lacz transduced human: Topics by WorldWideScience.org

Four of seven human male subjects developed full penile erections when exposed to erotically stimulating motion pictures. Changes in penile size were detected by a mercury strain gauge transducer and...Full Text Available

1969-01-01

3

TEMPERATURE TRANSDUCERS: WHAT'S COOKING?

BackgroundA large fraction of the human genome is attributable to L1 retrotransposon sequences. Not only do L1s themselves make up a significant portion of the genome, but L1-encoded...Full Text Available

2003-01-01

4

A Method for Accurate in silico modeling of Ultrasound Transducer Arrays

... Accession Number : ADD874310. Title : TEMPERATURE TRANSDUCERS: WHAT'S COOKING? Corporate Author : Personal ...

1979-05-01

5

Characterization of medical piezoelectric ultrasound transducers using pulse echo methods.

This paper presents a new approach to improve the in silico modeling of ultrasound transducer arrays. While current simulation tools accurately predict the theoretical element...Full Text Available

2009-05-01

6

Norwegian Open Research Archives (NORA)

Full Text Available

7

Modulation of neuronal differentiation by CD40 isoforms

Photoacoustic imaging using an ultrasonic Fresnel zone plate transducer

Neuron differentiation is a complex process involving various cell-cell interactions, and multiple signaling pathways. We showed previously that CD40 is expressed and functional on mouse and human neurons. In neurons, ligation of CD40 protects against serum withdrawal-induced injury and plays a role in survival and differentiation. CD40 deficient mice display neuron dysfunction, aberrant neuron morphologic changes, and associated gross brain abnormalities. Previous studies by Tone and colleagues suggested that five isoforms of CD40 exist with two predominant isoforms expressed in humans: signal-transducible CD40 type I and a C-terminal truncated, non-signal-transducible CD40 type II. We hypothesized that differential expression of CD40 isoform type I and type II in neurons may modulate neuron differentiation. Results show that adult wild-type, and CD40"-"/"- deficient mice predominantly express CD40 ...

2008-05-02

8

Acoustic transducer for acoustic microscopy

A photoacoustic (PA) imaging system based on an ultrasonic Fresnel zone plate (FZP) transducer is developed for the purpose of imaging biological tissue. This FZP transducer has a two-zone negative zone plate piezoelectric material pattern, and an optical fibre is integrated with the transducer on the symmetric axis of the zone plates to deliver laser pulses to the sample. The focal characteristic of the FZP transducer is analysed by theoretical prediction and experimental measurement, and the measured results are in good agreement with the predicted results. The limited-field back-projection deconvolution algorithm combined with the coherence-factor weighting technique is used to reconstruct the optical absorption distribution. The experiments were performed with phantoms and the blood vessels of chicken embryo chorioallantoic membrane. The results demonstrate that PA imaging using the FZP ...

2008-05-07

9

The protein truncation caused by fusion of PEP-1 peptide and protective roles of transduced PEP-1-MsrA in skin cells

A shear acoustic transducer-lens system in which a shear polarized piezoelectric material excites shear polarized waves at one end of a buffer rod having a lens at the other end which excites longitudinal waves in a coupling medium by mode conversion at selected locations on the lens.

1990-01-01

10

BUDGET ESTIMATES - NASA Headquarters

Full Text Available

2011-04-01

11

Ultrasonic piezoelectric transducer that forms a specified directivity pattern

extravehicular activity; an exploding bridgewire firing unit for rocket engines ; a pressure transducer that can withstand the 6000 OF temperiiture ...

12

Development of a methodology to assess organometallic effects on bioenergetic systems

Methods of designing ultrasonic piezoelectric transducers in accord with a specified directivity pattern are analyzed and general formulas are presented for the design problem. As an example, the pressure distribution on the working surface of a circular piezoelectric transducer is determined that is capable of forming a narrow weakly divergent beam. Experimental results are presented with respected to ultrasonic fields that support the theoretical conclusions.

1989-03-01

13

The Schenberg spherical antenna: status report

A methodology for assessing the impact of subacute concentrations of organometallic agents on bioenergetic and oxidative damage processes in animals, cells and energy transducing subcellular organelles is being developed. Several of the assays are noninvasive and thus lend themselves to human tests. At the whole-animal level we utilize a treadmill chamber where physiological parameters of exercising animals are monitored. These include parameters of whole animals' work performance such as oxygen consumption, carbon dioxide evolution and endurance. Oxidative damage can be monitored in experiments by analyzing expired air of the animals for ethane and n-pentane. These alkanes correlate with lipid peroxidation in vivo. At the cellular and subcellular levels, respiratory activity, lipid peroxidation and free radical species are assayed. Respiratory activity is measured in muscle homogenates and isolated mitochondria using substrates which ...

1981-06-01

14

Replication-defective vectors of reticuloendotheliosis virus transduce exogenous genes into somatic stem cells of the unincubated chicken embryo

Full text. Here we present a status report of the Schenberg antenna, which started commissioning runs in September 2006 under the full support of FAPESP. In its first commissioning runs we tested three preliminary parametric transducer systems, which did not achieve a high enough performance for placing the antenna sensitivity in the range of the calibrator capacitor. Instead of improving the calibrator, making it capable of introducing a larger input force, we decided to go to a radical upgrading operation: replacing the three transducers for a complete set of six transducers, with better sensitivity and arranged according to the truncated icosahedron configuration, plus two extra ones; starting to install the dilution refrigerator; installing wires, cables, and amplifiers for the complete set of transducer circuits; and a new suspension and vibration isolation system for the cabling and microstrip ...

2009-09-14

15

Optoelectronic multipoint liquid level sensor for light petrochemical products

Replication-defective vectors derived from reticuloendotheliosis virus were used to transduce exogenous genes into early somatic stem cells of the chicken embryo. One of these vectors transduced and expressed the chicken growth hormone coding sequence. The helper cell line, C3, was used to generate stocks of vector containing about 10/sup 4/ transducing units per ml. Injection of 5- to 20-..mu..l volumes of vector directly beneath the blastoderm of unincubated chicken embryos led to infection of somatic stem cells. Infected embryos and adults contained unrearranged integrated proviral DNAs. Embryos expressed the transduced chicken growth hormone gene and contained high levels of serum growth hormone. Blood, brain, muscle, testis, and semen contained from individuals injected as embryos contained vector DNA. Replication-defective vectors of the reticuloendotheliosis virus transduced ...

1989-06-01

16

Tests with superconducting re-entrant cavities for transducer applications in gravitational wave detectors

In this article we describe an optoelectronic sensor for assessing the level of light petrochemical products in technological tanks at the oil refineries. This sensor employs the multi-element vertical array of discrete micro- optical refractometric transducers. The transducers are made of silica glass and have the conical shape. In the air, each transducer operates as a tiny retro-reflector that optically couple together two multimode optical fibers. The optical coupling in the transducer is due to the internal reflection at the conical surface. The amount of the coupling depends on the refractive index of the surrounding media. In a fluid, the total internal reflection vanishes and the coupling becomes negligibly small. The number of immersed transducers is a measure of the fluid level in the reservoir. Because of the significance of the transducer ...

2000-06-01

17

SPACE STATION INTEGRATED WALL DESIGN AND PENETRATION

We studied the niobium re-entrant cavity utilized by the Australian group in the Niobe gravitational wave detector. Instead of using their non-contact re-entrant cavity, we plan to change it to a closed one to be used in the parametric transducers of the Brazilian Mario Schenberg detector. The performance of the transducer depends on some cavity parameters such as the electrical Q and the electrical coupling. We measured the resonant frequency and the loaded electrical Q as a function of the probe position in a closed niobium #approx#15 GHz cavity operating at 4.2 K.

2004-03-07

18

Machine condition monitoring - the way ahead

screens of fine wire was placed between the gun barrel and the panel to determine whether the gun performance was repeatable. The transducers were placed ...

19

Vector Velocity Imaging Using Cross-Correlation and Virtual Sources

During the last fifteen years a variety of instruments and transducers, such as voltage plugs, power transducers, flow and pressure transducers, recorders and tensometers, have been developed for underground use in measuring the performance and technical parameters of prototype machines. The equipment, until recently, has been in a portable form and was found useful by the industry generally, in fault finding and trouble-shooting exercises and in commissioning procedures performed by small teams on a call-out basis. Over the last five years the test equipment has been adapted and the techniques modified to suit individual colliery-based operations with more permanent machine mounted and built-in transducers. At the moment these techniques operate within the framework of a statutory planned preventive maintenance scheme for each mine. This paper discusses the merits of changing from preventive ...

1984-11-01

20

Two-phase flow regime observations in a vertical hexagonal flow channel with and without a finned fuel bundle

Previous investigations have shown promising results in using the directional cross-correlation method to estimate velocity vectors. The velocity vector estimate provides information on both velocity direction and magnitude. The direction is estimated by beamforming signals along directions in the range $[0^{\\circ}; 180^{\\circ}[$ and identifying the direction that produces the largest correlation across emissions. An estimate of the velocity magnitude is obtained from the spatial shift between signals beamformed along the estimated direction. This paper expands these investigations to include estimations of the vector velocities of a larger region by combining the estimations along several scan lines. In combination with a B-mode image, the vector velocities are displayed as an image of the investigated region with a color indicating the magnitude, and arrows showing the direction of the flow. Using the RASMUS experimental ultrasound scanner, measurements have been carried out in a ...

2006-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

21

The Induction of APC with a Distinct Tolerogenic Phenotype via Contact-Dependent STAT3 Activation

Previous flow regime studies have been for horizontal, vertical, and inclined pipe flow. As such, only a few studies have been performed on bundle geometries. The present paper examines the flow regimes for a vertical hexagonal flow channel with and without a finned fuel bundle. This type of a 36 finned rod hexagonal fuel bundle in parallel hexagonal flow channels is used in a MAPLE (Multi- purpose Applied Physics Lattice Experimental) type nuclear reactor. An experiment apparatus was designed consisting of the flow channel, inlet plenum and an air-water separator. The inlet plenum is used to provide a uniform mixture of air and water before entering the hexagonal flow channel. A turbine flow meter is used to determine the water flow rate. The turbine flow meter is calibrated for a low flow range and limits the measurable flow to 50 l/min. Flow pattern observation is determined by a SONY video camera, Real-Time Neutron Radiography, pressure transducer and ...

1990-12-10

22

Highly efficient concentration of lenti- and retroviral vector preparations by membrane adsorbers and ultrafiltration

BackgroundActivation of the signal transducer and activator of transcription 3 (STAT3) within antigen presenting cells (APCs) is linked to abnormal APCs differentiation and function....Full Text Available

23

Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation

BackgroundLentiviral vectors (LVs) can efficiently transduce a broad spectrum of cells and tissues, including dividing and non-dividing cells. So far the most widely used method...Full Text Available

24

Changes in colonic motility induced by sennosides in dogs: evidence of a prostaglandin mediation.

IntroductionTyrosine phosphorylated signal transducer and activator of transcription 3 (pStat3) is expressed in numerous cancers and is required for mediating tumorigenesis. Autocrine...Full Text Available

2010-01-01

25

Human cornea glycosaminoglycans

The effects of sennosides on colonic motility were investigated in eight conscious dogs chronically fitted with two strain gauge transducers in the proximal colon, an intracolonic silicone catheter...Full Text Available

1988-09-01

26

Onset of nucleate boiling and onset of fully developed subcooled boiling using pressure transducers signals spectral analysis

No abstract prepared.

1997-07-01

27

Onset of nucleate boiling and onset of fully developed subcooled boiling using pressure transducers signals spectral analysis

The experimental technique used for detection of subcooled boiling through analysis of the fluctuation contained in pressure transducer signals is presented. This work was partly conducted at the Institut fuer Kerntechnik und zertoerungsfreie Pruefverfahren von Hannover (IKPH, Germany) in a thermal-hydraulic circuit with one electrically heated rod with annular geometry test section. Piezo resistive pressure sensors are used for onset of nucleate boiling (ONB) and onset of fully developed boiling (OFDB) detection using spectral analysis/ signal correlation techniques. Experimental results are interpreted by phenomenological analysis of these two points and compared with existing correlation. The results allow to conclude that this technique is adequate for the detection and monitoring of the ONB and OFDB. (author)

28

Experimental compliance calibration for the mixed-mode bending (MMB) specimen

The experimental technique used for detection of subcooled boiling through analysis of the fluctuation contained in pressure transducer signals is presented. This work was partly conducted at the Institut fuer Kerntechnik und zertoerungsfreie Pruefverfahren von Hannover (IKPH, Germany) in a thermal-hydraulic circuit with one electrically heated rod with annular geometry test section. Piezo resistive pressure sensors are used for onset of nucleate boiling (ONB) and onset of fully developed boiling (OFDB) detection using spectral analysis/ signal correlation techniques. Experimental results are interpreted by phenomenological analysis of these two points and compared with existing correlation. The results allow to conclude that this technique is adequate for the detection and monitoring of the ONB and OFDB. (author)

2001-12-01

29

Stabilization of synchrotron radiation x-ray beam by MOSTAB

A novel method to control the mixed-mode bending (MMB) specimen is presented. By maintaining a constant opening, or Mode 1, displacement rate, stable delamination growth is achieved for all mixed-mode ratios. A constant-opening displacement rate is achieved by attaching a second displacement transducer to the hinges of the specimen. The test machine is then controlled externally by the second displacement transducer. By achieving stable delamination growth and monitoring the opening displacement, an experimental compliance calibration may be derived for the Modes 1 and 2 parts. This new approach to control the test and determine the experimental compliance calibration, overcomes the potential inaccuracies of the previously used beam theory expressions to determine compliance and to separate the modal values of G.

1997-12-31

30

New Insights into Type II NAD(P)H:Quinone Oxidoreductases

Monochromator stabilization (MOSTAB) is a feedback control system to stabilize an x-ray beam of synchrotron radiation. It applies a feedback voltage to a piezo electric transducer attached to a double-crystal monochromator. We developed MOSTAB modules and examined their performances using SPring-8 beamlines. The x-ray beam position stabilization using MOSTAB was realized simultaneously with the x-ray beam intensity stabilization. As an example of its application, we performed EXAFS measurement with MOSTAB. (author)

2003-05-01

31

Measurement of audible noise from transmission lines

Type II NAD(P)H:quinone oxidoreductases (NDH-2) catalyze the two-electron transfer from NAD(P)H to quinones, without any energy-transducing site. NDH-2 accomplish the turnover of NAD(P)H, regenerating...Full Text Available

2004-12-01

32

Molecular portraits of human breast tumours

The audible noise produced by corona on high-voltage transmission lines has several characteristics that differentiate it from other community noises. Transmission line noise is quite broadband and has a significant high frequency content. Special instrumentation designed to measure this type of noise pollution is described. All measuring systems have the same three basic elements: a transducer, a processing device, and an output device. Recorders, microphone devices, frequency analyzers, and meteorological instrumentation are discussed.

1981-03-01

33

Glycosaminoglycan synthesis by human corneal explants

No abstract prepared.

2000-08-01

34

The Brazilian spherical detector: progress and plans

No abstract prepared.

1998-07-01

35

Performance characterization of a volumetric breast ultrasound scanner

We are building the Schenberg gravitational wave detector at the Physics Institute of University of Sao Paulo as programmed by the Brazilian Graviton Project. The antenna and its vibration isolation system are already built, and we have made a first cryogenic run for an overall test, in which we measured the antenna mechanical Q (figure of merit). We also have built a 10.21 GHz oscillator with phase noise performance better than -120 dBc at 3.2 kHz to pump an initial CuAl6% two-mode transducer. We plan to prepare this spherical antenna for a first operational run at 4.2 K with a single transducer and an initial target sensitivity of h #approx# 2 x 10"-"2"1 Hz"-"1"/"2 in a 50 Hz bandwidth around 3.2 kHz soon. Here we present details of this plan and some recent results of the development of this project.

2004-03-07

36

Improvement of detectability for circumferential crack of Steam Generator tube by eddy current and ultrasonic testing method

The purpose of this project was to design, build, and characterize the performance of a volume breast ultrasound (VBUS) scanner that images the pendant breast. VBUS scanner design includes a: 1) clinical ultrasound scanner and transducer; 2) scanning table with a hole for the pendant breast; 3) rotational gantry; 4) probe mounting assembly; 5) compressionless breast stabilization device; 6) acquisition, control, reconstruction, and display software. Performance assessment characterized a variety of parameters including: spatial resolution, uniformity, and distortion using high and low contrast test objects in both horizontal and vertical scanning modes. The VBUS scanner modules have been constructed and initial performance evaluated. Approximately 300 scans are acquired over 360 degrees in 18 seconds. Reconstruction requires 25 ms per slice. Test object images depicted hyper- and hypo-echoic masses and demonstrated good resolution, soft tissue contrast and reduced ...

2007-03-01

37

Fundamentals for remote structural health monitoring of wind turbine blades - a pre-project. Annex D - Full-scale test of wind turbine blade, using sensors and NDT

Steam Generator (SG) tubes in PWR plant are periodically inspected using eddy current testing (ECT) method. In Japan, bobbin coil type dual function probe is used for full length inspection, but the detectability for circumferential crack is very poor, and to improve detectability for circumferential crack and supplement regular ECT, various kinds of multi segment eddy current probes and multi transducer ultrasonic testing (UT) method have been developed. ECT probes are constructed of multiple surfaceriding special winding differential type coils and UT probe consists of 16 transducers which are spaced equally around the probe circumference for 360deg wall coverage. Both of those EC and UT probes are designed effective to detect circumferential crack. On the other hand, various kinds of laboratory induced circumferential cracks have been made and destroyed to prove the detectability of these probes. (author).

1991-08-01

38

Nutrition and Physical Activity in Aging, Obesity, and Cancer

A 19.1 metre wind turbine blade was subjected to static tests. The purpose of the test series was to verify the abilities of different types of sensors to detect damage in wind turbine blades. Prior to each of the static test-series an artificial damage was made on the blade. The damage made for each test-series was surveyed during each series by acoustic emission, fiber optic micro bend displacement transducers and strain gauges. The propagation of the damage was determined by use of ultra sonic and X-ray surveillance during stops in the test series. By use of acoustic emission it was possible to measure damage propagation before the propagation was of visible size. By use of fiber optic micro bend displacement transducers and strain gauges it was possible to measure minor damage propagation. By use of both ultra sonic, and X-ray NDT-equipment it were possible to determine the size of propagated damage. (au)

2002-05-01

39

British Library Electronic Table of Contents (United Kingdom)

The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH-STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH-STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH-STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.

2011-01-01

40

Methods and instruments for nondestructive testing of the anisotropy of the magnetic properties of ferromagnetic sheet materials (review)

Loaded Transducer Fpr Downhole Drilling Component

This review of methods and designs of transducers for nondestructive determination of the magnitude and nature of the anisotropy of magnetic properties (permeability, induction, coercive force, energy loss due to magnetization reversal) in local portions of ferromagnetic sheet and, in some cases, in individual parts of products. The need to measure the anisotropy is considered for two angles: for the case when the anisotropy is due to the crystallographic texture and determines the main operating characteristics of widely used sheet such as electrical steel and automobile body sheet, and for crystallographically isotropic materials, in which the anisotropy of magnetic properties as a result of mechanical stresses is a measure for determining the internal stresses.

1995-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

41

Acoustic wave device using plate modes with surface-parallel displacement

A robust transmission element for transmitting information between downhole tools, such as sections of drill pipe, in the presence of hostile environmental conditions, such as heat, dirt, rocks, mud, fluids, lubricants, and the like. The transmission element maintains reliable connectivity between transmission elements, thereby providing an uninterrupted flow of information between drill string components. A transmission element is mounted within a recess proximate a mating surface of a downhole drilling component, such as a section of drill pipe. To close gaps present between transmission elements, transmission elements may be biased with a "spring force," urging them closer together.

2005-07-05

42

Synthetic Biology and Human Health: Potential Applications for Spaceflight

Solid-state acoustic sensors for monitoring conditions at a surface immersed in a liquid and for monitoring concentrations of species in a liquid and for monitoring electrical properties of a liquid are formed by placing interdigital input and output transducers on a piezoelectric substrate and propagating acoustic plate modes therebetween. The deposition or removal of material on or from, respectively, a thin film in contact with the surface, or changes in the mechanical properties of a thin film in contact with the surface, or changes in the electrical characteristics of the solution, create perturbations in the velocity and attenuation of the acoustic plate modes as a function of these properties or changes in them.

1992-01-01

43

Immunohistochemical expression of p63 in human prenatal tooth primordia

Human space travelers experience a unique environment that affects homeostasis and physiologic

2011-01-01

44

Human Waste Handling-Kooyman

development, histochemical, human, malformation, p63 gene, tooth

2005-01-01

45

3 CFR - Guidelines for Human Stem Cell Research

... wood, kitchen wastes, and human faeces with the ash from such burning deposited and retained in an ...

46

Human endogenous retroviruses: transposable elements with potential ?

...false Guidelines for Human Stem Cell Research Presidential Documents ...2009 Guidelines for Human Stem Cell Research Memorandum for the Heads...scientifically worthy human stem cell research, including human...

2010-01-01

47

Human Factors in Network Security

Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitute part of the human genome. These viruses, perhaps representative of previous exogenous...Full Text Available

2004-10-01

48

Zoonoses-With Friends Like This, Who Needs Enemies?

... TITLE (Indlude Security Classifkcation) Human Factors in Network Security 12. ... FIELD GROUP SUBGROUP Human Factors, Network, Security 19. ...

1991-03-21

49

The big picture reflections on science, humanity, and a quickly changing planet

Zoonoses are infections that are spread from animals to humans. Most often, humans are “dead-end” hosts, meaning that there is no subsequent human-to-human transmission. If one considers...Full Text Available

2008-01-01

50

CERN Document Server

The big picture

2009-01-01

51

Molecular and immunological comparison of human dihydropteridine reductase in liver, cultured fibroblasts and continuous lymphoid cells.

Military workingn> dogs may be a sentinel for human cancer.

An antiserum was raised in a rabbit against highly purified human liver dihydropteridine reductase (EC 1.6.99.7). Dihydropteridine reductase from human liver, in human cultured fibroblasts and in continuous...Full Text Available

1981-07-01

52

Humanities for medical students? A qualitative study of a medical humanities curriculum in a medical school program

PMID:2348465

1990-06-20

53

Epigenetic changes accompanying human mammary epithelial cell Immortalization

BackgroundToday, there is a trend towards establishing the medical humanities as a component of medical education. However, medical humanities programs that exist within the context...Full Text Available

54

Effect of Electromagnetic Fields on Growth of Human Cell Lines

No abstract prepared.

2000-10-03

55

Theoretical and basic experimental analysis on load adjustment of geothermal heat pump systems

Full Text Available

2001-10-01

56

Pineal and photoperiodic influences on fat deposition, pelage, and testicular activity in male meadow voles.

In order to match the output capacity of a geothermal heat pump system (GHPS) with the actual load requirement, research has been conducted in searching for suitable adjusting methods for the GHPS and on the subsequent effects on the working parameters of the GHPS. Firstly, several methods are compared, and it is found that the method of adjusting the compressor's rotation speed using a transducer is better than the others. Secondly, this method is experimented on a small scale GHPS at frequencies ranging from 30 to 55 Hz. The analysis of the experimental data reveals the relationships between the compressor frequency and other important parameters, such as coefficient of performance, heat capacity, cool capacity and compressor power input. The conclusions in the paper can serve as some guidance to the load adjustment of GHPS. (Author)

2003-01-01

57

High speed inverted optical-resolution photoacoustic microscopy

Pinealectomy completely prevented gonadal regression as well as reduction in body weight and white adipose tissue content of the gonadal and retroperitoneal fat deposits in male meadow voles transferred from long to short day lengths. Pineal influences on pelage characteristics depended on which parameter was assessed. For instance, the increase in guard hair length observed in short-day control voles was blocked by pinealectomy; however, a similar increase in underhair length was unaffected by removal of the pineal gland. Photoperiod-dependent changes in fat deposition, testicular activity, and guard hair length presumably rely on altered pineal secretory activity to transduce the effects of day length on the neuroendocrine axis; however, mechanisms independent of pineal activity may be capable of mediating photoperiodic control of underhair growth. PMID:2979644

1988-01-01

58

Flow-induced changes in pial artery compliance registered with a non-invasive method in rabbits

Photoacoustic microscopy (PAM) offers label-free, optical absorption contrast. A high-speed, high-resolution PAM system in an inverted microscope configuration with a laser pulse repetition rate of 100,000 Hz and a stationary ultrasonic transducer was built. Four-dimensional in vivo imaging of microcirculation in mouse skin was achieved at 18 three-dimensional volumes per second with repeated two-dimensional raster scans of 100 by 50 points. The corresponding twodimensional B-scan (50 A-lines) frame rate was 1800 Hz, and the one-dimensional A-scan rate was 90,000 Hz. The lateral resolution is 0.23+/-0.03 ?m for Au nano-wire imaging, which is 2.0 times below the diffraction limit.

2011-02-01

59

British Library Electronic Table of Contents (United Kingdom)

Aim: This study was performed: 1) to assess the relationship between blood flow velocity in the internal carotid artery (CBFICA) and pial artery pulsation (cc-TQ) and 2) to evaluate flow-induced changes in pial artery compliance. Methods: Experiments were performed on 10 crossbred male rabbits. Heart rate (HR), blood pressure (BP), left ventricle ejection fraction (LVEF), CBFICA, the systolic-diastolic blood volume fraction in the brain circulation (CBFSDF) and cc-TQ were recorded after glucagon and acetazolamide administration. cc-TQ was measured with near-infrared transillumination back scattering sounding (NIR-T/BSS), LVEF and CBFSDF with gated scintigraphy and BP and CBFICA with electromagnetic pressure and flow transducers, respectively. Doses of drugs were chosen to exert a haemodyna...

2011-01-01

60

Field results using measurement-while-drilling directional systems in Long Beach, California

Experimental modelling of thermal consolidation effects around a high level waste repository

One of the more extensive uses of directional drilling anywhere in the world has been in the development of the East Wilmington Oil Field in Long Beach, California. The Measurement-While-Drilling (MWD) directional system has been tested on several wells and proven to provide the required accuracy, along with many advantages over past methods, used in the field development. Accurate transmission by MWD of bottom-hole measurements to the surface is provided by mud pressure pulses generated in the drill pipe downhole and detected by a pressure transducer includes the means for detecting, recording and processing these pressure pulses, to translate the information from the pressure pulses to rig floor displays usable by the drilling crew. 2 refs.

1981-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

61

Evaluation of Capiox FX05 Oxygenator With an Integrated Arterial Filter on Trapping Gaseous Microemboli and Pressure Drop With Open and Closed Purge Line

This report summarizes the results of a research programme which involves the development of a laboratory experimental facility for the simulation and study of hydro-thermo-mechanical processes in saturated geomaterials with low permeability. The experimentation involves a synthetic cement based porous material made of cement grout which possesses permeabilities in the range of dense unfractured sandstones or shale. Specially manufactured pore-pressure transducers were installed within the cylindrical block at locations adjacent to a plane free boundary. The block was saturated with the periodic application of a vacuum. In its saturated state the plane boundary of the block was subjected to heating via a circular heater the temperature of which was maintained constant. The resulting pore pressure generation along with temperature at these locations was monitored continuously. The results of a series of experiments are documented and further extensions to the ...

62

British Library Electronic Table of Contents (United Kingdom)

Abstract Gaseous microemboli (GME) remain a challenge for cardiopulmonary bypass (CPB) because there is a positive correlation between microemboli exposure during CPB and postoperative neurological injury. Thus, minimizing the number of GME delivered to pediatric patients undergoing CPB procedures would lead to better clinical outcomes. In this study, we used a simulated CPB model to evaluate the effectiveness of capturing GME and the degree of membrane pressure drop for a new membrane oxygenator, Capiox Baby FX05 (Terumo Corporation, Tokyo, Japan), which has an integrated arterial filter with open and closed purge line. We used identical components in this study as our clinical CPB circuit. Three emboli detection and classification quantifier transducers were placed at prepump, preoxygena...

2010-01-01

63

Dynamically focussed array

Chemical sensors based on surface-confined dendrimers

An array of sonic transducers, useful for medical ultrasonic imaging, has individual sections thereof separately coupled for forming separate beams of sonic energy which converge, respectively, to separate foci along a common axis of the beams. The ratio of the diameter of the radiating aperture of the array relative to a wavelength of the sonic energy is chosen to provide a moderate degree of focusing so that the depth of field at one focus blends with the depth of field of the next focus. Thereby, there is formed a continuous region of substantially uniform intensity of sonic radiation along the common beam axis. Circuitry is provided for selecting one or more specific foci dependent on the bounds of a selected region to be insonified. Upon reception of sonic energy, circuitry is provided for selecting one or more specific foci as a function of the time of travel of an echo from a subject being observed to approximate a continuously varying focus in accordance ...

1981-07-07

64

Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats

The use of dendrimers for preparing chemically sensitive interfaces for detecting volatile organic compounds (VOCs) using surface acoustic wave (SAW) device transducers is described. Specifically, the synthesis of the dendrimers and the means by which they are affixed to SAW devices is discussed, followed by a detailed spectroscopic analysis of the surface-confined dendrimers and a discussion of their interaction with different VOCs. Most of these preliminary experiments focus on dendrimer surface modification using benzoylchloride, which leads to phenyl terminal groups linked to the dendrimer via amide groups. The results of this study lead us to conclude that dendrimers: (1) provide general specificity towards classes of functional groups and are therefore suitable for array-based sensing schemes; (2) are intermediate in structure between monolayers and polymers and exhibit the desirable properties of both; (3) can be straightforwardly attached to the surfaces of ...

1997-10-01

65

British Library Electronic Table of Contents (United Kingdom)

To test the hypothesis that transduction of the channelrhodopsin-2 (ChR2) gene, a microbial-type rhodopsin gene, into retinal ganglion cells of genetically blind rats will restore functional vision, we recorded visually evoked potentials and tested the experimental rats for the presence of optomotor responses. The N-terminal fragment of the ChR2 gene was fused to the fluorescent protein Venus and inserted into an adeno-associated virus to make AAV2-ChR2V. AAV2-ChR2V was injected intravitreally into the eyes of 6-month-old dystrophic RCS (rdy/rdy) rats. Visual function was evaluated six weeks after the injection by recording visually evoked potentials (VEPs) and testing optomotor responses. The expression of ChR2V in the retina was investigated histologically. We found that VEPs could not b...

2010-01-01

66

Ceramic Materials and Devices

Cavity ringdown spectroscopy with a continuous-wave laser: calculation of coupling efficiency and a new spectrometer design.

Course website from Cambridge on ceramic materials. This site contains eight lectures in PDF format (Adobe Reader required), two question sheets, five practicals (including answers), digital movies and further useful links. "There is a strong relationship between the structure of a material and its physical properties. The properties of a material whether mechanical, electrical, optical or magnetic, determine how it can be used in practical applications. In this course, the focus is on the structure / property relationship for ionic materials with electrical properties utilised in various transducer devices. The materials considered include perovskites, which have special polarisation properties exploited in ferroelectric, pyroelectric and piezoelectric devices. Other oxides, such as zirconia, have structures permitting rapid diffusion of ions, making them suitable for use in sensors, fuel cells and batteries. The scientific principles underlying the properties of ...

2007-02-01

67

Better machinery monitoring

For the efficient operation of a cavity ringdown spectroscopy (CRDS) system utilized with a continuous-wave (cw) laser, we numerically analyze the coupling efficiency of a cw laser to a ringdown cavity in terms of changes in the scanning rate, the laser linewidth, and the mirror reflectivity. We also demonstrate a new simple design for a CRDS system that can produce a CRDS signal with only a piezoelectric transducer (PZT), without the acousto-optic modulator that is usually adopted to switch off the cw laser beam that enters the cavity. Furthermore, we investigate the feasibility of the cw CRDS technique with a fast-scanning PZT by recording a CRDS spectrum of acetylene overtones. The detection sensitivity that corresponds to the noise-equivalent absorption is found to be approximately 3 x 10(-9)/cm. PMID:18305817

1999-03-20

68

Targeting Prostate Cancer Cells In Vivo Using a Rapidly Internalizing Novel Human Single-Chain Antibody Fragment

This paper discusses how specialized techniques for machine condition monitoring can help to eliminate false alarms and undetected faults, leading to a truly cost effective predictive maintenance program. It is vital to base the monitoring system on the parameter which will give the most useful information about potential faults and breakdowns. This parameter is generally agreed to be vibration. While oil debris analysis and variations in temperature, geometry and machine speed can all give advance warning of faults, no other parameter can reveal as wide a range of fault types as vibration. The vibration transducers job is to accurately and faithfully convert the vibration into an electric signal for assessment. If this part of the system is weak, reliability will be badly affected. Data integrity is crucial.

1990-07-01

69

Suppression by IgA of IgG-mediated phagocytosis by human polymorphonuclear leucocytes

Human antibodies targeting prostate cancer cell surface epitopes may be useful for imaging and therapy. The objective of this study was to evaluate the tumor targeting of an internalizing human...Full Text Available

2010-03-01

70

Rhythmic Dynamics and Synchronization via Dimensionality Reduction: Application to Human Gait

IgA from normal human serum, a myeloma IgA and human colostral IgA were found to inhibit the IgG-dependent phagocytosis of Candida albicans (CA) blastospores by polymorphonuclear leucocytes...Full Text Available

1978-12-01

71

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411

Reliable characterization of locomotor dynamics of human walking is vital to understanding the neuromuscular control of human locomotion and disease diagnosis. However, the inherent oscillation and...Full Text Available

2010-12-01

72

Human variability and susceptibility to trichloroethylene.

Our goal was to determine whether chlorpyrifos oxon, dichlorvos, diisopropylfluorophosphate (DFP), and sarin covalently bind to human albumin. Human albumin or plasma was treated with organophosphorus...Full Text Available

2007-02-15

73

Human placental transport of cimetidine.

Although humans vary in their response to chemicals, comprehensive measures of susceptibility have generally not been incorporated into human risk assessment. The U.S. EPA dose-response-based risk assessments...Full Text Available

2000-05-01

74

Genome-wide detection and characterization of positive selection in human populations

This study addresses the mechanism of transport of the H2-receptor antagonist, cimetidine, by the human placenta. A 4-h recycling perfusion of a single placental cotyledon of normal, term, human placenta...Full Text Available

1987-11-01

75

Establishment of an Immunoglobulin M Antibody-Forming Cell Response Model for Characterizing Immunotoxicity in Primary Human B Cells

With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms...Full Text Available

2007-10-18

76

Drug-binding properties of human alpha-foetoprotein.

Rodent models have been extensively utilized to identify putative human immunotoxicants; however, even when immunotoxicity is established, uncertainty remains whether the effects are predictive of human...Full Text Available

2009-12-01

77

A haplotype map of the human genome

The drug-binding properties of human alpha-foetoprotein (alpha FP) were investigated by a fluorescence-spectral method. Human alpha FP was shown to bind to albumin's site I marker (warfarin, phenylbutazone),...Full Text Available

1985-10-01

78

Uptake and Retention of Adenine Moiety by Stored Human ...

Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million...Full Text Available

2005-10-27

79

The inhibition of the primary interaction between "1"2"5I-labeled human hemoglobin and rabbit anti-human hemoglobin sera: a sensitive radioimmunoassay technique

... Accession Number : AD0749455. Title : Uptake and Retention of Adenine Moiety by Stored Human Red Blood Cells. Descriptive Note : Interim rept.,. ...

1972-06-30

80

Structure design of human factor data management system for Daya Bay NPP

... ammonium compounds antigen-antibody reactions hemoglobin inhibition

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

81

Quantifying Risk Factors for Human Brucellosis in Rural Northern Tanzania

Collection, analysis and quantification of human factor data are important compositions of human reliability analysis (HRA) and probabilistic risk assessment (PRA). Various human factor databases have been set up, but there are comparatively little human factor data management systems which can be uses for collection, classification, analysis, calculation and predication of the human factor data. Therefore, the human factor data management system for Daya Bay NPP is developed, with the following three modules and four databases: original data module, computing module, introduced data module, and basic database, other data source of the plant, external database and introduced database. The foundational problems about human factor data and the systemic structure and function are described. The data structure in the database is also discussed, ...

2000-04-01

82

Priorities for human nutrition research using stable isotopes in India

BackgroundBrucellosis is a zoonosis of veterinary, public health and economic significance in most developing countries. Human brucellosis is a severely debilitating disease that...Full Text Available

83

Navy Requirements for Controlling Multiple Off-Board Robots ...

In this paper, an attempt is made to outline the priority areas for research in human nutrition in India that could be tackled by appropriate application of stable isotope technology. 10 refs.

1989-06-06

84

Measurement methods for human exposure analysis.

... less humans have to do to operate a robot. ... Robots can help human operators with the increase ... important mission outlined by the UUV master plan. ...

2007-06-01

85

Imaging oxygenation of human tumours

The general methods used to complete measurements of human exposures are identified and illustrations are provided for the cases of indirect and direct methods used for exposure analysis. The application...Full Text Available

1995-04-01

86

Human-modified ecosystems and future evolution

Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive and...Full Text Available

2007-04-01

87

Our global impact is finally receiving the scientific attention it deserves. The outcome will largely determine the future course of evolution. Human-modified ecosystems are shaped by our activities...Full Text Available

2001-05-08

88

Human factors

Do Perfluoroalkyl Compounds Impair Human Semen Quality?

This is a presentation on Human Factors in reactor operations. It discusses issues that deal with power plant operations, training and design, operational effectiveness and safety, supporting people to achieve effective and error free performance.

2002-07-01

89

A Transposon and Transposase System for Human Application

BackgroundPerfluoroalkyl acids (PFAAs) are found globally in wildlife and humans and are suspected to act as endocrine disruptors. There are no previous reports of PFAA levels in...Full Text Available

2009-06-01

90

A Four-Dimensional Probabilistic Atlas of the Human Brain

The stable introduction of therapeutic transgenes into human cells can be accomplished using viral and nonviral approaches. Transduction with clinical-grade recombinant viruses offers the potential...Full Text Available

2010-04-01

91

A Detailed Investigation on Human-Related Unplanned Reactor Trip Events in Korea

The authors describe the development of a four-dimensional atlas and reference system that includes both macroscopic and microscopic information on structure and function of the human brain in persons...Full Text Available

2001-09-01

92

A Comparison of Some Demand Subject Searches: Machine vs. Human

Human errors have been reported as one of the most significant causes of major events in nuclear power plants (NPPs). For example, Kim and Park found that about 23% of the major events that occurred at NPPs in Republic of Korea from 1986 to 2006 were caused by human errors. For this reason, a detailed analysis on human errors is an important task for increasing the safety of NPPs. Kim and Choi?2 analyzed 100 human-related unplanned reactor trip events in the Republic of Korea from 1986 to 2006 to consider the type of human errors based on the simple path model for human-induced unplanned reactor trips developed by Kim and Park. In this paper, we will investigate and perform a detailed analysis of the data to identify human-related unplanned reactor trip trends

2010-10-01

93

Time-of-Flight Measurements from Eddy Current Tests

A comparison of the results of machine and human information retrieval using MEDLARS and the printed Index Medicus indicates that at present neither method is entirely satisfactory...Full Text Available

1967-10-01

94

The neuroimmune-endocrine axis: pathophysiological implications for the central nervous system cytokines and hypothalamus-pituitary-adrenal hormone dynamics

Data fusion techniques are based on the premise that two or more carefully designed NDE tests are potentially capable of offering additional information concerning the test object relative to what can be garnered from a single test. However, information from a heterogeneous set of transducers cannot be fused unless the data is mapped onto a common `format'. The eddy current method cannot, for example, provide time-of-flight information that can be combined from estimates derived from ultrasonic tests. This paper presents a simple solution to address the problem by employing the so-called Q-transform to relate diffusive fields, such as those generated by eddy current probes, and propagating wave fields generated by ultrasonic NDT sensors. The paper illustrates how the distance between a defect and a source can be extracted from eddy current data generated using carefully selected excitation signals. Numerical results and comparisons with analytical predictions are ...

2003-03-01

95

Scientific Electronic Library Online (English)

Abstract in english Cytokines are molecules that were initially discovered in the immune system as mediators of communication between various types of immune cells. However, it soon became evident that cytokines exert profound effects on key functions of the central nervous system, such as food intake, fever, neuroendocrine regulation, long-term potentiation, and behavior. In the 80's and 90's our group and others discovered that the genes encoding various cytokines and their receptors are e (more) xpressed in vascular, glial, and neuronal structures of the adult brain. Most cytokines act through cell surface receptors that have one transmembrane domain and which transduce a signal through the JAK/STAT pathway. Of particular physiological and pathophysiological relevance is the fact that cytokines are potent regulators of hypothalamic neuropeptidergic systems that maintain neuroendocrine homeostasis and which regulate the body's response to stress. The mechanisms ...

2000-10-01

96

The influence of electromagnetic field irradiated by high-voltage transmission lines on properties of cells.

Review of progress in quantitative NDE. Abstracts

The influence of low-frequency electromagnetic field irradiating by high-voltage transmission lines on signal transduction of cell in spleen cells of the rates have been studied by molecular-biology techniques. The spleen cells are extracted from skilled rates, which are exposed in the electromagnetic field of high-voltage transmission lines with 4000 V/m and 0.09-0.1 G about 400 days. The quantity or level of phosphorylation of signal transducer and activator of transcription (STAT3) in JAK-STAT signal transduction pathway of spleen cells, which are stimulated and unstimulated by IL-2, respectively, are detected by the immunoblotting and immunobiochemistry. The results show that the expression of phospho-STAT3 in spleen cell stimulated by IL-2 differ not from that in the unstimulated cell. The former is significantly large than the latter. This shows that signal transduction of cell is affected by this electromagnetic field. The spectra of infrared absorption for ...

2005-01-01

97

Retrieval of intravascular foreign bodies with goose neck snare

The meeting was arranged into the following sessions: introductory; advanced ceramics and ceramic composites; ceramic and metal matrix composites; electronic materials and devices; acoustoelasticity, stress, and texture; composites-porosity, strength, and UT propagation; process modeling and monitoring; thermal wave physics; material properties, composites, surfaces, and interfaces; acoustic emission; ferromagnetic materials; new sensors; NDE reliability assessment; elastic wave scattering and propagation; image analysis, data storage, and signal processing; UT transducers; weldments and bonded materials; eddy current models; unified life cycle engineering; x rays, CT, and NMR; eddy current probes and instruments; acoustic microscopy imaging, and reconstruction; signal processing, measurement techniques, and systems; NDE applications of artificial intelligence; crack behavior influenced by history; inversion procedures for UT and EC; process control and material ...

1986-01-01

98

Propagation of guided waves in aircraft structure

Purpose: to evaluate the efficacy and advantages of the snare systems in the retrieval of foreign bodies from vascular system. Materials and methods: the snare technique has been used for intravascular foreign body retrieval. We performed percutaneous extraction of intravascular foreign bodies using combination multipurpose catheters and a nitinol snare loop. In this report, we evaluated the patients who had performed endovascular device reposition or foreign body retrieval from 1998 to 2001. Results: foreign body retrieval was performed in 15 patients. The foreign bodies consisted of seven fractured port catheters, one sheath fragment, one embolization coil, four wire fragments, one pace-maker transducer and one dislocated endovascular stent. In no case were surgical procedures required, and no complications were encountered. Conclusion: the snare technique is a useful and a safe method as an alternative procedure to surgery. This technique is highly effective ...

2004-03-01

99

Pressure Fluctuations as a Diagnostic Tool for Fluidized Beds

The potential of ultrasonic guided modes for use in global structural health monitoring of aging metallic aircraft can only be realized if the modes selected are able to propagate over a reasonable distance. This work studies the propagation of different modes through fuselage structure by means of mode analysis, finite element modeling and experimental measurement. Beginning with the case of a simple skin panel, the paper examines propagation across a set of structural features representing a typical monocoque fuselage and considers the effect of overlying sealant layers, bonded and sealed joints, paint layers and tapering skin. With the exception of the fundamental symmetric mode at very low frequency, no mode was found that could propagate across all features with an effective attenuation of less than 40 dB/m. This makes global monitoring of a fuselage structure using a sparse array of transducers very difficult. However, more local monitoring is possible and ...

2000-05-23

100

NADP Regulates the Yeast GAL Induction System

The purpose of this project was to investigate the origin of pressure fluctuations in fluidized bed systems. The study assessed the potential for using pressure fluctuations as an indicator of fluidized bed hydrodynamics in both laboratory scale cold-models and industrial scale boilers. Both bubbling fluidized beds and circulating fluidized beds were evaluated. Testing including both cold-flow models and laboratory and industrial-scale combustors operating at elevated temperatures. The study yielded several conclusions on the relationship of pressure fluctuations and hydrodynamic behavior in fluidized beds. The study revealed the importance of collecting sufficiently long data sets to capture low frequency (on the order of 1 Hz) pressure phenomena in fluidized beds. Past research has tended toward truncated data sets collected with high frequency response transducers, which miss much of the spectral structure of fluidized bed hydrodynamics. As a result, many ...

1998-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

101

MR imaging of experimental intramuscular hemorrhage at 0. 02 T; Contrast enhancement with Gd-DOTA

Transcriptional regulation of the galactose-metabolizing genes in Saccharomyces cerevisiae depends on three core proteins: Gal4p, the transcriptional activator that binds to upstream activating DNA sequences (UASGAL); Gal80p, a repressor that binds to the carboxyl terminus of Gal4p and inhibits transcription; and Gal3p, a cytoplasmic transducer that, upon binding galactose and adenosine 5'-triphosphate, relieves Gal80p repression. The current model of induction relies on Gal3p sequestering Gal80p in the cytoplasm. However, the rapid induction of this system implies that there is a missing factor. Our structure of Gal80p in complex with a peptide from the carboxyl-terminal activation domain of Gal4p reveals the existence of a dinucleotide that mediates the interaction between the two. Biochemical and in vivo experiments suggests that nicotinamide adenine dinucleotide phosphate (NADP) plays a key role in the initial induction event.

2008-01-01

102

Limitations of traveling wave relaying for overhead EHV transmission lines

Intramuscular hermorrhage was induced by injecting autologous blood into the paraspinal muscle of 8 rabbits. In order to evaluate the time-dependent changes of hemorrhage observed on MRI, the animals were imaged at different stages of blood resolution at 0.02 tesla (T), and control examined with ultrasound using a 7.5 MHz linear transducer. Six inversion recovery sequences (TR=1 000 ms. TE=30 ms, and TI=18, 48, 148, 201, 302, and 398 ms) were used for the invivo calculation of T1 relaxation times. IR 1 000 (398)/30 imaging was performed before and after the Gd-DOTA administration. The hemorrhage was evident on MR images throughout the study, especially on the T2 weighted (SE 1 000/100) images. MRI showed the healing lesion longer than ultrasound. The T1 relaxation time increased during the time of resolution. Lesions on days 4 to 7 enhanced in intensity after the injection of Gd-DOTA. (orig.).

1990-09-01

103

Effect of dissolved oxygen, hydrazine and pH outside the crevice on the galvanic corrosion of support plate alloys

Limitations of traveling wave relaying schemes for protection of overhead extra-high voltage transmission lines are investigated. A method of analysis of traveling wave phenomena for three phase transmission lines is developed in which the interdependent phase voltages and currents are decoupled into their modal counterparts, which are approximately independent. A time domain digital simulation program is used to solve the modal transmission line equations to obtain the fault induced traveling waves detected at the relay location. The frequency dependence of the aerial modes is ignored but their losses are included. A lumped element analysis method, originally developed for transient analysis of lossy coaxial cables, is adapted here to obtain approximate solution for the fault induced traveling waves of the ground mode. Excellent agreement is found between the results obtained by this method and frequency domain methods. This time-domain method offers more flexibility than frequency ...

1986-01-01

104

The human melanocyte: A model system to study the complexity of cellular aging and transformation in non-fibroblastic cells

A study has been performed of the initial corrosion of support structure alloys in crevices of various geometries, when galvanically coupled to alloy 600. Corrosion rates were monitored continuously by measuring the galvanic current flowing in each couple, transduced by a zero impedance ammeter. Experiments were performed in a single-pass flowing electrolyte system, with AVT water pumped through alloy 600 tubing past the orifice of each crevice. Fourteen crevices were studied simultaneously in two parallel flow arms containing seven specimens each. The steady state AVT water pH/hydrazine/oxygen concentrations were controlled by microcomputer, allowing the effect of secondary water chemistry on the corrosion rate to be studied easily. Control of the crevice electrolyte composition was achieved by separately pumping electrolyte, at a low rate, directly into the crevices of the seven specimens in the lower flow arm. In addition, a high pressure syringe was used to ...

1985-03-01

105

Statistical cut-off criterion

No abstract prepared.

2002-05-23

106

Simultaneous Measurement of Phagosome and Plasma Membrane Potentials in Human Neutrophils By Di-8-Anepps and SEER

... radiation effects human populations low dose irradiation neoplasms radiation

1980-01-01

107

Protective Effect of Some Medicinal Plants on tert-Butyl Hydroperoxide-Induced Oxidative Stress in Human Keratinocytes

Not Available

2010-01-01

108

Potential Increases in Mortality due to Global Warming

Full Text Available

2008-12-01

109

On-site burning, remote camp

... predicting potential increases in human mortality due to global warming....

110

Mechanistic aspects of fracture and R-curve behavior in human cortical bone

... wood, kitchen wastes, and human faeces. The ash from such waste burning shall be deposited and ...

111

Human anti-rhesus D IgG1 antibody produced in transgenic plants.

No abstract prepared.

2005-06-24

112

Human Issues in Manufacturing Technology

Udgivelsesdato: 2002-Apr

2002-01-01

113

Fiber optic infrared thermometer for accurate measurement of the core temperature of the human body

... qualified manufacturing employees. David Lichtinger, plant manager for Lord Corporation's aerospace products plant in ...

1992-09-01

114

Construction of the Transgenic Drosophila melanogaster Expressing a Human Megsin Gene.

Not Available

2001-06-01

115

Comparison between DNA damage investigated by the ''Comet'' assay and chromosomal damage induced in human lymphocytes by radiation and chemicals

Full Text Available

2007-05-01

116

Commentary on: Molecular basis for discriminating between normaland damaged bases by the human alkyladenine glycosylase, AAG

Short communication.

1995-08-20

117

CLINICOBACTERIOLOGICAL AND EPIDEMIOLOGICAL ...

No abstract prepared.

2001-03-05

118

Breath Test for Chemicals (Volatile Organic Compounds)

... Salmonella. Vdgella and Brucela also to the diagnosis of the septic- tylphoidal and enteric form of human peendotuber- auloals. ...

1963-11-01

119

Aspects of in vitro fatigue in human cortical bone: Time and cycle dependent crack growth

Breath Tests; Human Volunteers; Pilot Study

2011-09-16

120

Antiproliferation Effects of Germinated-Korean Rough Rice Extract on Human Cancer Cells

No abstract prepared.

2005-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

121

Analysis of the relationship between metabolic parameters and the low doses irradiation and non-raditaion factors in humans

Full Text Available

2010-03-01

122

A playmate robot system for playing the rock-paper-scissors game with humans

Short communication.

1994-10-25

123

Wastenet

com/Descartes-Error-Emotion-Reason-Human/dp/014303622X/ref=cm_lmf_img_12_rdssss0\\

124

British Library Electronic Table of Contents (United Kingdom)

We have developed a playmate robot system for playing the rock-paper-scissors game with humans. The playmate robot recognizes the hand motions of a human using image processing without attaching any additional units to the human. The playmate robot system consists of three parts: a game management part, a hand motion recognition part, and a robot hand control part. The system functions as follows. (1) Before the game is played, the game management part decides on the motion of the robot hand from amongst rock, paper, and scissors. After the game is played, the robot develops a reaction using speech and facial expressions depending on the result of the game. (2) The hand motion recognition part recognizes the hand motion of the human. It does not use any additional units on the human?s body...

2011-01-01

125

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

MEG studies of human vision: Retinotopic organization of V1

Two overlapping cDNA clones encoding human DNA topoisomerase II were identified by two independent methods. In one, a human cDNA library in phage {lambda} was screened by hybridization with a mixed oligonucleotide probe encoding a stretch of seven amino acids found in yeast and Drosophila DNA topoisomerase II; in the other, a different human cDNA library in a {lambda}gt11 expression vector was screened for the expression of antigenic determinants that are recognized by rabbit antibodies specific to human DNA topoisomerase II. The entire coding sequences of the human DNA topoisomerase II gene were determined from these and several additional clones, identified through the use of the cloned human TOP2 gene sequences as probes. Hybridization between the cloned sequences and mRNA and genomic DNA indicates that the human enzyme is encoded by a ...

1988-10-01

126

Improving the PSA quality in the human reliability analysis of pre-accident human errors

A primary goal of noninvasive studies of human vision is to identify and characterize multiple visual areas in the human brain analogous to those identified in studies of nonhuman primates. By combining functional MEG measurements with images of individual anatomy derived from MRI, the authors hope to determine the location and arrangement of multiple visual areas in human cortex and to probe their functional significance. The authors have identified several different visual areas thus far which appear to be topographically organized. This paper focuses on the retinotopic characterization of the primary visual area (V1) in humans.

1993-12-31

127

Improving the PSA quality in the human reliability analysis of pre-accident human errors

This paper describes the activities for improving the Probabilistic Safety Assessment (PSA) quality in the human reliability analysis (HRA) of the pre-accident human errors for the Korea Standard Nuclear Power Plant (KSNP). We evaluate the HRA results of the PSA for the KSNP and identify the items to be improved using the ASME PRA Standard. Evaluation results show that the ratio of items to be improved for pre-accident human errors is relatively high when compared with the ratio of those for post-accident human errors. They also show that more than 50% of the items to be improved for pre-accident human errors are related to the identification and screening analysis for them. In this paper, we develop the modeling guidelines for pre-accident human errors and apply them to the auxiliary feedwater system of the KSNP. Application results show that more than 50% of ...

2004-07-01

128

A Human Reliability Analysis of Post- Accident Human Errors in the Low Power and Shutdown PSA of KSNP

This paper describes the activities for improving the Probabilistic Safety Assessment (PSA) quality in the human reliability analysis (HRA) of the pre-accident human errors for the Korea Standard Nuclear Power Plant (KSNP). We evaluate the HRA results of the PSA for the KSNP and identify the items to be improved using the ASME PRA Standard. Evaluation results show that the ratio of items to be improved for pre-accident human errors is relatively high when compared with the ratio of those for post-accident human errors. They also show that more than 50% of the items to be improved for pre-accident human errors are related to the identification and screening analysis for them. In this paper, we develop the modeling guidelines for pre-accident human errors and apply them to the auxiliary feedwater system of the KSNP. Application results show that more than 50% of ...

2004-06-06

129

Social-ecological science in the humane metropolis

Korea Atomic Energy Research Institute, using the ANS low power and shutdown (LPSD) probabilistic risk assessment (PRA) Standard, evaluated the LPSD PSA model of the KSNP, Yonggwang Units 5 and 6, and identified the items to be improved. The evaluation results of human reliability analysis (HRA) of the post-accident human errors in the LPSD PSA model for the KSNP showed that 10 items among 19 items of supporting requirements for those in the ANS PRA Standard were identified as them to be improved. Thus, we newly carried out a HRA for post-accident human errors in the LPSD PSA model for the KSNP. Following tasks are the improvements in the HRA of post-accident human errors of the LPSD PSA model for the KSNP compared with the previous one: Interviews with operators in the interpretation of the procedure, modeling of operator actions, and the quantification results of human errors, ...

2010-05-01

130

British Library Electronic Table of Contents (United Kingdom)

The Humane metropolis is a rubric to summarize and promote environmental and social quality in contemporary urban mosaics. Because cities, suburbs, and exurbs, as spatially extensive and connected socio-ecological systems, exhibit many negative features, the humane metropolis identifies a strategy to combat the ills and instill more positive and sustainable features and processes in urban systems. Because the humane metropolis as a program has arisen primarily from social motivations, there is the opportunity to articulate more explicitly the role that science can play in addressing the humane metropolis program and evaluating its success. A humane metropolis can be summarized as one that 1) protects and restores ecological services in cities and suburbs, 2) promotes physical and mental he...

2011-01-01

131

Report on {open_quotes}inspection of human subject research in intelligence and intelligence-related projects{close_quotes}

Human cDNA mapping using fluorescence in situ hybridization. Final progress report, April 1, 1994--July 31, 1997

Executive Order 12333, {open_quotes}United States Intelligence Activities,{close_quotes} (1) designates the Department`s intelligence element as a member of the Intelligence Community, and (2) states that no agency within the Intelligence community shall sponsor, contract for or conduct research on human subjects except in accordance with guidelines issued by the Department of Health and Human Services. The Federal policy for the Protection of Human Subjects, which was based on Department of Health and Human Services regulations, was promulgated in Title 10 Code of Federal Regulations Part 745 by the Department of Energy. The purpose of this inspection was to review the internal control procedures used by the Office of Nonproliferation and National Security to manage selected intelligence and intelligence-related projects that involve human subject research.

1996-01-16

132

Homologous radioimmunoassay for human prolactin

The ultimate goal of this research is to generate and apply novel technologies to speed completion and integration of the human genome map and sequence with biomedical problems. To do this, techniques were developed and genome-wide resources generated. This includes a genome-wide Mapped and Integrated BAC/PAC Resource that has been used for gene finding, map completion and anchoring, breakpoint definition and sequencing. In the last period of the grant, the Human Mapped BAC/PAC Resource was also applied to determine regions of human variation and to develop a novel paradigm of primate evolution through to humans. Further, in order to more rapidly evaluate animal models of human disease, a BAC Map of the mouse was generated in collaboration with the MTI Genome Center, Dr. Bruce Birren.

1997-12-31

133

Whole-genome shotgun assembly and comparison of human genome assemblies

Although thee are descriptions of a range of radioimmunoassays for human prolactin in various biological fluids, only one of these is an homologous assay using human prolactin as the reference standard and tracer as well and an anti-human prolactin antiserum (Sinha, Y.N., Selby, F.W.; Lewis, U.; and Vanderlaan, W.P., 1973, J. Clin. Endocr., Vol. 36, 509). A homologous radioimmunoassay using human putuitary prolactin has been developed. The separation method is based on the double antibody solid phase system. Cross reactivity with human growth hormone (GH), placental lactogen (HPL), the pituitary protein hormones and prolactins of various species were studied as were values found in normal subjects in basal conditions and after a TRH injection. (author).

134

Uptake and Intracellular Activity of Moxifloxacin in Human Neutrophils and Tissue-Cultured Epithelial Cells

We report a whole-genome shotgun assembly (called WGSA) of the human genome generated at Celera in 2001. The Celera-generated shotgun data set consisted of 27 million sequencing reads organized in pairs...Full Text Available

2004-02-17

135

Unloaded Shortening Velocity of Voluntarily and Electrically Activated Human Dorsiflexor Muscles In Vivo

The penetration by moxifloxacin of human neutrophils (polymorphonuclear leukocytes [PMN]) and tissue-cultured epithelial cells (McCoy cells) was evaluated by a fluorometric assay. At...Full Text Available

1999-01-01

136

Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure

We have previously shown that unloaded shortening velocity (V₀) of human plantar flexors can be determined in vivo, by applying the “slack test”...Full Text Available

137

Transcription induces strand-specific mutations at the 5? end of human genes

BackgroundIsoproterenol-induced cardiac hypertrophy in mice has been used in a number of studies to model human cardiac disease. In this study, we compared the transcriptional response...Full Text Available

138

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA_A receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster

A regional analysis of nucleotide substitution rates along human genes and their flanking regions allows us to quantify the effect of mutational mechanisms associated with transcription in germ line...Full Text Available

2008-08-01

139

Theoretical Design of a Gene Therapy To Prevent AIDS but Not Human Immunodeficiency Virus Type 1 Infection

The GABA-modulating and GABA-mimetic activities of the monoterpenoid thymol were explored on human GABA_A and Drosophila melanogaster...Full Text Available

2003-12-01

140

The Relationship of Urinary Metabolites of Carbaryl/Naphthalene and Chlorpyrifos with Human Semen Quality

Recent reports confirm that, due to the presence of long-lived, latently infected cell populations, eradication of human immunodeficiency virus type 1 (HIV-1) from infected patients by using antiretroviral...Full Text Available

2003-09-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

141

Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection

Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between...Full Text Available

2004-12-01

142

Stability of Plasma Human Immunodeficiency Virus Load in VACUTAINER PPT Plasma Preparation Tubes during Overnight Shipment

BackgroundXenotropic Murine Leukemia Virus-related (XMRV) virus is a recently identified mouse gammaretrovirus that has the ability to infect certain human cells. In this study,...Full Text Available

143

Space and the parietal cortex

VACUTAINER PPT plasma preparation tubes were evaluated to determine the effects of various handling and shipping conditions on plasma human immunodeficiency virus (HIV) load determinations. Plasmas...Full Text Available

2000-01-01

144

Should we clone human beings? Cloning as a source of tissue for transplantation.

Current views of the parietal cortex have difficulty accommodating the human inferior parietal lobe (IPL) within a simple dorsal versus ventral stream dichotomy. In humans, lesions of the right IPL...Full Text Available

2007-01-01

145

Shelterin complex and associated factors at human telomeres

The most publicly justifiable application of human cloning, if there is one at all, is to provide self-compatible cells or tissues for medical use, especially transplantation. Some have argued that...Full Text Available

1999-04-01

146

Sequence space coverage, entropy of genomes and the potential to detect non-human DNA in human samples

The processes regulating telomere function have major impacts on fundamental issues in human cancer biology. First, active telomere maintenance is almost always required for full oncogenic transformation...Full Text Available

2011-03-01

147

Sequence features that drive human promoter function and tissue specificity

BackgroundGenomes store information for building and maintaining organisms. Complete sequencing of many genomes provides the opportunity to study and compare global information properties...Full Text Available

148

Promoters are important regulatory elements that contain the necessary sequence features for cells to initiate transcription. To functionally characterize a large set of human promoters, we measured...Full Text Available

2010-07-01

149

STR References 3001-3250

Research on ethics in two large Human Biomonitoring projects ECNIS and NewGeneris: a bottom up approach

Journal of Human Genetics. 82: 873-882. 3134. Schulz, I., Schneider, P. M., Olek, K, Rothschild, M. A., and Tsokos, M. (2006) Examination of Postmortem Animal Interference to Human...

2009-03-16

150

Replication Stress Induces Genome-wide Copy Number Changes in Human Cells that Resemble Polymorphic and Pathogenic Variants

Assessment of ethical aspects and authorization by ethics committees have become a major constraint for health research including human subjects. Ethical reference values often are extrapolated from...Full Text Available

151

Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication

Copy number variants (CNVs) are an important component of genomic variation in humans and other mammals. Similar de novo deletions and duplications, or copy number changes (CNCs), are now known to be...Full Text Available

2009-03-13

152

Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors.

Human cytomegalovirus (HCMV) in clinical material cannot replicate efficiently in vitro until it has adapted by mutation. Consequently, wild-type HCMV differ fundamentally from the passaged strains...Full Text Available

2010-09-01

153

Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545

Hepatitis B virus (HBV) DNA integration has been shown to occur frequently in human hepatocellular carcinomas. We have investigated whether common cellular DNA domains might be rearranged, possibly...Full Text Available

1988-02-01

154

Quantitation of Antibody to Non-Hemagglutinating Viruses by Single Radial Hemolysis: Serological Test for Human Coronaviruses

The aspirin esterase activity of human plasma is due to butyrylcholinesterase and albumin. Our goal was to identify the amino acid residues involved in the aspirin esterase activity of albumin....Full Text Available

2010-03-01

155

Proteome of human colon cancer stem cells: A comparative analysis

A single radial hemolysis test was developed for quantitation of specific antibody to non-hemagglutinating viruses. With the human coronaviruses as models, this test utilizes the binding properties...Full Text Available

1977-06-01

156

Propagation of human embryonic and induced pluripotent stem cells in an indirect co-culture system

AIM: To isolate and identify the biological characteristics of human colon cancer stem cells (SW1116 cells) and further study their proteome.METHODS: SW1116 cells were isolated and cultured with...Full Text Available

2011-03-14

157

Predicting the carcinogenicity of chemicals in humans from rodent bioassay data.

We have developed and validated a microporous poly(ethylene terephthalate) membrane-based indirect co-culture system for human pluripotent stem cell (hPSC) propagation, which allows real-time...Full Text Available

2010-03-05

158

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans. We argue that it is always more useful to...Full Text Available

1991-08-01

159

Polymorphic Regions Affecting Human Height Also Control Stature in Cattle

Human longevity is in part genetically determined, and the insulin/IGF-1 signal transduction (IIS) pathway has consistently been implicated. In humans, type 2 diabetes is a frequent disease that results...Full Text Available

160

Peptides of human bronchial mucus glycoproteins. Size determination by electron microscopy and by biosynthetic experiments.

Orthologous positions of 55 genes associated with height in four human populations were located on the bovine genome. Single nucleotide polymorphisms close to eight of these genes were significantly...Full Text Available

2011-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

161

Pathogenesis of the Human Opportunistic Pathogen Pseudomonas aeruginosa PA14 in Arabidopsis1

Secreted human bronchial mucins, directly collected from macroscopically healthy bronchial mucosa, were prepared in the presence of six proteinase inhibitors, and analysed by electron microscopy. These...Full Text Available

1987-11-15

162

Palindromic Sequence Plays a Critical Role in Human Foamy Virus Dimerization

The human opportunistic pathogen Pseudomonas aeruginosa strain PA14 is a multihost pathogen that can infect Arabidopsis. We found that PA14 pathogenesis in Arabidopsis involves the...Full Text Available

2000-12-01

163

Oxygen deprivation inhibits basal keratinocyte proliferation in a model of human skin and induces regio-specific changes in the distribution of epidermal adherens junction proteins, aquaporin-3, and glycogen

The retroviral RNA genome is dimeric, consisting of two identical strands of RNA linked near their 5′ ends by a dimer linkage structure. Previously it was shown that human foamy virus (HFV)...Full Text Available

2001-04-01

164

Overexpression of human virus surface glycoprotein precursors induces cytosolic unfolded protein response in Saccharomyces cerevisiae

It is generally accepted that hypoxia and recovery from oxygen deprivation contribute to the breakdown and ulceration of human skin. The effects of these stresses on proliferation, differentiation...Full Text Available

2009-01-01

165

Observations on the use of solid-phase-coupled antibodies in the radioimmunoassay of human placental lactogen

BackgroundThe expression of human virus surface proteins, as well as other mammalian glycoproteins, is much more efficient in cells of higher eukaryotes rather than yeasts. The limitations...Full Text Available

166

Numerical field calculations considering the human subject for engineering and safety assurance in MRI

A detailed comparative assessment was made of the use of solid-phase-coupled antibodies in radioimmunoassay, by using an assay for human placental lactogen as a model system. The major advantages of...Full Text Available

1974-03-01

167

Novel Human Erythrovirus Associated with Transient Aplastic Anemia

Numerical calculations of static, switched, and radiofrequency (RF) electromagnetic (EM) fields considering the geometry and EM properties of the human body are used increasingly in MRI to explain...Full Text Available

2009-11-01

168

Nepotistic cooperation in non-human primate groups

Erythrovirus (formerly parvovirus) B19 causes a wide range of diseases in humans, including anemia due to aplastic crisis. Diagnosis of B19 infection relies on serology and the detection of viral DNA...Full Text Available

1999-08-01

169

Natural mutagenesis of human genomes by endogenous retrotransposons

Darwin was struck by the many similarities between humans and other primates and believed that these similarities were the product of common ancestry. He would be even more impressed by the similarities...Full Text Available

2009-11-12

170

NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract

SUMMARYTwo abundant classes of mobile elements, namely Alu and L1 elements, continue to generate new retrotransposon insertions in human genomes. Estimates suggest that these...Full Text Available

2010-06-25

171

Mouse model predicts effects of smoking and varenicline on event-related potentials in humans

BackgroundWe have previously reported that low concentrations of cigarette smoke extract induce DNA damage without leading to apoptosis or necrosis in human bronchial epithelial...Full Text Available

2008-01-01

172

Modulation of the human hair follicle pigmentary unit by corticotropin-releasing hormone and urocortin peptides

Background:Nicotine alters auditory event-related potentials (ERPs) in rodents and humans and is an effective treatment for smoking cessation. Less is known about the effects of...Full Text Available

2010-06-01

173

Mechanistic fracture criteria for the failure of human cortical bone

Human skin is a local source of corticotropin-releasing hormone (CRH) and expresses CRH and CRH receptors (CRH-R) at mRNA and protein levels. Epidermal melanocytes respond to CRH by induction...Full Text Available

2006-05-01

174

Measuring the thickness of the human cerebral cortex from magnetic resonance images

A mechanistic understanding of fracture in human bone is critical to predicting fracture risk associated with age and disease. Despite extensive work, a mechanistic framework for describing how the underlying microstructure affects the failure mode in bone is lacking.

2002-12-13

175

Lotus (Nelumbo nuficera) flower essential oil increased melanogenesis in normal human melanocytes

Accurate and automated methods for measuring the thickness of human cerebral cortex could provide powerful tools for diagnosing and studying a variety of neurodegenerative and psychiatric disorders....Full Text Available

2000-09-26

176

Loss of ?-III spectrin leads to Purkinje cell dysfunction recapitulating the behaviour and neuropathology of SCA5 in humans

In this study, the essential oil from lotus flower extract, including petals and stamens, was assessed with regard to its effects on melanogenesis in human melanocytes. The lotus flower essential oil...Full Text Available

2009-07-31

177

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

Mutations in SPTBN2, the gene encoding β-III spectrin, cause spinocerebellar ataxia type 5 in humans (SCA5), a neurodegenerative disorder resulting in loss of motor...Full Text Available

2010-04-07

178

Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS

Recently, genome-wide association studies (GWAS) have linked the human LIN28B locus to height and timing of menarche [1-Full Text Available

2010-07-01

179

Isolation of Mycoplasma pneumoniae from the human urogenital tract.

BackgroundHuman immunodeficiency virus type 1 (HIV-1) infection frequently causes neurologic disease, which is the result of viral replication and activation of macrophages and microglia...Full Text Available

180

Interaction of the New Ketolide ABT-773 (Cethromycin) with Human Polymorphonuclear Neutrophils and the Phagocytic Cell Line PLB-985 In Vitro

Mycoplasma pneumoniae is a common etiologic agent of lower respiratory tract infections in humans. However, it has been reported previously that the organism has occasionally been isolated from sites...Full Text Available

1995-11-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

181

Individual Predisposition, Household Clustering and Risk Factors for Human Infection with Ascaris lumbricoides: New Epidemiological Insights

A classical velocity centrifugation technique was used to study the in vitro uptake of the new ketolide ABT-773 by human polymorphonuclear neutrophils (PMNs) and a myelomonoblastic cell line, PLB-985,...Full Text Available

2004-04-01

182

Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance

BackgroundMuch of our current understanding of the epidemiology of Ascaris lumbricoides infections in humans has been acquired by analyzing worm count data. These...Full Text Available

183

In vitro dimerization of human immunodeficiency virus type 1 (HIV-1) spliced RNAs

Insulin resistance in skeletal muscle is a key phenotype associated with type 2 diabetes (T2D) for which the molecular mediators remain unclear. We therefore conducted an expression analysis of human...Full Text Available

2011-03-01

184

Impact of sphingomyelin levels on coronary heart disease and left ventricular systolic function in humans

The human immunodeficiency virus type 1 (HIV-1) packages its genomic RNA as a dimer of homologous RNA molecules that has to be selected among a multitude of cellular and viral RNAs. Interestingly, spliced...Full Text Available

2007-12-01

185

Immunoreactive properties of anti-thyroglobulin autoantibodies isolated by affinity chromatography from human thyroiditis serum.

Sphingomyelin (SM) is an abundant phospholipid in cell membranes and in lipoproteins. In human plasma, SM is mainly found in atherogenic lipoproteins; therefore, higher levels of SM may promote atherogenesis....Full Text Available

186

Immunochemical detection of glycated lens crystallins and their circulating autoantibodies in human serum during aging

A Sepharose-coupled 19S human thyroglobulin has been used as an immunoadsorbent to isolate anti-thyroglobulin autoantibodies and to evaluate the antigen-antibody interactions. With the system proposed...Full Text Available

1978-02-01

187

Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species.

PurposeThe aim of this investigation was to exploit lens-specific glycated crystallins as an immunogen to detect human glycated crystallins and their circulating autoantibodies in...Full Text Available

188

Identification of a stem cell candidate in the normal human prostate gland

Simian retroperitoneal fibromatosis (RF) is a vascular fibroproliferative neoplasm which has many morphological and histological similarities to human Kaposi's sarcoma (KS). Like epidemic KS in AIDS...Full Text Available

1997-05-01

189

INTRAVITREAL HUMAN IMMUNE GLOBULIN IN A RABBIT MODEL OF STAPHYLOCOCCUS AUREUS TOXIN-MEDIATED ENDOPHTHALMITIS: A POTENTIAL ADJUNCT IN THE TREATMENT OF ENDOPHTHALMITIS

Stem cells of the human prostate gland have not yet been identified utilizing a structural biomarker. We have discovered a new prostatic epithelial cell phenotype-expressing cytokeratin 6a (Ck6a+...Full Text Available

2005-03-01

190

Human papillomavirus infection in Beijing, People's Republic of China: a population-based study

ABSTRACTObjectivesTo test the feasibility of human immune globulin (IG, Gamimune N, 10%) as a new treatment for endophthalmitis, the ocular tolerance, distribution,...Full Text Available

2004-12-01

191

Human papillomavirus infection and anal carcinoma. Retrospective analysis by in situ hybridization and the polymerase chain reaction.

Background:No recent data exist on human papillomavirus (HPV) infection in Beijing, People's Republic of China.Materials and methodWe interviewed...Full Text Available

2009-11-03

192

Human monkeypox, 1970-79*

To examine the association of human papillomavirus (HPV) infection with anal squamous cell carcinoma, the authors applied the highly sensitive polymerase chain reaction (PCR) and in situ hybridization...Full Text Available

1992-06-01

193

Human milk as a bioindicator for body burden of PCDDs, PCDFs, organochlorine pesticides, and PCBs.

Increasing attention has been given to human monkeypox since the achievement of global smallpox eradication. Monkeypox, which was first described in Central Africa in 1970, resembles smallpox clinically...Full Text Available

1980-01-01

194

Human hair genealogies and stem cell latency

In the State Laboratory of North Rhine-Westphalia for Food, Pharmaceutical and Environmental Chemistry (Chemisches Landesuntersuchungsamt), more than 600 individual human milk samples have been analyzed...Full Text Available

1994-01-01

195

Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses

BackgroundStem cells divide to reproduce themselves and produce differentiated progeny. A fundamental problem in human biology has been the inability to measure how often stem cells...Full Text Available

196

Glycolipids of human primary testicular germ cell tumours.

SUMMARYDendritic cells (DCs) in mucosal surfaces are early targets for human immunodeficiency virus-1 (HIV-1). DCs mount rapid and robust immune responses upon pathogen encounter....Full Text Available

2010-05-28

197

Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction, Increased Virulence, and Genetic Exchange with Human Pathogens

The glycolipid content of human non-seminomatous germ cell tumour cell lines correlates with their differentiation lineage. To analyse whether this reflects the situation in primary tumours, we studied...Full Text Available

1996-07-01

198

Genetics of the mammalian phenylalanine hydroxylase system. Studies of human liver phenylalanine hydroxylase subunit structure and of mutations in phenylketonuria.

The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered....Full Text Available

2009-03-01

199

Genetic heterogeneity in human T-cell leukemia/lymphoma virus type II.

Phenylalanine hydroxylase was purified from crude extracts of human livers which show enzyme activity by usine two different methods: (a) affinity chromatography and (b) immunoprecipitation with an...Full Text Available

1979-08-01

200

Genetic Elucidation of Human Hyperosmia to Isovaleric Acid

DNA from the peripheral blood mononuclear cells of 17 different individuals infected with human T-cell lymphoma/leukemia virus type II (HTLV-II) was successfully amplified by the polymerase chain reaction...Full Text Available

1993-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

201

Gene-Environment Interactions and Epigenetic Basis of Human Diseases

The genetic basis of odorant-specific variations in human olfactory thresholds, and in particular of enhanced odorant sensitivity (hyperosmia), remains largely unknown. Olfactory receptor (OR) segregating...Full Text Available

2007-11-01

202

Gene Signature For Predicting Survival Outcome Of Human Hepatocellular Carcinoma (HCC) - Technology Transfer Center

Most human diseases are related in some way to the loss or gain in gene functions. Regulation of gene expression is a complex process. In addition to genetic mechanisms, epigenetic causes are...Full Text Available

2008-01-01

203

GSFC Information Systems Technology Developments Supporting the Vision for Space Exploration.

The National Cancer Institute Laboratory of Human Carcinogenesis is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize a gene signature for prognosis of hepatocellular carcinoma in patients.

204

Flow Cytometry of Human Primary Epidermal and Follicular Keratinocytes

The Vision for Space Exploration will guide NASA's future human and robotic space activities. The broad range of human and robotic missions now being planned will require the development of new system-level capabilities enabled by emerging new technologie...

2005-01-01

205

Extraction of immune and inflammatory cells from human lung parenchyma: evaluation of an enzymatic digestion procedure.

Objective: The aim of this study was to characterize using flow cytometry cultured human primary keratinocytes isolated from the epidermis and hair follicles by different methods. Methods:...Full Text Available

206

Expression of genes for bone morphogenetic proteins BMP-2, BMP-4 and BMP-6 in various parts of the human skeleton

The inflammatory and immune cell populations of the human lung parenchyma have not been characterized in detail. This report describes a novel and efficient procedure for their extraction. Histologically...Full Text Available

1986-10-01

207

Expression of calbindin-D28k and its regulation by estrogen in the human endometrium during the menstrual cycle

BackgroundDifferences in duration of bone healing in various parts of the human skeleton are common experience for orthopaedic surgeons. The reason for these differences is not obvious...Full Text Available

208

Evolving hard problems: Generating human genetics datasets with a complex etiology

Human endometrium resists embryo implantation except during the 'window of receptivity'. A change in endometrial gene expression is required for the development of receptivity. Uterine calbindin-D28k...Full Text Available

209

Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA.

BackgroundA goal of human genetics is to discover genetic factors that influence individuals' susceptibility to common diseases. Most common diseases are thought to result from the...Full Text Available

210

Epidermal keratinocytes do not activate peripheral T-cells: interleukin-10 as a possible regulator

Chromosomal translocation, deletion, and inversion/duplication directly linked to hepatitis B virus (HBV) DNA integration occur frequently in host DNA of human hepatocellular carcinomas. To test the...Full Text Available

1991-10-15

211

Effects of small doses of ionizing radiation on human health

The immunogenicity of allogeneic cultured human epidermal keratinocytes (cHEKs) has been studied in several models with contradictory results. We studied human T-cell activation in an in vitro...Full Text Available

2008-11-01

212

Effects of small doses of ionizing radiation on human health

The risks to human health from small doses of ionizing radiation raise questions which remain largely unanswered. This paper begins by explaining the historical background to this subject; it goes on to discuss recent developments and concludes with a personal view of the dose-reponse relationship. (author).

1997-12-01

213

Distribution of lead-203 in human peripheral blood in vitro.

The risks to human health from small doses of ionizing radiation raise questions which remain largely unanswered. This paper begins by explaining the historical background to this subject; it goes on to discuss recent developments and concludes with a personal view of the dose-reponse relationship. (author).

1997-01-01

214

Differential Gene Expression in Primary Human Skin Keratinocytes and Fibroblasts in Response to Ionizing Radiation

In-vitro experiments using 203Pb were performed to identify the lead binding components in human peripheral blood. The distribution of lead in plasma, in the red cell membrane, and within the red cell...Full Text Available

1980-02-01

215

Detection and Identification of Bartonella Species Pathogenic for Humans by PCR Amplification Targeting the Riboflavin Synthase Gene (ribC)

Although skin is usually exposed during human exposures to ionizing radiation, there have been no thorough examinations of the transcriptional response of skin fibroblasts and keratinocytes...Full Text Available

2009-07-01

216

Detection and Differentiation of Cryptosporidium spp. in Human Clinical Samples by Use of Real-Time PCR^?

Several Bartonella species have now been implicated as human pathogens. The recovery of these fastidious organisms in the clinical microbiology laboratory remains difficult, and current...Full Text Available

2003-03-01

217

Dengue Fever in Humanized NOD/SCID Mice

Real-time PCR has the potential to streamline detection and identification of Cryptosporidium spp. in human clinical samples. In the present...Full Text Available

2011-03-01

218

Cytokine Responses to Treponema pectinovorum and Treponema denticola in Human Gingival Fibroblasts

The increased transmission and geographic spread of dengue fever (DF) and its more severe presentation, dengue hemorrhagic fever (DHF), make it the most important mosquito-borne viral disease of humans...Full Text Available

2005-11-01

219

Crystallization and preliminary X-ray analysis of human liver ?-enolase

Human gingival fibroblasts were challenged with Treponema pectinovorum and Treponema denticola to test three specific hypotheses: (i) these treponemes induce different...Full Text Available

2000-09-01

220

Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor.

Enolase is a multifunctional enzyme that plays important roles in many biological and disease processes. α-Enolase from human liver (hENO1) was expressed as a soluble protein and purified by...Full Text Available

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

221

Contribution to the radionuclide x-ray fluorescence analysis of human blood and plasma

The three-dimensional structure of the human adenovirus-2 proteinase complexed with its 11 amino acid cofactor, pVIc, was determined at 2.6 A resolution by X-ray crystallographic analysis. The fold...Full Text Available

1996-04-15

222

Confirmation of human Campylobacter concisus isolates misidentified as Campylobacter mucosalis and suggestions for improved differentiation between the two species.

A photon-induced x-ray fluorescence method allowing the simultaneous determination of iron, copper, zinc, bromine and rubidium in human blood and blood plasma samples is described. The method is reliable and has a good sensitivity for a wide range of elements. (author).

1986-04-01

223

Colour television, an imitation of the human visual system.

A strain from human diarrhea originally identified as Campylobacter mucosalis (NCTC 12408) was examined by using 64 phenotypic characters. The similarity of this strain to 297 isolates of Campylobacter,...Full Text Available

1994-09-01

224

Climate Change, Genetics or Human Choice: Why Were the Shells of Mankind's Earliest Ornament Larger in the Pleistocene Than in the Holocene?

Colour television is examined as an attempt to imitate the human visual system in image formation, spectral sensitivities, adaptation, contrast effects, signal processing, signal modulation, signal...Full Text Available

1975-07-01

225

Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family.

BackgroundThe southern African tick shell, Nassarius kraussianus (Dunker, 1846), has been identified as being the earliest known ornamental object used by human...Full Text Available

226

Characterization of discrete classes of binding sites of human serum albumin by application of thermodynamic principles.

The functional gene and three intronless pseudogenes for human triosephosphate isomerase were isolated from a recombinant DNA library and characterized in detail. The functional gene spans 3.5 kilobase...Full Text Available

1985-07-01

227

Characterization of Two Unique Cholesterol-Rich Lipid Particles Isolated from Human Atherosclerotic Lesions

The binding interactions of four ligands differing in acid-base properties with human serum albumin (HSA) were examined as a function of temperature. Binding to HSA decreased with increasing temperature...Full Text Available

1994-08-15

228

Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues.

The authors' laboratory, using histochemicalmethods, previously identified two types of cholesterol-containing lipid particles in the extracellular spaces of human atherosclerotic lesions, one particle...Full Text Available

1990-01-01

229

Cadmium, Lead, and Other Metals in Relation to Semen Quality: Human Evidence for Molybdenum as a Male Reproductive Toxicant

The human CYP3A subfamily is of interest due to its multiplicity, activity toward known carcinogens, and extrahepatic expression. In situ hybridisation analysis of formalin fixed, routinely processed...Full Text Available

1995-02-01

230

Blood velocity measurement in human conjunctival vessels

BackgroundEvidence on human semen quality as it relates to exposure to various metals, both essential (e.g., zinc, copper) and nonessential (e.g., cadmium, lead), is inconsistent....Full Text Available

2008-11-01

231

BK Virus and Human Cancer: Innocent until Proven Guilty

The bulbar conjunctiva is one of the few areas in which blood flow in the peripheral vasculature can be directly and noninvasively observed in the human. Although extensive literature exists describing...Full Text Available

1981-12-01

232

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation

BK virus (BKV) is a polyomavirus that ubiquitously infects the human population. Following a typically subclinical primary infection, BKV establishes a lifelong persistent infection in the kidney...Full Text Available

2009-08-01

233

Assessment of structural changes of human teeth by low-field nuclear magnetic resonance (NMR)

ObjectiveTo address mechanisms that control the activity of human peptidyl arginine deiminase type 4 (PAD-4).MethodsFull Text Available

2010-06-01

234

Application of Cryopreserved Human Hepatocytes in Trichloroethylene Risk Assessment: Relative Disposition of Chloral Hydrate to Trichloroacetate and Trichloroethanol

A technique of low-field pulsed proton nuclear magnetic resonance (NMR) spin relaxation is described for assessment of age-related structural changes (dentin and pulp) of human teeth in...Full Text Available

2010-01-01

235

Appearance of beta-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation.

BackgroundTrichloroethylene (TCE) is a suspected human carcinogen and a common ground-water contaminant. Chloral hydrate (CH) is the major metabolite of TCE formed in the liver by...Full Text Available

2006-08-01

236

Apoptosis of human seminoma cells upon disruption of their microenvironment.

beta-Endorphin-like immunoreactivity in human ventricular cerebrospinal fluid was measured with a specific radioimmunoassay. The subjects were undergoing a surgical procedure for relief of chronic intractable...Full Text Available

1978-10-01

237

Antigenic analysis of the second extra-cellular loop of the human beta-adrenergic receptors.

One of the main obstacles encountered when trying to culture human seminoma (SE) cells in vitro is massive degeneration of the tumour cells. We investigated whether dissociation of tumour tissue, to...Full Text Available

1996-05-01

238

Anti-beta-endorphin immunoglobulin G in humans.

Polyclonal antibodies were raised in rabbits by immunization with free peptides corresponding to positions 197-222 of the human beta 1-adrenergic receptor (beta 1 peptide) and the corresponding sequence...Full Text Available

1989-10-01

239

Angular distribution of environmental radiation incident on humans; and reply

Human IgG specific for beta-endorphin was identified by enzyme-linked immunoabsorbent assay and isolated by affinity chromatography. From a sample of 27 subjects, three individuals with major depression...Full Text Available

1986-11-01

240

Actin-like sequences are present on human X and Y chromosomes.

A brief letter attempts to justify the assumption in an earlier paper of an isotropic distribution of environmental gamma rays incident on humans. A second letter from the original authors responds to this in yet more detail. (UK).

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

241

A semi-qualitative study of attitudes to vaccinating adolescents against human papillomavirus without parental consent

The human genome contains greater than 20 actin-related sequences, six of which at least are expressed as protein. We have shown by blot hybridization the presence of actin-like sequences on both the...Full Text Available

1984-08-01

242

A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication.

BackgroundThe first vaccine to prevent human papillomavirus (HPV) and cervical cancer has been licensed, and in future, vaccination may be routinely offered to 10–14 year...Full Text Available

243

A second generation human haplotype map of over 3.1 million SNPs

We recently reported that human immunodeficiency virus type 1 (HIV-1) unintegrated linear DNA displays a discontinuity in its plus strand, precisely defined by a second copy of the polypurine tract...Full Text Available

1992-05-01

244

A naturally occurring human antibody to loops of Henle

We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and...Full Text Available

2007-10-18

245

A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells

A hitherto unreported immunofluorescent staining pattern obtained from human sera is described. Serum from six patients was found to possess specific antibody activity against lining cells of loops...Full Text Available

1973-08-01

246

A gene expression signature shared by human mature oocytes and embryonic stem cells

OBJECTIVEPreimplantation factor (PIF) is a novel, 15 amino acid peptide, secreted by viable embryos. This study aims to elucidate PIF’s effects in human endometrial...Full Text Available

2010-05-01

247

A Controlled Challenge Study on Di(2-ethylhexyl) Phthalate (DEHP) in House Dust and the Immune Response in Human Nasal Mucosa of Allergic Subjects

BackgroundThe first week of human pre-embryo development is characterized by the induction of totipotency and then pluripotency. The understanding of this delicate process will have...Full Text Available

248

45 CFR 1304.24 - Child mental health.

BackgroundFew studies have yet addressed the effects of di(2-ethylhexyl) phthalate (DEHP) in house dust on human nasal mucosa.ObjectivesWe investigated...Full Text Available

2008-11-01

249

Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells

... 2010-10-01 false Child mental health. 1304.24 Section 1304.24 Public...HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION...AGENCIES Early Childhood Development and Health Services § 1304.24 Child...

2010-10-01

250

jahresbericht6.5NEU

Wastenet

The industrial revolution changed the pattern of human interaction with nature profoundly.Not only did social metabolism

251

Significance of the Human Being as an Element in an ...

Full Text Available

2011-03-01

252

Release 01-93 - NASA Human Space Flight

... Montgomery's diversionary plan called Goodwood. The goal ... Montgomery's Operation Goodwood began with a huge air armada attack on German ...

2002-03-01

253

RAYMAN: A FORTRAN Computer Code for Tracing Rays ...

These cutting-edge developments will be used for future government and commercial launch systems and space transportation operations. ...

254

Palo Verde control room human study: results

... Descriptors : *COMPUTERIZED SIMULATION, *HUMAN BODY, *WOUND BALLISTICS, COMPUTER PROGRAMS, PROJECTILES, MATRICES ...

1977-11-01

255

Palo Verde control room human factors study: methodology

(1981). United States Guidetti, RP Luna, SF Rowland, JW Bechtel, Downey,

256

Interpreting Mammalian Evolution using Fugu Genome Comparisons

(1981). United States Guidetti, RP Luna, SF Rowland, JW Bechtel, Downey,

257

Interaction Of Human La Protein With The Internal Ribosome Entry Site Of Hepatitis C Virus : Functional Role In Mediating Internal Initiation Of Translation

Comparative sequence analysis of the human and the pufferfish Fugu rubripes (fugu) genomes has revealed several novel functional coding and noncoding regions in the human genome. In particular, the fugu genome has been extremely valuable for identifying transcriptional regulatory elements in human loci harboring unusually high levels of evolutionary conservation to rodent genomes. In such regions, the large evolutionary distance between human and fishes provides an additional filter through which functional noncoding elements can be detected with high efficiency.

2004-04-02

258

Indian Institute of Science Theses & Dissertations (India)

Full Text Available

2004-07-01

259

Improved Usability of Locomotion Devices Using Human ...

Human Systems Center Products and Progress.

... increasing photorealism. Furthermore, developments in audio technology continue to increase the spatial awareness of users in VEs. ...

2009-03-01

260

Human Auditory Localization Performance in Azimuth

... Page 43. Integrated Audio Technology Demonstrator The Integrated Audio Technology Dem- development for this application is successful. ...

1993-10-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

261

Effect of dietary constituents on the absorption of lead in the human

... The realization of directional audio technology in the cockpit may reduce visual workload, enhance the presentation of flight and threat information ...

1991-01-01

262

Development of Jelly-Type Simulating Polymer Based Human Tissue for Research on Hyperthermia by High Frequency Magnetic Field

... biological effects body burden diet intestinal absorption lead lead 203 man

1983-03-01

263

Correlation between the amount of natural uranium present in diet and its uptake by the human skeleton

Full Text Available

2006-11-01

264

Considerations in the Design and Development of a Human ...

... alpha spectroscopy comparative evaluations diet electroplating men natural

265

Circuitry for a Wireless Microsystem for Neural Recording ...

... appropriate. At press time, the laws governing the use of digital audio technology and the technology itself are rapidly changing. ...

1990-09-20

266

Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein

... in artificial intelligence, human physiology and biomedical prosthesis. ... central and peripheral nerve systems [1 ... CMOS circuit interface for multiplexed ...

2001-10-25

267

Chromosomal damage in human lymphocytes from radio-isotope therapy

Human BTEB cDNA clones have been isolated, sequenced, and the corresponding gene has been assigned to human chromosome 9, region q13, by fluorescent in situ hybridization and DNA blot analysis using DNAs from hybrid cell clones containing a single human chromosome. The cDNA clone encodes a polypeptide of 244 amino acids whose sequence shows a high sequence similarity with the rat BTEB (98% amino acid identity).

1993-09-01

268

Aliens in Antarctica - GCMD - NASA

(Dec 1973). United Kingdom Stevenson, AC Medical Research Council, Oxford

269

Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans.

International Polar Year (IPY) Aliens in Antarctica will assess the threat of humans carrying non-native seeds and spores into Antarctica. ...

270

Accommodation, Acuity, and their Relationship to Emmetropization in Infants

Udgivelsesdato: 2003-Apr-15

2003-01-01

271

PurposeTo evaluate the relationship between accommodation, visual acuity, and emmetropization in human infancy.MethodsFull Text Available

2009-06-01

272

27 - NASA

Urban Atmospheric Science

02.10.10 - NASA and Texas Instruments are using the theme of human space exploration to develop digital libraries of math and science problems for high ...

273

Environmental Research Database

DescriptionThis new research programme activity on Urban Atmospheric Science will deliver aspects of the NERC strategy: Next Generation Science for Planet Earth. It has been developed as part of the Environment, Pollution & Human Health theme. Research in the Environment, Pollution & Human Health theme is directed at elucidating key environmental processes that form part of a causal pathway between an environmental hazard and disease outcome, and providing a predictive capability of the risk to human heal [continued...

2012-01-01

274

The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding.

Synthesis and cloning of the genes of antisense peptides of human calcitonin and miniproinsulin

We have isolated and sequenced cDNA clones encoding the human U1-70K snRNP protein, and have mapped this locus (U1AP1) to human chromosome 19. The gene produces two size classes of RNA, a major 1.7-kb...Full Text Available

1987-12-23

275

Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8⁺-T-Cell Epitopes Recognized

With the aim of an experimental check on the validity of the theory of molecular recognition, the authors have carried out the chemical-enzymatic synthesis and cloning of the gene of human calcitonin and also of the genes of antisense polypeptides to human calcitonin and miniproinsulin. It has been shown that recombinant plasmids obtained on the basis of these synthetic genes are capable of ensuring the biosynthesis of the given polypeptides in E. coli cells as hybrid proteins with the IgG-binding domain of staphylococcal protein A.

1994-07-20

276

Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control.

We studied the effect of booster injections and the long-term immune response after injections of an anti-human immunodeficiency virus type 1 (HIV-1) lipopeptide vaccine. This vaccine was injected alone...Full Text Available

2003-10-01

277

Human error and experienced feedback during refuelling overhauling of Daya Bay Nuclear Power Station

We have isolated a human thrombomodulin cDNA, and a human genomic clone containing the putative promoter domain, as well as the translated and untranslated regions of the endothelial cell receptor....Full Text Available

1987-09-01

278

Contribution to the in vitro multielement X-ray fluorescence analysis of human soft tissues

The authors describe the various human error encountered during Daya bay refueling overhaul, and the subsequent root cause evaluation and protective measure. Authors consider transparency is the key in reducing human error and event recurrence. Additional y, event transparency will enhance the effectiveness if experience feedback and reduce event consequence

2000-10-01

279

Chimeric Matrix Proteins Encoded by Defective Proviruses with Large Internal Deletions in Human T-Cell Leukemia Virus Type 1-Infected Humans

Determination of Mn, Fe, Ni, Cu, Zn, and Pb in human soft tissues by radionuclide X-ray fluorescence analysis (using "2"3"8Pu and "1"0"9Cd sources) is described. The results of multielement XRS analysis of selected human tissues are tabulated. They are in good agreement with the literature data. It is concluded that X-ray fluorescence technique is a suitable method for trace element determination. (author).

1986-11-01

280

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and other diseases....Full Text Available

2000-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

281

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

The human causal factors for all human error licensing operational events on Daya Bay nuclear power station since 1993 to 2003 are categorized, the trend of these causal factors is analyzed. The emphasis is placed on analyzing the deficiencies on complying with and executing regulations and procedures. The results provide directional reference for nuclear power station to improve human performance. (author)

2005-09-01

282

Activation of Metallothioneins and ?-Crystallin/sHSPs in Human Lens Epithelial Cells by Specific Metals and the Metal Content of Aging Clear Human Lenses

A series of translocation break points found in a subset of human acute leukemias have one of the breaks on human chromosome 11q23. This region has recently been cloned and a large gene, ALL-1, with...Full Text Available

1993-07-01

283

A single-stranded gap in human immunodeficiency virus unintegrated linear DNA defined by a central copy of the polypurine tract.

PurposeTo identify those metallothionein and α-crystallin/small heat-shock genes induced by toxic metals in human lens cells and to evaluate...Full Text Available

2003-02-01

284

A Human Reliability Analysis of Pre-Accident Human Errors in the Low Power and Shutdown PSA of the KSNP

The structure of unintegrated human immunodeficiency virus type 1 (HIV-1) DNA from acutely infected human lymphoid cells was analyzed by nuclease S1 cleavage. We observed a unique, discrete single-stranded...Full Text Available

1991-05-01

285

Specificity of the human proteoglycan radioimmunoassay

Korea Atomic Energy Research Institute, using the ANS Low Power /Shutdown (LPSD)PRA Standard, evaluated the LPSD PSA model of the KSNP, Younggwang (YGN) Units 5 and 6, and identified the items to be improved. The evaluation results of human reliability analysis (HRA) of the pre-accident human errors in the LPSD PSA model of the KSNP showed that 13 items among 15 items of supporting requirements for those in the ANS PRA Standard were identified as them to be improved. Thus, we newly carried out a HRA for pre-accident human errors in the LPSD PSA model for the KSNP to improve its quality. We considered potential pre-accident human errors for all manual valves and control/instrumentation equipment of the systems modeled in the KSNP LPSD PSA model except reactor protection system/ engineering safety features actuation system. We reviewed 160 manual valves and 56 control/instrumentation equipment. The number ...

2003-04-20

286

Investigating the biological and clinical significance of human dysbioses

The human articular cartilagineous proteoglycans (PG) R.I.A. is highly specific. The PG used as the standard and the /sup 125/I labelled molecule appear to be pure. Under these conditions, all the potential interfering substances which have been tested show no cross reaction. For instance, the Ag-Ab equilibrium is not affected by adding human IgG, human albumin, hyaluronic acid, chondroitin sulfate, rat type II collagen or total human serum proteins. This R.I.A. also exhibits a species spcificity since there is no cross reaction with rat PG and negligible cross section with dog PG. The results obtained after addition of enzymes to the antigen demonstrate that the antigenic sites are localized on the protein region and not on the glycosaminoglycan region of the molecule.

1981-01-01

287

British Library Electronic Table of Contents (United Kingdom)

Culture-independent microbiological technologies that interrogate complex microbial populations without prior axenic culture, coupled with high-throughput DNA sequencing, have revolutionized the scale, speed and economics of microbial ecological studies. Their application to the medical realm has led to a highly productive merger of clinical, experimental and environmental microbiology. The functional roles played by members of the human microbiota are being actively explored through experimental manipulation of animal model systems and studies of human populations. In concert, these studies have appreciably expanded our understanding of the composition and dynamics of human-associated microbial communities (microbiota). Of note, several human diseases have been linked to alterations in th...

2011-01-01

288

Human reliability analysis in Wolsung 2/3/4 nuclear power plants probabilistic safety assessment

Human reliability analysis in Wolsong 2/3/4 nuclear power plants probabilistic safety assessment

The Level 1 probabilistic safety assessment (PSA) for Wolsung(WS) 2/3/4 nuclear power plant (NPPs) in design stage is performed using the methodologies being equivalent to PWR PSA. Accident sequence evaluation program (ASEP) human reliability analysis (HRA) procedure and technique for human error rate prediction (THERR) are used in HRA of WS 2/3/4 NPPs PSA. The= purpose of this paper is to introduce the procedure and methodology of HRA in WS 2/3/4 NPPs PSA. Also, this paper describes the interim results of importance analysis for human actions modeled in WS 2/3/4 PSA and the findings and recommendations of administrative control of secondary control area from the view of human factors. (Author) 10 refs., 2 tabs.

1997-05-01

289

Field test studies of our infrared-based human temperature screening system embedded with a parallel measurement approach

The Level 1 probabilistic safety assessment (PSA) for Wolsong(WS) 2/3/4 nuclear power plant(NPPs) in design stage is performed using the methodologies being equivalent to PWR PSA. Accident sequence evaluation program (ASEF) human reliability analysis (HRA) procedure and technique for human error rate prediction (THERP) are used in HRA of WS 2/3/4 NPPs PSA. The purpose of this paper is to introduce the procedure and methodology of HRA in WS 2/3/4 NPPs PSA. Also, this paper describes the interim results of importance analysis for human actions modeled in WS 2/3/4 PSA and the findings and recommendations of administrative control of secondary control area from the view of human factors.

1997-05-01

290

British Library Electronic Table of Contents (United Kingdom)

This paper introduces a parallel measurement approach for fast infrared-based human temperature screening suitable for use in a large public area. Our key idea is based on the combination of simple image processing algorithms, infrared technology, and human flow management. With this multidisciplinary concept, we arrange as many people as possible in a two-dimensional space in front of a thermal imaging camera and then highlight all human facial areas through simple image filtering, image morphological, and particle analysis processes. In this way, an individual's face in live thermal image can be located and the maximum facial skin temperature can be monitored and displayed. Our experiment shows a measured 1ms processing time in highlighting all human face areas. With a thermal imaging ca...

2009-01-01

291

Cloning of the cDNA and gene for a human D sub 2 dopamine receptor

Cause analysis and preventives for human error events in Daya Bay NPP

A clone encoding a human D{sub 2} dopamine receptor was isolated from a pituitary cDNA library and sequenced. The deduced protein sequence is 96% identical with that of the cloned rat receptor with one major difference: the human receptor contains an additional 29 amino acids in its putative third cytoplasmic loop. Southern blotting demonstrated the presence of only one human D{sub 2} receptor gene. Two overlapping phage containing the gene were isolated and characterized. DNA sequence analysis of these clones showed that the coding sequence is interrupted by six introns and that the additional amino acids present in the human pituitary receptor are encoded by a single exon of 87 base pairs. The involvement of this sequence in alternative splicing and its biological significance are discussed.

1989-12-01

292

A novel glioblastoma cancer gene therapy using AAV-mediated long-term expression of human TERT C-terminal polypeptide

Daya Bay Nuclear Power Plant is put into commercial operation in 1994 Until 1996, there are 368 human error events in operating and maintenance area, occupying 39% of total events. These events occurred mainly in the processes of maintenance, test equipment isolation and system on-line, in particular in refuelling and maintenance. The author analyses root causes for human errorievents, which are mainly operator omission or error procedure deficiency; procedure not followed; lack of training; communication failures; work management inadequacy. The protective measures and treatment principle for human error events are also discussed, and several examples applying them are given. Finally, it is put forward that key to prevent human error event lies in the coordination and management, person in charge of work, and good work habits of staffs.

293

British Library Electronic Table of Contents (United Kingdom)

Glioblastoma multiforme is the most aggressive form of human brain tumor, which has no effective cure. Previously, we have demonstrated that overexpression of the C-terminal fragment of the human telomerase reverse transcriptase (hTERTC27) inhibits the growth and tumorigenicity of human cervical cancer HeLa cells. In this study, the therapeutic effect and molecular mechanisms of hTERTC27-mediated cancer gene therapy were further explored in vivo in established human glioblastoma xenografts in nude mice. We showed that intratumoral injection of adeno-associated virus carrying hTERTC27 (rAAV-hTERTC27) is highly effective in reducing the growth of the subcutaneously transplanted glioblastoma tumors. Histological analyses showed that rAAV-hTERTC27 treatment leads to profound necrosis, apoptosi...

2007-01-01

294

Animal and human studies of a new /sup 99m/Tc labelled phosphine-isocyanide complex with possible applications to radionuclide ventriculography

The p75"N"T"R tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells

A new /sup 99m/Tc-phosphine-isocyanide complex with the general structure (/sup 99m/Tc (DEPE)/sub 2/(CNR)/sub 2/)/sup +/ has been synthesised and tested in animals and one human. In three animal species (rat, rabbit, dog), the complex is an efficient myocardial imaging agent, while in humans it remains in the blood pool. The complex is 100% protein bound in animals and humans, but whereas in humans it is attached to a 51.5 kdalton protein (probably prealbumin), in rabbits it appears to be bound to a larger macromolecule (M.W.>100 kdalton). The efficiency of the complex for blood pool labelling was tested in a human volunteer and compared with the standard in vivo red cell labelling technique with stannous pyrophosphate. A satisfactory radionuclide angiogram could be performed with less than 370 MBq of the complex. The count rate for the complex (cps/MBq) was 15% higher than that ...

1987-04-01

295

Process-integrated online monitoring of safety-relevant aluminum airbag pressure vessel components for a combined defect detection and material property determination by using contactless NDT (EMUS and EC)

The p75 neurotrophin receptor (p75"N"T"R) is a death receptor which belongs to the tumor necrosis factor receptor super-family of membrane proteins. This study shows that p75"N"T"R retarded cell cycle progression by induced accumulation of cells in G0/G1 and a reduction in the S phase of the cell cycle. The rescue of tumor cells from cell cycle progression by a death domain deleted (#DELTA#DD) dominant-negative antagonist of p75"N"T"R showed that the death domain transduced anti-proliferative activity in a ligand-independent manner. Conversely, addition of NGF ligand rescued retardation of cell cycle progression with commensurate changes in components of the cyclin/cdk holoenzyme complex. In the absence of ligand, p75"N"T"R-dependent cell cycle arrest facilitated an increase in apoptotic nuclear fragmentation of the prostate cancer cells. Apoptosis of p75"N"T"R expressing cells occurred via the intrinsic mitochondrial pathway leading to a sequential caspase-9 and ...

2006-03-24

296

Interobserver agreement in ultrasonography of the finger and toe joints in rheumatoid arthritis.

Airbag pressure vessels for the north-American market mainly are made by forging and by the use of steel alloys. In Europe aluminum alloys are common and the manufacturing process is extrusion of circular blanks - made from cold rolled plates - in a form applying a 100 t press at room temperature. Then by heat treatment the strength/hardness of the material is properly adjusted and after that the pressure vessel parts have to be continuously inspected with an inspection and handling cycle time of 3 s. Inspection of the axis-symmetric parts is asked for surface breaking extrusion defects as well as for surface parallel delaminations in the bulk volume. Furthermore, the material strength is a quality characteristic that has to be nondestructively registered and documented. The inspection is performed by eddy current probes and an EMAT, of which the eddy current impedance measurements are used for surface breaking extrusion defect detection and sizing (single frequency technique with ...

1999-07-01

297

Field investigation of a wake structure downwind of a VAWT in a windfarm array

OBJECTIVE: To evaluate the interobserver agreement of ultrasonographic assessment of finger and toe joints in patients with rheumatoid arthritis (RA) by 2 investigators with different medical backgrounds. METHODS: Ultrasonography and clinical examination were performed on 150 small joints of 30 patients with active RA. A General Electric LOGIQ 500 ultrasound unit with a 7-13-MHz linear array transducer was used. In each patient, 5 preselected small joints (second and third metacarpophalangeal, second proximal interphalangeal, first and second metatarsophalangeal) were examined independently on the same day by 2 ultrasound investigators (an experienced musculoskeletal radiologist and a rheumatologist with limited ultrasound training). Joint effusion, synovial thickening, bone erosions, and power Doppler signal were evaluated in accordance with an introduced 4-grade semiquantitative scoring system, on which the investigators had reached consensus prior to the study. ...

2003-01-01

298

Endoluminal ultrasound applicator with an integrated RF coil for high-resolution magnetic resonance imaging-guided high-intensity contact ultrasound thermotherapy

The effects of upwind turbine wakes on the performance of a FloWind 17-m VAWT were investigated through a series of field experiments conducted at the FloWind windfarm on Cameron Ridge, Tehachapi, California. The field experiment was conducted within a VAWT array consisting of more than nine VAWTs with separations 3D crosswised by 8D downwind (where D is the turbine diameter) in a staggered configuration. The array is the upwind three rows of VAWTS in a total of six rows that are on top of the Cameron Ridge plateau. The terrain features in the vicinity are reasonably regular, with an upslope of 7 deg on the average; however, several local irregularities are present. The annual hourly averaged wind speed exceeds 8 m/s at the site. The wind field and the power-outputs of nine turbines within the array were measured with wind sensors and power transducers. Nine Gill propeller and 18 Maximum cup anemometers and one direction sensor were mounted on portable and stack-up ...

1987-10-01

299

Deliberate ignition of hydrogen-air-steam mixtures in condensing steam environments

High-intensity contact ultrasound (HICU) under MRI guidance may provide minimally invasive treatment of endocavitary digestive tumors in the esophagus, colon or rectum. In this study, a miniature receive-only coil was integrated into an endoscopic ultrasound applicator to offer high-resolution MRI guidance of thermotherapy. A cylindrical plastic support with an incorporated single element flat transducer (9.45 MHz, water cooling tip) was made and equipped with a rectangular RF loop coil surrounding the active element. The integrated coil provided significantly higher sensitivity than a four-element extracorporeal phased array coil, and the standard deviation of the MR thermometry (SDT) improved up to a factor of 7 at 10 mm depth in tissue. High-resolution morphological images (T1w-TFE and IR-T1w-TSE with a voxel size of 0.25 x 0.25 x 3 mm3) and accurate thermometry data (the PRFS method with a voxel size of 0.5 x 0.5 x 5 mm3, 2.2 s/image, 0.3 deg. C voxel-wise SDT) ...

2008-11-21

300

Comparison between experimental data and numerical modeling for the natural circulation phenomenon

Large scale experiments were performed to determine the effectiveness of thermal glow plug igniters to burn hydrogen in a condensing steam environment due to the presence of water sprays. The experiments were designed to determine if a detonation or accelerated flame could occur in a hydrogen-air-steam mixture which was initially nonflammable due to steam dilution but was rendered flammable by rapid steam condensation due to water sprays. Eleven Hydrogen Igniter Tests were conducted in the test vessel. The vessel was instrumented with pressure transducers, thermocouple rakes, gas grab sample bottles, hydrogen microsensors, and cameras. The vessel contained two prototypic engineered systems: (1) a deliberate hydrogen ignition system and (2) a water spray system. Experiments were conducted under conditions scaled to be nearly prototypic of those expected in Advanced Light Water Reactors (such as the Combustion Engineering (CE) System 80+), with prototypic spray drop ...

1997-05-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

301

Clinical and ultrasonographic findings, diagnosis and treatment of pyelonephritis in 17 cows.

There is a crescent interest in the scientific community in the study of natural circulation phenomenon. New generation of compact nuclear reactors uses the natural circulation of the fluid as a system of cooling and of residual heat removal in case of accident or shutdown. The objective of this paper is to present a study through the comparison of experimental data and numerical simulation for the natural circulation phenomenon in one and two-phase flow regime. An experimental circuit built with glass tubes is used for the experiments. Thus, it allows the thermal hydraulic phenomena visualization. There is an electric heater as the heat source, a heat exchanger as the heat sink and an expansion tank to accommodate fluid density excursions. The circuit instrumentation consists of thermocouples and pressure meters to better keep track of the flow and heat transfer phenomena. Instrumentation data acquisition is performed through a computer interface developed with LABVIEW. Previous ...

2009-07-01

302

Integrated design environment for human performance and human reliability analysis

The goal of the present study was to describe the clinical, haematological and ultrasonographic findings and treatment of 17 cattle with pyelonephritis. Fifteen cattle had an abnormal general condition, which varied in severity; five animals had signs of colic. The urine was brownish-red in 11 animals and cloudy in 13. Clumps of purulent material were seen in the urine of nine animals and clots of blood in two. The specific gravity was lower than normal in 13 animals and ranged from 1.005 to 1.020. A urine test strip revealed protein in 16 animals, blood in 16 and leukocytes in 12. Bacteriological examination of urine yielded Corynebacterium renale in 11 animals, Arcanobacter pyogenes in two and Escherichia coli in one. Rectal examination revealed abnormalities of the urinary tract in 11 animals; there was dilatation of the left ureter and/or enlargement of the left kidney in eight cases, and dilatation of the right ureter and/or enlargement of the right kidney in three others. The ...

2007-03-23

303

A Human reliability analysis of post-accident human errors in the PSA of KSNP

Work over the last few years at the Idaho National Engineering and Environmental Laboratory (INEEL) has included a major focus on applying human performance and human reliability knowledge and methods as an integral element of system design and development. This work has been pursued in programs in a wide variety of technical domains, beginning with nuclear power plant operations. Since the mid-1980`s the laboratory has transferred the methods and tools developed in the nuclear domain to military weapons systems and aircraft, offshore oil and shipping operations, and commercial aviation operations and aircraft design. Through these diverse applications the laboratory has developed an integrated approach and framework for application of human performance analysis, human reliability analysis (HRA), operational data analysis, and simulation studies of human performance to the design ...

1997-05-01

304

Regulation of human ribosomal RNA transcription.

Korea Atomic Energy Research Institute, using the ASME PRA Standard, evaluated the PSA model of the Korea Standard Nuclear Power Plant (KSNP) and identified the items to be improved to enhance its quality. The new risk monitor PSA model for the KSNP of which quality was enhanced is called as PRiME-U3i. The evaluation results of human reliability analysis (HRA) of the post-accident human errors in the PSA model of the KSNP showed that 10 items among 19 items of supporting requirements for those in the ASME PRA Standard were identified as them to be improved. Thus, we newly carried out a HRA for post-accident human errors for the KSNP PSA model as the target of grading its quality above ASME PRA Standard Category I+. Following tasks were additionally major tasks performed in the HRA of post-accident human errors of PRiME-U3i compared with the previous PSA model of the KSNP: interviews with operators in ...

2004-10-28

305

In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins.

We have used a cell-free polymerase I transcription system derived from HeLa cells to study the regulation of human rRNA synthesis. Analysis of deletion mutants spanning the start site of transcription at nucleotide +1 indicates that the control region affecting initiation of human rRNA synthesis is contained within sequences from nucleotides -158 to +18. This promoter region can be subdivided into (i) a central segment of approximately 40 base pair that is required for transcription and (ii) flanking sequences that influence the efficiency of transcription in vitro. We have examined the in vitro transcriptional activity of the human extract under various conditions that are thought to modulate rRNA synthesis in vivo. Cell-free extracts prepared from HeLa cells infected with adenovirus 2 synthesize human rRNA at levels greatly decreased relative to uninfected cell extracts. By contrast, in vitro ...

1983-06-01

306

Cloning and expression of a human kidney cDNA for an /alpha//sub 2/-adrenergic receptor subtype

The gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), replicates to high titers in some human cell lines and is able to infect non-human primates. To determine whether APOBEC3 (A3) proteins restrict XMRV infections in a non-human primate model, we sequenced proviral DNA from peripheral blood mononuclear cells of XMRV-infected rhesus macaques. Hypermutation characteristic of A3DE, A3F and A3G activities was observed in the XMRV proviral sequences in vivo. Furthermore, expression of rhesus A3DE, A3F, or A3G in human cells inhibited XMRV infection and caused hypermutation of XMRV DNA. These studies show that some rhesus A3 isoforms are highly effective against XMRV in the blood of a non-human primate model of infection and in cultured human cells. PMID:21982221

2011-10-01

307

Chromosomal localization of the human retinoid X receptors

An /alpha//sub 2/-adrenergic receptor subtype has been cloned from a human kidney cDNA library using the gene for the human platelet /alpha//sub 2/-adrenergic receptor as a probe. The deduced amino acid sequence resembles the human platelet /alpha//sub 2/-adrenergic receptor and is consistent with the structure of other members of he family of guanine nucleotide-binding protein-coupled receptors. The cDNA was expressed in a mammalian cell line (COS-7), and the /alpha//sub 2/-adrenergic ligand (/sup 3/H)rauwolscine was bound. Competition curve analysis with a variety of adrenergic ligands suggests that this cDNA clone represents the /alpha//sub 2/B-adrenergic receptor. The gene for this receptor is on human chromosome 4, whereas the gene for the human platelet /alpha//sub 2/-adrenergic receptor (/alpha//sub 2/A) lies on chromosome 10. This ability to express the receptor in mammalian ...

1988-09-01

308

Justice and the Human Genome Project

The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). In this work, the authors report high-resolution localization of the human RXR genes within cytogenetic bands and also within a standard reference map of cosmid DNA markers on human chromosomes. They have determined the location of the human RXR genes by pairwise hybridization of the RXR cosmids and reference markers, using fluorescence in situ hybridization. They localized (i) RXR[alpha] (RXRA) to chromosome 9 band q34.3; (ii) RXR[beta] (RXRB) to chromosome 6 band 21.3; and (iii) RXR[gamma] (RXRG) to chromosome 1 band q22-q23. Six retinoid-responsive transcription factors have been identified so far, including three retinoic acid receptors in addition to the three RXRs. Interestingly, ...

1994-04-01

309

Exons, Introns and Talking Genes: The Sience Behind the Human Genome Project

Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

1992-01-01

310

Educational research in Mainland China: current situation and developmental trends

This book presents in simple terms the basis of molecular genetics and how it is used to obtain an understanding of the human genome. The author's central focus is the transistion of genetics from statistics to experimental manipulations, and he offers analogies that help readers visualize the genome, thereby avoiding conventional scientific presentations. He illustrates how genetics is used in scientific laboratories, in courtrooms, and in hospitals. Little is presented about the complex social and ethical issues raised by the Human Genome project.

1993-01-01

311

British Library Electronic Table of Contents (United Kingdom)

The influence of Confucian culture in Chinese Mainland China is reflected in the current situation and contextual trends of educational research content of educational thought of Confucianism, educational issues grounded on theoretical views of Confucianism, and the influence of the inclusiveness of Confucianism. In terms of research method, the current situation of educational research is reflected in empirical research whose methods value the construction of the metaphysical theoretical system, the guiding role of educational theories for educational reform practice, and research that enriches the literature. In terms of research value, the current situation of educational research is reflected in studies that focus on human nature, human relations, thoughts, willpower, emotion, human ri...

2011-01-01

312

Analysis of brain CT on 120 patients of human cysticercosis

Transhumanism, medical technology and slippery slopes

A study on brain CT was made in 120 patients of human cysticercosis, which is a rare disease in Japan and clinical symptoms and laboratory data for the diagnosis were also discussed. From the point of therapeutic view, we proposed a new differentiation on brain CT of human cysticercosis, which is divided into two groups according to the alve or dead parasite. Furthermore, we proposed a new type named multiple large and small cysts type on brain CT. The idea of diagnostic standard was made integrating brain CT image, clinical symptoms and labolatory data. (author).

313

Titration of diphtheria and tetanus antitoxins in sera of low titre

In this article, transhumanism is considered to be a quasi‐medical ideology that seeks to promote a variety of therapeutic and human‐enhancing aims. Moderate conceptions are distinguished...Full Text Available

2006-09-01

314

Thermal neutron capture therapy for human cutaneous malignant melanoma at Kyoto university reactor. {sup 10}B{sub 1}-BPA administration and radiation dose determination

Available methods for titrating diphtheria and tetanus antitoxin at low concentrations in human or animal blood are surveyed, with special attention to the amount of serum required for the test....Full Text Available

1971-01-01

315

The Elastic Properties of the Cryptococcus neoformans Capsule

Short communication.

1994-06-01

316

The BCNT treatment planning for the Brookhaven trials on human gliomas

AbstractMicrobial capsules are important for virulence, but their architecture and physical properties are poorly understood. The human pathogenic fungus Cryptococcus neoformans...Full Text Available

2009-08-19

317

The Allometry of Host-Pathogen Interactions

Boron neutron capture therapy (BNCT) trials for human glioma (glioblastoma multiform) were initiated September 1994 at the Brookhaven National Laboratory (BNL). Patients are given p-boronophenylalanine-fructose (BPA-F) intravenously as the boron carrier followed by exposure to the epithermal-neutron beam at the Brookhaven Medical Research Reactor (BMRR). The initial phase of the study is to determine safety and toxicity of the drug and irradiation procedure. The epithermal-neutron beam was developed in a joint effort by BNL and Idaho National Engineering Laboratory (INEL) researchers. For the human trials, treatment planning and radiation dose estimation is performed using the BNCT-Rtpe and the rtt-MC computer codes developed by the INEL BNCT program. This paper discusses our initial experience using these treatment planning codes for human subjects. The basic principles of BNCT have been previously documented.

318

Targeted integration of baboon endogenous virus in the BEVI locus on human chromosome 6.

BackgroundUnderstanding the mechanisms that control rates of disease progression in humans and other species is an important area of research relevant to epidemiology and to translating...Full Text Available

319

Sequence features involved in the mechanism of 3' splice junction wobbling

The infection of cultured human cells with baboon endogenous virus (BEV) frequently leads to an association of viral DNA with a specific genetic locus (termed BEVI, for baboon endogenous virus infection) on chromosome 6. Restriction endonuclease digestion of DNA from BEV-infected human cells and their derived somatic cell clones frequently revealed a common cellular DNA sequence in the proximity of one of the junctions between cellular DNA and the integrated virus. We propose that a short cellular DNA sequence, repeated on chromosome 6 and separated by unique DNA sequences, presents a high-affinity target for the integration of BEV in human cells. PMID:6401843

1983-01-13

320

Selective changes of retroelement expression in human prostate cancer

BackgroundAlternative splicing is an important mechanism mediating the diversified functions of genes in multicellular organisms, and such event occurs in around 40-60% of human...Full Text Available

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

321

British Library Electronic Table of Contents (United Kingdom)

Retroelements constitute a large part of the human genome. These sequences are mostly silenced in normal cells, but genome-wide DNA hypomethylation in cancers might lead to their re-expression. Whether this re-expression really occurs in human cancers is largely unkown. We therefore investigated expression and DNA methylation of several classes of retroelements in human prostate cancer tissues and cell lines by quantitative reverse transcription-polymerase chain reaction and pyrosequencing, respectively. The most striking finding was strong and generalized increased expression of the HERV-K_22q11.23 provirus in cancers, including de novo expression of a spliced accessory Np9 transcript in some tumors. In parallel, DNA methylation in the long terminal repeat (LTR) decreased. Conversely, HER...

2011-01-01

322

Securing co-operation from persons supplying statistical data

Scanning Electron Microscopy of Sarcophagid (Diptera) Larvae Recovered from a Case of Human Cutaneous Myiasis

Securing the co-operation of persons supplying information required for medical statistics is essentially a problem in human relations, and an understanding of the motivations, attitudes, and behaviour...Full Text Available

1954-01-01

323

Role of spinal cyclooxygenase in human postoperative and chronic pain

... point dried and mounted on aluminum stubs using colloidal silver paste. Mounted specimens were observed and photographed using ... ...

324

Retinoids for Treatment of Retinal Diseases

BackgroundNonsteroidal anti-inflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest these drugs act in part by blocking...Full Text Available

2010-05-01

325

Regulatory T cells in human disease and their potential for therapeutic manipulation

Knowledge about retinal photoreceptor signal transduction and the visual cycle required for normal eyesight has expanded exponentially over the past decade. Substantial progress in human genetics...Full Text Available

2010-06-01

326

Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory...Full Text Available

2006-05-01

327

Ras history

Prenatal immunotoxicant exposure and postnatal autoimmune disease.

Although the roots of Ras sprouted from the rich history of retrovirus research, it was the discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an...Full Text Available

2010-07-01

328

Possible health effects of working with VDUs.

Reports in humans and rodents indicate that immune development may be altered following perinatal exposure to immunotoxic compounds, including chemotherapeutics, corticosteroids, polycyclic hydrocarbons,...Full Text Available

1999-10-01

329

Phylogenomic analyses of malaria parasites and evolution of their exported proteins

A summary of the effects presented here is given in the table. The designation "factor present" implies that there is knowledge (from human or animal studies, or both) of a specific factor(s) present...Full Text Available

1989-04-01

330

Panel warns of a crisis in american Physics

BackgroundPlasmodium falciparum is the most malignant agent of human malaria. It belongs to the taxon Laverania, which includes other ape-infecting Plasmodium...Full Text Available

331

CERN Multimedia

"Physics in America is at a crossroads and in crisis, just as humanity stands on the verge of great discoveries about the nature of matter and the universe, a panel from the National Academy of sciences concludes in a new report."

2006-01-01

332

PET imaging of tumour hypoxia

Neuroprotective Effects of Methanol Extracts of Jeju Native Plants on Hydrogen Peroxide-induced Cytotoxicity in SH-SY5Y Human Neuroblastoma Cells

Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive and...Full Text Available

333

Full Text Available

2007-10-01

334

Neurocysticercosis

NASA's Strategic Human Capital Implementation Plan - NASA Headquarters

A single enhancing lesion in the brain parenchyma, also called an inflammatory granuloma, is a frequent neurologic diagnosis. One of the commonest causes of this lesion is human neurocysticercosis,...Full Text Available

2010-08-17

335

o If retaining CSRS/FERS, transferred employee will be credited with accumulated sick leave o Be reimbursed for travel, transportation, relocation costs ...

336

NASA - Waste Not

Multifunctional, Boron-Foam Based Radiation Shielding

Jun 4, 2004 ... On a two-year trip to Mars, according to one estimate, a crew of six humans will generate more than six tons of solid organic waste--much of ...

337

Monthly electricity usage at Australian Antarctic Stations - NASA

PROPOSAL NUMBER: 04 B3.09-7744. SUBTOPIC TITLE: Radiation Shielding to Protect Humans. PROPOSAL TITLE: Multifunctional, Boron-Foam Based ...

338

Molecular cloning and analysis of lymphokines. Volume 13

Record Search Query: Science Keywords>HUMAN DIMENSIONS>INFRASTRUCTURE> ELECTRICITY. Monthly electricity usage at Australian Antarctic Stations ...

339

Molecular Genetics and Carcinogenesis Section

These proceedings collect papers on the subject of lymphokines. Topics include: DNA-cloning of mouse and human lymphokine genes, inteferons, interleukins, gene expression, tumor necrosis factors, and recombinant DNA.

1987-01-01

340

Molecular Characterization of Cryptosporidium Oocysts in Samples of Raw Surface Water and Wastewater

The Molecular Genetics and Carcinogenesis Section conducts studies using human epithelial cells to assess: activation of proto-oncogenes by chemical and physical carcinogens; inactivation and dysregulation of tumor suppressor genes by chemical and physical

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

341

Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units.

Recent molecular characterizations of Cryptosporidium parasites make it possible to differentiate the human-pathogenic Cryptosporidium parasites from those that do...Full Text Available

2001-03-01

342

Metals and kidney autoimmunity.

PMID:10684911

2000-02-24

343

Maternal deprivation stress as a risk factor for mental health: Neurotrophins as neuroendocrine signals in rodents and non-human primates

The causes of autoimmune responses leading to human kidney pathology remain unknown. However, environmental agents such as microorganisms and/or xenobiotics are good candidates for that role. Metals,...Full Text Available

1999-10-01

344

Magnetic resonance imaging in human lymphodemas

... for mediating the effects of early adverse experiences since they are affected

2008-10-01

345

Low cytotoxicity effect of dendrosome as an efficient carrier for rotavirus VP2 gene transferring into a human lung cell line

The MRI's of 16 patients with either primary or secondary lymphatic disorders are evluated and the findings are compared to those from lymphangioscintigraphy or surgery. (author).

1989-09-02

346

British Library Electronic Table of Contents (United Kingdom)

The efficiency of dendrosome (a gene porter) was assessed in transferring recombinant human rotavirus VP2 cDNA into A549, a human lung cell line. After gene transferring, transmission electron microscopy showed core-like particles (CLPs) formation in the transfected cells both with dendrosome and lipofectamine porters. In addition, western blotting analysis showed that the expression of VP2 gene was almost equal in the dendrosome and lipofectamine-transfected cells. Also, the cytotoxicity studies revealed that dendrosome had a lower cytotoxicity than lipofectamine. Therefore, our study may introduce dendrosome as a possible carrier for gene transferring into the human lung cell line, especially, for intranasally administration of DNA vaccines.

2009-01-01

347

Liver Carcinogenesis Unit

Lighting in indoor environments: Visual and non-visual effects of light sources with different spectral power distributions

The Liver Carcinogenesis Section uses the modern technologies of molecular biology, cell biology, protein chemistry and genetics to investigate the biochemical and genetic pathways involved in human liver cancer.

348

British Library Electronic Table of Contents (United Kingdom)

Since the end of the 1990s, good quality lighting was that which balanced the needs of humans, economic and environmental issues, and architectural design. Recent studies aimed to find a correlation between environmental lighting and human performance and health, with positive results. What is known, is that insufficient or inappropriate light exposure can disrupt standard human rhythms which may result in adverse consequences for performance, safety, health. By studying the relationship between human physiology and light, research in photobiology has advanced to the point where some attempts to foresee what the lighting practice will be in future. The question is if lighting practice and lighting practitioners are ready for changes. This paper has the aim of introducing the recent discove...

2011-01-01

349

Legionella Pneumophila Transcriptome during Intracellular Multiplication in Human Macrophages

Job Opportunities - Office Of Human Capital Management - NASA

Legionella pneumophila is the causative agent of Legionnaires’ disease, an acute pulmonary infection. L. pneumophila is able to infect and multiply in both...Full Text Available

350

Jeffrey W. McCandless: Computer Vision - NASA Vision Group

Jun 6, 2011 ... Sick leave is earned at a rate of 4 hours per pay period. ... The Federal Employees Retirement System (FERS) is a three-tiered pension plan ...

351

Isolation and differentiation of chondrocytic cells derived from human embryonic stem cells using dlk1/FA1 as a novel surface marker

Jeffrey W. McCandless is a post-doctoral researcher at NASA Ames Research Center in the Human Factors Research and Technology Division.

352

Interactive computer programs in sequence data analysis.

Udgivelsesdato: 2009-Dec

2009-01-01

353

In vitro atrazine-exposure inhibits human natural killer cell lytic granule release

We present interactive computer programs for the analysis of nucleic acid sequences. In order to handle these programs, minimum computer experience is sufficient. The nucleotide sequence of the human...Full Text Available

1982-01-11

354

British Library Electronic Table of Contents (United Kingdom)

The herbicide atrazine is a known immunotoxicant and an inhibitor of human natural killer (NK) cell lytic function. The precise changes in NK cell lytic function following atrazine exposure have not been fully elucidated. The current study identifies the point at which atrazine exerts its affect on the stepwise process of human NK cell-mediated lyses of the K562 target cell line. Using intracellular staining of human peripheral blood lymphocytes, it was determined that a 24-h in vitro exposure to atrazine did not decrease the level of NK cell lytic proteins granzyme A, granzyme B or perforin. Thus, it was hypothesized that atrazine exposure was inhibiting the ability of the NK cells to bind to the target cell and subsequently inhibit the release of lytic protein from the NK cell. To test t...

2007-01-01

355

In vitro activity and human pharmacokinetics of teicoplanin.

In Vitro Toxicity of Silver Nanoparticles in Human Lung ...

The in vitro activity of teicoplanin, a new antibiotic related to vancomycin, was determined against 456 gram-positive cocci. The activity of teicoplanin in comparison with that of vancomycin was similar...Full Text Available

1984-12-01

356

Immunology of schistosomiasis*

... The MTT assay indicates cell viability through a yellow to purple ... besiegers were said to have catapulted plague infected corpses into the city of ...

2009-03-01

357

Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma

This Memorandum, after summarizing the life cycle of the different species of human schistosome, reviews the present knowledge of the immunology of schistosomiasis. Each stage of the parasite contains...Full Text Available

1974-01-01

358

Human viral gastroenteritis.

Normal human foreskin keratinocytes cotransfected with the neomycin resistance gene and recombinant human papillomavirus (HPV) DNAs (types 16, 18, 31, and 33) that have a high or moderate association with cervical malignancy acquired immortality and contained integrated and transcriptionally active viral genomes. Only transcripts from the intact E6 and E7 genes were detected in at least one cell line, suggesting that one or both of these genes are responsible for immortalization. Recombinant HPV DNAs with low or no oncogenic potential for cervical cancer (HPV1a, -5, -6b, and -11) induced small G418-resistant colonies that senesced as did the nontransfected cells. These colonies contained only episomal virus DNA; therefore, integration of HPV sequences is important for immortalization of keratinocytes. This study suggests that the virus-encoded immortalization function contributes to the pathogenesis of cervical carcinoma.

1989-01-01

359

Human and rat mast cell high-affinity immunoglobulin E receptors: Characterization of putative. alpha. -chain gene products

During the last 15 years, several different groups of fastidious viruses that are responsible for a large proportion of acute viral gastroenteritis cases have been discovered by the electron microscopic...Full Text Available

1989-01-01

360

Human Interfaces for Robotic Satellite Servicing

The authors have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative {alpha} subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH{sub 2}-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hydrophobic transmembrane region, and a positively charged cytoplasmic tail. The human and rat {alpha} subunits share an overall homology with one another and the immunoglobulin gene family, suggesting that they arose from a common ancestral gene and continue to share structural homology with their ligands. In addition, the rat gene is transcribed into at least three distinct forms, each of which yields a somewhat different coding sequence.

1988-03-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Human Factors Assessment of the UH-60M Common Avionics ...

... of China Lake Naval Weapons Center, California. ... Figure 4: The Space-Based Laser cleaning ... of Aeronautics and Astronautics (AIAA) Space 2001 ...

2011-05-13

362

Homocysteine and Familial Longevity: The Leiden Longevity Study

... 1768 1475 360 to 3400 ... The TSC provided an independent assessment of SA based on ... Complexity of Situation Degree of complication (number of ...

2005-12-01

363

Healthy aging and disease: role for telomere biology?

Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor...Full Text Available

364

Health effects of indoor odorants.

Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease,...Full Text Available

2011-05-01

365

Health and environmental chemistry: Analytical techniques, data management, and quality assurance. Volume 1, Manual

People assess the quality of the air indoors primarily on the basis of its odors and on their perception of associated health risk. The major current contributors to indoor odorants are human occupant...Full Text Available

1991-11-01

366

Health Topics beginning with A - National Institutes of Health...

Analytical procedures are described for the determination of organic compounds, metals and radioisotopes in environmental materials, human tissues, urine, feces, and waste water.

1993-11-01

367

Skip Over Navigation Links U.S. Department of Health & Human Services National Institutes of Health NIH...Turning Discovery into Health For Employees Staff Directory En Español...

2011-08-26

368

Health Concerns in Haiti

HDL in humans with cardiovascular disease exhibits a proteomic signature

Issues Democracy and Human Rights Economic Issues Energy Security Food Security Haiti Health Iran Iraq Landmines Middle East Muslim Outreach Narcotics Nonproliferation North Korea...

2011-08-28

369

BackgroundAlterations in protein composition and oxidative damage of high-density lipoprotein (HDL) have been proposed to impair the cardioprotective properties of...Full Text Available

2010-07-04

370

Going beyond panaceas

Genomics of human longevity

In the context of governance of human–environment interactions, a panacea refers to a blueprint for a single type of governance system (e.g., government ownership, privatization, community property)...Full Text Available

2007-09-25

371

Functionally defined substates within the human embryonic stem cell compartment.

In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences...Full Text Available

2011-01-12

372

Fluence- and exposure-to-dose conversion for human whole-body gamma irradiation

Human embryonic stem (ES) cells can undergo spontaneously differentiation in standard culture conditions, demonstrating that the undifferentiated state is relatively unstable. The heterogeneous expression of SSEA3 observed within human ES colonies, provides a means to examine undifferentiated stem cell substates. Through functional testing of single cells we have shown that undifferentiated ES cells can be segregated into functionally discrete subpopulations on the basis of SSEA3 expression: SSEA3(High), SSEA(Low) and SSEA3(Negative). Human ES subpopulations were found to be interconvertible, but they possess distinct properties when challenged to differentiate along the neural lineage. These data suggest that ES cells with pluripotent/self-renewal capacities can exhibit different responses to induction of differentiation. PMID:21763622

2011-05-11

373

Evaluation of phenylpiperazines as targeting agents for neuroblastoma.

... kev range 10-100 kev range 100-1000 man mev range 01-10 personnel

1978-01-01

374

Estimation of Human Toxicity From Animal Inhalation Toxicity ...

The potential of radiolabelled phenylpiperazines as agents for the detection and therapy of tumours of neural crest origin was evaluated by in vitro pharmacological studies with human neuroblastoma...Full Text Available

1996-09-01

375

Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types

... Bisgard, GE, Ruiz, AV, Grover, RF & Will, JA, "Ventilatory control in the ... Watkins, BE, Riegle, GD & Heisey, SR, "Respiratory responses to ACTH and ...

1997-10-01

376

Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis

Udgivelsesdato: 2009-Jun

2009-01-01

377

Effector Glycosyltransferases in Legionella

The rapidly emerging science of epigenetics and epigenomic medicine promises to reveal novel insights into the susceptibility to and the onset and progression of epileptic disorders. Epigenetic...Full Text Available

2010-07-01

378

Effect of Registration on Cyclical Kinematic Data

Legionella causes severe pneumonia in humans. The pathogen produces an array of effectors, which interfere with host cell functions. Among them are the glucosyltransferases Lgt1, Lgt2...Full Text Available

379

Differential immunotoxic effects of inorganic and organic mercury species in vitro

Given growing interest in Functional Data Analysis (FDA) as a useful method for analyzing human movement data, it is critical to understand the effects of standard FDA procedures, including...Full Text Available

2010-08-26

380

British Library Electronic Table of Contents (United Kingdom)

Despite the fact that humans are exposed to multiple forms of mercury (elemental, inorganic, and organic), most research on mercury toxicity has focused on methylmercury (MeHg) and on neurotoxic outcomes and mechanisms. Recent work has indicated that the immunotoxic effects of mercury compounds may be significant contributors to human disease as well as mechanistically relevant to other target organ toxicities. In this study, we compared the effects of inorganic Hg (iHg) to organic Hg species (MeHg and ethylmercury, EtHg) in human peripheral blood mononuclear cells (PBMCs) in vitro at sub-cytotoxic concentrations, using methods developed to characterize response of human PBMCs to iHg in vitro. PBMCs were isolated from six volunteer blood donors (three males and three females) and cultured ...

2010-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

381

Developmentally programmed endoreduplication in animals

Development of a microarray for identification of pathogenic Clostridium species

Development of a fertilized egg into an adult human requires trillions of cell divisions, the vast majority of which duplicate their genome once and only once. Nevertheless, trophoblast giant...Full Text Available

2009-05-15

382

Developing defined culture systems for human pluripotent stem cells

In recent years, Clostridium species have rapidly reemerged as human and animal pathogens. The detection and identification of pathogenic Clostridium species...Full Text Available

2010-02-01

383

British Library Electronic Table of Contents (United Kingdom)

Human pluripotent stem cells hold promising potential in many therapeutics applications including regenerative medicine and drug discovery. Over the past three decades, embryonic stem cell research has illustrated that embryonic stem cells possess two important and distinct properties: the ability to continuously self-renew and the ability to differentiate into all specialized cell types. In this article, we will discuss the continuing evolution of human pluripotent stem cell culture by examining requirements needed for the maintenance of self-renewal in vitro. We will also elaborate on the future direction of the field toward generating a robust and completely defined culture system, which has brought forth collaborations amongst biologists and engineers. As human pluripotent stem cell re...

2011-01-01

384

Detection of genetic mutations in repetitive DNA sequences in somatic human cells after low-dose irradiation

Depleted uranium human health risk assessment, Jefferson Proving Ground, Indiana

... 3-89701-147-6 0949-2224 245 p. animal cells dna genetic radiation effects

1998-03-01

385

Deforestation Plays Critical Climate Change Role - NASA Earth ...

The risk to human health from fragments of depleted uranium (DU) at Jefferson Proving Ground (JPG) was estimated using two types of ecosystem pathway models. A steady-state, model of the JPG area was developed to examine the effects of DU in soils, water, and vegetation on deer that were hunted and consumed by humans. The RESRAD code was also used to estimate the effects of farming the impact area and consuming the products derived from the farm. The steady-state model showed that minimal doses to humans are expected from consumption of deer that inhabit the impact area. Median values for doses to humans range from about 1 mrem ({plus_minus}2.4) to 0.04 mrem ({plus_minus}0.13) and translate to less than 1 {times} 10{sup {minus}6} detriments (excess cancers) in the population. Monte Carlo simulation of the steady-state model was used to derive the probability distributions from which the median values ...

1994-04-29

386

Current Projects - Human Nutrition Research Center on Aging ...

May 11, 2007 ... "Deforestation in the tropics accounts for nearly 20 per cent of carbon emissions due to human activities," Dr. Canadell says. ...

387

Cuba's response to the HIV epidemic.

diet and genetic obesity metabolic defects and inflammation. To determine the role of adipocyte death in promoting adipose tissue inflammation and insulin resistance in animal...

2011-08-31

388

Continuous human cell lines and method of making same

BACKGROUND: Cuba's response to the human immunodeficiency virus (HIV) epidemic has been to conduct mass testing of the population to ascertain seroprevalence, to enforce mandatory relative quarantine...Full Text Available

1991-05-01

389

Comparison of internal emitter radiobiology in animals and humans

Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo(a)pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors. 2 tabs.

1985-07-01

390

Cloning of the cDNA for the human. beta. /sub 1/-adrenergic receptor

Investigations of radionuclide metabolism and effects in various mammalian species revealed important similarities between animals and humans and between some animal species. These include skeletal deposition of radium and radiostrontium in bone volume; deposition on bone surfaces of plutonium and other actinides; liver deposition of actinides; induction of skeletal or liver malignancies by these radionuclides; induction of tooth and jaw abnormalities; mammary cancer induction by radium in humans and in the beagle; depression of circulating cells in blood; and induction of bone fractures. There are also inter-species differences that may not have been noted if multiple species (including humans) had not been studied. Some of these are more rapid excretion of radium in humans compared with most other mammals; induction by radium of eye melanomas in animals but not humans; rapid loss ...

1997-01-01

391

Clinical significance of coagulase-negative staphylococci.

Screening of a human placenta lambdagt11 library has led to the isolation of the cDNA for the human ..beta../sub 1/-adrenergic receptor (..beta../sub 1/AR). Used as the probe was the human genomic clone termed G-21. This clone, which contains an intronless gene for a putative receptor, was previously isolated by virtue of its cross hybridization with the human ..beta../sub 2/-adrenergic receptor (..beta../sub 2/AR). The 2.4-kilobase cDNA for the human ..beta../sub 1/AR encodes a protein of 477 amino acid residues that is 69% homologous with the avian ..beta..AR but only 54% homologous with the human ..beta../sub 2/AR. This suggests that the avian gene encoding ..beta..AR and the human gene encoding ..beta../sub 1/AR evolved from a common ancestral gene. RNA blot analysis indicates a message of 2.5 kilobases in rat tissues, with a pattern of ...

1987-11-01

392

Cis-regulatory mutations in human disease

Although coagulase-negative staphylococci (C-NS) have been implicated in certain human infections, they are generally regarded as contaminants, and their clinical significance is questioned. To assess...Full Text Available

1982-08-01

393

Chromosomal localization and structure of the human type II IMP dehydrogenase gene

Cis-acting regulatory sequences are required for the proper temporal and spatial control of gene expression. Variation in gene expression is highly heritable and a significant determinant...Full Text Available

2009-07-01

394

Cholinesterase for Prophylactics of Poisoning by Organophosphorous Inhibitors

We determined the chromosomal localization and structure of the gene encoding human type II inosine 5{prime}-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205), an enzyme associated with cellular proliferation, malignant transformation, and differentiation. Using polymerase chain reaction (PCR) primers specific for type II IMPDH, we screened a panel of human-Chinese hamster cell somatic hybrids and a separate deletion panel of chromosome 3 hybrids and localized the gene to 3p21.1{yields}p24.2. Two overlapping yeast artificial chromosome clones containing the full gene for type II IMPDH were isolated and a physical map of 117 kb of human genomic DNA in this region of chromosome 3 was constructed. The gene for type II IMPDH was localized and oriented on this map and found to span no more than 12.5 kb.

1994-05-01

395

International Science & Technology Center (ISTC)

The Production of Highly Active Human Blood Plasma Butyrylcholinesterase Preparation by Gene Engineering Methods to Create Protective Means against Poisoning by Organophosphorous Cholinesterase Inhibitors

396

Cellular and molecular response of human macrophages exposed to Aggregatibacter actinomycetemcomitans leukotoxin

Cancer gene discovery in mouse and man

Aggregatibacter (Actinobacillus) actinomycetemcomitans is a facultative anaerobic gram-negative bacterium associated with severe forms of periodontitis. A leukotoxin, which belongs...Full Text Available

2011-03-01

397

Building the Perfect Parasite: Cell Division in Apicomplexa

AbstractThe elucidation of the human and mouse genome sequence and developments in high-throughput genome analysis, and in computational tools, have made it possible to profile entire...Full Text Available

2009-12-01

398

Biology of Pseudomonas stutzeri

Apicomplexans are pathogens responsible for malaria, toxoplasmosis, and crytposporidiosis in humans, and a wide range of livestock diseases. These unicellular eukaryotes are stealthy invaders, sheltering...Full Text Available

2007-06-01

399

Biological and morphological characterization of human neonatal fibroblast cell culture B-HNF-1

Pseudomonas stutzeri is a nonfluorescent denitrifying bacterium widely distributed in the environment, and it has also been isolated as an opportunistic pathogen from humans. Over the...Full Text Available

2006-06-01

400

British Library Electronic Table of Contents (United Kingdom)

In the present study, human neonatal fibroblasts were isolated from a two-month-old human male. The purpose of the present investigation was the analysis of the morphology (light and transmission electron microscopy), karyotype and growth characteristics of the human neonatal fibroblast cell culture B-HNF-1. Moreover, STR typing and mitochondrial DNA amplification and sequencing was also performed. Analysis of chromosomes count showed that B-HNF-1 cell culture is diploid and has normal male karyotype 46, XY, which was stable during cultivation. The transmission electron microscopy demonstrated the ultra-structure of the B-HNF-1 cells; they have typical morphological features of proteosynthesis-active cells. Large number of fibroblasts bearing different shapes and surface characteristics ad...

2010-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

401

Battle Management Command and Control (BMC2) Human ...

Avoidance of hydrolyzed casein by mice

... For communication systems that employ spatial audio technology to separate intercom and/or radio channels, configurations of the spatial ...

2005-06-01

402

Augustine panel visits Huntsville to discuss future of human ...

When casein, a milk protein, is hydrolyzed, it renders human foods that contain it (e.g., hypoallergenic infant formula, cheeses) distasteful to many people. This rejection...Full Text Available

2008-01-28

403

Arrival ... - Human Factors Research and Technology Division - NASA

Aug 6, 2009 ... be cleaned with common household disinfectants regularly and after increased crowd contact. Marshall's Emergency Operations Center and the ...

404

Are animal models predictive for humans?

airborne separation assistance systems (ASAS) to ... operations should be limited to the outer traffic flow ...... AGARD Meeting on Machine Intelligence in Air ...

405

Analysis of codon usage and nucleotide composition bias in polioviruses

It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific...Full Text Available

406

Aging in Language Dynamics

BackgroundPoliovirus, the causative agent of poliomyelitis, is a human enterovirus and a member of the family of Picornaviridae and among the most rapidly evolving viruses known....Full Text Available

407

Adhesion of Vibrio cholerae to Granular Starches

Human languages evolve continuously, and a puzzling problem is how to reconcile the apparent robustness of most of the deep linguistic structures we use with the evidence that they undergo possibly...Full Text Available

408

AIR ... - Human Factors Research and Technology Division - NASA

Cholera is a severe diarrheal disease caused by specific serogroups of Vibrio cholerae that are pathogenic to humans. Cholera can become epidemic and deadly without adequate medical...Full Text Available

2005-08-01

409

A continuum model of protrusion of pseudopod in leukocytes.

TRACON controller, traffic flow manager, or pilot. .... separation violations to individual controller and ..... System, AGARD Meeting on Machine Intelligence ...

410

A Human-Centered Design and Evaluation Framework for Information Search

The morphology of human leukocytes, the biochemistry of actin polymerization, and the theory of continuum mechanics are used to model the pseudopod protrusion process of leukocytes. In the proposed...Full Text Available

1988-12-01

411

Design of High-speed Wear Lifetime Tester of the Instrument Ball Bearings

Information search in a distributed environment is an interactive process between the user and the artifact. How the information is distributed across the user and the artifact determines the efficacy...Full Text Available

2005-01-01

412

Variations in humanized and defined culture conditions supporting derivation of new human embryonic stem cell lines

The instrument ball bearings are the key components of movable components for various kinds of measuring and control instruments; they often operate in the environmental condition of high-speed and light preload. In general, the non metal, disposable oilimpregnated retainer material has been used for these kinds of high precision miniature bearing. The engineering practice shows that the common failure mode of them is the wear which appears under the condition of insufficient lubrication condition. As the results, the vibration and noise will be enlarged, so does the frictional torque, which makes the ball bearings to lose its original working accuracy. It is the lifetime test of bearings that can enable the designers and manufacturers to chose the material of the bearing properly, optimize the product structure, mend the manufacturing technique process, and to enhance the technical level of the bearing products significantly. In this paper, the wear lifetime tester has been designed ...

2006-10-15

413

Unusual heterogeneity of the 5'-termini of human adenovirus type 2 early region E2 mRNA.

The evolution of "humanized" (i.e., free of animal sourced reagents) and ultimately chemically defined culture systems for human embryo stem cell (hESC) isolation and culture is of importance to improving their efficacy and safety in research and therapeutic applications. This can be achieved by integration of a multitude of individual approaches to replace or eliminate specific animal sourced reagents into a single comprehensive protocol. In the present study our objective was to integrate strategies obviating reliance on some of the most poorly defined and path-critical factors associated with hESC derivation, namely the use of animal immune compliment to isolate embryo inner cell mass, and animal sourced serum products and feeder cells to sustain hESC growth and attachment. As a result we report the derivation of six new hESC lines isolated by outgrowth from whole blastocysts on an extracellular matrix substrate of purified ...

2006-01-01

414

Trefoil Factor 3 Is Oncogenic and Mediates Anti-Estrogen Resistance in Human Mammary Carcinoma123

The 5'-terminal structures of human adenovirus type 2 (Ad2) early region 2 (E2) mRNA were investigated. The E2 transcription unit has several interesting properties, including the presence of a TATA-like...Full Text Available

1984-12-11

415

Transfer of Plasmid-Mediated CTX-M-9 from Salmonella enterica Serotype Virchow to Enterobacteriaceae in Human Flora-Associated Rats Treated with Cefixime?

We report herein that trefoil factor 3 (TFF3) is oncogenic and mediates anti-estrogen resistance in human mammary carcinoma. Forced expression of TFF3 in mammary carcinoma cells increased cell proliferation...Full Text Available

2010-12-01

416

The mitogenic activity of human T-cell leukemia virus type I is T-cell associated and requires the CD2/LFA-3 activation pathway.

Food animals are a potential source of CTX-M resistance genes for humans. We evaluated the transfer of the bla_CTX-M-9 gene from an animal strain of Salmonella enterica...Full Text Available

2010-01-01

417

The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: evidence for multiple mRNA species.

The presence of a high number of activated T cells in the bloodstream and spontaneous proliferation of peripheral blood mononuclear cells in vitro are striking characteristics of human T-cell leukemia...Full Text Available

1993-06-01

418

The Membrane Bound LRR Lipoprotein Slr, and the Cell Wall-Anchored M1 Protein from Streptococcus pyogenes Both Interact with Type I Collagen

A recombinant M13 clone (O42) containing a 65 b.p. cDNA fragment from human fetal liver mRNA coding for glyceraldehyde-3-phosphate dehydrogenase has been identified and it has been used to isolate from...Full Text Available

1984-12-11

419

The Effect of Circumcision of HIV-Infected Men on Human Papillomavirus Infection in Female Partners: Analyses Using Data from a Randomized Trial in Rakai, Uganda

Streptococcus pyogenes is an important human pathogen and surface structures allow it to adhere to, colonize and invade the human host. Proteins containing leucine rich repeats (LRR)...Full Text Available

420

The Changing Face of Pediatric Respiratory Tract Infections: How Human Metapneumovirus and Human Bocavirus Fit into the Overall Etiology of Respiratory Tract Infections in Young Children

BackgroundMale circumcision (MC) reduces high-risk human papillomavirus (HR-HPV) in HIV-uninfected men and their female partners. We assessed whether MC of HIV-infected...Full Text Available

2011-08-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

421

TGFB1-Induced Extracellular Expression of TGFBIp and Inhibition of TGFBIp Expression by RNA Interference in a Human Corneal Epithelial Cell Line

Lower respiratory tract infections are one of the leading causes of morbidity and mortality in children worldwide. Recent technological advances in the field of molecular biology have allowed virologists...Full Text Available

2010-12-01

422

Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin

Purpose.To report the increased production of extracellular transforming growth factor β-induced protein (TGFBIp) by human corneal epithelial cells (HCECs) after induction...Full Text Available

2011-02-01

423

Structural Chemistry of Human SET Domain Protein Methyltransferases

Human serum albumin (HSA) has two primary binding sites for drug molecules. These sites selectively bind different dansylated amino acid compounds, which—due to their intrinsic fluorescence—have...Full Text Available

2011-04-01

424

Simultaneous Detection of Multiplex-Amplified Human Immunodeficiency Virus Type 1 RNA, Hepatitis C Virus RNA, and Hepatitis B Virus DNA Using a Flow Cytometer Microsphere-Based Hybridization Assay

There are about fifty SET domain protein methyltransferases (PMTs) in the human genome, that transfer a methyl group from S-adenosyl-L-methionine (SAM) to substrate lysines on histone tails or other peptides. A number of structures in complex with cofactor, substrate, or inhibitors revealed the mechanisms of substrate recognition, methylation state specificity, and chemical inhibition. Based on these structures, we review the structural chemistry of SET domain PMTs, and propose general concepts towards the development of selective inhibitors.

2011-08-22

425

Shorter anogenital distance predicts poorer semen quality in young men in Rochester, New York

The feasibility of performing a multiplex assay for the detection of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) RNAs and hepatitis B virus (HBV) DNA is demonstrated. This...Full Text Available

2000-03-01

426

Ribose metabolism and nucleic acid synthesis in normal and glucose-6-phosphate dehydrogenase-deficient human erythrocytes infected with Plasmodium falciparum.

In male rodents, anogenital distance (AGD) provides a sensitive and continuous correlate of androgen exposure in the intrauterine environment and predicts later reproductive success. Some endocrine-disrupting chemicals can alter male reproductive tract development, including shortening AGD, in both rodents and humans. Whether AGD is related to semen quality in human is unknown.

2011-01-01

427

Removal of uv-induced pyrimidine dimers from the replicated and unreplicated DNA of human fibroblasts

The metabolism of pentose-phosphate was investigated in Plasmodium falciparum-infected normal and glucose-6-phosphate dehydrogenase (G6PD)-deficient human red blood cells in vitro. 5'-Phosphoribosyl-1-pyrophosphate...Full Text Available

1986-04-01

428

Proteasome Inhibition in Human Breast Cancer Cells with High Catechol-O-methyltransferase Activity by Green tea polyphenol EGCG analogs

Excision repair in uv irradiated human fibroblasts has been examined in portions of DNA replicating after irradiation versus those remaining unreplicated. Two approaches, one using a uv-endonuclease to estimate pyrimidine dimers remaining in DNA, the other using density labeling to measure excision resynthesis, indicate that the extent of repair is the same for both replicated and unreplicated DNA.

1978-01-01

429

Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens.

A pro-drug 8 of a synthetic analog 7 is more active in its anti-proliferative activity against human breast cancer MDA-MB-231 cells possessing high Catechol-O-methyltransferase...Full Text Available

2010-02-01

430

Presence of antibodies to a putatively immunosuppressive part of human immunodeficiency virus (HIV) envelope glycoprotein gp41 is strongly associated with health among HIV-positive subjects.

Two monoclonal antibodies, TAL-1B5 and TAL-3C3, specific for human Ia alpha-chain subunits have been produced by fusing P3/NSI/1-Ag4-1 mouse myeloma cells with spleen cells from a BALB/c mouse immunized...Full Text Available

1983-12-01

431

Potent immune responses and in vitro pro-inflammatory cytokine suppression by a novel adenovirus vaccine vector based on rare human serotype 28

The IgG response to gp41 (envelope glycoprotein of Mr 41,000) of the human immunodeficiency virus (HIV) was studied with eight synthetic peptides derived from three different regions of the protein....Full Text Available

1988-07-01

432

Phosphorylation of ?6-Tubulin by Protein Kinase C? Activates Motility of Human Breast Cells*

Adenovirus vaccine vectors derived from rare human serotypes have been shown to be less potent than serotype 5 (Ad5) at inducing immune responses to encoded antigens. To identify highly immunogenic...Full Text Available

2010-08-09

433

Mastering a mediator: blockade of CCN-2 shows early promise in human diabetic kidney disease

Engineered overexpression of protein kinase Cα (PKCα) was previously shown to endow nonmotile MCF-10A human breast cells with aggressive motility. A traceable mutant of PKCα...Full Text Available

2009-06-26

434

NAME=\\

Wastenet

... All rickettsial diseases respond to treatment with antibiotics such as doxycycline and tetracycline As of 10 May, the Government of South Africa has reported 186 confirmed cases of RVF in humans, including 18 deaths, in Free State Province, Eastern Cape Province, Northern Cape Province, Western Cape, and North West Province. RVF is a viral disease that primarily affects animals (such as cattle, buffalo, sheep, goats and camels). The disease can also affect humans. The main mode of transmission of RVF ...

435

British Library Electronic Table of Contents (United Kingdom)

In diabetes complications, CCN-2 (known originally as CTGF) has been implicated in diabetic nephropathy both as a marker and a mediator of disease. This commentary addresses CCN-2 in diabetic nephropathy, in the context of the recent publication of the first human study to inhibit CCN-2 bioactivity in diabetic kidney disease.

2010-01-01

436

Localization of an anti-tumour monoclonal antibody in human tumour xenografts: kinetic and quantitative studies with the 791T/36 antibody

Localization of 131I-labeled p97-specific Fab fragments in human melanoma as a basis for radiotherapy.

Studies have been performed with an anti-osteogenic sarcoma monoclonal antibody 791T/36 and human tumour xenografts to examine some of the quantitative and kinetic aspects of tumour localization. The influence of variations in tumour size and site and antibody dose on the extent and rate of specific antibody localization have been examined, together with the site of intratumoural deposition of the antibody. (UK).

437

Limiting-dilution analysis of T cells extracted from solid human lung tissue: comparison of precursor frequencies for proliferative responses and lymphokine production between lung and blood T cells from individual donors.

33 patients with advanced malignant melanoma were studied after intravenous administration of 131I-labeled Fab fragments specific for p97, an oncofetal glycoprotein of human melanoma. In all, 47 gamma...Full Text Available

1983-12-01

438

Kinetics of the urea-induced dissociation of human plasma alpha 2-macroglobulin as measured by small-angle neutron scattering.

This study evaluates the frequency and functions of immunocompetent T cells at the clonal level in solid human lung tissue versus peripheral blood. Enzymatic digestion of slices of histologically normal...Full Text Available

1988-08-01

439

Isomeric prostaglandin F2 compounds arising from prostaglandin D2: a family of icosanoids produced in vivo in humans.

The kinetics of the urea-induced dissociation of human plasma alpha 2-macroglobulin into two half-molecular fragments was investigated at 21.0 degrees C by using small-angle neutron scattering. The...Full Text Available

1991-09-01

440

Isolation and characterization of cDNA clones for human skeletal muscle alpha actin.

Prostaglandin (PG) D2 has been shown to be transformed by human 11-ketoreductase to 9 alpha,11 beta-PGF2, a biologically active metabolite that is produced in vivo. During the course of developing a...Full Text Available

1988-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

441

Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes

Two cDNA libraries corresponding to polyA+ RNA from human adult skeletal muscle have been constructed by cloning in the PstI site of pBR322. Skeletal alpha actin cDNA clones have been isolated and characterized....Full Text Available

1983-06-11

442

Interaction of ?_V?₃ and ?_V?₆ Integrins with Human Parechovirus 1?

Despite intensive efforts, the intracellular signaling pathways that mediate apoptosis remain unclear. The human B lymphoma cell line, B104, possesses characteristics that make it an attractive model...Full Text Available

1996-11-26

443

Integrated Risk Framework for Gigawatt-Scale Deployments of Renewable Energy: The U.S. Wind Energy Case; October 2009

Human parechovirus (HPEV) infections are very common in early childhood and can be severe in neonates. It has been shown that integrins are important for cellular infectivity of HPEV1 through experiments...Full Text Available

2010-09-01

444

Insecticide Treated Camouflage Sceening Reduces Sand Fly Numbers in Leishmania-Endemic Regions in Kenya

Assessing the potential environmental and human effects of deploying renewable energy on private and public lands, along our coasts, on the Outer Continental Shelf (OCS), and in the Great Lakes requires a new way of evaluating potential environmental and human impacts. The author argues that deployment of renewables requires a framework risk paradigm that underpins effective future siting decisions and public policies.

2010-04-01

445

Incorporation of "1"4C-linoleic acid in cerebrosides of psoriatic and normal human skin

Current U.S. military operations in deserts face persistent threats from sand flies that transmit human Leishmania. In this study we investigated the efficacy of artificial barriers treated with residual insecticide to potentially reduce the risk of human infection from leishmaniasis by reducing the...

446

Human rib bone marrow mononuclear cells spontaneously synthesize and secrete IgE in vitro.

It was shown that the incorporation of "1"4C-linoleic acid in cerebrosides of normal and psoriatic human skin is different. In psoriatic epidermis and corium the turnover of this fatty acid is significantly elevated. It is suggested that in psoriasis the epidermal cell is not able to build up a regular carbohydrate sequences of lipids because the false carbohydrate chain activates the degradation of glycolipids and in compensating for the increased degradation raises the synthesis rate of glycolipids. (orig./MG).

447

Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec

We have examined spontaneous secretion of IgE by human rib bone marrow mononuclear cells (MNC). Bone marrow MNC from nine out of 12 rib specimens synthesized and secreted substantial amounts of IgE...Full Text Available

1991-01-01

448

Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy

BackgroundThe human endogenous retrovirus HERV-K(HML-2) family is associated with testicular germ cell tumors (GCT). Various HML-2 proviruses encode viral proteins such as Env and...Full Text Available

449

Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing

IntroductionThe phenotypic and functional differences between cells that initiate human breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to...Full Text Available

2008-01-01

450

Hair shaft elongation, follicle growth, and spontaneous regression in long-term, gelatin sponge-supported histoculture of human scalp skin.

BackgroundThe beta-defensin gene cluster (DEFB) at chromosome 8p23.1 is one of the most copy number (CN) variable regions of the human genome. Whereas individual DEFB CNs have been...Full Text Available

451

Glutamine-linked and Non-consensus Asparagine-linked Oligosaccharides Present in Human Recombinant Antibodies Define Novel Protein Glycosylation Motifs

In order to better understand the molecular mechanisms of human hair growth control and to test hair growth-modulatory drugs, appropriate in vitro models are required. Here, we report the long-term...Full Text Available

1992-09-15

452

Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene.

We report the presence of oligosaccharide structures on a glutamine residue present in the V_L domain sequence of a recombinant human IgG2 molecule. Residue Gln-106, present in the QGT sequence...Full Text Available

2010-05-21

453

Genome-Wide Association Study SNPs in the Human Genome Diversity Project Populations: Does Selection Affect Unlinked SNPs with Shared Trait Associations?

We have isolated the human prointerleukin 1 (proIL-1) beta gene from leukocyte and fetal liver libraries. The nucleotide sequence and its gene organization reveals that the proIL-1 beta gene is composed...Full Text Available

1986-10-24

454

Fatty acid distribution in systems modeling the normal and diabetic human circulation. A 13C nuclear magnetic resonance study.

Genome-wide association studies (GWAS) have identified more than 2,000 trait-SNP associations, and the number continues to increase. GWAS have focused on traits with potential consequences for human...Full Text Available

2011-01-01

455

Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers.

A nonperturbing 13C nuclear magnetic resonance (NMR) method was used to monitor the equilibrium distribution of carboxyl 13C-enriched fatty acids (FA) between distinct binding sites on human serum albumin,...Full Text Available

1991-04-01

456

Ethical Issues in Human Stem Cell Research. Executive Summary, Volume 1: Report and Recommendations of the National Bioethics Advisory Commision, Volume 2: Commissioned Papers, and Volume 3: Religious Perspectives.

Although human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL), the role of viral gene expression in the progression to and maintenance of the...Full Text Available

1992-04-01

457

Establishment and Maintenance of Human Embryonic Stem Cell Lines on Human Feeder Cells Derived from Uterine Endometrium ...

In November 1998, President Clinton charged the National Bioethics Advisory Commission with the task of conducting a thorough review of the issues associated with human stem cell research, balancing all ethical and medical considerations. The President's ...

2000-01-01

458

Enhanced anti-tumor effects of combined MDR1 RNA interference and human sodium/iodide symporter (NIS) radioiodine gene therapy using an adenoviral system in a colon cancer model

... and pathogen transmission. Because the ultimate object of stem cell research is cell-based clinical therapy, hES cells should ... 4%) Supported by grants (SC12021 and SC11012) from Stem Cell Research...

459

Effects of the cannabinoid antagonist SR141716 (rimonabant) and d-amphetamine on palatable food and food pellet intake in non-human primates

Using an adenoviral system as a delivery mediator of therapeutic gene, we investigated the therapeutic effects of the use of combined MDR1 shRNA and human NIS (hNIS)...Full Text Available

2010-07-01

460

Effects of electromagnetic pollution on human health discussed

The purpose of this study was to determine if a cannabinoid CB₁ receptor antagonist would selectively decrease consumption of highly palatable food in non-human primates. The CB₁...Full Text Available

2007-04-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

461

Dimethoxycurcumin, a Structural Analogue of Curcumin, Induces Apoptosis in Human Renal Carcinoma Caki Cells Through the Production of Reactive Oxygen Species, the Release of Cytochrome c, and the Activation of Caspase-3

The harmful effects of high-intensity electric fields on human beings are discussed. Formulas for determining the field strength of high voltage transmission lines and track lines and experimental data of these effects on mice are given. Protective measures from these hazards are introduced. 18 references, 7 figures, 5 tables.

1982-01-01

462

Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation.

PurposeCurcumin (Cur) has been reported to induce apoptosis in human renal carcinoma Caki cells. Dimethoxycurcumin (DMC), one of several synthetic Cur analogues, has been reported...Full Text Available

2010-12-01

463

Dermatan sulphate and mucin glycopeptides from the human uterine cervix

Human Fas/Apo-1 is a cell-surface protein that mediates apoptosis upon ligation with Fas ligand. The gene lies on the long arm of chromosome 10, consists of nine exons, and spans more than 26 kb of...Full Text Available

1995-09-15

464

Deficiency in trefoil factor 1 (TFF1) increases tumorigenicity of human breast cancer cells and mammary tumor development in TFF1-knockout mice

High molecular weight glycopeptides and glycosaminoglycans were isolated from the human uterine cervix. The major part of the material (82%) was derived from cervical mucins. The remainder contained hyaluronic acid (3%), heparan sulphate (2%) and dermatan sulphate (13%). Chondroitin sulphate and keratan sulphate were not present, but chondroitin sulphate-like segments were included in the dermatan sulphate. The composition of the cervix apart from the mucus-filled crypts is similar to that of other fibrous connective tissues.

1983-01-01

465

Although trefoil factor 1 (TFF1; previously named pS2) is abnormally expressed in about 50% of human breast tumors, its physiopathological role in this disease has been poorly studied. Moreover,...Full Text Available

2011-07-21

466

DNA repair genes

Contraction-mediated inactivation of glycogen synthase is accompanied by inactivation of glycogen synthase phosphatase in human skeletal muscle.

Fission yeast S. pombe is assumed to be a good model for cloning of human DNA repair genes, because human gene is normally expressed in S. pombe and has a very similar protein sequence to yeast protein. We have tried to elucidate the DNA repair mechanisms of S. pombe as a model system for those of mammals. (J.P.N.)

1995-12-01

467

Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study

Activities of glycogen synthase (GS) and GS phosphatase were determined on human muscle biopsies before and after isometric contraction at 2/3 maximal voluntary force. Total GS activity did not change...Full Text Available

1989-05-01

468

Comparison of Human Serum Dopamine-?-Hydroxylase Levels by Radioimmunoassay and Enzymatic Assay

BackgroundHuman papillomavirus (HPV) infection is a major risk factor for the development of nearly all cases of cervical cancer worldwide. The presence of HPV DNA in cases of esophageal...Full Text Available

469

Cloning and characterization of a 77-kDa oestrogen receptor isolated from a human breast cancer cell line.

Human serum dopamine-β-hydroxylase (3,4-dihydroxyphenylethylamine, ascorbate:oxygen oxidoreductase, EC 1.14.17.1) has been measured in a normal adult population by both enzymatic assay and by...Full Text Available

1974-03-01

470

Astrocytes derived from trisomic human embryonic stem cells express markers of astrocytic cancer cells and premalignant stem-like progenitors

We have cloned and characterized a 77-kDa oestrogen receptor (ER) from an oestrogen-independent subclone of the MCF-7 human breast cancer cell line. This receptor contains an in-frame, tandem duplication...Full Text Available

1997-01-01

471

Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial.

BackgroundTrisomic variants of human embryonic stem cells (hESCs) arise spontaneously in culture. Although trisomic hESCs share many properties with diploid hESCs, they also exhibit...Full Text Available

472

Amino-Terminal Region of the Human Immunodeficiency Virus Type 1 Nucleocapsid Is Required for Human APOBEC3G Packaging

After baseline studies, 21 patients with osteoporosis were treated with human parathyroid hormone fragment (PTH 1-34) given as once-daily subcutaneous injections for 6-24 months. The dose used did not...Full Text Available

1980-06-07

473

Alterations in Adenylate Kinase Activity in Human PBMCs after In Vitro Exposure to Electromagnetic Field: Comparison between Extremely Low Frequency Electromagnetic Field (ELF) and Therapeutic Application of a Musically Modulated Electromagnetic Field (TAMMEF)

APOBEC3G exerts its antiviral activity by targeting to retroviral particles and inducing viral DNA hypermutations in the absence of Vif. However, the mechanism by which APOBEC3G is packaged into virions...Full Text Available

2004-11-01

474

ATP-gated P2X₃ receptors constitute a positive autocrine signal for insulin release in the human pancreatic ? cell

This study investigated the effects of electromagnetic fields on enzymes involved in purine metabolism in human peripheral blood mononuclear cells in vitro. Cells were obtained from 20 volunteers. We...Full Text Available

2009-01-01

475

A unified framework for capturing facial images in video surveillance systems using cooperative camera system

Extracellular ATP has been proposed as a paracrine signal in rodent islets, but it is unclear what role ATP plays in human islets. We now show the presence of an ATP signaling pathway that enhances...Full Text Available

2010-04-06

476

A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates

Low resolution and un-sharp facial images are always captured from surveillance videos because of long human-camera distance and human movements. Previous works addressed this problem by using an active camera to capture close-up facial images without considering human movements and mechanical delays of the active camera. In this paper, we proposed a unified framework to capture facial images in video surveillance systems by using one static and active camera in a cooperative manner. Human faces are first located by a skin-color based real-time face detection algorithm. A stereo camera model is also employed to approximate human face location and his/her velocity with respect to the active camera. Given the mechanical delays of the active camera, the position of a target face with a given delay can be estimated using a Human-Camera Synchronization Model. By ...

2008-04-01

477

Sequences homologous to the human x- and y-borne zinc finger protein genes (ZFX/Y) are autosomal in monotreme mannals

Utilizing the CEPH reference panel and genotypic data for 53 markers, we have constructed a 20-locus multipoint genetic map of human chromosome 4. New RFLPs are reported for four loci. The map integrates...Full Text Available

1991-05-01

478

Pharmacodynamics of a novel designer natriuretic peptide, CD-NP, in a first-in-human clinical trial in healthy subjects.

The human zinc finger protein genes (ZFX/Y) were identified as a result of a systematic search for the testis-determining factor gene on the human Y chromosome. Although they play no direct role in sex determination, they are of particular interest because they are highly conserved among mammals, birds, and amphibians and because, in eutherian mammals at least, they have active alleles on both the X and the Y chromosomes outside the pseudoautosomal region. We used in situ hybridization to localize the homologues of the zinc finger protein gene to chromosome 1 of the Australian echidna and to an equivalent position on chromosomes 1 and 2 of the playtpus. The localization to platypus chromosome 1 was confirmed by Southern analysis of a Chinese hamster [times] platypus cell hybrid retaining most of platypus chromosome 1. This localization is consistent with the cytological homology of chromosome 1 between the two species. The zinc finger protein ...

1993-02-01

479

Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene

CD-NP is a novel chimeric natriuretic peptide (NP) consisting of the 22-amino-acid (AA) human C-type natriuretic peptide (CNP), a venodilating peptide with limited renal actions and minimal effects on blood pressure, and the 15-AA C-terminus of Dendroaspis NP (DNP). The rationale for the design of CD-NP was to enhance the renal actions of CNP, the ligand for natriuretic peptide receptor-B, but without inducing excessive hypotension. Here we report the first-in-human studies for CD-NP, which represent the first successful clinical testing of a chimeric NP demonstrating in normal human volunteers that CD-NP possesses cyclic guanosine monophosphate-activating, natriuretic, and aldosterone-suppressing properties without inducing excessive hypotension, laying the foundation for additional studies on this first-in-class new cardiovascular therapeutic in human heart failure, which are now underway worldwide. ...

2009-04-24

480

Mapping of the gene encoding the melanocortin-1 ([alpha]-melanocyte stimulating hormone) receptor (MC1R) to human chromosome 16q24. 3 by fluorescence in situ hybridization

Pancreatitis-associated protein (PAP) is a secretory pancreatic protein present in small amounts in normal pancreas and overexpressed during the acute phase of pancreatitis. In this paper, the authors describe the cloning, characterization, and chromosomal mapping of the human PAP gene. The gene spans 2748 bp and contains six exons interrupted by five introns. The gene has a typical promoter containing the sequences TATAAA and CCAAT 28 and 52 bp upstream of the cap site, respectively. They found striking similarities in genomic organization as well as in the promoter sequences between the human and rat PAP genes. The human PAP gene was mapped to chromosome 2p12 using rodent-human hybrid cells and in situ chromosomal hybridization. This localization coincides with that of the reg/lithostathine gene, which encodes a pancreatic secretory protein structurally related to PAP, suggesting that both genes ...

1994-01-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

481

Mapping cis-Regulatory Domains in the Human Genome UsingMulti-Species Conservation of Synteny

[alpha]-Melanocyte stimulating hormone ([alpha]-MSH), a hormone originally named for its ability to regulate pigmentation of melanocytes, is a 13-amino-acid post-translational product of the pro-opiomelanocortin (POMC) gene. [alpha]-MSH and the other products of POMC processing, which share the core heptapeptide amino acid sequence Met-Glu (Gly)-His-Phe-Arg-Trp-Gly (Asp), the adrenocorticotropic hormone (ACTH), [beta]-MSH, and [gamma]-MSH, are collectively referred to as melanocortins. While best known for their effects on the melanocyte (pigmentation) and adrenal cortical cells (steroidogenesis), melanocortins have been postulated to function in diverse activities, including enhancement of learning and memory, control of the cardiovascular system, analgesia, thermoregulation, immunomodulation, parturition, and neurotrophism. To identify the chromosomal band encoding the human melanocortin-1 receptor gene, 1 [mu]g of an EMBL clone coding region of the ...

1994-01-15

482

Identification, characterization, and chromosomal localization of the human homolog (hES) of ES/130

Our inability to associate distant regulatory elements with the genes that they regulate has largely precluded their examination for sequence alterations contributing to human disease. One major obstacle is the large genomic space surrounding targeted genes in which such elements could potentially reside. In order to delineate gene regulatory boundaries we used whole-genome human-mouse-chicken (HMC) and human-mouse-frog (HMF) multiple alignments to compile conserved blocks of synteny (CBS), under the hypothesis that these blocks have been kept intact throughout evolution at least in part by the requirement of regulatory elements to stay linked to the genes that they regulate. A total of 2,116 and 1,942 CBS>200 kb were assembled for HMC and HMF respectively, encompassing 1.53 and 0.86 Gb of human sequence. To support the existence of complex long-range regulatory domains within these CBS we ...

2005-06-13

483

Characterization of an oligopeptide chemoattractant receptor on human blood monocytes using a new radioligand

The chicken extracellular matrix glycoprotein ES/130 is necessary for epithelial-mesenchymal transformation in the developing hear and is also expressed in noncardiac chicken tissues such as limb and notochord. We have identified hES, the human homology of chicken ES/130. Fluorescence in situ hybridization analysis (FISH) localizes hES to human chromosome 20p11.2-p12. FISH analyses of individuals with 20p12 deletions and affected by Alagille syndrome exclude hES as a candidate gene for this disorder. Reverse transcriptase-polymerase chain reaction studies reveal that hES is expressed in both fetal and adult human tissues and that hES expression in the left ventricle is increased in the failing adult heart. Further studies will evaluate how hES mutations may relate to congenital human cardiac and skeletal anomalies as well as cardiac remodeling in the adult. 16 refs., 2 figs.

1996-08-01

484

A Glance into the Future of Human Computer Interaction

The study of chemoattractant receptors on human monocytes had been limited by the lack of a radioligand suitable for use with the small numbers of cells routinely available from human donors. A new synthetic oligopeptide radioligand f(/sup 35/S)Met-leu-phe, with a higher specific radioactivity than was available with the tritiated compound, was used to characterize a chemoattractant receptor on freshly isolated human blood monocytes. These cells bind f(/sup 35/)met-leu-phe with a dissociation constant (KD) of 30.2 +/- 5.6 nM and contain 84,000 +/- 11,300 receptors per cell. f(/sup 35/)met-leu-phe does not bind specifically to blood lymphocytes. The specificity of the oligopeptide receptor on monocytes is indistinguishable from the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes. Using f(/sup 35/)met-leu-phe, it will now be feasible to study the chemotactic peptide receptor on ...

1984-03-01

485

CERN Document Server

Computers have a direct impact on our lives nowadays. Human's interaction with the computer has modified with the passage of time as improvement in technology occurred the better the human computer interaction became. Today we are facilitated by the operating system that has reduced all the complexity of hardware and we undergo our computation in a very convenient way irrespective of the process occurring at the hardware level. Though the human computer interaction has improved but it's not done yet. If we come to the future the computer's role in our lives would be a lot more rather our life would be of the artificial intelligence. In our future the biggest resource would be component of time and wasting time for a key board entry or a mouse input would be unbearable so the need would be of the computer interaction environment that along with the complexity reduction also minimizes the time wastage in the ...

2011-01-01

486

Molecular cloning, characterization, and expression of human ADP-ribosylation factors: Two guanine nucleotide-dependent activators of cholera toxin

Growth hormone-like factor produced by the tapeworm, Spirometra mansonoides, displaces human growth hormone (hGH) from its receptors on cultured human lymphocytes

ADP-ribosylation factors (ARFs) are small guanine nucleotide-binding proteins that enhance the enzymatic activities of cholera toxin. Two ARF cDNAs, ARF1 and ARF3, were cloned from a human cerebellum library. Based on deduced amino acid sequences and patterns of hybridization of cDNA and oligonucleotide probes with mammalian brain poly(A)"+ RNA, human ARF1 is the homologue of bovine ARF1. Human ARF3, which differs from bovine ARF1 and bovine ARF2, appears to represent a newly identified third type of ARF. Hybridization patterns of human ARF cDNA and clone-specific oligonucleotides with poly(A)"+ RNA are consistent with the presence of at least two, and perhaps four, separate ARF messages in human brain. In vitro translation of ARF1, ARF2, and ARF3 produced proteins that behaved, by SDS/PAGE, similar to a purified soluble brain ARF. Deduced amino acid sequences of ...

1989-01-01

487

The evolution of human culture during the later Pleistocene: Using fauna to test models on the emergence and nature of "modern" human behavior

An analogue of hGH isolated from plerocercoids of the tapeworm Spirometra mansonoides displaces ["1"2"5I]hGH from its receptors in rabbit, rat, and hamster liver membranes. Biologically, plerocercoid growth factor (PGF) is more similar to hGH than to other mammalian GH's but has not been shown to bond human cells. Receptors specific for hGH have been described on cultured human lymphocytes (IM-9). In this study, the authors compared the binding of PGF and hGH in IM-9 cells and in rabbit hepatic membranes. IM-9 lymphocytes (12 x 10"6 cells/tube) were incubated with ["1"2"5I]hGH and increasing concentrations of hGH (ng/ml) or PGF (serial dilutions) for 90 min at 30"0 C. Specific binding (B_0 - NSB) was determined for each dose of hGH or PGF and the binding curves were analyzed by logit-log regression. The results show that PGF displaced ["1"2"5I]hGH from human cells in a dose dependent manner (r = 0.98). Based on the IM-9 ...

1986-04-13

488

British Library Electronic Table of Contents (United Kingdom)

It has often been argued that the success and spread of modern humans 50,000years ago was due to a series of key behavioral shifts that conferred particular adaptive advantages. And yet, particularly during the African Middle Stone Age (MSA), some of these "modern" behaviors see only patchy expression across time and space. Recent models have proposed a link between the emergence of modern behaviors and environmental degradation and/or demographic stress. Under these models, modern behaviors represent a form of social/economic intensification in response to stress; if this were the case, signs of subsistence intensification should be more common during periods in which these behaviors are manifested than when they are not. In order to test these models, I analyzed faunal remains from Sibud...

2011-01-01

489

Physiologically Based Pharmacokinetic Modeling of Fetal and Neonatal Manganese Exposure in Humans: Describing Manganese Homeostasis during Development

British Library Electronic Table of Contents (United Kingdom)

Concerns for potential vulnerability to manganese (Mn) neurotoxicity during fetal and neonatal development have been raised due to increased needs for Mn for normal growth, different sources of exposure to Mn, and pharmacokinetic differences between the young and adults. A physiologically based pharmacokinetic (PBPK) model for Mn during human gestation and lactation was developed to predict Mn in fetal and neonatal brain using a parallelogram approach based upon extrapolation across life stages in rats and cross-species extrapolation to humans. Based on the rodent modeling, key physiological processes controlling Mn kinetics during gestation and lactation were incorporated, including alterations in Mn uptake, excretion, tissue-specific distributions, and placental and lactational transfer ...

2011-01-01

490

Long-Term Follow-Up of Patients with Breast Cancer Transplanted with Autologous Ex Vivo Expanded Peripheral Blood Progenitor Cells

British Library Electronic Table of Contents (United Kingdom)

Ex vivo expanded peripheral blood progenitor cells (PBPC) have been shown to provide rapid neutrophil engraftment, and in some patients, to eliminate neutropenia after transplantation to support high-dose chemotherapy. However, the effect of expansion culture on stem cell content and potential loss of stem cells caused by induction of differentiation remains a concern. We have transplanted 21 patients with breast cancer with expanded autologous PBPC, with 11 patients receiving expanded PBPC as their sole hematopoietic cell source. In these studies, the CD34+ cells were selected and cultured for 10 days in defined media containing 100 ng/mL each of recombinant human stem cell factor (rhSCF), recombinant human granulocyte colony stimulating factor (rhG-CSF), and recombinant human megakaryocy...

2006-01-01

491

Irradiation of human insulin in aqueous solution, first step towards radiosterilization

British Library Electronic Table of Contents (United Kingdom)

The degradation of irradiated human insulin in aqueous solutions was investigated in order to protect the protein against ionizing radiation. The influence of the drug concentration, excipients and irradiation temperature were studied.Aqueous solutions at pH 2 were irradiated by gamma rays or by accelerated electrons. Two different high-performance liquid chromatography (HPLC) methods were used: reverse-phase high-performance liquid chromatography (RP-HPLC)/UV and size exclusion liquid chromatography (SEC/UV) to investigate both the fragmentation and the formation of higher molecular weight proteins.In solution without excipients irradiated at ambient temperature at 10kGy, the loss of human insulin is almost complete. Addition of radio-protecting excipients (free radicals scavengers) and c...

2007-01-01

492

In vivo chicken model for peripheral intravascular human fibrin clot detection

Human climatic comfort within enclosing walls with varying strengths of infrared radiation reflection

A chicken model was prepared that provides a simple and economical method of evaluating the use of fibrin-specific monoclonal antibody 64C5 in the detection of peripheral vascular thrombi. Human fibrin was clotted in segments of a chicken's femoral artery and vein prior to intravenous injection of radioiodinated antibody 64C5. After a 3-hr perfusion time, the thrombosed and contralateral control segments of the vessels were excised and counted for radioactivity. The radiolabeled 64C5 uptake ratio of the thrombosed segment to the control segment was 5.4 +/- 1.2 (p less than 0.007) in the femoral artery, and 3.8 +/- 1.1 (p less than 0.02) in the femoral vein. This in vivo chicken model may also find application in studies of targeting agents for human fibrin.

1988-08-01

493

Crystal structure of the human centromeric nucleosome containing CENP-A

An experiment lasting a number of hours was carried out with 6 men under standardised climate chamber conditions to find out to what extent wallpaper that reflects about 65-75% in the infra-red range by comparison with normal wallpaper that reflect only 3-5% of heat, has measurable positive effects on the thermoregulation of the human body and the human sensation of temperature. The measurements of skin temperature and heat flow intensity in the deeper areas of the body and the periphery, and metabolic heat conversion measurements (indirect calorimetry) confirm that infra-red reflection of the heat irradiated from the body lead to a measurable heat recovery on the body surface with a reduction of metabolic conversion. It was proved that it is possible to reduce the average room temperature by up to 4 K whilst maintaining the same degree of thermal comfort, which corresponds to a 20% saving in heating energy. (orig./BWI).

1985-06-01

494

British Library Electronic Table of Contents (United Kingdom)

In eukaryotes, accurate chromosome segregation during mitosis and meiosis is coordinated by kinetochores, which are unique chromosomal sites for microtubule attachment. Centromeres specify the kinetochore formation sites on individual chromosomes, and are epigenetically marked by the assembly of nucleosomes containing the centromere-specific histone H3 variant, CENP-A. Although the underlying mechanism is unclear, centromere inheritance is probably dictated by the architecture of the centromeric nucleosome. Here we report the crystal structure of the human centromeric nucleosome containing CENP-A and its cognate ?-satellite DNA derivative (147 base pairs). In the human CENP-A nucleosome, the DNA is wrapped around the histone octamer, consisting of two each of histones H2A, H2B, H4 and CENP...

2011-01-01

495

Construction and Analytical Application of Internal Amplification Controls (IAC) for Detection of Food Supply Chain-Relevant Viruses by Real-Time PCR-Based Assays

British Library Electronic Table of Contents (United Kingdom)

Internal amplification controls (IACs) were constructed for incorporation into real-time nucleic acid amplification assays for bovine polyomavirus, hepatitis A virus, hepatitis E virus, human adenovirus, human norovirus genogroup I, human norovirus genogroup II, murine norovirus and porcine adenovirus. The addition of optimised amounts of IAC into the assays did not affect the limits of detection for each specific target virus. A poorly performed extraction of viral nucleic acids was simulated, and the effectiveness of IACs in identifying failed assays was demonstrated. The IACs constructed in this study can be reliably used in their specific assays to provide a robust control that can be routinely applied in the analysis of foods for viruses.

2011-01-01

496

An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes