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RationalePrevious research has shown that rats exposed perinatally to phencyclidine (PCP) exhibited neuroanatomical abnormalities and altered cognition. In addition...Full Text Available

UK PubMed Central (United Kingdom)

A retrospective study of the relationship of season to the absorption of radiolead in laboratory rats was performed using data representing 305 animals from 36 experiments over 6 calendar years. Male...Full Text Available

International Nuclear Information System (INIS)

Pregnant rats in 11d and 16d of their pregnancy were given one-off whole body exposure by "1"3"7Cs #gamma# rays to 0.2, 0.4, 0.9 and 2.0 Gy, respectively. Changes were observed in conditioned drinking response and cerebrum hippocampi cone cell number of the baby rats exposed to the #gamma# rays in different periods of their embryo development. As a result, that pregnant rats exposed to "1"3"7Cs #gamma# rays in different pregnant periods may induce significant decrease in cerebrum hippocampi cone cell number and achieving rate of conditioned drinking response of the babies. The dose-response relationship can be described by Y=a-b log_1_0D. The achieving rate of conditioned drinking response were significantly correlated to cerebrum hippocampi cone cell number in the babies, and the achieving rate of conditioned drinking response of the babies exposed at pregnant ...

International Nuclear Information System (INIS)

Pregnant females and newborn rats were exposed to a gamma irradiation of 150 rads. The stage of gestation at the time of irradiation varied from 14 to 21 days. The newborn rats were irradiated at 0, 1 and 2 days of age. The effect of irradiation of foetus and newborn rats depends on the age of the animal at the time of irradiation. This effect was specially important at the beginning of the foetal life. Neonatal mortality, growth of body weight and adult brain development were investigated. A modification of germ cell radiosensitivity during the period studied, was emphasized.

UK PubMed Central (United Kingdom)

Previous studies have revealed marked differences in the incidence of leukemia between rats and mice exposed to 1,3-butadiene that do not appear to be readily explained on the basis of pharmacokinetics...Full Text Available

International Nuclear Information System (INIS)

Retention kinetics and tissue partition coefficients for "8"5Kr were determined in rats exposed to known concentrations of "8"5Kr gas. The tissue partition coefficients were used to calculate the relative tissue radiation dose, assuming exposure conditions equivalent to the maximum permissible concentration in air (MPC)a. The estimated radiation dose was highest in adrenals and body fat, about twice the dose estimated for the next highest tissue, ovaries. Saturation and desaturation curves show that the contents of the large intestines have a prolonged desaturation time compared to other samples analyzed.

International Nuclear Information System (INIS)

Pregnant rats were exposed to "8"5Kr for 4-6 hr and sacrificed immediately thereafter. The "8"5Kr concentration in the fetoplacental unit (FPU) was approximately the same at all gestation stages for intact FPU, isolated fetuses or fetal segments, as well as placentas and associated membranes. Maternal tissue concentrations varied over a wide range and only liver and intestine concentrations were relatively similar in both 20-day-gestation (dg) fetuses and adults.

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The effects of exposure to sublethal levels of microwaves were studied. Young albino rats of both sexes were exposed for 60 days to 7.5-GHz microwaves (1.0-KHz square wave modulation, average power 0.6 mW/cm2) for 3 h daily. During and after microwave exposure several physiological parameters were measured in both control and exposed animals. It was found that the animals exposed to microwaves tended to eat and drink less and thus showed a smaller gain in body weight. Some of the hematological parameters and organ weights were also significantly different. It is proposed that a nonspecific stress response due to microwave exposure and mediated through the central nervous system is responsible for the observed physiological changes.

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The proportion of energy absorbed by the tail of a rat carcass was determined. Male (288 g - 457 g) and female (195 g - 249 g) Sprague-Dawley rat carcasses were exposed to far-field, continuous-wave radiofrequency radiation (RFR). The carcasses were split into two mixed groups: one group was exposed to 700-MHz RFR; and the other, to 350-MHz RFR. Immediately after each exposure, the tail was severed, and the specific absorption rates (SAR) of the tail and body were determined by Dewar flask calorimetry. For example, a 195 g female exposed to 700 MHz yielded SARs of 1.26 and 3.64 mW/g (normalized to 1 nW/cm2 incident power density) for its body and tail, respectively; the tail contributed 6.7% to the total energy absorption. For a 205 g female exposed to 350 MHz, however, the tail contributed 19.0% to the whole-body absorption. Normalized SARs of 0.40 and 4.03 ...

International Nuclear Information System (INIS)

To determine a rat strain appropriate for carcinogenicity testing of FYX-051, a xanthine oxidoreductase inhibitor, we performed a 4-week oral toxicity study by administering 0.3, 1 and 3 mg/kg, and 1, 3 and 10 mg/kg of FYX-051 to male Sprague-Dawley (SD) and Fischer (F344) rats, respectively. Histopathology revealed that the degree of FYX-051-induced nephropathy was 3-fold stronger in SD rats than in F344 rats. Our previous study demonstrated that the key factor of species differences in FYX-051-induced nephropathy is purine metabolism. This observation led us to examine the involvement of purine metabolism in differences among two strains of rats. However, purine metabolism was proven not to be implicated as an important factor. Subsequently, other factors responsible for the strain differences were examined. FYX-051-induced increases in plasma xanthine concentrations were higher ...

Science.gov (United States)

... were erroneous. The oriental rat flea, Xenopsylla cheopis Rothschild, is considered to be the primary vector of ... laboratory and production of Weigl's exanthematous typhus vaccine. In Maintenance of hum...

British Library Electronic Table of Contents (United Kingdom)

Summary The effects of high-intensity pulsed electromagnetic stimulation (HIPEMS) on proliferation and differentiation of neonatal rat neural stem cells in vitro were investigated. Neural stem cells derived from neonatal rats were exposed to 0.1 Hz, 0.5-10 Tesla (T) [8 groups of B-I, respectively], 5 stimuli of HIPEMF. The sham exposure controls were correspondingly established. Inverted phase contrast microscope was used to observe the cultured cells, MTT assay to detect the viability of the cells as expressed by absorbance (A) value, and flow cytometry to measure differentiation of neural stem cells. The results showed that A values of neural stem cells in both 3.0 T and 4.0 T groups were significantly higher than the other groups 24 to 168 h post HPEMS, indicating a strong promotion of ...

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Previous research has shown that SAR hotspots are induced within the laboratory rat and that the resulting thermal hotspots are not entirely dissipated by bloodflow. Two experiments were conducted to determine if hotspot formation in the body and tail of the rat, which is radiation frequency specific, would have behavioral consequences. In the first experiment rats were placed in a plexiglas cage one side of which, when occupied by the rat, commenced microwave radiation exposure; occupancy of the other side terminated exposure. Groups of rats were tested during a baseline period to determine the naturally preferred side of the cage. Subsequent exposure to 360-MHz, 700-MHz or 2450-MHz microwave radiation was made contingent on preferred-side occupancy. A significant reduction in occupancy of the preferred side of the cage, and hence, microwaves subsequently ...

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Laboratory studies have been carried out to determine the toxicity of methiocarb pellets to wild trapped wood mice in order to provide some background data prior to any further evaluation of hazard in the field. In this study, wood mice were exposed to dry and to dampened methiocarb pellets in order to reproduce field trial application conditions. Field observations of methiocarb pellets indicate that the physical character changes under dry and wet weather conditions. This may affect their relative attractiveness and potential toxicity to wood mice. The laboratory assessment of exposed wood mice included measurement of brain esterase activities, methiocarb residues in selected mouse tissue, carcasses, and histological evaluation of kidney, liver and lungs.

British Library Electronic Table of Contents (United Kingdom)

Aim/hypothesis We examined whether the renin inhibitor, aliskiren, provides similar or greater protection than ACE inhibition from non-proliferative diabetic retinopathy and from the proliferative neoangiogenesis of oxygen-induced retinopathy. Methods Transgenic (mRen-2)27 rats, which overexpress mouse renin and angiotensin in extra-renal tissues, were studied. For diabetic studies, non-diabetic, diabetic (streptozotocin, 55?mg/kg), diabetic + aliskiren (10?mg?kg?1?day?1, pump), or diabetic + lisinopril (10?mg?kg?1?day?1, drinking water) rats were evaluated over 16?weeks. For oxygen-induced retinopathy studies, rats were exposed to 80% oxygen (22?h/day) from postnatal days?0 to 11, and then room air from postnatal days?12 to 18. Aliskiren (10 or 30?mg?kg?1?day?1, pump) or lisinopril (10?mg...

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The existence of stem cells committed to the T lymphoid lineage was deduced from studying how rat T and B stem cells differ in their expression of membrane W3/13 antigen and in their susceptibility in vivo to gamma irradiation. Stem cell activity of rat bone marrow and fetal liver was measured in long-term radiation chimeras using B and T cell alloantigenic surface markers to identify the progeny of donor cells. Monoclonal mouse anti-rat thymocyte antibody W3/13 labeled approximately 40% of fetal liver cells and 60-70% of young rat bone marrow cells (40% brightly, 25% dimly). Bright, dim, and negative cells were separated on a fluorescence-activated cell sorter. All B and T lymphoid stem cells in fetal liver were W3/13 bright, as were B lymphoid stem cells in bone marrow. W3/13 dim bone marrow had over half the T cell repopulating activity of unseparated marrow but gave virtually no B cell repopulation. ...

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The effects of repeated low-level nerve agent exposure on animal performance and lethality are a major concern of USAF Medical Research. This concern has generated interest in the role that pretreatment drugs such as pyridostigmine may play during simultaneous exposure to soman. This role was investigated by recording lethality, weights, symptoms, and cholinesterase (ChE) inhibition in rats chronically exposed to 4 levels of soman (32, 39, 48 or 59 micrograms/kg/day) while simultaneously receiving 10.0 milligrams/kg/day pyridostigmine, 1.0 milligrams/kg/day pyridostigmine, or vehicle via an osmotic pump. No effect (either protective or detractive) was found in the soman-poisoned animals due to the presence or absence of pyridostigmine. However, rat blood biochemistry is different from that of the primate, warranting further study in the primate before extrapolation to man.

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Some of the known toxic effects of lead in mammals including man are, impaired heme synthesis, anemia, nepatopathy, nephropathy, behavioral disorders and neuropathy. However, very little is known about the effect of lead on endocrine physiology. Some data are available on lead induced impairment of thyroid function in occupationally exposed men and experimental rats. As lead nitrate is largely consumed through water and food, in this study the wild rodents Funambulus pennanti were administered lead through their drinking water and their thyroid structure, radioiodine 131-I percentage uptake and protein bound iodine (PBI) level were assessed.

International Nuclear Information System (INIS)

The late effects of "2"3"9Pu have been studied after its administration to perinatal, juvenile and adult rats. Adults and weanlings were injected intravenously, newborns intracardially and 19-day foetuses by intravenous injection of the dam. Dose levels were selected to deliver radiation doses of approximately 7, 23, or 70 rads to the femur of all ages during the first 10 days post injection; in general these values were achieved as shown by tissue analysis. Dose rates subsequently diverged, resulting in widely varying cumulative radiation doses for the four age groups. Survival times of rats exposed post-natally were progressively decreased by increasing dose. No decrement in survival was found for those exposed prenatally. Bone tumour incidence was increased by exposure to Pu in all age groups. The younger rats were less sensitive on an administered dose basis, but perhaps more ...

International Nuclear Information System (INIS)

The influence of carbon monoxide (CO) exposure on regional cerebral blood flow (r-CBF) in rat brain was studied using autoradiography and "1"2"5I-IMP. Fuji computed radiography (FCR) was used to obtain improved autoradiograms in this study. R-CBF was determined in a relative measure by calculating hippocampus/cortex and putamen/cortex ratios of RI accumulation from the autoradiogram using a densitometer. Comparison of autoradiograms with pathological findings in the area of the hippocampus and putamen yield the following results. In the animals that were exposed to 6400 ppm or 10000 ppm of CO for 30 minutes, and then were followed up for 2 weeks without further exposure, r-CBF was decreased but no pathological changes occurred. In the animals that were exposed to 6400 ppm or 10000 ppm of CO, and then were followed up for 4 weeks without further exposure, pathological changes appeared. In animals exposed ...

Science.gov (United States)

The effects of high-intensity pulsed electromagnetic stimulation (HIPEMS) on proliferation and differentiation of neonatal rat neural stem cells in vitro were investigated. Neural stem cells derived from neonatal rats were exposed to 0.1 Hz, 0.5-10 Tesla (T) [8 groups of B-I, respectively], 5 stimuli of HIPEMF. The sham exposure controls were correspondingly established. Inverted phase contrast microscope was used to observe the cultured cells, MTT assay to detect the viability of the cells as expressed by absorbance (A) value, and flow cytometry to measure differentiation of neural stem cells. The results showed that A values of neural stem cells in both 3.0 T and 4.0 T groups were significantly higher than the other groups 24 to 168 h post HPEMS, indicating a strong promotion of the growth of neural stem cells (PHPEMS groups was the same as that in control group (P>0.05). It was suggested that 0.1 Hz, 5 pulses ...

Science.gov (United States)

Samples of geothermal scale formed from Magmamax No. 1 and Woolsey No. 1 wells in the Imperial Valley, Calif., were exposed to concentrated and dilute solutions of common laboratory reagents. The time of exposure and temperature of the reagent were also varied. Several reagents easily dissolved significant amounts of the scale. An in situ test was performed with marginal success.

International Nuclear Information System (INIS)

In 1998, research began at Idaho National Engineering and Environmental Laboratory to investigate the application of "6Li and "7Li isotopes to the measurement of neutron and gamma radiation. Various size pairs of "6Li and "7Li based detectors were exposed to mixed neutron and gamma radiation. Experiments demonstrated that these detectors could be used to measure low level neutron radiation in the presence of high level gamma radiation. (author)

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It has recently been found that many buildings in Taiwan were constructed with radioactively contaminated rebar, which raised great concern among the residents as well as governmental officials. In order to investigate the possible cytogenetic damage to the residents of contaminated buildings, a G-banding method was carried out on the lymphocytes of 30 radiation-exposed individuals from four families and one office building, as well as 15 control individuals from laboratory personnel. The estimated cumulative radiation doses for the exposed people range from 19.63 to 280.50 mSv. Altogether, 13 females and 17 males belonging to the radiation-exposed group, and 7 females and 8 males in the control group, were included in this study. With the exception of one sample, at least 500 metaphase spreads were scored and analyzed for each individual. All the recognizable structural aberrations of chromosomes or ...

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The effect of prenatal cimetidine exposure (PreCM) on the duration of pentobarbital-induced narcosis (DPN) was assessed in immature (14- and 28-day old) and adult (50-60-day old) male and female rats. PreCM exposure was accomplished by treating mothers with cimetidine (CM) (20 mg/kg, ip) daily for the last two days of gestation and then (0.01% in drinking water) throughout lactation. Pregnant mothers of untreated offspring (Con) received saline. PreCM decreased DPN to 505 +/- 33 min (from 611 +/- 23 min in Con) and 393 +/- 190 min (from 686 +/- 44 min in Con) in 14-day old male and female rats, respectively. Similarly, PreCM decreased DPN to 88 +/- 15 min (from 134 +/- 3 min in Con) and 102 +/- 19 min (from 171 +/- 44 min in Con) in 28-day old male and female rats, respectively. At 21 days, PreCM did not alter DPN in either sex. At 50-60 days, however, it decreased DPN to 144 +/- 41 min (from 238 +/- 7 min in Con) in ...

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The mechanisms of brown adipocyte proliferation and differentiation during cold acclimation (and/or adaptation to hyperphagia) have been studied by quantitative photonic radioautography. (/sup 3/H)thymidine was injected to warm-acclimated (25/sup 0/C) rats and to animals exposed to 5/sup 0/C for 2 days. Samples of interscapular brown adipose tissue were collected for quantitative analysis of mitotic frequencies at various periods of time (4 h-15 days) after the injection of (/sup 3/H)thymidine, the rats being maintained at the temperatures to which they were initially exposed. It was found that cold exposure for 2 days markedly enhanced mitotic activity in endothelial cells, interstitial cells, and brown preadipocytes rather than in fully differentiated brown adipocytes. The total tissue labeling index (percent of labeled nuclei) increased approx.70 times over control values. The authors now report that ...

Energy Technology Data Exchange (ETDEWEB)

A large variety of microwave producing devices are used in contemporary naval communications and weapons systems. Public and scientific concern about potential biological effects of microwave irradiation such as produced by these various devices requires documentations of such effects. Currently, the only well documented direct effect of microwaves is heating of the exposed organism. The present report is of a series of studies whose aim was to explore several microwave frequencies and their effect on performance and simultaneously to investigate the relationship to core heating in the exposed animals. Three difficult sized species of animals were used so that generalization to larger animals could be made. Rats, squirrel monkeys, and rhesus monkeys showed consistent effects of 60-minute exposures to microwaves when their body temperatures were increased at least 1 C above baseline temperatures. Performance was not reliably ...

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Anesthetized rats were exposed to 5.6-GHz continuous-wave radiofrequency radiation (RFR) at an average power density of 60 mW/Sq. cm (average specific absorption rate 12 W/kg). Exposure was performed to raise colonic temperature from 38.5 to 39.5C. Following acute administration of chlorpromazine, body temperature exhibited a faster return to baseline temperature when exposure was discontinued. When exposure was initiated at 38.5C and continued until lethal temperature resulted, chlorpromazine-treated animals exhibited significantly shorter survival times than saline-treated animals. Thus, although chlorpromazine enhanced thermoregulatory efficiency at colonic temperature below 39.5 deg C, the drug caused increased susceptibility to terminal RFR. The present results, when compared with previous studies of irradiation at 2.8 GHz, indicate that the effects of chlorpromazine on thermal response to RFR during intermittent and terminal exposure are ...

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(3H)Quinuclidinyl benzilate binding to rat brain muscarinic receptors decreased after repeated exposure to soman, a potent organophosphorus cholinesterase inhibitor. The topographical distribution of this decrement was analyzed by quantitative receptor autoradiography. After 4 weeks of soman, three times a week, quinuclidinyl benzilate binding decreased to 67 to 80% of control in frontal and parietal cortex, caudate-putamen, lateral septum, hippocampal body, dentate gyrus, superior colliculus, nucleus of the fifth nerve, and central grey. Minor or no decreases were observed in thalamic or hypothalamic nuclei, reticular formation, pontine nuclei, inferior colliculus, nucleus of the seventh nerve, and cerebellum. Scatchard analyses of saturation curves using frontal cortex sections from soman-treated rats revealed a decrease in maximal quinuclidinyl benzilate binding from that in control rats and a return toward control ...

International Nuclear Information System (INIS)

Radiation-induced enteritis is a well-recognized sequel of therapeutic irradiation. Therefore we examined the radioprotective properties of Punica granatum peel extract (PPE) on the oxidative damage in the ileum. Rats were exposed to a single whole-body X-ray irradiation of 800 cGy. Irradiated rats were pretreated orally with saline or PPE (50 mg/kg/day) for 10 days before irradiation and the following 10 days, while control rats received saline or PPE but no irradiation. Then plasma and ileum samples were obtained. Irradiation caused a decrease in glutathione and total antioxidant capacity, which was accompanied by increases in malondialdehyde levels, myeloperoxidase activity, collagen content of the tissue with a concomitant increase 8-hydroxy-2'-deoxyguanosine (an index of oxidative DNA damage). Similarly, pro-inflammatory cytokines (TNF-?, IL-1? and IL-6) and lactate dehydrogenase were elevated in ...

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Intact rat fat cell exposed to 12.5 ..mu..M (..gamma..-32P)ATP incorporate label into specific proteins within minutes. By solubilizing the reaction mixture with SDS which bypasses the subcellular fractionation steps, the labeled proteins can be identified in autoradiographs of SDS-PAGE gels. The most prominently labeled protein has an M/sub r/ of 42,000. Localization of this component to the cell surface can be made on the basis of inhibition of phosphorylation by addition of a protein derived from the rat brain with protein kinase inhibitory property, susceptibility of the phosphorylated protein to the tryptic digestion, inhibition of phosphorylation of this protein after brief exposure to melittin. To rule out the possibility that the cell surface protein might be a mitochondrial contaminant from broken cells, /sup 32/Pi-labeled and (..gamma..-/sup 32/P)ATP-labeled cells were chromatographed on a rabbit anti-pyruvate ...

International Nuclear Information System (INIS)

Cadmium is an environmental toxic metal implicated in human diseases. The mechanism of its toxicity is not fully understood. Therefore, the role of cadmium in renal toxicity, and the protective role of selenium against this toxicity were investigated. Forty-five male rats were used through out the study and divided into three groups of 15. The first group received saline solution daily for 10 days. The second group, received cadmium chloride (CdCl_2) (2 mg/kg body weight) intraperitoneally daily for a period of 10 days. The third group, received sodium selenite (1 mg/kg body weight, twice a day) and CdCl_2 (once a day) for a period of 10 days. The results showed that cadmium treatment increased renal lipid peroxidation (measured as malondialdehyde, MDA) which was associated with a significant decrease in the antioxidant systems such as reduced glutathione levels and the activities of glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). On the other hand, ...

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A hypothesis of microwave-induced circulatory under perfusion was tested in ketamine anesthetized rats whose heart rate, mean arterial pressure, pulse pressure, respiration rate, and body temperatures were monitored continuously. Fifty-eight ventral head and neck exposures in a waveguide consisted of sham-exposure and exposure to continuous wave (CW) and pulsed 1.25 GHz microwaves for 5 min. The 0.5 Hz and 16 Hz pulsemodulated microwaves were delivered at 400 kW peak power. The CW microwaves were 2 and 6.4 W. The average specific absorption rate was 4.75 W/kg per watt transmitted in the brain and 17.15 W/kg per watt transmitted in the neck. Respiration rate and mean arterial pressure were not altered. Changes in heart rate and pulse pressure were observed in rats exposed to higher power but not to the lower average power microwaves. Depression of pulse pressure, an indication of a decrease in stroke volume, and increased or ...

International Nuclear Information System (INIS)

Studies have linked cell phone radiation to health problems such as headaches, high blood pressure, cancer and more. There is a latency period for most diseases and it may take years and more studies before the required weight of evidence is established. But the effects are cumulative and precautions should be taken now before it is too late. The aim of the present study was to investigate if supplementation with antioxidants would protect heart and liver tissues from harmful radiation emitted by cell phone. Thirty two male albino rats were randomly divided into four equal groups: I- Control, II- Antioxidants treated group, III- 950 MHz EMR, IV- 950 MHz EMR + antioxidants. A 950 MHz EMR radiation (217-Hz pulse rate, 2-W maximum peak power, SAR Specific Absorption Rate"1.6 W/Kg) was applied to groups III and IV 60 min/day, for 30 days using an experimental exposure device. Antioxidants supplement (Vitamins A, E and C + Se) was administered to ...

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The proper selection of materials of construction is necessary to provide process equipment with optimum performance and corrosion resistance. If properly chosen, the selected material should deteriorate at a uniform, predictable rate, which will allow for maintenance or replacement at scheduled intervals. This concept of risk assessment for predictive maintenance is a minimum requirement for proper materials selection. Materials selection is based on prior service history, field corrosion tests, pilot-plant tests, and laboratory bench-top tests--in that relative order of usefulness. Corrosion test methods are usually divided into two groups: laboratory and field (plant-site) tests. The main difference between the two is that field test specimens are exposed to actual process conditions will all of the variables involved, while laboratory tests are a simulation of field conditions, even if actual ...

Science.gov (United States)

... F;qure Title phge 20 Rat B Spectral Density Measurements TNT Stimuli 70 21 Rat B Spectral Density Measurements Neutral Stimuli 71 ...

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The eastern oyster (Crassostrea virginica) developed neoplastic disorders when experimentally exposed both in the laboratory and field to chemically contaminated sediment from Black Rock Harbor (BRH), Bridgeport, Connecticut. Neoplasia was observed in oysters after 30 or 60 days of continuous exposure in a laboratory flow-through system to a 20 mg/L suspension of BRH sediment plus postexposure periods of 3, 30, or 60 days. Composite tumor incidence was 13.6% for both exposures. Tumor occurrence was highest in the renal excretory epithelium, followed in order by gill, gonad, gastrointestinal, heart, and embryonic neural tissue. Regression of experimental neoplasia was not observed when the stimulus was discontinued. In field experiments, gill neoplasms developed in oysters, deployed in cages for 30 days at BRH and 36 days at a BRH dredge material disposal area in Central Long Island Sound, and kidney and gastrointestinal ...

British Library Electronic Table of Contents (United Kingdom)

The combination of functional and morphological imaging technologies such as positron emission tomography (PET) and X-ray computed tomography (CT) has shown its value in the clinical and preclinical field. However, CT provides only very limited soft-tissue contrast and exposes the examined patient or laboratory animal to a high X-ray radiation dose. In comparison to CT, magnetic resonance tomography (MRI) provides excellent soft-tissue contrast and allows for nuclear magnetic resonance spectroscopy (NMRS) or functional MRI (fMRI). Thus, the combination of PET and MRI has been pursued for several years. First approaches have succeeded using conventional photo multiplier tube (PMT) technology together with light fibers to transfer scintillation light away from the high magnetic field. Latest...

International Nuclear Information System (INIS)

Denting phenomenon as experienced in PWR steam generators has been investigated in the laboratory of Monel-400 tubes and C-steel baffles combination. Isothermal corrosion tests have been carried out by exposing capsules, containing a crevice between Monel-400 tubes and C-steel plugs, in plausible corrodents at 300"0C. Results indicated that the denting phenomenon is strongly influenced by the chloride content in the solution. In addition, it is a time dependent process. Stress exerted on the tubes by the growth of corrosion product on the outside surface of C-steel plugs are enough to deform the Monel tubes. The results have been discussed on the basis of accelerated corrosion of C-steel by hydrolyzable metal chlorides. (author).

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In an attempt to overcome inadequacies perceived in the approach to providing energy to village communities using the conventional Khadi and Village Industries Commission biogas plant as well as the Janata model, a biogas digester has been developed suitable for a farmer having only one hectare of land. The information on gas yields and other data from a variety of substrates in a laboratory digester are presented. The digester itself consists of a chamber underground into which the influent flows through a channel. Gas is collected in a dome which constitutes the upper part of the digestion chamber and is maintained under pressure by water. The dome can be made of any suitable material such as plastic, ferrocement and brick and mortar. The upper part of the chamber itself is exposed to sun light which enhances microbial growth. Water which surrounds the dome ensures a minimum of temperature variation. 3 references.

British Library Electronic Table of Contents (United Kingdom)

Isolation of functional and intact mitochondria from solid tissue is crucial for studies that focus on the elucidation of normal mitochondrial physiology and/or mitochondrial dysfunction in conditions such as aging, diabetes, and cancer. There is growing recognition of the importance of mitochondria both as targets for drug development and as off-target mediators of drug side effects. Unfortunately, mitochondrial isolation from tissue is generally carried out using homogenizer-based methods that require extensive operator experience to obtain reproducible high-quality preparations. These methods limit dissemination, impede scale-up, and contribute to difficulties in reproducing experimental results over time and across laboratories. Here we describe semiautomated methods to disrupt tissue ...

KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

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KoreaScience (Korea)

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KoreaScience (Korea)

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Science.gov (United States)

Endothelial dysfunction and increased platelet aggregation may be involved in the pathogenesis of normal tissue radiation toxicity. This study assessed clopidogrel, an inhibitor of ADP-induced platelet aggregation, as a modulator of intestinal radiation injury (radiation enteropathy). Rat small intestine was exposed to 21 Gy X-radiation. Clopidogrel (20 mg/kg/day) or vehicle was administered from 2 days before to 10 days after irradiation. Structural radiation injury, neutrophil infiltration, smooth muscle cell proliferation, collagen content, and TGF-beta1 expression were assessed 2 weeks (early phase) and 26 weeks (delayed phase) after irradiation, using quantitative histology and immunohistochemistry, morphometry, and real-time fluorogenic probe RT-PCR. Irradiated intestine exhibited significant histopathologic injury, reduced mucosal surface area, vascular sclerosis, intestinal wall fibrosis, increased collagen content, and increased ...

Energy Technology Data Exchange (ETDEWEB)

The hypothesis that accumulation against sizable chemical gradients of free (non-phosphorylated) 2-deoxy-D-glucose (2dGlc) in isolated rat adipocytes results from an intracellular compartmentation of free hexose was investigated. Cells exposed to 20 ..mu..g/ml digitonin for 10' demonstrated an increased plasma membrane permeability indexed by increased L-glucose entry rates and cellular (presumably cytosolic) protein and K/sup +/ loss. Functional integrity of intracellular organelles was indicated by the ability of the cells to support ATP-driven /sup 45/Ca/sup 2 +/-uptake. Equilibrium 3-O-methylglucose (3-O-MG, a non-accumulated hexose) levels were unaffected. These data suggest a specific permeabilizing action of digitonin at the plasma membrane having no effect on intracellular organelles or passively distributed solutes. Upon addition of digitonin, free 2dGlc fell from 66.5 +/- 8.9 to 7.4 +/- 2.3 pmol/10/sup 5/ cells, a value not ...

International Nuclear Information System (INIS)

The gender-specific expression pattern of aromatase and 5alpha-reductases (5alpha-R) during brain development provides neurons the right amount of estradiol and DHT to induce a dimorphic organization of the structure. Polychlorinated biphenyls (PCBs) are endocrine disruptive pollutants; exposure to PCBs through placental transfer and breast-feeding may adversely affect the organizational action of sex steroid, resulting in long-term alteration of reproductive neuroendocrinology. The study was aimed at: a) evaluating the hypothalamic expression of aromatase, 5alpha-R1 and 5alpha-R2 in fetuses (GD20), infant (PN12), weaning (PN21) and young adult (PN60) male and female rats exposed to PCBs during development; b) correlating these parameters with the time of testicular descent, puberty onset, estrous cyclicity and copulatory behavior; c) evaluating possible alterations of some non reproductive behaviors (locomotion, learning and memory, ...

Energy Technology Data Exchange (ETDEWEB)

Microbes have been isolated and identified from spent nuclear fuel storage pools at the Idaho National Engineering and Environmental Laboratory (INEEL). Included among these are Corynebacterium aquaticum, Pseudomonas putida, Comamonas acidovorans, Gluconobacter cerinus, Micrococcus diversus, Rhodococcus rhodochrous, and two strains of sulfate-reducing bacteria (SRB). We examined the sensitivity of these microbes to a variety of total exposures of radiation generated by a 6-MeV linear accelerator (LINAC). The advantage of using a LINAC is that it provides a relatively quick screen of radiation tolerance. In the first set of experiments, we exposed each of the aforementioned microbes along with four additional microbes, pseudomonas aeruginosa, Micrococcus luteus, Escherchia coli, and Deinococcus radiodurans to exposures of 5 x 10{sup 3} and 6 x 10{sup 4} rad. All microbial specimens withstood the lower exposure with little or no reduction in cell ...

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The emission isolation flux chamber (EIFC) methodology was applied to Superfund investigations at the Lawrence Livermore National Laboratory Site 300 to determine if on-site workers were exposed to VOCs volatilizing from the subsurface and what, if any, health risks could be attributed to the inhalation of the VOCs volatilizing from the subsurface. During July and August of 1996, twenty, eighteen, and twenty six VOC soil vapor flux samples were collected in the Building 830, 832, and 854 areas, respectively using EIFCS. The VOC concentrations in the vapor samples were used to calculate soil flux rates which were used as input into an air dispersion model to calculate ambient air exposure-point concentrations. The exposure-point concentrations were compared to EPA Region IX Preliminary Remediation Goals (PRGs). Buildings 830 and 832 exposure-point concentrations were less then the PRGs therefore no cancer risks were calculated. The cancer risks ...

UK PubMed Central (United Kingdom)

1. In normal rats and rats with bladder hypertrophy secondary to outflow obstruction, undergoing continuous cytometry, we examined the responses to the selective alpha 1-adrenoceptor antagonist doxazosin...Full Text Available

UK PubMed Central (United Kingdom)

Alterations in basement membrane components, notably proteoglycans, in a rat model of polycystic kidney disease have been investigated. Rats were fed phenol II (2-amino-4-hydroxyphenyl-5-phenyl thiazole)...Full Text Available

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BackgroundCompared to outbred Sprague Dawley (SD) rats, inbred Brown Norway (BN) rats exhibit less prepulse inhibition of startle (PPI) at long prepulse intervals,...Full Text Available

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This paper presents results of a laboratory and field study of naphthenic acid corrosion and the development of an effective chemical inhibitor for this type of corrosive attack. In the laboratory corrosion test, which involved 20 hour weight loss measurements in high flash solvent with a total acid number (TAN) of 16 mg KOH/gm at a temperature of 600 F (316 C), blank corrosion rates averaged 140 to 150 mpy (3.56 to 3.81 mm/y). Inhibited rates averaged about 10 to 12 mpy (0.254 to 0.305 mm/y). The field test was carried out on a heavy vacuum gas oil (HVGO) stream at 550 F (288 C) . Blanks varied from a high of 425 mpy (10.79 mm/y) for a 24 hour test to a low of about 100 mpy (2.54 mm/y) for a 150 hour test. Both electrical resistance (ER) probes and weight loss coupons showed corrosion rates below 5 mpy (0.127 mm/y) as long as they were adequately passivated. Passivation consisted of exposing the coupons to a high inhibitor ...

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Erythrocytes serve as reservoirs for cis- and trans-epoxyeicosatrienoic acids (EETs). Incubation of rat red blood cells (RBCs) with cis- and...Full Text Available

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The concentration of apolipoproteins was measured by quantitative immunoelectrophoresis in rat serum, in the lipoprotein-free ultracentrifugal fraction (density greater than 1.21) of serum, and in renal...Full Text Available

International Nuclear Information System (INIS)

The Nuclear Regulatory Commission (NRC), working with the National Institute of Standards and Technology (NIST), Pacific Northwest National Laboratory (PNNL), and the National Transportation Safety Board (NTSB), performed analyses to predict the response of various spent fuel transportation cask designs when exposed to a fire similar to that which occurred in the Howard Street railroad tunnel in downtown Baltimore, Maryland on July 18, 2001. The thermal performance of three different spent fuel cask designs (HOLTEC HI-STAR 100, TransNuclear TN-68, and NAC-LWT) was evaluated with the ANSYSR and COBRA-SFS analysis codes, utilizing boundary conditions for the tunnel fire obtained using NIST's Fire Dynamics Simulator (FDS) code. NRC Staff evaluated the potential for a release of radioactive material from each of the three transportation casks analyzed for the Baltimore tunnel fire scenario. The results of these analyses are described in detail in ...

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The feasibility of using three different solid fuels in chemical-looping combustion (CLC) has been investigated using NiO as oxygen carrier. A laboratory fluidized-bed reactor system for solid fuel was used, simulating a chemical-looping combustion system by exposing the sample to alternating reducing and oxidizing conditions. In each reducing phase 0.2g of fuel was added to the reactor containing 20g oxygen carrier. The experiments were performed at 970{sup o}C. Compared to previously published results with other oxygen carriers the reactivity of the used Ni-particles was considerably lower for the high-sulphur fuel and higher for the low-sulphur fuel. Much more unconverted CO was released and the fuel conversion was much slower for high-sulphur fuel such as petroleum coke, suggesting that the nickel-based oxygen carrier was deactivated by the presence of sulphur. The NiO particles also showed good reactivity with methane and a syngas mixture ...

International Nuclear Information System (INIS)

The combination of functional and morphological imaging technologies such as positron emission tomography (PET) and X-ray computed tomography (CT) has shown its value in the clinical and preclinical field. However, CT provides only very limited soft-tissue contrast and exposes the examined patient or laboratory animal to a high X-ray radiation dose. In comparison to CT, magnetic resonance tomography (MRI) provides excellent soft-tissue contrast and allows for nuclear magnetic resonance spectroscopy (NMRS) or functional MRI (fMRI). Thus, the combination of PET and MRI has been pursued for several years. First approaches have succeeded using conventional photo multiplier tube (PMT) technology together with light fibers to transfer scintillation light away from the high magnetic field. Latest PET/MRI developments use solid-state light detectors that can be operated even at high magnetic fields. Initial pilot studies with prototype animal PET/MRI ...

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Cadmium is a toxic, non-essential heavy metal inhibiting numerous enzymes with functional sulfhydryl groups. Among the animals, aquatic organisms are most sensitive to heavy metals. Various aspects of toxic effects of cadmium pollution on fishes have been extensively reviewed. Survey of literature reveals that relatively few attempts have been made on the various aspects of cadmium toxicity in crustaceans and these studies were mainly devoted to marine forms. The freshwater crustaceans, particularly the freshwater field crab, Barytelphusa guerini, received less attention. This crab forms one of the major components of the paddy field ecosystem and has an edible importance among local populations. Apart from this, these crabs are easily available, maintainable in the laboratory and data obtained in this study can be extrapolated to other crustaceans. The present study reports the influence of cadmium on certain aspects of carbohydrate metabolism in the tissues of ...

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A test methodology for measuring temperature, impedance, pH, and electrochemical potential distributions within a sludge-packed tube support plate crevice in a laboratory test is described. The method successfully showed that there were large concentration gradients between the tube and tube support plate sides of the crevice. The testing also showed that strong bases concentrated more effectively than strong acids, and that the crevice pH, when exposed to seawater-based solutions, increased with increasing superheat and decreasing bulk concentration. The large variations in the crevice chemistry observed under heat transfer were eliminated upon shutdown. These new test data suggest that it might be beneficial to evaluate the variation in the extent of stress corrosion cracking with tube support plate elevation found in some steam generators in light of local chemistry changes, as well as the variation in tubing temperature. Because of the ...

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ACRO, a NGO equipped with a laboratory to measure radioactivity, runs the Citizen Watchdog of Radioactivity in the Environment. Involving many volunteers, it monitors regularly the French coast of the Channel and many rivers of the North half of France. It also makes investigations in other places. Such an action is aimed to supplement the official monitoring, not to replace it, in order to answer to the worries of the population. This monitoring shows that some radioelements, such as iodine 129, cobalt 60, tritium, etc. released in the environment by nuclear facilities can be detected on very large areas. Carbon 14 was detected up to almost 4 times the background in vegetables around the reprocessing plant of La Hague. ACRO also sits in many official committees to transmit the point of view of the populations exposed to the radioactive pollution. It is lobbying for a decrease of the release authorization, especially for the elements that are ...

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Twenty-four male weanling rats were fed either copper-adequate or -deficient diets until 9 or 11 weeks of age. Deficient rat hearts had increased mitochondria: myofibril compared to adequate rats. Eleven week old deficient rat hearts had decreased mitochondria: myofibril as the hearts increased in weight, but the larger hearts had greater myofibril volume densities. Cardiac mitochondria of deficient rats appeared vacuolated with fragmented cristae and translucent matrix. Valves from copper deficient rats appeared to have less connective tissue and were fragmented in areas. For deficient rats, heart:body weights of 9 wk old rats were negatively correlated with bicuspid valve pathology scores, whereas tricuspid valve scores from 11 wk old rats were negatively correlated with myofibril volume densities. ...

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PMID:2042311

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The myocardial infarct induced by isoproterenol in spontaneously hypertensive rats accumulates higher activities of /sup 99/sup(m)Tc-PM tetracycline compared with the cardiac infarct in normotensive rats caused by the same method. The isoproterenol model of the myocardial necrosis was induced in intact rats without opening the thorax and is a convenient method for experimental radioisotope studies.

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The present study was designed to determine the exercise intensity equivalent to the metabolic aerobic/anaerobic transition of alloxan diabetic rats, through lactate minimum test (LMT), and to evaluate the effects of swimming exercise at this intensity (LM) on the glucose and protein metabolism of these animals. Adult male Wistar rats received alloxan (SD, alloxan-injected rats that remained sedentary) intravenously (30 mg kg?1 body weight) for diabetes induction. As controls (SC, vehicle-injected rats that remained sedentary), vehicle-injected rats were utilized. Two weeks later, the animals were submitted to oral glucose tolerance test (oGTT) and LMT. After the tests, some of the animals were submitted to swimming exercise training [TC (vehicle-injected rats that performed a 6-week exerc...

International Nuclear Information System (INIS)

To examine the hormonal regulation of the ATP-dependent Ca"2"+ pump in the kidneys, the ATP-dependent Ca"2"+ uptake by the basolateral membrane vesicles in the renal cortex was measured using radioactive calcium ("4"5Ca"2"+) in rats with vitamin D deficiency or rats undergoing thyroparathyroidectomy. The V_m_a_x of the Ca"2"+ pump activity was increased not only by administering calcitriol, but also by normalizing the serum calcium level in vitamin D-deficient rats. PTH suppressed the Ca"2"+ pump activity in normocalcemic vitamin D-deficient rats. Thyroparathyroidectomy did not affect the Ca"2"+ pump activity in the kidneys of normal rats. It was concluded that the ATP-dependent Ca"2"+ pump activity was depressed by secondary hyperparathyroidism in vitamin D-deficient rats. (author).

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Potential maximum radiation dose rates were calculated for the former Alba Craft Laboratory site in Oxford, Ohio, which was involved in machining of uranium metal in the 1950s for the U.S. atomic energy program. The site is not currently being used. The residual radioactive material guidelines (RESRAD) computer code, which implements the methodology described in the US Department of Energy`s (DOE`s) manual for establishing residual radioactive material guidelines, was sued in this evaluation. Three potential land use scenarios were considered for the former Alba Craft site; the scenarios vary with regard to the type of site use, time spent at the site by the exposed individual, and sources of food consumed. Scenario A (a possible land use scenario) assumed industrial use of the site; Scenario B (a likely future land use scenario) assumed residential use of the site; and Scenario C (a possible but unlikely land use scenario) assumed the presence ...

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Region Lombardia has carried out a radon gas monitoring survey on its territory to localize radon prone areas as by law 241/00 enacted. To plan the survey, the Lombardia territory has been divided into two different types according to the morphology as well as the presence of a substratum of rock. The area with hills and mountains has been investigated with more attention compared to the plain because we can assume higher variability in radon concentration distribution due to the geological and morphological characteristics. The territory subdivision was based on the standard grid.. of the techniregional cartography (8 x 5 km). To perform radon indoor concentration measurements about 3600 measuring points were selected. They are located at the ground floor of buildings with the characteristics to ensure the tests are representative and comparable. It has also been taken into account evaluations done with previous surveys in accordance with the defined specification of the sites. The ...

UK PubMed Central (United Kingdom)

We have established a reliable method to induce invasive and non-invasive carcinomas in the heterotopically transplanted urinary bladder of rats by repeated injection of N-methyl-N-nitrosourea (MNU),...Full Text Available

UK PubMed Central (United Kingdom)

Subcellular-fractionation techniques were used to characterize the endocytic pathway followed by ricin in rat liver in vivo and tentatively identify the site(s) at which the ricin interchain disulphide...Full Text Available

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1. Proteolytic enzyme activities were examined in the pancreas of zinc-deficient and control rats. 2. No change was detected in trypsin-plus-chymotrypsin activity. 3. Carboxypeptidase activity was...Full Text Available

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Treatment of male rat pups from five to 34 days of age with dihydrotestosterone or 5 alpha-androstane-3 alpha, 17 beta-diol, resulted in reduced testicular size at 35 days of age. This appeared to be...Full Text Available

UK PubMed Central (United Kingdom)

Previous studies have shown that salicylates and protein-calorie malnutrition independently compromise maturation and growth of infants. In the present study, pregnant rats were fed normal-and low-protein...Full Text Available

UK PubMed Central (United Kingdom)

1. The uptake and esterification to trigylceride of oleic acid in micellar form was studied in rat intestine in vitro. Sacs of the upper half of the everted intestine taken from bile...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo investigate the different components of full-field flash electroretinogram (ERG) responses in adult albino and pigmented rats at various time intervals following optic...Full Text Available

UK PubMed Central (United Kingdom)

The specific white matter location of all the spinal pathways conveying penile input to the rostral medulla is not known. Our previous studies using rats demonstrated the loss of low but not high threshold...Full Text Available

UK PubMed Central (United Kingdom)

In anaesthetized rats, extracellular and intracellular recordings were taken from 106 respiratory neurones in the intermediate region of the nucleus ambiguus. We observed unprovoked shortening of expiratory...Full Text Available

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1. Rates and rate coefficients of glucose utilization and replacement were determined with [5-3H]- and [U-14C]-glucose in rats starved for 24h, either conscious or under halothane anaesthesia, in a...Full Text Available

UK PubMed Central (United Kingdom)

Thiobenzamide (TB) is a potent hepatotoxin in rats, causing dose-dependent hyperbilirubinemia, steatosis, and centrolobular necrosis. These effects arise subsequent to and appear to result from...Full Text Available

UK PubMed Central (United Kingdom)

After treatment with NN-di[14C]methylnitrosamine, samples of DNA were isolated from rat livers by a conventional phenol procedure and examined for the presence of phosphotriesters. A method of capable...Full Text Available

UK PubMed Central (United Kingdom)

Neonatal bacterial infection in rats alters the responses to a variety of subsequent challenges later in life. Here we explored the effects of neonatal bacterial infection on a subsequent drug...Full Text Available

UK PubMed Central (United Kingdom)

The goal of this study was to determine if the exaggerated morphine-induced conditioned place preference (CPP) response seen in adult rats after preweanling methylphenidate exposure is unique...Full Text Available

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To determine the mechanism of the cardiac dilatation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed chemically and morphologically. TG was...Full Text Available

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Place fields of hippocampal pyramidal cells expand asymmetrically when adult rats repeatedly follow the same route. This behaviorally-induced expression of neuronal plasticity utilizes an NMDA_R-dependent,...Full Text Available

International Nuclear Information System (INIS)

Ruthenium-106 administered to newborn rats and swine was incorporated into the epithelium of the lower small intestine and retained there for a few weeks after gavage; the stomach and small bowel of guinea pigs incorporated "1"0"6Ru but did not retain it.

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Aim:The effect of Tualang honey on wound healing in bacterial contaminated full-thickness burn wounds was evaluated in 36 male Sprague Dawley rats.Materials...Full Text Available

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Neonatal exposure to diethylstilbestrol (DES) can alter the structure of the testicular excurrent ducts in rats. We characterized these changes according to dose and time posttreatment and established...Full Text Available

UK PubMed Central (United Kingdom)

AIMS:This study aimed to determine the effect of 50 days of forced swimming stress on fertilization capacity of rat and subsequent offspring quality.SETTING...Full Text Available

UK PubMed Central (United Kingdom)

In rats, damage to neuronal populations in some brain regions occurs in response to neonatal alcohol exposure coinciding with the period of rapid brain growth. These alcohol-induced defects...Full Text Available

UK PubMed Central (United Kingdom)

This study examined the genetic basis of hypertension and renal disease in Dahl SS/Mcwi (Dahl Salt-Sensitive) rats using a complete chromosome substitution panel of consomic rats in which each of the...Full Text Available

UK PubMed Central (United Kingdom)

1. Paired or single recordings of paraventricular and/or supraoptic oxytocin cells at the beginning of suckling in urethane-anaesthetized rats enabled us to study cell recruitment and compare the characteristics...Full Text Available

UK PubMed Central (United Kingdom)

A rhabdomyosarcoma in a WAG/Rij rat with capacity for colony growth after tumour excision and enzymatic dissociation has been used to study response to high and low LET radiation. End points are tumor...Full Text Available

UK PubMed Central (United Kingdom)

Mice injected with rat erythrocytes developed anti-erythrocyte autoantibodies which reached a plateau at 4-12 weeks, then gradually declined until at about 24 weeks the majority of mice were negative....Full Text Available

UK PubMed Central (United Kingdom)

The cyclic AMP content of acini, freshly prepared from mammary tissue of lactating rats, was measured during incubation in vitro. Neither adrenergic agonists nor cyclic AMP phosphodiesterase inhibitors...Full Text Available

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The control of piece size in ruptured rocks in coal sections is important as part of the general problem of increasing efficiency in the technology of open-pit mining operations. An attempt is made in this paper to estimate the rupture capacity of exposed rocks in coal sections based on a set of physicomechanical property indicators, using the methods of multidimensional statistical analysis. It was established that all the parameters for the physiocomechanical properties of the exposed rocks are highly correlated. The method proposed for determining criteria for explosive capacity is of interest in developing criteria for the destruction capacity (drillability, excavation capacity, etc.) in the exposed rocks of coal sections which are characterized by high variation in physical and mechanical properties.

Science.gov (United States)

The three mammalian transforming growth factor (TGF)-? isoforms (TGF-?1, TGF-?2, and TGF-?3) differ in their putative roles in radiation-induced fibrosis in intestine and other organs. Furthermore, tissue specificity of TGF-? action may result from temporal or spatial changes in production and/or activation. The present study examined shifts in the cell types expressing TGF-? mRNA relative to TGF-? immunoreactivity and histopathological injury during radiation enteropathy development. A 4-cm loop of rat small intestine was locally exposed to 0, 12, or 21-Gy single doses of x-irradiation. Sham-irradiated and irradiated intestine were procured 2 and 26 weeks after irradiation. Cells expressing the TGF-?1, TGF-?2, or TGF-?3 transcripts were identified by in situ hybridization with digoxigenin-labeled riboprobes. Intestinal wall TGF-? immunoreactivity was measured using computerized image analysis, and structural radiation injury was assessed by ...

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(1972). Denmark Ekelund, L. Goethlin, J. Henrikson, H. Letter-to-the-

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The experiment was designed to study the effects of sodium pentobarbital on behavioral thermoregulation in rats and mice. Male Sprague-Dawley rats were given intraperitoneal (i.p.) injections of sodium pentobarbital in doses of 0, 1, 5, 10 or 15 mg/kg and male CBA/J mice were giv...

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The distribution of Lipiodol in the liver and lungs following arterial or portal injection was studied in normal (n=55) and cirrhotic rats (n=20). Using magnified xeroradiography and radioisotope labeled tracers, it was found that Lipiodol was deposited mainly in the liver and lung after either arterial or portal administration. In control rats after arterial injection, deposits in the lung peaked after 2 hours and gradually declined over 48 hours; whereas after portal injection, the deposit steadily increased for 48 hours. Twenty-five percent of cirrhotic rats demonstrated a Lipiodol-induced miliary pattern in the lung. An increased number of portosystemic shunts in cirrhotic rats was also noted. These results suggest that cirrhosis of the liver may be a potential risk factor for developing pulmonary complications after Lipiodol administration. (orig.).

British Library Electronic Table of Contents (United Kingdom)

The purpose of this study was to investigate whether the expression of specific genes in peripheral blood can be used as surrogate marker(s) to detect and distinguish target organ toxicity induced by chemicals in rats. Rats were intraperitoneally administered a single, acute dose of a well-established hepatotoxic (acetaminophen) or a neurotoxic (methyl parathion) chemical. Administration of acetaminophen (AP) in the rats resulted in hepatotoxicity as evidenced from elevated blood transaminase activities. Similarly, administration of methyl parathion (MP) resulted in neurotoxicity in the rats as evidenced from the inhibition of acetyl cholinesterase activity in their blood. Administration of either chemical also resulted in mild hematotoxicity in the rats. Microarray analysis of the global ...

International Nuclear Information System (INIS)

Author.Field, laboratory and market studies are a must for proper evaluation of natural resources for the mineral industry of lebanon. Sites selectively convenient to the existing major Lebanese ceramics industry centered in the Beqa'a region, were investigated as to their geology, geography and economic character. The raw materials are shales, mud stones, siltstones and other argillaceous rocks of Jurassic to Cretaceous age coming from selective sites in south and central Lebanon. The finished products include wall, floor, roofing tiles, pipes, sanitary ware, pottery and brick specimens. Differential thermal analysis, scanning electron microscopy, firing and physico-chemical tests and analyses characterized the raw materials into two major groups: the suitable are siliceous argillaceous rocks and unsuitable calcareous argillaceous rocks. The suitable group is divided into two varieties. The first is dominantly a disordered Kaolinite with low drying and firing ...

International Nuclear Information System (INIS)

A preliminary geologic investigation was conducted to determine if Triassic sedimentary rocks of the Sanford basin and Colon cross structure in North Carolina are favorable hosts for uranium deposits. Rocks of adjacent Carolina slate belt were also examined as a potential source of uranium. On the basis of favorability criteria for sandstone-type uranium deposits, and geologic and geophysical investigations of the study area, the most favorable sites for further investigation are (1) at the contacts between the Pekin and Cumnock and between the Pekin and Sanford Formations near the Colon cross structure and (2) at the base of the Jonesboro fault, which lies below the Sanford Formation, northwest of Sanford. The highly weathered granites southeast of the Jonesboro fault were a source of the detritus deposited on the cross structure and may have been a primary source of uranium. Uranium leached from the coarse sediment (Pekin Formation) of the cross structure may have been transported ...

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Nature of tube degradation was studied in support of horizontal steam generator lifetime calculations. Experiments were carried out to evaluate the resistance to environmentally assisted cracking (EAC) of steam generator tubes during operation. Estimations of the incubation period for crack initiation and the threshold K value, K(ISCC), and the crack growth rate were made to predict evolution of damage in tube walls. Experimental results were compared with in-service inspections experience. The paper summarizes results of experiments of C ring specimen for the initiation testing and results of SENT (single edge notch tensile) specimen for the crack growth rate (CGR) testing. The specimens were exposed to concentrated environments at elevated temperatures simulating crevice environments in secondary side crevices in horizontal steam generators. The results show that material of SG (steam generator) tubes is sensitive to transgranular environmentally assisted ...

International Nuclear Information System (INIS)

The operation and proper handling of equipment for measuring EMR-300 electromagnetic waves are studied and apply that knowledge to determine which areas of the metropolitan area are mostly affected by exposure to the emission of radiation. This team is able to measure magnetic field strength, electric field strength and power density, also can measure the most important parameters in a simple manner. International standards provide maximum values for these parameters that limit human exposure to such radiation. These standards are based on epidemiological several and laboratory that have been carried out in order to determine in which circumstances a biological entity is exposed to a level of radiation that can cause harm to their health. It focuses on measuring the level of radiation in certain areas of interest, which were chosen because are areas with high population density and also in proximity to antennas that emit electromagnetic waves. ...

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Whole-body retention and excretion following a single oral dose of radiolabeled lead ("2"0"3Pb) in chronically lead-exposed pregnant BK:W mice were examined over 10-13 days. This was compared with values in similarly treated nonpregnant females and in ip injected females. Whole-body and bone retention were greater in injected than in orally dosed nonpregnant females; gastrointestinal absorption was estimated from this difference. Whole-body retention in the pups was measured at birth and at the end of the experiment. Whole-body retentions in pregnant females and in their pups at birth were significantly raised after treatment at Gestational Day 17, but not after treatment at Gestational Day 11, 14, 20, 23, or 26. Pup body burdens at birth were significantly and positively correlated with maternal retention. Measurement of radioactivity in bone, kidney, brain, heart, and liver of adults at the end of the experiments showed significantly increased levels in bone and ...

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High energy physics facilities must monitor the radiation doses received by their personnel. This monitoring can only be effective if the radiation detection devices can be calibrated with a good degree of accuracy. Radiation fields are usually composed of several types of radiation, including gamma rays, beta radiation, neutrons, etc. The neutron detection instruments respond not only to the neutrons coming directly from the source but also those scattered from the floor, walls, and ceiling. The amount of neutron scattering varies from site to site depending on the construction materials and layout of the building. The purpose of this study was to determine the scattered neutron fraction in the central volume of the calibration mezzanine of the Radiation Physics Calibration Facility (RPCF) at the Fermi National Accelerator Laboratory (Fermilab). At Fermilab, radiation workers dosimeters use CR39 for neutron detection, which are sent to an outside vendor for ...

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A comparison of the concentration-response effects of inhaled ozone (O/sub 3/) in different species of laboratory animals was made in order to better understand the influence of the choice of species in inhalation studies of this gas. The effect of 4-hour exposure to ozone (O/sub 3/) at concentrations of 0.0, 0.2, 0.5, 1.0, and 2.0 ppm was determined in rabbits, guinea pigs, rats, hamsters and mice. Lavage fluid protein (LFP) accumulation 18 hr after exposure was used as the indicator of O/sub 3/-induced pulmonary edema. All species had similar basal levels of LFP (250-350 ug/ml) when a volume of saline which approximated the total lung capacity was used for lavage of the collapsed lungs. Exponential dose-response curves were seen in all species except guinea pigs, which showed significant increases in LFP at low O/sub 3/ concentrations (0.2 ppm) and a leveling off of response at the higher O/sub 3/ levels. Other species usually showed ...

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... Tactical Electronic Warfare Division (Code 5700) Visualization Laboratory Transportable step frequency radar Vehicle development laboratory ...

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Somatogenic hormones play an important role in regulation of receptors for prolactin (PRL) and estrogen. Plerocercoids of the tapeworm, S. mansonoides produce a factor which mimics some, but not all of the actions reported for GH. Intact female rats were subjected to a constant infusion of plerocercoid growth factor (PGF) via a subcutaneous infection for two weeks to determine if PGF influences receptors for PRL, GH or estradiol. The rate of weight gain in the PGF-treated rats was accelerated in spite of a marked reduction in serum GH. Partially-purified PGF specifically displaced [125I]hGH from rat liver receptors but microsomes prepared from rats treated with PGF specifically bound significantly less [125I]hGH than microsomes from control rats. The reduction in [125I]hGH binding was not due to occupancy or to a change in affinity but to a suppression in receptor concentration. ...

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Systemic and splanchnic hemodynamics of the chronic bile duct-ligated rat were characterized by radioactive microspheres. Conscious and pentobarbital sodium-anesthetized, bile duct-ligated and sham-operated rats had cardiac output and regional organ blood flows determined. The conscious bile duct-ligated rat compared with the sham-operated showed a hyperdynamic circulation with an increased cardiac output and portal tributary blood flow. Pentobarbital sodium anesthesia induced marked hemodynamic changes in both sham-operated and bile duct-ligated rats. The latter group was especially sensitive to its effects; thus, comparison of cardiac output and portal tributary blood flow between anesthetized bile duct-ligated and sham-operated rats showed no significant differences. The authors conclude that the rat with cirrhosis due to chronic bile duct ligation is an ...

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The concentration of trace elements in brain sections was measured by synchrotron radiation X-ray fluorescence. The relative concentration was calculated by means of the normalization of Compton scattering intensity approximately 22 keV, after the normalization for collecting time of X-ray spectrum and the counting of the ion chamber, and subtracting the contribution of the polycarbonate film for supporting sample. Furthermore, the statistical evaluation of the element distribution in various regions of the brain sections of the 20-day-old rats was tested. For investigating the distribution of elements in the brain of iodine deficient rats, Wistar rats were fed with iodine deficient diet and deionized water (ID group). The rats were fed the same iodine deficient diet, but drank KIO_3 solution as control (CT group). The results showed that the contents of calcium (Ca) in thalamus (TH) and copper (Cu) and ...

International Nuclear Information System (INIS)

Among in uterus exposed A-bomb survivors, fetal week is the most important factor to clarify the effects of A-bomb radiation on developmental process of the fetal brain. The study population of in utero exposed A-bomb survivors has first been established in 1953 in Hiroshima and in 1955 in Nagasaki. According to the estimated DS86 uterus absorption doses, fetal absorption doses obtained from the uterus doses, and intelligence quotient. Various studies on brain damage, including microcephaly, have been undertaken among in uterus exposed A-bomb survivors. Brain development has been shown to be affected during the fetal weeks 8-15 and 16-25. A review of the literature has revealed that 80% of the children with mental retardation and 15 of 18 cases of microcephaly (83%) were exposed in utero during the fetal week 8-15. Among children exposed at the fetal weeks 8-15 and 16-25, average ...

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Homology analyses of the protein sequences of chicken liver and rat mammary gland fatty acid synthases were carried out. The amino acid sequences of the chicken and rat enzymes are 67% identical. If conservative substitutions are allowed, 78% of the amino acids are matched. A region of low homologies exists between the functional domains, in particular around amino acid residues 1059-1264 of the chicken enzyme. Homologies between the active sites of chicken and rat and of chicken and yeast enzymes have been analyzed by an alignment method. A high degree of homology exists between the active sites of the chicken and rat enzymes. However, the chicken and yeast enzymes show a lower degree of homology. The DADPH-binding dinucleotide folds of the {beta}-ketoacyl reductase and the enoyl reductase sites were identified by comparison with a known consensus sequence for the DADP- and FAD-binding dinucleotide ...

International Nuclear Information System (INIS)

The bioavailability of lead was studied in rats fed various baby foods (Babymix-turkey, Babymix-vegetables, Frutolino-fruit, Frutamix-bananas, Babyron-S-26, Truefood), cow's milk, bread, liver and standard rat diet. Lead absorption was determined by measuring the whole body retention of "2"0"3Pb 6 days after a single oral application. Highest absorption values ranging from 17 to 20% were obtained in animals fed cow's milk and fruit foods. Rats on other human diets absorbed between 3 and 8% of the radioactive lead dose. Only in animals on rat diet lead absorption was below 1%. It is concluded that rats fed human diets show absorption values similar to those in humans. This might indicate that the bioavailability of lead is primarily dependent on dietary habits. This experimental model, if confirmed by further work, might be useful for obtaining preliminary data on the bioavailability ...

International Nuclear Information System (INIS)

Rats and guinea pigs were fed "2"3"8Pu either biologically incorporated into alfalfa (by growth of the plant on soil containing Pu) or added as a solution to alfalfa, or were gavaged with a Pu solution. Depending upon the plant material fed, there appeared to be a twofold increase in "2"3"8Pu-gut absorption by the rat and a two- to fourfold increase in the guinea pig as compared with absorption from the Pu solution. The data, though limited and variable, suggest that Pu bound to plant tissue may have higher gut absorptivity than inorganic Pu in both herbivorous and nonherbivorous rodents.

Energy Technology Data Exchange (ETDEWEB)

The report gives general principles of treatment and care of casualties caused by radiation accidents or nuclear explosions.

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A sample of 30 manganese-exposed foundry workers from two Swedish plants were examined with a partly computerized psychological test battery, comprised of 10 performance tests. Performance of the manganese-exposed workers was compared to that of a matched control group of 60 workers. Matching criteria were age, geographical area, type of work, and the results on a test of verbal comprehension. Performance of the exposed workers was inferior to that of the control group on tests of simple reaction time, digit span, and finger tapping. No correlations were found between performance and the present manganese exposure levels or the number of years employed in manganese work. The results seem to indicate that the present exposure standards for manganese, in Sweden 2.5 mg/m3 and in most other countries 5 mg/m3, are not sufficient to protect workers from negative effects on performance capacity.

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No abstract prepared

UK PubMed Central (United Kingdom)

OBJECTIVEAdolescent offspring of women with a history of gestational diabetes (GD) were evaluated for their cardiometabolic risks at a mean age of 15 years.RESEARCH...Full Text Available

Science.gov (United States)

Palladium chloride films have been found to be useful as ... when suitably prepared palladium chlo- ride films are exposed ... Like the palladium chloride ( PdCl2) ...

UK PubMed Central (United Kingdom)

A field study of 89 refrigerator repairmen was carried out to ascertain whether occupational exposure to fluorocarbons induces cardiac arrhythmia. The concentrations of fluorocarbons in the breathing...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A method and apparatus for determining the condition of tissue or otherwise making chemical identifications includes exposing the sample to a light source, and using a synchronous luminescence system to produce a spectrum that can be analyzed for tissue condition.

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These studies were undertaken to assess the effects of increased galactose (v increased glucose) metabolism via the polyol pathway on vascular filtration function in the kidneys, eyes, nerves, and aorta. Quantitative radiolabeled tracer techniques were used to assess glomerular filtration rate (GFR) and regional tissue vascular clearance of plasma 131I-bovine serum albumin (BSA) in five groups of male Sprague-Dawley rats: nondiabetic controls, streptozotocin-diabetic rats, nondiabetic rats fed a 50% galactose diet, diabetic rats treated with sorbinil (an aldose reductase inhibitor), and galactose-fed rats treated with sorbinil. Sorbinil was added to the diet to provide a daily dose of approximately .2 mmol/kg body weight. After 2 months of diabetes or galactose ingestion, albumin clearance was increased twofold to fourfold in the eye (anterior uvea, choroid, and retina), sciatic ...

UK PubMed Central (United Kingdom)

The muscarinic receptor binding of trazodone, a new nontricyclic antidepressant, was compared with established tricyclic antidepressants. The ability to inhibit the binding of [3H]-quinuclidinyl benzilate...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundTacrolimus (FK-506) is an immunosuppressant that binds to a specific immunophilin, resulting in the suppression of the cellular immune response during transplant rejection....Full Text Available

Science.gov (United States)

Serum growth hormone (GH) was suppressed in female rats bearing mammary tumors induced by 7, 12, dimethylbenz(a)anthracene (DMBA) or N-nitrosomethylurea(NMU). Serum GH was suppressed due to treatment with a human GH analog produced by the plerocercoid stage of the tapeworm Spirometra mansonoides. Rats treated with plerocercoid growth factor (PGF) via plerocercoid infection had accelerated growth rates despite marked reductions in GH levels. Approximately two-thirds of the mammary tumors induced by either DMBA or NMU regressed during three weeks of exposure to PGF while most of the control tumors continued to grow. The data support an important regulatory role for GH in growth of mammary tumors in rats. PMID:3019224

British Library Electronic Table of Contents (United Kingdom)

Hypertension is one of the most important modifiable risk factors for cardiovascular and cerebrovascular diseases. We investigated the potential antihypertensive effect of the purple passion fruit peel (PFP) extract, a mixture of bioflavonoids, phenolic acids, and anthocyanins, in spontaneously hypertensive rats and human. A high-performance liquid chromatography analysis was performed to identify the active ingredients of the PFP extract. In a rat liver toxicity assay, no hepatotoxicity was observed after 9 hours incubation in the presence of PFP extract (20 ?g/mL). The PFP extract also revealed hepatoprotection against chloroform (1 mmol/L)-induced liver injury. In the experimental model, 24 spontaneously hypertensive rats were divided into 3 treatment groups for a period of 8weeks: cont...

UK PubMed Central (United Kingdom)

The results of a histological study of normal osteoid tissue in man, the monkey, the dog, and the rat, using thin microtome sections of plastic-embedded undecalcified bone, are described. Osteoid tissue...Full Text Available

International Science & Technology Center (ISTC)

Morphological, Electrophysiological and Behavioral Investigations of the Nervous Tissue Developed from the Embryonic Matrix Zone Cells of the Dorsolateral Walls of Lateral Ventricles, Implanted into the Lesioned Regions of the Adult Rat's Brain

British Library Electronic Table of Contents (United Kingdom)

In several vertebrate classes, the M?ller glia are capable of de-differentiating, proliferating, and acquiring a progenitor-like state in response to acute retinal injury or in response to exogenous growth factors. Our previous study has shown that M?ller cells can be activated and de-differentiated into retinal progenitors during Royal College of Surgeons (RCS) rats' degeneration, although the limited proliferation cannot maintain retinal function. We now report that rat retinal stem cells (rSCs) transplanted into RCS rats slowed the progression of retinal morphological degeneration and prevented the functional disruption. Further, we found that retinal progenitor cells labeled with Chx10 were increased significantly after rSCs transplantation, and most of them are mainly from activated M...

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British Library Electronic Table of Contents (United Kingdom)

Ethnopharmacological relevance: Tong Luo Jiu Nao (TLJN) is a modern Chinese formula based on Traditional Chinese Medicine theory that has been used to treat ischemic cerebral stroke and vascular dementia. TLJN belongs to the ethnopharmacological family of medicines. In this study, we investigated the mechanism of the TLJN effect on Alzheimer's disease (AD). Aim of the study: To investigate the effect of TLJN on b-amyloid-degrading enzymes and learning and memory in the AD rat brain. Materials and methods: AD rats whose disease was induced by Ab25-35 injection into the bilateral hippocampus CA1 region were subjected to intragastric administration of various preparations. The experimental animals were healthy male Sprague-Dawley rats which were randomly divided into normal, sham, model, TLJN...

Energy Technology Data Exchange (ETDEWEB)

The dose-dependent transfer of [sup 203]Pb to milk and uptake in suckling rats and mice during a three-day nursing period was studied. On day 14 of lactation, the dams were administered a single intravenous dose of lead, labelled with [sup 203]Pb, in four or five doses from 0.0005 to 2.0 mg Pb/kg b.wt. There was a linear relationship between Pb levels in plasma and milk of both species. The Pb milk: plasma ratios at 24 hr after administration were 119 and 89 in mice and rats, respectively. At 72 hr the Pb milk: plasma ratio had decreased to 72 in mice and 35 in rats. The tissue levels of lead in the suckling rats and mice were also linearly correlated with lead concentration in milk at 72 hr, showing that milk could be used as an indicator of lead exposure to the suckling offspring. It is concluded that lead is transported into rat and mouse milk to a very high extent and the ...

British Library Electronic Table of Contents (United Kingdom)

To test the hypothesis that transduction of the channelrhodopsin-2 (ChR2) gene, a microbial-type rhodopsin gene, into retinal ganglion cells of genetically blind rats will restore functional vision, we recorded visually evoked potentials and tested the experimental rats for the presence of optomotor responses. The N-terminal fragment of the ChR2 gene was fused to the fluorescent protein Venus and inserted into an adeno-associated virus to make AAV2-ChR2V. AAV2-ChR2V was injected intravitreally into the eyes of 6-month-old dystrophic RCS (rdy/rdy) rats. Visual function was evaluated six weeks after the injection by recording visually evoked potentials (VEPs) and testing optomotor responses. The expression of ChR2V in the retina was investigated histologically. We found that VEPs could not b...

Science.gov (United States)

Oxidative stress is demonstrated to be involved in the pathophysiological mechanism of erectile dysfunction (ED). Quercetin, a potent bioflavonoid, has been reported to have the antioxidant role. In the present study, we examined the effect of quercetin on ED and oxidative stress in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in Sprague-Dawley rats with a single intravenous injection of STZ. The diabetic rats were then randomized to diabetic group and quercetin therapy groups which were treated with quercetin at different doses of 5, 20 and 50mg/kg per day respectively. At the end of the 8th week, erectile function was assessed by measuring the rise in intracavernous pressure (ICP) following cavernous nerve electrostimulation. Superoxide dismutase (SOD) activity, thiobarbituric acid-reacting substance (TBARS) and nitrite and nitrate (NOx) levels were measured in cavernosum tissue. Endothelial NO ...

UK PubMed Central (United Kingdom)

Over the past 10 years, the Peruvian National Tuberculosis (TB) Program, the National Reference Laboratory (NRL), Socios en Salud, and US partners have worked to strengthen the national TB laboratory...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

There is increasing pressure to operate laboratory facilities in environmentally and financially sustainable ways. A key factor in achieving this goal is careful consideration of how energy is used by the buildings' ventilation system, both for conditioning air supplied to the laboratories and the energy used moving air through the building. Traditionally, laboratory energy use is treated as an engineering concern within the scope of the building's overall design and operation. However, this approach limits the involvement of key stakeholders in many important decisions and can lead to unexpected safety concerns for the laboratory's users. We believe that a broad view of the parties affected by a laboratory building's operations is necessary to avoid having the various stakeholders working...

Science.gov (United States)

as manufacturing plants and laboratories, including the Chemical Laboratory at the House of David in Benton Harbor, Michigan. Built in America: Historic Building Buildings Survey/...

Energy Technology Data Exchange (ETDEWEB)

The purpose of this statement of work (SOW) is to establish laboratory analytical criteria and requirements for radioactive airborne emissions measurement sample and/or analysis activities.

Energy Technology Data Exchange (ETDEWEB)

This document details monthly activities at the Savannah River Laboratory. Topics addressed are reactor operation; tritium facilities and production; separation operations; environmental concerns; and waste management. (FI)

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Publications Science Highlights Researcher Profiles Internship Funding to push battery technology from Argonne Laboratory to marketplace Bookmark and Share (Download...

Science.gov (United States)

When an animal is exposed to a sufficient amount of radiation, there will be changes in many organs of the body, and as a result of either the effects in one particular organ or the interaction of effects in several organs, the animal as a whole will show...

International Nuclear Information System (INIS)

Beagle dogs given a single inhalation exposure to "2"3"9Pu(NO_3)_4 are being observed for life-span dose-effect relationships. Over half of the dogs planned for "2"3"9Pu(NO_3)_4 exposure have been exposed and the remaining dogs will be exposed as they reach adult age.

UK PubMed Central (United Kingdom)

In the rat, some phthalates alter sexual differentiation at relatively low dosage levels by altering fetal Leydig cell development and hormone synthesis, thereby inducing abnormalities of the testis,...Full Text Available

UK PubMed Central (United Kingdom)

Metabotropic glutamate receptor 2/3 (mGluR2/3) agonists were shown previously to nonselectively decrease both cocaine- and food-maintained responding in rats. mGluR2 positive allosteric modulators (PAMs)...Full Text Available

International Nuclear Information System (INIS)

Comparison of the embryolethality of monomeric "2"3"9Pu injected at 9 days of gestation demonstrated that the sensitivity of Charles River CD strain was greater than that of Hilltop Wistar rats. Subsequent comparisons showed that rats derived from the Hilltop Fischer strain were more sensitive than the Wistar and, although not directly compared, more sensitive than the CD.

UK PubMed Central (United Kingdom)

1. The induction of long-term potentiation (LTP) was investigated in the rat dentate gyrus in the presence of ryanodine, an agent which is known to selectively bind to the ryanodine receptor (RyR) Ca2+...Full Text Available

UK PubMed Central (United Kingdom)

σ-Receptor (σR) antagonists have been reported to block certain effects of psychostimulant drugs. The present study examined the effects of σR ligands in rats trained to self-administer...Full Text Available

UK PubMed Central (United Kingdom)

In this study, bone mineral density (BMD) of normal (CON), ovariectomized (OVX) and partially nephrectomized (NFR) rats was measured by ³¹P NMR spectroscopy; bone matrix density was...Full Text Available

UK PubMed Central (United Kingdom)

We have shown that addition of exogenous delta-aminolaevulinic acid (ALA) to rat pancreatoma AR4-2J cells in culture leads to the increased production of porphobilinogen (PBG) and the accumulation of...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

A systematic comparison was undertaken to characterize neurotoxic esterase (NTE) from rat and chicken brain in terms of inhibitor sensitivities, pH optima, and molecular weights. Paraoxon titration of phenyl valerate (PV)-hydrolyzing carboxylesterases showed that rat esterases were more sensitive than chicken to paraoxon inhibition at concentrations less than or equal to microM and superimposable with chicken esterases at concentrations of 2.5-1000 microM. Mipafox titration of the paraoxon-resistant esterases at a fixed paraoxon concentration of 100 microM (mipafox concentration: 0-1000 microM) resulted in a mipafox I50 of 7.3 microM for chicken brain NTE and 11.6 microM for rat brain NTE. NTE (i.e., paraoxon-resistant, mipafox-sensitive esterase activity) comprised 80% of chicken and 60% of rat brain paraoxon-resistant activity with the specific activity of chicken brain NTE approximately twice that of ...

UK PubMed Central (United Kingdom)

Intracellular recordings were made from 1022 somatic lumbar dorsal root ganglion (DRG) neurones in anaesthetized adult rats, classified from dorsal root conduction velocities (CVs) as C, Aδ...Full Text Available

UK PubMed Central (United Kingdom)

Whether the lusitropic potential of short-term exercise in aged rats is linked to an augmentation in the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and an alteration in the...Full Text Available

UK PubMed Central (United Kingdom)

1. Using a grease-gap recording technique we have investigated the effects of some antagonists of P2-purinoceptors on the depolarization of the rat isolated superior cervical ganglion evoked by 100...Full Text Available

UK PubMed Central (United Kingdom)

Seventy male Wistar rats were the recipients of labeled small lymphocytes (1.5 X 10(7) each) collected from the peripheral blood of syngeneic donors. The migrating labeled lymphocytes were traced in...Full Text Available

Science.gov (United States)

The anesthetic agents methohexital (Brevital), Innovar, and ketamine (Ketaject) were examined for their effect on seizure duration following electroconvulsive stimulation in a rat model of electroconvulsive therapy (ECT). Compared to unanesthetized control animals, methohexital anesthesia shortened seizure duration by 42%, ketamine anesthesia tended to increase seizure duration, and Innovar anesthesia had no effect on duration of seizures. PMID:7349626

UK PubMed Central (United Kingdom)

The current investigation attempted to confirm the beneficial actions of a chemically characterized Radix Astragali decoction (AM-W) against type 2 diabetic (T2D) Sprague-Dawley (SD) rats. Using a case/control...Full Text Available