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The dose-dependent transfer of [sup 203]Pb to milk and uptake in suckling rats and mice during a three-day nursing period was studied. On day 14 of lactation, the dams were administered a single intravenous dose of lead, labelled with [sup 203]Pb, in four or five doses from 0.0005 to 2.0 mg Pb/kg b.wt. There was a linear relationship between Pb levels in plasma and milk of both species. The Pb milk: plasma ratios at 24 hr after administration were 119 and 89 in mice and rats, respectively. At 72 hr the Pb milk: plasma ratio had decreased to 72 in mice and 35 in rats. The tissue levels of lead in the suckling rats and mice were also linearly correlated with lead concentration in milk at 72 hr, showing that milk could be used as an indicator of lead exposure to the suckling offspring. It is concluded that lead is transported into rat and mouse ...

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The distribution of lead in lactating mice and suckling offspring was studied with whole body autoradiography at 4 and 24 h after a single intravenous injection of {sup 203}Pb (50 mmol Pb/kg) to the dams. In the lactating mice on day 14 of lactation, the highest uptake of radioactivity at 4 h after administration was recorded in renal cortex, skeleton and liver. A high uptake was also evident in the mannary gland. At 24 h after administration, the radioactivity had decreased in most organs except in the skeleton. In the suckling pups, exposed to lead only via dams` milk for 24 h, the highest level of radioactivity was present in the intestinal mucosa and a much lower level of radioactivity was present in the skeleton. The mammary glands from mice given three daily intravenous injections of 240 {mu}mol Pb/kg were examined with X-ray microanalysis. At 4 h after the last injection, ...

International Nuclear Information System (INIS)

The gender-specific expression pattern of aromatase and 5alpha-reductases (5alpha-R) during brain development provides neurons the right amount of estradiol and DHT to induce a dimorphic organization of the structure. Polychlorinated biphenyls (PCBs) are endocrine disruptive pollutants; exposure to PCBs through placental transfer and breast-feeding may adversely affect the organizational action of sex steroid, resulting in long-term alteration of reproductive neuroendocrinology. The study was aimed at: a) evaluating the hypothalamic expression of aromatase, 5alpha-R1 and 5alpha-R2 in fetuses (GD20), infant (PN12), weaning (PN21) and young adult (PN60) male and female rats exposed to PCBs during development; b) correlating these parameters with the time of testicular descent, puberty onset, estrous cyclicity and copulatory behavior; c) evaluating possible alterations of some non reproductive behaviors (locomotion, learning and memory, depression/anxiety behavior). A ...

UK PubMed Central (United Kingdom)

1. One hundred and thirty-two antidromically identified paraventricular (PV) and supraoptic (SO) neurones were studied during milk ejection evoked by the suckling of the young, in thirty-four lactating...Full Text Available

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Concerns for potential vulnerability to manganese (Mn) neurotoxicity during fetal and neonatal development have been raised due to increased needs for Mn for normal growth, different sources of exposure to Mn, and pharmacokinetic differences between the young and adults. A physiologically based pharmacokinetic (PBPK) model for Mn during human gestation and lactation was developed to predict Mn in fetal and neonatal brain using a parallelogram approach based upon extrapolation across life stages in rats and cross-species extrapolation to humans. Based on the rodent modeling, key physiological processes controlling Mn kinetics during gestation and lactation were incorporated, including alterations in Mn uptake, excretion, tissue-specific distributions, and placental and lactational transfer ...

International Nuclear Information System (INIS)

Absorption of lead is known to be enhanced during infancy. In this study, the sites of intestinal accumulation of Pb by suckling rats have been determined under various conditions using "2"0"3Pb as a tracer. When "2"0"3Pb was administered intragastrically (IG) as a soluble salt, accumulation occurred primarily in the duodenum, regardless of dose and vehicle. In contrast, when rat pups suckled from a dam which had received "2"0"3Pb, the only region of the small intestine showing accumulation of radioactivity was the ileum. To confirm that these differences were not related to the route of administration, rat milk was labeled with "2"0"3Pb and was then used for IG administration. Once again, accumulation (4 hr post-administration) was confined to the ileum. When the dose was increased 10-fold, milk Pb displayed some accumulation in duodenal tissue, but very much less than that of soluble Pb at the same ...

British Library Electronic Table of Contents (United Kingdom)

Summary Background: Red blood cell (RBC) transfusion in hemorrhagic shock is life saving. However, several clinical trials have shown that blood transfusion in the critically ill patient might be associated with adverse outcomes. Furthermore, an association between prolonged blood storage and adverse effects of RBC transfusion has been postulated. The aim of this study is to examine the effect of blood storage time on resuscitation outcome, in an animal model of hemorrhagic shock. Methods: 20 Wistar rats were phlebotomized in order to induce reversible hemorrhagic shock. Half of them were resuscitated with blood stored for a short period of time (4 days), and the other ones were resuscitated with blood stored for a prolonged time (14 days). Blood samples for hemoglobin, pH, lactate, bicarb...

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The effect of prenatal cimetidine exposure (PreCM) on the duration of pentobarbital-induced narcosis (DPN) was assessed in immature (14- and 28-day old) and adult (50-60-day old) male and female rats. PreCM exposure was accomplished by treating mothers with cimetidine (CM) (20 mg/kg, ip) daily for the last two days of gestation and then (0.01% in drinking water) throughout lactation. Pregnant mothers of untreated offspring (Con) received saline. PreCM decreased DPN to 505 +/- 33 min (from 611 +/- 23 min in Con) and 393 +/- 190 min (from 686 +/- 44 min in Con) in 14-day old male and female rats, respectively. Similarly, PreCM decreased DPN to 88 +/- 15 min (from 134 +/- 3 min in Con) and 102 +/- 19 min (from 171 +/- 44 min in Con) in 28-day old male and female rats, respectively. At 21 days, PreCM did not alter DPN in either sex. At 50-60 days, however, it decreased DPN to 144 +/- 41 min (from 238 +/- 7 ...

Science.gov (United States)

Elution profiles of total lipoproteins, apolipoprotein B (apoB) concentrations in lipoproteins, and plasma triglyceride (TG) levels were examined in early-, late-, and non-lactating cows. Additionally, arteriovenous (A-V) differences were also measured to elucidate the uptake of TG and apoB-containing lipoproteins in mammary gland. Non-lactating cows showed three major peaks corresponding to triglyceride-rich lipoprotein (TRL), low density lipoprotein (LDL), and high density lipoprotein (HDL) fraction, whereas both early- and late-lactating cows revealed two peaks corresponding to TRL and HDL. The peak area of TRL in early- and late-lactating cows were significantly (p < 0.05) smaller than that in non-lactating cows. The plasma TG levels and apoB-48 concentrations of TRL in early- and late-lactating cows were also significantly (p < 0.01) lower. ...

UK PubMed Central (United Kingdom)

Peripartal serum alkaline phosphatase activity and lactate dehydrogenase activity were measured in 30 dairy cows in order to examine the association between retained fetal membranes and enzyme activity....Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVES. Worldwide declines in the duration of lactation are cause for public health concern. Higher levels of dichlorodiphenyl dichloroethene (DDE) have been associated with shorter durations of...Full Text Available

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The meeting featured seven sessions with 18 papers abstracted/indexed therein as follows: keynote address: tailings dams safety - implications for the dam safety community; 1 - design and performance: performance monitoring of dams: are we doing what we should be doing?; tailings dams from the perspective of conventional dam engineering; and design overview of Syncrude's Mildred Lake east toe berm; 2 - design and modelling: use of a 2D model for a dam break study on the ALCAN hydroelectric complex in Quebec; and spillway design implications resulting from changes in rainfall extremes; 3 - risk and dam safety I: closing the gaps in the dam safety guidelines; the reality of life safety consequence classification; and surveillance practices for the next millenium; 4 - risk and dam safety II: ...

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Reliability analysis is now being used to a large extent for several civil engineering structures. Such analysis has not been used for rockfill dams, the most common dams in Norway. Following work on reliability analysis for breakwaters, reliability analysis was then used to investigate the ability of the stone material on the upstream face of a rockfill dam to withstand wind generated waves. An attempt is made to follow up this work by including discharge overtopping on a rockfill dam in a reliability analysis. This report primarily goes through previous work on the required weight of protective stones on the downstream face of the dam for specified discharges over the dam and also deals with the probability formulation of extreme floods. A failure function with partial coefficients is formulated. But for reasons of economy the calibration of the partial ...

Energy Technology Data Exchange (ETDEWEB)

The French office for technical studies and control of big dams (BETCGB), has recently reedited the `guidebook for the control of dams in exploitation`. The aim of this document is to provide to the regional directions of industry, research and environment (DRIRE) a methodological help for their control actions of hydroelectric dams granted for exploitation. It comprises 6 chapters dealing with: the different type of dams, the inspection, the surveillance, the floods evacuation, the flood instructions, and the particular emergency plans. (J.S.)

Energy Technology Data Exchange (ETDEWEB)

In this handbook, technical reports on a number of hydro plants under construction are provided. In addition tables of compiled data are presented on a world-wide basis for the following: turbine and hydro generator contracts; hydropower resource potential and development; pumped storage plants; the major dams and hydro plants; roller compacted concrete dams and concrete faced rockfill dams; small hydropower. An address database of international organizations of relevance to hydropower development, national power authorities and nation committees of the International Commission an Large Dams is included. A final and major section of the handbook is a buyer's guide providing extensive company data and information on products and services. (UK)

International Nuclear Information System (INIS)

Some considerations regarding ice load in risk-based dam safety analysis are presented for small concrete dams. The most significant physical mechanisms leading to ice thrust on dams (such as thermal expansion and water level fluctuations) are outlined. Published literature on dam ice loads to examine ice load magnitude-return period relationships, sliding and overstressing failure mechanisms and structural performance criteria to resist ice loads, are also reviewed. Related loading combinations for structural safety evaluations were determined regarding the issue of simultaneity of ice loads with other events such as earthquakes. Parametric analyses were conducted on a small gravity dam section, 3m high, and a taller dam, 17.9 m high, to demonstrate the ultimate ice load carrying capability as a function of dam geometry and shear and ...

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Good performance in extended lactations of dairy cattle may have a beneficial effect on food costs, health, and fertility. Because data for extended lactation performance is scarce, lactation persistency has been suggested as a suitable selection criterion. Persistency phenotypes were calculated in several ways: P1 was yield relative to an approximate peak, P2 was the slope after peak production, and P3 was a measure derived to be phenotypically uncorrelated to yield and calculated as a function of linear regressions on test-day deviations of days in milk. Phenotypes P1, P2, and P3 were calculated for sires as solutions estimated from a random regression model fitted to milk yield. Because total milk yield, calculated as the sum of daily sire solutions, was correlated to P1 and P2 (r=0.30 ...

Science.gov (United States)

PMID:6621366

Science.gov (United States)

... similar to the S-wave tests except that exploding bridgewire detonators (EBW's) were used as the P-wave source. Crosshole ...

British Library Electronic Table of Contents (United Kingdom)

SummaryA meshless numerical model is proposed to investigate shallow-water dam break flows in 1D open channels. The numerical model is to solve the shallow water equations (SWE) based on smoothed particle hydrodynamics (SPH). The concept of slice water particles (SWP) is adopted in the SPH-SWE formulation. The numerical sensitivity analysis is first performed to study the appropriate SWP number and variable smoothing length through dam break flows in an idealized 1D channel with dry/wet beds. Extensive validation by comparison with laboratory and field data is next conducted for four benchmark problems, including dam break flows through a rough flat channel, a rough bumpy channel with various downstream boundary conditions, a nonprismatic channel, and a realistic scale model of the Toce ri...

British Library Electronic Table of Contents (United Kingdom)

Using a case-study, inductive, narrative approach, this article explores the history, drivers, benefits, and barriers to the Bakun Hydroelectric Project in East Malaysia. Situated on the island of Borneo, Bakun Dam is a 204m high concrete face, rock filled dam on the Balui River in the Upper Rajang Basin in the rainforests of Sarawak. Bakun Dam and its affiliated infrastructure could be the single largest and most expensive energy project ever undertaken in Southeast Asia. Based on data collected through site visits, original field research in Sarawak, and more than 80 research interviews, the article begins by teasing out the complex history and drivers behind the Bakun project before identifying a set of potential social, political, and economic benefits the project could deliver. It the...

UK PubMed Central (United Kingdom)

The mechanism of metabolic energy production by malolactic fermentation in Lactococcus lactis has been investigated. In the presence of L-malate, a proton motive force composed of a membrane potential...Full Text Available

UK PubMed Central (United Kingdom)

A clinical trial was conducted to determine whether prepartum intramammary pirlimycin reduces the proportion of nulliparous heifers with intramammary infection (IMI) during early lactation and improves...Full Text Available

UK PubMed Central (United Kingdom)

Background. It is currently recommended that diet of pregnant mothers contain 200–300 mg DHA/day. Aim. To determine whether DHA supplementation...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Stability concerns of the Par Pond Dam, an embankment structure in the Savannah River Site complex, resulted in a comprehensive evaluation of the state of its integrity. Specifically, excessive seepage through the embankment, slope failure due to an earthquake event as well as liquefaction potential of the embankment and the foundation are addressed and the potential of failure is evaluated. Lastly, remedial benefits of the addition of a berm structure are also assessed.

Science.gov (United States)

... F;qure Title phge 20 Rat B Spectral Density Measurements TNT Stimuli 70 21 Rat B Spectral Density Measurements Neutral Stimuli 71 ...

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This issue of Barrages newsletter comprises three articles. The first article treats of the quality approach relative to the organization of the inspections of big and medium size dams. It summarizes the improvements of this approach added in 2003 after analysis of the experience feedback. The second article presents the conclusions of the decennial and annual inspections of dams in exploitation. Only the observations requiring a special follow-up are reported. The last article summarizes the activities of the control services for the third quarter of 2003: decennial and annual visits, important facts, administrative instructions, studies, projects and works, organization of services, technical studies etc.. (J.S.)

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Udgivelsesdato: 1995-Nov

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Although it has been established that lead is transferred in milk from mother to suckling offspring, the physiological processes and parameters involved are not well understood. Single i.v. doses (0.2 mg/kg) or p.o. doses (2 mg/kg) of radiolabeled lead were administered to lactating and nonlactating female mice, and lead concentrations in blood, plasma, and milk were determined during a 21-day period. Large differences in lead elimination were observed between lactating and nonlactation mice. A significant fraction (25%) of the initial maternal dose (absorbed dose) was transferred to the suckling pups. The ratio of lead concentration in milk to lead concentration in plasma was found to be nearly constant over time. However, the milk-to-blood concentration ratios decreased during the same period. Furthermore, the concentration of lead in milk exceeded the plasma concentration by a factor of approximately 25, indicating that there is a ...

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This report examines the use of probabilistic methods in dealing with the problem of potential earthquake-induced liquefaction of foundation soils at an example dam site located in the central United States, near the New Madrid earthquake zone. The example dam is assumed to be a 1-mile long rolled-filled embankment founded on a 100-ft deep deposit of interbedded alluvial gravels, sands, silts, and clays. The study is seen as an opportunity to examine probabilistic concepts and procedures in the framework of an example engineering project. In this context, the main practical value of a probabilistic approach is that it permits more informed decision making about further data acquisition, additional engineering analysis, and if necessary, remedial action. The specific aim of the study is to show how probabilistic procedures complement and help to reinterpret the results of deterministic (earthquake-induced) liquefaction analysis. The procedures ...

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The guiding mechanism is attached by a hinge (swivel) to the supporting frame, and the frame is equipped by hinges (swivels) with hydraulic or pneumatic cylinders mounted on its ends and is attached by hinges (swivels) to the coke ejector and guide respectively. This increases the productivity and efficiency of operating the system.

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Pumped storage plants 20 are a relatively common type.They use a dam to create an upper reservoir ...Some pumped storage plants use the same water turbine and electric generator for both operating periods.That is,

UK PubMed Central (United Kingdom)

On the west flank of the Wind River Mountains, Wyoming, are several large lakes occupying glacially scoured depressions dammed by terminal moraines. Fremont, Willow, and New Fork Lakes, having maximal...Full Text Available

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Failure of a dam is something we hope never happens. But if a failure occurs, it`s important to study the circumstances in order to expand our knowledge base, and then apply what we learn to other structures.

British Library Electronic Table of Contents (United Kingdom)

Volatile fatty acids (VFA), produced in the rumen by microbial fermentation, are the main energy source for ruminants. The VFA profile, particularly the nonglucogenic (acetate, Ac; butyrate, Bu) to glucogenic (propionate, Pr) VFA ratio (NGR), is associated with effects on methane production, milk composition, and energy balance. The aim of this study was to evaluate extant rumen VFA stoichiometry models for their ability to predict in vivo VFA molar proportions. The models were evaluated using an independent data set consisting of 101 treatments from 24 peer-reviewed publications with lactating Holstein cows. All publications contained a full diet description, rumen pH, and rumen VFA molar proportions. Stoichiometric models were evaluated based on root mean squared prediction error (RMSPE)...

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Chemical admixtures are used in dam construction to improve plasticity of the dry materials mixture over time. Roller compacted concrete (RCC) has been used on many dam projects in China. However, the use of RCC has frequently resulted in water reduction problems. This paper provided details of an admixture based on polycarboxylate ether (PCE) which was developed to improve the quality of RCC constructions at the JinHong dam in China. Use of the polymer at the JinHong dam resulted in a vibration sensitive concrete that was sustained over time. Under identical mix-design and compaction conditions in the laboratory, specific gravity of the RCC was increased from 2417 kg/m{sup 3} to 2463 kg/m{sup 3}. The high specific gravity of the material resulted in satisfactory strength data from the dam project. The key-ratio of the splitting tensile strength versus compressive strength was ...

UK PubMed Central (United Kingdom)

1. In normal rats and rats with bladder hypertrophy secondary to outflow obstruction, undergoing continuous cytometry, we examined the responses to the selective alpha 1-adrenoceptor antagonist doxazosin...Full Text Available

UK PubMed Central (United Kingdom)

Alterations in basement membrane components, notably proteoglycans, in a rat model of polycystic kidney disease have been investigated. Rats were fed phenol II (2-amino-4-hydroxyphenyl-5-phenyl thiazole)...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundCompared to outbred Sprague Dawley (SD) rats, inbred Brown Norway (BN) rats exhibit less prepulse inhibition of startle (PPI) at long prepulse intervals,...Full Text Available

UK PubMed Central (United Kingdom)

An enterotoxin D (SED)-producing strain of Staphylococcus aureus was used to infect one mammary gland of each of 17 lactating dairy cows. All glands became infected and shed bacteria...Full Text Available

UK PubMed Central (United Kingdom)

Veterinarians and farmers employing multivalent killed vaccines in lactating dairy cows have reported transient losses in milk production. Few studies have quantified this loss. In this report, effects...Full Text Available

UK PubMed Central (United Kingdom)

Erythrocytes serve as reservoirs for cis- and trans-epoxyeicosatrienoic acids (EETs). Incubation of rat red blood cells (RBCs) with cis- and...Full Text Available

UK PubMed Central (United Kingdom)

The concentration of apolipoproteins was measured by quantitative immunoelectrophoresis in rat serum, in the lipoprotein-free ultracentrifugal fraction (density greater than 1.21) of serum, and in renal...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Twenty-four male weanling rats were fed either copper-adequate or -deficient diets until 9 or 11 weeks of age. Deficient rat hearts had increased mitochondria: myofibril compared to adequate rats. Eleven week old deficient rat hearts had decreased mitochondria: myofibril as the hearts increased in weight, but the larger hearts had greater myofibril volume densities. Cardiac mitochondria of deficient rats appeared vacuolated with fragmented cristae and translucent matrix. Valves from copper deficient rats appeared to have less connective tissue and were fragmented in areas. For deficient rats, heart:body weights of 9 wk old rats were negatively correlated with bicuspid valve pathology scores, whereas tricuspid valve scores from 11 wk old rats were negatively correlated with myofibril volume densities. ...

Science.gov (United States)

Populations of a common forage fish, red shiner Notropis lutrensis, were sampled from four localities on the Brazos River, Texas, affected by cold-water discharge from a hydroelectric dam and from unaltered sites in the same region. Polymorphism at the Mdh-B locus, encoding supernatant malate dehydrogenase, indicates that populations within 57 km of the dam are distinctive from other regional populations and possess a unique Mdh-B allele, have significantly higher levels of heterozygosity at the Mdh-B locus, represent a homogeneous set that have significantly different Mdh-B zygotic frequencies from other regional populations, and have significantly different Mdh-B zygotic proportions than would be expected under a Hardy-Weinberg equilibrium. Increased levels of heterozygosity in fish within 57 km of the dam were correlated with discharge-associated fluctuations in water temperature at sampling stations.

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PMID:19169052

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No abstract prepared.

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The purpose of this study was to evaluate the toxicological effects of feeding the oils of Calophyllum inophyllum, Pentaclethra macrophylla and Terminalia catappa to rats. The effects on physical appearance, feed intake, weight gain, plasma and tissue cholesterol and triacyglycerol levels in rats with 5% of the oils in normal rat feed were determined. Weekly monitoring of the rats showed good physical appearance and steady weight gain, with no mortality recorded for the period of the study. Haematological analysis of the rats indicated that they were not anaemic. Histopathotogical examination of the sections of the heart, liver, kidney and spleen revealed moderate (T. catappa oil) to severe fatty change and necrosis in the liver. Glomerulonephrotic changes in the kidneys of rats fed with T...

International Nuclear Information System (INIS)

To examine the hormonal regulation of the ATP-dependent Ca"2"+ pump in the kidneys, the ATP-dependent Ca"2"+ uptake by the basolateral membrane vesicles in the renal cortex was measured using radioactive calcium ("4"5Ca"2"+) in rats with vitamin D deficiency or rats undergoing thyroparathyroidectomy. The V_m_a_x of the Ca"2"+ pump activity was increased not only by administering calcitriol, but also by normalizing the serum calcium level in vitamin D-deficient rats. PTH suppressed the Ca"2"+ pump activity in normocalcemic vitamin D-deficient rats. Thyroparathyroidectomy did not affect the Ca"2"+ pump activity in the kidneys of normal rats. It was concluded that the ATP-dependent Ca"2"+ pump activity was depressed by secondary hyperparathyroidism in vitamin D-deficient rats. (author).

International Nuclear Information System (INIS)

Diurnal and seasonal thermal constancy, a greatly delayed seasonal temperature maximum, and summer cool and winter warm conditions characterize the stream environment below a deep-release dam in Colorado. Low diversity index and equitability values and changes in macroinvertebrate species composition may result from failure of the temperature regime to provide the thermal stimuli essential for various life-cycle phenomena. It is hypothesized that the following sublethal effects, directly or indirectly resulting from the modified temperature regime, may further alter macroinvertebrate community structure: reduction of niche overlap and a shift toward an equilibrium community as a consequence of reduced environmental fluctuation; more intense competition associated with greater productivity; elimination of major invertebrate predators; and failure of the limited temperature range to provide optimal temperatures for various physiological processes. Effects of the ...

Energy Technology Data Exchange (ETDEWEB)

When oxygen is limiting, animals can ferment glucose via several metabolic pathways varying in energetic efficiency and leading to various end products (such as lactate, succinate, or propionate). Because the pH dependence of H/sup +/ production by fermentation is opposite to that by hydrolysis of adenosine triphosphate formed in the fermentation, the total number of moles of protons generated is always two per mole of fermentable substrate. However, two and three times more adenosine triphosphate can be turned over per mole of protons produced in succinate and propionate fermentations, respectively, than in lactate fermentation. At its limit, this advantage would achieve the same balance between H/sup +/ production and H/sup +/ consumption during ATP cycling that is observed in aerobic metabolism, a situation observed in certain alcohol fermentations. Since proton balance during anaerobiosis is clearly adaptable, we consider possible impact ...

Science.gov (United States)

The viability of osteocytes can be demonstrated in sawn decalcified sections of bone by their lactate dehydrogenase activity. In the cancellous bone of the femoral head, the proportion of lacunae containing viable osteocytes decreased from 88 +/- 7% (mean +/- SD) at 10-29 years to 58 +/- 12% (P Ultimate compressive strength did not correlate with osteocyte viability. In the femoral head there is gradual, age-related reduction in osteocyte viability that can be more pronounced in hip fracture. Osteocyte death may affect bone quality by impairing repair of fatigue damage. PMID:8275364

International Nuclear Information System (INIS)

Ten Holstein steers (579 kg average body weight) were fed either alfalfa hay (12.2% crude protein) or a 90% concentrate diet to supply 14.2 or 25.2 Mcal ME respectively for a minimum of 28 days. Samples of rumen epithelial tissue were removed at slaughter from the anterior ventral sac, washed free of feed particles and transported to the laboratory in oxygenated Krebs-Ringer bicarbonate buffer (KRB; pH 7.4). Papillae were weighed (100-200 mg) in triplicate into flasks containing 3 ml KRB with 1 mM glutamine or 5 mM glucose and acetate (50 mM), propionate (25 mM), butyrate (15 mM), lactate (1 mM) and glucose (5 mM) or glutamine (1 mM) as competing substrates. A parallel set of flasks contained 1 or .5 #mu#Ci of [U-"1"4C]-glutamine or glucose respectively for "1"4CO_2 production. There were no interactions with dietary energy intake and substrate addition. Increasing the dietary energy intake increased (P < .01) rates of uptake, "1"4CO_2 production and net ...

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This article describes acoustic methods used in the in-service inspection of the dams and peripheral concrete structures of the Toktogul, Kurpsai, and Bratsk hydroelectric and pumped storage plants. The tests were conducted to assess the compression strength, elasticity, and tensile strength of the concretes. Comparative evaluations against drill core studies proved the acoustic methods to be sufficiently accurate in predicting aging behavior and loss of mechanical and physical integrity in the concretes.

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This Executive Summary, Volume I, of the lower Flathead System Fisheries Study Final Report, was prepared to provide a study overview for persons who are not fisheries scientists. The contents provide an introduction to the study and its objectives, a short description of the study area, a discussion of the major findings and conclusions of the study, and the description of fisheries management alternatives available to managers of the lower Flathead system. Technical reports were prepared for those portions of the study dealing with the lower Flathead River and its tributaries, Volume II, and the South Bay of Flathead Lake, Volume III. The annual hydrographic regime of the Flathead system, consisting of upper rivers, lake and lower river, has been modified by the construction and operation of two major hydroelectric facilities, Hungry Horse Dam on the south fork Flathead River and Kerr Dam at the outlet of Flathead Lake. The modified ...

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Design-for-reliability concepts can be applied to the products of the construction industry, which includes buildings, bridges, transportation systems, dams, and other structures. The application of a systems approach to designing in reliability emphasizes the importance of incorporating uncertainty in the analyses, the benefits of optimization analyses, and the importance of integrating reliability, safety, and security. 4 refs., 3 figs.

International Nuclear Information System (INIS)

To determine a rat strain appropriate for carcinogenicity testing of FYX-051, a xanthine oxidoreductase inhibitor, we performed a 4-week oral toxicity study by administering 0.3, 1 and 3 mg/kg, and 1, 3 and 10 mg/kg of FYX-051 to male Sprague-Dawley (SD) and Fischer (F344) rats, respectively. Histopathology revealed that the degree of FYX-051-induced nephropathy was 3-fold stronger in SD rats than in F344 rats. Our previous study demonstrated that the key factor of species differences in FYX-051-induced nephropathy is purine metabolism. This observation led us to examine the involvement of purine metabolism in differences among two strains of rats. However, purine metabolism was proven not to be implicated as an important factor. Subsequently, other factors responsible for the strain differences were examined. FYX-051-induced increases in plasma xanthine concentrations were higher ...

UK PubMed Central (United Kingdom)

Pituitary Fshb concentrations increase markedly and selectively beginning on Postnatal Day 20 in the male rat. To evaluate the factors potentially responsible for this rise...Full Text Available

UK PubMed Central (United Kingdom)

Cervical spinal cord hemisection rostral to the phrenic nucleus leads to paralysis of the ipsilateral hemidiaphragm in adult rats. Respiratory function can be restored to the paralyzed hemidiaphragm...Full Text Available

UK PubMed Central (United Kingdom)

The actions of nicotine, hexamethonium, and ethanol on the hypothalamo-hypophysial system have been investigated in the rat. The antidiuretic action of nicotine was not inhibited by ethanol, nor by...Full Text Available

UK PubMed Central (United Kingdom)

1. Sacs 20 cm long were obtained from the upper half of the small intestine of bile fistula rats (bile duct cannulated 48 hours previously). The sacs were everted, filled with oxygenated phosphate...Full Text Available

UK PubMed Central (United Kingdom)

Recent clinical trials demonstrate that combined oral dosing with estrogen and progestin increases the incidence of breast cancer in post-menopausal women. Similarly, in a rat model system of...Full Text Available

UK PubMed Central (United Kingdom)

Separate groups of rats received 500 trials of lever-press training under autoshaping (food delivery followed 10-second lever presentations, or occurred immediately following a response); operant conditioning...Full Text Available

UK PubMed Central (United Kingdom)

In all mammals, tissue inflammation leads to pain and behavioral sensitization to thermal and mechanical stimuli called hyperalgesia. We studied pain mechanisms in the African naked mole-rat, an unusual...Full Text Available

UK PubMed Central (United Kingdom)

A retrospective study of the relationship of season to the absorption of radiolead in laboratory rats was performed using data representing 305 animals from 36 experiments over 6 calendar years. Male...Full Text Available

UK PubMed Central (United Kingdom)

In anaesthetized rats, extracellular and intracellular recordings were taken from 106 respiratory neurones in the intermediate region of the nucleus ambiguus. We observed unprovoked shortening of expiratory...Full Text Available

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1. Rates and rate coefficients of glucose utilization and replacement were determined with [5-3H]- and [U-14C]-glucose in rats starved for 24h, either conscious or under halothane anaesthesia, in a...Full Text Available

UK PubMed Central (United Kingdom)

Thiobenzamide (TB) is a potent hepatotoxin in rats, causing dose-dependent hyperbilirubinemia, steatosis, and centrolobular necrosis. These effects arise subsequent to and appear to result from...Full Text Available

UK PubMed Central (United Kingdom)

Rat somatotropin (growth hormone) was labelled biosynthetically by incubating anterior pituitary lobes with radioactive amino acids for 24 h in a simple buffered salts medium containing glucose. The...Full Text Available

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Mice and rats are important mammalian models in biomedical research. In contrast to other biomedical fields, work on sexual differentiation of brain and behavior has traditionally utilized comparative...Full Text Available

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BackgroundIn rats, alcohol exposure during the period of rapid brain growth produces long-term changes in the free-running period, photoentrainment and phase-shifting...Full Text Available

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1. The LD₅₀ of iodomethane orally administered to rats is 76mg./kg. body wt. but repeated daily doses of 30–50mg./kg. body wt. are without effect. 2. Oral doses of iodomethane to...Full Text Available

UK PubMed Central (United Kingdom)

To determine the mechanism of the cardiac dilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed chemically and morphologically. TG was...Full Text Available

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Experiments were conducted to determine the dose response of rat bladder urothelium to a range of different single and fractionated intravesicular doses of the carcinogen, N-methyl-N-nitrosourea (MNU)....Full Text Available

UK PubMed Central (United Kingdom)

1. Rates and rate coefficients of glucose utilization and replacement in post-absorptive rats, either conscious or under halothane anaesthesia, were determined in a thermoneutral environment by using...Full Text Available

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1. The excretion of para-aminohippurate (PAH) in the isolated perfused rat kidney was examined over a wide range of perfusate PAH concentrations (15 microM to 6 mM). PAH excretion increased steadily...Full Text Available

UK PubMed Central (United Kingdom)

Using 31P-nuclear magnetic resonance, we studied the relationship between myocardial high-energy phosphate content and flux values for the creatine kinase reaction in the living rat under inotropic...Full Text Available

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Changes in RNA synthesis in liver nuclei were observed at different ages and after hypophysectomy and hormone replacement in female Sprague-Dawley rats. As determined by the incorporation of [3H]UMP...Full Text Available

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NG2 chondroitin sulfate proteoglycan is a surface marker of oligodendroglial progenitor cells (OPCs) in various species. In contrast to well-studied rat OPCs, however, we found that purified...Full Text Available

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The suprachiasmatic nucleus (SCN) of the hypothalamus is thought to play a critical role in circadian rhythm generation and entrainment to the light/dark cycle. In adult rats, the SCN shows a circadian...Full Text Available

UK PubMed Central (United Kingdom)

1. The effect on rat liver peroxisomal beta-oxidation of feeding diets containing various amounts of dietary oils was investigated. With increasing amounts (5-25%, w/w) of soya-bean oil an apparent,...Full Text Available

UK PubMed Central (United Kingdom)

To determine the relative importance of different metabolites of vitamin D in bone growth and development, weanling male rat pups suckled by vitamin D-deficient mothers were given either calcitriol...Full Text Available

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The Wistar Kyoto (WKY) rat strain is a putative genetic model of comorbid depression and anxiety. Previous research showing increased κ-opioid receptor (KOR)...Full Text Available

UK PubMed Central (United Kingdom)

We present the results of an automated analysis of the morphometry of the pulmonary airway trees of the Sprague Dawley rat. Our work is motivated by a need to inform lower-dimensional mathematical...Full Text Available

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International Nuclear Information System (INIS)

Pregnant females and newborn rats were exposed to a gamma irradiation of 150 rads. The stage of gestation at the time of irradiation varied from 14 to 21 days. The newborn rats were irradiated at 0, 1 and 2 days of age. The effect of irradiation of foetus and newborn rats depends on the age of the animal at the time of irradiation. This effect was specially important at the beginning of the foetal life. Neonatal mortality, growth of body weight and adult brain development were investigated. A modification of germ cell radiosensitivity during the period studied, was emphasized.

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Absorption of ''organically bound'' "2"3"3U and "2"4"1Am from gastrointestinal tracts of adult rats was twice that of the inorganic nitrate form. There was no difference between transport of "2"3"2U and "2"3"3U by adult rats, but "2"3"2U absorption by newborn rats was four times that of "2"3"3U. Absorption of "2"3"8Pu nitrate through the gut of the newborn is relatively insensitive to dose but incorporation in the gut mucosa saturates at high dose levels. Absorption of "2"3"8Pu is greater at 4 hr of age than at 24 hr.

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(1972). Denmark Ekelund, L. Goethlin, J. Henrikson, H. Letter-to-the-

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The experiment was designed to study the effects of sodium pentobarbital on behavioral thermoregulation in rats and mice. Male Sprague-Dawley rats were given intraperitoneal (i.p.) injections of sodium pentobarbital in doses of 0, 1, 5, 10 or 15 mg/kg and male CBA/J mice were giv...

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The distribution of Lipiodol in the liver and lungs following arterial or portal injection was studied in normal (n=55) and cirrhotic rats (n=20). Using magnified xeroradiography and radioisotope labeled tracers, it was found that Lipiodol was deposited mainly in the liver and lung after either arterial or portal administration. In control rats after arterial injection, deposits in the lung peaked after 2 hours and gradually declined over 48 hours; whereas after portal injection, the deposit steadily increased for 48 hours. Twenty-five percent of cirrhotic rats demonstrated a Lipiodol-induced miliary pattern in the lung. An increased number of portosystemic shunts in cirrhotic rats was also noted. These results suggest that cirrhosis of the liver may be a potential risk factor for developing pulmonary complications after Lipiodol administration. (orig.).

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The purpose of this study was to investigate whether the expression of specific genes in peripheral blood can be used as surrogate marker(s) to detect and distinguish target organ toxicity induced by chemicals in rats. Rats were intraperitoneally administered a single, acute dose of a well-established hepatotoxic (acetaminophen) or a neurotoxic (methyl parathion) chemical. Administration of acetaminophen (AP) in the rats resulted in hepatotoxicity as evidenced from elevated blood transaminase activities. Similarly, administration of methyl parathion (MP) resulted in neurotoxicity in the rats as evidenced from the inhibition of acetyl cholinesterase activity in their blood. Administration of either chemical also resulted in mild hematotoxicity in the rats. Microarray analysis of the global ...

International Nuclear Information System (INIS)

The radioprotective effects of Liv.52 on tissue-reduced glutathione (GSH) levels were studied in rats. Adult female Sprague Dawley rats were exposed to whole body gamma radiation of 4 Gy and 8 Gy. Prior to radiation exposure, Liv.52 was fed, one ml per rat, daily for 15 days. Three days after radiation exposure, reduced glutathione levels in the liver, spleen, kidney and blood were studied. Liv.52 was beneficial in restoring the spleen weight to body weigh t ratio in the animals of the 4 Gy group. In the spleen and liver, Liv.52 helped to restore reduced glutathione in sub-lethally exposed rats. Blood-reduced glutathione was found to be normal in both groups of experimental rats who received Liv.52. The above results exhibit the radioprotective effects of Liv.52 in relation to tissue-reduced glutathione in experimental rats exposed to sub-lethal doses of ...

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Systemic and splanchnic hemodynamics of the chronic bile duct-ligated rat were characterized by radioactive microspheres. Conscious and pentobarbital sodium-anesthetized, bile duct-ligated and sham-operated rats had cardiac output and regional organ blood flows determined. The conscious bile duct-ligated rat compared with the sham-operated showed a hyperdynamic circulation with an increased cardiac output and portal tributary blood flow. Pentobarbital sodium anesthesia induced marked hemodynamic changes in both sham-operated and bile duct-ligated rats. The latter group was especially sensitive to its effects; thus, comparison of cardiac output and portal tributary blood flow between anesthetized bile duct-ligated and sham-operated rats showed no significant differences. The authors conclude that the rat with cirrhosis due to chronic bile duct ligation is an ...

Science.gov (United States)

This peer-reviewed article from Bioscience journal is about restoring the Truckee river.Throughout the 20th century, the Truckee River that flows from Lake Tahoe into the Nevada desert was progressively dammed and dewatered, which led to the collapse of its aquatic and riparian ecosystems. The federal designation of the endemic cui-ui sucker (Chasmistes cujus) as endangered prompted a restoration program in the 1980s aimed at increasing spring flows to permit fish spawning. These flows did promote cui-ui reproduction, as well as an unanticipated benefit, the extensive seedling recruitment of Fremont cottonwood (Populus fremontii) and sandbar willow (Salix exigua). Recruitment was scattered in 1983 but extensive in 1987, when the hydrograph satisfied the riparian recruitment box model that had been developed for other rivers. That model was subsequently applied to develop flow prescriptions that were implemented from 1995 through 2000 and enabled further seedling ...

International Nuclear Information System (INIS)

The issue of global warming was discussed with particular reference to the changes that may occur in the hydrological regime within the coming decades in response to predicted changes in climate. Flood events for the 2050 time horizon were investigated along with the consequences on water management and dam safety. Dams operated by Hydro-Quebec are used for flood control, water supply, recreational activities and hydroelectricity. As such, the electric utility relies on methods to evaluate the adaptability of current management plans to climate change. This paper presented the results of a study conducted at the Moisie River watershed, located in northern Quebec. The HSAMI hydrologic model was used to evaluate and compare the occurrences where stream flows and water levels exceed critical values in order to assess the effectiveness of management plans in both current and climate change scenarios. The study considered two different approaches on ...

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This study was initiated to provide empirical data and analyses on the dam passage timing, travel rate, survival, and life history variation of fall Chinook salmon that are produced in the Clearwater River. The area of interest for this study focuses on the lower four miles of the Clearwater River and its confluence with the Snake River because this is an area where many fish delay their seaward migration. The goal of the project is to increase our understanding of the environmental and biological factors that affect juvenile life history of fall Chinook salmon in the Clearwater River. The following summaries are provided for each of the individual chapters in this report.

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Fisheries co-managers of U.S. v Oregon supported and directed the construction and operation of acclimation and release facilities for Snake River fall Chinook from Lyons Ferry Hatchery at three sites above Lower Granite Dam. In 1996, Congress instructed the U.S. Army Corps of Engineers (USCOE) to construct, under the Lower Snake River Compensation Plan (LSRCP), final rearing and acclimation facilities for fall Chinook in the Snake River basin to complement their activities and efforts in compensating for fish lost due to construction of the lower Snake River dams. The Nez Perce Tribe (NPT) played a key role in securing funding and selecting acclimation sites, then assumed responsibility for operation and maintenance of the facilities. In 1997, Bonneville Power Administrative (BPA) was directed to fund operations and maintenance (O&M) for the facilities. Two acclimation facilities, Captain John Rapids and Pittsburg Landing, are located ...

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The Washington Department of Fish and Wildlife (WDFW) has been contracted through the Bonneville Power Administration (BPA) and the Grant County Public Utility District (GCPUD) to perform an evaluation of juvenile fall chinook salmon (Oncorhynchus tshawytscha) stranding on the Hanford Reach of the Columbia River. The evaluation, in the fifth year of a multi-year study, has been developed to assess the impacts of water fluctuations from Priest Rapids Dam on rearing juvenile fall chinook salmon, other fishes, and benthic macroinvertebrates of the Hanford Reach. This document provides the results of the 2001 field season.

International Nuclear Information System (INIS)

The Washington Department of Fish and Wildlife (WDFW) has been contracted through the Bonneville Power Administration (BPA) and the Grant County Public Utility District (GCPUD) to perform an evaluation of juvenile fall chinook salmon (Oncorhynchus tshawytscha) stranding on the Hanford Reach. The evaluation, in the third year of a multi-year study, has been developed to assess the impacts of water fluctuations from Priest Rapids Dam on rearing juvenile fall chinook salmon, other fishes, and benthic macroinvertebrates of the Hanford Reach. This document provides the results of the 1999 field season.

International Nuclear Information System (INIS)

Radiosensitization by lactate, pyruvate, nalidixic acid and novobiocin was studied in exponentially growing SH-18L human lung fibroblasts. All the chemicals had a slight radiosensitizing effect at a low concentration and a definite effect at a higher one. Decreases in the D_0 and/or Dq values were present in each dose survival curve. Fibroblasts incubated with the low concentration of each chemical for 24 hrs after X irradiation showed no reduction in intracellular ATP content, whereas, the higher concentration produced a significant decrease. These observations suggest that the decrease in the ATP content may be involved in the radiosensitization of human fibroblasts at high concentrations of these chemicals. In contrast, radiosensitization at a low concentration is not explained by a relationship to ATP content. Different mechanisms may be involved in radiosensitization at low and high concentrations of these chemicals. (author).

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The winter syndrome in the gilthead sea bream Sparus aurata indicates that the species is exposed to critically low temperatures in Mediterranean aquaculture in winter. The present study of metabolic patterns and molecular stress responses during cold exposure was carried out to investigate this ?disease?, in light of the recent concept of oxygen and capacity limited thermal tolerance. The metabolic profile of fuel oxidation was examined by determining the activities of the enzymes hexokinase (HK), aldolase (Ald), pyruvate kinase (PK), l-lactate dehydrogenase (l-LDH), citrate synthase (CS), malate dehydrogenase (MDH) and 3-hydroxyacyl CoA dehydrogenase (HOAD) in heart, red and white muscle after exposure to temperatures of 10, 14 and 18?C. Especially, the increase in LDH activity combined ...

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Climate variability greatly affects animals through direct and indirect effects. Animals with slow reproductive adaptation to ecological changes such as large mammals are likely to have evolved mechanisms to anticipate early such impacts of climate variability on the environment. One of the adaptive mechanisms between reproductive costs and benefits in mammals affects parental investment through biases in sex ratio. Deer might be likely to show an early detection of climate variability because conception takes place in early autumn, but the main raising cost in deer concerns lactation, which takes place at the end of the following spring. The aim of this paper is to assess whether there is a relationship between global indices of climate variability such as El Ni?o-Southern Oscillation (EN...

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Abstract This study reports the effects of varying concentrations of copper sulfate on the metabolic and gene transcriptional profile of a recombinant Chinese hamster ovary (CHO) cell line producing an immunoglobulin G (IgG)-fusion protein (B0). Addition of 50 M copper sulfate significantly decreased lactate accumulation in the cultures while increasing viable cell density and protein titer. These changes could be seen from day 6 and became increasingly evident with culture duration. Reducing the copper sulfate concentration to 5 M retained all the above beneficial effects, but with the added benefit of reduced levels of the aggregated form of the B0 protein. To profile the cellular changes due to copper sulfate addition at the transcriptional level, Affymetrix CHO microarrays were used to...

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The objective of the present investigation was to develop a Bayesian framework for updating and integrating covariate information into key parameters of metabolizable energy (ME) systems for dairy cows. The study addressed specifically the effects of genetic improvements and feed quality on key parameters in current ME systems. These are net and metabolizable energy for maintenance (NEM and MEM, respectively), efficiency of utilization of ME for milk production (kL) and growth (kG), and efficiency of utilization of body stores for milk production (kT). Data were collated from 38 studies, yielding 701 individual cow observations on milk energy, ME intake, and tissue gain and loss. A function based on a linear relationship between milk energy and ME intake and correcting for tissue energy lo...

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Intercrosses of heterozygous pro-opiomelanocortin (POMC) mice result in homozygous null progeny at lower frequencies than expected. Genotyping offspring at pre-, peri-, and postnatal stages revealed that over half of homozygous null mutants die in the early postnatal stages. To investigate the reasons for this early postnatal lethality, we analyzed in detail different parameters in the initial hours after birth. POMC null mutants born to heterozygous dams presented at birth with corticosterone levels no different from wildtype littermates, were euglycemic, and had normal liver glycogen stores. However, already 30 min after birth corticosterone levels dropped by 80% and were undetectable thereafter, while corticosterone levels in wildtype animals increased during postnatal hours. Circulating adrenaline was almost below detection 1h after birth. Blood glucose levels fell sharply in all genotypes within 30 min after birth; however, wildtype and heterozygous pups ...

International Nuclear Information System (INIS)

The concentration of trace elements in brain sections was measured by synchrotron radiation X-ray fluorescence. The relative concentration was calculated by means of the normalization of Compton scattering intensity approximately 22 keV, after the normalization for collecting time of X-ray spectrum and the counting of the ion chamber, and subtracting the contribution of the polycarbonate film for supporting sample. Furthermore, the statistical evaluation of the element distribution in various regions of the brain sections of the 20-day-old rats was tested. For investigating the distribution of elements in the brain of iodine deficient rats, Wistar rats were fed with iodine deficient diet and deionized water (ID group). The rats were fed the same iodine deficient diet, but drank KIO_3 solution as control (CT group). The results showed that the contents of calcium (Ca) in thalamus (TH) and copper (Cu) and ...

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Previous research has shown that SAR hotspots are induced within the laboratory rat and that the resulting thermal hotspots are not entirely dissipated by bloodflow. Two experiments were conducted to determine if hotspot formation in the body and tail of the rat, which is radiation frequency specific, would have behavioral consequences. In the first experiment rats were placed in a plexiglas cage one side of which, when occupied by the rat, commenced microwave radiation exposure; occupancy of the other side terminated exposure. Groups of rats were tested during a baseline period to determine the naturally preferred side of the cage. Subsequent exposure to 360-MHz, 700-MHz or 2450-MHz microwave radiation was made contingent on preferred-side occupancy. A significant reduction in occupancy of the preferred side of the cage, and hence, microwaves subsequently occurred. Reduced exposure ...

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The effect of butylated hydroxytoluene (BHT) pretreatment (0.5% in the diet for 10 days) on the excretion, tissue distribution and DNA binding of orally administered (/sup 14/C)aflatoxin B1 (AFB1) was determined in male Fischer F344 rats. The amount of radioactivity excreted in the urine and feces by 24 hr was higher in BHT-treated rats than in controls. Treatment with BHT enhanced the excretion of water-soluble metabolites in the urine and in the large intestines plus feces at the earlier sampling times. The amount of radioactivity bound to hepatic nuclear DNA was six times less in the BHT-pretreated rats than in controls 6 hr after administration of the isotope. The half-lives of (/sup 14/C)DNA in the rat liver were 30 and 46 hr for control and BHT-pretreated rats, respectively. These results indicate that BHT pretreatment may protect the animal from the carcinogenic effects of ...

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Some non-human animals may possess the ability to recall the "what", "where", and "when" of a single past event. We tested the hypothesis that male meadow voles possess the capacity to recall the "what", "where", and "when" of a single past event associated with mate selection in two experiments. Briefly, male voles were allowed to explore an apparatus that contained two chambers. One chamber contained a day-20 pregnant female (24 h prepartum). The other chamber contained a sexually mature female that was neither pregnant nor lactating (REF female). Twenty-four hour after the exposure, the males were placed in the same apparatus, which was empty and clean. At this time, the pregnant female would have entered postpartum estrus (PPE), a period of heightened sexual receptivity. Males initially chose and spent significantly more time investigating the chamber that originally housed the pregnant female (now a PPE female) than the chamber that originally housed the REF ...

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The oral administration of 2,3-dihydroxybenzoic acid (DHB) to rats injected intravenously 1 hr previously with "2"3"9Pu citrate caused an increase in urinary excretion of Pu about 8 times that of animals treated with 0.9% NaCl (controls). Liver retention of Pu was decreased from 18% at 2 days in the control animals to 11% in DHB-treated rats. The skeletal retention was similarly reduced from 56% in the control group to 40% in the DHB-treated animals.

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Adult and newborn rats were exposed to "2"3"9PuO_2 aerosols of four different size distributions. Rats of both ages were killed at intervals between 1 hr and 60 days postexposure. There were marked age- and particle-related size differences in deposition, although retention was similar throughout. The differences in deposition are attributable to relatively greater deposition of larger particles in the upper respiratory tracts of newborns.

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These studies were undertaken to assess the effects of increased galactose (v increased glucose) metabolism via the polyol pathway on vascular filtration function in the kidneys, eyes, nerves, and aorta. Quantitative radiolabeled tracer techniques were used to assess glomerular filtration rate (GFR) and regional tissue vascular clearance of plasma 131I-bovine serum albumin (BSA) in five groups of male Sprague-Dawley rats: nondiabetic controls, streptozotocin-diabetic rats, nondiabetic rats fed a 50% galactose diet, diabetic rats treated with sorbinil (an aldose reductase inhibitor), and galactose-fed rats treated with sorbinil. Sorbinil was added to the diet to provide a daily dose of approximately .2 mmol/kg body weight. After 2 months of diabetes or galactose ingestion, albumin clearance was increased twofold to fourfold in the eye (anterior uvea, choroid, and retina), sciatic ...

UK PubMed Central (United Kingdom)

The muscarinic receptor binding of trazodone, a new nontricyclic antidepressant, was compared with established tricyclic antidepressants. The ability to inhibit the binding of [3H]-quinuclidinyl benzilate...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundTacrolimus (FK-506) is an immunosuppressant that binds to a specific immunophilin, resulting in the suppression of the cellular immune response during transplant rejection....Full Text Available

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Serum growth hormone (GH) was suppressed in female rats bearing mammary tumors induced by 7, 12, dimethylbenz(a)anthracene (DMBA) or N-nitrosomethylurea(NMU). Serum GH was suppressed due to treatment with a human GH analog produced by the plerocercoid stage of the tapeworm Spirometra mansonoides. Rats treated with plerocercoid growth factor (PGF) via plerocercoid infection had accelerated growth rates despite marked reductions in GH levels. Approximately two-thirds of the mammary tumors induced by either DMBA or NMU regressed during three weeks of exposure to PGF while most of the control tumors continued to grow. The data support an important regulatory role for GH in growth of mammary tumors in rats. PMID:3019224

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Hypertension is one of the most important modifiable risk factors for cardiovascular and cerebrovascular diseases. We investigated the potential antihypertensive effect of the purple passion fruit peel (PFP) extract, a mixture of bioflavonoids, phenolic acids, and anthocyanins, in spontaneously hypertensive rats and human. A high-performance liquid chromatography analysis was performed to identify the active ingredients of the PFP extract. In a rat liver toxicity assay, no hepatotoxicity was observed after 9 hours incubation in the presence of PFP extract (20 ?g/mL). The PFP extract also revealed hepatoprotection against chloroform (1 mmol/L)-induced liver injury. In the experimental model, 24 spontaneously hypertensive rats were divided into 3 treatment groups for a period of 8weeks: cont...

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The results of a histological study of normal osteoid tissue in man, the monkey, the dog, and the rat, using thin microtome sections of plastic-embedded undecalcified bone, are described. Osteoid tissue...Full Text Available

International Science & Technology Center (ISTC)

Morphological, Electrophysiological and Behavioral Investigations of the Nervous Tissue Developed from the Embryonic Matrix Zone Cells of the Dorsolateral Walls of Lateral Ventricles, Implanted into the Lesioned Regions of the Adult Rat's Brain

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In several vertebrate classes, the M?ller glia are capable of de-differentiating, proliferating, and acquiring a progenitor-like state in response to acute retinal injury or in response to exogenous growth factors. Our previous study has shown that M?ller cells can be activated and de-differentiated into retinal progenitors during Royal College of Surgeons (RCS) rats' degeneration, although the limited proliferation cannot maintain retinal function. We now report that rat retinal stem cells (rSCs) transplanted into RCS rats slowed the progression of retinal morphological degeneration and prevented the functional disruption. Further, we found that retinal progenitor cells labeled with Chx10 were increased significantly after rSCs transplantation, and most of them are mainly from activated M...

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(1974). Belgium Buttar, HS Coldwell, BB Thomas, BH Department of

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Russian 1997 p. 263-264 Russian Federation Tkach, VL Ushakova, GA

UK PubMed Central (United Kingdom)

In rats, drug-induced depression of the central nervous system has been shown generally to be associated with an elevation in level of total acetylcholine in the brain. This generalization held true...Full Text Available

International Nuclear Information System (INIS)

Simultaneous exposures of rats and hamsters to inhaled radon daughters, with and without uranium ore dust, were performed daily for five months. Pulmonary pathology developing in 6 to 13 mo after cessation of daily exposures included interstitial fibrosis, emphysema, epithelial hyperplasia, squamous metaplasia, and malignant neoplasia. Rats showed a greater variety and more severe response to these uranium mine inhalation exposures than did hamsters. Inhalation of radon daughters with uranium ore dust displayed the site of greatest damage, including squamous carcinoma, from the nasopharynx to the lungs. Sixty percent of the rats exposed to radon daughters with ore dust developed primary pulmonary carcinomas, providing an appropriate short-term experimental animal model for investigation of respiratory tract carcinogenesis in uranium miners.

UK PubMed Central (United Kingdom)

Astaxanthin (ATX) is a dietary carotenoid of crustaceans and fish that contributes to their coloration. Dietary ATX is important for development and survival of salmonids and crustaceans and has been...Full Text Available

UK PubMed Central (United Kingdom)

In the rat, some phthalates alter sexual differentiation at relatively low dosage levels by altering fetal Leydig cell development and hormone synthesis, thereby inducing abnormalities of the testis,...Full Text Available

UK PubMed Central (United Kingdom)

Metabotropic glutamate receptor 2/3 (mGluR2/3) agonists were shown previously to nonselectively decrease both cocaine- and food-maintained responding in rats. mGluR2 positive allosteric modulators (PAMs)...Full Text Available

International Nuclear Information System (INIS)

Comparison of the embryolethality of monomeric "2"3"9Pu injected at 9 days of gestation demonstrated that the sensitivity of Charles River CD strain was greater than that of Hilltop Wistar rats. Subsequent comparisons showed that rats derived from the Hilltop Fischer strain were more sensitive than the Wistar and, although not directly compared, more sensitive than the CD.

UK PubMed Central (United Kingdom)

1. The induction of long-term potentiation (LTP) was investigated in the rat dentate gyrus in the presence of ryanodine, an agent which is known to selectively bind to the ryanodine receptor (RyR) Ca2+...Full Text Available

UK PubMed Central (United Kingdom)

σ-Receptor (σR) antagonists have been reported to block certain effects of psychostimulant drugs. The present study examined the effects of σR ligands in rats trained to self-administer...Full Text Available

UK PubMed Central (United Kingdom)

In this study, bone mineral density (BMD) of normal (CON), ovariectomized (OVX) and partially nephrectomized (NFR) rats was measured by ³¹P NMR spectroscopy; bone matrix density was...Full Text Available

UK PubMed Central (United Kingdom)

We have shown that addition of exogenous delta-aminolaevulinic acid (ALA) to rat pancreatoma AR4-2J cells in culture leads to the increased production of porphobilinogen (PBG) and the accumulation of...Full Text Available

UK PubMed Central (United Kingdom)

The industrial solvent trichloroethylene (TCE) and its major metabolites have been shown to cause formic aciduria in male rats. We have examined whether chloral hydrate (CH) and trichloroacetic...Full Text Available

UK PubMed Central (United Kingdom)

Outbred Wistar rats were immunised with a single intraperitoneal injection of a mixture of 30 mg of A1(OH)3 and 100microng of gonococcal zeolite antigen (ZA). Ten days after immunisation, ZA prepared...Full Text Available

UK PubMed Central (United Kingdom)

Refeeding starved rats with an elemental diet resulted in a marked increase in crypt cell production rate (CCPR) in the proximal small intestine but not in the distal regions of the gut. Little effect...Full Text Available

UK PubMed Central (United Kingdom)

The occupational chemical 4-vinylcyclohexene diepoxide (VCD) selectively destroys ovarian small pre-antral follicles in rats and mice via apoptosis. Detoxification of VCD can occur through glutathione...Full Text Available

UK PubMed Central (United Kingdom)

1. Using a grease-gap recording technique we have investigated the effects of some antagonists of P2-purinoceptors on the depolarization of the rat isolated superior cervical ganglion evoked by 100...Full Text Available

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Seventy male Wistar rats were the recipients of labeled small lymphocytes (1.5 X 10(7) each) collected from the peripheral blood of syngeneic donors. The migrating labeled lymphocytes were traced in...Full Text Available

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The anesthetic agents methohexital (Brevital), Innovar, and ketamine (Ketaject) were examined for their effect on seizure duration following electroconvulsive stimulation in a rat model of electroconvulsive therapy (ECT). Compared to unanesthetized control animals, methohexital anesthesia shortened seizure duration by 42%, ketamine anesthesia tended to increase seizure duration, and Innovar anesthesia had no effect on duration of seizures. PMID:7349626

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The current investigation attempted to confirm the beneficial actions of a chemically characterized Radix Astragali decoction (AM-W) against type 2 diabetic (T2D) Sprague-Dawley (SD) rats. Using a case/control...Full Text Available

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Apoptosis and Proliferation During DicWoroacetic Acid (DCA) Induced Hepatocellular Carcinogenesis in the F344 Male Rat Chlorine, introduced into public drinking \\\\'ater supplies for disinfection, can react with organic compounds in surface waters to form toxic by-prod...

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Abstract SLC9A9 (solute carrier family 9, member 9, also known as Na+/H+ exchanger member (NHE9)) is a membrane protein that regulates the luminal pH of the recycling endosome, an essential organelle for synaptic transmission and plasticity. SLC9A9 has been implicated in human attention deficit hyperactivity disorder (ADHD) and in rat studies of hyperactivity. We examined the SLC9A9 gene sequence and expression profile in prefrontal cortex, dorsal striatum and hippocampus in two genetic rat models of ADHD. We report two mutations in a rat model of inattentive ADHD, the WKY/NCrl rat, which affect the interaction of SLC9A9 with calcineurin homologous protein (CHP). We observed an age-dependent abnormal expression of SLC9A9 in brains of this inattentive model and in the Spontaneous Hypertensi...

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Rats from an inbred Sprague-Dawley strain were fed semisynthetic diets with a low (0.3 energy percent (en %)), normal (3 en %) or high (10 en %) content of essential fatty acids (EFA) for at least three generations. Twenty-nine- to 33-day-old male rats were given a single intragastric dose of (1-14C)linoleic acid in olive oil, and the respiratory CO2, urine and feces were collected for 46 hours (expt 1) or 20 hours (expt 2). The 14C activity in respiratory CO2, feces, urine and the carcass was determined in both experiments. In experiment 2 it was also measured in samples of the brown fat, liver, adrenals, white fat, skeletal muscles and brain. In both experiments the rats fed the low EFA diet retained significantly more 14C activity than the rats fed the normal or high EFA diets. In all groups the concentration of label was highest in the brown fat and the adrenals, but the above differences among the ...

International Nuclear Information System (INIS)

Pregnant rats in 11d and 16d of their pregnancy were given one-off whole body exposure by "1"3"7Cs #gamma# rays to 0.2, 0.4, 0.9 and 2.0 Gy, respectively. Changes were observed in conditioned drinking response and cerebrum hippocampi cone cell number of the baby rats exposed to the #gamma# rays in different periods of their embryo development. As a result, that pregnant rats exposed to "1"3"7Cs #gamma# rays in different pregnant periods may induce significant decrease in cerebrum hippocampi cone cell number and achieving rate of conditioned drinking response of the babies. The dose-response relationship can be described by Y=a-b log_1_0D. The achieving rate of conditioned drinking response were significantly correlated to cerebrum hippocampi cone cell number in the babies, and the achieving rate of conditioned drinking response of the babies exposed at pregnant 11d was lower than others exposed at pregnant 16d

Energy Technology Data Exchange (ETDEWEB)

Municipal power systems developed early in the Pacific Northwest, but a new dimension was added in the 1930s when the public utility district (PUD) concept combining urban and rural areas encited vigorous debate and the public rejected private-utility candidates. A favorable national climate developed for consumer-owned systems during the 1920s and 30s encouraging the passage of the Federal Water Power Act, the creation of the Tennessee Valley Authority, the building of Hoover Dam, and the establishment of the Bonneville Power Administration. This article reviews developments following the Public Utility Act of 1935, which authorized the Federal Power Commission and the uniform system of accounts. After tracing the record of investigations and policy trends during the Roosevelt era, it concludes that utilities benefited from accounting regulations. (DCK)

Energy Technology Data Exchange (ETDEWEB)

In the flood surveys, it is fundamental to set up the relations of stage-damage. And this makes it possible to evaluate the flood regulation effects of the multipurpose dam and/or levee construction for optimum formulation. Unfortunately in the previous basin studies excluding the Han river basin survey, the conventional approaches on this matter have not been performed due to its time-consuming complexity. In this study we attempted a new method based on the disaster status, and constructed six stage-damage curves along the reaches of the Kum river basin, based upon the flood events records for recent 12 years (1981-92). (author). 12 refs., 3 tabs., 13 figs.

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This document represents the FY2002 BPA contract Statement of Work for the Yakama Nation (YN) portion of the project entitled 'Assessment of current and potential salmonid production in Rattlesnake Creek associated with restoration efforts'. The purpose of the project is to complete detailed surveys of water quality, fish populations, habitat conditions and riparian health in the Rattlesnake Creek sub-basin of the White Salmon River in south central Washington. Results of the surveys will be used to establish Rattlesnake Creek sub-basin baseline environmental factors prior to anticipated removal of Condit Dam in 2006 and enable cost-effective formulation of future watershed restoration strategies.

British Library Electronic Table of Contents (United Kingdom)

The objective of this study was to determine the effects of partially substituting cottonseed cake with graded levels of baobab (Adansonia digitata L.) seed cake (BSC) on milk yield and quality in Guernsey cows. Sixteen cows in mid-lactation and in their third parity were allocated to diets containing 0% (control), 5%, 10%, and 15% BSC in a completely randomized design. Each cow was given a daily feed ration of 6?kg and a basal diet of soya bean stover ad libitum. There were no differences in daily feed intake (P?>?0.05), but basal intake differed among all treatment groups with cows on the control diet having the highest intake (30???0.34?kg/day). Mean daily milk yield differed (P?P?P?P?P?>?0.05). These results indicate that BSC can substitute soya bean cake in dairy diets, but milk produ...

British Library Electronic Table of Contents (United Kingdom)

In order to achieve efficient d-lactic acid fermentation from a mixture of xylose and glucose, the xylose-assimilating xylAB operon from Lactobacillus pentosus (PXylAB) was introduced into an l-lactate dehydrogenase gene (ldhL1)-deficient Lactobacillus plantarum (?ldhL1-xpk1::tkt-?xpk2) strain in which the phosphoketolase 1 gene (xpk1) was replaced with the transketolase gene (tkt) from Lactococcus lactis, and the phosphoketolase 2 (xpk2) gene was deleted. Two copies of xylAB introduced into the genome significantly improved the xylose fermentation ability, raising it to the same level as that of ?ldhL1-xpk1::tkt-?xpk2 harboring a xylAB operon-expressing plasmid. Using the two-copy xylAB integrated strain, successful homo-d-lactic acid production was achieved from a mixture of 25?g/l xylos...

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Spot 14 (S14) is a protein that is abundantly expressed in lipogenic tissues and is regulated in a manner similar to other enzymes involved in fatty acid synthesis. Deletion of S14 in mice decreased lipid synthesis in lactating mammary tissue, but the mechanism of S14's action is unknown. Here we present the crystal structure of S14 to 2.65 {angstrom} and biochemical data showing that S14 can form heterodimers with MIG12. MIG12 modulates fatty acid synthesis by inducing the polymerization and activity of acetyl-CoA carboxylase, the first committed enzymatic reaction in the fatty acid synthesis pathway. Coexpression of S14 and MIG12 leads to heterodimers and reduced acetyl-CoA carboxylase polymerization and activity. The structure of S14 suggests a mechanism whereby heterodimer formation with MIG12 attenuates the ability of MIG12 to activate ACC.

International Nuclear Information System (INIS)

No-carrier-added astatine radionuclides produced in the "7Li-irradiated lead matrix were separated from bulk lead nitrate target by complexing At with insulin, followed by dialysis. The method offers simultaneous separation of At from lead as well as its complexation with insulin. The At-insulin complex might be a potential radiopharmaceutical in the treatment of hepatocellular carcinoma. The stability of At-insulin complex was checked by dialysis against deionized water and Ringer lactate (RL) solution. It has been found that the half-life of At-insulin complex is about #approx#12 h, when dialyzed against deionized water and is only 6 h, when dialyzed against RL solution having the same composition as blood serum. The 6 h half-life of this Insulin-At complex is perfect for killing cancer cells from external cell surfaces as the half-life of internalization of insulin molecule inside the cell is 7-12 h.

Science.gov (United States)

SUMMARY: Gastrointestinal helminths of Norway rat (Rattus norvegicus) from the Belgrade area were studied as a part of a wider ecological research of rats in Serbia (data on the distribution, population ecology, economic and epizoothiological-epidemiological importance, and density control). Rats were captured from May 2005 to July 2009 at both urban and suburban-rural sites. Of a total of 302 trapped rats 48% were males and 52% females, with 36.5% and 38.8% of juvenile-subadult individuals, per sex respectively. Intestinal helminth infection was noted in 68.5% of rats, with a higher prevalence in male hosts and in adult individuals. Higher numbers of infected juveniles-subadults were noted in suburban-rural habitats, while an opposite tendency was noted in adult rats. Seven helminth species were recovered, of which five were nematode (Heterakis spumosa, ...

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Milk can be a significant source of lead (Pb) for young mammals, including humans. Certain essential trace elements have previously been shown to be specifically associated with particular milk components and such associations often increase bioavailability. Thus, the first goal of this study was to determine the distribution of Pb in cream, casein, and whey fractions of various milks under various conditions using /sup 203/Pb as a tracer. In rat milk almost 90% of the Pb was found to be associated with the casein micelles, regardless of: 1) whether the milk was labeled in vivo or in vitro; b) whether the milk was fresh or frozen; and c) the added concentration of Pb. The remainder of the Pb was approximately equally distributed between cream and whey. A virtually identical pattern of Pb distribution was observed with bovine milk. Pb added to infant formula also associated predominantly with casein micelles, although the Pb content of this fraction was ...

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This study evaluated potential hydrogeologic mechanisms that may account for increasing moisture content conditions within the sediments of hydroelectric earth dams. Many such dams in Canada are reaching their life spans of approximately 40 years, therefore this study is considered to be an important and timely undertaking. The objective was to develop a method to numerically assess transient groundwater flow processes within old earth structures. The focus of this study was central Manitoba's Grand Rapids Generating Station where progressive movement within the till overburden has been observed since 1977. The possible source of water which is causing higher moisture content and weakness in the overburden material may be the slow wetting-up of the core and progressive increase in seepage to the downstream side. The evolution of flow through the core was evaluated with a modelling program called FRAC3D-VS which accounts for transient ...

British Library Electronic Table of Contents (United Kingdom)

The effects of oral administration of aqueous extract of Bulbine natalensis Baker stem at daily doses of 25, 50, and 100mg/kg body weight on the reproductive function of Wistar rats were evaluated. The indices of mating and fertility success as well as quantal frequency increased after 7 days of treatment in all the dose groups except the 100mg/kg body weight group. The number of litters was not statistically different (P>0.05) from the control. Whereas the absolute weights of the epididymis, seminal vesicle, and prostate were not affected, that of the testes was significantly increased. The epididymal sperm count, motility, morphology, and viscosity were not different from the control after 7 days of treatment. The male rat serum testosterone, progesterone, luteinizing hormone, and follic...