETDEWEB)

Taconite tailings and their component asbestiform minerals in Lake Superior water had no demonstrable effect on the chronic toxicity of cadmium to the flagfish, Jordanella floridae. Maximum acceptable toxicant concentrations determined in life cycle tests, where effects on survival, growth, reproduction, and bioconcentration were used as endpoints, were between 3.3 to 7.4, 3.0 to 6.5, and 3.4 to 7.3 micrograms cadmium/liter at 0.004, 0.08, and 0.95 mg/liter taconite tailings concentrations, respectively.

1982-05-01

250

ALKALINE LEACH-FILTRATION PILOT PLANT TESTING OF HOMESTAKE ORE-SECTION 32  

Science.gov (United States)

Homestake Ore from the Ambrosia Lake District of New Mexico was treated in the Alkaline Leach-- Filtration Pilot Plant at Grand Junction, Colorado. Detailed information on grinding, leaching, flltration, and precipitation in connection with the processing of this ore is given. Autoclave leaching and continuous yellow cake precipitation were employed. The circuit liquors contnined organic material that was detrimental to clariflcation and precipitation and the results show that ihe ore was amenable to the Alkaline Leach--Filtration process only if a special additive was used. (auth)

1958-06-19

251

A truly commercial product  

International Nuclear Information System (INIS)

In one of the first uses of high Tc superconductors in an end-use product, Lake Shore Cryotronics and a Swiss lab have developed a liquid nitrogen level sensor using a high Tc thin film. The probe is manufactured using a seamless stainless steel tube with an yttrium-based zirconium oxide flame-sprayed on the tube. A plasma-sprayed superconductor compound is deposited on top of that. The probe is coated with a sealant that protects the superconducting film from the atmosphere. This manufacturing method has yielded an extremely durable product. Unaffected by ice formation and related mechanical problems, the superconducting level sensor can be kept in the dewar for long periods of time.

252

Use of nuclear techniques in studies of uptake and metabolic fate of xenobiotics in plants  

International Nuclear Information System (INIS)

The use of municipal sewage sludge as a fertilizer in agriculture is a convenient method of disposal. However, sludge is often contaminated with toxic organic compounds such as dioxins, polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs), with implications for soil fertility and quality of crops for human and animal consumption. These compounds can be assimilated by intact plants or in-vitro cell-Culture systems. The amount of uptake depends on the plant species and on the physico-chemical conditions that influence, for example, molecular configuration; uptake rates are higher with low-molecular-weight and polar compounds. The xenobiotic can be converted to polar conjugates and hydroxylated metabolites that may also be toxic. In some cases, large amounts of the compound and/or its metabolic products are incorporated into non-extractable residues. The bound residues, especially those associated with carbohydrate fractions of the cell wall, ...

1997-10-01

253

Universal model for water costs of gas exchange by animals and plants  

UK PubMed Central (United Kingdom)

For terrestrial animals and plants, a fundamental cost of living is water vapor lost to the atmosphere during exchange of metabolic gases. Here, by bringing together previously developed models for...Full Text Available

2010-05-04

254

Twist-1 is a PPAR ?-inducible, negative feedback regulator of PGC-1 ? in brown fat metabolism  

UK PubMed Central (United Kingdom)

SummaryBrown fat is specialized in energy expenditure, a process that is principally controlled by the transcriptional co-activator PGC-1α. Here we describe a molecular...Full Text Available

2009-04-03

255

Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes  

UK PubMed Central (United Kingdom)

BackgroundTransposons, i.e. transposable elements (TEs), are the major internal spontaneous mutation agents for the variability of eukaryotic genomes. To address the general issue...Full Text Available

256

Transcriptional coactivator PGC-1? promotes peroxisomal remodeling and biogenesis  

UK PubMed Central (United Kingdom)

Mitochondria and peroxisomes execute some analogous, nonredundant functions including fatty acid oxidation and detoxification of reactive oxygen species, and, in response to select metabolic cues, undergo...Full Text Available

2010-11-23

257

Toxic Effects of Linear Alkylbenzene Sulfonate on Metabolic Activity, Growth Rate, and Microcolony Formation of Nitrosomonas and Nitrosospira Strains  

UK PubMed Central (United Kingdom)

Strong inhibitory effects of the anionic surfactant linear alkylbenzene sulfonate (LAS) on four strains of autotrophic ammonia-oxidizing bacteria (AOB) are reported. Two Nitrosospira...Full Text Available

2001-06-01

258

Total pancreatectomy for cancer. An appraisal of 65 cases.  

UK PubMed Central (United Kingdom)

Sixty-five patients operated with total pancreatectomy were reviewed with respect to factors influencing operative mortality and morbidity, long-term survival, and metabolic sequelae. The diagnoses...Full Text Available

1977-12-01

259

The structural design of the bat wing web and its possible role in gas exchange  

UK PubMed Central (United Kingdom)

The structure of the skin in the epauletted fruit bat (Epomophorus wahlbergi) wing and body trunk was studied with a view to understanding possible adaptations for gas metabolism and...Full Text Available

2007-12-01

260

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation  

UK PubMed Central (United Kingdom)

Purpose of ReviewThe vertebrate cap’n’collar family transcription factor Nrf2 and its invertebrate homologs SKN-1 (in worms) and CncC (in flies) function...Full Text Available

2011-01-01

261

The preparation of a `metal-free' nappy and its application to metabolic balances in children  

UK PubMed Central (United Kingdom)

Disposable nappies (diapers) have been satisfactorily demineralized and used for the collection of excreta from infants and young children during mineral and trace metal balances. It was possible to...Full Text Available

1972-11-01

262

The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms  

UK PubMed Central (United Kingdom)

Reactive oxygen species (ROS), inevitable byproducts of aerobic metabolism, are known to cause oxidative damage to cells and molecules. This, in turn, is widely accepted as a pivotal determinant of...Full Text Available

2008-09-01

263

The metabolism of hexachlorocyclohexanes and pentachlorocyclohexenes in flies and grass grubs  

UK PubMed Central (United Kingdom)

1. γ-Hexachlorocyclohexane, γ-pentachlorocyclohexene and δ-pentachlorocyclohexene were converted by houseflies and grass grubs into metabolites that had chromatographic properties...Full Text Available

1969-06-01

264

The human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces  

UK PubMed Central (United Kingdom)

Peripheral subunit binding domains (PSBDs) are integral parts of large multienzyme complexes involved in carbohydrate metabolism. PSBDs facilitate shuttling of prosthetic groups between different catalytic...Full Text Available

2010-09-01

265

The effects of thiamin on lead metabolism: organ distribution of lead 203.  

UK PubMed Central (United Kingdom)

The effect of thiamin on the organ distribution of lead was evaluated in CD-1 mice exposed intragastrically or intraperitoneally to a single dose of lead acetate (100 micrograms) containing 100 microCi...Full Text Available

1992-07-01

266

The conversion of DDT to DDE by some anophelines  

UK PubMed Central (United Kingdom)

The metabolism of DDT has been followed in pure lines of laboratory-reared resistant and susceptible anophelines using gas-liquid chromatography. Relatively large amounts of DDE were formed in...Full Text Available

1964-01-01

267

The between and within day variation in gross efficiency  

UK PubMed Central (United Kingdom)

Before the influence of divergent factors on gross efficiency (GE) [the ratio of mechanical power output (PO) to metabolic power input (PI)] can be assessed, the variation in GE between days, i.e. the...Full Text Available

2010-08-01

268

The URE2 protein regulates nitrogen catabolic gene expression through the GATAA-containing UASNTR element in Saccharomyces cerevisiae.  

UK PubMed Central (United Kingdom)

Many of the gene products that participate in nitrogen metabolism are sensitive to nitrogen catabolite repression (NCR), i.e., their expression is decreased to low levels when readily used nitrogen...Full Text Available

1994-12-01

269

The Role of Thyroid Hormone in Testicular Development and Function  

UK PubMed Central (United Kingdom)

Thyroid hormone is a critical regulator of growth, development and metabolism in virtually all tissues, and altered thyroid status affects many organs and systems. Although for many years testis...Full Text Available

2008-12-01

270

The Pregnane X Receptor: From Bench to Bedside  

UK PubMed Central (United Kingdom)

BackgroundThe pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of metabolic enzymes and transporters involved...Full Text Available

2008-07-01

271

The Metabolism of Oat Leaves during Senescence  

UK PubMed Central (United Kingdom)

When the detached first leaves of green or etiolated oat (Avena sativa cv. Victory) seedlings senesce in the dark, their oxygen consumption shows a large increase, beginning after 24...Full Text Available

1974-09-01

272

The Association of Alcohol and Alcohol Metabolizing Gene Variants with Diabetes and Coronary Heart Disease Risk Factors in a White Population  

UK PubMed Central (United Kingdom)

BackgroundEpidemiological studies have shown a J- or U-shaped relation between alcohol and type 2 diabetes and coronary heart disease (CHD). The underlying mechanisms are not clear....Full Text Available

274

Stressed-Induced TMEM135 Protein Is Part of a Conserved Genetic Network Involved in Fat Storage and Longevity Regulation in Caenorhabditis elegans  

UK PubMed Central (United Kingdom)

Disorders of mitochondrial fat metabolism lead to sudden death in infants and children. Although survival is possible, the underlying molecular mechanisms which enable this outcome have not yet been...Full Text Available

275

Spacelab Science Results Study - NASA Technical Report Server (NTRS)  

Science.gov (United States)

Microbial/epithelial tissue. Szylit, O. Metabolic potential/microflora. Szylit, O. Lipid peroxidation. Popova, I.A. SLS-2. STS-58. 1993 ...

276

Some New Aspects of the in Vivo Assay for Nitrate Reductase in Wheat (Triticum aestivum L.) Leaves  

UK PubMed Central (United Kingdom)

Experiments were carried out to clarify problems encountered in measuring metabolic and storage pool sizes of nitrate in wheat leaf sections with an in vivo nitrate reductase assay....Full Text Available

1980-01-01

277

Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent  

UK PubMed Central (United Kingdom)

SummarySoluble epoxide hydrolase (sEH) is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs). Genetic variations...Full Text Available

2009-03-01

278

Short-term effects of tumor necrosis factor on energy and substrate metabolism in dogs.  

UK PubMed Central (United Kingdom)

In vivo short-term effects of recombinant human TNF-alpha on lipolysis, FFA flux, fat oxidation, triglyceride-fatty acid cycling, and glucose kinetics were evaluated with stable isotopic tracers and...Full Text Available

1993-06-01

279

Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors  

UK PubMed Central (United Kingdom)

BackgroundCurrently used indicators of iron status have limitations. Hepcidin, a key regulator of iron metabolism, is reduced in iron deficiency. We sought to determine the properties...Full Text Available

2011-08-01

280

Selective metabolic stimulation of the subfornical organ and pituitary neural lobe by peripheral angiotensin II  

Energy Technology Data Exchange (ETDEWEB)

The subfornical organ is a major receptor area for one of the principal stimuli of thirst, the octapeptide, angiotensin II. In conscious water-sated rats, the authors examined the effects of intravenous infusion of angiotensin II on the rate of glucose utilization in the subfornical organ and in structures anatomically and functionally connected with it. Angiotensin II produced pressor and drinking responses and increased glucose utilization selectively in the subfornical organ and pituitary neural lobe and in no other brain structure. Treatment with the angiotensin II antagonist, sar1-leu8-angiotensin II, before intravenous administration of angiotensin II prevented metabolic stimulation of the subfornical organ and neural lobe. Captopril, an inhibitor of angiotensin-converting enzyme, reduced subfornical organ glucose metabolism to a level similar to that found in control animals. These results demonstrate that peripheral angiotensin II ...

1985-01-01

281

Seasonal proteomic changes reveal molecular adaptations to preserve and replenish liver proteins during ground squirrel hibernation  

UK PubMed Central (United Kingdom)

Hibernators are unique among mammals in their ability to survive extended periods of time with core body temperatures near freezing and with dramatically reduced heart, respiratory, and metabolic rates...Full Text Available

2010-02-01

282

Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin.  

UK PubMed Central (United Kingdom)

To investigate the role of thyroxine-binding globulin (TBG) and albumin in the availability of thyroid hormones to peripheral tissues, comprehensive kinetic studies of thyroxine (T4) and triiodothyronine...Full Text Available

1987-08-01

283

Retardation of Bean Leaf Senescence by Benzyladenine and Its Influence on Phosphate Metabolism 1  

UK PubMed Central (United Kingdom)

The levels of glucose, sugar phosphates, and adenosine phosphates were determined in primary leaves of intact bean plants during normal senescence and compared to leaves in which senescence was delayed...Full Text Available

1970-10-01

284

Regulation of lactose catabolism in Streptococcus mutans: purification and regulatory properties of phospho-beta-galactosidase.  

UK PubMed Central (United Kingdom)

Phospho-beta-galactosidase (P-beta-gal), the enzyme which catalyzes the first step in the metabolism of intracellular lactose phosphate, occurred at high specific activity in the cytoplasm in 12 of...Full Text Available

1979-01-01

285

Regulation of Energy Metabolism Pathways by Estrogens and Estrogenic Chemicals and Potential Implications in Obesity Associated with Increased Exposure to Endocrine Disruptors  

UK PubMed Central (United Kingdom)

The prevalence of obesity among children, adolescents and adults has been dramatically increasing worldwide during the last several decades. The obesity epidemic has been recognized as one of...Full Text Available

2009-07-01

286

Rapid oscillations in omental lipolysis are independent of changing insulin levels in vivo  

UK PubMed Central (United Kingdom)

Abnormal fat metabolism plays an important role in the pathogenesis of obesity-related type 2 diabetes mellitus. This study examined whether free fatty acid levels (FFAs), like insulin levels, oscillate...Full Text Available

2000-08-01

287

Rapid Phytochrome-mediated Changes in Adenosine 5?-Triphosphate Content of Etiolated Bean Buds 1  

UK PubMed Central (United Kingdom)

This study was designed to determine the effects of red and far red irradiation on ATP metabolism in etiolated bean buds (Phaseolus vulgaris L. var. Red Kidney). Compared to dark controls,...Full Text Available

1974-01-01

288

Radiopharmaceuticals for the imaging of functional abnormalities of the developing brain  

International Nuclear Information System (INIS)

The measurement of physiological parameters in man is possible with the help of positron emission tomography (PET) and radiopharmaceuticals labeled with short lived positron emitters as C 11, N 13, O 15 and F 18. With the use of this substances it is possible to make a tomographic map defining regional metabolic parameters in normal and diseased brain. This technique has therefore also be named 'in vivo autoradiography'. The possibility of applying C 11 or F 18 labeled deoxyglucose with PET for detecting regional and local changes in cerebral metabolic rate of glucose in brain development in children of 5 days to 1 year of age is discussed. Beyond this a relationship between cerebral metabolic rate of glucose, cerebral blood flow and cerebral metabolic rate of oxygen by use of this technique after inhalation of O 15 and C 11-labeled CO_2 is shown. Attention is drawn to the application of C ...

289

Protons and glucose metabolism in shock  

Energy Technology Data Exchange (ETDEWEB)

When oxygen is limiting, animals can ferment glucose via several metabolic pathways varying in energetic efficiency and leading to various end products (such as lactate, succinate, or propionate). Because the pH dependence of H/sup +/ production by fermentation is opposite to that by hydrolysis of adenosine triphosphate formed in the fermentation, the total number of moles of protons generated is always two per mole of fermentable substrate. However, two and three times more adenosine triphosphate can be turned over per mole of protons produced in succinate and propionate fermentations, respectively, than in lactate fermentation. At its limit, this advantage would achieve the same balance between H/sup +/ production and H/sup +/ consumption during ATP cycling that is observed in aerobic metabolism, a situation observed in certain alcohol fermentations. Since proton balance during anaerobiosis is clearly adaptable, we consider possible impact ...

1983-01-01

290

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation  

UK PubMed Central (United Kingdom)

The parathyroid hormone receptor (PTHR) is a class B G protein-coupled receptor that plays critical roles in bone and mineral ion metabolism. Ligand binding to the PTHR involves interactions to both...Full Text Available

2008-10-28

291

Proline Betaine Accumulation and Metabolism in Alfalfa Plants under Sodium Chloride Stress. Exploring Its Compartmentalization in Nodules1  

UK PubMed Central (United Kingdom)

The osmoprotectant Pro betaine is the main betaine identified in alfalfa (Medicago sativa). We have investigated the long-term responses of nodulated alfalfa plants to salt stress,...Full Text Available

2004-07-01

292

Plasminogen-125I responses in dogs to a single injection of urokinase and typhoid vaccine and to vascular injury  

UK PubMed Central (United Kingdom)

In vivo plasminogen responses to various stimuli were studied. Plasminogen-125I was prepared and used first for metabolic studies of plasminogen in control dogs. The average results were:...Full Text Available

1972-06-01

293

Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice  

UK PubMed Central (United Kingdom)

OBJECTIVENicotinamide adenine dinucleotides (NAD+ and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD+-to-NADH ratio is implicated...Full Text Available

2009-04-01

294

PGM2 overexpression improves anaerobic galactose fermentation in Saccharomyces cerevisiae  

UK PubMed Central (United Kingdom)

BackgroundIn Saccharomyces cerevisiae galactose is initially metabolized through the Leloir pathway after which glucose 6-phosphate enters glycolysis. Galactose...Full Text Available

295

PAS Domain Residues Involved in Signal Transduction by the Aer Redox Sensor of Escherichia coli  

UK PubMed Central (United Kingdom)

SummaryPAS domains sense oxygen, redox potential and light, and are implicated in behavior, circadian rhythmicity, development and metabolic regulation. Although PAS domains are...Full Text Available

2000-05-01

296

Opposing function of mitochondrial prohibitin in aging  

UK PubMed Central (United Kingdom)

While specific signalling cascades involved in aging, such as the insulin/IGF-1 pathway, are well-described, the actual metabolic changes they elicit to prolong lifespan remain obscure. Nevertheless,...Full Text Available

297

Novel Pathologic Findings Associated with Urinary Retention in a Mouse Model of Mucopolysaccharidosis Type IIIB  

UK PubMed Central (United Kingdom)

Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome type B) is a metabolic disorder with devastating clinical characteristics starting in early childhood and leading to premature death. A...Full Text Available

2009-04-01

298

Non-traumatic fractures following seizures: two case reports  

UK PubMed Central (United Kingdom)

IntroductionSeizures with or without trauma may cause fractures that occur commonly in epileptic seizures. Fracture risk is less reported in non-epileptic seizures. Some metabolic...Full Text Available

299

Near-infrared spectroscopy technique to evaluate the effects of red blood cell transfusion on tissue oxygenation  

UK PubMed Central (United Kingdom)

IntroductionThe aim of this study was to evaluate the effects of red blood cell (RBC) transfusions on muscle tissue oxygenation, oxygen metabolism and microvascular reactivity in...Full Text Available

2009-01-01

300

Near Infrared Dyes as Lifetime Solvatochromic Probes for Micropolarity Measurements of Biological Systems  

UK PubMed Central (United Kingdom)

The polarity of biological mediums controls a host of physiological processes such as digestion, signaling, transportation, metabolism, and excretion. With the recent widespread use of near-infrared...Full Text Available

2007-10-15

301

Natural variation in life history and aging phenotypes is associated with mitochondrial DNA deletion frequency in Caenorhabditis briggsae  

UK PubMed Central (United Kingdom)

BackgroundMutations that impair mitochondrial functioning are associated with a variety of metabolic and age-related disorders. A barrier to rigorous tests of the role of mitochondrial...Full Text Available

302

Morphological and metabolic responses to starvation by the dissimilatory metal-reducing bacterium Shewanella alga BrY.  

UK PubMed Central (United Kingdom)

The response of the dissimilatory metal-reducing bacterium Shewanella alga BrY to carbon and nitrogen starvation was examined. Starvation resulted in a gradual decrease in the mean cell volume from...Full Text Available

1996-12-01

303

Molecular mechanisms of genetic adaptation to xenobiotic compounds.  

UK PubMed Central (United Kingdom)

Microorganisms in the environment can often adapt to use xenobiotic chemicals as novel growth and energy substrates. Specialized enzyme systems and metabolic pathways for the degradation of man-made...Full Text Available

1992-12-01

304

Mitochondrial DNA Damage and Animal Longevity: Insights from Comparative Studies  

UK PubMed Central (United Kingdom)

Chemical reactions in living cells are under strict enzyme control and conform to a tightly regulated metabolic program. However, uncontrolled and potentially deleterious endogenous reactions occur,...Full Text Available

305

Metabolism of the benzidine-based azo dye Direct Black 38 by human intestinal microbiota.  

UK PubMed Central (United Kingdom)

Benzidine-based azo dyes are proven mutagens and have been linked to bladder cancer. Previous studies have indicated that their initial reduction is the result of the azo reductase activity of the intestinal...Full Text Available

1985-07-01

306

Metabolism of iodomethane in the rat  

UK PubMed Central (United Kingdom)

1. The LD50 of iodomethane orally administered to rats is 76mg./kg. body wt. but repeated daily doses of 30–50mg./kg. body wt. are without effect. 2. Oral doses of iodomethane to...Full Text Available

1966-01-01

307

Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation  

UK PubMed Central (United Kingdom)

Over the last three to four decades, it has been observed that the average total hours of sleep have decreased to less than seven hours per person per night. Concomitantly, global figures relating to...Full Text Available

308

Metabolic Engineering of Poly(3-Hydroxyalkanoates): From DNA to Plastic  

UK PubMed Central (United Kingdom)

Poly(3-hydroxyalkanoates) (PHAs) are a class of microbially produced polyesters that have potential applications as conventional plastics, specifically thermoplastic elastomers. A wealth of biological...Full Text Available

1999-03-01

309

Metabolic Engineering of Lactobacillus plantarum for Production of l-Ribulose?  

UK PubMed Central (United Kingdom)

l-Ribulose is a rare and expensive sugar that can be used as a precursor for the production of other rare sugars of high market value such as l-ribose. In this work we describe a production...Full Text Available

2007-11-01

310

Manganese  

Science.gov (United States)

Sources of manganese are identified. Uptake and distribution of manganese in plants and man are discussed, and the role of manganese in metabolism is described. The epidemiology of manganese toxicity is outlined, permissible air concentrations are listed, and the symptoms of manganese toxicity and deficiency are described. 555 references, 32 tables.

1973-01-01

311

Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance  

UK PubMed Central (United Kingdom)

Obesity and metabolic syndrome result from excess calorie intake and genetic predisposition and are mechanistically linked to type II diabetes and accelerated body aging; abnormal nutrient and insulin...Full Text Available

2010-07-27

312

Mammalian Sirtuins and Energy Metabolism  

UK PubMed Central (United Kingdom)

Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies....Full Text Available

313

Magnetic iron compounds in the human brain: a comparison of tumour and hippocampal tissue  

UK PubMed Central (United Kingdom)

Iron is a central element in the metabolism of normal and malignant cells. Abnormalities in iron and ferritin expression have been observed in many types of cancer. Interest in characterizing iron compounds...Full Text Available

2006-12-22

314

Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK  

UK PubMed Central (United Kingdom)

BackgroundMacrophages (MΦs) utilize macropinocytosis to integrate immune and metabolic signals in order to initiate an effective immune response. Diabetes is characterized...Full Text Available

315

METABOLIC EFFECTS OF ACUTE EXPOSURE TO METHOPRENE IN THE AMERICAN LOBSTER, HOMARUS AMERICANUS  

Science.gov (United States)

... hepatopancreas (1.55 ppm), gonad (5.18 ppm), epithelial tissue (6.17 ppm) and, most significantly, the eyestalks ( ... by Day 1 Stage I larvae and by epithelial tissue of postmolt juvenile lobsters. Postmo...

316

Long-lasting inhibition of presynaptic metabolism and neurotransmitter release by protein S-nitrosylation  

UK PubMed Central (United Kingdom)

Nitric oxide (NO) and related reactive nitrogen species (RNS) play a major role in the pathophysiology of stroke and other neurodegenerative diseases. One of the poorly understood consequences...Full Text Available

2010-09-01

317

Life Span Extension in Mice by Food Restriction Depends on an Energy Imbalance12  

UK PubMed Central (United Kingdom)

In this study, our main objective was to determine whether energy restriction (ER) affects the rate of oxygen consumption of mice transiently or lastingly and whether metabolic rate plays a role in...Full Text Available

2009-03-01

318

Lack of association between dietary fructose and hyperuricemia risk in adults  

UK PubMed Central (United Kingdom)

BackgroundHigh serum uric acid concentration (hyperuricemia) has been studied for its relationship with multiple adverse health outcomes, such as metabolic syndrome. Intervention...Full Text Available

319

Isoenzymes of Sugar Phosphate Metabolism in Endosperm of Germinating Castor Beans 1  

UK PubMed Central (United Kingdom)

Two isoenzymes each of phosphoglucomutase, hexose phosphate isomerase, aldolase, fructose diphosphatase, phosphofructokinase, and 6-phosphogluconate dehydrogenase have been separated by DEAE-cellulose...Full Text Available

1981-06-01

320

Iron Metabolism in the Anaemia of Chronic Renal Failure. Effects of Dialysis and of Pareuteral Iron  

UK PubMed Central (United Kingdom)

Serial studies of iron transport in patients on maintenance dialysis showed normal or raised values in almost all subjects and a transient increase soon after the start of dialysis in three. These...Full Text Available

1969-07-26

321

Interrelationships in trace-element metabolism in metal toxicities in a cobalt-resistant strain of Neurospora crassa  

UK PubMed Central (United Kingdom)

A strain of Neurospora crassa was isolated by training the mould to grow on media containing high concentrations of Co2+. This strain, the CoR strain, exhibited...Full Text Available

1973-04-01

322

Interleukin-7 mediates glucose utilization in lymphocytes through transcriptional regulation of the hexokinase II gene  

UK PubMed Central (United Kingdom)

The cytokine interleukin-7 (IL-7) has essential growth activities that maintain the homeostatic balance of the immune system. Little is known of the mechanism by which IL-7 signaling regulates metabolic...Full Text Available

2010-06-01

323

In Silico Atomic Tracing by Substrate-Product Relationships in Escherichia coli Intermediary Metabolism  

UK PubMed Central (United Kingdom)

We present a software system that computationally reproduces biochemical radioisotope-tracer experiments. It consists of three main components: A mapping database of substrate-product atomic correspondents...Full Text Available

2003-11-01

324

Identification of Potential Calorie Restriction-Mimicking Yeast Mutants with Increased Mitochondrial Respiratory Chain and Nitric Oxide Levels  

UK PubMed Central (United Kingdom)

Calorie restriction (CR) induces a metabolic shift towards mitochondrial respiration; however, molecular mechanisms underlying CR remain unclear. Recent studies suggest that CR-induced mitochondrial...Full Text Available

325

Identification and Characterization of Retinoid-Active Short-Chain Dehydrogenases/Reductases in Drosophila melanogaster  

UK PubMed Central (United Kingdom)

BackgroundIn chordates, retinoid metabolism is an important target of short-chain dehydrogenases/reductases (SDRs). It is not known whether SDRs play a role in retinoid...Full Text Available

2009-10-01

326

Growth and Energy Generation by Lactococcus lactis subsp. lactis biovar diacetylactis during Citrate Metabolism  

UK PubMed Central (United Kingdom)

Growth of Lactococcus lactis subsp. lactis biovar diacetylactis was observed on media with citrate as the only energy source. At pH 5.6, steady state was achieved in...Full Text Available

1993-12-01

327

Functional pools of oxidative and glycolytic fibers in human muscle observed by 31P magnetic resonance spectroscopy during exercise.  

UK PubMed Central (United Kingdom)

Quantitative probing of heterogeneous regions in muscle is feasible with phosphorus-31 magnetic resonance spectroscopy because of the differentiation of metabolic patterns of glycolytic and oxidative...Full Text Available

1987-12-01

328

Fatty Acid- and Retinoid-binding Proteins Have Distinct Binding Pockets for the Two Types of Cargo*  

UK PubMed Central (United Kingdom)

Parasitic nematodes cause serious diseases in humans, animals, and plants. They have limited lipid metabolism and are reliant on lipid-binding proteins to acquire these metabolites from their hosts....Full Text Available

2009-12-18

329

Expression of a coriander desaturase results in petroselinic acid production in transgenic tobacco.  

UK PubMed Central (United Kingdom)

Little is known about the metabolic origin of petroselinic acid (18:1 delta 6cis), the principal fatty acid of the seed oil of most Umbelliferae, Araliaceae, and Garryaceae species. To examine the possibility...Full Text Available

1992-12-01

330

Exploring the Temperature-Stress Metabolome of Arabidopsis1[w  

UK PubMed Central (United Kingdom)

Metabolic profiling analyses were performed to determine metabolite temporal dynamics associated with the induction of acquired thermotolerance in response to heat shock and acquired freezing tolerance...Full Text Available

2004-12-01

331

Enzymic Capacities of Purified Cauliflower Bud Plastids for Lipid Synthesis and Carbohydrate Metabolism 1  

UK PubMed Central (United Kingdom)

Isolated cauliflower (Brassica oleracea) bud plastids, purified by isopycnic centrifugation in density gradients of Percoll, were found to be highly intact, to be practically devoid...Full Text Available

1985-10-01

332

Enhanced Levels of the Aroma and Flavor Compound S-Linalool by Metabolic Engineering of the Terpenoid Pathway in Tomato Fruits1  

UK PubMed Central (United Kingdom)

The aromas of fruits, vegetables, and flowers are mixtures of volatile metabolites, often present in parts per billion levels or less. We show here that tomato (Lycopersicon esculentum...Full Text Available

2001-11-01

333

Elevated BMI Is Associated With Decreased Blood Flow in the Prefrontal Cortex Using SPECT Imaging in Healthy Adults  

UK PubMed Central (United Kingdom)

Obesity is a risk factor for stroke and neurodegenerative disease. Excess body fat has been linked to impaired glucose metabolism, insulin resistance, and impulsivity and may be a precursor to decline...Full Text Available

2011-05-01

334

Efficient preparation of internally modified single-molecule constructs using nicking enzymes  

UK PubMed Central (United Kingdom)

Investigations of enzymes involved in DNA metabolism have strongly benefited from the establishment of single molecule techniques. These experiments frequently require elaborate DNA substrates, which...Full Text Available

2011-02-01

335

Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes  

UK PubMed Central (United Kingdom)

Bitter orange (Citrus aurantium) extract is widely used in dietary supplements for weight management and sports performance. Its primary protoalkaloid is p-synephrine....Full Text Available

336

Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin  

UK PubMed Central (United Kingdom)

Mice lacking acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), an enzyme that catalyzes the terminal step in triacylglycerol synthesis, have enhanced insulin sensitivity and are protected from...Full Text Available

2006-08-01

337

Effects of Cycling Temperatures on Fiber Metabolism in Cultured Cotton Ovules 1  

UK PubMed Central (United Kingdom)

The effects of temperature on rates of cellulose synthesis, respiration, and long-term glucose uptake were investigated using cultured cotton ovules (Gossypium hirsutum L. cv Acala...Full Text Available

1992-10-01

338

Effect of long-term caloric restriction on oxygen consumption and body temperature in two different strains of mice  

UK PubMed Central (United Kingdom)

The hypothesis, that a decrease in metabolic rate mediates the life span prolonging effect of caloric restriction (CR), was tested using two strains of mice, one of which, C57BL/6, exhibits...Full Text Available

2007-10-01

339

Effect of Leucovorin (Folinic Acid) on the Developmental Quotient of Children with Down's Syndrome (Trisomy 21) and Influence of Thyroid Status  

UK PubMed Central (United Kingdom)

BackgroundSeven genes involved in folate metabolism are located on chromosome 21. Previous studies have shown that folate deficiency may contribute to mental retardation in Down's...Full Text Available

340

Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics*  

UK PubMed Central (United Kingdom)

Increasing attention is being paid to the scientific evaluation of traditional Chinese medicine (TCM). As many TCMs are capable of biotransformation in the gastrointestinal tract, attention to biotransformation...Full Text Available

2006-02-01

341

Dynamic body weight and body composition changes in response to subordination stress  

UK PubMed Central (United Kingdom)

Social stress is prevalent in many facets of modern society. Epidemiological data suggest that stress is linked to the development of overweight, obesity and metabolic disease. Although there...Full Text Available

2007-07-24

342

Diversity of Microbial Sialic Acid Metabolism  

UK PubMed Central (United Kingdom)

Sialic acids are structurally unique nine-carbon keto sugars occupying the interface between the host and commensal or pathogenic microorganisms. An important function of host sialic acid is to regulate...Full Text Available

2004-03-01

343

Dissolved Hydrocarbons and Related Microflora in a Fjordal Seaport: Sources, Sinks, Concentrations, and Kinetics  

UK PubMed Central (United Kingdom)

The continuous addition of toluene as a solute of treated ballast water from oil tankers into a well-defined estuary facilitated the study of the dynamics of dissolved hydrocarbon metabolism in seawater....Full Text Available

1981-10-01

344

Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae.  

UK PubMed Central (United Kingdom)

We have isolated a second gene (MLS1), which in addition to DAL7, encodes malate synthase from S. cerevisiae. Expression of the two genes is specific for their physiological roles in carbon and nitrogen...Full Text Available

1992-11-11

345

Developmental and metabolic regulation of the Drosophila melanogaster 3-hydroxy-3-methylglutaryl coenzyme A reductase.  

UK PubMed Central (United Kingdom)

The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase in Drosophila melanogaster synthesizes mevalonate for the production of nonsterol isoprenoids, which are essential for growth and...Full Text Available

1988-07-01

346

Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of Legionella pneumophila  

UK PubMed Central (United Kingdom)

Proteins that metabolize or bind the nucleotide second messenger cyclic diguanylate regulate a wide variety of important processes in bacteria. These processes include motility, biofilm formation, cell...Full Text Available

347

Creatine and Phosphocreatine: A Review of Their Use in Exercise and Sport  

UK PubMed Central (United Kingdom)

Objective: Creatine and phosphocreatine (PCr) are important compounds in the normal energy metabolism of muscle. Recently, it has been shown that dietary creatine (5 to 20 g/day)...Full Text Available

1997-01-01

348

Crassulacean Acid Metabolism and Epiphytism Linked to Adaptive Radiations in the Orchidaceae1[OA  

UK PubMed Central (United Kingdom)

Species of the large family Orchidaceae display a spectacular array of adaptations and rapid speciations that are linked to several innovative features, including specialized pollination syndromes,...Full Text Available

2009-04-01

349

Continuous monitoring of receptor-mediated changes in the metabolic rates of living cells.  

UK PubMed Central (United Kingdom)

Activation of beta-adrenergic or muscarinic acetylcholine receptors expressed in transfected cells or epidermal growth factor receptors in human keratinocytes produces 15% to 200% changes in cellular...Full Text Available

1990-05-01

350

Consequences of Low Neonatal Iron Status due to Maternal Diabetes Mellitus on Explicit Memory Performance in Childhood  

UK PubMed Central (United Kingdom)

Diabetic pregnancies are characterized by chronic metabolic insults, including iron deficiency, that place the developing brain at risk and for memory impairment later in life. A behavioral...Full Text Available

2009-11-01

351

Comparison of the Survival and Metabolic Activity of Psychrophilic and Mesophilic Yeasts Subjected to Freeze-Thaw Stress  

UK PubMed Central (United Kingdom)

A mesophilic yeast, Candida utilis, and a psychrophilic yeast, Leucosporidium stokesii, were subjected to freeze-thaw cycling over the range 25 to -60 C. Viability...Full Text Available

1975-06-01

352

Comparing and Contrasting the Roles of AMPK and SIRT1 in Metabolic Tissues  

UK PubMed Central (United Kingdom)

The ability to adapt and respond to nutrients is an ancient cellular function, conserved from unicellular to the most complex multicellular organisms, including mammals. Mammals adapt to changes...Full Text Available

2008-12-01

353

Comparative transcripts profiling reveals new insight into molecular processes regulating lycopene accumulation in a sweet orange (Citrus sinensis) red-flesh mutant  

UK PubMed Central (United Kingdom)

BackgroundInterest in lycopene metabolism and regulation is growing rapidly because accumulative studies have suggested an important role for lycopene in human health promotion....Full Text Available

354

Comparative aspects of pesticide metabolism in plants and animals.  

UK PubMed Central (United Kingdom)

Pesticide chemicals are an important component of modern agriculture. Through their use, plants and animals are exposed to pesticides directly and indirectly from transport through soil, water, and...Full Text Available

1978-12-01

355

Citrate Uptake in Exchange with Intermediates in the Citrate Metabolic Pathway in Lactococcus lactis IL1403?  

UK PubMed Central (United Kingdom)

Carbohydrate/citrate cometabolism in Lactococcus lactis results in the formation of the flavor compound acetoin. Resting cells of strain IL1403(pFL3) rapidly consumed citrate while...Full Text Available

2011-02-01

356

Circadian Disruption and Metabolic Disease: Findings from Animal Models  

UK PubMed Central (United Kingdom)

Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors...Full Text Available

2010-10-01

357

Cell-density-dependent Changes in the Metabolism of Chloronema Cell Cultures  

UK PubMed Central (United Kingdom)

In the growing chloronema cell suspension cultures of the moss Funaria hygrometrica Hedw., activities of several enzymes have been found to be cell-density-dependent. Cyclic nucleotide...Full Text Available

1979-07-01

358

Cancer Risk in Type 2 Diabetes Mellitus: Metabolic Links and Therapeutic Considerations  

UK PubMed Central (United Kingdom)

Type 2 diabetes mellitus (DM2) is increasing in incidence, creating worldwide public health concerns and impacting morbidity and mortality rates. An increasing number of studies have demonstrated shared...Full Text Available

2011-01-01

360

Betaxanthins as Substrates for Tyrosinase. An Approach to the Role of Tyrosinase in the Biosynthetic Pathway of Betalains1  

UK PubMed Central (United Kingdom)

Tyrosinase or polyphenol oxidase (EC 1.14.18.1) is the key enzyme in melanin biosynthesis and in the enzymatic browning of fruits and vegetables. The role of tyrosinase in the secondary metabolism of...Full Text Available

2005-05-01

361

Auxin-Induced Ethylene Production as Related to Auxin Metabolism in Leaf Discs of Tobacco and Sugar Beet 1  

UK PubMed Central (United Kingdom)

Exogenously supplied indole-3-acetic acid (IAA) stimulated ethylene production in tobacco (Nicotiana glauca) leaf discs but not in those of sugar beet (Beta vulgaris...Full Text Available

1983-11-01

362

Age- and Gender-Related Differences in the Geometric Properties and Biomechanical Significance of Intracortical Porosity in the Distal Radius and Tibia  

UK PubMed Central (United Kingdom)

Cortical bone contributes the majority of overall bone mass and bears the bulk of axial loads in the peripheral skeleton. Bone metabolic disorders often are manifested by cortical microstructural changes...Full Text Available

2010-05-01

363

Adipose Tissue Gene Expression of Factors Related to Lipid Processing in Obesity  

UK PubMed Central (United Kingdom)

BackgroundAdipose tissue lipid storage and processing capacity can be a key factor for obesity-related metabolic disorders such as insulin resistance and diabetes. Lipid uptake is...Full Text Available

364

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis*  

UK PubMed Central (United Kingdom)

Adipocyte death has been reported in both obese humans and rodents. However, its role in metabolic disorders, including insulin resistance, hepatic steatosis, and inflammation associated with obesity...Full Text Available

2010-01-29

365

Ab binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism  

UK PubMed Central (United Kingdom)

Abs facilitate humoral immunity via the classical mechanisms of opsonization, complement activation, Ab-dependent cellular cytotoxicity, and toxin/viral neutralization. There is also evidence that some...Full Text Available

2010-04-01

366

AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of ?-catenin at Ser 552  

UK PubMed Central (United Kingdom)

AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism; its activity is regulated by a plethora of physiological conditions, exercises and many anti-diabetic drugs. Recent...Full Text Available

2010-04-23

367

A small RNA promotes siderophore production through transcriptional and metabolic remodeling  

UK PubMed Central (United Kingdom)

Siderophores are essential factors for iron (Fe) acquisition in bacteria during colonization and infection of eukaryotic hosts, which restrain iron access through iron-binding protein, such as lactoferrin...Full Text Available

2010-08-24

368

A novel fluorescent pH probe for expression in plants  

UK PubMed Central (United Kingdom)

BackgroundThe pH is an important parameter controlling many metabolic and signalling pathways in living cells. Recombinant fluorescent pH indicators (pHluorins) have come into vogue...Full Text Available

369

A direct role for serum albumin in the cellular uptake of long-chain fatty acids.  

UK PubMed Central (United Kingdom)

The interaction of long-chain fatty acids with cells is important for their uptake and metabolism, as well as their involvement in signalling processes. The majority of long-chain fatty acids circulating...Full Text Available

1995-05-15

370

A comparative analysis of phenylpropanoid metabolism, N utilization, and carbon partitioning in fast- and slow-growing Populus hybrid clones  

UK PubMed Central (United Kingdom)

The biosynthetic costs of phenylpropanoid-derived condensed tannins (CTs) and phenolic glycosides (PGs) are substantial. However, despite reports of negative correlations between leaf phenolic content...Full Text Available

2009-08-01

371

A Comparison between Quin-2 and Aequorin as Indicators of Cytoplasmic Calcium Levels in Higher Plant Cell Protoplasts 1  

UK PubMed Central (United Kingdom)

Assessment of the regulation of plant metabolism by the calcium ion requires a knowledge of its intracellular levels and dynamics. Technical problems have prevented direct measurement of the concentration...Full Text Available

1989-06-01

372

1,3-Butadiene: linking metabolism, dosimetry, and mutation induction.  

UK PubMed Central (United Kingdom)

There is increasing concern for the potential adverse health effects of human exposures to chemical mixtures. To better understand the complex interactions of chemicals within a mixture, it is essential...Full Text Available

1994-11-01

373

Using tree swallows to monitor impacts of aquatic contamination in Great Lakes areas of concern  

Energy Technology Data Exchange (ETDEWEB)

Tree swallows were used to evaluate movement and potential impacts of contaminants from sediments in Newton Creek (diesel range organics: DROs) and Sheboygan River (PCBs), tributaries to Lake Superior and Lake Michigan, respectively. Contaminated sites occurred along the course of each river, while reference sites were located upstream or on a nearby river. Productivity was monitored and eggs, day 1 nestlings, and day 12 nestlings were collected from each nest. Whole body or egg homogenates were analyzed for PCBs or DROs. EROD activity in livers from day 12 nestlings is being determined for both PCB and DRO exposures. In the Newton Creek study, hatching success was similar for DRO and reference sites. DROs were detected in gastrointestinal tracts of 1 nestling from the reference and 1 from the contaminated site. DROs were not detected in any egg samples. In the Sheboygan River study, hatching success rates differed between 1 reference and 1 ...

1995-12-31

374

Radioactivity in sediments of the Great Lakes: post-depositional redistribution by deposit-feeding organisms  

International Nuclear Information System (INIS)

At two locations in southern Lake Huron (U.S.A.), twelve 35.5-cm diameter cores of fine-grained sediments were taken for comparison of the vertical distribution of "2"1"0Pb and fallout "1"3"7Cs with the distribution of benthic macroinvertebrates, mainly oligochaete worms (Tubificidae) and the amphipod, Pontoporeia affinis. Locations were selected on the basis of "2"1"0Pb distributions measured a year earlier which indicated contrasting depths of mixing of surface sediments. At one location the activity of "2"1"0Pb is uniform down to about 6 cm and 95% of total invertebrates occur within this zone; at the other location the zone of constant activity is only 3 cm deep but 90% of the invertebrates occur within it. Comparison of published tubificid defecation rates with sediment accumulation rates based on "2"1"0Pb shows that oligochaetes alone can account for mixing in one case while the effects of amphipods may be required in the case of shallower mixing. If mixing ...

375

Kokanee Stock Status and Contribution of Cabinet Gorge Hatchery, Lake Pend Oreille, Idaho, 1986 Annual Progress Report.  

Energy Technology Data Exchange (ETDEWEB)

Estimated kokanee (Oncorhynchus nerka) abundance in Lake Pend Oreille was 4.3 million during September 1986. This estimate was similar to 1985 and indicates continued suppression of the kokanee population since initial decline in the late 1960s. Atypically high survival of wild fry resulted in similar fry recruitment in 1986 as 1985, whereas hatchery-reared fry contributed only 8% to total fry recruitment as a result of low post-release survival (3%). Fry released into the Clark Fork River from Cabinet Gorge Hatchery had very low survival during emigration to Lake Pend Oreille, resulting from poor flow conditions and potentially high predation. Fry survival during emigration was twice as high during nighttime flows of 16,000 cfs than 7,800 cfs. Emigration also was faster during higher flows. Several marks were tested to differentially mark fry release groups to help determine impacts of flow and other factors on fry survival. Survival of fry ...

1987-02-01

376

Geology of 1. 7 GA ( ) Baldwin gneiss in the Baldwin Lake type area, San Bernardino Mountains, southern California  

Science.gov (United States)

Precambrian gneisses in the San Bernardino Mountains were first identified and described in the vicinity of Baldwin Lake by Guillou (1953). Five lithologic units mappable at 1:24,000 scale are recognized: biotite [+-] muscovite quartzofeldspathic gneiss, amphibolite, pyroxene metagabbro, augen gneiss, and biotite [+-] muscovite granitic gneiss. Baldwin gneiss with this L Baldwin Lake, the gneissic fabric is rotated toward the northwest, subparallel to the Doble fault. Along this fault, Baldwin gneiss is structurally underlain by overturned Paleozoic quartzite and marble (Zabriskie Quartzite and Carrara Formation). Regional relations suggest that the Doble fault is a northeast-directed basement thrust fault of pre-Late Cretaceous age, and may be contemporaneous with late Paleozoic deformation and metamorphism of Paleozoic rocks further west in the range. Field relations suggest that Baldwin gneiss in its type area largely retains Proterozoic ...

1993-04-01

377

Evaluation of potential hydrocarbon sources in lacustrine facies of Newark Supergroup, eastern United States  

Energy Technology Data Exchange (ETDEWEB)

Lacustrine rocks are a significant component of many rift-valley sequences. Comparisons of both active and ancient rift valleys indicate that the lacustrine facies are commonly rich in organic matter and may be important sources for oil. For example, Holocene sediments in Lake Tanganyika and Cretaceous lacustrine rocks in west Africa contain as much as 12% and 20% TOC, respectively. The Newark Supergroup contains abundant lacustrine rocks. The widespread occurrence of black shales, the general similarity to known organically rich rift systems, and a few isolated geochemical analyses have caused some speculation about the potential of the Newark Supergroup to be an effective source of oil and gas. Sufficient geochemical analyses are available from lacustrine rocks in the Newark, Connecticut, and Deep River basins to evaluate their potential as hydrocarbon sources. In general, both the quantity and quality of organic matter in these rocks are less than that required ...

1985-02-01

378

PET/CT cardiology: an area whose boundaries are still out of sight  

International Nuclear Information System (INIS)

Positron emission tomography (PET) and X-ray computed tomography (CT) performed with PET/CT cameras allow us to obtain concurrently information on the presence and degree of alterations of myocardial perfusion and metabolism and on coronary arteries calcification. Furthermore, by gated myocardial perfusion studies, PET may provide crucial information on regional coronary blood flow reserve and endothelial dysfunction. A number of recent papers provide some insight on the potential of PET/CT in cardiology and in the assessment of various cardiovascular diseases including various types of vasculitis and metabolic diseases.

2006-05-01

379

Nutrition and Physical Activity in Aging, Obesity, and Cancer  

British Library Electronic Table of Contents (United Kingdom)

The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH-STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH-STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH-STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.

2011-01-01

380

Microbiological Transformations of Radionuclides in the Subsurface  

Energy Technology Data Exchange (ETDEWEB)

Microorganisms are ubiquitous in subsurface environments although their populations sizes and metabolic activities can vary considerably depending on energy and nutrient inputs. As a result of their metabolic activities and the chemical properties of their cell surfaces and the exopolymers they produce, microorganisms can directly or indirectly facilitate the biotransformation of radionuclides, thus altering their solubility and overall fate and transport in the environment. Although biosorption to cell surfaces and exopolymers can be an important factor modifying the solubility of some radionuclides under specific conditions, oxidation state is often considered the single most important factor controlling their speciation and, therefore, environmental behavior.

2010-01-04

381

Influence of anaerobic microbial activity on biosorption of 2,4-dichlorophenol  

Energy Technology Data Exchange (ETDEWEB)

Biosorption is an important removal mechanism in treating hydrophobic toxic organics in biological reactors. Equilibrium sorption isotherms and sorption kinetics of 2,4-dichlorophenol on live and chemically inactive anaerobic granules were studied. A metabolic inhibitor was used to inactivate the biological activity of the biomass. Results showed that the difference in the biosorption of live and chemically inactive anaerobic granules is not significant. This would suggest that anaerobic biosorption is mainly a physical-chemical process and that metabolic-mediated diffusion in the process is negligible. 12 refs., 3 tabs., 7 figs.

1995-12-31

382

In vivo recovery of glycogen metabolism in hemolymph and tissues of a freshwater field crab Barytelphusa guerini on exposure to hexavalent chromium  

Energy Technology Data Exchange (ETDEWEB)

The in vivo toxic effects of hexavalent chromium (20 mg/liter) on hemolymph glucose, tissue glycogen, total free sugars, and active and total phosphorylases of an edible, freshwater crab Barytelphusa guerini were studied. In a 15-day exposure span followed by a 15-day postexposure recovery, the time-course alterations in these constituent segments of the glycogen metabolism indicate an inconsistent depletion in metabolite levels and elevated enzyme activities during exposure period as well as hyperglycemia. An insignificant recovery was observed in these parameters on the 15th day of the postexposure phase.

1990-08-01

383

Fluoride induced changes in protein metabolism in the tissues of freshwater crab Barytelphusa guerini.  

Science.gov (United States)

Exposure of the freshwater field crab Barytelphusa guerini to a sublethal concentration of NaF (30 mg litre(-1)) caused significant alterations in protein metabolism. After an exposure time of 15 days, the crab was found to have a marked depletion of total protein and free amino acid content. A significant elevation in transaminases, Aspartate aminotransferase (AAT) and Alanine aminotransferase (ALAT), and Glutamate dehydrogenase (GDH) activities was reflected in the free amino acid levels of the tissues. PMID:15092215

1990-01-01

384

Effect of protein malnutrition on the metabolism of bone collagen in albino rats  

International Nuclear Information System (INIS)

The effect of protein malnutrition on the metabolism of collagen in bone was studied in young female albino rats after a single injection of "3H-proline. Both specific and total radioactivities of hydroxyproline in the total collagen of the bone were found to decrease in the protein-deficient animals, indicating decreased rate of collagen synthesis. In the urine the amount of hydroxyproline excreted and total radioactivity of "3H-hydroxyproline were greatly decreased. The results of the present investigation therefore clearly indicate decreased synthesis and catabolism of collagen in bones of protein deficient animals compared to controls. (auth.).

1981-01-01

385

Effect of repeated benzene inhalation exposures on benzene metabolism, binding to hemoglobin, and induction of micronuclei  

International Nuclear Information System (INIS)

Metabolism of benzene is thought to be necessary to produce the toxic effects, including carcinogenicity, associated with benzene exposure. To extrapolate from the results of rodent studies to potential health risks in man, one must know how benzene metabolism is affected by species, dose, dose rate, and repeated versus single exposures. The purpose of our studies was to determine the effect of repeated inhalation exposures on the metabolism of [14C]benzene by rodents. Benzene metabolism was assessed by characterizing and quantitating urinary metabolites, and by quantitating 14C bound to hemoglobin and micronuclei induction. F344/N rats and B6C3F1 mice were exposed, nose-only, to 600 ppm benzene or to air (control) for 6 hr/day, 5 days/week for 3 weeks. On the last day, both benzene-pretreated and control animals were exposed to 600 ppm, 14C-labeled benzene for 6 hr. Individual benzene metabolites in ...

386

Modelling transport of water and solutes in future wetlands in Forsmark  

Energy Technology Data Exchange (ETDEWEB)

The Forsmark area consists of a number of natural wetlands. As a part of the evaluation of wetlands in the safety assessment for the area, possible future wetlands are being studied with respect to hydrology and transport mechanisms. A sensitivity analyses is performed to point out the governing parameters for the wetland hydraulics. The analysis of future wetlands is carried out using the hydrological model system Mike SHE. Mike SHE has been used to describe the near-surface hydrology for a regional model area in Forsmark. Three types of areas have been chosen. Today's lake Bolundfjaerden is because of its shallow depth likely to develop into a mire in the future. As it is situated in the downstream part of the regional model area, the runoff to the lake from upstream surface water system is significant. Lake Eckarfjaerden is situated in the upstream part of the catchment at a higher altitude and with a smaller ...

2006-03-15

387

The influence of melatonin on metabolic changes in female rats induced by continuous irradiation and/or administration of 7,12-dimethylbenz/a/anthracene  

International Nuclear Information System (INIS)

Metabolic profile is an important biological marker of neoplastic processes not only in the tumor itself but also in the host organism. The neuro-hormone melatonin has been implicated in the experiments as an oncostatic agent. Female Wistar:Han SPF rats (Velaz, Prague, Czech Republic) were irradiated continuously for 15 days using a daily gamma rays dose of 96 mGy. At the end of exposure one group of rats was administered 5 mg/kg b.w. of dimethylbenz/a/anthracene (DMBA) intragastrically. During the period of exposure to ionizing radiation a part of the animals was supplied with melatonin (M) at a concentration of 20 #mu#l/ml in drinking water. Selected parameters of lipid and carbohydrate metabolism and levels of selected hormones were determined 2, 30 and 100 days post-irradiation. The irradiation itself caused only small changes in tissue lipids. The application of a single low dose (subthreshold from the point of view of induction of mammary ...

388

Pathophysiology of incomplete renal tubular acidosis in recurrent renal stone formers: evidence of disturbed calcium, bone and citrate metabolism  

DEFF Research Database (Denmark)

Urinary acidification, bone metabolism and urinary excretion of calcium and citrate were evaluated in 10 recurrent stone formers with incomplete renal tubular acidosis (iRTA), 10 recurrent stone formers with normal urinary acidification (NUA) and 10 normal controls (NC). Patients with iRTA had lower plasma standard bicarbonate after fasting (P <0.01) and lower urinary excretion of titratable acid (P <0.05) and citrate (P <0.01) compared with NUA patients and NC, and higher urinary excretion of ammonia (P <0.05) compared with NC (P <0.05). Hypercalciuria was found in 6 of 10 patients with iRTA compared with 3 of 10 with NUA, and 0 of 10 NC. The citrate/calcium ratio in urine was significantly reduced in iRTA compared with the value in NUA (P <0.01), and in NUA compared with NC (P <0.05). Biochemical markers of bone formation (serum osteocalcin) and bone resorption (urinary hydroxyproline) were significantly increased in iRTA compared with NUA ...

1993-01-01

389

Influence of solar activity and environment on 10Be in recent natural archives  

Energy Technology Data Exchange (ETDEWEB)

Understanding the link between the Sun and climate is vital in the current incidence of global climate change, and 10Be in natural archives constitutes an excellent tracer for this purpose. As cosmic rays enter the atmosphere, cosmogenic isotopes like 10Be and 14C are formed. Variations in solar activity modulate the amount of incoming cosmic rays, and thereby cosmogenic isotope production. Atmospherically produced 10Be enters natural archives such as sediments and glaciers by wet and dry deposition within about a year of production. 10Be from natural archives therefore provides information on past solar activity, and because these archives also contain climate information, solar activity and climate can be linked. One remaining question is to what degree 10Be in natural archives reflects production, and to what extent the local and regional environment overprints the production signal. To explore this, 10Be was measured at annual resolution over the last 600 years in a Greenland ice ...

2009-05-15

390

[Fe]-hydrogenases in green algae: photo-fermentation and hydrogen evolution under sulfur deprivation  

Energy Technology Data Exchange (ETDEWEB)

Recent studies indicate that [Fe]-hydrogenases and H{sub 2} metabolism are widely distributed among green algae. The enzymes are simple structured and catalyze H{sub 2} evolution with similar rates than the more complex [Fe]-hydrogenases from bacteria. Different green algal species developed diverse strategies to survive under sulfur deprivation. Chlamydomonas reinhardtii evolves large quantities of hydrogen gas in the absence of sulfur. In a sealed culture of C. reinhardtii, the photosynthetic O{sub 2} evolution rate drops below the rate of respiratory O{sub 2} consumption due to a reversible inhibition of photosystem II, thus leading to an intracellular anaerobiosis. The algal cells survive under these anaerobic conditions by switching their metabolism to a kind of photo-fermentation. Although possessing a functional [Fe]-hydrogenase gene, the cells of Scenedesmus obliquus produce no significant amounts of H{sub 2} under S-depleted ...

2002-12-01

391

Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin  

British Library Electronic Table of Contents (United Kingdom)

Estrogen metabolism is suggested to play an important role in estrogen-induced breast carcinogenesis. Epidemiologic studies suggest that diets rich in phytoestrogens are associated with a reduced risk of breast cancer. Phytoestrogens are biologically active plant compounds that structurally mimic 17b-estradiol (E2). We hypothesize that phytoestrogens, may provide protection against breast carcinogenesis by altering the expression of estrogen-metabolizing enzymes cytochrome P450 1A1 (Cyp1A1) and 1B1 (Cyp1B1). Cyp1A1 and Cyp1B1 are responsible for the metabolism of E2 to generate 2-hydroxyestradiol (2-OHE2) and 4-hydroxyestradiol (4-OHE2), respectively. Studies suggest that 2-OHE2 and 2-methoxyestradiol may protect against breast carcinogenesis, while 4-OHE2 is carcinogenic in rodent models....

2008-01-01

392

GAMMA GLOBULIN METABOLISM IN RABBITS DURING THE ANAMNESTIC RESPONSE.  

Science.gov (United States)

1. Gamma globulin metabolism and distribution were studied employing rabbit gamma globulin (RGG)I(131) 24 times in 13 control rabbits. Similar studies were performed before and during the ananmestic response in 4 rabbits previously sensitized with a polyvalent pneumococcal vaccine. 2. During the ananmestic response, gamma-globulin levels increased from 1.0 to 6.0 gm/100 ml, and the gamma-globulin pool increased from 0.7 to 4.7 gm/kg. There was no change in the intravascular-extravascular partition of gamma globulin. 3. Gamma globulin degradation increased from 0.06 to 0.33 gm/kg/day during the 28 days of the immunization period while gamma globulin synthesis increased even further to average 0.47 gm/kg/day. Following the attainment of elevated gamma globulin levels the fractional rate of RGG-I(131) turnover increased from 8.0 to 12.5 per cent/day. 4. No differences were noted in the metabolism of homologous or autologous gamma globulin ...

1964-04-01

393

Control of microbially generated hydrogen sulfide in produced waters  

Energy Technology Data Exchange (ETDEWEB)

Production of hydrogen sulfide in produced waters due to the activity of sulfate-reducing bacteria (SRB) is a potentially serious problem. The hydrogen sulfide is not only a safety and environmental concern, it also contributes to corrosion, solids formation, a reduction in produced oil and gas values, and limitations on water discharge. Waters produced from seawater-flooded reservoirs typically contain all of the nutrients required to support SRB metabolism. Surface processing facilities provide a favorable environment in which SRB flourish, converting water-borne nutrients into biomass and H{sub 2}S. This paper will present results from a field trial in which a new technology for the biochemical control of SRB metabolism was successfully applied. A slip stream of water downstream of separators on a produced water handling facility was routed through a bioreactor in a side-steam device where microbial growth was allowed to develop fully. This ...

1995-12-31

394

Understanding consumption-related sucralose emissions - A conceptual approach combining substance-flow analysis with sampling analysis  

British Library Electronic Table of Contents (United Kingdom)

This paper explores the potential of combining substance-flow modelling with water and wastewater sampling to trace consumption-related substances emitted through the urban wastewater. The method is exemplified on sucralose. Sucralose is a chemical sweetener that is 600 times sweeter than sucrose and has been on the European market since 2004. As a food additive, sucralose has recently increased in usage in a number of foods, such as soft drinks, dairy products, candy and several dietary products. In a field campaign, sucralose concentrations were measured in the inflow and outflow of the local wastewater treatment plant in Linkoping, Sweden, as well as upstream and downstream of the receiving stream and in Lake Roxen. This allows the loads emitted from the city to be estimated. A method c...

2010-01-01

395

Shallow-lacustrine sand-rich deltaic depositional cycles and sequence stratigraphy of the Upper Triassic Yanchang Formation, Ordos Basin, China  

British Library Electronic Table of Contents (United Kingdom)

ABSTRACT Shallow-lacustrine delta deposits of the Upper Triassic Yanchang Formation form the most important petroleum reservoir sandstone units in the Ordos Basin, China. Recent hydrocarbon exploration and outcrop studies demonstrated that shallow-lacustrine sand-rich deltas developed extensively along the gentle flanks and central part of the basin. The vertical succession of facies indicates that the Yanchang Formation records the entire lacustrine life cycle of the Late Triassic Ordos Basin. Four third-order transgressive-regressive cycles and two larger shallow-lacustrine deltaic cycles have been recognized. A process-based depositional model, derived in part from the modern Ganjiang delta in Poyang Lake, China, is used to infer the origins of the sand-rich lacustrine delta deposits. S...

2010-01-01

396

Remote sensing; Fernerkundung  

Energy Technology Data Exchange (ETDEWEB)

The potential of different multitemporal and multispectral airborne and spaceborne remote sensing methods for assessment and monitoring of the lignite open-cast mining areas are discussed in this chapter. Emphasis is placed on the successful use of different remote sensing data in variable vegetation structures for dumped sediments with different mineralogical and geochemical properties and for hydrochemical properties of the residual lakes. Multiple remote sensing data are a cost and time efficient tool for the assessment of environmental impacts, supervising of reclamation activities as well as for long term monitoring of the mining area. The airborne data are well suited for large scale detailed research and mapping in smaller sites and the satellite data for the overview scale 1:50 000. An integrated remote sensing-GIS-system including all field and lab data, DTM and other graphical data, improve the results of the remote sensing data classification for the ...

2001-07-01

397

Quantification and reduction of the uncertainty in mass balance models by Monte Carlo analysis of prior data  

Energy Technology Data Exchange (ETDEWEB)

The general objective of this workshop is to investigate and discuss methods by which uncertainties in mass balance models for toxics in the Great Lakes may be reduced. As described by the workshop prospectus, this paper is focused on problems of reducing (and quantifying) uncertainty as they relate to in situ field observations/system response measurements for the establishment of initial conditions, boundary conditions, calibration/confirmation data sets, and model post-audit data sets.'' I have taken this description to refer not only to the evaluation of uncertainty in the field observations themselves, but also to the uncertainty associated the analyses of in situ observations as they interact in the overall modeling process. Thus, I will be concerned here with quantification and reduction of uncertainty both (1) as they may be applied to descriptions of the system that is being modeled and (2) as they may be associated with model ...

1991-01-01

398

Moving train loads identification on a continuous steel truss girder by using dynamic displacement influence line method  

British Library Electronic Table of Contents (United Kingdom)

This paper presents a dynamic displacement influence line method for moving load identification on bridge. The finite element model of Poyang Lake continuous truss bridge-train systems is established and the dispersed modal shapes are acquired by modal analysis. Multi-axle moving train loads are identified with simulated annealing genetic algorithm by minimizing the errors between the measured displacements and the reconstructed displacements from the identified moving loads. In the identification process, the dynamic displacement influence line technique is used to calculate the time history displacement responses of the bridge to avoid solving equations of motion of the bridge repetitively. Several important parameters of the bridge-train system are discussed to investigate their effects...

2011-01-01

399

Historical Indigenous use of aquatic resources in Australia's Murray-Darling Basin, and its implications for river management  

British Library Electronic Table of Contents (United Kingdom)

Summary Indigenous people demonstrably lived along rivers and around lakes and wetlands of Australia's Murray-Darling Basin in pre-European times. Waterways were, and continue to be, of major significance to the society and culture of Aboriginal peoples throughout Australia. Historically, they exploited most of the fauna - from mussels and crayfish, to fish and birds - and either ate, or used for other purposes, many species of aquatic plants. Such practices placed them in the role of environmental modifiers, a role played by all human groups from both past and present. They built sophisticated fish traps, cut gaps in river banks to allow fish to move on to floodplains, and there is evidence that they practised a form of fish culture by creating small impoundments in which small fish could...

2007-01-01

400

Environmental planning for geothermal energy resource exploration, development, and utilization  

Energy Technology Data Exchange (ETDEWEB)

The commercialization of geothermal energy resources consists of a sequence of exploration, development, and utilization activities. Each of these activities are beset by both generic and project specific technical, environmental, and institutional constraints which must be adequately resolved before geothermal operations can be conducted. This report presents a summary of selected environmental activities conducted during the early planning stages of geothermal resource commercialization. Three representative activities are elaborated upon. These include preliminary environmental planning for geothermal energy development in the Medicine Lake Highlands of California; potential alternatives for non-electric use of the geothermal resource at East Mesa in Imperial County, California; and site specific studies of the impacts from using East Mesa geothermal fluids to irrigate selected crops and indigenous climax vegetation.

1982-01-01

401

Environmental impact of a nuclear plant on Mississippi River biota in an ecological recovery zone near Red Wing, Minnesota. Final report  

International Nuclear Information System (INIS)

The biota of the Mississippi River in an ecological recovery zone near Red Wing, MN was studied before and after start-up of a nuclear plant to acquire baseline data and to estimate changes due to thermal addition. Thermal addition produced significant decreases in primary production in a plant region during summer month periods when water temperatures were near 36C. Extensive fisheries studies and sonar tagging/tracking of S. vitreum were performed. Comparison of fisheries results with other riverine, lake, and pond studies indicated a favorable environment for the success of the fish species studied. Qualitative macroinvertebrate surveys were conducted.

402

Effects of Copper, Cadmium, and Zinc on the Hatching Success of Brine Shrimp (Artemia franciscana)  

British Library Electronic Table of Contents (United Kingdom)

Previous studies indicate that the hatching success of brine shrimp (Artemia franciscana) cysts is surprisingly sensitive to ambient metal concentrations. These studies estimated median effective concentrations (EC50s) of 7, 5, and 28??g l?1 for Cd, Cu, and Zn, suggesting that the hatching end point for A. franciscana is the most sensitive tested to date for Cd and Zn in saline environments and comparable in sensitivity with the most sensitive tested to date for Cu. Furthermore, these data suggest that brine shrimp are at significant risk from Cu and Zn in Great Salt Lake (GSL), UT, where ambient concentrations as high as 10 and 14??g l?1, respectively, have been measured. Given that brine shrimp appear to be successfully reproducing in GSL, we hypothesized that these toxicity values were ...

2006-01-01

403

Description of Cretaceous Sedimentary Sequence of the First Member of the Qingshankou Formation Recovered by CCSD-SK-Is Borehole in Songliao Basin: Lithostratigraphy, Sedimentary Facies, and Cyclic Stratigraphy  

British Library Electronic Table of Contents (United Kingdom)

The first member of the Qingshankou Formation recovered by CCSD-SK-Is borehole (China Cretaceous Continental Scientific Drilling-SongkeI-the south borehole) is 81.41 m long, and the recovery of cores is 100%. The age of the member is approximately Turonian. The sequence and process of lithology-lithofacies and cyclic stratigraphy were revealed by a detailed core description. 6 rock types (mudstone, dolomite, marl, limestone, ostracode limestone, and volcanic ash) comprise the sedimentary strata. Deposition occurred in a deep lake, including 6 sedimentary microfacies: mudstone, sandy turbidite, dolomite, marl, limestone, and volcanic ash microfacies. The first member of the Qingshankou Formation represents 81 meter-scale cycles (sixth-order cycle), 25 fifth-order cycles, 6 fourth-order cycl...

2009-01-01

404

Curecanti-Blue Mesa-Salida 115-kV transmission lines access roads rehabilitation, maintenance, and construction project. Environmental Assessment  

Science.gov (United States)

Western Area Power Administration (Western) is a power marketing agency of the US Department of Energy, with jurisdiction in 15 western states. The Salt Lake City Area (SLCA) of Western performs the agency`s mission in parts of Colorado, New Mexico, Texas, Utah, Arizona, Wyoming, and Nevada. As part of its mission, Western owns, operates, and maintains a system of transmission lines for transmitting bulk electrical energy from points of generation to and between delivery points. Part of that system in southwestern Colorado includes the Blue Mesa-Curecanti and Blue Mesa-Salida 115-kV transmission lines. Western proposes to conduct maintenance and improve its access roads for these two transmission lines. This paper discusses the impacts to the existing environment as well as the environmental consequences resulting from the maintenance and construction that is proposed.

1993-07-01

405

Centennial climate variability in the British Isles during the mid-late Holocene  

British Library Electronic Table of Contents (United Kingdom)

Multi-millennial climate changes were relatively minor over the mid-late Holocene in the British Isles, because orbitally forced insolation changes were smaller than those at higher latitudes. Centennial climate variability is thus likely to have exerted a greater influence on the environment and human society of the region. Proxy-climate records from the British Isles covering the last 4500years are assembled and re-evaluated with the aim of identifying centennial climate variability reflected by multi-proxy indicators. The proxies include bog oak populations, peatland surface wetness, flooding episodes from fluvial deposits, speleothem annual band width and oxygen isotopes, chironomids from lake sediments and sand and dune deposition. Most proxies reflect water balance rather than temper...

2010-01-01

406

Causes of denting. Volume 1. Summary report. Final report  

Science.gov (United States)

This summary report outlines the work that was performed to gain a more complete understanding of denting corrosion of steam generators in PWRs. Background laboratory and plant data on denting were compiled, reviewed and correlated to determine how various exposure conditions affect denting. Two high-temperature chemistry analytical models were reviewed and evaluated by experimental simulation of impurity concentration in the heat transfer and isothermal capsule tests. Simulation of impurity concentration for three cooling waters (lake, river, and cooling tower) was evaluated. The effects of species concentration (Cu/sup + +/, Cl/sup -/, O/sub 2/, and H/sup +/), contaminant thresholds (established by isothermal and heat transfer tests), and heat flux as indicated by superheat on denting were examined. A discussion of several pertinent observations and conclusions drawn from these tasks (as they pertain to plant operation) is presented.

1984-05-01

407

Briefing Book, Interagency Geothermal Coordinating Council (IGCC) Meeting of April 28, 1988  

Energy Technology Data Exchange (ETDEWEB)

The IGCC of the U.S. government was created under the intent of Public Law 93-410 (1974) to serve as a forum for the discussion of Federal plans, activities, and policies that are related to or impact on geothermal energy. Eight Federal Departments were represented on the IGCC at the time of this meeting. The main presentations in this report were on: Department of Energy Geothermal R&D Program, the Ormat binary power plant at East Mesa, CA, Potential for direct use of geothermal at Defense bases in U.S. and overseas, Department of Defense Geothermal Program at China Lake, and Status of the U.S. Geothermal Industry. The IGCC briefing books and minutes provide a historical snapshot of what development and impact issues were important at various time. (DJE 2005)

1988-04-28

408

Bottom-up carbon subsidies and top-down predation pressure interact to affect aquatic food web structure  

British Library Electronic Table of Contents (United Kingdom)

Human impacts such as eutrophication, overexploitation and climate change currently threaten future global food and drinking water supplies. Consequently, it is important that we understand how anthropogenic resource (bottom-up) and consumer (top-down) manipulations affect aquatic food web structure and production. Future climate changes are predicted to increase the inputs of terrestrial dissolved organic carbon to lakes. These carbon subsidies can either increase or decrease total basal production in aquatic food webs, depending on bacterial competition with phytoplankton for nutrients. This study examines the effects of carbon subsidies (bottom-up) on a pelagic community exposed to different levels of top-down predation. We conducted a large scale mesocosm experiment in an oligotrophic ...

2011-01-01

409

Biomass power for rural development. Quarterly report, July 3--December 4, 1997  

Energy Technology Data Exchange (ETDEWEB)

This paper describes progress in several projects related to biomass power. These include switchgrass conversion development; switchgrass gasification development; production activities including soil studies, carbon studies, switchgrass production economics, watershed impacts, and prairie lands bio-products; information and education; and geographical information system. Attachments describe switchgrass co-firing test; switchgrass production in Iowa; cooperative agreements with ISU; Rathbun Lake watershed project; newspaper articles and information publications; Secretary of Agriculture Glickman`s visit; integration of technical aspects of switchgrass production in Iowa; and evaluation of an integrated biomass gasification/fuel cell power plant.

1998-03-01

410

Tumor burden assessed by maxSUV and metabolic size on FDG-PET predicts prognosis of small cell lung cancer  

Energy Technology Data Exchange (ETDEWEB)

There are few studies that focused on the prognostic value of FDG-PET on small cell lung cancer (SCLC). Not only FDG uptake (maxSUV), but also metabolic size (greatest dimension of PET positive mass) may determine the prognosis of SCLC. Here, we investigated the prognostic significance of maxSUV, and the metabolic size in SCLC patients. Biopsy-proven SCLC patients (n=21; age, means.d.=67.39y; male: female=19: 3) who had underwent FDG-PET within 4 weeks of chemotherapy initiation were enrolled. There were 7 extensive disease (ED) and 14 limited disease (LD) patients. The maxSUV and the metabolic size were measured, and then, size-incorporated maxSUV (SIMaxSUV = maxSUV x metabolic size) were calculated at individual SCLC masses. SIMaxSUV of main lesion (main-SIMaxSUV), and the summed value of SIMaxSUV of all PET positive masses (summed-SIMaxSUV) were obtained. In addition, age, stage, and %expression of ...

2007-07-01

411

The relationship between periodontitis and metabolic syndrome among a Korean nationally representative sample of adults  

British Library Electronic Table of Contents (United Kingdom)

Abstract Aims: The aim of this study was to examine whether metabolic syndrome (MS) is associated with periodontitis in a representative sample of Korean adults, who were involved in the Fourth Korea National Health and Nutrition Examination Survey (KNHANES). Materials and Methods: A total of 7178 subjects over the age of 19 years who participated in KNHANES were examined. MS was defined as the definition proposed by the National Cholesterol Education Program Adult Treatment Panel III and the abdominal obesity cut-off line based on Korean Society for the Study of Obesity. The periodontal status was assessed by the Community Periodontal Index. Multivariate logistic regression analysis was carried out adjusting for the sociodemographics, oral health behaviours and status, and health behaviou...

2011-01-01

412

The disruption of l-carnitine metabolism by aluminum toxicity and oxidative stress promotes dyslipidemia in human astrocytic and hepatic cells  

British Library Electronic Table of Contents (United Kingdom)

l-Carnitine is a critical metabolite indispensable for the metabolism of lipids as it facilitates fatty acid transport into the mitochondrion where b-oxidation occurs. Human astrocytes (CCF-STTG1 cells) and hepatocytes (HepG2 cells) exposed to aluminum (Al) and hydrogen peroxide (H2O2), were characterized with lower levels of l-carnitine, diminished b-oxidation, and increased lipid accumulation compared to the controls. g-Butyrobetainealdehyde dehydrogenase (BADH) and butyrobetaine dioxygenase (BBDOX), two key enzymes mediating the biogenesis of l-carnitine, were sharply reduced during Al and H2O2 challenge. Exposure of the Al and H2O2-treated cells to a-ketoglutarate (KG), led to the recovery of l-carnitine production with the concomitant reduction in ROS levels. It appears that the chann...

2011-01-01

413

Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism  

British Library Electronic Table of Contents (United Kingdom)

Translating experimental findings into clinically effective therapies is one of the major bottlenecks of modern medicine. As this has been particularly true for cerebrovascular research, attention has turned to the quality and validity of experimental cerebrovascular studies. We set out to assess the study design, statistical analyses, and reporting of cerebrovascular research. We assessed all original articles published in the Journal of Cerebral Blood Flow and Metabolism during the year 2008 against a checklist designed to capture the key attributes relating to study design, statistical analyses, and reporting. A total of 156 original publications were included (animal, in vitro, human). Few studies reported a primary research hypothesis, statement of purpose, or measures to safeguard in...

2011-01-01

414

Studies on adjuvant parenteral nutrition during chemotherapeutic and radiotherapeutic measures in haematological disorders  

International Nuclear Information System (INIS)

In patients subjected to bone marrow transplantation the aggressive measures necessarily preceding this treatment lead to drastic metabolic changes which, in turn, are a cause of marked disturbances of homeostasis. The general preparatory measures in the form of cytoreduction by cytostatic drugs are broadened for leukaemic patients to include wholebody irradiation. During the study described here investigations were carried out into the resulting strain on the metabolism. One of the most essential changes observed in those patients was a nitrogen loss of up to approx. 20 g/day that occurred during the immunosuppressive phase. This was accompanied by markedly pronounced variations in fluid elimination, which partly were of an iatrogenic nature. An immediate and sufficient substitution of amino acids in connection with complete parenteral nutrition rapidly acted to compensate for the nitrogen losses, even though these could not be totally ...

415

Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility: a 24-week pilot study  

British Library Electronic Table of Contents (United Kingdom)

BACKGROUNDLifestyle modifications are successfully employed to treat obese and overweight women with polycystic ovary syndrome (PCOS). The aims of the current pilot study were (i) to compare the efficacy on reproductive functions of a structured exercise training (SET) programme with a diet programme in obese PCOS patients and (ii) to study their clinical, hormonal and metabolic effects to elucidate potentially different mechanisms of action.METHODSForty obese PCOS patients with anovulatory infertility underwent a SET programme (SET group, n = 20) and a hypocaloric hyperproteic diet (diet group, n = 20). Clinical, hormonal and metabolic data were assessed at baseline, and at 12- and 24-week follow-ups. Primary endpoint was cumulative pregnancy rate.RESULTSThe two groups had similar demogra...

2008-01-01

416

Quantitative Computed Tomography (QCT) of vertebral spongiosa. Evaluation of a possible method for managment of postmenopausal osteoporosis (PMO)  

International Nuclear Information System (INIS)

A Quantitative Computed Tomography (QCT) method, simplifying the well-known technique proposed by Genant (1982) and applied to a standard third generation whole body CT scanner is described. This technique was applied in the measurement of the trabecular bone which has high sensitivity for metabolic changes. The BMC (Bone Mineral Content) measured in different groups of subjects (healthy postmenopausal patients versus women with postmenopausal osteoporosis) showed a highly significant difference (p<0.001). The precision of repositioning (coefficient of variation 1.8% to 2.3%, obtained in healty male patients) and the good, linear relationship computed from the phantom values, minimize measurement errors. Since this method is quickly applied and involves low-dose radiation-exposure, it could be introduced in the clinical study of metabolic bone diseases.

1987-01-01

417

Peroxisomal hydroxypyruvate reductase is not essential for photorespiration in Arabidopsis but its absence causes an increase in the stoichiometry of photorespiratory CO2 release  

British Library Electronic Table of Contents (United Kingdom)

Recycling of carbon by the photorespiratory pathway involves enzymatic steps in the chloroplast, mitochondria, and peroxisomes. Most of these reactions are essential for plants growing under ambient CO2 concentrations. However, some disruptions of photorespiratory metabolism cause subtle phenotypes in plants grown in air. For example, Arabidopsis thaliana lacking both of the peroxisomal malate dehydrogenase genes (pmdh1pmdh2) or hydroxypyruvate reductase (hpr1) are viable in air and have rates of photosynthesis only slightly lower than wild-type plants. To investigate how disruption of the peroxisomal reduction of hydroxypyruvate to glycerate influences photorespiratory carbon metabolism we analyzed leaf gas exchange in A. thaliana plants lacking peroxisomal HPR1 expression. In addition, b...

2011-01-01

418

Metabolite profiling of sucrose effect on the metabolism of Melissa officinalis by gas chromatography-mass spectrometry  

British Library Electronic Table of Contents (United Kingdom)

The effect of sugar on plant metabolism, which is known to be similar to hormone-like signaling, was metabolomically studied using Melissa officinalis (lemon balm). The metabolite profiles of M. officinalis treated with sucrose were analyzed by gas chromatography-mass spectrometry (GC-MS) and principal component analysis (PCA). A total of 64 metabolites from various chemical classes including alcohols, amines, amino acids, fatty acids, inorganic acids, organic acids, phosphates, and sugars were identified by GC-MS. Three groups treated with different sucrose concentrations were clearly separated by PCA of their metabolite profiles, indicating changes in the levels of many metabolites depending on the sucrose concentration. Metabolite profiling revealed that treatment with a higher sucrose ...

2011-01-01

419

Labelling of amphetamines with /sup 123/I  

International Nuclear Information System (INIS)

Within the past decade two important groups of radiopharmaceuticals labelled with /sup 123/I were introduced into the clinical application opening new areas of metabolic studies in nuclear medicine: radioiodinated fatty acids were developed for metabolic studies of the myocardium and radioiodinated amphetamine derivatives were prepared for studying brain diseases by means of SPECT. It must be emphasized that the radiochemical problems with both groups of compounds are practically the same since both are radioiodinated by a nucleophilic substitution mechanism using /sup 123/I directly in its anionic form. The clinical application of brain imaging agents, particularly the one of p-/sup 123/I-iodo-N-isopropylamphetamine, is important and will presumably increase as soon as the details of the individual biochemical steps, which are involved in brain uptake mechanisms, are evaluated. It is felt that the potential of the clinical IMP application is ...

420

Impaired mitochondrial energy metabolism and kinetic properties of cytochrome oxidase following acute aluminium phosphide exposure in rat liver  

British Library Electronic Table of Contents (United Kingdom)

The present study was designed with an aim to analyze the effect of acute aluminium phosphide (ALP) exposure (10mg/kg b.wt, intragastrically) on the kinetic characteristics of cytochrome oxidase and energy metabolism in male Wistar rat liver mitochondria. Liver mitochondrial preparations from ALP-treated rats exhibited significant decrease (66%) in the activity of cytochrome oxidase suggesting that there was a decrease in the catalytic efficiency of the active oxidase molecules on ALP treatment. The decreased activity of cytochrome oxidase with altered NADH and succinic dehydrogenase activities might have contributed towards a significant decline in state 3 and state 4 respiration as observed. These alterations in the electron transport chain complexes in turn adversely affected the ATP sy...

2010-01-01

421

Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster  

British Library Electronic Table of Contents (United Kingdom)

Background In chordates, retinoid metabolism is an important target of short-chain dehydrogenases/reductases (SDRs). It is not known whether SDRs play a role in retinoid metabolism of protostomes, such as Drosophila melanogaster. Methods Drosophila genome was searched for genes encoding proteins with ?50% identity to human retinol dehydrogenase 12 (RDH12). The corresponding proteins were expressed in Sf9 cells and biochemically characterized. Their phylogenetic relationships were analyzed using PHYLIP software. Results A total of six Drosophila SDR genes were identified. Five of these genes are clustered on chromosome 2 and one is located on chromosome X. The deduced proteins are 300 to 406 amino acids long and are associated with microsomal membranes. They recognize all-trans-retinaldehyd...

2009-01-01

422

Human climatic comfort within enclosing walls with varying strengths of infrared radiation reflection  

Energy Technology Data Exchange (ETDEWEB)

An experiment lasting a number of hours was carried out with 6 men under standardised climate chamber conditions to find out to what extent wallpaper that reflects about 65-75% in the infra-red range by comparison with normal wallpaper that reflect only 3-5% of heat, has measurable positive effects on the thermoregulation of the human body and the human sensation of temperature. The measurements of skin temperature and heat flow intensity in the deeper areas of the body and the periphery, and metabolic heat conversion measurements (indirect calorimetry) confirm that infra-red reflection of the heat irradiated from the body lead to a measurable heat recovery on the body surface with a reduction of metabolic conversion. It was proved that it is possible to reduce the average room temperature by up to 4 K whilst maintaining the same degree of thermal comfort, which corresponds to a 20% saving in heating energy. (orig./BWI).

1985-06-01

423

Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis  

Science.gov (United States)

Hydrogen cyanide (HCN) production by Pseudomonas aeruginosa in a synthetic medium is stimulated by the presence of glycine. Methionine enhances this stimulation but will not substitute for glycine as a stimulator of cyanogenesis. Threonine and phenylalanine are effective substitutes for glycine in the stimulation of HCN production. Glycine, threonine, and serine are good radioisotope precursors of HCN, but methionine and phenylalanine are not. Cell extracts of P. aeruginosa convert (/sup 14/C)threonine to (/sup 14/C)glycine. H14CN is produced with low dilution of label from either (1-/sup 14/C)glycine or (2-/sup 14/C)glycine, indicating a randomization of label either in the primary or secondary metabolism of glycine. When whole cells were fed (1,2-/sup 14/C)glycine, cyanide and bicarbonate were the only radioactive extracellular products observed.

1977-05-01

424

Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17  

British Library Electronic Table of Contents (United Kingdom)

Obesity is associated with increased susceptibility to dyslipidemia, insulin resistance, and hypertension, a combination of traits that comprise the traditional definition of the metabolic syndrome. Recent evidence suggests that obesity is also associated with the development of nonalcoholic fatty liver disease (NAFLD). Despite the high prevalence of obesity and its related conditions, their etiologies and pathophysiology remains unknown. Both genetic and environmental factors contribute to the development of obesity and NAFLD. Previous genetic analysis of high-fat, diet-induced obesity in C57BL/6J (B6) and A/J male mice using a panel of B6-ChrA/J/NaJ chromosome substitution strains (CSSs) demonstrated that 17 CSSs conferred resistance to high-fat, diet-induced obesity. One of these CSS st...

2009-01-01

425

Effects of Valproic Acid on Organic Acid Metabolism in Children: A Metabolic Profiling Study  

British Library Electronic Table of Contents (United Kingdom)

Young children are at increased risk for valproic acid (VPA) hepatotoxicity. Urinary organic acid profiles, as a surrogate of mitochondrial function, were obtained in children 1.9 to 17.3 years of age (n = 52) who were undergoing treatment with VPA for seizure disorders. Age-matched patients receiving treatment with carbamazepine (CBZ; n = 50) and healthy children not undergoing treatment (n = 22) served as controls. Age-related changes in organic acid profiles were observed in all three groups. Although the untreated and CBZ control groups were indistinguishable from each other with respect to the principal-component analysis (PCA) score plots of the subjects, a distinct boundary was apparent between the VPA and each of the control groups. Interindividual variability was observed in the V...

2011-01-01

426

Comparative Evaluation of Different Cell Lysis and Extraction Methods for Studying Benzo(a)pyrene Metabolism in HT-29 Colon Cancer Cell Cultures  

British Library Electronic Table of Contents (United Kingdom)

Abstract Lysis and extraction of cells are essential sample processing steps for investigations pertaining to metabolism of xenobiotics in cell culture studies. Of particular importance to these procedures are maintaining high lysis efficiency and analyte integrity as they influence the qualitative and quantitative distribution of drug and toxicant metabolites in the intra- and extracellular milieus. In this study we have compared the efficiency of different procedures viz. homogenization, sonication, bead beating, and molecular grinding resin treatment for disruption of HT-29 colon cells exposed to benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH) compound and a suspected colon carcinogen. Also, we have evaluated the efficiency of various procedures for extracting BaP parent c...

2011-01-01

427

Chromatographic evaluation of microbial activity in biological activated carbon bed; Kuromatoho ni yoru seibutsu kasseitanso ni okeru biseibutsu kassei no hyoka  

Energy Technology Data Exchange (ETDEWEB)

The moment analysis of pulse responses was applied to a biological activated carbon (BAC) bed to evaluate the microbial activity. Glucose and activated carbon fiber (ACF) were employed in experiments as a model tracer and an activated carbon respectively. No significant difference in biodegradation rates of glucose by microorganisms attached on different solid supports such as activated carbon inactivated carbon and glass fibers was observed. However, higher microbial activity was obtained from microorganisms supported on the ACF in terms of the apparent degradation of total organic including metabolic byproducts by microorganisms, since part of the metabolic byproducts was irreversibly deposited onto the ACF. 11 refs., 6 figs.

1996-07-10

428

Changes in Energy Metabolism and Antioxidant Defense Systems During Seed Germination of the Weed Species Ipomoea triloba L. and the Responses to Allelochemicals  

British Library Electronic Table of Contents (United Kingdom)

The relationships between changes in energy metabolism and the antioxidant defense system in the weed species Ipomoea triloba L. during seed germination and early seedling growth were investigated. The effects of some common allelochemicals on these parameters also were studied. Respiratory activity and the activities of alcohol dehydrogenase, superoxide dismutase, catalase, guaicol peroxidase, ascorbate peroxidase, glutathione reductase, and lipoxygenase were measured. Mitochondrial oxidative phosphorylation resumed shortly after the seed imbibition period, as indicated by considerable KCN-sensitive respiratory activity in embryos of I. triloba. The occurrence of superoxide dismutase, catalase, guaicol peroxidase, and lipoxygenase activities in the embryos, along with significant KCN-inse...

2011-01-01

429

Cell-mediated mutagenesis and cell transformation of mammalian cells by chemical carcinogens. [Rats, hamsters  

Science.gov (United States)

We have developed a cell-mediated mutagenesis assay in which cells with the appropriate markers for mutagenesis are co-cultivated with either lethally irradiated rodent embryonic cells that can metabolize carcinogenic hydrocarbons or with primary rat liver cells that can metabolize chemicals carcinogenic to the liver. During co-cultivation, the reactive metabolites of the procarcinogen appear to be transmitted to the mutable cells and induce mutations in them. Assays of this type make it possible to demonstrate a relationship between carcinogenic potency of the chemicals and their ability to induce mutations in mammalian cells. In addition, by simultaneously comparing the frequencies of transformation and mutation induced in normal diploid hamster cells by benzo(a)pyrene (BP) and one of its metabolites, it is possible to estimate the genetic target size for cell transformation in vitro.

1977-01-01

430

Brain glucose sensing and neural regulation of insulin and glucagon secretion  

British Library Electronic Table of Contents (United Kingdom)

Glucose homeostasis requires the tight regulation of glucose utilization by liver, muscle and white or brown fat, and glucose production and release in the blood by liver. The major goal of maintaining glycemia at -5 mM is to ensure a sufficient flux of glucose to the brain, which depends mostly on this nutrient as a source of metabolic energy. This homeostatic process is controlled by hormones, mainly glucagon and insulin, and by autonomic nervous activities that control the metabolic state of liver, muscle and fat tissue but also the secretory activity of the endocrine pancreas. Activation or inhibition of the sympathetic or parasympathetic branches of the autonomic nervous systems are controlled by glucose-excited or glucose-inhibited neurons located at different anatomical sites, mainl...

2011-01-01

431

A comparison of hepatic in vitro metabolism of T-2 toxin in rats, pigs, chickens, and carp  

British Library Electronic Table of Contents (United Kingdom)

T-2 toxin, a highly toxic member of the type-A trichothecenes, is produced by various Fusarium moulds that can potentially affect human health. It is strongly cytotoxic for human hematopoietic progenitors. Alimentary toxic aleukia (ATA), a disease typically associated with human, is primarily induced by T-2 toxin. A comparison of the metabolism of T-2 toxin incubated with hepatocytes of rats, piglets, chickens, and the hepatic subcellular fractions (microsomes and cytosol) of piglets, chickens, rats, and carp (common carp and grass carp) was carried out. The activities of the recombinant pig CYP3A29 on the transformation of T-2 and HT-2 toxins were preliminary studied. Metabolites were identified by novel LC/MS-IT-TOF. Qualitative similarities and differences across the species were observ...

2011-01-01

432

A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein  

British Library Electronic Table of Contents (United Kingdom)

Allyl acetate (AAC), allyl alcohol (AAL), and acrolein (ACR) are used in the manufacture of detergents, plastics, pharmaceuticals, and chemicals and as agricultural agents. A metabolic relationship exists between these chemicals in which allyl acetate is metabolized to allyl alcohol and subsequently to the highly reactive, a,b-unsaturated aldehyde, acrolein. Due to the weaker reactivity of the protoxicants, allyl acetate and allyl alcohol, relative to acrolien we hypothesized the protoxicants would attain greater systemic exposure and therefore deliver higher doses of acrolein to the internal organs. By extension, the higher systemic exposure to acrolein we hypothesized should lead to more internal organ toxicity in the allyl acetate and allyl alcohol treated animals relative to those trea...

2008-01-01

433

Woodwaste incineration and air quality in Williams Lake  

Energy Technology Data Exchange (ETDEWEB)

Large volumes of woodwaste disposal by incineration in a number of wigwam burners are contributing to pollution problems in Williams Lake, British Columbia. In 1985, the latest year for which data are available, total woodwaste production was about 800 million bd ft equivalent; only about 14% of this was used for energy recovery. In addition, about 66,000 m/sup 3/ of waste was sent to landfills after open burning. The characteristics of the local woodwaste are summarized, and available conversion technologies and the potential application of their products are reviewed. These include direct combustion, pyrolysis, gasification, liquefaction, and densification, for use in power generation, cogeneration, and the manufacture of saleable products. Environmental and legal aspects of woodwaste utilization are also outlined. Finally, options for reducing pollution from existing burners are reviewed. One option is the upgrading of existing burners; however, it is noted that ...

1988-01-01

434

Ultra fine grinding of low-rank coal. Progress report, April-June 1986  

Energy Technology Data Exchange (ETDEWEB)

The lignite used for Phase I of the project was a Texas lignite from the Martin Lake mine obtained from the stockpile for the Martin Lake Power Plant of the Texas Utilities Generating Company. The power requirements for the fluid-energy mill were determined from the measured steam (or air) temperatures, pressures and pressure drops and the lignite flow rate. The instrument locations for the tests are shown on Figure 1. All of the instruments were connected to a microcomputer via an analog input interface board. Data were recorded on disks periodically throughout the tests. Appropriate calibration procedures were followed to assure that reliable data were being obtained. The combined grinding/drying tests were conducted in Vicksbuth, MS at Ergon, Inc.'s fluid-energy-mill facility. both steam and air were used as grinding fluids. With steam, tests were used as grinding fluids. With steam, tests were run with the following temperatures ...

1986-07-01

435

Structural evolution of Lake Superior II: Eastern basin  

Energy Technology Data Exchange (ETDEWEB)

The authors have interpreted 1,400 km of industry and government multichannel seismic reflection data from eastern Lake Superior. Seismic sequences have been identified by using reflection character and reflector terminations and truncations. This framework, coupled with outcrop information, has allowed them to assign lithologic units to some of these reflectors and reconstruct the timing and geometry of structures within the basin. The authors have mapped the Base Jacobsville-Bayfield Group/Top oronto Group, Base oronto Group/Top Keweenawan volcanics, and Basement as well as several reflectors internal to these groups. Integration of gravity and magnetic data with the seismic grid permits regional mapping of faults and folds between seismic lines. In the eastern part of the basin, high-angle basement-involved reverse faults, such as the southeastern combination of the Keweenaw fault, trend NNW-SSE, while broad folds trend E-W. The Keweenaw fault is a complex ...

1992-01-01

436

Microclimatic models. Estimation of components of the energy balance over land surfaces  

Energy Technology Data Exchange (ETDEWEB)

Climates at regional scale are strongly dependent on the interaction between atmosphere and its lower boundary, the oceans and the land surface mosaic. Land surfaces influence climate through their albedo, and the aerodynamic roughness, the processes of the biosphere and many soil hydrological properties; all these factors vary considerably geographically. Land surfaces receive a certain portion of the solar irradiance depending on the cloudiness, atmospheric transparency and surface albedo. Short-wave solar irradiance is the source of the heat energy exchange at the earth`s surface and also regulates many biological processes, e.g. photosynthesis. Methods for estimating solar irradiance, atmospheric transparency and surface albedo were reviewed during the course of this project. The solar energy at earth`s surface is consumed for heating the soil and the lower atmosphere. Where moisture is available, evaporation is one of the key components of the surface energy balance, because the ...

1996-12-31

437

Metallurgical Laboratory Hazardous Waste Management Facility groundwater monitoring report. Third quarter, 1994  

Energy Technology Data Exchange (ETDEWEB)

During third quarter 1994, samples from AMB groundwater monitoring wells at the Metallurgical Laboratory Hazardous Waste Management Facility (Met Lab HWMF) were analyzed for selected heavy metals, indicator parameters, radionuclides, volatile organic compounds, and other constituents. Eight parameters exceeded standards during the quarter. As in previous quarters, tetrachloroethylene and trichloroethylene exceeded final Primary Drinking Water Standards (PDWS). Bis(2-ethylhexyl) phthalate exceeded final PDWS in one well. Aluminum, iron, manganese, tin, and total organic halogens exceeded the Savannah River Site (SRS) Flag 2 criteria. Groundwater flow direction and rate in the M-Area Aquifer Zone were similar to previous quarters. Conditions affecting determination of groundwater flow directions and rates in the Upper Lost Lake Aquifer Zone, Lower Lost Lake Aquifer Zone, and the Middle Sand Aquifer Zone of the Crouch Branch Confining Unit were ...

1994-12-01

438

Depositional setting of the Upper Jurassic Hith Anhydrite of the Arabian Gulf: An analog to holocene evaporites of the United Arab Emirates and Lake MacLeod of Western Australia  

Energy Technology Data Exchange (ETDEWEB)

The Upper Jurassic Hith Anhydrite is a major hydrocarbon seal in the Arabian Gulf region. Outcrops, core samples from the subsurface, and the literature indicate that the Hith Formation is composed mainly of anhydrite. In most locations where a section of the Hith Formation has been measured, this unit contains less than 20% carbonate much of which is in the form of thin laminations. This lack of carbonate, locally thick layers of salt, and the predominance of anhydrite favor a playa for the setting in which this sediment was accumulated. In fact, much of the Hith has the sedimentary characteristics of the Holocene Lake MacLeod playa of Western Australia, which is dominated by layers of gypsum and halite (what little carbonate that occurs is found in layers at the base of the section). Locally the Hith appears to have accumulated in a sabkha setting, particularly toward central Abu Dhabi where it pinches out into shallow-water, and peritidal carbonate. This sabkha ...

1994-07-01

439

Coprocessing of coal and oil sand bitumen; Sekitan to oil bitumen tono coprocessing  

Energy Technology Data Exchange (ETDEWEB)

Co-processing of Battle River coal and Cold Lake oil sand bitumen from Canada was carried out in the presence of Ni-Mo, Co-Mo and red-mud/sulfur catalysts under reaction conditions of 400-450{degree}C, 10-120 min and 22-23 MPa of reaction hydrogen pressure by using a 500 ml shaking-type autoclave. The conversion of Battle River coal during the reprocessing was 97.1 wt% (daf) at 450{degree}C for 121 min with Ni-Mo catalyst, higher than 95.7 wt% (daf) at 450{degree}C for 120 min with red-mud/sulfur catalyst and anthracite oil. Cold lake oil sand bitumen was excellent solvent to liquefy Battle River coal comparing with anthracite on. In the presence of Ni-Mo catalyst during the coprocessing, the hydrogen consumption was nearly the same as that with red-mud/sulfur catalyst. Ni-Mo catalyst gave higher conversion of Battle River coal in the initial stage of the reaction than red-mud/sulfur catalyst. Ni-Mo catalyst also showed good activities for ...

1995-12-10

440

Coal compilation project - entrance NTS 83F/5  

Energy Technology Data Exchange (ETDEWEB)

The main objective of the pilot Coal Compilation Project is to provide coal resource maps to stimulate and support industry exploration programs, and assist government in matters of resource management. An essential feature of the program is the use of cost effective Geoscience Information System (GSIS) technology that allows the database and various thematic maps to be analyzed, updated, and displayed with complete flexibility at any scale. This report describes the main features (geology, exploration history, coal occurrences, coal quality etc.) of the study area, map sheet NTS 83F/5 (Entrance), and includes a copy of the 1:50,000 scale map produced. The study area is located in west-central Alberta and contains coal measures deposited within thick successions of sandstones, siltstones, shales and conglomerates. These coal-bearing sequences are part of the Lower Cretaceous Luscar Group, Upper Cretaceous Brazeau Formation and Paleocene Coalspur Formation. The present mapsheet contains ...

1990-01-01

441

Coal compilation project - Pierre Greys Lakes NTS 83E/15  

Energy Technology Data Exchange (ETDEWEB)

The main purpose of the pilot Coal Compilation Project is to provide coal resource maps to stimulate and support industry exploration programs, and assist government in matters of resource management. An essential feature of the program is the use of cost effective Geoscience Information System (GSIS) technology that allows the database and various thematic maps to be analyzed, updated, and displayed with complete flexibility at any scale. This report describes the main features (geology, resource management, coal occurrences, etc.) of the study area, mapsheet NTS 83E/15 (Pierre Greys Lakes), and includes a copy of the 1:50,000 scale map produced. The study area is located in west-central Alberta and contains coal measures deposited amid thick successions of sandstones, siltstones, shales and conglomerates. These coal-bearing sequences are part of the Lower Cretaceous Luscar Group, Upper Cretaceous Brazeau Formation and Paleocene Coalspur Formations. Within the ...

1990-01-01

442

Characterization of crystalline rocks in the Lake Superior region, USA: implications for nuclear waste isolation. [Wisconsin, Upper Peninsula of Michigan and Minnesota  

Energy Technology Data Exchange (ETDEWEB)

The Lake Superior region (Wisconsin, the Upper Peninsula of Michigan, and Minnesota) contains 41 Precambrian crystalline rock complexes comprising 64 individual but related rock bodies with known surface exposures. Each complex has a map area greater than 78 km/sup 2/. About 54% of the rock complexes have areas of up to 500 km/sup 2/, 15% fall between 500 km/sup 2/ and 1000 km/sup 2/, 19% lie between 1000 km/sup 2/ and 2500 km/sup 2/, and 12% are over 2500 km/sup 2/. Crystalline rocks of the region vary widely in composition, but they are predominantly granitic. Repeated thermo-tectonic events have produced early Archean gneisses, migmatites, and amphibolites with highly tectonized fabrics that impart a heterogeneous and anisotropic character to the rocks. Late Archean rocks are usually but not invariably gneissose and migmatitic. Proterozoic rocks of the region include synorogenic (foliated) granitic rocks, anorogenic (non-foliated) granites, and the layered ...

1984-01-01

443

Variations in Kinetic Properties of Ribulose-1,5-bisphosphate Carboxylases among Plants  

UK PubMed Central (United Kingdom)

Studies of ribulose-1,5-bisphosphate (RuBP) carboxylase from taxonomically diverse plants show that the enzyme from C3 and crassulacean acid metabolism pathway species exhibits lower Km(CO2)...Full Text Available

1981-06-01

444

The metabolism of L-tryptophan by isolated rat liver cells. Effect of albumin binding and amino acid competition on oxidatin of tryptophan by tryptophan 2,3-dioxygenase.  

UK PubMed Central (United Kingdom)

1. Novel methods, using L-[ring-2-14C]tryptophan, are described for the measurement of tryptophan 2,3-dioxygenase activity and tryptophan accumulation in isolated rat liver cells. 2. The effects of...Full Text Available

1980-03-15

445

The Protein Kinase SnRK2.6 Mediates the Regulation of Sucrose Metabolism and Plant Growth in Arabidopsis[W][OA]  

UK PubMed Central (United Kingdom)

In higher plants, three subfamilies of sucrose nonfermenting-1 (Snf1)-related protein kinases have evolved. While the Snf1-related protein kinase 1 (SnRK1) subfamily has been shown to share pivotal...Full Text Available

2010-05-01

446

Systemic responses to inhaled ozone in mice: cachexia and down-regulation of liver xenobiotic metabolizing genes  

International Nuclear Information System (INIS)

Rats or mice acutely exposed to high concentrations of ozone show an immediate and significant weight loss, even when allowed free access to food and water. The mechanisms underlying this systemic response to ozone have not been previously elucidated. We have applied the technique of global gene expression analysis to the livers of C57BL mice acutely exposed to ozone. Mice lost up to 14% of their original body weight, with a 42% decrease in total food consumption. We previously had found significant up-regulation of genes encoding proliferative enzymes, proteins related to acute phase reactions and cytoskeletal functions, and other biomarkers of a cachexia-like inflammatory state in lungs of mice exposed to ozone. These results are consistent with a general up-regulation of different gene families responsive to NF-#kappa#B in the lungs of the exposed mice. In the present study, we observed significant down-regulation of different families of mRNAs in the livers of the exposed mice, ...

2005-10-15

447

Synergistic Activation of Glucose-6-Phosphate Dehydrogenase and NAD(P)H oxidase by Src kinase Elevates Superoxide in Type 2 Diabetic, Zucker fa/fa, Rat Liver  

UK PubMed Central (United Kingdom)

Glucose metabolism through glycolysis and hexosamine pathway has been shown to be altered in type 2 diabetes. However, its fate through the pentose phosphate pathway (PPP) is currently unclear....Full Text Available

2009-08-01

448

Stable isotopes in plant nutrition, soil fertility and environmental studies  

International Nuclear Information System (INIS)

The individual contributions in these proceedings are indexed separately. Main topics covered include the measurement of biological nitrogen fixation, studies of soil organic matter, investigations of nutrient uptake and use by plants, studies of plant metabolism and new methodologies in the analysis of stable isotopes. Refs, figs and tabs.

1990-10-01

449

Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae  

UK PubMed Central (United Kingdom)

BackgroundWhen eukaryotic cells are deprived of amino acids, uncharged tRNAs accumulate and activate the conserved GCN2 protein kinase. Activated Gcn2p up-regulates the general amino...Full Text Available

450

Quantitative 31P NMR Spectroscopy and 1H MRI Measurements of Bone Mineral and Matrix Density Differentiate Metabolic Bone Diseases in Rat Models  

UK PubMed Central (United Kingdom)

In this study, bone mineral density (BMD) of normal (CON), ovariectomized (OVX) and partially nephrectomized (NFR) rats was measured by 31P NMR spectroscopy; bone matrix density was...Full Text Available

2010-06-01

451

Purification by Immunoadsorption and Immunochemical Properties of NADP-Dependent Malic Enzymes from Leaves of C3, C4, and Crassulacean Acid Metabolism Plants  

UK PubMed Central (United Kingdom)

NADP:malic enzyme from corn (Zea mays L.) leaves was purified by conventional techniques to apparent homogeneity as judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis....Full Text Available

1990-03-01

452

Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk  

DEFF Research Database (Denmark)

Colorectal cancer is the third most common malignant tumor and the fourth-leading cause of cancer death worldwide. The crucial role of fatty acids for a number of important biological processes suggests a more in depth analysis of inter-individual differences in fatty acid metabolizing genes as contributing factor to colon carcinogenesis. We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. 392 single nucleotide polymorphisms were selected using pairwise tagging with an r(2) cutoff of 0.8 and a minor allele frequency of >5%. Conditional logistic regression models were used to estimate odds ratios and corresponding 95% confidence intervals. Haplotype analysis was performed using a generalized linear model framework. On the genotype level, HPGD, PLA2G6, and ...

2010-01-01

453

Plant Sulphur Nutrition  

Environmental Research Database

DescriptionThe recent sequencing of the complete genomes of several streptomycete species revealed the presence of a large number of cryptic' secondary metabolic gene clusters, and led to the realisation that these organisms have the ability to produce many more natural products than had previously been recognised. One of the aims of our work is to identify the physiological signals and regulatory mechanisms responsible for the activation of these 'cryptic' pathways, thus unleashing the full biosynthetic p [continued...

2010-01-31

454

Phase I Report: Technetium Radiotracers for the Dopamine Transporter. [September 1998 - March 1999  

Energy Technology Data Exchange (ETDEWEB)

This project (a) demonstrated specific dopamine transporter (DAT) uptake in vivo and metabolic stability of a radiolabelled cycloplentadieny rhenium compound in rats and baboons, (b) showed that cyclopentadieny tricarbonyl rhenium and technetium compounds conjugated tropanel could be made by metal transfer with ferrocenes; and (c) explored new methods of synthesizing these compounds under mild conditions.

1999-03-17

455

Open top chamber experiment ``Edelmannshof``: carbohydrate and energy metabolism in needles and trunks from Norway spruce fumigated with unfiltered or charcoal-filtered air in comparison with untreated trees  

Energy Technology Data Exchange (ETDEWEB)

As part of a five-year-lasting open-top-chamber experiment at the `Edelmannshof` site (Welzheimer Wald) we analyzed Norway spruce trees (Picea abies (L.) Karst.) with regard to carbohydrate and energy (ATP/ADP ratio) metabolism. End products, intermediates, and a regulator of carbon allocation (starch, sucrose, hexoses, fructose-2,6-bisphosphate) as well as enzyme activities involved in sucrose metabolism (sucrose-P synthase, sucrose synthase, acid invertase) were determined in needle and trunk samples of the different treatments (charcoal-filtered, unfiltered, ambient air). Changes of these parameters were documented annually and with regard to needle development (up to 2 years after bud break), and diurnally during an ozone period in midsummer. Samples from trees grown in an unfiltered atmosphere showed relatively high sucrose and hexose contents of the needles. The capacities of sucrose-P synthase (increased; sucrose synthesis) and acid ...

1997-12-01

456

One-carbon metabolism in methanogenic bacteria: analysis of short-term fixation products of 14CO2 and 14CH3OH incorporated into whole cells.  

UK PubMed Central (United Kingdom)

Methanobacterium thermoautotrophicum, M. ruminantium, and Methanosarcina barkeri were labeled with 14CO2 (14CO2 + H14CO3- + 14CO32-) for from 2 to 45 s. Radioactivity was recovered in coenzyme M derivatives,...Full Text Available

1978-10-01

457

Molecular recognition of nitrated fatty acids by PPAR[gamma  

Energy Technology Data Exchange (ETDEWEB)

Peroxisome proliferator activated receptor-{gamma} (PPAR{gamma}) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPAR{gamma} ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPAR{gamma}. Structural and functional studies of receptor-ligand interactions reveal the molecular basis of PPAR{gamma} discrimination of various naturally occurring fatty acid derivatives.

2010-03-08

458

Model of blood-brain transfer of oxygen explains nonlinear flow-metabolism coupling during stimulation of visual cortex.  

DEFF Research Database (Denmark)

The coupling between cerebral metabolic rate of oxygen (CMRO2) and blood flow (CBF) in response to visual stimulation was evaluated by means of a model of oxygen delivery. The model predicted a nonlinear relationship between stimulus-evoked changes of oxygen consumption and blood flow. The magnitude of the CMRO2/CBF ratio index (IO2) was used to indicate the degree of flow-metabolism coupling prevailing in specific areas of the brain during physiological stimulation. Therefore, the index provided a measure of the blood oxygenation level dependent (BOLD) magnetic resonance contrast. To evaluate the changes of IO2 in response to visual stimulation, the model was applied to the effect of a changing flicker rate of a visual stimulus on the magnitudes of CBF, CMRO2, and oxygen diffusion capacity, in the human brain. Positron emission tomography (PET) was used to measure the CBF and the CMRO2 in 12 healthy volunteers who viewed a cross-hair ...

2000-01-01

459

Metabolism of Indole-3-Acetic Acid by Pericarp Discs from Immature and Mature Tomato (Lycopersicon esculentum Mill) 1  

UK PubMed Central (United Kingdom)

[1′-14C, 13C6]Indole-3-acetic acid was infiltrated into immature pericarp discs from fruits of tomato (Lycopersicon esculentum Mill., cv Moneymaker)....Full Text Available

1992-11-01

460

Metabolism of 4-chloro-2-methylphenoxyacetate by a soil pseudomonad. Ring-fission, lactonizing and delactonizing enzymes  

UK PubMed Central (United Kingdom)

1. A cell-free system, prepared from Pseudomonas N.C.I.B. 9340 grown on 4-chloro-2-methylphenoxyacetate (MCPA) was shown to catalyse the reaction sequence: 5-chloro-3-methylcatechol...Full Text Available

1971-05-01

461

Metabolism and Synthesis of Indole-3-Acetic Acid (IAA) in Zea mays (Levels of IAA during Kernel Development and the Use of in Vitro Endosperm Systems for Studying IAA Biosynthesis).  

UK PubMed Central (United Kingdom)

Kernels of Zea mays on an intact plant accumulate indole-3-acetic acid (IAA) at the rate of 190 ng g-1 fresh weight h-1. Of the IAA synthesized, 97% is in the esterified form and less than 3% remains...Full Text Available

1994-09-01

462

Metabolic effects of microwave radiation and convection heating on human mononuclear leukocytes. Final report, January 1985-May 1986  

Energy Technology Data Exchange (ETDEWEB)

Investigated here were the effects of microwave (MW) radiation (2450-MHz, continuous-wave, mean specific absorption rate of 103.5 + or - 4.2 W/kg) and convention heating on the nonphosphorylating oxidative metabolism of human peripheral mononuclear leukocytes (96% lymphocytes, 4% monocytes) at 37 C. Metabolic activity, determined by chemiluminescence (CL) of cells challenged with luminol (5-aminO-2, 3-dihydro-1, 4-phthalazinedione) linked to bovine serum albumin, was detected with a brightness photomer. A significant stimulation after after MW exposure (p < 0.005) over total CL of matched 37 C-incubator controls was observed. A similar degree of stimulation, compared to incubator controls, was also detected after sham treatment. No significant difference existed between changes in total CL or stimulation indices of the MW and sham-exposed groups. Exposure to MW radiation, under normothermic (37 + or - 0.03 C) conditions, appears to have no ...

1986-01-01

463

Isotope effects on the metabolism and pulmonary toxicity of butylated hydroxytoluene in mice by deuteration of the 4-methyl group  

Energy Technology Data Exchange (ETDEWEB)

A comparative test in mice for pulmonary toxicity between butylated hydroxytoluene (2,6-di-tert.-butyl-4-methylphenol, BHT) and 2,6-di-tert.-butyl-4-(alpha, alpha, alpha-2H3)methylphenol (BHT-d3) showed a significantly lower toxic potency of the latter. The rate of in vitro BHT metabolism to 2,6-di-tert.-butyl-4-methylene-2,5-cyclohexadienone (BHT-QM) was slowed by deuterating BHT in the 4-methyl group. On the other hand, the rate of in vitro metabolism to 2,6-di-tert.-butyl-4-hydroxy-4-methyl-2,5-cyclohexadienone (BHT-OH) was increased with the deuteration. A similar isotope effect of the deuterium substitution on the in vivo metabolic rates of BHT was observed. These observations support the concept that the lung damage caused by BHT is mediated by BHT-QM. The pulmonary toxicity of 2-tert.-butyl-4-ethylphenol (4-EP) and their deuterated analogs was also compared. 2-tert.-Butyl-4-(1,1-2H2)ethylphenol (4-EP-d2) showed a ...

1983-06-30

464

Iodine nutrition and risk of thyroid irradiation from nuclear accidents  

International Nuclear Information System (INIS)

The objectives of this paper are to discuss the following aspects of physiopathology of iodine nutrition related to thyroid irradiation by nuclear accidents: (1) The cycle of iodine in nature, the dietary sources of iodine and the recommended dietary allowances for iodine. (2) The anomalies of thyroid metabolism induced by iodine deficiency. The caricatural situation as seen in endemic goitre will be used as mode. (3) The specific paediatric aspects of adaptation to iodine deficiency. (4) The present status of iodine nutrition in Europe. (author).

465

Internalized insulin-receptor complexes are unidirectionally translocated to chloroquine-sensitive degradative sites. Dependence on metabolic energy  

Energy Technology Data Exchange (ETDEWEB)

Insulin receptors on the surface of isolated rat adipocytes were photoaffinity labeled at 12 degrees C with the iodinated photoreactive insulin analogue, 125I-B2 (2-nitro-4-azidophenylacetyl)-des-PheB1-insulin, and the pathways in the intracellular processing of the labeled receptors were studied at 37 degrees C. During 37 degrees C incubations, the labeled 440-kDa insulin receptors were continuously internalized (as assessed by trypsin inaccessibility) and degraded such that up to 50% of the initially labeled receptors were lost by 120 min. Metabolic poisons (0.125-0.75 mM 2,4-dinitrophenol (DNP) and 1-10 mM NaF), which led to dose-dependent depletion of adipocyte ATP pools, inhibited receptor loss, and caused up to 3-fold increase in intracellular receptor accumulation. This effect was due to inhibition of intracellular receptor degradation, and there was no apparent effect of the metabolic poisons on initial internalization of the receptors. ...

1988-04-25

466

Folate fortification of rice by metabolic engineering  

British Library Electronic Table of Contents (United Kingdom)

Rice, the world's major staple crop, is a poor source of essential micronutrients, including folates (vitamin B9). We report folate biofortification of rice seeds achieved by overexpressing two Arabidopsis thaliana genes of the pterin and para-aminobenzoate branches of the folate biosynthetic pathway from a single locus. We obtained a maximal enhancement as high as 100 times above wild type, with 100 g of polished raw grains containing up to four times the adult daily folate requirement.

2007-01-01

467

Expression of Genes Encoding F1-ATPase Results in Uncoupling of Glycolysis from Biomass Production in Lactococcus lactis  

UK PubMed Central (United Kingdom)

We studied how the introduction of an additional ATP-consuming reaction affects the metabolic fluxes in Lactococcus lactis. Genes encoding the hydrolytic part of the F1 domain...Full Text Available

2002-09-01

468

Enantioselective Transformation of ?-Hexachlorocyclohexane by the Dehydrochlorinases LinA1 and LinA2 from the Soil Bacterium Sphingomonas paucimobilis B90A  

UK PubMed Central (United Kingdom)

Sphingomonas paucimobilis B90A contains two variants, LinA1 and LinA2, of a dehydrochlorinase that catalyzes the first and second steps in the metabolism of hexachlorocyclohexanes (R....Full Text Available

2005-12-01

469

Effects of Perinatal PBDE Exposure on Hepatic Phase I, Phase II, Phase III, and Deiodinase 1 Gene Expression Involved in Thyroid Hormone Metabolism in Male Rat Pups  

UK PubMed Central (United Kingdom)

Previous studies demonstrated that perinatal exposure to polybrominated diphenyl ethers (PBDEs), a major class of brominated flame retardants, may affect thyroid hormone (TH) concentrations by inducing...Full Text Available

2009-01-01

470

Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates  

UK PubMed Central (United Kingdom)

Cytochrome P450 1B1 (Cyp1b1) metabolism contributes to physiological functions during embryogenesis, but also to carcinogenic activation of polycyclic aromatic hydrocarbons (PAH). We generated...Full Text Available

2008-09-15

471

Cloning and sequencing of a 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase gene involved in the degradation of gamma-hexachlorocyclohexane in Pseudomonas paucimobilis.  

UK PubMed Central (United Kingdom)

In Pseudomonas paucimobilis UT26, gamma-hexachlorocyclohexane (gamma-HCH) is converted to 2,5-dichloro-2,5-cyclohexadiene-1,4-diol (2,5-DDOL), which is then metabolized to 2,5-dichlorohydroquinone....Full Text Available

1994-06-01

472

Characterization and Rooting Ability of Indole-3-Butyric Acid Conjugates Formed during Rooting of Mung Bean Cuttings 1  

UK PubMed Central (United Kingdom)

Indole-3-butyric acid (IBA) is rapidly metabolized by mung bean cuttings during rooting. Twenty-four hours after application, less than 20% of the applied IBA remained in the free form and its level...Full Text Available

1989-11-01

473

Bibliographic study on molybdenum biokinetics. Literaturstudie zur Biokinetik von Molybdaen  

Energy Technology Data Exchange (ETDEWEB)

This bibliographical study compiles and analyzes findings about the metabolism and resorption of molybdenum. Besides including studies on the physiology of molybdenum 99, a general survey is given on molybdenum in the environment and on its physiological behaviour. In particular, information on the dependence of molybdenum resorption on various factors, such as the chemical form, antagonisms etc., are gathered from literature. These factors have to be considered for sensibly carrying out necessary experiments.

1988-05-01

474

Alterations in Adenylate Kinase Activity in Human PBMCs after In Vitro Exposure to Electromagnetic Field: Comparison between Extremely Low Frequency Electromagnetic Field (ELF) and Therapeutic Application of a Musically Modulated Electromagnetic Field (TAMMEF)  

UK PubMed Central (United Kingdom)

This study investigated the effects of electromagnetic fields on enzymes involved in purine metabolism in human peripheral blood mononuclear cells in vitro. Cells were obtained from 20 volunteers. We...Full Text Available

2009-01-01

475

Action of Inhibitors of Ammonia Assimilation on Amino Acid Metabolism in Hordeum vulgare L. (cv Golden Promise) 1  

UK PubMed Central (United Kingdom)

Barley (Hordeum vulgare L. cv Golden Promise) plants were grown in a continuous culture system in which the root and shoot ammonia and amino acid levels were constant over a 6-hour...Full Text Available

1983-03-01

476

Recreating wetland ecosystems in an oil sands disturbed landscape : Suncor consolidated-tailings demonstration wetlands  

Energy Technology Data Exchange (ETDEWEB)

Open pit oil sands mining involves the disturbance of thin overburden covers of Boreal forest lands that must be returned to equivalent land capability after mining activities have ceased. Before mining starts, any wetlands are drained, timber is harvested, and peat, topsoils and subsoils are stockpiled for later use. This article discussed wetland reclamation activities conducted by Suncor Energy at its open pit mining operations. Research facilities were constructed in order to determine if wetlands constructed with consolidated tailings (CT) and pond effluent water (PEW) were able to support a sustainable vegetation community. Thirty-three cat-tail plots were established at the facility as well as unplanted plots in order to determine how quickly natural establishment occurred. Shoreline plug transplants and transplants from a natural saline lake were also introduced. Within 5 years, over 23 plant species had naturally colonized the CT wetlands. However, ...

2009-10-01

477

Program plan for development of underground hydroelectric pumped storage technology  

Science.gov (United States)

The Underground Hydroelectric Pumped Storage (UHPS) Program Plan describes in detail the planned activities and expected accomplishments in the conduct of UHPS technology development and validation envisioned in the 1976 to 1990 time frame. This document describes the program objectives, implementation strategy, and management methodology. The concept of underground hydroelectric pumped storage is fully directed to application in the electric utility industry. This technology involves using electrical energy generated by base-load plants during off-peak load periods to drive a high-head pump/turbine which pumps water from a lower reservoir to a substantially elevated (upper) reservoir corresponding to a head of 1000 m or so. The upper reservoir is at ground level and the lower reservoir is below ground. Then, during peak-load periods, water in the upper reservoir is allowed to flow to the lower reservoir which, in turn, drives a hydraulic turbine for power generation. Intermediate ...

1976-03-01

478

Obsidian from volcanic sequences and rent alluvial deposits, Erzurum district, north-eastern Anatolia: Chemical characterisation and archaeological implications  

Energy Technology Data Exchange (ETDEWEB)

Full text: Recent geoarchaeological research in the Erzurum district, north-eastern Anatolia, has revealed an abundance of obsidian at numerous neolithic and Bronze Age sites. Geochemical characterisation using neutron activation analysis indicates that the obsidian was obtained from several sources that are chemically distinct from the major sources already known from Central Anatolia an the Lake Van area. Multiple sources are represented in the samples collected from at least two of the sites, namely the sites of Sos and Pulur. The primary source of some of the obsidian utilised at the site of Sos has been located in the volcanic sequence outcropping tot he north-west of Pasinler. Field survey however has shown that the alluvial deposits along the main rivers and some of their tributaries were the main sources of the obsidian utilised at the sites near Erzurum. Trade or exchange of obsidian with sites outside the Erzurum area seems to have been limited.

1997-12-31

479

Methods and results of an evaluation of aquatic receptor risk at the Rocky Flats Environmental Technology Site, Golden, Colorado  

International Nuclear Information System (INIS)

The Rocky Flats Environmental Technology Site (RFETS) has historically released radionuclide chemicals of potential concern into the surrounding environment. The off-site environment was evaluated for Pu"2"3"9"/"2"4"0 and Am"2"4"1 occurrence. An evaluation of exposure and effects to the aquatic ecology within off-site areas including: Standley Lake, Great Western Reservoir, Mower Reservoir and portions of Big Dry Creek, Walnut Creek, and Woman Creek was performed for the completion of an Ecological Risk Assessment. Collocated sampling activities were performed for surface water, sediment, benthic macroinvertebrates and fish. Results of the analytical data were used to assess ongoing exposure and effects. Data collected to determine effects (chemical content of fish tissue, diversity and density of macroinvertebrate populations) provided some of the necessary information needed to evaluate risk. However, due to conditions of interfering stressor effects, a ...

1995-11-05

480

Methanogens and sulfate-reducing bacteria in oil sands fine tailings waste.  

Science.gov (United States)

In the past decade, the large tailings pond (Mildred Lake Settling Basin) on the Syncrude Canada Ltd. lease near Fort McMurray, Alta., has gone methanogenic. Currently, about 60%-80% of the flux of gas across the surface of the tailings pond is methane. As well as adding to greenhouse gas emissions, the production of methane in the fine tailings zone of this and other settling basins may affect the performance of these settling basins and impact reclamation options. Enumeration studies found methanogens (10(5)-10(6) MPN/g) within the fine tailings zone of various oil sands waste settling basins. SRB were also present (10(4)-10(5) MPN/g) with elevated numbers when sulfate was available. The methanogenic population was robust, and sample storage up to 9 months at 4 degrees C did not cause the MPN values to change. Nor was the ability of the consortium to produce methane delayed or less efficient after storage. Under laboratory conditions, fine tailings samples ...

2000-10-01

481

Measurement of oxidation rate of sulfite in rain water in Yokohama, Japan  

Energy Technology Data Exchange (ETDEWEB)

In recent years, the influences of acid rain such as the acidification of lake water, on bio-system by the heavy metals from effluent of soils with acid rain and also on the structural materials of buildings are seriously discussed. Sulfur and nitrogen that are contained in fossil fuels are released into the atmosphere by the fuel combustion as their oxides dissolve in rain drops as sulfite and nitrous ions, where they are further oxidized into sulfate and nitrate ions These ions lower the pH of rain water resulting so-called acid rain. Therefore, it is important to accurately determine these ions in rain water for the investigation of reality of acid rain. However, it is not easy to accurately determine these ions, especially for sulfite ions in rain water, since they are quickly oxidized by the catalytic action of metallic ions such as ferric and manganous ions. And light, temperature, pH of solution and also species and concentrations of dissolved metallic ions ...

1986-04-01

482

Macrofouling control in nuclear power plants  

International Nuclear Information System (INIS)

Macrofouling of cooling-water systems is one of the more significant and costly problems encountered in the nuclear power industry. Both marine and freshwater macroinvertebrates can be responsible for losses in plant availability because of plugged intakes and heat transfer equipment. There is a greater diversity of macrofouling organisms in marine waters than in fresh waters. Marine macrofouling organisms include barnacles, mollusks, bryozoans, and hydroids. Barnacles are crustaceans with feathery appendages, which allow them to attach to a variety of surfaces. They are a major cause of severe macrofouling because they can remain attached even after death. The major freshwater macrofouling organisms include the Asiatic Clam (Corbicula fluminea) and the newest freshwater macrofouler, the Zebra Mussel (Dreissena polymorpha). The introduction of the Zebra Mussel into the Great Lakes has created economic and ecological problems that will not easily be solved. The ...

1991-11-10

483

Interfaces in aquatic ecosystems: Implications for transport and impact of anthropogenic compounds  

Energy Technology Data Exchange (ETDEWEB)

Mechanisms that govern transport, accumulation and toxicity of persistent pollutants at interfaces in aquatic ecosystems were the foci of this thesis. Specific attention was paid to humic substances, their occurrence, composition, and role in exchange processes across interfaces. It was concluded that: The composition of humic substances in aquatic surface microlayers is different from that of the subsurface water and terrestrial humic matter. Levels of dissolved organic carbon (DOC) in the aquatic surface microlayer reflect the DOC levels in the subsurface water. While the levels and enrichment of DOC in the microlayer generally show small variations, the levels and enrichment of particulate organic carbon (POC) vary to a great extent. Similarities exist between aquatic surface films, artificial semi-permeable and biological membranes regarding their structure and functioning. Acidification and liming of freshwater ecosystems affect DOC:POC ratio and humic composition of the surface ...

1996-11-01

484

Hydroelectric power in Switzerland: large growth potential by increasing the installed power  

International Nuclear Information System (INIS)

Due to its important hydroelectric power generation facilities (about 525 plants with a total power of 13,314 MW producing about 35.3 TWh annually) Switzerland plays an important role in the interconnected European power system. Large artificial storage lakes in the Swiss Alps can generate peak power during hours of highest demand: 9700 MW are available from accumulated energy and the total power of pumped-storage facilities amounts to 1700 MW. The latter allow refilling the reservoirs at periods of low power demand and generating power at periods of peak demand. In the case of favorable conditions, the yearly average power production could be increased by 6% and the production during the winter period (October to March) by 20% by the year 2020. However, looking forward to the year 2050, the annual production is expected to decrease by 3% despite a possible extension of hydropower. This decrease is due to the enforcement of the minimum residual water flow rates ...

485

Flows for Floodplain Forests: A Successful Riparian Restoration  

Science.gov (United States)

This peer-reviewed article from Bioscience journal is about restoring the Truckee river.Throughout the 20th century, the Truckee River that flows from Lake Tahoe into the Nevada desert was progressively dammed and dewatered, which led to the collapse of its aquatic and riparian ecosystems. The federal designation of the endemic cui-ui sucker (Chasmistes cujus) as endangered prompted a restoration program in the 1980s aimed at increasing spring flows to permit fish spawning. These flows did promote cui-ui reproduction, as well as an unanticipated benefit, the extensive seedling recruitment of Fremont cottonwood (Populus fremontii) and sandbar willow (Salix exigua). Recruitment was scattered in 1983 but extensive in 1987, when the hydrograph satisfied the riparian recruitment box model that had been developed for other rivers. That model was subsequently applied to develop flow prescriptions that were implemented from 1995 through 2000 and enabled further seedling ...

2003-07-01

486

Evidence and Implications of Frequent Fires in Ancient Shrub Tundra  

Energy Technology Data Exchange (ETDEWEB)

Understanding feedbacks between terrestrial and atmospheric systems is vital for predicting the consequences of global change, particularly in the rapidly changing Arctic. Fire is a key process in this context, but the consequences of altered fire regimes in tundra ecosystems are rarely considered, largely because tundra fires occur infrequently on the modern landscape. We present paleoecological data that indicate frequent tundra fires in northcentral Alaska between 14,000 and 10,000 years ago. Charcoal and pollen from lake sediments reveal that ancient birchdominated shrub tundra burned as often as modern boreal forests in the region, every 144 years on average (+/- 90 s.d.; n = 44). Although paleoclimate interpretations and data from modern tundra fires suggest that increased burning was aided by low effective moisture, vegetation cover clearly played a critical role in facilitating the paleo-fires by creating an abundance of fine fuels. These records suggest ...

2008-03-06

487

Eielson Air Force Base Operable Unit 2 baseline risk assessment  

Energy Technology Data Exchange (ETDEWEB)

Operable Unit 2 at Eielson Air Force Base (AFB) near Fairbanks, is one of several operable units characterized by petroleum, oil, and lubricant contamination, and by the presence of organic products floating at the water table, as a result of Air Force operations since the 1940s. The base is approximately 19,270 acres in size, and comprises the areas for military operations and a residential neighborhood for military dependents. Within Operable Unit 2, there are seven source areas. These source areas were grouped together primarily because of the contaminants released and hence are not necessarily in geographical proximity. Source area ST10 includes a surface water body (Hardfill Lake) next to a fuel spill area. The primary constituents of concern for human health include benzene, toluene, ethylbenzene, and xylenes (BTEX). Monitored data showed these volatile constituents to be present in groundwater wells. The data also showed an elevated level of trace metals in ...

1994-10-01

488

Effect of planktivores, zooplankton, and macrobenthos on material flow in a small lake  

International Nuclear Information System (INIS)

Planktivores, zooplankton grazers, and macrobenthos were studied to determine how changes in animal community structure may alter the flow of material in Dunham Pond, CT. Chaoborus and chironomid larvae were studied to determine how they affect the flux of matter across the sediment/water interface. This was done by incubating undisturbed cores in situ and relating changes in water chemistry to larval density. The log-transformed flux rates of iron, manganese, and phosphorus were linearly related to larval biomass. Functional groups may be successfully used to predict rates of material flow. Changes in the mass of macroinvertebrates affect the flux rates of redox-active substances across the sediment/water interface. The use of population densities and feeding characteristics to estimate trophic transfer in Dunham Pond indicate that (1) visual planktivory by larval perch may result in overutilization of prey, (2) ambush planktivory by univoltine Chaoborus appears to under utilize prey, ...

489

Dilute chemical cleaning of PWR steam generators off-line cleaning process evaluation  

Energy Technology Data Exchange (ETDEWEB)

This project evaluated the feasibility of using a low-concentration (approx. 0.5 wt %) chemical cleaning process to remove corrosion product deposits from steam generator surfaces and magnetite from tube-to-support plate crevices of PWR steam generators. The primary objective was to develop a dilute process that could be safely applied at scheduled intervals, such as during normal refueling outages, to maintain a clean operating condition in the steam generator. The dilute chemical cleaning process developed in this project was demonstrated successfully on two model generators which were operated on faulted chemistry by DOE/CRC at Commonwealth's State Line Facility. Unit 5 was cleaned after 48 days of operation with 1% seawater fouling, and Unit 6 was cleaned after 112 days of operations with Lake Michigan water. This report describes work leading to the model generator cleaning demonstrations and provides details of the cleaning operation for each model ...

1983-07-01

490

Dilute chemical cleaning of PWR steam generators off-line cleaning process evaluation  

International Nuclear Information System (INIS)

This project evaluated the feasibility of using a low-concentration (approx. 0.5 wt %) chemical cleaning process to remove corrosion product deposits from steam generator surfaces and magnetite from tube-to-support plate crevices of PWR steam generators. The primary objective was to develop a dilute process that could be safely applied at scheduled intervals, such as during normal refueling outages, to maintain a clean operating condition in the steam generator. The dilute chemical cleaning process developed in this project was demonstrated successfully on two model generators which were operated on faulted chemistry by DOE/CRC at Commonwealth's State Line Facility. Unit 5 was cleaned after 48 days of operation with 1% seawater fouling, and Unit 6 was cleaned after 112 days of operations with Lake Michigan water. This report describes work leading to the model generator cleaning demonstrations and provides details of the cleaning operation for each model steam ...

491

Development of a generic analysis code of dynamic compartment model for evaluation of doses in terrestrial biosphere  

International Nuclear Information System (INIS)

The release rate of a nuclide from a reactor or a radioactive waste disposal plant at the accident is not steady, but varies with time. The various parameters of a nuclide migration into environment vary also day after day, or with the seasons. In such cases, dynamic behavior of the nuclide in the environment must be taken into consideration. It is difficult for a mathematical model to involve all of mechanisms for the nuclide migration. The environment for evaluation of doses are usually divided into some of compartments in which a nuclide concentration is uniform. Time variations of the nuclide concentration in the compartment are described in simultaneous differential equations. The nuclide concentration can be solved as a time function, and the radiation doses, therefore, can be estimated as a time function. Generic analysis code for dynamic compartment model (GACOM) is developed for the nuclide migration and the evaluation of doses in terrestrial biosphere. The code contains many ...

1999-02-01

492

Coal compilation project - Moberly Creek NTS 83E/9  

Energy Technology Data Exchange (ETDEWEB)

The primary purpose of the pilot Coal Compilation Project is to provide coal resource maps to stimulate and support industry exploration programs and to assist government in matters of resource management. An essential feature of the program is the use of cost effective Geoscience Information System (GSIS) technology that allows the database and various thematic maps to be analysed, updated and displayed with complete flexibility at any scale. This report describes the main features (geology, resource management, exploration history, coal occurrences etc.) of the study area, mapsheet NTS 83E/9 (Moberly Creek), and includes a copy of the 1:50,000 scale map produced. The study area is located in West-central Alberta and contains coal measures deposited amid thick successions of sandstones, siltstones, shales and conglomerates. These coal-bearing sequences are part of the Luscar Group, Upper Cretaceous Brazeau Formation and Paleocene Coalspur Formations. Coal seams have been identified ...

1990-01-01

493

Changes in aerobic digester performance with the use of methanol for biological nutrient removal in a full-scale sequencing batch reactor  

Energy Technology Data Exchange (ETDEWEB)

Increasingly, governments enact more stringent regulations governing nitrogen and phosphorus in the discharge effluent of wastewater treatment plants. Scientists know that nitrogen and phosphorus accelerates the eutrophication of lakes and reservoirs and stimulates algal growth. Ammonia has proven to be toxic to aquatic life forms, including fish. Engineers favour Biological Nutrient Removal (BNR) over chemical addition to wastewater treatment. Sequencing Batch Reactors (SBRs), a type of bioreactor requiring less land, provide the anaerobic, anoxic, and aerobic zones necessary for BNR. Methanol was used as an effective external source of carbon for denitrification but lacked research. The authors remedied this situation and some of the results were available. They indicated that the addition of methanol in the SBR increased solids production in the SBR, leading to increased sludge wasting to the aerobic digester. All aspects of the sludge digester performance that ...

2000-07-01

494

Application of space imagery for the study of anthropogenic pollution and its impact on the environment  

Energy Technology Data Exchange (ETDEWEB)

The implementation of satellite remote sensing data for monitoring anthropogenic pollution in the USSR is described. Space-based monitoring systems offer the opportunity to identify pollution sources, track the spread of pollutants on the surface and in the air, and characterize land use patterns that cause erosion. Furthermore, vegetation under attack by polluting agents can be recognized by color changes, and water pollution in lakes, coastal zones, and in rivers near industrial areas and ports can be measured for the total affected area. The data have thus far been taken with instrumentation on board the Salyut space station, the Meteor-Priroda satellite, and from the Landsat MSS scanner. It is noted that the transboarder transport of pollutants necessitates sharing data with agencies of other nations, and that a data base must be developed to define procedures and instrumentation for given pollutants, algorithms for processing the data, and discern man-made ...

1983-01-01

495

Uranium-lead zircon ages from the Median Tectonic Zone, New Zealand  

International Nuclear Information System (INIS)

The Median Tectonic Zone (MTZ) of New Zealand is a generally north trending belt of Mesozoic subduction related I-type plutonic, volcanic, and sedimentary rocks in South Island and Stewart Island that separates Permian strata of the Eastern Province Brook Street Terrane from lower to mid Gondwana margin assemblages of the Western Province. High precision isotope dilution U/Pb ages of zircons from 30 rocks are reported. Pre-digestion leaching of zircon in hydrofluoric acid yielded significantly more concordant residues by removing common Pb and dissolving more soluble high-U domains that have been more affected by relatively recent Pb loss. The results show that MTZ magmatism ranges in age from at least Early Triassic to Early Cretaceous (247-131 Ma), with a pronounced gap in the Middle Jurassic. Triassic plutons tend to occur on the eastern side of the MTZ, and they intrude volcanic/sedimentary sequences of the MTZ in Nelson and eastern Fiordland. These sequences are in turn intruded ...

496

Land uplift and relative sea-level changes in the Loviisa area, southeastern Finland, during the last 8000 years  

Energy Technology Data Exchange (ETDEWEB)

Southeastern Finland belongs to the area covered by the Weichselian ice sheet, where the release of the ice load caused a rapid isostatic rebound during the postglacial time. While the mean overall apparent uplift is of the order of 2 mm/yr today, in the early Holocene time it was several times higher. A marked decrease in the rebound rate occurred around 8500 BP, however, since then the uplift rate has remained high until today, with a slightly decreasing trend towards the present time. According to current understanding there have neither been temporary increases nor decreases in the rate of uplift during the postglacial time. Even so, it is not known for sure whether there are regional irregularities on the rebound in Finland. Concurrently with land uplift, relative sea-level changes in the Baltic basin were also strongly affected by the global eustatic rise of sea-level. During the early Litorina Sea stage on the southern coast of Finland around 7000 BP, the rise in sea-level ...

1999-09-01

497

Investigation of flora and fauna species of Lake Baikal by electron-probe microanalysis  

International Nuclear Information System (INIS)

Complete text of publication follows. Baikal is an ancient unique lake. The sweet water of Baikal is crystal clean; it concentrates oxygen and contains scarce silicon. This feature is provoked very particular interest for scientists and poses some awkward questions concerning the preservation of Baikal's ecosystem. A profound investigation of fish otholiths, animal teeth, sponges, valves of mollusks and diatom algae provides chronological information, possibility to reconstruct the events proceeding in the environment based on variations of their chemical composition. Because these study objects are small-sized, and some of them are micron-size, application of the electron-probe microanalysis turns to be quite productive. The goal of this study is to disclose performance capabilities of this method while investigating the Baikal flora and fauna. Investigations were performed by devices JCXA-733 and JXA-8200 using the electron microscope and x-ray microprobe modes. ...

498

Nuclear factor of activated T cell (NFAT) transcription proteins regulate genes involved in adipocyte metabolism and lipolysis  

Science.gov (United States)

NFAT involvement in adipocyte physiological processes was examined by treatment with CsA and/or GSK3{beta} inhibitors (Li{sup +} or TZDZ-8), which prevent or increase NFAT nuclear translocation, respectively. CsA treatment reduced basal and TNF{alpha}-induced rates of lipolysis by 50%. Adipocytes preincubated with Li{sup +} or TZDZ-8 prior to CsA and/or TNF{alpha}, exhibited enhanced basal rates of lipolysis and complete inhibition of CsA-mediated decreased rates of lipolysis. CsA treatment dramatically reduced the mRNA levels of adipocyte-specific genes (aP2, HSL, PPAR{gamma}, ACS and Adn), compared with control or TNF{alpha}-treatment, whereas Li{sup +} pretreatment blocked the inhibitory effects of CsA, and mRNA levels of aP2, HSL, PPAR{gamma}, and ACS were found at or above control levels. NFAT nuclear localization, assessed by EMSA, confirmed that CsA or Li{sup +} treatments inhibited or increased NFAT nuclear translocation, respectively. These results show that NFAT proteins in ...

2007-09-21

499

Mechanisms of renal handling of lead  

International Nuclear Information System (INIS)

The relative roles of glomerular filtration, tubular reabsorption and tubular secretion in lead handling were evaluated using renal clearance technique, stop-flow analysis, and renal lead accumulation. In addition, the effect of altering acid-base status on renal handling of Pb was determined. Clearance of ultrafilterable lead was measured in anesthetized dogs during infusion of "2"0"3Pb with small doses of carrier Pb(0.5 to 50 #mu#g/kg/h). Filterable lead concentration was estimated by in vitro ultrafiltration of non-anticoagulated plasma. Fractional excretion of Pb was calculated using creatinine clearance to estimate glomerular filtration rate. Dogs in acute metabolic acidosis had the lowest fractional excretion of ultrafilterable Pb (< 0.1); those in alkalosis had high fractional Pb excretion (0.75 to 2.5) while normal dogs were intermediate (0.1 to .4). The fractional excretion of Pb during metabolic alkalosis varied with the dose of Pb ...

500

Erratum to: Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica  

British Library Electronic Table of Contents (United Kingdom)

A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of drug metabolism. The cytochrome P450 (CYP 450) enzyme pathway was inhibited using ketoconazole (KTZ) to see whether a TCBZ-resistant isolate could be made more sensitive to TCBZ action. The Oberon TCBZ-resistant and Cullompton TCBZ-susceptible isolates were used for these experiments. The CYP 450 system was inhibited by a 2-h pre-incubation in ketoconazole (40??M), then incubated for a further 22?h in NCTC medium containing either KTZ, KTZ?+?nicotinamide adenine dinucleotide phosphate (NADPH) (1?nM), KTZ?+?NADPH?+?TCBZ (15??g/ml), or KTZ?+?NADPH?+?triclabendazole sulphoxide (TCBZ.SO; 15??g/ml). Changes to fluke ultrastructure following drug treatmen...

2011-01-01